title: Expression of p53 protein in the endometrial polyp in postmenopausal women.
abstract: OBJECTIVE
  To evaluate p53 protein expression in the endometrial polyp and compare with adenocarcinoma and atrophic endometrium of postmenopausal women.
  
  
  METHODS
  Ninety-eight postmenopausal women were included in this study and divided into three groups related to histopathologic diagnosis: Group A--endometrial adenocarcinoma (n = 40), Group B--endometrial polyp (n = 38), and Group C--endometrial atrophy (n = 20). The length of this study was from 1990 to 2004. The endometrial samples were collected from hysteroscopic biopsy or surgery then processed for histopathologic routine. One thousand cells of each histological section were evaluated for immunohistochemical analysis using p53 antibodies. The ANOVA test was performed for the statistical analysis.
  
  
  RESULTS
  The expression of p53 in adenocarcinoma samples was the highest. The expression of polyp was positive when associated to hyperplasia without atypia. All samples of atrophic endometrial were negative.
  
  
  CONCLUSIONS
  The present data suggested that presence of hyperplasia in the endometrial polyp is factor to increase the expression of p53.
authors.affiliation: Department of Gynecology, Federal University of São Paulo Escola Paulista de Medicina, São Paulo, Brazil. luizcava@uol.com.br
authors.forename: L C de Albuquerque
authors.initials: LC
authors.lastname: Neto
authors.affiliation: Department of Obstetrics and Gynecology, Facultade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: J M
authors.initials: JM
authors.lastname: Soares
authors.affiliation: Department of Gynecology, Federal University of São Paulo Escola Paulista de Medicina, São Paulo, Brazil.
authors.forename: M G
authors.initials: MG
authors.lastname: Giusa-Chiferi
authors.affiliation: Department of Gynecology, Federal University of São Paulo Escola Paulista de Medicina, São Paulo, Brazil.
authors.forename: W J
authors.initials: WJ
authors.lastname: Gonçalves
authors.affiliation: Department of Obstetrics and Gynecology, Facultade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: E C
authors.initials: EC
authors.lastname: Baracat
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry*; D000368:Aged; D001284:Atrophy / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000378:metabolism; D004714:Endometrial Hyperplasia / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000737:chemistry*; D004717:Endometrium / Q000737:chemistry* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011127:Polyps / Q000737:chemistry* / Q000473:pathology; D017698:Postmenopause / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000032:analysis* / Q000378:metabolism; D014591:Uterine Diseases / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53