title: Effect of feeding graded doses of Citrinin on clinical and teratology in female Wistar rats.
abstract: Citrinin is the one of the well-known mycotoxins, which is possibly spread all over the world. The graded doses of citrinin (1, 3 and 5 ppm CIT in feed) in female Wistar rats 10 weeks prior to mating, during mating and during organogenesis resulted in resorptions and post implantation losses, decreased fetal body weights and crown-rump lengths in fetuses of all groups. Various developmental anomalies recorded in fetuses of treated rats included gross (wrist drop, curled tail, stretched forelimb, subcutaneous haematoma), skeletal (incomplete ossification of skull bones, incomplete fusion of vertebral bodies, complete and partial agenesis of sternaebrae, metacarpals, metatarsals and phalanges, fused ribs and swing out ribs) and visceral (internal and external hydrocephalus, cerebellar hypoplasia, microphthalmia, roundening of heart, contracted kidneys, dilated renal pelvis and cryptorchid testes). The results suggest that CIT has adverse effects on fetal development which may be due to the longer bioavailability of citrinin in the animals.
authors.affiliation: Division of Pathology Indian Veterinary Research Institute, Izatnagar 243 122, India drndsingh@gmail.com
authors.forename: N D
authors.initials: ND
authors.lastname: Singh
authors.affiliation: Division of Pathology Indian Veterinary Research Institute, Izatnagar 243 122, India
authors.forename: A K
authors.initials: AK
authors.lastname: Sharma
authors.affiliation: Division of Pathology Indian Veterinary Research Institute, Izatnagar 243 122, India
authors.forename: R D
authors.initials: RD
authors.lastname: Patil
authors.affiliation: Division of Pathology Indian Veterinary Research Institute, Izatnagar 243 122, India
authors.forename: S
authors.initials: S
authors.lastname: Rahman
authors.affiliation: Division of Pathology Indian Veterinary Research Institute, Izatnagar 243 122, India
authors.forename: G D
authors.initials: GD
authors.lastname: Leishangthem
authors.affiliation: Division of Pathology Indian Veterinary Research Institute, Izatnagar 243 122, India
authors.forename: M
authors.initials: M
authors.lastname: Kumar
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D002953:Citrinin / Q000008:administration & dosage / Q000009:adverse effects*; D020964:Embryo Loss / Q000139:chemically induced / Q000473:pathology*; D047108:Embryonic Development / Q000187:drug effects; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D008297:Male; D009183:Mycotoxins / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D018600:Teratology
chemical_list: D009183:Mycotoxins; D002953:Citrinin