title: Genome-scale acetylation-dependent histone eviction during spermatogenesis.
abstract: A genome-wide histone hyperacetylation is known to occur in the absence of transcription in haploid male germ cells, spermatids, before and during the global histone eviction and their replacement by non-histone DNA-packaging proteins. Although the occurrence of this histone hyperacetylation has been correlated with histone removal for a long time, the underlying mechanisms have remained largely obscure. Important recent discoveries have not only shed light on how histone acetylation could drive a subsequent transformation in genome organization but also revealed that the associated nucleosome dismantlement is a multi-step process, requiring the contribution of histone variants, critical destabilizing histone modifications and chromatin readers, including Brdt, working together to achieve the full packaging of the male genome, indispensable for the propagation of life.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U823 and Université Grenoble Alpes Institut Albert Bonniot, Grenoble F-38700, France.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Goudarzi
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U823 and Université Grenoble Alpes Institut Albert Bonniot, Grenoble F-38700, France.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shiota
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U823 and Université Grenoble Alpes Institut Albert Bonniot, Grenoble F-38700, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Rousseaux
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U823 and Université Grenoble Alpes Institut Albert Bonniot, Grenoble F-38700, France. Electronic address: khochbin@ujf-grenoble.fr.
authors.forename: Saadi
authors.initials: S
authors.lastname: Khochbin
mesh_terms: D000107:Acetylation; D000818:Animals; D016678:Genome; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008957:Models, Genetic; D009707:Nucleosomes / Q000235:genetics* / Q000378:metabolism*; D013091:Spermatogenesis
chemical_list: D006657:Histones; D009707:Nucleosomes
keywords: BET bromodomain; Brdt; acetylation; histone eviction; histone variants