title: Bad and worse: neural systems underlying reappraisal of high- and low-intensity negative emotions.
abstract: One of the most effective strategies for regulating emotional responses is cognitive reappraisal. While prior work has made great strides in characterizing reappraisal's neural mechanisms and behavioral outcomes, the key issue of how regulation varies as a function of emotional intensity remains unaddressed. We compared the behavioral and neural correlates of reappraisal of high- and low-intensity emotional responses using functional magnetic resonance imaging (fMRI). We found that successful reappraisal of both high- and low-intensity emotions depends upon recruitment of dorsomedial (dmPFC) as well as left dorsolateral (dlPFC) and ventrolateral (vlPFC) prefrontal cortex. However, reappraisal of high-intensity emotions more strongly activated left dlPFC, and in addition, activated right lateral and dorsomedial PFC regions not recruited by low-intensity reappraisal. No brain regions were more strongly recruited during reappraisal of low when compared with high-intensity emotions. Taken together, these results suggest that reappraisal of high-intensity emotion requires greater cognitive resources as evidenced by quantitative and qualitative differences in prefrontal recruitment. These data have implications for understanding how and when specific PFC systems are needed to regulate different types of emotional responses.
authors.affiliation: Department of Psychology, Columbia University, New York, NY and Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA ochsner@psych.columbia.edu.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Silvers
authors.affiliation: Department of Psychology, Columbia University, New York, NY and Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.
authors.forename: Jochen
authors.initials: J
authors.lastname: Weber
authors.affiliation: Department of Psychology, Columbia University, New York, NY and Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.
authors.forename: Tor D
authors.initials: TD
authors.lastname: Wager
authors.affiliation: Department of Psychology, Columbia University, New York, NY and Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.
authors.forename: Kevin N
authors.initials: KN
authors.lastname: Ochsner
mesh_terms: D000679:Amygdala / Q000502:physiology; D001519:Behavior / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000502:physiology; D011999:Recruitment, Neurophysiological / Q000502:physiology; D055815:Young Adult
keywords: emotional intensity; reappraisal