title: Auditory sensory processing deficits in sensory gating and mismatch negativity-like responses in the social isolation rat model of schizophrenia.
abstract: Patients with schizophrenia exhibit disturbances in information processing. These disturbances can be investigated with different paradigms of auditory event related potentials (ERP), such as sensory gating in a double click paradigm (P50 suppression) and the mismatch negativity (MMN) component in an auditory oddball paradigm. The aim of the current study was to test if rats subjected to social isolation, which is believed to induce some changes that mimic features of schizophrenia, displays alterations in sensory gating and MMN-like response. Male Lister-Hooded rats were separated into two groups; one group socially isolated (SI) for 8 weeks and one group housed (GH). Both groups were then tested in a double click sensory gating paradigm and an auditory oddball paradigm (MMN-like) paradigm. It was observed that the SI animals showed reduced sensory gating of the cortical N1 amplitude. Furthermore, the SI animals showed significant reduction in cortical MMN-like response compared with the GH animals. No deficits in sensory gating or MMN-like response were observed in the hippocampus (CA3) of the SI animals compared with GH animals. In conclusion, the change in sensory gating of the N1 amplitude supports previous findings in SI rats and the reduced MMN-like response is similar to the deficits of MMN seen in patients with schizophrenia. Since reduced auditory MMN amplitude is believed to be more selectively associated with schizophrenia than other measures of sensory gating deficits, the current study supports the face validity of the SI reared rat model for schizophrenia.
authors.affiliation: Synaptic Transmission 1, H. Lundbeck A/S, Otilliavej 7-9, DK-2500 Valby, Denmark; Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen University Hospital, Psychiatric Center Glostrup, Glostrup, Denmark. Electronic address: low@lundbeck.com.
authors.forename: Louise
authors.initials: L
authors.lastname: Witten
authors.affiliation: Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen University Hospital, Psychiatric Center Glostrup, Glostrup, Denmark; NICHE, Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
authors.forename: Bob
authors.initials: B
authors.lastname: Oranje
authors.affiliation: Synaptic Transmission 1, H. Lundbeck A/S, Otilliavej 7-9, DK-2500 Valby, Denmark.
authors.forename: Arne
authors.initials: A
authors.lastname: Mørk
authors.affiliation: Medical Affairs-Addiction Disorders, H. Lundbeck A/S, Otilliavej 7-9, DK-2500 Valby, Denmark.
authors.forename: Björn
authors.initials: B
authors.lastname: Steiniger-Brach
authors.affiliation: Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen University Hospital, Psychiatric Center Glostrup, Glostrup, Denmark.
authors.forename: Birte Y
authors.initials: BY
authors.lastname: Glenthøj
authors.affiliation: Synaptic Transmission 1, H. Lundbeck A/S, Otilliavej 7-9, DK-2500 Valby, Denmark.
authors.forename: Jesper Frank
authors.initials: JF
authors.lastname: Bastlund
mesh_terms: D000161:Acoustic Stimulation; D000704:Analysis of Variance; D000818:Animals; D003265:Contingent Negative Variation / Q000502:physiology*; D004195:Disease Models, Animal; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D008297:Male; D009043:Motor Activity; D051381:Rats; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D055139:Sensory Gating / Q000502:physiology*; D012934:Social Isolation / Q000523:psychology*
keywords: Auditory gating; Mismatch negativity; Schizophrenia; Sensory gating; Social isolation