title: Effectiveness of estrogen in the prevention of intrauterine adhesions after hysteroscopic septal resection: a prospective, randomized study.
abstract: OBJECTIVE
  The aim of this prospective randomized study was to evaluate the efficacy of estrogen in preventing intrauterine adhesions following hysteroscopic septal resection and to investigate its effect on reproductive outcome.
  
  
  METHODS
  After hysteroscopic septal resection, 90 women received either estrogen or placebo (n=45 per group) for 30 days. A second-look hysteroscopy was performed after 2 months. All pregnancies occurring during the study period were recorded.
  
  
  RESULTS
  Adhesions developed in three of 43 (6.9%) patients in the control group compared to none in the estrogen group. This difference was not statistically significant (P=0.24). Regarding reproductive outcome, the differences between the two groups were also not significant.
  
  
  CONCLUSIONS
  Estrogen treatment was not found to prevent intrauterine adhesions or improve reproductive outcome after hysteroscopic septal resection.
authors.affiliation: Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Kallol Kumar
authors.initials: KK
authors.lastname: Roy
authors.forename: Neha
authors.initials: N
authors.lastname: Negi
authors.forename: Murali
authors.initials: M
authors.lastname: Subbaiah
authors.forename: Sunesh
authors.initials: S
authors.lastname: Kumar
authors.forename: Jai Bhagwan
authors.initials: JB
authors.lastname: Sharma
authors.forename: Neeta
authors.initials: N
authors.lastname: Singh
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004311:Double-Blind Method; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015907:Hysteroscopy / Q000009:adverse effects; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control*; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control; D014599:Uterus / Q000002:abnormalities / Q000187:drug effects* / Q000601:surgery; D055815:Young Adult
chemical_list: D004966:Estrogens, Conjugated (USP); D004958:Estradiol
keywords: adhesions; estrogen treatment; hysteroscopy; reproductive outcome; septal resection