title: Estrogen receptor α gene PvuII polymorphism and coronary artery disease: a meta-analysis of 21 studies.
abstract: The association between the estrogen receptor α gene (ESR1) PvuII polymorphism (c.454-397T>C) and coronary artery disease (CAD) is controversial. Thus, we conducted a meta-analysis to evaluate the relationship. Data were collected from 21 studies encompassing 9926 CAD patients and 16710 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the relationship between PvuII polymorphism and CAD. The polymorphism in control populations in all studies followed Hardy-Weinberg equilibrium. We found a significant association between ESR1 PvuII polymorphism and CAD risk in all subjects. When the data were stratified by region, a significant association between ESR1 PvuII polymorphism and CAD risk was observed in Asian populations but not in Western populations. The current study suggests that ESR1 PvuII polymorphism has an important role in CAD susceptibility.
authors.affiliation: Department of Cardiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Xiuzhou District, Gaozhao Street Community Health Service Center, Jiaxing 314031, China; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Ding
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
authors.forename: Xiang
authors.initials: X
authors.lastname: Yin
authors.forename: Fu-rong
authors.initials: FR
authors.lastname: Zhang
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Pan
authors.forename: Yi-an
authors.initials: YA
authors.lastname: Gu
authors.forename: Jun-zhu
authors.initials: JZ
authors.lastname: Chen
authors.forename: Xiao-gang
authors.initials: XG
authors.lastname: Guo
mesh_terms: D044466:Asian People / Q000235:genetics; D003324:Coronary Artery Disease / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha