title: [Effect of sodium fluoroacetate on Ehrlich solid tumor and autochthonous sarcoma growth in mice].
abstract: Due to biochemical characteristics of toxic action of fluoroacetate on energetics and metabolism of cells, including tumor cells, it was interesting to testify sodium fluoroacetate (SFA) for its antitumor activity in vivo. We have estimated that SFA significantly inhibits growth of Ehrlich tumor carcinoma. In experiments with autochthonous induced by benzo[a]pyrene subcutaneous tumors, SFA was not active in monotherapy regime, though potentiated antitumor effect of cyclophosphamide, significantly increasing the relative number of mice with stabilized or decreased tumor volume as well as the duration of this effect. The data obtained render basis for additional studies of mechanism of antitumor effect of SFA.
authors.forename: I V
authors.initials: IV
authors.lastname: Anikin
authors.forename: N V
authors.initials: NV
authors.lastname: Goncharov
authors.forename: M L
authors.initials: ML
authors.lastname: Tyndyk
authors.forename: N G
authors.initials: NG
authors.lastname: Voĭtenko
authors.forename: G B
authors.initials: GB
authors.lastname: Pliss
authors.forename: M A
authors.initials: MA
authors.lastname: Zabezhinskiĭ
authors.forename: I G
authors.initials: IG
authors.lastname: Popovich
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D001564:Benzo(a)pyrene; D002286:Carcinoma, Ehrlich Tumor / Q000139:chemically induced / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D005463:Fluoroacetates / Q000494:pharmacology*; D051379:Mice; D012513:Sarcoma, Experimental / Q000188:drug therapy*; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D005463:Fluoroacetates; D001564:Benzo(a)pyrene; D003520:Cyclophosphamide; C014815:fluoroacetic acid