title: Predictive value of serum myeloperoxidase activity for thrombosis of arteriovenous fistulas.
abstract: Myeloperoxidase is a proinflammatory protein that appears as a result of increased oxidative stress. It plays an important role in the promotion and progression of atherosclerosis. The aim of this study was to determine the importance of MPO as a predictive parameter for thrombosis of arteriovenous fistula (AVF). The study involved monitoring patients with AVFs for hemodialysis over a period of 2 years. There were 41 patients, 19 (46%) men and 22 (54%) women, with mean age of 65 ± 12.7 years. Routine laboratory analyses were carried out in all respondents, including determination of MPO concentration. Gender, demographic and anthropometrical characteristics, smoking, alcohol consumption, as well as the presence of diabetic nephropathy, as an etiological factor of kidney disease, were recorded. The group of patients who developed initial thrombosis of the AVFs had significantly different values for leukocytes (8.5 ± 3.8 vs. 7.3 ± 2.1, P = 0.024), erythrocytes (2.8 ± 0.27 vs. 3.2 ± 0.65; P = 0.019), hemoglobin (88.5 ± 81 vs. 99.1 ± 6.02; P = 0.041), and myeloperoxidase (19.3 ± 4.67 vs. 11.1 ± 4.43; P = 0.007) when compared with the group without fistula thrombosis. Diabetic nephropathy (P = 0.02) characterized the group of patients with thrombosis of the fistula. Diabetic nephropathy (B = 2.53, P = 0.049) and MPO (B = 0.03, P = 0.029) were statistically significant predictors of fistula thrombosis. In our study, MPO and diabetic nephropathy were predictors of thrombosis of the AVF.
authors.affiliation: Internal Clinic, Faculty of Medicine Pristina/Kosovska Mitrovica, University of Pristina, Kosovska Mitrovica, Serbia.
authors.forename: Radojica V
authors.initials: RV
authors.lastname: Stolic
authors.forename: Goran Z
authors.initials: GZ
authors.lastname: Trajkovic
authors.forename: Mirjana
authors.initials: M
authors.lastname: Kostic
authors.forename: Dragica Z
authors.initials: DZ
authors.lastname: Stolic
authors.forename: Dijana J
authors.initials: DJ
authors.lastname: Miric
authors.forename: Bojana M
authors.initials: BM
authors.lastname: Kisic
authors.forename: Slavica D
authors.initials: SD
authors.lastname: Pajovic
authors.forename: Vladan M
authors.initials: VM
authors.lastname: Peric
mesh_terms: D000368:Aged; D001164:Arteriovenous Fistula / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D009195:Peroxidase / Q000097:blood*; D011237:Predictive Value of Tests; D006435:Renal Dialysis / Q000009:adverse effects*; D013927:Thrombosis / Q000097:blood*
chemical_list: D009195:Peroxidase
keywords: Oxidative stress; arteriovenous fistula; atherosclerosis; hemodialysis; myeloperoxidase; thrombosis