title: The comparison of histological results of experimentally created facial nerve defects repaired by 2 different anastomosis techniques: classic suture technique or tissue adhesives for nerve anastomosis?
abstract: OBJECTIVE
  The objective of this study was to compare the histological regeneration characteristics of nerve fibers at the anastomosis lines performed by classic suture technique or a tissue adhesive (N-butyl-2-cyanoacrylate).
  
  
  METHODS
  The control group consisted of 7 rabbits. The 21 rabbits were randomly divided into 3 groups based on the harvesting week. In the study group following preparation of facial nerve bilaterally, a 0.5-cm segment of facial dorsal buccal nerve was resected, and the defect was repaired with a nerve graft, which was harvested from sural nerve of the same side by 8-0 nylon suture technique and by application of N-butyl-2-cyanoacrylate on the other side.
  
  
  RESULTS
  Electron microscopic examination at consecutive second, fourth, and sixth days (corresponding to 4th, 8th, and 12th week in human subjects) revealed increased nerve degeneration findings in N-butyl-2-cyanoacrylate group when compared with microsuture repair technique.
  
  
  CONCLUSIONS
  We conclude that N-butyl-2-cyanoacrylate is not an appropriate material for nerve anastomosis.
authors.affiliation: From the *Department of Otolaryngology, Head and Neck Surgery, Bozok University Medical Faculty, Yozgat; †Medical Sciences Research and Application Center, Çukurova University, Adana; ‡Department of Otolaryngology, Head and Neck Surgery, Elazig Research Hospital, Elazig; §Department of Histology and Embryology, Çukurova University, Adana; ∥Department of Otolaryngology, Head and Neck Surgery, Sanliurfa Birecik Hospital, Sanliurfa, Turkey.
authors.forename: Zeliha Kapusuz
authors.initials: ZK
authors.lastname: Gencer
authors.forename: Mahmut
authors.initials: M
authors.lastname: Özkiriş
authors.forename: Levent
authors.initials: L
authors.lastname: Saydam
authors.forename: Y Kenan
authors.initials: YK
authors.lastname: Dağlioğlu
authors.forename: Öner
authors.initials: Ö
authors.lastname: Sakallioglu
authors.forename: Yurdun
authors.initials: Y
authors.lastname: Kuyucu
authors.forename: Sait
authors.initials: S
authors.lastname: Polat
authors.forename: Alper
authors.initials: A
authors.lastname: Kanmaz
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D004195:Disease Models, Animal; D004659:Enbucrilate / Q000627:therapeutic use*; D020220:Facial Nerve Injuries / Q000601:surgery*; D008297:Male; D009416:Nerve Regeneration / Q000502:physiology; D016067:Nerve Transfer / Q000379:methods*; D011817:Rabbits; D019651:Plastic Surgery Procedures / Q000379:methods*; D013497:Sural Nerve / Q000637:transplantation; D013536:Suture Techniques; D014014:Tissue Adhesives / Q000627:therapeutic use; D014945:Wound Healing / Q000502:physiology
chemical_list: D014014:Tissue Adhesives; D004659:Enbucrilate