title: More than just a filler - the role of hyaluronan for skin homeostasis.
abstract: In recent years, hyaluronan (HA) has become an increasingly attractive substance as a non-immunogenic filler and scaffolding material in cosmetic dermatology. Despite its wide use for skin augmentation and rejuvenation, relatively little is known about the molecular structures and interacting proteins of HA in normal and diseased skin. However, a comprehensive understanding of cutaneous HA homeostasis is required for future the development of HA-based applications for skin regeneration. This review provides an update on HA-based structures, expression, metabolism and its regulation, function and pharmacological targeting of HA in skin.
authors.affiliation: Department of Dermatology, Venerology and Allergology, University of Leipzig, Leipzig, Germany.
authors.forename: Ulf
authors.initials: U
authors.lastname: Anderegg
authors.forename: Jan C
authors.initials: JC
authors.lastname: Simon
authors.forename: Marco
authors.initials: M
authors.lastname: Averbeck
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003358:Cosmetics / Q000737:chemistry; D003880:Dermatology; D005145:Face; D006706:Homeostasis; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D006820:Hyaluronic Acid / Q000737:chemistry / Q000502:physiology*; D008024:Ligands; D012038:Regeneration; D015398:Signal Transduction; D012867:Skin; D015595:Skin Aging; D012879:Skin Physiological Phenomena
chemical_list: D001672:Biocompatible Materials; D003358:Cosmetics; D018960:Hyaluronan Receptors; D008024:Ligands; D006820:Hyaluronic Acid
keywords: fillers; hyaluronan; metabolism; skin; skin regeneration