title: Neutrophil-to-lymphocyte ratio and in-hospital mortality in patients with acute heart failure.
abstract: OBJECTIVE
  Previous studies have demonstrated the role of inflammation in acute heart failure. The neutrophil-to-lymphocyte ratio was found to be a useful inflammatory marker for predicting adverse outcomes. We hypothesized that an elevated neutrophil-to-lymphocyte ratio would be associated with increased mortality in acute heart failure patients.
  
  
  METHODS
  The study cohort consisted of 167 acute heart failure patients with an ejection fraction <50%. The primary endpoint was in-hospital mortality, and the patients were divided into two groups according to in-hospital mortality.
  
  
  RESULTS
  In a multivariate regression analysis, including baseline demographic, clinical, and biochemical covariates, the neutrophil to lymphocyte ratio remained an independent predictor of mortality (OR 1.156, 95% CI 1.001 - 1.334, p = 0.048).
  
  
  CONCLUSIONS
  In conclusion, an elevated neutrophil-to-lymphocyte ratio seems to be a predictor of short-term mortality in patients with acute heart failure and a reduced left ventricular ejection fraction.
authors.forename: Murat
authors.initials: M
authors.lastname: Turfan
authors.forename: Ercan
authors.initials: E
authors.lastname: Erdoğan
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Tasal
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Vatankulu
authors.forename: Parviz
authors.initials: P
authors.lastname: Jafarov
authors.forename: Osman
authors.initials: O
authors.lastname: Sönmez
authors.forename: Gökhan
authors.initials: G
authors.lastname: Ertaş
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bacaksız
authors.forename: Omer
authors.initials: O
authors.lastname: Göktekin
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D011379:Prognosis; D012044:Regression Analysis; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013318:Stroke Volume / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D015415:Biomarkers