title: New experimental protocols for tensile testing of abdominal aortic analogues.
abstract: This work proposes an in vitro tensile testing protocol that is able to characterize abdominal aortic (AA) analogues under physiologically inspired mechanical loadings. Kinematic parameters are defined in agreement with in vivo measurements of aortic dynamics. A specific focus is given to the choice of the applied loading rates, deriving from the knowledge of aortic Peterson modulus and blood pressure variations from diastolic to systolic instants. The influence of physiological elongation rates has been tested on both porcine AAs and a thermoplastic polyurethane (TPU) material used to elaborate AA analogues. The diastolic and systolic elongation rates estimates vary between orders of magnitude O(10(-2)) and O(10(-1))s(-1). Negligible differences are obtained when comparing stress-elongation responses between both physiological elongation rates. In contrast, a noticeable stiffening of the TPU mechanical response is observed compared to that obtained under the common low traction rate of O(10(-3))s(-1). This work shows how relevant physiological elongation rates can be evaluated as a function of age, gender and pathological context.
authors.affiliation: Aix Marseille Université, CNRS, Centrale Marseille, IRPHE UMR 7342, 13384 Marseille, France. Electronic address: lucie.bailly@irphe.univ-mrs.fr.
authors.forename: L
authors.initials: L
authors.lastname: Bailly
authors.affiliation: Aix Marseille Université, CNRS, Centrale Marseille, IRPHE UMR 7342, 13384 Marseille, France.
authors.forename: V
authors.initials: V
authors.lastname: Deplano
authors.affiliation: Aix Marseille Université, CNRS, Centrale Marseille, IRPHE UMR 7342, 13384 Marseille, France; Univ. Grenoble Alpes, 3SR, F-38000 Grenoble, France; CNRS, 3SR, F-38000 Grenoble, France; MDB Texinov, 38354, La Tour du Pin, France.
authors.forename: A
authors.initials: A
authors.lastname: Lemercier
authors.affiliation: Aix Marseille Université, CNRS, Centrale Marseille, IRPHE UMR 7342, 13384 Marseille, France.
authors.forename: O
authors.initials: O
authors.lastname: Boiron
authors.affiliation: Aix Marseille Université, CNRS, Centrale Marseille, IRPHE UMR 7342, 13384 Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Meyer
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001012:Aorta, Abdominal / Q000502:physiology*; D001696:Biomechanical Phenomena; D040761:Biomimetic Materials; D001794:Blood Pressure / Q000502:physiology; D001807:Blood Vessel Prosthesis; D004548:Elasticity; D006801:Humans; D008297:Male; D008422:Materials Testing / Q000379:methods*; D008875:Middle Aged; D011140:Polyurethanes; D013314:Stress, Mechanical; D013552:Swine; D013718:Tensile Strength
chemical_list: D011140:Polyurethanes
keywords: Arterial analogue; Elongation rates; Experimental protocols; Physiological loadings; Porcine aortic tissue; Uniaxial tensile tests