title: Stereotactic radiosurgery in intraocular malignant melanoma--retrospective study.
abstract: OBJECTIVE
  One day session linear accelerator based stereotactic radiosurgery of intraocular malignant melanoma is a method of "conservative" attitude to treat posterior uveal melanoma.
  
  
  METHODS
  Retrospective clinic-based study of patients with posterior uveal melanoma in stage T2/T3 who underwent stereotactic radiosurgery at linear accelerator in period 2001-2011. Immobilization of the affected eye was achieved by mechanical fixation to the stereotactic Leibinger frame. The stereotactic treatment planning after fusion of computed tomography and magnetic resonance imaging was optimized according to the critical structures (lenses, optic nerves, chiasm).
  
  
  RESULTS
  In group of 96 patients with posterior uveal melanoma treated with one day session stereotactic radiosurgery, patient age ranged from 25 to 80 years with a median of 54 years. Median tumor volume at baseline was 0.6 cm(3) (with range from 0.2 to 1.0 cm(3)). Median maximal dose applied was 49.0 Gy (range from 37.0 to 52.0 Gy). Secondary enucleation was necessary in 11 patients (11.5%) due to complications like irradiation neuropathy and secondary glaucoma. Tumor local control was successful in 95% of patients in 3 years interval after stereotactic radiosurgery and in 85% of patients in 5 years interval after stereotactic radiosurgery.
  
  
  CONCLUSIONS
  One step LINAC based stereotactic radiosurgery with a single dose 35.0 Gy is one of treatment options to treat T2 or T3 stage posterior uveal melanoma.
authors.affiliation: Department of Ophthalmology, Medical School, Comenius University, Bratislava, Slovakia. afrf@mail.t-com.sk; alikafurdova@gmail.com.
authors.forename: Alena
authors.initials: A
authors.lastname: Furdova
authors.affiliation: Department of Stereotactic Radiosurgery, St. Elisabeth Cancer Inst. and St. Elisabeth University College of Health and Social Work, Bratislava, Slovakia.
authors.forename: Miron
authors.initials: M
authors.lastname: Sramka
authors.affiliation: Department of Stereotactic Radiosurgery, St. Elisabeth Cancer Inst. and St. Elisabeth University College of Health and Social Work, Bratislava, Slovakia.
authors.forename: Martin
authors.initials: M
authors.lastname: Chorvath
authors.affiliation: Department of Stereotactic Radiosurgery, St. Elisabeth Cancer Inst. and St. Elisabeth University College of Health and Social Work, Bratislava, Slovakia.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Kralik
authors.affiliation: Department of Ophthalmology, Medical School, Comenius University, Bratislava, Slovakia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Krasnik
authors.affiliation: Department of Ophthalmology, Medical School, Comenius University, Bratislava, Slovakia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Krcova
authors.affiliation: Division of Biomedical Physics, Faculty of Mathematics, Physics and Informatics, Comenius University, Bratislava, Slovakia.
authors.forename: Iveta
authors.initials: I
authors.lastname: Waczulikova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D064847:Multimodal Imaging; D060787:Neoplasm Grading; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D047368:Tumor Burden; D014604:Uveal Neoplasms / Q000473:pathology / Q000601:surgery*