title: Which tools may help physicians in female fertility prediction after autologous bone marrow transplantation for lymphoma? A pilot study.
abstract: OBJECTIVE
  The report of our experience on fertility preservation and the validation of some tools useful to predict fertility in young females who underwent haematopoietic cell transplantation for their lymphoma.
  
  
  METHODS
  A retrospective study involving 17 consecutive women of child-bearing age affected by lymphoma and submitted to haematopoietic cell transplantation in our centre.
  
  
  RESULTS
  We described a high rate of parenthood in our patient series: 5 out of 17 (29%) patients became pregnant and 1 out of 5 had two pregnancies. It is suggestive that only patients who received gonadotropin-releasing hormone (GnRH) analogues co-treatment conceaved. Antral follicles number or ovarian volume, ascertained through transvaginal ultrasound before starting treatment, more than anti-Mullerian hormone (AMH) value, are tools that may help physicians to better predict fertility in young females of child-bearing age affected by lymphoma who desire to get pregnant after cancer cares.
  
  
  CONCLUSIONS
  The high rate of maternity we recorded may lead to comfort the young women who hope to become pregnant after cancer cares because pregnancy is possible in a certain percentage of cases even after highly toxic treatments to the ovaries. A higher ovarian volume or a higher number of antral follicles, before treatment start, ensures a greater chance of successful pregnancies. AMH value in lymphoma survivors is not sufficient to guide physicians in fertility predictions.
authors.forename: Lino Del
authors.initials: LD
authors.lastname: Pup
authors.forename: Ernesto
authors.initials: E
authors.lastname: Zanet
authors.forename: Maurizio
authors.initials: M
authors.lastname: Rupolo
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
authors.forename: Umberto
authors.initials: U
authors.lastname: Tirelli
authors.forename: Mario
authors.initials: M
authors.lastname: Mazzucato
authors.forename: Agostino
authors.initials: A
authors.lastname: Steffan
authors.forename: Stefania
authors.initials: S
authors.lastname: Zanussi
authors.forename: Paolo
authors.initials: P
authors.lastname: Doretto
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Michieli
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005298:Fertility; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008223:Lymphoma / Q000453:epidemiology / Q000628:therapy*; D010820:Physicians; D010865:Pilot Projects; D011247:Pregnancy; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D055815:Young Adult
chemical_list: D007987:Gonadotropin-Releasing Hormone
keywords: Anti-Mullerian hormone; Cancer survivorship,; Fertility,; Haematopoietic cell transplantation,