title: Prepregnancy body mass index and weight change on postpartum diabetes risk among gestational diabetes women.
abstract: OBJECTIVE
  To evaluate the effects of prepregnancy BMI and weight change from prepregnancy to postpartum on postpartum type 2 diabetes (T2D) risk among women with gestational diabetes (GDM).
  
  
  METHODS
  A retrospective cohort study in 1,263 GDM women at 1-5 years after delivery was performed. Cox proportional hazards regression models were used to evaluate the association of prepregnancy BMI and weight change with T2D and prediabetes risks.
  
  
  RESULTS
  The multivariable-adjusted hazard ratios based on different levels of prepregnancy BMI (<23, 23-24.9, 25-29.9, and ≥30 kg/m(2) ) were 1.00, 1.77, 2.35, and 6.54 (Ptrend  < 0.001) for incident T2D, and 1.00, 1.46, 1.87, and 1.79 (Ptrend  < 0.001) for incident prediabetes, respectively. Compared with women with stable weight (±3 kg), those with weight gain ≥7 kg had an 86% and a 32% increased risk of diabetes and prediabetes, and those with weight loss ≥3 kg had a 45% decreased risk of prediabetes. The positive associations of prepregnancy BMI with incident diabetes and prediabetes risk were persistent in women with different levels of weight change (<3 kg and ≥3 kg).
  
  
  CONCLUSIONS
  Prepregnancy obesity and excessive weight gain from prepregnancy to postpartum increase postpartum diabetes and prediabetes risks among GDM women.
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin, China.
authors.forename: Huikun
authors.initials: H
authors.lastname: Liu
authors.forename: Cuiping
authors.initials: C
authors.lastname: Zhang
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhang
authors.forename: Leishen
authors.initials: L
authors.lastname: Wang
authors.forename: Junhong
authors.initials: J
authors.lastname: Leng
authors.forename: Dongdong
authors.initials: D
authors.lastname: Liu
authors.forename: Han
authors.initials: H
authors.lastname: Fang
authors.forename: Weiqin
authors.initials: W
authors.lastname: Li
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Yu
authors.forename: Xilin
authors.initials: X
authors.lastname: Yang
authors.forename: Ling
authors.initials: L
authors.lastname: Dong
authors.forename: Gang
authors.initials: G
authors.lastname: Hu
mesh_terms: D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D016640:Diabetes, Gestational / Q000453:epidemiology*; D002149:Energy Intake; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D009765:Obesity / Q000150:complications; D049590:Postpartum Period / Q000502:physiology*; D011236:Prediabetic State / Q000453:epidemiology; D011247:Pregnancy; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D007328:Insulin