title: Phosphorus(V)-corrole: synthesis, spectroscopic properties, theoretical calculations, and potential utility for in vivo applications in living cells.
abstract: The synthesis and properties of phosphorus(V) 5,10,15-tris(4-methoxycarbonylphenyl)corrole (1) have been investigated, and its potential utility for bioimaging applications in living cells has been explored. As would normally be anticipated for corrole complexes, the intensity of the Q(0,0) bands of 1 is greater than those of comparable phosphorus(V) tetraphenylporphyrins, but the ΦF values (0.25 for 1) are found to be comparable. A detailed analysis of the electronic structure of the complex was carried out by comparing electronic absorption and MCD spectral data to the results of TD-DFT calculations. The meso-aryl substituents, which enhance the lipophilicity of 1 and hence result in its localization in intracellular membranes during HeLa cell experiments, are predicted to result in a narrowing of the HOMO-LUMO gap and hence a red shift of the Q(0,0) bands toward the optical window in biological tissues.
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University , Sendai 980-8578, Japan.
authors.forename: Xu
authors.initials: X
authors.lastname: Liang
authors.forename: John
authors.initials: J
authors.lastname: Mack
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Zheng
authors.forename: Zhen
authors.initials: Z
authors.lastname: Shen
authors.forename: Nagao
authors.initials: N
authors.lastname: Kobayashi
mesh_terms: D018613:Microscopy, Confocal; D010758:Phosphorus / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D011166:Porphyrins; C431863:corrole; D010758:Phosphorus