title: Controlled protein delivery from photosensitive nanoparticles.
abstract: Light provides a powerful approach for delivery of cargos and study of important biological events. This article reports a series of photosensitive and biocompatible delivery of nanoparticles which released proteins upon light irradiation. The nanoparticles were synthesized by emulsion copolymerization of 2-(dimethylamino) ethyl methacrylate with functional monomers and a photoliable o-nitrobenzyl diacrylate crosslinker. Upon mild UV irradiation (λ = 365 nm, 10 mJ/cm(2)), the photosensitive crosslinker underwent light-induced degradation and the sizes of the nanoparticles increased dramatically. The nanoparticles were uptaken by the cells which is confirmed by flow cytometry analysis. Bovine serum albumin and green fluorescent protein were loaded as model proteins into the nanoparticles and accelerated photo-triggered release were achieved.
authors.affiliation: School of Material Science, Ningbo University of Technology, Ningbo, Zhejiang, 315211, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Jiang
authors.forename: Huyan
authors.initials: H
authors.lastname: Li
authors.forename: Yujing
authors.initials: Y
authors.lastname: You
authors.forename: Xuedong
authors.initials: X
authors.lastname: Wu
authors.forename: Shuangxi
authors.initials: S
authors.lastname: Shao
authors.forename: Qun
authors.initials: Q
authors.lastname: Gu
mesh_terms: D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D008027:Light; D053758:Nanoparticles; D011506:Proteins / Q000008:administration & dosage*
chemical_list: D011506:Proteins
keywords: controlled drug delivery; nanoparticle; photosensitive