title: Effects of rehabilitation management on gastric emptying function in older adults with diabetes.
abstract: The relationship between gastric emptying dysfunction and blood glucose concentration in elderly with type 2 diabetes mellitus was investigated, and the effect of rehabilitation exercise prescription training on gastric emptying in the geriatric diabetic patients was evaluated. A total of 160 older type 2 diabetic adults and 30 cases of non-diabetic patients were studied with regard to the gastric half emptying time (GET1/2) of solid meals radiolabelled with 99mTc. Eighty delayed gastric emptying diabetic patients were randomly divided into 4 four groups: rehabilitation exercise + mosapride group (N = 20), rehabilitation exercise group (N = 20), mosapride group (N = 20), and control group (N = 20). The level of blood glucose was measured every six months in a two-year follow-up. The solid GET1/2 of regulated blood glycemic control patients showed no statistically significant differences from non-diabetic patients (P > 0.05). However, the value for poor blood glycemic control patients exhibited significant statistical differences compared with both non-diabetic (P < 0.01) and regulated blood glycemic control group patients (P < 0.01). It showed that the gastric emptying time improved in the rehabilitation exercise group, mosapride group and rehabilitation exercise group + mosapride group after two years of treatment (P < 0.05). Fasting blood glucose in both rehabilitation exercise group and rehabilitation exercise + mosapride group was significantly decreased. Postprandial blood glucose in the rehabilitation exercise group, mosapride group, rehabilitation exercise group + mosapride group was significantly decreased. High blood glucose level can delay gastric emptying in older type 2 diabetic patients. Gastric emptying and blood glucose control affect each other. It was shown that appropriate rehabilitation exercise combined with prokinetic agent may improve gastric emptying in some geriatric type 2 diabetic patients and help control their blood glucose.
authors.affiliation: Office of the Director and Department of Gastroenterology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Shao
authors.affiliation: Department of Gastroenterology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
authors.forename: J F
authors.initials: JF
authors.lastname: Yao
authors.affiliation: Department of Gastroenterology, Huadong Hospital Affiliated to Fudan University, Shanghai, China jiechencn@yeah.net.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
authors.forename: Z W
authors.initials: ZW
authors.lastname: Yu
authors.affiliation: Department of Gastroenterology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
authors.forename: X F
authors.initials: XF
authors.lastname: Yu
authors.affiliation: Department of Rehabilitation Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
authors.forename: J J
authors.initials: JJ
authors.lastname: Zheng
authors.affiliation: Department of Nuclear Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
authors.forename: X
authors.initials: X
authors.lastname: Tang
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000534:rehabilitation*; D005260:Female; D005746:Gastric Emptying; D006801:Humans; D008297:Male; D019518:Postprandial Period; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D013667:Technetium