title: Expression of AEG-1 and microvessel density correlates with metastasis and prognosis of oral squamous cell carcinoma.
abstract: Astrocyte elevated gene 1 (AEG-1) expression is up-regulated in various human cancers and plays an important role in tumorigenesis and progression. The aim of this study was to explore AEG-1 expression in oral squamous cell carcinoma (OSCC) and to assess whether it is associated with microvessel density (MVD), metastasis, and survival. Specimens from 87 patients with OSCC were investigated by immunohistochemistry staining for AEG-1 and MVD. By statistical analysis, we studied the correlations between the expression of AEG-1 and MVD and various clinicopathological factors, including overall survival (OS). We found that AEG-1 was highly expressed in 51.72% of OSCC. Expression was closely correlated with differentiation, clinical stage, T classification, and lymph node metastasis. The MVD had similar results. Expression of AEG-1 correlated positively with MVD. The lymph node metastatic rate in patients with high AEG-1/high MVD was significantly higher than in patients with high AEG-1/low MVD, low AEG-1/high MVD, or low AEG-1/low MVD. Patients with high AEG-1 expression showed far lower OS rates than those with low expression. For MVD, there were similar results. Only AEG-1 and MVD expression were independent prognostic factors for OS by multivariate analysis. Expression of AEG-1 may be correlated with tumor angiogenesis and metastasis and is a valuable prognostic factor in patients with OSCC.
authors.affiliation: Department of Dentistry, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors.forename: Xianyin
authors.initials: X
authors.lastname: Xia
authors.affiliation: Department of Dentistry, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors.forename: Ruirui
authors.initials: R
authors.lastname: Du
authors.affiliation: Department of Dentistry, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors.forename: Lingbo
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Dentistry, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address: hrbwangmei@163.com.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000096:biosynthesis*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011379:Prognosis; D016601:RNA-Binding Proteins; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins
keywords: Angiogenesis; Astrocyte-elevated gene 1; Metastasis; Microvessel density; Oral squamous cell carcinoma