title: Konjac glucomannan, a promising polysaccharide for OCDDS.
abstract: Oral colon targeting drug delivery system (OCDDS) is a highly effective formulation for drugs absorbed by colon, or to treat colonic diseases specifically. To obtain colon targeting, many pharmaceutical approaches have been studied, among which, taking advantage of specific degradation of excipients by colon enzymes is one of the most promising strategies. With properties of specific colon β-mannanase degradation, biocompatibility, gel-forming, low toxicity and high stability, konjac glucomannan (KGM) becomes a promising natural excipient for oral OCDDS. This paper summaries structure and properties of KGM, reviews achievements and prospects on KGM and modified konjac glucomannan about their application as pharmaceutic excipient for the OCDDS recently.
authors.affiliation: School of Chemistry and Chemical Engineering, ChongQing University, ChongQing 400030, People's Republic of China.
authors.forename: Cui
authors.initials: C
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, ChongQing University, ChongQing 400030, People's Republic of China. Electronic address: chencqu@cqu.edu.cn.
authors.forename: Ji-da
authors.initials: JD
authors.lastname: Chen
authors.affiliation: School of Chemistry and Chemical Engineering, ChongQing University, ChongQing 400030, People's Republic of China.
authors.forename: Feng-Qing
authors.initials: FQ
authors.lastname: Yang
mesh_terms: D000284:Administration, Oral; D031056:Amorphophallus / Q000737:chemistry*; D000818:Animals; D003106:Colon / Q000187:drug effects; D016503:Drug Delivery Systems / Q000379:methods*; D008351:Mannans / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D008351:Mannans; C022901:(1-6)-alpha-glucomannan
keywords: Colon targeting; Excipient; Konjac glucomannan