title: First case of atypical takotsubo cardiomyopathy in a bilateral lung-transplanted patient due to acute respiratory failure.
abstract: Takotsubo cardiomyopathy which is characterised by a transient left ventricular wall motion abnormality was first described in 1990. The disease is still not well known, and as such it is suggested that an emotional trigger is mandatory in this disease. We present the case of a 51-year old female patient seven years after bilateral lung transplantation, who developed acute respiratory distress syndrome and subsequently suffered from atypical takotsubo cardiomyopathy with transient severe reduction of ejection fraction and haemodynamic instability needing acute intensive care treatment. Acute respiratory failure has emerged as an important physical trigger factor in takotsubo cardiomyopathy. Little is known about the association of hypoxia and takotsubo cardiomyopathy which can elicit a life-threatening condition requiring acute intensive care. Therefore, experimental studies are needed to investigate the role of hypoxia in takotsubo cardiomyopathy.
authors.affiliation: Department of Cardiology, University Hospital Zurich, Switzerland.
authors.forename: Jelena R
authors.initials: JR
authors.lastname: Ghadri
authors.affiliation: Department of Cardiology, University Hospital Zurich, Switzerland.
authors.forename: Roxana D
authors.initials: RD
authors.lastname: Bataisou
authors.affiliation: Department of Cardiology, University Hospital Zurich, Switzerland.
authors.forename: Johanna
authors.initials: J
authors.lastname: Diekmann
authors.affiliation: Department of Cardiology, University Hospital Zurich, Switzerland Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Lüscher
authors.affiliation: Department of Cardiology, University Hospital Zurich, Switzerland Christian.templin@usz.ch.
authors.forename: Christian
authors.initials: C
authors.lastname: Templin
mesh_terms: D003402:Creatine Kinase / Q000097:blood; D003422:Critical Care / Q000592:standards; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D012131:Respiratory Insufficiency / Q000097:blood / Q000150:complications* / Q000601:surgery*; D054549:Takotsubo Cardiomyopathy / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000523:psychology; D014336:Troponin / Q000097:blood
chemical_list: D014336:Troponin; D020097:Natriuretic Peptide, Brain; D003402:Creatine Kinase
keywords: Takotsubo cardiomyopathy; acute cardiac care; heart failure; hypoxia