title: TNFAIP8 overexpression is associated with lymph node metastasis and poor prognosis in intestinal-type gastric adenocarcinoma.
abstract: OBJECTIVE
  Tumour necrosis factor alpha-induced protein 8 (TNFAIP8) is implicated in the progression of several human malignancies, but its role in gastric adenocarcinoma is unknown. TNFAIP8 expression and its correlation with clinical significance in gastric adenocarcinoma are evaluated in this study.
  
  
  RESULTS
  The expression of TNFAIP8 was determined in primary gastric adenocarcinoma tissues using immunohistochemistry (IHC) and Western blotting analysis. TNFAIP8 expression was higher in gastric adenocarcinoma tissues. Elevated expression of TNFAIP8 in gastric adenocarcinoma was associated significantly with depth of invasion (P = 0.024), lymph node metastasis (P = 0.038) and Lauren classification (P = 0.048). Patients with tumours showing high TNFAIP8 expression had a significantly poorer overall survival (OS) and disease-free survival (DFS) than those with low TNFAIP8 expression in intestinal-type gastric adenocarcinoma (IGA) (P = 0.001 for both). In the multivariate Cox analysis, TNFAIP8 expression was an independent prognostic marker for OS and DFS in IGA with P-values of 0.006 and 0.007, respectively.
  
  
  CONCLUSIONS
  Our data suggest that TNFAIP8 overexpression may contribute to lymph node metastasis and poor prognosis in IGA.
authors.affiliation: Department of Gastrointestinal Medical Oncology, The Affiliated Tumour Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Wang
authors.forename: Tianbo
authors.initials: T
authors.lastname: Liu
authors.forename: Guodong
authors.initials: G
authors.lastname: Yao
authors.forename: Changjie
authors.initials: C
authors.lastname: Lou
authors.forename: Yanqiao
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality* / Q000473:pathology*; D055815:Young Adult
chemical_list: D051017:Apoptosis Regulatory Proteins; C404190:TNFAIP8 protein, human
keywords: TNFAIP8; gastric adenocarcinoma; immunohistochemistry; prognosis