title: Femtosecond laser-assisted intracorneal biopolymer insertion for the symptomatic treatment of bullous keratopathy.
abstract: OBJECTIVE
  To describe a new minimally invasive surgical technique for the symptomatic management of bullous keratopathy in blind eyes.
  
  
  METHODS
  Four patients with severe corneal edema due to endothelial decompensation and no visual function in the affected eye presented for the relief of their ocular symptoms (pain and tearing). Femtosecond laser technology was used to create a deep corneal pocket into which silicone oil was inserted.
  
  
  RESULTS
  After the procedure, all patients demonstrated immediate relief of their symptoms, along with restoration of a normal corneal surface 7 days after the procedure (no bullae and no epithelial defects). All patients remained free of symptoms during the entire follow-up period (from 24 to 31 months). Anterior to the inserted implant, the corneal lamellae remained compact, transparent, and without bullae; whereas the posterior corneal stroma under the implant was edematous. No intraoperative or postoperative complications were noted.
  
  
  CONCLUSIONS
  Intracorneal insertion of silicone oil is a feasible new technique for the symptomatic treatment of bullous keratopathy in blind eyes.
authors.affiliation: *Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete, Greece; and †Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL.
authors.forename: George D
authors.initials: GD
authors.lastname: Kymionis
authors.forename: Vasilios F
authors.initials: VF
authors.lastname: Diakonis
authors.forename: Vardhaman P
authors.initials: VP
authors.lastname: Kankariya
authors.forename: Argyro D
authors.initials: AD
authors.lastname: Plaka
authors.forename: Sofia I
authors.initials: SI
authors.lastname: Panagopoulou
authors.forename: George A
authors.initials: GA
authors.lastname: Kontadakis
authors.forename: Michael A
authors.initials: MA
authors.lastname: Grentzelos
authors.forename: Miltiades K
authors.initials: MK
authors.lastname: Tsilimbaris
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Pallikaris
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001768:Blister / Q000628:therapy*; D002908:Chronic Disease; D015715:Corneal Edema / Q000628:therapy*; D003319:Corneal Stroma / Q000187:drug effects / Q000601:surgery*; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000150:complications; D005902:Glaucoma, Open-Angle / Q000150:complications; D006801:Humans; D053685:Laser Therapy; D008297:Male; D019060:Minimally Invasive Surgical Procedures; D012827:Silicone Oils / Q000008:administration & dosage*; D013524:Surgical Flaps; D041623:Tomography, Optical Coherence
chemical_list: D012827:Silicone Oils; C539721:oxane HD