title: Large cell calcifying sertoli cell tumor of the testis: a case study and review of the literature.
abstract: A 24-year-old man was admitted due to an incidentally detected mass in his left testis, which showed radiopaque calcification on plain X-ray film. Left orchiectomy was performed, and the resected testis contained a well-demarcated, hard mass measuring 1.1 cm. Histological analysis revealed that the tumor was composed of neoplastic cells, fibrotic stroma, and laminated or irregularly shaped calcific bodies. The individual cells had abundant eosinophilic or clear cytoplasm with round nuclei, each of which contained one or two conspicuous nucleoli. They were arranged in cords, trabeculae, clusters, and diffuse sheets. There were several foci of intra-tubular growth patterns, with thickening of the basal lamina. Immunohistochemically, the neoplastic cells were positive for S-100 protein and vimentin, focally positive for inhibin alpha, and negative for cytokeratin, CD10, and Melan-A. In addition to reporting this rare case, we also review the relevant literature regarding large cell calcifying Sertoli cell tumors.
authors.affiliation: Department of Pathology, The Armed Forces Capital Hospital, Seongnam, Korea.
authors.forename: Dae Hyun
authors.initials: DH
authors.lastname: Song
authors.affiliation: Department of Pathology, The Armed Forces Capital Hospital, Seongnam, Korea.
authors.forename: Seong Muk
authors.initials: SM
authors.lastname: Jeong
authors.affiliation: Department of Urology, The Armed Forces Capital Hospital, Seongnam, Korea.
authors.forename: Jong Tak
authors.initials: JT
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, The Armed Forces Capital Hospital, Seongnam, Korea.
authors.forename: Gak Won
authors.initials: GW
authors.lastname: Yun
authors.affiliation: Department of Pathology and Human Genome Research Institute, Green Cross Reference Laboratory, Yongin, Korea.
authors.forename: Byoung Kwon
authors.initials: BK
authors.lastname: Kim
authors.affiliation: Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Jong Sil
authors.initials: JS
authors.lastname: Lee
keywords: Immunohistochemistry; Sertoli cell tumor; Testis