title: Detection of theophylline utilising portable electrochemical sensors.
abstract: The electrochemical oxidation of theophylline (TP) is investigated utilising screen-printed electrodes. Through thorough investigation of pH, we propose a reaction mechanism, finding that the oxidation of TP is stable over a wide pH range, in particular under acidic conditions. Conversely under alkaline conditions, theophylline fouls the electrode surface. The screen-printed carbon sensors are applied towards the electroanalytical sensing of TP with a remarkable amount of success in aqueous solution at physiological pH. The screen-printed sensors have been shown to be applicable to the detection of TP at unharmful, medicinally relevant (55-110 μM), and toxic concentrations in aqueous media at physiological pH. Thus this work presents a proof-of-concept approach towards TP detection utilising sensors commonly implemented in point-of-care applications.
authors.affiliation: Faculty of Science and Engineering, School of Chemistry and the Environment, Division of Chemistry and Environmental Science, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, Lancs, UK. c.banks@mmu.ac.uk.
authors.forename: Tiancheng
authors.initials: T
authors.lastname: Wang
authors.forename: Edward P
authors.initials: EP
authors.lastname: Randviir
authors.forename: Craig E
authors.initials: CE
authors.lastname: Banks
mesh_terms: D055664:Electrochemical Techniques / Q000295:instrumentation*; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D013806:Theophylline / Q000032:analysis*
chemical_list: D013806:Theophylline