title: Pustular psoriasis in childhood and adolescence: a 20-year single-center experience.
abstract: Pustular psoriasis (PP) is rare in children. The small number of reported cases makes deciding on treatment and follow-up challenging. The current study was an evaluation of treatment approaches and courses of PP in 18 children diagnosed and followed over a 20-year period. From 1992 to 2011 we treated 1,447 children with psoriasis, 18 of whom had PP. Follow-up was 2 to 19 years. At the time of initial manifestation of PP, our patients were 1.5 months to 16 years old. Seven patients had a previous history of psoriasis vulgaris. Three children entered long-term remission after one pustular attack, 10 developed psoriasis vulgaris, 2 are currently under treatment, and 3 were lost to follow-up. Treatment with acitretin, cyclosporine, or methotrexate was efficacious and well tolerated. PP is rare, but according to our experience, it has a good prognosis in children.
authors.affiliation: Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, Serbia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Popadic
authors.forename: Milos
authors.initials: M
authors.lastname: Nikolic
mesh_terms: D017255:Acitretin / Q000627:therapeutic use; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007641:Keratolytic Agents / Q000627:therapeutic use; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy* / Q000453:epidemiology*; D055771:Serbia / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D005938:Glucocorticoids; D007641:Keratolytic Agents; D016572:Cyclosporine; D017255:Acitretin; D011241:Prednisone