title: Refractory sickle cell leg ulcer: is heparan sulphate a new hope?
abstract: Patients with sickle cell disease are known to have recurrent lower extremity ulcers that have a high pain score and are resistant to conventional means of wound therapy. This study reports the successful use of synthetic heparan sulphate (Cacipliq20(®) , OTR3, Paris, France) in the treatment of a sickle cell ulcer that had failed to respond to several other means of treatment. Therapeutic success was assessed by complete wound coverage and vast improvement in pain score. This is the first study to report use of heparan sulphate in sickle cell ulcers.
authors.affiliation: Plastic and Reconstructive Surgery, Private Practice, American University of Beirut - Medical Center, Beirut, Lebanon.
authors.forename: Shady
authors.initials: S
authors.lastname: Hayek
authors.affiliation: Plastic and Reconstructive Surgery, Private Practice, American University of Beirut - Medical Center, Beirut, Lebanon.
authors.forename: Saad
authors.initials: S
authors.lastname: Dibo
authors.affiliation: Plastic and Reconstructive Surgery, Private Practice, American University of Beirut - Medical Center, Beirut, Lebanon.
authors.forename: Joe
authors.initials: J
authors.lastname: Baroud
authors.affiliation: Plastic and Reconstructive Surgery, Private Practice, American University of Beirut - Medical Center, Beirut, Lebanon.
authors.forename: Amir
authors.initials: A
authors.lastname: Ibrahim
authors.affiliation: Laboratoire CRRET CNRS, University Paris Est Creteil, Paris, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Barritault
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D005260:Female; D006497:Heparan Sulfate / Q000627:therapeutic use*; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy* / Q000209:etiology; D064232:Visual Analog Scale; D014945:Wound Healing
chemical_list: D006497:Heparan Sulfate
keywords: Cacipliq20; Glucose amino glycans; Heparan sulphate; Sickle cell ulcer; Ulcer