title: In-depth analysis of local recurrence of giant cell tumour of bone with soft tissue extension after intralesional curettage.
abstract: OBJECTIVE
  The aim of this study was to assess the local recurrence rate of giant cell tumour of bone (GCTB) with soft tissue extension, to identify characteristics of the soft tissue extension that can best indicate recurrence of GCTB after intralesional curettage.
  
  
  METHODS
  A total of 48 cases of GCTB with soft tissue extension after intralesional curettage were recruited. Patients were divided into two groups based on various objective features of soft tissue extension including size, number, margins, involvement of adjacent tissues, signal intensity, static enhancement and Jaffe grade. The local recurrence rate was compared using the Chi-square test and Chi-square value correction for continuity. Risk factors were assessed by multivariate logistic regression analysis.
  
  
  RESULTS
  The local recurrence rate was significantly different according to soft tissue extension size, number and margins (p < 0.05). There was no significant difference in the groups of adjacent tissue involvement and Jaffe grade (p > 0.05). Size, number and margins of the soft tissue extension were independent risk factors of local recurrence of GCTB after intralesional curettage (p < 0.05).
  
  
  CONCLUSIONS
  The local recurrence rate of GCTB with soft tissue extension after intralesional curettage is higher if the soft tissue extension is large, multiple and lacking bone envelope integrity. For cases with the above-mentioned features, we suggest that the higher recurrence rate can be taken into full consideration when choosing appropriate surgical procedures.
authors.affiliation: Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin 2nd Road, Shanghai, 200025, China, chenliang0106@yahoo.com.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Ding
authors.forename: Chengs-Sheng
authors.initials: CS
authors.lastname: Wang
authors.forename: Ming-Jue
authors.initials: MJ
authors.lastname: Si
authors.forename: Lian-Jun
authors.initials: LJ
authors.lastname: Du
authors.forename: Wei-Bin
authors.initials: WB
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology* / Q000601:surgery*; D003475:Curettage / Q000379:methods; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D055815:Young Adult