title: Promising coagulation factor VIII bypassing strategies for patients with haemophilia A.
abstract: Haemophilia A is an X-linked recessive monogenic hereditary bleeding disorder caused by a deficiency or functional defect in coagulation factor VIII (FVIII). Typically, only 30% haemophilia A patients are treated with FVIII-specific products successfully. Therefore, other promising clotting factors and FVIII-bypassing factors exhibiting sufficient FVIII-independent activity, low immunogenicity and prolonged half-life are needed to conquer this malady. Here, we will systematically review the current status of the diverse FVIII-bypassing factors for the treatment of FVIII-insensitive haemophilia A patients.
authors.affiliation: aSchool of Biomedical Sciences and Institute of Molecular Medicine, Huaqiao University bEngineering Research Center of Molecular Medicine, Ministry of Education, Fujian, PR China.
authors.forename: Xunwei
authors.initials: X
authors.lastname: Duan
authors.forename: Mingqing
authors.initials: M
authors.lastname: Tang
authors.forename: Junping
authors.initials: J
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Yu
authors.forename: Ruian
authors.initials: R
authors.lastname: Xu
mesh_terms: D001779:Blood Coagulation Factors / Q000378:metabolism / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003029:Coagulants / Q000378:metabolism / Q000627:therapeutic use*; D005167:Factor VII / Q000378:metabolism / Q000627:therapeutic use; D005169:Factor VIII / Q000378:metabolism / Q000627:therapeutic use; D015942:Factor VIIa / Q000378:metabolism / Q000627:therapeutic use; D005170:Factor X / Q000378:metabolism / Q000627:therapeutic use; D015951:Factor Xa / Q000378:metabolism / Q000627:therapeutic use; D006467:Hemophilia A / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D015539:Platelet Activation / Q000187:drug effects; D011516:Prothrombin / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism / Q000627:therapeutic use; D013917:Thrombin / Q000378:metabolism
chemical_list: D001779:Blood Coagulation Factors; D003029:Coagulants; D011994:Recombinant Proteins; C427184:recombinant factor VIII SQ; D005167:Factor VII; D011516:Prothrombin; D005169:Factor VIII; D005170:Factor X; C103587:recombinant FVIIa; C065655:anti-inhibitor coagulant complex; D015942:Factor VIIa; D013917:Thrombin; D015951:Factor Xa