title: [A dye densitometry analysis method for noninvasive measurement of cardiac output based on NIRS].
abstract: Currently, there exist technology problems in cardiac output (CO) parameter detection clinically, such as invasive and complex operation, as well as possibility of infection and death for patients. In order to solve these problems, a noninvasive and continuous method based on NIRS for CO detection was presented. In this way, the concentration changing of indocyanine green (ICG) dye in the patient's arterial blood was dynamically measured and analyzed, so that the CO could be noninvasively and continuously measured according to the characteristic parameters of dye densitometry curve. While the ICG dye was injected into the patient's body by the median cubital vein, block of photoelectric pulse dye densitometry measurement system as the lower machine acquired pulse wave data and uploaded the data to upper computer. In the scheme, two specialized light sources of LED at 940 and 805 nm were used to capture the signals of sufferer's fingertip pulse wave synchronously and successively. The CO value could then be successfully calculated through drawing complete ICG concentration variation of dye dilution and excretion process and computing mean transmission time (MTT) by upper computer. Compared with the "gold standard" method of thermodilution, the maximum relative error of this method was below 9. 76%, and the mean relative error was below 4. 39%. The result indicates that the method can be used as a kind of convenient operation, noninvasive and continuous solution for clinical CO measurement.
authors.affiliation: College of Instrumentation and Electrical Engineering, Jilin University Changchun, China. mmlu11@mails.jlu.edu.cn
authors.forename: Meng-Meng
authors.initials: MM
authors.lastname: Lu
authors.affiliation: State Key Laboratory of Laser Interaction with Matter, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.
authors.forename: Hong-Xuan
authors.initials: HX
authors.lastname: Wang
authors.affiliation: College of Instrumentation and Electrical Engineering, Jilin University Changchun, China.
authors.forename: Guang-Da
authors.initials: GD
authors.lastname: Liu
authors.affiliation: First Hospital, Jilin University, Changchun 130021, China.
authors.forename: Gui-Jie
authors.initials: GJ
authors.lastname: Xin
authors.affiliation: College of Instrumentation and Electrical Engineering, Jilin University Changchun, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yu
authors.affiliation: College of Instrumentation and Electrical Engineering, Jilin University Changchun, China.
authors.forename: Yu-Tong
authors.initials: YT
authors.lastname: Zha
mesh_terms: D002302:Cardiac Output; D003720:Densitometry; D004395:Dye Dilution Technique; D005385:Fingers; D006801:Humans; D007208:Indocyanine Green
chemical_list: D007208:Indocyanine Green