title: Molecular imaging biomarkers for oncology clinical trials.
abstract: Biomarkers can be used to characterize disease status or predict disease behavior. Cancer biomarkers have typically relied on assays of blood or tissue; however, molecular imaging has a promising and complementary role as a cancer biomarker. This "Focus on Molecular Imaging" article reviews the current role of biomarkers to direct cancer clinical trials and clinical practice, along with current and future cancer biomarker applications of molecular imaging.
authors.affiliation: Radiology/Nuclear Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and.
authors.forename: David A
authors.initials: DA
authors.lastname: Mankoff
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Pryma
authors.forename: Amy S
authors.initials: AS
authors.lastname: Clark
mesh_terms: D000818:Animals; D015415:Biomarkers; D014408:Biomarkers, Tumor; D002986:Clinical Trials as Topic; D023381:Endpoint Determination; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D011379:Prognosis; D011877:Radionuclide Imaging
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor
keywords: cancer biomarkers; cancer therapy; clinical trials