title: Designing multiregional trials under the discrete random effects model.
abstract: A discrete random effects model (Lan and Pinheiro, 2012) was proposed recently for multiregional clinical trials for continuous responses. This article elucidates further the application of this model to time-to-event and binary responses. We provide some guidelines on how to design multiregional trials and also show how the same model lends itself naturally to meta-analysis.
authors.affiliation: a Quantitative Decision Strategies , Janssen Research & Development , Raritan , New Jersey , USA.
authors.forename: K-K Gordon
authors.initials: KK
authors.lastname: Lan
authors.forename: José
authors.initials: J
authors.lastname: Pinheiro
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
mesh_terms: D023381:Endpoint Determination / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D015201:Meta-Analysis as Topic; D008962:Models, Theoretical; D015337:Multicenter Studies as Topic / Q000379:methods* / Q000706:statistics & numerical data; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000706:statistics & numerical data; D012107:Research Design / Q000706:statistics & numerical data