title: ETV6-RUNX1-positive ALL may be driven by aberrant RAG activity.
abstract: Secondary mutational events in ETV6-RUNX1 -positive ALL bear hallmarks of off-target RAG activity.
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics* / Q000378:metabolism; D004720:Endonucleases / Q000502:physiology*; D042822:Genomic Instability; D006801:Humans; D015514:Oncogene Proteins, Fusion / Q000235:genetics* / Q000378:metabolism; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D012097:Repressor Proteins; D014157:Transcription Factors / Q000235:genetics; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D050676:Core Binding Factor Alpha 2 Subunit; D004720:Endonucleases; D015514:Oncogene Proteins, Fusion; D012097:Repressor Proteins; D014157:Transcription Factors; C501309:ATF7IP protein, human; C584050:MGA protein, human; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein