title: Could HPV-DNA test solve the dilemma about sentinel node frozen section accuracy in early stage cervical cancer? Hypothesis and rationale.
abstract: In order to reduce the surgical invasiveness in early-stage cervical-cancer treatment, the sentinel lymph-node (SLN) technique could be considered as a possible intraoperative-guidance to lymphadenectomy decision making. Unfortunately its accuracy ranges between 33.3% and 100% in different studies. Recent manuscripts suggest that HPV-DNA presence in pelvic-lymph-nodes may represent a molecular marker of micrometastases. According to this hypothesis, the rationale in proposing the HPV-DNA-test when negative frozen-section occurs is due to the expected improvement of its diagnostic-accuracy. HPV-DNA test may represent a marker able to discriminate at frozen section the false-negative from the truth-negative tests filling the gap between optimal and real frozen-section accuracy.
authors.affiliation: Department of Woman and Child Health, University of Padua, Padua, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Noventa
authors.forename: Emanuele
authors.initials: E
authors.lastname: Ancona
authors.forename: Carlo
authors.initials: C
authors.lastname: Saccardi
authors.forename: Pietro
authors.initials: P
authors.lastname: Litta
authors.forename: Donato
authors.initials: D
authors.lastname: D'Antona
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Nardelli
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gizzo
mesh_terms: D004279:DNA, Viral / Q000032:analysis*; D005188:False Negative Reactions; D005260:Female; D005629:Frozen Sections; D006801:Humans; D007430:Intraoperative Care; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery / Q000821:virology; D008207:Lymphatic Metastasis; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000473:pathology*; D010388:Pelvis / Q000821:virology; D021701:Sentinel Lymph Node Biopsy; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D004279:DNA, Viral