title: Relationship between serum oncostatin M levels and degree of coronary stenosis in patients with coronary artery disease.
abstract: BACKGROUND
  Oncostatin M (OSM) is an inflammatory cytokine which has been found to be expressed at sites of atherosclerotic lesions. We sought to investigate whether serum OSM levels are associated with coronary stenosis in patients with coronary artery disease (CAD).
  
  
  METHODS
  A total of 117 patients with CAD and 35 patients without CAD who underwent coronary angiography were enrolled in this study. Serum levels of OSM were measured by enzyme-linked immunosorbent assay. The severity of CAD was assessed by the number of diseased vessels and coronary stenosis score.
  
  
  RESULTS
  Serum OSM levels were significantly elevated in CAD patients compared with those without CAD. A stepwise increase in serum levels of OSM was also found depending on the number of > 50% coronary stenosis: median value 4.24 pg/mL (2.72 - 4.24) in 1-vessel disease, 6.44 pg/mL (4.87 - 10.09) in 2-vessel disease, and 7.83 pg/mL (5.41 - 10.37) in 3-vessel disease (p = 0.007 for trend). Correlation analysis showed coronary stenosis score positively correlated with age (r = 0.202, p = 0.029), current smoking (r = 0.210, p = 0.023), hypertension (r = 0.256, p = 0.005), TG (r = 0.408, p = 0.000), LDL-cholesterol (r = 0.325, p < 0.001), and hs-CRP (r = 0.307, p = 0.001), and correlated with OSM (r = 0.314, p < 0.001).
  
  
  CONCLUSIONS
  Our data suggest that increased serum OSM levels are associated with the coronary stenosis score and that circulating levels of this chemokine may reflect the extent of coronary atherosclerosis.
authors.affiliation: Department of Cardiology, Beijing Armed Police Corps Hospital, Beijing 100027, China. lxt_med@163.com
authors.forename: Xiaotao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Science, Beijing 100029, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital, Hebei Medical University, Shijiazhuang Hebei 050031, China.
authors.forename: Liye
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Cardiology, The First Affiliated Hospital, Hebei Medical University, Shijiazhuang Hebei 050031, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Department of Cardiology, Beijing Armed Police Corps Hospital, Beijing 100027, China.
authors.forename: Xichao
authors.initials: X
authors.lastname: Guo
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood*; D023921:Coronary Stenosis / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053683:Oncostatin M / Q000097:blood*
chemical_list: D053683:Oncostatin M