title: Effectiveness of Hyalobarrier and Seprafilm to prevent polypropylene mesh shrinkage: a macroscopic and histological experimental study.
abstract: OBJECTIVE
  Polypropylene (PP) mesh shrinkage represents a serious complication, as a significant cause of pain and recurrence of pelvic organ prolapse or ventral hernias, frequently requiring several surgical interventions. The retraction seems to be caused by the host, in response to the implantation, through the occurrence of periprosthetic adhesions and fibrosis. We hypothesized that avoiding the postoperative adhesions can prevent PP mesh shrinkage.
  
  
  METHODS
  Sixty rats were randomly assigned to three groups. A standardized hernia defect was induced on the abdominal wall, which was repaired using an extraperitoneal PP mesh alone (group 1), with application of a hyaluronate carboxymethylcellulose-based bioresorbable membrane (Seprafilm, group 2), or an auto-cross-linked polysaccharide hyaluronan-based solution (Hyalobarrier gel, group 3). Eight weeks after the procedure, a repeat laparotomy was performed. After scoring the adhesion and measuring the mesh surface, a microscopic study of the prosthesis-host tissue interfaces was performed.
  
  
  RESULTS
  Group 1 displayed a median shrinkage of 29% of the mesh. The Seprafilm group (p = 0.0238) and Hyalobarrier gel group (p = 0.0072) displayed a significantly smaller reduction of 19.12 and 17 %, respectively. Control group 1 displayed a significantly greater adhesion score (30.40) than the Seprafilm (11.67, p = 0.0028) and Hyalobarrier gel groups (11.19, p = 0.0013). The fibrosis was reduced in the Hyalobarrier gel group only.
  
  
  CONCLUSIONS
  This experimental study revealed that Hyalobarrier gel and Seprafilm can prevent PP mesh shrinkage and postoperative adhesions. They might be integrated in a mesh size-saving strategy, which should preserve the quality and durability of the surgical repair and limit the postoperative pain.
authors.affiliation: Department of Obstetrics and Gynecology, General Hospital of Thiers, Route du Fau, 63300, Thiers, France, enohuz@yahoo.fr.
authors.forename: Erdogan
authors.initials: E
authors.lastname: Nohuz
authors.forename: Maher
authors.initials: M
authors.lastname: Alaboud
authors.forename: Claude
authors.initials: C
authors.lastname: Darcha
authors.forename: Abdelkrim
authors.initials: A
authors.lastname: Alloui
authors.forename: Bruno
authors.initials: B
authors.lastname: Aublet-Cuvelier
authors.forename: Bernard
authors.initials: B
authors.lastname: Jacquetin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D005260:Female; D005355:Fibrosis; D005782:Gels; D046449:Hernia, Abdominal / Q000601:surgery; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D011126:Polypropylenes; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D011446:Prospective Studies; D011475:Prosthesis Failure / Q000209:etiology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013526:Surgical Mesh; D000267:Tissue Adhesions / Q000150:complications / Q000473:pathology / Q000517:prevention & control*
chemical_list: D001672:Biocompatible Materials; D005782:Gels; D011126:Polypropylenes; C118198:Seprafilm; D006820:Hyaluronic Acid