title: Leukocyte migration in the interstitial space of non-lymphoid organs.
abstract: Leukocyte migration through interstitial tissues is essential for mounting a successful immune response. Interstitial motility is governed by a vast array of cell-intrinsic and cell-extrinsic factors that together ensure the proper positioning of immune cells in the context of specific microenvironments. Recent advances in imaging modalities, in particular intravital confocal and multi-photon microscopy, have helped to expand our understanding of the cellular and molecular mechanisms that underlie leukocyte navigation in the extravascular space. In this Review, we discuss the key factors that regulate leukocyte motility within three-dimensional environments, with a focus on neutrophils and T cells in non-lymphoid organs.
authors.affiliation: 1] Centenary Institute for Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia. [2] Discipline of Dermatology, University of Sydney, New South Wales 2006, Australia. [3] Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weninger
authors.affiliation: 1] Centenary Institute for Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia. [2] Sydney Medical School, The University of Sydney, New South Wales 2006, Australia.
authors.forename: Maté
authors.initials: M
authors.lastname: Biro
authors.affiliation: Centenary Institute for Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia.
authors.forename: Rohit
authors.initials: R
authors.lastname: Jain
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000276:immunology / Q000502:physiology; D060833:Cellular Microenvironment / Q000276:immunology / Q000502:physiology; D002634:Chemotaxis, Leukocyte / Q000276:immunology / Q000502:physiology; D045604:Extracellular Fluid / Q000166:cytology; D006801:Humans; D007962:Leukocytes / Q000276:immunology* / Q000502:physiology*; D008954:Models, Biological; D009504:Neutrophils / Q000276:immunology / Q000502:physiology; D009928:Organ Specificity; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology; D059016:Tumor Microenvironment / Q000276:immunology / Q000502:physiology