title: Correlation of lipoprotein(a) with the extent of coronary artery disease in patients with established coronary atherosclerosis: gender differences.
abstract: OBJECTIVE
  To assess the gender differences in correlation lipoprotein(a) concentration with the extent of coronary artery disease in patients with established coronary artery disease.
  
  
  METHODS
  Blood lipids and lipoprotein(a) concentrations were measured in 351 consecutive patients (256 men and 95 women) who underwent coronary angiography between January and May 2010, and who had established coronary atherosclerosis (angiography score >1). A modified angiographic Gensini Score was used.
  
  
  RESULTS
  Mean angiographic score was 19.6 in men and 15.0 in women. Men had lower mean high-density lipoprotein cholesterol level than women (1.05 vs. 1.18 mmol/l) and lower mean apolipoprotein A level (1.41 vs. 1.53 g/l). Mean lipoprotein(a) level was higher in men than women (307.1 vs. 282.7 mg/l). Significant inverse correlation between high-density lipoprotein cholesterol and apoA with angiographic score was identified in women (r = -0.23, p = 0.028 and r = -0.26, p = 0.025), but not in men. Lipoprotein(a) level correlated significantly with angiographic score only in men (r = 0.168, p = 0.0185).
  
  
  CONCLUSIONS
  Gender differences were identified in patients with established coronary atherosclerosis in the relation of blood lipids and lipoprotein(a) levels with the extent of coronary artery disease.
authors.affiliation: Na Homolce Hospital Cardiovascular Center, Prague, Czech Republic filip.malek@homolka.cz.
authors.forename: Filip
authors.initials: F
authors.lastname: Málek
authors.affiliation: The National Institute of Public Health, Šrobárova 48, Praha, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Dvořák
authors.affiliation: Na Homolce Hospital Cardiovascular Center, Prague, Czech Republic.
authors.forename: Vladimíra
authors.initials: V
authors.lastname: Skalníková
authors.affiliation: Na Homolce Hospital Cardiovascular Center, Prague, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Mates
authors.affiliation: Na Homolce Hospital Cardiovascular Center, Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Kmoníček
authors.affiliation: Charles University, Prague, Czech Republic.
authors.forename: Zlata
authors.initials: Z
authors.lastname: Vávrová
authors.affiliation: Na Homolce Hospital Cardiovascular Center, Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Neužil
mesh_terms: D053241:Apoprotein(a) / Q000097:blood; D002784:Cholesterol / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D012737:Sex Factors
chemical_list: D017270:Lipoprotein(a); D008074:Lipoproteins; C030104:lipoprotein cholesterol; D002784:Cholesterol; D053241:Apoprotein(a)
keywords: Coronary artery disease; gender differences; lipoprotein(a)