title: [Association between colorectal cancer and estrogens].
abstract: Increasing evidences suggest an association between estrogens and colorectal cancer (CRC), especially in postmenopausal women. Inhibitory role has been suggested by CRC risk reduction among women treated with exogeneous hormones or by decrease of estrogen receptor (ER)-beta expression in CRC compared with normal epithelium. Controversial results have been reported in epidemiological studies on endogeneous hormones or CRC cell line assays. Progressive role has been suggested by studies directly examining estrogenic conditions in CRC surgical materials. To further understand the role of estrogens in the pathobiology of colorectal cancer, where wide variety exists, a large, systematic, and comprehensive study considering sex, age, locus, stage, grade, clinical outcome, microsatellite instability, ER-beta status, and estrogen related gene polymorphism is needed.
authors.affiliation: Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology.
authors.forename: Naoko
authors.initials: N
authors.lastname: Honma
authors.affiliation: Department of Pathology, Tokyo Metropolitan Geriatric Hospital.
authors.forename: Tomio
authors.initials: T
authors.lastname: Arai
authors.affiliation: Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Muramatsu
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000209:etiology*; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D011960:Receptors, Estrogen / Q000502:physiology
chemical_list: D004967:Estrogens; D011960:Receptors, Estrogen