title: Genetic variants determining body fat distribution and sex hormone-binding globulin among Chinese female young adults.
abstract: BACKGROUND
  Measures of body fat distribution (i.e. waist : hip ratio [WHR]) are major risk factors for diabetes, independent of overall adiposity. The genetic variants related to body fat distribution show sexual dimorphism and particularly affect females. Substantial literature supports a role for sex hormone-binding globulin (SHBG) in the maintenance of glucose homeostasis. The aim of the present study was to examine the association of the genetic risk score of body fat distribution with SHBG levels and insulin resistance in young (14-30 years) Chinese females.
  
  
  METHODS
  In all, 675 young Chinese females were evaluated in the present study. A genetic risk score (GRS) was calculated on the basis of 12 established variants associated with body fat distribution. The main outcome variable was serum SHBG levels and homeostasis model assessment of insulin resistance (HOMA-IR).
  
  
  RESULTS
  The GRS of body fat distribution was significantly associated with decreasing serum SHBG levels (P = 0.018), independent of body mass index and WHR. In addition, the GRS and SHBG showed additive effects on HOMA-IR (P = 0.004).
  
  
  CONCLUSIONS
  The GRS of body fat distribution reflects serum SHBG levels, and the GRS and SHBG jointly influence the risk of insulin resistance.
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU) and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Shi
authors.forename: Lijuan
authors.initials: L
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Hong
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
authors.forename: Bin
authors.initials: B
authors.lastname: Cui
authors.forename: Weiqiong
authors.initials: W
authors.lastname: Gu
authors.forename: Yifei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Miao
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Weiqing
authors.initials: W
authors.lastname: Wang
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
mesh_terms: D050154:Adiposity / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D044466:Asian People; D050218:Body Fat Distribution; D015992:Body Mass Index; D002681:China; D005260:Female; D014644:Genetic Variation; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008245:Lysophospholipase / Q000235:genetics; D012738:Sex Hormone-Binding Globulin / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: C410305:HOXC13 protein, human; D018398:Homeodomain Proteins; D012738:Sex Hormone-Binding Globulin; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D008245:Lysophospholipase; C561408:LYPLAL1 protein, human
keywords: body fat distribution; genetic risk score (GRS); genetic susceptibility; insulin resistance; 关键词：体脂分布，遗传风险评分（GRS），基因易感性，胰岛素抵抗