title: Topological regulation of lipid balance in cells.
abstract: Lipids are unevenly distributed within and between cell membranes, thus defining organelle identity. Such distribution relies on local metabolic branches and mechanisms that move lipids. These processes are regulated by feedback mechanisms that decipher topographical information in organelle membranes and then regulate lipid levels or flows. In the endoplasmic reticulum, the major lipid source, transcriptional regulators and enzymes sense changes in membrane features to modulate lipid production. At the Golgi apparatus, lipid-synthesizing, lipid-flippase, and lipid-transport proteins (LTPs) collaborate to control lipid balance and distribution within the membrane to guarantee remodeling processes crucial for vesicular trafficking. Open questions exist regarding LTPs, which are thought to be lipid sensors that regulate lipid synthesis or carriers that transfer lipids between organelles across long distances or in contact sites. A novel model is that LTPs, by exchanging two different lipids, exploit one lipid gradient between two distinct membranes to build a second lipid gradient.
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia-Antipolis and CNRS, 06560 Valbonne, France; email: drin@ipmc.cnrs.fr.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Drin
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D025461:Feedback, Physiological; D005658:Fungi / Q000502:physiology; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D008055:Lipids / Q000737:chemistry*; D015388:Organelles / Q000378:metabolism; D010743:Phospholipids / Q000737:chemistry; D015398:Signal Transduction; D013261:Sterols / Q000737:chemistry; D021601:trans-Golgi Network / Q000737:chemistry
chemical_list: D008055:Lipids; D010743:Phospholipids; D013261:Sterols
keywords: lipid synthesis; lipid-transport proteins; membrane contact sites; membrane identity; phosphatidylinositol phosphate; sterol