title: Weight change in patients attempting to quit smoking post-myocardial infarction.
abstract: BACKGROUND
  Current guidelines recommend smoking cessation and weight management for secondary prevention in patients post-myocardial infarction. However, little is known about the effects of smoking cessation on weight change post-myocardial infarction.
  
  
  METHODS
  We examined patterns of weight change and its effects on blood pressure and glycemic control using data from a randomized trial investigating the effect of bupropion on smoking cessation in patients post-myocardial infarction. Weight change was compared among 3 groups of patients: those who were completely abstinent (n = 92), those who smoked intermittently (n = 49), and those who smoked persistently (n = 38) during the 12-month follow-up. Analyses were restricted to patients who attended all follow-up visits.
  
  
  RESULTS
  The median weight at baseline was 77.1 kg (interquartile range [IQR], 66.0, 87.5), and 64.3% of patients were overweight/obese (body mass index ≥25.0 kg/m(2)). The median weight gain at 12 months was 4.0 kg (IQR, 0-7.0), with more than one third gaining >5 kg. The proportion of patients who were overweight/obese increased by approximately 10%, and 23.2% of patients moved up a body mass index category. Abstainers gained a median of 4.8 kg (IQR, 1.0, 8.6), intermittent smokers gained a median of 2.0 kg (IQR, -2.0, 5.0), and persistent smokers gained a median of 3.0 kg (IQR, -0.8, 6.0). Weight gain was associated with an increase in blood pressure and requirements for hypoglycemic medications at 12 months.
  
  
  CONCLUSIONS
  The majority of patients attempting to quit smoking gain weight 12 months post-myocardial infarction, with abstainers gaining more weight than those who return to smoking. Weight gain was associated with an increased prevalence of hypertension and diabetes.
authors.affiliation: Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, Lady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, Quebec, Canada.
authors.forename: Sonia M
authors.initials: SM
authors.lastname: Grandi
authors.affiliation: Division of Clinical Epidemiology, Lady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada.
authors.forename: Kristian B
authors.initials: KB
authors.lastname: Filion
authors.affiliation: Agence de la santé et des services sociaux, Direction de santé publique, Montreal, Quebec, Canada.
authors.forename: André
authors.initials: A
authors.lastname: Gervais
authors.affiliation: Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada; Research Institute, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Joseph
authors.affiliation: CRCHUM and the Department of Social and Preventive Medicine, Université de Montreal, Montreal, Quebec, Canada.
authors.forename: Jennifer
authors.initials: J
authors.lastname: O'Loughlin
authors.affiliation: Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Research Institute, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
authors.forename: Gilles
authors.initials: G
authors.lastname: Paradis
authors.affiliation: Multidisciplinary Cardiology Department, Institut universitaire de cardiologie et de pneumologie de Quebec (Quebec Heart and Lung Institute), Quebec City, Quebec, Canada.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Rinfret
authors.affiliation: Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada; CRCHUM and the Department of Social and Preventive Medicine, Université de Montreal, Montreal, Quebec, Canada; Division of General Internal Medicine, McGill University Health Centre, Montreal, Quebec, Canada.
authors.forename: Louise
authors.initials: L
authors.lastname: Pilote
authors.affiliation: CHA Hôtel-Dieu de Lévis, Lévis, Quebec, Canada.
authors.forename: François R
authors.initials: FR
authors.lastname: Grondin
authors.affiliation: New Brunswick Heart Centre, Saint John, New Brunswick, Canada.
authors.forename: Sohrab
authors.initials: S
authors.lastname: Lutchmedial
authors.affiliation: Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, Lady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada. Electronic address: mark.eisenberg@mcgill.ca.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Eisenberg
mesh_terms: D001794:Blood Pressure; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology; D016540:Smoking Cessation; D015430:Weight Gain
chemical_list: D007004:Hypoglycemic Agents
keywords: Myocardial infarction; Randomized controlled trial; Smoking cessation; Weight change