title: The correlation of serum levels of leptin, leptin receptor and NO x (NO 2 (-) and NO 3 (-)) in patients with obstructive sleep apnea syndrome.
abstract: The aim of this study was to investigate the relations between nitric oxide (NO) and leptin levels in a cohort of untreated adult Obstructive sleep apnea syndrome (OSAS) patients. Between June 1, 2012, and January 1, 2013, we evaluated a total of 58 subjects including 36 OSAS patients and 22 healthy controls, both polysomnographically confirmed. Following the completion of polysomnographic evaluation, serum samples were taken at 08:00. Leptin, leptin receptor, NO2 (-) and NO3 (-) levels were analyzed by commercial ELISA kits. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) version 16.0 (SPSS Inc., Chicago, IL, USA). There was no statistically significant difference between the OSAS patients and control groups with relation to the demographic parameters and body mass index (p > 0.05). Significantly higher serum leptin and plasma NO levels were found in OSAS patients compared to the controls (p < 0.001). In this study, higher leptin levels which were positively correlated with NO levels in OSAS group may indicate a possible link with increased incidence of airway pathologies in these patients.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Bozok University Medical Faculty, Adnan Menderes Bulvarı No: 42, Yozgat, Turkey, drzeliha19@hotmail.com.
authors.forename: Zeliha
authors.initials: Z
authors.lastname: Kapusuz Gencer
authors.forename: Mahmut
authors.initials: M
authors.lastname: Özkiriş
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Göçmen
authors.forename: Yavuz Selim
authors.initials: YS
authors.lastname: Intepe
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Akin
authors.forename: Namık
authors.initials: N
authors.lastname: Delibaş
authors.forename: Namık
authors.initials: N
authors.lastname: Delibaşi
authors.forename: Levent
authors.initials: L
authors.lastname: Saydam
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood*; D009573:Nitrites / Q000097:blood*; D009765:Obesity / Q000150:complications; D017286:Polysomnography; D011446:Prospective Studies; D054411:Receptors, Leptin / Q000097:blood*; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications; D055815:Young Adult
chemical_list: D020738:Leptin; D009566:Nitrates; D009573:Nitrites; D054411:Receptors, Leptin; D009569:Nitric Oxide