title: Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes.
abstract: METHODS
  Inflammatory status can increase the risk of adverse cardiovascular events linked to platelet activity and involvement of microparticles (MP) released from platelets (PMP), leukocytes (LMP), and monocytes (MMP). These MP carry host cell-derived antigens that may act as markers of metabolic health. Subjects newly diagnosed with type 2 diabetes are offered appropriate standard dietary advice (SDA) but this may not be optimal as specific inclusion of other nutrients, such as oats, may add benefit. The effectiveness of such interventions can be tested by examination of MP activation markers.
  
  
  RESULTS
  Subjects (n = 22) with type 2 diabetes participated in a randomized cross-over trial involving 8 wk interventions with either an oat-enriched diet (OAT) or following reinforced SDA. Responses were also compared with preintervention habitual (HAB) intake. OAT reduced the concentrations and proportions of fibrinogen- and tissue factor-related PMP and MMP_11b. The main effect of SDA was to reduce fibrinogen-activated PMP. Regardless of chronic intake, a healthy test meal led to postprandial declines in total PMP as well as tissue factor-, fibrinogen-, and P-selectin-positive PMP.
  
  
  CONCLUSIONS
  OAT improved risk factors assessed by MP status, even in subjects with type 2 diabetes already well-controlled by diet and life-style alone.
authors.affiliation: Obesity and Metabolic Health Division, Rowett Institute of Nutrition & Health, University of Aberdeen, Aberdeen, UK; Provexis PLC, Rowett Institute of Nutrition & Health, Aberdeen, UK.
authors.forename: Xuguang
authors.initials: X
authors.lastname: Zhang
authors.forename: Susan C
authors.initials: SC
authors.lastname: McGeoch
authors.forename: Ian L
authors.initials: IL
authors.lastname: Megson
authors.forename: Sandra M
authors.initials: SM
authors.lastname: MacRury
authors.forename: Alexandra M
authors.initials: AM
authors.lastname: Johnstone
authors.forename: Prakash
authors.initials: P
authors.lastname: Abraham
authors.forename: Donald W M
authors.initials: DW
authors.lastname: Pearson
authors.forename: Baukje
authors.initials: B
authors.lastname: de Roos
authors.forename: Grietje
authors.initials: G
authors.lastname: Holtrop
authors.forename: Niamh
authors.initials: N
authors.lastname: O'Kennedy
authors.forename: Gerald E
authors.initials: GE
authors.lastname: Lobley
mesh_terms: D000328:Adult; D000368:Aged; D018554:Avena; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004032:Diet; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000378:metabolism; D019518:Postprandial Period / Q000502:physiology
chemical_list: D015415:Biomarkers; D019007:P-Selectin; D005340:Fibrinogen
keywords: Microparticles; Oats; Platelets; Standard dietary advice; Type 2 diabetes