title: Epidemiology of snakebite and use of antivenom in Argentina.
abstract: BACKGROUND
  The incidence and case fatality rate of snakebite in Argentina are poorly known.
  
  
  METHODS
  The authors used questionnaires provided with antivenoms by the primary manufacturer of anti-venoms in Argentina.
  
  
  RESULTS
  A total of 8083 completed questionnaires was collected between 1978 and 1998. The annual incidence of snakebite was 1.8 bites per 100,000 inhabitants, with a high geographical heterogeneity; in the northern provinces of the country, the incidence can exceed 150 snakebites per 100,000 people per year. Bothrops (pit viper) bites predominated, accounting for 96.6% (6720/6957) of envenomations, bites from Crotalus (rattlesnake) accounted for 2.8% (195/6957), and bites from Micrurus (coral snake) for 0.6% (42/6957). Most patients were young men, who were generally bitten during agricultural activities, i.e. while working in the fields. Most snakebites (78.9%, 5852/7419) were to the lower limb, including 58.3% (4322/7419) to the foot. The case fatality rate was <0.04% (3/8083). Most envenomations (90%, 7275/8083) were treated with specific antivenom during the first 4 h after the bite. The median dose of antivenom was two vials for viper bites (Bothrops and Crotalus) and three vials for Micrurus bites.
  
  
  CONCLUSIONS
  These preliminary results should enable manufacturers to increase the availability of appropriate antivenom and health authorities to improve the management of snakebites where they are most common.
authors.affiliation: Departamento de Vacunas y Sueros, INPB-ANLIS 'Dr Carlos G. Malbrán', Ministerio de Salud, Argentina.
authors.forename: Jorge Adrián
authors.initials: JA
authors.lastname: Dolab
authors.forename: Adolfo Rafael
authors.initials: AR
authors.lastname: de Roodt
authors.forename: Ernesto Horacio
authors.initials: EH
authors.lastname: de Titto
authors.forename: Susana Isabel
authors.initials: SI
authors.lastname: García
authors.forename: Raúl
authors.initials: R
authors.lastname: Funes
authors.forename: Oscar Danie
authors.initials: OD
authors.lastname: Salomón
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Chippaux
mesh_terms: D000818:Animals; D000997:Antivenins / Q000008:administration & dosage*; D001118:Argentina / Q000453:epidemiology; D017837:Bothrops; D017839:Crotalus; D004334:Drug Administration Schedule; D017815:Elapidae; D004636:Emergency Service, Hospital / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D012621:Seasons; D012909:Snake Bites / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000997:Antivenins
keywords: Antivenom; Argentina; Bothrops; Crotalus; Micrurus; Snakebite