title: Challenges in diagnosing adhesive small bowel obstruction.
abstract: Adhesive small bowel obstruction (ASBO) is the most frequently encountered surgical disorder of the small intestine. Up to 80% of ASBO cases resolve spontaneously and do not require invasive treatment. It is important to identify such patients that will benefit from conservative treatment in order to prevent unnecessarily exposing them to the risks associated with surgical intervention, such as morbidity and further adhesion formation. For the remaining ASBO patients, timely surgical intervention is necessary to prevent small bowel strangulation, which may cause intestinal ischemia and bowel necrosis. While early identification of these patients is key to decreasing ASBO-related morbidity and mortality, the non-specific signs and laboratory findings upon clinic presentation limit timely diagnosis and implementation of appropriate clinical management. Combining the clinical presentation findings with those from other diagnostic imaging modalities, such as abdominal X-ray, computed tomography-scan and water-soluble contrast studies, will improve diagnosis of ASBO and help clinicians to better evaluate the potential of conservative management as a safe strategy for a particular patient. Nonetheless, patients who present with moderate findings by all these approaches continue to represent a challenge. A new diagnostic strategy is urgently needed to further improve our ability to identify early signs of strangulated bowel, and this diagnostic modality should be able to indicate when surgical management is required. A number of potential serum markers have been proposed for this purpose, including intestinal fatty acid binding protein and α-glutathione S transferase. On-going research is attempting to clearly define their diagnostic utility and to optimize their potential role in determining which patients should be managed surgically.
authors.affiliation: Thijs R van Oudheusden, Ignace HJT de Hingh, Misha DP Luyer, Department of Surgery, Catharina Hospital, 5623 EJ, Eindhoven, The Netherlands.
authors.forename: Thijs R
authors.initials: TR
authors.lastname: van Oudheusden
authors.affiliation: Thijs R van Oudheusden, Ignace HJT de Hingh, Misha DP Luyer, Department of Surgery, Catharina Hospital, 5623 EJ, Eindhoven, The Netherlands.
authors.forename: Bart Ac
authors.initials: BA
authors.lastname: Aerts
authors.affiliation: Thijs R van Oudheusden, Ignace HJT de Hingh, Misha DP Luyer, Department of Surgery, Catharina Hospital, 5623 EJ, Eindhoven, The Netherlands.
authors.forename: Ignace Hjt
authors.initials: IH
authors.lastname: de Hingh
authors.affiliation: Thijs R van Oudheusden, Ignace HJT de Hingh, Misha DP Luyer, Department of Surgery, Catharina Hospital, 5623 EJ, Eindhoven, The Netherlands.
authors.forename: Misha Dp
authors.initials: MD
authors.lastname: Luyer
mesh_terms: D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D007415:Intestinal Obstruction / Q000175:diagnosis* / Q000628:therapy; D007421:Intestine, Small / Q000473:pathology / Q000601:surgery*; D018579:Patient Selection; D011237:Predictive Value of Tests; D012086:Reoperation; D012307:Risk Factors; D000267:Tissue Adhesions; D016896:Treatment Outcome
keywords: Adhesive small bowel obstruction; Biological markers; Clinical management; Diagnosis; Intestinal fatty acid binding protein; α-glutathione S transferase