title: A new multifunctional Schiff base as a fluorescence sensor for Al³⁺ and a colorimetric sensor for CN⁻ in aqueous media: an application to bioimaging.
abstract: A multifunctional fluorescent and colorimetric receptor 1 ((E)-N'-((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)benzohydrazide) for the detection of both Al(3+) and CN(-) in aqueous solution has been developed. Receptor 1 exhibited an excellent selective fluorescence response toward Al(3+). The sensitivity of the fluorescent based assay (0.193 μM) for Al(3+) is far below the limit in the World Health Organization (WHO) guidelines for drinking water (7.41 μM). In addition, receptor 1 showed an excellent detection ability in a wide pH range of 4-10 and also in living cells. Moreover, receptor 1 showed a highly selective colorimetric response to CN(-) by changing its color from colorless to yellow immediately without any interference from other anions.
authors.affiliation: Department of Fine Chemistry and Department of Interdisciplinary Bio IT Materials, Seoul National University of Science and Technology, Seoul 139-743, Korea. chealkim@seoultech.ac.kr.
authors.forename: Seul Ah
authors.initials: SA
authors.lastname: Lee
authors.forename: Ga Rim
authors.initials: GR
authors.lastname: You
authors.forename: Ye Won
authors.initials: YW
authors.lastname: Choi
authors.forename: Hyun Yong
authors.initials: HY
authors.lastname: Jo
authors.forename: Ah Ram
authors.initials: AR
authors.lastname: Kim
authors.forename: Insup
authors.initials: I
authors.lastname: Noh
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Youngmee
authors.initials: Y
authors.lastname: Kim
authors.forename: Cheal
authors.initials: C
authors.lastname: Kim
mesh_terms: D000535:Aluminum / Q000032:analysis*; D002478:Cells, Cultured; D003124:Colorimetry / Q000379:methods; D018360:Crystallography, X-Ray; D003486:Cyanides / Q000032:analysis*; D005347:Fibroblasts / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D012545:Schiff Bases / Q000737:chemistry; D014867:Water / Q000032:analysis*
chemical_list: D003486:Cyanides; D005456:Fluorescent Dyes; D012545:Schiff Bases; D014867:Water; D000535:Aluminum