title: Pulmonary 2-deoxy-2-[(18)F]-fluoro-d-glucose uptake is low in treated patients with idiopathic pulmonary arterial hypertension.
abstract: Abstract Glucose metabolism measurement using 2-deoxy-2-[(18)F]-fluoro-d-glucose ((18)FDG) positron emission tomography (PET) could provide in vivo information about pulmonary vascular remodeling. The purpose of this study was to assess whether pulmonary (18)FDG uptake in idiopathic pulmonary arterial hypertension (IPAH) patients changes and, if so, to determine whether the change is related to disease severity and survival. Sixteen IPAH patients who were treated with IPAH-specific therapy and 7 patients who had a myocardial infarction (MI) without pulmonary hypertension were included. IPAH disease severity was determined using the 6-minute walk test and right heart catheterization 2 days before (18)FDG PET. Regions of interest were defined for left and right lungs, and standardized uptake values (SUVs), normalized to body weight, injected dose, and plasma glucose level, were derived. Mean SUVs for IPAH left and right lungs were [Formula: see text] and [Formula: see text] ([Formula: see text]), respectively. In MI patients, SUVs were [Formula: see text] and [Formula: see text] ([Formula: see text]) in left and right lungs, respectively. Total lung SUVs were similar in IPAH and MI patients ([Formula: see text] vs. [Formula: see text]; [Formula: see text]). There was no correlation between SUV and IPAH disease severity parameters. In addition, lung SUV did not predict survival in IPAH patients (hazard ratio, 1.155; 95% confidence interval, 0.16-8.26; [Formula: see text]). In conclusion, pulmonary (18)FDG uptake in treated IPAH patients is low and is not associated with disease severity and survival, thereby limiting its clinical use in patient care.
authors.affiliation: 1 Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Gerrina
authors.initials: G
authors.lastname: Ruiter
authors.forename: Yeun Ying
authors.initials: YY
authors.lastname: Wong
authors.forename: Pieter
authors.initials: P
authors.lastname: Raijmakers
authors.forename: Marc C
authors.initials: MC
authors.lastname: Huisman
authors.forename: Adriaan A
authors.initials: AA
authors.lastname: Lammertsma
authors.forename: Paul
authors.initials: P
authors.lastname: Knaapen
authors.forename: Frances S
authors.initials: FS
authors.lastname: de Man
authors.forename: Nico
authors.initials: N
authors.lastname: Westerhof
authors.forename: Willem J
authors.initials: WJ
authors.lastname: van der Laarse
authors.forename: Anton
authors.initials: A
authors.lastname: Vonk-Noordegraaf