title: Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity.
abstract: We examined 1) whether global cerebral blood flow (CBF) would increase across a 6-h bout of normobaric poikilocapnic hypoxia and be mediated by a larger increase in blood flow in the vertebral artery (VA) than in the internal carotid artery (ICA); and 2) whether additional increases in global CBF would be evident following an α1-adrenergic blockade via further dilation of the ICA and VA. In 11 young normotensive individuals, ultrasound measures of ICA and VA flow were obtained in normoxia (baseline) and following 60, 210, and 330 min of hypoxia (FiO2 = 0.11). Ninety minutes prior to final assessment, participants received an α1-adrenoreceptor blocker (prazosin, 1 mg/20 kg body mass) or placebo. Compared with baseline, following 60, 220, and 330 min of hypoxia, global CBF [(ICAFlow + VAFlow) ∗ 2] increased by 160 ± 52 ml/min (+28%; P = 0.05), 134 ± 23 ml/min (+23%; P = 0.02), and 113 ± 51 (+19%; P = 0.27), respectively. Compared with baseline, ICAFlow increased by 23% following 60 min of hypoxia (P = 0.06), after which it progressively declined. The percentage increase in VA flow was consistently larger than ICA flow during hypoxia by ∼20% (P = 0.002). Compared with baseline, ICA and VA diameters increased during hypoxia by ∼9% and ∼12%, respectively (P ≤ 0.05), and were correlated with reductions in SaO2. Flow and diameters were unaltered following α1 blockade (P ≥ 0.10). In conclusion, elevations in global CBF during acute hypoxia are partly mediated via greater increases in VA flow compared with ICA flow; this regional difference was unaltered following α1 blockade, indicating that a heightened sympathetic nerve activity with hypoxia does not constrain further dilation of larger extracranial blood vessels.
authors.affiliation: Centre for Heart, Lung and Vascular Health, University of British Columbia, Kelowna, British Columbia, Canada.
authors.forename: Nia C S
authors.initials: NC
authors.lastname: Lewis
authors.forename: Laura
authors.initials: L
authors.lastname: Messinger
authors.forename: Brad
authors.initials: B
authors.lastname: Monteleone
authors.forename: Philip N
authors.initials: PN
authors.lastname: Ainslie
mesh_terms: D000208:Acute Disease; D000320:Adrenergic Fibers / Q000187:drug effects / Q000502:physiology*; D058671:Adrenergic beta-1 Receptor Antagonists / Q000494:pharmacology; D000328:Adult; D002343:Carotid Artery, Internal / Q000187:drug effects / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014711:Vertebral Artery / Q000187:drug effects / Q000502:physiology*; D055815:Young Adult
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists
keywords: hypoxia; vasculature; α1-adrenoreceptor