title: A new ursane-type triterpene, cymosic acid from Rosa cymosa.
abstract: A new ursane-type triterpene, cymosic acid (1) together with two known compounds, 3β,19α-dihydroxy-2-oxo-12-ursen-28-oic acid (2) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (3), were isolated from Rosa cymosa Tratt. The structure of compound 1 was elucidated by analyzing its ¹H and ¹³C NMR, ¹H-¹H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS values. The three compounds were found to display moderate inhibitory activities against nitric oxide production in lipopolysaccharide-activated macrophage cell lines, RAW 264.7 cells.
authors.affiliation: a College of Pharmaceutical Science, Zhejiang Chinese Medical University , Hangzhou 310053 , China.
authors.forename: Xiao-Peng
authors.initials: XP
authors.lastname: Wu
authors.forename: Xiao-Po
authors.initials: XP
authors.lastname: Zhang
authors.forename: Guo-Xu
authors.initials: GX
authors.lastname: Ma
authors.forename: Mo
authors.initials: M
authors.lastname: Han
authors.forename: Mu-Die
authors.initials: MD
authors.lastname: Xu
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wu
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Huang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Huang
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Yang
authors.forename: Jing-Quan
authors.initials: JQ
authors.lastname: Yuan
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xu
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zhong
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D027826:Rosa / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C523151:3-oxo-12-ursen-28-oic acid; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D014315:Triterpenes; C000588523:cymosic acid; D009569:Nitric Oxide