title: Tellurium-containing polymer micelles: competitive-ligand-regulated coordination responsive systems.
abstract: Nanomaterials capable of achieving tunable cargo release kinetics are of significance in a fundamental sense and various biological or medical applications. We report a competitive coordination system based on a novel tellurium-containing polymer and its ligand-regulated release manners. Tellurium was introduced to water-soluble polymers for the first time as drug delivery vehicles. The coordination chemistry between platinum and tellurium was designed to enable the load of platinum-based drugs. Through the competitive coordination of biomolecules, the drugs could be released in a controlled manner. Furthermore, the release kinetics could be modulated by the competitive ligands involved due to their different coordination ability. This tellurium-containing polymer may enrich the family of delivery systems and provide a new platform for future biomedical nanotechnologies.
authors.affiliation: Key Lab of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University , Beijing 100084, China .
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Gu
authors.forename: Myriam
authors.initials: M
authors.lastname: Meineck
authors.forename: Tianyu
authors.initials: T
authors.lastname: Li
authors.forename: Huaping
authors.initials: H
authors.lastname: Xu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems; D056945:Hep G2 Cells; D006801:Humans; D008024:Ligands; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry*; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology; D013691:Tellurium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D008024:Ligands; D008823:Micelles; D009944:Organoplatinum Compounds; D011108:Polymers; D011725:Pyridines; C431073:oxiplatin; D013691:Tellurium; D002945:Cisplatin