title: Low-dose rituximab in the treatment of acquired haemophilia.
abstract: OBJECTIVE
  Acquired haemophilia is a rare hemorrhagic disease caused by inhibitory autoantibodies against coagulation factor VIII. Rituximab has become a popular choice for immunosuppressive therapy in acquired haemophilia, almost with the same schedule of 375 mg/m(2) per week for 4-6 doses. While the effect of low-dose rituximab has seldom been reported.
  
  
  METHODS
  We report a patient, aged 88 years, who developed acquired haemophilia with severe hemorrhage and elevation of carbohydrate antigen 125 (CA125), but in the absence of a detectable cause.
  
  
  METHODS
  We prescribed a low-dose rituximab alone (100 mg per week for a total of four infusions) for the patient, different from the conventional usage, but received a similar effect. In addition, the patient was diagnosed with immune thrombocytopenia 22 months after rituximab, while FVIII activity and activated partial thromboplastin time remained within the normal range. After four infusions of low-dose rituximab, the platelet count recovered.
  
  
  CONCLUSIONS
  At a follow-up of 34 months, the patient remains in remission without further treatment, suggesting low-dose rituximab seems to be a safe and effective regimen for the elderly patients with acquired haemophilia.
authors.forename: Qingmin
authors.initials: Q
authors.lastname: Yao
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Zhu
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Ting
authors.initials: T
authors.lastname: Yuan
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
mesh_terms: D000369:Aged, 80 and over; D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage*; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D000069283:Rituximab
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007166:Immunosuppressive Agents; D000069283:Rituximab
keywords: Acquired haemophilia; Factor VIII inhibitor; Rituximab