title: Association of Zinc, Copper and Magnesium with bone mineral density in Iranian postmenopausal women - a case control study.
abstract: BACKGROUND
  The risk of inadequate nutrition such as trace elements and vitamin deficiencies is considerable in postmenopausal women. The aim of this study was to compare trace elements (Zinc, Copper and Magnesium) concentration in nail, urine and serum among osteoporotic postmenopausal women with control group in Iran.
  
  
  METHODS
  Forty eight postmenopausal women aged 36-60 years, were recruited, consisting 30 osteoporotic patients and 18 healthy controls. Blood, nail and urine concentration of Zinc (Zn), copper (Cu) and magnesium (Mg) were determined using Inductively Coupled Plasma -Atomic Emission Spectrometry (ICP-AES) method. Their Bone Mineral Density was measured by Dual X-ray Absorption (DEXA) method.
  
  
  RESULTS
  The urine level of trace elements had significant difference between osteoporotic groups and controls (p < 0.001). Moreover Mg level significantly differed in serum between two groups (p < 0.04). There was no statistically significant difference in trace minerals in nail beyond groups.
  
  
  CONCLUSIONS
  Our findings indicate that Urine Zn level could be considerable an appropriate marker for bone absorption, usage of Zn supplements in postmenopausal women may result a beneficial reduction in osteoporotic risk.
authors.forename: Rezvan
authors.initials: R
authors.lastname: Razmandeh
authors.forename: Ensieh
authors.initials: E
authors.lastname: Nasli-Esfahani
authors.forename: Reza
authors.initials: R
authors.lastname: Heydarpour
authors.forename: Farnoush
authors.initials: F
authors.lastname: Faridbod
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Ganjali
authors.forename: Parviz
authors.initials: P
authors.lastname: Norouzi
authors.affiliation: Diabetes Researcher Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. emrc@sina.tums.ac.ir.
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.forename: Davood
authors.initials: D
authors.lastname: Khoda-Amorzideh