title: Cell-based delivery of brain-derived neurotrophic factor in experimental allergic encephalomyelitis.
abstract: Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine with neuroprotective properties that has been identified as a potential therapeutic agent for diseases of the central nervous system (CNS). The use of BDNF has been limited by a short serum half-life and poor penetration of the blood-brain barrier. To address this limitation we have explored cell-based approaches to delivery. We have used experimental allergic encephalomyelitis (EAE), an inflammatory disease of the CNS, as a model system. We engineered hematopoietic stem cells to produce BDNF to determine the feasibility and effectiveness of cell-based delivery of BDNF into the CNS in EAE. We review those studies here.
authors.affiliation: 1 Multiple Sclerosis Center of Excellence-East , Department of Veterans Affairs Maryland Health Care System, Baltimore, Maryland.
authors.forename: Tapas K
authors.initials: TK
authors.lastname: Makar
authors.forename: Vamshi K C
authors.initials: VK
authors.lastname: Nimmagadda
authors.forename: David
authors.initials: D
authors.lastname: Trisler
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Bever
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D002465:Cell Movement; D002478:Cells, Cultured; D002490:Central Nervous System / Q000187:drug effects*; D016207:Cytokines / Q000378:metabolism; D016503:Drug Delivery Systems; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000628:therapy*; D005818:Genetic Engineering; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D019076:Transgenes / Q000235:genetics; D015854:Up-Regulation
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D018696:Neuroprotective Agents