title: Hematopoietic stem cells, infection, and the niche.
abstract: The immune response to infection is a rapid and multifaceted process. Infection affects homeostasis within the hematopoietic stem cell (HSC) niche, as lost immune cells must be replaced by HSCs. During the immune response, interferon is produced. Surprisingly, HSCs respond directly to interferon, entering the cell cycle from even the most dormant state. The complex response of both the HSCs and the niche to infection is a unique platform on which to consider HSC-niche interactions. Here, we comment on the contribution of the immune system to the niche and on the direct and indirect effect that infection has on HSCs in the niche.
authors.affiliation: Hematopoietic stem cells and stress group, Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany.
authors.forename: Aine M
authors.initials: AM
authors.lastname: Prendergast
authors.forename: Marieke A G
authors.initials: MA
authors.lastname: Essers
mesh_terms: D000818:Animals; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007239:Infections / Q000276:immunology*; D051379:Mice; D055153:Stem Cell Niche / Q000276:immunology*
keywords: hematopoietic stem cells; immunity; infection; interferon; niche