title: Long-term trends in incidence and mortality of intrahepatic and extrahepatic bile duct cancer in Japan.
abstract: BACKGROUND
  A report of multiple cases of bile duct cancer at a Japanese printing company raised concern about such cancers. We examined long-term trends in bile duct cancer in Japan.
  
  
  METHODS
  Data from 4 population-based cancer registries were used to calculate incidence between 1985 and 2007, and vital statistics were used to estimate mortality between 1985 and 2011. Age-standardized rates were calculated and analyzed using a joinpoint regression model.
  
  
  RESULTS
  Among men, the incidence rate of intrahepatic bile duct cancer increased throughout the observation period; among women, it increased until 1996-1998 and remained stable thereafter. The incidence rate of extrahepatic bile duct cancer was stable in men and decreased from 1993-1995 in women. In people aged 30 to 49 years, the incidence rates of intra- and extrahepatic bile duct cancer remained stable or decreased. The mortality rate of intrahepatic bile duct cancer increased in both sexes and in all age groups since 1996, while that of extrahepatic bile duct cancer decreased since 1992. In people aged 30 to 49 years, the mortality rates of intra- and extrahepatic bile duct cancer remained stable and decreased, respectively.
  
  
  CONCLUSIONS
  The incidence and mortality rates of intrahepatic bile duct cancer remained stable or increased throughout the observation period. The incidence rate of extrahepatic bile duct cancer remained stable or decreased, and the mortality rate decreased since 1992. In people aged 30 to 49 years, the incidence and mortality rates of intra- and extrahepatic bile cancer remained stable or decreased.
authors.affiliation: Department of Mathematical Health Science, Graduate School of Medicine, Osaka University.
authors.forename: Mai
authors.initials: M
authors.lastname: Utada
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ohno
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tamaki
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Sobue
authors.forename: Ginji
authors.initials: G
authors.lastname: Endo
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000453:epidemiology* / Q000401:mortality; D017734:Bile Ducts, Extrahepatic; D001653:Bile Ducts, Intrahepatic; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends*; D012042:Registries; D017678:Sex Distribution; D055815:Young Adult