title: Reversible functional connectivity disturbances during transient global amnesia.
abstract: OBJECTIVE
  Transient global amnesia (TGA), an abrupt occurrence of severe anterograde episodic amnesia accompanied by repetitive questioning, has been known for more than 50 years. Despite extensive research, there is no clear evidence for the underlying pathophysiological basis of TGA. Moreover, there is no neuroimaging method to evaluate TGA in real time.
  
  
  METHODS
  Here we used resting-state functional magnetic resonance imaging recorded in 12 patients during the acute phase of TGA together with connectivity and cluster analyses to detect changes in the episodic memory network in TGA.
  
  
  RESULTS
  Our results show a significant reduction in functional connectivity of the episodic memory network during TGA, which is more pronounced in the hyperacute phase than in the postacute phase. This disturbance is bilateral, and reversible after recovery. Although the hippocampus and its connections are significantly impaired, other parts of the episodic memory network are also impaired. Similar results were obtained for the analysis of the episodic memory network whether it was defined in a data-driven or literature-based manner.
  
  
  CONCLUSIONS
  These results suggest that TGA is related to a functional disturbance in the episodic memory network, and supply a neuroimaging correlate of TGA during the acute phase.
authors.affiliation: Department of Neurology, Hadassah Hebrew University Medical School, Jerusalem, Israel; Faculty of Medicine, Hadassah Hebrew University Medical School, Jerusalem, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Peer
authors.forename: Mor
authors.initials: M
authors.lastname: Nitzan
authors.forename: Ilan
authors.initials: I
authors.lastname: Goldberg
authors.forename: Judith
authors.initials: J
authors.lastname: Katz
authors.forename: J Moshe
authors.initials: JM
authors.lastname: Gomori
authors.forename: Tamir
authors.initials: T
authors.lastname: Ben-Hur
authors.forename: Shahar
authors.initials: S
authors.lastname: Arzy
mesh_terms: D000368:Aged; D020236:Amnesia, Transient Global / Q000175:diagnosis* / Q000503:physiopathology*; D016000:Cluster Analysis; D005260:Female; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology*; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology
keywords: Amnesia; Memory; Resting-state; fMRI