title: Effect of low-fat diet on breast cancer survival: a meta-analysis.
abstract: BACKGROUND
  Even though many studies have examined the possible effect of low-fat diet on breast cancer survival, the relationship remains unclear.
  
  
  OBJECTIVE
  To summarize the current evidence about the effect of post-diagnostic low-fat diet on recurrence and all-cause mortality of breast cancer.
  
  
  METHODS
  We conducted a search of Pubmed, Embase, Web of Science, and Cochrane Library and as a result two randomized controlled trials (RCT) and one large multi-center prospective cohort study with 9,966 breast cancer patients were included in this report.
  
  
  RESULTS
  Post-diagnostic low-fat diet reduced risk of recurrence of breast cancer by 23% (HR=0.77, 95%CI 0.63 to 0.94, P=0.009) and all cause mortality of breast cancer by 17% (HR=0.83, 95%CI 0.69 to 1.00, P=0.05).
  
  
  CONCLUSIONS
  This meta-analysis suggested the post-diagnostic low-fat diet can improve breast cancer survival by reducing risk of recurrence. However, more trials of the relationship between low-fat diet and all- cause mortality of breast cancer are still needed.
authors.affiliation: Library of the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China E-mail : peggyxsz@gmail.com.
authors.forename: Mei-Yuan
authors.initials: MY
authors.lastname: Xing
authors.forename: Su-Zhen
authors.initials: SZ
authors.lastname: Xu
authors.forename: Peng
authors.initials: P
authors.lastname: Shen
mesh_terms: D001943:Breast Neoplasms / Q000178:diet therapy* / Q000401:mortality*; D018752:Diet, Fat-Restricted; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000178:diet therapy*; D016896:Treatment Outcome