title: Vitamin B12 deficiency with intrinsic factor antibodies in an infant with poor growth and developmental delay.
abstract: Vitamin B12 deficiency is very rare in infants and may lead to serious hematological and neurodevelopmental abnormalities. The present article describes a case involving a seven-month-old boy with severe vitamin B12 deficiency, likely caused by juvenile pernicious anemia, an entity rarely described. The child presented with feeding intolerance, poor growth and developmental delay. He was noted to have macrocytic anemia, a markedly low serum vitamin B12 level, and elevated homocysteine and methylmalonic acid levels. Antibodies to intrinsic factor were positive. The mother was healthy, with normal vitamin B12 status. Therapy with vitamin B12 supplements led to excellent recovery of symptoms. Vitamin B12 deficiency should be considered in children presenting with failure to thrive, especially when compounded with neurological symptoms. Early diagnosis and adequate treatment is essential to avoid serious complications.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, Dalhousie University, IWK Health Center, Halifax, Nova Scotia.
authors.forename: Kathleen
authors.initials: K
authors.lastname: McNeil
authors.affiliation: Department of Paediatrics, Faculty of Medicine, Dalhousie University, IWK Health Center, Halifax, Nova Scotia.
authors.forename: Dhiman
authors.initials: D
authors.lastname: Chowdhury
authors.affiliation: Department of Paediatrics, Faculty of Medicine, Dalhousie University, IWK Health Center, Halifax, Nova Scotia.
authors.forename: Lynette
authors.initials: L
authors.lastname: Penney
authors.affiliation: Department of Paediatrics, Faculty of Medicine, Dalhousie University, IWK Health Center, Halifax, Nova Scotia.
authors.forename: Mohsin
authors.initials: M
authors.lastname: Rashid
keywords: Developmental delay; Infant; Megaloblastic anemia; Vitamin B12 deficiency