title: [Molecular-genetic characteristics of Mycobacterium tuberculosis strains isolated from patients with tuberculous spondylitis].
abstract: OBJECTIVE
  Molecular-genetic characteristic of M. tuberculosis strains isolated from operation material of patients with tuberculous spondylitis.
  
  
  METHODS
  107 strains of M. tuberculosis isolated in 2007 - 2011 from patients with spine tuberculosis were studied by methods of spoligotyping and MIRU-VNTR by 12 and 24 loci.
  
  
  RESULTS
  Strains of genetic family Beijing dominated (n = 80), 78% of those had multiple drug resistance (MDR). Strains of genetic families T, H3 (Ural), LAM, Manu, H4 and S were also detected. Differentiating of 80 strains of Beijing genotype by MIRU-VNTR method by 24 loci revealed 24 variants (HGI = 0.83) including 7 clusters, the largest of those (100-32) included 23 strains (87% MDR).
  
  
  CONCLUSIONS
  The leading role of Beijing genotype M. tuberculosis strains in development of tuberculous spondylitis with multiple drug resistance of the causative agent is shown.
authors.forename: A A
authors.initials: AA
authors.lastname: Viazovaia
authors.forename: N S
authors.initials: NS
authors.lastname: Solov'eva
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Zhuravlev
authors.forename: I V
authors.initials: IV
authors.lastname: Mokrousov
authors.forename: O A
authors.initials: OA
authors.lastname: Manicheva
authors.forename: B I
authors.initials: BI
authors.lastname: Vishnevskiĭ
authors.forename: O V
authors.initials: OV
authors.lastname: Narvskaia
mesh_terms: D005260:Female; D056426:Genetic Loci; D014644:Genetic Variation; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification; D013166:Spondylitis / Q000235:genetics* / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000235:genetics*; D014399:Tuberculosis, Spinal / Q000235:genetics* / Q000382:microbiology