title: Ropinirole treatment in Parkinson's disease associated with higher serum level of inflammatory biomarker NT-proCNP.
abstract: There is rapidly growing evidence for the influence of inflammation on the development and progression of Parkinson's disease (PD). N-terminal pro C-type Natriuretic Peptide (NT-proCNP) is a novel potential inflammatory biomarker and has been recently correlated in PD with pro- and anti-inflammatory cytokines, especially TNF-α and IL-10. The study aims to explore serum level of NT-proCNP in group consisted of 132 patients with idiopathic Parkinson's disease (age 59.6±15.l years) and 46 healthy controls (age 58.5±11.5 years). Serum level of NT-proCNP was significantly higher in PD patients than in the control group (p<0.05; PD vs control: mean 3.65±5.5 vs 1.49±0.73, median 1.81 vs 1.46). The serum level of NT-proCNP was directly correlated with the treatment with dopamine agonist (ropinirole) (R=0.38; p<0.05). The higher serum level of NT-proCNP in PD patients being treated with ropinirole suggests a potential proinflammatory characteristic of dopamine agonists.
authors.affiliation: Department of Laboratory Diagnostics, Brodnowski Hospital in Warsaw, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Tomasiuk
authors.affiliation: Department of Neurology, Faculty of Heath Science, Medical University of Warsaw, Poland. Electronic address: stanislaw.szlufik@gmail.com.
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Szlufik
authors.affiliation: Department of Neurology, Faculty of Heath Science, Medical University of Warsaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Friedman
authors.affiliation: Department of Neurology, Faculty of Heath Science, Medical University of Warsaw, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Koziorowski
mesh_terms: D000328:Adult; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018491:Dopamine Agonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D020098:Natriuretic Peptide, C-Type / Q000097:blood*; D010300:Parkinson Disease / Q000097:blood / Q000188:drug therapy*
chemical_list: D000978:Antiparkinson Agents; D015415:Biomarkers; D018491:Dopamine Agonists; D007211:Indoles; C480579:amino-terminal pro-C-type natriuretic peptide, human; C046649:ropinirole; D020098:Natriuretic Peptide, C-Type
keywords: Biomarker; CNP; Dopamine agonist; Inflammatory; Parkinson's disease