title: Capsid proteins of enveloped viruses as antiviral drug targets.
abstract: Viral proteins have enabled the design of selective and efficacious treatments for viral diseases. While focus in this area has been on viral enzymes, it appears that multifunctional viral proteins may be even more susceptible to small molecule interference. As exemplified by HIV capsid, small molecule inhibitors can bind to multiple binding sites on the capsid protein and induce or prevent protein interactions and conformational changes. Resistance selection is complicated by the fact that the capsid proteins have to engage in different protein interactions at different times of the life cycle. Viral capsid assembly and disassembly have therefore emerged as highly sensitive processes that could deliver a new generation of antiviral agents across viral diseases.
authors.affiliation: Novira Therapeutics, Inc., 3805 Old Easton Road, Doylestown, PA 18902, United States. Electronic address: kklumpp@noviratherapeutics.com.
authors.forename: Klaus
authors.initials: K
authors.lastname: Klumpp
authors.affiliation: University of Grenoble Alpes-EMBL-CNRS, Unit for Virus Host-Cell Interactions, 6 rue Jules Horowitz, 38042, France.
authors.forename: Thibaut
authors.initials: T
authors.lastname: Crépin
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology*; D036022:Capsid Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D006801:Humans
chemical_list: D019380:Anti-HIV Agents; D036022:Capsid Proteins