title: TGF-β1 genotype in pediatric migraine patients.
abstract: There is no information about the role of transforming growth factor-beta 1 (TGF-β1) in the pathogenesis of pediatric migraine. This study included 100 consecutive children and adolescents in whom migraine was diagnosed and 88 healthy children and adolescents. The isolated genomic DNA was used as a template for TGFβ-1 (-800G/A, -509C/T, 869T/C [codon 10] and 915G/C [codon 25]) genotyping. The allelic frequency of 509C/T was significantly different between control and migraine without aura patients (P = .04). Codon 10 C/T genotypic and C10 C allelic frequency of TGF-β1 polymorphisms were significantly higher in migraine and migraine without aura patients versus healthy controls (P = .00; P = .00). To our knowledge, this is the first report dealing with the relationship between TGF-β1 genotype and migraine in the pediatric age group. Further studies related to this subject are needed, along with a search for new therapeutic agents with anti-inflammatory properties.
authors.affiliation: Department of Pediatrics, Division of Child Neurology, Baskent University Faculty of Medicine, Adana, Turkey semra_saygi@yahoo.com.
authors.forename: Semra
authors.initials: S
authors.lastname: Saygi
authors.affiliation: Department of Pediatrics, Division of Child Neurology, Baskent University Faculty of Medicine Ankara, Turkey.
authors.forename: Füsun
authors.initials: F
authors.lastname: Alehan
authors.affiliation: Department of Pediatrics, Division of Child Neurology, Baskent University Faculty of Medicine, Adana, Turkey.
authors.forename: İlknur
authors.initials: İ
authors.lastname: Erol
authors.affiliation: Department of Medical Biology, Baskent University School of Medicine, Ankara, Turkey.
authors.forename: Yaprak Yılmaz
authors.initials: YY
authors.lastname: Yalçın
authors.affiliation: Department of Medical Biology, Baskent University School of Medicine, Ankara, Turkey.
authors.forename: Fatma Belgin
authors.initials: FB
authors.lastname: Ataç
authors.affiliation: Kazan Vocational School Business Administration Program, Baskent University, Ankara, Turkey.
authors.forename: Gözde
authors.initials: G
authors.lastname: Kubat
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1
keywords: TGF-β1 genotype; children; cytokines; migraine