title: Surfactant-induced chronic pruritus: Role of L-histidine decarboxylase expression and histamine production in epidermis.
abstract: Shampoo and cleansers containing anionic surfactants including sodium dodecyl sulphate (SDS) often cause pruritus in humans. Daily application of 1-10% SDS for 4 days induced hind-paw scratching (an itch-related behaviour) in a concentration-dependent manner, and 10% SDS also caused dermatitis, skin dryness, barrier disruption, and an increase in skin surface pH in mice. SDS-induced scratching was inhibited by the opioid receptor antagonist naloxone and the H histamine receptor antagonist terfenadine. Mast-cell deficiency did not inhibit SDS-induced scratching, although it almost completely depleted histamine in the dermis. Treatment with SDS increased the histamine content of the epidermis, but not that of the dermis. SDS treatment increased the gene expression and post-translation processing of L-histidine decarboxylase in the epidermis. The present results suggest that repeated application of SDS induces itch through increased production of epidermal histamine, which results from an increase in the gene expression and post-translation processing of L-histidine decarboxylase.
authors.affiliation: Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Inami
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sasaki
authors.forename: Tsugunobu
authors.initials: T
authors.lastname: Andoh
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kuraishi
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004195:Disease Models, Animal; D004790:Enzyme Induction; D004817:Epidermis / Q000201:enzymology*; D006632:Histamine / Q000378:metabolism*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006640:Histidine Decarboxylase / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008407:Mast Cells / Q000201:enzymology*; D008813:Mice, Inbred ICR; D009292:Narcotic Antagonists / Q000494:pharmacology; D011499:Protein Processing, Post-Translational; D011537:Pruritus / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics / Q000517:prevention & control / Q000523:psychology; D012521:Sarcosine / Q000031:analogs & derivatives*; D015398:Signal Transduction; D012967:Sodium Dodecyl Sulfate; D013501:Surface-Active Agents; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D006634:Histamine H1 Antagonists; D009292:Narcotic Antagonists; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; C025231:sarkosyl; D006632:Histamine; D006640:Histidine Decarboxylase; D012521:Sarcosine