title: Simultaneous identification of 18 illegal adulterants in dietary supplements by using high-performance liquid chromatography-mass spectrometry.
abstract: We developed a method for the identification of 18 illegal adulterants in dietary supplements for erectile dysfunction by using high-performance liquid chromatography-mass spectrometry. The separation was achieved on a Cosmosil 3C18-EB column. The mobile phase consisted of 0.1% formic acid solution and 0.1% formic acid in acetonitrile, with gradient elution at a flow rate of 0.15 mL/min. The proposed method may be useful for the identification of illegal adulterants and for quality control of dietary supplements.
authors.affiliation: Osaka Prefectural Institute of Public Health.
authors.forename: Takaomi
authors.initials: T
authors.lastname: Tagami
authors.forename: Airin
authors.initials: A
authors.lastname: Aoyama
authors.forename: Akihiro
authors.initials: A
authors.lastname: Takeda
authors.forename: Akiko
authors.initials: A
authors.lastname: Asada
authors.forename: Takahiro
authors.initials: T
authors.lastname: Doi
authors.forename: Keiji
authors.initials: K
authors.lastname: Kajimura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sawabe
mesh_terms: D000097:Acetonitriles; D052117:Benzodioxoles / Q000302:isolation & purification; D002243:Carbolines / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D019587:Dietary Supplements / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis* / Q000331:legislation & jurisprudence*; D005561:Formates; D013058:Mass Spectrometry / Q000379:methods*; D058986:Phosphodiesterase 5 Inhibitors / Q000302:isolation & purification; D010879:Piperazines / Q000302:isolation & purification; D011687:Purines / Q000302:isolation & purification; D011786:Quality Control; D000068677:Sildenafil Citrate; D012996:Solutions; D013450:Sulfones / Q000302:isolation & purification; D000068581:Tadalafil; D064804:Urological Agents / Q000302:isolation & purification; D014665:Vasodilator Agents / Q000302:isolation & purification
chemical_list: D000097:Acetonitriles; D052117:Benzodioxoles; D002243:Carbolines; D005561:Formates; D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D012996:Solutions; D013450:Sulfones; D064804:Urological Agents; D014665:Vasodilator Agents; C030544:formic acid; D000068581:Tadalafil; D000068677:Sildenafil Citrate; C551065:aminotadalafil; C032159:acetonitrile