title: Phototoxic reaction associated with Malarone (atovaquone/proguanil) antimalarial prophylaxis.
abstract: Phototoxic reaction has not been reported previously as an adverse reaction to the combination of atovaquone and proguanil (AP) (Malarone) used for antimalarial prophylaxis and therapy. We report here a 32-year-old patient treated with AP who presented with clinical manifestations of photosensitivity. AP-induced phototoxicity in this patient was further supported by phototesting. Malarone is not known to photosensitize and render the skin more susceptible to severe sunburn-like reactions. That it may do so, as in this case, is of importance especially as this drug is used predominantly by those travelling to sunnier climes. A notification of potential phototoxic effects of AP should be published for the choice of prophylaxis made by tourists traveling in malarial areas.
authors.affiliation: Department of Photodermatology, St Louis Hospital, University of Paris Descartes, Paris, France.
authors.forename: Aymeric
authors.initials: A
authors.lastname: Amelot
authors.forename: Jean
authors.initials: J
authors.lastname: Dupouy-Camet
authors.forename: Michel
authors.initials: M
authors.lastname: Jeanmougin
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000009:adverse effects*; D053626:Atovaquone / Q000009:adverse effects*; D017484:Dermatitis, Phototoxic / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D004338:Drug Combinations; D006801:Humans; D008288:Malaria / Q000517:prevention & control; D008297:Male; D002727:Proguanil / Q000009:adverse effects*; D014195:Travel
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; C109496:atovaquone, proguanil drug combination; D002727:Proguanil; D053626:Atovaquone
keywords: Malarone; antimalarial prophylaxis; phototoxic reaction; ultraviolet