title: Reference intervals and factors contributing to serum glycated albumin levels in West China.
abstract: BACKGROUND
  In diabetic patients, non-enzymatically glycated albumin (GA), Amadori adducts, has been suggested as an ideal biomarker of short-term glycemic control.
  
  
  OBJECTIVE
  To describe the reference intervals of serum GA and identify factors associated with serum GA, including age, gender, hemoglobin A1C (HbA1c) levels, fasting blood glucose (FPG) levels, total glycerin (TG) levels, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), systolic pressure (SBP) and diastolic pressure (DBP).
  
  
  METHODS
  This study enrolled 1,296 healthy participants aged between 18 to 84 years of age attending physical tests in West China. Serum GA, blood glucose, blood lipid, and HbA1c levels were tested with commercially available reagents on automated clinical chemistry analyzers.
  
  
  RESULTS
  In the West China population, the levels of serum GA concentrations were 11.6% (95% CI, 11.4 - 11.7) for overall population and 11.3% (95% CI, 11.1 - 11.4) and 11.9% (95% CI, 11.8 - 12.0) for males and females, respectively. In contrast, in a multiple model, gender (beta = 0.127), age (beta = 0.125), and HbAlc (beta = 0.177) were positively correlated with GA whilst body mass index (BMI) (beta = -0.197) and TG (beta = -0.153) were negatively correlated with GA.
  
  
  CONCLUSIONS
  The reference intervals of GA were partitioned into five categories by age and gender; 8.7 - 13.7% for subjects aged 18 to 29 including both male and female, 8.1 - 13.7% for 30 to 49 years old males, 9.4 - 14.2% for 30 - 49 years old females, 9.1 - 14.9% for male and female subjects aged 50 - 59 and 9.6 - 15.7% for the male and female subjects over the age of 60 years.
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: He
authors.initials: H
authors.lastname: He
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Ruixue
authors.initials: R
authors.lastname: Lv
authors.affiliation: Department of General Practice Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Shuangqing
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of General Practice Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Libo
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Zhenmei
authors.initials: Z
authors.lastname: An
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Hengjian
authors.initials: H
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis; D002681:China; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D017127:Glycation End Products, Advanced; D006801:Humans; D008297:Male; D008875:Middle Aged; D012015:Reference Standards; D012709:Serum Albumin / Q000032:analysis*; D055815:Young Adult; D000093423:Glycated Serum Albumin
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin; C517652:hemoglobin A1c protein, human