title: Periodontal ligament stem cells: an update and perspectives.
abstract: Chronic periodontitis is a serious infectious and inflammatory oral disease of humans worldwide. Conventional treatment modalities are effective for controlling periodontal disease. However, the regeneration of damaged periodontal tissues remains a major challenge in clinical practice due to the complex structure of the periodontium. Stem cell-based regenerative approaches combined with the usage of emerging biomaterials are entering a new era in periodontal regeneration. The present review updates the current knowledge of periodontal ligament stem cell-based approaches for periodontal regeneration, and elaborates on the potentials for clinical application.
authors.affiliation: Department of Comprehensive Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
authors.forename: P K
authors.initials: PK
authors.lastname: Chamila Prageeth Pandula
authors.forename: L P
authors.initials: LP
authors.lastname: Samaranayake
authors.forename: L J
authors.initials: LJ
authors.lastname: Jin
authors.forename: Chengfei
authors.initials: C
authors.lastname: Zhang
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use; D055113:Chronic Periodontitis / Q000628:therapy; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D039902:Multipotent Stem Cells / Q000502:physiology; D010513:Periodontal Ligament / Q000166:cytology*; D013234:Stem Cells / Q000502:physiology*; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials
keywords: chronic periodontitis; periodontal disease; periodontal ligament stem cells; regeneration; tissue engineering