title: Glycodelin A - a famous lipocalin and its role in breast cancer.
abstract: Lipocalins are a large protein family with only little sequence homology but highly conserved structural similarity. Many lipocalins play crucial roles in the generation of epithelial cancer, influencing pathways which regulate cell motility, cell differentiation and neovascularisation. Thereby they can be used as biomarkers of cancer, in most cases for a rather good prognosis. Glycodelin is a lipocalin existing in three isoforms which differ only by glycosylation, but which have different functions. In breast cancer, glycodelin A is known to contribute to a more differentiated cell morphology and is a biomarker for a favourable prognosis, but also plays a role in angiogenesis. Glycodelin A is a useful prognostic marker as it can be detected in serum samples, but is also a target for therapeutical interventions.
authors.affiliation: Department of Obstetrics and Gynaecology, Ludwig Maximilian University of Munich, Maistrasse 11, D-80337 Munich, Germany. udo.jeschke@med.uni-muenchen.de.
authors.forename: Alexandra C
authors.initials: AC
authors.lastname: Kölbl
authors.forename: Udo
authors.initials: U
authors.lastname: Jeschke
authors.forename: Darius
authors.initials: D
authors.lastname: Dian
authors.forename: Klaus
authors.initials: K
authors.lastname: Friese
authors.forename: Ulrich
authors.initials: U
authors.lastname: Andergassen
mesh_terms: D001943:Breast Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D009389:Neovascularization, Pathologic
chemical_list: D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human
keywords: Glycodelin; breast cancer; immunosuppression; lipocalin; review