title: Genetic susceptibility of impulse control and related behavior in Parkinson's disease.
abstract: The human impulsivity-related trait has a complex background that is influenced by genetic and non-genetic factors. Impulsivity-related genetic factors have been evaluated in the field of psychiatry previously. Many previous reports have suggested that genetic variants associated with the hyperstimulation of the dopaminergic and serotonergic systems may have main roles in impulsivity. Although impulse control and related behaviors (ICRBs) in Parkinson's disease (PD) are now recognized as important nonmotor symptoms, ICRBs has seldom been evaluated for its genetic susceptibility in PD. This review will address genetic studies on ICRBs in the general population and PD. Although this trait has genetic susceptibility in part, it should not be crooked.
authors.affiliation: Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Korea.
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Kim
authors.affiliation: Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Korea.
authors.forename: Beom S
authors.initials: BS
authors.lastname: Jeon
mesh_terms: D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000150:complications* / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000150:complications* / Q000378:metabolism; D011954:Receptors, Dopamine / Q000235:genetics; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
chemical_list: D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012701:Serotonin; D018698:Glutamic Acid
keywords: Genetics; Parkinson's disease; impulse control disorders; polymorphism