title: Risk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies: analysis of the control arm of PATRICIA.
abstract: BACKGROUND
  We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681).
  
  
  METHODS
  Using Poisson regression, we compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15-25 years) in the control arm (DNA negative at baseline for the corresponding HPV type [HPV-16: n = 8193; HPV-18: n = 8463]).
  
  
  RESULTS
  High titers of naturally acquired HPV-16 antibodies and/or linear trend for increasing antibody levels were significantly associated with lower risk of incident and persistent infection, atypical squamous cells of undetermined significance or greater (ASCUS+), and cervical intraepithelial neoplasia grades 1/2 or greater (CIN1+, CIN2+). For HPV-18, although seropositivity was associated with lower risk of ASCUS+ and CIN1+, no association between naturally acquired antibodies and infection was demonstrated. Naturally acquired HPV-16 antibody levels of 371 (95% confidence interval [CI], 242-794), 204 (95% CI, 129-480), and 480 (95% CI, 250-5756) EU/mL were associated with 90% reduction of incident infection, 6-month persistent infection, and ASCUS+, respectively.
  
  
  CONCLUSIONS
  Naturally acquired antibodies to HPV-16, and to a lesser extent HPV-18, are associated with some reduced risk of subsequent infection and cervical abnormalities associated with the same HPV type.
authors.affiliation: Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia, IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Catalonia, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Castellsagué
authors.affiliation: Department of Gynecology and Obstetrics, Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Brazil.
authors.forename: Paulo
authors.initials: P
authors.lastname: Naud
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan.
authors.forename: Song-Nan
authors.initials: SN
authors.lastname: Chow
authors.affiliation: Department of Pathology and Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque.
authors.forename: Cosette M
authors.initials: CM
authors.lastname: Wheeler
authors.affiliation: Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippine General Hospital, Manila, The Philippines.
authors.forename: Maria Julieta V
authors.initials: MJ
authors.lastname: Germar
authors.affiliation: University of Tampere, School of Public Health, Tampere.
authors.forename: Matti
authors.initials: M
authors.lastname: Lehtinen
authors.affiliation: Department of Obstetrics and Gynaecology, University of Helsinki, Finland.
authors.forename: Jorma
authors.initials: J
authors.lastname: Paavonen
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Unnop
authors.initials: U
authors.lastname: Jaisamrarn
authors.affiliation: Department of Microbiology and Infectious Diseases, The Royal Women's Hospital Department of Microbiology, The Royal Children's Hospital, Parkville/Murdoch Childrens Research Institute Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Garland
authors.affiliation: Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Morelos, Mexico.
authors.forename: Jorge
authors.initials: J
authors.lastname: Salmerón
authors.affiliation: Family Federation of Finland, Sexual Health Clinic, Helsinki, Finland.
authors.forename: Dan
authors.initials: D
authors.lastname: Apter
authors.affiliation: Manchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, St Mary's Hospital, Manchester, United Kingdom.
authors.forename: Henry
authors.initials: H
authors.lastname: Kitchener
authors.affiliation: Departamento de Tocoginecologia da Unicamp, University of Campinas, Sao Paulo, Brazil.
authors.forename: Julio C
authors.initials: JC
authors.lastname: Teixeira
authors.affiliation: Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, Western Australia Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead, Sydney, New South Wales, Australia.
authors.forename: S Rachel
authors.initials: SR
authors.lastname: Skinner
authors.affiliation: College of Medicine, University of the Philippines, Philippine General Hospital, Makati Medical Centre, Makati City, The Philippines.
authors.forename: Genara
authors.initials: G
authors.lastname: Limson
authors.affiliation: Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, United Kingdom.
authors.forename: Anne
authors.initials: A
authors.lastname: Szarewski
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
authors.forename: Barbara
authors.initials: B
authors.lastname: Romanowski
authors.affiliation: Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
authors.forename: Fred Y
authors.initials: FY
authors.lastname: Aoki
authors.affiliation: Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Germany.
authors.forename: Tino F
authors.initials: TF
authors.lastname: Schwarz
authors.affiliation: Department of Gynaecology, University Hospital KU Leuven Gasthuisberg, Belgium.
authors.forename: Willy A J
authors.initials: WA
authors.lastname: Poppe
authors.affiliation: Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia, IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Catalonia, Spain Network on Cooperative Cancer Research, RTICC, Catalonia, Spain.
authors.forename: F Xavier
authors.initials: FX
authors.lastname: Bosch
authors.affiliation: Department of Gynecology and Obstetrics, Federal University of Paraná, Infectious Diseases in Gynecology and Obstetrics Sector, Curitiba, Brazil.
authors.forename: Newton S
authors.initials: NS
authors.lastname: de Carvalho
authors.affiliation: Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Peters
authors.affiliation: Multidisciplinary Breast Clinic-Gynecologic Oncology, Antwerp University Hospital, University of Antwerp, Belgium.
authors.forename: Wiebren A A
authors.initials: WA
authors.lastname: Tjalma
authors.affiliation: Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, Rockville, Maryland.
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Safaeian
authors.affiliation: 4Clinics, Paris, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Raillard
authors.affiliation: GlaxoSmithKline Vaccines, Wavre, Belgium.
authors.forename: Dominique
authors.initials: D
authors.lastname: Descamps
authors.affiliation: GlaxoSmithKline Vaccines, Wavre, Belgium.
authors.forename: Frank
authors.initials: F
authors.lastname: Struyf
authors.affiliation: GlaxoSmithKline Vaccines, King of Prussia, Pennsylvania.
authors.forename: Gary
authors.initials: G
authors.lastname: Dubin
authors.affiliation: GlaxoSmithKline Vaccines, Wavre, Belgium.
authors.forename: Dominique
authors.initials: D
authors.lastname: Rosillon
authors.affiliation: GlaxoSmithKline Vaccines, Wavre, Belgium.
authors.forename: Laurence
authors.initials: L
authors.lastname: Baril
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology*; D004279:DNA, Viral / Q000235:genetics; D004311:Double-Blind Method; D005260:Female; D052162:Human papillomavirus 16 / Q000235:genetics / Q000276:immunology*; D052161:Human papillomavirus 18 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology*; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000821:virology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral
keywords: HPV; cervical abnormality; infection; naturally acquired antibodies; risk reduction