title: Evaluation of the biocompatibility of experimentally manufactured portland cement: An animal study.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the biocompatibility of MTA and the experimentally manufactured portland cement (EMPC).
  
  
  METHODS
  Twenty one Sprague Dawley (SD) rats were allocated to testing of three groups. Group I and Group II included ProRoot MTA and the EMPC. The materials were mixed with distilled water and placed in polyethylene tubes. The tubes were implanted subcutaneously in the dorsal region of the animals. Group III served as control; the implanted polyethylene tubes remained empty. At 7, 14, and 28 days after the implantation, the animals were sacrificed and the implants were removed with the surrounding tissues. The specimens were prepared for histological examination to evaluate the inflammatory response.
  
  
  RESULTS
  No significant difference was found between tissue reactions against the tested materials (p>0.05). Also, control group showed similar results (p>0.05).
  
  
  CONCLUSIONS
  Results suggest that the EMPC has the potential to be used in clinical conditions in which ProRoot MTA is indicated. MTA and the EMPC show comparable biocompatibility when evaluated in vivo. Although the results are supportive for the EMPC, more studies are required before the safe clinical use of the EMPC. Key words:Mineral trioxide aggregate, portland cement, subcutanous implantation.
authors.affiliation: Department of Endodontics, Faculty of Dentistry, Bülent Ecevit University, Zonguldak, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Koçak
authors.affiliation: Department of Restoratif Dentistry, Faculty of Dentistry, Gazi University, Ankara, Turkey.
authors.forename: Hülya
authors.initials: H
authors.lastname: Erten
authors.affiliation: Department of Oral Pathology, Faculty of Dentistry, Gazi University, Ankara, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Baris
authors.affiliation: Department of Endodontics, Faculty of Dentistry, Gazi University, Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Türk
authors.affiliation: Turkish Cement Manufacturers' Association, Ankara, Turkey.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Alaçam