title: Metabolic syndrome and risk for ED: a meta-analysis.
abstract: There are many recent observational studies on metabolic syndrome (MS) and the risk for ED, and it is still inconclusive whether MS increases the risk for ED. This meta-analysis aims to detect a relationship between MS and ED. We identified eligible studies by searching PubMed, Embase and the Cochrane Library for articles published before August 2013. Adjusted relative risks (RR) with 95% confidence interval (CI) were calculated using random-effects or fixed-effects models. A total of 10 studies involving 4092 participants were included in the meta-analysis. MS was associated with an increased incidence of ED (RR=1.60, 95% CI=1.27-2.02, P<0.001), with significant evidence of heterogeneity among these studies (P for heterogeneity <0.001, I(2)=92.9%). The subgroup and sensitivity analyses confirmed the stability of the results and no publication bias was detected. The present meta-analysis suggests that MS is significantly associated with the risk for ED. Large-scale and well-designed prospective studies are required to further investigate the association between MS and risk for ED.
authors.affiliation: Department of Urology, Medical Center for Overseas Patients, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: L H
authors.initials: LH
authors.lastname: Liu
authors.affiliation: Department of Urology, Medical Center for Overseas Patients, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Y R
authors.initials: YR
authors.lastname: Zhang
authors.affiliation: Department of Thoracic and Cardiothoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: T S
authors.initials: TS
authors.lastname: Liu
authors.affiliation: Department of Urology, Medical Center for Overseas Patients, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: H B
authors.initials: HB
authors.lastname: Zhang
authors.affiliation: Department of Urology, Medical Center for Overseas Patients, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: F Z
authors.initials: FZ
authors.lastname: Chen
authors.affiliation: The Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: S H
authors.initials: SH
authors.lastname: He
authors.affiliation: Department of Urology, Medical Center for Overseas Patients, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: A Y
authors.initials: AY
authors.lastname: Wei
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D007172:Erectile Dysfunction / Q000453:epidemiology / Q000209:etiology*; D005006:Ethnicity / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D008875:Middle Aged