title: Heps with pep: direct reprogramming into human hepatocytes.
abstract: The limited supply and expansion capacity of primary human hepatocytes presents major challenges for pharmaceutical applications and development of cell-based therapies for liver diseases. Now in Cell Stem Cell, two papers demonstrate efficient direct reprogramming of human fibroblasts into induced hepatocytes, which exhibit metabolic properties similar to primary hepatocytes.
authors.affiliation: Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Institute for Regenerative Medicine, Department of Surgery, West Forvie Site, Robinson Way, Cambridge CB20SZ, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address: lv225@cam.ac.uk.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Vallier
mesh_terms: D000818:Animals; D019070:Cell Lineage; D065150:Cellular Reprogramming; D005347:Fibroblasts / Q000166:cytology*; D022781:Hepatocytes / Q000166:cytology* / Q000378:metabolism*; D006801:Humans