title: Myeloproliferative hypereosinophilic syndrome presenting as cardiac failure and response to imatinib.
abstract: Idiopathic hypereosinophilic syndrome was first defined by Chursid et al in 1975; however, following the advances in molecular biology, the World Health Organization has proposed a classification in 2008. Hypereosinophilic syndrome is a heterogeneous group of uncommon disorders characterized by marked peripheral eosinophilia and end-organ manifestation. The authors describe a case of sudden-onset cardiac failure in a young individual who had marked peripheral eosinophilia and detection of FIP1L1/PDGFRA fusion gene. A diagnosis of myeloproliferative neoplasm with eosinophilia and eosinophilic endocarditis was made. His clinical and laboratory parameters showed a dramatic response to imatinib and prednisone.
authors.affiliation: 1Department of Medicine, Cooper University Hospital, Camden, NJ; and 2Department of Medicine, Seth G S Medical College and KEM Hospital, Parel, India.
authors.forename: Nayan
authors.initials: N
authors.lastname: Desai
authors.forename: Sandeep
authors.initials: S
authors.lastname: Morkhandikar
authors.forename: Ravindranath
authors.initials: R
authors.lastname: Sahay
authors.forename: Farah
authors.initials: F
authors.lastname: Jijina
authors.forename: Pritesh
authors.initials: P
authors.lastname: Patil
mesh_terms: D000328:Adult; D001549:Benzamides / Q000627:therapeutic use*; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D000068877:Imatinib Mesylate; D008297:Male; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D010879:Piperazines / Q000627:therapeutic use*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate