title: Measuring soluble biomarkers in clinical trials: do tiered approaches to the analysis and validation of assays provide an answer to the fit-for-purpose challenge?
authors.affiliation: A4P Consulting Limited, Innovation House, Discovery Park, Sandwich, Kent, CT13 9NJ, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Hucker
authors.forename: Carl
authors.initials: C
authors.lastname: Watson
authors.forename: Ian
authors.initials: I
authors.lastname: James
authors.forename: Scott
authors.initials: S
authors.lastname: Vincent
authors.forename: David
authors.initials: D
authors.lastname: Muirhead
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D002986:Clinical Trials as Topic / Q000379:methods* / Q000592:standards; D006801:Humans; D015203:Reproducibility of Results; D012995:Solubility
chemical_list: D015415:Biomarkers