title: Loss of anti-hepatitis C virus antibodies following therapeutic sustained virological response in a HIV co-infected patient.
abstract: No data are available for the kinetics of anti-Hepatitis C Virus (HCV) antibodies in HIV/HCV co-infected patients after sustained virological response (SVR). We present a case of a HIV/HCV co-infected patient, showing a significant anti-HCV antibodies decrease during therapy, who achieved a HCV seroreversion 3 years after SVR. Among them, antibodies to core protein, the most strongly antigenic protein showed significant decrease. Our results indicate an absence of antigenic stimulation suggesting a total clearance of HCV.
authors.affiliation: Service de Microbiologie, University Paris Diderot, Hôpital Saint Louis, Paris, 75010 Paris, France. Electronic address: sarah.maylin@sls.aphp.fr.
authors.forename: Sarah
authors.initials: S
authors.lastname: Maylin
authors.affiliation: Service de Maladies Infectieuses, University Paris Diderot, Hôpital Saint Louis, 75010 Paris, France.
authors.forename: Nathalie Colin
authors.initials: NC
authors.lastname: de Verdière
authors.affiliation: Service de Microbiologie, University Paris Diderot, Hôpital Saint Louis, Paris, 75010 Paris, France.
authors.forename: Maud
authors.initials: M
authors.lastname: Salmona
authors.affiliation: Service de Microbiologie, University Paris Diderot, Hôpital Saint Louis, Paris, 75010 Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Simon
authors.affiliation: Service de Microbiologie, University Paris Diderot, Hôpital Saint Louis, Paris, 75010 Paris, France.
authors.forename: Constance
authors.initials: C
authors.lastname: Delaugerre
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D006526:Hepatitis C / Q000188:drug therapy / Q000276:immunology* / Q000821:virology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D018937:Hepatitis C Antibodies
keywords: Clearance; HCV; HIV; SVR; anti-HCV antibodies