title: Catalytic asymmetric exo-selective [C+NC+CC] reaction.
abstract: A catalytic asymmetric version of the exo-selective [C+NC+CC] reaction is reported. This multicomponent reaction utilizes a readily prepared achiral glycyl sultam as the "NC" component and commercially available catalyst components. The method can be applied to a variety of aldehydes ("C" component) and activated alkenes ("CC" component) to provide substituted pyrrolidines in good yields and high enantioselectivities. Of particular note is the ability to employ labile enolizable aldehydes (e.g., acetaldehyde and propionaldehyde) in this reaction.
authors.affiliation: Department of Chemistry, Washington State University , Pullman, Washington 99164-4630, United States.
authors.forename: Ryan
authors.initials: R
authors.lastname: Joseph
authors.forename: Charles
authors.initials: C
authors.lastname: Murray
authors.forename: Philip
authors.initials: P
authors.lastname: Garner
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000475:Alkenes; D011759:Pyrrolidines; C005556:propionaldehyde