title: Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones.
abstract: The cyclocondensation of enones with aminoacetonitrile furnishes 3,4-dihydro-2H-pyrrole-2-carbonitriles which can be readily converted to 2,4-disubstituted pyrroles by microwave-induced dehydrocyanation. Alternatively, oxidation of the intermediates produces 3,5-disubstituted pyrrole-2-carbonitriles.
authors.affiliation: Institute of Organic Chemistry, Johannes Gutenberg University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
authors.forename: Murat
authors.initials: M
authors.lastname: Kucukdisli
authors.affiliation: Institute of Organic Chemistry, Johannes Gutenberg University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
authors.forename: Dorota
authors.initials: D
authors.lastname: Ferenc
authors.affiliation: Department of Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
authors.forename: Marcel
authors.initials: M
authors.lastname: Heinz
authors.affiliation: Department of Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Wiebe
authors.affiliation: Institute of Organic Chemistry, Johannes Gutenberg University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
authors.forename: Till
authors.initials: T
authors.lastname: Opatz
keywords: cyclization; heterocycles; microwave-assisted synthesis; pyrroles; α-aminonitriles