title: The lure of a LYR: The logistics of iron sulfur cluster delivery.
abstract: How are nascent iron-sulfur (Fe-S) clusters directed to specific recipient proteins? In this issue of Cell Metabolism, Maio et al. (2014) show that the mitochondrial Fe-S cochaperone protein HSC20 guides nascent Fe-S clusters based on a highly conserved motif, LYR, that exists in target proteins in different molecular contexts.
authors.affiliation: Department of Pathology and Bosch Institute, Molecular Pharmacology and Pathology Program, Blackburn Building, University of Sydney, Sydney, NSW 2006, Australia. Electronic address: darius.lane@sydney.edu.au.
authors.forename: D J R
authors.initials: DJ
authors.lastname: Lane
authors.affiliation: Department of Pathology and Bosch Institute, Molecular Pharmacology and Pathology Program, Blackburn Building, University of Sydney, Sydney, NSW 2006, Australia.
authors.forename: A M
authors.initials: AM
authors.lastname: Merlot
authors.affiliation: Department of Pathology and Bosch Institute, Molecular Pharmacology and Pathology Program, Blackburn Building, University of Sydney, Sydney, NSW 2006, Australia. Electronic address: d.richardson@sydney.edu.au.
authors.forename: D R
authors.initials: DR
authors.lastname: Richardson
mesh_terms: D006801:Humans; D007506:Iron-Sulfur Proteins / Q000378:metabolism*; D018832:Molecular Chaperones / Q000378:metabolism*
chemical_list: D007506:Iron-Sulfur Proteins; D018832:Molecular Chaperones