title: Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves of Trichilia emetica and Opilia amentacea in an Animal Model of Type 2 Diabetes Mellitus.
abstract: Trichilia emetica and Opilia amentacea traditional Burkinabe medicinal plants were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of type 2 diabetes. In vitro and in vivo antioxidant and antihypertensive potential and antilipidemia and antihyperglycemia activities in an animal model of type 2 diabetes mellitus have been studied. The antioxidant activity of the flavonoids from leaves of Trichilia emetica and Opilia amentacea has been evaluated using β -carotene-linoleic acid system, 1,1-diphenyl-2-picrylhydrazyl inhibitory activity, chelation of iron (II) ions, and lipid peroxidation which showed more pronounced antioxidant capacities of Trichilia emetica. Total cholesterol concentrations decreased in an animal model of type 2 diabetes mellitus under effects of flavonoid-rich fractions from leaves of Trichilia emetica and Opilia amentacea has been observed. Extract of flavonoid-rich fractions from Trichilia emetica shown maximum radical scavenging activity and possessed marked antiamylase activity which may be due to the presence of certain secondary metabolites. Suggested better antihyperglycemia, antilipidemia, and antihypertensive properties of flavonoid-rich fractions from Trichilia emetica compared to the extract of Opilia amentacea are demonstrating antidiabetic potential of Trichilia emetica as therapeutic targets for the management of type 2 diabetes.
authors.affiliation: Unit of Formation in Sciences Applied and Technological (UFR/SAT) and Institute of Sciences of the Environment and the Rural Development (ISEDR), Polytechnic University of Dédougou, Burkina Faso ; Laboratory of Biochemistry and Applied Chemistry, University of Ouagadougou, 09 P.O. Box 848, Ouagadougou 09, Burkina Faso.
authors.forename: Kiessoun
authors.initials: K
authors.lastname: Konaté
authors.affiliation: Laboratory of Animal Physiology, UFR Bioscience, University of Felix Houphouet Boigny of Abidjan, 22 P.O. Box 582, Abidjan 22, Cote D'Ivoire.
authors.forename: Kassi
authors.initials: K
authors.lastname: Yomalan
authors.affiliation: Department of Plant Physiology and Ecology, Taras Shevchenko National University of Kyiv, Volodymyrs'ka Street 64, Kyiv 01601, Ukraine.
authors.forename: Oksana
authors.initials: O
authors.lastname: Sytar
authors.affiliation: Laboratory of Plant Ecology and Biology, University of Ouagadougou, 09 P.O. Box 848, Ouagadougou 09, Burkina Faso.
authors.forename: Patrice
authors.initials: P
authors.lastname: Zerbo
authors.affiliation: Department of Plant Physiology, Slovak Agriculture University in Nitra, A. Hlinku 2, 94976 Nitra, Slovakia.
authors.forename: Marian
authors.identifier: 0000-0002-6597-7838
authors.initials: M
authors.lastname: Brestic
authors.affiliation: Laboratory of Tropical and Subtropical Agronomy and Ethnobotany, Department of Plants Production, Faculty of Biosciences Ingineering, Gent University, Belgium.
authors.forename: Van Damme
authors.initials: VD
authors.lastname: Patrick
authors.affiliation: Institute of Genetics, University of Bucharest, 060101 Bucharest, Romania.
authors.forename: Paul
authors.initials: P
authors.lastname: Gagniuc
authors.affiliation: Laboratory of Biochemistry and Molecular Genetics Microbial, University of Ouagadougou, 03 P.O. Box 7131, Ouagadougou 03, Burkina Faso.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Barro