title: Latest concept of Lewy body disease.
abstract: We proposed the term 'Lewy body disease' (LBD) in 1980. Subsequently, we classified LBD into three types according to the distribution pattern of Lewy bodies: a brainstem type, a transitional type and a diffuse type. Later, we added the cerebral type. As we have proposed since 1980, LBD has recently been used as a generic term, including Parkinson's disease, Parkinson's disease with dementia and dementia with Lewy bodies. LBD has neuropathological characteristics whereby numerous Lewy bodies are present in the central and sympathetic nervous systems, and it is a type of alpha-synucleinopathy because the main component of Lewy body is alpha-synuclein. In this paper we explain the most recent concept of LBD from the historical viewpoint.
authors.affiliation: Medical Care Court Clinic, Yokohama, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kosaka
mesh_terms: D001921:Brain / Q000473:pathology; D006801:Humans; D020961:Lewy Body Disease / Q000473:pathology*; D010300:Parkinson Disease / Q000473:pathology; D009626:Terminology as Topic
keywords: Lewy body disease; Parkinson's disease; Parkinson's disease with dementia; dementia with Lewy bodies; diffuse Lewy body disease