title: Independent control of aging and axon regeneration.
abstract: Axon regeneration capacity often declines with age. One might assume that loss of regeneration is an obvious consequence of organismal aging. However, in the latest issue of Neuron, Byrne et al. (2014) demonstrate that regeneration ability and aging are regulated cell-autonomously within neurons, and can be decoupled.
authors.affiliation: F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Stephane
authors.initials: S
authors.lastname: Belin
authors.affiliation: F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Norsworthy
authors.affiliation: F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: zhigang.he@childrens.harvard.edu.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: He
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D009410:Nerve Degeneration / Q000503:physiopathology*; D009416:Nerve Regeneration / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D007328:Insulin; D007334:Insulin-Like Growth Factor I