title: [Clinical observation on acupuncture for diarrhea-predominant irritable bowel syndrome patients in syndrome of liver-stagnation and spleen-deficiency and its impact on Th1/Th2].
abstract: OBJECTIVE
  To observe clinical therapeutic effects of acupuncture for pattern of liver-stagnation and spleen-deficiency in diarrhea-predominant irritable bowel syndrome (D-IBS) and its impact on cell factors.
  
  
  METHODS
  Forty cases were selected and divided into an acupuncture group (21 cases) in which acupuncture was applied and a medicine group (19 cases) in which oral administration of dicetel and bifidobacterium lactobacillus triple viable capsules were applied. The symptom scores, level of Th1-type cytokine (IFN-gamma, IL-2) and Th2-type cytokine (IL-4, IL-10) and ratio of IFN-gamma to IL-4 were compared in two groups before and after treatment to analyze acupuncture effect.
  
  
  RESULTS
  The clinical symptoms were improved after one-week treatment in the acupuncture group (P<0.05), which had faster onset than the medicine group (P<0.05). The total effective rate was 90.48% (19/21) in the acupuncture group, which was superior to 78.95% (15/19) in the medicine group (P<0.05). Compared with medicine treatment, imbalanced condition of Th1/Th2 was turning towards the direction of Th2 after acupuncture, indicating a tendency to recover the balance.
  
  
  CONCLUSIONS
  The clinical efficacy of acupuncture for D-IBS has close relationship with effectively improving balance of Th1/Th2 in patients with liver-stagnation and spleen-deficiency.
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Wu
authors.forename: Ye-Lin
authors.initials: YL
authors.lastname: Wang
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Sun
authors.forename: Yan-Ye
authors.initials: YY
authors.lastname: Shu
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Pei
authors.forename: Jun-Ling
authors.initials: JL
authors.lastname: Zhou
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.forename: Ji-Wei
authors.initials: JW
authors.lastname: Zhang
authors.forename: Dao-Wei
authors.initials: DW
authors.lastname: Zhan
mesh_terms: D015670:Acupuncture Therapy; D000328:Adult; D000368:Aged; D016207:Cytokines / Q000276:immunology; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D008099:Liver / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000503:physiopathology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D055815:Young Adult
chemical_list: D016207:Cytokines