title: Identification of clinical features of lymphoma-associated hemophagocytic syndrome (LAHS): an analysis of 69 patients with hemophagocytic syndrome from a single-center in central region of China.
abstract: To identify the clinical features of lymphoma-associated hemophagocytic syndrome (LAHS), we retrospectively analyzed the clinical characteristics, laboratory findings and survival data of 16 LAHS patients from 69 adult hemophagocytic syndrome (HPS) patients. The results showed that the most common clinical manifestations and laboratory parameters were fever (100%), ferritin ≥ 500 g/L (100%), peripheral cytopenia in two or more lineages (100%), fibrinogen (Fbg) < 1.5 g/L (93.8%) and splenomegaly (81.3%) in LAHS patients. The percentages of patients with Fbg < 1.5 g/L, PLT < 40 × 10(9)/L and LDH ≥ 1,000 U/L in the LAHS group were significantly higher than those in non-LAHS patients (P = 0.010, 0.000, and 0.001, respectively). Survival analysis showed that HLH patients with rheumatological reasons had better prognosis (OS; median not reached), followed by patients in the infection group (350 days) and those with unexplained causes (140 days). LAHS had the worst prognosis (only 37 days). The symptoms of LAHS patients are usually confused with other HPS. Patients with LAHS had higher probabilities to have Fbg < 1.5 g/L, PLT < 40 × 10(9)/L, LDH ≥ 1,000 U/L and poor prognosis, so early diagnosis and systemic treatments are required.
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Nanchang University, #17 Yongwai Zheng Street, Nanchang, Jiangxi Province, 330006, China, yx021021@sina.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Pu
authors.initials: P
authors.lastname: Li
authors.forename: Rongyan
authors.initials: R
authors.lastname: Zhang
authors.forename: Ganping
authors.initials: G
authors.lastname: Yang
authors.forename: Dexiang
authors.initials: D
authors.lastname: Ji
authors.forename: Xianbao
authors.initials: X
authors.lastname: Huang
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Wei
authors.forename: Jia
authors.initials: J
authors.lastname: Rao
authors.forename: Ruibing
authors.initials: R
authors.lastname: Huang
authors.forename: Guoan
authors.initials: G
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D001772:Blood Cell Count; D002681:China; D005260:Female; D005293:Ferritins / Q000097:blood; D005340:Fibrinogen / Q000378:metabolism; D015321:Gene Rearrangement; D005843:Geography; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000453:epidemiology; D008223:Lymphoma / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011379:Prognosis; D013163:Splenomegaly / Q000150:complications; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005340:Fibrinogen; D005293:Ferritins