title: Tandem halogenation/Michael-initiated ring-closing reaction of α,β-unsaturated nitriles and activated methylene compounds: one-pot diastereoselective synthesis of functionalized cyclopropanes.
abstract: An efficient one-pot synthetic route to highly substituted cyclopropanes has been developed from readily available α,β-unsaturated nitriles and doubly activated methylene compounds under very mild conditions in a highly diastereoselective manner, which involves halogenation, Michael addition and intramolecular ring-closing reaction sequences.
authors.affiliation: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. yjliang@ciac.ac.cn dwdong@ciac.ac.cn.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Xin
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yongjiu
authors.initials: Y
authors.lastname: Liang
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Dewen
authors.initials: D
authors.lastname: Dong
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry*; D054879:Halogenation; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D003521:Cyclopropanes; D009570:Nitriles