title: Recombinant human platelet-derived growth factor BB for reconstruction of human large extraction site defects.
abstract: This study investigated the ability of growth factor-enhanced matrices combined with a tenting screw scaffolding system and resorbable membrane to regenerate large alveolar extraction site defects. Eight patients were randomized to treatment either with a bovine or equine matrix mixed in a ratio of 1.0 mL (0.3 mg/mL) recombinant human platelet-derived growth factor BB (rh-PDGF-BB) per gram of xenograft and allowed to absorb for 10 minutes. Tenting screws were used to provide additional support, and the growth factor-enhanced particulate matrix was incrementally placed and condensed into the defect and covered by a resorbable membrane. Reentry surgery after 5 months allowed for trephine core biopsies and implant placement. All sites healed well with evidence of bonelike hard tissue that was confirmed histologically as vital bone around the remaining graft particulate in both treatment groups. The results of this study demonstrate the capability of growth factor-enhanced matrices combined with tenting screws and a resorbable membrane to support the reconstruction of large extraction site defects.
authors.forename: Marc L
authors.initials: ML
authors.lastname: Nevins
authors.forename: Mark A
authors.initials: MA
authors.lastname: Reynolds
authors.forename: Marcelo
authors.initials: M
authors.lastname: Camelo
authors.forename: Peter
authors.initials: P
authors.lastname: Schupbach
authors.forename: David M
authors.initials: DM
authors.lastname: Kim
authors.forename: Myron
authors.initials: M
authors.lastname: Nevins
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000601:surgery*; D000818:Animals; D000077214:Becaplermin; D001706:Biopsy; D001863:Bone Screws; D016025:Bone Transplantation; D003758:Dental Implantation, Endosseous / Q000379:methods*; D005260:Female; D017823:Furcation Defects / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal; D006736:Horses; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010510:Periodontal Diseases / Q000601:surgery*; D020574:Proto-Oncogene Proteins c-sis / Q000627:therapeutic use*; D011897:Random Allocation; D054457:Tissue Scaffolds; D014945:Wound Healing
chemical_list: D008567:Membranes, Artificial; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin