title: Arterial hypertension during treatment with triptorelin in a child with Williams-Beuren syndrome.
abstract: BACKGROUND
  Arterial hypertension (AHT) is a common finding in children with Williams-Beuren syndrome (WBS). Although cardiovascular and renal abnormalities can explain the AHT in some patients with WBS, its etiology is not fully understood and most cases are considered idiopathic.
  
  
  METHODS
  The case is reported of a 10-year-old girl with WBS who developed severe AHT during treatment with triptorelin, a long-lasting gonadotropin-releasing hormone (GnRH) analog, administered because of early normal puberty. Comprehensive diagnostic studies ruled out other known causes of AHT associated with WBS. After discontinuation of triptorelin, the blood pressure remained within the normal range for her age and height with no antihypertensive treatment on long-term follow-up. To the best of the authors' knowledge, this is the first report of AHT associated with triptorelin administration in a child with WBS.
  
  
  CONCLUSIONS
  Clinicians should be aware of the possibility, although rare, of AHT developing during triptorelin administration in childhood, specifically in patients at increased risk of AHT, such as those with WBS.
authors.affiliation: Departments of Pediatrics, University Hospital of Ioannina, Stavros Niarchos Avenue, 45 500, Ioannina, Greece, eksiomou@yahoo.gr.
authors.forename: Ekaterini
authors.initials: E
authors.lastname: Siomou
authors.forename: Chrysoula
authors.initials: C
authors.lastname: Kosmeri
authors.forename: Maria
authors.initials: M
authors.lastname: Pavlou
authors.forename: Antonios P
authors.initials: AP
authors.lastname: Vlahos
authors.forename: Maria I
authors.initials: MI
authors.lastname: Argyropoulou
authors.forename: Antigoni
authors.initials: A
authors.lastname: Siamopoulou
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D008186:Luteolytic Agents / Q000009:adverse effects*; D011629:Puberty, Precocious / Q000188:drug therapy / Q000209:etiology; D017329:Triptorelin Pamoate / Q000009:adverse effects*; D018980:Williams Syndrome / Q000150:complications / Q000188:drug therapy*
chemical_list: D008186:Luteolytic Agents; D017329:Triptorelin Pamoate