title: Mitochondria: prospective targets for neuroprotection in Parkinson's disease.
abstract: Parkinson's disease is the second most common neurodegenerative disorder characterized by persistent loss of dopaminergic neurons in the SN and clinically associated with cognitive, behavioral and motor deficits. There is an enormous amount of data that provides convincing evidence about the prime involvement of mitochondria in the onset and progression of neurodegeneration. Several studies have also emphasized that accumulation of toxic protein and their aggregates in mitochondria lead to energy deficits, excessive ROS generation, mutations in mitochondrial genome and proteins regulating mitochondrial homeostasis, and impaired mitochondrial dynamics in animal models of PD and patients. Here we discuss about the bioenergetic agents, which have been tested for reducing the mitochondrial dysfunction and associated disease pathology in cellular and animal models of PD and PD patients with encouraging outcomes. We also provide a succinct overview of current therapeutic implications of PGC-1α, SIRT, AMPK, and Nrf2-ARE as salutary targets to overcome the deleterious effects posed by mitochondrial dysfunction in the onset and progression of PD.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Yadav
authors.forename: Swati
authors.initials: S
authors.lastname: Agarwal
authors.forename: Shashi Kant
authors.initials: SK
authors.lastname: Tiwari
authors.affiliation: Developmental Toxicology Division, Systems Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 80 MG Marg, Lucknow 226001, India. rajnish@iitr.res.in.
authors.forename: Rajnish K
authors.initials: RK
authors.lastname: Chaturvedi
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D010300:Parkinson Disease / Q000188:drug therapy* / Q000378:metabolism*; D014315:Triterpenes / Q000008:administration & dosage
chemical_list: D000978:Antiparkinson Agents; D018696:Neuroprotective Agents; D014315:Triterpenes