title: Parameters associated with significant liver histological changes in patients with chronic hepatitis B.
abstract: This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent predictors of significant fibrosis (P = 0.002, P < 0.001, P = 0.001, P = 0.048, P < 0.001, and P = 0.001, resp.). AST, WBC, and HBV DNA were significantly correlated with advanced fibrosis in normal ALT patients (P < 0.001, P = 0.041, and P = 0.012, resp.) and age, ALB, GLOB, PLT, and PT in patients with abnormal ALT (P = 0.003, P < 0.001, P = 0.004, P < 0.001, and P = 0.002, resp.). Age, AST, GGT, PLT, and PT were significantly associated with advanced fibrosis in HBeAg+ patients (P = 0.01, P = 0.016, P = 0.027, P = 0.016, and P = 0.009, resp.) and ALB, GLOB, WBC, PLT, and PT in HBeAg- patients (P < 0.001, P = 0.004, P = 0.005, P < 0.001, and P = 0.035, resp.). PLT was an excellent predictor for cirrhosis (P < 0.001 and AUROC = 0.805). ALT was not predictive of advanced fibrosis for patients with HBeAg+ or HBeAg- (P = 0.273 and P = 0.599, resp.). PLT was an excellent predictor for cirrhosis in CHB patients. Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.
authors.affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.
authors.forename: Li
authors.identifier: 0000-0002-3105-4488
authors.initials: L
authors.lastname: Xiao
authors.affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.
authors.forename: Jianchun
authors.identifier: 0000-0003-0671-8489
authors.initials: J
authors.lastname: Xian
authors.affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.
authors.forename: Yang
authors.identifier: 0000-0003-4332-0605
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.
authors.forename: Aiwen
authors.identifier: 0000-0001-7150-5119
authors.initials: A
authors.lastname: Geng
authors.affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.
authors.forename: Xiuzhen
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.
authors.forename: Libin
authors.identifier: 0000-0001-6953-149X
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.
authors.forename: Hongtao
authors.identifier: 0000-0001-5468-8224
authors.initials: H
authors.lastname: Xu