title: Peripheral CD4+ cell prevalence and pleuropulmonary manifestations in systemic lupus erythematosus patients.
abstract: BACKGROUND
  Systemic lupus erythematosus (SLE) is an autoimmune disease involving several organs, including the lungs. Previous results confirmed changes of peripheral T cell subsets in lupus patients; however no data are available about their possible relationship with pulmonary involvement.
  
  
  OBJECTIVE
  To determine pulmonary manifestations and potential relationship in changes of peripheral CD4+ T cell subsets.
  
  
  METHODS
  Patients with SLE (N = 28) were enrolled in complex pulmonary examination. Patients were divided into groups with pleuropulmonary manifestations (SLEpulm N = 13 age: 44.9 ± 3.3 years, female: male = 11:2) or without (SLEc N = 15 age: 27.2 ± 3.7 years, female: male = 12:3). Peripheral blood was taken for T helper (Th)1, Th2, Th17, CD4+CD25hi+ and regulatory T (Treg: CD4+CD25hi+ CD127-) cell analysis from SLE patients and healthy volunteers (controls, N = 40).
  
  
  RESULTS
  SLEpulm patients were older, had more pulmonary symptoms and significantly decreased pO2 as compared to SLEc group. Ventilatory disorder was present in 92% of SLEpulm patients, with significantly decreased lung volumes, signs of airway involvement and decrease in DLco. Significant increase in Th1/Th2, while decrease in Th17/Treg ratios was present in all SLE compared to controls. In SLEpulm CD4+CD25hi+ subset without changes in Treg number was significantly increased as compared to SLEc and this subgroup of T cell showed significant positive correlation with dynamic lung function parameters and DLco (p < 0.05).
  
  
  CONCLUSIONS
  In lupus patients pleuropulmonary manifestations are prevalent and lung function and blood gas measurements should be regularly performed in the daily clinical assessment. Significant increase of activated CD4+CD25hi+ T cells, but not Treg is associated with decreased lung function parameters in SLEpulm patients.
authors.affiliation: Department of Pulmonology, Semmelweis University, Dios arok 1/c, Budapest 1125, Hungary.
authors.forename: Krisztina
authors.initials: K
authors.lastname: Vincze
authors.affiliation: Department of Pulmonology, Semmelweis University, Dios arok 1/c, Budapest 1125, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Kovats
authors.affiliation: I.st Department of Pediatrics, Semmelweis University, Bokay J u. 53, Budapest 1083, Hungary.
authors.forename: Aron
authors.initials: A
authors.lastname: Cseh
authors.affiliation: I.st Department of Pediatrics, Semmelweis University, Bokay J u. 53, Budapest 1083, Hungary.
authors.forename: Krisztina
authors.initials: K
authors.lastname: Pasti
authors.affiliation: National Institute of Rheumatology and Physicotherapy, Frankel Leo u. 25-29, Budapest 1023, Hungary.
authors.forename: Emese
authors.initials: E
authors.lastname: Kiss
authors.affiliation: National Institute of Rheumatology and Physicotherapy, Frankel Leo u. 25-29, Budapest 1023, Hungary.
authors.forename: Anna
authors.initials: A
authors.lastname: Polgar
authors.affiliation: I.st Department of Pediatrics, Semmelweis University, Bokay J u. 53, Budapest 1083, Hungary.
authors.forename: Barna
authors.initials: B
authors.lastname: Vasarhelyi
authors.affiliation: I.st Department of Pediatrics, Semmelweis University, Bokay J u. 53, Budapest 1083, Hungary.
authors.forename: Attila J
authors.initials: AJ
authors.lastname: Szabo
authors.affiliation: Department of Pulmonology, Semmelweis University, Dios arok 1/c, Budapest 1125, Hungary.
authors.forename: Aniko
authors.initials: A
authors.lastname: Bohacs
authors.affiliation: Department of Pulmonology, Semmelweis University, Dios arok 1/c, Budapest 1125, Hungary.
authors.forename: Lilla
authors.initials: L
authors.lastname: Tamasi
authors.affiliation: Department of Pulmonology, Semmelweis University, Dios arok 1/c, Budapest 1125, Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Losonczy
authors.affiliation: Department of Pulmonology, Semmelweis University, Dios arok 1/c, Budapest 1125, Hungary. Electronic address: mulver@pulm.sote.hu.
authors.forename: Veronika
authors.initials: V
authors.lastname: Müller
mesh_terms: D000293:Adolescent; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002245:Carbon Dioxide / Q000097:blood; D002648:Child; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008171:Lung Diseases / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D015656:Respiratory Mechanics / Q000502:physiology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D002245:Carbon Dioxide; D010100:Oxygen
keywords: CD4+CD25hi+; Lung; Lung function; Systemic lupus erythematosus; T cells