title: Glaucomatous optic neuropathy management: the role of neuroprotective agents.
abstract: Glaucoma is a major cause of worldwide irreversible blindness. The central role of raised intraocular pressure (IOP) is being questioned as many patients continue to demonstrate a clinically downhill course despite initial control of IOP. The latest concept of recognizing glaucoma as a multifactorial, progressive, neurodegenerative disease of retinal ganglion cells (RGCSs) associated with characteristic axon degeneration in the optic nerve emphasizes that several pressure-independent mechanisms are responsible for the development and progression of glaucomatous optic neuropathy. Neuroprotection as a pharmacological strategy to mitigate retinal ganglion cell death has been a popular current approach. The aim of this review is to evaluate the neuroprotective potential of calcium channel blockers in glaucomatous optic neuropathy.
authors.affiliation: Yerevan State Medical University, Yerevan, Armenia.
authors.forename: Marianne
authors.initials: M
authors.lastname: L Shahsuvaryan
keywords: Calcium channel blockers; Ganglion cell neurodegeneration; Glaucoma; Neuroprotection