title: Thiamin concentration in geriatric hospitalized patients using frusemide.
abstract: OBJECTIVE
  To assess the association between thiamin concentration, frusemide use, and renal function in older adults.
  
  
  METHODS
  Thiamin concentration was measured in 73 consecutive admissions of patients aged over 65 years in a secondary care hospital. The patients were assigned to the study or control group based on frusemide use. A two-sample t test estimated the association between frusemide use and thiamin concentration and regression between thiamin concentration and EGFR.
  
  
  RESULTS
  The mean (SD) thiamin concentration was 181.7 (64.6) nmol/L in those using frusemide and 169.3 (46.8) in non-users, P =0.35. There was a weak linear relationship between thiamin concentration and EGFR, with thiamin concentration being 17.0 nmol/L lower per 30 ml/min greater EGFR, P=0.076. Thiamin concentration was below the reference range in 20/73 (27.4%) of the participants.
  
  
  CONCLUSIONS
  We found no association between frusemide use and thiamin concentration, but showed a significant prevalence of lower thiamin concentration in the study population of older adults.
authors.affiliation: a Wellington Hospital, Capital and Coast District Health Board , Wellington , New Zealand.
authors.forename: Afshin
authors.initials: A
authors.lastname: Nazmi
authors.forename: Mark
authors.initials: M
authors.lastname: Weatherall
authors.forename: Ben
authors.initials: B
authors.lastname: Wilkins
authors.forename: Geoffrey Maxwell
authors.initials: GM
authors.lastname: Robinson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D004232:Diuretics / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005665:Furosemide / Q000009:adverse effects / Q000627:therapeutic use; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D009520:New Zealand / Q000453:epidemiology; D009752:Nutritional Status; D015995:Prevalence; D063728:Secondary Care Centers; D013831:Thiamine / Q000097:blood*; D013832:Thiamine Deficiency / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology*
chemical_list: D004232:Diuretics; D005665:Furosemide; D013831:Thiamine