title: The contribution of sildenafil (Viagra) to ovarian stimulation with gonadotropins in a woman with poor ovarian response.
abstract: We aim to present the first case of a pregnancy achieved by administering sildenafil (Viagra) to a woman not responding to controlled ovarian hyperstimulation (COH) with the sole use of gonadotropins. A 37-year-old woman underwent COH, as part of an intracytoplasmic sperm injection (ICSI) cycle, with the combination of r-FSH and HMG for 13 d, without evidence of follicular growth. The addition of oral sildenafil at a dose of 50 mg per day for a total of five doses improved the ovarian response and resulted in the retrieval of 10 oocytes. Three embryos were transferred to the uterine cavity resulting in a successful pregnancy and, eventually, the delivery of a healthy neonate. Conclusively, the use of sildenafil as an adjunct to COH protocols may enhance ovarian response in a woman with poor ovarian response (POR) and merits further research.
authors.affiliation: Third Department of Obstetrics and Gynecology, University of Athens Medical School, Attikon General University Hospital , Athens , Greece and.
authors.forename: Eftihios
authors.initials: E
authors.lastname: Trakakis
authors.forename: Vassilios
authors.initials: V
authors.lastname: Vaggopoulos
authors.forename: Vasileios D
authors.initials: VD
authors.lastname: Sioulas
authors.forename: Periklis
authors.initials: P
authors.lastname: Panagopoulos
authors.forename: Ioannis
authors.initials: I
authors.lastname: Grammatikakis
authors.forename: Peny
authors.initials: P
authors.lastname: Ambatzi
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kassanos
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D006080:Ovarian Follicle / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D010879:Piperazines / Q000008:administration & dosage*; D011247:Pregnancy; D011687:Purines / Q000008:administration & dosage; D000068677:Sildenafil Citrate; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods; D013449:Sulfonamides / Q000008:administration & dosage*; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D010879:Piperazines; D011687:Purines; D013449:Sulfonamides; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate
keywords: Controlled ovarian hyperstimulation; poor ovarian response; sildenafil