title: Calcium orthophosphate coatings on magnesium and its biodegradable alloys.
abstract: Biodegradable metals have been suggested as revolutionary biomaterials for bone-grafting therapies. Of these metals, magnesium (Mg) and its biodegradable alloys appear to be particularly attractive candidates due to their non-toxicity and as their mechanical properties match those of bones better than other metals do. Being light, biocompatible and biodegradable, Mg-based metallic implants have several advantages over other implantable metals currently in use, such as eliminating both the effects of stress shielding and the requirement of a second surgery for implant removal. Unfortunately, the fast degradation rates of Mg and its biodegradable alloys in the aggressive physiological environment impose limitations on their clinical applications. This necessitates development of implants with controlled degradation rates to match the kinetics of bone healing. Application of protective but biocompatible and biodegradable coatings able to delay the onset of Mg corrosion appears to be a reasonable solution. Since calcium orthophosphates are well tolerated by living organisms, they appear to be the excellent candidates for such coatings. Nevertheless, both the high chemical reactivity and the low melting point of Mg require specific parameters for successful deposition of calcium orthophosphate coatings. This review provides an overview of current coating techniques used for deposition of calcium orthophosphates on Mg and its biodegradable alloys. The literature analysis revealed that in all cases the calcium orthophosphate protective coatings both increased the corrosion resistance of Mg-based metallic biomaterials and improved their surface biocompatibility.
authors.affiliation: Kudrinskaja sq. 1-155, Moscow 123242, Russia. Electronic address: sedorozhkin@yandex.ru.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Dorozhkin
mesh_terms: D000497:Alloys; D002130:Calcium Phosphates / Q000737:chemistry*; D020099:Coated Materials, Biocompatible; D008274:Magnesium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C020243:calcium phosphate; D008274:Magnesium
keywords: Biodegradable alloys; Calcium orthophosphates; Coatings; Hydroxyapatite; Magnesium