title: 5,10-seco-neo-clerodanes and neo-clerodanes from Salvia microphylla.
abstract: Two new 5,10-seco-neo-clerodanes, salvimicrophyllins A and B (1 and 2), and two new neo-clerodanes, salvimicrophyllins C and D (3 and 4), were isolated from the leaves and flowers of Salvia microphylla. The structures of these compounds were elucidated mainly by analysis of their NMR spectroscopic and mass spectrometric data. The relative configurations of the salvimicrophyllins were determined by analysis of NOESY spectra and ECD curves, and the relative configuration of compound 2 was confirmed by single-crystal X-ray diffraction crystallography.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México City, México.
authors.forename: Elihú
authors.initials: E
authors.lastname: Bautista
authors.forename: Rubén A
authors.initials: RA
authors.lastname: Toscano
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ortega
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D035264:Flowers / Q000737:chemistry; D006801:Humans; D020014:K562 Cells; D008800:Mexico; D051379:Mice; D008954:Models, Biological; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; D013755:Tetradecanoylphorbol Acetate