title: Metallic glass thin films for potential biomedical applications.
abstract: We introduce metallic glass thin films (TiCuNi) as biocompatible materials for biomedical applications. TiCuNi metallic glass thin films were deposited on the Si substrate and their structural, surface, and mechanical properties were investigated. The fabricated films showed good biocompatibility upon exposure to muscle cells. Also, they exhibited an average roughness of <0.2 nm, high wear resistance, and high mechanical properties (hardness ∼6.9 GPa and reduced modulus ∼130 GPa). Top surface of the TiCuNi films was shown to be free from Ni and mainly composed of a thin titanium oxide layer, which resulted in the high surface biocompatibility. In particular, there was no cytotoxicity effect of metallic glass films on the C2C12 myoblasts and the cells were able to proliferate well on these substrates. Low cost, viscoelastic behavior, patternability, high electrical conductivity, and the capability to coat various materials (e.g., nonbiocompatible materials) make TiCuNi as an attractive material for biomedical applications.
authors.affiliation: WPI-Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, Sendai, 980-8577, Japan.
authors.forename: Neelam
authors.initials: N
authors.lastname: Kaushik
authors.forename: Parmanand
authors.initials: P
authors.lastname: Sharma
authors.forename: Samad
authors.initials: S
authors.lastname: Ahadian
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
authors.forename: Masaharu
authors.initials: M
authors.lastname: Takahashi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Makino
authors.forename: Shuji
authors.initials: S
authors.lastname: Tanaka
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Esashi
mesh_terms: D000497:Alloys / Q000737:chemistry*; D002460:Cell Line; D005898:Glass / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D032446:Myoblasts / Q000166:cytology / Q000378:metabolism*; D013499:Surface Properties
chemical_list: D000497:Alloys; D008567:Membranes, Artificial
keywords: metallic glass thin films; thin films for biomedical use; tissue engineering