title: Long-term follow-up after reimplantation of tumorous mandible bone treated with combination of decalcification and lyophilization.
abstract: Mandibular resection requires reconstruction, with often unsatisfactory morphofunctional results. Reimplantation of the resected mandible itself is one of ideal solutions to this problem. However, both devitalization of tumor cells involved in resected bone and preservation of osteoinductive activity are required for successful results. Lyophilization appears to enable devitalization of tumor cells, and decalcified bone implants are likely to have osteoinductive potential. Accordingly, we speculated that decalcification and lyophilization of resected bone would be an appropriate method for mandibular reconstruction. However, there is no study on the reimplantation of mandibles treated with these methods to date. The purpose of this study was to estimate the long-term follow-up of reimplanted mandibles treated with decalcification and lyophilization. Presented here are 2 patients of reimplanted mandibles treated by decalcification and lyophilization who were followed up for 8 and 9 years. We observed a good incorporation of the graft in 1 case, but severe absorption in the other. Our results suggest that treatment with decalcification and lyophilization is 1 strategy for reimplantation of the resected bone in mandibular reconstruction, but further study is needed to prevent absorption of the reimplanted bone over the long term.
authors.affiliation: From the *Division of Maxillofacial Surgery, Department of Science of Physical Functions, Kyushu Dental University, Kitakyushu, Fukuoka; †Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Nagasaki; ‡Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui, Fukui; and §Department of Regenerative Oral Surgery, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Uehara
authors.forename: Tsugio
authors.initials: T
authors.lastname: Inokuchi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sano
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tominaga
authors.forename: Izumi
authors.initials: I
authors.lastname: Asahina
mesh_terms: D003131:Combined Modality Therapy; D003648:Decalcification Technique; D005260:Female; D005500:Follow-Up Studies; D005612:Freeze Drying; D006801:Humans; D008297:Male; D008334:Mandible / Q000473:pathology* / Q000601:surgery*; D008339:Mandibular Neoplasms / Q000473:pathology* / Q000601:surgery*; D063175:Mandibular Reconstruction / Q000379:methods*; D008875:Middle Aged; D012092:Replantation / Q000379:methods*