title: Secondary amenorrhea despite normal endometrial development with secretory changes and absence of uterine synechiae -- a second case of the endometrial compaction-apoptosis syndrome.
abstract: OBJECTIVE
  To report the second case of amenorrhea related to endometrial compaction apoptosis syndrome.
  
  
  METHODS
  A female with secondary amenorrhea was evaluated with sonography, hysteroscopy, serum estradiol and progesterone levels, serum luteinizing hormone (LH), follicle stimulating hormone (FSH), and endometrial biopsy.
  
  
  RESULTS
  Initially she was found to be ovulatory. However she did not menstruate despite the development of adequate endometrial thickness and a normal secretory endometrial biopsy. Hysterosalpingogram failed to detect synechial. Subsequently she developed hypogonadotropic hypogonadism, but she still failed to menstruate despite estrogen followed by progesterone.
  
  
  CONCLUSIONS
  Amenorrhea can occur despite secretory endometrial changes without a uterine abnormality.
authors.affiliation: The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. laurie@ccivf.com
authors.forename: J H
authors.initials: JH
authors.lastname: Check
authors.affiliation: Philadelphia College of Osteopathic Medicine, Department of Obstetrics and Gynecology, Philadelphia, PA,USA.
authors.forename: R
authors.initials: R
authors.lastname: Cohen
mesh_terms: D000568:Amenorrhea / Q000209:etiology*; D017209:Apoptosis; D001706:Biopsy; D004717:Endometrium / Q000473:pathology; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000209:etiology; D015907:Hysteroscopy; D007986:Luteinizing Hormone / Q000097:blood; D010060:Ovulation; D011374:Progesterone / Q000008:administration & dosage / Q000097:blood; D013577:Syndrome; D014463:Ultrasonography; D014591:Uterine Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D055815:Young Adult
chemical_list: D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone