title: Topical nitroglycerin in neonates with tissue injury: A case report and review of the literature.
abstract: Peripheral tissue injury is one of the well-described morbidities associated with stays in the neonatal intensive care unit. Despite the potential long-term disability associated with this event, the current available therapeutic options remain very limited. Topical nitroglycerin has emerged as a promising agent for the treatment of tissue injury in infants. The present article includes a review of the currently available evidence on the use of topical nitroglycerin in the neonatal population, and describes a unique case involving successful use of 2% nitroglycerin in the late treatment of prolonged tissue ischemia in a newborn infant.
authors.affiliation: Division of Paediatric Clinical Pharmacology, Children's National Medical Center;
authors.forename: Samira
authors.initials: S
authors.lastname: Samiee-Zafarghandy
authors.affiliation: Division of Paediatric Clinical Pharmacology, Children's National Medical Center; ; Departments of Pediatrics, Pharmacology, Physiology and Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington DC, USA;
authors.forename: Johannes N
authors.initials: JN
authors.lastname: van den Anker
authors.affiliation: Department of Neonatal-Perinatal Medicine, Children's Hospital of Eastern Ontario, Ottawa, Ontario.
authors.forename: Nadya
authors.initials: N
authors.lastname: Ben Fadel
keywords: Infants; Tissue injury; Topical nitroglycerin