title: Mechanisms mediating renal sympathetic nerve activation in obesity-related hypertension.
abstract: Excessive renal sympathetic nerve activation may be one of the mechanisms underlying obesity-related hypertension. Impaired baroreflex sensitivity, adipokine disorders-such as leptin, adiponectin, and resistin-activation of the renin-angiotensin system, hyperinsulinemia, insulin resistance, and renal sodium retention present in obesity increase renal sympathetic nerve activity, thus contributing to the development of hypertension. Renal sympathetic denervation reduces both renal sympathetic activity and blood pressure in patients with obesity-related hypertension.
authors.affiliation: Department of Cardiology, The Third Xiangya Hospital, Central South University, 410013, Changsha, China.
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Leo
authors.forename: C
authors.initials: C
authors.lastname: Weng
authors.forename: X
authors.initials: X
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: X
authors.initials: X
authors.lastname: Tang
mesh_terms: D000818:Animals; D017704:Baroreflex; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000294:innervation* / Q000503:physiopathology*; D008955:Models, Cardiovascular; D009765:Obesity / Q000150:complications* / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*