title: Can plant biotechnology help break the HIV-malaria link?
abstract: The population of sub-Saharan Africa is at risk from multiple, poverty-related endemic diseases. HIV and malaria are the most prevalent, but they disproportionately affect different groups of people, i.e. HIV predominantly affects sexually-active adults whereas malaria has a greater impact on children and pregnant women. Nevertheless, there is a significant geographical and epidemiological overlap which results in bidirectional and synergistic interactions with important consequences for public health. The immunosuppressive effects of HIV increase the risk of infection when individuals are exposed to malaria parasites and also the severity of malaria symptoms. Similarly, acute malaria can induce a temporary increase in the HIV viral load. HIV is associated with a wide range of opportunistic infections that can be misdiagnosed as malaria, resulting in the wasteful misuse of antimalarial drugs and a failure to address the genuine cause of the disease. There is also a cumulative risk of toxicity when antiretroviral and antimalarial drugs are given to the same patients. Synergistic approaches involving the control of malaria as a strategy to fight HIV/AIDS and vice versa are therefore needed in co-endemic areas. Plant biotechnology has emerged as a promising approach to tackle poverty-related diseases because plant-derived drugs and vaccines can be produced inexpensively in developing countries and may be distributed using agricultural infrastructure without the need for a cold chain. Here we explore some of the potential contributions of plant biotechnology and its integration into broader multidisciplinary public health programs to combat the two diseases in developing countries.
authors.affiliation: Department of Plant Production and Forestry Science, School of Agrifood and Forestry Science and Engineering (ETSEA), University of Lleida-Agrotecnio Center, Lleida, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Vamvaka
authors.affiliation: TRM Ltd, PO Box 93, York YO43 3WE, United Kingdom.
authors.forename: R M
authors.initials: RM
authors.lastname: Twyman
authors.affiliation: Department of Plant Production and Forestry Science, School of Agrifood and Forestry Science and Engineering (ETSEA), University of Lleida-Agrotecnio Center, Lleida, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Christou
authors.affiliation: Department of Plant Production and Forestry Science, School of Agrifood and Forestry Science and Engineering (ETSEA), University of Lleida-Agrotecnio Center, Lleida, Spain. Electronic address: teresa.capell@pvcf.udl.cat.
authors.forename: T
authors.initials: T
authors.lastname: Capell
mesh_terms: D000962:Antimalarials / Q000378:metabolism / Q000627:therapeutic use; D001709:Biotechnology; D003906:Developing Countries; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008288:Malaria / Q000150:complications / Q000188:drug therapy; D030821:Plants, Genetically Modified
chemical_list: D000962:Antimalarials
keywords: Developing countries; HIV; Malaria; Plant biotechnology; Poverty diseases