title: The association between VDR polymorphisms and renal cell carcinoma susceptibility: a meta-analysis.
abstract: Vitamin D receptor (VDR) gene polymorphisms have previously been associated with susceptibility to renal cell carcinoma, although the findings are inconsistent. This study therefore evaluated the association of three single nucleotide polymorphisms (SNPs) in VDR (FokI, BsmI, and TaqI) with the risk of renal cell carcinoma in five previous studies of a total of 1,510 cases and 2,101 controls identified from PubMed, Web of Science, Embase, and Wanfang databases. Pooled odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were calculated, and stratified analysis by ethnicity was conducted for further estimation. All statistical analyses were conducted using STATA software. Obvious heterogeneity was noted among the five studies. The VDR BsmI polymorphism was not found to be associated with renal cell carcinoma risk, although subgroup analysis revealed a significant association with renal cell carcinoma risk in Asians (b vs B OR=1.479, 95 % CI=1.171-1.869, P OR=0.001 and bb vs BB OR=2.608, 95 % CI=1.529-4.449, P OR=0.001). No significant association was found between renal cell carcinoma risk and either FokI or TaqI polymorphisms in different models and populations. Further large-scale studies are required to confirm these conclusions.
authors.affiliation: Molecular Oncology Department of Cancer Research Institution, The First Hospital of China Medical University, 110001, Shenyang, China.
authors.forename: Fandong
authors.initials: F
authors.lastname: Meng
authors.forename: Ping
authors.initials: P
authors.lastname: Ma
authors.forename: Chengguang
authors.initials: C
authors.lastname: Sui
authors.forename: Xin
authors.initials: X
authors.lastname: Tian
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Liye
authors.initials: L
authors.lastname: Fu
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Youhong
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D002292:Carcinoma, Renal Cell / Q000209:etiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D018167:Receptors, Calcitriol / Q000235:genetics*; D012306:Risk
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human