title: [Anti-Müllerian hormone serum levels in women with and without uterine fibroids].
abstract: BACKGROUND
  The etiology of uterine leiomyomatosis is multifactorial and it is unknown if a relation between anti-Müllerian hormone (hormona anti-mülleriana) and uterine leiomyomatosis exists.
  
  
  OBJECTIVE
  To determine the differences of hormona anti-mülleriana levels in women with and without uterine leiomyomatosis.
  
  
  METHODS
  60 women were studied (30 with and 30 without uterine leiomyomatosis). The diagnosis was confirmed by histopathology. Both groups were paired by age and in all them serum levels of hormona antimülleriana were measured using ELISA, also estradiol and progesterone serum levels were determined. hormona anti-mülleriana-RII immunohistochemistry was done in healthy myometrium and in leiomyomas.
  
  
  RESULTS
  The mean age between the groups didn't show statistical difference (41.8 +/- 5.6 years vs. 41.4 +/- 5.7 years). Also no differences were found in weight, height and body mass index. Serum levels of hormona antimülleriana were lower in those with leiomyomatosis [0.21 (0-10.4) ng/ml vs. 1.83 (0-6.38) ng/ml, p < 0.005]. No statistical differences were found in estradiol and progesterone serum levels between the groups. The hormona antimülleriana receptor was no expressed neither in the healthy myometrium nor in the leiomyomas.
  
  
  CONCLUSIONS
  Women with leiomyomatosis had lower hormona antimülleriana levels. More studies are needed to determine if a relation exists between hormona antimülleriana and uterine leiomyomas.
authors.forename: Sebastián
authors.initials: S
authors.lastname: Carranza-Lira
authors.forename: Jenifer Alejandra
authors.initials: JA
authors.lastname: Bustamante-Mendoza
authors.forename: Alfredo
authors.initials: A
authors.lastname: Leaños-Miranda
authors.forename: Inova
authors.initials: I
authors.lastname: Campos-Galicia
authors.forename: Isaías
authors.initials: I
authors.lastname: Estrada-Moscoso
authors.forename: Rosario
authors.initials: R
authors.lastname: Chan-Verdugo
authors.forename: María del Pilar
authors.initials: Mdel P
authors.lastname: Ramos-Godínez
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Moncada-Claudio
authors.forename: Maria de Lourdes
authors.initials: Mde L
authors.lastname: Peña-Torres
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000097:blood* / Q000473:pathology; D008875:Middle Aged; D011374:Progesterone / Q000097:blood; D018000:Receptors, Peptide / Q000378:metabolism; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D014594:Uterine Neoplasms / Q000097:blood* / Q000473:pathology
chemical_list: D018000:Receptors, Peptide; D018125:Receptors, Transforming Growth Factor beta; C084621:anti-Mullerian hormone receptor; D011374:Progesterone; D004958:Estradiol; D054304:Anti-Mullerian Hormone