title: Water-induced shape-memory poly(D,L-lactide)/microcrystalline cellulose composites.
abstract: Thermo-induced shape-memory polymers (SMPs) have been widely investigated, but their biomedical applications are limited because their switching temperature does not fall completely within the range of room temperature to body temperature. In this study, we prepared water-induced shape-memory composites composed of microcrystalline cellulose (MCC) and poly(d,l-lactide) (PDLLA). We observed that the composite with an MCC content of 35% (PDLLA-MCC-35) exhibited a good shape-memory effect upon exposure to water at 37°C. We also analyzed the mechanism of the water-triggered shape-memory effect by considering the microstructure, water contact angle, water uptake, thermal properties and static and dynamic mechanical properties of the composite. The results of in vitro degradation analysis demonstrate that the composites exhibited good biodegradation. In addition, Alamar blue assays based on osteoblasts indicate that the composites possess good cytocompatibility. Therefore, the water-induced shape-memory composite can potentially be developed into a new smart medical device.
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Chen
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China. Electronic address: shaobingzhou@swjtu.edu.cn.
authors.forename: Shaobing
authors.initials: S
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D063566:Biodegradable Plastics / Q000737:chemistry* / Q000494:pharmacology; D002236:Carbohydrate Conformation; D002460:Cell Line; D002482:Cellulose / Q000737:chemistry* / Q000494:pharmacology; D006358:Hot Temperature; D010006:Osteoblasts / Q000187:drug effects; D011091:Polyesters / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D063566:Biodegradable Plastics; D011091:Polyesters; D014867:Water; C033616:poly(lactide); D002482:Cellulose; C109691:microcrystalline cellulose
keywords: Biodegradable; Composites; Microcrystalline cellulose; Shape memory