title: A direct copper-promoted three-component entry to trifluoromethylketoximes.
abstract: A new copper-promoted three-component method for constructing ketoximes has been developed. This transformation can be achieved using indoles/pyrroles with the in situ generated 2,2,2-trifluorodiazoethane and nitrite species under mild conditions, thus offering a direct pathway to (E)-3-indolyl/2-pyrrolyl trifluoromethylketoximes.
authors.affiliation: Department of Chemistry, Key Laboratory of Systems Bioengineering (the Ministry of Education), Tianjin University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300072, P. R. of China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Jun-An
authors.initials: JA
authors.lastname: Ma
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006845:Hydrocarbons, Fluorinated; D007211:Indoles; D010091:Oximes; D003300:Copper