title: Molecular mechanisms and biological role of Campylobacter jejuni attachment to host cells.
abstract: Adhesion to host cells is an important step in pathogenesis of Campylobacter jejuni, which is the most prevalent bacterial cause of human gastroenteritis worldwide. In contrast to other bacteria such as E. coli and Salmonella, adherence of C. jejuni is not mediated by fimbria or pili. A number of C. jejuni adhesion-related factors have been described. However, the results obtained by different researchers in different laboratories are often contradictory and inconclusive, with only some of the factors described being confirmed as true adhesins. In this review, we present the current state of studies on the mechanisms of attachment of C. jejuni to host cells.
authors.affiliation: School of Life Sciences, Faculty of Science, Engineering and Computing, Kingston University Penrhyn Road, Kingston-upon Thames, KT1 2EE UK.
authors.forename: S
authors.initials: S
authors.lastname: Rubinchik
authors.affiliation: School of Life Sciences, Faculty of Science, Engineering and Computing, Kingston University Penrhyn Road, Kingston-upon Thames, KT1 2EE UK.
authors.forename: A
authors.initials: A
authors.lastname: Seddon
authors.affiliation: School of Life Sciences, Faculty of Science, Engineering and Computing, Kingston University Penrhyn Road, Kingston-upon Thames, KT1 2EE UK.
authors.forename: A V
authors.initials: AV
authors.lastname: Karlyshev
keywords: Campylobacter jejuni; adhesins; adhesion; attachment; colonisation; evasion of immune response; glycoproteins; host cell receptors; pathogenesis