title: FTO genotype, physical activity, and coronary heart disease risk in Swedish men and women.
abstract: BACKGROUND
  Variants in the fat mass- and obesity-associated gene (FTO) predisposing to obesity and diabetes mellitus have also been associated with cardiovascular disease. Physical activity has been suggested to attenuate the FTO effect on obesity, but it is unknown whether this is also true for cardiovascular disease. Therefore, we explored whether physical activity modifies the FTO association with coronary heart disease (CHD).
  
  
  RESULTS
  FTO rs9939609 (T>A) polymorphism was genotyped in 2 Swedish population-based case-control studies with 1743 CHD cases and 4402 population controls (25-74 years of age; 41% women). Leisure time physical activity was assessed by questionnaires, and 3 levels were defined: low, medium, and high. Overall, carriers of the FTO A allele had an increased risk of CHD (odds ratio, 1.20; 95% confidence interval, 1.06-1.37) adjusted for age, sex, study, and body mass index. Although A-allele carriers with low physical activity had the highest CHD risk (odds ratio, 3.30; 95% confidence interval, 2.44-4.46) compared with those with TT genotype and high activity, the effects of FTO genotype and physical activity on CHD risk were approximately additive, indicating the absence of additive interaction. The stratum-specific relative risks of CHD from the A allele in subjects with low, medium, and high physical activity were odds ratio 1.11 (95% confidence interval, 0.77-1.60), 1.22 (1.04-1.44), and 1.38 (1.06-1.80), respectively, but the suggested multiplicative interaction was not significant.
  
  
  CONCLUSIONS
  FTO rs9939609 A-allele carriers have an increased CHD risk, and the association is not counteracted by increased physical activity.
authors.affiliation: Occupational and Environmental Medicine.
authors.forename: Jaana
authors.initials: J
authors.lastname: Gustavsson
authors.forename: Kirsten
authors.initials: K
authors.lastname: Mehlig
authors.forename: Karin
authors.initials: K
authors.lastname: Leander
authors.forename: Lauren
authors.initials: L
authors.lastname: Lissner
authors.forename: Lena
authors.initials: L
authors.lastname: Björck
authors.forename: Annika
authors.initials: A
authors.lastname: Rosengren
authors.forename: Fredrik
authors.initials: F
authors.lastname: Nyberg
mesh_terms: D000328:Adult; D000368:Aged; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D013548:Sweden / Q000453:epidemiology; D044465:White People / Q000235:genetics* / Q000523:psychology
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: coronary disease; molecular epidemiology; motor activity