title: B cells tell scleroderma fibroblasts to produce collagen.
abstract: In fibrosis fibroblasts are activated and overproduce collagen in a process with unknown drivers and equally unknown brakes that recently implicated a novel and surprising player, the B cell. B cells may be crucially involved in fibrosis in several ways: B cells may produce autoantibodies that can directly stimulate fibroblasts; B cells can produce profibrotic cytokines such as IL-6 or transforming growth factor beta; and, finally, B cells could directly stimulate fibroblasts by a contact-dependent mechanism. Recent experimental evidence suggests that B cells can enhance collagen production by fibroblasts, by a contact-dependent mechanism, and therefore are profibrotic ex vivo. These data strengthen the rationale of pursuing B-cell targeting therapies in systemic sclerosis.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Daoussis
authors.forename: Stamatis-Nick C
authors.initials: SN
authors.lastname: Liossis
mesh_terms: D053264:B-Cell Activating Factor / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D003094:Collagen / Q000276:immunology*; D005347:Fibroblasts / Q000276:immunology*; D006801:Humans
chemical_list: D053264:B-Cell Activating Factor; D003094:Collagen