title: Pharmacogenomics of episodic migraine: time has come for a step forward.
abstract: Migraine is characterized by heterogeneous behavior in response to drugs. Many resources have been invested in attempting to unravel the genetic basis of migraine, while the role of genetics in responses to currently available drugs has received less attention. We performed a systematic literature search identifying original articles pertaining to pharmacogenomics of episodic migraine. Few primary studies on the pharmacogenomics of symptomatic and preventive medication in episodic migraine were found. The number of patients studied in the individual articles ranged from 40 up to 130. There was a strong heterogeneity among these studies. We believe that pharmacogenomics studies, if properly designed, could contribute towards optimizing the treatment and reducing the burden of migraine, in turn helping patients and optimizing resources. Our knowledge on the pharmacogenomics of migraine is growing too slowly, and concerted measures should be undertaken to speed up the process.
authors.affiliation: Headache Science Centre, C. Mondino National Institute of Neurology Foundation, IRCCS, Pavia, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Viana
authors.forename: Salvatore
authors.initials: S
authors.lastname: Terrazzino
authors.forename: Armando A
authors.initials: AA
authors.lastname: Genazzani
authors.forename: Gaetano S
authors.initials: GS
authors.lastname: Grieco
authors.forename: Sarah
authors.initials: S
authors.lastname: Cargnin
authors.forename: Filippo M
authors.initials: FM
authors.lastname: Santorelli
authors.forename: Francesco
authors.initials: F
authors.lastname: Pierelli
authors.forename: Cristina
authors.initials: C
authors.lastname: Tassorelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nappi
authors.forename: Cherubino
authors.initials: C
authors.lastname: Di Lorenzo
mesh_terms: D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000235:genetics*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010597:Pharmacogenetics / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D004364:Pharmaceutical Preparations