title: Effects of partial tonsillectomy on the immune functions of children with obstructive sleep apnea-hypopnea syndrome at early stage.
abstract: The purpose of this study was to investigate the changes in the humoral and cellular immunity of children with obstructive sleep apnea-hypopnea syndrome and hypertrophy of tonsils before and after plasma-mediated temperature-controlled radiofrequency ablation treatment. Fifty-seven children suffering from obstructive sleep apnea-hypopnea syndrome and with hypertrophy of tonsils were enrolled in this study. Thirty-seven children were grouped in the partial tonsillectomy group and 20, in the tonsillectomy group. The levels of CD3(+), CD4(+), CD8(+), and CD4(+)/CD8(+) were measured for cellular immunity, and the levels of IgG, IgA, and IgM were measured for humoral immunity. Blood samples were collected before and 1 and 3 months after the operation. The IgG, IgA, and IgM levels in the tonsillectomy group were significantly decreased 1 month after the operation, and recovered to the normal levels within 3 months of the operation (P < 0.05). However, the levels of IgG, IgA, and IgM in the partial tonsillectomy group decreased slightly, without a significant difference (P > 0.05). The cellular immunity of the 2 groups was not statistically different pre- and post-operation (P > 0.05). The results from the present study indicate that partial tonsillectomy by plasma-mediated temperature-controlled radiofrequency ablation did not impact on the humoral and cellular immunity of children.
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital of PLA General Hospital, Beijing, China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Dai
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China.
authors.forename: D Y
authors.initials: DY
authors.lastname: Huang
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital of PLA General Hospital, Beijing, China chengyongzhoucn@163.com.
authors.forename: C Y
authors.initials: CY
authors.lastname: Zhou
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D008297:Male; D014066:Palatine Tonsil / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D011184:Postoperative Period; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D014068:Tonsillectomy