title: Microfluidic-based generation of size-controlled, biofunctionalized synthetic polymer microgels for cell encapsulation.
abstract: Cell and islet microencapsulation in synthetic hydrogels provides an immunoprotective and cell-supportive microenvironment. A microfluidic strategy for the genaration of biofunctionalized, synthetic microgel particles with precise control over particle size and molecular permeability for cell and protein delivery is presented. These engineered capsules support high cell viability and function of encapsulated human stem cells and islets.
authors.affiliation: Woodruff School of Mechanical Engineering, 315 Ferst Dr NW, Atlanta, GA, 30332, USA; Petit Institute for Bioengineering and Bioscience, 311 Ferst Dr NW, Atlanta, GA, 30332, USA.
authors.forename: Devon M
authors.initials: DM
authors.lastname: Headen
authors.forename: Guillaume
authors.initials: G
authors.lastname: Aubry
authors.forename: Hang
authors.initials: H
authors.lastname: Lu
authors.forename: Andrés J
authors.initials: AJ
authors.lastname: García
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D007515:Islets of Langerhans / Q000166:cytology*; D008301:Maleimides / Q000737:chemistry; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D020100:Hydrogels; D008301:Maleimides; D011108:Polymers; C043592:maleimide; D011092:Polyethylene Glycols
keywords: cell microencapsulation; hydrogels; microfluidics; pancreatic islets; synthetic microgel