title: Peliosis hepatis complicated by portal hypertension following renal transplantation.
abstract: Peliosis hepatis (PH) is a vascular lesion of the liver that mimics a hepatic tumor. PH is often associated with underlying conditions, such as chronic infection and tumor malignancies, or with the use of anabolic steroids, immunosuppressive drugs, and oral contraceptives. Most patients with PH are asymptomatic, but some present with abdominal distension and pain. In some cases, PH may induce intraperitoneal hemorrhage and portal hypertension. This study analyzed a 46-year-old male who received a transplanted kidney nine years prior and had undergone long-term immunosuppressive therapy following the renal transplantation. The patient experienced progressive abdominal distention and pain in the six months prior to this study. Initially, imaging studies revealed multiple liver tumor-like abnormalities, which were determined to be PH by pathological analysis. Because the hepatic lesions were progressively enlarged, the patient suffered from complications related to portal hypertension, such as intense ascites and esophageal varices bleeding. Although the patient was scheduled to undergo liver transplantation, he suffered hepatic failure and died prior to availability of a donor organ.
authors.affiliation: Chia-Ying Yu, Li-Wei Chen, Tsung-Shih Lee, Rong-Nan Chien, Department of Gastroenterology, Chang Gung Memorial Hospital and University at Keelung, Keelung 20401, Taiwan.
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Yu
authors.affiliation: Chia-Ying Yu, Li-Wei Chen, Tsung-Shih Lee, Rong-Nan Chien, Department of Gastroenterology, Chang Gung Memorial Hospital and University at Keelung, Keelung 20401, Taiwan.
authors.forename: Liang-Che
authors.initials: LC
authors.lastname: Chang
authors.affiliation: Chia-Ying Yu, Li-Wei Chen, Tsung-Shih Lee, Rong-Nan Chien, Department of Gastroenterology, Chang Gung Memorial Hospital and University at Keelung, Keelung 20401, Taiwan.
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Chen
authors.affiliation: Chia-Ying Yu, Li-Wei Chen, Tsung-Shih Lee, Rong-Nan Chien, Department of Gastroenterology, Chang Gung Memorial Hospital and University at Keelung, Keelung 20401, Taiwan.
authors.forename: Tsung-Shih
authors.initials: TS
authors.lastname: Lee
authors.affiliation: Chia-Ying Yu, Li-Wei Chen, Tsung-Shih Lee, Rong-Nan Chien, Department of Gastroenterology, Chang Gung Memorial Hospital and University at Keelung, Keelung 20401, Taiwan.
authors.forename: Rong-Nan
authors.initials: RN
authors.lastname: Chien
authors.affiliation: Chia-Ying Yu, Li-Wei Chen, Tsung-Shih Lee, Rong-Nan Chien, Department of Gastroenterology, Chang Gung Memorial Hospital and University at Keelung, Keelung 20401, Taiwan.
authors.forename: Ming-Fang
authors.initials: MF
authors.lastname: Hsieh
authors.affiliation: Chia-Ying Yu, Li-Wei Chen, Tsung-Shih Lee, Rong-Nan Chien, Department of Gastroenterology, Chang Gung Memorial Hospital and University at Keelung, Keelung 20401, Taiwan.
authors.forename: Kun-Chun
authors.initials: KC
authors.lastname: Chiang
mesh_terms: D000428:Alcohol Drinking; D001201:Ascites / Q000209:etiology; D001706:Biopsy; D004932:Esophageal and Gastric Varices / Q000209:etiology; D017809:Fatal Outcome; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D010382:Peliosis Hepatis / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D012307:Risk Factors; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014850:Waiting Lists
chemical_list: D007166:Immunosuppressive Agents
keywords: Liver neoplasm; Peliosis hepatis; Portal hypertension; Renal failure; Renal transplantation