title: [The use of local hemostatic agent "Celox" in experimental model of grade IV liver injury].
abstract: Ongoing intra-abdominal bleeding is the main life-threatening sequence of blunt abdominal trauma. The use of local hemostatic agents allows achieving fast and reliable hemorrhage control in case of parenchymatous organs injury. We investigated the efficacy of a dressing "Celox Gauze" in an experimental model of grade IV liver injury in large animals in the setting of coagulopathy. We used the following experimental model: 30-35% of blood volume was withdrawn followed by severe liver injury and hemostatic agent application. Laboratory tests were controlled in three endpoints. Hemostasis was evaluated in 2 days. "Celox Gauze" was effective for hemorrhage control in 100% of cases. All animals survived until the end of the experiment. Perihepatic packing with "Celox Gauze" applied is more effective to control hemorrhage than packing only. It has been noted lower volume of blood loss, lower decrease of red blood cells in animals of "Celox Gauze" group. We noted no adverse effects. Histological analysis showed the absence of any significant local hepatic damage. In whole the local hemostatic agent "Celox Gauze" has been shown highly effective in the model of parenchymatous bleeding. Additional studies with more number of animals are warranted to confirm our results.
authors.forename: I M
authors.initials: IM
authors.lastname: Samokhvalov
authors.forename: K P
authors.initials: KP
authors.lastname: Golovko
authors.forename: V A
authors.initials: VA
authors.lastname: Reva
authors.forename: A V
authors.initials: AV
authors.lastname: Zhabin
authors.forename: A V
authors.initials: AV
authors.lastname: Denisov
authors.forename: M V
authors.initials: MV
authors.lastname: Sokhranov
authors.forename: M V
authors.initials: MV
authors.lastname: Kaznacheev
authors.forename: A B
authors.initials: AB
authors.lastname: Iudin
authors.forename: P G
authors.initials: PG
authors.lastname: Alisov
mesh_terms: D000818:Animals; D001704:Biopolymers / Q000494:pharmacology*; D004195:Disease Models, Animal; D004285:Dogs; D006470:Hemorrhage / Q000601:surgery*; D006490:Hemostatics / Q000494:pharmacology*; D008099:Liver / Q000293:injuries* / Q000601:surgery*; D014949:Wounds, Nonpenetrating / Q000601:surgery*
chemical_list: D001704:Biopolymers; C540163:Celox; D006490:Hemostatics