title: The effect of food on the pharmacokinetics of oral fluralaner in dogs.
abstract: BACKGROUND
  Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. The pharmacokinetics of orally administered drugs may be influenced by feeding. This study investigated the influence of concurrent feeding on fluralaner pharmacokinetics.
  
  
  METHODS
  Twelve fasted or fed beagles received a single oral administration of 25 mg fluralaner/kg body weight in a chewable tablet. Plasma samples were collected at multiple post-treatment time points for fluralaner concentration analysis. Clinical observations were performed on all dogs at regular intervals throughout the study.
  
  
  RESULTS
  Fluralaner was readily absorbed in fasted and fed dogs administered at a dose of 25 mg/kg BW with a similar mean tmax for both groups. In fed dogs, AUC and C(max) were increased compared to fasted dogs by a factor of 2.5 and 2.1 respectively. The difference in AUC and C(max) between the fed and fasted groups was statistically significant. No adverse events were observed following oral fluralaner administration to fasted and fed dogs.
  
  
  CONCLUSIONS
  Fluralaner is absorbed to a considerable extent in fasted and fed dogs. Administration of fluralaner chewable tablets with food significantly increases bioavailability.
authors.affiliation: MSD Animal Health Innovation GmbH, Zur Propstei, 55270 Schwabenheim, Germany. feli.walther@msd.de.
authors.forename: Feli M
authors.initials: FM
authors.lastname: Walther
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Allan
authors.forename: Rainer K A
authors.initials: RK
authors.lastname: Roepke
authors.forename: Martin C
authors.initials: MC
authors.lastname: Nuernberger
mesh_terms: D056810:Acaricides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D000284:Administration, Oral; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001835:Body Weight; D004285:Dogs / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005260:Female; D005502:Food; D018565:Food-Drug Interactions; D065569:Gastrointestinal Absorption; D007306:Insecticides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D007555:Isoxazoles / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D012449:Safety; D013607:Tablets
chemical_list: C000591860:A1443 compound; D056810:Acaricides; D000977:Antiparasitic Agents; D007306:Insecticides; D007555:Isoxazoles; D013607:Tablets