title: Antibiotic resistance determinants of a group of multidrug-resistant Acinetobacter baumannii in China.
abstract: A group of Acinetobacter baumannii confers multidrug resistance, but the molecular epidemiology and multidrug resistance mechanisms are poorly understood. Nineteen isolates were identified, and the antimicrobial susceptibility profile was determined using the disc diffusion method. Then, PCR of 78 kinds of resistance-associated genes were performed. A novel variant of blaADC gene: blaADC-67 gene (Genbank accession No. JX169789) was prevalent in all 19 isolates. Moreover, ISAba1 could also provide strong promoter to upregulate the expression of blaADC67 to confer resistance to beta-lactam. This is the first report of emergence of blaADC-67 in A. baumannii worldwide, which might confer resistance to beta-lactam.
authors.affiliation: Department of Medical Laboratory, Ningbo No. 2 Hospital, Ningbo, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Xiao-Min
authors.affiliation: Department of Burn, Ningbo No. 2 Hospital, Ningbo, China.
authors.forename: Fan
authors.initials: F
authors.lastname: You-Fen
authors.affiliation: Department of Medical Laboratory, Ningbo No. 2 Hospital, Ningbo, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wei-Yun
authors.affiliation: Department of Bioinformatics, Wuxi Clone Gen-Tech Institute, Wuxi, China.
authors.forename: Mi
authors.initials: M
authors.lastname: Zu-Huang
authors.affiliation: Department of Medical Laboratory, Ningbo First Hospital, Ningbo, China.
authors.forename: Weng
authors.initials: W
authors.lastname: Xing-Bei
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D002681:China; D024901:Drug Resistance, Multiple, Bacterial; D005798:Genes, Bacterial; D008826:Microbial Sensitivity Tests / Q000379:methods; D011401:Promoter Regions, Genetic; D015854:Up-Regulation; D001618:beta-Lactamases / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001618:beta-Lactamases