title: Elevated levels of T-cell immune response cDNA 7 in patients with immune thrombocytopenia.
abstract: OBJECTIVE
  This study aimed to investigate the expression levels of T-cell immune response cDNA 7 (TIRC7) in immune thrombocytopenia (ITP) patients before and after high-dose dexamethasone (HD-DXM) treatment.
  
  
  METHODS
  Forty-four patients with ITP were enrolled and received dexamethasone (40 mg/day) for 4 consecutive days. Patients who had platelet counts more than 50 × 10(9)/l or less were defined as responders or non-responders, respectively. Quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to measure RNA level and plasma level of TIRC7, respectively.
  
  
  RESULTS
  TIRC7 levels (RNA and plasma level) were significantly higher in ITP than that in control (P < 0.0001). However, after treatment, TIRC7 levels were significantly decreased in responders (P < 0.0001) but not in non-responders (P > 0.05).
  
  
  CONCLUSIONS
  TIRC7 might be associated with the pathogenesis of ITP, and TIRC7 levels could be used as an indicator to evaluate patients' response to HD-DXM treatment.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Jian-lin
authors.initials: JL
authors.lastname: Qiao
authors.forename: Qing-yun
authors.initials: QY
authors.lastname: Wu
authors.forename: Jiang
authors.initials: J
authors.lastname: Cao
authors.forename: Ling-yu
authors.initials: LY
authors.lastname: Zeng
authors.forename: Zhen-yu
authors.initials: ZY
authors.lastname: Li
authors.forename: Kai-lin
authors.initials: KL
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012334:RNA, Neoplasm / Q000097:blood / Q000235:genetics; D013921:Thrombocytopenia / Q000097:blood* / Q000188:drug therapy* / Q000276:immunology; D025262:Vacuolar Proton-Translocating ATPases / Q000097:blood* / Q000235:genetics; D055815:Young Adult
chemical_list: D012334:RNA, Neoplasm; C472421:TCIRG1 protein, human; D003907:Dexamethasone; D025262:Vacuolar Proton-Translocating ATPases
keywords: Dexamethasone; Immune thrombocytopenia; T-cell immune response cDNA 7