title: Analysis of antithrombotic therapy in elderly patients with atrial fibrillation.
abstract: This study aimed to analyze the impact factors and outcome of antithrombotic therapy in elderly patients over 65 years old that suffered from atrial fibrillation (AF). A total of 256 elderly patients with AF over 65 years old were divided into 3 groups: 65-74 years old (N = 86), 75-84 years old (N = 122), and over 85 years old (N = 48). The clinical characteristics, antithrombotic therapy, and its related impact factors were retrospectively analyzed. Of all patients, 187 received antithrombotic therapy. In the 65-74 year-old group, 78 patients received antiplatelet treatment (90.7%) and 5 patients received anticoagulation treatment (5.8%). In the 75-84 year-old group, 76 patients received antiplatelet treatment (62.3%) and 14 patients received anticoagulation treatment (11.5%). In the group of over 85 year-olds, 33 patients received antiplatelet therapy (68.8%) and 4 patients received anticoagulation treatment (8.3%). Eleven patients had deep vein thrombosis and atrial thrombosis during antiplatelet therapy (5.9%), 5 patients had gastrointestinal hemorrhage after antiplatelet therapy (2.7%), 2 patients had gastrointestinal bleeding, and 3 patients had brain hemorrhage after anticoagulation treatment (21.7%). Suboptimal antithrombotic therapy was observed in the elderly patients with AF, partly owing to the risks of both thromboembolism and bleeding.
authors.affiliation: First Geriatric Cardiology Division of South Building, Chinese PLA General Hospital, Beijing, China.
authors.forename: W Q
authors.initials: WQ
authors.lastname: Gao
authors.affiliation: First Geriatric Cardiology Division of South Building, Chinese PLA General Hospital, Beijing, China.
authors.forename: Y T
authors.initials: YT
authors.lastname: Guo
authors.affiliation: First Geriatric Cardiology Division of South Building, Chinese PLA General Hospital, Beijing, China.
authors.forename: J L
authors.initials: JL
authors.lastname: Ma
authors.affiliation: First Geriatric Cardiology Division of South Building, Chinese PLA General Hospital, Beijing, China.
authors.forename: P
authors.initials: P
authors.lastname: Zhu
authors.affiliation: First Geriatric Cardiology Division of South Building, Chinese PLA General Hospital, Beijing, China.
authors.forename: Y T
authors.initials: YT
authors.lastname: Wang
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D006470:Hemorrhage / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D008297:Male; D020521:Stroke / Q000139:chemically induced / Q000473:pathology; D016896:Treatment Outcome; D014859:Warfarin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D014859:Warfarin