title: Modulatory role of D-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients.
abstract: Polycystic ovary syndrome (PCOS) is a common endocrine condition that affects fertility through oligo-ovulation, hyperandrogenism and polycystic morphology of the ovaries. Since it has been demonstrated a high incidence of insulin resistance in PCOS patients, our study aimed to evaluate the efficacy of the integrative treatment with D-chiro-inositol (DCI) (500 mg die, per os, for 12 weeks) on hormonal parameters and insulin sensitivity in a group of overweight/obese PCOS patients (body mass index; BMI > 26). After the treatment, interval several endocrine parameters improved (luteinizing hormone [LH], LH/follicle stimulating hormone [FSH], androstenedione and insulin), insulin response to oral glucose tolerance test reported the significant improvement of insulin sensitivity as well as the gonadotropin-releasing hormone (GnRH)-induced (10 µg, in bolus) LH response. BMI decreased, though no lifestyle modification was requested. When data were analyzed according to the presence or absence of first-grade diabetic relatives, PCOS patients with diabetic relatives showed greater improvement after DCI administration. In conclusion DCI administration is effective in restoring better insulin sensitivity and an improved hormonal pattern in obese hyperinsulinemic PCOS patients, in particular, in hyperinsulinemic PCOS patients who have diabetic relatives.
authors.affiliation: Department of Obstetrics and Gynecology, Gynecological Endocrinology Centre, University of Modena and Reggio Emilia , Modena , Italy.
authors.forename: Alessandro D
authors.initials: AD
authors.lastname: Genazzani
authors.forename: Susanna
authors.initials: S
authors.lastname: Santagni
authors.forename: Erika
authors.initials: E
authors.lastname: Rattighieri
authors.forename: Elisa
authors.initials: E
authors.lastname: Chierchia
authors.forename: Giulia
authors.initials: G
authors.lastname: Despini
authors.forename: Giulia
authors.initials: G
authors.lastname: Marini
authors.forename: Alessia
authors.initials: A
authors.lastname: Prati
authors.forename: Tommaso
authors.initials: T
authors.lastname: Simoncini
mesh_terms: D000328:Adult; D015992:Body Mass Index; D019587:Dietary Supplements; D005192:Family Health; D005260:Female; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use; D007294:Inositol / Q000737:chemistry / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D007558:Italy; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D009765:Obesity / Q000150:complications*; D050177:Overweight / Q000150:complications; D010903:Pituitary Gland, Anterior / Q000378:metabolism* / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000178:diet therapy* / Q000503:physiopathology; D013237:Stereoisomerism
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D007987:Gonadotropin-Releasing Hormone; D007294:Inositol; D007986:Luteinizing Hormone
keywords: Body mass index; insulin resistance; insulin sensitizer; polycystic ovary syndrome