title: Syndrome in question. Brooke-Spiegler syndrome.
abstract: Brooke-Spiegler syndrome is an autosomal dominant disorder with variable penetrance and expression. It is characterized by a genetic predisposition to develop multiple adnexal neoplasias: cylindromas, trichoepitheliomas, and trichoblastomas. We describe a 54-year-old male patient with cylindromas, trichoepitheliomas, and trichoblastoma.
authors.affiliation: MD, dermatologist at private clinic - Rio de Janeiro (RJ), Brazil.
authors.forename: Fernanda Guedes
authors.initials: FG
authors.lastname: Lavorato
authors.affiliation: State University of Rio de Janeiro, Teaching Hospital Pedro Ernesto, Rio de JaneiroRJ, Brazil, MD, specialist in Dermatology, Teaching Hospital Pedro Ernesto - State University of Rio de Janeiro (Universidade do Estado do Rio de Janeiro) (HUPE-UERJ) - Rio de Janeiro (RJ), Brazil.
authors.forename: Marcela Duarte Benez
authors.initials: MD
authors.lastname: Miller
authors.affiliation: State University of Rio de Janeiro, Hospital Pedro Ernesto, Dermatology Service, BenficaRJ, Brazil, MD, dermatologist - Assistant Professor of Dermatopathology, Dermatology Service, Teaching Hospital Pedro Ernesto - State University of Rio de Janeiro (Universidade do Estado do Rio de Janeiro - HUPE-UERJ). Professor, head of the discipline of Dermatopathology at the Tropical Dermatology Service, Central Army Hospital (Hospital Central do Exército - HCE) - Benfica (RJ), Brazil.
authors.forename: Daniel Lago
authors.initials: DL
authors.lastname: Obadia
authors.affiliation: MD, dermatologist at private clinic - Brasília (DF), Brazil.
authors.forename: Natália Solon
authors.initials: NS
authors.lastname: Nery
authors.affiliation: State University of Rio de Janeiro, Hospital Pedro Ernesto, Rio de JaneiroRJ, Brazil, MD,Preceptor of the Dermatology Service, Teaching Hospital Pedro Ernesto - State University of Rio de Janeiro (Universidade do Estado do Rio de Janeiro - HUPE-UERJ). Researcher at the Laboratory of Histocompatibility and Criopreservation - State University of Rio de Janeiro (Universidade do Estado do Rio de Janeiro - HLA-UERJ) - Rio de Janeiro (RJ), Brazil.
authors.forename: Roberto Souto da
authors.initials: RS
authors.lastname: Silva
mesh_terms: D001706:Biopsy; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*