title: Involvement of Arabidopsis HAC family genes in pleiotropic developmental processes.
abstract: With intrinsic acetyltransferase activities, CREB binding protein (CBP)/p300 proteins mediate a variety of physiological events, such as proliferation, differentiation, and apoptosis, by regulating both histones and non-histone proteins. Arabidopsis CBP-type histone acetyltransferase family proteins, HACs, have been found to influence flower by regulating the expression of Flowering Locus C. We recently reported that HAC family genes involved in the ethylene signaling pathway. Thereafter, we systematically analyzed the morphological and developmental phenotypes of all the hac mutant combinations including plant size, root, flower, leaf defects, and late-flowering. Here we reinforce the ubiquitous regulation mechanism of HAC family genes, in which HAC1 plays a dominant role with the synergistic assist of HAC5 and HAC12, but HAC4 slightly alleviates the influence of HAC1 and HAC5.
authors.affiliation: National Institute of Biological Sciences; Beijing, PR China; Department of Molecular Biology and Biochemistry; University of Massachusetts; Amherst, MA USA.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: National Institute of Biological Sciences; Beijing, PR China; Institute of Crop Science; Chinese Academy of Agricultural Sciences; Beijing, PR China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Xu
authors.affiliation: Institute of Crop Science; Chinese Academy of Agricultural Sciences; Beijing, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Institute of Crop Science; Chinese Academy of Agricultural Sciences; Beijing, PR China.
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Li
authors.affiliation: Institute of Crop Science; Chinese Academy of Agricultural Sciences; Beijing, PR China.
authors.forename: Hongchun
authors.initials: H
authors.lastname: Yang
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development*; D029681:Arabidopsis Proteins / Q000235:genetics*; D058685:Genetic Pleiotropy; D051548:Histone Acetyltransferases / Q000235:genetics*
chemical_list: D029681:Arabidopsis Proteins; D051548:Histone Acetyltransferases
keywords: CBP/p300; HAC; development; ethylene; histone acetyltransferase; signaling