title: Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches.
abstract: Mitochondrial biogenesis (MB) is the essential mechanism by which cells control the number of mitochondria. Cells respond to different physiologic, metabolic, and pathologic changes by regulating this organelle with high morphological and functional adaptability. A considerable number of proteins, transcription factors, upstream regulatory proteins and secondary mechanisms are involved in MB and the stabilization of new mitochondrial DNA. These MB activators and regulators, including the main participating proteins (e.g. PGC-1α and mtTFA), are candidates for therapeutic intervention in diverse diseases, like neurodegenerative disorders, metabolic syndrome, sarcopenia, cardiac pathophysiology and physiological processes like aging. In this review, we analyze the implication of MB in several diseases in which the MB pathway is affected. Furthermore, we describe therapeutical interventions on MB targets to boost MB for the prevention and treatment of human diseases. Furthermore, evidence based results and the knowledge gained during last years for some of these drugs aim us hypothesize about the value of a given treatment involved in the activation of MB.
authors.forename: Fabian
authors.initials: F
authors.lastname: Sanchis-Gomar
authors.forename: José Luis
authors.initials: JL
authors.lastname: García-Giménez
authors.forename: Mari Carmen
authors.initials: MC
authors.lastname: Gómez-Cabrera
authors.affiliation: Department of Physiology. Faculty of Medicine and Dentistry, University of Valencia., Av. Blasco Ibañez, 15, Valencia, E46010 Spain. federico.v.pallardo@uv.es.
authors.forename: Federico V
authors.initials: FV
authors.lastname: Pallardó
mesh_terms: D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D006304:Health Status; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000188:drug therapy / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014157:Transcription Factors / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D014157:Transcription Factors