title: HIV-1 Rev multimerization: mechanism and insights.
abstract: To export intron-containing viral mRNAs that encode the structural components of new viral particles from the nucleus to the cytoplasm, HIV-1 uses the cellular CRM1 export pathway that is exploited by the viral Rev protein. Rev multimerizes on the Rev response element (RRE) present in the intron-containing RNA species to bridge these to the cellular export factor CRM1. As a result, this Rev-RRE complex is exported to the cytoplasm. This review provides a systematic overview of different aspects of the crucial function of Rev multimerization, such as co-operative Rev-Rev and Rev-RNA interactions, the biological function of Rev multimerization, the relevance of Rev multimerization in the absence of RRE and its potential as a therapeutic target.
authors.forename: Thomas
authors.initials: T
authors.lastname: Vercruysse
authors.affiliation: Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium. dirk.daelemans@rega.kuleuven.be.
authors.forename: Dirk
authors.initials: D
authors.lastname: Daelemans
mesh_terms: D001692:Biological Transport; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D015967:Gene Expression Regulation, Viral; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D028884:Karyopherins / Q000378:metabolism; D055503:Protein Multimerization / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D054321:rev Gene Products, Human Immunodeficiency Virus / Q000502:physiology*; D000097606:Exportin 1 Protein
chemical_list: D028884:Karyopherins; D012333:RNA, Messenger; D012367:RNA, Viral; D018160:Receptors, Cytoplasmic and Nuclear; D054321:rev Gene Products, Human Immunodeficiency Virus; D000097606:Exportin 1 Protein