title: Cisplatin induced paroxysmal supraventricular tachycardia.
abstract: Cisplatin or cis-diamminedichloroplatinum (CDDP) is the first member of a class of platinum-containing anti-cancer drugs that act by binding to and causing cross-linking of deoxyribonucleic acid, which ultimately triggers apoptosis. Cisplatin has a broad-spectrum antineoplastic activity against various types of human tumors. Unfortunately, the optimal usefulness of Cisplatin is limited secondary to its dose related toxicity especially nephrotoxicity. Cisplatin chemotherapy is also associated with cardiotoxic effects that may range from silent arrhythmias to heart failure and even sudden cardiac death. These effects are more pronounced when cisplatin is combined with other cardiotoxic drugs. Here, we report a case of patient of cancer lung who developed paroxysmal supraventricular tachycardia following administration of Cisplatin. A brief review of the literature follows.
authors.affiliation: Department of Medical Oncology, Sheri Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Waseem
authors.initials: W
authors.lastname: Raja
authors.affiliation: Department of Medical Oncology, Sheri Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: M Hussain
authors.initials: MH
authors.lastname: Mir
authors.affiliation: Department of Medical Oncology, Sheri Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Imtiyaz
authors.initials: I
authors.lastname: Dar
authors.affiliation: Department of Medical Oncology, Sheri Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Muzamil Ahmad
authors.initials: MA
authors.lastname: Banday
authors.affiliation: Department of Cardiology, Sheri Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Irfan
authors.initials: I
authors.lastname: Ahmad
keywords: Cisplatin; lung cancer; paroxysmal supraventricular tachycardia