title: Understanding innovations in the evolving practice of blood and crystalloid cardioplegia.
abstract: The use of cardioplegia solution has substantially increased the safety of cardiac surgery. It protects the myocardium by inducing a rapid and complete diastolic arrest, minimizing myocardial energy requirements, preventing ischaemic damage during the arrest phase and minimizing or preventing reperfusion injury once coronary blood flow is restored. This article is a summary of important information that has accumulated in the literature about cardioplegia and describes how our understanding of cardioplegia has evolved. The basic principles of myocardial ischaemia and reperfusion injury and how they relate to myocardial protection are described. Blood and crystalloid cardioplegia are compared with respect to biochemical and physiological differences. Recent patient demographic changes, with surgeons operating on older, more complex patients who have more severe and diffuse disease, are discussed. This cohort of patients potentially requires prolonged elective ischaemia; hence, improved myocardial protection would be of benefit. We highlight areas of study that have demonstrated a new concept of myocardial protection, known as polarized arrest. Many pharmacological agents have been shown (in experimental studies) to have the ability to induce a polarized arrest and to provide improved protection.
authors.affiliation: National Heart & Lung Institute, Imperial College London, London, UK kunalb16@yahoo.co.uk.
authors.forename: K P
authors.initials: KP
authors.lastname: Bhakri
authors.affiliation: National Heart & Lung Institute, Imperial College London, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Mulholland
authors.affiliation: National Heart & Lung Institute, Imperial College London, London, UK.
authors.forename: P P
authors.initials: PP
authors.lastname: Punjabi
mesh_terms: D000367:Age Factors; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D006348:Cardiac Surgical Procedures / Q000379:methods*; D003326:Coronary Circulation / Q000187:drug effects*; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium; D017680:Potassium Compounds / Q000627:therapeutic use*
chemical_list: D017680:Potassium Compounds; C018369:potassium cardioplegic solution
keywords: cardiac arrest; cardioplegia; hyperkalaemia; ischaemic pre-conditioning; myocardial protection