title: Metastatic carcinoma to percutaneous endoscopic gastrostomy tube sites. A report of five cases.
abstract: OBJECTIVE
  To characterize the clinicopathologic features of metastatic carcinomas at percutaneous endoscopic gastrostomy (PEG) tube sites.
  
  
  METHODS
  We reviewed the metastatic malignancies at PEG tube sites (2002-2011).
  
  
  RESULTS
  Five patients were identified, each with primary head and neck keratinizing squamous cell carcinoma. The metastases had a mean size of 6.08 cm (95% confidence interval [CI], 3.75-8.41). The time from PEG tube placement to metastasis diagnosis was 9.8 months (95% CI, 6.59-13.01). The survival times from PEG tube placement and from metastasis diagnosis were 23.5 (95% CI, 7.65-39.35) and 13.7 (95% CI, 0-31.08) months, respectively. Compared with a meta-analysis of the largest case series, our male patients were significantly older (mean, 73 years; 95% CI, 62.2-83.9 vs mean 59 years, 95% CI, 56.0-62.0) but had similar survival times.
  
  
  CONCLUSIONS
  Despite their older ages, our male patients had similar survival times to those reported previously. Larger series are needed to confirm our findings and explore the causes.
authors.affiliation: Dept of Pathology, 6 Founders, 3400 Spruce St, Philadelphia, PA 19104; Kathleen. Montone@uphs.upenn.edu.
authors.forename: Lanjing
authors.initials: L
authors.lastname: Zhang
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Dean
authors.forename: Emma E
authors.initials: EE
authors.lastname: Furth
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Weinstein
authors.forename: Virginia A
authors.initials: VA
authors.lastname: LiVolsi
authors.forename: Kathleen T
authors.initials: KT
authors.lastname: Montone
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000556:secondary*; D016099:Endoscopy, Gastrointestinal / Q000009:adverse effects; D005260:Female; D005774:Gastrostomy / Q000009:adverse effects*; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: Head and neck cancer; Metastasis; Percutaneous endoscopic gastrostomy; Squamous cell carcinoma; Survival