title: The aryl hydrocarbon receptor-activating effect of uremic toxins from tryptophan metabolism: a new concept to understand cardiovascular complications of chronic kidney disease.
abstract: Patients with chronic kidney disease (CKD) have a higher risk of cardiovascular diseases and suffer from accelerated atherosclerosis. CKD patients are permanently exposed to uremic toxins, making them good candidates as pathogenic agents. We focus here on uremic toxins from tryptophan metabolism because of their potential involvement in cardiovascular toxicity: indolic uremic toxins (indoxyl sulfate, indole-3 acetic acid, and indoxyl-β-d-glucuronide) and uremic toxins from the kynurenine pathway (kynurenine, kynurenic acid, anthranilic acid, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid). Uremic toxins derived from tryptophan are endogenous ligands of the transcription factor aryl hydrocarbon receptor (AhR). AhR, also known as the dioxin receptor, interacts with various regulatory and signaling proteins, including protein kinases and phosphatases, and Nuclear Factor-Kappa-B. AhR activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and some polychlorinated biphenyls is associated with an increase in cardiovascular disease in humans and in mice. In addition, this AhR activation mediates cardiotoxicity, vascular inflammation, and a procoagulant and prooxidant phenotype of vascular cells. Uremic toxins derived from tryptophan have prooxidant, proinflammatory, procoagulant, and pro-apoptotic effects on cells involved in the cardiovascular system, and some of them are related with cardiovascular complications in CKD. We discuss here how the cardiovascular effects of these uremic toxins could be mediated by AhR activation, in a "dioxin-like" effect.
authors.affiliation: Aix Marseille Université, Inserm, VRCM, UMR_S 1076, Marseille13005, France. marionsallee@yahoo.fr.
authors.forename: Marion
authors.initials: M
authors.lastname: Sallée
authors.affiliation: Aix Marseille Université, Inserm, VRCM, UMR_S 1076, Marseille13005, France. laetitia.dou@univ-amu.fr.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Dou
authors.affiliation: Aix Marseille Université, Inserm, VRCM, UMR_S 1076, Marseille13005, France. claire.cerini@univ-amu.fr.
authors.forename: Claire
authors.initials: C
authors.lastname: Cerini
authors.affiliation: Aix Marseille Université, Inserm, VRCM, UMR_S 1076, Marseille13005, France. stephane.poitevin@univ-amu.fr.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Poitevin
authors.affiliation: Aix Marseille Université, Inserm, VRCM, UMR_S 1076, Marseille13005, France. drphilippe.brunet@outlook.com.
authors.forename: Philippe
authors.initials: P
authors.lastname: Brunet
authors.affiliation: Aix Marseille Université, Inserm, VRCM, UMR_S 1076, Marseille13005, France. stephane.burtey@ap-hm.fr.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Burtey
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D018384:Oxidative Stress; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism*; D014118:Toxins, Biological / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*; D014511:Uremia / Q000378:metabolism*
chemical_list: D018336:Receptors, Aryl Hydrocarbon; D014118:Toxins, Biological; D014364:Tryptophan