title: [Why, when and how to monitor new oral anticoagulants].
abstract: Several direct oral anticoagulants (DOACs) are now widely used in the prevention and treatment of thromboembolic events. Unlike vitamin K antagonists, DOACs exhibit predictable pharmacokinetics and pharmacodynamics. DOACs are to be administered at fixed doses without routine coagulation monitoring. However, in some patient populations or specific clinical circumstances, measurement of drug exposure may be useful, such as in suspected overdose, in patients with a haemorrhagic or thromboembolic event during treatment with an anticoagulant, in those with acute renal failure, or in patients who require urgent surgery. This article provides practical guidance on laboratory testing of DOACs in routine practice and summarizes the influence of DOACs on commonly used coagulation assays.
authors.forename: Anne
authors.initials: A
authors.lastname: Tamigniau
authors.forename: Jonathan
authors.initials: J
authors.lastname: Douxfils
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Nicolas
authors.forename: Bérangère
authors.initials: B
authors.lastname: Devalet
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Larock
authors.forename: Anne
authors.initials: A
authors.lastname: Spinewine
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Dincq
authors.forename: Sarah
authors.initials: S
authors.lastname: Lessire
authors.forename: Maximilien
authors.initials: M
authors.lastname: Gourdin
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Watelet
authors.forename: Valerie
authors.initials: V
authors.lastname: Mathieux
authors.forename: Christian
authors.initials: C
authors.lastname: Chatelain
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Dogné
authors.forename: Bernard
authors.initials: B
authors.lastname: Chatelain
authors.forename: François
authors.initials: F
authors.lastname: Mullier
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000494:pharmacology*; D001780:Blood Coagulation Tests; D016903:Drug Monitoring; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications
chemical_list: D000925:Anticoagulants