title: Understanding and applying tyrosine biochemical diversity.
abstract: This review highlights some of the recent advances made in our understanding of the diversity of tyrosine biochemistry and shows how this has inspired novel applications in numerous areas of molecular design and synthesis, including chemical biology and bioconjugation. The pathophysiological implications of tyrosine biochemistry will be presented from a molecular perspective and the opportunities for therapeutic intervention explored.
authors.affiliation: Pfizer R&D, Chemical Biology Group, BioTherapeutics Chemistry, WorldWide Medicinal Chemistry, 200 Cambridge Park Drive, Cambridge, MA 02140, USA. lyn.jones@pfizer.com.
authors.forename: Lyn H
authors.initials: LH
authors.lastname: Jones
authors.forename: Arjun
authors.initials: A
authors.lastname: Narayanan
authors.forename: Erik C
authors.initials: EC
authors.lastname: Hett
mesh_terms: D000818:Animals; D004583:Electrons; D006801:Humans; D008958:Models, Molecular; D055672:Static Electricity; D014443:Tyrosine / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D014443:Tyrosine