title: Steroidal glycosides from the underground parts of Yucca glauca and their cytotoxic activities.
abstract: Six steroidal glycosides and 14 known compounds were isolated from the underground parts of Yucca glauca (Agavaceae). Their structures were determined from extensive spectroscopic analysis, including analysis of two-dimensional NMR data, and from chemical transformations. The compounds were also evaluated for cytotoxic activities against HL-60 human leukemia cells and A549 human lung adenocarcinoma cells. Four spirostanol glycosides and three furostanol glycosides exhibited cytotoxic activities against both HL-60 and A549 cells. Two of the compounds induced apoptosis in HL-60 cells.
authors.affiliation: Department of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, 1432-1, Horinouchi, Hachiouji, Tokyo 192-0392, Japan. Electronic address: yokosuka@toyaku.ac.jp.
authors.forename: Akihito
authors.initials: A
authors.lastname: Yokosuka
authors.affiliation: Department of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, 1432-1, Horinouchi, Hachiouji, Tokyo 192-0392, Japan.
authors.forename: Tomoka
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Department of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, 1432-1, Horinouchi, Hachiouji, Tokyo 192-0392, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Tatsuno
authors.affiliation: Department of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, 1432-1, Horinouchi, Hachiouji, Tokyo 192-0392, Japan. Electronic address: mimakiy@toyaku.ac.jp.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Mimaki
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D018514:Plant Structures / Q000737:chemistry; D013256:Steroids / Q000302:isolation & purification / Q000494:pharmacology*; D027623:Yucca / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D013256:Steroids
keywords: A549 cells; Agavaceae; Apoptosis; Furostanol glycosides; HL-60 cells; Soapweed; Spirostanol glycosides; Steroidal glycosides; Yucca glauca