title: Interleukin-6 levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  The aim of this study was to evaluate serum concentrations of interleukin-6 (IL-6) in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS).
  
  
  METHODS
  A total of 40 women with PCOS and 40 age-matched controls were eligible for the study. Hirsutism scores, hormonal and metabolic profile as well as IL-6 levels were evaluated in each subject.
  
  
  RESULTS
  Women with PCOS exhibited higher body mass index (BMI) and serum concentrations of IL-6 levels than controls (p < 0.05); however, levels of IL-6 were not significantly increased when compared with BMI-matched controls (p > 0.05). IL-6 levels were significantly correlated positively with BMI and triglyceride levels; however, negatively correlated with high-density lipoprotein levels.
  
  
  CONCLUSIONS
  The data of this study suggested that serum IL-6 levels were found to be higher in women with PCOS as compared to controls; however, IL-6 levels might be dependent on nutritional status but not on PCOS per se. Raised serum IL-6 levels may be related to BMI and serum lipid levels and may be a predictor for cardiometabolic risks.
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Muğla Sıtkı Koçman University , Muğla , Turkey .
authors.forename: Mert
authors.initials: M
authors.lastname: Küçük
authors.forename: Sündüz Özlem
authors.initials: SÖ
authors.lastname: Altınkaya
authors.forename: Sümeyra
authors.initials: S
authors.lastname: Nergiz
authors.forename: Selda Demircan
authors.initials: SD
authors.lastname: Sezer
authors.forename: Hasan
authors.initials: H
authors.lastname: Yüksel
authors.forename: İhsan
authors.initials: İ
authors.lastname: Bağlı
authors.forename: Gülserap
authors.initials: G
authors.lastname: Yıldız
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology; D015228:Hypertriglyceridemia / Q000209:etiology*; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D009765:Obesity / Q000150:complications*; D050177:Overweight / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D011446:Prospective Studies; D012720:Severity of Illness Index; D013739:Testosterone / Q000097:blood; D015854:Up-Regulation; D055815:Young Adult
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D008075:Lipoproteins, HDL; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate
keywords: Interleukin-6; inflammation; polycystic ovary syndrome