title: Novel benzoxazoles: synthesis and antibacterial, antifungal, and antitubercular activity against antibiotic-resistant and -sensitive microbes.
abstract: A new series of 5-(p-substituted benzamido/phenylacetamido)-2-(p-tert-butylphenyl)benzoxazole derivatives were synthesized and evaluated for their antibacterial, antifungal, and antimycobacterial activities against antibiotic-resistant and -sensitive Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and Mycobacterium tuberculosis as well as against Candida albicans and Candida krusei. The compounds possessed broad-spectrum activity against all of the tested Gram-positive and Gram-negative bacteria and yeasts, their minimum inhibitory concentrations (MICs) ranging between 16-128 microg/ml. One compound exhibited significant antibacterial activity (16 microg/ml) against an antibiotic-resistant Enterococcus faecalis isolate, having twice the potency of the compared standard drugs vancomycin and gentamycin sulfate. The compounds also showed moderate antitubercular activity with MIC values between 8-128 microg/ml against Mycobacterium tuberculosis and its clinical isolate.
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Tandogan, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Arisoy
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Tandogan, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Temiz-Arpaci
authors.affiliation: Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 06330 Etiler, Ankara, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Kaynak-Onurdag
authors.affiliation: Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 06330 Etiler, Ankara, Turkey.
authors.forename: Selda
authors.initials: S
authors.lastname: Ozgen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D001583:Benzoxazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000995:Antitubercular Agents; D001583:Benzoxazoles