title: L-type calcium channel-dependent inhibitory plasticity in the thalamus.
abstract: Thalamocortical neurons integrate sensory and cortical activity and are regulated by input from inhibitory neurons in the thalamic reticular nucleus. Evidence suggests that during bursts of action potentials, dendritic calcium transients are seen throughout the dendritic tree of thalamocortical cells. Here, we review a recent study that suggests these calcium transients regulate inhibitory input, and we attempt to reconcile studies that differ on which ion channels are the source of the calcium.
authors.affiliation: School of Physiology and Pharmacology, School of Medical Sciences, Bristol, United Kingdom; and.
authors.forename: Sarah R
authors.initials: SR
authors.lastname: Hulme
authors.affiliation: Neuroscience Division, Cardiff School of Biosciences, Cardiff, United Kingdom ConnellyWM@cf.ac.uk.
authors.forename: William M
authors.initials: WM
authors.lastname: Connelly
mesh_terms: D000818:Animals; D020746:Calcium Channels, L-Type / Q000378:metabolism*; D006801:Humans; D053444:Inhibitory Postsynaptic Potentials; D017774:Long-Term Potentiation; D013788:Thalamus / Q000378:metabolism / Q000502:physiology*
chemical_list: D020746:Calcium Channels, L-Type
keywords: GABA; L-type calcium; LTP; NOS; synaptic plasticity; thalamus