title: Adenovirus type 4 and 7 vaccination or adenovirus type 4 respiratory infection elicits minimal cross-reactive antibody responses to nonhuman adenovirus vaccine vectors.
abstract: Antivector immunity may limit the immunogenicity of adenovirus vector vaccines. We tested sera from individuals immunized with adenovirus type 4 and 7 (Ad4 and Ad7, respectively) vaccine or naturally infected with Ad4 for their ability to neutralize a panel of E1-deleted human and chimpanzee adenoviruses (ChAd). Small statistically significant increases in titers to ChAd63, ChAd3, human Ad35, and human Ad5 were observed. Neutralizing antibodies elicited by Ad4 infection or immunization results in a small amount of adenovirus cross-reactivity.
authors.affiliation: U.S. Military Malaria Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Paris
authors.forename: Robert A
authors.initials: RA
authors.lastname: Kuschner
authors.forename: Leonard
authors.initials: L
authors.lastname: Binn
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Thomas
authors.forename: Stefano
authors.initials: S
authors.lastname: Colloca
authors.forename: Alfredo
authors.initials: A
authors.lastname: Nicosia
authors.forename: Riccardo
authors.initials: R
authors.lastname: Cortese
authors.forename: Robert T
authors.initials: RT
authors.lastname: Bailer
authors.forename: Nancy
authors.initials: N
authors.lastname: Sullivan
authors.forename: Richard A
authors.initials: RA
authors.lastname: Koup
mesh_terms: D000257:Adenoviridae Infections / Q000276:immunology*; D062705:Adenovirus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D000260:Adenoviruses, Human / Q000276:immunology*; D000261:Adenoviruses, Simian / Q000276:immunology*; D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D003429:Cross Reactions; D005822:Genetic Vectors / Q000276:immunology*; D006801:Humans; D002679:Pan troglodytes
chemical_list: D062705:Adenovirus Vaccines; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral