title: α-Glucosidase inhibitory activity of protein-rich extracts from extruded adzuki bean in diabetic KK-Ay mice.
abstract: An extrusion process has been widely used for the development of many functional foods. The aim of this study was to assess the effect of the extrusion process on the α-glucosidase inhibitory properties of adzuki bean protein in type 2 diabetes model KK-A(y) mice. The extruded adzuki bean protein (EA) was prepared by adding 1% and 2% into the diet for 42 days. It was found that the fasting blood glucose concentration was significantly decreased with the EA-2 group compared with the control diabetic mice group. In addition, there was a significant decrease in serum triglyceride, blood urea nitrogen levels and increased high density lipoprotein (HDL)-cholesterol. Meanwhile, hepatic lipids were improved and the content of α-dicarbonyl compounds in the kidney were reduced in mice fed with EA. These results suggest that the intake of EA could moderate type 2 diabetes and diabetic complications.
authors.affiliation: Institute of Crop Science, Chinese Academy of Agricultural Sciences, South Xueyuan Road, Haidian District No.80, 100081 Beijing, People's Republic of China. renguixing@caas.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yao
authors.forename: Xuzhen
authors.initials: X
authors.lastname: Cheng
authors.forename: Guixing
authors.initials: G
authors.lastname: Ren
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000201:enzymology* / Q000235:genetics; D007887:Fabaceae / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000008:administration & dosage*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage*; D014280:Triglycerides / Q000097:blood; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D014280:Triglycerides; D000520:alpha-Glucosidases