title: STEAP4 and insulin resistance.
abstract: Obesity is a multifactorial disease that caused by the interactions between genetic susceptibility genes and environmental cues. Obesity is considered as a major risk factor of insulin resistance. STEAP4 is a novel anti-obesity gene that is significantly down-regulated in adipose tissue of obese patients. Over-expression of STEAP4 can improve glucose uptake and mitochondrial function, and increase insulin sensitivity. STEAP4 expression is regulated by a variety of inflammatory cytokines, hormones, or adipokines. In this review, we discuss function of STEAP4 in regulating insulin resistance in adipose tissue in vivo, as well as in adipocytes in vitro.
authors.affiliation: Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, 611130, Sichuan, People's Republic of China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Chen
authors.forename: Zhiqing
authors.initials: Z
authors.lastname: Huang
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Jia
authors.forename: Guangmang
authors.initials: G
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D015536:Down-Regulation; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D010088:Oxidoreductases / Q000235:genetics* / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D010088:Oxidoreductases; C503310:STEAP4 protein, human