title: Synthesis, antimicrobial and cytotoxic activities of pyrimidinyl benzoxazole, benzothiazole and benzimidazole.
abstract: A variety of pyrimidinyl benzoxazoles, benzothiazoles and benzimidazoles linked by thio, methylthio and amino moieties were prepared and studied their antimicrobial and cytotoxic activities. The compound pyrimidinyl bis methylthio benzimidazole 22 was a potent antimicrobial agent particularly against Staphylococcus aureus (29 mm, MIC 12.5 μg/mL) and Penicillium chrysogenum (38 mm, MIC 12.5 μg/mL). The amino linked pyrimidinyl bis benzothiazole 24 exhibited cytotoxic activity on A549 cells with IC50 value of 10.5 μM.
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: D
authors.initials: D
authors.lastname: Seenaiah
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: P Ramachandra
authors.initials: PR
authors.lastname: Reddy
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: G Mallikarjuna
authors.initials: GM
authors.lastname: Reddy
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: A
authors.initials: A
authors.lastname: Padmaja
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India. Electronic address: vkpuram2001@yahoo.com.
authors.forename: V
authors.initials: V
authors.lastname: Padmavathi
authors.affiliation: Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, Bangalore 560 012, Karnataka, India.
authors.forename: N Siva
authors.initials: NS
authors.lastname: Krishna
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D001583:Benzoxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010408:Penicillium chrysogenum / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001562:Benzimidazoles; D052160:Benzothiazoles; D001583:Benzoxazoles; C031000:benzimidazole; C005465:benzothiazole
keywords: Antimicrobial activity; Benzimidazole; Benzothiazole; Cytotoxic activity; Pyrimidinyl benzoxazole