title: Transcatheter neoaortic valve replacement utilizing the Melody Valve in hypoplastic left heart syndrome.
abstract: Percutaneous transcatheter pulmonary valve replacement with the Melody Valve is fast becoming an important adjunct in the treatment of older children and adults with failing right ventricular outflow tract conduits. Recently, the Melody Valve has also been successfully implanted in the tricuspid, mitral, and aortic positions, typically within a failing bioprosthetic valve. We present a patient who underwent Fontan palliation for hypoplastic left heart syndrome variant and subsequently developed severe neoaortic regurgitation, which was successfully treated with a transcatheter neoaortic valve replacement. To our knowledge, this is the first successful use of the Melody Valve in the neoaortic position in a patient with single-ventricle physiology. Successful relief of neoaortic valve regurgitation using replacement with a transcatheter valve may allow avoidance of additional surgery, increase functional longevity of single-ventricle palliation, and postpone the need for orthotopic heart transplantation.
authors.affiliation: Department of Pediatric Cardiology, University of Utah at Primary Children's Medical Center, Salt Lake City, Utah.
authors.forename: Mary Hunt
authors.initials: MH
authors.lastname: Martin
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Gruber
authors.forename: Robert G
authors.initials: RG
authors.lastname: Gray
mesh_terms: D001021:Aortic Valve / Q000503:physiopathology / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D006328:Cardiac Catheterization / Q000295:instrumentation* / Q000379:methods; D002648:Child; D018618:Echocardiography, Doppler, Color; D005260:Female; D018729:Fontan Procedure / Q000009:adverse effects*; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D010166:Palliative Care; D011474:Prosthesis Design; D016896:Treatment Outcome
keywords: congenital heart disease; pediatric intervention; valve disease