title: Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery.
abstract: Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia. c.yu@uq.edu.au.
authors.forename: Amirali
authors.initials: A
authors.lastname: Popat
authors.forename: Siddharth
authors.initials: S
authors.lastname: Jambhrunkar
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Honwei
authors.initials: H
authors.lastname: Zhang
authors.forename: Anand
authors.initials: A
authors.lastname: Meka
authors.forename: Chengzhong
authors.initials: C
authors.lastname: Yu
mesh_terms: D000284:Administration, Oral; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D041981:Gastrointestinal Tract / Q000201:enzymology; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry*; D012460:Sulfasalazine / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D011355:Prodrugs; D012460:Sulfasalazine; D012822:Silicon Dioxide