title: Lectin approaches for glycoproteomics in FDA-approved cancer biomarkers.
abstract: The nine FDA-approved protein biomarkers for the diagnosis and management of cancer are approaching maturity, but their different glycosylation compositions relevant to early diagnosis still remain practically unexplored at the sub-glycoproteome scale. Lectins generally exhibit strong binding to specific sub-glycoproteome components and this property has been quite poorly addressed as the basis for the early diagnosis methods. Here, we discuss some glycoproteome issues that make tackling the glycoproteome particularly challenging in the cancer biomarkers field and include a brief view for next generation technologies.
authors.affiliation: Laboratory of Molecular Genetics, Institute of General Genetics and Cytology, Almaty 050060, Kazakhstan.
authors.forename: Haitham A
authors.initials: HA
authors.lastname: Badr
authors.forename: Dina M M
authors.initials: DM
authors.lastname: Alsadek
authors.forename: Ashraf A
authors.initials: AA
authors.lastname: Darwish
authors.forename: Abdelaleim I
authors.initials: AI
authors.lastname: Elsayed
authors.forename: Bakhytzhan O
authors.initials: BO
authors.lastname: Bekmanov
authors.forename: Elmira M
authors.initials: EM
authors.lastname: Khussainova
authors.forename: Xueji
authors.initials: X
authors.lastname: Zhang
authors.forename: William C S
authors.initials: WC
authors.lastname: Cho
authors.forename: Leyla B
authors.initials: LB
authors.lastname: Djansugurova
authors.forename: Chen-Zhong
authors.initials: CZ
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis* / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D037102:Lectins / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D020543:Proteome / Q000032:analysis* / Q000378:metabolism; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D014408:Biomarkers, Tumor; D006023:Glycoproteins; D037102:Lectins; D020543:Proteome