title: Targeted singlet oxygen generation using different DNA-interacting perylene diimide type photosensitizers.
abstract: Singlet oxygen quantum yields (ΦΔ) of different perylene diimides (PDIs) containing phenyl (PDI-Ph), pyrene (PDI-Pyr), and indole (PDI-In) units in bay positions of the ring were determined using 1,3-diphenylisobenzofuran (DPBF) method in toluene/methanol (99:1) system. Pyrene-substituted PDI were the most efficient singlet oxygen generator among the investigated photosensitizers with a quantum yield of Φ Δ = 0.93 in toluene/methanol. Additionally, their binding affinities to G-quadruplex DNA structure were investigated by steady-state measurements. There were marked red shifts of absorbance bands for PDI-Pyr/DNA strand complexes with respect to the absorption maxima of DNA-free solution of PDI-Pyr in phosphate buffer at pH 6.
authors.affiliation: Department of Chemistry, Faculty of Arts and Science, Celal Bayar University, Muradiye, 45030, Manisa, Turkey, haluk.dincalp@cbu.edu.tr.
authors.forename: Haluk
authors.initials: H
authors.lastname: Dinçalp
authors.forename: Şevki
authors.initials: Ş
authors.lastname: Kızılok
authors.forename: Sıddık
authors.initials: S
authors.lastname: İçli
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D054856:G-Quadruplexes; D007094:Imides / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000378:metabolism; D011789:Quantum Theory; D026082:Singlet Oxygen / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007094:Imides; D017319:Photosensitizing Agents; C521332:perylenediimide; D026082:Singlet Oxygen; D010569:Perylene; D004247:DNA