title: [Properties and clinical implications of middle molecular weight low substitution hydroxyethyl starch solution].
abstract: In this review article, the properties and clinical implications of middle molecular weight low substitution hydroxyethyl starch (HES) solution are summarized. This preparation shows larger volume effect and longer duration compared to the currently available low-molecular weight HES solution and will be available in the near future in Japan. Effects on renal function and coagulation system are supposedly dependent on the persistence of larger HES molecule in the body and this middle molecular weight low substitution HES preparation may be advantageous to the older HES preparation due to its rapid metabolism. This preparation has been successfully used in the goal-directed fluid management in the early recovery program after surgery and will offer several advantages in fluid management when introduced in Japan.
authors.affiliation: Department ofAnesthesiology, Toho University Ohashi Medical Center, Tokyo 153-8515.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kotake
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D001777:Blood Coagulation / Q000187:drug effects; D003102:Colloids; D003362:Cost-Benefit Analysis; D005440:Fluid Therapy; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D007564:Japan; D007668:Kidney / Q000378:metabolism; D050866:Liquid Crystals; D008970:Molecular Weight; D051381:Rats; D012996:Solutions
chemical_list: D000893:Anti-Inflammatory Agents; D003102:Colloids; D006895:Hydroxyethyl Starch Derivatives; D012996:Solutions