title: Role of prolactin in B cell regulation in multiple sclerosis.
abstract: The role of prolactin in MS pathogenesis was investigated. Prolactin levels were higher in MS subjects both during remission and exacerbation compared to control subjects. Prolactin increased JAK2 expression and Stat phosphorylation on B cells, up-regulated anti-MOG antibody secreting cell numbers, BAFF levels, and Bcl-2expression, and down-regulated expression of Trp63. Prolactin levels correlated positively with anti-MOG secreting cell numbers, and negatively with induced apoptotic B cells. Additionally, prolactin decreased B cell receptor-mediated activation threshold, and induced CD40 expression in B cells. These findings suggest that prolactin promotes B cell autoreactivity in MS through different mechanisms.
authors.affiliation: Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea, FLENI, Buenos Aires, Argentina. Electronic address: jcorreale@fleni.org.ar.
authors.forename: Jorge
authors.initials: J
authors.lastname: Correale
authors.affiliation: Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea, FLENI, Buenos Aires, Argentina.
authors.forename: Mauricio F
authors.initials: MF
authors.lastname: Farez
authors.affiliation: Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea, FLENI, Buenos Aires, Argentina.
authors.forename: María Célica
authors.initials: MC
authors.lastname: Ysrraelit
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000175:diagnosis; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000175:diagnosis*; D011388:Prolactin / Q000097:blood / Q000502:physiology*
chemical_list: D015415:Biomarkers; D011388:Prolactin
keywords: Autoimmunity; B cells; Hormones; Multiple sclerosis; Prolactin