title: Bitargeting and ambushing nanotheranostics.
abstract: The main problem in cancer chemotherapy is the cytotoxic side effects of therapeutics on healthy tissues and cells. The targeted drug delivery and nanotechnology are intensively investigated area to find new ways to solve, at least to reduce, these problems. Hereby, we have reported a new method inspired from both conventional military strategies and biorecognition in the body. In this respect, we have produced two fluorescent nano-drug systems with bitargeting and biorecognition properties, recognizing cancer cells and each other. The multiplexed nanostructures were interacted with HL-60 cells to show their efficiency for bitargeting, ambushing, timed, and double-controlled cancer cell apoptosis.
authors.affiliation: Department of Chemistry, Anadolu University , Eskişehir , Turkey.
authors.forename: Rıdvan
authors.initials: R
authors.lastname: Say
authors.forename: Lokman
authors.initials: L
authors.lastname: Uzun
authors.forename: Suzan
authors.initials: S
authors.lastname: Yazar
authors.forename: Adil
authors.initials: A
authors.lastname: Denizli
authors.forename: Deniz
authors.initials: D
authors.lastname: Hür
authors.forename: Filiz
authors.initials: F
authors.lastname: Yılmaz
authors.forename: Arzu
authors.initials: A
authors.lastname: Ersöz
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D016503:Drug Delivery Systems; D018922:HL-60 Cells; D006801:Humans; D007069:Ifosfamide / Q000494:pharmacology*; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology; D009251:NADPH-Ferrihemoprotein Reductase / Q000138:chemical synthesis; D053758:Nanoparticles / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D010787:Photosensitivity Disorders; D058105:Polymerization; D011355:Prodrugs / Q000494:pharmacology*; D045663:Quantum Dots / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D011355:Prodrugs; D009251:NADPH-Ferrihemoprotein Reductase; D007069:Ifosfamide