title: How to win ATP and influence Ca(2+) signaling.
abstract: This brief review discusses recent advances in studies of mitochondrial Ca(2+) signaling and considers how the relationships between mitochondria and Ca(2+) responses are shaped in secretory epithelial cells. Perhaps the more precise title of this review could have been "How to win ATP and influence Ca(2+) signaling in secretory epithelium with emphasis on exocrine secretory cells and specific focus on pancreatic acinar cells". But "brevity is a virtue" and the authors hope that many of the mechanisms discussed are general and applicable to other tissues and cell types. Among these mechanisms are mitochondrial regulation of Ca(2+) entry and the role of mitochondria in the formation of localized Ca(2+) responses. The roles of Ca(2+) signaling in the physiological adjustment of bioenergetics and in mitochondrial damage are also briefly discussed.
authors.affiliation: Department of Cellular and Molecular Physiology, The Physiological Laboratory, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Voronina
authors.affiliation: Department of Cellular and Molecular Physiology, The Physiological Laboratory, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Okeke
authors.affiliation: Department of Cellular and Molecular Physiology, The Physiological Laboratory, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
authors.forename: Tony
authors.initials: T
authors.lastname: Parker
authors.affiliation: Department of Cellular and Molecular Physiology, The Physiological Laboratory, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK. Electronic address: a.tepikin@liv.ac.uk.
authors.forename: Alexei
authors.initials: A
authors.lastname: Tepikin
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D046790:Pancreas, Exocrine / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D053496:Inositol 1,4,5-Trisphosphate Receptors; D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate; D002118:Calcium
keywords: IP(3) receptors; Mitochondria; ROS; Secretory epithelium; Store-operated Ca(2+) entry