title: A dual-targeting upconversion nanoplatform for two-color fluorescence imaging-guided photodynamic therapy.
abstract: The targetability of a theranostic probe is one of the keys to assuring its theranostic efficiency. Here we show the design and fabrication of a dual-targeting upconversion nanoplatform for two-color fluorescence imaging-guided photodynamic therapy (PDT). The nanoplatform was prepared from 3-aminophenylboronic acid functionalized upconversion nanocrystals (APBA-UCNPs) and hyaluronated fullerene (HAC60) via a specific diol-borate condensation. The two specific ligands of aminophenylboronic acid and hyaluronic acid provide synergistic targeting effects, high targetability, and hence a dramatically elevated uptake of the nanoplatform by cancer cells. The high generation yield of (1)O2 due to multiplexed Förster resonance energy transfer between APBA-UCNPs (donor) and HAC60 (acceptor) allows effective therapy. The present nanoplatform shows great potential for highly selective tumor-targeted imaging-guided PDT.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology (Nankai University), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Research Center for Analytical Sciences, College of Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Cheng-Xiong
authors.initials: CX
authors.lastname: Yang
authors.forename: Jia-Tong
authors.initials: JT
authors.lastname: Chen
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Yan
mesh_terms: D000818:Animals; D003116:Color; D031541:Fluorescence Resonance Energy Transfer; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology; D016716:PC12 Cells; D010778:Photochemotherapy; D066244:Proton Magnetic Resonance Spectroscopy; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared