title: Improved lipid profile and increased serum antioxidant capacity in healthy volunteers after Sambucus ebulus L. fruit infusion consumption.
abstract: This study aimed to establish the effect of Sambucus ebulus L. (SE) ripe fruit infusion on body weight, blood pressure, glucose levels, lipid profile and antioxidant markers in healthy volunteers in respect of its possible protective activity against cardiovascular diseases and other oxidative stress-related diseases. The study involved 21 healthy volunteers, aged between 20 and 59, BMI 23.12 ± 1.31, who consumed 200 ml SE infusion/day for a period of 30 d. Blood samples were collected before and at the end of the intervention. Significant decrease in triglycerides (14.92%), total cholesterol (15.04%) and LDL-C (24.67%) was established at the end of the study. In addition, HDL-C/LDL-C ratio increased by 42.77%. Improved serum antioxidant capacity and total thiol levels were also established. The results presented in this first human intervention study with SE fruit infusion indicate the potential of the plant to improve lipid profile and serum antioxidant capacity in humans.
authors.affiliation: Department of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University Varna , Varna , Bulgaria.
authors.forename: Diana
authors.initials: D
authors.lastname: Ivanova
authors.forename: Oskan
authors.initials: O
authors.lastname: Tasinov
authors.forename: Yoana
authors.initials: Y
authors.lastname: Kiselova-Kaneva
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005638:Fruit; D064368:Healthy Volunteers; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D027923:Sambucus; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol
keywords: Hypolipidemic; LDL-cholesterol; medicinal plant; total cholesterol; total thiols; triglycerides