title: High-risk oral human papillomavirus load in the US population, National Health and Nutrition Examination Survey 2009-2010.
abstract: We investigated the association of demographic and behavioral factors with oral human papillomavirus (HPV) load for 18 high-risk types among 211 individuals with prevalent high-risk HPV within the National Health and Nutrition Examination Survey 2009-2010. Factors independently associated with HPV load above the median included older age (odds ratio, 1.04 per year increase [95% confidence interval, 1.01-1.07]; P = .004) and intensity of current smoking (P for trend <.001). A marginally greater percentage of men than women had an HPV load above the median (55.7% vs 32.8%; P = .069), and HPV load increased marginally with increasing alcohol use (P for trend = .062). In conclusion, older age and current smoking are associated with a high oral load of high-risk HPV types among individuals with a prevalent infection.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National institutes of Health, Rockville, Maryland;
authors.forename: Anil K
authors.initials: AK
authors.lastname: Chaturvedi
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National institutes of Health, Rockville, Maryland;
authors.forename: Barry I
authors.initials: BI
authors.lastname: Graubard
authors.affiliation: The Ohio State University, Columbus.
authors.forename: Robert K L
authors.initials: RK
authors.lastname: Pickard
authors.affiliation: The Ohio State University, Columbus.
authors.forename: Weihong
authors.initials: W
authors.lastname: Xiao
authors.affiliation: The Ohio State University, Columbus.
authors.forename: Maura L
authors.initials: ML
authors.lastname: Gillison
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D027383:Papillomaviridae / Q000145:classification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D012307:Risk Factors; D012907:Smoking; D014481:United States / Q000453:epidemiology; D019562:Viral Load; D055815:Young Adult
keywords: Human papillomavirus (HPV); NHANES; oral; oropharynx; smoking; viral load