title: Flow injection chemiluminescence determination of lercanidipine based on N-chlorosuccinimide-eosin Y post-chemiluminescence reaction.
abstract: A novel post-chemiluminescence (PCL) reaction was discovered when lercanidipine was injected into the CL reaction mixture of N-chlorosuccinimide with alkaline eosin Y in the presence of cetyltrimethylammonium bromide (CTAB), where eosin Y was used as the CL reagent and CTAB as the surfactant. Based on this observation, a simple and highly sensitive PCL method combined with a flow injection (FI) technique was developed for the assay of lercanidipine. Under optimum conditions, the CL signal was linearly related to the concentration of lercanidipine in the range 7.0 × 10(-10) to 3.0 × 10(-6)  g/mL with a detection limit of 2.3 × 10(-10) g/mL (3σ). The relative standard deviation (RSD) was 2.1% for 1.0 × 10(-8) g/mL lercanidipine (n = 13). The proposed method had been applied to the estimation of lercanidipine in tablets and human serum samples with satisfactory results. The possible CL mechanism is also discussed briefly.
authors.affiliation: Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region, Engineering Center for Chemical Materials of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang, 832003, People's Republic of China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Zhao
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000284:Administration, Oral; D016477:Artifacts; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D004095:Dihydropyridines / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D004801:Eosine Yellowish-(YS) / Q000737:chemistry*; D017022:Flow Injection Analysis / Q000379:methods; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D057230:Limit of Detection; D008163:Luminescent Measurements / Q000379:methods*; D012972:Sodium Hydroxide / Q000737:chemistry; D013388:Succinimides / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry; D013607:Tablets / Q000032:analysis
chemical_list: D002593:Cetrimonium Compounds; D004095:Dihydropyridines; D005456:Fluorescent Dyes; D013388:Succinimides; D013501:Surface-Active Agents; D013607:Tablets; C015752:N-chlorosuccinimide; D012972:Sodium Hydroxide; D004801:Eosine Yellowish-(YS); C060343:lercanidipine; D000077286:Cetrimonium
keywords: N-chlorosuccinimide; eosin Y; flow injection; lercanidipine; post chemiluminescence