title: Cardiac effects of vasopressin.
abstract: Vasopressin is an essential hormone involved in the maintenance of cardiovascular homeostasis. It has been in use therapeutically for many decades, with an emphasis on its vasoconstrictive and antidiuretic properties. However, this hormone has a ubiquitous influence and has specific effects on the heart. Although difficult to separate from its powerful vascular effects in the clinical setting, a better understanding of vasopressin's direct cardiac effects could lead to its more effective clinical use for a variety of shock states by maximizing its therapeutic benefit. The cardiac-specific effects of vasopressin are complex and require further elucidation. Complicating our understanding include the various receptors and secondary messengers involved in vasopressin's effects, which may lead to various results based on differing doses and varying environmental conditions. Thus, there have been contradictory reports on vasopressin's action on the coronary vasculature and on its effect on inotropy. However, beneficial results have been found and warrant further study to expand the potential therapeutic role of vasopressin. This review outlines the effect of vasopressin on the coronary vasculature, cardiac contractility, and on hypertrophy and cardioprotection. These cardiac-specific effects of vasopressin represent an interesting area for further study for potentially important therapeutic benefits.
authors.affiliation: Departments of *Surgery; and †Pediatrics, University of Alberta, Edmonton, Canada.
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Pelletier
authors.forename: Bryan
authors.initials: B
authors.lastname: Dicken
authors.forename: David
authors.initials: D
authors.lastname: Bigam
authors.forename: Po-Yin
authors.initials: PY
authors.lastname: Cheung
mesh_terms: D000818:Animals; D050034:Antidiuretic Agents / Q000494:pharmacology; D006332:Cardiomegaly / Q000188:drug therapy / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects* / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014667:Vasopressins / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D050034:Antidiuretic Agents; D014662:Vasoconstrictor Agents; D014667:Vasopressins