title: Defective secretory-protein mRNAs take the RAPP.
abstract: Secretory proteins destined for the lumen of the endoplasmic reticulum are key regulators of cellular functions and are thus subject to several levels of quality control. A recent study finds that the earliest step in secretory protein biogenesis--binding of the signal recognition particle to the signal sequence of the nascent peptide--is subject to a quality control process termed RAPP for 'regulation of aberrant protein production'. This process involves AGO2 and mRNA degradation.
authors.affiliation: Department of Biochemistry and Biophysics, School of Medicine and Dentistry, Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA.
authors.forename: Maximilian Wei-Lin
authors.initials: MW
authors.lastname: Popp
authors.affiliation: Department of Biochemistry and Biophysics, School of Medicine and Dentistry, Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA. Electronic address: lynne_maquat@urmc.rochester.edu.
authors.forename: Lynne E
authors.initials: LE
authors.lastname: Maquat
mesh_terms: D000818:Animals; D060565:Argonaute Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D014176:Protein Biosynthesis; D021382:Protein Sorting Signals; D011506:Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D059748:Proteolysis; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D060565:Argonaute Proteins; D021382:Protein Sorting Signals; D011506:Proteins; D012333:RNA, Messenger
keywords: Argonaute 2 (AGO2); endoplasmic reticulum; mRNA degradation; quality control; regulation of aberrant protein production (RAPP); secretory protein; signal recognition particle (SRP); signal sequence