title: Emergence of canine distemper virus strains with two amino acid substitutions in the haemagglutinin protein, detected from vaccinated carnivores in North-Eastern China in 2012-2013.
abstract: A total of 16 strains of canine distemper virus (CDV) were detected from vaccinated minks, foxes, and raccoon dogs in four provinces in North-Eastern China between the end of 2011 and 2013. Upon sequence analysis of the haemagglutinin gene and comparison with wild-type CDV from different species in the same geographical areas, two non-synonymous single nucleotide polymorphisms were identified in 10 CDV strains, which led to amino acid changes at positions 542 (isoleucine to asparagine) and 549 (tyrosine to histidine) of the haemagglutinin protein coding sequence. The change at residue 542 generated a potentially novel N-glycosylation site. Masking of antigenic epitopes by sugar moieties might represent a mechanism for evasion of virus neutralising antibodies and reduced protection by vaccination.
authors.affiliation: Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China; State Key Laboratory for Molecular Biology, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
authors.forename: Hailing
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Bai
authors.affiliation: Department of Veterinary Medicine, University of Bari Aldo Moro, Valenzano, 70010 Bari, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.affiliation: Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Hu
authors.affiliation: Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
authors.forename: Yangang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.affiliation: Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Xu
authors.affiliation: Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
authors.forename: Xiqun
authors.initials: X
authors.lastname: Shao
authors.affiliation: Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China; State Key Laboratory for Molecular Biology, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China. Electronic address: yanxijun@caas.cn.
authors.forename: Xijun
authors.initials: X
authors.lastname: Yan
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000822:Animal Husbandry; D000818:Animals; D002681:China; D004216:Distemper / Q000821:virology*; D004217:Distemper Virus, Canine / Q000235:genetics* / Q000302:isolation & purification; D005589:Foxes; D006389:Hemagglutinins, Viral / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D008907:Mink; D008969:Molecular Sequence Data; D010802:Phylogeny; D046031:Raccoon Dogs; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D016415:Sequence Alignment / Q000662:veterinary; D014611:Vaccination / Q000662:veterinary
chemical_list: D006389:Hemagglutinins, Viral
keywords: Canine distemper virus; Carnivores; Haemagglutinin; N-glycosylation