title: NIS-assisted aza-Friedel-Crafts reaction with α-carbamoysulfides as precursors of N-carbamoylimines.
abstract: A general and practical N-iodosuccinimide (NIS)-promoted aza-Friedel-Crafts reaction of various aromatic nucleophiles with N-acylimines generated in situ from α-amidosulfides to give a rapid access to highly functionalized amines is described. The newly developed methodology is very mild, fast, efficient, and complementary.
authors.affiliation: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex (France), Fax: (+33) 1-69077247.
authors.forename: Nicolas
authors.initials: N
authors.lastname: George
authors.forename: Mathieu
authors.initials: M
authors.lastname: Bekkaye
authors.forename: Aurélien
authors.initials: A
authors.lastname: Alix
authors.forename: Jieping
authors.initials: J
authors.lastname: Zhu
authors.forename: Géraldine
authors.initials: G
authors.lastname: Masson
keywords: Friedel-Crafts reaction; N-iodosuccinimide; imines; multicomponent reactions; tandem reactions