title: Enantioseparation of chiral pharmaceuticals in biomedical and environmental analyses by liquid chromatography: an overview.
abstract: This review aims to present the issues associated to enantioseparation of chiral pharmaceuticals in biological and environmental matrices using chiral stationary phases (CSP). Thus, it related some enantioselective methods in liquid chromatography (LC) and compares the importance given to chiral separation in biomedical and environmental fields. For that the most used CSP, the enantioselective chromatographic methods, their advantages and drawbacks were swiftly revised and compared. The recent advances and the limitations of chiral analytical methods in LC were also discussed.
authors.affiliation: CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal; CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal; Centro de Química Medicinal da Universidade do Porto (CEQUIMED-UP), Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
authors.forename: Ana R
authors.initials: AR
authors.lastname: Ribeiro
authors.affiliation: CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal; CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal.
authors.forename: Alexandra S
authors.initials: AS
authors.lastname: Maia
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos, CP 676, 13560-970 São Carlos, SP, Brazil.
authors.forename: Quezia B
authors.initials: QB
authors.lastname: Cass
authors.affiliation: CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal; Centro de Química Medicinal da Universidade do Porto (CEQUIMED-UP), Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal; Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123, Porto, Portugal. Electronic address: elizabeth.tiritan@iscsn.cespu.pt.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Tiritan
mesh_terms: D020811:Biomedical Technology / Q000379:methods; D002853:Chromatography, Liquid / Q000379:methods*; D004777:Environment; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004364:Pharmaceutical Preparations
keywords: Biological matrices; Chiral pharmaceuticals; Chiral stationary phases; Enantioselective chromatography; Environmental matrices