title: [Methylenetetrahydrofolate reductase polymorphism C677T in patients with consolidated fractures and pseudarthrosis of long bones: relationship with homocystein and inflammatory mediators].
abstract: In article described research the results of the prevalence of the genetic polymorphism of the gene Methylentetrahydrofolatereductase C677T (MTHFR) in 130 patients with pseudarthrosis of long bones and in those with consolidated fractures. The incidence of allele-T among patients with pseudarthrosis was 1.4 times higher than among those with consolidated fractures. Pathological genotype MTHFR 677-TT was associated with the development avital types of pseudarthrosis and increase the proportion of people with hyperhomocysteinemia, high content of inflammatory mediators and development refracture.
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Bezsmertnyĭ
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000276:immunology; D005260:Female; D017102:Fracture Healing / Q000235:genetics / Q000502:physiology; D005787:Gene Frequency; D006579:Heterozygote; D006620:Hip Fractures / Q000201:enzymology / Q000453:epidemiology; D006710:Homocysteine / Q000097:blood; D006720:Homozygote; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications / Q000201:enzymology* / Q000453:epidemiology / Q000276:immunology; D018836:Inflammation Mediators / Q000097:blood* / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic; D011542:Pseudarthrosis / Q000150:complications / Q000201:enzymology* / Q000453:epidemiology / Q000276:immunology; D013978:Tibial Fractures / Q000150:complications / Q000201:enzymology* / Q000453:epidemiology / Q000276:immunology
chemical_list: C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D006710:Homocysteine; D002097:C-Reactive Protein; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)