title: Liposome and protein based stealth nanoparticles.
abstract: Liposomes and protein based nanoparticles were tuned with different polymers and glycolipids to improve stealth and thus decrease their clearance by macrophages. Liposomes were coated with polyethylene glycol (PEG) and brain-tissue-derived monosialoganglioside (GM1). Bovine serum albumin (BSA) nanoparticles were produced incorporating a PEGylated surfactant (PEG-surfactant). All obtained nanoparticles were monodisperse, with sizes ranging from 80 to 120 nm, with a zeta-potential close to zero. The presented stealth strategies lead to a decrease of internalization levels by macrophages. These surface modified nanoparticles could be used for production of new drug delivery nanosystems for systemic administration (e.g. intravenous application).
authors.forename: Eugénia
authors.initials: E
authors.lastname: Nogueira
authors.forename: Ana
authors.initials: A
authors.lastname: Loureiro
authors.forename: Patrícia
authors.initials: P
authors.lastname: Nogueira
authors.forename: Jaime
authors.initials: J
authors.lastname: Freitas
authors.forename: Catarina R
authors.initials: CR
authors.lastname: Almeida
authors.forename: Johan
authors.initials: J
authors.lastname: Härmark
authors.forename: Hans
authors.initials: H
authors.lastname: Hebert
authors.forename: Alexandra
authors.initials: A
authors.lastname: Moreira
authors.forename: Alexandre M
authors.initials: AM
authors.lastname: Carmo
authors.forename: Ana
authors.initials: A
authors.lastname: Preto
authors.forename: Andreia C
authors.initials: AC
authors.lastname: Gomes
authors.forename: Artur
authors.initials: A
authors.lastname: Cavaco-Pauloa
mesh_terms: D008081:Liposomes; D008854:Microscopy, Electron; D053758:Nanoparticles; D011506:Proteins / Q000737:chemistry*
chemical_list: D008081:Liposomes; D011506:Proteins