title: Changes in low-frequency fluctuations in patients with antisocial personality disorder revealed by resting-state functional MRI.
abstract: Antisocial Personality Disorder (APD) is a personality disorder that is most commonly associated with the legal and criminal justice systems. The study of the brain in APD has important implications in legal contexts and in helping ensure social stability. However, the neural contribution to the high prevalence of APD is still unclear. In this study, we used resting-state functional magnetic resonance imaging (fMRI) to investigate the underlying neural mechanisms of APD. Thirty-two healthy individuals and thirty-five patients with APD were recruited. The amplitude of low-frequency fluctuations (ALFF) was analyzed for the whole brain of all subjects. Our results showed that APD patients had a significant reduction in the ALFF in the right orbitofrontal cortex, the left temporal pole, the right inferior temporal gyrus, and the left cerebellum posterior lobe compared to normal controls. We observed that the right orbitofrontal cortex had a negative correlation between ALFF values and MMPI psychopathic deviate scores. Alterations in ALFF in these specific brain regions suggest that APD patients may be associated with abnormal activities in the fronto-temporal network. We propose that our results may contribute in a clinical and forensic context to a better understanding of APD.
authors.affiliation: Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, P.R.China; Biomedical Engineering Laboratory, School of Geosciences and Info-Physics, Central South University, Changsha, Hunan, P.R.China.
authors.forename: Huasheng
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, P.R.China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liao
authors.affiliation: Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, P.R.China; Biomedical Engineering Laboratory, School of Geosciences and Info-Physics, Central South University, Changsha, Hunan, P.R.China; Department of Information Science and Engineering, Hunan First Normal University, Changsha, Hunan, P.R.China.
authors.forename: Weixiong
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, P.R.China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000987:Antisocial Personality Disorder / Q000503:physiopathology*; D001931:Brain Mapping; D058256:Brain Waves; D002531:Cerebellum / Q000503:physiopathology*; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D013702:Temporal Lobe / Q000503:physiopathology*; D055815:Young Adult