title: Regulation of epidermal cell fate in Arabidopsis roots: the importance of multiple feedback loops.
abstract: The specification of distinct cell types in multicellular organisms is accomplished via establishment of differential gene expression. A major question is the nature of the mechanisms that establish this differential expression in time and space. In plants, the formation of the hair and non-hair cell types in the root epidermis has been used as a model to understand regulation of cell specification. Recent findings show surprising complexity in the number and the types of regulatory interactions between the multiple transcription factor genes/proteins influencing root epidermis cell fate. Here, we describe this regulatory network and the importance of the multiple feedback loops for its establishment and maintenance.
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Michigan Ann Arbor, MI, USA.
authors.forename: John
authors.initials: J
authors.lastname: Schiefelbein
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Michigan Ann Arbor, MI, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Michigan Ann Arbor, MI, USA.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Zheng
keywords: Arabidopsis thaliana; feedback loops; pattern formation; root hairs; transcription factors