title: Efficient asymmetric hydrogenation of α-acetamidocinnamates through a simple, readily available monodentate chiral H-phosphinate.
abstract: An air-stable, simple (R(P))-mentylbenzylphosphinate, readily available in large quantities, can efficiently induce the rhodium-catalyzed asymmetric hydrogenation of α-acetamidocinnamates with high enantioselectivity (up to 99.6% ee). Intramolecular hydrogen bonding plays an important role in this asymmetric induction.
authors.affiliation: National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565 (Japan), Fax: (+81) 29-861-4855.
authors.forename: Xiang-Bo
authors.initials: XB
authors.lastname: Wang
authors.forename: Midori
authors.initials: M
authors.lastname: Goto
authors.forename: Li-Biao
authors.initials: LB
authors.lastname: Han
keywords: H-phosphinates; asymmetric catalysis; hydrogenation; rhodium