title: Main influencing factors and health-related quality of life issues in patients with oesophago-gastric cancer - as measured by EORTC tools.
abstract: OBJECTIVE
  To assess influencing factors and main health-related quality of life (HRQoL) issues in patients with cancers of the oesophago-gastric region using the European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire Core 30 (QLQ-C30) and its oesophago-gastric module (QLQ-OG25).
  
  
  METHODS
  Patients were qualified for this study based on the histological confirmation of oesophageal, oesophago-gastric or gastric cancers. Each patient filled out the Polish version of the EORTC QLQ-C30, the QLQ-OG25 module and a personal questionnaire. Patients were divided into groups based on gender, age, treatment intention, tumour localization, working status and level of education.
  
  
  RESULTS
  Our study included 112 patients - 39 women (35%) and 73 men (mean age ± SD; 60.2 ±10.9). Thirty-five patients (31.3%) completed the questionnaires twice. Eighty-four (75%) patients had gastric cancer (GC), twenty-six (23.2%) oesophageal cancer (OC) and two (1.8%) cancer of the oesophago-gastric junction (OGJC). Eighty (71.4%) patients underwent surgical treatment prior to either chemo-, radio- or chemoradiotherapy. The Global Health Status scale of the QLQ-C30 inversely correlated with all the other QLQ-C30 and QLQ-OG25 symptom scales (r = -0.26 to -0.61; p < 0.05).
  
  
  CONCLUSIONS
  The main HRQoL problems of Polish OC, OGJC and GC patients are fatigue, insomnia, anxiety, and appetite and weight loss. Older age, receiving palliative treatment, having gastric cancer, being on retirement and having lower education are factors associated with higher symptom scores (worse symptoms) and thus poorer HRQoL.
authors.affiliation: Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Krzysztof A
authors.initials: KA
authors.lastname: Tomaszewski
authors.affiliation: Department of Clinical Oncology, University Hospital, Krakow, Poland.
authors.forename: Mirosława
authors.initials: M
authors.lastname: Püsküllüoğlu
authors.affiliation: Department of Internal Medicine, Bonifratres Hospital, Krakow, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Biesiada
authors.affiliation: Department of Clinical Oncology, University Hospital, Krakow, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Bochenek
authors.affiliation: Department of Clinical Oncology, University Hospital, Krakow, Poland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ochenduszko
authors.affiliation: Department of Prosthetic Dentistry, Institute of Dentistry, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Iwona M
authors.initials: IM
authors.lastname: Tomaszewska
authors.affiliation: Department of Clinical Oncology, University Hospital, Krakow, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Krzemieniecki
keywords: QLQ-C30; QLQ-OG25; cancer; oesophago-gastric; oncology; quality of life