title: Nomogram for prediction of prostate cancer with serum prostate specific antigen less than 10 ng/mL.
abstract: Although prostate-specific antigen (PSA) is a very useful screening tool, prostate biopsy is still necessary to confirm prostate cancer (PCA). However, it is reported that PSA is associated with a high false-positive rate and prostate biopsy also has various procedure-related complications. Therefore, the authors have devised a nomogram, which can be used to estimate the risk of PCA, using available clinical data for men with a serum PSA less than 10 ng/mL. Prostate biopsies were obtained from 2,139 patients from January 1998 to March 2011. Of them, 1,171 patients with a serum PSA less than 10 ng/mL were only included in this study. Patient age, PSA, free PSA, prostate volume, PSA density and percent free PSA ratio were analyzed. Among 1,171 patients, 255 patients (21.8%) were diagnosed as PCA. Multivariate analyses showed that patient age, prostate volume, PSA and percent free PSA had statistically significant relationships with PCA (P < 0.05) and were used as nomogram predictor variables. The area under the (ROC) curve for all factors in a model predicting PCA was 0.759 (95% CI, 0.716-0.803).
authors.affiliation: Department of Urology and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Ahn
authors.affiliation: Department of Urology and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Jeong Zoo
authors.initials: JZ
authors.lastname: Lee
authors.affiliation: Department of Urology and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Moon Kee
authors.initials: MK
authors.lastname: Chung
authors.affiliation: Department of Urology and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Hong Koo
authors.identifier: 0000-0002-8240-7765
authors.initials: HK
authors.lastname: Ha
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D049451:Nomograms; D011237:Predictive Value of Tests; D011467:Prostate / Q000502:physiology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D017430:Prostate-Specific Antigen
keywords: Biopsy; Nomograms; Prostate; Prostatic Neoplasms