title: 5-HT6 receptor antagonists as treatment for age-related cognitive decline.
abstract: The 5-HT6 receptor (5-HT6R) is one of the most recently discovered serotonin receptors and has received much attention after observations showing its procognition properties. Indeed, 5-HT6R appears to be a promising target to treat cognitive decline, particularly via its modulatory function of cholinergic and glutamatergic systems. 5-HT6Rs are present mostly in the central nervous system, in brain structures known to be particularly involved in memory. Growing evidence suggests that blockade of 5-HT6R can not only improve memory processes in adult rodents but also reverse age-related and pharmacologically induced deficits. 5-HT6R blockade could also have a beneficial effect on neuronal plasticity. Regarding these findings, several 5-HT6R antagonists are currently going through clinical trials. This review provides an overview of the major findings arguing in favour of a role for 5-HT6R antagonists in developing treatment for cognitive disorders related to ageing and neurodegenerative diseases.
authors.forename: Anne
authors.initials: A
authors.lastname: Quiedeville
authors.forename: Michel
authors.initials: M
authors.lastname: Boulouard
authors.forename: Virginie
authors.initials: V
authors.lastname: Da Silva Costa-Aze
authors.forename: François
authors.initials: F
authors.lastname: Dauphin
authors.forename: Valentine
authors.initials: V
authors.lastname: Bouet
authors.forename: Thomas
authors.initials: T
authors.lastname: Freret
mesh_terms: D000375:Aging; D000818:Animals; D003072:Cognition Disorders / Q000188:drug therapy*; D006801:Humans; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000627:therapeutic use*
chemical_list: D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C097216:serotonin 6 receptor