title: Prolonged consumption of trans fat favors the development of orofacial dyskinesia and anxiety-like symptoms in older rats.
abstract: Polyunsaturated fatty acids (FAs) are cell membrane components involved in brain functions. We hypothesized that long-term trans fat consumption is able to modify the membrane FAs composition impairing behavioral parameters related to aging. In this study, a comparison of behavioral parameters at 10 and 15 months of trans fat consumption by male Wistar rats was made. Animals were fed for 10 and 15 months from weaning with diets containing either 20% w/w soybean oil (SO), rich in n-6 PUFA, hydrogenated vegetable fat (HVF), rich in trans FAs, or a standard diet (control - C). At both evaluation times, HVF-fed rats showed progressively increased parameters of orofacial dyskinesia, fear and anxiety-like symptoms. The HVF diet reduced locomotor and exploratory activities progressively over 10 and 15 months of supplementation, while the standard and SO diets did not. In this study, we showed that chronic trans FAs consumption from weaning is able to favor the development of neuromotor and neuropsychiatric diseases, whose intensity was time dependent.
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria-UFSM-RS, Centro de Ciências da Saúde , Santa Maria, RS , Brazil .
authors.forename: Camila Simonetti
authors.initials: CS
authors.lastname: Pase
authors.forename: Angélica Martelli
authors.initials: AM
authors.lastname: Teixeira
authors.forename: Verônica Tironi
authors.initials: VT
authors.lastname: Dias
authors.forename: Andréia
authors.initials: A
authors.lastname: Quatrin
authors.forename: Tatiana
authors.initials: T
authors.lastname: Emanuelli
authors.forename: Marilise Escobar
authors.initials: ME
authors.lastname: Bürger
mesh_terms: D000375:Aging; D000818:Animals; D001007:Anxiety / Q000209:etiology*; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004032:Diet; D004041:Dietary Fats / Q000009:adverse effects* / Q000378:metabolism; D019587:Dietary Supplements; D005106:Exploratory Behavior / Q000187:drug effects; D043371:Fatty Acids, Omega-6 / Q000494:pharmacology; D005239:Fear; D006865:Hydrogenation; D008124:Locomotion / Q000187:drug effects; D008297:Male; D009069:Movement Disorders / Q000209:etiology*; D017208:Rats, Wistar; D013024:Soybean Oil / Q000494:pharmacology; D044242:Trans Fatty Acids / Q000009:adverse effects*
chemical_list: D004041:Dietary Fats; D043371:Fatty Acids, Omega-6; D044242:Trans Fatty Acids; D013024:Soybean Oil
keywords: Anxiety; locomotor activity; orofacial dyskinesia; polyunsaturated fatty acids; trans fatty acids