title: Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation.
abstract: The extracellular matrix polysaccharide hyaluronan (HA) exerts size-dependent effects on leukocyte behavior. Low-molecular weight HA is abundant at sites of active tissue catabolism and promotes inflammation via effects on Toll-like receptor signaling. Conversely, high-molecular weight HA is prevalent in uninjured tissues and is anti-inflammatory. We propose that the ability of high-molecular weight but not low-molecular weight HA to cross-link CD44 functions as a novel form of pattern recognition that recognizes intact tissues and communicates "tissue integrity signals" that promote resolution of local immune responses.
authors.affiliation: Division of Infectious Diseases, Stanford University School of Medicine, 300 Pasteur Drive, Rm. L-133, Stanford, CA, 94305-5107, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Ruppert
authors.forename: T R
authors.initials: TR
authors.lastname: Hawn
authors.forename: A
authors.initials: A
authors.lastname: Arrigoni
authors.forename: T N
authors.initials: TN
authors.lastname: Wight
authors.forename: P L
authors.initials: PL
authors.lastname: Bollyky
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D006820:Hyaluronic Acid / Q000737:chemistry / Q000378:metabolism*; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism*; D008970:Molecular Weight; D011485:Protein Binding; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018960:Hyaluronan Receptors; D051192:Receptors, Pattern Recognition; D006820:Hyaluronic Acid