title: Circumscribed acral hypokeratosis: a report of 2 cases and a brief review of the literature.
abstract: Circumscribed acral hypokeratosis (CAH) is characterized by solitary or multiple circular, depressed, slightly erythematous patches on the palms or soles. Keratinization defects on acral sites or prior trauma to the affected area have been considered as potential triggers of CAH. Although affected patients typically present with a long-term history of the disease and characteristic cutaneous lesions, CAH is not well known by dermatologists. In this article, we describe 2 patients with CAH. From a clinical point of view, we emphasize its unique cutaneous expression, and from a histologic perspective, we speculate on protracted or repetitive blunt trauma in the elicitation of this dermatosis, perhaps only in patients with a genetic predisposition.
authors.affiliation: Acıbadem Maslak Hospital, Büyükdere Caddesi 40, Maslak Sarıyer 34457, Ístanbul, Turkey. emelerkek@yahoo.com.
authors.forename: Emel
authors.initials: E
authors.lastname: Erkek
authors.forename: Emel D
authors.initials: ED
authors.lastname: Çetin
authors.forename: Engin
authors.initials: E
authors.lastname: Sezer
authors.forename: Sedef
authors.initials: S
authors.lastname: Sahin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004817:Epidermis / Q000473:pathology*; D005260:Female; D006229:Hand Dermatoses / Q000473:pathology*; D006801:Humans; D008297:Male