title: High dietary glycemic load is associated with increased risk of colon cancer.
abstract: High dietary glycemic load (GL) has been inconsistently associated with risk of colon cancer. We analyzed data for 1093 incident cases and 1589 controls in a population-based case-control study of colon cancer to further clarify the GL-colon cancer relationship. GL was assessed using a self-administered food frequency questionnaire. Cases had a significantly higher GL intake (mean = 136.4, SD = 24.5) than controls (mean = 132.8, SD = 25.2) (P = 0.0003). In a multivariate unconditional logistic regression model, the odds ratios (ORs) for colon cancer increased significantly with increasing GL: compared to the bottom quartile of GL, the ORs (95% CI) for the 2nd through the upper quartiles were 1.38 (1.06, 1.80), 1.67 (1.30, 2.13), and 1.61 (1.25, 2.07), respectively (P trend < 0.0001). Stratified analyses showed that the association was more pronounced among older participants [ORs (95% CI) for the 2nd through the upper quartiles were 1.35 (0.91, 2.00), 1.87 (1.29, 2.71), 2.02 (1.39, 2.95), respectively] than among younger participants [ORs were 1.46 (1.02, 2.10), 1.53 (1.09, 2.15), and 1.35 (0.96, 1.91), respectively] (P int = 0.02). Our results provide support for the hypothesis that a diet with high GL increases the risk of colon cancer.
authors.affiliation: a Department of Family Medicine and Community Health and Department of Epidemiology and Biostatistics , Case Western Reserve University , Cleveland , Ohio , USA.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Zelenskiy
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Thompson
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Tucker
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000209:etiology*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005247:Feeding Behavior; D005260:Female; D038321:Glycemic Index; D006801:Humans; D007629:Kentucky; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D004040:Dietary Carbohydrates