title: Primary localized cutaneous nodular amyloidosis of the feet: a case report and review of the literature.
abstract: Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare disorder that manifests as the cutaneous formation of nodules composed of light-chain amyloid. Although the type of amyloid deposit is similar to primary systemic amyloidosis, there seems to be little, if any, crossover between the 2 diseases. Because reports of PLCNA are sparse, there is no established protocol for treating this disease. This case report presents a 42-year-old man with a visually striking presentation of PLCNA on both feet with some of the lesions possibly being secondary to trauma, a rare phenomenon. The lesions had been present for more than 4 years, and there were no signs or symptoms of systemic amyloidosis. The lesions responded well to a combination of complete curettage followed by CO2; laser ablation. Primary localized cutaneous nodular amyloidosis is rare and difficult to treat, with high rates of recurrence and a concern for progression to systemic amyloidosis. The diagnosis, workup, treatment, and monitoring of PLCNA also are discussed.
authors.affiliation: 59 MDSP/SG07D, 2200 Bergquist Dr, Ste 1, JBSA-Lackland, TX 78236, USA. simonaritchie@hotmail.com.
authors.forename: Simon A
authors.initials: SA
authors.lastname: Ritchie
authors.forename: Thomas
authors.initials: T
authors.lastname: Beachkofsky
authors.forename: Stephan
authors.initials: S
authors.lastname: Schreml
authors.forename: Anthony
authors.initials: A
authors.lastname: Gaspari
authors.forename: Chad M
authors.initials: CM
authors.lastname: Hivnor
mesh_terms: D000328:Adult; D028226:Amyloidosis, Familial / Q000473:pathology* / Q000628:therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005533:Foot Dermatoses / Q000473:pathology* / Q000628:therapy; D006801:Humans; D053685:Laser Therapy / Q000379:methods; D008297:Male; D012873:Skin Diseases, Genetic / Q000473:pathology* / Q000628:therapy; D014221:Triamcinolone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D014221:Triamcinolone