title: Biodegradable polymer Biolimus-eluting stent (Nobori®) for the treatment of coronary artery lesions: review of concept and clinical results.
abstract: First-generation drug-eluting stents have raised concerns regarding the risk of late and very late stent thrombosis compared with bare metal stents and require prolonged dual antiplatelet therapy. Despite extensive investigations, the physiopathology of these late events remains incompletely understood. Aside from patient- and lesion-related risk factors, stent polymer has been cited as one of the potential causes. In fact, the persistence of durable polymer after complete drug release has been shown to be responsible for local hypersensitivity and inflammatory reactions. Third-generation drug-eluting stents with more biocompatible or biodegradable polymers have subsequently been developed to address this problem. In this article, we evaluate and discuss the concept and clinical results (safety and efficacy) of a third-generation drug-eluting stent with biodegradable polymer: the Nobori® stent.
authors.affiliation: Centre Hémodynamique et Unité des Soins Intensifs de Cardiologie, Hôpital Cardiologique, Centre Hospitalier Régional et Universitaire de Lille, Lille, France ; Faculté de Médecine de Lille, Lille, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Schurtz
authors.affiliation: Centre Hémodynamique et Unité des Soins Intensifs de Cardiologie, Hôpital Cardiologique, Centre Hospitalier Régional et Universitaire de Lille, Lille, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Delhaye
authors.affiliation: Centre Hémodynamique et Unité des Soins Intensifs de Cardiologie, Hôpital Cardiologique, Centre Hospitalier Régional et Universitaire de Lille, Lille, France ; Faculté de Médecine de Lille, Lille, France.
authors.forename: Christopher
authors.initials: C
authors.lastname: Hurt
authors.affiliation: Centre Hémodynamique et Unité des Soins Intensifs de Cardiologie, Hôpital Cardiologique, Centre Hospitalier Régional et Universitaire de Lille, Lille, France ; Faculté de Médecine de Lille, Lille, France.
authors.forename: Henri
authors.initials: H
authors.lastname: Thieuleux
authors.affiliation: Centre Hémodynamique et Unité des Soins Intensifs de Cardiologie, Hôpital Cardiologique, Centre Hospitalier Régional et Universitaire de Lille, Lille, France ; Faculté de Médecine de Lille, Lille, France ; Unité INSERM UMR744, Institut Pasteur de Lille, Lille, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Lemesle
keywords: antiplatelet therapy; percutaneous coronary intervention; stent thrombosis