title: Nuclear survivin expression in stromal cells of phyllodes tumors and fibroadenomas of the breast.
abstract: OBJECTIVE
  Survivin is expressed in the nucleus and/or cytoplasm of various types of malignant tumor cells. Nuclear survivin is indispensable for complete mitosis, while cytoplasmic survivin functions as an apoptosis inhibitor. We examined the difference in the survivin expression among stromal cells of fibroadenoma, and benign and malignant phyllodes tumors.
  
  
  METHODS
  Tumor sections were immunohistochemically stained with an anti-human survivin antibody and the labeling index of survivin was calculated.
  
  
  RESULTS
  In stromal cells of all tumors, survivin was expressed in the nuclei but not in the cytoplasm. The labeling indices of the stromal cells in five malignant phyllodes tumors (20.5±3.0) were significantly greater than those observed in eight fibroadenomas (1.9±0.6) or nine benign phyllodes tumors (3.0±0.9).
  
  
  CONCLUSIONS
  In the present study it was shown that stromal cells in malignant phyllodes tumors express nuclear survivin more extensively than stromal cells in benign phyllodes tumors or fibroadenomas.
authors.affiliation: Department of Laboratory Medicine, Toneyama National Hospital, 1-1, Toneyama 5-Chome, Toyonaka, Osaka, 560-8552 Japan. hihirano@toneyama.go.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirano
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Matsushita
authors.forename: Akira
authors.initials: A
authors.lastname: Okimura
authors.forename: Toshimi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Kizaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Ito
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D018226:Fibroadenoma / Q000378:metabolism* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D003557:Phyllodes Tumor / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D017154:Stromal Cells / Q000378:metabolism* / Q000473:pathology; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin
keywords: Survivin; breast; fibroadenoma; nucleus; phyllodes tumors