title: Increased production of autoantibodies and specific antibodies in response to influenza virus vaccination in physically active older individuals.
abstract: Immunosenescence is associated to aging and among many changes in immune response is reported a reduced response to vaccination and an increase in the number of cases of autoimmunity, caused by autoantibodies known as natural antibodies whose function, according to reports, would be protection against infection and inflammation. Although immunosenescence is an irreversible process, regular moderate exercise can attenuate some aspects of the decline in the immune system. So, the aim of this study was to investigate the humoral immune response in physically active elderly individuals before and 30 days after vaccination against influenza virus. The results showed that the percentage of individuals positive for antinuclear antibodies and serum immunoglobulin M and G levels after vaccination were higher in the group that exercised regularly than in the sedentary group. We were also able to demonstrate a significant correlation between levels of natural autoantibodies and response to vaccination.
authors.affiliation: Department of Microbiology and Immunology, Federal University of São Paulo, Brazil.
authors.forename: André L L
authors.initials: AL
authors.lastname: Bachi
authors.affiliation: Department of Otorhinolaryngology, Federal University of São Paulo, Brazil.
authors.forename: Vinicius M
authors.initials: VM
authors.lastname: Suguri
authors.affiliation: Department of Preventive Medicine, Federal University of São Paulo, Brazil.
authors.forename: Luiz Roberto
authors.initials: LR
authors.lastname: Ramos
authors.affiliation: Department of Microbiology and Immunology, Federal University of São Paulo, Brazil.
authors.forename: Mario
authors.initials: M
authors.lastname: Mariano
authors.affiliation: Department of Otorhinolaryngology, Federal University of São Paulo, Brazil.
authors.forename: Mauro
authors.initials: M
authors.lastname: Vaisberg
authors.affiliation: Department of Microbiology and Immunology, Federal University of São Paulo, Brazil.
authors.forename: Jose D
authors.initials: JD
authors.lastname: Lopes
keywords: ANAs, antinuclear autoantibodies; Antinuclear autoantibodies; B cells; BMI, body mass index; Elderly people; Exercise; IgG, immunoglobulin G; IgM, immunoglobulin M; Influenza virus; KLH, keyhole-limpet hemocyanin; SLE, systemic lupus erythematosus; SRCR, scavenger receptor cysteine-rich receptor; anti-dsDNA, anti-double stranded DNA antibody