title: Simulation of oral glucose tolerance tests and the corresponding isoglycemic intravenous glucose infusion studies for calculation of the incretin effect.
abstract: The incretin effect, which is a unique stimulus of insulin secretion in response to oral ingestion of nutrients, is calculated by the difference in insulin secretory responses from an oral glucose tolerance test (OGTT) and a corresponding isoglycemic intravenous glucose infusion (IIGI) study. The OGTT model of this study, which is individualized by fitting the glucose profiles during an OGTT, was developed to predict the glucose profile during an IIGI study in the same subject. Also, the model predicts the insulin and incretin profiles during both studies. The incretin effect, estimated by simulation, was compared with that measured by physiologic studies from eight human subjects with normal glucose tolerance, and the result exhibited a good correlation (r > 0.8); the incretin effect from the simulation was 56.5% ± 10.6% while the one from the measured data was 52.5% ± 19.6%. In conclusion, the parameters of the OGTT model have been successfully estimated to predict the profiles of both OGTTs and IIGI studies. Therefore, with glucose data from the OGTT alone, this model could control and predict the physiologic responses, including insulin secretion during OGTTs and IIGI studies, which could eventually eliminate the need for complex and cumbersome IIGI studies in incretin research.
authors.affiliation: Interdisciplinary Program for Bioengineering, Graduate School, Seoul National University, Seoul, Korea.
authors.forename: Myeungseon
authors.identifier: 0000-0002-5554-2363
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Tae Jung
authors.identifier: 0000-0002-5078-6123
authors.initials: TJ
authors.lastname: Oh
authors.affiliation: Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea. ; Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea. ; Department of Biomedical Engineering, Seoul National University Hospital, Seoul, Korea.
authors.forename: Jung Chan
authors.identifier: 0000-0002-4546-0962
authors.initials: JC
authors.lastname: Lee
authors.affiliation: Interdisciplinary Program for Bioengineering, Graduate School, Seoul National University, Seoul, Korea.
authors.forename: Karam
authors.identifier: 0000-0001-6781-7435
authors.initials: K
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Min Young
authors.identifier: 0000-0002-1016-8056
authors.initials: MY
authors.lastname: Kim
authors.affiliation: Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea. ; Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea. ; Department of Biomedical Engineering, Seoul National University Hospital, Seoul, Korea.
authors.forename: Hee Chan
authors.identifier: 0000-0002-2112-426X
authors.initials: HC
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Young Min
authors.identifier: 0000-0002-2331-6126
authors.initials: YM
authors.lastname: Cho
authors.affiliation: Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea. ; Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea. ; Department of Biomedical Engineering, Seoul National University Hospital, Seoul, Korea.
authors.forename: Sungwan
authors.identifier: 0000-0002-9318-849X
authors.initials: S
authors.lastname: Kim
mesh_terms: D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis; D003198:Computer Simulation; D005260:Female; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D005951:Glucose Tolerance Test; D006801:Humans; D054795:Incretins / Q000097:blood*; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects; D008875:Middle Aged; D008962:Models, Theoretical; D012372:ROC Curve
chemical_list: D001786:Blood Glucose; D054795:Incretins; D007328:Insulin; D005947:Glucose
keywords: Incretins; Individualized Model; Isoglycemic Intravenous Glucose Infusions (IIGI); Oral Glucose Tolerance Test (OGTT)