title: Iron-catalyzed aerobic difunctionalization of alkenes: a highly efficient approach to construct oxindoles by C-S and C-C bond formation.
abstract: A novel iron-catalyzed efficient approach to construct sulfone-containing oxindoles, which play important roles in the structural library design and drug discovery, has been developed. The use of readily available benzenesulfinic acids, an inexpensive iron salt as the catalyst, and air as the oxidant makes this sulfur incorporation protocol very efficient and practical.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Rd. 38, Beijing 100191, People's Republic of China. jiaoning@bjmu.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Shen
authors.forename: Yizhi
authors.initials: Y
authors.lastname: Yuan
authors.forename: Song
authors.initials: S
authors.lastname: Song
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao
mesh_terms: D000388:Air; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry; D000078183:Oxindoles; D010100:Oxygen / Q000737:chemistry; D013441:Sulfinic Acids / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry
chemical_list: D000475:Alkenes; D007211:Indoles; D016877:Oxidants; D000078183:Oxindoles; D013441:Sulfinic Acids; D013450:Sulfones; C022960:2-oxindole; C425152:benzenesulfinic acid; D007501:Iron; D010100:Oxygen