title: Northward genetic penetration across the Himalayas viewed from Sherpa people.
abstract: The Himalayas have been suggested as a natural barrier for human migrations, especially the northward dispersals from the Indian Subcontinent to Tibetan Plateau. However, although the majority of Sherpa have a Tibeto-Burman origin, considerable genetic components from Indian Subcontinent have been observed in Sherpa people living in Tibet. The western Y chromosomal haplogroups R1a1a-M17, J-M304, and F*-M89 comprise almost 17% of Sherpa paternal gene pool. In the maternal side, M5c2, M21d, and U from the west also count up to 8% of Sherpa people. Those lineages with South Asian origin indicate that the Himalayas have been permeable to bidirectional gene flow.
authors.affiliation: a Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet , Ministry of Education, Tibet University for Nationalities , Xianyang , Shaanxi , China and.
authors.forename: Longli
authors.initials: L
authors.lastname: Kang
authors.affiliation: b Ministry of Education Key Laboratory of Contemporary Anthropology , School of Life Sciences, Fudan University , Shanghai , China.
authors.forename: Chuan-Chao
authors.initials: CC
authors.lastname: Wang
authors.affiliation: a Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet , Ministry of Education, Tibet University for Nationalities , Xianyang , Shaanxi , China and.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: b Ministry of Education Key Laboratory of Contemporary Anthropology , School of Life Sciences, Fudan University , Shanghai , China.
authors.forename: Dali
authors.initials: D
authors.lastname: Yao
authors.affiliation: b Ministry of Education Key Laboratory of Contemporary Anthropology , School of Life Sciences, Fudan University , Shanghai , China.
authors.forename: Li
authors.initials: L
authors.lastname: Jin
authors.affiliation: a Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet , Ministry of Education, Tibet University for Nationalities , Xianyang , Shaanxi , China and.|b Ministry of Education Key Laboratory of Contemporary Anthropology , School of Life Sciences, Fudan University , Shanghai , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D041322:Chromosomes, Human, Y; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D051456:Gene Flow; D005788:Gene Pool; D005828:Genetics, Population; D006239:Haplotypes; D063426:Human Migration; D006801:Humans; D007194:India; D008297:Male; D019683:Penetrance; D018609:Tibet
chemical_list: D004272:DNA, Mitochondrial
keywords: Himalayas; Sherpa; Y chromosome; mitochondrial DNA