title: Iron-catalyzed C(sp(2))-H and C(sp(3))-H arylation by triazole assistance.
abstract: Modular 1,2,3-triazoles enabled iron-catalyzed CH arylations with broad scope. The novel triazole-based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user-friendly iron-catalyzed C(sp(2) )H functionalizations of arenes and alkenes with excellent chemo- and diastereoselectivities. The versatile iron catalyst also proved applicable for challenging C(sp(3) )H functionalizations, and proceeds by an organometallic mode of action. The triazole-assisted CH activation strategy occurred under remarkably mild reaction conditions, and the auxiliary was easily removed in a traceless fashion. Intriguingly, the triazole group proved superior to previously used auxiliaries.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany) http://www.org.chemie.uni-goettingen.de/ackermann/
authors.forename: Qing
authors.initials: Q
authors.lastname: Gu
authors.forename: Hamad H
authors.initials: HH
authors.lastname: Al Mamari
authors.forename: Karolina
authors.initials: K
authors.lastname: Graczyk
authors.forename: Emelyne
authors.initials: E
authors.lastname: Diers
authors.forename: Lutz
authors.initials: L
authors.lastname: Ackermann
mesh_terms: D002384:Catalysis; D007501:Iron / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D014230:Triazoles; D007501:Iron
keywords: CH activation; chelation; iron; ruthenium; triazoles