title: Inhibitory effect of high temperature- and high pressure-treated red ginseng on exercise-induced oxidative stress in ICR mouse.
abstract: As previously reported, high temperature- and high pressure-treated red ginseng (HRG) contain higher contents of phenolic compounds and protect C2C12 muscle cells and 3T3-L1 adipocytes against oxidative stress. This study investigated the effect of HRG on oxidative stress using a mouse model. Our results show that the levels of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase, hepatic malondialdehyde in the HRG group were significantly lower than those of the exercise groups supplemented with commercial red ginseng (CRG) or not supplemented. The muscular glycogen level, glucose-6-phosphate dehydrogenase and lactate dehydrogenase activities of the HGR group were higher than that of the CGR group. Furthermore, the HRG treatment group displayed upregulated mRNA expression of Cu/Zn-SOD and muscle regulatory factor 4. These results indicate that HRG may protect oxidative stress induced by exercise as well as improve exercise performance capacity.
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. dbtjrdud@naver.com.
authors.forename: Seok-Yeong
authors.initials: SY
authors.lastname: Yu
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. yoonboll@naver.com.
authors.forename: Bo-Ra
authors.initials: BR
authors.lastname: Yoon
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. hslyj02@gmail.com.
authors.forename: Young-Jun
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. jongseoklee78@gmail.com.
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Korea Food Research Institute, Gyeonggi 463-746, Korea. honghd@kfri.re.kr.
authors.forename: Hee-Do
authors.initials: HD
authors.lastname: Hong
authors.affiliation: Korea Food Research Institute, Gyeonggi 463-746, Korea. yclee@kfri.re.kr.
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Lee
authors.affiliation: Korea Food Research Institute, Gyeonggi 463-746, Korea. yckim@kfri.re.kr.
authors.forename: Young-Chan
authors.initials: YC
authors.lastname: Kim
authors.affiliation: Korea Food Research Institute, Gyeonggi 463-746, Korea. cwcho@kfri.re.kr.
authors.forename: Chang-Won
authors.initials: CW
authors.lastname: Cho
authors.affiliation: Korea Food Research Institute, Gyeonggi 463-746, Korea. tack@kfri.re.kr.
authors.forename: Kyung-Tack
authors.initials: KT
authors.lastname: Kim
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. loh99@kangwon.ac.kr.
authors.forename: Ok-Hwan
authors.initials: OH
authors.lastname: Lee
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D019587:Dietary Supplements; D006003:Glycogen / Q000378:metabolism; D006358:Hot Temperature; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D018006:Myogenic Regulatory Factors / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D005894:Panax / Q000737:chemistry*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011312:Pressure; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D015430:Weight Gain
chemical_list: D018006:Myogenic Regulatory Factors; D010936:Plant Extracts; D012333:RNA, Messenger; C063403:myogenic factor 6; D008315:Malondialdehyde; D006003:Glycogen; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase