title: Polyoxometalate clusters integrated into peptide chains and as inorganic amino acids: solution- and solid-phase approaches.
abstract: General synthetic methods for the grafting of peptide chains onto polyoxometalate clusters by the use of general activated precursors have been developed. Using a solution-phase approach, pre-synthesized peptides can be grafted to a metal oxide cluster to produce hybrids of unprecedented scale (up to 30 residues). An adapted solid-phase method allows the incorporation of these clusters, which may be regarded as novel hybrid unnatural amino acids, during the peptide synthesis itself. These methods may open the way for the automated synthesis of peptides and perhaps even proteins that contain "inorganic" amino acids.
authors.affiliation: WestCHEM, School of Chemistry, The University of Glasgow, University Avenue, Glasgow G12 8QQ (UK) http://www.croninlab.com.
authors.forename: Carine
authors.initials: C
authors.lastname: Yvon
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Surman
authors.forename: Marie
authors.initials: M
authors.lastname: Hutin
authors.forename: Jennifer
authors.initials: J
authors.lastname: Alex
authors.forename: Brian O
authors.initials: BO
authors.lastname: Smith
authors.forename: De-Liang
authors.initials: DL
authors.lastname: Long
authors.forename: Leroy
authors.initials: L
authors.lastname: Cronin
mesh_terms: D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*; D017973:Tungsten Compounds / Q000737:chemistry*; D000099294:Polyoxometalates
chemical_list: D010455:Peptides; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates
keywords: hybrid clusters; peptides; polyoxometalates; solid-phase synthesis; unnatural amino acids