title: PAS-positive extracellular deposits within germinal centers of hyperplastic follicles during SIV infection in a rhesus macaque.
abstract: BACKGROUND
  Lymphoid tissue remodeling is characteristic of chronic simian immunodeficiency virus infection.
  
  
  METHODS
  A rhesus macaque infected with SIVmac239 was necropsied and its lymphoid tissues subjected to histopathology characterization.
  
  
  RESULTS
  Germinal centers in spleen and lymph nodes contained PAS-positive, non-amyloid extracellular deposits, decreased T follicular helper cells, and normal density of Ki67(+) B cells.
  
  
  CONCLUSIONS
  A possible mechanism for PAS-positive deposits includes exaggerated involution of SIV-induced follicular hyperplasia secondary to virus-associated immune reaction.
authors.affiliation: Division of Pathology, Yerkes National Primate Research Center, Atlanta, GA, USA.
authors.forename: Jung Joo
authors.initials: JJ
authors.lastname: Hong
authors.forename: Francois
authors.initials: F
authors.lastname: Villinger
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Courtney
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D018858:Germinal Center / Q000276:immunology / Q000648:ultrastructure* / Q000821:virology; D008198:Lymph Nodes / Q000473:pathology / Q000648:ultrastructure; D008221:Lymphoid Tissue / Q000473:pathology / Q000648:ultrastructure; D008253:Macaca mulatta; D008297:Male; D008854:Microscopy, Electron; D010503:Periodic Acid-Schiff Reaction; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013154:Spleen / Q000473:pathology / Q000648:ultrastructure; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
keywords: Macaca mulatta; T follicular helper cells; lymph node; non-amyloid; spleen