title: miR-146a G>C polymorphisms and risk of hepatocellular carcinoma in a Chinese population.
abstract: MicroRNAs (miRNAs) are thought to have a role in cancer development. We investigated the association among miR-146a G>C genetic variations, hepatitis B (HBV), and C (HCV) infection, and risk of hepatocellular carcinoma (HCC). Unconditional logistical regression analysis suggested that the miR-146a GG genotype and G allele carried a 2.10- (95 % confidence interval (CI)=1.03-4.37) and 1.42-fold (95 % CI=1.07-1.92) increased HCC risk, respectively. HBV-positive subjects carrying the miR-146a GG genotype (odds ratio (OR)=2.95, 95 % CI=1.31-6.81) and G allele (OR=1.65, 95 % CI=1.15-2.58) had an increased risk of HCC. However, the miR-146a GG genotype and G allele did not carry a significantly enhanced risk of HCC in either hepatitis-negative or HCV-infected subjects. miR-146a G>C polymorphisms appear to influence susceptibility to HCC, especially in HBV-infected patients.
authors.affiliation: Department of Surgical Oncology (Interventional Therapy), Shandong Tumor Hospital and Institute, Jinan, 250117, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Cong
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.forename: Wen-Zhe
authors.initials: WZ
authors.lastname: Bu
authors.forename: Jin-Peng
authors.initials: JP
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.forename: Jin-Long
authors.initials: JL
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs