title: Phototoxic dermatoses in pediatric BMT patients receiving voriconazole.
abstract: We investigated the incidence of phototoxic skin reactions in pediatric BMT recipients treated with voriconazole. Nine out of 40 patients (22.5%), all Caucasian, developed skin lesions in sun-exposed distributions. Dermatologic findings included sunburn-like erythema, pseudo-porphyria, linear papulovesicular lesions, severe erosive cheilitis, dermatoheliosis and lentigines. Patients were treated with sun avoidance, high-potency sunscreens, and topical steroids with significant improvement in all cases. Prolonged voriconazole use requires close monitoring for chronic skin toxicities. Long-term risks including the risk of skin cancer need to be investigated.
authors.affiliation: Division of Blood and Marrow Transplantation and Cellular Therapies, Children's Hospital of Pittsburgh of UPMC, Pennsylvania; Departments of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Goyal
authors.forename: Robin P
authors.initials: RP
authors.lastname: Gehris
authors.forename: Denise
authors.initials: D
authors.lastname: Howrie
authors.forename: Kayla M
authors.initials: KM
authors.lastname: Cogley
authors.forename: Randy M
authors.initials: RM
authors.lastname: Windreich
authors.forename: Raman
authors.initials: R
authors.lastname: Venkataramanan
mesh_terms: D064591:Allografts; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D011743:Pyrimidines / Q000008:administration & dosage / Q000009:adverse effects*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000517:prevention & control; D013472:Sunlight / Q000009:adverse effects*; D013473:Sunscreening Agents / Q000008:administration & dosage; D014230:Triazoles / Q000008:administration & dosage / Q000009:adverse effects*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D013473:Sunscreening Agents; D014230:Triazoles; D065819:Voriconazole
keywords: allogeneic BMT; phototoxicity; voriconazole