title: Synthesis of some novel 1,2,4-triazol-3-one derivatives bearing the salicyl moiety and their anticonvulsant activities.
abstract: A series of new 1,2,4-triazole-3-one derivatives bearing the salicyl moiety were synthesized by using microwave irradiation, and their chemical structures were identified by IR, (1) H NMR, (13) C NMR, elemental analysis, and LC-MS. The anticonvulsant activities of the compounds 4a-c, 4e, and 5a-e were evaluated by the Anticonvulsant Screening Program of the National Institute of Health, USA. The compounds had moderate anticonvulsant activities in the maximum electroshock-induced seizure and minimal clonic seizure models in mice, without any neurotoxic effects.
authors.affiliation: Faculty of Health Sciences, Department of Nutrition and Dietetics, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Bahittin
authors.initials: B
authors.lastname: Kahveci
authors.forename: Emre
authors.initials: E
authors.lastname: Menteşe
authors.forename: Emre
authors.initials: E
authors.lastname: Akkaya
authors.forename: Fatih
authors.initials: F
authors.lastname: Yılmaz
authors.forename: Inci S
authors.initials: IS
authors.lastname: Doğan
authors.forename: Arzu
authors.initials: A
authors.lastname: Ozel
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D004195:Disease Models, Animal; D015195:Drug Design; D004597:Electroshock; D051379:Mice; D015394:Molecular Structure; D012459:Salicylates / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*; D013329:Structure-Activity Relationship; D013997:Time Factors; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000927:Anticonvulsants; D012459:Salicylates; D014230:Triazoles
keywords: Anticonvulsant activity; Microwave irradiation; Salicyl aldehyde; Triazol-3-one