title: Three-dimensional volumetric human meibomian gland investigation using polarization-sensitive optical coherence tomography.
abstract: In this study, polarization-sensitive optical coherence tomography (PS-OCT) capable of providing polarization contrasts such as phase retardation and degree of polarization uniformity (DOPU) was used for visualizing human meibomian glands (MGs) and investigating morphological characteristics of them. Especially, with the help of the DOPU contrast, MGs were exclusively extracted from the volumetric OCT image. In vivo PS-OCT measurements were performed on the upper eyelids of different age groups. From these measurements, different age-dependent aspects of the MG structure were also observed. Based on these observations, it can be inferred that the PS-OCT system has the potential for clinical diagnosis and investigation of MG-related dry eye diseases like MG dysfunction (MGD) and acinar atrophy.
authors.affiliation: University of British Columbia, Department of Electrical and Computer Engineering, 2332 Main Mall, Vancouver, BC, V6T 1Z4, CanadabUniversity of Tsukuba, Institute of Applied Physics, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8573, Japan.
authors.forename: Myeong Jin
authors.initials: MJ
authors.lastname: Ju
authors.affiliation: Gwangju Institute of Science and Technology, School of Information and Communication, 123 Cheomdan-gwagiro, Gwangju 500-712, Republic of Korea.
authors.forename: Jun Geun
authors.initials: JG
authors.lastname: Shin
authors.affiliation: University of Tsukuba, Institute of Applied Physics, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8573, JapandUniversity of Tsukuba, Faculty of Medicine, Department of Ophthalmology, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Sujin
authors.initials: S
authors.lastname: Hoshi
authors.affiliation: University of Tsukuba, Institute of Applied Physics, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8573, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yasuno
authors.affiliation: Gwangju Institute of Science and Technology, School of Information and Communication, 123 Cheomdan-gwagiro, Gwangju 500-712, Republic of Korea.
authors.forename: Byeong Ha
authors.initials: BH
authors.lastname: Lee
authors.affiliation: University of British Columbia, Department of Electrical and Computer Engineering, 2332 Main Mall, Vancouver, BC, V6T 1Z4, Canada.
authors.forename: Shuo
authors.initials: S
authors.lastname: Tang
authors.affiliation: Gwangju Institute of Science and Technology, Advanced Photonic Research Institute, 123 Cheomdan-gwagiro, Gwangju 500-712, Republic of Korea.
authors.forename: Tae Joong
authors.initials: TJ
authors.lastname: Eom
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008537:Meibomian Glands / Q000033:anatomy & histology* / Q000502:physiology*; D008875:Middle Aged; D041623:Tomography, Optical Coherence / Q000379:methods*