title: The challenge of drug development in acute heart failure: balancing mechanisms, targeting patients, and gambling on outcomes.
authors.affiliation: Department of Emergency Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Pang
authors.affiliation: Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: mgivertz@partners.org.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Givertz
mesh_terms: D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008297:Male; D054832:Urocortins / Q000008:administration & dosage*
chemical_list: D054832:Urocortins
keywords: acute heart failure; hemodynamics; neurohormone; randomized controlled trial; urocortin-2