title: In vitro effect of danazol on endometrioma cells in culture.
abstract: OBJECTIVE
  To evaluate the effect of danazol on endometrioma cells in culture, in relation to cell proliferation.
  
  
  METHODS
  Danazol has been shown to be effective in treating endometriosis, leading to remission. The mode of action is through suppression of gonadotropins. A direct effect on endometriosis implants has been suggested. This study was conducted on endometrioma cell lines using various concentrations of danazol in ethanol solution.
  
  
  RESULTS
  Danazol showed a decrease in proliferation ofendometrioma cells in culture. This was also associated with an increase in apoptosis and necrosis ofcultured cells.
  
  
  CONCLUSIONS
  This study demonstrates the direct effect of danazol on endometrioma cells in culture.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Upstate Medical University, Syracuse, New York, USA.
authors.forename: Beth Ann
authors.initials: BA
authors.lastname: Ollivierre
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Upstate Medical University, Syracuse, New York, USA.
authors.forename: Violeta
authors.initials: V
authors.lastname: Cuenca
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Upstate Medical University, Syracuse, New York, USA.
authors.forename: Lydia
authors.initials: L
authors.lastname: Kaufman
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Upstate Medical University, Syracuse, New York, USA.
authors.forename: Shawky Z A
authors.initials: SZ
authors.lastname: Badawy
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D003613:Danazol / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004715:Endometriosis / Q000473:pathology*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D006801:Humans
chemical_list: D004965:Estrogen Antagonists; D003613:Danazol