title: Large small cell carcinoma of anorectal canal.
abstract: Neurofibromatosis type-1 (NF1), also known as Von Recklinghausen disease, is an autosomal dominant disorder with incidence of one per 4000. Neurofibromas are benign, heterogeneous, peripheral nerve sheath tumors coming up from the connective tissue of peripheral nerve sheaths, particularly the endoneurium. Visceral involvement in disseminated neurofibromatosis is considered rare. Neurofibroma occurs most frequently in the stomach and jejunum, but colon and anorectal canal may also be involved. Gastrointestinal neurofibromas may lead to bleeding, obstruction, intussusception, protein-losing enteropathy and bowel perforation. We encountered a case of diffusely involving the anorectal area by huge neurofibroma, which resulted in pelvic pain with watery diarrhea and urgency.
authors.affiliation: Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Laparoscopic Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. colorectal@sums.ac.ir.
authors.forename: Leila
authors.initials: L
authors.lastname: Ghahramani
authors.affiliation: Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mohammadianpanah
authors.affiliation: Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, 2Laparoscopic Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Seyed Vahid
authors.initials: SV
authors.lastname: Hosseini
authors.affiliation: Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Masood
authors.initials: M
authors.lastname: Hosseinzade
authors.affiliation: Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Izadpanah
authors.affiliation: Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Saba
authors.initials: S
authors.lastname: Ebrahimian
authors.affiliation: Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Laparoscopic Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Alimohammad
authors.initials: A
authors.lastname: Bananzadeh
mesh_terms: D001005:Anus Neoplasms / Q000175:diagnosis / Q000628:therapy; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000628:therapy; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000628:therapy