title: Feline atopic dermatitis: a retrospective study of 45 cases (2001-2012).
abstract: BACKGROUND
  Atopic dermatitis (AD) is recognized as a common cause of pruritus in cats, but it remains incompletely characterized.
  
  
  OBJECTIVE
  The aim of the study was to evaluate cases of confirmed feline AD.
  
  
  METHODS
  Fourty-five cats from a dermatology referral practice (2001-2012).
  
  
  METHODS
  A retrospective case record review was carried out using strict diagnostic criteria, including exclusion of flea-bite hypersensitivity and adverse food reaction.
  
  
  RESULTS
  Disease prevalence was 12.5%, with domestic mixed (n = 24), Abyssinian (n = 6) and Devon rex (n = 3) cat breeds predisposed. Median age of onset was 2 years (62% <3 years; 22% >7 years; range 3 months to 12 years). Common presentations were severe (82%), nonseasonal (82%), waxing/waning (36%) pruritus, with alopecia/crusting/excoriations and/or erosions/ulceration (73%). Miliary dermatitis (20%) and eosinophilic granuloma complex lesions (27%) occurred. The face/head (71%), ventral abdomen (51%), neck (51%), limbs (38%), pinnae (31%), dorsum/rump (31%) and feet (16%) were frequently affected sites; lesions were restricted to the head/neck in only five cats (11%). Concurrent otitis externa (16%), superficial bacterial pyoderma (49%), Malassezia dermatitis (7%), flea-bite hypersensitivity (24%) and adverse food reaction (13%) occurred. Strong reactions on intradermal allergen testing were common (68%; 19 of 30), most frequently to pollens (61%) and/or insects (46%). Good response to ciclosporin (100%; 10 of 10), systemic glucocorticoids (55%; 22 of 40) and allergen-specific immunotherapy (57%; 13 of 23) and good/partial response to antihistamines (67%; 22 of 33) were reported.
  
  
  CONCLUSIONS
  The prevalence of feline AD was higher than previously suggested, and breed predispositions were confirmed. Severe nonseasonal pruritus was most common, with a varied spectrum of lesions affecting a range of body areas.
authors.affiliation: Small Animal Specialist Hospital, Level 1, 1 Richardson Place, North Ryde, NSW, 2113, Australia.
authors.forename: Philippa A
authors.initials: PA
authors.lastname: Ravens
authors.forename: Bei J
authors.initials: BJ
authors.lastname: Xu
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Vogelnest
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D002371:Cat Diseases / Q000097:blood / Q000276:immunology / Q000473:pathology*; D002415:Cats; D003876:Dermatitis, Atopic / Q000097:blood / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D007428:Intradermal Tests / Q000662:veterinary; D008297:Male; D011537:Pruritus / Q000473:pathology / Q000662:veterinary; D012189:Retrospective Studies; D012621:Seasons
chemical_list: D000485:Allergens; D007073:Immunoglobulin E