title: NF-κB in cellular senescence and cancer treatment.
abstract: The NF-κB pathway transcriptionally controls a large set of target genes that play important roles in cell survival, inflammation, and immune responses. While many studies showed anti-tumorigenic and pro-survival role of NF-κB in cancer cells, recent findings postulate that NF-κB participates in a senescence-associated cytokine response, thereby suggesting a tumor restraining role of NF-κB. In this review, we discuss implications of the NF-κB signaling pathway in cancer. Particularly, we emphasize the connection of NF-κB with cellular senescence as a response to chemotherapy, and furthermore, present examples how distinct oncogenic network contexts surrounding NF-κB produce fundamentally different treatment outcomes in aggressive B-cell lymphomas as an example.
authors.affiliation: MKFZ, Charité - Universitätsmedizin Berlin and Max-Delbrück-Centrum for Molecular Medicine, Berlin, Germany.
authors.forename: Hua
authors.initials: H
authors.lastname: Jing
authors.forename: Soyoung
authors.initials: S
authors.lastname: Lee
mesh_terms: D000818:Animals; D017209:Apoptosis; D016922:Cellular Senescence; D006801:Humans; D058990:Molecular Targeted Therapy; D016328:NF-kappa B / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D009857:Oncogenes; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D016328:NF-kappa B