title: Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities.
abstract: Four new stichoneurine-type alkaloids, stichoneurines F and G (1-2) and sessilistemonamines E and F (3-4), have been isolated from the root extracts of Stichoneuron caudatum. The structures and relative configurations of these alkaloids have been determined by spectroscopic methods and molecular modeling experiments. Compounds 1-4 were tested for their acetylcholinesterase (AChE) inhibitory activities against human AChE. Compound 3 showed significant inhibitory activity with an IC50 value of 9.1±0.15 μM.
authors.affiliation: School of Chemistry, University of Wollongong , Wollongong, New South Wales 2522, Australia.
authors.forename: Rosdayati A
authors.initials: RA
authors.lastname: Ramli
authors.forename: Wilford
authors.initials: W
authors.lastname: Lie
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Pyne
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008296:Malaysia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D041901:Stemonaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors