title: Synthesis and the hepatoprotective activity of dibenzocyclooctadiene lignan derivatives.
abstract: The halogenated and oxidized derivatives (1a-1e, 1a'-1c', 2a-2d, 2a'-2b', 3a-3e, 3' and 3a'-3b') of schizandrin (1), schizandrin B (2) and schisanhenol (3) were synthesized. The hepatoprotective effects of these dibenzocyclooctadiene lignan analogues against CCl4-induced injury were preliminarily evaluated. Most of the analogues exhibited higher protective effects than the positive control biphenyldicarboxylate (DDB). Among these active analogues, dichloroschisanhenol (3a) exhibited the strongest protective activity (cell survival rate exceeding 98.0%).
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, PR China; College of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, Guizhou, PR China.
authors.forename: Qing-Yao
authors.initials: QY
authors.lastname: Wang
authors.affiliation: Guiyang College of Traditional Chinese Medicine, Guiyang 550002, Guizhou, PR China.
authors.forename: Jing-Zhen
authors.initials: JZ
authors.lastname: Shi
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, PR China; College of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, Guizhou, PR China.
authors.forename: Tian-Yun
authors.initials: TY
authors.lastname: Fan
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yan
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, PR China.
authors.forename: Lie-Jun
authors.initials: LJ
authors.lastname: Huang
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, PR China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Liu
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, PR China. Electronic address: haoxj@mail.kib.ac.cn.
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, PR China. Electronic address: muzi0558@126.com.
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Mu
mesh_terms: D002251:Carbon Tetrachloride; D002470:Cell Survival / Q000187:drug effects; D034242:Cyclooctanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D017705:Lignans; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D034242:Cyclooctanes; D017705:Lignans; C511097:dibenzocyclooctadiene; D002251:Carbon Tetrachloride
keywords: Dibenzocyclooctadiene lignan derivatives; Hepatoprotective effect; Schisanhenol; Schizandrin; Schizandrin B