title: Please keep me 2uned to PKM2.
abstract: In this issue of Molecular Cell, Keller et al. (2014) found that binding of the metabolite SAICAR to PKM2 induces the protein kinase activity of an enzyme normally designed to terminate the glycolytic pathway.
authors.affiliation: Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9152, USA. Electronic address: steven.mcknight@utsouthwestern.edu.
authors.forename: Steven L
authors.initials: SL
authors.lastname: McKnight
mesh_terms: D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000737:chemistry; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D047428:Protein Kinase Inhibitors / Q000737:chemistry*; D012265:Ribonucleotides / Q000737:chemistry*; D015398:Signal Transduction; D013963:Thyroid Hormones / Q000378:metabolism*; D000097810:Thyroid Hormone-Binding Proteins
chemical_list: D000620:Aminoimidazole Carboxamide; D002352:Carrier Proteins; D008565:Membrane Proteins; D047428:Protein Kinase Inhibitors; D012265:Ribonucleotides; D013963:Thyroid Hormones; D000097810:Thyroid Hormone-Binding Proteins; C020635:SAICAR