title: Effect of preeclampsia on insulin sensitivity.
abstract: OBJECTIVE
  The objective of this study is to investigate whether preeclampsia is associated with exacerbation of insulin resistance.
  
  
  METHODS
  The study was conducted over a period of 7 months from November 2011 to May 2012, in a tertiary care hospital attached to a medical college. A total of 14 pregnant women in the third trimester with preeclampsia were recruited for this study and 14 well-matched normotensive women in the third trimester were taken as control. 15 g, 50% dextrose load was given intravenously and blood sampling was carried out for glucose and insulin levels up to 3 h afterward. Minimal model analysis of glucose and insulin levels was performed to arrive at results.
  
  
  RESULTS
  No significant changes in mean age, body mass index, gestation, serum lipid and progesterone, cortisol and androgen concentrations were recognized. No significant difference was found between the glucose decay curves and between the glucose clearance rate K, in the two groups (preeclamptic vs. normotensive: 2.1 ± 0.2 vs. 2.2 ± 0.3; P = 0.48). Therefore, there was a small but prolonged decrease in the insulin response of women with preeclampsia compared with women in the normotensive group.
  
  
  CONCLUSIONS
  Preeclampsia per se is not a risk factor for development of insulin resistance.
authors.affiliation: Department of Obstetrics and Gynaecology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Smita
authors.initials: S
authors.lastname: Sinha
authors.affiliation: Department of Medicine, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Gobind Pratap
authors.initials: GP
authors.lastname: Singh
authors.affiliation: Department of Biochemistry, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Kapil
authors.initials: K
authors.lastname: Gupta
authors.affiliation: Department of Obstetrics and Gynaecology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Satwant
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Obstetrics and Gynaecology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Aekta
authors.initials: A
authors.lastname: Gupta
keywords: Glucose tolerance; insulin sensitivity; preeclampsia