title: Nocturnal enuresis in sickle cell disease.
abstract: Nocturnal enuresis is a prevalent and challenging problem in children and young adults with sickle cell disease (SCD). Limited progress has been made in elucidating etiology and pathophysiology of nocturnal enuresis in individuals with SCD. Among adults with SCD ages 18-20 years, approximately 9% report nocturnal enuresis. Nocturnal enuresis contributes to decreased health related quality of life in people with SCD, resulting in low self-esteem and sometimes social isolation. Postulated non-mutually exclusive causes of nocturnal enuresis in individuals with SCD include hyposthenuria leading to nocturnal polyuria, decreased bladder capacity or nocturnal bladder overactivity, increased arousal thresholds, and sleep disordered breathing. No evidence-based therapy for nocturnal enuresis in SCD exists. This review is focused on describing the natural history, postulated causes and a rational approach to the evaluation and management of nocturnal enuresis in children and adults with SCD.
authors.affiliation: Vanderbilt Medical Scholars Program, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Rachel B
authors.initials: RB
authors.lastname: Wolf
authors.forename: Adetola A
authors.initials: AA
authors.lastname: Kassim
authors.forename: Robert L
authors.initials: RL
authors.lastname: Goodpaster
authors.forename: Michael R
authors.initials: MR
authors.lastname: DeBaun
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications* / Q000601:surgery; D050034:Antidiuretic Agents / Q000627:therapeutic use; D001921:Brain / Q000254:growth & development / Q000473:pathology; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D006801:Humans; D053206:Nocturnal Enuresis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D011788:Quality of Life; D012891:Sleep Apnea Syndromes / Q000209:etiology; D001743:Urinary Bladder / Q000502:physiology
chemical_list: D050034:Antidiuretic Agents; D018680:Cholinergic Antagonists; D003894:Deamino Arginine Vasopressin