title: Use of tenecteplase in recurrent prosthetic valve thrombosis.
abstract: Prosthetic valve thrombosis (PVT) is a serious complication of mechanical prosthetic heart valves, the available treatment options for which are either thrombolytic therapy or surgery. In patients who have already received streptokinase to treat a previous episode of PVT, the therapeutic options are limited. Herein, the case is reported of an elderly female patient with a second episode of PVT treated successfully with tenecteplase.
authors.affiliation: Department of Cardiology, UIsha Mullapudi Cardiac Center, Hyderabad, India. vhariram@hotmail.com
authors.forename: Vuppaladadhiam
authors.initials: V
authors.lastname: Hariram
authors.affiliation: Department of CIinical Research, UIsha Mullapudi Cardiac Center, Hyderabad, India.
authors.forename: Nuthi Prashanthi
authors.initials: NP
authors.lastname: Sharma
mesh_terms: D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation*; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D011474:Prosthesis Design; D020127:Recovery of Function; D012008:Recurrence; D000077785:Tenecteplase; D013927:Thrombosis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator; D000077785:Tenecteplase