title: HIV/AIDS-related visceral leishmaniasis: a clinical and epidemiological description of visceral leishmaniasis in northern Brazil.
abstract: BACKGROUND
  This study aimed to describe the main features of visceral leishmaniasis (VL), both related to and independent of human immunodeficiency virus (HIV) infection, in patients who were registered in Tocantins, Brazil.
  
  
  METHODS
  Data from 1,779 new patients with VL, 33 of whom were also infected with HIV, were reviewed.
  
  
  RESULTS
  The incidence of VL/HIV coinfection increased from 0.32/100,000 inhabitants in 2007 to 1.08/100,000 inhabitants in 2010. VL occurred predominantly in children aged 10 years or younger, while VL/HIV was more common in patients aged between 18 and 50 years. There were more male patients in the VL/HIV group than in the VL group. Relapse rates were also considerably higher in the VL/HIV (9.1%) group than in the VL group (1.5%). Despite a similar clinical presentation, VL/HIV patients exhibited a higher proportion (24.2%) of concomitant infectious diseases and jaundice. Pentavalent antimonials were used for the initial treatment of VL and VL/HIV infections. However, amphotericin B deoxycholate and liposomal amphotericin B were also widely used in the treatment of VL/HIV coinfection. The mortality rate was higher in the VL/HIV coinfection group (19.4%) than in the VL group (5.4%). Furthermore, the mortality rate due to other causes was significantly higher in the VL/HIV group (12.9%) than in the VL group (0.7%).
  
  
  CONCLUSIONS
  The study showed that the incidence, clinical characteristics and outcomes among the VL and VL/HIV patients in this state are similar to those from other endemic regions, indicating that both infections are emerging with increasing frequency in Brazil.
authors.affiliation: Universidade Federal do Tocantins, PalmasTO, Curso de Medicina, Universidade Federal do Tocantins, Palmas, TO.
authors.forename: Leonardo Cordenonzi Pedroso de
authors.initials: LC
authors.lastname: Albuquerque
authors.affiliation: Universidade Federal do Tocantins, PalmasTO, Curso de Medicina, Universidade Federal do Tocantins, Palmas, TO.
authors.forename: Iatan Rezende
authors.initials: IR
authors.lastname: Mendonça
authors.affiliation: Universidade Federal do Tocantins, PalmasTO, Curso de Medicina, Universidade Federal do Tocantins, Palmas, TO.
authors.forename: Polyana Nascimento
authors.initials: PN
authors.lastname: Cardoso
authors.affiliation: Universidade Federal do Tocantins, PalmasTO, Curso de Medicina, Universidade Federal do Tocantins, Palmas, TO.
authors.forename: Leonardo Rodrigo
authors.initials: LR
authors.lastname: Baldaçara
authors.affiliation: Universidade Federal do Tocantins, PalmasTO, Curso de Medicina, Universidade Federal do Tocantins, Palmas, TO.
authors.forename: Myrlena Regina Machado Mescouto
authors.initials: MR
authors.lastname: Borges
authors.affiliation: Universidade Federal do Tocantins, PalmasTO, Curso de Medicina, Universidade Federal do Tocantins, Palmas, TO.
authors.forename: Joelma da Costa
authors.initials: Jda C
authors.lastname: Borges
authors.affiliation: Universidade Federal do Tocantins, PalmasTO, Curso de Medicina, Universidade Federal do Tocantins, Palmas, TO.
authors.forename: Maria Cristina da Silva
authors.initials: MC
authors.lastname: Pranchevicius
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004522:Educational Status; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D055815:Young Adult