title: Development of the crosslinking reactions to RNA triggered by oxidation.
abstract: A novel crosslink-forming nucleobase, 2-amino-6-(1-ethylthiovinyl)purine (ATVP), which is triggered by the oxidation of sulfide to sulfoxide, has been developed. The oxidation of ATVP within the duplex proceeded with H2O2 and FeCl2. We have successfully developed the crosslinking reactions activated by oxidation.
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, 980-8577, Japan. nagatugi@tagen.tohoku.ac.jp.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Kusano
authors.forename: Takuya
authors.initials: T
authors.lastname: Haruyama
authors.forename: Shogo
authors.initials: S
authors.lastname: Ishiyama
authors.forename: Shinya
authors.initials: S
authors.lastname: Hagihara
authors.forename: Fumi
authors.initials: F
authors.lastname: Nagatsugi
mesh_terms: D015075:2-Aminopurine / Q000031:analogs & derivatives* / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012313:RNA / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry; D013454:Sulfoxides / Q000138:chemical synthesis / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D003432:Cross-Linking Reagents; D013440:Sulfides; D013454:Sulfoxides; D014753:Vinyl Compounds; D015075:2-Aminopurine; D012313:RNA