title: Breaking up isn't easy: myosin V and its cargoes need Dma1 ubiquitin ligase's help.
abstract: In this issue of Developmental Cell, Yau et al. (2014) report that degradation of cargo adapters releases yeast vacuoles and peroxisomes from myosin V (Myo2) and terminates organelle transport from the mother cell to the bud.
authors.affiliation: Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Winding
authors.affiliation: Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: vgelfand@northwestern.edu.
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Gelfand
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000378:metabolism*; D024701:Myosin Type V / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism*; D020675:Peroxisomes / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D014617:Vacuoles / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; C493792:Dma1 protein, S cerevisiae; C077512:MYO2 protein, S cerevisiae; D011956:Receptors, Cell Surface; D029701:Saccharomyces cerevisiae Proteins; C472499:VAC17 protein, S cerevisiae; D033921:Vesicular Transport Proteins; D024701:Myosin Type V; D018995:Myosin Heavy Chains