title: Attenuation of serum ferritin and iron burden by intake of antioxidants in beta thalassemia major.
abstract: It has been anticipated that iron and ferritin burden in patients with beta thalassemia major is associated with enhanced free radical formation and blemished antioxidant defense system. The goal of study was to scrutinize impact of serum iron, total iron binding capacity (TIBC), ferritin and erythrocyte catalase in patients with beta thalassemia major. 140 beta thalassemia major patients were studied before and after supplementation of antioxidants for one month, and status was compared with 140 age and sex matched healthy controls. A significant elevation was found in the levels of serum iron and ferritin (P < 0.001) with concomitant decrease in erythrocyte catalase (P < 0.001) in patients when compared with controls. After one month supplementation of antioxidants, catalase was elevated significantly (P < 0.001) and marginal rise in serum TIBC concentration increased marginally while iron and ferritin were decreased marginally (P > 0.05) when compared with controls and baselines values. Beta thalassemia major children receive multiple blood transfusions, and are at risk of secondary iron overload induced oxidative stress. These effects may be help to minimize with supplementation of antioxidants.
authors.forename: Sonali S
authors.initials: SS
authors.lastname: Bhagat
authors.forename: Purnima Dey
authors.initials: PD
authors.lastname: Sarkar
authors.forename: Adinath N
authors.initials: AN
authors.lastname: Suryakar
authors.forename: Ramchandra K
authors.initials: RK
authors.lastname: Padalkar
authors.forename: Rahul A
authors.initials: RA
authors.lastname: Ghone
authors.forename: Sangita M
authors.initials: SM
authors.lastname: Patil
authors.forename: Prakash S
authors.initials: PS
authors.lastname: Hundekar
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage*; D001803:Blood Transfusion; D002374:Catalase / Q000097:blood; D019587:Dietary Supplements; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood*; D019190:Iron Overload / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress; D017086:beta-Thalassemia / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D005293:Ferritins; D007501:Iron; D002374:Catalase