title: Clinicopathologic analysis of pituitary adenoma: a single institute experience.
abstract: Pituitary adenoma (PA) is a common benign neuroendocrine tumor; however, the incidence and proportion of hormone-producing PAs in Korean patients remain unknown. Authors analyzed 506 surgically resected and pathologically proven pituitary lesions of the Seoul National University Hospital from 2006 to 2011. The lesions were categorized as: PAs (n = 422, 83.4%), Rathke's cleft cysts (RCCs) (n = 54, 10.6%), inflammatory lesions (n = 8, 1.6%), meningiomas (n = 4), craniopharyngiomas (n = 4), granular cell tumors (n = 1), metastatic renal cell carcinomas (n = 2), germinomas (n = 1), ependymomas (n = 1), and unsatisfactory specimens (n = 9, 1.8%). PAs were slightly more prevalent in women (M: F = 1:1.17) with a mean age of 48.8 yr (9-80 yr). Immunohistochemical analysis revealed that prolactin-producing PAs (16.6%) and growth hormone-producing adenomas (9.2%) were the most common functional PAs. Plurihormonal PAs and nonfunctioning (null cell) adenomas were found in 14.9% and 42.4% of patients with PAs, respectively. The recurrence rate of PAs was 11.1%, but nearly 0% for the remaining benign lesions such as RCCs. 25.4% of patients with PAs were treated by gamma-knife after surgery due to residual tumors or regrowth of residual tumor. In conclusion, the pituitary lesions and the proportions of hormone-producing PAs in Korean patients are similar to those of previous reports except nonfunctioning (null cell) PAs, which are unusually frequent.
authors.affiliation: Department of Pathology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hwa Jin
authors.identifier: 0000-0002-7613-1942
authors.initials: HJ
authors.lastname: Cho
authors.affiliation: Department of Pathology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hanna
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Pathology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Yoon Jin
authors.initials: YJ
authors.lastname: Kwak
authors.affiliation: Department of Pathology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jeong Wook
authors.identifier: 0000-0003-0242-1805
authors.initials: JW
authors.lastname: Seo
authors.affiliation: Department of Neurosurgery, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Paek
authors.affiliation: Department of Neuroradiology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Sohn
authors.affiliation: Department of Industrial Engineering, Ajou University, Suwon, Korea.
authors.forename: Jung Min
authors.identifier: 0000-0002-7141-0440
authors.initials: JM
authors.lastname: Yun
authors.affiliation: Department of Industrial Engineering, Ajou University, Suwon, Korea.
authors.forename: Da Seu Ran
authors.initials: DS
authors.lastname: Kim
authors.affiliation: Department of Industrial Engineering, Ajou University, Suwon, Korea.
authors.forename: Peter
authors.initials: P
authors.lastname: Kang
authors.affiliation: Department of Industrial Engineering, Ajou University, Suwon, Korea.
authors.forename: Peom
authors.initials: P
authors.lastname: Park
authors.affiliation: Department of Pathology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea. ; Neuroscience Institute, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Sung-Hye
authors.identifier: 0000-0002-8681-1597
authors.initials: SH
authors.lastname: Park
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D020863:Central Nervous System Cysts / Q000473:pathology; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000473:pathology*; D011388:Prolactin / Q000378:metabolism; D012008:Recurrence; D012737:Sex Factors; D055815:Young Adult
chemical_list: D011388:Prolactin; D013006:Growth Hormone
keywords: Clinicopathological Study; Pituitary Adenoma; Pituitary Gland; Pituitary Hormone; Pituitary Neoplasms