title: Bovine mammary stem cells: new perspective for dairy science.
abstract: Mammary stem cells provide opportunities for the cyclic remodelling of the bovine mammary gland. Therefore, understanding the character and regulation of mammary stem cells is important for increasing animal health and productivity. The exciting possibility that stem cell expansion can influence milk production is currently being investigated by several researchers. In fact, appropriate regulation of mammary stem cells could hopefully benefit milk yield, persistency of lactation, dry period management and tissue repair. Accordingly, we and others have attempted to characterize and regulate the function of bovine mammary stem cells. However, research on mammary stem cells requires tissue biopsies, which represents a limitation for the management of animal welfare. Interestingly, different studies recently reported the identification of putative mammary stem cells in human breast milk. The possible identification of primitive cell types within cow's milk may provide a non-invasive source of relevant mammary cells for a wide range of applications. In this review, we have summarized the main achievements in this field for dairy cow science and described the interesting perspectives open to manipulate milk persistency during lactation and to cope with oxidative stress during the transition period by regulating mammary stem cells.
authors.affiliation: a Department of Veterinary Science , University of Turin , Grugliasco , TO , Italy.
authors.forename: E
authors.initials: E
authors.lastname: Martignani
authors.forename: D
authors.initials: D
authors.lastname: Cravero
authors.forename: S
authors.initials: S
authors.lastname: Miretti
authors.forename: P
authors.initials: P
authors.lastname: Accornero
authors.forename: M
authors.initials: M
authors.lastname: Baratta
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology* / Q000378:metabolism; D000818:Animals; D002417:Cattle / Q000502:physiology; D049109:Cell Proliferation; D003612:Dairying; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism; D005260:Female; D007774:Lactation; D008321:Mammary Glands, Animal / Q000166:cytology* / Q000187:drug effects; D008892:Milk / Q000378:metabolism
keywords: cow; dry period; mammary gland; milk; oxidative stress; precursors; stem cells