title: Concurrent urothelial carcinoma in the renal pelvis of an allograft kidney and native recipient bladder: evidence of donor origin.
abstract: A 44-year-old woman was admitted to the hospital for asymptomatic gross hematuria. At the age of 28, she underwent transplantation of a kidney from her father for end-stage renal disease secondary to rapidly progressive glomerulonephritis. She resumed peritoneal dialysis when the allograft kidney stopped functioning at the age of 42. Dialysis was continued for the next 2 years, when the hematuria occurred and she was readmitted. Radiologic evaluation and transurethral resection of the bladder tumor revealed a tumor of the renal pelvis of the allograft kidney (cT3N0M0) and multiple bladder tumors (cT1N0M0). Total cystectomy and allograft nephroureterectomy were performed. Histopathological examinations revealed high grade urothelial carcinoma in the renal pelvis of the allograft kidney (pT3) and native bladder (pT1). Fluorescence in situ hybridization of both specimens demonstrated that the renal pelvic tumors and bladder cancer possessed XY karyotypes. These results indicated that the urothelial carcinoma developed de novo in the renal pelvis of the allograft kidney and was implanted into the recipient's native bladder.
authors.affiliation: *Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba City, Ibaraki 305-8575, Japan. nishiuro@md.tsukuba.ac.jp.
authors.forename: Ei-ichiro
authors.initials: E
authors.lastname: Takaoka
authors.forename: Jun
authors.initials: J
authors.lastname: Miyazaki
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Kimura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kojima
authors.forename: Koji
authors.initials: K
authors.lastname: Kawai
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Murata
authors.forename: Naoe
authors.initials: N
authors.lastname: Itoguchi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Minami
authors.forename: Takako
authors.initials: T
authors.lastname: Nakamura
authors.forename: Katsuya
authors.initials: K
authors.lastname: Honda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nishiyama
mesh_terms: D000328:Adult; D064591:Allografts; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D015653:Cystectomy; D018450:Disease Progression; D005220:Fathers; D005260:Female; D005921:Glomerulonephritis / Q000150:complications; D006417:Hematuria / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery* / Q000628:therapy; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D007682:Kidney Pelvis / Q000473:pathology / Q000601:surgery; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009392:Nephrectomy; D009679:Nuclear Family; D006435:Renal Dialysis; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D007166:Immunosuppressive Agents
keywords: allograft kidney; fluorescence in situ hybridization; implantation; urothelial carcinoma