title: Evaluation of Effects of Intraperitoneal CO2 Pressure in Laparoscopic Operations on Kidney, Pancreas, Liver and Spleen in Dogs.
abstract: BACKGROUND
  During laparoscopy, insufflation of an inert gas in the peritoneal cavity creates a working space to facilitate surgery. The space should be large enough to facilitate surgery without increasing intra-abdominal pressure (IAP) over a threshold limit (usually 15 mm Hg).
  
  
  OBJECTIVE
  This experimental study was performed to evaluate the effects of increasing in intra-abdominal pressure on internal organs.
  
  
  METHODS
  Twenty female mixed breed dogs (20 ± 3 kg, 18 ± 1.2 months) were selected. They were randomly divided to two groups (n = 10). The intra-abdominal pressure was maintained 12 mm Hg and 20 mm Hg during the operation in control group and in test group respectively.
  
  
  RESULTS
  Histopathologic evaluations revealed more pathological changes at the kidney of all the dogs in test group in comparison to control group.
  
  
  CONCLUSIONS
  Our findings revealed that organs that their blood supplies are related to one single or two arteries and their blood drainage are related to one or two veins are more sensitive to increased intra-abdominal pressure.
authors.affiliation: Department of Animal Science, Agriculture Faculty, Islamic Azad University, Khorramabad Branch, Khorramabad, IR Iran.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Hejazi
authors.affiliation: Department of Clinical Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, IR Iran.
authors.forename: Mir Sepehr
authors.initials: MS
authors.lastname: Pedram
authors.affiliation: Laparoscopy Training Center, Tehran University of Medical Science Tehran, IR Iran.
authors.forename: Hosein
authors.initials: H
authors.lastname: Ashegh
authors.affiliation: Department of Clinical Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, IR Iran.
authors.forename: Nazanin
authors.initials: N
authors.lastname: Jafari
authors.affiliation: Department of Clinical Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, IR Iran.
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Ghazisaeedi
authors.affiliation: Department of Clinical Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, IR Iran.
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Abdi
keywords: Kidney; Laparoscopy; Liver; Pancreas; Pneumoperitoneum; Spleen