title: [Factors associated with neonatal death in high-risk infants: a multicenter study in High-Risk Neonatal Units in Northeast Brazil].
abstract: This study aimed to identify factors associated with in-hospital mortality in High-Risk Neonatal Units (NICU) belonging to the North-Northeast Perinatal Health Network in Northeast Brazil. The explanatory variables were individual maternal characteristics, prenatal care, childbirth and neonatal care, and infant characteristics. This was a longitudinal, multicenter hospital-based study. The study population consisted of 3,623 live born infants admitted to 34 NICUs. After adjusting for the three hierarchical levels in the model for determination of death in the NICU up to the 27 th day of life, the following showed statistically significant association: type of delivery - cesarean section (OR = 0.72; 95%CI: 0.56-0.95), non-use of prenatal steroids (OR =1.51; 95%CI: 1.01-2.25), preeclampsia (OR = 0.73; 95%CI: 0.56-0.95), oligohydramnios (OR = 1.57; 95%CI: 1, 17-2.10), birth weight < 2500g (OR = 1.40; 95%CI: 1.03-1.90), 5-minute Apgar score < 7 (OR = 2.63; 95%CI: 2.21-3.14), endotracheal intubation (OR = 1.95; 95%CI: 1.31-2.91), and non-use of surfactant (OR = 0.54; 95%CI: 0.43-0.69). Death during NICU care is determined by conditions of the pregnancy, childbirth, and the newborn.
authors.affiliation: Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Brasil, Faculdade de Medicina , Universidade Federal do Ceará , Fortaleza , Brasil .
authors.forename: Cristiana Ferreira da
authors.initials: CF
authors.lastname: Silva
authors.affiliation: Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Brasil, Faculdade de Medicina , Universidade Federal do Ceará , Fortaleza , Brasil .
authors.forename: Álvaro Jorge Madeiro
authors.initials: ÁJ
authors.lastname: Leite
authors.affiliation: Escola de Saúde Pública do Ceará, Fortaleza, Brasil, Escola de Saúde Pública do Ceará , Fortaleza , Brasil .
authors.forename: Nádia Maria Girão Saraiva de
authors.initials: NM
authors.lastname: Almeida
authors.affiliation: Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil, Instituto de Medicina Social , Universidade do Estado do Rio de Janeiro , Rio de Janeiro , Brasil .
authors.forename: Antonio Carlos Monteiro Ponce de
authors.initials: AC
authors.lastname: Leon
authors.affiliation: Harvard School of Public Health, Harvard University, Cambridge, U.S.A, Harvard School of Public Health , Harvard University , Cambridge , U.S.A .
authors.forename: Ibironke
authors.initials: I
authors.lastname: Olofin
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D017052:Hospital Mortality; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007363:Intensive Care Units, Neonatal; D008137:Longitudinal Studies; D008297:Male; D011295:Prenatal Care; D012307:Risk Factors; D012959:Socioeconomic Factors; D055815:Young Adult