title: Clinicopathologic study of vulvar Paget's disease in China.
abstract: OBJECTIVE
  To assess the clinicopathologic characteristics of patients with vulvar Paget's disease who were admitted in our hospital or of cases reported in a Chinese journal.
  
  
  METHODS
  The age, disease course, clinical manifestation, pathologic diagnosis, treatment, and follow-up data of patients with vulvar Paget's disease were reviewed.
  
  
  RESULTS
  There were 85 cases of vulvar Paget's disease reviewed. The mean age of patients with vulvar Paget's disease was 64.4 years, and their mean disease course was 52.36 months. The patients' primary clinical manifestations were pruritus. Treatment included simple vulvectomy, wide local excision, partial vulvectomy, radical vulvectomy with/without groin dissection, and radiotherapy. Intraepithelial Paget's disease was the most common pathology type (61.5%) followed by invasive Paget's disease (20.0%). There were 7 patients who had a history of secondary malignancy. The mean follow-up period was 43.6 months. The recurrence rate was as high as 43.5%. No significant relationships between margin status, lymph node involvement, pathology type, and recurrence were found (p > .05).
  
  
  CONCLUSIONS
  Vulvar Paget's disease has a high local recurrence risk and a long-term follow-up is required.
authors.affiliation: Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, China.
authors.forename: Guoyan
authors.initials: G
authors.lastname: Liu
authors.forename: Bibo
authors.initials: B
authors.lastname: Yuan
authors.forename: Yingmei
authors.initials: Y
authors.lastname: Wang
authors.forename: Fengxia
authors.initials: F
authors.lastname: Xue
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D012008:Recurrence; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy