title: [Resistance to warfarin in a patient with hereditary thrombophilia].
abstract: We present a case report of a young man with spontaneous deep venous thrombosis. He tested positive for heterozygote factor V Leiden mutation and was treated with warfarin. However, he turned out to be resistant to warfarin, and another venous thrombosis occurred during the insufficient treatment. The antithrombotic treatment was then successfully replaced by phenprocoumon. This case report emphasizes the importance of critically evaluating the efficacy of a treatment and substitute if proven insufficient.
authors.affiliation: J.B. Winsløws Vej 9A, 5000 Odense C. phaastrup@health.sdu.dk.
authors.forename: Peter
authors.initials: P
authors.lastname: Haastrup
authors.forename: Torsten
authors.initials: T
authors.lastname: Rudbæk
authors.forename: Jeppe
authors.initials: J
authors.lastname: Bove
mesh_terms: D020016:Activated Protein C Resistance / Q000151:congenital* / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008661:Metabolism, Inborn Errors / Q000235:genetics / Q000378:metabolism; D019851:Thrombophilia / Q000151:congenital* / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D020246:Venous Thrombosis / Q000139:chemically induced; D014859:Warfarin / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin