title: Boswellia serrata has beneficial anti-inflammatory and antioxidant properties in a model of experimental colitis.
abstract: Ulcerative colitis is an inflammatory disease that involves only the colon and rectum, being characterized by leukocyte infiltrate and superficial ulcers in the intestinal mucosa. To evaluate the anti-inflammatory and antioxidant effects of extract from the Boswellia serrata plant in an experimental rat model of acute ulcerative colitis induced by the administration of acetic acid (AA). An extract of B. serrata (34.2 mg/kg/day) was administered by oral gavage for 2 days before and after the induction of colitis with 4 mL of 4% AA. The anal sphincter pressure in the colitis group showed a significant decrease compared to that of the control groups (p < 0.001). The analysis of the values of lipid peroxidation (LPO) obtained by substances that react with thiobarbituric acid (TBARS) showed a significantly increased LPO in the colitis group compared to the control groups (p < 0.001). The nitric oxide levels and the expression of inducible nitric oxide synthase (iNOS) showed a significant increase in the colitis group compared to control groups (p < 0.01). Both pretreatment and treatment with B. serrata exhibited significantly reduced lipid peroxidation, nitric oxide and iNOS and showed improvements in tissue injury and anal sphincter pressure in animals with ulcerative colitis. The B. serrata extract has protective anti-inflammatory and antioxidant effects that inhibit inflammatory mediators in acute experimental colitis.
authors.affiliation: Universidade Federal do Rio Grande do Sul-UFRGS, Programa de Pós-Graduação em Medicina: Ciências Médicas, Brasil; Hospital de Clínicas de Porto Alegre-HCPA, Laboratório de Hepatologia e Gastroenterologia Experimental, Brasil.
authors.forename: Renata Minuzzo
authors.initials: RM
authors.lastname: Hartmann
authors.forename: Henrique Sarubbi
authors.initials: HS
authors.lastname: Fillmann
authors.forename: Maria Isabel Morgan
authors.initials: MI
authors.lastname: Martins
authors.forename: Luise
authors.initials: L
authors.lastname: Meurer
authors.forename: Norma Possa
authors.initials: NP
authors.lastname: Marroni
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D029743:Boswellia / Q000737:chemistry*; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000188:drug therapy*; D003106:Colon / Q000473:pathology; D004195:Disease Models, Animal; D015227:Lipid Peroxidation; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat
keywords: Boswellia serrata; inflammation; nitric oxide; oxidative stress; ulcerative colitis