title: Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate the complete metabolic and phenotypic profiles of a large cohort of untreated, consecutively recruited Korean women with polycystic ovary syndrome (PCOS), for whom a registry for Korean women with PCOS was constructed.
  
  
  METHODS
  Observational study.
  
  
  METHODS
  Three infertility clinics and 10 university hospitals.
  
  
  METHODS
  Eight hundred sixty-five women with PCOS were recruited using the Rotterdam criteria.
  
  
  METHODS
  Standardized evaluation protocol and web-based case report form.
  
  
  METHODS
  Metabolic and phenotypic profiles.
  
  
  RESULTS
  The subjects with PCOS mainly consisted of young and nonobese women. The most problematic subjective symptom was menstrual disturbance or infertility, and, on average, the patients seemed to menstruate every 2 months. PCO morphology was observed in 96.5% of the patients. Although few women visited hospitals owing to HA symptoms alone, hirsutism was observed in one-third of the patients (33.9%) and half (47.4%) of the patients had biochemical HA. About one-fifth (20.1%) of the patients had generalized obesity, and one-third (33.2%) had central obesity. Prevalence of dyslipidemia, diabetes, hypertension, and metabolic syndrome were 35.7%, 3.5%, 4.0%, and 13.7%, respectively. Prevalence of prediabetes was 20.8%, and a substantial proportion of additional subjects with normal fasting plasma glucose or oral glucose tolerance tests were identified as having prediabetes by hemoglobin A1C testing.
  
  
  CONCLUSIONS
  Our well-defined cohort provided comprehensive estimates of the features of metabolic and phenotypic profiles related to PCOS in Korean women. Further longitudinal follow-up studies are needed to investigate the changes in phenotypic and metabolic markers in this PCOS cohort.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea; Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea.
authors.forename: Jin Ju
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea; Department of Obstetrics and Gynecology, Seoul Metropolitan Government (SMG)-Seoul National University (SNU) Boramae Medical Center, Seoul, South Korea.
authors.forename: Kyu Ri
authors.initials: KR
authors.lastname: Hwang
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: ymchoi@snu.ac.kr.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
authors.affiliation: Department of Obstetrics and Gynecology, Maria Fertility Hospital, Seoul, South Korea.
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Chae
authors.affiliation: Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea.
authors.forename: Chan Woo
authors.initials: CW
authors.lastname: Park
authors.affiliation: Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea.
authors.forename: Hye Ok
authors.initials: HO
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Seoul Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
authors.forename: Doo Seok
authors.initials: DS
authors.lastname: Choi
authors.affiliation: Department of Obstetrics and Gynecology, Miraewa-heemang Hospital, Seoul, South Korea.
authors.forename: Hyuck Chan
authors.initials: HC
authors.lastname: Kwon
authors.affiliation: Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: Byung Moon
authors.initials: BM
authors.lastname: Kang
authors.affiliation: Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea.
authors.forename: Byung Seok
authors.initials: BS
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea.
authors.forename: Si Hyun
authors.initials: SH
authors.lastname: Cho
authors.affiliation: Department of Obstetrics and Gynecology, Mizmedi Women's Hospital, Seoul, South Korea.
authors.forename: Tai June
authors.initials: TJ
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Tak
authors.initials: T
authors.lastname: Kim
authors.affiliation: Division of Cardiovascular and Rare Diseases, Korea National Institute of Health, Chungbuk, South Korea.
authors.forename: Min Ju
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Division of Cardiovascular and Rare Diseases, Korea National Institute of Health, Chungbuk, South Korea.
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Park
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005951:Glucose Tolerance Test / Q000639:trends; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000208:ethnology / Q000235:genetics / Q000378:metabolism; D055442:Metabolome / Q000235:genetics* / Q000502:physiology; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism*; D056910:Republic of Korea / Q000208:ethnology; D055815:Young Adult
keywords: Metabolic syndrome; Rotterdam criteria; phenotype; polycystic ovary syndrome; type 2 diabetes