title: Human polyethylene granuloma tissues inhibit bone healing in a novel xenograft animal model.
abstract: During revision of a conventional polyethylene joint replacement, surgeons usually remove the source of osteolysis (polyethylene) but cannot always remove all of the polyethylene granuloma tissues. We developed a human/rat xenograft model to investigate the effects of polyethylene granuloma tissues on bone healing. Human osteoarthritic and periprosthetic tissues collected during primary and revision hip arthroplasty surgeries were transplanted into the distal femora of athymic nude rats. After 3 weeks in vivo, there was a significant difference in the bone volume fraction (Vf ) between empty, primary, and revision defects (p = 0.02), with a lower Vf in defects with revision granuloma tissues compared to defects with primary osteoarthritic tissues. Polyethylene granuloma tissues in trabecular bone defects inhibited bone healing. Therefore, debridement around a metal-on-polyethylene hip replacement may shorten the time it takes to achieve secondary stability around a revision hip replacement.
authors.affiliation: Surgical and Orthopaedic Research Laboratories, Clinical Sciences Building, Level 1, Prince of Wales Hospital, Randwick, NSW, 2031, Australia; Specialist Orthopaedic Group, Mater Clinic, Suite 1.08, 3-9 Gillies Street, Wollstonecraft, NSW, 2065, Australia.
authors.forename: Christina I
authors.initials: CI
authors.lastname: Esposito
authors.forename: Rema A
authors.initials: RA
authors.lastname: Oliver
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Campbell
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.forename: William L
authors.initials: WL
authors.lastname: Walter
authors.forename: William K
authors.initials: WK
authors.lastname: Walter
authors.forename: William R
authors.initials: WR
authors.lastname: Walsh
mesh_terms: D000818:Animals; D019644:Arthroplasty, Replacement, Hip; D003646:Debridement; D015745:Granuloma, Foreign-Body / Q000503:physiopathology*; D064593:Heterografts; D006801:Humans; D016348:Osseointegration / Q000502:physiology; D010014:Osteolysis / Q000601:surgery*; D020959:Polyethylene / Q000009:adverse effects*; D051381:Rats; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
chemical_list: D020959:Polyethylene
keywords: hip; osteolysis; periprosthetic tissues; polyethylene; wear