title: Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity.
abstract: Attenuated growth hormone and insulin-like growth factor-1 (GH/IGF-1) signaling is associated with extended lifespan in several animal models. However, the effect of diminished GH/IGF-1 activity on survival in humans has not been confirmed. We tested the hypothesis that IGF-1 levels in nonagenarians (n = 184), measured at study enrollment, predict the duration of their incremental survival. In the Kaplan-Meier analysis, females with IGF-1 levels below the median (≤ 96 ng mL(-1) ) had significantly longer survival compared with females with levels above the median, P < 0.01. However, this survival advantage was not observed in males (P = 0.83). On the other hand, in both males and females with a history of cancer, lower IGF-1 levels predicted longer survival (P < 0.01). IGF-1 level remained a significant predictor of survival duration in linear regression models after multivariable adjustment in females (P = 0.01) and individuals with a history of cancer (P < 0.01). We show for the first time that low IGF-1 levels predict life expectancy in exceptionally long-lived individuals.
authors.affiliation: Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, USA.
authors.forename: Sofiya
authors.initials: S
authors.lastname: Milman
authors.forename: Gil
authors.initials: G
authors.lastname: Atzmon
authors.forename: Derek M
authors.initials: DM
authors.lastname: Huffman
authors.forename: Junxiang
authors.initials: J
authors.lastname: Wan
authors.forename: Jill P
authors.initials: JP
authors.lastname: Crandall
authors.forename: Pinchas
authors.initials: P
authors.lastname: Cohen
authors.forename: Nir
authors.initials: N
authors.lastname: Barzilai
mesh_terms: D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D008136:Longevity / Q000502:physiology*; D008297:Male; D016019:Survival Analysis
chemical_list: D007334:Insulin-Like Growth Factor I
keywords: IGF-1; cancer; human; insulin-like growth factor 1; longevity; mortality