title: Epilepsy surgery series: a study of 502 consecutive patients from a developing country.
abstract: Purpose. To review the postoperative seizure outcomes of patients that underwent surgery for epilepsy at King Faisal Specialist Hospital & Research Centre (KFSHRC). Methods. A descriptive retrospective study for 502 patients operated on for medically intractable epilepsy between 1998 and 2012. The surgical outcome was measured using the ILAE criteria. Results. The epilepsy surgery outcome for temporal lobe epilepsy surgery (ILAE classes 1, 2, and 3) at 12, 36, and 60 months is 79.6%, 74.2%, and 67%, respectively. The favorable 12- and 36-month outcomes for frontal lobe epilepsy surgery are 62% and 52%, respectively. For both parietal and occipital epilepsy lobe surgeries the 12- and 36-month outcomes are 67%. For multilobar epilepsy surgery, the 12- and 36-month outcomes are 65% and 50%, respectively. The 12- and 36-month outcomes for functional hemispherectomy epilepsy surgery are 64.2% and 63%, respectively. According to histopathology diagnosis, mesiotemporal sclerosis (MTS) and benign CNS tumors had the best favorable outcome after surgery at 1 year (77.27% and 84.3%, resp.,) and 3 years (76% and 75%, resp.,). The least favorable seizure-free outcome after 3 years occurred in cases with dual pathology (66.6%). Thirty-four epilepsy patients with normal magnetic resonance imaging (MRI) brain scans were surgically treated. The first- and third-year epilepsy surgery outcome of 17 temporal lobe surgeries were (53%) and (47%) seizure-free, respectively. The first- and third-year epilepsy surgery outcomes of 15 extratemporal epilepsy surgeries were (47%) and (33%) seizure-free. Conclusion. The best outcomes are achieved with temporal epilepsy surgery, mesial temporal sclerosis, and benign CNS tumor. The worst outcomes are from multilobar surgery, dual pathology, and normal MRI.
authors.affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia ; Neurology Section, Department of Neurosciences, King Faisal Specialist Hospital & Research Centre, MBC.76, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
authors.forename: Abdulaziz
authors.identifier: 0000-0002-4196-3239
authors.initials: A
authors.lastname: Alsemari
authors.affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
authors.forename: Faisal
authors.initials: F
authors.lastname: Al-Otaibi
authors.affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
authors.forename: Salah
authors.initials: S
authors.lastname: Baz
authors.affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Althubaiti
authors.affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
authors.forename: Hisham
authors.initials: H
authors.lastname: Aldhalaan
authors.affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
authors.forename: David
authors.initials: D
authors.lastname: Macdonald
authors.affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
authors.forename: Tareq
authors.initials: T
authors.lastname: Abalkhail
authors.affiliation: University of Minnesota Medical Center, Fairview, Epilepsy Care Center, Minnesota, MN 55455, USA.
authors.forename: Miguel E
authors.initials: ME
authors.lastname: Fiol
authors.affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
authors.forename: Suad
authors.initials: S
authors.lastname: Alyamani
authors.affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
authors.forename: Aziza
authors.initials: A
authors.lastname: Chedrawi
authors.affiliation: University of Calgary, AB, Canada T2N 1N4.
authors.forename: Frank
authors.initials: F
authors.lastname: Leblanc
authors.affiliation: London Health Science Center, London, ON, Canada N6G 2V4.
authors.forename: Andrew
authors.initials: A
authors.lastname: Parrent
authors.affiliation: Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
authors.forename: Donald
authors.initials: D
authors.lastname: Maclean
authors.affiliation: London Health Science Center, London, ON, Canada N6G 2V4.
authors.forename: John
authors.initials: J
authors.lastname: Girvin