title: Predicting onset of chronic lung disease using cord blood cytokines.
abstract: BACKGROUND
  Applicability of cord blood interleukin-6 (IL-6) and interleukin-8 (IL-8) as markers for early prediction of the onset of chronic lung disease (CLD) due to intrauterine infection was investigated in the present study.
  
  
  METHODS
  Eighty very low-birthweight infants with chorioamnionitis were divided into two groups: the CLD group (42 patients) and the non-CLD group (38 patients), according to the presence or absence of CLD, and the clinical background and cord blood IL-6 and IL-8 levels in each group were compared and investigated.
  
  
  RESULTS
  The CLD group had significantly longer duration of mechanical ventilation and hospitalization (P < 0.05) and significantly higher IL-6 and IL-8 (P < 0.01) than the non-CLD group. Using the receiver operating characteristic curves of CLD onset for both IL-6 and IL-8, the cut-off value of IL-6 for predicting onset of CLD was 48.0 pg/mL, and its sensitivity and specificity were 76% and 96%, respectively. The cut-off value for IL-8 was 66.0 pg/mL, and its sensitivity and specificity were 71% and 82%, respectively.
  
  
  CONCLUSIONS
  The cord blood levels of both IL-6 and IL-8 were significantly higher in the CLD group, indicating that both IL-6 and IL-8 are useful predictors of onset of CLD.
authors.affiliation: Division of Pediatrics, Maternal and Perinatal Care Center, Aizenbashi Hospital, Osaka, Japan.
authors.forename: Daishi
authors.initials: D
authors.lastname: Takao
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ibara
authors.forename: Takuya
authors.initials: T
authors.lastname: Tokuhisa
authors.forename: Chie
authors.initials: C
authors.lastname: Ishihara
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Maede
authors.forename: Takako
authors.initials: T
authors.lastname: Matsui
authors.forename: Hironobu
authors.initials: H
authors.lastname: Tokumasu
authors.forename: Kyoko
authors.initials: K
authors.lastname: Sato
authors.forename: Eiji
authors.initials: E
authors.lastname: Hirakawa
authors.forename: Chika
authors.initials: C
authors.lastname: Kabayama
authors.forename: Masakatu
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D017668:Age of Onset; D002908:Chronic Disease; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008171:Lung Diseases / Q000097:blood* / Q000175:diagnosis*; D011237:Predictive Value of Tests
chemical_list: C508606:CXCL8 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8
keywords: chorioamnionitis; chronic lung disease; cytokines; inflammation; neonate