title: Cancer immunoinformatics: a new assistant tool for malignant disease research.
abstract: OBJECTIVE
  To introduce the recent developments in cancer immunoinformatics with an emphasis on the latest trends and future direction.
  
  
  METHODS
  All related articles in this review were searched from PubMed published in English from 1992 to 2013. The search terms were cancer, immunoinformatics, immunological databases, and computational vaccinology.
  
  
  METHODS
  Original articles and reviews those were related to application of cancer immunoinformatics about tumor basic and clinical research were selected.
  
  
  RESULTS
  Cancer immunoinformatics has been widely researched and applied in a series of fields of cancer research, including computational tools for cancer, cancer immunological databases, computational vaccinology, and cancer diagnostic workflows. Furthermore, the improvement of its theory and technology brings an enlightening insight into understanding and researching cancer and helps expound more deep and complete mechanisms of tumorigenesis and progression.
  
  
  CONCLUSIONS
  Cancer immunoinformatics provides promising methods and novel strategies for the discovery and development of tumor basic and clinical research.
authors.affiliation: Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China.
authors.forename: Weijia
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China. Email: tjzhangrp@gmail.com.
authors.forename: Rupeng
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China.
authors.forename: Han
authors.initials: H
authors.lastname: Liang
authors.affiliation: Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Cancer Prevention Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China.
authors.forename: Fangxuan
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China.
authors.forename: Jinpu
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China.
authors.forename: Xiubao
authors.initials: X
authors.lastname: Ren
mesh_terms: D019496:Cancer Vaccines / Q000627:therapeutic use; D019295:Computational Biology / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000517:prevention & control
chemical_list: D019496:Cancer Vaccines