title: Dual imaging-guided photothermal/photodynamic therapy using micelles.
abstract: We report a type of photosensitizer (PS)-loaded micelles integrating cyanine dye as potential theranostic micelles for precise anatomical tumor localization via dual photoacoustic (PA)/near-infrared fluorescent (NIRF) imaging modalities, and simultaneously superior cancer therapy via sequential synergistic photothermal therapy (PTT)/photodynamic therapy (PDT). The micelles exhibit enhanced photostability, cell internalization and tumor accumulation. The dual NIRF/PA imaging modalities of the micelles cause the high imaging contrast and spatial resolution of tumors, which provide precise anatomical localization of the tumor and its inner vasculature for guiding PTT/PDT treatments. Moreover, the micelles can generate severe photothermal damage on cancer cells and destabilization of the lysosomes upon PTT photoirradiation, which subsequently facilitate synergistic photodynamic injury via PS under PDT treatment. The sequential treatments of PTT/PDT trigger the enhanced cytoplasmic delivery of PS, which contributes to the synergistic anticancer efficacy of PS. Our strategy provides a dual-modal cancer imaging with high imaging contrast and spatial resolution, and subsequent therapeutic synergy of PTT/PDT for potential multimodal theranostic application.
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Guo
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: Huajian
authors.initials: H
authors.lastname: Mao
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Zhu
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: Hui
authors.initials: H
authors.lastname: He
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: School for Radiological & Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou 215123, China; School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
authors.forename: Yangyun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School for Radiological & Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou 215123, China; School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tian
authors.affiliation: School for Radiological & Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou 215123, China; School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
authors.forename: Cuicui
authors.initials: C
authors.lastname: Ge
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
authors.forename: Qiaoli
authors.initials: Q
authors.lastname: Peng
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Xiangliang
authors.initials: X
authors.lastname: Yang
authors.affiliation: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, United States.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China. Electronic address: gangliu.cmitm@xmu.edu.cn.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China; School for Radiological & Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou 215123, China; School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China. Electronic address: chenhb@suda.edu.cn.
authors.forename: Huabing
authors.initials: H
authors.lastname: Chen
mesh_terms: D000818:Animals; D002232:Carbocyanines / Q000008:administration & dosage / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004396:Coloring Agents; D005260:Female; D006046:Gold; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008823:Micelles; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D061848:Optical Imaging / Q000379:methods; D061088:Photoacoustic Techniques / Q000379:methods; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D002232:Carbocyanines; D004396:Coloring Agents; D008823:Micelles; D017319:Photosensitizing Agents; D006046:Gold
keywords: Micelles; Near infrared fluorescent imaging; Photoacoustic imaging; Photodynamic therapy; Photosensitizer; Photothermal therapy