title: Determination of the best prognostic value of serum tumor markers in patients with suspected lung cancer in an Iranian population.
abstract: BACKGROUND
  Finding a suitable marker with high sensitivity and specificity for early diagnosis of cancer is very desirable. This study was aimed to determine the diagnostic value of serum CYFRA21-1, carcinoembryonic antigen (CEA), and neuron-specific enolase (NSE) for screening of lung cancer patients in western Iran.
  
  
  METHODS
  This descriptive analytical case-control study was performed on 30 subjects with malignant and 81 with benign lung cancer. Serum levels of CYFRA21-1, CEA, and NSE were determined.
  
  
  RESULTS
  The concentration of serum tumor markers was significantly higher in the malignant group than in the benign subjects. The highest sensitivity was obtained by measurement of serum NSE (73%). The highest specificity was obtained by measurement of serum CYFRA21-1 (95%).
  
  
  CONCLUSIONS
  Our results demonstrate the usefulness of measuring CYFRA21-1 and NSE together for early screening of lung cancer in western Iran.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
authors.forename: Naseh
authors.initials: N
authors.lastname: Sigari
authors.affiliation: Department of Infectious Diseases, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Mohsenpour
authors.affiliation: Department of Pathology and Clinical Laboratory Sciences, Faculty of Para Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
authors.forename: Bahram
authors.initials: B
authors.lastname: Nikkhoo
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
authors.forename: Bayazid
authors.initials: B
authors.lastname: Ghaderi
authors.affiliation: Department of Community Medicine, Kurdistan University Research Center for Gastroenterology and Liver Disease, Kurdistan University of Medical Sciences, Sanandaj, Iran.
authors.forename: Abdolrahim
authors.initials: A
authors.lastname: Afkhamzadeh
authors.affiliation: Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
authors.forename: Namam-Ali
authors.initials: NA
authors.lastname: Azadi
authors.affiliation: Center for Cellular and Molecular Research, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
authors.forename: Fardin
authors.initials: F
authors.lastname: Fathi
authors.affiliation: Department of Pathology and Clinical Laboratory Sciences, Faculty of Para Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdi
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007492:Iran; D053539:Keratin-19 / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011379:Prognosis; D012680:Sensitivity and Specificity
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; C102012:antigen CYFRA21.1; D010751:Phosphopyruvate Hydratase