title: NF-κB Activation in T Helper 17 Cell Differentiation.
abstract: CD28/T cell receptor ligation activates the NF-κB signaling cascade during CD4 T cell activation. NF-κB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-κB activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-κB activation pathway and its effect on Th17 cell differentiation.
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, Korea.
authors.forename: Sang-Heon
authors.initials: SH
authors.lastname: Park
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, Korea.
authors.forename: Gabi
authors.initials: G
authors.lastname: Cho
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, Korea.
authors.forename: Sung-Gyoo
authors.initials: SG
authors.lastname: Park
keywords: Autoimmune; NF-κB; T cell receptor; Th17