title: Case of uterine papillary serous carcinoma following tamoxifen treatment that could not be diagnosed during screening.
abstract: This case involved a 69-year-old woman who had been taking tamoxifen for 5 years after breast cancer surgery. She was referred to our clinic for endometrial cancer screening when tamoxifen was first prescribed. Subsequently, transvaginal ultrasonography and endometrial cytology were performed every 6 months. Despite these regular examinations, stage IVb papillary serous carcinoma was detected 8 months after the end of tamoxifen administration. Total abdominal hysterectomy was performed, but only a small polyp was seen upon macroscopic examination of the uterus. However, papillary serous carcinoma was found microscopically in almost all lymphovascular spaces in the uterus from the endometrium to the serosa. On the surface of the polyp, only endometrial intraepithelial carcinoma with positive immunostaining for p53 was detected. Chemotherapy, including a platinum compound, was administrated, but unfortunately it was ineffective and the patient died of her disease 14 months after the operation.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka Police Hospital, Osaka, Japan.
authors.forename: Takahide
authors.initials: T
authors.lastname: Maenaka
authors.forename: Tomomi
authors.initials: T
authors.lastname: Egawa-Takata
authors.forename: Koji
authors.initials: K
authors.lastname: Hisamoto
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kunishige
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Nishio
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsujimoto
mesh_terms: D000368:Aged; D018283:Cystadenocarcinoma, Papillary / Q000175:diagnosis* / Q000209:etiology; D018284:Cystadenocarcinoma, Serous / Q000175:diagnosis* / Q000209:etiology; D004965:Estrogen Antagonists / Q000009:adverse effects*; D005260:Female; D006801:Humans; D013629:Tamoxifen / Q000009:adverse effects*; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000209:etiology
chemical_list: D004965:Estrogen Antagonists; D013629:Tamoxifen
keywords: cytology; endometrial; serous carcinoma; tamoxifen; uterine neoplasms