title: Prevention of thrombogenesis from whole human blood on plastic polymer by ultrathin monoethylene glycol silane adlayer.
abstract: In contemporary society, a large percentage of medical equipment coming in contact with blood is manufactured from plastic polymers. Unfortunately, exposure may result in undesirable protein-material interactions that can potentially trigger deleterious biological processes such as thrombosis. To address this problem, we have developed an ultrathin antithrombogenic coating based on monoethylene glycol silane surface chemistry. The strategy is exemplified with polycarbonate--a plastic polymer increasingly employed in the biomedical industry. The various straightforward steps of surface modification were characterized with X-ray photoelectron spectroscopy supplemented by contact angle goniometry. Antithrombogenicity was assessed after 5 min exposure to whole human blood dispensed at a shear rate of 1000 s(-1). Remarkably, platelet adhesion, aggregation, and thrombus formation on the coated surface was greatly inhibited (>97% decrease in surface coverage) compared to the bare substrate and, most importantly, nearly nonexistent.
authors.affiliation: Institute of Biomaterials & Biomedical Engineering, University of Toronto , Toronto, Ontario, Canada.
authors.forename: Kiril
authors.initials: K
authors.lastname: Fedorov
authors.forename: Christophe
authors.initials: C
authors.lastname: Blaszykowski
authors.forename: Sonia
authors.initials: S
authors.lastname: Sheikh
authors.forename: Adili
authors.initials: A
authors.lastname: Reheman
authors.forename: Alexander
authors.initials: A
authors.lastname: Romaschin
authors.forename: Heyu
authors.initials: H
authors.lastname: Ni
authors.forename: Michael
authors.initials: M
authors.lastname: Thompson
mesh_terms: D001559:Benzhydryl Compounds / Q000737:chemistry; D019855:Ethylene Glycol / Q000737:chemistry*; D006801:Humans; D010636:Phenols / Q000737:chemistry; D010969:Plastics / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D011076:Polycarboxylate Cement / Q000737:chemistry; D012821:Silanes / Q000737:chemistry*; D013499:Surface Properties; D013927:Thrombosis / Q000517:prevention & control*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D019855:Ethylene Glycol; D010636:Phenols; D010969:Plastics; D011076:Polycarboxylate Cement; D012821:Silanes; C005506:polycarbonate; C006780:bisphenol A; D000098826:Bisphenol A Compounds