title: Predisposing factors associated with uncomplicated type 2 diabetes among adults in a diabetic clinic, Enugu State, Nigeria.
abstract: BACKGROUND
  The role of micronutrients and other predisposing factors associated with the aetiology of type 2 diabetes in Nigeria is not well established. The objectives of this study were to investigate predisposing factors associated with uncomplicated type 2 diabetes among a Nigerian adult population.
  
  
  METHODS
  Predisposing factors associated with uncomplicated type 2 diabetes were investigated in 60 Igbo (a major tribe in Eastern Nigeria) adults aged 30-90 years. This study was carried out at the Diabetic Clinic, University of Nigeria Teaching Hospital (UNTH) Ituku-Ozalla, Enugu. Packed cell volume (PCV), serum ferrtin and some anthropometric parameters were measured alongside fasting blood sugar (FBS).
  
  
  RESULTS
  PCV recorded a statistically significant lower (p<0.001) mean value at 32.94±0.61% in the patients when compared with the control group with a mean value of 39.06±1.02%. Serum ferritin revealed a statistically significant higher (p<0.01; 110.20±15.17 ng/ml) mean value in the patients when compared with the control group (20.4±5.64 ng/ml). However, PCV (32.00±0.88%) and body mass index (BMI) (31.99±1.12 Kg/m(2)) recorded a statistically significant lower (p<0.05) mean value in female patients when compared with their corresponding males. There was no significant correlation (p>0.05) between serum iron ferritin, FBS and all other anthropometric predictors of incidence of type 2 diabetes.
  
  
  CONCLUSIONS
  Type 2 diabetes is not associated with elevated levels of serum iron ferritin. Hence, serum ferritin may not be a better predictor of type 2 diabetes, especially in uncomplicated cases.
authors.affiliation: Department of Medical Laboratory Sciences.
authors.forename: Thomas
authors.initials: T
authors.lastname: Nubila
authors.forename: Ernest O
authors.initials: EO
authors.lastname: Ukaejiofo
authors.forename: Samuel O
authors.initials: SO
authors.lastname: Ike
authors.forename: Elvis N
authors.initials: EN
authors.lastname: Shu
authors.forename: Nkoyo I
authors.initials: NI
authors.lastname: Nubila
authors.forename: Chioli P
authors.initials: CP
authors.lastname: Chijioke
authors.forename: Ayodele C
authors.initials: AC
authors.lastname: Ukaejiofo
authors.forename: Eghosa E
authors.initials: EE
authors.lastname: Iyare
authors.forename: Chukwubuzor U
authors.initials: CU
authors.lastname: Okwosa
authors.forename: Onyinye V
authors.initials: OV
authors.lastname: Okwuowulu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D005293:Ferritins / Q000097:blood; D006400:Hematocrit; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D005293:Ferritins
keywords: Nigeria; Risk factors; Serum ferritin; Type 2 diabetes