title: Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex.
abstract: One novel p-terphenyl compound, polyozellic acid (1), and its acetone adduct (3), along with a known p-terphenyl compound, thelephoric acid (2), were isolated from the mushroom Polyozellus multiplex. Their molecular structures were determined by spectroscopic analysis, X-ray crystallographic analysis, and chemical modification. In some assays related to angiogenesis, compounds 1 and 2 in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical vein endothelial cells. The quinone moiety within these molecules possibly contributes to their antiangiogenesis activity.
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University , Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Nagasawa
authors.forename: Akira
authors.initials: A
authors.lastname: Kaneko
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kazuto
authors.initials: K
authors.lastname: Nishio
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Motto
authors.initials: M
authors.lastname: Shiro
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Koyama
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D007564:Japan; D008968:Molecular Conformation; D015394:Molecular Structure; D013730:Terphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D020533:Angiogenesis Inhibitors; D013730:Terphenyl Compounds; C000589782:polyozellic acid; C000589783:thelephoric acid