title: Outcomes of hypoxic ischaemic encephalopathy treated with therapeutic hypothermia using cool gel packs - experience from Western Australia.
abstract: Therapeutic hypothermia is the standard clinical practice for neonates with moderate to severe hypoxic ischaemic encephalopathy (HIE).
  
  
  OBJECTIVE
  To describe the two year neurodevelopmental outcomes of neonates who were routinely cooled using cool gel packs for HIE in Western Australia.
  
  
  METHODS
  Retrospective study. Cases were identified from the neonatal databases. Information was collected from chart review.
  
  
  RESULTS
  65 infants received therapeutic hypothermia, of which 13 had mild, 35 moderate and 17 had severe HIE. There were no serious adverse effects attributable to cooling. All 13 infants with mild HIE survived, of whom developmental outcomes were available on nine; none had severe disability. Among 52 infants with moderate to severe HIE, there were nine deaths (17%) and developmental outcomes were available on 39; the incidence of severe disability was 23%. The risk of death or severe disability was 40% in infants with moderate to severe HIE. Physical growth was adequate at two years of age.
  
  
  CONCLUSIONS
  Neonates undergoing therapeutic hypothermia with cool gel packs had both good survival rates and long term neurodevelopmental outcomes and met international benchmarks.
authors.affiliation: Department of Neonatology, Princess Margaret Hospital, Perth, Australia.
authors.forename: Jackie
authors.initials: J
authors.lastname: Gardiner
authors.affiliation: Department of Neonatology, Princess Margaret Hospital, Perth, Australia; Centre of Neonatal Research and Education, University of Western Australia, Perth, Australia.
authors.forename: Deepika
authors.initials: D
authors.lastname: Wagh
authors.affiliation: Department of Neonatology, Princess Margaret Hospital, Perth, Australia; State Child Development Centre, West Perth, Australia.
authors.forename: Judy
authors.initials: J
authors.lastname: McMichael
authors.affiliation: Department of Neonatology, Princess Margaret Hospital, Perth, Australia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Hakeem
authors.affiliation: Department of Neonatology, Princess Margaret Hospital, Perth, Australia; Centre of Neonatal Research and Education, University of Western Australia, Perth, Australia. Electronic address: shripada.rao@health.wa.gov.au.
authors.forename: Shripada
authors.initials: S
authors.lastname: Rao
mesh_terms: D001238:Asphyxia Neonatorum / Q000401:mortality / Q000628:therapy*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000517:prevention & control*; D005260:Female; D005782:Gels; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000401:mortality / Q000628:therapy*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D014904:Western Australia
chemical_list: D005782:Gels
keywords: Hypoxic ischaemic encephalopathy; Neurodevelopmental outcomes; Therapeutic hypothermia