title: Dehydroepiandrosterone sulfate and cognition in midlife, post-menopausal women.
abstract: The association between serum dehydroepiandrosterone sulfate (DHEAS) and cognition was assessed in 218 healthy, midlife, post-menopausal women, aged 55-65 years. In cross-sectional analyses, DHEAS level was not significantly associated with a standardized score of global cognition or with individual test scores from a comprehensive neuropsychological battery (all p-values >0.05). In longitudinal analyses of 176 women, DHEAS level was unassociated with cognition 2 years later or with 2-year change in cognition. These findings fail to support the view that DHEAS is substantially related to cognitive function in midlife, post-menopausal women.
authors.affiliation: Department of Medicine, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Charlene K Z
authors.initials: CK
authors.lastname: Chua
authors.affiliation: Department of Health Research and Policy (Epidemiology), Stanford University, Stanford, CA, USA; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
authors.forename: Victor W
authors.initials: VW
authors.lastname: Henderson
authors.affiliation: Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Dennerstein
authors.affiliation: National Ageing Research Institute, Parkville, Victoria, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Ames
authors.affiliation: Department of Medicine, University of Melbourne, Parkville, Victoria, Australia. Electronic address: cszoeke@unimelb.edu.au.
authors.forename: Cassandra
authors.initials: C
authors.lastname: Szoeke
mesh_terms: D000368:Aged; D003071:Cognition; D003430:Cross-Sectional Studies; D003687:Dehydroepiandrosterone / Q000097:blood*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D009483:Neuropsychological Tests; D017698:Postmenopause / Q000097:blood* / Q000523:psychology*; D013997:Time Factors
chemical_list: D003687:Dehydroepiandrosterone
keywords: Cognition; Dehydroepiandrosterone sulfate; Menopause; Midlife; Women