title: Lipodystrophy among patients with HIV infection on antiretroviral therapy: a systematic review protocol.
abstract: BACKGROUND
  Lipodystrophy is a frequent and disfiguring adverse effect of antiretroviral therapy (ART) in patients with HIV. It affects the quality of life of the patient and adherence to treatment, and generates new needs for comprehensive healthcare services. The aim of this study will be to conduct a systematic review of the literature from observational studies and describe lipodystrophy among patients with HIV infection during current or previous use of ART.
  
  
  METHODS
  A systematic review of observational studies published in MEDLINE, CINAHL, LILACS, EMBASE and International Pharmaceutical Abstracts will be carried out. Citations of included studies will be checked to identify additional studies not identified in the electronic searches. It will include any observational study that considered lipodystrophy as the primary or secondary outcome and that had enrolled adolescent and adult patients with HIV infection who were on current or previous ART for at least 6 months. Data extraction and analysis will be performed independently by two reviewers. The extracted data will be discussed, decisions documented and, where necessary, the authors of the studies will be contacted for clarification. Measures of frequency, prevalence and incidence of lipodystrophy will be stratified according to definition, method of diagnosis and risk factors of the outcome.
  
  
  BACKGROUND
  Ethics is not required given this is a protocol for a systematic review. The findings of this study will be widely disseminated through peer-reviewed publications and conference presentations. Updates of the review will be conducted to inform and guide healthcare practice.
  
  
  BACKGROUND
  PROSPERO-42013005450.
authors.affiliation: Departamento de Farmácia Social, Faculdade de Farmácia, Centro de Estudos do Medicamento (Cemed), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Lorena Gomes Cunha
authors.initials: LG
authors.lastname: Lana
authors.forename: Daniela Rezende Garcia
authors.initials: DR
authors.lastname: Junqueira
authors.forename: Edson
authors.initials: E
authors.lastname: Perini
authors.forename: Cristiane
authors.initials: C
authors.lastname: Menezes de Pádua
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008060:Lipodystrophy / Q000209:etiology*; D012107:Research Design; D000078202:Systematic Reviews as Topic
chemical_list: D019380:Anti-HIV Agents
keywords: HIV; adverse drug reaction; antiretroviral regimen; lipodystrophy; systematic review