title: Hepatoprotective activity of Oxalis corniculata L. ethanolic extract against paracetamol induced hepatotoxicity in Wistar rats and its in vitro antioxidant effects.
abstract: Oxalis corniculata is well known for its medicinal properties like anti-inflammatory, digestive, diuretic, antibacterial, antiseptic etc. The present study focuses on the ability of O. corniculata to alleviate liver damage caused by over dose of paracetamol. Antioxidant activity of O. corniculata was evaluated using the free radical scavenging activity of 1, 1-diphenyl-2- picrylhydrazyl radicals, total anti oxidant capacity by phosphomolybdenum method and total phenolic content was also evaluated. The ethanolic extract of whole plant of O. corniculata (OC, 500 microg/mL, po) significantly reduced 1, 1-diphenyl-2- picrylhydrazyl radicals. This dose also caused significant reduction (62.67%) in malondialdehyde levels of murine hepatic tissues. The antioxidant capacity of OC was comparable to that of standard ascorbic acid and showed 53.5 microg of phenol/mg OC. Rats pre-treated with OC for 4 days showed significant reduction in the serum enzymes such as glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline phosphatase, serum bilirubin and showed almost normal histological liver architecture of the treated groups compared to paracetamol induced hepatic damage group, indicating its hepatoprotective and antioxidant potential.
authors.affiliation: Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India.
authors.forename: G
authors.initials: G
authors.lastname: Sreejith
authors.affiliation: N S S College, Nilamel, Kollam 691 535, India.
authors.forename: M
authors.initials: M
authors.lastname: Jayasree
authors.affiliation: Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India.
authors.forename: P G
authors.initials: PG
authors.lastname: Latha
authors.affiliation: Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India.
authors.forename: S R
authors.initials: SR
authors.lastname: Suja
authors.affiliation: Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India.
authors.forename: S
authors.initials: S
authors.lastname: Shyamal
authors.affiliation: Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India.
authors.forename: V J
authors.initials: VJ
authors.lastname: Shine
authors.affiliation: Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India.
authors.forename: G I
authors.initials: GI
authors.lastname: Anuja
authors.affiliation: Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India.
authors.forename: S
authors.initials: S
authors.lastname: Sini
authors.affiliation: Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India.
authors.forename: P
authors.initials: P
authors.lastname: Shikha
authors.affiliation: Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India.
authors.forename: N M
authors.initials: NM
authors.lastname: Krishnakumar
authors.affiliation: Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India.
authors.forename: V
authors.initials: V
authors.lastname: Vilash
authors.affiliation: Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India.
authors.forename: S
authors.initials: S
authors.lastname: Shoumya
authors.affiliation: Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India.
authors.forename: S
authors.initials: S
authors.lastname: Rajasekharan
mesh_terms: D000082:Acetaminophen / Q000633:toxicity; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D000431:Ethanol; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D020011:Protective Agents; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D010636:Phenols; D010936:Plant Extracts; D020011:Protective Agents; D000082:Acetaminophen; D000431:Ethanol