title: Association of SLC22A4 gene polymorphism with Rheumatoid arthritis in the Chinese population.
abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disease with complex genetic factors. Single-nucleotide polymorphisms (SNPs) in the SLC22A4 gene have been previously reported to be associated with RA in Japanese but not European populations. This study further investigated the association of SLC22A4 polymorphisms, in particular slc2F1/slc2F2, with RA in the Chinese population, the largest Asian population. A total of 160 human subjects with 95 RA patients and 65 healthy controls were genotyped for slc2F1-G/A and slc2F2-C/T polymorphisms. The results showed that there was a significant difference in the genotype distribution of these two polymorphisms between the two groups. In addition, the presence of slc2F1 A allele and slc2F2 T allele carries a 1.93-fold and 2.14-fold increased risk for anticyclic citrullinated peptide (CCP) positivity, respectively. Overall, this study provided evidence that SLC22A4 gene polymorphisms played important roles in the etiology of RA in the largest Asian population, the Chinese population.
authors.affiliation: Department of Immunology and Rheumatology, the Second People's Hospital of Wuxi, Wuxi, 214002, People's Republic of China. rentianli2012@gmail.com.
authors.forename: Tian-li
authors.initials: TL
authors.lastname: Ren
authors.forename: Zhi-jun
authors.initials: ZJ
authors.lastname: Han
authors.forename: Cheng-jian
authors.initials: CJ
authors.lastname: Yang
authors.forename: Yuan-xing
authors.initials: YX
authors.lastname: Hang
authors.forename: De-yu
authors.initials: DY
authors.lastname: Fang
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Xue
authors.initials: X
authors.lastname: Zhu
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Ji
authors.forename: Fan-fan
authors.initials: FF
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000911:Antibodies, Monoclonal / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000235:genetics* / Q000276:immunology; D044466:Asian People / Q000235:genetics*; D002097:C-Reactive Protein / Q000032:analysis; D004247:DNA / Q000097:blood / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D027701:Organic Cation Transport Proteins / Q000235:genetics*; D010456:Peptides, Cyclic / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D012217:Rheumatoid Factor / Q000032:analysis; D012720:Severity of Illness Index; D027981:Symporters
chemical_list: D000911:Antibodies, Monoclonal; D027701:Organic Cation Transport Proteins; D010456:Peptides, Cyclic; C109807:SLC22A4 protein, human; D027981:Symporters; C487763:cyclic citrullinated peptide; D002097:C-Reactive Protein; D004247:DNA; D012217:Rheumatoid Factor
keywords: Rheumatoid Arthritis; SLC22A4; Single-Nucleotide Polymorphism; slc2F1; slc2F2