title: Lactating and nonlactating rats differ to renal toxicity induced by mercuric chloride: the preventive effect of zinc chloride.
abstract: This study evaluated the effects of HgCl2 on renal parameters in nonlactating and lactating rats and their pups, as well as the preventive role of ZnCl2 . Rats received 27 mg kg(-1) ZnCl2 for five consecutive days and 5 mg kg(-1) HgCl2 for five subsequent days (s.c.). A decrease in δ-aminolevulinic acid dehydratase (δ-ALA-D) activity in the blood and an increase in urine protein content in renal weight as well as in blood and urine Hg levels were observed in lactating and nonlactating rats from Sal-Hg and Zn-Hg groups. ZnCl2 prevented partially the δ-ALA-D inhibition and the proteinuria in nonlactating rats. Renal Hg levels were increased in all HgCl2 groups, and the ZnCl2 exposure potentiated this effect in lactating rats. Nonlactating rats exposed to HgCl2 exhibited an increase in plasma urea and creatinine levels, δ-ALA-D activity inhibition and histopathological alterations (necrosis, atrophic tubules and collagen deposition) in the kidneys. ZnCl2 exposure prevented the biochemical alterations. Hg-exposed pups showed lower body and renal weight and an increase in the renal Hg levels. In conclusion, mercury-induced nephrotoxicity differs considerably between lactating and nonlactating rats. Moreover, prior exposure with ZnCl2 may provide protection to individuals who get exposed to mercury occupationally or accidentally.
authors.affiliation: Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Alexandre M
authors.initials: AM
authors.lastname: Favero
authors.forename: Cláudia S
authors.initials: CS
authors.lastname: Oliveira
authors.forename: Carina
authors.initials: C
authors.lastname: Franciscato
authors.forename: Vitor A
authors.initials: VA
authors.lastname: Oliveira
authors.forename: Juliana S F
authors.initials: JS
authors.lastname: Pereira
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Bertoncheli
authors.forename: Sônia C A
authors.initials: SC
authors.lastname: da Luz
authors.forename: Valderi L
authors.initials: VL
authors.lastname: Dressler
authors.forename: Erico M M
authors.initials: EM
authors.lastname: Flores
authors.forename: Maria E
authors.initials: ME
authors.lastname: Pereira
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007774:Lactation; D008627:Mercuric Chloride / Q000633:toxicity*; D008628:Mercury / Q000097:blood; D000623:Porphobilinogen Synthase / Q000378:metabolism; D011506:Proteins / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000097:blood; D017967:Zinc Compounds / Q000494:pharmacology*
chemical_list: D002712:Chlorides; D011506:Proteins; D017967:Zinc Compounds; D008627:Mercuric Chloride; C016837:zinc chloride; D003404:Creatinine; D000623:Porphobilinogen Synthase; D008628:Mercury; D015032:Zinc
keywords: kidney; lactation; mercuric chloride; nephrotoxicity; zinc chloride