title: Lack of significant effects of Chlamydia trachomatis infection on cervical cancer risk in a nested case-control study in North-East Thailand.
abstract: Cervical cancer continues to be an important public health problem in Thailand. While the high risk human papillomavirus (HPV) types have been established as the principle causative agent of both malignancies and the precursor lesions, cervical intraepithelial neoplasia (CIN), other factors may also be involved like other sexually transmitted diseases, as well as smoking. Chlamydia trachomatis is an obligate intracellular Gram-negative bacterium which has a tendency to cause chronic infection featuring inflammation and therefore might be expected to increase the risk of cervical cancer. In the present nested case-control study, 61 cases of cervical cancer and 288 matched controls with original serum samples were identified from the Khon Kaen Cohort, established in the North-East of Thailand, by linkage to the Khon Kaen population based cancer registry. C. trachomatis specific IgG antibodies at recruitment were measured by microimmunofluorescence and assessed for association with cervical cancer using STATA release10. No significant link was noted either with all cancers or after removal of adenocarcinomas. The results suggest no association between Chlamydia infection and cervical cancer development in North-East Thailand, but possible influencing factors must be considered in any future research on this topic.
authors.affiliation: Department of Epidemiology, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand E-mail : naowtu@kku.ac.th.
authors.forename: Naowarat
authors.initials: N
authors.lastname: Tungsrithong
authors.forename: Chananya
authors.initials: C
authors.lastname: Kasinpila
authors.forename: Chanwit
authors.initials: C
authors.lastname: Maneenin
authors.forename: Proscovia B
authors.initials: PB
authors.lastname: Namujju
authors.forename: Matti
authors.initials: M
authors.lastname: Lehtinen
authors.forename: Ahti
authors.initials: A
authors.lastname: Anttila
authors.forename: Supannee
authors.initials: S
authors.lastname: Promthet
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000453:epidemiology* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D012306:Risk; D012307:Risk Factors; D012749:Sexually Transmitted Diseases / Q000453:epidemiology; D013785:Thailand; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000382:microbiology; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G