title: Molecularly imprinted polymers: compromise between flexibility and rigidity for improving capture of template analogues.
abstract: New synthetic strategies for molecularly imprinted polymers (MIPs) were developed to mimic the flexibility and mobility exhibited by receptor/enzyme binding pockets. The MIPs were prepared by bulk polymerization with quercetin as template molecule, acrylamide as functional monomer, ethylene glycol dimethacrylate as cross-linker, and THF as porogen. The innovative grafting of specific oligoethylene glycol units onto the imprinted cavities allowed MIPs to be obtained that exhibit extended selectivity towards template analogues. This synthetic strategy gives promising perspectives for the design of molecular recognition of molecules based on a congruent pharmacophore, which should be of interest for drug development.
authors.affiliation: Laboratory of Therapeutic Chemistry and Pharmacognosy, Research Institute for Health Sciences and Technology, University of Mons - UMONS, Place du Parc 20, 7000 Mons (Belgium), Fax: (+32) 065373426; Center of Innovation and Research in Materials and Polymers (CIRMAP), Laboratory of Polymeric and Composite Materials, University of Mons - UMONS, Place du Parc 20, 7000 Mons (Belgium); Laboratory of Pharmaceutical Analysis, University of Mons - UMONS, Place du Parc 20, 7000 Mons (Belgium). Antonelle.Pardo@umons.ac.be.
authors.forename: Antonelle
authors.initials: A
authors.lastname: Pardo
authors.forename: Laetitia
authors.initials: L
authors.lastname: Mespouille
authors.forename: Philippe
authors.initials: P
authors.lastname: Dubois
authors.forename: Bertrand
authors.initials: B
authors.lastname: Blankert
authors.forename: Pierre
authors.initials: P
authors.lastname: Duez
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D015195:Drug Design; D054802:Molecular Imprinting; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*
chemical_list: D000178:Acrylamides; D011108:Polymers
keywords: imprinting; liquid chromatography; molecular recognition; polymers