title: Synthesis and biological evaluation of novel N' (4-aryloxybenzylidene)- 1H-benzimidazole-2 carbohydrazide derivatives as anti-tubercular agents.
abstract: A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using Resazurin Microtiter assay (REMA) method. These compounds showed good antituberculosis activity with minimum inhibitory concentration (MIC) value of the range of 1.5-25 µg/mL.
authors.forename: Afsar Ali
authors.initials: AA
authors.lastname: Siddiki
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Bairwa
authors.affiliation: Institute of Chemical Technology, Department of Pharmaceutical Sciences and Technology, Mumbai 400 019, India. vikastelvekar@rediffmail.com.
authors.forename: Vikas N
authors.initials: VN
authors.lastname: Telvekar
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D001562:Benzimidazoles; D006834:Hydrazines; C019289:carbohydrazide