title: High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma.
abstract: Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 was associated with poor survival rate and increased recurrence rate of HCC, especially early recurrence, and was an independent prognostic factor for overall survival rate and tumor recurrence. HCC cell lines over-expressing Nova1 exhibited greater potentials in cell proliferation, invasion and migration, while knockdown of Nova1 had the opposite effects. All these findings indicate that Nova1 may act as a prognostic marker for poor outcome and high recurrence in HCC.
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China.
authors.forename: Yi-An
authors.initials: YA
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China.
authors.forename: Ji-Min
authors.initials: JM
authors.lastname: Zhu
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China.
authors.forename: Wen-Qing
authors.initials: WQ
authors.lastname: Tang
authors.affiliation: Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: Guo
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China.
authors.forename: Xi-Zhong
authors.initials: XZ
authors.lastname: Shen
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China; Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Tao-Tao
authors.initials: TT
authors.lastname: Liu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000090682:Neuro-Oncological Ventral Antigen; D011379:Prognosis; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; C000594513:NOVA1 protein, human; D000090682:Neuro-Oncological Ventral Antigen; D034741:RNA, Small Interfering; D016601:RNA-Binding Proteins