title: Nuclear receptors and metabolism: from feast to famine.
abstract: The ability to adapt to cycles of feast and famine is critical for survival. Communication between multiple metabolic organs must be integrated to properly metabolise nutrients. By controlling networks of genes in major metabolic organs, nuclear hormone receptors (NHRs) play central roles in regulating metabolism in a tissue-specific manner. NHRs also establish daily rhythmicity by controlling the expression of core clock genes both centrally and peripherally. Recent findings show that many of the metabolic effects of NHRs are mediated through certain members of the fibroblast growth factor (FGF) family. This review focuses on the roles of NHRs in critical metabolic organs, including adipose tissue, liver and muscle, during the fed and fasted states, as well as their roles in circadian metabolism and downstream regulation of FGFs.
authors.affiliation: Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.
authors.forename: Suk-Hyun
authors.initials: SH
authors.lastname: Hong
authors.forename: Maryam
authors.initials: M
authors.lastname: Ahmadian
authors.forename: Ruth T
authors.initials: RT
authors.lastname: Yu
authors.forename: Annette R
authors.initials: AR
authors.lastname: Atkins
authors.forename: Michael
authors.initials: M
authors.lastname: Downes
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Evans
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002940:Circadian Rhythm; D005215:Fasting; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008024:Ligands; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D009132:Muscles / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D045162:Thiazolidinediones / Q000737:chemistry
chemical_list: D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D045162:Thiazolidinediones; D005346:Fibroblast Growth Factors; C089946:2,4-thiazolidinedione; D005947:Glucose