title: Endocrine disruptome--an open source prediction tool for assessing endocrine disruption potential through nuclear receptor binding.
abstract: Predicting the endocrine disruption potential of compounds is a daunting but essential task. Here we report a new tool for this purpose that we have termed Endocrine Disruptome. It is a free and simple-to-use Web service that runs on an open source platform called Docking interface for Target Systems (DoTS). The molecular docking is handled via AutoDock Vina. Compounds are docked to 18 integrated and well-validated crystal structures of 14 different human nuclear receptors: androgen receptor; estrogen receptors α and β; glucocorticoid receptor; liver X receptors α and β; mineralocorticoid receptor; peroxisome proliferator activated receptors α, β/δ, and γ; progesterone receptor; retinoid X receptor α; and thyroid receptors α and β. Endocrine Disruptome is free of charge and available at http://endocrinedisruptome.ki.si.
authors.affiliation: Faculty of Pharmacy, University of Ljubljana , Aškerčeva 7, 1000 Ljubljana, Slovenia.
authors.forename: Katra
authors.initials: K
authors.lastname: Kolšek
authors.forename: Janez
authors.initials: J
authors.lastname: Mavri
authors.forename: Marija
authors.initials: M
authors.lastname: Sollner Dolenc
authors.forename: Stanislav
authors.initials: S
authors.lastname: Gobec
authors.forename: Samo
authors.initials: S
authors.lastname: Turk
mesh_terms: D052244:Endocrine Disruptors / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D062105:Molecular Docking Simulation; D011485:Protein Binding; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D014584:User-Computer Interface
chemical_list: D052244:Endocrine Disruptors; D018160:Receptors, Cytoplasmic and Nuclear