title: Antioxidant potential and oxidative DNA damage preventive activity of unexplored endemic species of Curcuma.
abstract: Free radical scavenging activity, ferrous ion chelating capacity, reducing power and genoprotective effect of the aqueous leaf extracts of four unexplored endemic Curcuma spp. (C. vamana, C. neilgherrensis, C. mutabilis, C. haritha) were found to be dose-dependent and were highest in C. vamana. DNA protection property of the extracts was evaluated against H202/UV-induced oxidative damage. DNA-methyl green displacement assay showed that these extracts were free of DNA intercalating compounds. Further, hemolysis assay also showed that the extracts were non-toxic to human erythrocytes. The results highlight C. vamana as a promising source for herbal preparations possessing high antioxidant potential and genoprotective activity.
authors.affiliation: Department of Biotechnology, University of Calicut, Malappuram 673635, India.
authors.forename: Iyyappan
authors.initials: I
authors.lastname: Rajan
authors.affiliation: Department of Biotechnology, University of Calicut, Malappuram 673635, India.
authors.forename: Remitha
authors.initials: R
authors.lastname: Rabindran
authors.affiliation: Department of Biotechnology, University of Calicut, Malappuram 673635, India.
authors.forename: P R
authors.initials: PR
authors.lastname: Jayasree
authors.affiliation: Department of Biotechnology, University of Calicut, Malappuram 673635, India.
authors.forename: P R M
authors.initials: PR
authors.lastname: Kumar
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D030024:Curcuma / Q000737:chemistry*; D004249:DNA Damage / Q000187:drug effects; D018744:DNA, Plant / Q000187:drug effects*; D016166:Free Radical Scavengers / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007502:Iron Chelating Agents / Q000378:metabolism / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D016839:Physarum polycephalum / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000975:Antioxidants; D018744:DNA, Plant; D016166:Free Radical Scavengers; D007502:Iron Chelating Agents; D010936:Plant Extracts