title: Past and current hepatitis E virus infection in renal transplant patients.
abstract: The chronic course of hepatitis E virus infection in immunosuppressed patients has been recently documented; however, clinical features and factors associated with this occurrence are not well known. The aim of this study was to evaluate the prevalence of previous or current HEV infection in renal transplant patients. One hundred ninety-two kidney transplant patients were studied and classified in three groups: G1-infected with hepatitis B and/or C virus; G2-patients with elevated ALT; G3-patients with normal ALT and no hepatotropic virus infection. Demographic, epidemiologic and clinical characteristics were compared between the groups. Patients with HEV infection (previous or current) were also compared to those who tested negative for HEV. HEV infection was detected using serologic (anti-HEV IgG) and molecular (HEV RNA) methods. Anti-HEV IgG was positive in 28 (15%) while HEV RNA was positive in 20 (10%). When both markers were considered, 44 (23%) patients showed evidence of previous or current HEV infection. However, both markers were concomitantly positive in only four cases (2%). In the comparative analysis, patients infected with HBV and/or HCV showed lower frequency of anti-HEV IgG (P = 0.009). There was no difference regarding demographic, epidemiologic and laboratory variable between viremic and non-viremic patients. In conclusion, past and current infection with HEV was a frequent finding among renal transplant recipients. Actively infected patients (HEV RNA positive) did not present distinct demographic and epidemiological characteristics or laboratory alterations suggestive of underlying liver damage. Therefore, infection with HEV can only be detected in immunosuppressed patients by systematic investigation of HEV RNA.
authors.affiliation: Department of Gastroenterology, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Tiago
authors.initials: T
authors.lastname: Hering
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Passos
authors.forename: Renata Mello
authors.initials: RM
authors.lastname: Perez
authors.forename: Juliana
authors.initials: J
authors.lastname: Bilar
authors.forename: Daniel
authors.initials: D
authors.lastname: Fragano
authors.forename: Celso
authors.initials: C
authors.lastname: Granato
authors.forename: José Osmar
authors.initials: JO
authors.lastname: Medina-Pestana
authors.forename: Maria Lucia Gomes
authors.initials: ML
authors.lastname: Ferraz
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000453:epidemiology*; D016752:Hepatitis E virus / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D007074:Immunoglobulin G / Q000097:blood; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood; D066027:Transplant Recipients
chemical_list: D006508:Hepatitis Antibodies; D007074:Immunoglobulin G; D012367:RNA, Viral
keywords: ALT; HEV RNA; anti-HEV; hepatitis E; kidney transplantation