title: Diversity oriented synthesis of novel haloglycolipids potentially useful for crystallization of integral membrane proteins.
abstract: A series of novel haloglycolipids were synthesized based on Cu(i) catalyzed Huisgen's [3 + 2] cycloaddition reaction of diversely functionalized azides and alkynes, using a mixture of N-bromosuccinimide and Cu(i) halide as the halogen source. Since halogen atoms, like bromine and iodine, with a very high scattering power facilitate the solving of crystal structures, the title haloglycolipids could prove to be invaluable in structure-based drug design involving membrane proteins as targets.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai-600036, India. laxminarayanchem@gmail.com.
authors.forename: Laxminarayan
authors.initials: L
authors.lastname: Sahoo
authors.forename: Anadi
authors.initials: A
authors.lastname: Singhamahapatra
authors.forename: Duraikkannu
authors.initials: D
authors.lastname: Loganathan
mesh_terms: D003460:Crystallization; D006017:Glycolipids / Q000138:chemical synthesis* / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D006017:Glycolipids; D008565:Membrane Proteins