title: Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases.
abstract: Two promising uncharged reactivators for inhibited human BChE and AChE have been described. These compounds show an ability to reactivate VX-inhibited BChE largely superior to those of known pyridinium aldoximes. Moreover, these oximes also exhibit a good ability to reactivate VX-, tabun- and paraoxon-inhibited human AChE.
authors.affiliation: Normandie Univ; COBRA, UMR 6014 & FR 3038; Univ Rouen; INSA Rouen; CNRS, 1 Rue Tesnières, 76821 Mont-Saint-Aignan Cedex, France. pierre-yves.renard@univ-rouen.fr ludovic.jean@univ-rouen.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Renou
authors.forename: Mélanie
authors.initials: M
authors.lastname: Loiodice
authors.forename: Mélanie
authors.initials: M
authors.lastname: Arboléas
authors.forename: Rachid
authors.initials: R
authors.lastname: Baati
authors.forename: Ludovic
authors.initials: L
authors.lastname: Jean
authors.forename: Florian
authors.initials: F
authors.lastname: Nachon
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Renard
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D002091:Butyrylcholinesterase / Q000378:metabolism*; D002243:Carbolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010766:Phosphorylation / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D002243:Carbolines; D002800:Cholinesterase Inhibitors; D010091:Oximes; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase