title: Role of calcium signaling in epithelial bicarbonate secretion.
abstract: Transepithelial bicarbonate secretion plays a key role in the maintenance of fluid and protein secretion from epithelial cells and the protection of the epithelial cell surface from various pathogens. Epithelial bicarbonate secretion is mainly under the control of cAMP and calcium signaling. While the physiological roles and molecular mechanisms of cAMP-induced bicarbonate secretion are relatively well defined, those induced by calcium signaling remain poorly understood in most epithelia. The present review summarizes the current status of knowledge on the role of calcium signaling in epithelial bicarbonate secretion. Specifically, this review introduces how cytosolic calcium signaling can increase bicarbonate secretion by regulating membrane transport proteins and how it synergizes with cAMP-induced mechanisms in epithelial cells. In addition, tissue-specific variations in the pancreas, salivary glands, intestines, bile ducts, and airways are discussed. We hope that the present report will stimulate further research into this important topic. These studies will provide the basis for future medicines for a wide spectrum of epithelial disorders including cystic fibrosis, Sjögren's syndrome, and chronic pancreatitis.
authors.affiliation: Department of Pharmacology and Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea; Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea.
authors.forename: Jinsei
authors.initials: J
authors.lastname: Jung
authors.affiliation: Department of Pharmacology and Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea. Electronic address: mlee@yuhs.ac.
authors.forename: Min Goo
authors.initials: MG
authors.lastname: Lee
mesh_terms: D001639:Bicarbonates / Q000378:metabolism*; D001652:Bile Ducts / Q000378:metabolism; D020013:Calcium Signaling; D000242:Cyclic AMP / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D012137:Respiratory System / Q000378:metabolism; D012469:Salivary Glands / Q000378:metabolism
chemical_list: D001639:Bicarbonates; D026901:Membrane Transport Proteins; D000242:Cyclic AMP
keywords: Bicarbonate; Calcium signaling; Epithelial cell; Fluid secretion