title: Direct UV-induced functionalization of surface hydroxy groups by thiol-ol chemistry.
abstract: A novel UV-initiated surface modification method for the direct functionalization of surface hydroxy groups with thiol-containing molecules (termed "thiol-ol" modification) is described. This method is based on the oxidative conjugation of thiols to hydroxy groups. We demonstrate that different thiol-containing molecules, such as fluorophores, thiol-terminated poly(ethylene glycol) (PEG-SH), and a cysteine-containing peptide, can be attached onto the surface of porous poly(2-hydroxyethyl methacrylate-co-ethylene dimethacrylate). Direct functionalization of other hydroxy-group-bearing surfaces, fabrication of micropatterns, and double patterning have been also demonstrated using the thiol-ol method.
authors.affiliation: Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), 76344 Karlsruhe (Germany); Department of Organic Chemistry, University of Heidelberg (Germany).
authors.forename: Linxian
authors.initials: L
authors.lastname: Li
authors.forename: Junsheng
authors.initials: J
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Du
authors.forename: Alexander
authors.initials: A
authors.lastname: Welle
authors.forename: Michael
authors.initials: M
authors.lastname: Grunze
authors.forename: Oliver
authors.initials: O
authors.lastname: Trapp
authors.forename: Pavel A
authors.initials: PA
authors.lastname: Levkin
keywords: alcohols; photochemistry; photopatterning; surface chemistry; thiols