title: Modafinil augments oscillatory power in middle frequencies during rule selection.
abstract: Control-related cognitive processes are associated with cortical oscillations and modulated by catecholamine neurotransmitters. It remains unclear how catecholamine systems modulate control-related oscillations. We tested modafinil effects on rule-related 4-30 Hz oscillations, with double-blind, placebo-controlled (within-subjects) testing of 22 healthy adults, using EEG during cognitive control task performance. EEG data underwent time-frequency decomposition with Morlet wavelets to determine power of 4-30 Hz oscillations. Modafinil enhanced oscillatory power associated with high-control rule selection in theta, alpha, and beta ranges, with a frontotemporal topography and minimal effects during rule maintenance. Augmentation of catecholamine signaling enhances middle-frequency cortical oscillatory power associated with rule selection, which may subserve diverse subcomponent processes in proactive cognitive control.
authors.affiliation: Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, California, USA; San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Minzenberg
authors.forename: Glenn C
authors.initials: GC
authors.lastname: Gomes
authors.forename: Jong H
authors.initials: JH
authors.lastname: Yoon
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Watrous
authors.forename: Joy
authors.initials: J
authors.lastname: Geng
authors.forename: Alana J
authors.initials: AJ
authors.lastname: Firl
authors.forename: Cameron S
authors.initials: CS
authors.lastname: Carter
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077408:Modafinil; D058067:Wavelet Analysis; D055815:Young Adult
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D000077408:Modafinil
keywords: Cognitive control; Modafinil; Oscillations; Prefrontal cortex; Rule selection; Theta