title: Masked hypodiploidy in anaplastic meningiomas by duplication of the original clone found in atypical meningiomas: illustration of the evolution of genetic alterations.
abstract: Meningiomas are common, usually benign neoplasms of the central nervous system. Atypical and anaplastic meningiomas can be aggressive, show more rapid growth, and a greater propensity to recur following resection. General consensus believes that genetic abnormalities leading to anaplastic transformation are present at initial tumor presentation; however, this has not been demonstrated by array-comparative genome hybridization. We confirm the hypothesis by showing the evolution of genetic alterations in the transformation of an atypical meningioma to an anaplastic meningioma. Additionally, we provide potential genes responsible for malignant transformation of meningiomas, which, with further research, may provide diagnostic and therapeutic implications.
authors.affiliation: Department of Pathology, Saint Louis University, Saint Louis, Missouri, USA.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Ely
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Guzman
authors.forename: Laura S
authors.initials: LS
authors.lastname: Calvey
authors.forename: Jacqueline R
authors.initials: JR
authors.lastname: Batanian
mesh_terms: D060965:Clonal Evolution; D017353:Gene Deletion; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology*; D008579:Meningioma / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D011003:Ploidies
keywords: 14q and 22q in meningiomas; anaplastic meningiomas; atypical meningiomas; hypodiploidy/hyperdiploidy; loss of 1p