title: The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids.
abstract: Malaria is currently a public health concern in many countries in the world due to various factors which are not yet under check. Drug discovery projects targeting malaria often resort to natural sources in the search for lead compounds. A survey of the literature has led to a summary of the major findings regarding plant-derived compounds from African flora, which have shown anti-malarial/antiplasmodial activities, tested by in vitro and in vivo assays. Considerations have been given to compounds with activities ranging from "very active" to "weakly active", leading to >500 chemical structures, mainly alkaloids, terpenoids, flavonoids, coumarins, phenolics, polyacetylenes, xanthones, quinones, steroids and lignans. However, only the compounds that showed anti-malarial activity, from "very active" to "moderately active", are discussed in this review.
authors.forename: Fidele
authors.initials: F
authors.lastname: Ntie-Kang
authors.forename: Pascal Amoa
authors.initials: PA
authors.lastname: Onguéné
authors.forename: Lydia L
authors.initials: LL
authors.lastname: Lifongo
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Ndom
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sippl
authors.affiliation: Department of Chemistry, Faculty of Science, University of Douala, PO Box 24157, Douala, Cameroon. lmbazze@yahoo.fr.
authors.forename: Luc Meva'a
authors.initials: LM
authors.lastname: Mbaze
mesh_terms: D000349:Africa; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000962:Antimalarials