title: Role of diffusion-weighted MRI in differentiation of hepatic abscesses from non-infected fluid collections.
abstract: OBJECTIVE
  To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in the differentiation of hepatic abscesses from non-infected fluid collections.
  
  
  METHODS
  In this retrospective study, 22 hepatic abscesses and 27 non-infected hepatic fluid collections were examined in 27 patients who underwent abdominal MRI including DW-MRI. Two independent observers reviewed T2-weighted + DW-MRI and T2-weighted + contrast-enhanced T1-weighted (CET1W) images in two sessions. Detection rates and confidence levels were calculated and compared using McNemar's and Wilcoxon's signed rank tests, respectively. Apparent diffusion coefficient (ADC) values of abscesses and non-infected fluid collections were compared using the t-test. Receiver operating characteristic (ROC) curves were constructed.
  
  
  RESULTS
  There was no statistically significant difference in the accuracy of detecting abscesses using T2-weighted + DW-MRI (both observers: 21/22, 95.5%) versus T2-weighted + CET1W images (observer 1: 21/22, 95.5%; observer 2: 22/22, 100%; p < 0.01). Mean ADC values were significantly lower with abscesses versus non-infected fluid collections (0.83 ± 0.24 versus 2.25 ± 0.61 × 10(-3) mm(2)/s; p < 0.001). With ROC analysis there was good discrimination of abscess from non-infected fluid collections at a threshold ADC value of 1.36 × 10(-3) mm(2)/s.
  
  
  CONCLUSIONS
  DW-MRI allows qualitative and quantitative differentiation of abscesses from non-infected fluid collections in the liver.
authors.affiliation: Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Schmid-Tannwald
authors.affiliation: Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich, Germany.
authors.forename: C M
authors.initials: CM
authors.lastname: Schmid-Tannwald
authors.affiliation: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Morelli
authors.affiliation: Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Neumann
authors.affiliation: Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich, Germany.
authors.forename: M F
authors.initials: MF
authors.lastname: Reiser
authors.affiliation: Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Nikolaou
authors.affiliation: Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich, Germany. Electronic address: carsten.rist@me.com.
authors.forename: C
authors.initials: C
authors.lastname: Rist
mesh_terms: D003287:Contrast Media; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005122:Exudates and Transudates; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008100:Liver Abscess / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012015:Reference Standards; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA