title: Morphological and pharmacological investigation on some biopotent materials derived from substituted pyrimidine and imidazole enzyme constituents.
abstract: Coordinating behavior of novel N2O type mixed ligand complexes (1-6) have been synthesized from substituted fluoropyrimidine [5-Fluorouracil (5-FU; A)] with biopotent imidazole enzyme constituents (B) viz., imidazole(him) and benzimidazole(bim) in the presence of Ni(II), Cu(II) and Zn(II) ions. Synthesized complexes were characterized by chemical analysis, spectral studies, magnetic moment and conductivity measurements. The results of chemical analysis and the observed low molar conductance values propose their stoichiometry to be 1:1:1 (M:A:B) with non-electrolytic nature. From the spectral data, it is inferred that the ligands A & B coordinate with M(II) ions in bi and monodentate approach through C(4)=O, N(3) and imidazole ring N(3) atoms respectively. The thermogravimetric analysis shows the dehydration, decomposition and thermal stability of mixed ligand complexes. XRD and SEM patterns show sharp crystalline peaks with homogeneous morphology. In vitro antimicrobial activities of free ligands (A & B) and their metal complexes were screened against some pathogenic strains by well diffusion technique. Absorption and gel electrophoresis experiments on the interaction of mixed ligand complexes with DNA suggest that all the complexes can bind as well as cleave the DNA by intercalation between chromophores and DNA base pairs. In addition, in vitro antioxidant activities were tested by DPPH free radical scavenging model.
authors.affiliation: Department of Chemistry, Division of Science and Humanities, Rajas International Institute of Technology for Women, Ozhuginaserri, Nagercoil 629 001, Tamil Nadu, India.
authors.forename: Sutha
authors.initials: S
authors.lastname: Shobana
authors.affiliation: Department of Chemistry and Research Centre, Aditanar College of Arts and Science, Virapandianpatnam, Thiruchendur 628 216, Thoothukudi District, Tamil Nadu, India. Electronic address: Subramaniam.perumal@gmail.com.
authors.forename: Perumal
authors.initials: P
authors.lastname: Subramaniam
authors.affiliation: Department of Chemistry, Division of Science and Humanities, Sree Sowdambika College of Engineering, Chettikurichi, Aruppukottai 626 134, Tamil Nadu, India.
authors.forename: Jeyapraksh
authors.initials: J
authors.lastname: Dharmaraja
authors.affiliation: Division of Science and Humanities, K.N.S.K. College of Engineering, Therekalputhoor, Nagercoil 629 001, Kanyakumari District, India.
authors.forename: Arvind
authors.initials: A
authors.lastname: Narayan
mesh_terms: D000818:Animals; D000963:Antimetabolites / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002417:Cattle; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000737:chemistry; D053837:DNA Cleavage / Q000187:drug effects; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology; D008024:Ligands; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000963:Antimetabolites; D000975:Antioxidants; D056831:Coordination Complexes; D007093:Imidazoles; D008024:Ligands; D011743:Pyrimidines; D003300:Copper; C029899:imidazole; D009532:Nickel; D004247:DNA; C427203:calf thymus DNA; D015032:Zinc; C030986:pyrimidine; D005472:Fluorouracil
keywords: DNA studies; Fluoropyrimidine; Imidazole enzyme constituents; Mixed ligand complexes; Pharmacological evaluation; Spectral studies