title: Genetic variations in the IGF-IGFR-IGFBP axis confer susceptibility to lung and esophageal cancer.
abstract: Recent evidence suggests that genetic variations in the insulin-like growth factor (IGF)-IGF receptor (IGFR)-IGF binding proteins (IGFBP) axis may impact an individual's susceptibility to lung and esophageal cancer, but individually published results are inconclusive. Our meta-analysis aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 15th, 2013. This meta-analysis was performed using the STATA 12.0 software. The crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for each study and then pooled using a random effect model. Twelve case-control studies were included with a total of 2686 lung cancer patients, 771 esophageal cancer patients, and 5918 healthy controls. Our meta-analysis indicated that genetic variations in the IGF-IGFR-IGFBP axis may be associated with increased risk of lung and esophageal cancer, especially among Asian populations. Further subgroup analysis by gene type indicated that common polymorphisms in the IGF1/2, IGF-1R, and IGFBP-3/5 genes may be the main determinants for lung cancer risk, while IGF-1, IGF-1R, and IGFBP-1 genetic polymorphisms may increase the risk of esophageal cancer. The current meta-analysis suggests that genetic variations in the IGF-IGFR-IGFBP axis confer susceptibility to lung and esophageal cancer, especially among Asian populations. Common polymorphisms in the IGF-IGFR-IGFBP axis may serve as useful biomarkers for predicting the risk of lung and esophageal cancer.
authors.affiliation: Department of Cardiothoracic Surgery, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou, China wz2h_hxp@126.com.
authors.forename: X P
authors.initials: XP
authors.lastname: Huang
authors.affiliation: Department of Cardiothoracic Surgery, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou, China.
authors.forename: W H
authors.initials: WH
authors.lastname: Zhou
authors.affiliation: Department of Cardiothoracic Surgery, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou, China.
authors.forename: Y F
authors.initials: YF
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D017594:Publication Bias; D017451:Receptors, Somatomedin / Q000235:genetics*; D012306:Risk; D013002:Somatomedins / Q000235:genetics*
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins; D017451:Receptors, Somatomedin; D013002:Somatomedins