title: Proliferating cell unclear antigen-associated factor (PAF15): a novel oncogene.
abstract: Proliferating cell nuclear antigen (PCNA)-Associated Factor (PAF15) is a small protein containing a PCNA interacting motif and sequences for association with ubiquitin enzymes. In interaction with PCNA, PAF15 plays a key role in recruiting DNA replicative polymerase by double monoubiquitination at Lys(15) and Lys(24). Under DNA damage conditions, PAF15 regulates the switch from DNA replicative polymerase to translesion synthesis polymerase in order to bypass the replication-blocking lesions. Overexpression of PAF15 promotes the repair of ultraviolet-induced DNA damage and prevents cell death, whereas attenuation of PAF15 decreases DNA replication and cell survival. Ectopic expression of PAF15 in mouse fibroblasts increases colony formation and tumourigenicity. PAF15 is aberrantly increased in various human malignancies with poor prognosis. Collectively, PAF15 may contribute to carcinogenesis and represents one of the potential therapeutic targets in the treatment of cancer.
authors.affiliation: School of Science and Health, The University of Western Sydney, Australia.
authors.forename: Chanlu
authors.initials: C
authors.lastname: Xie
authors.affiliation: Central Clinical School and Bosch Institute, The University of Sydney and Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Mu
authors.initials: M
authors.lastname: Yao
authors.affiliation: School of Science and Health, The University of Western Sydney, Australia; Central Clinical School and Bosch Institute, The University of Sydney and Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia. Electronic address: q.dong@uws.edu.au.
authors.forename: Qihan
authors.initials: Q
authors.lastname: Dong
mesh_terms: D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans; D009857:Oncogenes; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics*
chemical_list: D018809:Proliferating Cell Nuclear Antigen
keywords: Cancer; DNA replication and DNA repair; KIAA0101; PAF15; PCNA associated factor