title: The local lymph node assay in 2014.
abstract: Toxicology endeavors to predict the potential of materials to cause adverse health (and environmental) effects and to assess the risk(s) associated with exposure. For skin sensitizers, the local lymph node assay was the first method to be fully and independently validated, as well as the first to offer an objective end point with a quantitative measure of sensitizing potency (in addition to hazard identification). Fifteen years later, it serves as the primary standard for the development of in vitro/in chemico/in silico alternatives.
authors.affiliation: From *DABMEB Consultancy Ltd, Sharnbrook, Bedfordshire, United Kingdom; †Procter & Gamble, Mason, Cincinnati, OH; and ‡Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: David A
authors.initials: DA
authors.lastname: Basketter
authors.forename: G Frank
authors.initials: GF
authors.lastname: Gerberick
authors.forename: Ian
authors.initials: I
authors.lastname: Kimber
mesh_terms: D000485:Allergens / Q000008:administration & dosage*; D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000209:etiology; D023441:Local Lymph Node Assay; D051379:Mice; D018570:Risk Assessment / Q000379:methods; D014116:Toxicology
chemical_list: D000485:Allergens