title: Macrophages in solid organ transplantation.
abstract: Macrophages are highly plastic hematopoietic cells with diversified functions related to their anatomic location and differentiation states. A number of recent studies have examined the role of macrophages in solid organ transplantation. These studies show that macrophages can induce allograft injury but, conversely, can also promote tissue repair in ischemia-reperfusion injury and acute rejection. Therapeutic strategies that target macrophages to improve outcomes in solid organ transplant recipients are being examined in preclinical and clinical models. In this review, we discuss the role of macrophages in different types of injury and rejection, with a focus on macrophage-mediated tissue injury, specifically vascular injury, repair and remodeling. We also discuss emerging macrophage-centered therapeutic opportunities in solid organ transplantation.
authors.affiliation: Department of Medicine, VA Palo Alto Health Care System/Division of Pulmonary/Critical Care, Stanford University School of Medicine, Stanford, CA 94304, USA. xinguoj@stanford.edu.
authors.forename: Xinguo
authors.initials: X
authors.lastname: Jiang
authors.forename: Wen
authors.initials: W
authors.lastname: Tian
authors.forename: Yon K
authors.initials: YK
authors.lastname: Sung
authors.forename: Jin
authors.initials: J
authors.lastname: Qian
authors.forename: Mark R
authors.initials: MR
authors.lastname: Nicolls