title: [Effect of jianpihuashi decoction on rats with hyperuricemia].
abstract: OBJECTIVE
  To investigate the effect of Jianpihuashi Decoction on rats with hyperuricemia.
  
  
  METHODS
  Forty male Sprague-Dawley (SD) rats were randomly divided into four groups: normal, hyperuricemia, Jianpihuashi Decoction and Allopurinol group. After the administration for 0 day, 10 days, 20 days and 30 days, the serum uric acid, creatinine, urea nitrogen and xanthine oxidase (XOD) activity levels were separately detected using the orbital blood. 30 days after the experiment, the rats were anaesthetized by 3% pentobarbital sodium, liver tissue homogenate extracts were used to detect the XOD activity, and histopathological changes in kidney were observed by HE staining.
  
  
  RESULTS
  Treatment with Jianpihuashi Decoction for 30 days, the serum uric acid level of rats with hyperuricemia were significantly decreased (P < 0.05). Simultaneously, the XOD activity in the serum and liver tissue homogenate extracts were obviously decreased by the decoction, which had seldom toxic or side effects on kidney. Allopurinol group could significantly decrease the serum uric acid level, but it had seldom pathological injury to kidney at the same time.
  
  
  CONCLUSIONS
  Jianpihuashi Decoction which has seldom pathological injury to kidney can significantly decrease the effect of uric acid by suppressing XOD activity.
authors.forename: Jian-Wen
authors.initials: JW
authors.lastname: Chen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Zhao-Yun
authors.initials: ZY
authors.lastname: Xue
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Guo
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Zhou
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Jiang
mesh_terms: D000493:Allopurinol / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D033461:Hyperuricemia / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014527:Uric Acid / Q000097:blood*; D014528:Uricosuric Agents / Q000494:pharmacology / Q000627:therapeutic use; D014969:Xanthine Oxidase / Q000097:blood / Q000378:metabolism*
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D014528:Uricosuric Agents; D014527:Uric Acid; D010094:Oxonic Acid; D000493:Allopurinol; D003404:Creatinine; D014969:Xanthine Oxidase