title: Visible-light-promoted radical C-H trifluoromethylation of free anilines.
abstract: The trifluoromethyl-substituted anilines are biologically active compounds and useful building blocks. In this communication, we have developed the first visible-light-induced radical trifluoromethylation of free anilines with the commercially available and easily handled Togni reagent at room temperature. The resulting products were successfully transformed into a variety of valuable fluorine-containing molecules and heterocyclic compounds. This protocol provides an economical and powerful route to trifluoromethylated free anilines.
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xie
authors.forename: Xiangai
authors.initials: X
authors.lastname: Yuan
authors.forename: Ablimit
authors.initials: A
authors.lastname: Abdukader
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D008027:Light; D015394:Molecular Structure
chemical_list: D000814:Aniline Compounds; D006845:Hydrocarbons, Fluorinated