title: Emerging opportunities for the combination of molecularly targeted drugs with radiotherapy.
abstract: Recent drug discovery developments in the field of small molecule targeted agents have led to much interest in combining these with radiotherapy. There are good preclinical data to suggest this approach worthy of investigation and in this review we discuss how this has translated into recent clinical trials. The outcome of clinical trials investigating radiotherapy/targeted drug combinations published in the last 5 years is discussed, as are trials in progress. The perceived future opportunities and challenges in the development of this exciting area are considered.
authors.affiliation: Manchester Pharmacy School, University of Manchester, Manchester, UK; Targeted Therapy Group, Institute of Cancer Sciences, University of Manchester, Manchester, UK. Electronic address: emma.searle@manchester.ac.uk.
authors.forename: E J
authors.initials: EJ
authors.lastname: Searle
authors.affiliation: Targeted Therapy Group, Institute of Cancer Sciences, University of Manchester, Manchester, UK.
authors.forename: T M
authors.initials: TM
authors.lastname: Illidge
authors.affiliation: Manchester Pharmacy School, University of Manchester, Manchester, UK.
authors.forename: I J
authors.initials: IJ
authors.lastname: Stratford
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000068579:Celecoxib; D059248:Chemoradiotherapy / Q000379:methods*; D002986:Clinical Trials as Topic; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology; D066246:ErbB Receptors / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000532:radiotherapy; D011720:Pyrazoles / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D013449:Sulfonamides / Q000494:pharmacology; D042461:Vascular Endothelial Growth Factor A / Q000187:drug effects / Q000528:radiation effects
chemical_list: D000970:Antineoplastic Agents; D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D011838:Radiation-Sensitizing Agents; D013449:Sulfonamides; D042461:Vascular Endothelial Growth Factor A; D066246:ErbB Receptors; D000068579:Celecoxib
keywords: Molecularly targeted drugs; radiation; radiosensitisers; radiotherapy