title: Brachytherapy of intra ocular tumors using 'BARC I-125 Ocu-Prosta seeds': an Indian experience.
abstract: OBJECTIVE
  To report our experience of brachytherapy using 'BARC I-125 Ocu-Prosta seeds' for the management of intraocular tumors with regard to tumor control, globe preservation visual outcome, and patient survival at Sankara Nethralaya, Chennai, India between September 2003 and May 2011.
  
  
  METHODS
  We reviewed records of 35 eyes of 35 patients who underwent ophthalmic brachytherapy between September 2003 and May 2011. Twenty-one cases had choroidal melanoma, nine had childhood retinoblastoma, two had adult-onset retinoblastoma, and there were one case each of vasoproliferative tumor, retinal angioma, and ciliary body melanoma. Brachytherapy was administered using a 15- or 20-mm gold plaque with or without a notch. Brachytherapy was the primary treatment modality in all tumors other than retinoblastoma, wherein brachytherapy was done post chemoreduction for residual tumor.
  
  
  RESULTS
  For choroidal melanomas, the mean radiation dose was 68.69 ± 15.07 (range, 47.72-94.2) Gy. The eye salvage rate was 13/20 (65%) and tumor control rate was 16/20 (80%) at an average follow-up of 24.43 ± 24.75 (range, 1.5-87.98) months. For retinoblastoma, the mean dose was 45.85 ± 3.90 (range, 39.51-50.92) Gy. The eye salvage rate and tumor control rate was 5/6 (83.3%) at an average follow-up of 38.36 ± 31.33 (range, 4.14-97.78) months. All eyes with retinoblastoma needed additional focal therapy for tumor control and eye salvage.
  
  
  CONCLUSIONS
  The results of this retrospective study confirms that the use of 'BARC I-125 Ocu-Prosta seeds' in episcleral plaques to treat intraocular tumors offers a viable option for the management of intraocular cancers.
authors.affiliation: Department of Ocular Oncology and Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India, .
authors.forename: Vikas
authors.initials: V
authors.lastname: Khetan
authors.forename: Lingam
authors.initials: L
authors.lastname: Gopal
authors.forename: Mahesh P
authors.initials: MP
authors.lastname: Shanmugam
authors.forename: Aditi
authors.initials: A
authors.lastname: Gupta
authors.forename: Tarun
authors.initials: T
authors.lastname: Sharma
authors.forename: Pramod
authors.initials: P
authors.lastname: Bhende
authors.forename: Siva
authors.initials: S
authors.lastname: Muthukumar
authors.forename: R
authors.initials: R
authors.lastname: Subramaniam
authors.forename: Thayalan
authors.initials: T
authors.lastname: Kuppuswamy
authors.forename: S K
authors.initials: SK
authors.lastname: Saxena
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Dash
mesh_terms: D000328:Adult; D001918:Brachytherapy / Q000295:instrumentation*; D004307:Dose-Response Relationship, Radiation; D004867:Equipment Design; D005134:Eye Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India / Q000453:epidemiology; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes