title: Neurodegeneration with brain iron accumulation in an eleven-year-old jamaican male.
abstract: We present a case of an eleven-year-old boy presenting with progressive extrapyramidal signs and dementia. His imaging findings demonstrated the classic eye-of-the-tiger sign on T2W magnetic resonance imaging. He was diagnosed with pantothenate kinase-associated neurodegeneration (PKAN). This is a rare autosomal recessive inborn error of coenzyme A metabolism, caused by mutations in PANK2. This is the first reported case of PKAN from the Caribbean.
authors.affiliation: Department of Surgery, Radiology, Anaesthetics and Intensive Care, Faculty of Medical Sciences, University of the West Indies (Mona Campus), Kingston, Jamaica.
authors.forename: Peter
authors.initials: P
authors.lastname: Johnson
authors.affiliation: Department of Child and Adolescent Health, Faculty of Medical Sciences, University of the West Indies (Mona Campus), Kingston, Jamaica.
authors.forename: Roxanne
authors.initials: R
authors.lastname: Melbourne-Chambers
authors.affiliation: Department of Radiology and Imaging Sciences, Emory University School of Medicine, Emory University Hospital, BG21, 1364 Clifton Road, Atlanta, GA 30322, USA.
authors.forename: Nilesh
authors.initials: N
authors.lastname: Desai
authors.affiliation: Department of Child and Adolescent Health, Faculty of Medical Sciences, University of the West Indies (Mona Campus), Kingston, Jamaica.
authors.forename: Emma
authors.initials: E
authors.lastname: Greenaway