title: Fast and accurate fitting and filtering of noisy exponentials in Legendre space.
abstract: The parameters of experimentally obtained exponentials are usually found by least-squares fitting methods. Essentially, this is done by minimizing the mean squares sum of the differences between the data, most often a function of time, and a parameter-defined model function. Here we delineate a novel method where the noisy data are represented and analyzed in the space of Legendre polynomials. This is advantageous in several respects. First, parameter retrieval in the Legendre domain is typically two orders of magnitude faster than direct fitting in the time domain. Second, data fitting in a low-dimensional Legendre space yields estimates for amplitudes and time constants which are, on the average, more precise compared to least-squares-fitting with equal weights in the time domain. Third, the Legendre analysis of two exponentials gives satisfactory estimates in parameter ranges where least-squares-fitting in the time domain typically fails. Finally, filtering exponentials in the domain of Legendre polynomials leads to marked noise removal without the phase shift characteristic for conventional lowpass filters.
authors.affiliation: Department of Neurophysiology and Cellular Biophysics, University of Göttingen, Göttingen, Germany; DFG Cluster of Excellence 171, Göttingen, Germany.
authors.forename: Guobin
authors.initials: G
authors.lastname: Bao
authors.affiliation: Department of Neurophysiology and Cellular Biophysics, University of Göttingen, Göttingen, Germany; DFG Cluster of Excellence 171, Göttingen, Germany.
authors.forename: Detlev
authors.initials: D
authors.lastname: Schild
mesh_terms: D005583:Fourier Analysis; D013223:Statistics as Topic / Q000379:methods*; D013997:Time Factors