title: [Morphofunctional state of vessel endothelium at the early stage of cerebral ischemia-reperfusion and the effect of taurin administration].
abstract: Experiments in a group of 28 male rats with ischemic-reperfusive brain damage showed (i) the presence of endothelial dysfunction manifested by an increase in the number of circulating endothelial cells and a decrease in the activity of alkaline phosphatase, (ii) activation of the platelet and coagulation hemostasis, (iii) modification of the frontal brain cortex. The administration of taurin led to correction of the endothelial dysfunction, removal of morphological changes in the brain cortex, and improvement in the aggregation of platelets and blood coagulation.
authors.forename: T A
authors.initials: TA
authors.lastname: Rukan
authors.forename: N E
authors.initials: NE
authors.lastname: Mksimovich
authors.forename: S M
authors.initials: SM
authors.lastname: Zimatkin
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D042783:Endothelial Cells / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D015427:Reperfusion Injury / Q000378:metabolism* / Q000473:pathology; D013654:Taurine / Q000494:pharmacology*
chemical_list: D013654:Taurine