title: Usefulness of Strongyloides stercoralis serology in the management of patients with eosinophilia.
abstract: Strongyloides stercoralis infection is being increasingly diagnosed out of endemic areas. The aim of this study is to evaluate the usefulness of S. stercoralis serology for the management of probable strongyloidiasis in patients presenting with eosinophilia. Overall, 147 patients were included, 89 (60.5%) patients had a positive S. stercoralis serology. Strongyloides stercoralis larvae were detected only in 15 (10.2%) patients. Twenty-eight patients had human immunodeficiency virus infection. Eighty patients received ivermectin 200 mcg/Kg/day for 2 days, and follow-up 6 months after treatment could be performed in 32 patients: 26 (81.3%) patients reached the response to treatment criteria (negative serology 6 months after treatment or when by enzyme-linked immunosorbent assay the optical density ratio of post-treatment to pre-treatment decreased to 0.6), and 11 (34.4%) patients fulfilled the cure criteria (negative serology 6 months after treatment). Strongyloides stercoralis serology is a useful diagnostic tool both in the diagnosis of probable strongyloidiasis and follow-up after treatment.
authors.affiliation: Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Microbiology, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Salvador
authors.forename: Elena
authors.initials: E
authors.lastname: Sulleiro
authors.forename: Adrián
authors.initials: A
authors.lastname: Sánchez-Montalvá
authors.forename: José María
authors.initials: JM
authors.lastname: Saugar
authors.forename: Esperanza
authors.initials: E
authors.lastname: Rodríguez
authors.forename: Albert
authors.initials: A
authors.lastname: Pahissa
authors.forename: Israel
authors.initials: I
authors.lastname: Molina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D004802:Eosinophilia / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology*; D005243:Feces / Q000469:parasitology; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000469:parasitology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007559:Ivermectin / Q000627:therapeutic use; D007814:Larva; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017171:Strongyloides stercoralis / Q000187:drug effects* / Q000302:isolation & purification; D013322:Strongyloidiasis / Q000175:diagnosis* / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D007559:Ivermectin