title: A MEMS-based passive hydrocephalus shunt for body position controlled intracranial pressure regulation.
abstract: This paper reports a novel micro electro mechanical system (MEMS) valve with posture controlled flow characteristics for improved treatment of hydrocephalus, a disease that is characterized by elevated pressure in the cerebrospinal fluid (CSF) that surrounds the brain and spinal cord. In contrast to conventional differential pressure CSF valves, the CSF valve presented here features a third port which utilizes hydrostatic pressure from a pressure compensating catheter to adapt CSF drainage to optimized levels irrespective of body position. Prototypes have been fabricated using standard MEMS manufacturing processes and the experimental evaluation successfully showed that the flow rate was adjustable with a varying hydrostatic pressure on the third port. Measured data showed that flow rate was at near ideal values at laying body position and that the flow rate can be adjusted to optimal values at standing body position by selecting an appropriate length of the pressure compensating catheter. This is the first pressure balanced CSF valve intended for body position controlled CSF pressure regulation.
authors.affiliation: Micro and Nanosystems, KTH Royal Institute of Technology, Osquldas Väg 10, 10044, Stockholm, Sweden, stajoh@kth.se.
authors.forename: Staffan B
authors.initials: SB
authors.lastname: Johansson
authors.forename: Anders
authors.initials: A
authors.lastname: Eklund
authors.forename: Jan
authors.initials: J
authors.lastname: Malm
authors.forename: Göran
authors.initials: G
authors.lastname: Stemme
authors.forename: Niclas
authors.initials: N
authors.lastname: Roxhed
mesh_terms: D001921:Brain / Q000378:metabolism; D002557:Cerebrospinal Fluid Shunts / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid* / Q000601:surgery*; D007427:Intracranial Pressure / Q000502:physiology*; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation / Q000379:methods*; D011187:Posture / Q000502:physiology*