title: MTHFR C677T variant reduces risk of sporadic Parkinson's disease in ethnic Chinese.
abstract: BACKGROUND
  Genetic variability of methylenetetrahydrofolate reductase (MTHFR) may be associated with Parkinson's disease (PD). Its role in ethnic Chinese population is still unclear. Our study aimed to investigate whether MTHFR C677T variation was linked to PD risk in a Han Chinese population from mainland China.
  
  
  METHODS
  To investigate the association with the risk of PD, we analyzed the single-nucleotide polymorphism C677T in MTHFR gene using a case-control methodology. A total of 1482 subjects included 765 patients with idiopathic PD, and 717 age- and sex-matched controls were recruited in this study.
  
  
  RESULTS
  The T allele of MTHFR C677T was associated with a decreased risk of PD (OR = 0.80, 95% CI: 0.688-0.926, P = 0.003). Patients with CT + TT genotypes have a decreased risk of PD compared with those with CC genotypes (OR = 0.66, 95%CI: 0.532-0.813, P = 0.000). CT + TT subjects cannot be differentiated from CC subjects based on their clinical features.
  
  
  CONCLUSIONS
  We showed that the C677T polymorphism in MTHFR gene was associated with decreased PD susceptibility in a Han Chinese population from mainland China. Efforts to fully elucidate the pathophysiologic role of the variant in PD should be necessary.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Liao
authors.forename: N N
authors.initials: NN
authors.lastname: Li
authors.forename: X Y
authors.initials: XY
authors.lastname: Mao
authors.forename: X L
authors.initials: XL
authors.lastname: Chang
authors.forename: D M
authors.initials: DM
authors.lastname: Zhao
authors.forename: J H
authors.initials: JH
authors.lastname: Zhang
authors.forename: W J
authors.initials: WJ
authors.lastname: Yu
authors.forename: E K
authors.initials: EK
authors.lastname: Tan
authors.forename: R
authors.initials: R
authors.lastname: Peng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: MTHFR C677T; Parkinson's disease; SNP