title: Guttate psoriasis is associated with an intermediate phenotype of impaired Langerhans cell migration.
abstract: BACKGROUND
  An episode of guttate psoriasis can be an isolated event, can recur as guttate episodes, or develop into chronic plaque psoriasis (CPP). A previous study revealed that early-onset (before age 40 years) CPP is associated with inhibition of epidermal Langerhans cell (LC) migration.
  
  
  OBJECTIVE
  To determine whether guttate psoriasis is also associated with abnormal LC mobilization.
  
  
  METHODS
  Three groups of patients were recruited: current guttate episode (n = 5); guttate psoriasis progressed to CPP (n = 6); and resolved guttate psoriasis (n = 2). Biopsies were taken from uninvolved skin and LC migration was measured ex vivo using an epidermal explant model.
  
  
  RESULTS
  Patients with a current episode of guttate psoriasis displayed epidermal LC migration, although the extent was significantly lower than in skin from healthy controls (P < 0·05). In contrast, in those patients in whom guttate psoriasis developed into CPP there was no mobilization of LC. Finally, in patients in whom guttate psoriasis had resolved, LC migration was normal.
  
  
  CONCLUSIONS
  We have shown that guttate psoriasis is associated with an abnormality of LC mobilization, but a less marked inhibition compared with that seen in CPP. In resolved guttate psoriasis LC function returns to normal. These data provide further evidence that the pathogenesis of psoriasis is characterized by significant changes in epidermal LC function.
authors.affiliation: Faculty of Life Sciences, Salford Royal Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester, U.K.
authors.forename: L H
authors.initials: LH
authors.lastname: Eaton
authors.forename: L
authors.initials: L
authors.lastname: Chularojanamontri
authors.forename: F R
authors.initials: FR
authors.lastname: Ali
authors.forename: E
authors.initials: E
authors.lastname: Theodorakopoulou
authors.forename: R J
authors.initials: RJ
authors.lastname: Dearman
authors.forename: I
authors.initials: I
authors.lastname: Kimber
authors.forename: C E M
authors.initials: CE
authors.lastname: Griffiths
mesh_terms: D000328:Adult; D002465:Cell Movement / Q000502:physiology*; D005260:Female; D006801:Humans; D007801:Langerhans Cells / Q000502:physiology*; D008297:Male; D010641:Phenotype; D011565:Psoriasis / Q000473:pathology*