title: Evaluation of a Pseudoceramide Moisturizer in Patients with Mild-to-Moderate Atopic Dermatitis.
abstract: BACKGROUND
  To evaluate the efficacy and safety of a pseudoceramide-containing moisturizer as maintenance therapy in patients with mild-to-moderate atopic dermatitis (AD).
  
  
  METHODS
  This was a prospective, single-arm, open-label clinical trial of a twice-daily application of a pseudoceramide-containing moisturizer for 4 weeks as maintenance therapy in 40 patients with stable, mild-to-moderate AD in a tropical climate. Clinical and skin barrier assessment was done at week 0, week 2 and week 4. Any adverse effects were also recorded during the study period.
  
  
  RESULTS
  The objective scoring atopic dermatitis decreased from 29.1 [interquartile range (IQR) 21.9-33.7] at week 0 to 22.0 (IQR 21.2-27.8) at week 4 (p < 0.001). There was no detectable difference in transepidermal water loss after 4 weeks; however, stratum corneum (SC) hydration was significantly increased from 39.7 (IQR 35.3-46.4) at week 0 to 49.2 (IQR 41.2-54.6) after 4 weeks (p < 0.001). Both Dermatology Life Quality Index and patient-oriented eczema measure showed significant improvement at week 4 (p < 0.001). The moisturizer was well tolerated with no serious adverse events recorded.
  
  
  CONCLUSIONS
  After 4 weeks of barrier maintenance therapy with a pseudoceramide moisturizer, there was a significant improvement in disease severity, SC hydration and quality of life in both pediatric and adult patients with mild-to-moderate AD.
authors.affiliation: National Skin Center, 1 Mandalay Road, Novena, Singapore.
authors.forename: Amelie Clementine
authors.initials: AC
authors.lastname: Seghers
authors.forename: Sophie Chan
authors.initials: SC
authors.lastname: Cai
authors.forename: Madeleine Sheun Ling
authors.initials: MS
authors.lastname: Ho
authors.forename: Yoke Chin
authors.initials: YC
authors.lastname: Giam
authors.forename: Lucinda
authors.initials: L
authors.lastname: Tan
authors.forename: Carina Marie
authors.initials: CM
authors.lastname: Grönhagen
authors.forename: Mark Boon Yang
authors.initials: MB
authors.lastname: Tang