title: Xanthoma disseminatum: a progressive case with multisystem involvement.
abstract: Xanthoma disseminatum (XD) is a rare, benign, non-Langerhans cell histiocytic disorder. The pathogenesis is not clear. It manifests with multiple, grouped, red-brown to yellow papules and nodules involving the skin, mucous membranes, and internal organs. We present a case of progressive XD in a 10-year-old male child. The patient presented with progressive, bilateral and symmetrical, reddish-brown, coalescent papules on the neck, around both eyes and all over his trunk and extremities. Skin lesions were accompanied by blurred vision and hoarseness of voice. Examination revealed xanthomatous infiltration of cornea, oral, pharyngeal, and laryngeal mucosae. The patient had diabetes insipidus that was diagnosed 2 years before the appearance of skin lesions. Medical treatment with corticosteroids (20 mg/day) and azathioprine (2 mg/kg/day) did not stop the disease progression.
authors.forename: A M
authors.initials: AM
authors.lastname: Attia
authors.affiliation: Department of Dermatology, Andrology and Sexually Transmitted Diseases, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt.
authors.forename: O A
authors.initials: OA
authors.lastname: Bakry
authors.forename: E E
authors.initials: EE
authors.lastname: Mohamed
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D001706:Biopsy; D002648:Child; D003919:Diabetes Insipidus / Q000150:complications* / Q000175:diagnosis; D005938:Glucocorticoids / Q000627:therapeutic use; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007828:Laryngoscopy; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D005938:Glucocorticoids; D011239:Prednisolone; D001379:Azathioprine