title: Promising outcomes of screening for pancreatic cancer by genetic testing and endoscopic ultrasound.
abstract: OBJECTIVE
  This study aimed to determine if screening patients based on certain cancer syndromes or family history criteria can lead to early detection of pancreatic cancer.
  
  
  METHODS
  This was a cohort study from 2008 to 2011 at a large tertiary referral center. A total of 30 patients met high-risk criteria after genetic counseling and were referred to a gastroenterologist for possible endoscopic ultrasound (EUS).
  
  
  RESULTS
  Of the 30 patients, 16 underwent EUS. Subsequently, 3 patients had fine needle aspiration. Two patients had pancreatic adenocarcinoma, and 1 patient had an intraductal papillary mucinous neoplasm with low-grade dysplasia. The 2 patients with pancreatic adenocarcinoma both had breast cancer and BRCA2 mutations. The patient with the intraductal papillary mucinous neoplasm had Peutz-Jeghers syndrome. All 3 patients underwent surgery and have remained cancer free.
  
  
  CONCLUSIONS
  Genetic risk assessment with EUS +/- fine needle aspiration in high-risk patients may lead to earlier detection of pancreatic cancer and potentially improve overall morbidity and mortality. Greater emphasis should be placed on screening patients for hereditary cancer syndromes that increase the risk of pancreatic cancer.
authors.affiliation: From the *Department of Gastroenterology, †Genetic Counseling Program, Aurora St Luke's Medical Center, Milwaukee; and ‡University of Wisconsin School of Medicine and Public Health, Madison, WI.
authors.forename: Anchal
authors.initials: A
authors.lastname: Sud
authors.forename: Deborah
authors.initials: D
authors.lastname: Wham
authors.forename: Marc
authors.initials: M
authors.lastname: Catalano
authors.forename: Nalini M
authors.initials: NM
authors.lastname: Guda
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D000328:Adult; D000368:Aged; D024682:BRCA2 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics; D021441:Carcinoma, Pancreatic Ductal / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D015331:Cohort Studies; D055088:Early Detection of Cancer / Q000379:methods; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000379:methods; D019160:Endosonography / Q000379:methods*; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D017063:Outcome Assessment, Health Care / Q000379:methods*; D010179:Pancreas / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000235:genetics; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D062606:Tertiary Care Centers / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D024682:BRCA2 Protein