title: MYC, MAX, and small cell lung cancer.
abstract: In this issue of Cancer Discovery, Romero and colleagues identify somatic mutations and deletions of MAX, and also define what seem to be mutually exclusive alterations in MYC family members and other MYC-associated factors in small cell lung cancer. Taken together, these data highlight the importance of MYC signaling in small cell lung cancer and suggest possible avenues for therapeutic intervention.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, New York, New York.
authors.forename: Charles M
authors.initials: CM
authors.lastname: Rudin
authors.forename: J T
authors.initials: JT
authors.lastname: Poirier
mesh_terms: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics*; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D004265:DNA Helicases / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D009687:Nuclear Proteins / Q000378:metabolism*; D055752:Small Cell Lung Carcinoma / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D051792:Basic Helix-Loop-Helix Proteins; D004265:DNA Helicases; D009687:Nuclear Proteins; D014157:Transcription Factors; C499330:MAX protein, human; C584050:MGA protein, human; C084108:SMARCA4 protein, human