title: Hepatoblastoma and hypoplastic kidneys: a new association.
abstract: Both hepatoblastoma and hypoplastic kidneys are rare in children. A review of all patients with hepatoblastoma treated at our institution between 1993 and 2011 revealed three cases of hepatoblastoma occurring in children with hypoplastic kidneys and significantly impaired renal function. Two patients were treated with doxorubicin-based therapy without cisplatin. One was treated with carboplatin. The former two are long-term survivors while the third patient died of sepsis following chemotherapy. This association is unlikely due to chance alone and chemotherapy regimens without cisplatin may be effective in treating these children.
authors.affiliation: Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, California.
authors.forename: Randall
authors.initials: R
authors.lastname: Chan
authors.forename: Leo
authors.initials: L
authors.lastname: Mascarenhas
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Venkatramani
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage*; D018197:Hepatoblastoma / Q000150:complications / Q000151:congenital / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000150:complications / Q000151:congenital / Q000188:drug therapy / Q000473:pathology; D008297:Male; D051437:Renal Insufficiency / Q000150:complications / Q000151:congenital / Q000188:drug therapy / Q000473:pathology
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D016190:Carboplatin
keywords: cisplatin; dialysis; hepatoblastoma; hypoplastic kidneys; renal failure