title: [Chronic myeloid leukemia in an adult with common variable immunodeficiency].
abstract: BACKGROUND
  Common variable immunodeficiency is a primary immunodeficiency, in which from 70 to 80 % of patients have tumors and 25 % of cases are associated with autoimmune diseases. Common variable immunodeficiency patients have a higher incidence of neoplasms, with a risk 12-18 times higher than the general population. There are few cases of common variable immunodeficiency patients with leukemia.
  
  
  METHODS
  Female of 36 years old, with left upper quadrant pain, early satiety, weight loss of 8 kg in three months and splenomegaly. The complete blood count showed: leukocytosis 206 000/mL, with 8 % blasts, platelets 530 000/mL and hemoglobin 8 mg/dL. Abdominal ultrasound: 19??12 cm splenomegaly. Karyotype BCR/ABL IS 64.20 %, 100 % Philadelphia chromosome. The diagnosis was of chronic myeloid leukemia. Given the presence of recurrent respiratory tract infection, frequent diarrheas and reduced concentrations of IgG, IgM and IgA, common variable immunodeficiency was diagnosed and human immunoglobulin was used successfully.
  
  
  CONCLUSIONS
  The association between chronic myeloid leukemia and common variable immunodefficiency is unusual. Given the high frequency of hematological neoplasm in common variable immunodeficiency patients, we suggest that hematological patients with repeated infections and decreased concentrations of immunoglobulin be referred to an immunological evaluation.
authors.affiliation: Servicio de Alergia e Inmunología Clínica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, México. patyfritzenwalden@hotmail.com.
authors.forename: Patricia María
authors.initials: PM
authors.lastname: O'Farrill-Romanillos
authors.forename: Lucy Vania
authors.initials: LV
authors.lastname: Galindo-Pacheco
authors.forename: Adela Sisy
authors.initials: AS
authors.lastname: Amaya-Mejía
authors.forename: Freya Helena
authors.initials: FH
authors.lastname: Campos-Romero
authors.forename: Laura Dafne
authors.initials: LD
authors.lastname: Mendoza-Reyna
authors.forename: Fernando
authors.initials: F
authors.lastname: Pérez-Rocha
authors.forename: Nora Hilda
authors.initials: NH
authors.lastname: Segura-Méndez
mesh_terms: D000328:Adult; D017074:Common Variable Immunodeficiency / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000209:etiology*
keywords: Chronic myelogenous leukemia; Common variable immunodefiency