title: Three solid malignancies and a myelodysplastic syndrome with a protracted course after kidney transplantation.
abstract: Although a well-known complication after transplantation, multiple non-skin malignancies within a patient are rare. We report on a kidney transplant recipient who over the course of 20 years developed breast cancer twice, a uroepithelial carcinoma, and myelodysplasia transforming into acute leukaemia. Breast cancer was treated as usual. The transitional cell carcinoma was managed with partial cyst ureterectomy with transposition of the native ureter to the graft. Withdrawal of immunosuppression followed under a "watchful waiting" regime. In conclusion, alertness is requested regarding development of malignancies. Creative solutions are necessary in the management of such patients. Under exceptional circumstances, withdrawal of immunosuppression may be an option.
authors.affiliation: 4th Department of Internal Medicine (Nephrology and Haematology/Oncology) , Klinikum Wels-Grieskirchen , Wels , Austria.
authors.forename: Friedrich C
authors.initials: FC
authors.lastname: Prischl
authors.affiliation: 4th Department of Internal Medicine (Nephrology and Haematology/Oncology) , Klinikum Wels-Grieskirchen , Wels , Austria.
authors.forename: Sonja
authors.initials: S
authors.lastname: Burgstaller
authors.affiliation: 4th Department of Internal Medicine (Nephrology and Haematology/Oncology) , Klinikum Wels-Grieskirchen , Wels , Austria.
authors.forename: Manfred
authors.initials: M
authors.lastname: Wallner
authors.affiliation: 4th Department of Internal Medicine (Nephrology and Haematology/Oncology) , Klinikum Wels-Grieskirchen , Wels , Austria.
authors.forename: Eva
authors.initials: E
authors.lastname: Seiringer
authors.affiliation: 4th Department of Internal Medicine (Nephrology and Haematology/Oncology) , Klinikum Wels-Grieskirchen , Wels , Austria.
authors.forename: Patrick
authors.initials: P
authors.lastname: Dinkhauser
authors.affiliation: Department of Urology , Klinikum Wels-Grieskirchen , Wels , Austria.
authors.forename: Walter
authors.initials: W
authors.lastname: Pauer
authors.affiliation: 4th Department of Internal Medicine (Nephrology and Haematology/Oncology) , Klinikum Wels-Grieskirchen , Wels , Austria.
authors.forename: Josef
authors.initials: J
authors.lastname: Thaler
keywords: breast cancer; kidney transplantation; leukaemia; malignancy; transitional cell carcinoma