title: Negishi coupling: an easy progress for C-C bond construction in total synthesis.
abstract: Negishi cross-coupling reactions were used extensively in total synthesis. The expansion of substrate scope, the development of mild reaction conditions, the advancement of the methods to improve the stereo- and regio-selectivity of carbon-carbon bond formation, the maturity of a large number of sequential processes, and the development of non-toxic reactions signify the importance of Negishi coupling. The following review illustrates a strategic role of this reaction in constructing carbon-carbon bonds in the recent total synthesis of natural products.
authors.affiliation: Department of Chemistry, School of Sciences, Alzahra University, Vanak, Tehran, Iran, mmh1331@yahoo.com.
authors.forename: Majid M
authors.initials: MM
authors.lastname: Heravi
authors.forename: Elaheh
authors.initials: E
authors.lastname: Hashemi
authors.forename: Niousha
authors.initials: N
authors.lastname: Nazari
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D019216:Metals, Heavy / Q000737:chemistry; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D019216:Metals, Heavy; D009930:Organic Chemicals; D002244:Carbon