title: Uterine tumors resembling ovarian sex cord tumors (UTROSCT). Report of a case with lymph node metastasis.
abstract: Uterine tumors resembling ovarian sex cord tumors (UTROSCT) have an uncertain histogenesis. Although generally considered to be benign, they metastasize in some cases. We report the case of a 53-year-old woman who presented with vaginal bleeding. Clinical examination revealed a tumor sized 1.5 cm in diameter localized in the subendometrial region of the uterine wall. Histologically, the tumor consisted of epithelioid oval cells arranged in solid nests, trabeculae and ribbons. Immunohistochemically, approximately 1% of tumor cells expressed strong desmin positivity, calponin in 10% of cells, WT1 in 80% cells, and Ki-67 was positive in about 5 % of tumor cells. All the other immunohistochemical reactions applied including anti-cytokeratin antibodies were negative. The RT-PCR method for identification of the JAZF1-JJAZ1 fusion transcript was negative. In one lymph node in the right iliac artery region, a metastasis of UTROSCT was found. This finding adds to the previously reported UTROSCT cases with metastatic spread.
  
  
  BACKGROUND
  uterine tumors resembling ovarian sex cord tumors - UTROSCT - metastasis - lymph node.
authors.forename: Jirka
authors.initials: J
authors.lastname: Mačák
authors.forename: Pavel
authors.initials: P
authors.lastname: Dundr
authors.forename: Jana
authors.initials: J
authors.lastname: Dvořáčková
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Klát
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D008875:Middle Aged; D018312:Sex Cord-Gonadal Stromal Tumors / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor