title: Intra-operative peritoneal lavage for colorectal cancer.
abstract: Free cancer cells can be detected in peritoneal fluid at the time of colorectal surgery. Peritoneal lavage in colorectal surgery for cancer is not used in routine, and the prognostic significance of intraperitoneal free cancer cells (IPCC) remains unclear. Data concerning the technique of peritoneal lavage to detect IPCC and its timing regarding colorectal resection are scarce. However, positive IPCC might be the first step of peritoneal spread in colorectal cancers, which could lead to early specific treatments. Because of the important heterogeneity of IPCC determination in reported studies, no treatment have been proposed to patients with positive IPCC. Herein, we provide an overview of IPCC detection and its impact on recurrence and survival, and we suggest further multi-institutional studies to evaluate new treatment strategies.
authors.affiliation: Guillaume Passot, Kayvan Mohkam, Eddy Cotte, Olivier Glehen, Departement of General and Surgical Oncology, Hospices Civils de Lyon, 69495 Pierre Bénite, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Passot
authors.affiliation: Guillaume Passot, Kayvan Mohkam, Eddy Cotte, Olivier Glehen, Departement of General and Surgical Oncology, Hospices Civils de Lyon, 69495 Pierre Bénite, France.
authors.forename: Kayvan
authors.initials: K
authors.lastname: Mohkam
authors.affiliation: Guillaume Passot, Kayvan Mohkam, Eddy Cotte, Olivier Glehen, Departement of General and Surgical Oncology, Hospices Civils de Lyon, 69495 Pierre Bénite, France.
authors.forename: Eddy
authors.initials: E
authors.lastname: Cotte
authors.affiliation: Guillaume Passot, Kayvan Mohkam, Eddy Cotte, Olivier Glehen, Departement of General and Surgical Oncology, Hospices Civils de Lyon, 69495 Pierre Bénite, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Glehen
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001202:Ascitic Fluid / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D007432:Intraoperative Period; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D010533:Peritoneal Lavage / Q000379:methods*; D010534:Peritoneal Neoplasms / Q000473:pathology; D010537:Peritoneum / Q000473:pathology; D011379:Prognosis; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: Colorectal cancer; Free intraperitoneal cells; Immunocytochemistry; Peritoneal carcinomatosis