title: Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.
abstract: New lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo.
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Anesthesiology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA, 02115, USA.
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Dong
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Eltoukhy
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Alabi
authors.forename: Omar F
authors.initials: OF
authors.lastname: Khan
authors.forename: Omid
authors.initials: O
authors.lastname: Veiseh
authors.forename: J Robert
authors.initials: JR
authors.lastname: Dorkin
authors.forename: Sasilada
authors.initials: S
authors.lastname: Sirirungruang
authors.forename: Hao
authors.initials: H
authors.lastname: Yin
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Tang
authors.forename: Jeisa M
authors.initials: JM
authors.lastname: Pelet
authors.forename: Delai
authors.initials: D
authors.lastname: Chen
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xue
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Anderson
mesh_terms: D000818:Animals; D015870:Gene Expression; D020868:Gene Silencing; D006367:HeLa Cells; D006801:Humans; D008055:Lipids / Q000737:chemistry* / Q000493:pharmacokinetics; D051379:Mice; D008810:Mice, Inbred C57BL; D049329:Nanostructures / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D014162:Transfection / Q000379:methods*; D014227:Triazines / Q000737:chemistry
chemical_list: D008055:Lipids; D034741:RNA, Small Interfering; D014227:Triazines
keywords: gene expression; gene silencing; lipid-like nanomaterials; plasmid DNA; siRNA