title: Severe neutropenia presenting with Candida albicans eyelid abscess in a 1-year-old child.
abstract: A previously healthy 1-year-old boy presented with a right lower eyelid abscess. Oral and topical antibiotics were initiated, and the lesion was drained and explored. Despite medical and surgical treatment, the abscess failed to resolve completely and formed again 1 month later. A second incision and drainage procedure was performed, and Candida albicans grew in cultures. Additional workup revealed severe neutropenia with an absolute neutrophil count of 0.18 k/μl (1.19-7.21 k/μl). The abscess resolved after 2 weeks of oral fluconazole. C. albicans eyelid abscess may be the presenting sign of systemic immunodeficiency.
authors.affiliation: *Cole Eye Institute, Cleveland Clinic; †Center for Human Genetics, University Hospitals Case Medical Center; and ‡Cleveland Clinic Children's Hospital, Cleveland, Ohio, U.S.A.
authors.forename: Bryan R
authors.initials: BR
authors.lastname: Costin
authors.forename: Carrie E
authors.initials: CE
authors.lastname: Costin
authors.forename: Palak B
authors.initials: PB
authors.lastname: Wall
authors.forename: Jedediah I
authors.initials: JI
authors.lastname: McClintic
authors.forename: Charles B
authors.initials: CB
authors.lastname: Foster
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Hackney
authors.forename: Elias I
authors.initials: EI
authors.lastname: Traboulsi
authors.forename: Julian D
authors.initials: JD
authors.lastname: Perry
mesh_terms: D000038:Abscess / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D004322:Drainage; D015821:Eye Infections, Fungal / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005141:Eyelid Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D009503:Neutropenia / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole