title: Inhibitory effects of resveratrol on melanin synthesis in ultraviolet B-induced pigmentation in Guinea pig skin.
abstract: Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits α-melanocyte-stimulating hormone signaling, viability, and migration in melanoma cells. However, these effects have not been confirmed in vivo, specifically brownish guinea pigs. To evaluate the potential of resveratrol as a regulator of melanin for hyperpigmentation therapy, the influence of resveratrol on pigmentation was investigated by ultraviolet B-induced hyperpigmentation in brownish guinea pig skin. We found that resveratrol reduced the expression of melanogenesis-related proteins tyrosinase, tyrosinase-related proteins 1 and 2, and microphthalmia-associated transcription factor in melanoma cells. Furthermore, topical application of resveratrol was demonstrated to significantly decrease hyperpigmentation on ultraviolet B-stimulated guinea pig skin in vivo. Based on our histological data, resveratrol inhibits melanin synthesis via a reduction in tyrosinase-related protein 2 among the melanogenic enzymes. This study is the first to provide evidence supporting resveratrol as a depigmentation agent, along with further clinical investigation of resveratrol in ultraviolet B-induced skin disorders such as hyperpigmentation and skin photoaging.
authors.affiliation: College of Pharmacy, Yonsei University, Incheon 406-840.
authors.forename: Taek Hwan
authors.initials: TH
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Gachon University, Incheon 406-799.
authors.forename: Jae Ok
authors.initials: JO
authors.lastname: Seo
authors.affiliation: National Institute of Crop Science, Rural Development Administration, Iksan 570-080.
authors.forename: So-Hyeon
authors.initials: SH
authors.lastname: Baek
authors.affiliation: College of Pharmacy, Gachon University, Incheon 406-799 ; Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 406-799 ; Gachon Medical Research Institute, Gil Medical Center, Inchon 405-760, Republic of Korea.
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
keywords: Depigmentation; Guinea pig; Hyperpigmentation; Melanogenesis; Resveratrol; Ultraviolet B