title: [Hepatotoxicity of cytostatic drugs in treatment of oncology patients].
abstract: A hepatotoxicity can be observed at the use of different groups of antitumoral drugs. Cytotoxicity drugs have a leading place in relation to incidence and severity of liver damage. During chemotherapy the development of hepatotoxicity is caused by thedamage of the liver parenchymal cells with fatty degeneration, necrosis of the liver tissue, and cholestasis. The study of the mechanisms of development, clinical course and laboratory manifestations of hepatotoxicity of chemotherapy will lead to its prevention or reduction, which will improve the immediate and long-term results of treatment of patients with cancer.
authors.forename: L A
authors.initials: LA
authors.lastname: Syvak
authors.forename: S A
authors.initials: SA
authors.lastname: Lial'kin
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Klimanov
authors.forename: H O
authors.initials: HO
authors.lastname: Hubareva
authors.forename: A V
authors.initials: AV
authors.lastname: Askol's'kyĭ
authors.forename: N V
authors.initials: NV
authors.lastname: Kasap
authors.forename: N M
authors.initials: NM
authors.lastname: Maĭdanevych
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D054697:Cytostatic Agents / Q000627:therapeutic use / Q000633:toxicity*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D054697:Cytostatic Agents