title: Comparative effects of gastric bypass and sleeve gastrectomy on plasma osteopontin concentrations in humans.
abstract: BACKGROUND
  Bariatric surgery (BS) has proven to be an effective treatment for morbid obesity. Osteopontin (OPN) is a proinflammatory cytokine involved in the development of obesity. The aim of our study was to determine the effect of weight loss following BS on circulating levels of OPN in humans.
  
  
  METHODS
  Body composition and circulating concentrations of OPN and markers of bone metabolism were determined in obese patients who underwent Roux-en-Y gastric bypass (RYGB; n = 40) or sleeve gastrectomy (SG; n = 11).
  
  
  RESULTS
  Patients who underwent RYGB or SG showed decreased body weight (P < 0.001) and body fat percentage (P < 0.001) as well as lower insulin resistance. However, plasma OPN levels were significantly increased after RYGB (P < 0.001) but remained unchanged following SG (P = 0.152). Patients who underwent RYGB also showed significantly increased C-terminal telopeptide of type-I collagen (ICTP) (P < 0.01) and osteocalcin (P < 0.001) while bone mineral density tended to decrease (P = 0.086). Moreover, OPN concentrations were positively correlated with the bone resorption marker ICTP after surgery. On the other hand, patients who underwent SG showed significantly increased ICTP levels (P < 0.05), and the change in OPN was positively correlated with the change in ICTP and negatively with the change in vitamin D after surgery (P < 0.05).
  
  
  CONCLUSIONS
  RYGB increased circulating OPN levels, while they remained unaltered after SG. The increase in OPN levels after RYGB could be related to the increased bone resorption in relation to its well-known effects on bone of this malabsorptive procedure in comparison to the merely restrictive SG.
authors.affiliation: Metabolic Research Laboratory, Clínica Universidad de Navarra, Irunlarrea 1, 31008, Pamplona, Spain.
authors.forename: Andoni
authors.initials: A
authors.lastname: Lancha
authors.forename: Rafael
authors.initials: R
authors.lastname: Moncada
authors.forename: Víctor
authors.initials: V
authors.lastname: Valentí
authors.forename: Amaia
authors.initials: A
authors.lastname: Rodríguez
authors.forename: Victoria
authors.initials: V
authors.lastname: Catalán
authors.forename: Sara
authors.initials: S
authors.lastname: Becerril
authors.forename: Beatriz
authors.initials: B
authors.lastname: Ramírez
authors.forename: Leire
authors.initials: L
authors.lastname: Méndez-Giménez
authors.forename: María J
authors.initials: MJ
authors.lastname: Gil
authors.forename: Fernando
authors.initials: F
authors.lastname: Rotellar
authors.forename: Secundino
authors.initials: S
authors.lastname: Fernández
authors.forename: Javier
authors.initials: J
authors.lastname: Salvador
authors.forename: Gema
authors.initials: G
authors.lastname: Frühbeck
authors.forename: Javier
authors.initials: J
authors.lastname: Gómez-Ambrosi
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D015519:Bone Density; D002097:C-Reactive Protein / Q000032:analysis; D024042:Collagen Type I / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005743:Gastrectomy / Q000379:methods*; D015390:Gastric Bypass; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D053495:Osteopontin / Q000097:blood*; D010455:Peptides / Q000097:blood; D014807:Vitamin D / Q000097:blood; D015431:Weight Loss
chemical_list: D024042:Collagen Type I; D007328:Insulin; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D053495:Osteopontin; D014807:Vitamin D; D005340:Fibrinogen; D002097:C-Reactive Protein; D000469:Alkaline Phosphatase