title: Aminofluorination of 2-alkynylanilines: a Au-catalyzed entry to fluorinated indoles.
abstract: The scope and limitations of gold-catalyzed tandem cycloisomerization/fluorination reactions of unprotected 2-alkynylanilines to have access to 3,3-difluoro-2-aryl-3H-indoles and 3-fluoro-2-arylindoles are described. An unprecedented aminoauration/oxidation/fluorination cascade reaction of 2-alkynylanilines bearing a linear alkyl group on the terminal triple bond is reported.
authors.affiliation: Dipartimento di Scienze Fisiche e Chimiche, Università di L'Aquila, Via Vetoio- 67010 Coppito (AQ), Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Arcadi
authors.affiliation: Dipartimento di Scienze Fisiche e Chimiche, Università di L'Aquila, Via Vetoio- 67010 Coppito (AQ), Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Pietropaolo
authors.affiliation: Dipartimento di Chimica, Sapienza, Università di Roma, P. le A. Moro 5, Roma, Italy.
authors.forename: Antonello
authors.initials: A
authors.lastname: Alvino
authors.affiliation: Institut de Recherche de Chimie Paris, UMR 8247, Ecole Nationale Supérieure de Chimie de Paris, Chimie ParisTech, 11 rue P. et M. Curie, F-75231 Paris Cedex 05, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Michelet
keywords: 2-alkynylanilines; fluorination; gold catalysis; indoles; tandem reactions