title: Rickettsial meningitis.
abstract: Rickettsial infections are common in southern Europe and the most frequent and lethal type is Mediterranean spotted fever, caused by Rickettsia conorii. The disease is usually characterised by the classical triad of fever, eschar and rash, and is generally a mild disease in children. Complications including neurological involvement are rarely described. We report an unusual case of meningitis in an 18-year-old man, presenting during summer with fever and persistent headache. The cerebrospinal fluid analysis revealed increased cellularity (107 cells/μL), hypoglycorrhachia (50% of glycaemia) and hyperproteinorrhachia (284 mg/dL). Rickettsial infection was confirmed by serology and the patient was treated with doxycycline, with a favourable outcome. The patient's pet squirrel and/or associated vectors might be involved in the transmission of Rickettsia spp. This case underlines the importance of a high clinical suspicion and the benefits of early empirical treatment when facing compatible epidemiological contexts.
authors.affiliation: Department of Pediatrics, Hospital de Dona Estefânia, Lisbon, Portugal.
authors.forename: Inês
authors.initials: I
authors.lastname: Salva
authors.forename: Rita
authors.initials: R
authors.lastname: de Sousa
authors.forename: Catarina
authors.initials: C
authors.lastname: Gouveia
mesh_terms: D000293:Adolescent; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000276:immunology*; D001907:Boutonneuse Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D004318:Doxycycline / Q000627:therapeutic use; D006801:Humans; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D057805:Pets / Q000382:microbiology; D020114:Rickettsia conorii / Q000276:immunology*; D012589:Sciuridae
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D004318:Doxycycline