title: Epidemiology and antibiotic resistance in a large Italian teaching hospital.
abstract: We focused our attention on susceptibility profile of Acinetobacter spp., Pseudomonas spp., and Klebsiella spp. isolated from biological specimens at the University Hospital of Salerno between June 2011 and October 2012. Acinetobacter, with a prevalence of Acinetobacter baumannii (97%) presented a high range of resistance to the antimicrobials considered, excluding colistin (COL). Klebsiella spp. isolates, with a prevalence of Klebsiella pneumoniae (90%), presented a variable pattern of resistance [from 9·8% for COL to 50% for levofloxacin (LEV)]. Extended-spectrum beta-lactamases production was detected in 15% of isolates. Most Pseudomonas isolates were P. aeruginosa with a high rate of resistance (95% to amoxicillin/clavulanate and trimethoprim/sulfamethoxazole, and <50% to the other antibiotics). Colistin remained the most effective drug tested. This study provided useful information of the local bacterial epidemiology hopefully permitting to establish a more effective empirical therapy, preventing the inappropriate use of antibacterial agents and possibly limiting the diffusion of antibacterial resistance.
authors.forename: Silvano
authors.initials: S
authors.lastname: Esposito
authors.forename: Renato
authors.initials: R
authors.lastname: Pascale
authors.forename: Isabella
authors.initials: I
authors.lastname: Esposito
authors.forename: Silvana
authors.initials: S
authors.lastname: Noviello
authors.forename: Enrico
authors.initials: E
authors.lastname: Russo
authors.forename: Giuseppe De
authors.initials: GD
authors.lastname: Simone
authors.forename: Matilde
authors.initials: M
authors.lastname: Vitolo
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Rega
authors.forename: Angelo
authors.initials: A
authors.lastname: Massari
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D006784:Hospitals, Teaching; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000453:epidemiology* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D001618:beta-Lactamases / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases
keywords: Antibiotic resistance,; Bacterial epidemiology,; Gram negative