title: Copper-catalyzed benzylic C(sp(3))-H alkoxylation of heterocyclic compounds.
abstract: We achieved intra- and intermolecular C(sp(3))-H alkoxylation of benzylic positions of heteroaromatic compounds using CuBrn (n = 1, 2)/5,6-dimethylphenanthroline (or 4,7-dimethoxyphenanthroline) and ((t)BuO)2 as a catalyst and an oxidant, respectively. The reaction proceeded at both terminal and internal benzylic positions of the alkyl groups. The intramolecular alkoxylation was performed on a gram scale.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. kuninobu@mol.f.u-tokyo.ac.jp kanai@mol.f.u-tokyo.ac.jp.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Takemura
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kuninobu
authors.forename: Motomu
authors.initials: M
authors.lastname: Kanai
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000438:Alcohols; D006571:Heterocyclic Compounds; D003300:Copper