title: ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts.
abstract: OBJECTIVE
  To examine the relevance of ABCC2 polymorphisms to drug responsiveness in epilepsy cohorts from the Asia Pacific region.
  
  
  METHODS
  The rs2273697 and rs3740066 polymorphisms were genotyped in 2056 Malaysian (55%), Hong Kong (32%) and Japanese (13%) epilepsy patients.
  
  
  RESULTS
  Significant allele association of rs2273697 was observed in Chinese females with epilepsy, Malaysian Chinese patients with generalized seizure and Japanese patients with partial seizure for the AA versus GG genotype model and Malaysian Chinese patients with generalized seizure for the GA versus GG and autosomal dominant models. Significant association of the rs3740066 allele was observed in Malaysian females of Malay origin with cryptogenic epilepsy and Chinese patients with partial seizure and for genotypes in Malay patients with cryptogenic epilepsy for the CT versus CC and autosomal dominant genotype models. Significant results were observed for all haplotypes, but following Bonferroni correction, only the GT haplotype in Chinese patients remained significant.
  
  
  CONCLUSIONS
  This study suggests that the GT haplotype might be a risk factor for resistance to medication in Chinese patients.
authors.affiliation: Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Hidayati Mohd
authors.initials: HM
authors.lastname: Sha'ari
authors.forename: Batoul Sadat
authors.initials: BS
authors.lastname: Haerian
authors.forename: Larry
authors.initials: L
authors.lastname: Baum
authors.forename: Junji
authors.initials: J
authors.lastname: Saruwatari
authors.forename: Hui Jan
authors.initials: HJ
authors.lastname: Tan
authors.forename: Mohd Hanip
authors.initials: MH
authors.lastname: Rafia
authors.forename: Azman Ali
authors.initials: AA
authors.lastname: Raymond
authors.forename: Patrick
authors.initials: P
authors.lastname: Kwan
authors.forename: Takateru
authors.initials: T
authors.lastname: Ishitsu
authors.forename: Kazuko
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Kheng Seang
authors.initials: KS
authors.lastname: Lim
authors.forename: Zahurin
authors.initials: Z
authors.lastname: Mohamed
mesh_terms: D000328:Adult; D000483:Alleles; D000927:Anticonvulsants / Q000627:therapeutic use*; D044466:Asian People / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics*; D004827:Epilepsy / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D000927:Anticonvulsants; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C000715087:ABCC2 protein, human