title: [Utility of brain natriuretic peptide (BNP) to predict outcomes of patients undergoing elective cardiac surgery].
abstract: BACKGROUND
  We hypothesized that pre-operative BNP levels predict postoperative morbidity and mortality in patients undergoing non-emergent cardiac surgery.
  
  
  METHODS
  We retrospectively assessed patients who underwent non-emergent cardiac surgery at our institution regarding major morbidity (prolonged ventilation > 48 hours and prolonged ICU stay > 7 days), and all-cause mortality within 30 days. The cutoff value of BNP for prolonged ventilation was also evaluated.
  
  
  RESULTS
  A total of 62 patients with a mean age of 68.7 +/- 12.4 and preoperative BNP value of 391+/- 324 pg x ml(-1) were included. Risk factors for prolonged ventilation were high preoperative BNP and combined procedures. The risk factor for prolonged ICU stay was high preoperative BNP alone. All-cause mortality within 30 days were associated with high preoperative BNP and low intraoperative urine output. A preoperative BNP value (> 259 pg x ml(-1)) provided the optimal BNP cutoff point for prolonged ventilation, and predicted postoperative hemodynamic instability.
  
  
  CONCLUSIONS
  Preoperative BNP predicted postoperative morbidity and mortality.
authors.affiliation: Department of Anesthesiology, Kyorin University School of Medicine, Tokyo 181-8611.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Mikami
authors.affiliation: Department of Anesthesiology, Kyorin University School of Medicine, Tokyo 181-8611.
authors.forename: Harumasa
authors.initials: H
authors.lastname: Nakazawa
authors.affiliation: Department of Anesthesiology, Kyorin University School of Medicine, Tokyo 181-8611.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Moriyama
authors.affiliation: Department of Anesthesiology, Kyorin University School of Medicine, Tokyo 181-8611.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yorozu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D006348:Cardiac Surgical Procedures / Q000401:mortality; D017558:Elective Surgical Procedures / Q000401:mortality; D005260:Female; D005544:Forecasting; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011183:Postoperative Complications / Q000453:epidemiology / Q000401:mortality* / Q000503:physiopathology; D057234:Preoperative Period; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain