title: [Immediate and long-term results of simultaneous chemoradiotherapy in non-traditional modes of fractionation in the treatment of patients with oropharyngeal squamous cell carcinoma].
abstract: The analysis of the effectiveness of treatment was carried out in 257 patients with squamous cell carcinoma of the mucous membranes of the oral cavity and oropharynx. Two methods of irradiation were used in combination with concurrent polychemotherapy: standard radiotherapy (2 Gy 5 times a week) and radiotherapy in non-traditional modes of fractionation with uneven breaking of the daily dose into two fractions (1 Gy + 1.5 Gy or 1 Gy + 2 Gy with 4-hour intervals) to a focal dose of 60 Gy. Chemoradiotherapy with fractionated dose was more effective than standard chemoradiotherapy in frequency of objective tumor responses and regional metastases in the absence of increasing the number of early radiation reactions and late radiation damages. External beam radiotherapy in non-traditional modes of fractionation with simultaneous polychemotherapy exposure can significantly improve the results of the overall five-year survival compared with conventional fractionation technique--60.4 +/- 4.5%, 63.3 +/- 8.2% vs 27.6 +/- 10.2%, respectively.
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Semin
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Mardynskiĭ
authors.forename: V S
authors.initials: VS
authors.lastname: Medvedev
authors.forename: I A
authors.initials: IA
authors.lastname: Gulidov
authors.forename: P A
authors.initials: PA
authors.lastname: Isaev
authors.forename: D N
authors.initials: DN
authors.lastname: Derbugov
authors.forename: V V
authors.initials: VV
authors.lastname: Pol'kin
authors.forename: M U
authors.initials: MU
authors.lastname: Radzsanova
authors.forename: S V
authors.initials: SV
authors.lastname: Vasil'kov
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000628:therapy*; D059248:Chemoradiotherapy; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000401:mortality / Q000628:therapy*; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome