title: Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244).
abstract: A marine-derived Streptomyces sp. (CMB-M0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C3 Marfey's analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC50 10-50 nM) and drug-sensitive (3D7; IC50 7 nM) and multidrug-resistant (Dd2; IC50 9 nM) clones of the malaria parasite Plasmodium falciparum.
authors.affiliation: Institute for Molecular Bioscience, The University of Queensland , St. Lucia, QLD 4072, Australia.
authors.forename: Ritesh
authors.initials: R
authors.lastname: Raju
authors.forename: Zeinab G
authors.initials: ZG
authors.lastname: Khalil
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Piggott
authors.forename: Antje
authors.initials: A
authors.lastname: Blumenthal
authors.forename: Donald L
authors.initials: DL
authors.lastname: Gardiner
authors.forename: Tina S
authors.initials: TS
authors.lastname: Skinner-Adams
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Capon
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000962:Antimalarials / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D001315:Australia; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D047630:Depsipeptides; D061065:Polyketides; C000588618:mollemycin A