title: Helicobacter pylori infection: A brief overview on alternative natural treatments to conventional therapy.
abstract: Helicobacter pylori is a human gastric pathogen considered as the etiologic agent of several gastric disorders, that may range from chronic gastritis to more severe outcomes, including gastric cancer. The current therapeutic scheme relies on the combination of several pharmacological substances, namely antibiotics and proton pump inhibitors. However, the cure rates obtained have been declining over the years, mostly due to bacterial resistance to antibiotics. In this context, the use of non-antibiotic substances is of the utmost importance regarding H. pylori eradication. In this review, we present different classes of compounds obtained from natural sources that have shown to present anti-H. pylori potential; we briefly highlight their possible use in the context of developing new therapeutic approaches.
authors.affiliation: a Centro de Biotecnologia Agrícola e Agro-Alimentar do Alentejo , Rua Pedro Soares, Beja , Portugal .
authors.forename: Paula
authors.initials: P
authors.lastname: Parreira
authors.affiliation: a Centro de Biotecnologia Agrícola e Agro-Alimentar do Alentejo , Rua Pedro Soares, Beja , Portugal .
authors.forename: M
authors.initials: M
authors.lastname: Fátima Duarte
authors.affiliation: b Instituto de Patologia e Imunologia Molecular da Universidade do Porto , Porto , Portugal .|c Faculdade de Medicina , Universidade do Porto , Porto , Portugal .|d Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto , Porto , Portugal , and.
authors.forename: Celso A
authors.initials: CA
authors.lastname: Reis
authors.affiliation: d Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto , Porto , Portugal , and.|e Instituto de Engenharia Biomédica, Universidade do Porto , Porto , Portugal.
authors.forename: M Cristina L
authors.initials: MC
authors.lastname: Martins
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D057005:Bioengineering / Q000379:methods; D019468:Disease Management; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology* / Q000628:therapy*; D016480:Helicobacter pylori / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008517:Phytotherapy / Q000379:methods; D012307:Risk Factors; D017211:Treatment Failure; D016896:Treatment Outcome; D037521:Virulence Factors
chemical_list: D000900:Anti-Bacterial Agents; D037521:Virulence Factors
keywords: Bioactive compounds; bioengineering; gastric cancer; new therapies; phytotherapy