title: Cell therapy in reperfused acute myocardial infarction does not improve the recovery of perfusion in the infarcted myocardium: a cardiac MR imaging study.
abstract: OBJECTIVE
  To investigate the effects of cell therapy on myocardial perfusion recovery after treatment of acute myocardial infarction (MI) with primary percutaneous coronary intervention (PCI).
  
  
  METHODS
  In this HEBE trial substudy, which was approved by the institutional review board (trial registry number ISRCTN95796863), the authors assessed the effects of intracoronary infusion with bone marrow-derived mononuclear cells (BMMCs) or peripheral blood-derived mononuclear cells (PBMCs) on myocardial perfusion recovery by using cardiac magnetic resonance (MR) imaging after revascularization. In 152 patients with acute MI treated with PCI, cardiac MR imaging was performed after obtaining informed consent-before randomization to BMMC, PBMC, or standard therapy (control group)-and repeated at 4-month follow-up. Cardiac MR imaging consisted of cine, rest first-pass perfusion, and late gadolinium enhancement imaging. Perfusion was evaluated semiquantitatively with signal intensity-time curves by calculating the relative upslope (percentage signal intensity change). The relative upslope was calculated for the MI core, adjacent border zone, and remote myocardium. Perfusion differences among treatment groups or between baseline and follow-up were assessed with the Wilcoxon signed rank or Mann-Whitney U test.
  
  
  RESULTS
  At baseline, myocardial perfusion differed between the MI core (median, 6.0%; interquartile range [IQR], 4.1%-8.0%), border zone (median, 8.4%; IQR, 6.4%-10.2%), and remote myocardium (median, 12.2%; IQR, 10.5%-15.9%) (P < .001 for all), with equal distribution among treatment groups. These interregional differences persisted at follow-up (P < .001 for all). No difference in perfusion recovery was found between the three treatment groups for any region.
  
  
  CONCLUSIONS
  After revascularization of ST-elevation MI, cell therapy does not augment the recovery of resting perfusion in either the MI core or border zone.
authors.affiliation: From the Department of Cardiology, VU University Medical Center, Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands (L.F.H.J.R., R.N., A.M.B., M.B.M.H., A.C.v.R.); ICIN-Netherlands Heart Institute (ICIN-NHI), Utrecht, the Netherlands (L.F.H.J.R., R.N., A.H., A.M.v.d.L., R.D., P.A.v.d.V.); Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands (A.H., A.M.v.d.L., R.D., J.G.P.T., J.J.P.); Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (P.A.v.d.V., R.A.T.); and Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (F.Z.).
authors.forename: Lourens F H J
authors.initials: LF
authors.lastname: Robbers
authors.forename: Robin
authors.initials: R
authors.lastname: Nijveldt
authors.forename: Aernout M
authors.initials: AM
authors.lastname: Beek
authors.forename: Alexander
authors.initials: A
authors.lastname: Hirsch
authors.forename: Anja M
authors.initials: AM
authors.lastname: van der Laan
authors.forename: Ronak
authors.initials: R
authors.lastname: Delewi
authors.forename: Pieter A
authors.initials: PA
authors.lastname: van der Vleuten
authors.forename: René A
authors.initials: RA
authors.lastname: Tio
authors.forename: Jan G P
authors.initials: JG
authors.lastname: Tijssen
authors.forename: Mark B M
authors.initials: MB
authors.lastname: Hofman
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Piek
authors.forename: Felix
authors.initials: F
authors.lastname: Zijlstra
authors.forename: Albert C
authors.initials: AC
authors.lastname: van Rossum
mesh_terms: D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation; D055424:Cardiac-Gated Imaging Techniques; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D003131:Combined Modality Therapy; D003287:Contrast Media; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007963:Leukocytes, Mononuclear / Q000637:transplantation*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology* / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000473:pathology* / Q000628:therapy*; D009206:Myocardium / Q000473:pathology*; D018919:Neovascularization, Physiologic; D009942:Organometallic Compounds; D062645:Percutaneous Coronary Intervention; D020127:Recovery of Function; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine