title: Treatment with a topical glucocorticoid, budesonide, reduced the variability of rhinomanometric nasal airway resistance.
abstract: Previous rhinomanometry studies have shown significant long-term variability of the nasal airway resistance and questioned the clinical validity of rhinomanometry.
  
  
  
  Could treatment with a topical glucocorticoid, budesonide, influence the long-term variability of active anterior rhinomanometry?
  
  
  
  Eight healthy volunteers participated in an unblinded controlled trial without, and later with, nasal budesonide once a day for 5 months. Their nasal airway resistance was measured every two weeks with active anterior rhinomanometry before and after decongestion with xylometazoline hydrochloride. In addition, subjective nasal obstruction was evaluated on a Visual Analogue Scale before each measurement. The participants had a year earlier been investigated with rhinomanometry every two weeks during 5 months but without budesonide treatment. We compared the variability of nasal airway resistance during the two periods with and without treatment with topical budesonide.
  
  
  
  Budesonide significantly reduced mean nasal airway resistance and the standard deviation of the mean after decongestion for 6 of 8 participants. The mean reduction of the nasal airway resistance was 40% for the decongested nasal cavity compared to the period without treatment with nasal budesonide. Subjective nasal obstruction assessed by Visual Analogue Scale was reduced in 3 of the 8 participants.
  
  
  
  The variability of nasal airway resistance was significantly reduced by treatment with topical budesonide for 6 out of 8 healthy volunteers participating in an unblinded repeated 5 month trial where the participants served as their own controls.
authors.forename: H L
authors.initials: HL
authors.lastname: Thulesius
authors.affiliation: Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Lund University, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Cervin
authors.forename: M
authors.initials: M
authors.lastname: Jessen
mesh_terms: D000403:Airway Resistance; D019819:Budesonide / Q000008:administration & dosage*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D009296:Nasal Cavity / Q000502:physiology*; D015508:Nasal Obstruction / Q000503:physiopathology*; D025363:Rhinomanometry / Q000379:methods*
chemical_list: D005938:Glucocorticoids; D007093:Imidazoles; D019819:Budesonide; C009695:xylometazoline