title: Genome-wide association analysis for growth, muscularity and meat quality in Piétrain pigs.
abstract: Improvement in growth and meat quality is one of the main objectives in sire line pig breeding programmes. Mapping quantitative trait loci for these traits using experimental crosses and a linkage-based approach has been performed frequently in the past. The Piétrain breed often was involved as a founder breed to establish the experimental crosses. This breed was selected for muscularity and leanness but shows relatively poor meat quality. It is frequently used as a sire line breed. With the advent of genome-wide and dense SNP chips in pig genomic research, it is possible to also conduct genome-wide association studies within the Piétrain breed. In this study, around 500 progeny-tested sires were genotyped with 60k SNPs. Data filtering showed that around 48k SNPs were useable in this sample. These SNPs were used to conduct a genome-wide association study for growth, muscularity and meat quality traits. Because it is known that a mutation in the RYR1 gene located on chromosome 6 shows a major effect on meat quality, this mutation was included in the models. Single-marker and multimarker association analyses were performed. The results revealed between zero and eight significant associations per trait with P < 5 × 10(-5) . Of special interest are SNPs located on SSC6, SSC10 and SSC15.
authors.affiliation: Institute of Animal Husbandry and Breeding, University of Hohenheim, D-70599, Stuttgart, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Stratz
authors.forename: R
authors.initials: R
authors.lastname: Wellmann
authors.forename: S
authors.initials: S
authors.lastname: Preuss
authors.forename: K
authors.initials: K
authors.lastname: Wimmers
authors.forename: J
authors.initials: J
authors.lastname: Bennewitz
mesh_terms: D000818:Animals; D001947:Breeding; D055106:Genome-Wide Association Study / Q000662:veterinary*; D005858:Germany; D008297:Male; D008460:Meat / Q000592:standards*; D018482:Muscle, Skeletal / Q000254:growth & development / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide; D034421:Sus scrofa / Q000235:genetics / Q000254:growth & development / Q000502:physiology*
keywords: BayesC; meat performance; single-marker analysis