title: Evaluation of the acaricidal toxicities of camphor and its structural analogues against house dust mites by the impregnated fabric disc method.
abstract: BACKGROUND
  The acaricidal activities of (±)-camphor structural analogues against house dust mites were evaluated using the impregnated fabric disc bioassay.
  
  
  RESULTS
  The acaricidal effects of camphor and its structural analogues were evaluated against Dermatophagoides farinae and D. pteronyssinus. Based on the LD50 values against D. farinae, (±)-camphor (0.95 µg cm(-2) ) was 38.75 times more effective than N,N-diethyl-m-toluamide (DEET) (36.81 µg cm(-2) ), followed by (+)-camphor (1.41 µg cm(-2) ), (-)-camphor (2.03 µg cm(-2) ) and (1R)-camphor oxime (3.31 µg cm(-2) ) in the impregnated fabric disc bioassay. However, camphor-10-sulfonic acid and camphoric acid had no observable activity against D. farinae or D. pteronyssinus. The acaricidal activities of camphor and its structural analogues against D. pteronyssinus were similar to those against D. farinae.
  
  
  CONCLUSIONS
  These results indicate that camphor and its structural analogues are suitable for producing acaricidal agents against house dust mites.
authors.affiliation: Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology, College of Agriculture and Life Sciences, Chonbuk National University, Jeonju, Republic of Korea.
authors.forename: Ju-Hyun
authors.initials: JH
authors.lastname: Jeon
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Yang
authors.forename: Hoi-Seon
authors.initials: HS
authors.lastname: Lee
mesh_terms: D056810:Acaricides / Q000633:toxicity*; D000818:Animals; D002164:Camphor / Q000031:analogs & derivatives / Q000633:toxicity*; D040001:Dermatophagoides farinae / Q000187:drug effects*; D040002:Dermatophagoides pteronyssinus / Q000187:drug effects*; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D013329:Structure-Activity Relationship
chemical_list: D056810:Acaricides; D002164:Camphor
keywords: Dermatophagoides farinae; Dermatophagoides pteronyssinus; acaricidal agent; acaricidal effect; camphor; structural analogues