title: Protein expression changes in cells inoculated with equine influenza virus: antibody microarray analysis.
abstract: Changes in the level of cellular proteins in cells inoculated with equine influenza virus H7N7 and H3N8 were studied with microarray technique. H3N8 induced pro-apoptotic proteins while H7N7 induced both pro- as well as anti-apoptotic factors. The higher level of some cytoskeleton components and proteins involved in the protein quality control was recorded. Relatively high number of proteins involved in the regulation of transcription was down-regulated. The pattern of changes observed for H7N7 and H3N8 may reflect differences in the biological properties of both serotypes.
authors.affiliation: Department of Virology, National Veterinary Research Institute, Al. Partyzantow 57, 24-100 Pulawy, Poland. wrozek@piwet.pulawy.pl
authors.forename: W
authors.initials: W
authors.lastname: Rozek
authors.affiliation: Department of Virology, National Veterinary Research Institute, Al. Partyzantow 57, 24-100 Pulawy, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Kwasnik
authors.affiliation: Department of Virology, National Veterinary Research Institute, Al. Partyzantow 57, 24-100 Pulawy, Poland.
authors.forename: J F
authors.initials: JF
authors.lastname: Zmudzinski
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000914:Antibodies, Viral / Q000235:genetics / Q000378:metabolism*; D005434:Flow Cytometry; D005786:Gene Expression Regulation / Q000276:immunology*; D053123:Influenza A Virus, H3N8 Subtype; D051379:Mice; D046888:Tissue Array Analysis / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral