title: Urinary angiotensinogen, related factors and clinical implications in normotensive autosomal dominant polycystic kidney disease patients.
abstract: BACKGROUND
  Although several lines of evidence suggest that renin angiotensin system (RAS) proteins are synthesized by cyst epithelium and dilated tubules, role of intrarenal RAS in the progression of otozomal dominant polycystic kidney disease (ADPKD) is not well known. We aimed to study the levels and clinical correlations of urinary angiotensinogen (UAGT) in normotensive ADPKD patients compared with age- and sex-matched healthy subjects.
  
  
  METHODS
  The study included 20 normotensive ADPKD patients (F/M: 11/9) and 20 age and sex matched healthy controls (F/M: 9/11). Diagnosis of ADPKD was made based on Ravine criteria. Twenty-four hours ambulatory blood pressure monitoring (ABPM) was performed. Serum concentrations of creatinine, Na, K, uric acid, and urinary concentrations of Na, K, uric acid, creatinine, protein and albumin were measured. UAGT were measured via commercially available ELISA kit.
  
  
  RESULTS
  ADPKD patients had higher urinary albumin:creatinine ratio (UAIb/UCrea) than healthy controls (p < 0.01). UAGT/UCrea levels significantly positively correlated with urinary protein: creatinine ratio (UPro/UCrea) (r = 0.785, p = 0.01), and UAIb/UCrea (r = 0.681, p = 0.01) in normotensive ADPKD patients.
  
  
  CONCLUSIONS
  This pilot study demonstrates that UAGT levels tend to be elevated and are correlated with proteinuria and albuminuria in normotensive ADPKD patients during relatively early stages of the disease.
authors.affiliation: Department of Nephrology, School of Medicine, Ankara University , Ankara , Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Kurultak
authors.forename: Sule
authors.initials: S
authors.lastname: Sengul
authors.forename: Senem
authors.initials: S
authors.lastname: Kocak
authors.forename: Siyar
authors.initials: S
authors.lastname: Erdogmus
authors.forename: Reyhan
authors.initials: R
authors.lastname: Calayoglu
authors.forename: Pinar
authors.initials: P
authors.lastname: Mescigil
authors.forename: Kenan
authors.initials: K
authors.lastname: Keven
authors.forename: Sehsuvar
authors.initials: S
authors.lastname: Erturk
authors.forename: Bulent
authors.initials: B
authors.lastname: Erbay
authors.forename: Neval
authors.initials: N
authors.lastname: Duman
mesh_terms: D000328:Adult; D000808:Angiotensinogen / Q000652:urine*; D001794:Blood Pressure; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D010865:Pilot Projects; D016891:Polycystic Kidney, Autosomal Dominant / Q000652:urine*; D055815:Young Adult
chemical_list: D000808:Angiotensinogen
keywords: Albuminuria; autosomal dominant polycystic kidney disease; kidney damage; proteinuria; urinary angiotensinogen