title: Dual sensor for Cd(II) and Ca(II): selective nanoliter-scale sensing of metal ions.
abstract: The first selective, dual sensor for Ca(2+) and Cd(2+) capable of detection at 100 pM concentrations was designed and synthesized. The experimental observations made for the MC-cation complexes and the selectivity of compounds 1 and 2 with Ca(2+) and Cd(2+) ions were further explored using density functional theory. A first step toward a nanoliter-scale dip sensor for the dual sensing of Ca(2+) and Cd(2+) was demonstrated using microstructured optical fiber as the sensing platform which is important for ion sensing in confined spaces such as the medium surrounding cell clusters. In addition, this system displays picomolar sensitivity for these ions, with an added ability to reproducibly turn ion-binding on/off.
authors.affiliation: ARC Centre of Excellence for Nanoscale BioPhotonics, Institute of Photonics & Advanced Sensing and School of Chemistry & Physics, The University of Adelaide , South Australia, Australia 5005.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Heng
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Mak
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Stubing
authors.forename: Tanya M
authors.initials: TM
authors.lastname: Monro
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Abell
mesh_terms: D002104:Cadmium / Q000032:analysis*; D002118:Calcium / Q000032:analysis*; D057230:Limit of Detection; D036103:Nanotechnology; D055100:Optical Fibers
chemical_list: D002104:Cadmium; D002118:Calcium