title: Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial.
abstract: OBJECTIVE
  It has been proposed that royal jelly has antioxidant properties and may improve oxidative stress and glycemic control. Therefore, we investigated the effects of royal jelly supplementation in diabetic females.
  
  
  METHODS
  In this pilot, parallel design randomized clinical trial, 50 female volunteers with type 2 diabetes were randomly allocated to the supplemented (25, cases) and placebo (25, cases) groups, based on random block procedure produced by Random Allocation Software, given a daily dose of 1,000 mg royal jelly soft gel or placebo, respectively, for 8 weeks. Before and after intervention, glycemic control indices, antioxidant and oxidative stress factors were measured.
  
  
  RESULTS
  After royal jelly supplementation, the mean fasting blood glucose decreased remarkably (163.05±42.51 mg/dL vs. 149.68±42.7 mg/dL). Royal jelly supplementation resulted in significant reduction in the mean serum glycosylated hemoglobin levels (8.67%±2.24% vs. 7.05%±1.45%, P=0.001) and significant elevation in the mean insulin concentration (70.28±29.16 pmol/L vs. 86.46±27.50 pmol/L, P=0.01). Supplementation significantly increased erythrocyte superoxidase dismutase and glutathione peroxidase activities and decreased malondialdehyde levels (P<0.05). At the end of study, the mean total antioxidant capacity elevated insignificantly in both groups.
  
  
  CONCLUSIONS
  On the basis of our findings, it seems that royal jelly supplementation may be beneficial in controlling diabetes outcomes. Further studies with larger sample size are warranted.
authors.affiliation: Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Samira
authors.initials: S
authors.lastname: Pourmoradian
authors.forename: Reza
authors.initials: R
authors.lastname: Mahdavi
authors.forename: Majid
authors.initials: M
authors.lastname: Mobasseri
authors.forename: Elnaz
authors.initials: E
authors.lastname: Faramarzi
authors.forename: Mehrnoosh
authors.initials: M
authors.lastname: Mobasseri
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000628:therapy*; D005227:Fatty Acids; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D010865:Pilot Projects; D010919:Placebos; D013482:Superoxide Dismutase / Q000097:blood; D000099219:Royal Jelly
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D005979:Glutathione Peroxidase; D006442:Glycated Hemoglobin; D008315:Malondialdehyde; D010919:Placebos; D013482:Superoxide Dismutase; D000099219:Royal Jelly; C517652:hemoglobin A1c protein, human