title: Expert curation in UniProtKB: a case study on dealing with conflicting and erroneous data.
abstract: UniProtKB/Swiss-Prot provides expert curation with information extracted from literature and curator-evaluated computational analysis. As knowledgebases continue to play an increasingly important role in scientific research, a number of studies have evaluated their accuracy and revealed various errors. While some are curation errors, others are the result of incorrect information published in the scientific literature. By taking the example of sirtuin-5, a complex annotation case, we will describe the curation procedure of UniProtKB/Swiss-Prot and detail how we report conflicting information in the database. We will demonstrate the importance of collaboration between resources to ensure curation consistency and the value of contributions from the user community in helping maintain error-free resources. Database URL: www.uniprot.org.
authors.affiliation: SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland, European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, Protein Information Resource, University of Delaware, 15 Innovation Way, Suite 205, Newark, DE 19711, USA and Protein Information Resource, Georgetown University Medical Center, 3300 Whitehaven Street North West, Suite 1200, Washington, DC 20007, USA.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Poux
authors.forename: Michele
authors.initials: M
authors.lastname: Magrane
authors.forename: Cecilia N
authors.initials: CN
authors.lastname: Arighi
authors.forename: Alan
authors.initials: A
authors.lastname: Bridge
authors.forename: Claire
authors.initials: C
authors.lastname: O'Donovan
authors.forename: Kati
authors.initials: K
authors.lastname: Laiho
mesh_terms: D001331:Automation; D003299:Cooperative Behavior; D057225:Data Mining / Q000379:methods*; D030562:Databases, Protein; D006801:Humans; D058977:Molecular Sequence Annotation; D013223:Statistics as Topic