title: The Region Centromeric to HLA-C Is a Key Region for Understanding the Phenotypic Variability of Psoriatic Arthritis.
abstract: With the aim of clarifying the role of several polymorphisms around the HLA-C locus in the clinical expression of PsA, the distribution of several polymorphic markers and genes located around the HLA-C locus was analyzed in a well-established cohort of 110 patients with PsA, 50 patients with psoriasis alone, and 110 healthy controls. The frequency of these genes was also analyzed by PsA articular models, based on three main subgroups: oligoarthritis, polyarthritis, and spondylitis. Distal interphalangeal joint (DIP) involvement was associated with the presence of MICB-CA20 (OR 6.0, 95% CI: 1.58-22.69, P = 0.005). HLA-DRB∗07 was associated with oligoarticular forms of PsA (OR 4.1, 95% CI: 1.8-9.3, P = 0.0007). The spondylitic forms overexpressed the antigen HLA-B∗27 (OR 5.7, 95% CI: 2.4-13.6, P = 0.0001). MICA-A5.1 showed association with polyarthritis (OR 3.7, 95% CI: 1.5-8.8, P = 0.006). Genes telomeric to HLA-C were overexpressed in psoriasis but not in PsA subphenotypes. This study shows that the region centromeric to HLA-C is a key region that expresses not only disease risk genes but also genes that help explain the phenotypic variability of PsA.
authors.affiliation: Rheumatology Department, Hospital Universitario Central de Asturias (HUCA), C/Celestino Villamil S/N, 33006 Oviedo, Spain.
authors.forename: Rubén
authors.initials: R
authors.lastname: Queiro
authors.affiliation: Rheumatology Department, Hospital Universitario Central de Asturias (HUCA), C/Celestino Villamil S/N, 33006 Oviedo, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Tejón
authors.affiliation: Rheumatology Department, Hospital Universitario Central de Asturias (HUCA), C/Celestino Villamil S/N, 33006 Oviedo, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Alonso
authors.affiliation: Dermatology Department, HUCA, C/Celestino Villamil S/N, 33006 Oviedo, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Coto
authors.affiliation: Immunology Department, Histocompatibility Unit, HUCA, C/Celestino Villamil S/N, 33006 Oviedo, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: López-Larrea
authors.affiliation: Immunology Department, Histocompatibility Unit, HUCA, C/Celestino Villamil S/N, 33006 Oviedo, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Martínez-Borra
authors.affiliation: Department of Functional Biology, IUOPA, University of Oviedo, C/Celestino Villamil S/N, 33006 Oviedo, Spain.
authors.forename: Segundo
authors.initials: S
authors.lastname: González