title: Increased HIV-1 activity in anal high-grade squamous intraepithelial lesions compared with unaffected anal mucosa in men who have sex with men.
abstract: We studied 3 patients with focal intra-anal tissue high-grade squamous intraepithelial lesions (HSILs). All had increased human immunodeficiency virus type 1 (HIV-1) RNA and DNA in lesions compared with that in healthy mucosa. HIV-1 RNA and HIV-1 episomal DNA were indicative of ongoing viral replication, more so in anal HSILs.
authors.affiliation: Institute of Infection and Global Health/CIMI, University of Liverpool, United Kingdom.
authors.forename: Georgios
authors.initials: G
authors.lastname: Pollakis
authors.forename: Olivier
authors.initials: O
authors.lastname: Richel
authors.forename: Joost D
authors.initials: JD
authors.lastname: Vis
authors.forename: Jan M
authors.initials: JM
authors.lastname: Prins
authors.forename: William A
authors.initials: WA
authors.lastname: Paxton
authors.forename: Henry J C
authors.initials: HJ
authors.lastname: de Vries
mesh_terms: D001005:Anus Neoplasms / Q000150:complications* / Q000821:virology; D002278:Carcinoma in Situ / Q000150:complications* / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D018451:Homosexuality, Male; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology / Q000821:virology; D008297:Male; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012725:Sexual Behavior; D019562:Viral Load
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral
keywords: anal intraepithelial neoplasia; anal mucosa; human immunodeficiency virus type 1; human papilloma virus