title: Dispersive solid-phase extraction based on magnetic dummy molecularly imprinted microspheres for selective screening of phthalates in plastic bottled beverages.
abstract: A new magnetic dummy molecularly imprinted dispersive solid-phase extraction (MAG-MIM-dSPE) coupled with gas chromatography-FID was developed for selective determination of phthalates in plastic bottled beverages. The new magnetic dummy molecularly imprinted microspheres (MAG-MIM) using diisononyl phthalate as a template mimic were synthesized by coprecipitation coupled with aqueous suspension polymerization and were successfully applied as the adsorbents for MAG-MIM-dSPE to extract and isolate five phthalates from plastic bottled beverages. Validation experiments showed that the MAG-MIM-dSPE method had good linearity at 0.0040-0.40 μg/mL (0.9991-0.9998), good precision (3.1-6.9%), and high recovery (89.5-101.3%), and limits of detection were obtained in a range of 0.53-1.2 μg/L. The presented MAG-MIM-dSPE method combines the quick separation of magnetic particles, special selectivity of MIM, and high extraction efficiency of dSPE, which could potentially be applied to selective screening of phthalates in beverage products.
authors.affiliation: Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education & Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Hebei University , Baoding, 071002, China.
authors.forename: Jindong
authors.initials: J
authors.lastname: Qiao
authors.forename: Mingyu
authors.initials: M
authors.lastname: Wang
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Yan
authors.forename: Gengliang
authors.initials: G
authors.lastname: Yang
mesh_terms: D000327:Adsorption; D001628:Beverages / Q000032:analysis*; D002849:Chromatography, Gas; D005506:Food Contamination / Q000032:analysis; D008280:Magnetics; D008863:Microspheres; D054802:Molecular Imprinting; D010795:Phthalic Acids / Q000032:analysis / Q000302:isolation & purification*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000295:instrumentation / Q000379:methods*
chemical_list: D010795:Phthalic Acids; D011108:Polymers; C032279:phthalic acid