title: Association between serum total antioxidant status and coronary microvascular function in idiopathic dilated cardiomyopathy.
abstract: BACKGROUND
  Coronary microvascular impairment may cause myocardial ischemia and systolic dysfunction in patients with idiopathic dilated cardiomyopathy (IDC).
  
  
  METHODS
  The study included 41 patients with IDC and 33 healthy control subjects. Serum total antioxidant status (TAS), serum interleukin (IL)-6 levels, and tumor necrosis factor (TNF)-α levels were assayed and coronary flow reserve (CFR) was measured in all subjects via echocardiography.
  
  
  RESULTS
  High-sensitivity C-reactive protein (hsCRP) levels were significantly higher in patients with IDC than in the control group (3.42 ± 2.14 vs. 1.91± 1.40, p = 0.001). Serum TAS was statistically lower in patients with IDC than in controls (1.23 ± 0.16 vs. 1.77 ± 0.12, p < 0.001). CFR was statistically and significantly lower in the IDC group (2.10 ± 0.39 vs. 3.09 ± 0.49, p < 0.001). The IDC group was subsequently subdivided into two groups according to CFR values, as CFR ≥ 2 and CFR < 2. HsCRP (4.30 ± 2.42 vs. 2.58 ± 1.42, p = 0.01), TNF-α (16.67 ± 8.08 vs. 10.97 ± 1.63, p = 0.01), and IL-6 (7.54 ± 6.16 vs. 3.14 ± 1.10, p = 0.05) values were significantly higher in the CFR < 2 group compared with the higher CFR group. TAS (1.3 ± 0.16 vs. 1.14 ± 0.10, p < 0.001) was significantly lower in the CFR < 2 group. CFR correlated significantly with hsCRP, TAS, red cell distribution width (RDW), IL-6, and TNF-α.
  
  
  CONCLUSIONS
  Plasma proinflammatory cytokine levels are increased in patients with IDC. CFR was impaired as a reflection of impaired coronary microvascular dysfunction in association with increasing plasma proinflammatory cytokine levels and hsCRP levels.
authors.affiliation: Department of Cardiology, Baskent University, Konya Teaching and Medical Research Center, Hoca Cihan Mah., Saray Cad., No:1, Selcuklu, Konya, Turkey, caliskandr@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Caliskan
authors.forename: H
authors.initials: H
authors.lastname: Gullu
authors.forename: D
authors.initials: D
authors.lastname: Erdogan
authors.forename: M
authors.initials: M
authors.lastname: Ozulku
authors.forename: S
authors.initials: S
authors.lastname: Kulaksızoglu
authors.forename: O
authors.initials: O
authors.lastname: Ciftci
authors.forename: H
authors.initials: H
authors.lastname: Muderrisoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000150:complications* / Q000175:diagnosis; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications* / Q000175:diagnosis; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D055806:Microvessels / Q000000981:diagnostic imaging; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016207:Cytokines