title: Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats.
abstract: OBJECTIVE
  To analyze the effects of simvastatin (SVT) in the locomotion, anxiety and memory of rats, as a reflection of the administration of a minimum dose capable of stimulating bone regeneration in defects in the calvariae.
  
  
  METHODS
  Surgical procedures were performed in 15 female Wistar rats, 2-month old, to insert the grafting material regenerator (Bone-ceramic®) and/or SVT, followed by behavioural and cognitive assessments in the 7th, 30th and 60th days post surgery.
  
  
  RESULTS
  The SVT locally applied with the goal of bone regeneration in defects created in rat calvariae does not interfere with locomotion, anxiety levels and/or memories of rats, except for the first week following surgery, when an anxiolytic effect was observed, as a result of a possible central action.
  
  
  CONCLUSIONS
  Failure to provoke any response within 30 and 60 days post surgical procedures suggests that SVT may constitute a good choice in stimulating bone regeneration without affecting the long term neural functions.
authors.affiliation: Brasília University, Health Sciences Faculty, BrasíliaDF, Brazil, Fellow Master degree, Postgraduate Program in Health Sciences, Health Sciences Faculty, Brasília University (UNB), Brasília-DF, Brazil. Surgical procedures, acquisition and interpretation of data, manuscript writing.
authors.forename: Dircilei Nascimento de
authors.initials: DN
authors.lastname: Sousa
authors.affiliation: UNB, Health Sciences Faculty, BrasíliaDF, Brazil, Fellow PhD degree, Postgraduate Program in Health Sciences, Health Sciences Faculty, UNB, Brasília-DF, Brazil. Surgical procedures, acquisition and interpretation of data, manuscript writing.
authors.forename: Washington Macedo de
authors.initials: WM
authors.lastname: Santana
authors.affiliation: UNB, Health Sciences Faculty, BrasíliaDF, Brazil, PhD, Full Professor, Health Sciences Faculty, UNB, Brasília-DF, Brazil. Statistical analysis, English language, critical revision.
authors.forename: Vania Moraes
authors.initials: VM
authors.lastname: Ferreira
authors.affiliation: UNB, Health Sciences Faculty, BrasíliaDF, Brazil, PhD, Full Professor, Health Sciences Faculty, UNB, Brasília-DF, Brazil. Conception and design of the study, manuscript writing.
authors.forename: Wagner Rodrigues
authors.initials: WR
authors.lastname: Duarte
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D001007:Anxiety / Q000139:chemically induced; D001522:Behavior, Animal / Q000187:drug effects*; D001861:Bone Regeneration / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D004195:Disease Models, Animal; D005260:Female; D008124:Locomotion / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D017208:Rats, Wistar; D019821:Simvastatin / Q000008:administration & dosage*; D012886:Skull / Q000187:drug effects / Q000601:surgery; D013997:Time Factors
chemical_list: D000924:Anticholesteremic Agents; D019821:Simvastatin