title: Oxidative stress early in infancy and neurodevelopmental outcome in very low-birthweight infants.
abstract: BACKGROUND
  Reactive oxygen species may be involved in serious diseases in premature infants. The objective of this study was to assess the relationship between neurodevelopmental outcome and oxidative stress marker level in the urine of very low-birthweight (VLBW) infants.
  
  
  METHODS
  Spot urine samples were collected from 35 VLBW infants. Urinary excretion of 8-hydroxy-2″-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and 8-iso-prostaglandin F2α (8-isoPGF), a marker of lipid peroxidation, was measured at 1, 2, 4, and 6 weeks of age. Neurodevelopmental outcome at 18 months' corrected age was assessed using the Bayley Scales of Infant Development (BSID)-II.
  
  
  RESULTS
  Significant correlations were found between urinary 8-OHdG at 2 and 4 weeks and the Mental Development Index of the BSID-II. No significant correlation was found between urinary 8-isoPGF and indices of the BSID-II.
  
  
  CONCLUSIONS
  In VLBW infants, urinary 8-OHdG level correlated with mental development rather than psychomotor development at 18 months' corrected age; urinary 8-OHdG might be a predictive marker of neurodevelopmental outcome in VLBW infants.
authors.affiliation: Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Shoji
authors.forename: Naho
authors.initials: N
authors.lastname: Ikeda
authors.forename: Mariko
authors.initials: M
authors.lastname: Hosozawa
authors.forename: Natsuki
authors.initials: N
authors.lastname: Ohkawa
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Matsunaga
authors.forename: Hiroki
authors.initials: H
authors.lastname: Suganuma
authors.forename: Ken
authors.initials: K
authors.lastname: Hisata
authors.forename: Kyoko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D007223:Infant; D019102:Infant, Very Low Birth Weight / Q000378:metabolism* / Q000652:urine; D008297:Male; D009420:Nervous System / Q000254:growth & development*; D018384:Oxidative Stress
chemical_list: C075750:8-epi-prostaglandin F2alpha; D000080242:8-Hydroxy-2'-Deoxyguanosine; D015237:Dinoprost; D003849:Deoxyguanosine
keywords: 8-hydroxy-2″-deoxyguanosine; 8-iso-prostaglandin F2α; Bayley Scales of Infant Development; oxidative stress; very low birthweight