title: Sonothrombolysis in acute middle cerebral artery stroke.
abstract: OBJECTIVE
  The objective of the following study is to determine the effect of continuous insonation using 2-MHz transcranial Doppler-ultrasound (TCD-US) on the recanalization rate and the short-term outcome in subjects with acute ischemic stroke due to middle cerebral artery (MCA) occlusion.
  
  
  METHODS
  A total of 42 patients with acute ischemic stroke due to MCA occlusion within 24 h were recruited and randomly allotted to two groups (21 patients in each group). Group 1 included patients who received 1 h continuous TCD-US for MCA and Group 2 included patients who did not receive 1 h continuous TCD-US. Patients in both groups were received MCA insonation and TCD study to measure mean flow velocity (MFV) in MCA one after the initial study at 20 and 60 min. All patients received aspirin (150-325 mg). The clinical course during hospital stay was assessed before and after 1 h of US insonation, at 24 h after symptom onset using the National Institutes of Health Stroke Scale.
  
  
  RESULTS
  Change in MFV after insonation for Group 1 in comparison to Group 2 at 3 time points was significantly high (P < 0.001).
  
  
  CONCLUSIONS
  Sonothrombolysis is a therapeutic option to improve the outcomes in patients with acute ischemic stroke due to MCA occlusion.
authors.forename: Amira Zaki
authors.initials: AZ
authors.lastname: Dwedar
authors.forename: Samia
authors.initials: S
authors.lastname: Ashour
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Haroun
authors.forename: Azza Abd
authors.initials: AA
authors.lastname: El Nasser
authors.forename: Ramez Reda
authors.initials: RR
authors.lastname: Moustafa
authors.affiliation: Department of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Mohamed Hamdy
authors.initials: MH
authors.lastname: Ibrahim
authors.forename: Ahmed
authors.initials: A
authors.lastname: Elsadek
mesh_terms: D000328:Adult; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage; D001783:Blood Flow Velocity / Q000502:physiology; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome; D017585:Ultrasonography, Doppler, Transcranial / Q000295:instrumentation / Q000379:methods*
chemical_list: D005343:Fibrinolytic Agents; D001241:Aspirin