title: Microfluidic-assisted self-assembly of complex dendritic polyethylene drug delivery nanocapsules.
abstract: Microfluidic platform for the synthesis of complex nanocapsules is presented via a controlled self-assembly. The monodisperse nanocapsules in the range of 50-200 nm consist of a dendritic polyethylene core and a Pluronic copolymer shell. The resultant nanocarriers encapsulate large amount of hydrophobic anticancer drug like paclitaxel while providing a low complement activation as well as sustained release profile with high tunability.
authors.affiliation: Laboratoire de Microsystemes (LMIS4), Institute of Microengineering, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland; School of Materials Science and Engineering and G. W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0295, USA; Center of Excellence in Biomaterials, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Hasani-Sadrabadi
authors.forename: Vahid
authors.initials: V
authors.lastname: Karimkhani
authors.forename: Fatemeh Sadat
authors.initials: FS
authors.lastname: Majedi
authors.forename: Jules John
authors.initials: JJ
authors.lastname: Van Dersarl
authors.forename: Erfan
authors.initials: E
authors.lastname: Dashtimoghadam
authors.forename: Faramarz
authors.initials: F
authors.lastname: Afshar-Taromi
authors.forename: Hamid
authors.initials: H
authors.lastname: Mirzadeh
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bertsch
authors.forename: Karl I
authors.initials: KI
authors.lastname: Jacob
authors.forename: Philippe
authors.initials: P
authors.lastname: Renaud
authors.forename: Florian J
authors.initials: FJ
authors.lastname: Stadler
authors.forename: Il
authors.initials: I
authors.lastname: Kim
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D050091:Dendrimers / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D061986:MCF-7 Cells; D008264:Macrophages / Q000166:cytology / Q000276:immunology; D051379:Mice; D046210:Microfluidic Analytical Techniques; D053769:Nanocapsules / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry / Q000633:toxicity; D010316:Particle Size; D010587:Phagocytosis; D020959:Polyethylene / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D050091:Dendrimers; D053769:Nanocapsules; D020959:Polyethylene; D017239:Paclitaxel
keywords: cancer therapeutics; controlled drug delivery; hyperbranched polyethylene nanocapsule; microfluidic-assisted self-assembly; paclitaxel