title: The role of targeted protein degradation in early neural development.
abstract: As neural stem cells differentiate into neurons during neurogenesis, the proteome of the cells is restructured by de novo expression and selective removal of regulatory proteins. The control of neurogenesis at the level of gene regulation is well documented and the regulation of protein abundance through protein degradation via the Ubiquitin/26S proteasome pathway is a rapidly developing field. This review describes our current understanding of the role of the proteasome pathway in neurogenesis. Collectively, the studies show that targeted protein degradation is an important regulatory mechanism in the generation of new neurons.
authors.affiliation: Department of Biology, Georgetown University, Washington, DC.
authors.forename: Banu
authors.initials: B
authors.lastname: Saritas-Yildirim
authors.forename: Elena M
authors.initials: EM
authors.lastname: Silva
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009420:Nervous System / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D055495:Neurogenesis; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D059748:Proteolysis; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000502:physiology; D057149:Ubiquitinated Proteins / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D057149:Ubiquitinated Proteins; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex
keywords: F-box proteins; neural induction; neurogenesis; ubiquitin ligase