title: Lawsonia inermis - an alternative treatment for hyperthyroidism?
abstract: OBJECTIVE
  The goal of our study was to determine the effects of Lawsonia inermis (L. inermis) in mice, in which hyperthyroidism had been caused by thyroid stimulant hormone (TSH).
  
  
  METHODS
  The first phase of the study aimed to detect the effects of L. inermis on the amount of ionized hydrogen (pH) in cells. For this aim, the effect of L. inermis on pH levels in the liver tissues of mice, in whom Escherichia coli (E. coli) had caused peritonitis, was examined. In the second phase of the study, the effect of L. inermis on the serum T4 levels in the 24th and 48th hour in mice, whose thyroid cells showed an increased activity by TSH was measured.
  
  
  RESULTS
  In the first phase, in mice, in whom E.coli had caused peritonitis, the pH in the liver tissue of the group that had been given L. inermis was found to be significantly alkaline (p<0.05). In the second phase, in mice, in whom TSH had caused hyperthyroidism, it was noted that serum total T4 levels were significantly lower than in the group that had been given L. inermis in the 48th hour (p<0.05).
  
  
  CONCLUSIONS
  In our study, we detected that L. inermis significantly decreased serum total T4 levels in the 48th hour in mice in whom TSH had caused hyperthyroidism. These results suggest that L. inermis can be used as an alternative treatment for the Graves' disease (Tab. 2, Fig. 1, Ref. 34).
authors.forename: E
authors.initials: E
authors.lastname: Zumrutdal
authors.forename: F
authors.initials: F
authors.lastname: Karateke
authors.forename: K
authors.initials: K
authors.lastname: Daglioglu
authors.forename: M
authors.initials: M
authors.lastname: Gulkaya
authors.forename: O
authors.initials: O
authors.lastname: Colak
authors.forename: F
authors.initials: F
authors.lastname: Koksal
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D006980:Hyperthyroidism / Q000188:drug therapy*; D031564:Lawsonia Plant; D051379:Mice; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000627:therapeutic use*; D013974:Thyroxine / Q000097:blood / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts; D013974:Thyroxine