title: Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases.
abstract: Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their capability to emit phosphorescence in the kinase-bound state was established. Labelling of the inhibitors with a red fluorescent dye led to sensitive responsive photoluminescent probes for protein kinase CK2 that emitted red light with a long (microsecond-scale) decay time upon excitation of the probes with a pulse of near-UV light.
authors.affiliation: Institute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia. asko.uri@ut.ee.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Ekambaram
authors.forename: Erki
authors.initials: E
authors.lastname: Enkvist
authors.forename: Ganesh babu
authors.initials: Gb
authors.lastname: Manoharan
authors.forename: Mihkel
authors.initials: M
authors.lastname: Ugandi
authors.forename: Marje
authors.initials: M
authors.lastname: Kasari
authors.forename: Kaido
authors.initials: K
authors.lastname: Viht
authors.forename: Stefan
authors.initials: S
authors.lastname: Knapp
authors.forename: Olaf-Georg
authors.initials: OG
authors.lastname: Issinger
authors.forename: Asko
authors.initials: A
authors.lastname: Uri
mesh_terms: D001393:Azoles / Q000737:chemistry* / Q000528:radiation effects; D047390:Casein Kinase II / Q000737:chemistry*; D004396:Coloring Agents / Q000737:chemistry* / Q000528:radiation effects; D017868:Cyclic AMP-Dependent Protein Kinases / Q000737:chemistry; D008027:Light; D016566:Organoselenium Compounds / Q000737:chemistry* / Q000528:radiation effects; D010455:Peptides / Q000737:chemistry* / Q000528:radiation effects; D051573:Proto-Oncogene Proteins c-pim-1 / Q000737:chemistry
chemical_list: D001393:Azoles; D004396:Coloring Agents; D016566:Organoselenium Compounds; D010455:Peptides; D047390:Casein Kinase II; D051573:Proto-Oncogene Proteins c-pim-1; D017868:Cyclic AMP-Dependent Protein Kinases