title: Anti-allergic rhinitis effect of caffeoylxanthiazonoside isolated from fruits of Xanthium strumarium L. in rodent animals.
abstract: The fruits of Xanthium strumarium L. (Asteraceae) have been used extensively in China for treatment of various diseases such as allergic rhinitis (AR), tympanitis, urticaria and arthritis or ozena. This study was designed to systemically investigate the effects of the caffeoylxanthiazonoside (CXT) isolated from fruits of X. strumarium on AR in rodent animals. Animals were orally administered with CXT. Anti-allergic activity of CXT was evaluated by passive cutaneous anaphylaxis test (PCA); acetic acid-induced writhing tests were used to evaluate the analgesic effects of CXT; acetic acid-induced vascular permeability tests were performed to evaluate anti-inflammatory effect of CXT. Then, the model AR in rats was established to evaluate the effects of CXT on AR with the following tests: the sneezing and nasal scratching frequencies, IgE level in serum, and histopathological examinations. Our results demonstrated that CXT had favorable anti-allergic, anti-inflammatory and analgesic effects. Additionally, we found that CXT was helpful to ameliorate the nasal symptoms and to down-regulate IgE levels in AR rats. Thus, we suggested that CXT can be treated as a candidate for treating AR.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China; Department of Pharmacology, College of Pharmacy, Third Military Medical University, Chongqing 400038, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
authors.forename: Qian-Liang
authors.initials: QL
authors.lastname: Ming
authors.affiliation: Center for Disease Control and Prevention, Jinan Military Region, PLA, 36 East Wenhua Road, Jinan 250014, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Han
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
authors.forename: Qiao-Yan
authors.initials: QY
authors.lastname: Zhang
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Jiang
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
authors.forename: Cheng-Jian
authors.initials: CJ
authors.lastname: Zheng
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China. Electronic address: than927@163.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Han
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China. Electronic address: qinsmmu@126.com.
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Qin
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002109:Caffeic Acids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D015536:Down-Regulation; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D005638:Fruit / Q000737:chemistry; D007073:Immunoglobulin E / Q000097:blood; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008813:Mice, Inbred ICR; D009666:Nose / Q000187:drug effects; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D008517:Phytotherapy; D017207:Rats, Sprague-Dawley; D065631:Rhinitis, Allergic / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D012912:Sneezing / Q000187:drug effects; D031210:Xanthium / Q000737:chemistry*
chemical_list: D000700:Analgesics; D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D002109:Caffeic Acids; D004365:Drugs, Chinese Herbal; C000594078:caffeoylxanthiazonoside; D007073:Immunoglobulin E; D019342:Acetic Acid
keywords: AR; Allergic rhinitis; Caffeoylxanthiazonoside; Fructus Xanthii; Xanthium strumarium L.