title: Systems oncology: towards patient-specific treatment regimes informed by multiscale mathematical modelling.
abstract: The multiscale complexity of cancer as a disease necessitates a corresponding multiscale modelling approach to produce truly predictive mathematical models capable of improving existing treatment protocols. To capture all the dynamics of solid tumour growth and its progression, mathematical modellers need to couple biological processes occurring at various spatial and temporal scales (from genes to tissues). Because effectiveness of cancer therapy is considerably affected by intracellular and extracellular heterogeneities as well as by the dynamical changes in the tissue microenvironment, any model attempt to optimise existing protocols must consider these factors ultimately leading to improved multimodal treatment regimes. By improving existing and building new mathematical models of cancer, modellers can play important role in preventing the use of potentially sub-optimal treatment combinations. In this paper, we analyse a multiscale computational mathematical model for cancer growth and spread, incorporating the multiple effects of radiation therapy and chemotherapy in the patient survival probability and implement the model using two different cell based modelling techniques. We show that the insights provided by such multiscale modelling approaches can ultimately help in designing optimal patient-specific multi-modality treatment protocols that may increase patients quality of life.
authors.affiliation: Division of Mathematics, University of Dundee, Dundee DD1 4HN, UK.
authors.forename: Gibin G
authors.initials: GG
authors.lastname: Powathil
authors.affiliation: The Biocomplexity Institute and Department of Physics, Indiana University Bloomington, Bloomington, IN, USA.
authors.forename: Maciej
authors.initials: M
authors.lastname: Swat
authors.affiliation: Division of Mathematics, University of Dundee, Dundee DD1 4HN, UK. Electronic address: chaplain@maths.dundee.ac.uk.
authors.forename: Mark A J
authors.initials: MA
authors.lastname: Chaplain
mesh_terms: D006801:Humans; D008495:Medical Oncology / Q000379:methods* / Q000639:trends; D008962:Models, Theoretical; D009369:Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy; D049490:Systems Biology / Q000379:methods* / Q000639:trends
keywords: Cell-cycle; Chemotherapy; Hybrid multiscale model; Hypoxia; Radiation therapy