title: Could platelet distribution width be a predictive marker for unexplained recurrent miscarriage?
abstract: OBJECTIVE
  The aim of our study was to evaluate the platelet function in unexplained recurrent miscarriage and to investigate whether any hematologic changes detectable by simple complete blood count have a diagnostic value for the prediction of unexplained recurrent miscarriage.
  
  
  METHODS
  A prospective study based on the comparison of 74 patients with unexplained recurrent first-trimester pregnancy loss with 208 control subjects matched for age. The two groups were compared in terms of platelet indices.
  
  
  RESULTS
  There was a significant difference in platelet distribution width in patients with unexplained recurrent miscarriage compared to healthy control subjects. Platelet distribution width values in the patient group were statistically higher (P < 0.001) than the control group.
  
  
  CONCLUSIONS
  Our study provides an evidence that platelet distribution width gradually increases in women with recurrent miscarriage compared to control group. Patients with unexplained recurrent miscarriage have significantly increased platelet aggregation. This data may provide an empirical rationale for the use of anticoagulants in the management of this clinical condition.
authors.affiliation: Department of Obstetrics and Gynecology, Recep Tayyip Erdoğan University, School of Medicine, Rize, İslampaşa Mah, 53100, Turkey, ulkumete2004@yahoo.com.
authors.forename: Ulkü
authors.initials: U
authors.lastname: Mete Ural
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Bayoğlu Tekin
authors.forename: Gülşah
authors.initials: G
authors.lastname: Balik
authors.forename: Figen
authors.initials: F
authors.lastname: Kir Şahin
authors.forename: Sabri
authors.initials: S
authors.lastname: Colak
mesh_terms: D000026:Abortion, Habitual / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D010979:Platelet Function Tests; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000925:Anticoagulants; D015415:Biomarkers