title: Prognostic criteria in colorectal carcinoma constructed by the combination of tumor-related and host-related factors.
abstract: BACKGROUND
  The significance of prognostic criteria based on a combination of tumor-related and host-related factors for patients with colorectal carcinoma has not been appreciated fully.
  
  
  METHODS
  Correlation of tumor-related and host-related score (TRHRS), which are constructed by the combination of serum elevation of C-reactive protein and pathologic lymph node metastasis (scores ranging 0 to 2), with clinicopathologic features including prognosis was studied in 271 patients with colorectal carcinoma who had been treated with curative resection.
  
  
  RESULTS
  Significant difference regarding survival was observed both between TRHRS 0 and 1 (P = .028) and between TRHRS 1 and 2 (P < .0001). Multivariate analysis showed that histologic types (P = .040) and TRHRS (P < .0001) were independent prognostic indicators.
  
  
  CONCLUSIONS
  Criteria for the prediction of prognosis in colorectal carcinoma treated with curative resection based on both tumor-related and host-related factors could provide a strict stratification.
authors.affiliation: Department of Surgery, Fukuoka Higashi Medical Center, 1-1-1 Chidori, Koga 811-3195, Japan. Electronic address: nozoet@fukuokae2.hosp.go.jp.
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Nozoe
authors.affiliation: Department of Surgery, Fukuoka Higashi Medical Center, 1-1-1 Chidori, Koga 811-3195, Japan.
authors.forename: Rumi
authors.initials: R
authors.lastname: Matono
authors.affiliation: Department of Surgery, Fukuoka Higashi Medical Center, 1-1-1 Chidori, Koga 811-3195, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ijichi
authors.affiliation: Department of Surgery, Fukuoka Higashi Medical Center, 1-1-1 Chidori, Koga 811-3195, Japan.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Ohga
authors.affiliation: Department of Surgery, Fukuoka Higashi Medical Center, 1-1-1 Chidori, Koga 811-3195, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ezaki
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D002288:Adenocarcinoma, Mucinous / Q000097:blood / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D002097:C-Reactive Protein
keywords: C-reactive protein; Colorectal carcinoma; Host-related factor; Lymph node metastasis; Prognostic indicator; Tumor-related factor