title: Are newly discovered drivers of immune-mediated skin disorders expressed in normal skin regenerating from standardized surface injury?
abstract: BACKGROUND
  In healthy skin, tape stripping induces a transient wave of histological changes resembling immune-mediated skin diseases, such as psoriasis. The response to surface trauma may harbor mechanisms which are also relevant to the development of Koebner-positive skin disorders. However, studies on newly discovered drivers of inflammation in regenerative skin are lacking.
  
  
  METHODS
  The course of epidermal proliferation and keratinization as well as key representatives of innate and acquired immunity were studied during the first 72 h after tape stripping.
  
  
  RESULTS
  Epidermal rupture rapidly activates various epidermal processes, which remain upregulated for 72 h. Elastase+ and IL-17+ cells dominate the acute phase and their numbers decrease rapidly thereafter. The number of T-Bet+ cells increases more gradually, reaching maximum levels several hours later when the other cell types decrease.
  
  
  CONCLUSIONS
  This model permits investigations on the sequence of crucial inflammatory processes set off by cutaneous injury, which are presumed to play a role within the pathogenesis of immune-mediated skin diseases exhibiting the Koebner phenomenon.
authors.affiliation: Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Anke G M
authors.initials: AG
authors.lastname: Hendriks
authors.forename: Romy R M C
authors.initials: RR
authors.lastname: Keijsers
authors.forename: Marieke M B
authors.initials: MM
authors.lastname: Seyger
authors.forename: Piet E J
authors.initials: PE
authors.lastname: van Erp
authors.forename: Peter C M
authors.initials: PC
authors.lastname: van de Kerkhof
mesh_terms: D056704:Adaptive Immunity / Q000502:physiology; D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D049109:Cell Proliferation; D003880:Dermatology / Q000379:methods; D004817:Epidermis / Q000276:immunology* / Q000473:pathology*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000166:cytology* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012038:Regeneration / Q000502:physiology*; D012867:Skin / Q000293:injuries*; D012871:Skin Diseases / Q000276:immunology*; D018709:Statistics, Nonparametric; D055815:Young Adult