title: Expression analysis of programmed death ligand 2 in tumors caused by the avian oncovirus Marek's disease virus.
abstract: PD-L2 is a ligand of the immunoinhibitory receptor PD-1. Here, we report functional and expression analyses of PD-L2 in tumor lesions and spleens from chickens infected with gallid herpesvirus 2 (GaHV-2, Marek's disease virus), which induces malignant lymphomas in chickens. We show that the expression of IFN-γ protein was decreased in PBMCs and splenocytes co-cultured with PD-L2-expressing cells and that the expression of PD-L2 mRNA was significantly higher in the spleens of infected chickens in the latent phase and in tumor lesions caused by GaHV-2. These results suggest that chicken PD-L2 has an immunoinhibitory function and is involved in the establishment of latency and tumor formation by GaHV-2.
authors.affiliation: Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18, Nishi-9, Kita-ku, Sapporo, 060-0818, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Matsuyama-Kato
authors.forename: Shiro
authors.initials: S
authors.lastname: Murata
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Isezaki
authors.forename: Sarah
authors.initials: S
authors.lastname: Takasaki
authors.forename: Rika
authors.initials: R
authors.lastname: Kano
authors.forename: Satoru
authors.initials: S
authors.lastname: Konnai
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ohashi
mesh_terms: D000818:Animals; D002645:Chickens; D008381:Herpesvirus 2, Gallid / Q000235:genetics / Q000502:physiology*; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000821:virology; D008223:Lymphoma / Q000235:genetics / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D011201:Poultry Diseases / Q000235:genetics* / Q000276:immunology / Q000821:virology; D061027:Programmed Cell Death 1 Ligand 2 Protein / Q000235:genetics* / Q000276:immunology; D012190:Retroviridae / Q000235:genetics / Q000502:physiology; D013154:Spleen
chemical_list: D061027:Programmed Cell Death 1 Ligand 2 Protein