title: [Immediate thyrotropic effects of mineral water Naftussya their autonomic relevence and possibility to forecast].
abstract: Clinical physiological monitoring of 32 men aged 25-60 years with chronic stoneless cholecystitis in the phase of remission found that in 14 patients 75-85 minutes after drinking the bioactive water Naftussya (3 ml/kg, t(0) 18-20 degrees C) the plasma level of total triiodothyronine (T3) was not significantly changed, while in 9 patients it was reduced to 0.26 +/- 0.10 nM/1 (by 11%). In the other 9 patients the level increased to 0.29 +/- 0,04 nM/1 (by 17%). The changes in T3 level correlated negatively with the changes in absolute (r = -0.55) and relative (r = -0.47) power spectral density (PSD) of ultra very low-frequency components of heart rate variability (HRV). These changes correlated positively (r = 0.46) with the changes in relative PSD of low-frequency components of HRV. Subject to a weak correlation with HRV parameter pNN50 (r = -0.21) canonical correlation coefficient (R) between changes in HRV parameters and T3 reaches 0.68 (p = 0.002). On the other hand, the changes in T3 correlated with its initial level (r = -0.46), as well as initial levels of moda (r = -0.40), its amplitude (r = 0.30) and absolute PSD of low-frequency components HRV (r = -0.33), i.e. thyrotropic effects conditionized these parameters by 30% (R = 0.55; p = 0.038). The method ofdiscriminant analysis has identified 14 primary parameters that allowed predicting the thyrotropic effect of Naftussya water with 100% accuracy.
authors.forename: N V
authors.initials: NV
authors.lastname: Koziavkina
authors.forename: L H
authors.initials: LH
authors.lastname: Baryliak
authors.forename: O R
authors.initials: OR
authors.lastname: Ianchiĭ
authors.forename: O L
authors.initials: OL
authors.lastname: Fuchko
mesh_terms: D042101:Acalculous Cholecystitis / Q000628:therapy; D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D001452:Balneology / Q000379:methods*; D016002:Discriminant Analysis; D006294:Health Resorts; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D008900:Mineral Waters / Q000008:administration & dosage / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D013961:Thyroid Gland / Q000294:innervation / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D008900:Mineral Waters; D014284:Triiodothyronine