title: Plasma levels of S100B in preeclampsia and association with possible central nervous system effects.
abstract: BACKGROUND
  S100B is supposed to be a peripheral biomarker of central nervous system (CNS) injury. The purpose of this study was to compare levels of S100B in women with preeclampsia with levels in healthy pregnant control subjects and furthermore to analyze levels of S100B in relation to possible CNS effects.
  
  
  METHODS
  A cross-sectional case-control study in antenatal care centers in Uppsala, Sweden, was performed. Fifty-three women with preeclampsia and 58 healthy pregnant women were recruited at similar gestational length; women with preeclampsia were recruited at time of diagnosis, and control subjects were recruited during their routine visit to an antenatal clinic. Plasma samples were collected, and levels of S100B were analyzed with an enzyme-linked immunosorbent assay. Information about demographic and clinical characteristics, including symptoms related to CNS affection, was collected from the medical records. The main outcome measures were plasma levels of S100B and possible CNS effects.
  
  
  RESULTS
  Levels of S100B were significantly higher among women with preeclampsia than among control subjects (0.12 µg/L vs. 0.07 µg/L; P < 0.001). In preeclampsia, there was a significant association between high levels of S100B and visual disturbances (P < 0.05).
  
  
  CONCLUSIONS
  S100B is increased among women with preeclampsia, and high levels of S100B associate with visual disturbances, which might reflect CNS affection in women with preeclampsia.
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Centre for Clinical Research, Dalarna, Sweden; lina.bergman@kbh.uu.se.
authors.forename: Lina
authors.initials: L
authors.lastname: Bergman
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden;
authors.forename: Tansim
authors.initials: T
authors.lastname: Akhter
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden;
authors.forename: Anna-Karin
authors.initials: AK
authors.lastname: Wikström
authors.affiliation: Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Wikström
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden;
authors.forename: Tord
authors.initials: T
authors.lastname: Naessen
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden;
authors.forename: Helena
authors.initials: H
authors.lastname: Åkerud
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002490:Central Nervous System / Q000293:injuries*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D009460:Neurologic Examination; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011256:Pregnancy Outcome; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D014786:Vision Disorders / Q000209:etiology
chemical_list: D015415:Biomarkers; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human
keywords: S100B; blood pressure; hypertension; neurological dysfunction; preeclampsia