title: [Rapid specific IgE assay (ImmunoCAP® RAPID) and skin prick test in the diagnosis of allergic disease].
abstract: BACKGROUND
  ImmunoCAP® Rapid is a rapid test kit to measure the allergen-specific IgE to the eight major inhalation allergen (cat, mite, orchard grass, ragweed, wormwood, dog, cockroach, Japan cedar).
  
  
  METHODS
  We performed ImmunoCAP® Rapid 83 patients with allergic disease (26 males, 57 females, median aged 43 years, 53 of asthma, 43 of allergic rhinitis) in our allergy center. ImmunoCAP® Rapid results were compared with those of skin prick test (SPT).
  
  
  RESULTS
  Although total positive allergens of SPT were higher than that of ImmunoCAP® Rapid (26.5% vs 22.5%, p<0.05), there was no significantly difference of each positive allergen between two tests. The rate of ImmunoCAP® Rapid to Japan cedar was almost equivalent to SPT in all patients (68.7% vs 55.4%, p=0.07). In contrast, the rate of ImmunoCAP® Rapid to Japan cedar was higher than SPT in patients with rhinitis (90.4% vs 71.4%, p<0.05). Efficiency between ImmunoCAP® Rapid and SPT was 86.4%, sensitivity was 66.9%, and specificity was 93.4%. The reactivity of ImmunoCAP® Rapid to allergens significantly correlated with sizes of SPT (erythema: r=0.645, urticaria: r=0.657).
  
  
  CONCLUSIONS
  Although identification rate in the screening ImmunoCAP® Rapid slightly inferior to SPT, this test system was useful for diagnosis of Japan cedar and mite.
authors.affiliation: Department of Respiratory Medicine, Saitama Medical University; Allergy Center, Saitama Medical University.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Komiyama
authors.affiliation: Department of Respiratory Medicine, Saitama Medical University; Allergy Center, Saitama Medical University.
authors.forename: Ai
authors.initials: A
authors.lastname: Masumoto
authors.affiliation: Department of Respiratory Medicine, Saitama Medical University; Allergy Center, Saitama Medical University.
authors.forename: Fuyumi
authors.initials: F
authors.lastname: Nishihara
authors.affiliation: Department of Respiratory Medicine, Saitama Medical University; Allergy Center, Saitama Medical University.
authors.forename: Takehito
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: Department of Respiratory Medicine, Saitama Medical University; Allergy Center, Saitama Medical University.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Soma
authors.affiliation: Department of Respiratory Medicine, Saitama Medical University.
authors.forename: Koichi
authors.initials: K
authors.lastname: Hagiwara
authors.affiliation: Department of Respiratory Medicine, Saitama Medical University.
authors.forename: Minoru
authors.initials: M
authors.lastname: Kanazawa
authors.affiliation: Department of Respiratory Medicine, Saitama Medical University; Allergy Center, Saitama Medical University.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nagata
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000175:diagnosis* / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002415:Cats; D032485:Cryptomeria / Q000276:immunology; D004285:Dogs; D000939:Epitopes; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology*; D007428:Intradermal Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology; D011852:Radioallergosorbent Test; D011933:Reagent Kits, Diagnostic; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis* / Q000276:immunology*; D055815:Young Adult
chemical_list: D000485:Allergens; D015415:Biomarkers; D000939:Epitopes; D011933:Reagent Kits, Diagnostic; D007073:Immunoglobulin E