title: Beamformer source analysis and connectivity on concurrent EEG and MEG data during voluntary movements.
abstract: Electroencephalography (EEG) and magnetoencephalography (MEG) are the two modalities for measuring neuronal dynamics at a millisecond temporal resolution. Different source analysis methods, to locate the dipoles in the brain from which these dynamics originate, have been readily applied to both modalities alone. However, direct comparisons and possible advantages of combining both modalities have rarely been assessed during voluntary movements using coherent source analysis. In the present study, the cortical and sub-cortical network of coherent sources at the finger tapping task frequency (2-4 Hz) and the modes of interaction within this network were analysed in 15 healthy subjects using a beamformer approach called the dynamic imaging of coherent sources (DICS) with subsequent source signal reconstruction and renormalized partial directed coherence analysis (RPDC). MEG and EEG data were recorded simultaneously allowing the comparison of each of the modalities separately to that of the combined approach. We found the identified network of coherent sources for the finger tapping task as described in earlier studies when using only the MEG or combined MEG+EEG whereas the EEG data alone failed to detect single sub-cortical sources. The signal-to-noise ratio (SNR) level of the coherent rhythmic activity at the tapping frequency in MEG and combined MEG+EEG data was significantly higher than EEG alone. The functional connectivity analysis revealed that the combined approach had more active connections compared to either of the modalities during the finger tapping (FT) task. These results indicate that MEG is superior in the detection of deep coherent sources and that the SNR seems to be more vital than the sensitivity to theoretical dipole orientation and the volume conduction effect in the case of EEG.
authors.affiliation: Department of Neurology, Christian-Albrechts-University, Kiel, Germany.
authors.forename: Muthuraman
authors.initials: M
authors.lastname: Muthuraman
authors.affiliation: Department of Neurology, Christian-Albrechts-University, Kiel, Germany.
authors.forename: Helge
authors.initials: H
authors.lastname: Hellriegel
authors.affiliation: Department of Neurology, Heinrich-Heine University, Dusseldorf, Germany.
authors.forename: Nienke
authors.initials: N
authors.lastname: Hoogenboom
authors.affiliation: Department of Neurology, Christian-Albrechts-University, Kiel, Germany; Institute for Circuit and System Theory, Christian-Albrechts-University, Kiel, Germany.
authors.forename: Abdul Rauf
authors.initials: AR
authors.lastname: Anwar
authors.affiliation: Department of Neurology, Christian-Albrechts-University, Kiel, Germany; Institute for Circuit and System Theory, Christian-Albrechts-University, Kiel, Germany.
authors.forename: Kidist Gebremariam
authors.initials: KG
authors.lastname: Mideksa
authors.affiliation: Department of Neurology, Heinrich-Heine University, Dusseldorf, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Krause
authors.affiliation: Department of Neurology, Heinrich-Heine University, Dusseldorf, Germany.
authors.forename: Alfons
authors.initials: A
authors.lastname: Schnitzler
authors.affiliation: Department of Neurology, Christian-Albrechts-University, Kiel, Germany.
authors.forename: Günther
authors.initials: G
authors.lastname: Deuschl
authors.affiliation: Department of Neurology, Christian-Albrechts-University, Kiel, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Raethjen
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004569:Electroencephalography; D005260:Female; D019416:Head Movements; D064368:Healthy Volunteers; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008959:Models, Neurological; D009068:Movement / Q000502:physiology*; D059629:Signal-To-Noise Ratio; D055815:Young Adult