title: The Canine Orthopedic Index. Step 3: Responsiveness testing.
abstract: OBJECTIVE
  To determine whether the Canine Orthopedic Index (COI) can detect changes in dogs with osteoarthritis (OA) treated with either non-steroidal anti-inflammatory drugs (NSAID) or placebo.
  
  
  METHODS
  Double blind randomized placebo controlled trial.
  
  
  METHODS
  Dogs (n = 80) with OA.
  
  
  METHODS
  Owners completed the COI on Day 0. Dogs were administered either carprofen or placebo on days 1 through 14. Owners completed the COI again on Day 14. The change in total instrument, stiffness, gait, function, and quality of life scores were assessed between groups.
  
  
  RESULTS
  Dogs administered carprofen had significant decreases in the total instrument score (P = .002) as well as 3 of the 4 factor scores compared to dogs treated with placebo (stiffness score P = .015; gait score P = .001; and function score = 0.008). The change in quality of life score was not significantly different between carprofen and placebo treated dogs (P = .124).
  
  
  CONCLUSIONS
  The COI delivered the decreases in total instrument, stiffness, gait, and function scores that one would expect in dogs with OA treated with an NSAID compared with placebo administration. In this cohort of dogs, the quality of life score was not sensitive to the changes associated with NSAID administration.
authors.affiliation: Veterinary Clinical Investigations Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Dorothy Cimino
authors.initials: DC
authors.lastname: Brown
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D015331:Cohort Studies; D003625:Data Collection; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D006801:Humans; D019637:Orthopedic Procedures / Q000592:standards / Q000662:veterinary*; D010003:Osteoarthritis / Q000188:drug therapy / Q000662:veterinary*; D063868:Patient Outcome Assessment; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; C007005:carprofen