title: A scalable and regioselective synthesis of 2-difluoromethyl pyridines from commodity chemicals.
abstract: A scalable de novo synthesis of difluoromethyl pyridines from inexpensive materials is reported. The pyridyl subunit is built around the difluoromethyl group rather than a late stage introduction of this moiety. This user-friendly approach allows access to a diverse range of substitution patterns on all positions on the ring system and on the difluoromethyl group.
authors.affiliation: Department of Chemical Development US, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Jean-Nicolas
authors.initials: JN
authors.lastname: Desrosiers
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Kelly
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Fandrick
authors.forename: Larry
authors.initials: L
authors.lastname: Nummy
authors.forename: Scot J
authors.initials: SJ
authors.lastname: Campbell
authors.forename: Xudong
authors.initials: X
authors.lastname: Wei
authors.forename: Max
authors.initials: M
authors.lastname: Sarvestani
authors.forename: Heewon
authors.initials: H
authors.lastname: Lee
authors.forename: Alexander
authors.initials: A
authors.lastname: Sienkiewicz
authors.forename: Sanjit
authors.initials: S
authors.lastname: Sanyal
authors.forename: Xingzhong
authors.initials: X
authors.lastname: Zeng
authors.forename: Nelu
authors.initials: N
authors.lastname: Grinberg
authors.forename: Shengli
authors.initials: S
authors.lastname: Ma
authors.forename: Jinhua J
authors.initials: JJ
authors.lastname: Song
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
mesh_terms: D020650:Combinatorial Chemistry Techniques; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry / Q000191:economics; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000191:economics; D013237:Stereoisomerism
chemical_list: D006845:Hydrocarbons, Fluorinated; D011725:Pyridines