title: The effect of conjugated linoleic acids and omega-3 fatty acids supplementation on lipid profile in atherosclerosis.
abstract: BACKGROUND
  Cardiovascular diseases (CVD) are the most serious cause of mortality in developed and developing countries. Epidemiological studies indicated that dyslipidemia is the major risk factor of CVD. Dyslipidemia can be modified either by proper lifestyle or medical intervention or by the combination of both. Conjugated linoleic acids (CLA) and ω3 fatty acids have beneficial effects on plasma lipids and lipoproteins. The aim of this study was to evaluate the effect of CLA and omega-3 fatty acids (ω-3 fatty acids) supplementation on lipid profile in atherosclerosis patient.
  
  
  METHODS
  This study was a 2-month clinical randomized trial. Ninety atherosclerotic patients with angiographically diagnosed coronary atherosclerosis who were referred to Emam Reza Heart Clinic of Shiraz University of Medical Sciences from February to march 2011 were selected if they fulfilled the inclusion criteria. The participants were randomly classified into 3 groups receiving 3 g/d CLA or 1 920 mg/d ω3 or placebo for 2 months. High-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglycerides (TG), and total cholesterol were measured before and after the intervention. This study was a two-month clinical randomized trial.
  
  
  RESULTS
  Data were analyzed using SPSS software (SPSS Inc, Chicago, version19). Although CLA did not appear to have a significant effect on TG, ω3 supplementation significantly reduced TG level. Consumption of CLA and ω3 supplementation did not significantly affect HDL cholesterol, LDL cholesterol, and total cholesterol.
  
  
  CONCLUSIONS
  ω3 supplementation significantly reduced TG level but CLA and ω3 did not show significant changes in other indices of lipid profile in atherosclerotic patients.
authors.affiliation: Nutrition Department, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Eftekhari
authors.affiliation: Nutrition Department, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Fereshte
authors.initials: F
authors.lastname: Aliasghari
authors.affiliation: Heart Department, School of Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad Ali Babaei
authors.initials: MA
authors.lastname: Beigi
authors.affiliation: Epidemiology Department, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Jafar
authors.initials: J
authors.lastname: Hasanzadeh
keywords: Atherosclerosis; conjugated linoleic acids; lipid profile; omega-3 fatty acids