title: Pre-procedural antibiotics for endoscopic urological procedures: Initial experience in individuals with spinal cord injury and asymptomatic bacteriuria.
abstract: OBJECTIVE
  The objective of this study was to compare the safety, efficacy, quality-of-life impact, and costs of a single dose or a longer course of pre-procedural antibiotics prior to elective endoscopic urological procedures in individuals with spinal cord injury and disorders (SCI/D) and asymptomatic bacteriuria.
  
  
  METHODS
  A prospective observational study.
  
  
  METHODS
  Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia, USA.
  
  
  METHODS
  Sixty persons with SCI/D and asymptomatic bacteriuria scheduled to undergo elective endoscopic urological procedures.
  
  
  METHODS
  A single pre-procedural dose of antibiotics vs. a 3-5-day course of pre-procedural antibiotics.
  
  
  METHODS
  Objective and subjective measures of health, costs, and quality of life.
  
  
  RESULTS
  There were no significant differences in vital signs, leukocytosis, adverse events, and overall satisfaction in individuals who received short-course vs. long-course antibiotics. There was a significant decrease in antibiotic cost (33.1 ± 47.6 vs. 3.6 ± 6.1 US$, P = 0.01) for individuals in the short-course group. In addition, there was greater pre-procedural anxiety (18 vs. 0%, P < 0.05) for individuals who received long-course antibiotics.
  
  
  CONCLUSIONS
  SCI/D individuals with asymptomatic bacteriuria may be able to safely undergo most endoscopic urological procedures with a single dose of pre-procedural antibiotics. However, further research is required and even appropriate pre-procedural antibiotics may not prevent severe infections.
authors.forename: Julio T
authors.initials: JT
authors.lastname: Chong
authors.forename: Adam P
authors.initials: AP
authors.lastname: Klausner
authors.forename: Albert
authors.initials: A
authors.lastname: Petrossian
authors.forename: Michael D
authors.initials: MD
authors.lastname: Byrne
authors.forename: Jewel R
authors.initials: JR
authors.lastname: Moore
authors.forename: Lance L
authors.initials: LL
authors.lastname: Goetz
authors.forename: David R
authors.initials: DR
authors.lastname: Gater
authors.forename: B Mayer
authors.initials: BM
authors.lastname: Grob
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D001437:Bacteriuria / Q000517:prevention & control*; D003558:Cystoscopy / Q000009:adverse effects / Q000379:methods* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011300:Preoperative Care; D013119:Spinal Cord Injuries / Q000150:complications*; D001750:Urinary Bladder, Neurogenic / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotic prophylaxis; Bacteriuria; Neurogenic bladder; Spinal cord injury; Urological surgical procedures