title: Randomized clinical trial comparing reduced-volume oral picosulfate and a prepackaged low-residue diet with 4-liter PEG solution for bowel preparation.
abstract: BACKGROUND
  Reduced-volume bowel preparation with a low-residue diet prior to colonoscopy would result in better patient compliance and sufficient bowel preparation.
  
  
  OBJECTIVE
  To compare the clinical efficacy of reduced-volume sodium picosulfate and a prepackaged low-residue diet with that of the standard bowel preparation using 4 L of PEG solution.
  
  
  METHODS
  Prospective, single center, single blind, active control, randomized study (NCCCTS-12-619, KCT0000470).
  
  
  METHODS
  Ambulatory outpatient clinic at the National Cancer Center, Republic of Korea.
  
  
  METHODS
  A total of 194 subjects were randomly assigned for this study, 97 in each group. After exclusions, 94 subjects in the Picolight group and 90 in the PEG group completed the study and were analyzed.
  
  
  METHODS
  Sodium picosulfate with a prepackaged low-residue, one-day diet or 4-L PEG for bowel preparation.
  
  
  METHODS
  Success rate of the bowel preparation, tolerability, adverse events, cecal intubation time, polyp detection rate and adenoma detection rate.
  
  
  RESULTS
  The bowel preparation success rate was significantly higher (91.5% vs. 81.1%, p = 0.04) and the rates of adverse events, including abdominal distension, pain, nausea, vomiting and abdominal discomfort, were significantly lower in the picosulfate group than the PEG group. Cecal intubation times and the polyp and adenoma detection rates were similar in the 2 groups.
  
  
  CONCLUSIONS
  Single center, limited population, all colonoscopies were performed in the morning.
  
  
  CONCLUSIONS
  Bowel preparation with low-volume oral picosulfate and a prepackaged low-residue diet enhances colon cleansing and is better tolerated than the standard bowel preparation.
authors.affiliation: 1Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea 2Biometric Research Branch, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea.
authors.forename: Yong Sok
authors.initials: YS
authors.lastname: Kim
authors.forename: Chang Won
authors.initials: CW
authors.lastname: Hong
authors.forename: Byung Chang
authors.initials: BC
authors.lastname: Kim
authors.forename: Kyung Su
authors.initials: KS
authors.lastname: Han
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Park
authors.forename: Hyo
authors.initials: H
authors.lastname: Seong Choi
authors.forename: Jungnam
authors.initials: J
authors.lastname: Joo
authors.forename: Dae Kyung
authors.initials: DK
authors.lastname: Sohn
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects; D002951:Citrates / Q000008:administration & dosage / Q000009:adverse effects; D003113:Colonoscopy; D004032:Diet; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000009:adverse effects; D017063:Outcome Assessment, Health Care; D010349:Patient Compliance; D010847:Picolines / Q000008:administration & dosage / Q000009:adverse effects; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000009:adverse effects; D011446:Prospective Studies; D016037:Single-Blind Method
chemical_list: D002400:Cathartics; D002951:Citrates; D009942:Organometallic Compounds; D010847:Picolines; D011092:Polyethylene Glycols; C005701:picosulfate sodium