title: Rhodium-catalyzed direct C-H bond cyanation of arenes with isocyanide.
abstract: An efficient rhodium-catalyzed regioselective C-H bond cyanation of arenes was developed using tert-butyl isocyanide as the cyanide source. A wide range of (hetero)aryl and cycloalkenyl nitriles could be afforded with high regioselectivity and good functional group tolerance.
authors.affiliation: School of Materials Science and Engineering, Department of Chemistry, Innovative Drug Research Center, Shanghai University , Shanghai 200444, China.
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Hong
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Guangyin
authors.initials: G
authors.lastname: Qian
authors.forename: Qitao
authors.initials: Q
authors.lastname: Tan
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
mesh_terms: D002384:Catalysis; D003486:Cyanides / Q000138:chemical synthesis / Q000737:chemistry*; D003516:Cycloparaffins / Q000138:chemical synthesis / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D003486:Cyanides; D003516:Cycloparaffins; D006571:Heterocyclic Compounds; D009570:Nitriles; C099535:tert-butyl isocyanide; D012238:Rhodium