title: [Efficiency of hydroxyethyl starch use for arterial hypotension and shock in early postoperative period].
abstract: It is common knowledge that arterial hypotension is a one of most prevalent pathology of early neonatal period and it causes severe neurological complications. Purpose of the prospective randomized open study was to assess the efficacy of HES 130/0.4 (6% Voluven) as a start medicine for arterial hypotension in early neonatal period in comparison with normal saline solution (0.9% NaCl).
  
  
  METHODS
  the study was held from January 2010 to September 2011. Newborns of the ICU with arterial hypotension on the first day of life were included into the study. Acute haemorrhage was an exclusion criterion. Routine monitoring of arterial pressure, heart rate and diuresis was carried out in all newborns. pH, pCO2, pO2 blood glucose, lactate and BE levels were measured before and after the treatment. Echocardiography, examination of regional blood flow in anterior cerebral artery, renal artery and mesenteric artery was held HES 130/0.4 (6% Voluven) and saline solution (0.9% NaCl) were used Parameters of haemostasis, biochemical and haematological analysis monitored after the solutions use. Time of arterial pressure normalization and duration of the treatment positive effect were recorded Episodes of hypotension, amount of cardiotonics per day and per 7 days and duration of cardiotonics administration were recorded as well.
  
  
  RESULTS
  6% Voluven infusion both to 0.9% NaCl infusion normalizes the regional circulation. Furthermore it increases the blood pH and diuresis. Lactate level normalization occurred only after 6% Voluven infusion. There was not change of serum sodium level. Liver enzymes, C-protein, prothrombin index were same in both groups of patients. 6% Voluven use in newborns with extremely low birth weight was accompanied with increasing of creatinine level, prolongation of activated partial thromboplastin time and increasing of intraventricular hemorrhage rate. Newborns with weight over 1000 gram did not have these complications. Voluven advantage in comparison with saline solution is a decreasing of cardiotonics administration in patients with weight over 1000 gram.
  
  
  CONCLUSIONS
  6% Voluven is more effective than 0.9% NaCl for increasing of cardiac output, myocardial contractile ability and diuresis, normalization of liquid balance and lactate level, decreasing of cardiotonics amount. 6% Voluven can be recommended for arterial hypotension treatment in newborns with weight over 1000 gram both to normal saline solution especially in case of shock.
authors.forename: D S
authors.initials: DS
authors.lastname: Kriuchko
authors.forename: O V
authors.initials: OV
authors.lastname: Ionov
authors.forename: E N
authors.initials: EN
authors.lastname: Balashova
authors.forename: A R
authors.initials: AR
authors.lastname: Kirtbaia
authors.forename: I V
authors.initials: IV
authors.lastname: Nikitina
authors.forename: L A
authors.initials: LA
authors.lastname: Krasnova
authors.forename: L V
authors.initials: LV
authors.lastname: Sharipova
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Terliakova
authors.forename: O V
authors.initials: OV
authors.lastname: Milaia
mesh_terms: D001810:Blood Volume / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000494:pharmacology*; D007022:Hypotension / Q000628:therapy*; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007552:Isotonic Solutions; D008297:Male; D010952:Plasma Substitutes / Q000008:administration & dosage / Q000494:pharmacology*; D011446:Prospective Studies; D000077325:Ringer's Lactate; D012769:Shock / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: C485123:HES 130-0.4; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D000077325:Ringer's Lactate