title: Asymmetric palladium-catalyzed directed intermolecular fluoroarylation of styrenes.
abstract: A mild catalytic asymmetric direct fluoro-arylation of styrenes has been developed. The palladium-catalyzed three-component coupling of Selectfluor, a styrene and a boronic acid, provides chiral monofluorinated compounds in good yield and in high enantiomeric excess. A mechanism proceeding through a Pd(IV)-fluoride intermediate is proposed for the transformation and synthesis of an sp(3) C-F bond.
authors.affiliation: Novartis Institutes for Biomedical Research , Horsham,West Sussex, RH12 5AB, United Kingdom.
authors.forename: Eric P A
authors.initials: EP
authors.lastname: Talbot
authors.forename: Talita de A
authors.initials: Tde A
authors.lastname: Fernandes
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: McKenna
authors.forename: F Dean
authors.initials: FD
authors.lastname: Toste
mesh_terms: D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013343:Styrenes / Q000737:chemistry*
chemical_list: D006845:Hydrocarbons, Fluorinated; D013343:Styrenes; D010165:Palladium