title: Prediction of preeclampsia by placental protein 13 and background risk factors and its prevention by aspirin.
abstract: OBJECTIVE
  Evaluation of placental protein 13 (PP13) and risk factors (RFs) as markers for predicting preeclampsia (PE) and use of aspirin for PE prevention.
  
  
  METHODS
  First-trimester pregnancy screening was based on having PP13 level ≤0.4 multiple of the median (MoM) and/or at least one major risk factor (RF) for PE. Management was by routine care or combined with daily treatment with 75 mg aspirin between 14 and 35 weeks of gestation.
  
  
  RESULTS
  Of 820 deliveries, 63 women developed PE (7.7%). Median PP13 levels was 0.2MoM in the PE group compared with 0.83MoM among unaffected and 1.0MoM in unaffected not treated with aspirin (P<0.0001). Low PP13 was a better predictor for PE versus major RFs, particularly for young nuliparous. Combining low PP13 with RFs increased prediction accuracy. Mean arterial pressure (not included in the initial prediction), could add to prediction accuracy when combined with low PP13 and RFs. PE prevention by aspirin was most effective when the risk was determined by low PP13 alone, less effective for combining low PP13 with RFs, and ineffective when determined by RFs alone.
  
  
  CONCLUSIONS
  When PE risk is determined by low first trimester PP13 or by combined low PP13 and RFs, prevention with aspirin is warranted.
authors.forename: Hamutal
authors.initials: H
authors.lastname: Meiri
authors.forename: Marei
authors.initials: M
authors.lastname: Sammar
authors.forename: Ayelet
authors.initials: A
authors.lastname: Herzog
authors.forename: Yael-Inna
authors.initials: YI
authors.lastname: Grimpel
authors.forename: Galina
authors.initials: G
authors.lastname: Fihaman
authors.forename: Aliza
authors.initials: A
authors.lastname: Cohen
authors.forename: Vered
authors.initials: V
authors.lastname: Kivity
authors.forename: Adi
authors.initials: A
authors.lastname: Sharabi-Nov
authors.forename: Ron
authors.initials: R
authors.lastname: Gonen
mesh_terms: D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D005260:Female; D037161:Galectins / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology* / Q000517:prevention & control; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D037161:Galectins; C038195:LGALS13 protein, human; D011257:Pregnancy Proteins; D001241:Aspirin