title: Pseudo-Meigs' syndrome associated with hydropic degenerating uterine leiomyoma: a case report.
abstract: Pseudo-Meigs' syndrome secondary to uterine leiomyoma is a rare entity. A 50-year-old Japanese woman presented with a 3-month history of shortness of breath. Chest X-ray and magnetic resonance imaging revealed massive right pleural effusion, ascites and a large subserosal uterine myoma. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. The pathology was consistent with a benign leiomyoma. The ascites and pleural effusion rapidly disappeared postoperatively. The serum interleukin-6 level was 3.9 pg/mL before surgery and declined to 1.6 pg/mL postoperatively. Previous published work has demonstrated that vascular endothelial growth factor and interleukin-6 may play a role in the pathogenesis of Meigs' syndrome and that vascular endothelial growth factor may contribute to the development of pseudo-Meigs' syndrome due to metastatic ovarian cancer. This is the first English-language study showing the possibility that interleukin-6 is relevant to the pathogenesis of pseudo-Meigs' syndrome caused by degenerating uterine leiomyoma.
authors.affiliation: Department of Obstetrics and Gynecology, Fuchu Hospital, Izumi, Osaka, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Oguma
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Yamasaki
authors.forename: Kentaro
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Dan
authors.initials: D
authors.lastname: Kinoshita
authors.forename: Tamae
authors.initials: T
authors.lastname: Mitsuhashi
authors.forename: Shoko
authors.initials: S
authors.lastname: Nakagawa
mesh_terms: D001201:Ascites / Q000209:etiology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003937:Diagnosis, Differential; D004417:Dyspnea / Q000209:etiology; D005260:Female; D006801:Humans; D007044:Hysterectomy; D015850:Interleukin-6 / Q000097:blood; D007889:Leiomyoma / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D008539:Meigs Syndrome / Q000175:diagnosis*; D008875:Middle Aged; D009215:Myometrium / Q000473:pathology; D010052:Ovariectomy; D016066:Pleural Effusion, Malignant / Q000209:etiology; D058994:Salpingectomy; D016896:Treatment Outcome; D015854:Up-Regulation; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6
keywords: cytokine; hydropic degeneration; interleukin-6; pseudo-Meigs' syndrome; uterine leiomyoma