title: [Research advances on abnormal marrow fibre in leukemia].
abstract: The genesis and development of leukemia not only associate to intrinsic factors, but also relate with the fibrous hyperplasia in the bone marrow. This review mainly focuses on the interaction between fiber-producing cells and leukemia cells, the relationship between fibrous hyperplasia and prognosis of leukemia, the regulation of TGF-beta, PDGF and other cytokines, the underlying mechanism of fibrous hyperplasia so as to explore the potential therapeutic targets for improving the prognosis of leukemia.
authors.affiliation: Physician, Professor, Tutor of Doctorial Postgraduate.
authors.forename: Yuan-Mei
authors.initials: YM
authors.lastname: Zhai
authors.affiliation: Physician, Professor, Tutor of Doctorial Postgraduate. E-mail:shiijun7@hotmail.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Shi
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D016207:Cytokines; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta