title: Synthesis of naphthalene derivatives from ortho-alkynylacetophenone derivatives via tandem in situ incorporation of acetal and intramolecular heteroalkyne metathesis/annulation.
abstract: An interesting domino reaction for the synthesis of substituted naphthyl ketones has been developed using readily accessible starting materials. This domino reaction proceeds via in situ incorporation of an acetal followed by intramolecular heteroalkyne metathesis/annulation in an ortho-alkynylacetophenone derivative. A deuterium incorporation experiment has been carried out to understand the mechanism.
authors.affiliation: School of Chemistry, University of Hyderabad , Gachibowli, Hyderabad, India 500046.
authors.forename: Seetharaman
authors.initials: S
authors.lastname: Manojveer
authors.forename: Rengarajan
authors.initials: R
authors.lastname: Balamurugan
mesh_terms: D000080:Acetals / Q000737:chemistry; D000098:Acetophenones / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003903:Deuterium / Q000737:chemistry; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000080:Acetals; D000098:Acetophenones; D000480:Alkynes; D009281:Naphthalenes; D003903:Deuterium