title: Synthesis and anticonvulsant activity of some new pyrazolo[3,4-b]pyrazines and related heterocycles.
abstract: A series of new pyrazolo[3,4-b]pyrazines containing, 1,2,4-oxadiazolyl, thiadiazolyl, imidazothiadiazolyl, thiazolidinonyl, substituents and other different substituents, was synthesized using 1,6-diphenyl-3-methyl-lH-pyrazolo[3,4-b]pyrazine-5-carbonitrile (2) as a starting material. Some of the newly prepared compounds were evaluated for their anticonvulsant activity. Compounds 9a, 13a-d and 14a at a dose of 10mg/kg showed very significant anticonvulsant activity and increased the latency time of PTZ-induced tonic seizures. Compound 9b showed significant effect.
authors.affiliation: Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt.
authors.forename: Abdel-Rahman
authors.initials: AR
authors.lastname: Farghaly
authors.affiliation: Department of Chemistry, Faculty of Science, Ibb University, Yemen.
authors.forename: Sabah
authors.initials: S
authors.lastname: Esmail
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abdel-Zaher
authors.affiliation: Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt.
authors.forename: Ali
authors.initials: A
authors.lastname: Abdel-Hafez
authors.affiliation: Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt. Electronic address: elkashef15@hotmail.com.
authors.forename: Hussein
authors.initials: H
authors.lastname: El-Kashef
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010433:Pentylenetetrazole; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D006571:Heterocyclic Compounds; D011719:Pyrazines; C508194:pyrazolo(3,4-b)pyrazine; D010433:Pentylenetetrazole
keywords: Anticonvulsant activity; Imidazothiadiazoles; Oxadiazoles; Pyrazolo[3,4-b]pyrazines; Thiadiazoles; Thiazolidinones