title: When apperceptive agnosia is explained by a deficit of primary visual processing.
abstract: Visual agnosia is a deficit in shape perception, affecting figure, object, face and letter recognition. Agnosia is usually attributed to lesions to high-order modules of the visual system, which combine visual cues to represent the shape of objects. However, most of previously reported agnosia cases presented visual field (VF) defects and poor primary visual processing. The present case-study aims to verify whether form agnosia could be explained by a deficit in basic visual functions, rather that by a deficit in high-order shape recognition. Patient SDV suffered a bilateral lesion of the occipital cortex due to anoxia. When tested, he could navigate, interact with others, and was autonomous in daily life activities. However, he could not recognize objects from drawings and figures, read or recognize familiar faces. He was able to recognize objects by touch and people from their voice. Assessments of visual functions showed blindness at the centre of the VF, up to almost 5°, bilaterally, with better stimulus detection in the periphery. Colour and motion perception was preserved. Psychophysical experiments showed that SDV's visual recognition deficits were not explained by poor spatial acuity or by the crowding effect. Rather a severe deficit in line orientation processing might be a key mechanism explaining SDV's agnosia. Line orientation processing is a basic function of primary visual cortex neurons, necessary for detecting "edges" of visual stimuli to build up a "primal sketch" for object recognition. We propose, therefore, that some forms of visual agnosia may be explained by deficits in basic visual functions due to widespread lesions of the primary visual areas, affecting primary levels of visual processing.
authors.affiliation: CsrNC, Centro studi e ricerche in Neuroscienze Cognitive, Polo Scientifico-Didattico di Cesena, ALMA MATER STUDIORUM - Università di Bologna, Italy; Dipartimento di Psicologia, ALMA MATER STUDIORUM - Università di Bologna, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Serino
authors.affiliation: CsrNC, Centro studi e ricerche in Neuroscienze Cognitive, Polo Scientifico-Didattico di Cesena, ALMA MATER STUDIORUM - Università di Bologna, Italy; Dipartimento di Psicologia, ALMA MATER STUDIORUM - Università di Bologna, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cecere
authors.affiliation: CsrNC, Centro studi e ricerche in Neuroscienze Cognitive, Polo Scientifico-Didattico di Cesena, ALMA MATER STUDIORUM - Università di Bologna, Italy; Dipartimento di Psicologia, ALMA MATER STUDIORUM - Università di Bologna, Italy.
authors.forename: Neil
authors.initials: N
authors.lastname: Dundon
authors.affiliation: CsrNC, Centro studi e ricerche in Neuroscienze Cognitive, Polo Scientifico-Didattico di Cesena, ALMA MATER STUDIORUM - Università di Bologna, Italy; Dipartimento di Psicologia, ALMA MATER STUDIORUM - Università di Bologna, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Bertini
authors.affiliation: IRCCS, Fondazione Santa Lucia, Roma, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Sanchez-Castaneda
authors.affiliation: CsrNC, Centro studi e ricerche in Neuroscienze Cognitive, Polo Scientifico-Didattico di Cesena, ALMA MATER STUDIORUM - Università di Bologna, Italy; Dipartimento di Psicologia, ALMA MATER STUDIORUM - Università di Bologna, Italy. Electronic address: elisabetta.ladavas@unibo.it.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Làdavas
mesh_terms: D000328:Adult; D000377:Agnosia / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D003118:Color Perception / Q000502:physiology; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation; D011932:Reading; D014795:Visual Pathways / Q000473:pathology / Q000503:physiopathology*; D014796:Visual Perception / Q000502:physiology*
keywords: Cortical blindness; Crowding effect; Orientation discrimination deficit; Visual agnosia