title: Palladium-catalyzed decarboxylative trifluoroethylation of aryl alkynyl carboxylic acids.
abstract: A trifluoroethylation of alkynes through a palladium-catalyzed decarboxylative coupling reaction was developed. When alkynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(η(3)-allyl)Cl]2/XantPhos and Cs2CO3 in N,N-dimethylformamide (DMF) at 80 °C for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group tolerance.
authors.affiliation: Department of Chemistry, Chonnam National University , Gwangju 500-757, Republic of Korea.
authors.forename: Jinil
authors.initials: J
authors.lastname: Hwang
authors.forename: Kyungho
authors.initials: K
authors.lastname: Park
authors.forename: Juseok
authors.initials: J
authors.lastname: Choe
authors.forename: Hongkeun
authors.initials: H
authors.lastname: Min
authors.forename: Kwang Ho
authors.initials: KH
authors.lastname: Song
authors.forename: Sunwoo
authors.initials: S
authors.lastname: Lee
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D002586:Cesium / Q000737:chemistry*; D004126:Dimethylformamide / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D002254:Carbonates; D002264:Carboxylic Acids; D006845:Hydrocarbons, Fluorinated; D002586:Cesium; D010165:Palladium; D004126:Dimethylformamide; C545311:cesium carbonate