title: The inflammasomes in autoinflammatory diseases with skin involvement.
abstract: During the past years, significant progress in the understanding of the complexity, regulation, and relevance of innate immune responses underlying several inflammatory conditions with neutrophilic skin involvement has been made. These diseases belong to the novel class of autoinflammatory diseases, and several are caused by mutations in genes regulating the function of innate immune complexes, termed inflammasomes, leading to enhanced secretion of the proinflammatory cytokine IL-1β. Consequently, targeting of IL-1β has proven successful in the treatment of these diseases, and the identification of related pathogenic mechanisms in other more common skin diseases characterized by autoinflammation and neutrophilic tissue damage also provides extended opportunities for therapy by interfering with IL-1 signaling.
authors.affiliation: Department of Dermatology, Zürich University Hospital, Zürich, Switzerland.
authors.forename: Hans-Dietmar
authors.initials: HD
authors.lastname: Beer
authors.affiliation: Department of Dermatology, Zürich University Hospital, Zürich, Switzerland.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Contassot
authors.affiliation: Department of Dermatology, Zürich University Hospital, Zürich, Switzerland. Electronic address: lars.french@usz.ch.
authors.forename: Lars E
authors.initials: LE
authors.lastname: French
mesh_terms: D000152:Acne Vulgaris / Q000235:genetics / Q000276:immunology / Q000628:therapy; D020083:Acquired Hyperostosis Syndrome / Q000235:genetics / Q000276:immunology / Q000628:therapy; D000818:Animals; D001170:Arthritis, Infectious / Q000235:genetics / Q000276:immunology / Q000628:therapy; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D001691:Biological Therapy; D006801:Humans; D058847:Inflammasomes / Q000235:genetics / Q000276:immunology*; D015603:Keratinocytes / Q000276:immunology*; D051379:Mice; D017511:Pyoderma Gangrenosum / Q000235:genetics / Q000276:immunology / Q000628:therapy; D019873:Schnitzler Syndrome / Q000235:genetics / Q000276:immunology / Q000628:therapy; D012871:Skin Diseases / Q000235:genetics / Q000276:immunology* / Q000628:therapy
chemical_list: D058847:Inflammasomes