title: Reprogramming can be a transforming experience.
abstract: Since the inception of nuclear reprogramming, the parallels between this process and tumorigenesis have become increasingly apparent. Recent studies by Abad et al. and Ohnishi et al. have now formalized this connection by demonstrating that the same transcription factors used for reprogramming to pluripotency drive tumor initiation in vivo.
authors.affiliation: Australian Regenerative Medicine Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne 3800, VIC, Australia.
authors.forename: Robin M
authors.initials: RM
authors.lastname: Hobbs
authors.affiliation: Australian Regenerative Medicine Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne 3800, VIC, Australia. Electronic address: jose.polo@monash.edu.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Polo
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D044127:Epigenesis, Genetic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D013724:Teratoma / Q000378:metabolism*; D039901:Totipotent Stem Cells / Q000166:cytology*