title: Systemic sclerosis with sarcoidosis: case report and review of the published work.
abstract: Sarcoidosis and systemic sclerosis (SSc) rarely coexist. Here, we report a Japanese female SSc patient who developed systemic sarcoidosis. Her SSc was a limited type negative for anti-Scl-70 antibody and positive for anticentromere antibody (ACA). Moreover, we performed a review of the English-language published work that described cases of concurrent SSc and sarcoidosis. Then, we found that most SSc and sarcoidosis concurrent patients positive for anti-Scl-70 antibody were male (77.8%). On the other hand, most patients positive for ACA were female (87.5%). These results suggest some relationships between autoantibody profiles and sex in SSc and sarcoidosis concurrence.
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Senda
authors.forename: Ken
authors.initials: K
authors.lastname: Igawa
authors.forename: Megumi
authors.initials: M
authors.lastname: Nishioka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Murota
authors.forename: Ichiro
authors.initials: I
authors.lastname: Katayama
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood; D004264:DNA Topoisomerases, Type I; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000276:immunology; D012507:Sarcoidosis / Q000150:complications* / Q000276:immunology; D012595:Scleroderma, Systemic / Q000150:complications* / Q000276:immunology; D012727:Sex Characteristics
chemical_list: D000974:Antibodies, Antinuclear; D009687:Nuclear Proteins; C048100:Scl 70 antigen, human; C538950:anticentromere antibody; D004264:DNA Topoisomerases, Type I
keywords: autoantibody; concurrent; sarcoidosis; sex; systemic sclerosis