title: Copeptin, a surrogate marker for arginine vasopressin, is associated with cardiovascular risk in patients with polycystic ovary syndrome.
abstract: BACKGROUND
  Women with polycystic ovary syndrome (PCOS) have higher risk for cardiovascular disease (CVD). Copeptin has been found to be predictive for myocardial ischemia. We tested whether copeptin is the predictor for CVD in PCOS patients, who have an increased risk of cardiovascular disease.
  
  
  METHODS
  This was a cross sectional controlled study conducted in a training and research hospital. The study population consisted of 40 reproductive-age PCOS women and 43 control subjects. We evaluated anthropometric and metabolic parameters, carotid intima media thickness and copeptin levels in both PCOS patients and control group.
  
  
  RESULTS
  Mean fasting insulin, homeostasis model assessment insulin resistance index (HOMA-IR), triglyceride, total cholesterol, low density lipoprotein cholesterol (LDL-C), free testosterone, 17-OH progesterone, Dehydroepiandrosterone sulfate (DHEAS), carotid intima media thickness (CIMT) levels were significantly higher in PCOS patients. Mean copeptin level was in 12.61 ± 3.05 pmol/L in PCOS patients while mean copeptin level was 9.60 ± 2.80 pmol/L in healthy control women (p < 0.001). After adjustment for age and BMI, copeptin level was positive correlated with fasting insulin, free testosterone levels, CIMT, and HOM A-IR.
  
  
  CONCLUSIONS
  Copeptin appeared to have an important role in metabolic response and subsequent development of atherosclerosis in insulin resistant, hyperandrogenemic PCOS patients.
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Gaziantep Dr, Ersin Arslan Hospital, Milli Egemenlik bulvarı, Sanlılar Apt, no:51 daire:9 Şehitkamil/Gaziantep, Gaziantep, Turkey. b_karbek@yahoo.com.
authors.forename: Basak
authors.initials: B
authors.lastname: Karbek
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozbek
authors.forename: Melia
authors.initials: M
authors.lastname: Karakose
authors.forename: Oya
authors.initials: O
authors.lastname: Topaloglu
authors.forename: Nujen Colak
authors.initials: NC
authors.lastname: Bozkurt
authors.forename: Evrim
authors.initials: E
authors.lastname: Cakır
authors.forename: Muyesser Sayki
authors.initials: MS
authors.lastname: Aslan
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibasi
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002340:Carotid Artery Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006020:Glycopeptides / Q000097:blood*; D006728:Hormones / Q000097:blood; D006784:Hospitals, Teaching; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000209:etiology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications* / Q000175:diagnosis; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D014421:Turkey; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006020:Glycopeptides; D006728:Hormones; D007328:Insulin; D008055:Lipids; C048197:copeptins