title: Vitamin D receptor gene polymorphism and left ventricular hypertrophy in chronic kidney disease.
abstract: FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated with LVH in ESRD patients, we addressed this study in patients with chronic kidney disease (CKD) not yet on dialysis. One hundred and forty five patients with CKD stage 3 were genotyped for FokI and BsmI VDR polymorphisms, in order to assess the relationships between these VDR polymorphisms, some markers of mineral bone disorders, and LVH measured by echocardiography. Patients bearing either the Ff heterozygous or FF homozygous genotype had significantly higher PTH values than those bearing the ff genotype. The relationships between VDR genotypes and LVH revealed a highly significant association of the BsmI Bb heterozygous genotype with LVH. In patients with CKD stage 3 BsmI B allele was independently related to LVH. Since LVH is a frequent finding in dialysis population due to several mechanisms, the presence of the same relationship in patients with CKD strengthens the hypothesis that alterations of vitamin D signaling are implicated in LVH development in patients with renal diseases.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, Messina 98123, Italy. dsantoro@unime.it.
authors.forename: Domenico
authors.initials: D
authors.lastname: Santoro
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, Messina 98123, Italy. giorgiagagliostro@tiscali.it.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Gagliostro
authors.affiliation: Department of Economical, Business and Environmental Sciences and Quantitative Methods, University of Messina, Messina 98123, Italy. aalibrandi@unime.it.
authors.forename: Angela
authors.initials: A
authors.lastname: Alibrandi
authors.affiliation: Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina 98123, Italy. riccardo.ientile@unime.it.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ientile
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, Messina 98123, Italy. gbellinghieri@unime.it.
authors.forename: Guido
authors.initials: G
authors.lastname: Bellinghieri
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, Messina 98123, Italy. visavica@tin.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Savica
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, Messina 98123, Italy. buemim@unime.it.
authors.forename: Michele
authors.initials: M
authors.lastname: Buemi
authors.affiliation: Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina 98123, Italy. dcaccamo@unime.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Caccamo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000235:genetics*; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D018167:Receptors, Calcitriol