title: Biodentine™ material characteristics and clinical applications: a review of the literature.
abstract: BACKGROUND
  Biodentine™ is a new version of calcium silicate-based inorganic cement.
  
  
  OBJECTIVE
  The aim of this review is to provide a detailed analysis of the physical and biological properties of Biodentine™ and to compare these properties with those of other tricalcium silicate cements viz. mineral trioxide aggregate (MTA) and Bioaggregate™ (Bioaggregate).
  
  
  METHODS
  A comprehensive systematic literature search for all publications to date was performed on 20th November 2013 by two independent reviewers in Medline (PubMed), Embase, Web of Science, CENTRAL (Cochrane), SIGLE, SciELO, Scopus, Lilacs and clinicaltrials.gov using the search terms Biodentine, "tricalcium silicate", Ca3SiO5, "dentine substitute", "dentin substitute" and RD 94. In addition to the electronic search, hand searches and reference searches were performed to include articles published in journals that were not indexed in Medline. Randomised control trials (RCT), case control studies, case series, case reports, in vitro studies, animal studies and short communications in English language were considered for this review.
  
  
  CONCLUSIONS
  Considering the superior physical and biologic properties, Biodentine™ could be an efficient alternative to MTA to be used in a variety of clinical applications. There appears to be a wide range of clinical applications where Biodentine™ could be used in the field of endodontics, dental traumatology, restorative dentistry and pediatric dentistry. Although it seems to be good clinical practice, currently there is little clinical evidence to support all potential indications.
authors.affiliation: Department of Paediatric Dentistry and Special Care, PaeCaMeD Research, Dental School, P8, Ghent University Hospital, Ghent University, UZ Ghent, 1P8, De Pintelaan 185, 9000, Ghent, Belgium, sivaprakash.rajasekharan@ugent.be.
authors.forename: S
authors.initials: S
authors.lastname: Rajasekharan
authors.forename: L C
authors.initials: LC
authors.lastname: Martens
authors.forename: R G E C
authors.initials: RG
authors.lastname: Cauwels
authors.forename: R M H
authors.initials: RM
authors.lastname: Verbeeck
mesh_terms: D017607:Aluminum Compounds / Q000737:chemistry / Q000627:therapeutic use; D017610:Calcium Compounds / Q000737:chemistry* / Q000627:therapeutic use; D002126:Calcium Hydroxide / Q000737:chemistry / Q000627:therapeutic use; D055598:Chemical Phenomena; D004338:Drug Combinations; D006801:Humans; D006882:Hydroxyapatites / Q000737:chemistry / Q000627:therapeutic use; D055595:Mechanical Phenomena; D010087:Oxides / Q000737:chemistry / Q000627:therapeutic use; D012387:Root Canal Filling Materials / Q000737:chemistry* / Q000627:therapeutic use; D017640:Silicates / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D017607:Aluminum Compounds; C557009:BioAggregate; D017610:Calcium Compounds; D004338:Drug Combinations; D006882:Hydroxyapatites; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; C506393:tricalcium silicate; D002126:Calcium Hydroxide