title: [Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue].
abstract: OBJECTIVE
  To study the effects of rosuvastatin on insulin resistance in overweight rats induced by high fat diet, as well as potential mediators.
  
  
  METHODS
  We used male Wistar rats fed with a standard diet (CT) or high fat diet (33.5% fat) (HFD); half of the animals HFD were treated with rosuvastatin (15mg/kg/day) (HFD+Rosu) for 7 weeks.
  
  
  RESULTS
  HFD rats showed increased body, epididymal and lumbar adipose tissue weights. Treatment with Rosu did not modify body weight or the weight of the adipose packages in HFD rat. Plasma glucose and insulin levels and HOMA index were higher in HFD rats, and rosuvastatin treatment reduced them. Leptin/adiponectin ratio in plasma and lumbar adipose tissue were higher in HDF rats, and were reduced by rosuvastatin. SIRT-1, PPAR-γ and GLUT-4 protein expression in lumbar adipose tissue were lower in HFD rats and Rosu normalized expression of the three mediators.
  
  
  CONCLUSIONS
  Rosuvastatin ameliorates insulin sensitivity induced by HFD in rats. This effect is mediated by several mechanisms including reduction of leptin and enhancement of SIRT-1, PPAR-γ and GLUT-4 expression in white adipose tissue. SIRT1 could be considered a major mediator of the beneficial effects of rosuvastatin on insulin sensitivity in overweight rats induced by diet.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, Madrid, España.
authors.forename: María
authors.initials: M
authors.lastname: Valero-Muñoz
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, Madrid, España.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Martín-Fernández
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, Madrid, España.
authors.forename: Sandra
authors.initials: S
authors.lastname: Ballesteros
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, Madrid, España.
authors.forename: Victoria
authors.initials: V
authors.lastname: Cachofeiro
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, Madrid, España.
authors.forename: Vicente
authors.initials: V
authors.lastname: Lahera
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, Madrid, España. Electronic address: nataliaheras@med.ucm.es.
authors.forename: Natalia
authors.initials: N
authors.lastname: de Las Heras
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D059305:Diet, High-Fat; D005464:Fluorobenzenes / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D051275:Glucose Transporter Type 4 / Q000235:genetics; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D050177:Overweight / Q000188:drug therapy* / Q000503:physiopathology; D047495:PPAR gamma / Q000235:genetics; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000068718:Rosuvastatin Calcium; D056564:Sirtuin 1 / Q000235:genetics*; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D005464:Fluorobenzenes; D051275:Glucose Transporter Type 4; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007328:Insulin; D047495:PPAR gamma; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium; C488368:Sirt1 protein, rat; D056564:Sirtuin 1
keywords: Adipose tissue; Estatinas; Insulin resistance; Overweight; Resistencia a la insulina; Sirtuin 1; Sirtuina 1; Sobrepeso; Statin; Tejido adiposo