title: Mutual induced fit in a synthetic host-guest system.
abstract: Mutual induced fit is an important phenomenon in biological molecular recognition, but it is still rare in artificial systems. Here we report an artificial host-guest system in which a flexible calix[4]arene is enclathrated in a dynamic self-assembled host and both molecules mutually adopt specific three-dimensional structures. NMR data revealed the conformational changes, and crystallographic studies clearly established the precise structures at each stage.
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Sawada
authors.forename: Hayato
authors.initials: H
authors.lastname: Hisada
authors.forename: Makoto
authors.initials: M
authors.lastname: Fujita
mesh_terms: D047250:Calixarenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D047250:Calixarenes