title: Obesity with no metabolic syndrome and adipose tissue expansion based solely on risk factors and inflammatory marker of coronary heart disease in premenopausal women.
abstract: The objective of this study was to analyze whether obese women with no metabolic syndrome (MetS) have increased cardiometabolic risk compared to non-obese women and to observe the correlations between adiposity and coronary heart disease (CHD) risk factors in metabolically healthy women. 20-40 year old non-obese (n=41), obese with no MetS (n=30) and obese with MetS (n=28) women were studied. Lipid profile, blood pressure, CHD family history, physical inactivity, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, interleukin-1beta and tumor necrosis factor-alpha were analyzed. A subset of obese (13) and non-obese (33) women with no major components of MetS (except waist circumference) were further compared. Obese women with no MetS and non-obese women presented a similar metabolic profile that was statistically different from those seen in obese women with MetS. The number of obese women with no MetS and non-obese women presenting two or more risk factors (23.3 and 19.5%, respectively) or presenting high Framingham Risk Score (6.7 and 2.4%, respectively) were also similar. The only pro inflammatory protein correlated to waist circumference was hs-CRP. These data suggest that obesity with no MetS induce a CHD risk comparable to the risk seen in non-obese women. However, when women with no major components of MetS alone were considered, adiposity was positively correlated to blood pressure and hs-CRP. Although CHD risk of obese women with no MetS is closer to non-obese women, adipose tissue expansion was positively correlated to blood pressure and hs-CRP that are important risk factors for CHD.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Alves Ramos
authors.forename: Adriano de Paula
authors.initials: Ade P
authors.lastname: Sabino
authors.forename: Daniela
authors.initials: D
authors.lastname: Corrêa Ferreira
authors.forename: Jacqueline Isaura
authors.initials: JI
authors.lastname: Alvarez-Leite
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D003327:Coronary Disease / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis; D024821:Metabolic Syndrome / Q000150:complications; D009765:Obesity / Q000150:complications*; D010865:Pilot Projects; D012307:Risk Factors; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein