title: Allostery and compartmentalization: old but not forgotten.
abstract: Homeostasis is an essential capability of all cells mediated by complex and diverse regulatory networks. Despite this complexity, many of the fundamental regulatory mechanisms used by cells have been evolutionarily conserved. It is thus somewhat surprising that the apparent physiologic significance of these mechanisms has been experimentally neglected. Here, we review 2 widely recognized regulatory mechanisms, allostery and compartmentalization, which exemplify this dissociation in our current understanding of the microbial pathogen, Mycobacterium tuberculosis.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
authors.forename: Hyungjin
authors.initials: H
authors.lastname: Eoh
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Department of Microbiology & Immunology, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: kyr9001@med.cornell.edu.
authors.forename: Kyu Y
authors.initials: KY
authors.lastname: Rhee
mesh_terms: D000494:Allosteric Regulation; D002451:Cell Compartmentation; D009169:Mycobacterium tuberculosis / Q000378:metabolism / Q000502:physiology*; D013312:Stress, Physiological