title: Mobilization of CD133+ progenitor cells in patients with acute cerebral infarction.
abstract: Progenitor cells (PCs) contribute to the endogenous repair mechanism after ischemic events. Interleukin-8 (IL-8) as part of the acute inflammatory reaction may enhance PC mobilization. Also, statins are supposed to alter number and function of circulating PCs. We aimed to investigate PC mobilization after acute ischemic stroke as well as its association with inflammatory markers and statin therapy. Sixty-five patients with ischemic stroke were enrolled in the study. The number of CD133+ PCs was analyzed by flow cytometry. Blood samples were drawn within 24 hours after symptom onset and after 5 days. The number of CD133+ PCs increased significantly within 5 days (p<0.001). We found no correlation between CD133+ PCs and the serum levels of IL-8, IL-6, or C-reactive protein (CRP). Multivariate analysis revealed that preexisting statin therapy correlated independently with the increase of CD133+ PCs (p=0.001). This study showed a mobilization of CD133+ PCs in patients with acute cerebral infarction within 5 days after symptom onset. The early systemic inflammatory response did not seem to be a decisive factor in the mobilization of PCs. Preexisting statin therapy was associated with the increase in CD133+ PCs, suggesting a potentially beneficial effect of statin therapy in patients with stroke.
authors.affiliation: Department of Neurology, Klinikum Rechts der Isar, Technische Universitaet Muenchen, Muenchen, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Sepp
authors.affiliation: Department of Radiology, Klinikum Rechts der Isar, Technische Universitaet Muenchen, Muenchen, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Franz
authors.affiliation: Department of Neurology, Klinikum Rechts der Isar, Technische Universitaet Muenchen, Muenchen, Germany.
authors.forename: Natalie
authors.initials: N
authors.lastname: Triftshaeuser
authors.affiliation: Department of Cardiovascular Diseases, Deutsches Herzzentrum der Technischen Universitaet Muenchen, Muenchen, Germany.
authors.forename: Ilka
authors.initials: I
authors.lastname: Ott
authors.affiliation: Department of Neurology, Klinikum Rechts der Isar, Technische Universitaet Muenchen, Muenchen, Germany.
authors.forename: Lorena
authors.initials: L
authors.lastname: Esposito-Bauer
authors.affiliation: Department of Neurology, Klinikum Rechts der Isar, Technische Universitaet Muenchen, Muenchen, Germany.
authors.forename: Regina
authors.initials: R
authors.lastname: Feurer
authors.affiliation: Department of Neurology, Klinikum Rechts der Isar, Technische Universitaet Muenchen, Muenchen, Germany.
authors.forename: Christian L
authors.initials: CL
authors.lastname: Seifert
authors.affiliation: Institute for Clinical Chemistry and Pathobiochemistry, Klinikum Rechts der Isar, Technische Universitaet Muenchen, Muenchen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Thaler
authors.affiliation: Department of Neurology, Klinikum Rechts der Isar, Technische Universitaet Muenchen, Muenchen, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hemmer
authors.affiliation: Department of Neurology, Klinikum Rechts der Isar, Technische Universitaet Muenchen, Muenchen, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Poppert
mesh_terms: D000071916:AC133 Antigen; D000208:Acute Disease; D000328:Adult; D053687:Adult Stem Cells / Q000502:physiology*; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism*; D002544:Cerebral Infarction / Q000097:blood / Q000276:immunology / Q000473:pathology*; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010455:Peptides / Q000378:metabolism*; D010751:Phosphopyruvate Hydratase / Q000097:blood; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8; C000606023:PROM1 protein, human; D010455:Peptides; D010751:Phosphopyruvate Hydratase