title: Porous Pd nanoparticles with high photothermal conversion efficiency for efficient ablation of cancer cells.
abstract: Nanoparticle (NP) mediated photothermal effect shows great potential as a noninvasive method for cancer therapy treatment, but the development of photothermal agents with high photothermal conversion efficiency, small size and good biocompatibility is still a big challenge. Herein, we report Pd NPs with a porous structure exhibiting enhanced near infrared (NIR) absorption as compared to Pd nanocubes with a similar size (almost two-fold enhancement with a molar extinction coefficient of 6.3 × 10(7) M(-1) cm(-1)), and the porous Pd NPs display monotonically rising absorbance from NIR to UV-Vis region. When dispersed in water and illuminated with an 808 nm laser, the porous Pd NPs give a photothermal conversion efficiency as high as 93.4%, which is comparable to the efficiency of Au nanorods we synthesized (98.6%). As the porous Pd NPs show broadband NIR absorption (650-1200 nm), this allows us to choose multiple laser wavelengths for photothermal therapy. In vitro photothermal heating of HeLa cells in the presence of porous Pd NPs leads to 100% cell death under 808 nm laser irradiation (8 W cm(-2), 4 min). For photothermal heating using 730 nm laser, 70% of HeLa cells were killed after 4 min irradiation at a relative low power density of 6 W cm(-2). These results demonstrated that the porous Pd nanostructure is an attractive photothermal agent for cancer therapy.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, PKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry, Peking University, Beijing 100871, China. sun@pku.edu.cn yan@pku.edu.cn.
authors.forename: Jia-Wen
authors.initials: JW
authors.lastname: Xiao
authors.forename: Shi-Xuan
authors.initials: SX
authors.lastname: Fan
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Ling-Dong
authors.initials: LD
authors.lastname: Sun
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Zheng
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Yan
mesh_terms: D016923:Cell Death / Q000187:drug effects; D006367:HeLa Cells; D006358:Hot Temperature; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D010165:Palladium / Q000737:chemistry / Q000494:pharmacology; D010789:Phototherapy / Q000379:methods*
chemical_list: D010165:Palladium