title: The efficacy of oral non-steroidal anti-inflammatory drugs for rotator cuff tendinopathy: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To conduct a systematic review and meta-analysis on the efficacy of oral non-steroidal anti-inflammatory drugs for rotator cuff tendinopathy.
  
  
  METHODS
  Systematic review.
  
  
  METHODS
  A literature search was conducted in 4 databases for randomized controlled trials published until 05/2013, comparing the efficacy of oral anti-inflammatory drugs to any other intervention. Studies characteristics were extracted using a standardized form and the methodological quality was evaluated. Results were summarized qualitatively or quantitatively.
  
  
  RESULTS
  The mean methodological score of the 12 included studies was 53.6 ± 8.8%. The majority of studies included acute cases and were underpowered to detect differences in adverse events. Compared to a placebo, oral non-steroidal anti-inflammatory drugs were found to provide short-term pain relief (pooled mean difference: -2.69; 95% confidence interval: -1.96 to -3.41) but not function. Oral anti-inflammatory- drugs and corticosteroids injections have similar short-term efficacy in terms of pain reduction as well as in function (pooled standardized mean difference: 0.09; 95% confidence interval: -0.25 to 0.44).
  
  
  CONCLUSIONS
  Low to moderate grade evidence exists regarding the efficacy of non-steroidal anti-inflammatory drugs for rotator cuff tendinopathy. Oral anti-inflammatory drugs are effective in reducing short-term pain but not function. In terms of pain and function, oral anti-inflammatory drugs in the short term are as effective as corticosteroid injections.
authors.affiliation: , Orthopaedic clinical research unit, Maisonneuve-Rosemont Hospital, H1T 2M4 Montreal, Canada.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Boudreault
authors.forename: François
authors.initials: F
authors.lastname: Desmeules
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Roy
authors.forename: Clermont
authors.initials: C
authors.lastname: Dionne
authors.forename: Pierre
authors.initials: P
authors.lastname: Frémont
authors.forename: Joy C
authors.initials: JC
authors.lastname: Macdermid
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007267:Injections; D017006:Rotator Cuff; D020069:Shoulder Pain / Q000188:drug therapy* / Q000209:etiology; D052256:Tendinopathy / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D003692:Delayed-Action Preparations