title: Working memory abilities among children treated for medulloblastoma: parent report and child performance.
abstract: OBJECTIVE
  We investigated the 5-year postsurgical developmental trajectory of working memory (WM) in children with medulloblastoma using parent and performance-based measures.
  
  
  METHODS
  This study included 167 patients treated for medulloblastoma. Serial assessments of WM occurred at predetermined time points for 5 years.
  
  
  RESULTS
  There was a subtle, statistically significant increase in parental concern about WM, coupled with a statistically significant decrease in age-standardized scores on performance-based measures. However, whole-group mean scores on both parent and performance-based measures remained in the age-expected range. Posterior fossa syndrome was consistently associated with poorer WM. Younger age at treatment and higher treatment intensity were associated with greater negative change in WM performance only.
  
  
  CONCLUSIONS
  Most children treated for medulloblastoma display WM within the age-appropriate range according to parent report and performance. However, the subtle negative changes over time and identified subgroups at increased risk highlight the need for ongoing monitoring of this population.
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research HospitalClinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research HospitalClinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, D
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Knight
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Conklin
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Shawna L
authors.initials: SL
authors.lastname: Palmer
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Schreiber
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Carol L
authors.initials: CL
authors.lastname: Armstrong
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Dana
authors.initials: D
authors.lastname: Wallace
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Melanie
authors.initials: M
authors.lastname: Bonner
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Swain
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Karen D
authors.initials: KD
authors.lastname: Evankovich
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Mabbott
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Robyn
authors.initials: R
authors.lastname: Boyle
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Qinlei
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research HospitalClinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Vicki A
authors.initials: VA
authors.lastname: Anderson
authors.affiliation: Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
authors.forename: Amar
authors.initials: A
authors.lastname: Gajjar
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002528:Cerebellar Neoplasms / Q000523:psychology* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000523:psychology* / Q000601:surgery; D008570:Memory, Short-Term; D009483:Neuropsychological Tests; D010290:Parents; D055815:Young Adult
keywords: cancer and oncology; cognitive assessment; neurological disorders; neuropsychology