title: Is DNA methylation of tumour suppressor genes epigenetic?
abstract: In colorectal cancer cells, a non-epigenetic transcriptional pathway that is mediated by an oncogene maintains DNA methylation of tumour suppressor genes.
authors.affiliation: Kevin Struhl is an eLife reviewing editor, and is in the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States kevin_struhl@hms.harvard.edu.
authors.forename: Kevin
authors.initials: K
authors.lastname: Struhl
mesh_terms: D000818:Animals; D018899:CpG Islands; D019175:DNA Methylation; D020868:Gene Silencing; D011905:Genes, ras; D006801:Humans; D014158:Transcription, Genetic
keywords: CpG island methylator phenotype; DNMT1; INK4-ARF; KRAS; ZNF304; colorectal cancer