title: Improving reproductive long-term prognosis for women with a first ectopic pregnancy. A national controlled follow-up study.
abstract: OBJECTIVE
  To describe developments in reproductive long-term prognosis in women with a first ectopic pregnancy as compared with two control cohorts.
  
  
  METHODS
  Controlled cohort study.
  
  
  METHODS
  Data were collected from four national Danish registries.
  
  
  METHODS
  All Danish women of reproductive age (15-49 years) through the period 1977-2009 and all reproductive outcomes in these women.
  
  
  METHODS
  Data were collected from four national Danish registries. Three cohorts of women with a first recorded ectopic pregnancy during the periods 1980-84, 1985-89, and 1990-94, were compared with age-matched controls with a first miscarriage and a first induced abortion and followed for 15 years for all further pregnancy outcomes.
  
  
  METHODS
  Pregnancy outcomes included deliveries, miscarriages, induced abortions and ectopic pregnancies.
  
  
  RESULTS
  The birth rate for women with a first ectopic pregnancy increased significantly through the three cohorts from 85 to 122 deliveries/100 women during the follow-up period. The risk of miscarriages also increased over time, whereas the risk of further ectopic pregnancies remained unchanged at 22-24 events/100 women. Compared to women with a first miscarriage, the rate ratio for deliveries increased from 0.59 (95% CI 0.56-0.63) to 0.71 (95% CI 0.68-0.75) over the time covering the three cohorts.
  
  
  CONCLUSIONS
  The long-term delivery rate among women with a first ectopic pregnancy has improved significantly over time.
authors.affiliation: Department of Gynecology, Rigshospitalet University Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Pia
authors.initials: P
authors.lastname: Egerup
authors.forename: Line Lund
authors.initials: LL
authors.lastname: Kårhus
authors.forename: Charlotte Wessel
authors.initials: CW
authors.lastname: Skovlund
authors.forename: Ojvind
authors.initials: O
authors.lastname: Lidegaard
mesh_terms: D000028:Abortion, Induced / Q000706:statistics & numerical data*; D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D001723:Birth Rate / Q000639:trends*; D016022:Case-Control Studies; D003718:Denmark; D005260:Female; D005500:Follow-Up Studies; D020073:Gravidity; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011271:Pregnancy, Ectopic / Q000453:epidemiology*; D013997:Time Factors; D055815:Young Adult
keywords: Ectopic pregnancy; delivery rate; development in reproductive prognosis; early pregnancy complications; fertility