title: Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor.
abstract: Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.
authors.affiliation: Department of Biomedical Engineering, Fitzpatrick Institute for Photonics, Duke University, Durham, NC 27708, USA. tuan.vodinh@duke.edu.
authors.forename: Hsiangkuo
authors.initials: H
authors.lastname: Yuan
authors.forename: Christy M
authors.initials: CM
authors.lastname: Wilson
authors.forename: Jun
authors.initials: J
authors.lastname: Xia
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Doyle
authors.forename: Shuqin
authors.initials: S
authors.lastname: Li
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Fales
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Ema
authors.initials: E
authors.lastname: Ozaki
authors.forename: Kelly
authors.initials: K
authors.lastname: Mulfaul
authors.forename: Gabi
authors.initials: G
authors.lastname: Hanna
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Palmer
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
authors.forename: Gerald A
authors.initials: GA
authors.lastname: Grant
authors.forename: Tuan
authors.initials: T
authors.lastname: Vo-Dinh
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D005910:Glioma / Q000378:metabolism / Q000473:pathology; D006046:Gold / Q000493:pharmacokinetics / Q000494:pharmacology; D064593:Heterografts; D006801:Humans; D007834:Lasers; D053768:Metal Nanoparticles; D051379:Mice; D009368:Neoplasm Transplantation
chemical_list: D003287:Contrast Media; D006046:Gold