title: Aberrant resting-state functional connectivity in a genetic rat model of depression.
abstract: Abnormal intrinsic functional connectivity, measured by resting-state functional MRI, has been reported in major depressive disorder (MDD). Our study is the first to demonstrate hypo- and hyperconnectivity between the hippocampus and cortical, subcortical regions in a genetic animal model of depression, similar to connectivity anomalies found in MDD.
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Williams
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; The Norman and Helen Asher Center for the Study of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Neha S
authors.initials: NS
authors.lastname: Mehta
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; The Norman and Helen Asher Center for the Study of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: e-redei@northwestern.edu.
authors.forename: Eva E
authors.initials: EE
authors.lastname: Redei
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Procissi
mesh_terms: D000818:Animals; D003863:Depression / Q000503:physiopathology*; D003865:Major Depressive Disorder / Q000235:genetics / Q000503:physiopathology*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008957:Models, Genetic; D009415:Nerve Net / Q000503:physiopathology*; D051381:Rats; D011921:Rats, Inbred WKY; D012146:Rest / Q000502:physiology
keywords: Functional MRI; Hippocampus; Wistar Kyoto More Immobile