title: Myo-inositol modulates insulin and luteinizing hormone secretion in normal weight patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate hormonal dynamics in a group of non-obese polycystic ovary syndrome (PCOS) patients under myo-inositol (MYO) administration.
  
  
  METHODS
  Hormonal profiles, insulin response to oral glucose tolerance test (OGTT) and luteinizing hormone (LH) response to gonadotropin-releasing hormone (GnRH) stimulation test before and after the administration of a preparation of MYO (3 g p.o. daily) mixed with lactoferrin and bromelin, in a group (n = 24) of normal weight PCOS patients.
  
  
  RESULTS
  After the treatment interval, body mass index (BMI) did not change while LH, LH/follicle-stimulating hormone, 17-hydroxy-progesterone and androstenedione decreased significantly. Insulin response to OGTT was significantly reduced after the treatment interval (P < 0.05) as well as GnRH-induced LH response (P < 0.05). High-sensitivity C-reactive protein decreased significantly after the treatment interval.
  
  
  CONCLUSIONS
  MYO administration positively modulates insulin sensitivity in non-obese PCOS patients without compensatory hyperinsulinemia, improving hormonal parameters. The presence of bromelin in the formulation modulated the pro-inflammatory state that characterizes PCOS, independently of BMI.
authors.affiliation: Department of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: Alessandro D
authors.initials: AD
authors.lastname: Genazzani
authors.forename: Susanna
authors.initials: S
authors.lastname: Santagni
authors.forename: Federica
authors.initials: F
authors.lastname: Ricchieri
authors.forename: Annalisa
authors.initials: A
authors.lastname: Campedelli
authors.forename: Erika
authors.initials: E
authors.lastname: Rattighieri
authors.forename: Elisa
authors.initials: E
authors.lastname: Chierchia
authors.forename: Giulia
authors.initials: G
authors.lastname: Marini
authors.forename: Giulia
authors.initials: G
authors.lastname: Despini
authors.forename: Alessia
authors.initials: A
authors.lastname: Prati
authors.forename: Tommaso
authors.initials: T
authors.lastname: Simoncini
mesh_terms: D001835:Body Weight; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005951:Glucose Tolerance Test; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006801:Humans; D007294:Inositol / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007986:Luteinizing Hormone / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D007328:Insulin; D007987:Gonadotropin-Releasing Hormone; D007294:Inositol; D007986:Luteinizing Hormone; D002097:C-Reactive Protein
keywords: C-reactive protein; hyperinsulinism; insulin resistance; myo-inositol; polycystic ovary syndrome