title: [Diagnosis and management of hereditary colorectal cancer according to the JSCCR Guidelines 2012 for the Clinical Practice of Hereditary Colorectal Cancer].
abstract: We summarized the key points of the diagnosis and management of familial adenomatous polyposis (FAP) and Lynch syndrome (LS) according to the JSCCR Guidelines 2012 for the Clinical Practice of Hereditary Colorectal Cancer. The diagnosis of FAP is made clinically and/or genetically. A total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the standard treatment for preventing the development of colorectal cancer, while a total colectomy with ileo-rectal anastomosis (IRA) is an alternative option in select patients. Surveillance for the remnant (colo) rectal mucosa and extra-colonic manifestations, such as the desmoid tumors or duodenal polyposis, is important. Meanwhile, genetic testing is essential for the diagnosis of LS. The genetic testing for mismatch repair gene (s) (MLH1, MSH2, MSH6, and PMS2) is performed using a microsatellite instability test or immunohistochemistry for the 4 kinds of mismatch repair proteins in colorectal cancer tissue from patients who meet the Amsterdam criteria or the revised Bethesda guidelines. Surveillance for metachronous colorectal cancer and extracolonic neoplasms is mandatory in LS patients undergoing surgery for initially diagnosed colorectal cancer.
authors.affiliation: Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ishida
authors.affiliation: Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.
authors.forename: Takeo
authors.initials: T
authors.lastname: Iwama
authors.affiliation: Division of Lower GI Surgery, Department of Surgery, Hyogo College of Medicine.
authors.forename: Naohiro
authors.initials: N
authors.lastname: Tomita
authors.affiliation: Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious diseases, Center Komagome Hospital.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Koizumi
authors.affiliation: Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center.
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Akagi
authors.affiliation: Department of Surgical Oncology, Tokyo Medical and Dental University Graduate School.
authors.forename: Megumi
authors.initials: M
authors.lastname: Ishiguro
authors.affiliation: Department of Surgical Oncology, University of Tokyo.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Department of Surgical Oncology, Tokyo Medical and Dental University Graduate School.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugihara
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000175:diagnosis* / Q000601:surgery; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D017410:Practice Guidelines as Topic