title: Serum prolidase activity in benign joint hypermobility syndrome.
abstract: BACKGROUND
  Moderate joint laxity is widespread in many joints of the body, and this condition is considered to be caused by an abnormality in the collagen structure. This study was carried out to determine the serum prolidase activity in female patients with benign joint hypermobility syndrome (BJHS), and to evaluate its correlation with their clinical features.
  
  
  METHODS
  A total of 45 patients with BJHS and 40 healthy controls were included in the study. All of the patients with BJHS met the Beighton diagnostic criteria. All the patients and the control group underwent a comprehensive examination of the locomotor system and took the New York Posture Rating Test. The examination and test results were recorded. Serum prolidase activity was measured in both the groups.
  
  
  RESULTS
  Prolidase activity was significantly lower in patients with BJHS (479.52 ± 126.50) compared to the healthy controls (555.97 ± 128.77) (p = 0.007). We found no correlation between serum prolidase activity and Beighton scores or New York rating test scores. On the other hand, mean prolidase activity was significantly lower in patients with pes planus or hyperlordosis compared to those without (p = 0.05, p = 0.03, respectively). We did not find such a correlation with the other clinical features.
  
  
  CONCLUSIONS
  Significantly lower prolidase activity in patients with BJHS suggests that prolidase may affect the collagen metabolism and cause hyperlaxity.
authors.affiliation: Department of Physical Medicine and Rehabilition, Division of Rheumatology, Dicle University Faculty of Medicine, Diyarbakir, Turkey. serdaem@hotmail.com.
authors.forename: Serda
authors.initials: S
authors.lastname: Em
authors.forename: Demet
authors.initials: D
authors.lastname: Ucar
authors.forename: Pelin
authors.initials: P
authors.lastname: Oktayoglu
authors.forename: Mehtap
authors.initials: M
authors.lastname: Bozkurt
authors.forename: Mehmet
authors.initials: M
authors.lastname: Caglayan
authors.forename: Ismail
authors.initials: I
authors.lastname: Yıldız
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoglu
authors.forename: Kemal
authors.initials: K
authors.lastname: Nas
mesh_terms: D000328:Adult; D018771:Arthralgia / Q000097:blood / Q000209:etiology; D015415:Biomarkers; D015992:Body Mass Index; D003094:Collagen / Q000378:metabolism; D004150:Dipeptidases / Q000097:blood* / Q000172:deficiency; D005260:Female; D005413:Flatfoot / Q000097:blood / Q000209:etiology; D006801:Humans; D007593:Joint Instability / Q000097:blood* / Q000235:genetics; D007738:Kyphosis / Q000097:blood / Q000209:etiology; D008141:Lordosis / Q000097:blood / Q000209:etiology; D008297:Male; D010808:Physical Examination; D011187:Posture; D012720:Severity of Illness Index; D019534:Shoulder Impingement Syndrome / Q000097:blood / Q000209:etiology; D063189:Symptom Assessment; D013577:Syndrome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003094:Collagen; D004150:Dipeptidases; C022449:proline dipeptidase