title: Preparation of vincristine sulfate-loaded poly (butylcyanoacrylate) nanoparticles modified with pluronic F127 and evaluation of their lymphatic tissue targeting.
abstract: In order to improve the lymphatic targeting efficiency of anti-cancer agent vincristine sulfate (VCR), the poly (butylcyanoacrylate) nanoparticles (VCR-PBCA-NPs) were prepared by emulsion polymerization and modified superficially with Pluronic F127. These prepared nanoparticles with (F127-VCR-PBCA-NPs) and without surface modification (VCR-PBCA-NPs) were characterized and their lymphatic targeting efficiencies were evaluated in vitro and in vivo. The results showed that VCR was released more sustained from both kinds of VCR-loaded nanoparticles, compared with the VCR solution. The up-taking efficiency of VCR into raji cells was enhanced by F127-VCR-PBCA-NPs, compared with the VCR-PBCA-NPs or VCR solution. Lower clearance (CL) of VCR from the systemic circulation and higher lymphatic targeting efficiency of VCR were observed for F127-VCR-PBCA-NPs than the VCR-PBCA-NPs or VCR solution, and F127-VCR-PBCA-NPs showed greater antitumor efficacy than the VCR-PBCA-NPs or VCR solution in the human Burkitt's lymphoma (raji)-bearing nude mice. These findings suggest that superficially modified nanoscale carriers might be promising vehicles for chemotherapeutic agents in the treatments of metastatic tumors and malignant lymphoma.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, Shanghai University of Traditional Chinese Medicine , Shanghai , PR China.
authors.forename: Rong
authors.initials: R
authors.lastname: Tan
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Niu
authors.forename: Jihui
authors.initials: J
authors.lastname: Zhao
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Nianping
authors.initials: N
authors.lastname: Feng
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D002460:Cell Line; D003487:Cyanoacrylates / Q000737:chemistry*; D004659:Enbucrilate; D006801:Humans; D008221:Lymphoid Tissue / Q000187:drug effects*; D008297:Male; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D020442:Poloxamer / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D014750:Vincristine / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003487:Cyanoacrylates; D020442:Poloxamer; D014750:Vincristine; D004659:Enbucrilate
keywords: Lymphatic targeting; Pluronic F127; pharmacokinetics; polybutylcyanoacrylate nanoparticles; tissue distribution; vincristine sulfate