title: Evaluation of the outcome benefit conferred by intensive surveillance strategies in women with early-stage endometrial cancer.
abstract: BACKGROUND
  The optimum follow-up regimen after treatment for early-stage endometrial cancer with curative intent is unknown. The National Comprehensive Cancer Network recommends a physical exam and vaginal cytology every three to six months for two years then at six to 12 month intervals with annual chest X-rays (CXR). However, there is debate as to whether intensive follow-up results in an improvement in outcomes for those with recurrent endometrial cancer.
  
  
  OBJECTIVE
  To determine if intensive surveillance for recurrent cancer in women with early-stage endometrial cancer improves their outcomes.
  
  
  METHODS
  The Roswell Park Cancer Institute tumor registry was used to identify patients with Stage I and II endometrial cancer initially diagnosed and treated over an 18-year period, who subsequently recurred. Clinico-pathological variables were abstracted. Patients were divided into two groups, depending on their mode of diagnosis of recurrent cancer: 1) routine screening, or 2) symptomatic. The outcomes between the two groups were compared.
  
  
  RESULTS
  Fifty-two patients met inclusion criteria. Twenty-three patients were diagnosed via routine screening methods and 29 were symptomatic at presentation. Groups were equally represented with respect to age, stage, grade, adjuvant therapy, site of recurrence (local, distant), and time to recurrence (p > 0.05). Median survival time was 79 months for those diagnosed during routine screening and 80 months for symptomatic patients (p > 0.05).
  
  
  CONCLUSIONS
  Pap smear and CXR appear to be of limited utility as the present study has shown that women diagnosed as a result of intensive surveillance did not have a better outcome than those who presented when symptomatic.
authors.affiliation: Department of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Kiran
authors.affiliation: Division of Gynecologic Oncology, Penn State Hershey Medical Center Hershey, PA, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Kesterson
authors.affiliation: Division of Gynecologic Oncology, Uludag University, Bursa, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Ozerkan
authors.affiliation: Mount Sinai Medical Center Department of Obstetrics and Gynecology, New York, NY, USA.
authors.forename: M
authors.initials: M
authors.lastname: Kanis
authors.affiliation: Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: A
authors.initials: A
authors.lastname: Groman
authors.affiliation: Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: S
authors.initials: S
authors.lastname: Lele
mesh_terms: D000368:Aged; D058070:Asymptomatic Diseases; D018572:Disease-Free Survival; D055088:Early Detection of Cancer; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology; D009367:Neoplasm Staging; D011159:Population Surveillance; D013902:Radiography, Thoracic; D013997:Time Factors; D014626:Vaginal Smears