title: Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia.
abstract: BACKGROUND
  In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response.
  
  
  METHODS
  Baseline WBCs and renal and liver function markers were tabulated for responders/nonresponders.
  
  
  RESULTS
  Nonresponders had higher mean baseline creatinine (P=0.005). Creatinine data showed no significant between-group differences by treatment within responder category.
  
  
  CONCLUSIONS
  No relationship was found between baseline WBCs or hepatic function and response. Higher baseline creatinine in nonresponders may not be clinically relevant.
authors.affiliation: University of Nantes, Nantes, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Delaunay
authors.affiliation: Wroclaw Medical University, Wroclaw, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Mazur
authors.affiliation: Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Minden
authors.affiliation: Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wierzbowska
authors.affiliation: Eisai Corporation, Woodcliff Lake, NJ, USA.
authors.forename: Mark M
authors.initials: MM
authors.lastname: Jones
authors.affiliation: Eisai Corporation, Woodcliff Lake, NJ, USA.
authors.forename: Erhan
authors.initials: E
authors.lastname: Berrak
authors.affiliation: The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Hagop M
authors.initials: HM
authors.lastname: Kantarjian
keywords: ALT, alanine aminotransferase; AML, acute myeloid leukemia; AST, aspartate aminotransferase; Acute myeloid leukemia; Adult; BUN, blood urea nitrogen; CR, complete response; CRi, complete response with incomplete blood count recovery; Decitabine; ECOG PS, Eastern Cooperative Oncology Group Performance Status; FAB, French–American–British classification; Leukemia; PR, partial remission; Prognosis; SC, supportive care; WBC, white blood cell