title: Blending lecithin and gelatin improves the formation of thymol nanodispersions.
abstract: Delivery systems of lipophilic antimicrobials such as thymol prepared with generally recognized-as-safe ingredients are needed to enhance the microbiological safety of low-acid (pH > 4.6) foods. Nanodispersions with particle diameters below 100 nm are particularly demanded because of the low turbidity and physical stability. In this study, thymol dispersions were prepared by gelatin and soy lecithin on an individual basis or in combination. Dispersions prepared with the lecithin-gelatin blend were translucent and stable at pH 5.0-8.0, contrasting with turbid and unstable dispersions when the emulsifiers were used individually. The synergistic surface activity of gelatin and lecithin was due to complex formation that effectively prevented particle size change due to coalescence and Ostwald ripening. Electrostatic interactions were observed to be the colloidal force responsible for preventing particle aggregation. The studied generally recognized-as-safe nanodispersions have great potential to deliver lipophilic antimicrobials such as thymol in low-acid foods to enhance food safety.
authors.affiliation: Department of Food Science and Technology, University of Tennessee , Knoxville, Tennessee 37996, United States.
authors.forename: Jia
authors.initials: J
authors.lastname: Xue
authors.forename: Qixin
authors.initials: Q
authors.lastname: Zhong
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000295:instrumentation*; D005780:Gelatin / Q000737:chemistry*; D054709:Lecithins / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013943:Thymol / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D004337:Drug Carriers; D054709:Lecithins; D013943:Thymol; D005780:Gelatin