title: Arylestarase and oxidative stress in operating room personnel.
abstract: BACKGROUND
  Long-term occupational exposure to trace concentrations of volatile anesthetics is known to have adverse effects on the health of exposed personnel.
  
  
  OBJECTIVE
  We investigated paraoxonase-1 (PON1) and arylesterase (ARE), as well as antioxidant status (TAS) and total oxidant status (TOS) levels in anesthesia personnel (AP) who were chronically exposed to inhalation anesthetics, and compared them with levels in a control group.
  
  
  METHODS
  We designed a comparative prospective study with 50 female subjects. The first cohort included 25 full-time female workers in operating rooms in two locations in the Antalya Education and Research Hospital in Antalya, Turkey. The control group was comprised of 25 female individuals working in the same hospitals without any work-related exposure to hazardous agents.
  
  
  RESULTS
  Serum ARE activity and TAS levels were significantly reduced (p = 0.04 and p < 0.0001, respectively), whereas TOS and OSI levels were found to be significantly higher (p = 0.01 and p < 0.0001, respectively) in AP. However, there were no significant differences in PON1 activity, PON1/HDL-C, ARE/HDL-C, and PON1/ARE (p = 0.30, p = 0.5, p = 0.1 and p = 0.7, respectively) when the two groups were contrasted.
  
  
  CONCLUSIONS
  According to the results of this study, depending on the putative role of PON/ARE in oxidant stress-related diseases, particularly atherosclerosis and cancer, AP might be considered a risk group for the development of atherosclerosis and many other diseases.
authors.affiliation: Anesthesia Clinic of the Antalya Education and Research Hospital of the Ministry of Health, Antalya, Turkey.
authors.forename: Neset
authors.initials: N
authors.lastname: Cerit
authors.forename: Asuman Arslan
authors.initials: AA
authors.lastname: Onuk
authors.forename: Hamit Yasar
authors.initials: HY
authors.lastname: Ellidag
authors.forename: Esin
authors.initials: E
authors.lastname: Eren
authors.forename: Nurullah
authors.initials: N
authors.lastname: Bulbuller
authors.forename: Necat
authors.initials: N
authors.lastname: Yilmaz
mesh_terms: D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D006282:Health Personnel; D006801:Humans; D016273:Occupational Exposure; D009873:Operating Rooms; D018384:Oxidative Stress; D011446:Prospective Studies
chemical_list: D018685:Anesthetics, Inhalation; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase