title: Influence of hypoxia in bronchial response to bronchoconstrictor substances at newborn with distress respiratory syndrome (DRS).
abstract: OBJECTIVE
  In this work, role of hypoxia in respiratory system on live and exited newborns weight 250-3000g.) which have died due to different reasons is studied.
  
  
  METHODS
  Response of tracheal rings in acetylcholine and histamine in different molar concentrations (10(-4), 10(-3), 10(-2), 10(-1) mol/dm3) was monitored. Study of the tracheal smooth musculature (TSM) tonus was performed in 12 tracheal preparations obtained from the newborns exited due to different reasons.
  
  
  RESULTS
  Based on the functional analysis of the isolated tracheal preparations, we have concluded that the cases born with lung atelectasis have caused significant response ofTSM to Acetylcholine and Histamine (p > 0.01). In cases of control group, which has exited due to different reasons from lung inflammatory processes (e.g.: pneumonia, bronchopneumonia, cerebral hemorrhage), Acetylcholine and Histamine have also caused significant constriction of tracheal smooth musculature.
  
  
  CONCLUSIONS
  Results suggest that exited cases with lung atelectasis (hypoxemia) and cases of lung inflammatory processes have significant constrictor action to Acetylcholine and Histamine in tracheobronchial system.
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Prishtina, Clinical Centre, Prishtina, Kosova.
authors.forename: Adnan
authors.initials: A
authors.lastname: Bozalija
authors.affiliation: Smartmed, St. Rexhep Krasniqi, EXDC, Prishtina, Kosova.
authors.forename: Pëllumb
authors.initials: P
authors.lastname: Islami
authors.affiliation: Department of Pediatric, Faculty of Medicine, University of Prishtina, Clinical Centre, Prishtina, Kosova.
authors.forename: Njazi
authors.initials: N
authors.lastname: Gashi
authors.affiliation: Department of Surgery, Faculty of Medicine, University of Prishtina, Clinical Centre, Prishtina, Kosova.
authors.forename: Halit
authors.initials: H
authors.lastname: Maloku
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Prishtina, Clinical Centre, Prishtina, Kosova.
authors.forename: Ragip
authors.initials: R
authors.lastname: Shabani
authors.affiliation: Department of Clinical Anatomy, Faculty of Medicine, University of Prishtina, Clinical Centre, Prishtina, Kosova.
authors.forename: Sadi
authors.initials: S
authors.lastname: Bexheti
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre, Prishtina, Kosova.
authors.forename: Hilmi
authors.initials: H
authors.lastname: Islami
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D016084:Bronchoconstriction; D016022:Case-Control Studies; D018679:Cholinergic Agonists / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D017442:Histamine Agonists / Q000494:pharmacology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D007231:Infant, Newborn; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000187:drug effects*; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology*; D014132:Trachea / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D018679:Cholinergic Agonists; D017442:Histamine Agonists; D006632:Histamine; D000109:Acetylcholine