title: [Rational pharmacotherapy of the pathologically changed immune system of nasal mucosa in patients presenting with allergic rhinitis].
abstract: The objective of the present study was to analyse modern concepts of pathogenesis od local immune changes in nasal mucosa associated with allergic rhinitis (AR)and the currently available methods for rational pharmacotherapy of this condition. The factors of local congenital amd adaptive immunity inherent in nasal mucosa are considered in conjunction with the changes of immune characteristics in the patient presenting with the allergic rhinitis. It is concluded based on the literature data that the local cytokine profile has the highest informative value for the description of the inflammatory process in nasal mucosa. The author undertakes the comparative assessment of the pharmaceutical products available for the rational treatment of allergic rhinitis and related mucosal pathology by the correction of disturbed local immunity. Special attention is given to the application of the glucocorticoids (including topical ones), antihistamine preparations, and immunomodulators, such as cycloferon. It is concluded that the use of cycloferon for local pharmacotherapy makes it possible to maximally enhance the immune system response and thereby improve the results of the specific treatment.
authors.forename: N S
authors.initials: NS
authors.lastname: Tataurshchikova
mesh_terms: D056704:Adaptive Immunity; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D009297:Nasal Mucosa / Q000276:immunology* / Q000473:pathology*; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy / Q000276:immunology / Q000473:pathology
chemical_list: D018926:Anti-Allergic Agents; D005938:Glucocorticoids; D006634:Histamine H1 Antagonists