title: The AIDS epidemic in the Amazon region: a spatial case-control study in Rondonia, Brazil.
abstract: OBJECTIVE
  To analyze spatial changes in the risk of AIDS and the relationship between AIDS incidence and socioeconomic variables in the state of Rondonia, Amazon region.
  
  
  METHODS
  A spatial, population case-control study in Rondonia, Brazil, based on 1,780 cases reported to the Epidemiological Surveillance System and controls based on demographic data from 1987 to 2006. The cases were grouped into five consecutive four-year periods. A generalized additive model was adjusted to the data; the dependent variable was the status of the individuals (case or control), and the independent variables were a bi-dimensional spline of the geographic coordinates and some municipality-level socioeconomic variables. The observed values of the Moran's I test were compared to a reference distribution of values generated under conditions of spatial randomness.
  
  
  RESULTS
  AIDS risk shows a marked spatial and temporal pattern. The disease incidence is related to socioeconomic variables at the municipal level in Rondônia, such as urbanization and human capital. The highest incidence rates of AIDS are in municipalities along the BR-364 highway and calculations of the Moran's I test show positive spatial correlation associated with proximity of the municipality to the highway in the third and fourth periods (p = 0.05).
  
  
  CONCLUSIONS
  Incidence of the disease is higher in municipalities of greater economic wealth and urbanization, and in those municipalities bisected by Rondônia's main roads. The rapid development associated with the opening up of once remote regions may be accompanied by an increase in these risks to health.
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Donalisio
authors.forename: Ricardo
authors.initials: R
authors.lastname: Cordeiro
authors.forename: Roberto Wagner
authors.initials: RW
authors.lastname: Lourenco
authors.forename: J Christopher
authors.initials: JC
authors.lastname: Brown
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology*; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D058872:Epidemics; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D017678:Sex Distribution; D012959:Socioeconomic Factors; D013029:Space-Time Clustering