title: Repair of ventricular septal defect with Eisenmenger syndrome after bosentan treatment.
abstract: We report a patient with ventricular septal defect (VSD) and Eisenmenger syndrome. The patient was treated with bosentan for 12 weeks, with a decrease in pulmonary vascular resistance index (PRVi) from 18.84 to 9.63 Wood unit (WU) m2 , and underwent successful corrective repair of the VSD after 12 weeks of bosentan therapy.
authors.affiliation: Department of Surgical Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Hu
authors.forename: Lin-Hua
authors.initials: LH
authors.lastname: Tan
authors.forename: Jing
authors.initials: J
authors.lastname: Ye
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D000077300:Bosentan; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002648:Child; D004541:Eisenmenger Complex / Q000150:complications*; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000601:surgery*; D006346:Heart Septum / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000503:physiopathology; D013449:Sulfonamides / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D014655:Vascular Resistance
chemical_list: D000959:Antihypertensive Agents; D013449:Sulfonamides; D000077300:Bosentan