title: Genetic background influences nicotine-induced conditioned place preference and place aversion in mice.
abstract: This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of nicotine produced a significant place preference, whereas a high dose of nicotine produced place aversion in C3H mice. These effects were completely reversed by the nicotinic receptor antagonist mecamylamine. These results strongly suggest that a conditioned state, such as rewarding effects or aversive effects, can be influenced by genetic background.
authors.affiliation: Section of Pharmaceutical Services, Nippon Medical School Hospital.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Ise
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Mori
authors.forename: Shirou
authors.initials: S
authors.lastname: Katayama
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Suzuki
authors.forename: Tzu-Chueh
authors.initials: TC
authors.lastname: Wang
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains / Q000235:genetics*; D009538:Nicotine / Q000494:pharmacology*; D014029:Tobacco Use Disorder / Q000235:genetics
chemical_list: D009538:Nicotine