title: Lipo-poly(L-histidine) hybrid materials with pH-sensitivity, intracellular delivery efficiency, and intrinsic targetability to cancer cells.
abstract: Biocompatible lipo-histidine hybrid materials conjugated with IR820 dye show pH-sensitivity, efficient intracellular delivery of doxorubicin (Dox), and intrinsic targetability to cancer cells. These new materials form highly uniform Dox-loaded nanosized vesicles via a self-assembly process showing good stability under physiological conditions. The Dox-loaded micelles are effective for suppressing MCF-7 tumors, as demonstrated in vitro and in vivo. The combined mechanisms of the EPR effect, active internalization, endosomal-triggered release, and drug escape from endosomes, and a long blood circulation time, clearly prove that the IR820 lipopeptide DDS is a safe theranostic agent for imaging-guided cancer therapy.
authors.affiliation: BK 21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, Pusan National University, Pusan, 609-735, Republic of Korea.
authors.forename: Renjith P
authors.initials: RP
authors.lastname: Johnson
authors.forename: Young-Il
authors.initials: YI
authors.lastname: Jeong
authors.forename: Johnson V
authors.initials: JV
authors.lastname: John
authors.forename: Chung-Wook
authors.initials: CW
authors.lastname: Chung
authors.forename: Seon Hee
authors.initials: SH
authors.lastname: Choi
authors.forename: Song Yi
authors.initials: SY
authors.lastname: Song
authors.forename: Dae Hwan
authors.initials: DH
authors.lastname: Kang
authors.forename: Hongsuk
authors.initials: H
authors.lastname: Suh
authors.forename: Il
authors.initials: I
authors.lastname: Kim
mesh_terms: D006639:Histidine / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D061986:MCF-7 Cells; D046529:Microscopy, Electron, Transmission
chemical_list: C033223:polyhistidine; D006639:Histidine
keywords: anti-cancer; lipopeptides; nanobiotechnology; poly(L-histidine); targeted drug delivery systems