title: Effect of growth hormone, glutamine, and enteral nutrition on intestinal adaptation in patients with short bowel syndrome.
abstract: OBJECTIVE
  In the management of short bowel syndrome, the benefits of treatment with growth hormone, glutamine, and enteral nutrition for intestinal adaptation is still controversial. The aim of the current study was to determine whether growth hormone, glutamine, and enteral nutrition had positive effect on intestinal adaptation.
  
  
  METHODS
  Twelve patients with short bowel syndrome (small-bowel remnant length, 59±9 cm; mean±SEM) received growth hormone (0.05 mg/kg/day), oral glutamine (30 g/day), plus enteral nutrition for 4 weeks. Intestinal absorptive capacity and biochemical parameters were investigated before treatment and after treatment. Body composition was determined by bioelectric impedance analysis.
  
  
  RESULTS
  All patients completed the treatment. Intestinal absorptive capacity and plasma levels of proteins were significantly improved after treatment. Body weight, lean body mass, total body water, and body cell mass also increased without any major adverse effects. At the 3-month follow-up, the nutritional status of patients was also well maintained, and there was no death during this period.
  
  
  CONCLUSIONS
  Four weeks of intestinal rehabilitation therapy significantly improved intestinal absorption if appropriate patient with short bowel syndrome was selected.
authors.forename: Mingxiao
authors.initials: M
authors.lastname: Guo
authors.forename: Yousheng
authors.initials: Y
authors.lastname: Li
authors.forename: Jieshou
authors.initials: J
authors.lastname: Li
mesh_terms: D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D001823:Body Composition; D001834:Body Water; D001835:Body Weight; D002648:Child; D004750:Enteral Nutrition; D005260:Female; D005973:Glutamine / Q000627:therapeutic use; D013006:Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D012778:Short Bowel Syndrome / Q000503:physiopathology* / Q000628:therapy*; D055815:Young Adult
chemical_list: D005973:Glutamine; D013006:Growth Hormone