title: Virtual Screening of Indonesian Herbal Database as HIV-1 Protease Inhibitor.
abstract: HIV-1 (Human immunodeficiency virus type 1)׳s infection is considered as one of most harmful disease known by human, the survivability rate of the host reduced significantly when it developed into AIDS. HIV drug resistance is one of the main problems of its treatment and several drug designs have been done to find new leads compound as the cure. In this study, in silico virtual screening approach was used to find lead molecules from the library or database of natural compounds as HIV-1 protease inhibitor. Virtual screening against Indonesian Herbal Database with AutoDock was performed on HIV-1 protease. From the virtual screening, top ten compounds obtained were 8-Hydroxyapigenin 8-(2",4"-disulfatoglucuronide), Isoscutellarein 4'-methyl ether, Amaranthin, Torvanol A, Ursonic acid, 5-Carboxypyranocyanidin 3-O-(6"-O-malonyl-beta-glucopyranoside), Oleoside, Jacoumaric acid, Platanic acid and 5-Carboxypyranocyanidin 3-O-beta-glucopyranoside.
authors.affiliation: Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.
authors.forename: Arry
authors.initials: A
authors.lastname: Yanuar
authors.affiliation: Faculty of Computer Sciences, Universitas Indonesia, Depok 16424, Indonesia.
authors.forename: Heru
authors.initials: H
authors.lastname: Suhartanto
authors.affiliation: Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.
authors.forename: Abdul
authors.initials: A
authors.lastname: Munim
authors.affiliation: Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.
authors.forename: Bram Hik
authors.initials: BH
authors.lastname: Anugraha
authors.affiliation: Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.
authors.forename: Rezi Riadhi
authors.initials: RR
authors.lastname: Syahdi
keywords: HIV-1 protease; Indonesian herbal database; molecular docking; virtual screening