title: The role of Cbln1 on Purkinje cell synapse formation.
abstract: Cbln1 is a glycoprotein which belongs to the C1q family. In the cerebellum, Cbln1 is produced and secreted from granule cells and works as a strong synapse organizer between Purkinje cells and parallel fibers, the axons of the granule cells. In this update article, we will describe the molecular mechanisms by which Cbln1 induces synapse formation and will review our findings on the axonal structural changes which occur specifically during this process. We will also describe our recent finding that Cbln1 has a suppressive role in inhibitory synapse formation between Purkinje cells and molecular layer interneurons. Our results have revealed that Cbln1 plays an essential role to establish parallel fiber-Purkinje cell synapses and to regulate balance between excitatory and inhibitory input on Purkinje cells.
authors.affiliation: Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan; Department of Physiology, School of Medicine, Keio University, Tokyo 160-8582, Japan. Electronic address: aitou-tky@umin.ac.jp.
authors.forename: Aya
authors.initials: A
authors.lastname: Ito-Ishida
authors.affiliation: Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Okabe
authors.affiliation: Department of Physiology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Michisuke
authors.initials: M
authors.lastname: Yuzaki
mesh_terms: D000818:Animals; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology; D011498:Protein Precursors / Q000378:metabolism*; D011689:Purkinje Cells / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*
chemical_list: C092370:Cbln1 protein, mouse; D009419:Nerve Tissue Proteins; D011498:Protein Precursors
keywords: Cbln1; Cerebellum; Purkinje cell; Synapse formation