title: Aurora-A V57I (rs1047972) polymorphism and cancer susceptibility: a meta-analysis involving 27,269 subjects.
abstract: BACKGROUND
  The association between Aurora-A V57I (rs1047972, G>A) polymorphism and cancer susceptibility has been widely studied. However, the results are inconsistent.
  
  
  RESULTS
  To obtain a more precise evaluation of the relationship, we performed a meta-analysis of 14 case-control studies involving a total of 11,245 cancer cases and 16,024 controls. Our results demonstrated that there was a borderline evidence of an association between the Aurora-A V57I polymorphism and the decreased risk of overall cancer in two genetic models: AA vs. GA+GG and AA vs. GG. In a stratified analysis by cancer type, significant association between Aurora-A V57I polymorphism and the decreased risk of breast cancer was identified in one genetic model: AA vs. GG. In a stratified analysis by ethnicity, in three genetic models, significant decreased cancer risk was observed among Caucasians (AA vs. GA+GG; AA vs. GG and A vs. G) instead of Asians. Furthermore, a stratified analysis by ethnicity in breast cancer subgroup, five genetic models (AA+GA vs. GG; AA vs. GA+GG; AA vs. GG; AA vs. GA and A vs. G), significant decreased cancer risk was observed among Caucasians, but not among Asians. A slight publication bias was observed in our meta-analysis, thus nonparametric "trim-and-fill" method was utilized to detect the stability of our results. The adjusted odds ratios and confidence intervals showed that Aurora-A V57I polymorphism might be a protective factor for cancer risk, suggesting the reliability of our findings.
  
  
  CONCLUSIONS
  In summary, this meta-analysis suggests that Aurora-A V57I polymorphism may be a protective factor for cancer risk.
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu Province, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Qiu
authors.affiliation: Emergency Department, Affiliated Jintan People's Hospital of Jiangsu University, Jintan, Jiangsu Province, China.
authors.forename: Heping
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu Province, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.
authors.forename: Haiyong
authors.initials: H
authors.lastname: Gu
mesh_terms: D019943:Amino Acid Substitution; D064096:Aurora Kinase A / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors
chemical_list: C576917:AURKA protein, human; D064096:Aurora Kinase A