title: [Abnormal immunity in IgG4-related autoimmune pancreatitis].
abstract: Recently, autoimmune pancreatitis (AIP) has been classified into two subtypes: type 1 as a pancreatic manifestation of IgG4-related disease (IgG4-RD), and type 2 related with a granulocytic epithelial lesion (GEL). Different from type 2 AIP, T helper type 2 (Th2) immune response is predominant over Th1 in type 1/IgG4-RD. Recent human and experimental animal studies have suggested a possible involvement of innate immunity in addition to acquired immunity, such as genetic background, bacterial/viral infections, complement activation via classical pathway, or IgG4-production of monocytes/basophils with TLR/NOD stimulation. Based on these findings, we have proposed a hypothesis for the development of type 1 AIP, one of the IgG4-RD.
authors.affiliation: The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University.
authors.forename: Kazuichi
authors.initials: K
authors.lastname: Okazaki
authors.forename: Kimi
authors.initials: K
authors.lastname: Sumimoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Mitsuyama
authors.forename: Kazushige
authors.initials: K
authors.lastname: Uchida
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007113:Immunity, Innate; D007074:Immunoglobulin G / Q000276:immunology*; D010195:Pancreatitis / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G