title: Biomolecular and clinical practice in malignant pleural mesothelioma and lung cancer: what thoracic surgeons should know.
abstract: Today, molecular-profile-directed therapy is a guiding principle of modern thoracic oncology. The knowledge of new biomolecular technology applied to the diagnosis, prognosis, and treatment of lung cancer and mesothelioma should be part of the 21st century thoracic surgeons' professional competence. The European Society of Thoracic Surgeons (ESTS) Biology Club aims at providing a comprehensive insight into the basic biology of the diseases we are treating. During the 2013 ESTS Annual Meeting, different experts of the field presented the current knowledge about diagnostic and prognostic biomarkers in malignant pleural mesothelioma including new perspectives as well as the role and potential application of microRNA and genomic sequencing for lung cancer, which are summarized in the present article.
authors.affiliation: Division of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland isabelle.schmitt-opitz@usz.ch.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Opitz
authors.affiliation: Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Raphael
authors.initials: R
authors.lastname: Bueno
authors.affiliation: Imperial College and the Academic Division of Thoracic Surgery, The Royal Brompton Hospital, London, UK.
authors.forename: Eric
authors.initials: E
authors.lastname: Lim
authors.affiliation: Department of Cardiothoracic Surgery, NYU Langone Medical Center, New York, NY, USA.
authors.forename: Harvey
authors.initials: H
authors.lastname: Pass
authors.affiliation: Division of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: Pastorino
authors.affiliation: Tumor Genomics Unit, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: Mattia
authors.initials: M
authors.lastname: Boeri
authors.affiliation: Department of Thoracic Surgery and Oncology, Instituto Nazionale Tumori, Fondazione "G. Pascale", IRCCS, Naples, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Rocco
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D023281:Genomics / Q000379:methods; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery*; D008654:Mesothelioma / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery*; D000086002:Mesothelioma, Malignant; D035683:MicroRNAs / Q000235:genetics; D025202:Molecular Diagnostic Techniques / Q000379:methods; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Biomarker; Genomic sequencing; Lung cancer; Malignant pleural mesothelioma; microRNAs