title: Autopsy findings in fatal dengue haemorrhagic fever - 06 Cases.
abstract: BACKGROUND
  During recent outbreak of dengue fever in Delhi, there has been a significant increase in dengue-associated admission in hospitals. To better understand the pathology of dengue haemorrhagic fever, we conducted autopsies of dengue infections deaths within our hospital.
  
  
  METHODS
  This was an autopsy study of dengue-associated deaths at a large tertiary care hospital.
  
  
  RESULTS
  From Sep 2009 to Dec 2010, a total of 1032 patients with serological evidence of dengue infection were admitted to our hospital. There were twelve deaths and autopsies were conducted in six. Adult respiratory distress syndrome, bleeding diathesis, hypotension, hepatic failure and acute renal failure were the common causes of death despite early hospitalization, intravenous fluid, and blood-product support.
  
  
  CONCLUSIONS
  Dengue is associated with severe disease, and deaths do occur despite current supportive management. Early predictors of disease severity and better clinical interventions are needed.
authors.affiliation: Senior Advisor (Path & Neuropath), Base Hospital, Delhi Cantt 10, India.
authors.forename: K R
authors.initials: KR
authors.lastname: Rathi
authors.affiliation: Brig (Med), HQ 11 Corps, C/O 56 APO, India.
authors.forename: M M
authors.initials: MM
authors.lastname: Arora
authors.affiliation: Senior Advisor (Path & Oncopath), Base Hospital, Delhi Cantt 10, India.
authors.forename: K
authors.initials: K
authors.lastname: Sahai
authors.affiliation: Senior Advisor (Pathology), MH Kirkee, Pune 411020, India.
authors.forename: S
authors.initials: S
authors.lastname: Tripathi
authors.affiliation: Classified Specialist (Pathology & Micro), 7 Air Force Hosp, Kanpur, India.
authors.forename: S P
authors.initials: SP
authors.lastname: Singh
authors.affiliation: Classified Specialist (Pathology), AFTC Delhi Cantt 10, India.
authors.forename: D K
authors.initials: DK
authors.lastname: Raman
authors.affiliation: Graded Specialist (Pathology & Micro), INHS Ashvini, Colaba, Mumbai, India.
authors.forename: K B
authors.initials: KB
authors.lastname: Anand
keywords: Autopsy; Dengue haemorrhagic fever; Pathophysiology