title: Long-Term Mortality of 306,868 Patients with Multi-Vessel Coronary Artery Disease: CABG versus PCI.
abstract: BACKGROUND
  Several randomized controlled trials (RCT) have reported no difference in long-term mortality between coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). The purpose of this pooled observational analysis was to compare recent retrospective studies examining long-term survival of patients with multi-vessel coronary artery disease undergoing CABG and PCI.
  
  
  METHODS
  We searched Medline for observational studies comparing long-term (>1 year) survival between CABG and PCI for the treatment of multi-vessel coronary artery disease over the past 10 years.
  
  
  RESULTS
  Eight studies met inclusion criteria. A total of 306,868 patients (155,502 CABG; 151,366 PCI) were identified. Follow-up ranged from 1 to 8 years. Mantel-Haenszel combined hazard ratios (HR) for mortality demonstrated a protective benefit of CABG compared with PCI (HR=0.77, 95%CI=0.75-0.79).
  
  
  CONCLUSIONS
  These findings suggest a long-term survival advantage for CABG compared with PCI in patients with multi-vessel coronary artery disease.
authors.affiliation: East Carolina Heart Institute, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina University, Greenville, NC, USA ; Departmentof Public Health, Brody School of Medicine, East Carolina University, Greenville, NC, USA ; Center for Health Disparities Research, Brody School of Medicine, Greenville, NC, USA.
authors.forename: Jimmy T
authors.initials: JT
authors.lastname: Efird
authors.affiliation: East Carolina Heart Institute, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina University, Greenville, NC, USA ; Departmentof Public Health, Brody School of Medicine, East Carolina University, Greenville, NC, USA ; Center for Health Disparities Research, Brody School of Medicine, Greenville, NC, USA.
authors.forename: Wesley T
authors.initials: WT
authors.lastname: O'Neal
authors.affiliation: East Carolina Heart Institute, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina University, Greenville, NC, USA ; Departmentof Public Health, Brody School of Medicine, East Carolina University, Greenville, NC, USA ; Departmentof General Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA.
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Davies
authors.affiliation: East Carolina Heart Institute, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina University, Greenville, NC, USA ; Center for Health Disparities Research, Brody School of Medicine, Greenville, NC, USA.
authors.forename: Whitney L
authors.initials: WL
authors.lastname: Kennedy
authors.affiliation: Departmentof Public Health, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
authors.forename: Lada N
authors.initials: LN
authors.lastname: Alger
authors.affiliation: Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
authors.forename: Jason B
authors.initials: JB
authors.lastname: O'Neal
authors.affiliation: East Carolina Heart Institute, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
authors.forename: T Bruce
authors.initials: TB
authors.lastname: Ferguson
authors.affiliation: East Carolina Heart Institute, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
authors.forename: Alan P
authors.initials: AP
authors.lastname: Kypson
keywords: CABG; PCI; long-term; survival