title: Palladium-catalyzed C-2 selective olefination of thiazoles.
abstract: A highly efficient protocol for C2 selective alkenylation of electron-deficient thiazoles is developed. High C2 position selectivity for alkenylation products is achieved at a neutral environment, and a possible pathway of oxidative alkenylation is discussed. This methodology provides a simple way to construct a 2-alkenyl-thiazole moiety.
authors.affiliation: Department of Chemistry, Tongji University , Siping Road 1239, Shanghai 200092, P. R. China and Key Laboratory of Yangtze River Water Environment, Ministry of Education, Siping Road 1239, Shanghai 200092, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Kuang
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000475:Alkenes; D013844:Thiazoles; D010165:Palladium