title: Association of the FTO gene SNP rs17817449 with body fat distribution in Mexican women.
abstract: Polymorphisms in the FTO gene are associated with obesity, body mass index, hip circumference, and visceral and subcutaneous fat area. The objective of this study was to analyze the association of the FTO rs17817449 genetic variant (T>G polymorphism) with body fat distribution patterns in women. We included 65 women and 71 healthy subjects in this study. Anthropometric parameters were determined and laboratory studies were performed. The polymorphism was detected by a PCR-RFLP method. The groups were categorized by type of body fat distribution: gynoid (N = 29) and android (N = 36). We found that the FTO gene polymorphism was not associated with body fat distribution according to the type of obesity (P > 0.05). The contribution of G and T alleles among groups indicated no statistically significant differences between the reference and gynoid group [P = 0.93; odds ratio (OR) = 0.97; 95% confidence interval (CI) = 0.46-2.02] and the reference and android group (P = 0.56; OR = 1.20; 95%CI = 0.54-2.82). Thorax circumference and thorax breast circumference were significantly different between the two groups (P = 0.009 and 0.021, respectively) with the genotype TT. We conclude that the FTO rs17817449 TT genotype predisposes individuals to fat deposition in the thoracic and breast region; individuals carrying this genotype had a decrease in thoracic and breast dimensions indirectly causing the gynoid phenotype in Mexican women.
authors.affiliation: Servicio de Cirugía Reconstructiva del Instituto Jalisciense de Cirugía Reconstructiva "Dr. José Guerrerosantos", Guadalajara, Jalisco, México.
authors.forename: J J
authors.initials: JJ
authors.lastname: Zermeño-Rivera
authors.affiliation: Servicio de Cirugía Reconstructiva del Instituto Jalisciense de Cirugía Reconstructiva "Dr. José Guerrerosantos", Guadalajara, Jalisco, México.
authors.forename: J P
authors.initials: JP
authors.lastname: Astocondor-Pérez
authors.affiliation: Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
authors.forename: Y
authors.initials: Y
authors.lastname: Valle
authors.affiliation: Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
authors.forename: J R
authors.initials: JR
authors.lastname: Padilla-Gutiérrez
authors.affiliation: Centro del Riñón, Guadalajara, Jalisco, México.
authors.forename: R
authors.initials: R
authors.lastname: Orozco-Castellanos
authors.affiliation: División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
authors.forename: L E
authors.initials: LE
authors.lastname: Figuera
authors.affiliation: División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México ethel90210@gmail.com.
authors.forename: B E
authors.initials: BE
authors.lastname: Gutiérrez-Amavizca
mesh_terms: D050154:Adiposity / Q000235:genetics*; D000328:Adult; D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D050218:Body Fat Distribution; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012307:Risk Factors
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human