title: Effect of Bifidobacterium animalis on mice infected with Strongyloides venezuelensis.
abstract: The administration of viable Bifidobacterium animalis was tested to induce resistance against Strongyloides venezuelensis infection in mice. Effects on parasite burden, worm length, egg output, and intestinal mucosal histology were evaluated. The oral administration of B. animalis, strain 04450B, starting 14 days before the inoculation of nematode larvae significantly decreased the worm burden and egg output. In probiotic treated animals, the percent reduction of adult worms in the intestine was of 33% and the reduction of egg production was of 21%, compared with those of the control group. The duodenum villous height and villous/crypt ratio were significantly higher in probiotic-treated mice, indicating that this group could be experiencing less intestinal damage. The present findings revealed that the administration of B. animalis for the amelioration of host response to nematode infections is biologically plausible and could have some potential for impacting public health. Meanwhile, further study is needed to delineate the nature and identity of the factor(s) involved in these beneficial effects.
authors.affiliation: Parasitology Department, Institute of Bioscience, São Paulo State University (UNESP), 18618-000BotucatuSP, Brazil, Parasitology Department, Institute of Bioscience, São Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil.
authors.forename: Teresa Cristina Goulart
authors.initials: TC
authors.lastname: Oliveira-Sequeira
authors.affiliation: Parasitology Department, Institute of Bioscience, São Paulo State University (UNESP), 18618-000BotucatuSP, Brazil, Parasitology Department, Institute of Bioscience, São Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil.
authors.forename: Érica Boarato
authors.initials: ÉB
authors.lastname: David
authors.affiliation: College of Veterinary Medicine and Animal Science (FMVZ), São Paulo State University (UNESP), 18618-000BotucatuSP, Brazil, College of Veterinary Medicine and Animal Science (FMVZ), São Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil.
authors.forename: Cláudia
authors.initials: C
authors.lastname: Ribeiro
authors.affiliation: Parasitology Department, Institute of Bioscience, São Paulo State University (UNESP), 18618-000BotucatuSP, Brazil, Parasitology Department, Institute of Bioscience, São Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil.
authors.forename: Semíramis
authors.initials: S
authors.lastname: Guimarães
authors.affiliation: College of Veterinary Medicine and Animal Science (FMVZ), São Paulo State University (UNESP), 18618-000BotucatuSP, Brazil, College of Veterinary Medicine and Animal Science (FMVZ), São Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil.
authors.forename: Ana Paula Batista
authors.initials: AP
authors.lastname: Masseno
authors.affiliation: College of Veterinary Medicine and Animal Science (FMVZ), São Paulo State University (UNESP), 18618-000BotucatuSP, Brazil, College of Veterinary Medicine and Animal Science (FMVZ), São Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil.
authors.forename: Satie
authors.initials: S
authors.lastname: Katagiri
authors.affiliation: College of Veterinary Medicine and Animal Science (FMVZ), São Paulo State University (UNESP), 18618-000BotucatuSP, Brazil, College of Veterinary Medicine and Animal Science (FMVZ), São Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil.
authors.forename: Julio Lopes
authors.initials: JL
authors.lastname: Sequeira
mesh_terms: D000818:Animals; D001644:Bifidobacterium; D005243:Feces / Q000469:parasitology; D007411:Intestinal Diseases, Parasitic / Q000469:parasitology / Q000517:prevention & control*; D007413:Intestinal Mucosa / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010270:Parasite Egg Count; D019936:Probiotics / Q000008:administration & dosage*; D013321:Strongyloides / Q000145:classification / Q000254:growth & development*; D013322:Strongyloidiasis / Q000517:prevention & control*