title: Aquagenic keratoderma. Two new case reports and a new hypothesis.
abstract: Aquagenic keratoderma has been described as a transient condition affecting predominantly young females and defined clinically by the appearance of palmar hyper-wrinkling accentuated after immersion in water. We present two new cases with aquagenic palmoplantar acrokeratoderma - a child and a young male. A significant clinical improvement was achieved after topical treatment with aluminum salts. Aquagenic palmar keratoderma may be a clue to cystic fibrosis in adolescents and young adults. We developed a new hypothesis on its pathogenesis.
authors.affiliation: Department of Dermatology and Venerology, Saint Kliment Ohridski University, University Hospital Lozenetz, Bulgaria.
authors.forename: Georgi
authors.initials: G
authors.lastname: Tchernev
authors.affiliation: Department of Dermatology and Venerology, Medical University Sofia, Sofia, Bulgaria.
authors.forename: Kristina
authors.initials: K
authors.lastname: Semkova
authors.affiliation: Department of Dermatology, University Hospital of Coimbra, Coimbra, Portugal.
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Cardoso
authors.affiliation: Department of General and Clinical Pathology, Medical Faculty, Trakia University, Stara Zagora, Bulgaria.
authors.forename: J Julian
authors.initials: JJ
authors.lastname: Ananiev
authors.affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital, Dresden-Friedrichstadt, Dresden, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Wollina
keywords: Aquagenic keratoderma; cystic fibrosis; gene association; sympathetic small fibres; treatment