title: Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine.
abstract: The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that vaccine efficacy is lower in the obese than in the non-obese. Here, we examined the influence of obesity on the efficacy of influenza vaccination using high fat diet (HFD) and regular fat diet (RFD) mice that were immunized with 2 types of influenza virus vaccines-cell culture-based vaccines and egg-based vaccines. HFD mice showed lower levels of neutralizing antibody titers as compared with RFD mice. Moreover, HFD mice showed high levels of MCP-1 in serum and adipocytes, and low level of influenza virus-specific effector memory CD8(+) T cells. After challenge with influenza virus, the lungs of HFD mice showed more severe inflammatory responses as compared with the lungs of RFD mice, even after vaccination. Taken together, our data suggested that the inflammatory condition in obesity may contribute to the suppressed efficacy of influenza vaccination.
authors.affiliation: Department of Biotechnology; The Catholic University of Korea; Gyeonggi-do, South Korea.
authors.forename: Hye-Lim
authors.initials: HL
authors.lastname: Park
authors.affiliation: Department of Biotechnology; The Catholic University of Korea; Gyeonggi-do, South Korea.
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Shim
authors.affiliation: Department of Biotechnology; The Catholic University of Korea; Gyeonggi-do, South Korea.
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Lee
authors.affiliation: Department of Biotechnology; The Catholic University of Korea; Gyeonggi-do, South Korea.
authors.forename: Whajung
authors.initials: W
authors.lastname: Cho
authors.affiliation: Department of Biotechnology; The Catholic University of Korea; Gyeonggi-do, South Korea.
authors.forename: Sooho
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Biotechnology; The Catholic University of Korea; Gyeonggi-do, South Korea.
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Jeon
authors.affiliation: Department of Biotechnology; The Catholic University of Korea; Gyeonggi-do, South Korea.
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Ahn
authors.affiliation: SK Chemical; Sampyeong-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, South Korea.
authors.forename: Hun
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Biotechnology; The Catholic University of Korea; Gyeonggi-do, South Korea.
authors.forename: Jae-Hwan
authors.initials: JH
authors.lastname: Nam
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018932:Chemokine CCL2 / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects; D007249:Inflammation / Q000097:blood / Q000209:etiology / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: C491768:Ccl2 protein, mouse; D018932:Chemokine CCL2; D007252:Influenza Vaccines
keywords: high fat diet; inflammation; influenza virus; obesity; vaccine