title: The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence.
abstract: Protein phosphatases Z that are unique to the fungal kingdom have been associated to resistance to high salt concentration, cell wall integrity, cell cycle regulation, and oxidative stress in fungi. In Aspergillus fumigatus, it was shown that PHZA is under the control of the transcription factor Skn7 and is only involved in the control of the oxidative stress. Accordingly, the ΔphzA mutant showed a defect in virulence in an experimental model of corneal infection in immunocompetent animals and that the impact on susceptibility to cell wall drugs is only secondary.
authors.affiliation: Unité des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. Electronic address: llaetitia.muszkieta@pasteur.fr.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Muszkieta
authors.affiliation: Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Steven de Jesus
authors.initials: Sde J
authors.lastname: Carrion
authors.affiliation: Université Pierre et Marie Curie-Paris 6, INSERM UMR-S 945, Immunité et Infection, Hôpital Pitié Salpêtrière, Paris, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Robinet
authors.affiliation: Unité des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.
authors.forename: Rémi
authors.initials: R
authors.lastname: Beau
authors.affiliation: Université Pierre et Marie Curie-Paris 6, INSERM UMR-S 945, Immunité et Infection, Hôpital Pitié Salpêtrière, Paris, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Elbim
authors.affiliation: Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Pearlman
authors.affiliation: Unité des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Latgé
mesh_terms: D000818:Animals; D001228:Aspergillosis / Q000378:metabolism / Q000517:prevention & control*; D001232:Aspergillus fumigatus / Q000378:metabolism* / Q000472:pathogenicity; D002473:Cell Wall / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism*; D055786:Gene Knockout Techniques; D006801:Humans; D007634:Keratitis / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009154:Mutation; D009504:Neutrophils / Q000378:metabolism; D018384:Oxidative Stress; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014774:Virulence
chemical_list: D005656:Fungal Proteins; D017382:Reactive Oxygen Species; D010749:Phosphoprotein Phosphatases
keywords: Aspergillus fumigatus; Corneal infection; Oxidative stress; Phosphatase; Virulence