title: [The effect of aerobic exercise on serum IL-4 and TNF-alpha of patients with allergic rhinitis].
abstract: OBJECTIVE
  To investigate the effect of aerobic exercise on immune factor IL-4, TNF-alpha in patients with allergic rhinitis, which provide a theoretical basis for the treatment of allergic rhinitis.
  
  
  METHODS
  Thirty-two allergic rhinitis patients were selected and divided into a control group (14 people) and the experimental group (18 people). During the treatment, both groups receive conventional symptomatic treatment. Meanwhile, aerobic exercise therapy is applied to the experimental group for 40 - 60 minutes a day, 3 - 4 days a week. Serum IL-4, TNF-alpha and allergic rhinitis symptoms graded scoring were tested before and after 6 month therapy.
  
  
  RESULTS
  After six months of exercise intervention, the 11-4, and TNF-alpha levels of experimental group were significantly lower than the level of control group. The symptoms score is also significantly decreased in experimental group.
  
  
  CONCLUSIONS
  Aerobic exercise had good therapeutic effect in patients with allergic rhinitis. The mechanism may be that aerobic exercise can reduce the level of IL-4 and TNF-alpha, which can relieve infiltration and activation of inflammatory cells.
authors.forename: Hongying
authors.initials: H
authors.lastname: Fu
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D015444:Exercise; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D015847:Interleukin-4 / Q000097:blood*; D008297:Male; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000097:blood* / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
chemical_list: D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4