title: Long-lasting HHV-6 reactivation in long-term adult survivors after double umbilical cord blood allogeneic stem cell transplantation.
abstract: Higher incidence of human herpesvirus 6 (HHV-6) infection has been documented after umbilical cord blood allo-transplant in adults. Here we demonstrate that HHV-6 reactivation persists for a very long time in half of the patients after this type of graft. Long-term immune reconstitution does not explain this event, which remains to be explained.
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Département de Virologie, Nantes France and EA4271 «Immunovirology and Genetic Polymorphism», University of Nantes.
authors.forename: Marina
authors.initials: M
authors.lastname: Illiaquer
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Nantes.
authors.forename: Florent
authors.initials: F
authors.lastname: Malard
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Nantes.
authors.forename: Thierry
authors.initials: T
authors.lastname: Guillaume
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Département de Virologie, Nantes France and EA4271 «Immunovirology and Genetic Polymorphism», University of Nantes.
authors.forename: Berthe-Marie
authors.initials: BM
authors.lastname: Imbert-Marcille
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Nantes.
authors.forename: Jacques
authors.initials: J
authors.lastname: Delaunay
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Nantes.
authors.forename: Amandine
authors.initials: A
authors.lastname: Le Bourgeois
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Département d'Immunologie, Nantes.
authors.forename: Marie
authors.initials: M
authors.lastname: Rimbert
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Département de Virologie, Nantes France and EA4271 «Immunovirology and Genetic Polymorphism», University of Nantes.
authors.forename: Celine
authors.initials: C
authors.lastname: Bressollette-Bodin
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Nantes.
authors.forename: Cristina
authors.initials: C
authors.lastname: Precupanu
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Nantes.
authors.forename: Sameh
authors.initials: S
authors.lastname: Ayari
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Nantes.
authors.forename: Pierre
authors.initials: P
authors.lastname: Peterlin
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Nantes.
authors.forename: Philippe
authors.initials: P
authors.lastname: Moreau
authors.affiliation: Hôpital Saint Antoine, Hématologie Clinique, Paris, France.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Mohty
authors.affiliation: Centre Hospitalier et Universitaire (CHU) de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Nantes.
authors.forename: Patrice
authors.initials: P
authors.lastname: Chevallier
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005312:Fetal Blood / Q000637:transplantation; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006566:Herpesviridae Infections / Q000276:immunology*; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014775:Virus Activation / Q000276:immunology*; D055815:Young Adult
keywords: HHV-6; PBSC; adults; allo-SCT; cord blood; immune reconstitution