title: [Comparative analysis of morphofunctional indicators of peritoneal macrophages in mice of the cancer line A/SN and white outbred mice].
abstract: A study of the functional state of peritoneal macrophages was conducted of white outbred mice (W/o) which were resistant to cancer pathology as well as the mice of the A/sn line prone to development of cancer diseases. It was reveald that due to induction of aseptic inflammation ( induced by starch administration), chemotaxis of macrophages of the oncological line was 2.5-3 times reduced and capacity to adhesion was 1.5-2 times lower than capacity of macrophages of the control group (W/o). The paint on F-actin of cytoskeleton in cells showed that cells of the control group form filopodia as a result of adhesion to the substrate, during intercellular contacts as well as during macrophage incubation with retinoic acid. Macrophages A/sn can form pseudopodia when exposed to retinoic acid. Macrophages of both groups of mice were shown to be producer of endonucleases. The same activity of these enzymes was provided by the number of cells which was 1.5-2 times fewer in mice of the A/sn line.
authors.forename: S M
authors.initials: SM
authors.lastname: Miroshnichenko
authors.forename: G A
authors.initials: GA
authors.lastname: Kovalenko
authors.forename: N I
authors.initials: NI
authors.lastname: Tsirel'nikov
authors.forename: L E
authors.initials: LE
authors.lastname: Panin
mesh_terms: D000199:Actins / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D004720:Endonucleases / Q000096:biosynthesis*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D011554:Pseudopodia / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D000199:Actins; D000970:Antineoplastic Agents; D014212:Tretinoin; D004720:Endonucleases