title: All eotaxins CCL11, CCL24 and CCL26 are increased but to various extents in pulmonary tuberculosis patients.
abstract: BACKGROUND
  Mycobacterium tuberculosis is a pulmonary pathogen responsible for tuberculosis. Tuberculosis (TB) is characterized histologically by granulomas at the site of disease activity. Primary pathologic feature of TB is formation of a granuloma, and chemokines are known to play an important role in the formation of granulomas during infection. Therefore, the aim of this study was to evaluate the serum levels of CCL11, CCL24, and CCL26 in the TB patients in comparison to healthy controls.
  
  
  METHODS
  The population of this cross-sectional study included 300 patients suffering from TB and 100 healthy controls. Concentrations of CCL11, CCL24, and CCL26 were measured by enzyme linked immunosorbent assay (ELISA) technique. The results were analyzed using SPSS software package version 18. Differences were considered significant where p was less than 0.05.
  
  
  RESULTS
  The results showed significant elevated serum levels of CCL11, CCL24, and CCL26 in TB patients compared to controls.
  
  
  CONCLUSIONS
  According to the present results it can be concluded that CCL11, CCL24, and CCL26 (which are produced by Th2 cells and other cells which induce Th2 development) are increased in TB patients; hence, it seems that TB suppresses Th1 and the classic function of macrophages subsequently by inducing the chemokines' expression.
authors.affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Abumoslem Rashidi
authors.initials: AR
authors.lastname: Sharifabadi
authors.affiliation: Molecular-Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Hassanshahi
authors.affiliation: Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Seyed Razi
authors.initials: SR
authors.lastname: Ghalebi
authors.affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Mohammad Kazemi
authors.initials: MK
authors.lastname: Arababadi
authors.affiliation: Molecular-Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Khorramdelazad
authors.affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Zainodini
authors.affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Ziba
authors.initials: Z
authors.lastname: Shabani
mesh_terms: D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D054413:Chemokine CCL11 / Q000378:metabolism*; D054423:Chemokine CCL24 / Q000378:metabolism*; D000075906:Chemokine CCL26; D019742:Chemokines, CC / Q000378:metabolism*; D003430:Cross-Sectional Studies; D017931:DNA Primers; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D013183:Sputum / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000378:metabolism*; D055815:Young Adult
chemical_list: C515456:CCL11 protein, human; C515484:CCL24 protein, human; C120429:CCL26 protein, human; D054413:Chemokine CCL11; D054423:Chemokine CCL24; D000075906:Chemokine CCL26; D019742:Chemokines, CC; D017931:DNA Primers