title: [Clinical pathological analysis of 7 cases of primary tonsil diffuse large B cell lymphoma].
abstract: Tonsil is the most frequent site of the head and neck non-Hodgkin's lymphoma (NHL), and the diffuse large B cell lymphoma (DLBCL) is the most common pathological type in tonsil NHL. The aim of this study was to investigate the characteristics of clinical manifestation, immunophenotype, prognostic factor of primary tonsil DLBCL and its treatment strategy. The clinical data of 7 newly diagnosed patients with primary tonsil DLBCL from October 2009 to February 2013 were analyzed retrospectively. The results indicated that the pharynx or sore throat as the fist symptom was found in all patients. Out of 7 cases, 3 was in Ann Arbor stage I (42.8%), a case was in stage II (57.1%). Pathological immunohistochemical detection showed that the CD10 positive rate was 100%, BCL-2 positive rate was 83.3%, BCL-6 positive rate was 71.4%, Ki-67 ≥ 70% was 66.7%. They were all sensitive to chemotherapy and radiotherapy. Following up 4 to 40 months, they were all alive. It is concluded that most patients with primary tonsil DLBCL are at early stage, have an obvious characteristics of onset ages, clinical manifestations, pathological histology and achieve better remission through combined chemotherapy and radiotherapy.
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Han
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Li
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China. E-mail: xuwei10000@medmail.com.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012189:Retrospective Studies; D014067:Tonsillar Neoplasms