title: Effect of underlying infertility factors on second trimester serum screening results.
abstract: OBJECTIVE
  To determine whether assisted reproductive technologies (ART) alone or an underlying cause of infertility has any effect on second trimester serum screening results.
  
  
  METHODS
  Second trimester serum screening results of ART pregnancies of women with polycystic ovary syndrome (IVF-P group) were compared with those of women who underwent ART due to malefactor infertility (IVF-M group) and of women who conceived spontaneously.
  
  
  RESULTS
  Comparison of the groups for a-fetoprotein, beta-hCG, and beta-hCG multiples of the median (MoM) revealed a significant difference between the IVF-M and control groups. Comparison of groups for unconjugated estriol (uE3) and uE3 MoM levels revealed a statistically significant difference between the IVF-P versus the control groups.
  
  
  CONCLUSIONS
  It seems advisable to use a population of ART pregnancies, preferably divided by type of treatment and the etiology of the infertility, when establishing median curves for second trimester serum screening markers.
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Ozal University, Faculty of Medicine, Ankara, Turkey. nerminkosus@gmail.com
authors.forename: Nermin
authors.initials: N
authors.lastname: Köşüş
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Ozal University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Köşüş
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Ozal University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Müzeyyen
authors.initials: M
authors.lastname: Duran
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Ozal University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Nilgiin O
authors.initials: NO
authors.lastname: Turhan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D002869:Chromosome Aberrations; D004314:Down Syndrome / Q000097:blood; D004964:Estriol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000209:etiology*; D007248:Infertility, Male / Q000097:blood*; D008297:Male; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis; D012016:Reference Values; D012189:Retrospective Studies; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins; D004964:Estriol