title: Factors influencing survival in acinic cell carcinoma: a retrospective survival analysis of 2061 patients.
abstract: BACKGROUND
  Acinic cell carcinoma is an uncommon salivary neoplasm with clinical and histologic features known to influence prognosis. The purpose of this study was to further describe variables influencing survival in a large cohort of patients with acinic cell carcinoma.
  
  
  METHODS
  Using the Surveillance, Epidemiology, and End Results (SEER) registry, we obtained demographic, clinicopathologic, and treatment data pertaining to patients diagnosed with acinic cell carcinoma. Kaplan-Meier and Cox regression analyses were performed to compare survival with various clinical and pathological parameters.
  
  
  RESULTS
  We identified 2061 patients with acinic cell carcinoma from 1973 to 2009. Sex, staging, grade, subsite, and treatment were significant predictors of disease-specific survival (DSS). Patients who received surgery alone had the highest 20-year DSS (92.4%), followed by those treated with surgery and radiation (71.9%) or radiation alone (62.3%).
  
  
  CONCLUSIONS
  Our results suggest that histologic grade is a stronger predictor of survival than TNM classification, survival after surgical resection alone is excellent, and adjuvant radiation may be of limited benefit
authors.affiliation: Department of Otolaryngology, University of California Davis, Sacramento, California.
authors.forename: Vincent L
authors.initials: VL
authors.lastname: Biron
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Lentsch
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.|Mercer University School of Medicine, Savannah, Georgia.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Gerry
authors.affiliation: Department of Otolaryngology, University of California Davis, Sacramento, California.
authors.forename: Arnaud F
authors.initials: AF
authors.lastname: Bewley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D018267:Carcinoma, Acinar Cell / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D018426:SEER Program; D012468:Salivary Gland Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D016019:Survival Analysis
keywords: acinic cell carcinoma; grade; surgery; survival; treatment