title: AKT isoform-specific signals regulate RNA processing in lung cancer.
abstract: IWS1 phosphorylation by AKT1 and AKT3 shifts splicing towards a tumorigenic FGFR2 isoform.
mesh_terms: D017398:Alternative Splicing; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D010766:Phosphorylation; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D020033:Protein Isoforms; D051497:Receptor, Fibroblast Growth Factor, Type 2; D051057:Proto-Oncogene Proteins c-akt