title: Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs.
abstract: The performance of the cerebral state index (CSI) in reflecting different levels of isoflurane anaesthesia was evaluated in ten cats subjected to four end-tidal isoflurane concentrations (EtIso), each maintained for 15 minutes (0.8%, 1.2%, 1.6%, or 2.0% EtIso). The CSI, hemodynamic data, ocular reflexes, and eye position were recorded for each EtIso concentration. Pharmacodynamic analysis of CSI with EtIso was performed, as well as prediction probability analysis with a clinical scale based on the eye reflexes. The CSI values showed great variability. Between all parameters, burst suppression ratio showed the better fitting with the sigmoidal concentration-effect model (R (2) = 0.93) followed by CSI (R (2) = 0.82) and electromyographic activity (R (2) = 0.79). EtIso was the variable with better prediction of the clinical scale of anaesthesia (prediction probability value of 0.94). Although the CSI values decrease with increasing isoflurane concentrations, the huge variability in CSI values may be a strong limitation for its use in cats and it seems to be no better than EtIso as a predictor of clinical signs.
authors.affiliation: Centro de Investigação em Ciências Veterinárias, Faculdade de Medicina Veterinária, Universidade Lusófona de Humanidades e Tecnologia, Campo Grande 376, 1749-024 Lisboa, Portugal.
authors.forename: Joana R
authors.initials: JR
authors.lastname: Sousa
authors.affiliation: Hospital Veterinário do Porto, Travessa Silva Porto 174, 4250-475 Porto, Portugal.
authors.forename: Lénio
authors.initials: L
authors.lastname: Ribeiro
authors.affiliation: REQUIMTE, Laboratório de Toxicologia, Faculdade de Farmácia da Universidade do Porto, Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal.
authors.forename: Aura
authors.identifier: 0000-0002-2044-6320
authors.initials: A
authors.lastname: Silva
authors.affiliation: Centro de Investigação em Ciências Veterinárias, Faculdade de Medicina Veterinária, Universidade Lusófona de Humanidades e Tecnologia, Campo Grande 376, 1749-024 Lisboa, Portugal.
authors.forename: David A
authors.initials: DA
authors.lastname: Ferreira