title: Do platelet indices have a role in benign paroxysmal positional vertigo?
abstract: OBJECTIVE
  Benign paroxysmal positional vertigo (BPPV) is a frequently encountered condition that can severely affect quality of life. Present study was undertaken to investigate whether the platelet (PLT) indices, including mean platelet volume (MPV), platelet distribution width (PDW), and platelet crit (PCT), could serve as diagnostic tools in patients with BPPV.
  
  
  METHODS
  Consecutive 45 BPPV patients and age- and sex-matched 40 control subjects were enrolled in this cross-sectional prospective study. Benign paroxysmal positional vertigo patients underwent a complete audio-vestibular test battery including Dix-Hallpike maneuver. Routine laboratory analyses were performed in both of the groups.
  
  
  RESULTS
  In BPPV patients, PLT, MPV, and PDW were found significantly higher than in controls (P < 0·05). Platelet and mean platelet volume were independently associated with BPPV (P  =  0·002 and P < 0·001, respectively). Platelet and platelet crit were significantly higher in patients with BPPV involving the left labyrinth than in those with the right affected side (P < 0·05). Mean platelet volume and platelet distribution width were to be significantly higher in the BPPV patients with recurrent vertigo attack than in those with first-ever attack (P < 0·001). A cutoff value of 8·75 for MPV and 16·65 for PDW parameters were obtained to identify the recurrence in BPPV patients in the receiving operating characteristic (ROC) analysis.
  
  
  CONCLUSIONS
  Elevated PLT indices were associated with BPPV requiring further efforts to better clarify this issue.
authors.forename: Asuman
authors.initials: A
authors.lastname: Celikbilek
authors.forename: Nermin
authors.initials: N
authors.lastname: Tanik
authors.forename: Gokmen
authors.initials: G
authors.lastname: Zararsiz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Celikbilek
mesh_terms: D000328:Adult; D065635:Benign Paroxysmal Positional Vertigo / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D001772:Blood Cell Count; D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D010976:Platelet Count; D011446:Prospective Studies
keywords: Benign paroxysmal positional vertigo,; Mean platelet volume,; Platelet crit,; Platelet distribution width,; Platelet indices; Platelet,