title: Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(-/-) Collies after oral administration.
abstract: BACKGROUND
  Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. This study investigated the safety of oral administration of fluralaner at 3 times the highest expected clinical dose to Multi Drug Resistance Protein 1 (MDR1(-/-)) gene defect Collies.
  
  
  METHODS
  Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. Eight Collies received fluralaner chewable tablets once at a dose of 168 mg/kg; eight sham dosed Collies served as controls. All Collies were clinically observed until 28 days following treatment.
  
  
  RESULTS
  No adverse events were observed subsequent to fluralaner treatment of MDR1(-/-) Collies at three times the highest expected clinical dose.
  
  
  CONCLUSIONS
  Fluralaner chewable tablets are well tolerated in MDR1(-/-) Collies following oral administration.
authors.affiliation: MSD Animal Health Innovation GmbH, Zur Propstei, 55270 Schwabenheim, Germany. feli.walther@msd.de.
authors.forename: Feli M
authors.initials: FM
authors.lastname: Walther
authors.forename: Allan J
authors.initials: AJ
authors.lastname: Paul
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Allan
authors.forename: Rainer K A
authors.initials: RK
authors.lastname: Roepke
authors.forename: Martin C
authors.initials: MC
authors.lastname: Nuernberger
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000284:Administration, Oral; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D004285:Dogs / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007555:Isoxazoles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D012449:Safety; D017384:Sequence Deletion; D012737:Sex Factors; D016037:Single-Blind Method; D013607:Tablets; D013997:Time Factors
chemical_list: C000591860:A1443 compound; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000977:Antiparasitic Agents; D007555:Isoxazoles; D013607:Tablets