title: Remote activation of the nucleophilicity of isatin.
abstract: The concept of the remote activation of reactivity was first applied in asymmetric organocatalysis. An isatin 3-phenylimine derivative acts as a donor in the thiourea catalyzed asymmetric addition to unsaturated 1,4-ketoesters, affording aza-Michael adducts in high enantiomeric purity and yield.
authors.affiliation: Department of Chemistry, Tallinn University of Technology , Akadeemia tee 15, 12618 Tallinn, Estonia.
authors.forename: Sergei
authors.initials: S
authors.lastname: Žari
authors.forename: Marina
authors.initials: M
authors.lastname: Kudrjashova
authors.forename: Tõnis
authors.initials: T
authors.lastname: Pehk
authors.forename: Margus
authors.initials: M
authors.lastname: Lopp
authors.forename: Tõnis
authors.initials: T
authors.lastname: Kanger
mesh_terms: D002384:Catalysis; D004952:Esters; D007097:Imines / Q000737:chemistry; D007510:Isatin / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry
chemical_list: D004952:Esters; D007097:Imines; D007510:Isatin; D013890:Thiourea