title: Expression of the monocyte chemotactic protein-1-induced protein 1 decreases human neuroblastoma cell survival.
abstract: The importance of monocyte chemotactic protein-1-induced protein 1 (MCPIP1) in the negative regulation of inflammatory reactions has already been extensively studied. However, its role in cancer is not yet established. We studied MCPIP1 gene expression in primary human neuroblastomas and several neuroblastoma cell lines. Our results showed a lack of MCPIP1 expression in primary neuroblastoma tumors. Moreover, it was found that the low expression of the protein measured in human neuroblastoma cell lines might be important for neuroblastoma survival, since enforced MCPIP1 gene expression in human neuroblastoma BE(2)-C cells caused a significant decrease in neuroblastoma cell viability and proliferation.
authors.affiliation: Laboratory of Molecular Genetics and Virology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Skalniak
authors.affiliation: Laboratory of Molecular Genetics and Virology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Boratyn
authors.affiliation: Laboratory of Molecular Genetics and Virology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
authors.forename: Sylwia D
authors.initials: SD
authors.lastname: Tyrkalska
authors.affiliation: Laboratory of Molecular Genetics and Virology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
authors.forename: Irena
authors.initials: I
authors.lastname: Horwacik
authors.affiliation: Laboratory of Molecular Genetics and Virology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Durbas
authors.affiliation: Department of Pathology, Institute 'Pomnik‑Centrum Zdrowia Dziecka', 04-730 Warsaw, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Lastowska
authors.affiliation: Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Jura
authors.affiliation: Laboratory of Molecular Genetics and Virology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Rokita
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics*; D002470:Cell Survival / Q000235:genetics; D004722:Endoribonucleases / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D009447:Neuroblastoma / Q000235:genetics*; D012260:Ribonucleases; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*; D014162:Transfection
chemical_list: D014157:Transcription Factors; D004722:Endoribonucleases; D012260:Ribonucleases; C510646:ZC3H12A protein, human