title: Coupling interval dispersion and body mass index are independent predictors of idiopathic premature ventricular complex-induced cardiomyopathy.
abstract: BACKGROUND
  Patients with frequent premature ventricular complexes (PVCs) might be at risk for the developing or exacerbation of left ventricular (LV) dysfunction. However, some patients with a high-PVC burden do not develop cardiomyopathy, while other patients with low-PVC burden can develop cardiomyopathy. The purpose of this study was to evaluate the positive predictors of idiopathic PVCs-induced cardiomyopathy.
  
  
  RESULTS
  We investigated 214 patients undergoing successful ablation of PVCs who had no other causes of cardiomyopathy. We divided the study cohort into 2 groups: ejection fraction (EF) ≥ 50% (normal LV) and EF < 50% (LV dysfunction). We analyzed the clinical characteristics, including the electrocardiogram and findings at electrophysiology study. Among these patients, 51 (24%) had reduced LVEF and 163 (76%) had normal LV function. Patients with LV dysfunction had significantly longer coupling interval (CI) dispersion (maximum-CI-minimum-CI) and had significantly higher PVC burden compared to those with normal LV function (CI-dispersion: 115 ± 25 milliseconds vs. 94 ± 19 milliseconds; P < 0.001; PVC burden: 19% vs. 15%; P = 0.04). Furthermore, patients with LV dysfunction had significantly higher body mass index (BMI) compared to those with normal LV function (BMI > 30 kg/m(2) ; 37% vs. 13%; P = 0.001). Logistic regression analysis showed that CI-dispersion, PVC burden, and BMI (>30 kg/m(2) ) are independent predictors of PVC-induced cardiomyopathy.
  
  
  CONCLUSIONS
  In addition to the PVC burden, the CI-dispersion and BMI are associated with PVC-induced cardiomyopathy.
authors.affiliation: Division of Cardiology, University of California, San Francisco, California, USA.
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Kawamura
authors.forename: Nitish
authors.initials: N
authors.lastname: Badhwar
authors.forename: Vasanth
authors.initials: V
authors.lastname: Vedantham
authors.forename: Zian H
authors.initials: ZH
authors.lastname: Tseng
authors.forename: Byron K
authors.initials: BK
authors.lastname: Lee
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Lee
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Marcus
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Olgin
authors.forename: Edward P
authors.initials: EP
authors.lastname: Gerstenfeld
authors.forename: Melvin M
authors.initials: MM
authors.lastname: Scheinman
mesh_terms: D000200:Action Potentials; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D017115:Catheter Ablation; D016009:Chi-Square Distribution; D015716:Electrocardiography, Ambulatory; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013318:Stroke Volume; D013997:Time Factors; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016277:Ventricular Function, Left; D018879:Ventricular Premature Complexes / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery
keywords: PVC burden; body mass index; cardiomyopathy; catheter ablation; premature ventricular complexes; ventricular arrhythmia