title: Human papillomavirus (HPV) deregulation of Toll-like receptor 9.
abstract: Persistent infection by high-risk human papillomavirus (HPV) is associated with cervical carcinoma. Blocking innate immune responses in the cervix is critical for the establishment of persistent infections. Here, we discuss how HPV-16-encoded factors suppress the activity of Toll-like receptor 9, which plays a major role in innate antiviral immune responses.
authors.affiliation: CIRI, Oncoviruses and Innate Immunity; INSERM U1111; Ecole Normale Supérieure; Université de Lyon; CNRS-UMR5308; Hospices Civils de Lyon; Lyon, France.
authors.forename: Uzma
authors.initials: U
authors.lastname: Hasan
keywords: E7; HPV16; TLR9; immunosuppression