title: The relationship between red-cell distribution width and abnormal left ventricle geometric patterns in patients with untreated essential hypertension.
abstract: Abnormal left ventricle (LV) geometric patterns are associated with an increased risk of vascular complications of hypertension (HT). The association between red-cell distribution width (RDW) and HT has been recently investigated; however, the relationship between abnormal LV geometric patterns and RDW has not been studied before. The aim of this study was to investigate the relationship between RDW and abnormal LV geometric patterns in patients with untreated essential HT. Measurements were obtained from 139 patients with untreated essential HT (mean age=51.3±16.3 years). Four different geometric patterns (NG, normal geometry; CR, concentric remodeling; EH, eccentric hypertrophy; CH, concentric hypertrophy) were determined according to the LV mass index (LVMI) and relative wall thickness (RWT). RDW, lipid parameters and other biochemical markers were measured in all patients. While the highest RDW values were detected in the CH group (P<0.05, for all), it was similar among the NG, CR and EH groups (P>0.05, for all). RDW was associated with age, LVMI and LV geometry in bivariate analysis (P<0.05, for all). In a receiver operating characteristic (ROC) curve analysis, a level of RDW>14.5 predicted CH with 81% sensitivity and 59% specificity. Age (beta=0.309, P=0.001), LV geometry type (beta=0.228, P=0.01) and RWT (beta=-0.278; P=0.25) were independent predictors of high RDW in multiple linear regression analysis. In conclusion, the highest RDW values were observed in the CH group in the untreated essential HT patients. RDW seems to be a useful tool for the prediction of end-organ damage in patients with untreated essential HT.
authors.affiliation: Department of Cardiology, İzmir Tepecik Research and Training Hospital, Izmir, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Kilicaslan
authors.affiliation: Department of Cardiology, İzmir Tepecik Research and Training Hospital, Izmir, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Dursun
authors.affiliation: Department of Cardiology, İzmir Tepecik Research and Training Hospital, Izmir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aydin
authors.affiliation: Department of Cardiology, İzmir Tepecik Research and Training Hospital, Izmir, Turkey.
authors.forename: Cenk
authors.initials: C
authors.lastname: Ekmekci
authors.affiliation: Department of Cardiology, İzmir Tepecik Research and Training Hospital, Izmir, Turkey.
authors.forename: Oner
authors.initials: O
authors.lastname: Ozdogan
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003430:Cross-Sectional Studies; D004452:Echocardiography; D004909:Erythrocyte Indices; D000075222:Essential Hypertension; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000000981:diagnostic imaging*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D012680:Sensitivity and Specificity; D020257:Ventricular Remodeling