title: Pancreatic pain.
abstract: Pain is a common symptom of many diseases. Recently, the pain has been classified and analyzed exactly. Its particular components/types are described to the maximum of their depths and details. That is why each particular pain present in a specific disease (pancreatopathies included) has to be treated according to the presence of the specific type of pain. In diseases of pancreas, there are nociceptive, neuropathic, and inflammatory components of pain participating, frequently. Especially long-lasting, not well-controlled pain sets off the process of neuromodulation. The recent pioneering applications/administrations of various neuromodulatory therapeutic approaches represent the promising discoveries for the treatment of long-term, severe, drug-resistant pain syndromes, including chronic pancreatitis. In this article, we summarized the characteristics of pain, the therapeutic strategy, and algorithms of analgesic treatment (in general and applied for pancreatopathies), including new therapeutic trends and approaches.
authors.affiliation: Second Department of Internal Medicine, St. Anne's University Hospital Brno, Brno, Czech Republic, hankanech@seznam.cz.
authors.forename: Hana
authors.initials: H
authors.lastname: Nechutova
authors.forename: Petr
authors.initials: P
authors.lastname: Dite
authors.forename: Marketa
authors.initials: M
authors.lastname: Hermanova
authors.forename: Ivo
authors.initials: I
authors.lastname: Novotny
authors.forename: Arnost
authors.initials: A
authors.lastname: Martinek
authors.forename: Pavel
authors.initials: P
authors.lastname: Klvana
authors.forename: Bohumil
authors.initials: B
authors.lastname: Kianicka
authors.forename: Miroslav
authors.initials: M
authors.lastname: Soucek
mesh_terms: D059350:Chronic Pain / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D009437:Neuralgia / Q000503:physiopathology / Q000628:therapy; D009473:Neuronal Plasticity / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D009619:Nociceptors / Q000502:physiology; D059408:Pain Management / Q000379:methods; D010179:Pancreas / Q000294:innervation; D010182:Pancreatic Diseases / Q000503:physiopathology* / Q000628:therapy; D050500:Pancreatitis, Chronic / Q000503:physiopathology / Q000628:therapy
chemical_list: D018836:Inflammation Mediators; D018377:Neurotransmitter Agents