title: Next-generation heteronuclear decoupling for high-field biomolecular NMR spectroscopy.
abstract: Ultra-high-field NMR spectroscopy requires an increased bandwidth for heteronuclear decoupling, especially in biomolecular NMR applications. Composite pulse decoupling cannot provide sufficient bandwidth at practical power levels, and adiabatic pulse decoupling with sufficient bandwidth is compromised by sideband artifacts. A novel low-power, broadband heteronuclear decoupling pulse is presented that generates minimal, ultra-low sidebands. The pulse was derived using optimal control theory and represents a new generation of decoupling pulses free from the constraints of periodic and cyclic sequences. In comparison to currently available state-of-the-art methods this novel pulse provides greatly improved decoupling performance that satisfies the demands of high-field biomolecular NMR spectroscopy.
authors.affiliation: Department Chemie, Technische Universität München, Lichtenbergstr. 4, 85747 Garching (Germany) http://www.org.chemie.tu-muenchen.de/glaser.
authors.forename: Franz
authors.initials: F
authors.lastname: Schilling
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Warner
authors.forename: Naum I
authors.initials: NI
authors.lastname: Gershenzon
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Skinner
authors.forename: Michael
authors.initials: M
authors.lastname: Sattler
authors.forename: Steffen J
authors.initials: SJ
authors.lastname: Glaser
mesh_terms: D003198:Computer Simulation; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*
keywords: NMR spectroscopy; decoupling sidebands; nucleic acids; proteins; ultra-broadband decoupling