title: Dual platinum and pyrrolidine catalysis in the direct alkylation of allylic alcohols: selective synthesis of monoallylation products.
abstract: A dual platinum- and pyrrolidine-catalyzed direct allylic alkylation of allylic alcohols with various active methylene compounds to produce products with high monoallylation selectivity was developed. The use of pyrrolidine and acetic acid was essential, not only for preventing undesirable side reactions, but also for obtaining high monoallylation selectivity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, CREST, JST, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582 (Japan) http://green.phar.kyushu-u.ac.jp/ http://www.organomet.chem.es.osaka-u.ac.jp/
authors.forename: Ryozo
authors.initials: R
authors.lastname: Shibuya
authors.forename: Lu
authors.initials: L
authors.lastname: Lin
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Nakahara
authors.forename: Kazushi
authors.initials: K
authors.lastname: Mashima
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohshima
mesh_terms: D000478:Alkylation; D000498:Allyl Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D010984:Platinum / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D020005:Propanols; D011759:Pyrrolidines; C006463:allyl alcohol; D010984:Platinum; C032519:pyrrolidine
keywords: allylic alkylation; homogeneous catalysis; organocatalysis; platinum; pyrrolidine