title: Validation of the questionnaire for impulsive-compulsive disorders in Parkinson's disease (QUIP) and the QUIP-rating scale in a German speaking sample.
abstract: Impulsive-compulsive disorders are frequent in patients with Parkinson's disease (PD). Recently, a screening questionnaire and rating scale were developed for these disorders: the questionnaire for impulsive-compulsive disorders (QUIP) and QUIP-rating scale (QUIP-RS). We assessed the validity of these instruments in the German language in order to reevaluate the benefit and to obtain German screening tools in clinical practice. A convenience sample of 156 patients was assessed in Kiel and Vienna. The patients filled out the QUIP-current, the QUIP-anytime and the QUIP-RS. We validated the questionnaires against a gold standard diagnosis via receiver operating characteristic curves and determined optimal cut-off scores for the instruments. Excluding walkabout, which was not shown to be valid, sensitivities ranged from 60-92 % for the QUIP-current, 68-91 % for the QUIP-anytime, and 73-100 % for the QUIP-RS. Specificities were >71 % for QUIP-current, >69 % for QUIP-anytime and >62 % for QUIP-RS. With its very good sensitivities, the QUIP-RS is a valid instrument to assess impulsive-compulsive disorders and makes an early detection of behavioral disorders in PD possible. The QUIP-anytime was also shown to be a valid screening instrument. Both are expected to prove useful in scientific and clinical practice.
authors.affiliation: Department of Neurology, Kiel University, Kiel, Germany, c.probst@neurologie.uni-kiel.de.
authors.forename: Catharina Claudia
authors.initials: CC
authors.lastname: Probst
authors.forename: Lina Marie
authors.initials: LM
authors.lastname: Winter
authors.forename: Bettina
authors.initials: B
authors.lastname: Möller
authors.forename: Heinz
authors.initials: H
authors.lastname: Weber
authors.forename: Daniel
authors.initials: D
authors.lastname: Weintraub
authors.forename: Karsten
authors.initials: K
authors.lastname: Witt
authors.forename: Günther
authors.initials: G
authors.lastname: Deuschl
authors.forename: Regina
authors.initials: R
authors.lastname: Katzenschlager
authors.forename: Thilo
authors.initials: T
authors.lastname: van Eimeren
mesh_terms: D000368:Aged; D003192:Compulsive Behavior / Q000175:diagnosis* / Q000523:psychology; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019303:Multilingualism; D010300:Parkinson Disease / Q000175:diagnosis* / Q000523:psychology; D011569:Psychiatric Status Rating Scales / Q000592:standards*; D011795:Surveys and Questionnaires