title: [Protective effect of sodium bicarbonate on radiological contrast medium-induced nephropathy in rats].
abstract: Radiological iodinated contrasts (IC) agents cause acute kidney injury (AKI). To evaluate the renoprotective effect of sodium bicarbonate (Bic) on renal function (creatinine clearance [Clcr], Jaffé, and Clcr mLmin -1 x100 g-1) and the oxidative profile (peroxide excretion, urinary peroxides, urinary malondialdehyde, FOX-2 expression, and thiobarbituric acid reactive substance [TBARS; nmol/mg Cr]) in rats treated with an IC agent. Adult male Wistar rats weighing 250-300 g were treated once daily for 5 days with one of the following treatments: saline (0.9%, 3 mL.kg-1xday-1 intraperitoneally [i.p.]), IC agent (sodium and meglumine ioxitalamate, 3 mL/kg, i.p.), Bic + Saline (3-mL/kg Bic, i.p., 1 h before and after saline treatment), and Bic + IC (3-ml/kg Bic, i.p., 1 h before and after the IC treatment). The IC agent induced AKI, and the antioxidant renoprotective effect of Bic was confirmed (Clcr/TBARS/urinary peroxide: saline group, 0.59+/- 0.03/0.11 +/-0.02/1.29+/- 0.24; Bic+Saline group, 0.58 +/-0.03/0.13+/- 0.02/1.32+/- 0.64; IC group, 0.22 +/- 0.02/0.19 +/- 0.02/4.77 +/- 0.24; Bic +Clgroup, 0.51+/- 0.04/0.13+/- 0.3/1.80+/- 0.04; p<0.05). The protective effect of Bic in the IC-induced AKI was confirmed; hence, Bic administration may be considered as a therapeutic option for patients undergoing IC-enhanced radiography.
authors.affiliation: Departamento de Enfermagem Médico-Cirúrgica da Escola de Enfermagem da Universidade de São Paulo. São Paulo, SP, Brasil. nephron@usp.br
authors.forename: Maria deFátima Fernandes
authors.initials: Md
authors.lastname: Vattimo
authors.affiliation: Graduanda da Escola de Enfermagem da Universidade de São Paulo. Bolsista FAPESP. São Paulo, SP, Brasil.
authors.forename: Juliana Guareschi
authors.initials: JG
authors.lastname: dos Santos
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000517:prevention & control*; D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D008297:Male; D011859:Radiography / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D017693:Sodium Bicarbonate / Q000627:therapeutic use*
chemical_list: D003287:Contrast Media; D017693:Sodium Bicarbonate