title: Wounding the cornea to learn how it heals.
abstract: Corneal wound healing studies have a long history and rich literature that describes the data obtained over the past 70 years using many different species of animals and methods of injury. These studies have lead to reduced suffering and provided clues to treatments that are now helping patients live more productive lives. In spite of the progress made, further research is required since blindness and reduced quality of life due to corneal scarring still happens. The purpose of this review is to summarize what is known about different types of wound and animal models used to study corneal wound healing. The subject of corneal wound healing is broad and includes chemical and mechanical wound models. This review focuses on mechanical injury models involving debridement and keratectomy wounds to reflect the authors' expertise.
authors.affiliation: Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, Washington, DC 20037, USA; Department of Ophthalmology, The George Washington University Medical Center, Washington, DC 20037, USA. Electronic address: mastepp@gwu.edu.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Stepp
authors.affiliation: Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114-2500, USA.
authors.forename: James D
authors.initials: JD
authors.lastname: Zieske
authors.affiliation: Department of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
authors.forename: Vickery
authors.initials: V
authors.lastname: Trinkaus-Randall
authors.affiliation: Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, Washington, DC 20037, USA.
authors.forename: Briana M
authors.initials: BM
authors.lastname: Kyne
authors.affiliation: Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, Washington, DC 20037, USA.
authors.forename: Sonali
authors.initials: S
authors.lastname: Pal-Ghosh
authors.affiliation: Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, Washington, DC 20037, USA.
authors.forename: Gauri
authors.initials: G
authors.lastname: Tadvalkar
authors.affiliation: Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, Washington, DC 20037, USA.
authors.forename: Ahdeah
authors.initials: A
authors.lastname: Pajoohesh-Ganji
mesh_terms: D000818:Animals; D003315:Cornea / Q000601:surgery*; D065306:Corneal Injuries; D003646:Debridement; D004195:Disease Models, Animal; D051379:Mice; D009924:Organ Culture Techniques; D011817:Rabbits; D014945:Wound Healing / Q000502:physiology*
keywords: animal models; cornea; debridement; keratectomy; mouse strain; wound healing