title: Study of the correlation between growth hormone deficiency and serum leptin, adiponectin, and visfatin levels in adults.
abstract: We aimed to determine the significance and changes in leptin, adiponectin (ADP), and visfatin levels in adults with growth hormone deficiency (GHD). Forty adults (19 men, 21 women) who had been diagnosed with GHD comprised the observation group, while 36 healthy adults (18 men, 18 women) were used as the control group. Fasting venous blood was collected to detect leptin, ADP, and visfatin levels. There was no statistically significant difference (P > 0.05) between the GHD group and the control group in terms of gender ratio, age, and body mass index. The waist-to-hip ratio (0.894 ± 0.061 vs 0.830 ± 0.481), cholesterol (4.99 ± 1.046 vs 4.18 ± 0.683), triglyceride (1.97 ± 1.428 vs 1.08 ± 0.403), LDL (2.91 ± 0.980 vs 2.29 ± 0.540), leptin (3.00 ± 1.233 vs 1.89 ± 1.554), ADP (15.26 ± 6.449 vs 10.24 ± 7.608), and visfatin levels (10.42 ± 3.715 vs 5.87 ± 3.90) in the GHD group were significantly higher than those in the control group (all P < 0.05). The levels of growth hormone (1.68 ± 1.67 vs 15.53 ± 6.23), insulin-like growth factor-1 (IGF-1, 22.64 ± 16.41 vs 61.85 ± 28.48), IGF-binding protein-3 (4889 ± 2962 vs 6866 ± 3823), and dehydroepiandrosterone sulfate (1.466 ± 1.804 vs 6.000 ± 2.767) in the GHD group were significantly lower than those in the control group (all P < 0.05). Correlation analysis demonstrated that leptin level was positively correlated to ADP and visfatin in both the GHD and control groups and negatively correlated to IGF-1 (r = 0.332, P < 0.05). Logistic regression analysis demonstrated that leptin, ADP, and visfatin were independent risk factors for adults with GHD.
authors.affiliation: Golden Card Hospital, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Z-P
authors.initials: ZP
authors.lastname: Li
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: J
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: G-Y
authors.initials: GY
authors.lastname: Zhou
authors.affiliation: Golden Card Hospital, West China Hospital, Sichuan University, Chengdu, China lishuangqing201@yeah.net.
authors.forename: S-Q
authors.initials: SQ
authors.lastname: Li
authors.affiliation: Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Z-M
authors.initials: ZM
authors.lastname: An
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D016207:Cytokines / Q000097:blood*; D004393:Dwarfism, Pituitary / Q000097:blood* / Q000473:pathology; D005260:Female; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D052242:Adiponectin; D016207:Cytokines; D020738:Leptin; D014280:Triglycerides; D019382:Human Growth Hormone; D002784:Cholesterol; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human