title: Multifactor dimensionality reduction analysis of the correlation of Chinese medicine syndrome evolvement and cardiovascular events in patients with stable coronary heart disease.
abstract: OBJECTIVE
  To analyze the correlation of Chinese medicine syndrome evolvement and cardiovascular: events in patients with stable coronary heart disease (CHD).
  
  
  METHODS
  This prospective cohort study investigated and: collected the clinical information of patients with stable CHD and observed the syndrome type at the baseline and 6-month at follow-up, as well as the cardiovascular events during the 6-month and 12-month follow-up. The patients were divided into the event group and the non-event group. The interaction and the impact of syndrome evolvement on cardiovascular events were examined through multifactor dimensionality reduction (MDR) analysis and the results were verified by Chi-square test.
  
  
  RESULTS
  Totally 1,333 of 1,503 stable CHD patients enrolled met the inclusion criteria: of MDR analysis. Among them, 959 (71.9%) cases were males and 374 (28.1%) cases were females. Thirty seven cases had cardiovascular events during 6 to 12 months after the study began. The results of the MDR analysis and verification using Chi-square test showed that the development of cardiovascular events was positively correlated with interaction between blood stasis and toxic syndrome at the baseline, blood stasis at the baseline and qi deficiency at the 6-month follow-up, toxic syndrome at the baseline and qi deficiency at the 6-month follow-up, toxic syndrome at the base line and blood stasis at the 6-month follow-up, qi deficiency and blood stasis at the 6-month follow-up (P<0.05 for all).
  
  
  CONCLUSIONS
  Blood stasis, toxic syndrome and qi deficiency are important factors of stable CHD. There: are positive correlation between cardiovascular events and syndrome evolution from blood stasis to qi deficiency, from toxic syndrome to qi deficiency and from toxic syndrome to blood stasis, indicating the pathogenesis of toxin consuming qi, toxin leading to blood-stasis in stable CHD patients prone to recurrent cardiovascular events.
authors.affiliation: Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiao
authors.forename: Si-wei
authors.initials: SW
authors.lastname: Li
authors.forename: Qing-hua
authors.initials: QH
authors.lastname: Shang
authors.forename: Chang-geng
authors.initials: CG
authors.lastname: Fu
authors.forename: Zhu-ye
authors.initials: ZY
authors.lastname: Gao
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.forename: Da-zhuo
authors.initials: DZ
authors.lastname: Shi
authors.forename: Ke-ji
authors.initials: KJ
authors.lastname: Chen
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology; D017023:Coronary Angiography; D003327:Coronary Disease / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D058011:Multifactor Dimensionality Reduction; D013577:Syndrome