title: Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057.
abstract: Three new pyrrolobenzodiazepine derivatives, boseongazepines A-C (1-3), were isolated from a culture broth of Streptomyces sp. 11A057, together with the known compound usabamycin B (4). The structures of 1-4 were determined through the analysis of spectroscopic data including extensive 1D-, 2D-NMR, and MS techniques. Cell growth inhibition effects of these compounds were evaluated against Jurkat, K-562, HL-60, and HepG2 cell lines.
authors.affiliation: Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, 217 Gajunro, Yuseong-gu, Daejeon 305-333, Republic of Korea.
authors.forename: Mijin
authors.initials: M
authors.lastname: Oh
authors.affiliation: Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, 217 Gajunro, Yuseong-gu, Daejeon 305-333, Republic of Korea.
authors.forename: Jae-Hyuk
authors.initials: JH
authors.lastname: Jang
authors.affiliation: Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea.
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Choo
authors.affiliation: World Class Institute Center, KRIBB, 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea.
authors.forename: Sun-Ok
authors.initials: SO
authors.lastname: Kim
authors.affiliation: Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea.
authors.forename: Jong Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea.
authors.forename: Sung-Kyun
authors.initials: SK
authors.lastname: Ko
authors.affiliation: World Class Institute Center, KRIBB, 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea.
authors.forename: Nak-Kyun
authors.initials: NK
authors.lastname: Soung
authors.affiliation: Microbial Resources Center, KRIBB, 125 Gwahak-ro, Yuseong-gu, Daejeon 306-809, Republic of Korea.
authors.forename: Jung-Sook
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Microbial Resources Center, KRIBB, 125 Gwahak-ro, Yuseong-gu, Daejeon 306-809, Republic of Korea.
authors.forename: Chang-Jin
authors.initials: CJ
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 570-749, Republic of Korea.
authors.forename: Hyuncheol
authors.initials: H
authors.lastname: Oh
authors.affiliation: Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, 217 Gajunro, Yuseong-gu, Daejeon 305-333, Republic of Korea.
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Hong
authors.affiliation: RIKEN-KRIBB Joint Research Unit, Global Research Cluster, RIKEN, Hirosawa, Wako-shi, Saitama 351-0198, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Ueki
authors.affiliation: RIKEN-KRIBB Joint Research Unit, Global Research Cluster, RIKEN, Hirosawa, Wako-shi, Saitama 351-0198, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirota
authors.affiliation: RIKEN-KRIBB Joint Research Unit, Global Research Cluster, RIKEN, Hirosawa, Wako-shi, Saitama 351-0198, Japan; Chemical Biology Group, RIKEN CSRS, Hirosawa, Wako-shi, Saitama 351-0198, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
authors.affiliation: Department of Biomolecular Science, University of Science and Technology, 217 Gajunro, Yuseong-gu, Daejeon 305-333, Republic of Korea; World Class Institute Center, KRIBB, 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea. Electronic address: bykim@kribb.re.kr.
authors.forename: Bo Yeon
authors.initials: BY
authors.lastname: Kim
authors.affiliation: Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, 217 Gajunro, Yuseong-gu, Daejeon 305-333, Republic of Korea. Electronic address: jsahn@kribb.re.kr.
authors.forename: Jong Seog
authors.initials: JS
authors.lastname: Ahn
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001569:Benzodiazepines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D056945:Hep G2 Cells; D006801:Humans; D019169:Jurkat Cells; D020014:K562 Cells; D008968:Molecular Conformation; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001570:Benzodiazepinones; D011758:Pyrroles; C000596315:boseongazepine C; C438462:pyrrolo(2,1-c)(1,4)benzodiazepine; D001569:Benzodiazepines
keywords: Boseongazepines; Cytotoxicity; Pyrrolobenzodiazepine; Streptomyces