title: The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys.
abstract: BACKGROUND
  Boswellia serrata has been used in a wide variety of diseases, including diabetes mellitus and inflammatory diseases.
  
  
  OBJECTIVE
  This study focused on the effects of Boswellia serrata aqueous extract on blood glucose and the complications of diabetes in the liver and kidneys and examined the impact of plant on reproduction in diabetic rats.
  
  
  METHODS
  The antioxidant capacity of plant extract was performed using FRAP assay. Diabetic and control rats were administered 200, 400, and 600 mg/kg Boswellia serrata extract. Vaginal plaque was mentioned as a positive sign of pregnancy ;and treatment started with extract or vehicle from 1th to 17th day of gestation by gastric gavage. Blood glucose was measured during 17 days.
  
  
  RESULTS
  The Administration of Boswellia serrata in diabetic rats significantly decreased the level of blood glucose and HbA1c after 17th days (P ≤ 0.01). In diabetic group that received no treatment, the abortion of fetus spontaneous was 19.14%. The percentage of absorptions significantly was elevated in vehicle-treated diabetic rats, in comparison with vehicle- treated healthy rats. In the diabetic group, separated necrosis of hepatocytes, anarchism of liver plates, and lymphocytic inflammation were improved. Diabetic complications were not seen and the severity of damage was reduced. These damages include: lymphocytic inflammation in the port areas, irregularities, apoptosis of liver cells, and dilatation of the sinusoids.
  
  
  CONCLUSIONS
  The results suggest that Boswellia serrata extract has the antidiabetic effects and can prevent the complications of diabetes in the kidneys and liver.
authors.affiliation: Medicinal Plant Research Center, Department of Pharmacognosy, School of pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors.forename: Mohamad Ebrahim
authors.initials: ME
authors.lastname: Azemi
authors.affiliation: Medicinal Plant Research Center, Department of Pharmacognosy, School of pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran ; Marine Pharmaceutical Research Center, Pharmacognosy Department, School of pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors.forename: Foroogh
authors.initials: F
authors.lastname: Namjoyan
authors.affiliation: Toxicology Research Center, Department of Toxicology-Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Khodayar
authors.affiliation: School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors.forename: Forouzan
authors.initials: F
authors.lastname: Ahmadpour
authors.affiliation: School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors.forename: Azam
authors.initials: A
authors.lastname: Darvish Padok
authors.affiliation: Department of Anatomy, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors.forename: Marziyeh
authors.initials: M
authors.lastname: Panahi
keywords: Antioxidants; Boswellia; Diabetes Complications; Histology; Hypoglycemic Agents; Rats