title: Enantioselective N-H insertion reaction of α-aryl α-diazoketones: an efficient route to chiral α-aminoketones.
abstract: A highly enantioselective NH insertion reaction of α-diazoketones was developed by using cooperative catalysis by dirhodium(II) carboxylates and chiral spiro phosphoric acids. The insertion reaction provides a new access route to diverse chiral α-aminoketones, which are versatile building blocks in organic synthesis, with fast reaction rates, good yields and high enantioselectivity under mild and neutral conditions.
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin (China).
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Shou-Fei
authors.initials: SF
authors.lastname: Zhu
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zuo
authors.forename: Zhi-Chao
authors.initials: ZC
authors.lastname: Zhang
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou
keywords: asymmetric catalysis; carbenes; chiral proton shuttle; chiral α-aminoketones; diazo compounds