title: Immune and genetic gardening of the intestinal microbiome.
abstract: The mucosal immune system - consisting of adaptive and innate immune cells as well as the epithelium - is profoundly influenced by its microbial environment. There is now growing evidence that the converse is also true, that the immune system shapes the composition of the intestinal microbiome. During conditions of health, this bidirectional interaction achieves a homeostasis in which inappropriate immune responses to non-pathogenic microbes are averted and immune activity suppresses blooms of potentially pathogenic microbes (pathobionts). Genetic alteration in immune/epithelial function can affect host gardening of the intestinal microbiome, contributing to the diversity of intestinal microbiota within a population and in some cases allowing for unfavorable microbial ecologies (dysbiosis) that confer disease susceptibility.
authors.affiliation: Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Jacobs
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: jbraun@mednet.ucla.edu.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Braun
mesh_terms: D000818:Animals; D014644:Genetic Variation; D006801:Humans; D007109:Immunity; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D007422:Intestines / Q000276:immunology / Q000382:microbiology*; D064307:Microbiota; D051192:Receptors, Pattern Recognition / Q000378:metabolism
chemical_list: D051192:Receptors, Pattern Recognition
keywords: Crohn’s disease; Epithelium; Immune system; Inflammatory bowel disease; Innate lymphoid cell; Intestine; Microbial ecology; Microbiome; Mucosal immunology; Pattern recognition receptor; Ulcerative colitis