title: [Effectiveness of iron amino acid chelate versus ferrous sulfate as part of a food complement in preschool children with iron deficiency, Medellín, 2011].
abstract: BACKGROUND
  Iron depleted deposits are the first link in the chain of events leading to iron deficiency which is the most prevalent nutritional shortage and main cause of anemia worldwide. This situation can be prevented through food fortification.
  
  
  OBJECTIVE
  To compare the efficacy of amino acid chelate iron with ferrous sulfate as fortifier of a dietary complement in preschoolers with iron deficiency.
  
  
  METHODS
  This study was a blinded clinical trial with randomized groups. We analyzed 56 preschoolers with iron deficiency (ferritin < 24 ng/ml) that received 13 g of milk with 12.5 mg of iron, either amino acid chelate or in the ferrous sulfate form. After two months, hemoglobin, hematocrit and serum ferritin concentrations were measured.
  
  
  RESULTS
  In the ferrous sulfate group, ferritin concentration increased from 18.8 ng/ml to 24.1 ng/ml, while the variation was of 18.4 ng/ml to 29.7 ng/ml in the amino acid chelate group, with statistically differences in both cases. Serum ferritin was different between groups, being higher in iron amino acid chelate group (p=0.022). Hemoglobin and hematocrit levels did not change after the intervention. Adverse reactions in the ferrous sulfate group were 35.7%, compared with 42.9% in the iron amino acid chelate group; 5 children had respiratory tract infection, without statistical differences.
  
  
  CONCLUSIONS
  Both compounds increased serum ferritin concentration, with a higher increase in those who were given milk with iron amino acid chelate. There were no differences in the adverse reactions and infections incidences between the groups.
authors.affiliation: Grupo de Investigación Ciencias Básicas, Universidad CES.
authors.forename: Maylen Liseth
authors.initials: ML
authors.lastname: Rojas
authors.affiliation: Grupo de Investigación Ciencias Básicas, Universidad CES.
authors.forename: Juliana
authors.initials: J
authors.lastname: Sánchez
authors.affiliation: Grupo de Investigación Ciencias Básicas, Universidad CES.
authors.forename: Óscar
authors.initials: Ó
authors.lastname: Villada
authors.affiliation: Grupo de Investigación Ciencias Básicas, Universidad CES.
authors.forename: Liliana
authors.initials: L
authors.lastname: Montoya
authors.affiliation: Grupo de Investigación Ciencias Básicas, Universidad CES.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Díaz
authors.affiliation: Grupo de Investigación Ciencias Básicas, Universidad CES.
authors.forename: Cristian
authors.initials: C
authors.lastname: Vargas
authors.affiliation: Grupo de Investigación Ciencias Básicas, Universidad CES.
authors.forename: Javier
authors.initials: J
authors.lastname: Chica
authors.affiliation: Grupo de Investigación Ciencias Básicas, Universidad CES.
authors.forename: Ana Milena
authors.initials: AM
authors.lastname: Herrera
mesh_terms: D000596:Amino Acids; D002675:Child, Preschool; D003105:Colombia; D003677:Deficiency Diseases / Q000178:diet therapy*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005296:Ferrous Compounds / Q000627:therapeutic use*; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D000090463:Iron Deficiencies; D008297:Male; D016896:Treatment Outcome
chemical_list: D000596:Amino Acids; D005296:Ferrous Compounds; D007502:Iron Chelating Agents; C020748:ferrous sulfate