title: Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-induced inflammatory bowel disorder in albino rats.
abstract: BACKGROUND
  Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats.
  
  
  METHODS
  The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed.
  
  
  RESULTS
  The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups.
  
  
  CONCLUSIONS
  The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.
authors.affiliation: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.
authors.forename: Phani Krishna
authors.initials: PK
authors.lastname: Kondamudi
authors.affiliation: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.
authors.forename: Hemalatha
authors.initials: H
authors.lastname: Kovelamudi
authors.affiliation: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.
authors.forename: Geetha
authors.initials: G
authors.lastname: Mathew
authors.affiliation: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.
authors.forename: Pawan G
authors.initials: PG
authors.lastname: Nayak
authors.affiliation: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.
authors.forename: Mallikarjuna C
authors.initials: MC
authors.lastname: Rao
authors.affiliation: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.
authors.forename: Rekha R
authors.initials: RR
authors.lastname: Shenoy
mesh_terms: D019342:Acetic Acid / Q000633:toxicity*; D000818:Animals; D052117:Benzodioxoles / Q000494:pharmacology / Q000627:therapeutic use*; D003106:Colon / Q000187:drug effects* / Q000201:enzymology; D005260:Female; D015212:Inflammatory Bowel Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D009195:Peroxidase / Q000378:metabolism*; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D052117:Benzodioxoles; D010636:Phenols; C025583:sesamol; D009195:Peroxidase; D019342:Acetic Acid