title: Meta-analyses between 18 candidate genetic markers and overweight/obesity.
abstract: OBJECTIVE
  The goal of our study is to investigate the associations between 18 candidate genetic markers and overweight/obesity.
  
  
  METHODS
  A total of 72 eligible articles were retrieved from literature databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Meta-analyses of 18 genetic markers among 56,738 controls and 48,148 overweight/obese persons were done by Review Manager 5.0.
  
  
  RESULTS
  Our results showed that SH2B1 rs7498665 polymorphism was significantly associated with the risk of overweight/obesity (overall odds ratio (OR) = 1.21, 95% confidence interval (CI) = 1.09-1.34, P = 0.0004). Increased risk of overweight/obesity was also observed in FAIM2 rs7138803 polymorphism (overall OR = 1.11, 95% CI = 1.01-1.22, P = 0.04).
  
  
  CONCLUSIONS
  Our meta-analyses have shown the important role of 2 polymorphisms (SH2B1 rs7498665 and FAIM2 rs7138803) in the development of overweight/obesity. This study highlighted the importance of above two candidate genes (SH2B1 and FAIM2) in the risk of overweight/obesity.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2785487401176182.
authors.forename: Linlin
authors.initials: L
authors.lastname: Tang
authors.forename: Huadan
authors.initials: H
authors.lastname: Ye
authors.forename: Qingxiao
authors.initials: Q
authors.lastname: Hong
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Qinwen
authors.initials: Q
authors.lastname: Wang
authors.forename: Leiting
authors.initials: L
authors.lastname: Xu
authors.forename: Shizhong
authors.initials: S
authors.lastname: Bu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 315211 Ningbo, Zhejiang, China. yemeng@nbu.edu.cn.
authors.forename: Meng
authors.initials: M
authors.lastname: Ye
authors.forename: Dao Wen
authors.initials: DW
authors.lastname: Wang
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Mai
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D050177:Overweight / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; C400427:FAIM2 protein, human; D008565:Membrane Proteins; C518910:SH2B1 protein, human