title: Class II HDACs and neuronal regeneration.
abstract: The vastly more superior regenerative capacity of the axons of peripheral nerves over central nervous system (CNS) neurons has been partly attributed to the former's intrinsic capacity to initiate and sustain the functionality of a new growth cone. Growth cone generation involves a myriad of processes that centers around the organization of microtubule bundles. Histone deacetylases (HDACs) modulate a wide range of key neuronal processes such as neural progenitor differentiation, learning and memory, neuronal death, and degeneration. HDAC inhibitors have been shown to be beneficial in attenuating neuronal death and promoting neurite outgrowth and axonal regeneration. Recent advances have provided insights on how manipulating HDAC activities, particularly the type II HDACs 5 and 6, which deacetylate tubulin, may benefit axonal regeneration. These advances are discussed herein.
authors.affiliation: Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Medical Drive, Singapore, 117597, Singapore.
authors.forename: Bor Luen
authors.initials: BL
authors.lastname: Tang
mesh_terms: D000107:Acetylation; D001369:Axons / Q000502:physiology*; D002454:Cell Differentiation; D002490:Central Nervous System / Q000502:physiology; D020439:Growth Cones; D056464:Histone Deacetylase 2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D000073864:Histone Deacetylase 6; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D009416:Nerve Regeneration / Q000502:physiology*; D014404:Tubulin / Q000378:metabolism*
chemical_list: D056572:Histone Deacetylase Inhibitors; D014404:Tubulin; C404500:HDAC5 protein, human; C433811:HDAC6 protein, human; D056464:Histone Deacetylase 2; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases
keywords: AXONAL REGENERATION; HDAC5; HDAC6; HISTONE DEACETYLASES (HDACs); NEURITE OUTGROWTH