title: Screening of the central nervous system in children with invasive pulmonary aspergillosis.
abstract: The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.
authors.affiliation: Department of Pediatrics, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Emmi
authors.initials: E
authors.lastname: Broenen
authors.affiliation: Department of Pediatrics, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Annelies
authors.initials: A
authors.lastname: Mavinkurve-Groothuis
authors.affiliation: Department of Radiology, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Karin
authors.initials: K
authors.lastname: Kamphuis-van Ulzen
authors.affiliation: Department of Clinical Pharmacy, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands ; Nijmegen Institute for Infection, Immunity and Inflammation, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Roger
authors.initials: R
authors.lastname: Brüggemann
authors.affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands ; Nijmegen Institute for Infection, Immunity and Inflammation, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Paul
authors.initials: P
authors.lastname: Verweij
authors.affiliation: Department of Pediatrics, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands ; Nijmegen Institute for Infection, Immunity and Inflammation, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Adilia
authors.initials: A
authors.lastname: Warris
keywords: Aspergillosis; Central nervous system; Pediatrics; Screening; Therapeutic drug monitoring; Voriconazole