title: Laser ablation as focal therapy for prostate cancer.
abstract: OBJECTIVE
  Focal laser ablation (FLA) is an emerging treatment paradigm for prostate cancer that aims to successfully eradicate disease while also reducing the risk of side-effects compared with whole-gland therapies.
  
  
  RESULTS
  Preclinical and phase I clinical trials for low-risk prostate cancer have shown that FLA produces accurate, predictable, and reproducible ablation zones with negligible injury to the surrounding tissues. Because FLA is magnetic resonance compatible, the procedure can be monitored with real-time feedback to optimize targeted treatment of cancerous foci and minimize quality-of-life side-effects. The oncologic efficacy of MRI-guided FLA is currently being evaluated in ongoing phase II clinical trials.
  
  
  CONCLUSIONS
  FLA is a well tolerated and feasible therapy for low-risk prostate cancer, and the oncologic efficacy of this treatment modality is currently under investigation in phase II clinical trials at several institutions.
authors.affiliation: aPritzker School of Medicine bDepartment of Radiology cSection of Urology, University of Chicago, Chicago, Illinois, USA.
authors.forename: Hannah
authors.initials: H
authors.lastname: Wenger
authors.forename: Ambereen
authors.initials: A
authors.lastname: Yousuf
authors.forename: Aytekin
authors.initials: A
authors.lastname: Oto
authors.forename: Scott
authors.initials: S
authors.lastname: Eggener
mesh_terms: D000818:Animals; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods; D053783:Magnetic Resonance Imaging, Interventional; D008297:Male; D059351:Organ Sparing Treatments; D011237:Predictive Value of Tests; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*; D025321:Surgery, Computer-Assisted; D016896:Treatment Outcome