title: Leukocytoclastic vasculitis as a complication of recombinant granulocyte colony-stimulating factor therapy in a heart transplant patient.
abstract: Recombinant granulocyte colony-stimulating factor (rG-CSF) is a myeloid growth factor that is widely used in haematology to recover neutropenia secondary to myelosuppressive chemotherapy. Leukocytoclastic vasculitis is an acknowledged side effect of the above therapy. Its pathogenesis involves many mechanisms that collectively induce an increase in neutrophil function and a subsequent release of cytokines. Here, we report a case of leukocytoclastic vasculitis proven by skin biopsy, following the use of rG-CSF in a heart transplant patient with leukopenia secondary to immunosuppressive therapy.
authors.affiliation: U.O Medicina Interna, Policlinico di Monza, Via C. Amati 111, 20900 Monza, Italy ; Division of Cardiac Surgery, University of Pavia School of Medicine, Foundation "I.R.C.C.S. San Matteo" Hospital, Pavia, Italy.
authors.forename: Giovanbattista
authors.initials: G
authors.lastname: Ippoliti
authors.affiliation: Anatomic Pathology, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Paulli
authors.affiliation: Anatomic Pathology, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Lucioni
authors.affiliation: U.O Medicina Interna, Policlinico di Monza, Via C. Amati 111, 20900 Monza, Italy.
authors.forename: Marinella
authors.initials: M
authors.lastname: Lauriola
authors.affiliation: Division of Cardiac Surgery, University of Pavia School of Medicine, Foundation "I.R.C.C.S. San Matteo" Hospital, Pavia, Italy.
authors.forename: Andrea Maria
authors.initials: AM
authors.lastname: D'Armini