title: Epigenetics, chromatin and genome organization: recent advances from the ENCODE project.
abstract: The organization of the genome into functional units, such as enhancers and active or repressed promoters, is associated with distinct patterns of DNA and histone modifications. The Encyclopedia of DNA Elements (ENCODE) project has advanced our understanding of the principles of genome, epigenome and chromatin organization, identifying hundreds of thousands of potential regulatory regions and transcription factor binding sites. Part of the ENCODE consortium, GENCODE, has annotated the human genome with novel transcripts including new noncoding RNAs and pseudogenes, highlighting transcriptional complexity. Many disease variants identified in genome-wide association studies are located within putative enhancer regions defined by the ENCODE project. Understanding the principles of chromatin and epigenome organization will help to identify new disease mechanisms, biomarkers and drug targets, particularly as ongoing epigenome mapping projects generate data for primary human cell types that play important roles in disease.
authors.affiliation: Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Siggens
authors.forename: K
authors.initials: K
authors.lastname: Ekwall
mesh_terms: D002843:Chromatin / Q000502:physiology*; D002874:Chromosome Mapping / Q000379:methods; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D005544:Forecasting; D015894:Genome, Human / Q000235:genetics*; D006657:Histones / Q000235:genetics; D016045:Human Genome Project; D006801:Humans; D050436:Regulatory Elements, Transcriptional / Q000235:genetics; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D002843:Chromatin; D006657:Histones; D014157:Transcription Factors
keywords: DNA methylation; chromatin; epigenetics; histone; transcription