title: Elevated 1-h post-load plasma glucose levels in subjects with normal glucose tolerance are associated with unfavorable inflammatory profile.
abstract: Glucose tolerant subjects with 1-h post-load glucose ≥155 mg/dl (NGT-1 h-high) are at increased risk for type 2 diabetes (T2DM). Prospective studies showed that chronic subclinical inflammation is a predictor of T2DM. In this study, we aimed to evaluate the inflammatory profile in NGT-1 h-high subjects as compared with individuals with 1-h post-load glucose <155 mg/dl (NGT-1 h-low). To this end, an oral glucose tolerance tests (OGTT) were performed in 1,099 nondiabetic whites. Cardio-metabolic risk factors including high-sensitivity C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), fibrinogen, and complement C3 (C3) were determined. Of the 1,099 subjects examined, 497 had NGT-1 h-low, 154 had NGT-1 h-high, 158 had isolated impaired fasting glucose (IFG), and 290 had impaired glucose tolerance (IGT). As compared with NGT-1 h-low, NGT-1 h-high and IGT subjects exhibited significantly higher hsCRP, ESR, fibrinogen, and C3 levels. Notably, hsCRP, ESR, and C3 were also significantly higher as compared with IFG individuals. In a logistic regression analysis adjusted for age and gender, NGT-1 h-high and IGT subjects had a 1.8-fold increased risk of having the highest value of the Inflammatory Score. These data suggest that a value of a 1-h OGTT glucose ≥155 mg/dl may be helpful to identify a subset of normal glucose tolerance individuals at risk for chronic subclinical inflammation, a predictor of T2DM, and cardiovascular diseases.
authors.affiliation: Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100, Viale Europa, Catanzaro, Italy, sesti@unicz.it.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sesti
authors.forename: Teresa Vanessa
authors.initials: TV
authors.lastname: Fiorentino
authors.forename: Elena
authors.initials: E
authors.lastname: Succurro
authors.forename: Maria
authors.initials: M
authors.lastname: Perticone
authors.forename: Franco
authors.initials: F
authors.lastname: Arturi
authors.forename: Angela
authors.initials: A
authors.lastname: Sciacqua
authors.forename: Francesco
authors.initials: F
authors.lastname: Perticone
mesh_terms: D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases; D001786:Blood Glucose / Q000378:metabolism*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000378:metabolism; D002908:Chronic Disease; D003176:Complement C3 / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism*; D008297:Male; D055442:Metabolome; D008875:Middle Aged; D011236:Prediabetic State / Q000150:complications / Q000378:metabolism*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D003176:Complement C3; D005340:Fibrinogen; D002097:C-Reactive Protein