title: Artificial metalloenzymes for enantioselective catalysis.
abstract: Artificial metalloenzymes have emerged over the last decades as an attractive approach towards combining homogeneous catalysis and biocatalysis. A wide variety of catalytic transformations have been established by artificial metalloenzymes, thus establishing proof of concept. The field is now slowly transforming to take on new challenges. These include novel designs, novel catalytic reactions, some of which have no equivalent in both homogenous catalysis and biocatalysis and the incorporation of artificial metalloenzymes in chemoenzymatic cascades. Some of these developments represent promising steps towards integrating artificial metalloenzymes in biological systems. This review will focus on advances in this field and perspectives discussed.
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Bos
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands. Electronic address: j.g.roelfes@rug.nl.
authors.forename: Gerard
authors.initials: G
authors.lastname: Roelfes
mesh_terms: D055162:Biocatalysis; D004247:DNA / Q000378:metabolism; D008667:Metalloproteins / Q000737:chemistry / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D008667:Metalloproteins; D010455:Peptides; D004247:DNA