title: Mapping the amino acid properties of constituent nucleoporins onto the yeast nuclear pore complex.
abstract: Visualization of molecular structures aids in the understanding of structural and functional roles of biological macromolecules. Macromolecular transport between the cell nucleus and cytoplasm is facilitated by the nuclear pore complex (NPC). The ring structure of the NPC is large and contains several distinct proteins (nucleoporins) which function as a selective gate for the passage of certain molecules into and out of the nucleus. In this note we demonstrate the utility of a python code that allows direct mapping of the physiochemical properties of the constituent nucleoporins on the scaffold of the yeast NPC׳s cytoplasmic view. We expect this tool to be useful for researchers to visualize the NPC based on their physiochemical properties and how it alters when specific mutations are introduced in one or more of the nucleoporins. The code developed using Python is available freely from the authors.
authors.affiliation: Davis Senior High School, 315 West 14th Street, Davis, CA 95616 ; Contributed equally.
authors.forename: Ashok
authors.initials: A
authors.lastname: Kunda
authors.affiliation: Davis Senior High School, 315 West 14th Street, Davis, CA 95616 ; Contributed equally.
authors.forename: Narayanan H
authors.initials: NH
authors.lastname: Krishnan
authors.affiliation: Department of Chemistry, California State University, Fresno CA 93740 and ; Department of Medical Pathology and Laboratory Medicine, University of California Davis School of Medicine,Davis, CA 95616.
authors.forename: Vv
authors.initials: V
authors.lastname: Krishnan
keywords: AA Index; IDP (intrinsically disordered protein); NPC (nuclear pore complex)