title: Optic neuritis revealing Kikuchi-Fujimoto disease.
abstract: Kikuchi-Fujimoto disease is a rare systemic disease with uncommon neurological involvement. We report the case of a 30-year-old Asian woman who presented a rapidly progressive loss of vision. Magnetic resonance imaging (MRI) of the optic nerve revealed an inflammation of the left optic nerve with chiasmatic involvement, without any encephalic or medullar lesion. Thoracic computed tomography scan showed bilateral axillary lymphadenopathy. Analysis of a biopsy of the axillary lymph node showed typical histological findings of Kikuchi-Fujimoto disease. There was no clinical or biological sign of associated systemic lupus erythematosus. The patient spontaneously recovered normal visual acuity in 4 weeks, with resolution of MRI abnormalities. No optic neuritis relapse or neurological event occurred in a 3-year follow-up. To our knowledge this is the first case of optic neuritis associated with Kikuchi-Fujimoto disease.
authors.affiliation: Department of Neurology, Fondation Ophtalmologique Rothschild, Paris, France bouquetfloriane@gmail.com.
authors.forename: F
authors.initials: F
authors.lastname: Bouquet
authors.affiliation: Department of Neurology, Fondation Ophtalmologique Rothschild, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Maillart
authors.affiliation: Department of Ophtalmology, Fondation Ophtalmologique Rothschild, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Vignal
authors.affiliation: Department of Histopathology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Battistella
authors.affiliation: Department of Histopathology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Meignin
authors.affiliation: Department of Clinical Immunology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Galicier
authors.affiliation: Department of Neurology, Fondation Ophtalmologique Rothschild, Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Gout
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D009902:Optic Neuritis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000209:etiology / Q000503:physiopathology; D014785:Vision, Ocular
keywords: Optic neuritis; histiocytic necrotizing lymphadenitis; lupus erythematosus; magnetic resonance imaging