title: Sex hormones in the modulation of irritable bowel syndrome.
abstract: Compelling evidence indicates sex and gender differences in epidemiology, symptomatology, pathophysiology, and treatment outcome in irritable bowel syndrome (IBS). Based on the female predominance as well as the correlation between IBS symptoms and hormonal status, several models have been proposed to examine the role of sex hormones in gastrointestinal (GI) function including differences in GI symptoms expression in distinct phases of the menstrual cycle, in pre- and post-menopausal women, during pregnancy, hormonal treatment or after oophorectomy. Sex hormones may influence peripheral and central regulatory mechanisms of the brain-gut axis involved in the pathophysiology of IBS contributing to the alterations in visceral sensitivity, motility, intestinal barrier function, and immune activation of intestinal mucosa. Sex differences in stress response of the hypothalamic-pituitary-adrenal axis and autonomic nervous system, neuroimmune interactions triggered by stress, as well as estrogen interactions with serotonin and corticotropin-releasing factor signaling systems are being increasingly recognized. A concept of "microgenderome" related to the potential role of sex hormone modulation of the gut microbiota is also emerging. Significant differences between IBS female and male patients regarding symptomatology and comorbidity with other chronic pain syndromes and psychiatric disorders, together with differences in efficacy of serotonergic medications in IBS patients confirm the necessity for more sex-tailored therapeutic approach in this disorder.
authors.affiliation: Agata Mulak, Department of Gastroenterology and Hepatology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Mulak
authors.affiliation: Agata Mulak, Department of Gastroenterology and Hepatology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
authors.forename: Yvette
authors.initials: Y
authors.lastname: Taché
authors.affiliation: Agata Mulak, Department of Gastroenterology and Hepatology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
authors.forename: Muriel
authors.initials: M
authors.lastname: Larauche
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000378:metabolism / Q000503:physiopathology; D015897:Comorbidity; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000294:innervation / Q000382:microbiology / Q000503:physiopathology; D043183:Irritable Bowel Syndrome / Q000453:epidemiology / Q000378:metabolism* / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008597:Menstrual Cycle / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000378:metabolism / Q000503:physiopathology; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors; D015398:Signal Transduction
chemical_list: D012739:Gonadal Steroid Hormones
keywords: Brain-gut axis; Irritable bowel syndrome; Microbiota; Pain modulation; Sex hormones