title: [Stevens-Johnson syndrome - a case report].
abstract: Stevens-Johnson syndrome (SJS) is a severe skin and mucosal condition, with eruption of hemorrhagic vesiculous to bullous lesions, caused by hypersensitive reaction to certain drugs; rarely, it can be parainfectious. SJS is a minor form of toxic epidermal necrolysis, with involvement of less than 10 % of the skin surface. Cutaneous and mucosal lesions are caused by necrosis of epithelial cells induced by T lymphocytes. The diagnosis is based on clinical features but it has to be confirmed by histologic and immunohistologic examination of the lesions. The treatment consists of high doses of systemic corticosteroids and particularly thorough local, supportive and symptomatic therapy. The authors present a case of parainfectious SJS and discuss the latest knowledge about SJS as well as therapeutic options.
authors.affiliation: Department of Otorhinolaryngology, University Hospital Ostrava, Ostrava, Czech Republic, e-mail: lenka.cabalova@fno.cz.
authors.forename: L
authors.initials: L
authors.lastname: Čábalová
authors.forename: K
authors.initials: K
authors.lastname: Zeleník
authors.forename: P
authors.initials: P
authors.lastname: Komínek
mesh_terms: D006801:Humans; D013262:Stevens-Johnson Syndrome