title: Analysis of socket preservation using polylactide and polyglycolide (PLA-PGA) sponge: a clinical, radiographic, and histologic study.
abstract: The aim of this study was to evaluate the extraction socket healing and dimensional changes following alveolar ridge preservation using polylactide and polyglycolide (PLA-PGA) sponge. Fifteen patients were selected for alveolar socket preservation immediately following tooth extraction. Monoradicular maxillary and mandibular teeth were evaluated. The selected sockets had intact sockets walls with a minimum of 7 mm of residual alveolar bone height. The test sites were thoroughly debrided and grafted with PLA-PGA sponge, while the control sites underwent natural healing. Computed tomography (CT) measurements were taken at baseline and 6 months. After 6 months of healing, final CT measurements were performed, and trephine core biopsy specimens were obtained for histologic analysis. Implants were placed immediately after biopsy harvesting. All subjects completed the study, and all sites healed without adverse events and allowed for implant placement. The mean difference in socket height, width, and density after 6 months was statistically significantly higher in the test sites compared with control sites. Clinical measurement at the midbuccal site of the alveolar socket showed a mean loss of 2.45 ± 0.67 mm in the control group, compared with a mean gain of 1.28 ± 0.58 mm in the test group. All test sites showed minimal ridge alterations, and statistically significant differences were observed between the test and control sites with respect to bone composition and horizontal and vertical bone loss, indicating that PLA-PGA sponge is suitable for alveolar ridge preservation.
authors.forename: Rohit
authors.initials: R
authors.lastname: Madan
authors.forename: Ranjana
authors.initials: R
authors.lastname: Mohan
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Bains
authors.forename: Vivek
authors.initials: V
authors.lastname: Gupta
authors.forename: G P
authors.initials: GP
authors.lastname: Singh
authors.forename: Mani
authors.initials: M
authors.lastname: Madan
mesh_terms: D000328:Adult; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001706:Biopsy; D005260:Female; D006801:Humans; D057893:Immediate Dental Implant Loading; D008297:Male; D008875:Middle Aged; D011091:Polyesters / Q000627:therapeutic use*; D011100:Polyglycolic Acid / Q000627:therapeutic use*; D011161:Porifera; D014057:Tomography, X-Ray Computed; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery*; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D011091:Polyesters; D011100:Polyglycolic Acid; C033616:poly(lactide)