title: Immune response of pigs to Salmonella enterica serovar Derby and Typhimurium infections.
abstract: Interaction between pigs and Salmonella enterica serovar Derby (Salmonella Derby) is much less understood in comparison with Salmonella enterica serovar Typhimurium (Salmonella Typhimurium). To study interactions of weaned piglets with Salmonella Derby, we compared the course of infections with Salmonella Derby De1 and Salmonella Typhimurium DT104 strains, both isolated from pig herds with a long history of asymptomatic infection. Salmonella Derby strain used was shed during the 28-day experiment period, while Salmonella Typhimurium strain was not found in faeces after day 17 post-infection. When the piglets were co-infected with both strains, Salmonella Derby was present in faeces until the end of the experiment, whilst Salmonella Typhimurium disappeared after day 21 post-infection. At the end of the experiment, Salmonella Derby was present in more tissues when compared with Salmonella Typhimurium. Piglets infected with Salmonella Typhimurium responded earlier with synthesis of anti-lipopolysaccharide IgM and IgG antibodies and with higher antibody levels compared to piglets infected with Salmonella Derby. Cellular immune response to both strains was very low and was detected later than was the onset of IgG antibody production.
authors.affiliation: Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic. Electronic address: matiasovic@vri.cz.
authors.forename: Jan
authors.initials: J
authors.lastname: Matiasovic
authors.affiliation: Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Stepanova
authors.affiliation: Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Kudlackova
authors.affiliation: Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Havlickova
authors.affiliation: Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
authors.forename: Frantisek
authors.initials: F
authors.lastname: Sisak
authors.affiliation: Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
authors.forename: Ivan
authors.initials: I
authors.lastname: Rychlik
authors.affiliation: Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic; Institute of Experimental Biology, Faculty of Science, Masaryk University, Kotlářská 267/2, 611 37 Brno, Czech Republic.
authors.forename: Katarina
authors.initials: K
authors.lastname: Chlebova
authors.affiliation: Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
authors.forename: Lenka
authors.initials: L
authors.lastname: Leva
authors.affiliation: Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic; Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Palackého 1/3, 612 42 Brno, Czech Republic.
authors.forename: Alena
authors.initials: A
authors.lastname: Osvaldova
authors.affiliation: Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic; Institute of Experimental Biology, Faculty of Science, Masaryk University, Kotlářská 267/2, 611 37 Brno, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Gebauer
authors.affiliation: Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Faldyna
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D060085:Coinfection / Q000276:immunology; D005243:Feces / Q000382:microbiology; D012481:Salmonella Infections, Animal / Q000276:immunology*; D019779:Salmonella enterica / Q000276:immunology* / Q000302:isolation & purification; D012486:Salmonella typhimurium / Q000276:immunology* / Q000302:isolation & purification; D013552:Swine; D013553:Swine Diseases / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial
keywords: Derby; Immune response; Pig; Salmonella; Typhimurium