title: An update of the impact of deep brain stimulation on non motor symptoms in Parkinson's disease.
abstract: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established therapy for patients with Parkinson's disease (PD), especially those with advanced motor complications. The effect of STN DBS on non motor symptoms (NMS) of PD is less well studied. In this article, we review the pertinent literature on the impact of STN DBS on NMS when they co-exist with disabling motor symptoms in PD patients. We also present evidence that the number and the severity of most NMS decrease after STN DBS which can have a major impact on patients' quality of life.
authors.affiliation: National Parkinson Foundation International Centre of Excellence, Department of Neurology, King's College Hospital and King's College, Denmark Hill, London, UK Department of Neurology, Technical University Dresden, Dresden, Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Klingelhoefer
authors.affiliation: National Parkinson Foundation International Centre of Excellence, Department of Neurology, King's College Hospital, Denmark Hill, London, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Samuel
authors.affiliation: National Parkinson Foundation International Centre of Excellence, Department of Neurology, King's College Hospital and King's College, Denmark Hill, London, UK.
authors.forename: K Ray
authors.initials: KR
authors.lastname: Chaudhuri
authors.affiliation: Department of Neurosurgery, King's College Hospital, Denmark Hill, London, UK.
authors.forename: Keyoumars
authors.initials: K
authors.lastname: Ashkan
mesh_terms: D001526:Behavioral Symptoms / Q000150:complications / Q000628:therapy; D003072:Cognition Disorders / Q000150:complications / Q000628:therapy; D046690:Deep Brain Stimulation; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000150:complications / Q000628:therapy; D006801:Humans; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy*; D011788:Quality of Life; D012893:Sleep Wake Disorders / Q000150:complications / Q000628:therapy; D020531:Subthalamic Nucleus / Q000601:surgery
keywords: DBS; Deep brain stimulation; GPi; PD; Parkinson's disease; STN; internal globus pallidus; non motor symptoms; subthalamic nucleus