title: Regional gray matter volume and anxiety-related traits interact to predict somatic complaints in a non-clinical sample.
abstract: Somatic complaints can be important features of an individual's expression of anxiety. Anxiety-related traits are also risk factors for somatic symptoms. However, it is not known which neuroanatomical mechanisms may be responsible for this relationship. In this study, our first step was to use voxel-based morphometry (VBM) approaches to investigate the neuroanatomical basis underlying somatic complaints in a large sample of healthy subjects. We found a significant positive correlation between somatic complaints and parahippocampal gyrus (PHG) volume adjacent to the entorhinal cortex. Further analysis revealed that the interaction between PHG volume/entorhinal cortex and neuroticism-anxiety (N-Anx) predicted somatic complaints. Specifically, somatic complaints were associated with higher N-Anx for individuals with increased PHG volume. These findings suggest that increased PHG volume and higher trait anxiety can predict vulnerability to somatic complaints in the general population.
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Dongtao
authors.initials: D
authors.lastname: Wei
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Wenfu
authors.initials: W
authors.lastname: Li
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Qunlin
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Haijiang
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Hao
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Glenn
authors.initials: G
authors.lastname: Hitchman
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Qinglin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China and Department of Psychology, Southwest University, Chongqing 400715, China qiuj318@swu.edu.cn.
authors.forename: Jiang
authors.initials: J
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000473:pathology* / Q000523:psychology*; D018728:Entorhinal Cortex / Q000473:pathology; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009497:Neurotic Disorders / Q000473:pathology / Q000523:psychology; D020534:Parahippocampal Gyrus / Q000473:pathology; D010551:Personality; D013001:Somatoform Disorders / Q000473:pathology* / Q000523:psychology*; D055815:Young Adult
keywords: anxiety; neuroticism; somatic complaints; somatization; voxel-based morphometry (VBM)