title: Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp3)-H bonds with aryl halides.
abstract: In this work, we have disclosed the nickel-catalyzed unactivated β-C(sp(3))-H bond arylation of aliphatic acid derivatives with aryl iodides/bromides via bidentate chelation-assistance of an 8-aminoquinoline moiety. These preliminary results indicate the intrinsic catalytic potential of nickel metal for unactivated C(sp(3))-H bond arylation.
authors.affiliation: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China. jsyou@scu.edu.cn.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Li
authors.forename: Jiaxing
authors.initials: J
authors.lastname: Dong
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Huang
authors.forename: Kaizhi
authors.initials: K
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Wu
authors.forename: Feijie
authors.initials: F
authors.lastname: Song
authors.forename: Jingsong
authors.initials: J
authors.lastname: You
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry; D002384:Catalysis; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*
chemical_list: D000634:Aminoquinolines; D002614:Chelating Agents; D005227:Fatty Acids; D006842:Hydrocarbons, Brominated; D006847:Hydrocarbons, Iodinated; D009532:Nickel; C080436:8-aminoquinoline