title: Laser perforated accordion nerve conduit of poly(lactide-co-glycolide-co-ɛ-caprolactone).
abstract: Accordion nerve conduit of poly(lactide-co-glycolide-co-ε-caprolactone) with perforations was developed by excimer laser processing. We evaluated its in vivo function for nerve repairing and discussed the influence of pore size and density. It was found that perforations help inner nerve regeneration remarkably, which effect is unrelated to pore size or density, and is not parallel with revascularization increment. Inducing of permeability only to allow substance exchange but not vessel ingrowth could facilitate nerve regeneration too. Perforating micropores with the size of 100 μm and the density of 25/cm provides permeability and vessel ingrowth both, therefore promotes the axon extension the best, larger, and more pores do not advance axon regeneration more.
authors.affiliation: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Shizuko
authors.initials: S
authors.lastname: Ichinose
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Katakura
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Mukai
authors.forename: Kazuo
authors.initials: K
authors.lastname: Takakuda
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D020007:Implants, Experimental; D007834:Lasers; D008297:Male; D008855:Microscopy, Electron, Scanning; D018919:Neovascularization, Physiologic; D009416:Nerve Regeneration; D011091:Polyesters; D016062:Porosity; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000098:blood supply / Q000502:physiology / Q000601:surgery / Q000648:ultrastructure; D054457:Tissue Scaffolds; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C507868:poly(glycolide-co-lactide-co-caprolactone)
keywords: laser processing; nerve conduit; perforation