title: [Risk factors of hemorrhagic transformation in different locations and its relation to clinical outcomes of patients with acute ischemic stroke following intravenous thrombolysis].
abstract: To investigate the risk factors of hemorrhagic transformation (HT) in different cerebral regions and to explore its relation to clinical outcomes of patients with acute ischemic stroke after intravenous thrombolysis therapy.
  
  
  
  The clinical, laboratory, and radiological data of 292 consecutive acute ischemic stroke patients undergoing intravenous thrombolysis therapy in Second Affiliated Hospital, Zhejiang University School of Medicine from June 2009 to May 2013 was retrospectively analyzed. Deep HT was defined as HT located in basal ganglia, internal capsule, external capsule and thalamus, otherwise the lesion was defined as non-deep HT. Patients were divided into 3 groups [Deep HT(n=47), non-deep HT(n=82), non HT(n=8)] and the differences in clinical and demographic characteristics were compared by using one-way analysis of variance and Ξ2-test. Multivariable logistic regression models were used to determine the independent risk factors of HT in different cerebral regions and clinical outcomes.
  
  
  
  Age, baseline National Institutes of Health Stroke Scale (NIHSS) score, baseline systolic blood pressure and the frequency of atrial fibrillation were different among three groups. Logistic regression analysis revealed that baseline NIHSS score (OR=1.126, 95%CI:1.063-1.193, P<0.001) and baseline systolic blood pressure (OR=0.982, 95%CI:0.967-0.998, P=0.020) were independent risk factors of deep HT. Multivariate analysis also found that deep HT was an independent predictor of functional outcome after thrombolysis (OR=0.291, 95%CI:0.133-0.640, P=0.002).
  
  
  
  Baseline NIHSS score and systolic blood pressure are predictors for deep hemorrhagic transformation, which indicates the poor functional outcome of patients with acute ischemic stroke following thrombolytic therapy.
authors.affiliation: Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.
authors.forename: Jin-ping
authors.initials: JP
authors.lastname: Wan
authors.affiliation: Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.
authors.forename: Ke-qin
authors.initials: KQ
authors.lastname: Liu
authors.affiliation: Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.
authors.forename: Xin
authors.initials: X
authors.lastname: Cai
authors.affiliation: Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.
authors.forename: Yi-ping
authors.initials: YP
authors.lastname: Lou
authors.affiliation: Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.
authors.forename: Zhi-cai
authors.initials: ZC
authors.lastname: Chen
authors.affiliation: Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.
authors.forename: Min
authors.initials: M
authors.lastname: Lou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D010959:Tissue Plasminogen Activator