title: New molecular strategies for reducing implantable medical devices associated infections.
abstract: Due to the great prevalence of persistent and recurrent implanted device associated-infections novel and alternative therapeutic approaches are intensely investigated. For reducing complications and antibiotic resistance development, one major strategy is using natural or synthetic modulators for targeting microbial molecular pathways which are not related with cell multiplication and death, as Quorum Sensing, virulence and biofilm formation. The purpose of this review paper is to discuss the most recent in vitro approaches, investigating the efficiency of some novel antimicrobial products and the nano-technologic progress performed in order to increase their effect and stability.
authors.forename: Alina Maria
authors.initials: AM
authors.lastname: Holban
authors.forename: Monica Cartelle
authors.initials: MC
authors.lastname: Gestal
authors.affiliation: Faculty of Applied Chemistry and Materials Science, "Politehnica" University of Bucharest, Department of Science and Engineering of Oxide Materials and Nanomaterials, 1-7 Polizu Street, 011061 Bucharest, Romania. grumezescu@yahoo.com.
authors.forename: Alexandru Mihai
authors.initials: AM
authors.lastname: Grumezescu
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000378:metabolism / Q000472:pathogenicity; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D005658:Fungi / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D008826:Microbial Sensitivity Tests; D050997:Nanomedicine / Q000379:methods*; D016459:Prosthesis-Related Infections / Q000382:microbiology* / Q000517:prevention & control*; D053038:Quorum Sensing / Q000187:drug effects; D014774:Virulence / Q000187:drug effects; D014780:Viruses / Q000187:drug effects* / Q000472:pathogenicity
chemical_list: D000890:Anti-Infective Agents