title: Synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids.
abstract: The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin-glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.
authors.affiliation: Department of Chemistry, Yonsei University.
authors.forename: Dongguk
authors.initials: D
authors.lastname: Min
authors.forename: Minkyu
authors.initials: M
authors.lastname: Kim
authors.forename: Jérémy
authors.initials: J
authors.lastname: Ricci
authors.forename: Sora
authors.initials: S
authors.lastname: Jung
authors.forename: Kirim
authors.initials: K
authors.lastname: Kim
authors.forename: Won-Yoon
authors.initials: WY
authors.lastname: Chung
authors.forename: Kwang-Kyun
authors.initials: KK
authors.lastname: Park
authors.forename: Mankil
authors.initials: M
authors.lastname: Jung
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D037621:Artemisinins / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006017:Glycolipids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D037621:Artemisinins; D006017:Glycolipids; C063801:deoxoartemisinin