title: Associations between SNPs within antioxidant genes and the risk of prostate cancer in the Siberian region of Russia.
abstract: In the present study we investigated the association of a number of polymorphic changes in antioxidant system genes (SNPs rs1050450 in the GPX1 gene, rs1695 and rs1138272 in the GSTP1 gene and rs4880 in the MnSOD gene) with the risk of prostate cancer. The association of disease stage and PSA levels with specific genotypes was also analyzed. A study was conducted with the participation of 736 Russian men. We compared the frequency of occurrence of the studied alleles in patients with prostate cancer (392) to a control group (344) of men without a history of cancer. Genotyping was performed by real-time PCR. Comparison of frequencies of alleles and genotypes were performed using logistic regression analysis. No statistically significant association with the risk of prostate cancer was found for any of the SNPs studied (p > 0.05). For SNP rs1695 in the GSTP1 gene, a correlation with cancer disease stage was observed: a GG genotype is significantly more common in patients with PCa in the 3rd and 4th stage than 1st and 2nd (OR[95%CI] = 2.66[1.15-6.18], p = 0.02). Both studied SNPs of GSTP1 gene are associated with the level of PSA: the GG rs1695 and the TT rs1138272 genotypes are associated with higher PSA levels (p = 1.5*10(-3)).
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia, nattasha.o@gmail.com.
authors.forename: N A
authors.initials: NA
authors.lastname: Oskina
authors.forename: N A
authors.initials: NA
authors.lastname: Еrmolenko
authors.forename: U A
authors.initials: UA
authors.lastname: Boyarskih
authors.forename: A  F
authors.initials: A
authors.lastname: Lazarev
authors.forename: V D
authors.initials: VD
authors.lastname: Petrova
authors.forename: D I
authors.initials: DI
authors.lastname: Ganov
authors.forename: O G
authors.initials: OG
authors.lastname: Tonacheva
authors.forename: G I
authors.initials: GI
authors.lastname: Lifschitz
authors.forename: M L
authors.initials: ML
authors.lastname: Filipenko
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005979:Glutathione Peroxidase / Q000235:genetics*; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors; D012426:Russia; D013482:Superoxide Dismutase / Q000235:genetics*; D015996:Survival Rate; D000094765:Glutathione Peroxidase GPX1
chemical_list: D000975:Antioxidants; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human