title: Recent insights into hepatitis B virus-host interactions.
abstract: Hepatitis B virus (HBV) poses a threat to global public health mainly because of complications of HBV-related chronic liver disease. HBV exhibits a narrow host range, replicating primarily in hepatocytes by a still poorly understood mechanism. For the generation of progeny virions, HBV depends on interactions with specific host factors through its life cycle. Revealing and characterizing these interactions are keys to identifying novel antiviral targets, and to developing specific treatment strategies for HBV patients. In this review, recent insights into the HBV-host interactions, especially on virus entry, intracellular trafficking, genome transcription and replication, budding and release, and even cellular restriction factors were reviewed.
authors.affiliation: Virology Unit, Viral Hepatitis Laboratory, Pasteur Institute of Morocco, Casablanca, Morocco; Transboundary Animal Diseases Centre, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
authors.forename: Sayeh
authors.initials: S
authors.lastname: Ezzikouri
authors.forename: Makoto
authors.initials: M
authors.lastname: Ozawa
authors.forename: Michinori
authors.initials: M
authors.lastname: Kohara
authors.forename: Naima
authors.initials: N
authors.lastname: Elmdaghri
authors.forename: Soumaya
authors.initials: S
authors.lastname: Benjelloun
authors.forename: Kyoko
authors.initials: K
authors.lastname: Tsukiyama-Kohara
mesh_terms: D006515:Hepatitis B virus / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D053586:Virus Internalization; D057074:Virus Release; D014779:Virus Replication
keywords: HBV; cccDNA; host factors; new target; receptors; replication