title: Scaffolding Catalysis: Expanding the Repertoire of Bifunctional Catalysts.
abstract: Inducing an intramolecular reaction is a powerful means of accelerating reactions. Though this mechanism of catalysis is common in enzymes, it is underutilized in synthetic catalysts. This article outlines our group's recent efforts to use reversible covalent bonding to induce an intramolecular reaction, allowing for rate acceleration as well as control of the selectivity in the desymmetrization of 1,2-diols.
authors.affiliation: Department of Chemistry, Boston College, 2609 Beacon St., Chestnut Hill, MA 02467, USA.
authors.forename: Kian L
authors.initials: KL
authors.lastname: Tan
authors.affiliation: Department of Chemistry, Boston College, 2609 Beacon St., Chestnut Hill, MA 02467, USA.
authors.forename: Xixi
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Chemistry, Boston College, 2609 Beacon St., Chestnut Hill, MA 02467, USA.
authors.forename: Amanda D
authors.initials: AD
authors.lastname: Worthy
keywords: asymmetric catalysis; desymmetrization; diols; enantioselectivity; organocatalysis