title: Base-catalyzed N-N bond cleavage of hydrazones: synthesis of α-amino ketones.
abstract: An efficient Cs2CO3-promoted synthesis of α-amino ketones using hydrazines, aldehydes, and α-haloketones as starting materials through a cascade condensation/nucleophilic substitution/N-N bond cleavage route is developed. The carbonyl group plays a key role in this novel N-N bond cleavage process.
authors.affiliation: Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian (People's Republic of China), Fax: (+86) 592-218-0318.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Tang
authors.forename: Yun-Bing
authors.initials: YB
authors.lastname: Zhou
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.forename: Hong-Chao
authors.initials: HC
authors.lastname: Sun
authors.forename: Min
authors.initials: M
authors.lastname: Lin
authors.forename: Zhuang-Ping
authors.initials: ZP
authors.lastname: Zhan
mesh_terms: D002384:Catalysis; D006835:Hydrazones / Q000737:chemistry*; D006860:Hydrogen Bonding; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D006835:Hydrazones; D007659:Ketones
keywords: NN bond cleavage; amino ketones; domino reactions; hydrazones