title: Biochemical markers of brain tumours.
abstract: The paper presents the results of neurospecific proteins S-100 and glial fibrillary acidic protein (GFAP) determination in blood serum samples of 145 neuro-oncology patients and 69 healthy people. The significant elevation of S-100 and GFAP was revealed in glioblastoma (G IV) patients compare to the patients with anaplastic astrocytoma (G III), benign meningioma (GI), celebral metastasis and healthy controls. The concentration of S-100 in blood serum of patients with anaplastic astrocytoma, benign meningioma, and celebral metastasis did not significantly differ among themselves, and in relation to the control group there was a significantly increase only in patients with cerebral metastasis. GFAP was characterized by high frequency of its detection in patients with glioblastoma (83%) compare to other groups of patients and healthy donors, in which it was practically undetectable. These data suggest the possibility of using GFAP as a marker of glioblastoma and S-100- as an additional biochemical criteria of cerebral lesions in oncology patients.
authors.forename: N V
authors.initials: NV
authors.lastname: Lyubimova
authors.forename: M G
authors.initials: MG
authors.lastname: Toms
authors.forename: R G
authors.initials: RG
authors.lastname: Fu
authors.forename: Yu V
authors.initials: YV
authors.lastname: Bondarenko
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000097:blood; D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000097:blood / Q000175:diagnosis*; D014408:Biomarkers, Tumor / Q000097:blood*; D001932:Brain Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000556:secondary; D016022:Case-Control Studies; D005260:Female; D005909:Glioblastoma / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008579:Meningioma / Q000097:blood / Q000175:diagnosis*; D008875:Middle Aged; D009418:S100 Proteins / Q000097:blood
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; C510602:Grap protein, human; D009418:S100 Proteins