title: Extreme hyperleukocytosis in a pediatric T-ALL patient with a rare translocation, t(7;19)(q35;p13), and submicroscopic deletions at 4q25, 7q33 and 10q23.
abstract: Although childhood T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk disease the outcome can vary considerably. The varying outcomes suggest that unrecognized factors may contribute to disease progression. We report on a 2-year-old T-ALL patient presenting with a very short history of constipation and extreme hyperleukocytosis (WBC 882×10(9)/L). In her leukemic cells we detected the very rare translocation t(7;19)(q35;p13) and LYL1 overexpression. Additionally, we detected submicroscopic deletions at 4q25, 7q33 and 10q23 by oligo-aCGH analysis. We suggest that LYL1 overexpression contributed to the leukemic state and propose that the observed microdeletions may have influenced to the rapid disease progression.
authors.affiliation: Hemodiagnostic Laboratory, Department of Hematology, Aarhus University Hospital, Tage-Hansens Gade 2, Ent. 4A, 8000 Aarhus C, Denmark.
authors.forename: Christopher
authors.initials: C
authors.lastname: Veigaard
authors.affiliation: Hemodiagnostic Laboratory, Department of Hematology, Aarhus University Hospital, Tage-Hansens Gade 2, Ent. 4A, 8000 Aarhus C, Denmark.
authors.forename: Anni
authors.initials: A
authors.lastname: Aggerholm
authors.affiliation: Department of Pediatrics, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Hasle
authors.affiliation: Hemodiagnostic Laboratory, Department of Hematology, Aarhus University Hospital, Tage-Hansens Gade 2, Ent. 4A, 8000 Aarhus C, Denmark.
authors.forename: Eigil
authors.initials: E
authors.lastname: Kjeldsen
keywords: Acute T-lymphoblastic leukemia; Hyperleukocytosis; LYL1; aCGH analysis; t(7;19)