title: Chemotherapy for Generalized Infantile Myofibromatosis With Visceral Involvement.
abstract: Infantile myofibromatosis (IM) is most commonly limited to cutaneous lesions that resolve spontaneously. However, generalized IM with visceral involvement, which has a reported mortality rate as high as 73%, has been successfully treated with a combination of methotrexate and vinblastine. Here we report the further efficacy of low-dose methotrexate and vinblastine in 2 pediatric patients with IM and visceral involvement and review the literature describing chemotherapy for these patients.
authors.affiliation: *University of Texas Southwestern Medical School †Department of Pediatrics, Division of Hematology-Oncology Departments of §Radiology ¶Pathology ∥Molecular Biology, University of Texas Southwestern Medical Center at Dallas ‡The Center for Cancer and Blood Disorders and Children's Medical Center Dallas, Dallas, TX.
authors.forename: Susan Y
authors.initials: SY
authors.lastname: Wu
authors.forename: Timothy L
authors.initials: TL
authors.lastname: McCavit
authors.forename: Kevin
authors.initials: K
authors.lastname: Cederberg
authors.forename: Rene L
authors.initials: RL
authors.lastname: Galindo
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Leavey
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D018224:Myofibromatosis / Q000151:congenital* / Q000188:drug therapy / Q000473:pathology; D014750:Vincristine / Q000627:therapeutic use*; D014781:Viscera / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D014750:Vincristine; D008727:Methotrexate