title: Saturated fatty acid intake can influence increase in plasminogen activator inhibitor-1 in obese adolescents.
abstract: The aim of this study was to verify if saturated fatty acid intake adjusted by tertiles can influence metabolic, inflammation, and plasminogen activator inhibitor-1 (PAI-1) in obese adolescents. Body mass, height, body mass index, waist circumference, blood pressure, and body composition of 108 obese adolescents were obtained. Fasting glucose, insulin, PAI-1, and CRP were determined. Insulin resistance was assessed by Homeostasis Model Assessment (HOMA-IR) and insulin sensitivity by Quantitative Insulin Sensitivity Check Index (QUICKI). Dietetic intake was estimated by a 3-day dietary record, and volunteers were divided according to consumption of saturated fatty acids: tertile 1 [Low Saturated Fatty Acid Intake (Low-SFA): ≤12.14 g], tertile 2 [Moderate Saturated Fatty Intake (Moderate SFA intake): 12.15-20.48 g], and tertile 3 [High Saturated Fatty Acid Intake (High-SFA Intake); >20.48 g]. Statistical analysis was performed using STATISTICA 7.0 software and the significance level was set at p<0.05. The most important finding in the present study is that Moderate and High-SFA intakes presented significantly higher values of PAI-1 than Low-SFA Intake. PAI-1 was positively associated with saturated fatty intake, waist circumference, mean blood pressure, and HOMA-IR. SFA intake was predictor of PAI-1 independent of body fat, HOMA-IR and total-cholesterol. In addition, PAI-1 was an independent predictor of blood pressure. HOMA-IR and QUICKI presented significantly higher and lower, respectively, in High-SFA compared to Moderate-SFA intake. High-SFA influenced cardiovascular disease risks, since it increased PAI-1 and insulin resistance, and decreased insulin sensibility, leading to vicious cycle among food ingestion, pro-thrombotic state, and cardiovascular risks in obese adolescents.
authors.affiliation: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo-SP, Brazil.
authors.forename: D C L
authors.initials: DC
authors.lastname: Masquio
authors.affiliation: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo-SP, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: de Piano
authors.affiliation: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo-SP, Brazil.
authors.forename: R M S
authors.initials: RM
authors.lastname: Campos
authors.affiliation: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo-SP, Brazil.
authors.forename: P L
authors.initials: PL
authors.lastname: Sanches
authors.affiliation: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo-SP, Brazil.
authors.forename: F C
authors.initials: FC
authors.lastname: Corgosinho
authors.affiliation: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo-SP, Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Carnier
authors.affiliation: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo-SP, Brazil.
authors.forename: L M
authors.initials: LM
authors.lastname: Oyama
authors.affiliation: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo-SP, Brazil.
authors.forename: C M P O
authors.initials: CM
authors.lastname: do Nascimento
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo-SP, Brazil.
authors.forename: M T
authors.initials: MT
authors.lastname: de Mello
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo-SP, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Tufik
authors.affiliation: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo-SP, Brazil.
authors.forename: A R
authors.initials: AR
authors.lastname: Dâmaso
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000378:metabolism*; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D012044:Regression Analysis; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D017395:Plasminogen Activator Inhibitor 1; D002097:C-Reactive Protein