title: Supplementation and therapeutic use of vitamin D in patients with multiple sclerosis: consensus of the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology.
abstract: Multiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating, and degenerative central nervous system disease. Even though the etiology of MS has not yet been fully elucidated, there is evidence that genetic and environmental factors interact to cause the disease. Among the main environmental factors studied, those more likely associated with MS include certain viruses, smoking, and hypovitaminosis D. This review aimed to determine whether there is evidence to recommend the use of vitamin D as monotherapy or as adjunct therapy in patients with MS. We searched PUBMED, EMBASE, COCHRANNE, and LILACS databases for studies published until September 9 th , 2013, using the keywords "multiple sclerosis", "vitamin D", and "clinical trial". There is no scientific evidence up to the production of this consensus for the use of vitamin D as monotherapy for MS in clinical practice.
authors.affiliation: Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, BotucatuSP, Brazil, Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu SP, Brazil;
authors.forename: Doralina Guimarães
authors.initials: DG
authors.lastname: Brum
authors.affiliation: Hospital das Clínicas, Universidade Federal de Minas Gerai, Belo HorizonteMG, Brazil, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte MG, Brazil;
authors.forename: Elizabeth Regina
authors.initials: ER
authors.lastname: Comini-Frota
authors.affiliation: Universidade Federal do Rio de Janeiro, Rio de JaneiroRJ, Brazil, Universidade Federal do Rio de Janeiro, Rio de Janeiro RJ, Brazil;
authors.forename: Claúdia Cristina F
authors.initials: CC
authors.lastname: Vasconcelos
authors.affiliation: Hospital de Base do Distrito Federa, BrasíliaDF, Brazil, Hospital de Base do Distrito Federal, Brasília DF, Brazil.
authors.forename: Elza
authors.initials: E
authors.lastname: Dias-Tosta
mesh_terms: D002986:Clinical Trials as Topic; D019587:Dietary Supplements; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy*; D014807:Vitamin D / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D014815:Vitamins; D014807:Vitamin D