title: Pregnancy in a woman with premature ovarian insufficiency associated with blepharophimosis, ptosis, epicanthus inversus syndrome type I. A case report.
abstract: BACKGROUND
  Blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) type I is a rare disorder that causes a recognizable pattern of eye abnormalities and is associated with premature ovarian insufficiency. There is no data to guide the treatment of these patients when presenting with infertility.
  
  
  METHODS
  A 30-year-old, nulligravid woman with premature ovarian insufficiency associated with BPES type I presented to care secondary to a desire to conceive. Ovarian stimulation with gonadotropins was performed, and the patient conceived and delivered viable twins.
  
  
  CONCLUSIONS
  It is not known whether premature ovarian insufficiency associated with BPES type I follows the same clinical course as idiopathic premature ovarian insufficiency. In patients with BPES type I who present with infertility, ovarian stimulation with gonadotropins may be a reasonable therapeutic option.
authors.affiliation: Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado 80045, USA. lauren.roth@ucdenver.edu
authors.forename: Lauren W
authors.initials: LW
authors.lastname: Roth
authors.affiliation: Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado 80045, USA.
authors.forename: Ruben
authors.initials: R
authors.lastname: Alvero
mesh_terms: D000328:Adult; D016569:Blepharophimosis / Q000150:complications*; D001763:Blepharoptosis; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004370:Duane Retraction Syndrome / Q000150:complications*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007316:Insemination, Artificial, Heterologous; D008297:Male; D010062:Ovulation Induction; D011247:Pregnancy; D011248:Pregnancy Complications; D011272:Pregnancy, Multiple; D011994:Recombinant Proteins; D014427:Twins
chemical_list: D006063:Chorionic Gonadotropin; D011994:Recombinant Proteins; D005640:Follicle Stimulating Hormone