title: Effects of isotretinoin on the platelet counts and the mean platelet volume in patients with acne vulgaris.
abstract: Aim. The aim of this study was to evaluate the platelet counts and the mean platelet volume in patients who received isotretinoin for the treatment of acne vulgaris. Method. A total of 110 patients were included in this retrospective study. Complete blood count parameters were recorded prior to and three-months following the treatment. Results. Both platelet counts and the mean platelet volume were significantly decreased following the treatment. No significant differences were noted on the levels of hemoglobin, hematocrit, and white blood cell count. Conclusion. Platelet counts and mean platelet volume significantly decreased following isotretinoin treatment. Since the decrease of platelet counts and the mean platelet volume was seen concomitantly, it is concluded that the effect of isotretinoin was through the suppression of bone marrow.
authors.affiliation: Department of Dermatology, Konya Training and Research Hospital, Meram, Konya 42023, Turkey.
authors.forename: Arzu
authors.identifier: 0000-0001-5372-0712
authors.initials: A
authors.lastname: Ataseven
authors.affiliation: Department of Hematology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya 42080, Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Ugur Bilgin
mesh_terms: D000152:Acne Vulgaris / Q000097:blood / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D048429:Cell Size / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D010976:Platelet Count; D014212:Tretinoin / Q000494:pharmacology / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D014212:Tretinoin