title: Case-control analysis of survival outcomes in sinonasal acinic cell carcinoma.
abstract: BACKGROUND
  Acinic cell carcinoma (AciCC) is an uncommon malignant-epithelial salivary gland cancer. In very rare cases, this tumor may arise from sinonasal subsites, with only 19 cases described in the English-language literature.
  
  
  METHODS
  We performed a retrospective analysis of 18 cases of AciCC, obtained from searching the Surveillance, Epidemiology, and End Results (SEER) database between 1973 and 2009.
  
  
  RESULTS
  Patient demographics, including age, gender, and race, were similar to AciCC cases found in more common locations. However, all patients had low-grade tumors without regional or distant metastases. Comparing these patients to a stage, grade, and treatment-matched cohort of parotid AciCC, we found a lower 10-year overall survival (52.3%) with no significant difference in disease-specific survival (88.9%). Our meta-analysis of survival from cases in the literature estimated 10-year recurrence-free survival at 92.9%.
  
  
  CONCLUSIONS
  To our knowledge, this is the largest cohort of patients with AciCC reported in the English-language literature. Our results suggest that patients with sinonasal AciCC have excellent disease-specific survival, comparable to matched patients with AciCC in more common salivary gland subsites.
authors.affiliation: Department of Otolaryngology, University of California Davis, Sacramento, CA.
authors.forename: Vincent L
authors.initials: VL
authors.lastname: Biron
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Lentsch
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Gerry
authors.forename: Arnaud F
authors.initials: AF
authors.lastname: Bewley
mesh_terms: D018267:Carcinoma, Acinar Cell / Q000401:mortality*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000401:mortality*; D010307:Parotid Neoplasms / Q000401:mortality; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome