title: Self-assembled WO3-x hierarchical nanostructures for photothermal therapy with a 915 nm laser rather than the common 980 nm laser.
abstract: Photothermal therapy (PTT) is limited by unsuitable photothermal agents and near-infrared (NIR) light. Herein, self-assembled PEGylated WO3-x hierarchical nanostructures, which could serve as excellent laser-cavity mirrors, were successfully prepared via a simple one-pot solvothermal route. The as-prepared WO3-x hierarchical nanostructures displayed strong near-infrared absorption. The absorption of pure water at 980 nm is 30 times higher than that at 915 nm, and the temperature of water only increased by 3.4 °C under the irradiation of a 915 nm laser with a power density of 1.0 W cm(-2) for 10 min, while the temperature of water increased as much as 15.1 °C for the 980 nm laser. With continuous excitation by 915 nm light, the photothermal conversion efficiency of these WO3-x hierarchical nanostructures was evaluated to be 28.1%. Thus, the WO3-x hierarchical nanostructures could serve as excellent laser-cavity mirrors of a 915 nm laser. The PTT study on cancer cells in vivo demonstrated that the WO3-x hierarchical nanostructures can generate enough heat for efficient photothermal therapy of cancer cells under the irradiation of a 915 nm laser with a power density of 1.2 W cm(-2) over a short period (5-10 min).
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Rujia
authors.initials: R
authors.lastname: Zou
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Bingjie
authors.initials: B
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: An
authors.forename: Fei
authors.initials: F
authors.lastname: Yin
authors.forename: Yingqi
authors.initials: Y
authors.lastname: Hua
authors.forename: Junqing
authors.initials: J
authors.lastname: Hu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D007834:Lasers; D051379:Mice; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D010087:Oxides / Q000737:chemistry / Q000627:therapeutic use*; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D013696:Temperature; D014414:Tungsten / Q000737:chemistry / Q000627:therapeutic use*; D015032:Zinc / Q000737:chemistry
chemical_list: D010087:Oxides; D011092:Polyethylene Glycols; C511604:tungsten oxide; D015032:Zinc; D014414:Tungsten