title: [Clinicopathological analysis of 64 case of angioimmunoblastic T-cell lymphoma].
abstract: OBJECTIVE
  To explore the clinical and pathological characteristics of angioimmunoblastic T-cell lymphoma (AITL).
  
  
  METHODS
  Sixty-four cases of AITL were retrospectively analyzed by histopathological and immunohistochemical methods.
  
  
  RESULTS
  There were 35 men and 29 women, the median age was 59 years (range, 25-84 ys). AITL typically presented with advanced stage, generalized lymphadenopathy, hepatosplenomegaly and systemic symptoms. Morphologically, the lymph nodes showed partial or total obliteration of the normal architecture by a polymorphic infiltration of lymphocytes, and by proliferation of follicular dendritic cells and that of high endothelial venules. Most cases contained a monoclonal T-cell population as well as clonal cytogenetic abnormalities. Immunophenotype analysis showed that neoplastic cells expressed the following markers: CXCL13 (positive rate 95.3%), PD-1 (positive rate 75.0%), CD10 (positive rate 25.0%), Bcl- 6 (positive rate 40.0%), CD2 (positive rate 96.0%), CD3 (positive rate 95.0%), CD4 (positive rate 84.0%), CD5 (positive rate 73.0%), EBER (positive rate 39.5%) and Ki-67 (average positive rate 55.0%), and frequently showed aberrant loss or reduced expression of CD7 and CD8.
  
  
  CONCLUSIONS
  The neoplastic cells of AITL showed features of CD4+ TFH, with peculiar clinical features. Peripheral T-cell lymphomas with a follicular growth pattern may show overlapping features with focal AITL.
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 100191, China.
authors.forename: Congyou
authors.initials: C
authors.lastname: Gu
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 100191, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 100191, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 100191, China.
authors.forename: Xuemin
authors.initials: X
authors.lastname: Xue
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 100191, China.
authors.forename: Zifen
authors.initials: Z
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000175:diagnosis / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies