title: Differential implication of dorsolateral and dorsomedial srtiatum in encoding and recovery processes of latent inhibition.
abstract: The dorsal striatum has been ascribed to different behavioral roles. While the lateral area (dls) is implicated in habitual actions, its medial part (dms) is linked to goal expectancy. According to this model, dls function includes representation of stimulus-response associations, but not of goals. Dls function has been typically analyzed with regard to movement, and there is no data indicating whether this region could processes specific stimulus-outcome associations. To test this possibility, we analyzed the effects of dls and dms inactivation on the retrieval phase, and dms lesion on the acquisition phase of a latent inhibition procedure using two conditions, long and short presentations of the future conditioned stimulus. Contrary to current theories of basal ganglia function, we report evidence in favor of the dls involvement in cognitive processes of learning and retrieval. Moreover, we provide data about the sequential relationship between dms and dls, in which the dms could be involved, but it would not be critical, in new learning and the dls could be subsequently involved in consolidating cognitive routines.
authors.affiliation: Animal Behavior and Neuroscience Lab, Dpt. Psicología Experimental, Universidad de Sevilla, c/Camilo Jose Cela s/n, 41018 Seville, Spain.
authors.forename: Estrella
authors.initials: E
authors.lastname: Díaz
authors.affiliation: Animal Behavior and Neuroscience Lab, Dpt. Psicología Experimental, Universidad de Sevilla, c/Camilo Jose Cela s/n, 41018 Seville, Spain.
authors.forename: Juan Pedro
authors.initials: JP
authors.lastname: Vargas
authors.affiliation: Animal Behavior and Neuroscience Lab, Dpt. Psicología Experimental, Universidad de Sevilla, c/Camilo Jose Cela s/n, 41018 Seville, Spain.
authors.forename: Esperanza
authors.initials: E
authors.lastname: Quintero
authors.affiliation: Animal Behavior and Neuroscience Lab, Dpt. Psicología Experimental, Universidad de Sevilla, c/Camilo Jose Cela s/n, 41018 Seville, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Gonzalo de la Casa
authors.affiliation: Dpt. of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, United States.
authors.forename: Patricio
authors.initials: P
authors.lastname: O'Donnell
authors.affiliation: Animal Behavior and Neuroscience Lab, Dpt. Psicología Experimental, Universidad de Sevilla, c/Camilo Jose Cela s/n, 41018 Seville, Spain. Electronic address: jclopez@us.es.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Lopez
mesh_terms: D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology*; D007266:Inhibition, Psychological; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D017208:Rats, Wistar
keywords: Dorso-lateral striatum; Dorso-media striatum; Latent inhibition; Retrieval processes