title: Study on clinical application of nano-hydroxyapatite bone in bone defect repair.
abstract: OBJECTIVE
  To study the clinical effect of bone defect treated with nano-hydroxyapatite(Nano-HA) artificial bone.
  
  
  METHODS
  From September 2009 to June 2012, 27 cases of bone defect were analyzed retrospectively. The position of bone defect included humerus, radius, ulna, femur, tibia and calcaneus. The range of bone defect was from 0.3 × 1.0 cm to 3 × 6.5 cm. Among them, there were 22 cases with fractures and 5 cases with tumors. All patients were treated with Nano-HA artificial bone. The ability of bone defect repair was evaluated by X-ray exams performed preoperatively and postoperatively. HSS scores were adopted for final evaluation at the latest follow-up.
  
  
  RESULTS
  The patients were followed up from 11 to 26 months (average of 18.5 months). No general side effects occurred. X-ray photo showed an integrity interface between Nano-HA and bone. Primary healing was obtained in all cases without any complication.
  
  
  CONCLUSIONS
  The Nano-HA artificial bone had a good biocompatibility and could be an ideal artificial bone in the reconstruction of bone defect.
authors.affiliation: a Department of Surgery , Guangzhou Medical University , Guangzhou , P. R. China.|b Department of Sports medicine , Shenzhen Second People's Hospital (First Affiliated Hospital of Shenzhen University) , Shenzhen, Guangdong , P. R. China.|c Shenzhen Tissue Engineering Laboratory , Shenzhen , P. R. China.|d Shenzhen Digital Orthopaedic Engineering Laboratory , Shenzhen , P. R. China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhu
authors.affiliation: a Department of Surgery , Guangzhou Medical University , Guangzhou , P. R. China.|b Department of Sports medicine , Shenzhen Second People's Hospital (First Affiliated Hospital of Shenzhen University) , Shenzhen, Guangdong , P. R. China.
authors.forename: Daping
authors.initials: D
authors.lastname: Wang
authors.affiliation: a Department of Surgery , Guangzhou Medical University , Guangzhou , P. R. China.|b Department of Sports medicine , Shenzhen Second People's Hospital (First Affiliated Hospital of Shenzhen University) , Shenzhen, Guangdong , P. R. China.
authors.forename: Jianyi
authors.initials: J
authors.lastname: Xiong
authors.affiliation: c Shenzhen Tissue Engineering Laboratory , Shenzhen , P. R. China.|d Shenzhen Digital Orthopaedic Engineering Laboratory , Shenzhen , P. R. China.
authors.forename: Jianquan
authors.initials: J
authors.lastname: Liu
authors.affiliation: c Shenzhen Tissue Engineering Laboratory , Shenzhen , P. R. China.|d Shenzhen Digital Orthopaedic Engineering Laboratory , Shenzhen , P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: You
authors.affiliation: c Shenzhen Tissue Engineering Laboratory , Shenzhen , P. R. China.|d Shenzhen Digital Orthopaedic Engineering Laboratory , Shenzhen , P. R. China.
authors.forename: Jianghong
authors.initials: J
authors.lastname: Huang
authors.affiliation: c Shenzhen Tissue Engineering Laboratory , Shenzhen , P. R. China.|d Shenzhen Digital Orthopaedic Engineering Laboratory , Shenzhen , P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Duan
authors.affiliation: c Shenzhen Tissue Engineering Laboratory , Shenzhen , P. R. China.|d Shenzhen Digital Orthopaedic Engineering Laboratory , Shenzhen , P. R. China.
authors.forename: Jielin
authors.initials: J
authors.lastname: Chen
authors.affiliation: e Biomechanics Department, Biomechanics and Medical Information Institute , Beijing University of Technology , Beijing , P. R. China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002111:Calcaneus / Q000000981:diagnostic imaging / Q000293:injuries / Q000601:surgery; D002648:Child; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000293:injuries / Q000601:surgery; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging / Q000293:injuries / Q000601:surgery; D008297:Male; D008875:Middle Aged; D049329:Nanostructures / Q000627:therapeutic use*; D011859:Radiography; D011884:Radius / Q000000981:diagnostic imaging / Q000293:injuries / Q000601:surgery; D013977:Tibia / Q000000981:diagnostic imaging / Q000293:injuries / Q000601:surgery; D023822:Tissue Engineering / Q000379:methods; D014457:Ulna / Q000000981:diagnostic imaging / Q000293:injuries / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
chemical_list: D018786:Bone Substitutes; D017886:Durapatite
keywords: artificial bone; bone defect; hydroxyapatite; nano-material