title: Prevalence of mild cognitive impairment in an urban community in China: a cross-sectional analysis of the Shanghai Aging Study.
abstract: BACKGROUND
  Substantial variations in the prevalence of mild cognitive impairment (MCI) have been reported, although mostly in Western countries. Less is known about MCI in the Chinese population.
  
  
  METHODS
  We clinically and neuropsychologically evaluated 3141 community residents ≥60 years of age. Diagnoses of MCI and its subtypes were made using standard criteria via consensus diagnosis.
  
  
  RESULTS
  Among 2985 nondemented individuals, 601 were diagnosed with MCI, resulting in a prevalence of 20.1% for total MCI, 13.2% for amnestic MCI (aMCI), and 7.0% for non-amnestic MCI (naMCI). The proportions of MCI subtypes were: aMCI single domain (SD), 38.9%; aMCI multiple domains (MD), 26.5%; naMCI-SD, 25.0%; and naMCI-MD, 9.6%. The prevalence of aMCI-MD increased rapidly with age in women APOE ε4 carriers (from 60 to 69 years to ≥80 years, 3.1%-33.3%, P < .001).
  
  
  CONCLUSIONS
  Our findings suggest that 20% of Chinese elderly are affected by MCI. Prospective studies in China are needed to examine progression to dementia and related risk factors.
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Ding
authors.initials: D
authors.lastname: Ding
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Qianhua
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Qihao
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Haijiao
authors.initials: H
authors.lastname: Meng
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Health Statistics, School of Public Health, Fudan University, Shanghai, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: Mortimer
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.
authors.forename: Amy R
authors.initials: AR
authors.lastname: Borenstein
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: profzhong@sina.com.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D060825:Cognitive Dysfunction / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015995:Prevalence; D014505:Urban Population
keywords: Aging; Cross-sectional; Mild cognitive impairment; Population-based; Prevalence