title: Copper-catalyzed direct amination of quinoline N-oxides via C-H bond activation under mild conditions.
abstract: A highly efficient and concise one-pot strategy for the direct amination of quinoline N-oxides via copper-catalyzed dehydrogenative C-N coupling has been developed. The desired products were obtained in good to excellent yields for 22 examples starting from the parent aliphatic amines. This methodology provides a practical pathway to 2-aminoquinolines and features a simple system, high efficiency, environmental friendliness, low reaction temperature, and ligand, additives, base, and external oxidant free conditions.
authors.affiliation: Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University , Zhengzhou 450052, P. R. China.
authors.forename: Chongwei
authors.initials: C
authors.lastname: Zhu
authors.forename: Meiling
authors.initials: M
authors.lastname: Yi
authors.forename: Donghui
authors.initials: D
authors.lastname: Wei
authors.forename: Xuan
authors.initials: X
authors.lastname: Chen
authors.forename: Yangjie
authors.initials: Y
authors.lastname: Wu
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui
mesh_terms: D000586:Amination; D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D010087:Oxides / Q000737:chemistry*
chemical_list: D000634:Aminoquinolines; D010087:Oxides; D003300:Copper