title: Primary cutaneous cryptococcosis in an immunocompetent patient due to Cryptococcus gattii molecular type VGI in Brazil: a case report and review of literature.
abstract: Primary Cutaneous Cryptococcosis is an uncommon infection caused by the yeast Cryptococcus neoformans and C. gattii. Few case reports are available in the literature describing in detail primary cutaneous cryptococcosis due to C. gattii in immunocompetent patients. Herein, we present a case of a 68-year-old immunocompetent male patient with erythematous nodular lesions on the right forearm due to C. gattii mating-type α and molecular type VGI. The virulence factors test was performed for capsule diameter, melanin production and phospholipase activity. In vitro fluconazole testing showed the sensitivity profile of this clinical isolate. In addition, a review of the literature on this subject was carried out and verified that this is the first reported case of VGI in the south-east region of Brazil.
authors.affiliation: Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil.
authors.forename: Erika
authors.initials: E
authors.lastname: Nascimento
authors.forename: Maria Emília Nadaletto
authors.initials: ME
authors.lastname: Bonifácio da Silva
authors.forename: Roberto
authors.initials: R
authors.lastname: Martinez
authors.forename: Marcia Regina
authors.initials: MR
authors.lastname: von Zeska Kress
mesh_terms: D000368:Aged; D001938:Brazil; D003453:Cryptococcosis / Q000276:immunology / Q000382:microbiology*; D056285:Cryptococcus gattii / Q000145:classification / Q000302:isolation & purification*; D006801:Humans; D007121:Immunocompetence; D008297:Male
keywords: Cryptococcus gattii; antifungal therapy; immunocompetent patient; molecular type VGI; primary cutaneous cryptococcosis - PCC; virulence factors