title: Early changes in serum visfatin after abdominal surgery: a new pro-inflammatory marker in diagnosis?
abstract: BACKGROUND
  Visfatin is an adipocytokine produced primarily by visceral adipose tissue. In addition to its effect on the insulin receptor, it is a proinflammmatory cytokine with accumulating evidence for its rise in circulation, accompanying systemic inflammation. The aim of this study was to evaluate changes in serum visfatin levels in the early post-abdominal surgery period with serum levels of other proinflammatory cytokines, to determine whether it could be used as a marker of inflammation.
  
  
  RESULTS
  This was a prospective cross-sectional study of 42 patients undergoing elective laparotomic right hemicolectomy for adenocarcinoma colon. The parameters determined were visfatin, leptin, adiponectin, TNF α, interleukin-6 and C-reactive protein levels. The dynamics of change in these markers were assessed at +12, +24, +48, and +72 h after surgery. Serum levels of visfatin peaked as early as 24 h post-surgery, returning to normal after 72 h. TNF α and IL-6 levels reached their maximum 12 to 24 h later while CRP levels peaked after 72 h.
  
  
  CONCLUSIONS
  Significantly increased serum levels of visfatin detected in the early period after abdominal surgery preceded increase in the levels of other proinflammatory markers including TNF α, IL-6, and CRP. Given its dynamics, visfatin could serve as an early predictor of the development of inflammatory changes in patients undergoing surgery, particularly those with obesity (BMI > 30 kg/m(2)).
authors.affiliation: Department of Surgery, 3rd Faculty of Medicine, Charles University in Prague and Kralovske Vinohrady University Hospital, Prague, Czech Republic.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Teplan
authors.affiliation: Institute of Rheumatology, 1st Faculty of Medicine, Charles University in Prague and General University Hospital, Prague.
authors.forename: Ladislav
authors.initials: L
authors.lastname: Senolt
authors.affiliation: Institute of Rheumatology, 1st Faculty of Medicine, Charles University in Prague and General University Hospital, Prague.
authors.forename: Hana
authors.initials: H
authors.lastname: Hulejova
authors.affiliation: Department of Nephrology, Transplant Center, Institute for Clinical and Experimental Medicine, Prague.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Teplan
authors.affiliation: Department of Nephrology, Transplant Center, Institute for Clinical and Experimental Medicine, Prague.
authors.forename: Milena
authors.initials: M
authors.lastname: Stollova
authors.affiliation: Department of Surgery, 3rd Faculty of Medicine, Charles University in Prague and Kralovske Vinohrady University Hospital, Prague, Czech Republic.
authors.forename: Robert
authors.initials: R
authors.lastname: Gurlich
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000601:surgery*; D014408:Biomarkers, Tumor / Q000097:blood; D003082:Colectomy; D003110:Colonic Neoplasms / Q000097:blood / Q000601:surgery*; D003430:Cross-Sectional Studies; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011183:Postoperative Complications / Q000097:blood* / Q000453:epidemiology; D011184:Postoperative Period; D015995:Prevalence; D011446:Prospective Studies
chemical_list: D014408:Biomarkers, Tumor; D054409:Nicotinamide Phosphoribosyltransferase
keywords: abdominal surgery; proinflammatory cytokines; visceral obesity; visfatin