title: Pharmacoeconomic impact evaluation of statin adherence in high-risk unselected post myocardial infarction population: an administrative database-guided analysis.
abstract: BACKGROUND
  The compliance to statins in secondary prevention is very low, increasing health-care costs principally for rehospitalization.
  
  
  OBJECTIVE
  To evaluate the cost of lack of persistence to statin therapy together with identification and cost-estimation of poor compliance.
  
  
  METHODS
  Retrospective observational study starting from administrative database analysis of statin prescription after myocardial infarction.
  
  
  RESULTS
  Among 463 patients enrolled, 25.1% were never treated, 70.8% received statins regularly; 14.9% received only 1-2 prescriptions (spot prescription), and 12% were occasional users. Among the 288 nonoccasional users, we found a compliance rate of 80% only in the 59.7%. The cost analysis shows that 59.787,72 euros (23.4%) have been spent for patients with compliance of less than 80% (ineffective adherence).
  
  
  CONCLUSIONS
  As the lower compliance affects the health-care costs, the identification of occasional users and spot prescriptions of the nonoccasional users, has a potential role in reducing medical expense with limited increase in costs.
authors.affiliation: Cardiology-Policlinico Casilino, Rome, Italy. f.summaria@gmail.com
authors.forename: Francesco
authors.initials: F
authors.lastname: Summaria
authors.affiliation: ASL Roma B, Rome, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ciaralli
authors.affiliation: CCU-"S. Pertini" Hospital, Rome, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Mustilli
authors.affiliation: Cardiology-Policlinico Casilino, Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Sette
authors.affiliation: Cardiology-Policlinico Casilino, Rome, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Lanzillo
authors.affiliation: ASL Roma B, Rome, Italy.
authors.forename: Loredana
authors.initials: L
authors.lastname: Vasselli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016208:Databases, Factual; D005260:Female; D019983:Guideline Adherence / Q000191:economics / Q000706:statistics & numerical data*; D017048:Health Care Costs; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy*; D007558:Italy; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000191:economics / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D055502:Secondary Prevention / Q000191:economics / Q000592:standards; D016903:Drug Monitoring
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors