title: Phase distribution of chronic myeloid leukemia in Bangladesh.
abstract: BACKGROUND
  Here, we report the phase distribution of chronic myeloid leukemia (CML), defined based on the World Health Organization criteria, among 63 patients in Bangladesh. All patients were diagnosed based on complete blood count, bone marrow examination including bone marrow aspiration and reverse-transcriptase polymerase chain reaction (RT-PCR). Out of 63 patients, 42 were male and 21 were female. The mean age of the subjects was 37.4 years, with an age range of 17-60 years. The majority of patients (86%) were classified in the chronic phase (CP), 7 (11%) in the accelerated phase (AP) and two (3%) in blast crisis (BC). The most frequent patient age ranges were 21-30 years for CP, 41-50 years for AP and 41-50 years for BC.
  
  
  RESULTS
  The Philadelphia chromosome was detected in 48 patients by RT-PCR. The mean total leukocyte counts, platelet counts, hemoglobin levels and marrow blast frequencies were 101 × 10(9)/L, 409 × 10(9)/L, 12.2 g/dl and 2.8% for CP; 121 × 10(9)/L, 418 × 10(9)/L, 8.7 g/dl and 15% for AP and 311 × 10(9)/L, 396 × 10(9)/L, 9.2 g/dl and 26% for BC, respectively.
  
  
  CONCLUSIONS
  This study concluded that most CML patients in Bangladesh are from a younger age group (31-40 years). In addition, males were more commonly affected, although females were afflicted with this disease at a younger age.
authors.forename: Md Abdul
authors.initials: MA
authors.lastname: Mottalib
authors.forename: Tanvira Afroze
authors.initials: TA
authors.lastname: Sultana
authors.affiliation: Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka, Bangladesh. drmikhalil@yahoo.com.
authors.forename: Md Ibrahim
authors.initials: MI
authors.lastname: Khalil
authors.forename: Siew Hua
authors.initials: SH
authors.lastname: Gan
authors.forename: Md Sirazul
authors.initials: MS
authors.lastname: Islam
authors.forename: Subhagata
authors.initials: S
authors.lastname: Choudhury
authors.forename: M Anwar
authors.initials: MA
authors.lastname: Hossain
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001459:Bangladesh; D001752:Blast Crisis / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D001772:Blood Cell Count; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015465:Leukemia, Myeloid, Accelerated Phase / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D015466:Leukemia, Myeloid, Chronic-Phase / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D010677:Philadelphia Chromosome; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012737:Sex Factors; D055815:Young Adult
chemical_list: C581634:BCR-ABL1 fusion protein, human; D016044:Fusion Proteins, bcr-abl