title: Changes in bone mineral density of both proximal femurs after total knee arthroplasty.
abstract: BACKGROUND
  This study investigated the effects of total knee arthroplasty (TKA) on bone mineral density (BMD) of the proximal femur in patients who underwent the procedure.
  
  
  METHODS
  Forty-eight patients scheduled to undergo unilateral TKA because of primary knee osteoarthritis were included in this study, which was conducted at a medical center between October 2006 and October 2009. In these 48 patients, 96 hips were evaluated. Measurement of BMD was performed preoperatively and one month, three months, six months, and one year after unilateral TKA. Repeated measured analysis of variance and paired t-tests for comparison of two repeated samples were used to compare differences between time points (preoperation, one, three, six, and 12 months) and between the operative and nonoperative sides.
  
  
  RESULTS
  Preoperatively, BMD of the femoral neck, trochanter, and total hip on the operative side were lower than on the nonoperative side; however, there was no statistical difference. BMD of both femoral neck areas was significantly lower than preoperative BMD at one month and three months after TKA. BMD of both trochanter areas was significantly lower than preoperative BMD at one month and three months after TKA. BMD of both total hips was significantly lower than preoperative BMD at three months after TKA. However, no statistical differences of changes in BMD were observed between the operative and nonoperative sides at each measurement time.
  
  
  CONCLUSIONS
  According to our results, TKA was found to affect both proximal femurs during the acute period. However, TKA did not affect a change in BMD of the proximal femur during one year postoperative.
authors.affiliation: Department of Orthopedic Surgery, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Kwang Kyoun
authors.initials: KK
authors.lastname: Kim
authors.affiliation: Department of Orthopedic Surgery, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Ye Yeon
authors.initials: YY
authors.lastname: Won
authors.affiliation: Department of Orthopedic Surgery, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Youn Moo
authors.initials: YM
authors.lastname: Heo
authors.affiliation: Department of Orthopedic Surgery, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Dae Hee
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Orthopedic Surgery, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Jeong Yong
authors.initials: JY
authors.lastname: Yoon
authors.affiliation: Department of Orthopedic Surgery, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Won Sub
authors.initials: WS
authors.lastname: Sung
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D015519:Bone Density / Q000502:physiology*; D005260:Female; D005272:Femur Neck / Q000503:physiopathology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: Bone mineral density; Proximal hip; Total knee arthroplasty