title: A Novel HIV-1 CRF01_AE/B recombinant among men who have sex with men in Jiangsu Province, China.
abstract: CRF01_AE and subtype B are the two of major HIV-1 clades circulating in China. HIV spread more rapidly among men who have sex with men (MSM) than among populations with other risk behaviors. In Jiangsu province in China, the HIV-1 incidence among MSM was more than 3.8%. Our previous study showed that almost equal proportions of CRF01_AE, B, and CRF07_BC were circulating among MSM. Moreover, many kinds of CRF01Bs have been identified among MSM in Southeast Asia in recent years. It is therefore inevitable that recombination between CRF01_AE and subtype B will emerge among MSM in Jiangsu province in China. Here we identify a novel recombinant of CRF01_AE/B that has a distinctly different genome structure from other CRF01Bs and unique recombinant forms (URFs) previously identified. An analysis of the near full-length sequence of JS2010001 showed that it is composed of at least three interlaced CRF01_AE and B segments. Recently, many kinds of URFs and C circulating recombinant forms (CRFs) have emerged among MSM in China within a short period of time, which suggests that dual infection of HIV-1 among MSM in China is very common and that more effective intervening measures to prevent the spread of HIV among MSM should be taken.
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention , Nanjing, China .
authors.forename: Hongxiong
authors.initials: H
authors.lastname: Guo
authors.forename: Haiyang
authors.initials: H
authors.lastname: Hu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.forename: Haitao
authors.initials: H
authors.lastname: Yang
authors.forename: Xiping
authors.initials: X
authors.lastname: Huan
authors.forename: Tao
authors.initials: T
authors.lastname: Qiu
authors.forename: Gengfeng
authors.initials: G
authors.lastname: Fu
authors.forename: Ping
authors.initials: P
authors.lastname: Ding
mesh_terms: D001483:Base Sequence; D018791:CD4 Lymphocyte Count; D002681:China / Q000453:epidemiology; D014644:Genetic Variation; D016679:Genome, Viral / Q000235:genetics*; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D016415:Sequence Alignment; D017423:Sequence Analysis, RNA; D011795:Surveys and Questionnaires
chemical_list: D012367:RNA, Viral