title: Cephalic aura after frontal lobe resection.
abstract: A cephalic aura is a common sensory aura typically seen in frontal lobe epilepsy. The generation mechanism of cephalic aura is not fully understood. It is hypothesized that to generate a cephalic aura extensive cortical areas need to be excited. We report a patient who started to have cephalic aura after right frontal lobe resection. Magnetoencephalography (MEG) showed interictal spike and ictal change during cephalic aura, both of which were distributed in the right frontal region, and the latter involved much more widespread areas than the former on MEG sensors. The peculiar seizure onset pattern may indicate that surgical modification of the epileptic network was related to the appearance of cephalic aura. We hypothesize that generation of cephalic aura may be associated with more extensive cortical involvement of epileptic activity than that of interictal activity, in at least a subset of cases.
authors.affiliation: Epilepsy Center, Department of Neurology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA; Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan. Electronic address: kakisuke@mui.biglobe.ne.jp.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kakisaka
authors.affiliation: Epilepsy Center, Department of Neurology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Lara
authors.initials: L
authors.lastname: Jehi
authors.affiliation: The Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.
authors.forename: Rafeed
authors.initials: R
authors.lastname: Alkawadri
authors.affiliation: Epilepsy Center, Department of Neurology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Zhong I
authors.initials: ZI
authors.lastname: Wang
authors.affiliation: Epilepsy Center, Department of Neurology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Rei
authors.initials: R
authors.lastname: Enatsu
authors.affiliation: Epilepsy Center, Department of Neurology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Mosher
authors.affiliation: Epilepsy Center, Department of Neurology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Dubarry
authors.affiliation: Epilepsy Center, Department of Neurology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Andreas V
authors.initials: AV
authors.lastname: Alexopoulos
authors.affiliation: Epilepsy Center, Department of Neurology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Richard C
authors.initials: RC
authors.lastname: Burgess
mesh_terms: D001921:Brain / Q000473:pathology / Q000503:physiopathology; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D005625:Frontal Lobe / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D012640:Seizures / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult
keywords: Cephalic aura; Electroencephalography; Fast activity; Magnetoencephalography