title: Retrospective follow up of gross motor development in children using propranolol for treatment of infantile haemangioma at Sydney Children's Hospital.
abstract: Questions have been raised as to whether propranolol, which crosses the blood-brain barrier, when used early in life may have an adverse effect on gross motor development. A retrospective survey asking questions about gross motor development was sent to the families of children who had been prescribed oral propranolol for infantile haemangioma at Sydney Children's Hospital between 2008 and 2013. It was found that of the 84 patients surveyed, four were delayed in walking unassisted. There was a statistically significant influence if the child was taking other medications which included prednisolone, vincristine, omeprazole, ranitidine, salbutamol, Flixotide, Timoptol and antibiotics. This was not further analysed in this study because of the low numbers involved. There was no statistically significant influence of gestational age, birth weight or length of time on propranolol. This study adds to the retrospective data available; however large-scale prospective studies are needed to identify unexpected long-term side-effects.
authors.affiliation: Prince of Wales Hospital, Sydney, New South Wales, Australia.
authors.forename: Kate
authors.initials: K
authors.lastname: Gonski
authors.forename: Orli
authors.initials: O
authors.lastname: Wargon
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D002657:Child Development / Q000187:drug effects / Q000502:physiology*; D005500:Follow-Up Studies; D018324:Hemangioma, Capillary / Q000188:drug therapy*; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D009048:Motor Skills; D009517:New South Wales; D011433:Propranolol / Q000627:therapeutic use*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000188:drug therapy*; D016138:Walking
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol
keywords: gross motor development; infantile haemangioma; propranolol