title: Primary squamous cell carcinoma of the endometrium in elderly women: a report of four cases.
abstract: Pure squamous cell carcinoma arising in the endometrium represents a rare entity, accounting for <1 % of all endometrial malignancies. Limited data about pathogenetics' and behaviours' features are available. Of consequence, there is no consensus about classification and different therapeutic option. Four cases of elderly patients (aged > 65 years) affected by pure squamous cell carcinoma of the endometrium are presented. Known risk factors for endometrial squamous metaplasia (i.e., pelvic inflammatory disease and cervical stenosis) were observed in two patients. Patients with a disease limited to the uterine corpus had favourable prognosis after surgery ± radiotherapy, while one patient with lymph nodes involvement and another who refused staging and/or adjuvant therapy had recurrent disease. Primary squamous cell carcinoma of the endometrium is rare and aggressive occurrence, characteristic of elderly patients. Radical surgery and adjuvant radiotherapy should be administered.
authors.affiliation: Department of Obstetrics and Gynecology, University of Insubria, Del Ponte Hospital, Piazza Biroldi 1, 21100, Varese, Italy, giorgiobogani@yahoo.it.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bogani
authors.forename: Stefano
authors.initials: S
authors.lastname: Uccella
authors.forename: Antonella
authors.initials: A
authors.lastname: Cromi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Serati
authors.forename: Jvan
authors.initials: J
authors.lastname: Casarin
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Donadello
authors.forename: Fabio
authors.initials: F
authors.lastname: Ghezzi
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007249:Inflammation; D012307:Risk Factors; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D014599:Uterus / Q000378:metabolism