title: Vitamin D3 mediated effects on postprandial leukocyte activation and arterial stiffness in men and women.
abstract: Postprandial inflammation is considered to be pro-atherogenic. Vitamin D can reduce inflammation and arterial stiffness. We hypothesized that vitamin D3 improves postprandial arterial elasticity by the modulation of leukocyte activation. Healthy volunteers underwent two oral fat-loading tests (OFLTs). The augmentation index (AIx) and flow cytometric quantification of leukocyte activation markers were measured. After the first OFLT, 100 000 IU of vitamin D3 was administered and a second OFLT was carried out 7 days later. Six men and six women were included. A favorable reduction in AIx was found after vitamin D3 supplementation (P=0.042) in both genders. After vitamin D3, exclusively in women a reduction in the area under the postprandial curve for monocytes CD11b and CD35 by 10.5% (P=0.016) and 12.5% (P=0.04) and neutrophil CD11b by 17.0% (P=0.014) was observed. In conclusion, vitamin D3 probably increased postprandial arterial elasticity in men and women, but reduced postprandial leukocyte activation exclusively in women.
authors.affiliation: Department of Internal Medicine, Sint Franciscus Gasthius, Rotterdam, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: Klop
authors.affiliation: Department of Clinical Chemistry, Sint Franciscus Gasthius, Rotterdam, The Netherlands.
authors.forename: G-J M
authors.initials: GJ
authors.lastname: van de Geijn
authors.affiliation: Department of Statistics and Education, Sint Franciscus Gasthius, Rotterdam, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Birnie
authors.affiliation: Department of Clinical Chemistry, Sint Franciscus Gasthius, Rotterdam, The Netherlands.
authors.forename: T L
authors.initials: TL
authors.lastname: Njo
authors.affiliation: Department of Clinical Chemistry, Sint Franciscus Gasthius, Rotterdam, The Netherlands.
authors.forename: H W
authors.initials: HW
authors.lastname: Janssen
authors.affiliation: Department of Clinical Pharmacy, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: H G
authors.initials: HG
authors.lastname: Jansen
authors.affiliation: 1] Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands [2] Interuniversity Cardiology Institute of The Netherlands (ICIN), Utrecht, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Jukema
authors.affiliation: Department of Internal Medicine, Sint Franciscus Gasthius, Rotterdam, The Netherlands.
authors.forename: J W F
authors.initials: JW
authors.lastname: Elte
authors.affiliation: Department of Internal Medicine, Sint Franciscus Gasthius, Rotterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Castro Cabezas
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D039481:CD11b Antigen / Q000235:genetics / Q000378:metabolism; D018955:CD36 Antigens / Q000235:genetics / Q000378:metabolism; D002762:Cholecalciferol / Q000008:administration & dosage*; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000187:drug effects*; D017463:Receptors, Complement 3b / Q000235:genetics / Q000378:metabolism; D059289:Vascular Stiffness / Q000187:drug effects*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D039481:CD11b Antigen; D018955:CD36 Antigens; C509991:CR1 protein, human; C509295:ITGAM protein, human; D017463:Receptors, Complement 3b; D002762:Cholecalciferol