title: Oral manifestations resulting from chemotherapy in children with acute lymphoblastic leukemia.
abstract: BACKGROUND
  Acute lymphocytic leukemia is a type of cancer most common in children and it is characterized by excessive and disordered immature leukocytes in the bone marrow.
  
  
  OBJECTIVE
  Identify most frequent oral manifestations in children with acute lymphocytic leukemia under chemotherapy treatment.
  
  
  METHODS
  The research was conducted on the electronic database PubMed/Medline, Science Direct, Scielo and Scopus. It has been sought papers with full presentation, wrote in Portuguese, English and Spanish, published between January 1992 and April 2013.
  
  
  RESULTS
  From studies primarily selected, only eight met the criteria of inclusion. All studies performed intraoral examinations to diagnose oral lesions. According to results, the most frequent lesions were mucositis, candidiasis, periodontitis and gingivitis. The oral health condition from acute lymphocytic leukemia carriers varied according oral hygiene of the patient.
  
  
  CONCLUSIONS
  The results of studies identified such a great part of patients with ALL presented some lesion in oral cavity during or after chemotherapy treatment. The dentist surgeon needs to recognize oral manifestations and intervene in the oral health of patients with ALL, contributing and helping with treatment.
authors.affiliation: Universidade Potiguar, NatalRN, Brasil, Odontologia, Universidade Potiguar, Natal, RN, Brasil.
authors.forename: Everton Freitas de
authors.initials: EF
authors.lastname: Morais
authors.affiliation: Universidade Potiguar, NatalRN, Brasil, Odontologia, Universidade Potiguar, Natal, RN, Brasil.
authors.forename: Jadson Alexandre da Silva
authors.initials: JA
authors.lastname: Lira
authors.affiliation: Universidade Potiguar, NatalRN, Brasil, Odontologia, Universidade Potiguar, Natal, RN, Brasil.
authors.forename: Rômulo Augusto de Paiva
authors.initials: RA
authors.lastname: Macedo
authors.affiliation: Universidade Potiguar, NatalRN, Brasil, Odontologia, Universidade Potiguar, Natal, RN, Brasil.
authors.forename: Klaus Steyllon dos
authors.initials: KS
authors.lastname: Santos
authors.affiliation: Liga Norte-Riograndense Contra o Câncer, NatalRN, Brasil, Liga Norte-Riograndense Contra o Câncer, Natal, RN, Brasil.
authors.forename: Cassandra Teixeira Valle
authors.initials: CT
authors.lastname: Elias
authors.affiliation: Universidade Potiguar, NatalRN, Brasil, Odontologia, Universidade Potiguar, Natal, RN, Brasil.
authors.forename: Maria de Lourdes Silva de Arruda
authors.initials: Mde L
authors.lastname: Morais
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D006801:Humans; D009059:Mouth Diseases / Q000139:chemically induced*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents