title: Recurrent laryngeal inflammatory myofibroblastic tumor with positive anaplastic lymphoma kinase mimicking recurrent respiratory papillomatosis: a case report.
abstract: Inflammatory myofibroblastic tumor (IMT) of the larynx is an unusual lesion, particularly in the pediatric age group. Laryngeal IMTs in children follow a benign clinical course with reports of only rare recurrences and no metastases. Although anaplastic lymphoma kinase (ALK) has been associated with IMTs, there is only one pediatric laryngeal IMT reported to be ALK-positive with immunohistochemical staining. Here, we present a case of a 10-year-old boy with a laryngeal IMT that recurred four times and was misdiagnosed as recurrent respiratory papillomatosis after the initial three operations. ALK positivity was demonstrated by both immunohistochemical staining and fluorescence in situ hybridization. To the best of our knowledge, this case report is the first to describe a laryngeal IMT that recurred multiple times and was confirmed to be ALK-positive at the molecular level.
authors.forename: Chun-yan
authors.initials: CY
authors.lastname: He
authors.forename: Ge-hong
authors.initials: GH
authors.lastname: Dong
authors.affiliation: Department of Pathology, Beijing Tongren Hospital, Capital Medical University, No,1 Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China. liuhg1125@163.com.
authors.forename: Hong-gang
authors.initials: HG
authors.lastname: Liu
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D011379:Prognosis; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases