title: MicroRNA-23b is an independent prognostic marker and suppresses ovarian cancer progression by targeting runt-related transcription factor-2.
abstract: Our previous study found that runt-related transcription factor-2 (RUNX2) was upregulated in human epithelial ovarian cancer (EOC) tissues and may be involved in tumor progression and prognosis. The aim of this study was to investigate the mechanism by which RUNX2 is aberrantly expressed in EOC. We firstly confirmed that miRNA-23b directly targets RUNX2 in EOC. Then, ectopic expression of miR-23b significantly inhibited ovarian cancer cell proliferation and tumorigenicity by regulating the expression of RUNX2. Furthermore, the down-regulation of miR-23b was significantly correlated with tumor aggressiveness and poor prognosis of patients with EOC. Collectively, miR-23b may function as tumor suppressor through inhibiting the upregulation of RUNX2, and may be a potential prognostic marker for EOC.
authors.affiliation: Department of Gynaecology and Obstetrics, General Hospital of PLA, Beijing 100853, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Li
authors.affiliation: Medical School of PLA, Beijing 100853, China.
authors.forename: Zhongyu
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Medical School of PLA, Beijing 100853, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Gynaecology and Obstetrics, 477 Hospital of PLA, Xiangyang 441003, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Gynaecology and Obstetrics, General Hospital of PLA, Beijing 100853, China. Electronic address: yqyao@126.com.
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Yao
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D050659:Core Binding Factor Alpha 1 Subunit / Q000235:genetics* / Q000378:metabolism; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D053208:Kaplan-Meier Estimate; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D015999:Multivariate Analysis; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models; D034622:RNA Interference
chemical_list: D050659:Core Binding Factor Alpha 1 Subunit; C552430:MIRN23a microRNA, human; D035683:MicroRNAs; C493709:RUNX2 protein, human
keywords: Clinicopathological feature; Epithelial ovarian cancer; MicroRNA-23b; Overall survival; Progression-free survival; Runt-related transcription factor-2