title: Clinical course of patients with aspirin-exacerbated respiratory disease: can we predict the prognosis?
abstract: OBJECTIVE
  This study aimed to identify prognostic factors of aspirin-exacerbated respiratory disease by comparing clinical and genetic data with the clinical course.
  
  
  METHODS
  Patients were classified into two groups according to their response to inhalation rechallenge with lysine-aspirin after at least 1 year of regular treatment with antiasthmatic medications.
  
  
  RESULTS
  Forty eight patients (39.3%, group I) had negative responses, whereas 74 patients (60.7%, group II) had positive responses (n = 23) or were not rechallenged owing to persistent symptoms (n = 51). FEV₁ at diagnosis and follow-up were significantly lower in group II than in group I. The CCR3 polymorphism at -520T/G differed significantly between the two groups, whereas no difference was found in other SNPs.
  
  
  CONCLUSIONS
  Baseline FEV₁ and lower lung function after treatment were clinical factors indicating a poor prognosis of aspirin-exacerbated respiratory disease. The G allele of CCR3 -520T>G was associated with persistent bronchial hypersensitivity to aspirin.
authors.affiliation: Division of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 896 Pyeongan-dong, Dongan-gu, Anyang, Gyeonggi, 431-796, Republic of Korea.
authors.forename: Joo-Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Gil-Soon
authors.initials: GS
authors.lastname: Choi
authors.forename: Jeong-Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Jin
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Ye
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Hae-Sim
authors.initials: HS
authors.lastname: Park
mesh_terms: D000328:Adult; D000483:Alleles; D001241:Aspirin / Q000009:adverse effects*; D055963:Asthma, Aspirin-Induced / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis
chemical_list: D001241:Aspirin