title: Risk-adjusted survival after tissue versus mechanical aortic valve replacement: a 23-year assessment.
abstract: OBJECTIVE
  Detailed analyses of risk-adjusted outcomes after mitral valve surgery have documented significant survival decrements with tissue valves at any age. Several recent studies of prosthetic aortic valve replacement (AVR) also have suggested a poorer performance of tissue valves, although analyses have been limited to small matched series. The study aim was to test the hypothesis that AVR with tissue valves is associated with a lower risk-adjusted survival, as compared to mechanical valves.
  
  
  METHODS
  Between 1986 and 2009, primary isolated AVR, with or without coronary artery bypass grafting (CABG), was performed with currently available valve types in 2148 patients (1108 tissue valves, 1040 mechanical). Patients were selected for tissue valves to be used primarily in the elderly. Baseline and operative characteristics were documented prospectively with a consistent variable set over the entire 23-year period. Follow up was obtained with mailed questionnaires, supplemented by National Death Index searches. The average time to death or follow up was seven years, and follow up for survival was 96.2% complete. Risk-adjusted survival characteristics for the two groups were evaluated using a Cox proportional hazards model with stepwise selection of candidate variables.
  
  
  RESULTS
  Differences in baseline characteristics between groups were (tissue versus mechanical): median age 73 versus 61 years; non-elective surgery 32% versus 28%; CABG 45% versus 35%; median ejection fraction 55% versus 55%; renal failure 6% versus 1%; diabetes 18% versus 7% (p<0.01). Unadjusted Kaplan-Meier survival was significantly lower with tissue than mechanical valves; however, after risk adjustment for the adverse profiles of tissue valve patients, no significant difference was observed in survival after tissue or mechanical AVR. Thus, the hypothesis did not hold, and risk-adjusted survival was equivalent, of course qualified by the fact that selection bias was evident.
  
  
  CONCLUSIONS
  With selection criteria that employed tissue AVR more frequently in elderly patients, tissue and mechanical valves achieved similar survival characteristics across the spectrum of patient risk. Further studies of the relative outcomes of mechanical versus tissue valves across the spectrum of patient age seem indicated.
authors.affiliation: Duke University Medical Center, Durham, NC 27710, USA. jeffrey.gaca@duke.edu
authors.forename: Jeffrey G
authors.initials: JG
authors.lastname: Gaca
authors.affiliation: Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Clare
authors.affiliation: Vanderbilt University, Nashville, TN, USA.
authors.forename: J Scott
authors.initials: JS
authors.lastname: Rankin
authors.affiliation: Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Mani A
authors.initials: MA
authors.lastname: Daneshmand
authors.affiliation: Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Carmelo A
authors.initials: CA
authors.lastname: Milano
authors.affiliation: Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: G Chad
authors.initials: GC
authors.lastname: Hughes
authors.affiliation: Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Walter G
authors.initials: WG
authors.lastname: Wolfe
authors.affiliation: Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Donald D
authors.initials: DD
authors.lastname: Glower
authors.affiliation: Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Smith
mesh_terms: D000367:Age Factors; D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D001705:Bioprosthesis; D005260:Female; D006349:Heart Valve Diseases / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D016016:Proportional Hazards Models; D011474:Prosthesis Design; D012189:Retrospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome