title: Role of interleukin-22 in liver diseases.
abstract: BACKGROUND
  Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly expressed by Th17 cells and is tightly linked to chronic inflammation, including inflammatory bowel disease and local intestinal inflammation among others.
  
  
  METHODS
  A PubMed and Web of Science databases search was performed for studies providing evidences on the role of IL-22 in liver diseases.
  
  
  CONCLUSIONS
  IL-22 plays an important role in ameliorating liver injury in many rodent models by targeting hepatocytes that express high levels of IL-22 receptor 1 and IL-10 receptor 2. This review concisely summarizes the role of IL-22 in the development progression of liver disease of different etiologies. It is focused mainly on the IL-22 intracellular signaling and its influence on liver diseases.
authors.affiliation: School of Pharmacy, Anhui Medical University, 81 Mei-shan Road, Hefei, 230032, China.
authors.forename: Chun-xiao
authors.initials: CX
authors.lastname: Pan
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.forename: Xiao-yu
authors.initials: XY
authors.lastname: Wang
authors.forename: Fan-rong
authors.initials: FR
authors.lastname: Wu
authors.forename: Jin-fang
authors.initials: JF
authors.lastname: Ge
authors.forename: Fei-hu
authors.initials: FH
authors.lastname: Chen
mesh_terms: D000818:Animals; D006801:Humans; D007378:Interleukins / Q000378:metabolism* / Q000627:therapeutic use; D008107:Liver Diseases / Q000188:drug therapy / Q000378:metabolism*; D018123:Receptors, Interleukin / Q000378:metabolism; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D018123:Receptors, Interleukin; D000097043:Interleukin-22; C415369:interleukin-22 receptor