title: Profile of idiopathic parkinson's disease in Moroccan patients.
abstract: OBJECTIVE
  To characterize clinical aspects of Idiopathic Parkinson's disease from a movement disorders consultation in University Hospital of Rabat.
  
  
  METHODS
  Retrospective review of medical records of 117 patients with diagnosis of Idiopathic Parkinson's disease seen in our outpatient clinic from 2006 to 2011.
  
  
  RESULTS
  Mean age was 64 ± 10 years with predominance of men (61.5%). Mean age at disease onset was 57 ± 11 years. Early onset Parkinson's Disease was recorded in 12.8%. The median duration of disease was 5 years. Initial symptom appeared on the right side in 56.5%. Tremor presentation was the most frequent (40.2%). Symptom severity was mild to moderate in 80% of cases (UPDRS < 30). Forty four per cent of patients were receiving both Dopamine Agonists and Levodopa and in 69% of cases Levodopa was introduced within the first year following onset. The mean Levodopa Equivalent Doses (LED) was 667 ± 446 mg/day. Motor complications were found in 42% with motor fluctuations in 28.7% and 2dyskinesias in 26.7%. Non motor complications are represented mainly by autonomic disorders (44%). There were no differences in the clinical presentation related to the age at onset. Age of onset < 45 and LED > 600 mg are identified as risk factors for motor fluctuations whereas duration of Levodopa treatment is a risk factor of dyskinesias.
  
  
  CONCLUSIONS
  Our patients are younger compared to most series with high prevalence of early onset forms. In the majority of cases, Levodopa was introduced within the first year following onset which expose patients to dyskinesias early in the course of the disease.
authors.affiliation: Department of Neurology B and Neurogenetics, Hôpital des Spécialités O.N.O, 6444 Rabat, Morocco.|University Mohamed V Souissi, Angle avenue Allal El Fassi et Mfadel Cherkaoui, Al Irfane, Rabat, Morocco.
authors.forename: Wafa
authors.initials: W
authors.lastname: Regragui
authors.affiliation: Department of Neurology B and Neurogenetics, Hôpital des Spécialités O.N.O, 6444 Rabat, Morocco.|University Mohamed V Souissi, Angle avenue Allal El Fassi et Mfadel Cherkaoui, Al Irfane, Rabat, Morocco.
authors.forename: Lamiae
authors.initials: L
authors.lastname: Lachhab
authors.affiliation: Laboratory of biostatistics, clinical research and epidemiology, Faculty of medicine and pharmacy of Rabat, Rabat, Morocco.|Department of Public Health, Faculty of medicine and pharmacy of Rabat, Rabat, Morocco.|University Mohamed V Souissi, Angle avenue Allal El Fassi et Mfadel Cherkaoui, Al Irfane, Rabat, Morocco.
authors.forename: Rachid
authors.initials: R
authors.lastname: Razine
authors.affiliation: Department of Neurology B and Neurogenetics, Hôpital des Spécialités O.N.O, 6444 Rabat, Morocco.|University Mohamed V Souissi, Angle avenue Allal El Fassi et Mfadel Cherkaoui, Al Irfane, Rabat, Morocco.
authors.forename: Leila
authors.initials: L
authors.lastname: Raissouni
authors.affiliation: Department of Neurology B and Neurogenetics, Hôpital des Spécialités O.N.O, 6444 Rabat, Morocco.|University Mohamed V Souissi, Angle avenue Allal El Fassi et Mfadel Cherkaoui, Al Irfane, Rabat, Morocco.
authors.forename: Khaoula
authors.initials: K
authors.lastname: Rasmouni
authors.affiliation: Department of Neurology B and Neurogenetics, Hôpital des Spécialités O.N.O, 6444 Rabat, Morocco.|University Mohamed V Souissi, Angle avenue Allal El Fassi et Mfadel Cherkaoui, Al Irfane, Rabat, Morocco.
authors.forename: Fatima
authors.initials: F
authors.lastname: Imounan
authors.affiliation: Department of Neurology B and Neurogenetics, Hôpital des Spécialités O.N.O, 6444 Rabat, Morocco.|University Mohamed V Souissi, Angle avenue Allal El Fassi et Mfadel Cherkaoui, Al Irfane, Rabat, Morocco.
authors.forename: El Hachmia Ait
authors.initials: EHA
authors.lastname: Benhaddou
authors.affiliation: Laboratory of biostatistics, clinical research and epidemiology, Faculty of medicine and pharmacy of Rabat, Rabat, Morocco.|University Mohamed V Souissi, Angle avenue Allal El Fassi et Mfadel Cherkaoui, Al Irfane, Rabat, Morocco.
authors.forename: Redouane
authors.initials: R
authors.lastname: Abouqal
authors.affiliation: Department of Neurology B and Neurogenetics, Hôpital des Spécialités O.N.O, 6444 Rabat, Morocco.|Centre de recherche en épidémiologie clinique et essais thérapeutiques Faculty of medicine and pharmacy of Rabat, Rabat, Morocco.|University Mohamed V Souissi, Angle avenue Allal El Fassi et Mfadel Cherkaoui, Al Irfane, Rabat, Morocco.
authors.forename: Ali
authors.initials: A
authors.lastname: Benomar
authors.affiliation: Department of Neurology B and Neurogenetics, Hôpital des Spécialités O.N.O, 6444 Rabat, Morocco.|University Mohamed V Souissi, Angle avenue Allal El Fassi et Mfadel Cherkaoui, Al Irfane, Rabat, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Yahyaoui