title: Polymorphisms of PRLR and FOLR1 genes and association with milk production traits in goats.
abstract: We investigated the polymorphisms of PRLR and FOLR1 genes in Xinong Saanen, Guanzhong, and Boer goat breeds by DNA sequencing and PCR-RFLP. Two novel SNPs were identified: KC109741: g.62130C>T in the 3ꞌ-UTR of goat gene PRLR, and KC136296: g.7884A>C in exon 3 of goat gene FOLR1. In the three goat breeds, the polymorphism information content was 0.20-0.27 at the g.62130C>T locus. At the g.7884A>C locus, it was 0.36 in Boer goats. The three goat breeds were in Hardy-Weinberg disequilibrium at the g.62130C>T locus. The g.62130C>T SNP was found to be significantly associated with milk production traits in Xinong Saanen and Guanzhong breeds. These results are consistent with the regulatory function of PRLR in mammary gland development, milk secretion, and expression of milk protein genes; they extend the spectrum of genetic variation of the goat PRLR gene, which could be useful for breeding programs.
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: J X
authors.initials: JX
authors.lastname: Hou
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: F
authors.initials: F
authors.lastname: Fang
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: X P
authors.initials: XP
authors.lastname: An
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yan
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: T
authors.initials: T
authors.lastname: Ma
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: P
authors.initials: P
authors.lastname: Han
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: F X
authors.initials: FX
authors.lastname: Meng
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: Y X
authors.initials: YX
authors.lastname: Song
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: J G
authors.initials: JG
authors.lastname: Wang
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China caobinyun@yahoo.com.cn.
authors.forename: B Y
authors.initials: BY
authors.lastname: Cao
mesh_terms: D020413:3' Untranslated Regions; D000818:Animals; D001947:Breeding; D058975:Folate Receptor 1 / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D006041:Goats / Q000235:genetics; D008892:Milk; D020641:Polymorphism, Single Nucleotide; D011981:Receptors, Prolactin / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D020413:3' Untranslated Regions; D058975:Folate Receptor 1; D011981:Receptors, Prolactin