title: [Dyslipidemia in patients with antiphospholipid syndrome and its association with endothelial dysfunction and atherosclerotic changes in the carotid arteries].
abstract: This article presents data on dyslipidemia and its relationship with endothelial dysfunction and subclinical manifestations of atherosclerotic vascular lesions in patients with antiphospholipid syndrome (APS). The study revealed some features of lipid profile, depending on the variation of APS. The most common disorders of lipid profile among patients with secondary APS (SAPS) was hypertriglyceridemia (55.8%) and an increase in LDL cholesterol level (41.9%), in patients with primary APS (PAPS)--decrease of HDL cholesterol level (35.3%). The correlation analysis suggested that high total cholesterol level, LDL cholesterol level, triglycerid level and low HDL cholesterol level were the predictors of early development of atherosclerotic complications in patients SAPS, while in patients with PAPS predictive value can only have hypertriglyceridemia.
authors.forename: S V
authors.initials: SV
authors.lastname: Shevchuk
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Seheda
authors.forename: I P
authors.initials: IP
authors.lastname: Kuvikova
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism; D001783:Blood Flow Velocity / Q000502:physiology; D002340:Carotid Artery Diseases / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D011237:Predictive Value of Tests; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
chemical_list: D017152:Antibodies, Antiphospholipid; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides