title: Oxidative coupling of methylamine with an aminyl radical: direct amidation catalyzed by I2/TBHP with HCl.
abstract: Oxidative coupling of methylamines with an aminyl radical to construct amides was developed in the presence of an I2/TBHP catalyst under acidic conditions via the two cleavages of the sp(3) C-N bond of aryl-methylamines and the sp(2) C-N bond of N-substituted formamides respectively. This transition-metal-free protocol provides a novel synthetic tool for the construction of N-substituted amides and a series of arylamides can be easily obtained with good yields.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei, 230026, P. R. China. zwang3@ustc.edu.cn.
authors.forename: Lingfeng
authors.initials: L
authors.lastname: Gao
authors.forename: Haoming
authors.initials: H
authors.lastname: Tang
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D005559:Formamides / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D008744:Methylamines / Q000737:chemistry*; D058451:Oxidative Coupling; D020122:tert-Butylhydroperoxide / Q000737:chemistry*
chemical_list: D005559:Formamides; D008744:Methylamines; D020122:tert-Butylhydroperoxide; D007455:Iodine