title: [Colorectal cancer (CCR): genetic and molecular alterations].
abstract: The aim of this review is to present a genetic and molecular overview of colorectal carcinogenesis (sporadic and hereditary origin) as a multistage process, where there are a number of molecular mechanisms associated with the development of colorectal cancer and genomic instability that allows the accumulation of mutations in proto-oncogenes and tumor suppressor genes, chromosomal instability, and methylation and microsatellite instability, and the involvement of altered expression of microRNAs' prognosis factors.
authors.affiliation: Universidad de Guadalajara, Guadalajara, Jal. mareynoso77@yahoo.com.mx.
authors.forename: Clara Ibet
authors.initials: CI
authors.lastname: Juárez-Vázquez
authors.forename: Mónica Alejandra
authors.initials: MA
authors.lastname: Rosales-Reynoso
mesh_terms: D063646:Carcinogenesis / Q000235:genetics; D043171:Chromosomal Instability / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics*; D019175:DNA Methylation; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D053842:Microsatellite Instability; D009154:Mutation; D011519:Proto-Oncogenes / Q000235:genetics
chemical_list: D035683:MicroRNAs