title: [Expression and clinical significance of gastric dramatic down-related gene in gastric cancer and precancerous lesions].
abstract: OBJECTIVE
  To investigate the expression and clinical significance of gastric dramatic down-related gene (GDDR) in gastric cancer and precancerous lesion tissues.
  
  
  METHODS
  Immunohistochemical staining was performed to detect the expression of GDDR in 240 cases of gastric tissues, including 40 cases of normal gastric mucosa (NGM), 40 cases of chronic superficial gastritis (CSG), 40 cases of chronic atrophic gastritis (CAG), 40 cases of intestinal metaplasia (IM), 20 cases of mild dysplasia (MD), 20 cases of severe dysplasia (SD) and 40 cases of gastric cancer (GC).
  
  
  RESULTS
  The mean rank order of GDDR were 190.70, 182.70, 146.24, 104.40, 70.33, 47.20 and 40.20 in NGM, CSG, CAG, IM, MD, SD and GC, respectively. The expression of GDDR significantly decreased in CAG, IM, MD, SD and GC as compared with normal controls and CSG (P<0.01).
  
  
  CONCLUSIONS
  The gradually down-regulated expression of GDDR is an early molecular event in the development of gastric cancer. GDDR may play an important role in the early diagnosis of gastric cancer and may be utilized as a molecular diagnostic marker and a new target of anti-tumor molecular therapy in early stage of gastric cancer.
authors.affiliation: Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Zhanwei
authors.initials: Z
authors.lastname: Zhao
authors.forename: Cheng
authors.initials: C
authors.lastname: Fang
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Jianbo
authors.initials: J
authors.lastname: Shuang
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Hua
authors.forename: Jianjun
authors.initials: J
authors.lastname: DU
mesh_terms: D002352:Carrier Proteins / Q000032:analysis*; D055088:Early Detection of Cancer; D005753:Gastric Mucosa / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D011230:Precancerous Conditions / Q000737:chemistry* / Q000175:diagnosis; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000175:diagnosis
chemical_list: D002352:Carrier Proteins; C503073:GKN2 protein, human