title: Latent TB infection diagnosis in population exposed to TB subjects in close and poor ventilated high TB endemic zone in India.
abstract: BACKGROUND
  The present study was designed to investigate the utility of Quantiferon TB gold (QFT-G) and Tuberculin skin test (TST) for diagnosis of latent TB infection (LTBI) in high crowding TB endemic zone of Nagpur, India and their comparison with associated risk factors.
  
  
  METHODS
  Out of 342 eligible participants, QFT-G and TST were performed in 162 participants.
  
  
  RESULTS
  The prevalence of LTBI observed according to QFT-G and TST was 48% and 42% respectively, with an agreement of 52.47%. QFT-G positivity was associated with age while TST positivity was associated with body mass index (BMI). Duration of exposure emerged as a key risk factor significantly associated with both the tests.
  
  
  CONCLUSIONS
  The prevalence of LTBI was quite high in the studied zone as detected by both the evaluated tests and thus, the combination of both the tests will be best predictive for LTBI in such high TB endemic regions.
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India.
authors.forename: Rajpal S
authors.initials: RS
authors.lastname: Kashyap
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India.
authors.forename: Amit R
authors.initials: AR
authors.lastname: Nayak
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India.
authors.forename: Hari M
authors.initials: HM
authors.lastname: Gaherwar
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India.
authors.forename: Aliabbas A
authors.initials: AA
authors.lastname: Husain
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India.
authors.forename: Seema D
authors.initials: SD
authors.lastname: Shekhawat
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India.
authors.forename: Ruchika K
authors.initials: RK
authors.lastname: Jain
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India.
authors.forename: Milind S
authors.initials: MS
authors.lastname: Panchbhai
authors.affiliation: MDS Bio-Analytics Pvt. Ltd, Nagpur, Maharashtra, India.
authors.forename: Dhananjay V
authors.initials: DV
authors.lastname: Raje
authors.affiliation: Environmental Genomic Unit, National Environmental Engineering Research Institute, Nagpur, Maharashtra, India.
authors.forename: Hemant J
authors.initials: HJ
authors.lastname: Purohit
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India.
authors.forename: Girdhar M
authors.initials: GM
authors.lastname: Taori
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India.
authors.forename: Hatim F
authors.initials: HF
authors.lastname: Daginawala
mesh_terms: D000293:Adolescent; D000328:Adult; D019353:Endemic Diseases / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India / Q000453:epidemiology; D007371:Interferon-gamma; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D014374:Tuberculin Test; D014691:Ventilation; D055815:Young Adult
chemical_list: D007371:Interferon-gamma