title: Meta-analysis of associations between four polymorphisms in the matrix metalloproteinases gene and gastric cancer risk.
abstract: BACKGROUND
  Matrix metalloproteinases (MMPs) play important roles in pathogenesis and development of cancer. Recently, many studies have show associations between polymorphisms in the promoter regions of MMPs and risk of gastric cancer. The present meta-analysis was conducted in order to investigate the potential association between four polymorphisms in the MMP gene and gastric cancer risk.
  
  
  METHODS
  A computerized literature search was conducted in databases of Med-line, Embase, Science Citation Index and PubMed till June 2013 for any MMP genetic association study of gastric cancer. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated for each gene under dominant and recessive models, and heterogeneity between studies was assessed using the Q test and I2 value. Overall and subgroup analyses according to ethnicity were carried out with Stata 12.0.
  
  
  RESULTS
  14 reports covering 8,146 patients (2,980 in the case group and 5,166 in the control group) were included in the present meta-analysis. We found that the MMP-7 (-181A>G) polymorphism increased the gastric cancer risk in therecessive model (GG vs. AA/AG, OR=1.768, 95% CI =1.153-2.712). For MMP2 ?1306 C>T, MMP1-1607 1G/2G, and MMP9?1 562 C>T, there were no associations between these polymorphisms and the risk of gastric cancer under dominant or recessive models.
  
  
  CONCLUSIONS
  This meta-analysis suggested that the MMP7-181 A>G polymorphism may contribute to gastric cancer susceptibility. More studies are needed, especially in Europeans, in the future.
authors.affiliation: Department of Gastroenterology Surgery, Affiliated Shengjing Hospital of China Medical University, Shenyang, China E-mail : cmuwangq@163.com.
authors.forename: Teng-Fei
authors.initials: TF
authors.lastname: Yang
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
mesh_terms: D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics; D020778:Matrix Metalloproteinase 2 / Q000235:genetics; D020783:Matrix Metalloproteinase 7 / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D020782:Matrix Metalloproteinases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012306:Risk; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D020782:Matrix Metalloproteinases; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1