title: An enzyme-based reversible CNOT logic gate realized in a flow system.
abstract: An enzyme system organized in a flow device was used to mimic a reversible Controlled NOT (CNOT) gate with two input and two output signals. Reversible conversion of NAD(+) and NADH cofactors was used to perform a XOR logic operation, while biocatalytic hydrolysis of p-nitrophenyl phosphate resulted in an Identity operation working in parallel. The first biomolecular realization of a CNOT gate is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.
authors.affiliation: Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13676, USA. ekatz@clarkson.edu.
authors.forename: Fiona
authors.initials: F
authors.lastname: Moseley
authors.forename: Jan
authors.initials: J
authors.lastname: Halámek
authors.forename: Friederike
authors.initials: F
authors.lastname: Kramer
authors.forename: Arshak
authors.initials: A
authors.lastname: Poghossian
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Schöning
authors.forename: Evgeny
authors.initials: E
authors.lastname: Katz
mesh_terms: D055162:Biocatalysis; D004798:Enzymes / Q000378:metabolism*; D006868:Hydrolysis; D009243:NAD / Q000378:metabolism*; D009596:Nitrophenols / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000378:metabolism
chemical_list: D004798:Enzymes; D009596:Nitrophenols; D009943:Organophosphorus Compounds; D009243:NAD; C008644:nitrophenylphosphate