title: [Facial angiofibromas associated to tuberous sclerosis treated with topical sirolimus].
abstract: We present a five-year-old boy with facial angiofibromas associated to tuberous sclerosis successfully treated with topical sirolimus 0.4% applied three times a week for six months. After six months we observed a nearly complete resolution of facial angiofibromas. The blood levels of sirolimus remained under a detectable limit and no side-effects were observed. Topically applied sirolimus seems to be a safe and effective alternative to surgery or laser therapy.
authors.affiliation: Hudafdeling I og Allergicenter, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C. m_tiedemann@hotmail.com.
authors.forename: Mathias
authors.initials: M
authors.lastname: Tiedemann Svendsen
authors.forename: Anette
authors.initials: A
authors.lastname: Bygum
authors.forename: Lars Kjærsgaard
authors.initials: LK
authors.lastname: Hansen
authors.forename: Sigurd
authors.initials: S
authors.lastname: Broesby-Olsen
mesh_terms: D018322:Angiofibroma / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D005153:Facial Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009824:Ointments / Q000627:therapeutic use; D020123:Sirolimus / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000150:complications
chemical_list: D000903:Antibiotics, Antineoplastic; D007166:Immunosuppressive Agents; D009824:Ointments; D020123:Sirolimus