title: Novel insights into the role of microRNA in lung cancer resistance to treatment and targeted therapy.
abstract: Lung cancer is one of the most common malignant tumors and is the leading cause of cancer mortality worldwide. However, drug resistance induced by chemotherapeutants to lung cancer cells is the primary issue during the chemotherapy of lung cancer. Many mechanisms such as the changes of drug metabolism related genes and signal pathways are involved in chemoresistance. MicroRNAs (miRNAs) are a class of endogenetic, non-coding, short-chain and small RNAs that regulate cell growth, apoptosis and signal transduction. There are growing numbers of evidence suggesting that miRNA polymorphisms associate with drug metabolism and resistance. In addition, differentially expressed miRNAs play critical roles in the prediction of the sensitivity to chemotherapeutic agents in lung cancer. The recent progress demonstrates that regulation of specific miRNA expression will break novel paths for overcoming lung cancer resistance and the personalized therapy. Together, in this review we have discussed the current understanding of the role of miRNA on drug resistance, and the potential implications of miRNA in lung cancer targeted therapy.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Gong
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Jingqiu
authors.initials: J
authors.lastname: Li
authors.forename: Lihua
authors.initials: L
authors.lastname: Yang
authors.forename: Yanping
authors.initials: Y
authors.lastname: Le
authors.forename: Shaomin
authors.initials: S
authors.lastname: Wang
authors.affiliation: Institute of Biochemistry and Molecular Biology, Ningbo University School of Medicine, 818 Fenghua Road, Ningbo, ZJ 315211, China. zhaohui@ncri.org.cn.
authors.forename: Hui-Kuan
authors.initials: HK
authors.lastname: Lin
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D035683:MicroRNAs / Q000502:physiology*; D009362:Neoplasm Metastasis; D011110:Polymorphism, Genetic; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs