title: Identifying genetic relatives without compromising privacy.
abstract: The development of high-throughput genomic technologies has impacted many areas of genetic research. While many applications of these technologies focus on the discovery of genes involved in disease from population samples, applications of genomic technologies to an individual's genome or personal genomics have recently gained much interest. One such application is the identification of relatives from genetic data. In this application, genetic information from a set of individuals is collected in a database, and each pair of individuals is compared in order to identify genetic relatives. An inherent issue that arises in the identification of relatives is privacy. In this article, we propose a method for identifying genetic relatives without compromising privacy by taking advantage of novel cryptographic techniques customized for secure and private comparison of genetic information. We demonstrate the utility of these techniques by allowing a pair of individuals to discover whether or not they are related without compromising their genetic information or revealing it to a third party. The idea is that individuals only share enough special-purpose cryptographically protected information with each other to identify whether or not they are relatives, but not enough to expose any information about their genomes. We show in HapMap and 1000 Genomes data that our method can recover first- and second-order genetic relationships and, through simulations, show that our method can identify relationships as distant as third cousins while preserving privacy.
authors.affiliation: Department of Computer Science, University of California, Los Angeles, Los Angeles, California 90095,USA;
authors.forename: Dan
authors.initials: D
authors.lastname: He
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Furlotte
authors.forename: Farhad
authors.initials: F
authors.lastname: Hormozdiari
authors.forename: Jong Wha J
authors.initials: JW
authors.lastname: Joo
authors.forename: Akshay
authors.initials: A
authors.lastname: Wadia
authors.forename: Rafail
authors.initials: R
authors.lastname: Ostrovsky
authors.forename: Amit
authors.initials: A
authors.lastname: Sahai
authors.forename: Eleazar
authors.initials: E
authors.lastname: Eskin
mesh_terms: D005190:Family; D030661:Genetic Privacy; D036281:Genetic Research; D015894:Genome, Human; D023281:Genomics; D060148:HapMap Project; D016045:Human Genome Project; D006801:Humans