title: Epigenetics: What does it mean for paediatric practice?
abstract: 'Epigenetics' involves the study of gene expression and the environmental exposures that influence expression. In paediatrics, it is recognized that different physiological and developmental stages of the young individual are affected by both genetic control and environmental influence. It appears that changes in gene expression - not changes in the DNA itself - can be passed on from one generation to another. The importance for paediatricians is recognizing disorders involving epigenetics, recording events during childhood that could affect epigenetic control of gene expression, and being aware of new therapies as they become available. Paediatricians need to be able to recognize the relevant risk factors.
authors.affiliation: Departments of Medical Genetics and Pediatrics, University of British Columbia and BC Children's Hospital, Vancouver, British Columbia.
authors.forename: Judith G
authors.initials: JG
authors.lastname: Hall
keywords: Chromatin; Developmental origins of health and disease; Epigenetics; Gene control; Histones; Imprinting; Methylation; Paediatrics