title: Associations between tumor necrosis factor alpha gene polymorphism and sarcoidosis: a meta-analysis.
abstract: Published studies regarding the association between tumor necrosis factor alpha (TNF-α) gene polymorphism and sarcoidosis risk are inconsistent. In order to clarify this association, we performed a meta-analysis of case-control studies with available data. PubMed, EMBASE and BIOSIS Previews were comprehensively searched to identify relevant studies. Twelve case-control studies in 11 articles involving 3,218 participants were included in the meta-analysis to assess the association between TNF-α gene polymorphism and susceptibility to sarcoidosis. We estimated the pooled odds ratio (OR) with its 95% confidence intervals (95% CI) to explore the potential association. Our meta-analysis results suggested that TNF-α-308G/A AA/AG genotype increased sarcoidosis risk, in Asian and Caucasian ethnicity, and in sarcoidosis with Löfgren syndrome. No association was found between TNF-α-238G/A, TNF-α-857C/T polymorphism and sarcoidosis risk. In conclusion, our meta-analysis indicated that AG/GG genotype of TNF-α-308G/A are associated with increased sarcoidosis risk.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou, Guangdong, China.
authors.forename: Hao Jun
authors.initials: HJ
authors.lastname: Xie
authors.forename: Muli
authors.initials: M
authors.lastname: Wu
authors.forename: Yi
authors.initials: Y
authors.lastname: Niu
authors.forename: Bin
authors.initials: B
authors.lastname: Shen
authors.forename: Yating
authors.initials: Y
authors.lastname: Huo
authors.forename: Yuanxiong
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012507:Sarcoidosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People
chemical_list: D014409:Tumor Necrosis Factor-alpha