title: [Prospects of using miramistin for individual prevention of sexual HIV transmission].
abstract: For more than 20 years cationic surfactant Miramistin has been used in Russia and Ukraine as an antiseptic mean for individual prophylaxis of venereal diseases and for the treatment of genitourinary tract and other systems infections. Complete inhibition of HIV-1 activity in vitro by Miramistin in concentrations higher than 0.0075%, has been demonstrated, that allows to consider this detergent as a potent first-generation vaginal microbicide for the prevention of HIV transmission. Higher anti-HIV effect of Miramistin than of nonoxynol-9 and low local toxicity show good prospects of using Miramistin for individual prevention of HIV transmission.
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Krivorutchenko
authors.forename: I B
authors.initials: IB
authors.lastname: Andronovskaia
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001548:Benzalkonium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission*; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D019169:Jurkat Cells; D008297:Male; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D001548:Benzalkonium Compounds; C058048:miramistin