title: Effect of acute and chronic administration of carbamazepine on Cisplatin-induced hyperalgesia in rats.
abstract: BACKGROUND
  Cisplatin is an effective antineoplastic drug used extensively in the treatment of malignancies. It induces painful peripheral neuropathy at high doses.
  
  
  OBJECTIVE
  The aim of this study was to investigate the effect of carbamazepine (CBZ) on cisplatin-induced peripheral neuropathic pain by using the tail-flick test.
  
  
  METHODS
  The study was performed using male Wistar rats weighing 180-200 g. Neuropathic pain was induced by intraperitoneal (IP) administration of cisplatin (5 mg/kg). The effect of oral (PO) CBZ administration (5, 10, and 15 mg/kg) on cisplatin-induced pain was assessed using the tail-flick test.
  
  
  RESULTS
  Our results showed that cisplatin (5 mg/kg, IP) induced egregious pain (P < 0.01) on day 15. Acute administration of CBZ (5, 10, and 15 mg/kg, PO) caused significant (P < 0.05) increase in tail-flick time latency in a dose-dependent manner, in comparison with that observed in the control group. Furthermore, chronic administration of CBZ (5, 10, and 15 mg/kg, PO) increased (P < 0.05) the pain threshold on days 5 and 10. The analgesic effect of morphine (5 mg/kg, IP) was greater than that after acute CBZ administration (5, 10, and 15 mg/kg, PO).
  
  
  CONCLUSIONS
  Our results showed that both acute and chronic CBZ administration attenuated cisplatin-induced pain. We suggest that CBZ can be used clinically for alleviating cisplatin-induced neuropathic pain in cancer patients, without any limitations such as tolerance to analgesic effect.
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran ; Department of Pharmacology and Toxicology, Fcaulty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mohajjel Nayebi
authors.affiliation: Department of Pharmacology and Toxicology, Fcaulty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors.forename: Hamdollah
authors.initials: H
authors.lastname: Sharifi
authors.affiliation: Department of Pharmacology and Toxicology, Fcaulty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ramadzani
authors.affiliation: Department of Pharmacology and Toxicology, Fcaulty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Rezazadeh
keywords: Carbamazepine; Cisplatin; Neuralgia