title: Relaxin inhibit cardiac fibrosis induced by phorbol 12-myristate 13-acetate.
abstract: Relaxin is known to inhibit cardiac fibrosis. However, it is unclear whether relaxin could regulate the effects of Phorbol 12-myristate 13-acetate (PMA, PKC activator) on cardiac fibrosis. So the influence of relaxin on the cell proliferation and collagen expression induced by PMA in cultured cardiac fibroblasts was studied. It showed that PMA significantly increased cardiac fibroblasts proliferation, Type I pro-collagen protein expression, Type I pro-collagen mRNA expression, and rhRLX absolutely significantly decreased PMA induced effects on cardiac fibroblasts proliferation and Type I pro-collagen expressions, indicating that relaxin could inhibit cardiac fibrosis induced by PMA.
authors.affiliation: Health and Heart Center, the Beijing Friendship Hospital affiliated the Capital Medical University, Beijing 100050, China.
authors.forename: Yu Peng
authors.initials: YP
authors.lastname: Wang
authors.affiliation: Cardiovascular Center, the Beijing Friendship Hospital affiliated the Capital Medical University, Beijing 100050, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: Cardiovascular Center, the Beijing Friendship Hospital affiliated the Capital Medical University, Beijing 100050, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.affiliation: Cardiovascular Center, the Beijing Friendship Hospital affiliated the Capital Medical University, Beijing 100050, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Cardiovascular Center, the Beijing Friendship Hospital affiliated the Capital Medical University, Beijing 100050, China.
authors.forename: Yong Quan
authors.initials: YQ
authors.lastname: Wu
authors.affiliation: Cardiovascular Center, the Beijing Friendship Hospital affiliated the Capital Medical University, Beijing 100050, China.
authors.forename: Hong Wei
authors.initials: HW
authors.lastname: Li
authors.affiliation: Health and Heart Center, the Beijing Friendship Hospital affiliated the Capital Medical University, Beijing 100050, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D005347:Fibroblasts / Q000473:pathology; D005355:Fibrosis; D006331:Heart Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012065:Relaxin / Q000627:therapeutic use*; D013755:Tetradecanoylphorbol Acetate / Q000031:analogs & derivatives
chemical_list: C016658:phorbolol myristate acetate; D012065:Relaxin; D013755:Tetradecanoylphorbol Acetate