title: Percutaneous bone biopsies: comparison between flat-panel cone-beam CT and CT-scan guidance.
abstract: OBJECTIVE
  This study was designed to compare the accuracy of targeting and the radiation dose of bone biopsies performed either under fluoroscopic guidance using a cone-beam CT with real-time 3D image fusion software (FP-CBCT-guidance) or under conventional computed tomography guidance (CT-guidance).
  
  
  METHODS
  Sixty-eight consecutive patients with a bone lesion were prospectively included. The bone biopsies were scheduled under FP-CBCT-guidance or under CT-guidance according to operating room availability. Thirty-four patients underwent a bone biopsy under FP-CBCT and 34 under CT-guidance. We prospectively compared the two guidance modalities for their technical success, accuracy, puncture time, and pathological success rate. Patient and physician radiation doses also were compared.
  
  
  RESULTS
  All biopsies were technically successful, with both guidance modalities. Accuracy was significantly better using FP-CBCT-guidance (3 and 5 mm respectively: p = 0.003). There was no significant difference in puncture time (32 and 31 min respectively, p = 0.51) nor in pathological results (88 and 88 % of pathological success respectively, p = 1). Patient radiation doses were significantly lower with FP-CBCT (45 vs. 136 mSv, p < 0.0001). The percentage of operators who received a dose higher than 0.001 mSv (dosimeter detection dose threshold) was lower with FP-CBCT than CT-guidance (27 vs. 59 %, p = 0.01).
  
  
  CONCLUSIONS
  FP-CBCT-guidance for bone biopsy is accurate and reduces patient and operator radiation doses compared with CT-guidance.
authors.affiliation: Interventional Radiology Department, Gustave Roussy, 114 rue Edouard Vaillant, 94805, Villejuif, France, lambros.tselikas@gmail.com.
authors.forename: Lambros
authors.initials: L
authors.lastname: Tselikas
authors.forename: Julien
authors.initials: J
authors.lastname: Joskin
authors.forename: Florian
authors.initials: F
authors.lastname: Roquet
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Farouil
authors.forename: Serge
authors.initials: S
authors.lastname: Dreuil
authors.forename: Antoine
authors.initials: A
authors.lastname: Hakimé
authors.forename: Christophe
authors.initials: C
authors.lastname: Teriitehau
authors.forename: Anne
authors.initials: A
authors.lastname: Auperin
authors.forename: Thierry
authors.initials: T
authors.lastname: de Baere
authors.forename: Frederic
authors.initials: F
authors.lastname: Deschamps
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology*; D054893:Cone-Beam Computed Tomography / Q000379:methods; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011829:Radiation Dosage; D015641:Radiography, Interventional / Q000379:methods*; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*