title: Development of enterovirus 71 vaccines: from the lab bench to Phase III clinical trials.
abstract: The widespread epidemics of enterovirus 71 (EV71) seriously affected the Western Pacific Region. Young children, especially those younger than 3 years are the most susceptible population to the EV71-associated diseases. Several Asian countries have begun to focus on the research and development of EV71 vaccines. Five inactivated whole-virus EV71 candidate vaccines (three were manufactured in mainland China based on a C4 genotype strain, one in Taiwan based on a B4 genotype strain and one in Singapore based on a B2 genotype strain) have been assessed in clinical trials. Three candidate vaccines developed in mainland China have already completed Phase III clinical trials recently. The tested EV71 vaccine could provide good efficacy, satisfactory safety, and high immunogenicity. Thus, inactivated EV71 vaccines are expected to become the first available vaccines against EV71 in the near future.
authors.affiliation: College of Pharmacy, Third Military Medical University and National Engineering Research Center for Immunological Products, Chongqing, PR China.
authors.forename: Jing-Xin
authors.initials: JX
authors.lastname: Li
authors.forename: Qun-Ying
authors.initials: QY
authors.lastname: Mao
authors.forename: Zheng-Lun
authors.initials: ZL
authors.lastname: Liang
authors.forename: Hong
authors.initials: H
authors.lastname: Ji
authors.forename: Feng-Cai
authors.initials: FC
authors.lastname: Zhu
mesh_terms: D000818:Animals; D017326:Clinical Trials, Phase III as Topic / Q000379:methods / Q000639:trends*; D029821:Enterovirus A, Human / Q000187:drug effects* / Q000502:physiology; D004769:Enterovirus Infections / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D015164:Vaccines, Inactivated / Q000008:administration & dosage*; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D015164:Vaccines, Inactivated; D014765:Viral Vaccines