title: Synthesis, antifungal activities and qualitative structure activity relationship of carabrone hydrazone derivatives as potential antifungal agents.
abstract: Aimed at developing novel fungicides for relieving the ever-increasing pressure of agricultural production caused by phytopathogenic fungi, 28 new hydrazone derivatives of carabrone, a natural bioactive sesquisterpene, in three types were designed, synthesized and their antifungal activities against Botrytis cinerea and Colletotrichum lagenarium were evaluated. The result revealed that all the derivatives synthesized exhibited considerable antifungal activities in vitro and in vivo, which led to the improved activities for carabrone and its analogues and further confirmed their potential as antifungal agents.
authors.affiliation: Research & Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Northwest A&F University, Xinong Road 22, Yangling 712100, Shaanxi, China. k2wanghao@gmail.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Research & Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Northwest A&F University, Xinong Road 22, Yangling 712100, Shaanxi, China. rensx123@gmail.com.
authors.forename: Shuang-Xi
authors.initials: SX
authors.lastname: Ren
authors.affiliation: Research & Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Northwest A&F University, Xinong Road 22, Yangling 712100, Shaanxi, China. skyhugh2012@gmail.com.
authors.forename: Ze-Yu
authors.initials: ZY
authors.lastname: He
authors.affiliation: Research & Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Northwest A&F University, Xinong Road 22, Yangling 712100, Shaanxi, China. moraldragonwang@gmail.com.
authors.forename: De-Long
authors.initials: DL
authors.lastname: Wang
authors.affiliation: Research & Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Northwest A&F University, Xinong Road 22, Yangling 712100, Shaanxi, China. orgshylock@gmail.com.
authors.forename: Xiao-Nan
authors.initials: XN
authors.lastname: Yan
authors.affiliation: Research & Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Northwest A&F University, Xinong Road 22, Yangling 712100, Shaanxi, China. fengjt67@hotmail.com.
authors.forename: Jun-Tao
authors.initials: JT
authors.lastname: Feng
authors.affiliation: Research & Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Northwest A&F University, Xinong Road 22, Yangling 712100, Shaanxi, China. zhxing1952@126.com.
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020171:Botrytis / Q000187:drug effects* / Q000502:physiology; D020231:Colletotrichum / Q000187:drug effects* / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D018551:Solanum lycopersicum / Q000187:drug effects / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D015394:Molecular Structure; D025282:Mycelium / Q000187:drug effects / Q000502:physiology; D013045:Species Specificity; D013172:Spores, Fungal / Q000187:drug effects / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D006835:Hydrazones