title: [The effect of mild hypobaric hypoxia regime on expression of factor induced by hypoxia in the rat neocortex].
abstract: Using quantitative immunohistochemistry, modifications of HIF-1alpha expression in neocortex of rats exposed to various modes of mild hypobaric hypoxia (MHH) (1,3 and 6 episodes) differed in their neuroprotective efficacy have been studied. It has been shown that three-trial MHH being the most effective neuroprotective mode when used as a preconditioning produces most considerable changes in HIF-1 by substantial up-regulation of its regulatory alpha-subunit expression in the rat neocortex. Present findings support the hypothesis on important roles of HIF-1 in the mechanisms of brain hypoxic tolerance induced by the hypoxic preconditioning with three-trial MHH.
authors.forename: M V
authors.initials: MV
authors.lastname: Sidorova
authors.forename: E A
authors.initials: EA
authors.lastname: Rybnikova
authors.forename: A V
authors.initials: AV
authors.lastname: Churilova
authors.forename: V I
authors.initials: VI
authors.lastname: Portnichenko
authors.forename: M O
authors.initials: MO
authors.lastname: Sanoĭlov
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000096:biosynthesis*; D007150:Immunohistochemistry; D008297:Male; D019579:Neocortex / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit