title: Transfusion transmitted infections in thalassaemics: need for reappraisal of blood screening strategy in India.
abstract: The aim of the study was to assess the blood safety in India through prevalence in thalassaemic population. Safety of the blood supply is a subject of great concern for all recipients. This review attempts to assess the relevance and format of tests for viruses in the context of transfusion transmitted infection (TTI) prevalence in India. Serological marker testing for human immunodeficiency virus-1/2 (HIV-1/2), hepatitis C virus (HCV) and hepatitis B virus (HBV) is mandatory in India. Numerous TTI incidents in the repeat recipients supported by results from nucleic acid technology (NAT) testing indicate the deficiencies in blood safety. The β-thalassaemic population (3-17%) in India has been used to reflect on blood safety. The prevalence of HIV-1/2, HCV and HBV in the Indian donor population, the limitations in accessing safe donors, quality of serological tests and the impact on repeat recipients is evaluated. The reports point to prevalence of ˜2% of viral diseases in the blood donor population, and the insufficiency of serology testing resulting in up to 45% TTIs in thalassaemics. The revelation by individual donation (ID) NAT testing, of 1 per 310 units being serology negative-NAT reactive is alarming. Extrapolating the serology negative NAT reactive yields, for an annual blood supply of 7.9 million units, 23,700 units or nearly 100,000 blood components are likely to be infectious. Though the cost for ID-NAT testing is considered unaffordable for a medium development country such as India, the enormity of TTIs will place an unmanageable cost burden on the society.
authors.affiliation: Research Diagnostics, Inc., Bengaluru, India.
authors.forename: V
authors.initials: V
authors.lastname: Shyamala
mesh_terms: D001803:Blood Transfusion; D017848:Blood-Borne Pathogens; D046148:Donor Selection; D006801:Humans; D007194:India; D013789:Thalassemia / Q000453:epidemiology / Q000628:therapy; D014777:Virus Diseases / Q000453:epidemiology / Q000635:transmission / Q000821:virology
keywords: nucleic acid technology testing; occult infections; repeat recipients; serology markers; transfusion transmitted viral infections in India; window period; ß-thalassaemics