title: Piperazine side-effects in a patient with pre-existing renal insufficiency.
abstract: Piperazine as an antihelminth has many adverse effects, especially on patients with renal insufficiency. We report the use of piperazine in a girl with a moderately severe kidney disease due to Biedl Bardet syndrome. She developed coma and acute kidney injury due to acute interstitial nephritis (AIN), anemia and thrombocytopenia. The presence of fever, proteinuria, acidosis, anemia, sterile pyuria and non-oliguric renal failure strongly suggested AIN. Her problems abated mostly by discontinuing of piperazine and supportive therapy, except anemia and thrombocytopenia.
authors.affiliation: Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Malaki
mesh_terms: D000208:Acute Disease; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D020788:Bardet-Biedl Syndrome / Q000150:complications / Q000175:diagnosis; D002648:Child; D005260:Female; D006801:Humans; D009395:Nephritis, Interstitial / Q000150:complications / Q000175:diagnosis; D000077489:Piperazine; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects*; D051437:Renal Insufficiency / Q000209:etiology
chemical_list: D000969:Antinematodal Agents; D010879:Piperazines; D000077489:Piperazine