title: [Absolute bioavailability of the adenine derivative VMA-99-82 possessing antiviral activity].
abstract: Investigation of the main pharmacokinetic parameters of adenine derivative VMA-99-82 in rats showed large values of the half-life (T1/2 = 11.03 h) and the mean retention time of drug molecules in the organism (MRT = 9.53 h). A high rate of the drug concentration decrease in the plasma determines a small value of the area under the pharmacokinetic curve (AUC = 74.96 mg h/ml). The total distribution volume (V(d) = 10.61 l/kg) is 15.8 times greater than the volume of extracellular fluid in the body of rat, which is indicative of a high ability of VMA-99-82 to be distributed and accumulated in the organs and tissues. The absolute bioavailability of VMA-99-82 is 66%.
authors.forename: L A
authors.initials: LA
authors.lastname: Smirnova
authors.forename: E A
authors.initials: EA
authors.lastname: Suchkov
authors.forename: A F
authors.initials: AF
authors.lastname: Riabukha
authors.forename: K A
authors.initials: KA
authors.lastname: Kuznetsov
authors.forename: A A
authors.initials: AA
authors.lastname: Ozerov
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D001682:Biological Availability; D006207:Half-Life; D008297:Male; D051381:Rats
chemical_list: D000998:Antiviral Agents; D000225:Adenine