title: Compressed sensing based virtual-detector photoacoustic microscopy in vivo.
abstract: Photoacoustic microscopy (PAM) is becoming a vital tool for various biomedical studies, including functional and molecular imaging of cancer. However, due to the use of a focused ultrasonic transducer for photoacoustic detection, the image quality of conventional PAM degrades rapidly away from the ultrasonic focal zone. To improve the image quality of PAM for out-of-focus regions, we have developed compressed sensing based virtual-detector photoacoustic microscopy (CS-PAM). Through phantom and in vivo experiments, it has been demonstrated that CS-PAM can effectively extend the depth of focus of PAM, and thus may greatly expand its potential biomedical applications.
authors.affiliation: Qufu Normal University, College of Computer Science, 80 Yantai Road North, Rizhao 276826, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Meng
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 1068 Xueyuan Boulevard, Shenzhen 518055, China.
authors.forename: Chengbo
authors.initials: C
authors.lastname: Liu
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 1068 Xueyuan Boulevard, Shenzhen 518055, China.
authors.forename: Jiaxiang
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 1068 Xueyuan Boulevard, Shenzhen 518055, China.
authors.forename: Riqiang
authors.initials: R
authors.lastname: Lin
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 1068 Xueyuan Boulevard, Shenzhen 518055, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Song
mesh_terms: D000818:Animals; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D051379:Mice; D008819:Mice, Nude; D008853:Microscopy / Q000379:methods*; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods*