title: [Insulin infusion in intensive care: randomized controlled trial].
abstract: This randomized controlled trial compared the use of an intensive and conventional insulin protocol on clinical outcomes in patients with severe sepsis and septic shock, in the first 72 hours. It was conducted at a university hospital in the city of São Paulo. Patients (n=46) were allocated into two groups: intensive glycemic (blood glucose between 80-110mg/dl) and conventional (180-220mg/dl). The Student's t-test and chi-square test were used for data analysis. A statistically significant (p<0.001) difference was observed in mean glycemia, but there was no difference in the variables of mean minimum arterial pressure (p=0.06) or maximum (p=0.11), serum creatinine (p=0,33) or in mortality (p=0.11). Although there was no difference between the groups regarding mortality, hemodynamic instability in the conventional group was longer and the only deaths occurred in it.
authors.affiliation: Enfermeira. Especialista em Enfermagem em Terapia Intensiva. Mestre pelo Programa de Pós-Gradua,o em Enfermagem na Saúde do Adulto da Escola de Enfermagem da Universidade de São Paulo. São Paulo, SP, Brasil. enfi_mi@yahoo.com.br
authors.forename: Milena Penteado Ferraro
authors.initials: MP
authors.lastname: Miranda
authors.affiliation: Enfermeiro. Especialista em Enfermagem em Cardiologia. Enfermeiro do Instituto do Coragao do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo. São Paulo, SP, Brasil.
authors.forename: Jeiel Carlos Lamonica
authors.initials: JC
authors.lastname: Crespo
authors.affiliation: Enfermeira. Professora Associada do Departamento de Enfermagem Medico-Cinrurgica da Escola de Enfermagem da Universidade de São Paulo. São Paulo, SP, Brasil.
authors.forename: Silvia Regina
authors.initials: SR
authors.lastname: Secoli
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D003422:Critical Care; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000097:blood / Q000188:drug therapy*; D012772:Shock, Septic / Q000097:blood / Q000188:drug therapy*
chemical_list: D001786:Blood Glucose; D007328:Insulin