title: Dyslipidemia and outcome in patients with acute ischemic stroke.
abstract: OBJECTIVE
  To study the relationship between dyslipidemia and outcome in patients with acute ischemic stroke.
  
  
  METHODS
  Data about 1 568 patients with acute ischemic stroke were collected from 4 hospitals in Shandong Province from January 2006 to December 2008. National Institute of Health Stroke Scale (NIHSS) >10 at discharge or death was defined as the outcome. Effect of dyslipidemia on outcome in patients with acute ischemic stroke was analyzed by multivariate logistic regression analysis and propensity score-adjusted analysis, respectively.
  
  
  RESULTS
  The serum levels of TC, LDL-C, and HDL-C were significantly associated with the outcome in patients with acute ischemic stroke. Multivariate logistic regression analysis and propensity score-adjusted analysis showed that the ORs and 95% CIs were 3.013 (1.259, 7.214)/2.655 (1.298, 5.43), 3.157 (1.306, 7.631)/3.405 (1.621, 7.154), and 0.482 (0.245, 0.946)/0.51 (0.282, 0.921), respectively, for patients with acute ischemic stroke. Hosmer-Lemeshow goodness-of-ﬁt test showed no significant difference in observed and predicted risk in patients with acute ischemic stroke (chi-square=8.235, P=0.411).
  
  
  CONCLUSIONS
  Serum levels of TC, LDL-C, and HDL-C are positively related with the outcome in patients with acute ischemic stroke.
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Neurology, Chinese PLA 88 Hospital, Tai'an 271000, Shandong, China.
authors.forename: Jin Tao
authors.initials: JT
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Chinese PLA 88 Hospital, Tai'an 271000, Shandong, China.
authors.forename: Wen Qing
authors.initials: WQ
authors.lastname: Liu
authors.affiliation: Department of Neurology, Chinese PLA 88 Hospital, Tai'an 271000, Shandong, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Kong
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Tan
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Yong Hong
authors.initials: YH
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000097:blood / Q000150:complications* / Q000401:mortality*; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D050171:Dyslipidemias / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002784:Cholesterol
keywords: Acute ischemic stroke; Dyslipidemia; Multivariate logistic regression analysis; Outcome; Propensity score-adjusted analysis