title: Comparative study of macular ganglion cell complex thickness measured by spectral-domain optical coherence tomography in healthy eyes, eyes with preperimetric glaucoma, and eyes with early glaucoma.
abstract: OBJECTIVE
  To evaluate the diagnostic accuracy of Topcon 3D spectral-domain optical coherence tomography (SD-OCT) for measuring the macular inner retinal layers and the circumpapillary retinal nerve fiber layer (cpRNFL) in order to detect preperimetric glaucoma.
  
  
  METHODS
  Two hundred four eyes, including 64 healthy eyes, 68 eyes with preperimetric glaucoma, and 72 eyes with early glaucoma were analyzed. Patients had a comprehensive ocular examination including visual field testing and SD-OCT imaging (3D OCT-2000; Topcon Corporation, Tokyo, Japan) in the macular and peripapillary regions. OCT macular scans were segmented into the macular nerve fiber layer (mNFL), ganglion cell layer with the inner plexiform layer (GCIP), and ganglion cell complex (GCC) (composed of the mNFL and GCIP). Ability to discriminate preperimetric glaucoma was assessed using the area under the receiver operating curve for all macular parameters and the cpRNFL.
  
  
  RESULTS
  The median visual field MD was -0.78 ± 1.19 dB for the healthy group, -1.02 ± 1.29 dB for the preperimetric glaucoma group, and -3.08 ± 1.61 dB for the early glaucoma group. There were significant differences between the preperimetric and healthy groups for GCIP and GCC and for almost all cpRNFL thickness parameters (P < 0.05), except for the mNFL and cpRNFL (nasal, 3, 4, 8, 9, and 10 o'clock sectors). The comparisons among the AUCs of the cpRNFL parameters (0.772), the GCIP parameters (0.727) and the GCC parameters (0.720) showed no significant differences in their abilities to detect preperimetric glaucoma.
  
  
  CONCLUSIONS
  The capacity of Topcon 3D-OCT macular intraretinal parameters (GCIP and GCC measurements, not mNFL measurements) to diagnose preperimetric glaucoma is similar to that of the cpRNFL.
authors.affiliation: Department of Ophthalmology, Hanyang University College of Medicine, Guri Hospital, Guri, Gyeonggi, Korea.
authors.forename: Yu Jeong
authors.initials: YJ
authors.lastname: Kim
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Kang
authors.forename: Hee Yoon
authors.initials: HY
authors.lastname: Cho
authors.forename: Han Woong
authors.initials: HW
authors.lastname: Lim
authors.forename: Mincheol
authors.initials: M
authors.lastname: Seong
mesh_terms: D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006068:Gonioscopy; D064368:Healthy Volunteers; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D012372:ROC Curve; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000175:diagnosis; D058609:Visual Field Tests; D014794:Visual Fields