title: Prognostic and assessment value of hyperglycemia and glycosylated hemoglobin in critical patients.
abstract: Hyperglycemia is common in critical patients and high blood glucose levels have a negative effect on their prognosis. The aim of this study was to investigate the effect of hyperglycemia and glycosylated hemoglobin (GHb) in critical patients. A total of 648 critical patients were enrolled in the study and received a random blood glucose test when they entered the emergency department. If blood glucose was more than 11.1 mM, a GHb test was followed within 24 h. All patients were followed up for 28 days. According to diabetes mellitus (DM) history, GHb value, and outcome of follow-up, patients were divided into different groups, and mortality rates were calculated, respectively. Hyperglycemia was found in 67.44% (437/648) of patients, and 51.49% (225/437) and 48.51% (212/437) had normal and elevated GHb levels, respectively. At the end of the follow-up period, 14 of the normal GHb patients and 32 of the elevated GHb patients died (6.22 and 15.09%, respectively). In the normal GHb group, 53 had a DM history, 23 were newly diagnosed with DM, and 149 had hospital-related hyperglycemia (HRH); the mortality rates were 11.32% (6/53), 8.70% (2/23), and 4.03% (6/149), respectively. In the elevated GHb group, 114 had a DM history, 83 were newly diagnosed with DM, and 15 had HRH; the mortality rates were 13.16% (15/114), 19.27% (16/83), and 6.67% (1/15), respectively. Hyperglycemia and GHb might play important roles in the prognosis and assessment for critical patients, and the prognosis would vary according to the different causes of hyperglycemia.
authors.affiliation: Emergency Department, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
authors.forename: X M
authors.initials: XM
authors.lastname: Che
authors.affiliation: Emergency Department, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Bai
authors.affiliation: Emergency Department, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Bu
authors.affiliation: Emergency Department, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Bai
authors.affiliation: Emergency Department, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China honghongpei@yeah.net.
authors.forename: H H
authors.initials: HH
authors.lastname: Pei
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D016638:Critical Illness; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods / Q000706:statistics & numerical data; D012307:Risk Factors; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin