title: Activation of PP2A by perphenazine induces apoptosis in T-ALL.
abstract: Drug repurposing screens identify the antipsychotic agent perphenazine as active against T-ALL.
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D010546:Perphenazine / Q000494:pharmacology*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D054648:Protein Phosphatase 2 / Q000378:metabolism*; D051881:Receptor, Notch1 / Q000037:antagonists & inhibitors
chemical_list: D000970:Antineoplastic Agents; C497761:NOTCH1 protein, human; D051881:Receptor, Notch1; D054648:Protein Phosphatase 2; D010546:Perphenazine