title: Adult T-cell leukemia-lymphoma associated with follicular mucinosis.
abstract: Follicular mucinosis is frequently associated with follicular mycosis fungoides, but its association with adult T-cell leukemia-lymphoma (ATLL) is extremely rare. We report a case of a 50-year-old female patient with a history of ATLL, after multiple treatments, with residual/recurrent skin tumors in the forehead and legs. Biopsy of a skin tumor from the forehead revealed a perifollicular and intrafollicular atypical lymphoid infiltrate with abundant mucin deposition. Immunohistochemical stains showed that the atypical cells were positive for CD3, CD4, and CD25. Reverse transcription polymerase chain reaction performed on the tissue sections confirmed the presence of human T-cell leukemia virus in the biopsies of skin tumors. To our knowledge, this is only the third reported case of a follicular mucinosis in the setting of ATLL.
authors.affiliation: *Laboratory of Pathology, and †Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
authors.forename: Leomar Y
authors.initials: LY
authors.lastname: Ballester
authors.forename: Edward W
authors.initials: EW
authors.lastname: Cowen
authors.forename: Chyi-Chia Richard
authors.initials: CC
authors.lastname: Lee
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D059248:Chemoradiotherapy; D004279:DNA, Viral / Q000235:genetics; D015480:Deltaretrovirus Antibodies / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000378:metabolism / Q000473:pathology* / Q000628:therapy / Q000821:virology; D008875:Middle Aged; D000507:Mucinosis, Follicular / Q000378:metabolism / Q000473:pathology*; D011237:Predictive Value of Tests; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy / Q000821:virology; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D004279:DNA, Viral; D015480:Deltaretrovirus Antibodies