title: Assessment of insulin-like growth factor-1 (IGF-I) level in patients with rheumatic mitral stenosis.
abstract: OBJECTIVE
  Insulin-like growth factor-1 may serve some regulatory function in the immune system. Rheumatic mitral stenosis is related to autoimmune heart valve damage after streptococcal infection. The aim of this study was to assess the level of insulin-like growth factor-1 and its correlation with the Wilkins score in patients with rheumatic mitral stenosis.
  
  
  METHODS
  A total of 65 patients with rheumatic mitral stenosis and 62 age- and sex-matched control subjects were enrolled in this study. All subjects underwent transthoracic echocardiography. The mitral valve area and Wilkins score were evaluated for all patients. Biochemical parameters and serum insulin-like growth factor-1 levels were measured.
  
  
  RESULTS
  Demographic data were similar in the rheumatic mitral stenosis and control groups. The mean mitral valve area was 1.6±0.4 cm2 in the rheumatic mitral stenosis group. The level of insulin-like growth factor-1 was significantly higher in the rheumatic mitral stenosis group than in the control group (104 (55.6-267) versus 79.1 (23.0-244.0) ng/ml; p=0.039). There was a significant moderate positive correlation between insulin-like growth factor-1 and thickening of leaflets score of Wilkins (r=0.541, p<0.001).
  
  
  CONCLUSIONS
  The present study demonstrated that serum insulin-like growth factor-1 levels were significantly higher in the rheumatic mitral stenosis group compared with control subjects and that insulin-like growth factor-1 level was also correlated with the Wilkins score. It can be suggested that there may be a link between insulin-like growth factor-1 level and immune pathogenesis of rheumatic mitral stenosis.
authors.affiliation: 1Department of Cardiology,Cukurova University Faculty of Medicine,Adana,Turkey.
authors.forename: Onur S
authors.initials: OS
authors.lastname: Deveci
authors.affiliation: 2Department of Cardiology,Kecioren Teaching and Research Hospital,Ankara,Turkey.
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Yavuz
authors.affiliation: 2Department of Cardiology,Kecioren Teaching and Research Hospital,Ankara,Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Sen
authors.affiliation: 1Department of Cardiology,Cukurova University Faculty of Medicine,Adana,Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Deniz
authors.affiliation: 2Department of Cardiology,Kecioren Teaching and Research Hospital,Ankara,Turkey.
authors.forename: Selcuk
authors.initials: S
authors.lastname: Ozkan
authors.affiliation: 3Department of Internal Medicine,Kecioren Teaching and Research Hospital,Ankara,Turkey.
authors.forename: Kursat
authors.initials: K
authors.lastname: Dal
authors.affiliation: 3Department of Internal Medicine,Kecioren Teaching and Research Hospital,Ankara,Turkey.
authors.forename: Naim
authors.initials: N
authors.lastname: Ata
authors.affiliation: 3Department of Internal Medicine,Kecioren Teaching and Research Hospital,Ankara,Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Baser
authors.affiliation: 4Department of Biochemistry,Kecioren Teaching and Research Hospital,Ankara,Turkey.
authors.forename: Kadir O
authors.initials: KO
authors.lastname: Akin
authors.affiliation: 3Department of Internal Medicine,Kecioren Teaching and Research Hospital,Ankara,Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Kucukazman
authors.affiliation: 3Department of Internal Medicine,Kecioren Teaching and Research Hospital,Ankara,Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Beyan
authors.affiliation: 3Department of Internal Medicine,Kecioren Teaching and Research Hospital,Ankara,Turkey.
authors.forename: Derun T
authors.initials: DT
authors.lastname: Ertugrul
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology*; D012214:Rheumatic Heart Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology*; D012720:Severity of Illness Index
chemical_list: D007334:Insulin-Like Growth Factor I
keywords: Wilkins score