title: Misinterpretation of sural nerve conduction studies due to anatomical variation.
abstract: OBJECTIVE
  Anatomical variation of the sural nerve has been documented in numerous cadaver studies. The sural nerve conduction parameters can potentially be influenced by the sural nerve type A formation formed by the union of the medial sural cutaneous nerve (MSCN) and the peroneal communicating branch (PCB) and the type C formation with the sural nerve formed solely by the PCB.
  
  
  METHODS
  In 17 out of 240 prospectively examined subjects referred for polyneuropathy a suspicion of an anatomical variation of the sural nerve was raised due to decreased amplitude or substantial side-to-side variation (>50%) of the sensory nerve action potential (SNAP) in disproportion to the clinical findings. To verify the variation the sural nerve was examined further with surface electrodes and near-nerve technique, including extra lateral and distal needle placements.
  
  
  RESULTS
  In all 17 subjects an anatomical variation affecting the sural SNAP was confirmed as a normal sural SNAP could be obtained by changing the electrode placement. The most frequent variation, seen in 15 subjects, was a type A formation with union of the MSCN and the PCB distally at low calf, while a type C formation was seen in 2 subjects.
  
  
  CONCLUSIONS
  In case of a decreased sural SNAP amplitude or substantial side-to-side variation in disproportion to the neurologic evaluation, an anatomical variation instead of pathology could be suspected and a different electrode placement be considered.
  
  
  CONCLUSIONS
  Neurophysiologists should be aware of different types of formations of the sural nerve which may cause misinterpretations of nerve conduction studies, especially when needle electrodes are used.
authors.affiliation: Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: hatitank@rm.dk.
authors.forename: Hatice
authors.initials: H
authors.lastname: Tankisi
authors.affiliation: Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Pugdahl
authors.affiliation: Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Marit
authors.initials: M
authors.lastname: Otto
authors.affiliation: Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Fuglsang-Frederiksen
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D003951:Diagnostic Errors; D004568:Electrodiagnosis / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D011115:Polyneuropathies / Q000175:diagnosis*; D013497:Sural Nerve / Q000033:anatomy & histology* / Q000502:physiology*
keywords: Anatomical variation; Nerve conduction studies; Polyneuropathy; Sensory nerve action potential; Sural nerve