title: [Use of erythropoiesis stimulating agents].
abstract: Anemia is fairly common in lung neoplasms and adequate management can influence both the prognosis and the quality of life of patients. Anemia can stem from diverse mechanisms, and its management must include the search for correctable causes (iron deficiency, inflammation, disease- or treatment-related), and their subsequent treatment. Use of erythropoiesis stimulating agents, namely recombinant erythropoietin, results in hemoglobin increase, fewer blood transfusions, and better quality of life. However, there is also a significant increase in thromboembolic risk associated with this treatment, and their effect on overall survival is still debated. Thus, their use must be restricted to patients treated with palliative intent, receiving chemotherapy but no radiotherapy, with a baseline hemoglobin level under 100 g/L, and target hemoglobin level must not exceed 120 g/L.
authors.affiliation: Service de pneumologie et oncologie thoracique, hospices civils de Lyon, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Lapierre
authors.affiliation: Service de pneumologie et oncologie thoracique, hospices civils de Lyon, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France. Electronic address: pierre-jean.souquet@chu-lyon.fr.
authors.forename: P-J
authors.initials: PJ
authors.lastname: Souquet
mesh_terms: D000740:Anemia / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D004921:Erythropoietin / Q000627:therapeutic use; D006397:Hematinics / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology; D017410:Practice Guidelines as Topic
chemical_list: D006397:Hematinics; D004921:Erythropoietin
keywords: Anemia; Anémie; Cancer bronchique; Erythropoietin; Lung cancer; Quality of life; Qualité de vie; Érythropoïétine