title: Antifertility efficacy of Drynaria quercifolia (L.) J. Smith on female Wister albino rats.
abstract: BACKGROUND
  Plant based traditional medicines for birth control has been in practice in rural populations of North-East India, since time immemorial. Fresh rhizome of Drynaria quercifolia (L.) J. Smith is one of the plant parts used traditionally by different ethnic communities in Tripura, India for birth control. The present investigation is aimed to justify the scientific basis in traditional use of Drynaria quercifolia rhizome as anti-fertility agent.
  
  
  METHODS
  Ex-vivo uterotonic activity was done on uterine tissue. Acute toxicity test of the plant extract was carried out in rats of both sexes. The abortifacient and anti-implantation activities of the extract were investigated, in-vivo and estimated the level of different hormones release.
  
  
  RESULTS
  The result revealed the effectiveness of methanol (87%) and aqueous (68%) extract of the plant on uterotonic activity. The extracts showed relatively non-toxic effect in acute toxicity study. Methanolic extract has shown higher efficacy for both abortifacient (**p<0.01) and anti-implantation performance (**p<0.01) and also effected hormone release level (**p<0.01).
  
  
  CONCLUSIONS
  Methanolic extract of Drynaria quercifolia (L.) J. Smith rhizome has been proved to have significant anti-fertility activity.
authors.affiliation: Ethnobotany and Medicinal Plant Research laboratory, Dept.Department of Life Science and Bioinformatics, Assam University, Silchar 788011, India.
authors.forename: Banani
authors.initials: B
authors.lastname: Das
authors.affiliation: Pharmacology Laboratory, Natural Product Chemistry and Pharmacology Programme, Institute of Bioresources and Sustainable Development (IBSD), Department of Biotechnology, Government of India, Takyelpat, Imphal, Manipur 795001, India.
authors.forename: Amitabha
authors.initials: A
authors.lastname: Dey
authors.affiliation: Ethnobotany and Medicinal Plant Research laboratory, Dept.Department of Life Science and Bioinformatics, Assam University, Silchar 788011, India.
authors.forename: Anupam
authors.initials: A
authors.lastname: Das Talukdar
authors.affiliation: Pharmacology Laboratory, Natural Product Chemistry and Pharmacology Programme, Institute of Bioresources and Sustainable Development (IBSD), Department of Biotechnology, Government of India, Takyelpat, Imphal, Manipur 795001, India.
authors.forename: Kh
authors.initials: Kh
authors.lastname: Nongalleima
authors.affiliation: Ethnobotany and Medicinal Plant Research laboratory, Dept.Department of Life Science and Bioinformatics, Assam University, Silchar 788011, India. Electronic address: drmdc@bioinfoaus.ac.in.
authors.forename: Manabendra Dutta
authors.initials: MD
authors.lastname: Choudhury
authors.affiliation: Pharmacology Laboratory, Natural Product Chemistry and Pharmacology Programme, Institute of Bioresources and Sustainable Development (IBSD), Department of Biotechnology, Government of India, Takyelpat, Imphal, Manipur 795001, India. Electronic address: lokeshdeb.ibsd@nic.in.
authors.forename: Lokesh
authors.initials: L
authors.lastname: Deb
mesh_terms: D000818:Animals; D003271:Contraceptive Agents, Female / Q000302:isolation & purification / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects* / Q000502:physiology; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D029621:Polypodiaceae; D051381:Rats; D017208:Rats, Wistar; D027343:Rhizome; D016896:Treatment Outcome
chemical_list: D003271:Contraceptive Agents, Female; D010936:Plant Extracts
keywords: Antifertility agent; Contraceptive; Drynaria quercifolia (L.) J. Smith; Medicinal plants