title: [Study on the hepatoxicity of polygoni multiflori radix and polygoni multiflori rodix praeparata in rats].
abstract: OBJECTIVE
  To compare the hepatoxicity of Polygoni Multiflori Radix and Polygoni Multiflori Rodix Praeparata in rats.
  
  
  METHODS
  Water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Rodix Praeparata were prepared by concentional decocting method (named as RPWE and PPWE respectively). Both in 30 days and 60 days experiments, SD rats were randomly divided into 5 groups: normal control group, RPWE high dosage group (40 mg/kg x d) and PPWE low dosage group (20 mg/kg x d), PPWE high dosage group (40 mg/kg x d) and PPEW low dosage group (20 mg/kg x d). After daily administration,the general conditions of rats were observed. At the end of the experiments, the levels of ALT and AST in plasma were detected. The liver coefficient was calculated and HE staining was used to observe the changes of liver tissue sections.
  
  
  RESULTS
  Both in 30 days and 60 days experiments, the treatment groups rats had hypokinesia and dry fur when compared with control groups, and in a dose-dependent manner. The liver coefficients, levels of ALT and AST of plasma weren't changed significantly when conpared with control groups. The liver had varying degrees of steatosis and inflammation cell infiltration in the treatment groups rats in 60 days experiment.
  
  
  CONCLUSIONS
  Oral administration of Polygoni Multiflori Radix and Polygoni Multiflori Rodix Praeparata for 60 days have hepatoxic in rats.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Rui-Chen
authors.initials: RC
authors.lastname: Zhang
authors.forename: Zhen-Xiao
authors.initials: ZX
authors.lastname: Sun
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001835:Body Weight; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D009929:Organ Size; D010936:Plant Extracts / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry; D028502:Polygonum / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D015415:Biomarkers; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts