title: Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications.
abstract: Recently, substantial interest has been generated in using electrospun biomimetic nanofibers of hybrids, particularly organic/inorganic, to engineer different tissues. The present work, for the first time, introduced a unique natural and synthetic hybrid micronanofiber wound dressing, composed of virgin olive oil/copper oxide nanocrystals and polyurethane (PU), developed via facile electrospinning. The as-spun organic/inorganic hybrid micronanofibers were characterized by scanning electron microscopy (SEM), energy dispersive X-ray analysis, X-ray diffraction, electron probe microanalysis, and transmission electron microscopy. The interaction of cells with scaffold was studied by culturing NIH 3T3 fibroblasts on an as-spun hybrid micronanofibrous mat, and viability, proliferation, and growth were assessed. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay results and SEM observation showed that the hybrid micronanofibrous scaffold was noncytotoxic to fibroblast cell culture and was found to benefit cell attachment and proliferation. Hence our results suggest the potential utilization of as-spun micronanoscaffolds for tissue engineering. Copper oxide-olive oil/PU wound dressing may exert its positive beneficial effects at every stage during wound-healing progression, and these micronanofibers may serve diverse biomedical applications, such as tissue regeneration, damaged skin treatment, wound healing applications, etc. Conclusively, the fabricated olive oil-copper oxide/PU micronanofibers combine the benefits of virgin olive oil and copper oxide, and therefore hold great promise for biomedical applications in the near future.
authors.affiliation: Department of Animal Sciences and Biotechnology, Jeonju, South Korea.
authors.forename: Touseef
authors.initials: T
authors.lastname: Amna
authors.affiliation: Department of Organic Materials and Fiber Engineering, Chonbuk National University, Jeonju, South Korea.
authors.forename: M Shamshi
authors.initials: MS
authors.lastname: Hassan
authors.affiliation: Department of Animal Sciences and Biotechnology, Jeonju, South Korea.
authors.forename: Jieun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Organic Materials and Fiber Engineering, Chonbuk National University, Jeonju, South Korea.
authors.forename: Myung-Seob
authors.initials: MS
authors.lastname: Khil
authors.affiliation: Genomic Informatics Center, Hankyong National University, Anseong, South Korea.
authors.forename: Ki-Duk
authors.initials: KD
authors.lastname: Song
authors.affiliation: Genomic Informatics Center, Hankyong National University, Anseong, South Korea.
authors.forename: Jae-Don
authors.initials: JD
authors.lastname: Oh
authors.affiliation: Department of Animal Sciences and Biotechnology, Jeonju, South Korea.
authors.forename: Inho
authors.initials: I
authors.lastname: Hwang
mesh_terms: D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion; D003300:Copper / Q000737:chemistry; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D008855:Microscopy, Electron, Scanning; D041681:NIH 3T3 Cells; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D050997:Nanomedicine; D000069463:Olive Oil; D010938:Plant Oils / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry; D045663:Quantum Dots / Q000737:chemistry; D023822:Tissue Engineering / Q000379:methods; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D000069463:Olive Oil; D010938:Plant Oils; D011140:Polyurethanes; D003300:Copper; C030973:cupric oxide
keywords: copper oxide; micronanofibers; olive oil; polyurethane; wound healing