title: Aging: it's SIRTainly possible to restore mitochondrial dysfunction.
abstract: Mitochondrial dysfunction is strongly associated with aging. A recent study shows that reduced nuclear SIRT1 activity initiates age-related mitochondrial decline through a signaling pathway that perturbs expression of genes encoded by mitochondrial DNA. This reversible pathway has potential anti-aging therapeutic value.
authors.affiliation: Departments of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
authors.forename: Brooke E
authors.initials: BE
authors.lastname: Christian
authors.affiliation: Departments of Pathology, Yale School of Medicine, New Haven, CT 06520, USA; Genetics, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: Gerald.Shadel@yale.edu.
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Shadel
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D010085:Oxidative Phosphorylation
chemical_list: D009243:NAD