title: The IL-6 feed-forward loop: a driver of tumorigenesis.
abstract: IL-6 signaling plays a prominent role in tumorigenesis and metastasis. In this review we discuss the recent evidence describing the tumor intrinsic and extrinsic functions of this signaling pathway. Although blockade of this pathway in pre-clinical models leads to a reduction in tumor growth and metastasis, its clinical success is less evident. Thus, identifying the features of tumors/patients that predict response to anti-IL6 therapy are needed.
authors.affiliation: Department of Medicine, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Chang
authors.affiliation: Department of Medicine, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Daly
authors.affiliation: Department of Medicine, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY, USA; Weill Cornell Medical College (WCMC), New York, NY, USA. Electronic address: bromberj@mskcc.org.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Bromberg
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D019947:Receptors, Interleukin-6 / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D000093242:Interleukin-6 Inhibitors
chemical_list: D015850:Interleukin-6; D019947:Receptors, Interleukin-6; D000093242:Interleukin-6 Inhibitors
keywords: Cancer; Metastasis; Microenvironment