title: Meta-analysis of the efficacy of cold coagulation as a treatment method for cervical intraepithelial neoplasia: a systematic review.
abstract: BACKGROUND
  Cold coagulation is an ablative method for treatment of cervical intraepithelial neoplasia (CIN). Despite reports of efficacy against all grades of CIN (CIN1-3), cold coagulation has been infrequently used since the 1980s, and was absent from the recent Cochrane review on CIN treatment.
  
  
  OBJECTIVE
  To provide a systematic review of cold coagulation efficacy and acceptability for CIN treatment through meta-analysis of clinical reports and a randomised control trial.
  
  
  METHODS
  A literature search in PubMed, Web of Science, EMBASE, and regional databases yielded 388 papers. Title, abstract and/or reference list review identified 22 papers describing cold coagulation treatment of CIN, with 13 providing adequate data for inclusion in the meta-analysis.
  
  
  METHODS
  Publications or conference abstracts describing original data (number of women treated, followed up and cured, provider type, cure definition) were retained. No language or publication date limitations were imposed.
  
  
  METHODS
  Data extracted from 13 studies were pooled, and statistical analyses of proportion cured were conducted with data stratified by lesion grade and study region.
  
  
  RESULTS
  Among 4569 CIN patients treated with cold coagulation, summary proportion cured of 96% [95% confidence interval (CI) 92-99%] and 95% (92-98%) were obtained for CIN1 and CIN2-3 disease, respectively. Side-effects and adverse effects were infrequent, and fertility was not impaired.
  
  
  CONCLUSIONS
  Cold coagulation CIN cure rates were comparable to those of other excisional and ablative methods. Cold coagulation is indicated for all grades of CIN, is safe, quick and acceptable, and may be of particular relevance for use in resource-limited settings.
authors.affiliation: Department of Human Genetics, McGill University, Montreal, QC, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Dolman
authors.forename: C
authors.initials: C
authors.lastname: Sauvaget
authors.forename: R
authors.initials: R
authors.lastname: Muwonge
authors.forename: R
authors.initials: R
authors.lastname: Sankaranarayanan
mesh_terms: D003080:Cold Temperature; D003452:Cryosurgery / Q000379:methods*; D004564:Electrocoagulation / Q000379:methods*; D005260:Female; D006801:Humans; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000601:surgery*
keywords: Acceptability; cervical intraepithelial neoplasia; cold coagulation; efficacy; pooled analysis