title: Diabetes mellitus and risk of all-cause mortality among patients with tuberculosis in the state of Georgia, 2009-2012.
abstract: OBJECTIVE
  To estimate the association between diabetes mellitus (DM) and all-cause mortality during tuberculosis (TB) treatment.
  
  
  METHODS
  From 2009 to 2012, a retrospective cohort study among reported TB cases in Georgia was conducted. Patients aged 16 years or older were classified by DM and human immunodeficiency virus (HIV) status at the time of TB diagnosis and followed during TB treatment to assess mortality. Hazard ratios were used to estimate the association between DM and death.
  
  
  RESULTS
  Among 1325 patients with TB disease, 151 (11.4%) had DM, 147 (11.1%) were HIV-infected, and seven (0.5%) had both DM and HIV. Patients with TB-DM were more likely to have cavitary lung disease compared with those with TB alone (51.0% vs. 34.7%) and those with TB-HIV were more likely to have military/disseminated disease (12.9% vs. 3.4%) and resistance to rifampin or isoniazid (21.8% vs. 9.0%) compared with those without HIV infection (P < .05). In multivariable analysis, DM was not associated with death during TB treatment (hazard ratio, 1.22; 95% confidence interval, 0.70-2.12) or any death (adjusted odds ratio, 1.05; 95% confidence interval, 0.60-1.84).
  
  
  CONCLUSIONS
  Among TB patients in Georgia, the prevalence of comorbid DM and coinfection with HIV was nearly identical. In adjusted models, TB patients with DM did not have increased risk of all-cause mortality.
authors.affiliation: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA. Electronic address: mjmagee@emory.edu.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Magee
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
authors.forename: Mary
authors.initials: M
authors.lastname: Foote
authors.affiliation: Division of Health Protection, Georgia Department of Public Health, Atlanta, GA.
authors.forename: David M
authors.initials: DM
authors.lastname: Maggio
authors.affiliation: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
authors.forename: Penelope P
authors.initials: PP
authors.lastname: Howards
authors.affiliation: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA.
authors.forename: K M Venkat
authors.initials: KM
authors.lastname: Narayan
authors.affiliation: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA.
authors.forename: Henry M
authors.initials: HM
authors.lastname: Blumberg
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Ray
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
authors.forename: Russell R
authors.initials: RR
authors.lastname: Kempker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use; D002423:Cause of Death; D060085:Coinfection / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality; D015897:Comorbidity; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D005845:Georgia / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology / Q000401:mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D057566:Self Report; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents
keywords: Diabetes mellitus; Georgia; HIV; Mortality; Tuberculosis