title: A malonitrile-functionalized metal-organic framework for hydrogen sulfide detection and selective amino acid molecular recognition.
abstract: A novel porous polymeric fluorescence probe, MN-ZIF-90, has been designed and synthesized for quantitative hydrogen sulfide (H2S) fluorescent detection and highly selective amino acid recognition. This distinct crystalline structure, derived from rational design and malonitrile functionalization, can trigger significant enhancement of its fluorescent intensity when exposed to H2S or cysteine molecules. Indeed this new metal-organic framework (MOF) structure shows high selectivity of biothiols over other amino acids and exhibits favorable stability. Moreover, in vitro viability assays on HeLa cells show low cytotoxicity of MN-ZIF-90 and its imaging contrast efficiency is further demonstrated by fluorescence microscopy studies. This facile yet powerful strategy also offers great potential of using open-framework materials (i.e. MOFs) as the novel platform for sensing and other biological applications.
authors.affiliation: Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P.R. China.
authors.forename: Haiwei
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P.R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Feng
authors.affiliation: Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P.R. China.
authors.forename: Yuexin
authors.initials: Y
authors.lastname: Guo
authors.affiliation: College of Materials Science & Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P.R. China.
authors.forename: Didi
authors.initials: D
authors.lastname: Chen
authors.affiliation: Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P.R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P.R. China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Ren
authors.affiliation: Spine Surgery, Chinese-Japanese Friendship Hospital, East Yinghua Street, Beijing, 100029, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jiang
authors.affiliation: College of Materials Science & Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P.R. China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P.R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
mesh_terms: D000596:Amino Acids / Q000032:analysis* / Q000737:chemistry; D001672:Biocompatible Materials; D015374:Biosensing Techniques; D045744:Cell Line, Tumor; D003545:Cysteine / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006862:Hydrogen Sulfide / Q000032:analysis* / Q000737:chemistry; D008856:Microscopy, Fluorescence; D013438:Sulfhydryl Compounds / Q000032:analysis
chemical_list: D000596:Amino Acids; D001672:Biocompatible Materials; D005456:Fluorescent Dyes; D013438:Sulfhydryl Compounds; D003545:Cysteine; D006862:Hydrogen Sulfide