title: Efficient covalent capture of 8-nitroguanosine via a multiple hydrogen-bonded complex.
abstract: A novel 1,3-diazaphenoxazine nucleoside derivative (nitroG-Grasp) bearing a thiol group with a urea linker forms multiple hydrogen-bonded complexes with 8-nitroguanosine and efficiently displaces the nitro group; thus, it is the first molecule that can covalently capture 8-nitroguanosine.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Fuchi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D006151:Guanosine / Q000031:analogs & derivatives* / Q000737:chemistry; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D014508:Urea / Q000737:chemistry
chemical_list: C481144:8-nitroguanosine; D009574:Nitro Compounds; D013438:Sulfhydryl Compounds; D006151:Guanosine; D014508:Urea