title: A case of metastatic non-neural granular cell tumor in a 13-year-old girl.
abstract: Conventional granular cell tumor represents a mesenchymal neoplasm observed in a variety of locations and is now believed to be of Schwann cell origin. Granular cell change has also been observed in a variety of different tumors, but recently described in the skin has been a distinct entity termed non-neural granular cell tumor, which lacks expression of S100 protein and is of uncertain histogenesis. This tumor typically displays a greater degree of nuclear atypia and mitotic activity than conventional granular cell tumor but appears to behave in a relatively benign fashion, as only two previous instances of lymph node metastasis have been documented. Herein, we report a case of non-neural granular cell tumor arising on the back of a 13-year-old girl, and later axillary lymph node metastasis with extracapsular extension was observed.
authors.affiliation: Department of Cellular Pathology, The Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Newton
authors.forename: Michael
authors.initials: M
authors.lastname: Schenker
authors.forename: Viney
authors.initials: V
authors.lastname: Wadehra
authors.forename: Akhtar
authors.initials: A
authors.lastname: Husain
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D016586:Granular Cell Tumor / Q000378:metabolism / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins
keywords: S100; dermatopathology; skin tumors