title: Antimicrobial and release study of drug loaded PVA/PEO/CMC wound dressings.
abstract: The aim of the present study was to develop PVA/PEO/CMC/aloe vera (PPCAV) and PVA/PEO/CMC/curcumin (PPCCu) dressings with nonwoven polyester fabric as the support layer via freeze-drying (FD) approach. Tetracycline hydrochloride drug (TC) was loaded along with curcumin and aloe vera on these dressings. The morphology of the dressings was characterized by scanning electron microscopy. The swelling behavior, water vapor transmission rate (WVTR), in vitro drug release and antimicrobial nature were analyzed to assess the applicability of these freeze-dried membranes as wound dressing materials. The results show that these dressings made from PPCAVTC and PPCCuTC were highly porous with three-dimensional interconnected porous morphology. The cumulative release of drug from the dressings increases with increasing immersion time and continued up to 24 h, after that it gets leveled off. These dressings evidenced wonderful antimicrobial nature in vitro. These dressings were found to have more than 900 % PBS uptake, WVTR was found to be in the range 2,000-2,500 gm(-2) day(-1). These dressings possess many characteristics desirable in an ideal wound dressing material.
authors.affiliation: Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology Delhi, New Delhi, 110016, India, bgupta@textile.iitd.ernet.in.
authors.forename: Bhuvanesh
authors.initials: B
authors.lastname: Gupta
authors.forename: Roopali
authors.initials: R
authors.lastname: Agarwal
authors.forename: M
authors.initials: M
authors.lastname: Sarwar Alam
mesh_terms: D000042:Absorption; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D001458:Bandages; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry; D004058:Diffusion; D004867:Equipment Design; D019544:Equipment Failure Analysis; D011092:Polyethylene Glycols / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D011092:Polyethylene Glycols; D011142:Polyvinyl Alcohol; D002266:Carboxymethylcellulose Sodium