title: Primary acute dengue and the deletion in chemokine receptor 5 (CCR5Δ32).
abstract: Dengue virus is a significant arboviral pathogen that is continuing to spread due to human travel and invasion of the mosquito vectors into new regions. Chemokine receptor 5 (CCR5) has a truncated 32 base pair deletion form (CCR5Δ32), which has been associated with resistance to HIV but increased severity in some flaviviral diseases. If CCR5Δ32 is associated with dengue, European carriers of this mutation may be at increased risk. In a Western Australian population with the same frequency of CCR5Δ32 (0.08) as that found in southern Europe there was no significant difference in CCR5Δ32 allele frequency between returned travellers with and without dengue (p = 0.82, OR = 0.86, 95% CI = 0.35-2.1).
authors.affiliation: School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia. Electronic address: B.Brestovac@curtin.edu.au.
authors.forename: Brian
authors.initials: B
authors.lastname: Brestovac
authors.affiliation: School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia.
authors.forename: Larissa A
authors.initials: LA
authors.lastname: Halicki
authors.affiliation: School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia.
authors.forename: Ryan P
authors.initials: RP
authors.lastname: Harris
authors.affiliation: Department of Microbiology, Pathwest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia.
authors.forename: Ian
authors.initials: I
authors.lastname: Sampson
authors.affiliation: Department of Microbiology, Pathwest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia; School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia 6009, Australia.
authors.forename: David J
authors.initials: DJ
authors.lastname: Speers
authors.affiliation: School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia.
authors.forename: Cyril
authors.initials: C
authors.lastname: Mamotte
authors.affiliation: School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia; Department of Microbiology, Pathwest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Williams
mesh_terms: D000208:Acute Disease; D016022:Case-Control Studies; D003715:Dengue / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D019713:Receptors, CCR5 / Q000235:genetics*; D017384:Sequence Deletion; D014904:Western Australia
chemical_list: D019713:Receptors, CCR5
keywords: Cysteine–cysteine chemokine receptor 5 (CCR5); Cysteine–cysteine chemokine receptor 5–32 base deletion (CCR5Δ32); Dengue virus (DENV); Flavivirus; Vector