title: Gene mutations differently impact the prognosis of the myelodysplastic and myeloproliferative classes of chronic myelomonocytic leukemia.
abstract: Initially classified in the myelodysplastic syndromes (MDSs), chronic myelomonocytic leukemia (CMML) is currently considered as a MDS/myeloproliferative neoplasm. Two classes-myelodysplastic and myeloproliferative-have been distinguished upon the level of the white blood cell count (threshold 13 G/L). We analyzed mutations in 19 genes reported in CMML to determine if and how these mutations impacted the respective prognosis of the two classes. We defined four major mutated pathways (DNA methylation, ASXL1, splicing, and signaling) and determined their prognostic impact. The number of mutated pathways impacted overall survival in the myelodysplastic class but not in the myeloproliferative class. The myeloproliferative class had a worse prognosis than the myelodysplastic class and was impacted by RUNX1 mutations only. Our results argue for a reclassification of CMML based on the myelodysplastic/myeloproliferative status.
authors.affiliation: Centre de Recherche en Cancérologie de Marseille, Aix-Marseille University, Marseille, France; Laboratoire d'Oncologie Moléculaire, UMR1068 Inserm, CNRS UMR7258, Aix-Marseille University, Marseille, France; Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Cervera
authors.forename: Raphael
authors.initials: R
authors.lastname: Itzykson
authors.forename: Emilie
authors.initials: E
authors.lastname: Coppin
authors.forename: Thomas
authors.initials: T
authors.lastname: Prebet
authors.forename: Anne
authors.initials: A
authors.lastname: Murati
authors.forename: Stevan
authors.initials: S
authors.lastname: Legall
authors.forename: Norbert
authors.initials: N
authors.lastname: Vey
authors.forename: Eric
authors.initials: E
authors.lastname: Solary
authors.forename: Daniel
authors.initials: D
authors.lastname: Birnbaum
authors.forename: Véronique
authors.initials: V
authors.lastname: Gelsi-Boyer
mesh_terms: D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics; D018572:Disease-Free Survival; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000145:classification / Q000235:genetics*; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D009196:Myeloproliferative Disorders / Q000235:genetics*; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; C493728:RUNX1 protein, human