title: Preparation of chitosan-TPP microspheres as resveratrol carriers.
abstract: Resveratrol (3,4',5-trihydroxy-trans-stilbene)-loaded chitosan-sodium tripolyphosphate (TPP) microspheres using high (310 to 375 kDa) and medium (190 to 310 kDa) molecular weight chitosan and TPP in varying concentrations were produced to improve resveratrol bioavailability. A 450 μm nozzle encapsulator was used to produce the microspheres. The mean microsphere particle size was between 160 and 206 μm, and exhibited a narrower size distribution as the TPP solution concentration increased. The encapsulation efficiency increased from 94% to 99% with a decrease in chitosan concentration from 1% to 0.5% and a decrease in crystallinity of the microspheres. FTIR data showed a polyelectrolyte interaction between chitosan and TPP. X-ray diffraction patterns were matched up with DSC and FTIR, which shows decrease of crystallinity and enhancement of hydrogen bonding with TPP concentration. An increase in the concentration of TPP solution from 1% to 3% led to a lower initial burst of resveratrol release. These results suggest that chitosan-TPP microspheres could be used as a potential delivery system to control the release of resveratrol.
authors.affiliation: Korea Food Research Instit, 1201-62 Anyangpangyo-Ro, Baekhyun-Dong, Bundang-Ku, Songnam-Si, Kyunggi-Do 463-746, Republic of Korea.
authors.forename: Ah Ra
authors.initials: AR
authors.lastname: Cho
authors.forename: Yong Gi
authors.initials: YG
authors.lastname: Chun
authors.forename: Bum Keun
authors.initials: BK
authors.lastname: Kim
authors.forename: Dong June
authors.initials: DJ
authors.lastname: Park
mesh_terms: D002214:Capsules; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D006860:Hydrogen Bonding; D008863:Microspheres; D008970:Molecular Weight; D010316:Particle Size; D010936:Plant Extracts / Q000008:administration & dosage*; D011122:Polyphosphates / Q000737:chemistry*; D000077185:Resveratrol; D017550:Spectroscopy, Fourier Transform Infrared; D013267:Stilbenes / Q000008:administration & dosage*; D014961:X-Ray Diffraction
chemical_list: D002214:Capsules; D004337:Drug Carriers; D010936:Plant Extracts; D011122:Polyphosphates; D013267:Stilbenes; D048271:Chitosan; C005692:triphosphoric acid; D000077185:Resveratrol
keywords: chitosan; controlled release; microspheres; resveratrol; sodium tripolyphosphate