title: Direct borylation of primary C-H bonds in functionalized molecules by palladium catalysis.
abstract: Organoborane compounds are among the most commonly employed intermediates in organic synthesis and serve as crucial precursors to alcohols, amines, and various functionalized molecules. A simple palladium-based system catalyzes the conversion of primary C(sp(3) )H bonds in functionalized complex organic molecules into alkyl boronate esters. Amino acids, amino alcohols, alkyl amines, and a series of bioactive molecules can be functionalized with the use of readily available and removable directing groups in the presence of commercially available additives, simple ligands, and oxygen (O2 ) as the terminal oxidant. This approach represents an economic and environmentally friendly method that could find broad applications.
authors.affiliation: Beijing National Laboratory of Molecule Science (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Green Chemistry Center, Peking University, Beijing, 100871 (China).
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Zhang
authors.forename: Guihua
authors.initials: G
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Guo
authors.forename: Xi-Sha
authors.initials: XS
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Pan
authors.forename: Kang
authors.initials: K
authors.lastname: Chen
authors.forename: Zhang-Jie
authors.initials: ZJ
authors.lastname: Shi
keywords: CH functionalization; amino acids; borylation; directing groups; palladium