title: [Effect of monoamine neurotransmitter on megakaryocytopoiesis and platelet functions].
abstract: The nervous system directly regulates immunity through neurotransmitter receptors expressed on immune cells to participate in host defense and body reparation. Expression of neurotransmitter receptors on blood cells provides important evidence for a direct functional link between the nervous and hematopoietic systems. Our previous studies showed that 5-hydroxytryptamine, as a monoamine neurotransmitter, plays an important role in regulating megakaryocytopoiesis. This review summarizes recent findings of the effect of monoamine neurotransmitter on megakaryocytopoiesis and platelet function, focusing on the receptor expression on hematopoietic stem cells, megakaryocytes/platelets and their functions in order to explore the intrinsic relation of nervous system and hematopoietic system. Based on the existing research results, we find that the monoamine neurotransmitter participates in regulation of megakaryocytopoiesis, and affects on aggregation and functions activation of platelets. Moreover, it has a close link with the specific regulatory factor of megakaryocytopoiesis-TPO. Thus those results also support the "brain-bone marrow-blood-axis" viewpoint of some researchers. At present, the study of the nervous system regulating hematopoiesis is still in its infancy, the exact mechanism remains to be further studied.
authors.affiliation: Department of Hematology, Chengdu Women and Children Central Hospital Affiliated to Chongqing Medical University, Chengdu 610091, Sichuan Province, China.
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Shu
authors.affiliation: Department of Hematology, Chengdu Women and Children Central Hospital Affiliated to Chongqing Medical University, Chengdu 610091, Sichuan Province, China.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Li
authors.affiliation: Department of Hematology, Chongqing Medical University Children's Hospital, Chongqing 400014, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Hematology, Nanfang Hospital, Southern Medical Uniersity, Guangzhou 510515, Guangdong Province, China.
authors.forename: Jie-Yu
authors.initials: JY
authors.lastname: Ye
authors.affiliation: Department of Hematology, Nanfang Hospital, Southern Medical Uniersity, Guangzhou 510515, Guangdong Province, China. E-mail:yangm1091@yahoo.com.hk.
authors.forename: Mo
authors.initials: M
authors.lastname: Yang
mesh_terms: D015306:Biogenic Monoamines / Q000502:physiology*; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D008533:Megakaryocytes / Q000166:cytology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D010979:Platelet Function Tests
chemical_list: D015306:Biogenic Monoamines; D018377:Neurotransmitter Agents