title: The effectiveness of routine daily chlorhexidine gluconate bathing in reducing Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae skin burden among long-term acute care hospital patients.
abstract: We evaluated the effectiveness of daily chlorhexidine gluconate (CHG) bathing in decreasing skin carriage of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae (KPC) among long-term acute care hospital patients. CHG bathing reduced KPC skin colonization, particularly when CHG skin concentrations greater than or equal to 128 μg/mL were achieved.
authors.affiliation: Department of Medicine, Rush University Medical Center, Chicago, Illinois.
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Lin
authors.forename: Karen
authors.initials: K
authors.lastname: Lolans
authors.forename: Donald W
authors.initials: DW
authors.lastname: Blom
authors.forename: Rosie D
authors.initials: RD
authors.lastname: Lyles
authors.forename: Shayna
authors.initials: S
authors.lastname: Weiner
authors.forename: Kavya B
authors.initials: KB
authors.lastname: Poluru
authors.forename: Nicholas
authors.initials: N
authors.lastname: Moore
authors.forename: David W
authors.initials: DW
authors.lastname: Hines
authors.forename: Robert A
authors.initials: RA
authors.lastname: Weinstein
authors.forename: Mary K
authors.initials: MK
authors.lastname: Hayden
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis*; D001494:Baths / Q000379:methods*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006760:Hospitalization; D006801:Humans; D007710:Klebsiella Infections / Q000517:prevention & control*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000382:microbiology*; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase; C010882:chlorhexidine gluconate; D002710:Chlorhexidine