title: Eruca sativa and its flavonoid components, quercetin and isorhamnetin, improve skin barrier function by activation of peroxisome proliferator-activated receptor (PPAR)-α and suppression of inflammatory cytokines.
abstract: Atopic dermatitis, which is related to dermatologic disorders and is associated with skin barrier dysfunction, represents an epidemic problem demanding effective therapeutic strategies. In the present study, we showed that the treatment with Eruca sativa extract resulted in a significant increase in the transactivation activity of peroxisome proliferator-activated receptor (PPAR) response element such as PPAR-α and suppression in the expression of inflammatory cytokine and antimicrobial peptides. In addition, E. sativa extract promotes the expression of filaggrin related to skin barrier protection. Quercetin and isorhamnetin, flavonoids' constituents of E. sativa, also promoted PPAR-α activity. These results indicate that E. sativa extract may be an appropriate material for improving skin barrier function as a skin therapeutic agent for atopic dermatitis.
authors.affiliation: Skin & Bio Research, Ellead Co., Ltd., 325, Hwangsaeul-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-824, Republic of Korea.
authors.forename: Bora
authors.initials: B
authors.lastname: Kim
authors.forename: Yoon-E
authors.initials: YE
authors.lastname: Choi
authors.forename: Hyun-Soo
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D019607:Brassicaceae / Q000737:chemistry*; D002460:Cell Line; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism*; D003876:Dermatitis, Atopic / Q000188:drug therapy; D005347:Fibroblasts / Q000187:drug effects; D000091344:Filaggrin Proteins; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism; D015603:Keratinocytes / Q000187:drug effects; D047493:PPAR alpha / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D011498:Protein Precursors / Q000378:metabolism; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D012867:Skin / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016207:Cytokines; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D005419:Flavonoids; D007381:Intermediate Filament Proteins; D047493:PPAR alpha; D010936:Plant Extracts; D011498:Protein Precursors; C047368:3-methylquercetin; C032253:involucrin; D011794:Quercetin
keywords: Eruca sativa extract; anti-inflammation; filaggrin; flavonoid; peroxisome proliferators-activated receptors