title: Unraveling hepatitis C virus structure.
abstract: The high variability and the limited knowledge of the structure of the hepatitis C virus (HCV) envelope glycoproteins (GP) are challenging hurdles for vaccine design. Recently, Kong et al. published a new model of HCV E2 GP structure in Science, revealing a globular structure, starkly contrasting from the extended model of class II fusion proteins from other Flaviviridae viruses.
authors.affiliation: 1] Inserm Unit 1110, Université de Strasbourg, 3 rue Koeberlé, F-67000 Strasbourg, France [2] Pôle Hépato-digestif, Université de Strasbourg, Strasbourg, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Fauvelle
authors.affiliation: 1] Inserm Unit 1110, Université de Strasbourg, 3 rue Koeberlé, F-67000 Strasbourg, France [2] Pôle Hépato-digestif, Université de Strasbourg, Strasbourg, France.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Felmlee
authors.affiliation: 1] Inserm Unit 1110, Université de Strasbourg, 3 rue Koeberlé, F-67000 Strasbourg, France [2] Pôle Hépato-digestif, Université de Strasbourg, Strasbourg, France [3] Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Baumert
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology*; D016174:Hepacivirus / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing