title: [Severe osteoarticular infections with Staphylococcus aureus producer of Panton-Valentine Leukocidine in children].
abstract: Emerging strain of Stapylococcus aureus (S. aureus) producer of the Panton-Valentine Leukocidine (PVL+) are becoming a new issue in public health. Those bacteria are accountable for serious cutaneous infection with a necrotic evolution, necrotizing pneumonia and severe osteoarticular infection. These last infections can be life-threatening and are at high risk of complications. Therefore, a multidisciplinary approach is necessary, in addition with an aggressive chirurgical treatment. We are here reporting 3 cases of osteoarticular infections by S. aureus PVL+ sensitive to methicilline, which illustrate the difficulties encountered in the management and treatment, as well as the potential for serious orthopedics complications.
authors.forename: Clémence
authors.initials: C
authors.lastname: Didisheim
authors.forename: Victor
authors.initials: V
authors.lastname: Dubois-Ferrière
authors.forename: Amira
authors.initials: A
authors.lastname: Dhouib
authors.forename: Pierre
authors.initials: P
authors.lastname: Lascombes
authors.forename: Abdessalam
authors.initials: A
authors.lastname: Cherkaoui
authors.forename: Gesuele
authors.initials: G
authors.lastname: Renzi
authors.forename: Patrice
authors.initials: P
authors.lastname: François
authors.forename: Jacques
authors.initials: J
authors.lastname: Schrenzel
authors.forename: Dimitri
authors.initials: D
authors.lastname: Ceroni
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000096:biosynthesis*; D002648:Child; D005098:Exotoxins / Q000096:biosynthesis*; D005260:Female; D005436:Floxacillin / Q000627:therapeutic use; D006801:Humans; D007592:Joint Diseases / Q000188:drug therapy / Q000382:microbiology*; D007956:Leukocidins / Q000096:biosynthesis*; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000188:drug therapy; D013211:Staphylococcus aureus
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D005436:Floxacillin