title: Olfactory sulcus morphology in established bipolar affective disorder.
abstract: This MRI study examined the morphology of the olfactory sulcus, a potential marker of early neurodevelopment in 26 patients with bipolar I disorder and 24 matched controls. Bipolar patients had significantly shallower olfactory sulci bilaterally compared to controls, suggesting that neurodevelopmental abnormalities contribute to the neurobiology of bipolar disorder.
authors.affiliation: Department of Neuropsychiatry, University of Toyama, Toyama, Japan. Electronic address: tsutomu@med.u-toyama.ac.jp.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Discipline of Psychological Medicine, Northern Clinical School, University of Sydney, Sydney, NSW, Australia; CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Sydney, NSW, Australia.
authors.forename: Gin S
authors.initials: GS
authors.lastname: Malhi
authors.affiliation: Department of Neuropsychiatry, University of Toyama, Toyama, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Department of Neuropsychiatry, University of Toyama, Toyama, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne, VIC, Australia.
authors.forename: Christos
authors.initials: C
authors.lastname: Pantelis
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009833:Olfactory Pathways / Q000473:pathology*; D009929:Organ Size
keywords: Bipolar disorder; Magnetic resonance imaging; Neurodevelopment