title: NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes.
abstract: NCG 4.0 is the latest update of the Network of Cancer Genes, a web-based repository of systems-level properties of cancer genes. In its current version, the database collects information on 537 known (i.e. experimentally supported) and 1463 candidate (i.e. inferred using statistical methods) cancer genes. Candidate cancer genes derive from the manual revision of 67 original publications describing the mutational screening of 3460 human exomes and genomes in 23 different cancer types. For all 2000 cancer genes, duplicability, evolutionary origin, expression, functional annotation, interaction network with other human proteins and with microRNAs are reported. In addition to providing a substantial update of cancer-related information, NCG 4.0 also introduces two new features. The first is the annotation of possible false-positive cancer drivers, defined as candidate cancer genes inferred from large-scale screenings whose association with cancer is likely to be spurious. The second is the description of the systems-level properties of 64 human microRNAs that are causally involved in cancer progression (oncomiRs). Owing to the manual revision of all information, NCG 4.0 constitutes a complete and reliable resource on human coding and non-coding genes whose deregulation drives cancer onset and/or progression. NCG 4.0 can also be downloaded as a free application for Android smart phones. Database URL: http://bio.ieo.eu/ncg/.
authors.affiliation: Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy and Division of Cancer Studies, King's College London, London SE1 1UL, UK.
authors.forename: Omer
authors.initials: O
authors.lastname: An
authors.forename: Vera
authors.initials: V
authors.lastname: Pendino
authors.forename: Matteo
authors.initials: M
authors.lastname: D'Antonio
authors.forename: Emanuele
authors.initials: E
authors.lastname: Ratti
authors.forename: Marco
authors.initials: M
authors.lastname: Gentilini
authors.forename: Francesca D
authors.initials: FD
authors.lastname: Ciccarelli
mesh_terms: D030541:Databases, Genetic; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D056726:Genetic Association Studies; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D020407:Internet; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D057386:Search Engine; D012984:Software
chemical_list: D035683:MicroRNAs