title: Skin cancers after liver transplantation: retrospective single-center study on 371 recipients.
abstract: BACKGROUND
  The increased risk of skin cancer is well known in heart and kidney transplant recipients, but fewer data exist on liver-transplant recipients (LTRs). The aim of this study was to analyze the prevalence, clinical features and risk factors of skin cancers in LTR treated mainly with tacrolimus.
  
  
  METHODS
  We selected LTR grafted in our hospital between January 1996 and December 2008, aged 20 years or more at the time of the study. Data were collected from the patients' medical files and with a questionnaire.
  
  
  RESULTS
  Three hundred seventy-one LTR were included. The median follow-up period was 8.2 years. The overall prevalence of skin cancers was 13.5%. The prevalence of melanoma was 1.3%. The squamous cell carcinoma to basal cell carcinoma ratio was 1:3. Both the overall cumulative patient risk of de novo skin malignancies and the squamous cell carcinoma-to-basal cell carcinoma ratio increased with time postgraft. The duration of immunosuppression was a risk factor, in addition to those common in the general population. No association was found between the primary liver disease and the development of skin cancer.
  
  
  CONCLUSIONS
  Contrasting with previous data of the literature, our findings suggest that, for a similar follow-up time, the risk of skin cancer in LTR is comparable to that of kidney transplant recipients.
authors.affiliation: 1 Hospices Civils de Lyon, Edouard Herriot Hospital Group, Department of Dermatology, Lyon, France. 2 Hospices Civils de Lyon, Edouard Herriot Hospital Group, Department of Digestive Surgery and Transplantation, Lyon, France. 3 Hospices Civils de Lyon, Pôle Information Médicale Evaluation Recherche, Unité de Recherche Clinique, Lyon, France. 4 Université de Lyon, EAM Santé Individu Société, Lyon, France. 5 Université Lyon, Lyon, France. 6 Hospices Civils de Lyon, Edouard Herriot Hospital Group, Department of Liver Transplantation, Lyon, France. 7 Address correspondence to: Emilie Ducroux, M.D., Department of Dermatology, Edouard Herriot Hospital Group, 5 Place d'Arsonval 69437 Lyon cedex 03, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Ducroux
authors.forename: Olivier
authors.initials: O
authors.lastname: Boillot
authors.forename: Maria Andrea
authors.initials: MA
authors.lastname: Ocampo
authors.forename: Evelyne
authors.initials: E
authors.lastname: Decullier
authors.forename: Adeline
authors.initials: A
authors.lastname: Roux
authors.forename: Jérôme
authors.initials: J
authors.lastname: Dumortier
authors.forename: Jean
authors.initials: J
authors.lastname: Kanitakis
authors.forename: Denis
authors.initials: D
authors.lastname: Jullien
authors.forename: Sylvie
authors.initials: S
authors.lastname: Euvrard
mesh_terms: D002280:Basal Cell Carcinoma / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000209:etiology; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology*