title: Factors affecting the outcome of "endometrial scratch" in women with recurrent implantation failure.
abstract: OBJECTIVE
  To examine factors affecting the outcome of the endometrial scratch in women with recurrent implantation failure.
  
  
  METHODS
  A total of 57 eligible patients with a history of recurrent implantation failure underwent an endometrial biopsy in the luteal phase of the menstrual cycle in the month immediately preceding the embryo transfer cycle. The comparative group consisted of a retrospective cohort of 66 women with recurrent implantation failure but without endometrial biopsy. There were no significant differences between the intervention and control groups in terms of age, follicle-stimulating hormone (FSH), free androgen index, anti-Müllerian hormone, body mass index, the number of embryos transferred, and the number of embryo transfer cycles.
  
  
  RESULTS
  The clinical pregnancy rate in the intervention group (53%) was significantly (p < 0.001) higher than that of the control group (15%). The only predictive factor was FSH. Women with FSH < or =10 IU/L had a pregnancy rate of 57.8%, significantly (p < 0.05) higher than that (20%) of women with FSH >10 IU/L.
  
  
  CONCLUSIONS
  Women with a normal FSH are more likely to derive benefit from endometrial scratch.
authors.affiliation: Department of Reproductive Medicine, Jessop Wing Assisted Conception Unit, Sheffield, UK. carol.coughlan@hari.ie
authors.forename: Carol
authors.initials: C
authors.lastname: Coughlan
authors.affiliation: Department of Reproductive Medicine, Jessop Wing Assisted Conception Unit, Sheffield, UK.
authors.forename: Xi
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Department of Reproductive Medicine, Jessop Wing Assisted Conception Unit, Sheffield, UK.
authors.forename: Aygul
authors.initials: A
authors.lastname: Demirol
authors.affiliation: Department of Reproductive Medicine, Jessop Wing Assisted Conception Unit, Sheffield, UK.
authors.forename: William
authors.initials: W
authors.lastname: Ledger
authors.affiliation: Department of Reproductive Medicine, Jessop Wing Assisted Conception Unit, Sheffield, UK.
authors.forename: Tin Chiu
authors.initials: TC
authors.lastname: Li
mesh_terms: D000328:Adult; D001706:Biopsy; D015331:Cohort Studies; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000379:methods; D004717:Endometrium / Q000473:pathology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007246:Infertility / Q000628:therapy; D011247:Pregnancy; D018873:Pregnancy Rate; D012008:Recurrence; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D005640:Follicle Stimulating Hormone