title: Mean platelet volume and vitamin D level.
abstract: BACKGROUND
  Vitamin D deficiency and a high mean platelet volume (MPV) are related to cardiovascular disease. We investigated whether vitamin D deficiency is associated with high MPV.
  
  
  METHODS
  This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was measured by chemiluminescent microparticle immunoassay on the Architect-I2000 system (Abbott Diagnostics, USA), and MPV was measured on the Cell-Dyn Ruby analyzer (Abbott Diagnostics). Patients were divided into Groups 1 (138 [men/women, 46/92]), 2 (148 [men/women, 54/94]), and 3 (148 [men/women, 50/98]) according to vitamin D levels of <10 ng/mL, 10-20 ng/mL, and >20 ng/mL, respectively.
  
  
  RESULTS
  The vitamin D level in Group 1 (7.7±1.9 ng/mL) was lower than that in Group 2 (15.1±1.6 ng/mL, P<0.001) and Group 3 (25.6±6.3 ng/mL, P<0.001). The MPV in Group 3 (7.5±1.0 fL) was lower than that in Group 1 (8.1±1.1 fL, P<0.001) and Group 2 (7.9±1.0 fL, P=0.009). Linear regression analysis showed that low levels of vitamin D (β=-0.109, P=0.019) was independently associated with increased MPV.
  
  
  CONCLUSIONS
  There was a strong association between a low vitamin D level and a high MPV; therefore, vitamin D deficiency may be associated with increased MPV.
authors.affiliation: Department of Biochemistry, University of Recep Tayyip Erdogan, Rize, Turkey.
authors.forename: Medine
authors.initials: M
authors.lastname: Cumhur Cure
authors.affiliation: Department of Internal Medicine, University of Recep Tayyip Erdogan, Rize, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Cure
authors.affiliation: Department of Internal Medicine, University of Recep Tayyip Erdogan, Rize, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Yuce
authors.affiliation: Department of Biochemistry, University of Recep Tayyip Erdogan, Rize, Turkey.
authors.forename: Tarkan
authors.initials: T
authors.lastname: Yazici
authors.affiliation: Department of Biochemistry, Izmir Public Health Laboratory, Izmir, Turkey.
authors.forename: Inanc
authors.initials: I
authors.lastname: Karakoyun
authors.affiliation: Department of Biochemistry, University of Recep Tayyip Erdogan, Rize, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Efe
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis; D001792:Blood Platelets / Q000166:cytology*; D048429:Cell Size; D005260:Female; D006801:Humans; D007118:Immunoassay; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000032:analysis*; D014808:Vitamin D Deficiency / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D014807:Vitamin D
keywords: Cardiovascular diseases; Deficiency; Mean platelet volume; Vitamin D