title: Chitosan-triphosphate nanoparticles for encapsulation of super-paramagnetic iron oxide as an MRI contrast agent.
abstract: Super-paramagnetic iron oxide nanoparticles (SPIONPs) were encapsulated at various concentrations within chitosan-triphosphate (SPIONPs-CS) nanoparticles using an ionotropic gelation method. The encapsulation of SPIONPs within CS nanoparticles enhanced their dispersion ability in aqueous solution, with all particles being lower than 130 nm in size and having highly positive surface charge. The SPIONPs-CS nanoparticles exhibited crystalline structure and super-paramagnetic behavior, as seen in non-encapsulated SPIONPs. The morphology of SPIONPs-CS nanoparticles showed that they almost spherical in shape. The effect of phantom environments (culture medium and 3% agar solution) on either T1 or T2 weighted MRI was investigated using a clinical 1.5T MRI scanner. The results revealed that 3% agar solution showed relaxation values higher than the culture medium, leading to a significant decrease in the MR image intensity. Our results demonstrated that the SPIONPs-CS nanoparticles can be applied as tissue-speciﬁc MRI contrast agents.
authors.affiliation: Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
authors.forename: Chutimon
authors.initials: C
authors.lastname: Sanjai
authors.affiliation: Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address: suchart@chiangmai.ac.th.
authors.forename: Suchart
authors.initials: S
authors.lastname: Kothan
authors.affiliation: Nanodelivery System Laboratory, National Nanotechnology Center, National Science and Technology Development Agency, Pathumthani, 10120, Thailand.
authors.forename: Pattarapond
authors.initials: P
authors.lastname: Gonil
authors.affiliation: Nanodelivery System Laboratory, National Nanotechnology Center, National Science and Technology Development Agency, Pathumthani, 10120, Thailand.
authors.forename: Somsak
authors.initials: S
authors.lastname: Saesoo
authors.affiliation: Nanodelivery System Laboratory, National Nanotechnology Center, National Science and Technology Development Agency, Pathumthani, 10120, Thailand. Electronic address: warayuth@nanotec.or.th.
authors.forename: Warayuth
authors.initials: W
authors.lastname: Sajomsang
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D003287:Contrast Media / Q000737:chemistry* / Q000494:pharmacology; D005290:Ferric Compounds / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide; D048271:Chitosan
keywords: Chitosan; Chitosan-TPP nanoparticles; Encapsulation; Magnetic resonance imaging (MRI); Super-paramagnetic iron oxide nanoparticles