title: Type 2 diabetes mellitus-related genetic polymorphisms in microRNAs and microRNA target sites.
abstract: MicroRNAs (miRNAs) are important endogenous regulators in eukaryotic gene expression and a broad range of biological processes. MiRNA-related genetic variations have been proved to be associated with human diseases, such as type 2 diabetes mellitus (T2DM). Polymorphisms in miRNA genes (primary miRNAs, precursor miRNAs, mature miRNAs, and miRNA regulatory regions) may be involved in the development of T2DM by changing the expression and structure of miRNAs and target gene expression. Genetic polymorphisms of the 3'-untranslated region (UTR) in miRNA target genes may destroy putative miRNA binding sites or create new miRNA binding sites, which affects the binding of UTRs with miRNAs, finally resulting in susceptibility to and development of T2DM. Therefore, focusing on studies into genetic polymorphisms in miRNAs or miRNA binding sites will help our understanding of the pathophysiology of T2DM development and lead to better health management. Herein, we review the association of genetic polymorphisms in miRNA and miRNA targets genes with T2DM development.
authors.affiliation: Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, China; Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Weijing
authors.initials: W
authors.lastname: Gong
authors.forename: Di
authors.initials: D
authors.lastname: Xiao
authors.forename: Guangfeng
authors.initials: G
authors.lastname: Ming
authors.forename: Jiye
authors.initials: J
authors.lastname: Yin
authors.forename: Honghao
authors.initials: H
authors.lastname: Zhou
authors.forename: Zhaoqian
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D001665:Binding Sites; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger
keywords: genetic polymorphism; microRNA; microRNA target sites; type 2 diabetes mellitus; 基因多态性，miRNA靶位，miRNA，2型糖尿病