title: Primary adrenal leiomyosarcoma: case report and review of the literature.
abstract: Primary adrenal leiomyosarcoma is a very rare tumor with an unusual location; the diagnosis is based entirely on histological and immunohistochemical evaluations. We report a primary adrenal leiomyosarcoma in a 57-year-old woman who was incidentally found to have an adrenal-occupying lesion during a routine medical examination. Computed tomography revealed a 64 mm × 77 mm soft tissue mass in the left adrenal gland. The patient underwent left radical nephroadrenalectomy. Histological examination of the tumor showed malignant spindle cells in interlacing fasicles and whorls. Nuclear pleomorphism, tumor giant cells, necrosis, and abnormal mitotic figures were present. On immunohistochemistry, the tumor cells were strongly positive for smooth muscle actin, desmin, and vimentin expression, but negative for cytokeratin, CD117, CD34, CD68, Myoglobin, S100, and HMB-45.The final histopathological diagnosis was primary adrenal leiomyosarcoma.
authors.affiliation: Shaoxing People's Hospital, Shaoxing, Zhejiang Province, People's Republic of China mickmouse88@163.com.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wei
authors.affiliation: Shaoxing People's Hospital, Shaoxing, Zhejiang Province, People's Republic of China.
authors.forename: Aijing
authors.initials: A
authors.lastname: Sun
authors.affiliation: Shaoxing People's Hospital, Shaoxing, Zhejiang Province, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Tao
authors.affiliation: Shaoxing People's Hospital, Shaoxing, Zhejiang Province, People's Republic of China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Shaoxing People's Hospital, Shaoxing, Zhejiang Province, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D000311:Adrenal Glands / Q000473:pathology*; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology*; D008875:Middle Aged
keywords: adrenal gland; adrenal tumor; immunohistochemistry; leiomyosarcoma