title: Regan isoenzyme of alkaline phosphatase as a tumour marker for renal cell carcinoma.
abstract: Alkaline phosphatase is an enzyme present in all tissues of the human body. Several isoforms of this enzyme have been described with different catalytic nature, stability and antigenic structure. Rises in the activity of alkaline phosphatase are recognised in various states including bone diseases, liver disease, pregnancy, hyperthyroidism and malignant processes. The Regan isoenzyme, a rare variant of placental alkaline phosphatase, has been identified circulating in association with various tumours. The reported case describes a rising Regan isoform of alkaline phosphatase concentrations that led to a new diagnosis of occult renal cell carcinoma and persistently elevated activity postoperatively signposting persistent or recurrent disease.
authors.affiliation: Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK jakubbukowczan@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Bukowczan
authors.affiliation: Department of Clinical Biochemistry, South Tees Hospitals NHS Foundation Trust, James Cook University Hospital, Middlesbrough, UK.
authors.forename: S
authors.initials: S
authors.lastname: Pattman
authors.affiliation: Department of Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
authors.forename: F
authors.initials: F
authors.lastname: Jenkinson
authors.affiliation: Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
authors.forename: R
authors.initials: R
authors.lastname: Quinton
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000628:therapy; D017115:Catheter Ablation; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D007680:Kidney Neoplasms / Q000097:blood* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D007527:Isoenzymes; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental
keywords: Isoenzymes; amylase; cancer