title: Periosteum-mimetic structures made from freestanding microgrooved nanosheets.
abstract: A "sticker-like" PLGA nanosheet with microgrooved patterns is developed through a facile combination of spin coating and micropatterning techniques. The resulting microgrooved PLGA nanosheets can be physically adhered on flat or porous surfaces with excellent stability in aqueous environments and can harness the spatial arrangements of cells, which make it a promising candidate for generating biomimic periosteum for bone regenerative applications.
authors.affiliation: WPI-Advanced Institute for Materials Research, Tohoku University, Sendai, 980-8578, Japan.
authors.forename: Xuetao
authors.initials: X
authors.lastname: Shi
authors.forename: Toshinori
authors.initials: T
authors.lastname: Fujie
authors.forename: Akihiro
authors.initials: A
authors.lastname: Saito
authors.forename: Shinji
authors.initials: S
authors.lastname: Takeoka
authors.forename: Ying
authors.initials: Y
authors.lastname: Hou
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Shu
authors.forename: Mingwei
authors.initials: M
authors.lastname: Chen
authors.forename: Hongkai
authors.initials: H
authors.lastname: Wu
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D001842:Bone and Bones / Q000737:chemistry; D002448:Cell Adhesion; D002478:Cells, Cultured; D002645:Chickens; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D059630:Mesenchymal Stem Cells / Q000502:physiology; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry*; D010012:Osteogenesis; D010521:Periosteum / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D054457:Tissue Scaffolds; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid
keywords: adhesiveness; bone repair; micropattern; nanosheet; periosteum