title: Genetic influences on hallux valgus in Koreans: the healthy twin study.
abstract: Hallux valgus (HV) is a common foot deformity of multifactorial etiology, but knowledge about the relative importance of genetics and environments on HV has been limited. In order to estimate genetic influences on HV, 1,265 adults, including 175 monozygotic twin (MZ) pairs, 31 dizygotic twin (DZ) pairs, and 853 first-degree singleton family members of the twins were included from the Healthy Twin study, a population-based twin-family cohort in Korea. All participants underwent foot examination and weight-bearing radiographic assessment (anterior-posterior and lateral) in addition to a general health survey. Of the subjects, 208 (16.4%) were classified as HV (as HV angle >20°). The genetic influence on HV was estimated to be substantial; the heritability of HV was 0.51 (95% CI 0.42-0.59) and the heritability of HV angle was 0.47 (0.38-0.56), while contributions from shared environmental effects were negligible. These findings suggest that genetic factors play an important role in determining HV deformity.
authors.affiliation: Rehabilitation Medicine, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Mulgeum, Yangsan, Gyeongnam, South Korea.
authors.forename: Chang-Hyung
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
authors.forename: Sooji
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
authors.forename: Hyojeong
authors.initials: H
authors.lastname: Kang
authors.affiliation: Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
authors.forename: Da-Eun
authors.initials: DE
authors.lastname: Jung
authors.affiliation: Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
authors.forename: Yun-Mi
authors.initials: YM
authors.lastname: Song
authors.affiliation: Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea.
authors.forename: Kayoung
authors.initials: K
authors.lastname: Lee
authors.affiliation: KT Lee Orthopedic Hospital, Seoul, Korea.
authors.forename: Kyungtai
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
authors.forename: Jihye
authors.initials: J
authors.lastname: Hwang
authors.affiliation: Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
authors.forename: Joohon
authors.initials: J
authors.lastname: Sung
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D005260:Female; D006215:Hallux Valgus / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D011859:Radiography; D056910:Republic of Korea; D014429:Twins, Dizygotic / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*