title: Gold nanoparticles for nucleic acid delivery.
abstract: Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies. We also discuss challenges in nucleic acid delivery, including endosomal entrapment/escape and active delivery/presentation of nucleic acids in the cell.
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA; Department of Pharmaceutical Analysis, Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing, Jiangsu, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA.
authors.forename: Ziwen
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA.
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Saha
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA.
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Kim
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA.
authors.forename: Sung Tae
authors.initials: ST
authors.lastname: Kim
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA.
authors.forename: Ryan F
authors.initials: RF
authors.lastname: Landis
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA. Electronic address: rotello@chem.umass.edu.
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D016503:Drug Delivery Systems; D015316:Genetic Therapy; D006046:Gold; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D008958:Models, Molecular; D009696:Nucleic Acids / Q000627:therapeutic use*
chemical_list: D009696:Nucleic Acids; D006046:Gold