title: Health benefits of wine: don't expect resveratrol too much.
abstract: Moderate consumption of red wine reduces the risk of heart disease and extends lifespan, which these healthy benefits are often attributed to its high antioxidant content. The relative contributions of wine polyphenols in healthy benefits were studied in this study. Among all wine polyphenols, caffeic acid was the richest one, while gallic acid showed the highest free radical scavenging activity. There was no significant difference between the prime red wine and the red wine adding 10-fold resveratrol on neuroprotective effects on SH-SY5Y cell line. The contribution percentage of resveratrol to the antioxidant activity of red wine was less than other tested polyphenols. It suggested that resveratrol may be negligible with respect to healthy benefits of red wine.
authors.affiliation: College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Limin
authors.initials: L
authors.lastname: Xiang
authors.affiliation: School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Xiao
authors.affiliation: College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Yihai
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; College of Life Science and Bio-pharmaceutical, Guangdong Pharmaceutical University, Guangzhou 510006, China.
authors.forename: Zebo
authors.initials: Z
authors.lastname: Huang
authors.affiliation: College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: hexiangjiu@hotmail.com.
authors.forename: Xiangjiu
authors.initials: X
authors.lastname: He
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D006801:Humans; D059808:Polyphenols / Q000032:analysis*; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry*; D014920:Wine / Q000032:analysis*
chemical_list: D000975:Antioxidants; D059808:Polyphenols; D013267:Stilbenes; D000077185:Resveratrol
keywords: Antioxidant activity; Polyphenols; Red wine; Resveratrol; SH-SY5Y cell