title: Keratosis pilaris and prevalence of acne vulgaris: a cross-sectional study.
abstract: BACKGROUND
  Acne vulgaris has an important genetic predisposition, as well as keratosis pilaris. Clinical observations suggest that patients with keratosis pilaris have less frequent or less severe acne breakouts; however, we found no studies on this regard
  
  
  OBJECTIVE
  To determine if the presence of keratosis pilaris is associated with lower prevalence and severity of acne.
  
  
  METHODS
  A cross-sectional study was conducted with dermatology outpatients aged between 14 and 35 years. We evaluated history and clinical grade of acne, demographic variables, history of atopy, smoking, and use of hormonal contraceptives. Two groups were defined by the presence or absence of moderate to severe keratosis pilaris on the arms and were compared by bivariate analysis and by conditional multiple logistic regression.
  
  
  RESULTS
  We included 158 patients (66% women), with a median age of 23 ± 11 years. Twenty-six percent of them had keratosis pilaris, which was associated with a history of atopy (odds ratio [OR]=2.80 [1.36 to 5.75]; p<0.01). Acne was present in 66% of subjects, and was related to family history of acne (OR=5.75 [2.47 to 13.37]; p<0.01). In bivariate and multivariate analysis, the group with keratosis pilaris had a less frequent history of acne (OR=0.32 [0.14 to 0.70]; p<0.01).
  
  
  CONCLUSIONS
  The presence of moderate to severe keratosis pilaris on the arms was associated with lower prevalence of acne vulgaris and lower severity of facial lesions in adolescents and young adults.
authors.affiliation: Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Medicina de Botucatu, Department of Dermatology and Radiation Therapy, BotucatuSP, Brasil, PhD - Assistant Professor of the Department of Dermatology and Radiation Therapy of Faculdade de Medicina de Botucatu - Universidade Estadual Paulista "Júlio de Mesquita Filho" (FMB-UNESP) - Botucatu (SP), Brasil.
authors.forename: Juliano Vilaverde
authors.initials: JV
authors.lastname: Schmitt
authors.affiliation: Faculdade Evangélica do Paraná, Hospital Universitário Evangélico de Curitiba, CuritibaPR, Brasil, Resident at the Dermatology service of Hospital Universitário Evangélico de Curitiba - Faculdade Evangélica do Paraná (HUEC-FEPAR) - Curitiba (PR), Brasil.
authors.forename: Brunno Zeni de
authors.initials: BZ
authors.lastname: Lima
authors.affiliation: Faculdade Evangélica do Paraná, Hospital Universitário Evangélico de Curitiba, CuritibaPR, Brasil, Resident at the Dermatology service of Hospital Universitário Evangélico de Curitiba - Faculdade Evangélica do Paraná (HUEC-FEPAR) - Curitiba (PR), Brasil.
authors.forename: Monique Carolina Meira do Rosário de
authors.initials: MC
authors.lastname: Souza
authors.affiliation: Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Medicina de Botucatu, Department of Dermatology and Radiation Therapy, BotucatuSP, Brasil, PhD - Assistant Professor of the Department of Dermatology and Radiation Therapy of Faculdade de Medicina de Botucatu - Universidade Estadual Paulista "Júlio de Mesquita Filho" (FMB-UNESP) - Botucatu (SP), Brasil.
authors.forename: Hélio Amante
authors.initials: HA
authors.lastname: Miot
mesh_terms: D000015:Abnormalities, Multiple / Q000453:epidemiology* / Q000503:physiopathology; D000152:Acne Vulgaris / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D007644:Darier Disease / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D005138:Eyebrows / Q000002:abnormalities* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D012737:Sex Factors; D034941:Upper Extremity / Q000503:physiopathology; D055815:Young Adult