title: MKL1-184C>T gene polymorphism is associated with coronary artery disease in the Chinese Han population.
abstract: We investigated genetic susceptibility to coronary artery disease (CAD) by studying the association of MKL1 gene polymorphisms with CAD in the Chinese Han population. We performed a case-control study with 476 unrelated CAD patients and 325 non-CAD controls. All SNPs were genotyped with a TaqMan SNP genotyping assay. The distribution of MKL1-184C>T gene polymorphism in each group was in Hardy-Weinberg equilibrium. The frequency of the MKL1 T allele in the CAD group was significantly higher than in the control group (38.6 vs 30.8%). After logistic regression models adjusted for CAD risk factors, the risk of CAD among CT genotypes was 1.765 times higher than among the CC genotypes [odds ration (OR) = 1.765, 95% confidence interval (CI) = 1.246-2.5], and for TT genotypes it was 1.806 times higher than for the CC genotypes (OR = 1.806, 95%CI = 1.203-2.71). In summary, genotypes with at least one T allele (CT or TT genotypes) had a significantly increased CAD risk than the CC genotypes, with a ratio of 1.78 to 1 (OR = 1.780, 95%CI = 1.311-2.418). There was a close association between -184 T allele and 3VD (OR = 1.614, 95%CI = 1.259-2.07, P < 0.05). We conclude that the -184C>T of MKL1 is an important susceptibility factor for CAD in the Han Chinese in Henan Province. Homozygosity for the T allele is not only associated with an increased risk for CAD, it is also correlated with severity of stenosis in the Chinese Han population.
authors.affiliation: Department of Cardiology, People's Hospital of Henan Province, Zhengzhou, China yuxucn@126.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Xinxiang Medical College, Xinxiang, China.
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Eye Institute, People's Hospital of Henan Province, Zhengzhou, China.
authors.forename: Y-Z
authors.initials: YZ
authors.lastname: Bao
authors.affiliation: Xinxiang Medical College, Xinxiang, China.
authors.forename: X-Y
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, People's Hospital of Henan Province, Zhengzhou, China.
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Zhu
authors.affiliation: Xinxiang Medical College, Xinxiang, China.
authors.forename: X-F
authors.initials: XF
authors.lastname: Zhao
authors.affiliation: Xinxiang Medical College, Xinxiang, China.
authors.forename: Y-N
authors.initials: YN
authors.lastname: Shi
authors.affiliation: Xinxiang Medical College, Xinxiang, China.
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.affiliation: Zhengzhou University, Zhengzhou, China.
authors.forename: S-H
authors.initials: SH
authors.lastname: Chen
authors.affiliation: Zhengzhou University, Zhengzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Zhengzhou University, Zhengzhou, China.
authors.forename: C-H
authors.initials: CH
authors.lastname: Cui
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015534:Trans-Activators
chemical_list: D004268:DNA-Binding Proteins; C431575:MRTFA protein, human; D015514:Oncogene Proteins, Fusion; D015534:Trans-Activators