title: The effect of IGF-1 on symptoms of sleep deprivation in a rat model of inflammatory heart disease and metabolic syndrome.
abstract: Sleep deprivation (SD) has become a worldwide public health concern due to the many negative health consequences associated with suboptimal sleep. SD has been linked to a catabolic hormone signature, heart disease, hypertension, diabetes, and an increase in morbidity and mortality. Herein, we investigated the effects and mechanism of SD on cardiac and metabolic health and evaluated the impact of exogenously supplied IGF-1 on these symptoms. In the present study, we show that 5 days of acute SD negatively impacted all of the various indicators of cardiac and metabolic health. All symptoms of SD were ameliorated by daily administration of IGF-1, however. IGF-1 administration also reduced the phosphorylation of Akt and expression of Bax, a promoter of apoptosis. Conversely, the expression of Bcl-2, an inhibitor of apoptosis, was elevated by IGF-1, and all IGF-1 effects were suppressed by the PI3K/Akt inhibitor LY294002, reaffirming the importance of the PI3K/Akt pathway in the maintenance of cardiac and metabolic health.
authors.affiliation: Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Zhengqing
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Jiaoyang
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Xiangfang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Zou
authors.affiliation: Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. Electronic address: young.stone@163.com.
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. Electronic address: zmliu_cz@hotmail.com.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D002867:Chromones / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006331:Heart Diseases / Q000209:etiology* / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage / Q000627:therapeutic use*; D053583:Interleukin-1beta / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000378:metabolism; D009025:Morpholines / Q000494:pharmacology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010766:Phosphorylation / Q000187:drug effects; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation / Q000150:complications* / Q000188:drug therapy*; D051028:bcl-2-Associated X Protein / Q000032:analysis
chemical_list: D002867:Chromones; D004791:Enzyme Inhibitors; D007334:Insulin-Like Growth Factor I; D053583:Interleukin-1beta; D015850:Interleukin-6; D009025:Morpholines; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
keywords: Heart disease; IGF-1; PI3K/Akt; Sleep deprivation