title: [Preparation and anti-breast cancer activity of (-)-antofine carried with liposomes].
abstract: OBJECTIVE
  To prepare (-)-Antofine liposomes with high activity and good water-soluble and study its anti-breast cancer activity both in vitro and in vivo.
  
  
  METHODS
  (-)-Antofine liposomes were prepared by film dispersion method, the encapsulation efficiency of (-)-Antofine liposomes were determined by UV spectrophotometer, the cytotoxic activity of (-)-Antofine liposomes on MCF-7 cell was measured by MTT assay, the antitumor activity and major organs indexes were evaluated by tumor-bearing nude mice experimental in vivo.
  
  
  RESULTS
  The average encapsulation efficiency of (-)-Antofine liposomes was (80.8 +/- 2.2)%, average drug loading was (26.7 +/- 1.4)%, it was relatively good water-soluble and had good anti-tumor activity in vitro and in vivo.
  
  
  CONCLUSIONS
  (-)-Antofine liposomes prepared by film dispersion method has high encapsulation efficiency, the water-soluble and the anti-tumor activity are improved compared with (-)-Antofine.
authors.forename: Duo-Ming
authors.initials: DM
authors.lastname: Wu
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Wu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology*; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D008081:Liposomes / Q000737:chemistry*; D061986:MCF-7 Cells; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles; D010316:Particle Size; D010618:Phenanthrolines / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D012995:Solubility; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D007211:Indoles; D008081:Liposomes; D010618:Phenanthrolines; C473343:antofine