title: Association between polymorphisms in lysyl oxidase-like 1 and susceptibility to pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
abstract: The present knowledge on the association of single nucleotide polymorphisms (SNPs) of lysyl oxidase-like 1 (LOXL1) with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG) is controversial and inconclusive. This meta-analysis sought to derive a more precise estimation of the effects of LOXL1 SNP loci (rs1048661, rs3825942, and rs2165241) on PEXS/PEXG. Literature searches were conducted on the PubMed, EMBASE, ISI Web of Science, and Cochrane Library databases through October 2013. Twelve studies describing 1810 cases and 1790 controls met the inclusion criteria. The strengths of the associations found through the meta-analysis were assessed with pooled odds ratios and their 95% confidence intervals (CI). A meta-regression analysis was also used to examine the influence of the study and population characteristics. The results indicated that rs1048661 TT carriers had 92.1% and 40.4% less risk of developing PEXS/PEXG than did the controls in the Caucasian and Asian populations, respectively. Carriers of rs3825942 AA or rs2165241 CC also had significantly less PEXS/PEXG susceptibility than did the non-carriers. Meta-regression showed that in Caucasians, the male proportion (slope: 0.272; 95% CI: 0.167-0.376; P = 0.0001) and mean age (slope: 0.796; 95% CI: 0.375-1.217; P = 0.0002) of the PEXS/PEXG subjects correlated positively with the effect of rs3825942 on PEXS/PEXG susceptibility. The meta-analysis suggested that LOXL1 rs1048661 TT, rs3825942 AA, and rs2165241 CC were associated with a reduced risk of developing PEXS/PEXG.
authors.affiliation: Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Jun-Zhou
authors.initials: JZ
authors.lastname: Tang
authors.affiliation: Department of Ophthalmology, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, China.
authors.forename: Xiu-Qing
authors.initials: XQ
authors.lastname: Wang
authors.forename: Hua-Feng
authors.initials: HF
authors.lastname: Ma
authors.affiliation: Department of Ophthalmology, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, China.
authors.forename: Fa-Feng
authors.initials: FF
authors.lastname: Ma
authors.affiliation: Department of Endocrinology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, P.R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Emergency, Second Affiliated Hospital, Chongqing Medical University, Chongqing, P.R. China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, China.
authors.forename: Zhi-Xi
authors.initials: ZX
authors.lastname: Peng
authors.affiliation: Department of Ophthalmology, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, China.
authors.forename: Xi-Yuan
authors.initials: XY
authors.lastname: Zhou
mesh_terms: D000367:Age Factors; D000368:Aged; D000483:Alleles; D000594:Amino Acid Oxidoreductases / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D017889:Exfoliation Syndrome / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012737:Sex Factors; D044465:White People / Q000235:genetics
chemical_list: D000594:Amino Acid Oxidoreductases; C445313:LOXL1 protein, human