title: Inhibition of MLL1 methyltransferase activity suppresses MLL cell growth.
abstract: MLL1 methyltransferase activity mediates MLL1-dependent transcription and MLL cell survival.
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D051788:Myeloid-Lymphoid Leukemia Protein / Q000037:antagonists & inhibitors*; D009842:Oligopeptides / Q000494:pharmacology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology; D055503:Protein Multimerization / Q000187:drug effects
chemical_list: C587684:MM-401; D009842:Oligopeptides; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase