title: Bifunctional ferrocene-based squaramide-phosphine as an organocatalyst for highly enantioselective intramolecular Morita-Baylis-Hillman reaction.
abstract: This work demonstrates that, in accord with metal catalysis, ferrocene could be an excellent scaffold for organocatalysts. The simple and easily accessible bifunctional ferrocene-based squaramide-phosphine shows high enantioselectivity in the intramolecular Morita-Baylis-Hillman reaction of 7-aryl-7-oxo-5-heptenals, giving a variety of 2-aroyl-2-cyclohexenols in up to 96% ee.
authors.affiliation: School of Pharmacy, Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, P. R. China. wpchen@fmmu.edu.cn.
authors.forename: Xiaorui
authors.initials: X
authors.lastname: Zhang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Ma
authors.forename: Dongxu
authors.initials: D
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Lei
authors.forename: Shengyong
authors.initials: S
authors.lastname: Zhang
authors.forename: Ru
authors.initials: R
authors.lastname: Jiang
authors.forename: Weiping
authors.initials: W
authors.lastname: Chen
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D005296:Ferrous Compounds / Q000737:chemistry*; D000075163:Metallocenes; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000577:Amides; D005296:Ferrous Compounds; D000075163:Metallocenes; D010720:Phosphines; C044646:phosphine; C004998:ferrocene