title: EKG pattern of Brugada syndrome and sudden infant death syndrome--is it time to review the diagnostic criteria? Case report and review of literature.
abstract: Brugada Syndrome (BrS) is a cardiac disorder characterized by incomplete right bundle-branch block and ST elevations in the anterior precordial leads especially V1 -V3 , associated with an increased risk for sudden cardiac death (SCD) in young adults. Our case describes a patient with family history of sudden infant death syndrome (SIDS) who presented with a Brugada pattern unmasked by severe hyperkalemia and diabetic ketoacidosis. Several studies have concluded there may be a genetic link among SIDS, SDC, and BrS resulting from mutations in cardiac ion channel-related genes. Recognizing SIDS as part of the diagnostic criteria for BrS would help us identifying a significant number of families susceptible to develop SCD (as well as SIDS).
authors.affiliation: Danbury Hospital, Internal Medicine, Danbury, Connecticut.
authors.forename: Emiliana
authors.initials: E
authors.lastname: Franco
authors.forename: Andre
authors.initials: A
authors.lastname: Dias
authors.forename: Daniele
authors.initials: D
authors.lastname: Teresa
authors.forename: Kathy
authors.initials: K
authors.lastname: Hebert
mesh_terms: D000138:Acidosis / Q000150:complications / Q000188:drug therapy; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D053840:Brugada Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D002125:Calcium Gluconate / Q000627:therapeutic use; D002254:Carbonates / Q000627:therapeutic use; D004562:Electrocardiography / Q000379:methods*; D006801:Humans; D006934:Hypercalcemia / Q000150:complications / Q000188:drug therapy; D006943:Hyperglycemia / Q000150:complications / Q000188:drug therapy; D007231:Infant, Newborn; D007662:Ketosis / Q000150:complications / Q000188:drug therapy; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D005996:Nitroglycerin / Q000627:therapeutic use; D013398:Sudden Infant Death; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002254:Carbonates; D014665:Vasodilator Agents; C005686:sodium carbonate; D005996:Nitroglycerin; D008790:Metoprolol; D001241:Aspirin; D002125:Calcium Gluconate
keywords: Electrophysiology-Brugada syndrome; clinical; clinical, electrophysiology-cardiac arrest/sudden death