title: Axon guidance: FLRTing promotes attraction.
abstract: A recent study demonstrates a new mechanism by which crosstalk between multiple guidance cues is integrated during axon pathfinding. FLRT3 is a novel co-receptor for Robo1 that acts as a context-dependent modulator of Netrin-1 attraction in thalamocortical axons.
authors.affiliation: Department of Biology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA. Electronic address: laura.lowery@bc.edu.
authors.forename: Laura Anne
authors.initials: LA
authors.lastname: Lowery
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D000075388:Netrin-1; D011971:Receptors, Immunologic / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D000097905:Roundabout Proteins
chemical_list: D008562:Membrane Glycoproteins; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D000075388:Netrin-1; D011971:Receptors, Immunologic; D025521:Tumor Suppressor Proteins; D000097905:Roundabout Proteins; C514260:FLRT3 protein, mouse; C000617353:Ntn1 protein, mouse