title: Association between the metabolic syndrome and high tumor grade and stage of primary urothelial cell carcinoma of the bladder.
abstract: OBJECTIVE
  To compare histopathologic findings of patients who underwent transurethral resection of a bladder tumor (TUR-B) between groups with and without the metabolic syndrome.
  
  
  METHODS
  We retrospectively analyzed data of 535 patients who underwent TUR-B in our department between October 2005 and March 2011. All patients had primary urethelial cell carcinoma (UCB). Histologic stage, grade, the presence of hypertension, diabetes mellitus, body mass index (BMI), waist circumference, HDL and trigliseride levels were evaluated. The TNM classification was used, with Ta tumor accepted as lower stage and T1 and T2 tumors as higher stage bladder cancers. Also, the pathological grading adopted by the 2004 World Health Organization grading system were applied. Non-invasive papillary urothelial neoplasms of low malignant potential were regarded as low grade.
  
  
  RESULTS
  Among the total of 509 patients analyzed in our study, there were 439 males (86.2%) and 70 females (13.8%). Metabolic syndrome was significantly associated with high histologic grade, and high pathologic stage (p<0.001).
  
  
  CONCLUSIONS
  The patients with metabolic syndrome were found to have statistically significant higher T stage and grade of bladder cancer. Further studies with more patients are needed to confirm our study.
authors.affiliation: Okmeydani Training and Research Hospital Department of Urology, Istanbul, Turkey E-mail : mrt_drsn@hotmail.com.
authors.forename: Emin
authors.initials: E
authors.lastname: Ozbek
authors.forename: Alper
authors.initials: A
authors.lastname: Otunctemur
authors.forename: Murat
authors.initials: M
authors.lastname: Dursun
authors.forename: Ismail
authors.initials: I
authors.lastname: Koklu
authors.forename: Suleyman
authors.initials: S
authors.lastname: Sahin
authors.forename: Huseyin
authors.initials: H
authors.lastname: Besiroglu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Erkoc
authors.forename: Eyyup
authors.initials: E
authors.lastname: Danis
authors.forename: Muammer
authors.initials: M
authors.lastname: Bozkurt
mesh_terms: D015992:Body Mass Index; D003920:Diabetes Mellitus; D018450:Disease Progression; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D060787:Neoplasm Grading; D009765:Obesity / Q000150:complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D001743:Urinary Bladder / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D019459:Urothelium / Q000473:pathology; D055105:Waist Circumference
chemical_list: D008075:Lipoproteins, HDL; D014280:Triglycerides