title: [Dexamethasone and diclofenac by LC-MS-MS as herbal product adulterants].
abstract: OBJECTIVE
  To confirm the presence of dexamethasone and diclofenac as adulterants of an herbal product.
  
  
  METHODS
  For identificaction and confirmation of drugs a method of instrumental analysis by liquid chromatography coupled with high pressure tandem mass spectrometry was used.
  
  
  RESULTS
  The presence of dexamethasone and diclofenac was confirmed in samples of 11 bottles of Reumofan Plus obtained from patients and/or physicians. The methodology used, allowed separation of stereoisomers dexamethasone and betamethasone, the relative abundances of product ions 237.2 and 279.2 m / z spectrally differentiate the compounds.
  
  
  CONCLUSIONS
  The presence of dexamethasone and diclofenac was confirmed in samples of a product marketed as "100% natural" obtained from patients and / or physicians in a period from January to December, 2011.
authors.affiliation: Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, México.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Garza-Ocañas
authors.affiliation: Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, México.
authors.forename: Christian Tadeo
authors.initials: CT
authors.lastname: Badillo-Castañeda
authors.affiliation: Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, México.
authors.forename: Sandra Lucía
authors.initials: SL
authors.lastname: Montoya-Eguía
authors.affiliation: Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, México.
authors.forename: Pedro Lennon
authors.initials: PL
authors.lastname: Saenz-Chávez
authors.affiliation: Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, México.
authors.forename: Humberto
authors.initials: H
authors.lastname: Garza-Ulloa
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002853:Chromatography, Liquid; D003907:Dexamethasone / Q000032:analysis*; D004008:Diclofenac / Q000032:analysis*; D004340:Drug Contamination; D005938:Glucocorticoids / Q000032:analysis*; D028321:Plant Preparations / Q000737:chemistry*; D053719:Tandem Mass Spectrometry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D028321:Plant Preparations; D004008:Diclofenac; D003907:Dexamethasone