title: Severe autogenously fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion. Response to intra peritoneal moxifloxacin combined with dexamethasone.
abstract: OBJECTIVE
  To evaluate the treatment outcome of severe peritonitis in rats submitted to permanent bilateral carotid occlusion (PBCO).
  
  
  METHODS
  Sixteen Wistar rats (mean age of 8.5 months) with PBCO underwent autogenously fecal peritonitis, and were treated with moxifloxacin combined with dexamethasone, and followed-up for 45 days. Ten rats (mean age five months) without PBCO were used as a control group. The variables were expressed by their mean and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee.
  
  
  RESULTS
  There was a significant increase (p=0.0002) in the mortality and morbidity in older rats that underwent PBCO (study group). However, even among the survival rats presenting with severe residual abscesses both in the abdomen and thorax cavities, they present an almost normal life.
  
  
  CONCLUSIONS
  The treatment of severe autogenously fecal peritonitis with intraperitoneal moxifloxacin combined with dexamethasone was very effective in young rats without permanent bilateral carotid occlusion. The treatment reached reasonable results in older rats with PBCO, even considering residual abscesses on abdomen and thorax. Older age was the greater risk factor for the outcome of the treatment of severe peritonitis. Sepsis remains a challenging situation, especially in elderly.
authors.affiliation: Campina Grande Faculty of Medicine, Department of Ophthalmology, Campina GrandePB, Brazil, IFellow PhD degree, Postgraduate Program in Surgery, Health Sciences Center, Federal University of Pernambuco (UFPE). Assistant Professor, Department of Ophthalmology, Campina Grande Faculty of Medicine (FCM), Campina Grande-PB, Brazil. Acquisition and interpretation of data, manuscript writing.
authors.forename: Maria Cecília Santos Cavalcanti
authors.initials: MC
authors.lastname: Melo
authors.affiliation: FCM, Department of Ophthalmology, Campina GrandePB, Brazil, IIFellow PhD degree, Postgraduate Program in Surgery, Health Sciences Center, UFPE, Recife-PE. Associate Professor, Department of Ophthalmology, FCM, Campina Grande-PB, Brazil. Manuscript writing, critical revision.
authors.forename: Diego Nery Benevides
authors.initials: DN
authors.lastname: Gadelha
authors.affiliation: Campina Grande University, Campina GrandePB, Brazil, IIIFellow Master Degree in Agricultural Engineering, Federal Campina Grande University (UFCG)-PB, Campina Grande-PB, Brazil. Acquisition and interpretation of data.
authors.forename: Thárcia Kiara Beserra
authors.initials: TK
authors.lastname: Oliveira
authors.affiliation: UFPE, Campina GrandePB, Brazil, IVPhD, Head Professor, Scientific Methodology and Pediatric Surgery, UFPE, Recife-PE. Coordinator, FCM, Campina Grande-PB, Brazil. Interpretation of data, English version. final revision.
authors.forename: Carlos Teixeira
authors.initials: CT
authors.lastname: Brandt
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D017536:Carotid Artery, Common; D003907:Dexamethasone / Q000627:therapeutic use*; D004338:Drug Combinations; D005243:Feces; D024841:Fluoroquinolones / Q000627:therapeutic use*; D023421:Models, Animal; D000077266:Moxifloxacin; D010538:Peritonitis / Q000188:drug therapy* / Q000473:pathology; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013997:Time Factors; D000267:Tissue Adhesions; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D024841:Fluoroquinolones; D003907:Dexamethasone; D000077266:Moxifloxacin