title: Netamines H-N, tricyclic alkaloids from the marine sponge Biemna laboutei and their antimalarial activity.
abstract: Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 μM.
authors.affiliation: Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, Faculté des Sciences et Technologies, University of Reunion Island , 15 Avenue René Cassin, CS 92003, 97744 Saint-Denis Cedex 9, La Réunion, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Gros
authors.forename: Ali
authors.initials: A
authors.lastname: Al-Mourabit
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Martin
authors.forename: Jonathan
authors.initials: J
authors.lastname: Sorres
authors.forename: Jean
authors.initials: J
authors.lastname: Vacelet
authors.forename: Michel
authors.initials: M
authors.lastname: Frederich
authors.forename: Maurice
authors.initials: M
authors.lastname: Aknin
authors.forename: Yoel
authors.initials: Y
authors.lastname: Kashman
authors.forename: Anne
authors.initials: A
authors.lastname: Gauvin-Bialecki
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008270:Madagascar; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects*; D011161:Porifera / Q000737:chemistry*; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D011799:Quinazolines; C000589755:netamine K