title: Colorectal cancer and self-reported tooth agenesis.
abstract: BACKGROUND
  Germline mutations in APC and AXIN2 are both associated with colon neoplasia as well as anomalous dental development. We tested the hypothesis that congenitally missing teeth may occur more commonly in individuals diagnosed with colorectal cancer than in individuals without this diagnosis.
  
  
  METHODS
  Via a survey conducted on 1636 individuals with colorectal cancer (CRC) and 2788 individuals with no colorectal cancer from the Colon Cancer Family Registry, self-reported information on congenitally missing teeth was collected. The frequency of missing teeth between cases and controls was compared using Pearson's chi-squared test or Fisher's exact test.
  
  
  RESULTS
  4.8% of cases and 5.7% of controls reported having at least one missing tooth (p = 0.20). When we stratified by recruitment site, gender, and mutation status where available, frequency of missing teeth was not statistically significantly different between cases and controls.
  
  
  CONCLUSIONS
  This study did not provide support for there being a general predisposition to missing teeth among a large cohort of CRC patients. The study neither addresses nor excludes the possibility, however, that individuals presenting with notable hypodontia/oligodontia might still have an increased risk for colorectal neoplasia.
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, 13400 East Shea Blvd,, Scottsdale, AZ 85259, USA. nlindor@mayo.edu.
authors.forename: Noralane M
authors.initials: NM
authors.lastname: Lindor
authors.forename: Aung Ko
authors.initials: AK
authors.lastname: Win
authors.forename: Steven
authors.initials: S
authors.lastname: Gallinger
authors.forename: Darshana
authors.initials: D
authors.lastname: Daftary
authors.forename: Stephen N
authors.initials: SN
authors.lastname: Thibodeau
authors.forename: Renato
authors.initials: R
authors.lastname: Silva
authors.forename: Ariadne
authors.initials: A
authors.lastname: Letra