title: [Nicotinamide phosphoribosyltransferase and its roles in cancer].
abstract: Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme for synthesis of nicotinamide adenine dinucleotide in mammalian cells. Recent studies show that Nampt also works as a cytokine that exerts insulin-mimetic effects by binding to the insulin receptor, induces B-cell differentiation, inhibits neutrophil apoptosis, and affects immune and inflammatory functions. This review is focused on current knowledge regarding the structure and function of Nampt and its roles in carcinogenesis.
authors.affiliation: Department of Thoracic Surgery,Zhejiang Cancer Hospital,Hangzhou 310022,China.
authors.forename: Xiao-fang
authors.initials: XF
authors.lastname: Xu
authors.affiliation: Department of Thoracic Surgery,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.
authors.forename: Ming
authors.initials: M
authors.lastname: Wu
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000201:enzymology*; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism* / Q000502:physiology
chemical_list: D054409:Nicotinamide Phosphoribosyltransferase