title: Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation.
abstract: OBJECTIVE
  Resveratrol (RSV) regulates NAD bioavailability and sirtuin-related metabolism, which relates to aging, metabolic syndrome and non-alcoholic fatty liver disease. The purpose of this study was to investigate the effects of resveratrol on hepatic metaflammation in a rodent model of high-fat (HF) diet-induced obesity (DIO).
  
  
  METHODS
  DIO was induced in a subset of mice given an HF diet (45% kcal fat). After 6weeks of HF diet feeding, RSV was delivered via an osmotic pump for 4weeks. The experimental groups were as follows: 1) lean control fed with a standard diet, 2) HF diet-induced obese control, and 3) HF_RSV (8mg/kg/day). After 4weeks of each treatment, blood and liver tissues were collected and the indices of glucose control, serum and liver triglyceride (TG), sirtuin pathway, inflammation, and NOD-like receptor family, pryin domain containing 3 (NLRP3) inflammasome were analyzed.
  
  
  RESULTS
  Body weight and food intake were not altered by administering resveratrol. Glucose control was impaired, and serum and liver TG levels were increased by the HF diet. Hepatic inflammation was aggravated in mice fed with the HF diet, as shown by the increased levels of the pro-inflammatory markers interleukin-1 (IL-1), IL-6 and tumor necrosis factor-alpha in the liver. However, resveratrol administration significantly improved glucose control, and serum and liver TG contents. Also, resveratrol treatment reduced the levels of the pro-inflammatory markers. These improvements were accompanied by alterations in sirtuin pathway and NLRP3 inflammasome activation.
  
  
  CONCLUSIONS
  These results demonstrate that resveratrol ameliorates hepatic metaflammation, accompanied by alterations in NLRP3 inflammasome.
authors.affiliation: Department of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju, Korea. Electronic address: sjyang89@chonnam.ac.kr.
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Yang
authors.affiliation: Department of Food and Nutrition, Kyung Hee University, Seoul, Korea.
authors.forename: Yunsook
authors.initials: Y
authors.lastname: Lim
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002352:Carrier Proteins / Q000378:metabolism*; D059305:Diet, High-Fat / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D004435:Eating / Q000187:drug effects; D006505:Hepatitis / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D058847:Inflammasomes / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D009929:Organ Size / Q000187:drug effects; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D002352:Carrier Proteins; D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C492716:Nlrp3 protein, mouse; D013267:Stilbenes; D000077185:Resveratrol
keywords: Hepatic metaflammation; NLRP3 inflammasome; Non-alcoholic fatty liver disease; Resveratrol; Sirtuin