title: Serum prolidase enzyme activity and oxidative status in patients with fibromyalgia.
abstract: OBJECTIVE
  This study was performed to investigate serum prolidase enzyme activity and oxidative stress in patients diagnosed with fibromyalgia (FM).
  
  
  METHODS
  The study population consisted of 40 patients with a previous diagnosis of FM and 30 healthy subjects. We measured serum prolidase enzyme activity, total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and paraoxonase-1 (PON-1) levels.
  
  
  RESULTS
  On average, FM patients were diagnosed within 3.2 years of symptom onset, and patients had a mean of 14 tender points. There were no significant differences between patients and controls in age, body mass index, serum TAS, or PON-1 levels. However, patients with FM demonstrated higher serum prolidase activity, TOS, and OSI than the control group. Serum prolidase activity was positively correlated with serum TOS, OSI, and visual analog scale pain and fatigue scores. No correlation was found between serum prolidase activity and FM duration or the average number of tender points.
  
  
  CONCLUSIONS
  Our results demonstrate a previously unreported association between serum prolidase enzyme activity and FM. Increased prolidase activity may contribute to the pathogenesis of FM, and measuring serum prolidase enzyme activity may be a useful FM biomarker.
authors.forename: Mehtap
authors.initials: M
authors.lastname: Bozkurt
authors.forename: Mehmet
authors.initials: M
authors.lastname: Caglayan
authors.forename: Pelin
authors.initials: P
authors.lastname: Oktayoglu
authors.forename: Serda
authors.initials: S
authors.lastname: Em
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Batmaz
authors.forename: Mustafa Akif
authors.initials: MA
authors.lastname: Sariyildiz
authors.forename: Kemal
authors.initials: K
authors.lastname: Nas
authors.forename: Demet
authors.initials: D
authors.lastname: Ucar
authors.forename: Hatice
authors.initials: H
authors.lastname: Yüksel
authors.forename: Aysegul Jale
authors.initials: AJ
authors.lastname: Sarac
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000097:blood; D004150:Dipeptidases / Q000097:blood*; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000201:enzymology*; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D055815:Young Adult
chemical_list: D000975:Antioxidants; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D004150:Dipeptidases; C022449:proline dipeptidase
keywords: Fibromyalgia; Oxidative status; Prolidase