title: Transmucosal delivery of Docetaxel by mucoadhesive polymeric nanofibers.
abstract: The aim of the present study is to design a mucoadhesive nano-carrier system which retains at the site of application and maximizes the therapeutic potential of anticancer drug as well as reduces their systemic side effects. In the present study PVA nanofibers of Docetaxel were prepared using electrospinning machine. The resulting nanofibers were characterized through various parameters such as surface morphology, drug loading, in-vitro drug release, tensile strength, mucoadhesiveness, drug permeability, degree of swelling and anticancer activities against selective cell lines to establish their therapeutics potential. On the basis of various evaluation results, we may conclude that the current approach comprising polymeric nanofibers can be successfully used for local delivery of anticancer drug.
authors.affiliation: Department of Pharmaceutics, ISF College of Pharmacy , Moga, Punjab , India.
authors.forename: Harmanpreet
authors.initials: H
authors.lastname: Singh
authors.forename: Rahul
authors.initials: R
authors.lastname: Sharma
authors.forename: Munish
authors.initials: M
authors.lastname: Joshi
authors.forename: Tarun
authors.initials: T
authors.lastname: Garg
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Goyal
authors.forename: Goutam
authors.initials: G
authors.lastname: Rath
mesh_terms: D000818:Animals; D000077143:Docetaxel; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006041:Goats; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D057139:Nanofibers / Q000737:chemistry*; D043823:Taxoids / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D043823:Taxoids; D000077143:Docetaxel
keywords: cytotoxicity; degree of swelling; electrospinning; mucoadhesive patch; nanofibers