title: Imaging intracellular anticancer drug delivery by self-assembly micelles with aggregation-induced emission (AIE micelles).
abstract: Nanoformulations show many therapeutic advantages over conventional formulations. We seek to develop traceable nanoformulations in order to closely monitor delivery. Herein, we developed a new drug delivery system (DDS) using tetraphenylethene (TPE) to fabricate a self-assembly micelle with aggregation-induced emission (AIE micelle). AIE makes the nanocarriers visible for high-quality imaging, and the switching on and off of the AIE is intrinsically controlled by the assembly and disassembly of the micelles. This DDS was tested for doxorubicin (DOX) delivery and intracellular imaging. For the DOX-loaded micelles (TPED), the DOX content reached as much as 15.3% by weight, and the anticancer efficiency was higher than for free DOX. Meanwhile, high-quality imaging was obtained to trace the intracellular delivery of the TPED.
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology , No. 11 Beiyitiao, Zhongguancun, Beijing 100190, China.
authors.forename: Chunqiu
authors.initials: C
authors.lastname: Zhang
authors.forename: Shubin
authors.initials: S
authors.lastname: Jin
authors.forename: Shengliang
authors.initials: S
authors.lastname: Li
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Xue
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Yuran
authors.initials: Y
authors.lastname: Huang
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Jiang
authors.forename: Wei-Qiang
authors.initials: WQ
authors.lastname: Chen
authors.forename: Guozhang
authors.initials: G
authors.lastname: Zou
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008823:Micelles
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D004317:Doxorubicin