title: Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis.
abstract: Background. Terminalia arjuna is a popular Indian medicinal plant with its bark been used for over centuries as cardiotonic. The bark has been found to contain several bioactive compounds including saponins and flavonoids. A number of experimental and clinical studies have been conducted to explore therapeutic potential of Terminalia arjuna in cardiovascular ailments specially in patients of coronary heart disease. A number of narrative reviews have been done but no systematic review has been conducted to date. Objective. To systematically review and conduct a meta-analysis on the available literature evaluating the efficacy of Terminalia arjuna in patients of chronic stable angina. Study selection. We included randomised, pseudo-randomized and before-after comparative studies which compared Terminalia arjuna/commercial preparation of Terminalia arjuna with current standard/ conventional treatment regimens in patients with chronic stable angina. Findings. Studies were found to be of poor methodological design. We found no significant difference in the Terminalia arjuna group as compared to control arm in the outcomes for which we were able to pool data and undertake meta-analysis. Conclusions. Currently, the evidence is insufficient to draw any definite conclusions in favour of or against Terminalia arjuna in patients of chronic stable angina. Further, well-controlled multicentric clinical trials need to be conducted in large number of patients to explore the therapeutic potential of Terminalia arjuna if any.
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors.forename: Navjot
authors.identifier: 0000-0002-5179-0773
authors.initials: N
authors.lastname: Kaur
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors.forename: Nusrat
authors.identifier: 0000-0002-1829-8701
authors.initials: N
authors.lastname: Shafiq
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors.forename: Harish
authors.identifier: 0000-0001-9264-7562
authors.initials: H
authors.lastname: Negi
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors.forename: Avaneesh
authors.identifier: 0000-0001-8035-1713
authors.initials: A
authors.lastname: Pandey
authors.affiliation: Department of Cardiology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Reddy
authors.affiliation: ICMR Advanced Centre for Evidence-Based Child Health, Advanced Paediatrics Centre, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors.forename: Harpreet
authors.initials: H
authors.lastname: Kaur
authors.affiliation: Dr. Tulsidas Library, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors.forename: Neelima
authors.initials: N
authors.lastname: Chadha
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors.forename: Samir
authors.initials: S
authors.lastname: Malhotra