title: Association between CD95L polymorphism and cervical cancer risk: evidence from a meta-analysis.
abstract: Several studies have assessed the association of CD95L polymorphism with cervical cancer risk, but the data lack the power to provide compelling evidence. In this study, we aimed to clarify the association through a meta-analysis. A comprehensive search was conducted in PubMed, Embase, and Web of Science. The fixed-effects model was used to calculate odds ratio (OR) with 95 % confidence intervals (CIs). A total of five papers with six case-control studies were derived and finally included in this meta-analysis. The overall estimate did not reveal any significant association between CD95L -844C/T polymorphism and cervical cancer risk. Subgroup analysis in Asian population indicated nonsignificant nevertheless potentially increased risk in CC genotype carriers in comparison with the carriers of CT+TT genotypes (ORCC vs. CT+TT=1.16, 95 % CI=0.99-1.36, P for heterogeneity=0.231). Based on current epidemiological studies, this meta-analysis suggests that CD95L polymorphism may not be a risk factor contributing to cervical cancer development.
authors.affiliation: Department of Gynaecology and Obstetrics, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Lu
authors.forename: Xiang
authors.initials: X
authors.lastname: Cheng
authors.forename: Rongkai
authors.initials: R
authors.lastname: Xie
authors.forename: Zhengqiong
authors.initials: Z
authors.lastname: Chen
authors.forename: Youfei
authors.initials: Y
authors.lastname: Li
authors.forename: Guilan
authors.initials: G
authors.lastname: Lin
authors.forename: Jianmei
authors.initials: J
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
mesh_terms: D016022:Case-Control Studies; D053222:Fas Ligand Protein / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D012306:Risk; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000235:genetics*
chemical_list: D053222:Fas Ligand Protein