title: Tumor antigen-/cytokine-pulsed dendritic cells in therapy against lymphoma.
abstract: Adoptive cell therapy using dendritic cells (DCs) is a strategy to deliver tumor antigens in cancer immunotherapy. Co-delivery of antigens to DC with essential components like genes encoding cytokines, chemokines, and other molecules or stimulation with recombinant cytokines is a potential method for designing an effective tumor vaccine protocol. Here, we describe the stimulation of purified splenic- or bone marrow-derived DC with recombinant interleukin-15 (IL-15) in the presence of intact soluble antigen from metastatic lymphoma tumor cells in an experimental animal model.
authors.affiliation: Immunobiology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India.
authors.forename: Sumit K
authors.initials: SK
authors.lastname: Hira
authors.forename: Deepak
authors.initials: D
authors.lastname: Verma
authors.forename: Partha P
authors.initials: PP
authors.lastname: Manna
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000187:drug effects; D000951:Antigens, Neoplasm / Q000276:immunology*; D001854:Bone Marrow Cells / Q000166:cytology; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology* / Q000637:transplantation; D005260:Female; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D019409:Interleukin-15 / Q000494:pharmacology*; D053208:Kaplan-Meier Estimate; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D051379:Mice; D013154:Spleen / Q000166:cytology
chemical_list: D000951:Antigens, Neoplasm; D019409:Interleukin-15