title: Assessment of atrial electromechanical delay in patients with polycystic ovary syndrome in both lean and obese subjects.
abstract: OBJECTIVE
  Even though polycystic ovary syndrome (PCOS) is characterized by increased inflammatory activity and insulin resistance, there is no clinical data about whether risk of atrial fibrillation are increased in these patients. We aimed to evaluate atrial conduction parameters predicting atrial involvement in this patient group.
  
  
  METHODS
  The study population comprised 50 women 18-40 years of age who had been diagnosed with PCOS. The patients were divided into two groups: lean women (L-PCOS) with a body mass index (BMI) under 25 kg/m² and obese women (O-PCOS) with a BMI greater than 30 kg/m². Twenty-five age-matched lean healthy women were enrolled voluntarily as the control group. Difference between maximum and minimum P-wave duration was calculated and was defined as P-wave dispersion (Pd). Inter- and intra-atrial electromechanical delays (inter-AED, intra-AED, respectively) were measured with tissue Doppler imaging.
  
  
  RESULTS
  Inter- and intra-AED parameters were higher in the L-PCOS group when compared with control subjects (anova, P=0.004 and P=0.013, respectively), and were also significantly higher in the O-PCOS group compared with other groups (anova, P<0.001 for both). The regression analyses indicated that Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR) (β=0.603, P<0.001) and BMI (β=0.379, P<0.001) were the independent predictors of inter-AED, HOMA-IR (β=0.835, P<0.001) was an independent predictor of intra-AED, and BMI (β=0.457, P=0.006) and the left atrial diameter (β=0.350, P<0.034) were independent predictors of Pd.
  
  
  CONCLUSIONS
  Consequently, our findings provide data regarding prolonged atrial conduction parameters in PCOS patients, especially when accompanied by obesity.
authors.affiliation: Training and Research Hospital, Department of Cardiology, Adiyaman University, Adiyaman, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Taşolar
authors.forename: Türkan
authors.initials: T
authors.lastname: Mete
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ballı
authors.forename: Burak
authors.initials: B
authors.lastname: Altun
authors.forename: Mustafa
authors.initials: M
authors.lastname: Çetin
authors.forename: Tuncay
authors.initials: T
authors.lastname: Yüce
authors.forename: Sevgi
authors.initials: S
authors.lastname: Taşolar
authors.forename: Ömür
authors.initials: Ö
authors.lastname: Otlu
authors.forename: Adil
authors.initials: A
authors.lastname: Bayramoğlu
authors.forename: Hasan
authors.initials: H
authors.lastname: Pekdemir
mesh_terms: D000293:Adolescent; D000328:Adult; D001281:Atrial Fibrillation / Q000453:epidemiology / Q000209:etiology*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D009765:Obesity / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000503:physiopathology*; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
keywords: atrial electromechanical delay; atrial fibrillation; insulin resistance; left ventricular diastolic dysfunction; obesity; polycystic ovary syndrome