title: Goseki grade and tumour location influence survival of patients with gastric cancer.
abstract: BACKGROUND
  Owing to the variability of histopathological features and biological behaviour in gastric carcinoma, a great number of categorisation methods such as classical histopathologic grading, Lauren classification, the TNM staging system and the newly presented Goseki grading method are used by pathologists and other scientists. In our study, we aimed to investigate whether Goseki grade and tumour location have an effects on survival of gastric cancer cases.
  
  
  METHODS
  Eighty-four patients with gastric adenocarcinoma were covered in the investigation. The importance of Goseki grading system and tumour location were analysed in addition to the TNM staging and other conventional prognostic parameters.
  
  
  RESULTS
  The median survival time in our patients was 35 months (minimum: 5, maximum: 116). According to our findings, there was no relation between survival and tumour size (p=0.192) or classical histological type (p=0.270). In contrast, the Goseki grade and tumour location significantly correlated with survival (p=0.007 and p<0.001, respectively). Additionally, tumours of the intestinal type had a longer median survival time (60.0 months) than diffuse tumours (24.0 months).
  
  
  CONCLUSIONS
  In addition to the TNM staging system, tumour location and the Goseki grading system may be used as significant prognostic parameters in patients with gastric cancer.
authors.affiliation: Department of Pathology, Faculty of Medicine, Ataturk University, Erzurum, Turkey E-mail : muhammet.calik@atauni.edu.tr.
authors.forename: Muhammet
authors.initials: M
authors.lastname: Calik
authors.forename: Ilknur
authors.initials: I
authors.lastname: Calik
authors.forename: Elif
authors.initials: E
authors.lastname: Demirci
authors.forename: Eren
authors.initials: E
authors.lastname: Altun
authors.forename: Betul
authors.initials: B
authors.lastname: Gundogdu
authors.forename: Sare
authors.initials: S
authors.lastname: Sipal
authors.forename: Cemal
authors.initials: C
authors.lastname: Gundogdu
mesh_terms: D000230:Adenocarcinoma / Q000145:classification* / Q000401:mortality* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000145:classification* / Q000401:mortality* / Q000473:pathology; D015996:Survival Rate; D016896:Treatment Outcome; D014421:Turkey