title: Subacute effect of decabromodiphenyl ethane on hepatotoxicity and hepatic enzyme activity in rats.
abstract: Information regarding decabromodiphenyl ethane (DBDPE) effects on hepatotoxicity and metabolism is limited. In the present study, Wistar rats were given oral DBDPE at different doses. DBDPE induced oxidative stress, elevated blood glucose levels, increased CYP2B2 mRNA, CYP2B1/2 protein, 7-pentoxyresorufin O-depentylase (PROD) activity, and induced CYP3A2 mRNA, CYP3A2 protein, and luciferin benzylether debenzylase (LBD) activity. UDPGT activity increased with its increasing exposure levels, suggesting that oral DBDPE exposure induces drug-metabolizing enzymes in rats via the CAR/PXR signaling pathway. The induction of CYPs and co-regulated enzymes of phase II biotransformation may affect the homeostasis of endogenous substrates, including thyroid hormones, which may, in turn, alter glucose metabolism.
authors.affiliation: Beijing Institute of Disease Control and Prevention, Beijing 100071, China; Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China; Tianjin Key Laboratory of Risk Assessment and Control for Environmental and Food Safety, Tianjin 300050, China.
authors.forename: Ru Bao
authors.initials: RB
authors.lastname: Sun
authors.affiliation: Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China; Tianjin Key Laboratory of Risk Assessment and Control for Environmental and Food Safety, Tianjin 300050, China.
authors.forename: Zhu Ge
authors.initials: ZG
authors.lastname: Xi
authors.affiliation: Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China; Tianjin Key Laboratory of Risk Assessment and Control for Environmental and Food Safety, Tianjin 300050, China.
authors.forename: Hua Shan
authors.initials: HS
authors.lastname: Zhang
authors.affiliation: Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China; Tianjin Key Laboratory of Risk Assessment and Control for Environmental and Food Safety, Tianjin 300050, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001969:Bromobenzenes / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology*; D005260:Female; D005411:Flame Retardants / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018675:Toxicity Tests
chemical_list: D001969:Bromobenzenes; D005411:Flame Retardants; C491509:decabromodiphenyl ethane