title: Application of stem cell/growth factor system, as a multimodal therapy approach in regenerative medicine to improve cell therapy yields.
abstract: Stem cells hold a great promise for regenerative medicine, especially for replacing cells in infarcted organ that hardly have any intrinsic renewal capacity, including heart and brain. Signaling pathways that regulate pluripotency or lineage-specific gene and protein expression have been the major focus of stem cell research. Between them, there are some well known signaling pathways such as GF/GFR systems, SDF-1α/CXC4 ligand receptor interaction and PI3K/Akt signaling, and cytokines may regulate cell fate decisions, and can be utilized to positively influence cell therapy outcomes or accentuate synergistic compliance. For example, contributing factors in the progression of heart failure are both the loss of cardiomyocytes after myocardial infarction, and the absence of an adequate endogenous repair signaling. Combining cell engraftment with therapeutic signaling factor delivery is more exciting in terms of host progenitor/donor stem cell survival and proliferation. Thus stem cell-based therapy, besides triggering signaling pathways through GF/GFR systems can become a realistic option in regenerative processes for replacing lost cells and reconstituting the damaged organ, as before.
authors.affiliation: School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Clinical Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: mina_poorrajab@yahoo.com.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Pourrajab
authors.affiliation: School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Babaei Zarch
authors.affiliation: School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Baghi Yazdi
authors.affiliation: School of Nursing, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Rahimi Zarchi
authors.affiliation: School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Vakili Zarch
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects / Q000502:physiology; D018925:Chemokines / Q000378:metabolism; D003131:Combined Modality Therapy / Q000379:methods / Q000639:trends; D006333:Heart Failure / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage* / Q000378:metabolism; D044968:Regenerative Medicine / Q000379:methods / Q000639:trends*; D033581:Stem Cell Transplantation / Q000379:methods / Q000639:trends*; D013234:Stem Cells / Q000378:metabolism
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins
keywords: Growth factors; Regenerative medicine; Stem cell