title: Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase.
abstract: Ribonucleotide reductase (RNR), the rate-limiting enzyme in DNA synthesis, catalyzes reduction of the different ribonucleotides to their corresponding deoxyribonucleotides. The crucial role of RNR in DNA synthesis has made it an important target for the development of antiviral and anticancer drugs. Taking account of the recent developments in this field of research, this review focuses on the role of thioredoxin and glutaredoxin systems in the redox reactions of the RNR catalysis.
authors.affiliation: Rajib Sengupta, Arne Holmgren, Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE-17177 Stockholm, Sweden.
authors.forename: Rajib
authors.initials: R
authors.lastname: Sengupta
authors.affiliation: Rajib Sengupta, Arne Holmgren, Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE-17177 Stockholm, Sweden.
authors.forename: Arne
authors.initials: A
authors.lastname: Holmgren
keywords: DNA synthesis; Glutaredoxin; Replication; Ribonucleotide reductase; Thiol disulfides; Thioredoxin