title: Diet transiently improves migraine in two twin sisters: possible role of ketogenesis?
abstract: The ketogenic diet is a high-fat, low-carbohydrate diet long used to treat refractory epilepsy; ketogenesis (ketone body formation) is a physiological phenomenon also observed in patients following lowcarbohydrate, low-calorie diets prescribed for rapid weight loss. We report the case of a pair of twin sisters, whose high-frequency migraine improved during a ketogenic diet they followed in order to lose weight. The observed time-lock between ketogenesis and migraine improvement provides some insight into how ketones act to improve migraine.
authors.forename: Cherubino
authors.initials: C
authors.lastname: Di Lorenzo
authors.forename: Antonio
authors.initials: A
authors.lastname: Currà
authors.forename: Giulio
authors.initials: G
authors.lastname: Sirianni
authors.forename: Gianluca
authors.initials: G
authors.lastname: Coppola
authors.forename: Martina
authors.initials: M
authors.lastname: Bracaglia
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cardillo
authors.forename: Lorenzo
authors.initials: L
authors.lastname: De Nardis
authors.forename: Francesco
authors.initials: F
authors.lastname: Pierelli
mesh_terms: D055423:Diet, Ketogenic; D004200:Diseases in Twins / Q000178:diet therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000178:diet therapy*; D035781:Siblings