title: Malignant hemangiosarcoma in a renal allograft: diagnostic difficulties and clinical course after nephrectomy and immunostimulation.
abstract: Hemangiosarcomas are rare tumors of endothelial cell origin. To date, only 20 cases of hemangiosarcoma have been described after renal transplantation, occurring mostly in the skin or in a dialysis fistula. We report a primary metastasizing hemangiosarcoma arising from a renal allograft. The patient was treated with transplant nephrectomy, discontinuation of immunosuppression, and immunostimulation with pegylated interferon-α-2a and has now been in complete remission for 3 years.
authors.affiliation: Department of Nephrology, Kantonsspital Baden, Baden, Switzerland.
authors.forename: Daniela
authors.initials: D
authors.lastname: Kuntzen
authors.forename: Majida
authors.initials: M
authors.lastname: Tufail Hanel
authors.forename: Thomas
authors.initials: T
authors.lastname: Kuntzen
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Yurtsever
authors.forename: Jan
authors.initials: J
authors.lastname: Tuma
authors.forename: Helmut
authors.initials: H
authors.lastname: Hopfer
authors.forename: Oliver
authors.initials: O
authors.lastname: Springer
authors.forename: Andreas
authors.initials: A
authors.lastname: Bock
mesh_terms: D064591:Allografts; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000628:therapy; D016030:Kidney Transplantation; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C100416:peginterferon alfa-2a
keywords: interferon; kidney neoplasms; kidney transplantation; tumor