title: An oxidative amidation and heterocyclization approach for the synthesis of β-carbolines and dihydroeudistomin Y.
abstract: A novel synthetic methodology has been developed for the synthesis of dihydro-β-carboline derivatives employing oxidative amidation-Bischler-Napieralski reaction conditions using tryptamine and 2,2-dibromo-1-phenylethanone as key starting materials. A number of dihydro-β-carboline derivatives have been synthesized in moderate to good yields using this methodology. Attempts were made towards the conversion of these dihydro-β-carbolines to naturally occurring eudistomin alkaloids.
authors.affiliation: Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad - 500049, India ; Department of Chemistry, College of Engineering, JNTUH, Kukatpally, Hyderabad - 500085, India.
authors.forename: Suresh Babu
authors.initials: SB
authors.lastname: Meruva
authors.affiliation: Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad - 500049, India.
authors.forename: Akula
authors.initials: A
authors.lastname: Raghunadh
authors.affiliation: Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad - 500049, India.
authors.forename: Raghavendra Rao
authors.initials: RR
authors.lastname: Kamaraju
authors.affiliation: Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad - 500049, India.
authors.forename: U K Syam
authors.initials: UK
authors.lastname: Kumar
authors.affiliation: Department of Chemistry, College of Engineering, JNTUH, Kukatpally, Hyderabad - 500085, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Dubey
keywords: Bischler–Napieralski reaction; dihydro-eudistomin; dihydro-β-carboline derivatives; eudistomin; keto amide; oxidative amidation