title: Ligand-controlled asymmetric arylation of aliphatic α-amino anion equivalents.
abstract: A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkylbiaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of α-branched benzylamines.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhu
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D007097:Imines / Q000737:chemistry*; D008024:Ligands; D009844:Oligosaccharides / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D007097:Imines; D008024:Ligands; D009844:Oligosaccharides; C445400:9-Aminofluorene; D010165:Palladium