title: MicroRNA expression signatures determine prognosis and survival in glioblastoma multiforme--a systematic overview.
abstract: Despite advances in our knowledge about glioblastoma multiforme (GBM) pathology, clinical challenges still lie ahead with respect to treatment in GBM due to high prevalence, poor prognosis, and frequent tumor relapse. The implication of microRNAs (miRNAs) in GBM is a rapidly expanding field of research with the aim to develop more targeted molecular therapies. This review aims to present a comprehensive overview of all the available literature, evaluating miRNA signatures as a function of prognosis and survival in GBM. The results are presented with a focus on studies derived from clinical data in databases and independent tissue cohorts where smaller samples sizes were investigated. Here, miRNA associated to longer survival (protective) and miRNA with shorter survival (risk-associated) have been identified and their signatures based on different prognostic attributes are described. Finally, miRNAs associated with disease progression or survival in several studies are identified and functionally described. These miRNAs may be valuable for future determination of patient prognosis and could possibly serve as targets for miRNA-based therapies, which hold a great potential in the treatment of this severe malignant disease.
authors.affiliation: Laboratory for Cancer Biology, Institute of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 3B, 9220, Aalborg Ø, Denmark.
authors.forename: Michael
authors.initials: M
authors.lastname: Henriksen
authors.forename: Kasper Bendix
authors.initials: KB
authors.lastname: Johnsen
authors.forename: Hjalte Holm
authors.initials: HH
authors.lastname: Andersen
authors.forename: Linda
authors.initials: L
authors.lastname: Pilgaard
authors.forename: Meg
authors.initials: M
authors.lastname: Duroux
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018450:Disease Progression; D020869:Gene Expression Profiling; D005909:Glioblastoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D006801:Humans; D035683:MicroRNAs; D011379:Prognosis; D015996:Survival Rate
chemical_list: D035683:MicroRNAs