title: Polyphenol intake in elderly people is associated with lipid oxidative damage.
abstract: OBJECTIVE
  We hypothesized an association between physiological amounts of different classes and subclasses of polyphenol from a subject's regular diet and lipid peroxidation.
  
  
  METHODS
  Diet was assessed through direct observation and a semiquantitative food frequency questionnaire. Daily polyphenol intake, total as well as subgroups, and plasma malondialdehyde (MDA) were determined together with other variables used as covariates (age, sex, energy intake, Quetelet index, plasma glucose, cholesterol and triglycerides, and tobacco use) in 159 institutionalized elderly subjects (68 men, 91 women) with a mean age of 73.1 years.
  
  
  RESULTS
  Flavonoid intake was inversely associated with MDA in a multiple regression analysis. The potential effect of flavonoids was mainly ascribed to flavanols. A diet score based on the 5 dietary components previously identified as the major contributors to the intake of flavanols was developed. None of the food components was associated with MDA individually, but the overall diet score was inversely associated in a logistic regression analysis.
  
  
  CONCLUSIONS
  This study represents one of the few attempts to date to evaluate the impact of phenol intake on oxidative damage. Flavonoids intake must be promoted to reduce the negative health effects of oxidative stress in elderly people.
authors.affiliation: a Departamento de Biología Funcional, Área de Fisiología, Facultad de Medicina , Universidad de Oviedo , Oviedo , SPAIN.
authors.forename: Sonia
authors.initials: S
authors.lastname: González
authors.forename: Adriana
authors.initials: A
authors.lastname: Cuervo
authors.forename: Cristina
authors.initials: C
authors.lastname: Lasheras
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004032:Diet; D004034:Diet Surveys; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D059808:Polyphenols / Q000008:administration & dosage
chemical_list: D008055:Lipids; D059808:Polyphenols; D008315:Malondialdehyde