title: [Protective effect of selank on the model of mnestic function violation induced by pharmacological blockade of protein synthesis].
abstract: We have studied the ability of peptide anxiolytic selank (Thr-Lyz-Pro-Arg-Pro-Gly-Pro) to compensate for mnestic dysfunction caused by the administration of actinomycin D, which inhibits protein synthesis by blocking DNA-dependent RNA polymerase. The experiments were performed on white rats with acquired adaptive ability of spatial visual orientation in a 16-door labyrinth. The learning was based on the avoidance of electric skin irritation at alternating sites of escape reaction (site reflex). Selank (0.5 mg/kg, i.p.) prevented or compensated for actinomycin D (250 mg/kg, i.p.) induced violation of the process of acquisition, improvement, and consolidation of memory trace during the development of a complex site reflex. The drug administration also reduced the time required for acquisition of the adaptive ability of spatial visual orientation in the labyrinth and restored the actinomycin D violated process of re-learning upon a change in the alternation of escape sites under free-choice conditions.
authors.forename: I I
authors.initials: II
authors.lastname: Kozlovskiĭ
authors.forename: F Iu
authors.initials: FIu
authors.lastname: Belozertsev
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: M M
authors.initials: MM
authors.lastname: Kozlovskaia
mesh_terms: D000818:Animals; D003609:Dactinomycin / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology*; D014176:Protein Biosynthesis / Q000187:drug effects*; D011500:Protein Synthesis Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics; D051381:Rats; D014796:Visual Perception / Q000187:drug effects*
chemical_list: D009842:Oligopeptides; D011500:Protein Synthesis Inhibitors; D003609:Dactinomycin; C100827:TP 7