title: Luliconazole: a review of a new antifungal agent for the topical treatment of onychomycosis.
abstract: Luliconazole is a novel, broad-spectrum, imidazole antifungal under development in the USA as a treatment for dermatophytic skin and nail infections. In vitro, luliconazole is one of the most potent antifungal agents against filamentous fungi including dermatophytes. Luliconazole has been formulated in a 10% solution with unique molecular properties, which allow it to penetrate the nail plate and rapidly achieve fungicidal levels in the nail unit. These properties make luliconazole a potent compound in the treatment of onychomycosis. This article reviews the development of luliconazole solution, 10% its molecular properties, preclinical and clinical data and its future perspectives for the treatment of fungal infections.
authors.affiliation: Weill Cornell Medical College, Cornell Medical School, New York, NY, USA.
authors.forename: Richard K
authors.initials: RK
authors.lastname: Scher
authors.forename: Norifumi
authors.initials: N
authors.lastname: Nakamura
authors.forename: Amir
authors.initials: A
authors.lastname: Tavakkol
mesh_terms: D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage*; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D014009:Onychomycosis / Q000188:drug therapy*; D019999:Pharmaceutical Solutions / Q000008:administration & dosage
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D019999:Pharmaceutical Solutions; C112528:luliconazole
keywords: Luliconazole; Trichophyton rubrum; antifungal; dermatophyte; onychomycosis; topical