title: Reconstruction of large-size abdominal wall defect using biodegradable poly-p-dioxanone mesh: an experimental canine study.
abstract: BACKGROUND
  Reconstruction of large-size abdominal wall defect (AWDs) is a huge challenge faced in current surgical practice. In this study, we aimed to evaluate the effectiveness and safety of biodegradable poly-p-dioxanone (PDO) mesh for reconstructing large-size AWDs in an experimental canine model.
  
  
  METHODS
  Eighteen experimental canines were randomly and equally divided into three groups, namely, a PDO group, a Marlex group and a control group (n = 6 each). Following the creation of a 6 cm × 5.5 cm AWD, PDO mesh and Marlex mesh were used to reconstruct the defect in the PDO and Marlex groups, respectively. The defect was closed using relaxation sutures alone in the control group. Animals were killed 24 weeks after surgery, and reconstruction outcomes were evaluated using radiography, histology and biomechanical testing.
  
  
  RESULTS
  All animals except those in the control group survived the experiment. The PDO group showed no wound dehiscence, herniation or infection, whereas the animals in the Marlex group exhibited marked foreign body reactions. The PDO group had less intraabdominal adhesion than the Marlex group. As shown by radiography, histology and biomechanical testing, PDO mesh exhibited complete degradation and favorable biochemical strength at 24 weeks postsurgery.
  
  
  CONCLUSIONS
  PDO mesh implantation is an effective, safe treatment modality for reconstructing large-size AWDs.
authors.forename: Kenan
authors.initials: K
authors.lastname: Huang
authors.forename: Xinyu
authors.initials: X
authors.lastname: Ding
authors.forename: Benbo
authors.initials: B
authors.lastname: Lv
authors.forename: Linyun
authors.initials: L
authors.lastname: Wei
authors.forename: Juxian
authors.initials: J
authors.lastname: Sun
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Changzheng Hospital, the Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. Qin-Xiong@163.com.
authors.forename: Xiong
authors.initials: X
authors.lastname: Qin
authors.forename: Hua
authors.initials: H
authors.lastname: Tang
mesh_terms: D034861:Abdominal Wall / Q000473:pathology* / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001696:Biomechanical Phenomena; D004146:Dioxanes / Q000737:chemistry*; D004285:Dogs; D005260:Female; D008297:Male; D011108:Polymers / Q000737:chemistry*; D019651:Plastic Surgery Procedures; D013526:Surgical Mesh; D014057:Tomography, X-Ray Computed; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D004146:Dioxanes; D011108:Polymers; C079733:poly-4-dioxan-2-one