title: Peptidomimetics via modifications of amino acids and peptide bonds.
abstract: Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in therapy. Self-structural organizations such as turns, helices, sheets and loops can be accessed by chemical modifications of amino acids or peptides. In-depth structural and conformational analysis and structure-activity relationships (SAR) offer a way to establish peptidomimetic libraries. Herein, we review recent developments in peptidomimetics that are formed via heteroatom replacement within the native amino acid backbone. Each sub-section describes structural features, utility and preparative methods.
authors.affiliation: Department of Chemistry, Faculty of Science, Anadolu University, 26470, Eskişehir, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Avan
authors.forename: C Dennis
authors.initials: CD
authors.lastname: Hall
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001671:Biochemistry / Q000379:methods*; D010455:Peptides / Q000737:chemistry*; D057786:Peptidomimetics / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D010455:Peptides; D057786:Peptidomimetics