title: Detrimental effects of secondhand smoke exposure on infants with cystic fibrosis.
abstract: BACKGROUND
  Secondhand smoke (SHS) has deleterious respiratory, immune, and nutritional effects in children, but there is little data regarding the effects of SHS exposure in infants with cystic fibrosis (CF).
  
  
  METHODS
  A retrospective chart review was undertaken from 2008 to 2012 of 75 infants with CF. Growth, lung function, Chest CT imaging, and microbiologic characteristics were compared between 4 and 12 months for SHS and non-SHS exposed patients.
  
  
  RESULTS
  SHS exposed infants with CF had decreased growth between 4 and 12 months compared to non-SHS exposed infants. SHS exposure was associated with increased bronchodilator responsiveness and air trapping, but no other lung function or radiologic differences. SHS exposure was also associated with increased methicillin resistant Staphylococcus aureus (MRSA) and anaerobic growth on respiratory culture. There was no difference in Pseudomonas aeruginosa between groups. There were no differences in antibiotic use or hospitalizations between the groups.
  
  
  CONCLUSIONS
  SHS exposure in CF infants is associated with diminished growth, increased air trapping and bronchodilator responsiveness, and propensity to culture MRSA and facultative anaerobic bacteria, suggesting the need for early, aggressive parental smoking cessation interventions to prevent SHS exposure complications.
authors.affiliation: Section of Pediatric Pulmonology, Nationwide Children's Hospital, Columbus, Ohio; Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
authors.forename: Benjamin T
authors.initials: BT
authors.lastname: Kopp
authors.forename: Lisa
authors.initials: L
authors.lastname: Sarzynski
authors.forename: Sabrina
authors.initials: S
authors.lastname: Khalfoun
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
authors.forename: Rohan
authors.initials: R
authors.lastname: Thompson
authors.forename: Lisa
authors.initials: L
authors.lastname: Nicholson
authors.forename: Frederick
authors.initials: F
authors.lastname: Long
authors.forename: Robert
authors.initials: R
authors.lastname: Castile
authors.forename: Judith
authors.initials: J
authors.lastname: Groner
mesh_terms: D000388:Air; D001993:Bronchodilator Agents / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology; D004361:Drug Tolerance; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D007223:Infant; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D011859:Radiography; D012189:Retrospective Studies; D013183:Sputum / Q000382:microbiology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D001993:Bronchodilator Agents; D014028:Tobacco Smoke Pollution
keywords: nutrition; pulmonary function testing, MRSA; tobacco