title: Zn(II)-curcumin protects against hemorheological alterations, oxidative stress and liver injury in a rat model of acute alcoholism.
abstract: Curcumin can chelate metal ions, forming metallocomplexes. We compared the effects of Zn(II)-curcumin with curcumin against hemorheological alterations, oxidative stress and liver injury in a rat model of acute alcoholism. Oral administration of Zn(II)-curcumin dose-dependently prevented the ethanol-induced elevation of serum malondialdehyde (MDA) content and reductions in glutathione level and superoxide dismutase (SOD) activity. Zn(II)-curcumin also inhibited ethanol-induced liver injury. Additionally, Zn(II)-curcumin dose-dependently inhibited hemorheological abnormalities, including the ethanol-induced elevation of whole blood viscosity, plasma viscosity, blood viscosity at corrected hematocrit (45%), erythrocyte aggregation index, erythrocyte rigidity index and hematocrit. Compared to curcumin at the same dose, Zn(II)-curcumin more effectively elevated SOD activity, ameliorated liver injury and improved hemorheological variables. These results suggest that Zn(II)-curcumin protected the rats from ethanol-induced liver injury and hemorheological abnormalities via the synergistic effect of curcumin and zinc.
authors.affiliation: Laboratory of Traditional Chinese Medicine and Marine Drugs, Department of Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Yu
authors.affiliation: Laboratory of Traditional Chinese Medicine and Marine Drugs, Department of Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Xue-Ting
authors.initials: XT
authors.lastname: Mei
authors.affiliation: Laboratory of Traditional Chinese Medicine and Marine Drugs, Department of Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Zheng
authors.affiliation: Laboratory of Traditional Chinese Medicine and Marine Drugs, Department of Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. Electronic address: Donghuixu007@163.com.
authors.forename: Dong-Hui
authors.initials: DH
authors.lastname: Xu
mesh_terms: D000437:Alcoholism / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004903:Erythrocyte Aggregation / Q000187:drug effects; D000431:Ethanol; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006400:Hematocrit; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D020011:Protective Agents; D000431:Ethanol; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005723:gamma-Glutamyltransferase; D005978:Glutathione; D003474:Curcumin; D015032:Zinc
keywords: Alcohol; Hemorheology; Liver injury; Oxidative stress; Zn(II)–curcumin