title: Computational approaches and resources in single amino acid substitutions analysis toward clinical research.
abstract: Single amino acid substitutions (SAPs) belong to a class of SNPs in the coding region, which alter the protein function during the translation process. Storage of more information regarding SAPs in public databases will soon become a major hurdle in characterizing the functional SAPs. In such a demanding era, biology has to rely on bioinformatics, which can work its way through to solve the problems at hand by cutting huge amount of time and resources that are otherwise wasted. Here, we describe an overview of the existing repositories of variant databases and computational methods in predicting the effects of functional SAPs on protein stability, structure, function, drug response, and protein dynamics. This chapter will inspire many biologists with a greater promise in identifying the functional SAPs at the structural level, thereby understanding the molecular effects that are critical for personalized medicine diagnosis, prognosis, and treatment for diseases.
authors.affiliation: Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India. Electronic address: georgecp77@yahoo.co.in.
authors.forename: C
authors.initials: C
authors.lastname: George Priya Doss
authors.affiliation: Department of Bio-Informatics, School of Computer and Information Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
authors.affiliation: BioMolecules & Genetics Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India.
authors.forename: Vaishnavi
authors.initials: V
authors.lastname: Narayan
authors.affiliation: Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India.
authors.forename: D
authors.initials: D
authors.lastname: Thirumal Kumar
mesh_terms: D019943:Amino Acid Substitution; D035843:Biomedical Research; D006801:Humans; D056004:Molecular Dynamics Simulation; D010641:Phenotype
keywords: Deleterious; Docking; Homology modeling; Molecular dynamics; SNPs; Single amino acid substitutions