title: Factors influencing malignant evolution and long-term survival in solitary fibrous tumours of the pleura.
abstract: Solitary pleuro-pulmonary fibrous tumours are relatively uncommon neoplasms that are difficult to manage therapeutically and which, cytogenetically, have been poorly studied. The aim of the present work was to analyse the characteristics of a series of consecutive operated solitary pleural fibrous tumours in an attempt to discover a malignant pattern of evolution. This was a retrospective observational study of 19 cases. Samples were studied for clinical, histological, immunohistochemical and cytogenetic characteristics (aCGH, FISH). Descriptive statistics were used: the Kapplan-Meyer log-rank test and the Cox-regression model for survival analysis. Analysis of malignant evolution was achieved using 2x2 tables; significant factors were included in a binary logistic regression model. Parietal pleural implantation of the primary tumour, high mib1 expression, and low p53 expression were seen to be statistically significant factors for survival. We recommend a close follow-up for patients with a malignant primary tumour and low p53 expression and a regular long-term follow-up for benign primary tumours with a high mib1 index, high positive p53, and deletions. These findings need confirmation in more extensive series.
authors.affiliation: Pathology Department. University Hospital of Salamanca, Salamanca, Spain. marta_rg@usal.es.
authors.forename: Marta
authors.initials: M
authors.lastname: Rodriguez-Gonzalez
authors.affiliation: Thoracic Surgery Department. - Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
authors.forename: Nuria M
authors.initials: NM
authors.lastname: Novoa
authors.affiliation: Thoracic Surgery Department. University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Maria T
authors.initials: MT
authors.lastname: Gomez
authors.affiliation: Research Unit of the University Hospital of Salamanca, Spain - Centre for Cancer Research, Salamanca (CIC IBMCC-CSIC/USAL), Salamanca, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Garcia
authors.affiliation: Pathology Department. University Hospital of Salamanca, Spain - Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Ludeña
mesh_terms: D000328:Adult; D000368:Aged; D055028:Comparative Genomic Hybridization; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D010994:Pleura / Q000473:pathology*; D010997:Pleural Neoplasms / Q000401:mortality* / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012189:Retrospective Studies; D054364:Solitary Fibrous Tumors / Q000401:mortality* / Q000473:pathology*