title: Mammary diffuse fibroadenomatoid hyperplasia in water buffalo (Bubalus bubalis): three cases.
abstract: The current report describes 3 rare cases of mammary diffuse fibroadenomatoid hyperplasia in water buffalo (Bubalus bubalis). All of the animals were between 10 and 12 months of age. Grossly, the lesions consisted of severe diffuse swelling with homogeneous large masses in the udder. Surgical removal of the masses was curative. Microscopically, there was severe hyperplasia of the mammary epithelium and numerous well-differentiated and mildly pleomorphic acini and their associated ducts. Moderate proliferation of the fibrous connective tissue and the myoepithelial cells near the proliferating acini was also evident. The hyperplastic epithelial cells exhibited positive immunostaining for cytokeratin, estrogen receptors, and progesterone receptors. In addition, the myoepithelial cells displayed moderate positivity for alpha smooth muscle actin. Based on the clinical, morphologic, and immunohistochemical findings, a diagnosis of mammary diffuse fibroadenomatoid hyperplasia with probable hormonal influence was made.
authors.affiliation: Laboratory of Veterinary Pathology, University of Brasília, Brasília, Distrito Federal, Brazil (de Sant'Ana)Cooperativa Agroindustrial dos Produtores Rurais do Sudoeste Goiano, Santa Helena de Goiás, Goiás, Brazil (Carvalho)Instituto de Ciências Biológicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Gamba, Cassali)Veterinary Hospital, Federal University of Campina Grande, Paraíba, Brazil (Riet-Correa)Regional Laboratory of Diagnosis, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil (Schild) santanafjf@yahoo.com.
authors.forename: Fabiano J F
authors.initials: FJ
authors.lastname: de Sant'Ana
authors.affiliation: Laboratory of Veterinary Pathology, University of Brasília, Brasília, Distrito Federal, Brazil (de Sant'Ana)Cooperativa Agroindustrial dos Produtores Rurais do Sudoeste Goiano, Santa Helena de Goiás, Goiás, Brazil (Carvalho)Instituto de Ciências Biológicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Gamba, Cassali)Veterinary Hospital, Federal University of Campina Grande, Paraíba, Brazil (Riet-Correa)Regional Laboratory of Diagnosis, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil (Schild).
authors.forename: Fausto C
authors.initials: FC
authors.lastname: Carvalho
authors.affiliation: Laboratory of Veterinary Pathology, University of Brasília, Brasília, Distrito Federal, Brazil (de Sant'Ana)Cooperativa Agroindustrial dos Produtores Rurais do Sudoeste Goiano, Santa Helena de Goiás, Goiás, Brazil (Carvalho)Instituto de Ciências Biológicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Gamba, Cassali)Veterinary Hospital, Federal University of Campina Grande, Paraíba, Brazil (Riet-Correa)Regional Laboratory of Diagnosis, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil (Schild).
authors.forename: Conrado
authors.initials: C
authors.lastname: de O Gamba
authors.affiliation: Laboratory of Veterinary Pathology, University of Brasília, Brasília, Distrito Federal, Brazil (de Sant'Ana)Cooperativa Agroindustrial dos Produtores Rurais do Sudoeste Goiano, Santa Helena de Goiás, Goiás, Brazil (Carvalho)Instituto de Ciências Biológicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Gamba, Cassali)Veterinary Hospital, Federal University of Campina Grande, Paraíba, Brazil (Riet-Correa)Regional Laboratory of Diagnosis, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil (Schild).
authors.forename: Geovanni D
authors.initials: GD
authors.lastname: Cassali
authors.affiliation: Laboratory of Veterinary Pathology, University of Brasília, Brasília, Distrito Federal, Brazil (de Sant'Ana)Cooperativa Agroindustrial dos Produtores Rurais do Sudoeste Goiano, Santa Helena de Goiás, Goiás, Brazil (Carvalho)Instituto de Ciências Biológicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Gamba, Cassali)Veterinary Hospital, Federal University of Campina Grande, Paraíba, Brazil (Riet-Correa)Regional Laboratory of Diagnosis, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil (Schild).
authors.forename: Franklin
authors.initials: F
authors.lastname: Riet-Correa
authors.affiliation: Laboratory of Veterinary Pathology, University of Brasília, Brasília, Distrito Federal, Brazil (de Sant'Ana)Cooperativa Agroindustrial dos Produtores Rurais do Sudoeste Goiano, Santa Helena de Goiás, Goiás, Brazil (Carvalho)Instituto de Ciências Biológicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Gamba, Cassali)Veterinary Hospital, Federal University of Campina Grande, Paraíba, Brazil (Riet-Correa)Regional Laboratory of Diagnosis, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil (Schild).
authors.forename: Ana L
authors.initials: AL
authors.lastname: Schild
keywords: Estrogen; mammary hyperplasia; progesterone; water buffalo