title: Serum endostatin concentrations are higher in men with symptoms of intermittent claudication.
abstract: OBJECTIVE
  A cleavage fragment of collagen XVIII, endostatin, is released into the circulation and has been demonstrated to have antiangiogenic effects in animal models. We hypothesized that circulating endostatin would be increased in patients with symptoms of lower limb peripheral artery disease.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Community dwelling older men.
  
  
  METHODS
  Intermittent claudication was defined using the Edinburgh Claudication Questionnaire (ECQ). Serum endostatin was measured by a commercial ELISA. The association of serum endostatin with intermittent claudication was examined using logistic regression adjusting for age, diabetes, hypertension, dyslipidemia, coronary heart disease, and stroke.
  
  
  RESULTS
  Serum endostatin was measured in 1114 men who completed the ECQ. 106 men had intermittent claudication, 291 had atypical pain, and 717 had no lower limb pain. Mean (± standard deviation) serum endostatin concentrations (ng/mL) were 145.22 ± 106.93 for men with intermittent claudication, 129.11 ± 79.80 for men with atypical pain, and 116.34 ± 66.57 for men with no lower limb pain; P < 0.001. A 70 ng/mL increase in endostatin was associated with a 1.17-fold rise in the adjusted odds of having intermittent claudication (OR 1.17, 95% confidence interval 1.00-1.37, and P = 0.050).
  
  
  CONCLUSIONS
  Serum endostatin is raised in older men who have symptoms of intermittent claudication. The role of endostatin in the genesis and outcome of peripheral artery disease requires further investigation.
authors.affiliation: The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia ; Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, QLD 4814, Australia.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Golledge
authors.affiliation: The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia.
authors.forename: Paula
authors.identifier: 0000-0002-0875-4873
authors.initials: P
authors.lastname: Clancy
authors.affiliation: School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6907, Australia ; Department of Neurology, Royal Perth Hospital, Perth, WA 6000, Australia.
authors.forename: Graeme J
authors.initials: GJ
authors.lastname: Hankey
authors.affiliation: School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6907, Australia ; Department of Endocrinology, Fremantle Hospital, Fremantle, WA 6160, Australia.
authors.forename: Bu B
authors.initials: BB
authors.lastname: Yeap
authors.affiliation: School of Surgery, University of Western Australia, Perth, WA 6907, Australia.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Norman
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D043169:Endostatins / Q000097:blood*; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood* / Q000175:diagnosis; D008297:Male; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D043169:Endostatins