title: Metformin-induced lactic acidosis associated with multiorganic failure.
abstract: Lactic acidosis is a rare but severe complication in patients with type 2 diabetes treated with metformin. Patients with lactic acidosis show commonly signs of shock, tissue hypoxia, acute hepatic or renal failure and the link between metformin therapy and lactic acidosis may be coincidental, associated or causal. Excessive plasma metformin concentrations show that lactic acidosis is due to a toxicological mechanism. We report a case of severe multiorganic failure in a subject after treatment with high doses of metformin.
authors.affiliation: Service of Nephrology, UHC "Mother Teresa", Tirana, Albania. ebolleku@gmail.com
authors.forename: Eriola
authors.initials: E
authors.lastname: Bolleku
authors.affiliation: Service of Nephrology, UHC "Mother Teresa", Tirana, Albania.
authors.forename: Alma
authors.initials: A
authors.lastname: Idrizi
authors.affiliation: Service of Nephrology, UHC "Mother Teresa", Tirana, Albania.
authors.forename: Myftar
authors.initials: M
authors.lastname: Barbullushi
authors.affiliation: Service of Nephrology, UHC "Mother Teresa", Tirana, Albania.
authors.forename: Valbona
authors.initials: V
authors.lastname: Bajrami
authors.affiliation: Service of Cardiosurgery, UHC "Mother Teresa", Tirana, Albania.
authors.forename: Ermal
authors.initials: E
authors.lastname: Likaj
authors.affiliation: Service of Nephrology, UHC "Mother Teresa", Tirana, Albania.
authors.forename: Nestor
authors.initials: N
authors.lastname: Thereska
authors.affiliation: Intensive Care Unit, UHC "Mother Teresa", Tirana, Albania.
authors.forename: Ilir
authors.initials: I
authors.lastname: Ohri
authors.affiliation: Intensive Care Unit, UHC "Mother Teresa", Tirana, Albania.
authors.forename: Lordian
authors.initials: L
authors.lastname: Nunci
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000150:complications; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008687:Metformin / Q000009:adverse effects*; D009102:Multiple Organ Failure / Q000139:chemically induced* / Q000209:etiology
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin