title: Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center.
abstract: The Interleukin-23 signalling pathway is important for the differentiation of TH17 lymphocytes and is involved in the pathogenesis of Inflammatory bowel disease. Polymorphisms in the IL-23 receptor gene were previously found to be associated with Inflammatory bowel disease in various populations. The aim of this study was to determine whether the specific rs11209026 and rs7530511 single-nucleotide polymorphisms in the Interleukin-23 receptor gene are associated with Crohn's disease and ulcerative colitis in a Croatian patient population. A total of 50 patients with Crohn's disease and 93 patients with ulcerative colitis, as well as 99 healthy control subjects were included in the study. The results determined a significantly higher occurrence of rs11209026 in control group compared to patients with inflammatory bowel disease, suggesting a protective effect of this polymorphism. The rs11209026 variant was strongly associated with Crohn's disease, but it was absent in ulcerative colitis. However, there was no significant association between the rs7530511 polymorphism with either ulcerative colitis or Crohn's disease. Associations presented in this study give potentially important insight into the roles of specific Interleukin-23 receptor polymorphisms in Crohn's disease pathogenesis in the Croatian population.
authors.affiliation: University Josip Juraj Strossmayer, University Hospital Centre Osijek, Internal Medicine Clinic, Division of Gastroenterology, Osijek, Croatia.
authors.forename: Silvio
authors.initials: S
authors.lastname: Mihaljević
authors.affiliation: University Josip Juraj Strossmayer, University Hospital Centre Osijek, Internal Medicine Clinic, Division of Gastroenterology, Osijek, Croatia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Kibel
authors.affiliation: University Josip Juraj Strossmayer, University Hospital Centre Osijek, Clinic for Nuclear medicine and Radiation Protection, Osijek, Croatia.
authors.forename: Mario
authors.initials: M
authors.lastname: Stefanić
authors.affiliation: University Josip Juraj Strossmayer, School of Medicine, Department of Chemistry and Biochemistry, Osijek, Croatia.
authors.forename: Ljubica
authors.initials: L
authors.lastname: Glavas-Obrovac
authors.affiliation: University Josip Juraj Strossmayer, University Hospital Centre Osijek, Clinic for Nuclear medicine and Radiation Protection, Osijek, Croatia.
authors.forename: Boris
authors.initials: B
authors.lastname: Takac
authors.affiliation: University of Zagreb, University Hospital Centre Zagreb, Internal Medicine Clinic, Division of Gastroenterology and Hepatology, Zagreb, Croatia.
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Krznarić
authors.affiliation: University Josip Juraj Strossmayer, University Hospital Centre Osijek, Department of Transfusion Medicine, Osijek, Croatia.
authors.forename: Marina
authors.initials: M
authors.lastname: Samardiija
authors.affiliation: University Josip Juraj Strossmayer, University Hospital Centre Osijek, Pediatric Clinic, Osijek, Croatia.
authors.forename: Ljerka
authors.initials: L
authors.lastname: Pinotić
authors.affiliation: Department of Public Health, Osijek, Croatia.
authors.forename: Josip
authors.initials: J
authors.lastname: Milas
authors.affiliation: University Josip Juraj Strossmayer, University Hospital Centre Osijek, Internal Medicine Clinic, Division of Gastroenterology, Osijek, Croatia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Segec
mesh_terms: D000328:Adult; D001483:Base Sequence; D016022:Case-Control Studies; D017523:Croatia; D017931:DNA Primers; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D053759:Interleukin-23 / Q000378:metabolism*; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics* / Q000378:metabolism; D062606:Tertiary Care Centers; D055815:Young Adult
chemical_list: D017931:DNA Primers; D053759:Interleukin-23; D018123:Receptors, Interleukin