title: The prevalence of dogs with lymphocyte proliferative responses to food allergens in canine allergic dermatitis.
abstract: The aim of the present study was to examine the correlation between the results of lymphocyte proliferative test (LPT) specific to food allergens and allergic skin diseases in dogs. Investigations were performed in 138 dogs with allergic skin diseases diagnosed in a private animal hospital. Of the 138 animals, 97 cases had positive reactions in LPT specific to food allergens. Of these 97 dogs, 67 animals were diagnosed with canine atopic dermatitis (CAD), but 30 dogs did not have IgE antibodies to environmental allergens. As 14 dogs out of 30 animals showed a positive result, 12 dogs underwent elimination diet trial based on the test results and all of them showed improvement in the pruritus score. Therefore, we conclude that LPT is an effective diagnostic test for allergic skin disease. Results of the lymphocyte test are useful in the identification of food allergens for the elimination diet trial.
authors.affiliation: Primo Animal Hospital, Sagamihara Chuo, 4-11-45 Higashifuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-0203, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kawano
authors.affiliation: Primo Animal Hospital, Sagamihara Chuo, 4-11-45 Higashifuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-0203, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Oumi
authors.affiliation: Primo Animal Hospital, Sagamihara Chuo, 4-11-45 Higashifuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-0203, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ashida
authors.affiliation: Department of Microbiology, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Saitama 350-0495, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Horiuchi
authors.affiliation: Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi 753-8515, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mizuno
mesh_terms: D000485:Allergens / Q000494:pharmacology*; D000818:Animals; D049109:Cell Proliferation; D003872:Dermatitis / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D005260:Female; D005512:Food Hypersensitivity / Q000662:veterinary*; D007073:Immunoglobulin E / Q000378:metabolism; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D008297:Male; D012189:Retrospective Studies
chemical_list: D000485:Allergens; D007073:Immunoglobulin E