title: Cellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways.
abstract: The interconnectivity between diet, gut microbiota and cell molecular responses is well known; however, only recently has technology allowed the identification of strains of microorganisms harbored in the gastrointestinal tract that may increase susceptibility to cancer. The colonic environment appears to play a role in the development of colon cancer, which is influenced by the human metabolic lifestyle and changes in the gut microbiome. Studying metabolic changes at the cellular level in cancer be useful for developing novel improved preventative measures, such as screening through metabolic breath-tests or treatment options that directly affect the metabolic pathways responsible for the carcinogenicity.
authors.affiliation: Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway; Gastrointestinal Translational Research Unit, Molecular Lab, Stavanger University Hospital, Stavanger, Norway.
authors.forename: Hanne R
authors.initials: HR
authors.lastname: Hagland
authors.affiliation: Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway; Gastrointestinal Translational Research Unit, Molecular Lab, Stavanger University Hospital, Stavanger, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway. Electronic address: ksoreide@mac.com.
authors.forename: Kjetil
authors.initials: K
authors.lastname: Søreide
mesh_terms: D015992:Body Mass Index; D063646:Carcinogenesis / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D004032:Diet; D041981:Gastrointestinal Tract / Q000382:microbiology* / Q000473:pathology; D006019:Glycolysis / Q000502:physiology; D006801:Humans; D008019:Life Style; D053858:Metabolic Networks and Pathways; D064307:Microbiota; D009765:Obesity / Q000150:complications; D010085:Oxidative Phosphorylation; D012307:Risk Factors
keywords: Butyrate; Colorectal cancer; Diet; Energy metabolism; Microbiota; Mitochondria