title: [Involvement of transcriptional factor induced by hypoxia in the neuronal mechanisms of adaptation to psychoemotional and hypoxic stress].
abstract: Using quantitative immunohistochemistry, neuronal expression of alpha-subunit of the transcriptional factor HIF-1 in hippocampus and neocortex of rats in response to pathogenic psychoemotional (model of posttraumatic stress disorder, PTSD) and hypoxic (severe hypobaric hypoxia, 180 Torr, 3 h), as well as to neuroprotective exposures to hypoxic pre- and postconditioning has been studied. Elongated overexpression of HIF-1alpha in hippocampus and neocortex of rats in response to the psychoemotional stress in PTSD paradigm, but not hypoxic stress, has been observed. Hypoxic pre- and postconditioning with mild hypobaric hypoxia (360 Torr, 2 h, 3 trials spaced at 24 h), those induced adaptation to the psychoemotional stress, abolished the elongated HIF-1alpha overexpression. Hypoxic postconditioning which improved structure and functional rehabilitation following severe hypoxic stress up-regulated HIF-1alpha expression in the brain neurons of rats survived severe hypoxia. The findings indicate that transcription factor HIF-1 is particularly involved in the processes of adaptation/ maladaptation to the action of injurious stresses, but its role depends upon the nature of stressor.
authors.forename: E A
authors.initials: EA
authors.lastname: Rybnikova
authors.forename: K A
authors.initials: KA
authors.lastname: Baranova
authors.forename: T S
authors.initials: TS
authors.lastname: Glushchenko
authors.forename: O V
authors.initials: OV
authors.lastname: Vetrovoĭ
authors.forename: M V
authors.initials: MV
authors.lastname: Sidorova
authors.forename: V I
authors.initials: VI
authors.lastname: Portnichenko
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D006624:Hippocampus / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology* / Q000523:psychology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000096:biosynthesis*; D007150:Immunohistochemistry; D008297:Male; D019579:Neocortex / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism / Q000503:physiopathology; D013315:Stress, Psychological / Q000378:metabolism* / Q000503:physiopathology
chemical_list: C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit