title: Tandem ruthenium-catalyzed transfer-hydrogenative cyclization/intramolecular Diels-Alder reaction of enediynes affording dihydrocoumarin-fused polycycles.
abstract: A tandem transfer-hydrogenative cyclization/intramolecular Diels-Alder reaction of enediyne substrates, containing 1,6-diyne, acrylate dienophile, and phenol tether moieties, was successfully accomplished using the combination of a cationic ruthenium complex, [CpRu(AN)3]PF6 (1b, Cp = η(5)-C5H5, AN = MeCN), as the catalyst and a Hantzsch ester as the H2 surrogate to afford interesting dihydrocoumarin-fused polycyclic products as single diastereomers.
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University , Chikusa, Nagoya 464-8601, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Kazuma
authors.initials: K
authors.lastname: Matsui
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Shibuya
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D061565:Cycloaddition Reaction; D053281:Enediynes / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000480:Alkynes; D003374:Coumarins; D053281:Enediynes; D006576:Heterocyclic Compounds, 4 or More Rings; D007659:Ketones; D012428:Ruthenium