title: Emergence of G186D mutation in the presence of R292K mutation in an immunocompromised child infected with influenza A/H3N2 virus, treated with oseltamivir.
abstract: An immunocompromised child with influenza A/H3N2 virus infection, treated with oseltamivir from day 1, had nasal swabs taken on days 1, 4, 7, and 10 of the illness. Pyrosequencing showed increasing proportions of viruses with R292K (neuraminidase gene) and G186D (hemagglutinin gene) mutations, resulting in a viral load rebound by day 10.
authors.affiliation: Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Hong Kai
authors.initials: HK
authors.lastname: Lee
authors.forename: Julian Wei-Tze
authors.initials: JW
authors.lastname: Tang
authors.forename: Tze Ping
authors.initials: TP
authors.lastname: Loh
authors.forename: Debra Han-Lin
authors.initials: DH
authors.lastname: Kong
authors.forename: Yew-Weng
authors.initials: YW
authors.lastname: Lau
authors.forename: Hui Kim
authors.initials: HK
authors.lastname: Yap
authors.forename: Evelyn Siew-Chuan
authors.initials: ES
authors.lastname: Koay
mesh_terms: D002648:Child; D005260:Female; D005814:Genes, Viral / Q000235:genetics*; D006801:Humans; D016867:Immunocompromised Host / Q000187:drug effects; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects* / Q000235:genetics*; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology*; D009154:Mutation / Q000235:genetics*; D053139:Oseltamivir / Q000627:therapeutic use*; D019562:Viral Load / Q000235:genetics
chemical_list: D053139:Oseltamivir