title: Burkitt lymphoma after transplant: an aggressive lymphoproliferative disease.
abstract: Posttransplant lymphoproliferative disorder (Burkitt lymphoma) may occur after liver transplant. A 3.5-year-old boy who was 17 months after liver transplant developed multiple millimeter-sized nodular lesions in the liver. Before transplant, the patient tested seronegative for Epstein-Barr virus; within 1 month after transplant, he tested seropositive for Epstein-Barr virus (1000 copies). Biopsy of the liver nodules showed posttransplant lymphoproliferative disorder (Burkitt lymphoma). Tacrolimus was stopped, sirolimus was started, and the patient was treated with chemotherapy (etoposide, doxorubicin, cyclophosphamide, corticosteroids and intrathecal methotrexate). Remission was achieved, and follow-up at 76 months after transplant showed no recurrence of the posttransplant lymphoproliferative disorder. In conclusion, posttransplant lymphoproliferative disorder (Burkitt lymphoma) may occur after liver transplant, and monitoring Epstein-Barr virus level may helpful after transplant because of the association between Epstein-Barr virus and Burkitt lymphoma.
authors.affiliation: Department of Pathology, Baskent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Eylem
authors.initials: E
authors.lastname: Akar Özkan
authors.forename: B Handan
authors.initials: BH
authors.lastname: Özdemir
authors.forename: Aydıncan
authors.initials: A
authors.lastname: Akdur
authors.forename: E Ebru
authors.initials: EE
authors.lastname: Deniz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Haberal
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000821:virology; D002675:Child, Preschool; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D012074:Remission Induction; D013997:Time Factors; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D007166:Immunosuppressive Agents