title: ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children.
abstract: We identified ATF7IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B-ALL) and showed that B-ALL with ATF7IP/PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B-ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup.
authors.affiliation: Department of Paediatric Haematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Mitsui
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ichikawa
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakabayashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Matsuoka
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kojima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Iijima
authors.forename: Kaori
authors.initials: K
authors.lastname: Ootsubo
authors.forename: Keisuke
authors.initials: K
authors.lastname: Oboki
authors.forename: Hajime
authors.initials: H
authors.lastname: Okita
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yasuda
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Hata
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Yoshida
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Kiyokawa
authors.forename: Akira
authors.initials: A
authors.lastname: Ohara
mesh_terms: D001483:Base Sequence; D002648:Child; D056905:Chromosome Breakpoints; D016000:Cluster Analysis; D020869:Gene Expression Profiling; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics*; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000235:genetics*; D012097:Repressor Proteins; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C501309:ATF7IP protein, human; D015514:Oncogene Proteins, Fusion; D012097:Repressor Proteins; D014157:Transcription Factors; D020797:Receptor, Platelet-Derived Growth Factor beta
keywords: ATF7IP; PDGFRB; Ph-like; acute lymphoblastic leukaemia; screening