title: Intraocular pressure fluctuation and glaucoma progression: what do we know?
abstract: While mean intraocular pressure (IOP) has long been known to correlate with glaucomatous damage, the role of IOP fluctuation is less clearly defined. There is extensive evidence in the literature for and against the value of short-term and long-term IOP fluctuation in the evaluation and prognosis of patients with glaucoma. We present here the arguments made by both sides, as well as a discussion of the pitfalls of prior research and potential directions for future studies. Until a reliable method is developed that allows for constant IOP monitoring, many variables will continue to hinder us from drawing adequate conclusions regarding the significance of IOP variation.
authors.affiliation: Nassau University Medical Center, East Meadow, New York, USA.
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Leidl
authors.affiliation: Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Choi
authors.affiliation: Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Zeba A
authors.initials: ZA
authors.lastname: Syed
authors.affiliation: Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA Harvard Medical School, Boston, Massachusetts, USA Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA Boston Eye Group, Boston, Massachusetts, USA.
authors.forename: Samir A
authors.initials: SA
authors.lastname: Melki
mesh_terms: D002940:Circadian Rhythm / Q000502:physiology*; D018450:Disease Progression; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D014065:Tonometry, Ocular
keywords: Glaucoma; Intraocular Pressure; Physiology