title: Imported falciparum malaria among adults requiring intensive care: analysis of the literature.
abstract: BACKGROUND
  Malaria is the most important imported tropical disease. Infection with Plasmodium falciparum is responsible for most of the morbidity and mortality. There are differences in both the epidemiology of imported malaria and in the facilities available to treat travellers with severe malaria between different parts of the world. There are limited data to guide clinicians caring for adults with imported malaria in an intensive care unit (ICU). Available data from the English-speaking literature concerning such patients was reviewed.
  
  
  METHODS
  PubMed was searched for studies on adults with imported malaria treated in an ICU. Data were extracted on the epidemiology, management, rates of concomitant community-acquired bacterial infection and outcomes.
  
  
  RESULTS
  Thirteen studies were identified, which between them included 1,001 patients over more than 40 years. Forty-one per cent were born and often still resident in an endemic country and were assumed to have at least partial immunity to the disease. Acute kidney injury (AKI) (36%), acute respiratory distress syndrome (ARDS) (31%) and impaired consciousness (25%) were common. Hyperparasitaemia (more than 2%) was seen in 57%. Thirty-four per cent required mechanical ventilation and 22% required renal replacement therapy. Community-acquired bacterial co-infection was seen in 8%; 2% had gram-negative bacteraemia at admission. Overall the case fatality rate was 9%.
  
  
  CONCLUSIONS
  Many patients who require admission to ICU were originally from malaria-endemic countries and many did not have hyperparasitaemia. Gram-negative bacteraemia was uncommon among adults with severe malaria. The case fatality rate remains high; however, improvements in ICU care and increasing use of artemisinins may reduce this in the future.
authors.forename: Michael
authors.initials: M
authors.lastname: Marks
authors.forename: Margaret
authors.initials: M
authors.lastname: Armstrong
authors.forename: David
authors.initials: D
authors.lastname: Walker
authors.affiliation: The Hospital for Tropical Diseases, Mortimer Market Centre, Capper Street, London WC1E 6JB, UK. tom.doherty@uclh.nhs.uk.
authors.forename: Tom
authors.initials: T
authors.lastname: Doherty
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003422:Critical Care / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D014195:Travel; D016896:Treatment Outcome