title: Expression of regulatory T and helper T cells in peripheral blood of patients with pregnancy-induced hypertension.
abstract: OBJECTIVE
  To analyze the expression of regulatory T cells and helper T cells in peripheral blood of patients with pregnancy-induced hypertension (PIH).
  
  
  METHODS
  Twenty-seven patients hospitalized with PIH were consecutively collected for detection of regulatory T cells (CD4+ CD25+ Treg and CD4+ CD25+ Foxp3+Treg) and helper T (CD+3, CD+4, CD+8, CD+4/CD+8) cells in peripheral blood. Meanwhile, 20 normal hospitalized pregnant women served as the control group.
  
  
  RESULTS
  In the comparison of regulatory T cells, the level of serum CD4+ CD25+ Treg and CD4+ CD25+ Foxp3+Treg in PIH group was significantly lower than control group (all p < 0.05). In the comparison of help T cells, the expression level of serum CD+4/CD+8 in PIH group was obviously higher than control group, while the expression level of CD+8 was significantly lower than control group (all p < 0.05).
  
  
  CONCLUSIONS
  There were obvious abnormal expressions of regulatory T cell and helper T cells in peripheral blood of patients with PIH.
authors.affiliation: Department of Obstetrics, The Fourth Affiliated Hospital of China Medical University, Shenyang City, Liaoning Provence, China. yanzhaocn@163.com
authors.forename: X
authors.initials: X
authors.lastname: Cao
authors.affiliation: Department of Obstetrics, The Fourth Affiliated Hospital of China Medical University, Shenyang City, Liaoning Provence, China.
authors.forename: L L
authors.initials: LL
authors.lastname: Wang
authors.affiliation: Department of Obstetrics, The Fourth Affiliated Hospital of China Medical University, Shenyang City, Liaoning Provence, China.
authors.forename: X
authors.initials: X
authors.lastname: Luo
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000276:immunology*; D053645:Interleukin-2 Receptor alpha Subunit / Q000032:analysis; D018655:Lymphocyte Count; D011247:Pregnancy; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit