title: Practical metal-free C(sp(3))-H functionalization: construction of structurally diverse α-substituted N-benzyl and N-allyl carbamates.
abstract: Described is a practical and universal CH functionalization of readily removable N-benzyl and N-allyl carbamates, with a wide range of nucleophiles at ambient temperature promoted by Ph3 CClO4 . The metal-free reaction has an excellent functional-group tolerance, and displays a broad scope with respect to both N-carbamates and nucleophile partners (a variety of organoboranes and CH compounds). The synthetic utility in target- as well as diversity-oriented syntheses is demonstrated.
authors.affiliation: Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012 (China) http://www.pharm.sdu.edu.cn/szdw/Liu%20lei/3/Liu_02/index.htm.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Xie
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Wenfang
authors.initials: W
authors.lastname: Chen
authors.forename: Hongbo
authors.initials: H
authors.lastname: Zheng
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Xu
authors.forename: Huiqing
authors.initials: H
authors.lastname: Yuan
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Lou
mesh_terms: D002219:Carbamates / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure
chemical_list: D002219:Carbamates; C034650:allyl carbamate
keywords: CH functionalization; antitumor agents; nitrogen heterocycles; organoboranes; synthetic methods