title: Plasma cell myeloma with unusual morphology--a series of 6 cases.
abstract: Morphological variants of plasma cells have been described in cases of Plasma cell neoplasm. Presence of these atypical forms poses difficulty in morphological diagnosis and demands the use of ancillary techniques to ascertain the nature of these atypical cells. We hereby report a series of 6 such cases where the bone marrow examination showed plasma cells with atypical morphology, leading to varied differential diagnosis; however immunophenotyping by flow cytometry in adjunct to serum electrophoresis, immunofixation and free light chain assays confirmed the diagnosis.
authors.affiliation: Department of Hematology, SGPGIMS, Lucknow, India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Gupta
authors.forename: Naushad
authors.initials: N
authors.lastname: Hussain
authors.forename: Khaliqur
authors.initials: K
authors.lastname: Rahman
authors.forename: Soniya
authors.initials: S
authors.lastname: Nityanand
mesh_terms: D015746:Abdominal Pain / Q000473:pathology / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000740:Anemia / Q000473:pathology / Q000503:physiopathology; D001853:Bone Marrow / Q000473:pathology*; D001856:Bone Marrow Examination; D003937:Diagnosis, Differential; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000097:blood; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000473:pathology* / Q000503:physiopathology; D010950:Plasma Cells / Q000473:pathology*
chemical_list: D007147:Immunoglobulin Light Chains
keywords: atypical plasma cell morphology; immunophenotyping by flow cytometry