title: BCL2DB: database of BCL-2 family members and BH3-only proteins.
abstract: BCL2DB (http://bcl2db.ibcp.fr) is a database designed to integrate data on BCL-2 family members and BH3-only proteins. These proteins control the mitochondrial apoptotic pathway and probably many other cellular processes as well. This large protein group is formed by a family of pro-apoptotic and anti-apoptotic homologs that have phylogenetic relationships with BCL-2, and by a collection of evolutionarily and structurally unrelated proteins characterized by the presence of a region of local sequence similarity with BCL-2, termed the BH3 motif. BCL2DB is monthly built, thanks to an automated procedure relying on a set of homemade profile HMMs computed from seed reference sequences representative of the various BCL-2 homologs and BH3-only proteins. The BCL2DB entries integrate data from the Ensembl, Ensembl Genomes, European Nucleotide Archive and Protein Data Bank databases and are enriched with specific information like protein classification into orthology groups and distribution of BH motifs along the sequences. The Web interface allows for easy browsing of the site and fast access to data, as well as sequence analysis with generic and specific tools. BCL2DB provides a helpful and powerful tool to both 'BCL-2-ologists' and researchers working in the various fields of physiopathology. Database URL: http://bcl2db.ibcp.fr.
authors.affiliation: Unité Bases Moléculaires et Structurales des Systèmes Infectieux, UMR 5086 CNRS - Université Claude Bernard Lyon 1, IBCP - 7, passage du Vercors, 69367 Lyon cedex 07, France and Molecular Biology of the Cell Laboratory, Ecole Normale Supérieure de Lyon, LBMC UMR 5239 CNRS - UCBL - HCL - ENS Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
authors.forename: Valentine
authors.initials: V
authors.lastname: Rech de Laval
authors.forename: Gilbert
authors.initials: G
authors.lastname: Deléage
authors.forename: Abdel
authors.initials: A
authors.lastname: Aouacheria
authors.forename: Christophe
authors.initials: C
authors.lastname: Combet
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D058977:Molecular Sequence Annotation; D008969:Molecular Sequence Data; D005810:Multigene Family; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000378:metabolism*; D014584:User-Computer Interface
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2