title: Effect of Morinda citrifolia fruit extract and its iridoid glycosides on blood fluidity.
abstract: The aim of this study was to investigate the effect of Morinda citrifolia fruit on blood fluidity. M. citrifolia fruit extract (MCF-ext) was investigated for its influence on blood aggregation and fibrinolysis. MCF-ext inhibited polybrene-induced erythrocyte aggregation and thrombin activity. The fibrinolytic activity of MCF-ext, in the euglobulin lysis time test and fibrin plate assay, is reported here for the first time. One of the active compounds was an iridoid glycoside, asperulosidic acid. The results indicated that MCF-ext is a potentially useful health food which is capable of improving blood flow and preventing lifestyle-related diseases.
authors.affiliation: Faculty of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashiosaka, Osaka, 577-8502, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Murata
authors.forename: Yumi
authors.initials: Y
authors.lastname: Abe
authors.forename: Megumi
authors.initials: M
authors.lastname: Futamura-Masuda
authors.forename: Akemi
authors.initials: A
authors.lastname: Uwaya
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Isami
authors.forename: Shixin
authors.initials: S
authors.lastname: Deng
authors.forename: Hideaki
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D005342:Fibrinolysis; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D057889:Iridoid Glycosides / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D032066:Morinda / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006027:Glycosides; D057889:Iridoid Glycosides; D010936:Plant Extracts; C432744:asperulosidic acid