title: Variant-beta luteinizing hormone is not associated with poor ovarian response to controlled ovarian hyperstimulation.
abstract: BACKGROUND
  The most common genetic variant of luteinizing hormone (LH), variant-betaLH, has a different bioactivity than the wildtype. Carrying the variant allele was associated with an increased consumption of exogenous gonadotropin to achieve optimal ovarian response for in vitro fertilization procedures (IVF). The aim of this study was to examine if variant-betaLH was also more common in patients with a poor ovarian response to exogenous gonadotropin which negatively influenced treatment outcome.
  
  
  RESULTS
  36 patients with poor ovarian response to ovarian stimulation for IVF and 98 controls with a normal response were genotyped for variant-betaLH using DNA sequencing. The carrier frequency in the control group was 17%. No association was found between poor ovarian response and variant-betaLH.
  
  
  CONCLUSIONS
  Testing patients for variant-betaLH prior to IVF is unlikely to predict poor ovarian response.
authors.affiliation: Fertilitetsklinikken Sør, Telemark Hospital, Porsgrunn, Norway. Hans.Ivar.Hanevik@sthf.no.
authors.forename: Hans I
authors.initials: HI
authors.lastname: Hanevik
authors.forename: Hilde T
authors.initials: HT
authors.lastname: Hilmarsen
authors.forename: Camilla F
authors.initials: CF
authors.lastname: Skjelbred
authors.forename: Tom
authors.initials: T
authors.lastname: Tanbo
authors.forename: Jarl A
authors.initials: JA
authors.lastname: Kahn
mesh_terms: D000328:Adult; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D037101:Luteinizing Hormone, beta Subunit / Q000097:blood / Q000235:genetics*; D054315:Oocyte Retrieval / Q000379:methods; D010062:Ovulation Induction / Q000379:methods*; D017211:Treatment Failure
chemical_list: D037101:Luteinizing Hormone, beta Subunit