title: Palladium(II)-catalyzed ortho-C-H arylation/alkylation of N-benzoyl α-amino ester derivatives.
abstract: The palladium-catalyzed arylation/alkylation of ortho-C-H bonds in N-benzoyl α-amino ester derivatives is described. In such a system both the NH-amido and the CO2R groups in the α-amino ester moieties play a role in successful C-H activation/C-C bond formation using iodoaryl coupling partners. A wide variety of functional groups and electron-rich/deficient iodoarenes are tolerated. The yields obtained range from 20 to 95%.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan), Fax: (+81) 6-6879-7396.
authors.forename: Luis C
authors.initials: LC
authors.lastname: Misal Castro
authors.forename: Naoto
authors.initials: N
authors.lastname: Chatani
mesh_terms: D000478:Alkylation; D001224:Aspartic Acid / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D004952:Esters; D005998:Glycine / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D004952:Esters; D001224:Aspartic Acid; D010165:Palladium; D002244:Carbon; D006859:Hydrogen; D005998:Glycine
keywords: CH activation; alkylation; arylation; palladium catalysis; α-amino esters