title: A case of pulmonary mucoepidermoid carcinoma responding to carboplatin and paclitaxel.
abstract: A 59-year-old man was admitted to our hospital with dyspnea and cough. A large polypoid tumor was observed in the lower trachea and bronchoscopic polypectomy was performed using a snare to relieve symptoms. The tumor was diagnosed as a high grade mucoepidermoid carcinoma mainly by the histology of piecemeal specimens obtained by bronchoscopic resection. The primary lesion involved the trachea and the main bronchus, and there were multiple metastases in the lung. The patient was treated with the combination of carboplatin and paclitaxel. After four cycles of chemotherapy, the tumors were significantly reduced. He remains well without evidence of tumor progression for 25 months. This case suggests that the combination chemotherapy of carboplatin and paclitaxel can be an option for treatment of pulmonary mucoepidermoid carcinoma.
authors.affiliation: * Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nakasone-cho, Kita-ku, Sakai City, Osaka, 591-8555 Japan. t-kawaguchi@kch.hosp.go.jp.
authors.forename: Shoko
authors.initials: S
authors.lastname: Sonobe
authors.forename: Koji
authors.initials: K
authors.lastname: Inoue
authors.forename: Sayaka
authors.initials: S
authors.lastname: Tachibana
authors.forename: Masaaki
authors.initials: M
authors.lastname: Shiojiri
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Maeda
authors.forename: Norihiko
authors.initials: N
authors.lastname: Nakanishi
authors.forename: Tomonori
authors.initials: T
authors.lastname: Moritaka
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ikura
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kawaguchi
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001984:Bronchial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016190:Carboplatin / Q000008:administration & dosage; D018277:Carcinoma, Mucoepidermoid / Q000188:drug therapy* / Q000556:secondary; D018572:Disease-Free Survival; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D014134:Tracheal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin; D017239:Paclitaxel
keywords: carboplatin and paclitaxel; high grade; polypectomy; pulmonary mucoepidermoid carcinoma