title: Fabrication of multifunctional layer-by-layer nanocapsules toward the design of theragnostic nanoplatform.
abstract: Self-assembled polymeric nanocapsules (NCs) that incorporate dendrimer porphyrin (DP) in the shells and superparamagnetic iron oxide nanoparticles (SPIONs) in the cores are fabricated to create a theragnostic platform for the application in photodynamic therapy (PDT) and magnetic resonance imaging (MRI). SPIONs-embedded polystyrene NPs (SPIONs@PS) are used as a template to build up multilayered NCs. The formation of PAH/DP multilayer on the SPIONs@PS is monitored by zeta-pential and fluorescence emission measurement, because the porphyrin unit in the core of DP has strong red fluorescence emission. NCs have strong enough magnetic property (>20 emu/g) for MRI application with typical superparamagnetic behavior, where the linear correlation of R2 and Fe concentration at diluted conditions led to corresponding T2 relaxivity coefficient (r2) value of 93.5 mM(-1) s(-1). Cell viability study upon light irradiation reveals that NCs can successfully work in photosensitizer formulation for PDT.
authors.affiliation: Department of Chemistry and ‡Department of Chemical and Biomolecular Engineering, Yonsei University , 50 Yonsei-ro, Seodaemun-Gu, Seoul 120-749, Korea.
authors.forename: Hee-Jae
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Tae Geuk
authors.initials: TG
authors.lastname: Lim
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Young Min
authors.initials: YM
authors.lastname: Cho
authors.forename: Yong Seok
authors.initials: YS
authors.lastname: Kim
authors.forename: Ui Seok
authors.initials: US
authors.lastname: Chung
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Byoung Wook
authors.initials: BW
authors.lastname: Choi
authors.forename: Won-Gun
authors.initials: WG
authors.lastname: Koh
authors.forename: Woo-Dong
authors.initials: WD
authors.lastname: Jang
mesh_terms: D050091:Dendrimers / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D005453:Fluorescence; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053769:Nanocapsules / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D036103:Nanotechnology / Q000379:methods*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry; D011073:Polyamines / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000032:analysis
chemical_list: D050091:Dendrimers; D005290:Ferric Compounds; D053769:Nanocapsules; D017319:Photosensitizing Agents; D011073:Polyamines; D011137:Polystyrenes; D011166:Porphyrins; D017382:Reactive Oxygen Species; C000499:ferric oxide; C063994:polyallylamine