title: Investigating tissue respiration and skin microhaemocirculation under adaptive changes and the synchronization of blood flow and oxygen saturation rhythms.
abstract: Multi-functional laser non-invasive diagnostic systems allow the study of a number of microcirculatory parameters, including index of blood microcirculation (Im) (by laser Doppler flowmetry, LDF) and oxygen saturation (StO2) of skin tissue (by tissue reflectance oximetry, TRO). This research aimed to use such a system to investigate the synchronization of microvascular blood flow and oxygen saturation rhythms under normal and adaptive change conditions. Studies were conducted on eight healthy volunteers of 21-49 years. These volunteers were observed between one and six months, totalling 422 basic tests (3 min each). Measurements were performed on the palmar surface of the right middle finger and the lower forearm's medial surface. Rhythmic oscillations of LDF and TRO were studied using wavelet analysis. Combined tissue oxygen consumption data for all volunteers during 'adaptive changes' increased relative to normal conditions with and without arteriovenous anastomoses. Data analysis revealed resonance and synchronized rhythms in microvascular blood flow and oxygen saturation as an adaptive change in myogenic oscillation (vasomotion) resulting from exercise and possibly psychoemotional stress. Synchronization of myogenic rhythms during adaptive changes may lead to increased oxygen consumption as a result of increased microvascular blood flow velocity.
authors.affiliation: Photonics and Nanoscience Group, Division of Physics, School of Engineering, Physics and Mathematics, University of Dundee, Dundee DD1 4HN, UK. State University-Education-Science-Production Complex, Scientific-Educational Center of 'Biomedical Engineering', Oryol 302020, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Dunaev
authors.forename: V V
authors.initials: VV
authors.lastname: Sidorov
authors.forename: A I
authors.initials: AI
authors.lastname: Krupatkin
authors.forename: I E
authors.initials: IE
authors.lastname: Rafailov
authors.forename: S G
authors.initials: SG
authors.lastname: Palmer
authors.forename: N A
authors.initials: NA
authors.lastname: Stewart
authors.forename: S G
authors.initials: SG
authors.lastname: Sokolovski
authors.forename: E U
authors.initials: EU
authors.lastname: Rafailov
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D001163:Arteriovenous Anastomosis / Q000502:physiology; D019069:Cell Respiration; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D010092:Oximetry; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D010477:Perfusion; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply*; D055815:Young Adult
chemical_list: D010100:Oxygen