title: Indole and trans-chalcone attenuate amyloid β plaque accumulation in male Wistar rat: in vivo effectiveness of two anti-amyloid scaffolds.
abstract: Alzheimer's disease (AD) is an irreversible neurodegenerative condition in which abnormal accumulation of amyloid plaques is observed, and for which no effective treatment still exist. In recent years, many aromatic small molecules have been observed to have anti-amyloid effect, and may have the potential to attenuate AD symptoms. The indole core and the flavonoid precursor trans-chalcone have been studied here as representative of these group of molecules. Formation of amyloid plaques has been induced in a rat model of AD, after what the two compounds were given to experimental groups. Shuttle box experiment and histological examination of brain amyloid plaques was then performed in order to test the effect of 28 days treatment on rats memory and brain tissue integrity. In conclusion, it was found that both compounds were effective in ameliorating the rats condition, and could be considered as interesting potential drug candidates.
authors.forename: Parichehreh
authors.initials: P
authors.lastname: Yaghmaei
authors.forename: Raheleh
authors.initials: R
authors.lastname: Kheirbakhsh
authors.forename: Mehrooz
authors.initials: M
authors.lastname: Dezfulian
authors.forename: Ali
authors.initials: A
authors.lastname: Haeri-Rohani
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.affiliation: Biosensor Research Center, Endocrinology and Metabolism Molecular- Cellular Sciences Institute, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Avenue, 1411413137 Tehran, Iran - Email: aehabibi@sina.tums.ac.ir, azadehabibi@yahoo.fr.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Ebrahim-Habibi
mesh_terms: D016229:Amyloid beta-Peptides / Q000633:toxicity; D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001362:Avoidance Learning / Q000187:drug effects; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000378:metabolism; D002599:Chalcone / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005625:Frontal Lobe / Q000187:drug effects / Q000473:pathology; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D010446:Peptide Fragments / Q000633:toxicity; D058225:Plaque, Amyloid / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D016229:Amyloid beta-Peptides; D014150:Antipsychotic Agents; D007211:Indoles; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D002599:Chalcone; C030374:indole