title: Basaloid squamous cell carcinoma: a rare tumor at the esophagogastric junction and an unexpected durable complete response to FOLFOX-4.
abstract: BACKGROUND
  Basaloid squamous cell carcinoma (BSCC) is a high-grade variant of squamous cell carcinoma usually localized in the aerodigestive tract, with a poor prognosis. Surgical resection is generally recommended, even if no standard treatment has been established yet.
  
  
  METHODS
  Here, we report the case history of a patient diagnosed with BSCC at the esophagogastric junction who was successfully treated with chemotherapy alone, leading to a durable complete response.
  
  
  CONCLUSIONS
  The presented case illustrates the diagnostic challenges associated with BSCC of the esophagus and reports an unexpected chemosensitivity of this histotype to the combination of a platinum salt plus 5-fluorouracil, which could represent an optimal treatment strategy in unfit patients.
authors.affiliation: Federico II University of Naples, Italy.
authors.forename: Chiara A
authors.initials: CA
authors.lastname: Cella
authors.forename: Chiara
authors.initials: C
authors.lastname: Carlomagno
authors.forename: Florian
authors.initials: F
authors.lastname: Lordick
authors.forename: Roberto
authors.initials: R
authors.lastname: Moretto
authors.forename: Alfonso
authors.initials: A
authors.lastname: De Stefano
authors.forename: Lucia
authors.initials: L
authors.lastname: Raimondo
authors.forename: Maria
authors.initials: M
authors.lastname: D'Armiento
authors.forename: Luigi
authors.initials: L
authors.lastname: Camera
authors.forename: Elia
authors.initials: E
authors.lastname: Guadagno
authors.forename: Laura
authors.initials: L
authors.lastname: Attademo
authors.forename: Salvatore
authors.initials: S
authors.lastname: Feliciano
authors.forename: Elide
authors.initials: E
authors.lastname: Matano
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology*; D004943:Esophagogastric Junction / Q000473:pathology*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D035583:Rare Diseases / Q000188:drug therapy / Q000473:pathology; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil