title: 3T magnetic resonance diffusion tensor imaging in chronic kidney disease.
abstract: OBJECTIVE
  To investigate the relationship of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values with renal function on 3T diffusion tensor imaging (DTI) in chronic kidney disease.
  
  
  METHODS
  Twenty healthy volunteers and 29 patients with CKD underwent DTI. The relationship among ADC, FA, and renal function was analyzed.
  
  
  RESULTS
  Cortical and medullary ADC and FA values of patients with chronic kidney disease were lower than those of healthy volunteers (P = 0.000). Both the renal ADC and FA values correlated inversely with serum creatinine and blood urea nitrogen (P < 0.05).
  
  
  CONCLUSIONS
  DTI is a feasible and non-invasive means to reflect the severity of renal function damaged.
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan 2th Road, Guangzhou, 510080, Guangdong, China.
authors.forename: Wen-juan
authors.initials: WJ
authors.lastname: Wang
authors.forename: Margaret H
authors.initials: MH
authors.lastname: Pui
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Li-qin
authors.initials: LQ
authors.lastname: Wang
authors.forename: Huan-jun
authors.initials: HJ
authors.lastname: Wang
authors.forename: Mingjuan
authors.initials: M
authors.lastname: Liu
mesh_terms: D000328:Adult; D016880:Anisotropy; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis*; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D055815:Young Adult