title: Ex-vivo lung perfusion.
abstract: This review outlines the new and promising technique of ex vivo lung perfusion and its clinical potential to increase the number of transplantable lungs and to improve the early and late outcome after transplantation. The rationale, the experimental background, the technique and protocols, and available devices for ex vivo lung perfusion are discussed. The current clinical experience worldwide and ongoing clinical trials are reviewed.
authors.affiliation: Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.|Laboratory for Experimental Thoracic Surgery, KU Leuven University, Leuven, Belgium.
authors.forename: Dirk
authors.initials: D
authors.lastname: Van Raemdonck
authors.affiliation: Laboratory for Experimental Thoracic Surgery, KU Leuven University, Leuven, Belgium.|Department of Anaesthesiology, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Arne
authors.initials: A
authors.lastname: Neyrinck
authors.affiliation: Division of Thoracic Surgery, Toronto General Hospital, Toronto, ON, Canada.|The Latner Thoracic Surgery Laboratories, Toronto General Research Institute, Toronto, ON, Canada.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Cypel
authors.affiliation: Division of Thoracic Surgery, Toronto General Hospital, Toronto, ON, Canada.|The Latner Thoracic Surgery Laboratories, Toronto General Research Institute, Toronto, ON, Canada.
authors.forename: Shaf
authors.initials: S
authors.lastname: Keshavjee
mesh_terms: D064591:Allografts; D000818:Animals; D002986:Clinical Trials as Topic; D004867:Equipment Design; D005112:Extracorporeal Circulation; D006801:Humans; D007249:Inflammation; D008168:Lung / Q000502:physiology*; D016040:Lung Transplantation / Q000295:instrumentation / Q000379:methods*; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion / Q000379:methods*; D013696:Temperature; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome
keywords: ex vivo lung perfusion; lung assessment; lung conditioning; lung preservation; lung repair; lung transplantation