title: Nonhuman primate and human challenge models of pertussis.
abstract: Despite pertussis vaccination rates in excess of 95%, pertussis rates in the United States have been rising over the last 30 years, with increasingly larger outbreaks in 2004, 2010, and 2012. The reasons for this resurgence of pertussis are not clearly understood. The recent development of a baboon model of pertussis, along with the future development of a human challenge model of pertussis, has the potential to provide a path forward for answering critical questions about pertussis pathogenesis and host responses and will likely aid in the development of next-generation pertussis vaccines.
authors.affiliation: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland.
authors.forename: Tod J
authors.initials: TJ
authors.lastname: Merkel
authors.forename: Scott A
authors.initials: SA
authors.lastname: Halperin
mesh_terms: D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology*; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000517:prevention & control; D004195:Disease Models, Animal; D006801:Humans; D010215:Papio; D010567:Pertussis Vaccine / Q000276:immunology*; D011323:Primates; D014481:United States / Q000453:epidemiology; D014917:Whooping Cough / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control*
chemical_list: D010567:Pertussis Vaccine
keywords: Animal models; Bacterial vaccines; Pertussis; Pulmonary infections