title: Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7.
abstract: By using the 10BASEd-T, we have synthesized a crown ether-like macrocyclic library possessing randomized peptide linkers on bacteriophage T7. Among 1.5 × 10(9) diversities of the supramolecule candidates, we have obtained a specific binder for the N-terminal domain of Hsp90.
authors.affiliation: Department of Engineering Science, Bioscience and Technology Program, The Graduate School of Informatics and Engineering, The University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan. taki@pc.uec.ac.jp.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Fukunaga
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hatanaka
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ito
authors.forename: Michiko
authors.initials: M
authors.lastname: Minami
authors.forename: Masumi
authors.initials: M
authors.lastname: Taki
mesh_terms: D017123:Bacteriophage T7 / Q000235:genetics*; D043844:Crown Ethers / Q000138:chemical synthesis* / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000235:genetics*
chemical_list: D043844:Crown Ethers; D046911:Macromolecular Substances; D010455:Peptides