title: The clock gene Period1 regulates innate routine behaviour in mice.
abstract: Laboratory mice are well capable of performing innate routine behaviour programmes necessary for courtship, nest-building and exploratory activities although housed for decades in animal facilities. We found that in mice inactivation of the clock gene Period1 profoundly changes innate routine behaviour programmes like those necessary for courtship, nest building, exploration and learning. These results in wild-type and Period1 mutant mice, together with earlier findings on courtship behaviour in wild-type and period-mutant Drosophila melanogaster, suggest a conserved role of Period-genes on innate routine behaviour. Additionally, both per-mutant flies and Period1-mutant mice display spatial learning and memory deficits. The profound influence of Period1 on routine behaviour programmes in mice, including female partner choice, may be independent of its function as a circadian clock gene, since Period1-deficient mice display normal circadian behaviour.
authors.affiliation: Dr. Senckenbergische Anatomie, Institut für Anatomie III, Goethe-University, , Theodor-Stern-Kai 7, 60590 Frankfurt, Germany, Institute for Cardiovascular Physiology, Goethe-University, , Theodor-Stern-Kai 7, 60596 Frankfurt, Germany, Institute for Cell Biology and Neuroscience, Goethe-University, , Max-von-Laue-Straße 13, 60438 Frankfurt, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Bechstein
authors.forename: Nils-Jörn
authors.initials: NJ
authors.lastname: Rehbach
authors.forename: Gowzekan
authors.initials: G
authors.lastname: Yuhasingham
authors.forename: Christoph
authors.initials: C
authors.lastname: Schürmann
authors.forename: Melanie
authors.initials: M
authors.lastname: Göpfert
authors.forename: Manfred
authors.initials: M
authors.lastname: Kössl
authors.forename: Erik
authors.initials: E
authors.lastname: Maronde
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003380:Courtship; D005260:Female; D007323:Instinct; D007858:Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D051379:Mice; D009425:Nesting Behavior / Q000502:physiology; D056950:Period Circadian Proteins / Q000235:genetics / Q000378:metabolism*; D014828:Vocalization, Animal / Q000502:physiology
chemical_list: C539023:Per1 protein, mouse; D056950:Period Circadian Proteins
keywords: courtship; nest building; novelty; rearing; ultrasonic vocalization