title: A new periplogenin cardenolide from the seeds of Antiaris toxicaria.
abstract: A new periplogenin cardenolide, periplogulcoside (1), together with three known cardenolides, was isolated from the seeds of Antiaris toxicaria. The structure of the new compound was characterized as periplogenin-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (1) by spectroscopic methods including 1D and 2D NMR, HR-TOF-MS, and CD spectrometry, and the known compounds were identified by comparison of their NMR and HR-TOF-MS data with those reported in the literature. Compound 1 showed significant cytotoxicity against Hela and HepG-2 cell lines.
authors.affiliation: a College of Pharmacy, Ningxia Medical University , Yinchuan 750004 , China.
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Wu
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Wu
authors.forename: Hou-Gang
authors.initials: HG
authors.lastname: Li
authors.forename: He-Tao
authors.initials: HT
authors.lastname: Liu
authors.forename: Xue-Yan
authors.initials: XY
authors.lastname: Fu
authors.forename: Rui-Qin
authors.initials: RQ
authors.lastname: Cui
authors.forename: Jian-Huan
authors.initials: JH
authors.lastname: Wang
authors.forename: Cheng
authors.initials: C
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
mesh_terms: D031621:Antiaris / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C000588522:periplogulcoside