title: [Valacyclovir as an adjunct to full-mouth scaling and root planing of advanced chronic periodontitis:a randomized clinical trail].
abstract: OBJECTIVE
  The aim of this study was to evaluate the clinical benefit of valacyclovir when performing full-mouth periodontal debridement in patients with advanced chronic periodontitis.
  
  
  METHODS
  Fifty-nine patients with advanced chronic periodontitis were randomly assigned into control-treatment group(n=29) and intensive-treatment group(n=30). All patients were given instructions of basic oral hygiene and a standard cycle of supragingival mechanical scaling and polishing. Patients in the intensive-treatment group received oral valacyclovir for 1 week, while patients in the control-treatment group received placebo. Thereafter, patients in both groups underwent full-mouth intensive removal of subgingival dental plaque biofilms with the use of scaling and root planing within 48 hours. Periodontal parameters were evaluated before treatment and 2 or 6 months after treatment. The data was statistically analyzed using SPSS17.0 software package.
  
  
  RESULTS
  No significant difference in clinical parameters was noted before treatment. 2 and 6 months after treatment, the mean percentage reduction of sites with BOP and PD≥4 mm were significantly higher in the intensive-treatment group than in the control-treatment group (P<0.05). Similarly, patients in the intensive-treatment group had higher mean PD reduction than those in the control-treatment group 2 months (P<0.05) and 6 months after therapy (P<0.05). However, the mean values of CAL reduction were slightly and not significantly higher in the intensive-treatment group than in the control-treatment group after therapy.
  
  
  CONCLUSIONS
  It may be concluded that valacyclovir significantly improves clinical results of full-mouth non-surgical periodontal debridement in advanced chronic periodontitis.
authors.affiliation: Department of Stomatology, The First People's Hospital of Lianyungang City. Lianyungang 222002, Jiangsu Province, China.E-mail:fuyongweivip@sina.com.
authors.forename: Yong-wei
authors.initials: YW
authors.lastname: Fu
authors.forename: Xiang-xin
authors.initials: XX
authors.lastname: Li
authors.forename: Yong-qing
authors.initials: YQ
authors.lastname: Gong
authors.forename: Hong-zhi
authors.initials: HZ
authors.lastname: Xu
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives; D018441:Biofilms; D055113:Chronic Periodontitis; D003773:Dental Plaque; D003774:Dental Plaque Index; D012534:Dental Scaling; D005145:Face; D006801:Humans; D010512:Periodontal Index; D010518:Periodontitis; D016745:Root Planing; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives
chemical_list: D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir