title: Clinical manifestations of bacteremia caused by Aeromonas species in southern Taiwan.
abstract: OBJECTIVE
  This study is conducted to investigate the clinical characteristics of patients with bacteremia caused by Aeromonas species.
  
  
  METHODS
  Patients with bacteremia caused by Aeromonas species during the period 2009 to 2013 were identified from a computerized database of a regional hospital in southern Taiwan. The medical records of these patients were retrospectively reviewed.
  
  
  RESULTS
  A total of 91 patients with bacteremia due to Aeromonas species were identified. In addition to 16 (17.6%) primary bacteremia, the most common source of secondary infection is peritonitis (n = 27, 29.7%), followed by biliary tract infection (n = 18, 19.8%), and SSTI (n = 12, 13.2%), pneumonia (n = 9, 9.9%), catheter-related bloodstream infection (n =  5, 5.5%), and genitourinary tract infection (n = 4, 4.4%). A. hydrophila (n = 35, 38.5%) was the most common pathogen, followed by A. veronii biovar sobria (n = 31, 34.1%), A. caviae (n = 14, 15.4%), and A. veronii biovar veronii (n = 9, 9.9%). Forty-three (47.3%) patients were classified as healthcare-associated infections (HCAI) causes by Aeromonas species, and patients with HCAI were more likely to have cancer, and receive immunosuppressant than patients with community-acquired bacteremia. The overall outcomes, including rate of ICU admission, acute respiratory failure, and mortality were 33.3%, 28.6%, and 23.1%, respectively. Multivariate analysis showed that the in-hospital day mortality was significantly associated only with underlying cancer (P <.001), and initial shock (P <.001).
  
  
  CONCLUSIONS
  Aeromonas species should be considered one of the causative pathogens of healthcare-associated bacteremia, especially in immunocompromised patients. In addition, it can be associated with high fatality. Cancer and initial shock were the poor prognostic factors.
authors.affiliation: Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
authors.forename: Hung-Jen
authors.initials: HJ
authors.lastname: Tang
authors.affiliation: Department of Intensive Care Medicine, and Chi Mei Medical Center, Liouying, Tainan, Taiwan.
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Lai
authors.affiliation: Department of Nursing, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
authors.forename: Hsin-Lan
authors.initials: HL
authors.lastname: Lin
authors.affiliation: Department of Intensive Care Medicine, and Chi Mei Medical Center, Liouying, Tainan, Taiwan; Department of Nursing, Min-Hwei College of Health Care Management, Tainan, Taiwan.
authors.forename: Chien-Ming
authors.initials: CM
authors.lastname: Chao
mesh_terms: D000293:Adolescent; D000328:Adult; D000333:Aeromonas / Q000502:physiology*; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000494:pharmacology; D016470:Bacteremia / Q000382:microbiology* / Q000401:mortality / Q000473:pathology*; D002648:Child; D017714:Community-Acquired Infections / Q000382:microbiology / Q000401:mortality / Q000473:pathology; D003428:Cross Infection / Q000382:microbiology / Q000401:mortality / Q000473:pathology; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology* / Q000401:mortality / Q000473:pathology*; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011379:Prognosis; D013624:Taiwan / Q000453:epidemiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents