title: Dual functional AuNRs@MnMEIOs nanoclusters for magnetic resonance imaging and photothermal therapy.
abstract: A novel dual functional theranosis platform is developed based on manganese magnetism-engineered iron oxide (MnMEIO) and gold nanorods (AuNRs) to combine magnetic resonance (MR) imaging and photothermal therapy in one nanocluster. The platform showed improved T2-weighted MR imaging and exhibited a near-infrared (NIR) induced temperature elevation due to the unique characteristics of AuNRs@MnMEIOs nanoclusters. The obtained dual functional spherical-shaped nanoclusters showed low cytotoxicity, and high cellular uptake efficiency. The AuNRs@MnMEIOs nanoclusters also demonstrated a 1.9 and 2.2 folds r2 relaxivity value higher than those of monodispersed MnMEIO and Resovist. In addition, in vivo MR imaging study found that the contrast enhancements were - 70.4 ± 4.3% versus - 7.5 ± 3.0% in Her-2/neu overexpression tumors as compared to the control tumors. More importantly, NIR laser irradiation to the tumor site resulted in outstanding photothermal therapeutic efficacy and without damage to the surrounding tissue. In additional, the prepared dual functional AuNRs@MnMEIOs display high stability and furthermore disperse even in the presence of external magnet, showing that AuNRs@MnMEIOs nanoclusters can be manipulated by an external magnetic field. Therefore, such nanoclusters combined MR imaging and photothermal therapeutic functionality can be developed as a promising nanosystem for effective cancer diagnosis and therapy.
authors.affiliation: Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, 75 Bo-Ai Street, Hsinchu 30068, Taiwan.
authors.forename: Yao-Chen
authors.initials: YC
authors.lastname: Chuang
authors.affiliation: Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, 75 Bo-Ai Street, Hsinchu 30068, Taiwan.
authors.forename: Chia-Jung
authors.initials: CJ
authors.lastname: Lin
authors.affiliation: Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, 75 Bo-Ai Street, Hsinchu 30068, Taiwan.
authors.forename: Shih-Feng
authors.initials: SF
authors.lastname: Lo
authors.affiliation: Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, 75 Bo-Ai Street, Hsinchu 30068, Taiwan.
authors.forename: Jei-Lin
authors.initials: JL
authors.lastname: Wang
authors.affiliation: Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, 75 Bo-Ai Street, Hsinchu 30068, Taiwan.
authors.forename: Shey-Cherng
authors.initials: SC
authors.lastname: Tzou
authors.affiliation: Translational Research Center, Cancer Center, and Department of Obstetrics and Gynecology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
authors.forename: Shyng-Shiou
authors.initials: SS
authors.lastname: Yuan
authors.affiliation: Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, 75 Bo-Ai Street, Hsinchu 30068, Taiwan; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Electronic address: ymwang@mail.nctu.edu.tw.
authors.forename: Yun-Ming
authors.initials: YM
authors.lastname: Wang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005290:Ferric Compounds / Q000737:chemistry / Q000627:therapeutic use*; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008345:Manganese / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D043942:Nanotubes / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000628:therapy*; D010789:Phototherapy / Q000379:methods
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D008345:Manganese; D006046:Gold
keywords: Gold nanorods; MR imaging; Manganese-doped iron oxide; Photothermal; Theranosis