title: Using rigidly fixed autogenous tooth graft to repair bone defect: an animal model.
abstract: OBJECTIVE
  This study describes a new approach to regenerate bone defect using autogenous tooth.
  
  
  METHODS
  Freshly extracted teeth were used as autogenous grafts. Teeth were sectioned, cut into desired shape, and disinfected. The grafts were rigidly fixed to the mandibular defects in eighteen rabbits using titanium screws to achieve good stability. Every six rabbits were stochastically sacrificed at 1, 3, and 6 months after implantation, respectively. For all specimens, clinical, radiographical, and histological measurements were performed.
  
  
  RESULTS
  The boundaries of the grafts were distinctly visible in the implanted area during the first and third month. However, the teeth grafts were fully covered by new bone by the sixth month. The radiograph demonstrated the progressive change in the bone and grafted tooth interface from radiolucency to radiopacity during different time periods. Histologically, vascularization led to a temporary fibrous integration in the graft-bone interface. The bone contact rate of 1 and 3 months was significantly lower than that of the 6 months. During this period, grafts were gradually resorbed and replaced by new bone.
  
  
  CONCLUSIONS
  Rigid fixation of autogenous tooth could serve as a novel approach for the repair of bone defect.
authors.affiliation: Department of Stomatology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Xu
authors.identifier: http://orcid.org/0000-0003-0732-9397
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Stomatology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.|Ministry of Health, Kathmandu, Nepal.
authors.forename: Regmi M
authors.initials: RM
authors.lastname: Raj
authors.affiliation: Department of Stomatology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Xiao-Fu
authors.initials: XF
authors.lastname: Liao
authors.affiliation: Department of Stomatology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.affiliation: Department of Stomatology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Ma
authors.affiliation: Department of Stomatology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Shi-Qiang
authors.initials: SQ
authors.lastname: Gong
authors.affiliation: Department of Stomatology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Chen
authors.affiliation: Department of Stomatology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities*; D023421:Models, Animal; D011817:Rabbits; D014070:Tooth / Q000637:transplantation*
keywords: ankylosis; bone graftings; bone regeneration; tooth