title: LTP: GluN2B on the go.
abstract: LTP, the lasting increase in synaptic transmission following heightened activity, is viewed as the physiological basis of learning. In this issue of The EMBO Journal, Dupuis et al find that certain NMDARs diffuse away upon LTP. Antibodies against the NMDAR from patients with autoimmune synaptic encephalitis prevent this redistribution and LTP.
authors.affiliation: Department of Pharmacology, University of California, Davis, CA, USA.
authors.forename: Lucas
authors.initials: L
authors.lastname: Matt
authors.forename: Johannes W
authors.initials: JW
authors.lastname: Hell
mesh_terms: D000818:Animals; D009473:Neuronal Plasticity; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013569:Synapses / Q000502:physiology*
chemical_list: C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate