title: Role of the MIR146A polymorphism in the origin and progression of oral squamous cell carcinoma.
abstract: Gene expression and cell behavior are regulated by several factors, including small non-coding RNAs. MicroRNAs affecting cell growth, differentiation, and apoptosis are thought to play an important role in tumorigenesis. The levels of miR-146 appear to be associated with cancer development and progression, including that of oral squamous cell carcinoma. The aim of this investigation was to ascertain whether the single nucleotide polymorphism, rs2910164, mapping in the MIR146A gene, has a role in oral squamous cell carcinoma progression. A genetic association study was performed with a sample set of 346 oral squamous cell carcinomas collected in Italy. Our data indicate that the rs2910164 polymorphism is not associated with tumor development. However, a slight increase in the frequency of the variant allele was observed in Stage II tumors. Further investigations are needed to verify a possible role of the variant allele or rs2910164 in oral squamous cell carcinoma progression.
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Palmieri
authors.forename: Francesco
authors.initials: F
authors.lastname: Carinci
authors.forename: Marcella
authors.initials: M
authors.lastname: Martinelli
authors.forename: Furio
authors.initials: F
authors.lastname: Pezzetti
authors.forename: Ambra
authors.initials: A
authors.lastname: Girardi
authors.forename: Francesca
authors.initials: F
authors.lastname: Cura
authors.forename: Corrado
authors.initials: C
authors.lastname: Rubini
authors.forename: Luca
authors.initials: L
authors.lastname: Scapoli
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D002874:Chromosome Mapping; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D009062:Mouth Neoplasms / Q000235:genetics*; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs
keywords: marker; microRNA; oral squamous cell carcinoma; single nucleotide polymorphism; tumor progression