title: Role of Triticum aestivum aqueous extract in glucocorticoid induced osteoporosis in rats.
abstract: Administration of aqueous extract of T. aestivum (200 and 400 mg/kg/day, po, for 30 days) and risedronate (20 microg/kg, sc, five times a week for 30 days) following methyl prednisolone sodium succinate (10 mg/kg, sc, thrice a week for 4 weeks) induced osteoporosis in Wistar rats showed an increase in the serum levels of bone mineral content markers, decrease in the serum and urinary levels of bone resorption markers. An incline in strength of femur and tibia was seen particularly with 400 mg/kg of T. aestivum. Maintenance of calcium homeostasis, formation of collagen and scavenging of free radicals can plausibly be the mode of action of aqueous extract of T. aestivum thereby combating osteoporosis induced by glucocorticoids.
authors.affiliation: Department of Pharmacology, Nalanda College of Pharmacy, Charlapally, Nalgonda 508 001, India. davidbanji@gmail.com
authors.forename: David
authors.initials: D
authors.lastname: Banji
authors.affiliation: Department of Pharmacology, Nalanda College of Pharmacy, Charlapally, Nalgonda 508 001, India.
authors.forename: Otilia J F
authors.initials: OJ
authors.lastname: Banji
authors.affiliation: Department of Pharmacology, Nalanda College of Pharmacy, Charlapally, Nalgonda 508 001, India.
authors.forename: Vijaya Laxmi
authors.initials: VL
authors.lastname: Chiluka
authors.affiliation: Department of Pharmacology, Nalanda College of Pharmacy, Charlapally, Nalgonda 508 001, India.
authors.forename: Saidulu
authors.initials: S
authors.lastname: Abbagoni
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001862:Bone Resorption / Q000188:drug therapy* / Q000378:metabolism; D003094:Collagen / Q000096:biosynthesis; D012968:Etidronic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D016166:Free Radical Scavengers / Q000008:administration & dosage; D005938:Glucocorticoids / Q000633:toxicity; D008297:Male; D010024:Osteoporosis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D011239:Prednisolone / Q000008:administration & dosage; D051381:Rats; D000068296:Risedronic Acid; D013977:Tibia / Q000187:drug effects / Q000378:metabolism; D014908:Triticum / Q000737:chemistry*
chemical_list: D016166:Free Radical Scavengers; D005938:Glucocorticoids; D010936:Plant Extracts; D003094:Collagen; D011239:Prednisolone; D000068296:Risedronic Acid; D012968:Etidronic Acid