title: Translational research in pancreatic adenocarcinoma.
abstract: Pancreatic cancer is ranked as the fourth leading cause of cancer-related deaths in the United States despite intensive basic and clinical research over the last decade. In this paper we summarize the Abstracts #176, #234, and #206 presented at the 2014 ASCO Gastrointestinal Cancers Symposium focussing on BRCA 1 and 2 mutations, PABL gene mutations and expression of microRNAs to matrix metalloproteinase. There is an intense need for new findings in the translational research field with prognostic, predictive and therapeutic value.
authors.affiliation: Section of GI Cancers and Experimental Therapeutics, Tufts University School of Medicine. Boston, MA, USA. Gkaur@tuftsmedicalcenter.org.
authors.forename: Gurbakhash
authors.initials: G
authors.lastname: Kaur
authors.forename: Muhammad Wasif
authors.initials: MW
authors.lastname: Saif
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein / Q000235:genetics; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D011379:Prognosis; D057170:Translational Research, Biomedical / Q000379:methods* / Q000639:trends*
chemical_list: D019313:BRCA1 Protein; D024682:BRCA2 Protein; D035683:MicroRNAs; D020782:Matrix Metalloproteinases