title: [Relapsed primary intraocular lymphoma treated with intravitreal methotrexate and high-dose chemotherapy followed by autologous stem cell rescue].
abstract: A 58-year-old woman with primary intraocular lymphoma (PIOL) of her right eye was treated with combination chemotherapy (methotrexate, procarbazine and vincristine) followed by irradiation to her brain and right eye. However, the disease recurred in the right eye four months later. She was treated with intravitreal injection of methotrexate and high-dose chemotherapy in combination with autologous stem cell transplantation after salvage therapy consisting of cytarabine, etoposide and rituximab. With this treatment strategy, she has been in remission for more than one year with no deterioration of either leukoencephalopathy or cognitive function. Intravitreal injection of methotrexate and high-dose chemotherapy may now be regarded as one of the treatment choices for relapsed PIOL.
authors.affiliation: Depertment of Medicine and Clinical Science, Gunma University Graduate School of Medicine.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kamio
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yokohama
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Hayashi
authors.forename: Kotaro
authors.initials: K
authors.lastname: Toyama
authors.forename: Hiroko
authors.initials: H
authors.lastname: Koya
authors.forename: Takumi
authors.initials: T
authors.lastname: Hoshino
authors.forename: Takayuki
authors.initials: T
authors.lastname: Saitoh
authors.forename: Naoto
authors.initials: N
authors.lastname: Hanyuda
authors.forename: Ryou
authors.initials: R
authors.lastname: Mukai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Handa
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Murakami
authors.forename: Norifumi
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nojima
mesh_terms: D005134:Eye Neoplasms / Q000628:therapy*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008223:Lymphoma / Q000628:therapy*; D008727:Methotrexate / Q000008:administration & dosage*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D008727:Methotrexate