title: [Effect of GABA derivative--RSMU-151 on the development of oxidative stress in rats with experimental gestosis].
abstract: Experimental gestosis induced in rats by drinking 1.8% sodium chloride solution instead of water during the entire period of pregnancy leads to activation of lipid peroxidation (LPO) process, as manifested by increased concentration of diene conjugates and malonic dialdehyde, decreased concentration of antioxidant enzymes (superoxide dismutase and glutathione peroxidase) in homogenates of rat brain, liver, uterus, and placenta. The GABA derivatives--RSMU-151 limits the damaging effect of gestosis, which is manifested by a decrease in the concentration of LPO products and by activation of the antioxidant system enzymes in all organs studied.
authors.forename: I N
authors.initials: IN
authors.lastname: Tiurenkov
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: T A
authors.initials: TA
authors.lastname: Popova
authors.forename: V I
authors.initials: VI
authors.lastname: Karamysheva
authors.forename: L B
authors.initials: LB
authors.lastname: Reznikova
authors.forename: I I
authors.initials: II
authors.lastname: Prokof'ev
authors.forename: I S
authors.initials: IS
authors.lastname: Mokrousov
authors.forename: E I
authors.initials: EI
authors.lastname: Gridin
authors.forename: L I
authors.initials: LI
authors.lastname: Mikhaĭlova
authors.forename: V M
authors.initials: VM
authors.lastname: Berestovitskaia
authors.forename: O S
authors.initials: OS
authors.lastname: Vasil'eva
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D018682:GABA Agents / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D010920:Placenta / Q000378:metabolism / Q000473:pathology; D011225:Pre-Eclampsia / Q000097:blood* / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D013482:Superoxide Dismutase / Q000097:blood; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D018682:GABA Agents; D005680:gamma-Aminobutyric Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase