title: Elevated mitochondrial iron triggers doxorubicin-mediated cardiomyopathy.
abstract: Mitochondrial iron accumulation in the heart promotes doxorubicin-induced cardiotoxicity.
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D009202:Cardiomyopathies / Q000139:chemically induced*; D004317:Doxorubicin / Q000009:adverse effects*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007501:Iron / Q000378:metabolism*; D051379:Mice; D008928:Mitochondria / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D000970:Antineoplastic Agents; D017382:Reactive Oxygen Species; D004317:Doxorubicin; D007501:Iron