title: The Cancer Genome Atlas: clinical applications for breast cancer.
abstract: Advances in next-generation sequencing technologies in recent years have allowed in-depth study of somatic mutations in over 1,000 breast cancer samples.The Cancer Genome Atlas (TCGA) is the largest single genome-characterization effort to date. It is remarkable for the integration of DNA sequencing with genome-wide profiling of the epigenome, microRNAome, transcriptome, and proteome for more than 500 diverse primary untreated breast cancers. This article aims to provide an overview ofTCGA findings, with a particular focus on their potential biological relevance and therapeutic implications.
authors.forename: Cynthia X
authors.initials: CX
authors.lastname: Ma
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Ellis
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D005260:Female; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D009154:Mutation / Q000235:genetics*; D015398:Signal Transduction