title: Hematopoietic SCT in Europe: data and trends in 2012 with special consideration of pediatric transplantation.
abstract: In all, 661 of 680 centers in 48 countries reported 37 818 hematopoietic SCT (HSCT) in 33 678 patients (14 165 allogeneic (42%), 19 513 autologous (58%)) in the 2012 survey. Main indications were leukemias, 10 641 (32%; 95% allogeneic); lymphoid neoplasias, 19 336 (57%; 11% allogeneic); solid tumors, 1630 (5%; 3% allogeneic); and nonmalignant disorders, 1953 (6%; 90% allogeneic). There were more unrelated donors than HLA-identical sibling donors (54% versus 38% (8% being mismatched related donor HSCT)). Cord blood was almost exclusive in allogeneic transplants (5% of total). Since 2011, the highest increases in allogeneic HSCT were for AML in CR1 (12%) and for myeloproliferative neoplasm (15%). For autologous HSCT the main increases were for plasma cell disorders (7%), non-Hodgkin lymphoma (4%) and autoimmune disease (50%). There were 4097 pediatric patients <18 years of age receiving HSCT, 2902 received an allogeneic and 1195 an autologous HSCT. Overall, 69% of allogeneic and 64% of autologous HSCT were performed in dedicated pediatric centers and the remainder in combined adult and pediatric centers. Distributions of diseases, donor types and stem cell source for all patients and pediatric patients in particular are shown. A percentage of centers fulfilling the annual required criteria for patient numbers for JACIE accreditation are provided.
authors.affiliation: EBMT Activity Survey Office, Division of Hematology, Department of Medicine, University Hospital, Basel, Switzerland.
authors.forename: J R
authors.initials: JR
authors.lastname: Passweg
authors.affiliation: EBMT Activity Survey Office, Division of Hematology, Department of Medicine, University Hospital, Basel, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Baldomero
authors.affiliation: BMT Unit, St Anna Kinderspital, Vienna, Austria.
authors.forename: C
authors.identifier: 0000000303698515
authors.initials: C
authors.lastname: Peters
authors.affiliation: Molecular Immunology Unit, UCL Institute of Child Health, London, UK.
authors.forename: H B
authors.initials: HB
authors.lastname: Gaspar
authors.affiliation: Paediatric HaematologyOncology, Policlinico G.B. Rossi, Verona, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cesaro
authors.affiliation: University of Heidelberg, Medizinische Klinik u. Poliklinik V, Heidelberg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Dreger
authors.affiliation: Institut Catalàd'Oncologia, Hospital Duran i Reynals, Barcelona, Spain.
authors.forename: R F
authors.initials: RF
authors.lastname: Duarte
authors.affiliation: Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: J H F
authors.initials: JH
authors.lastname: Falkenburg
authors.affiliation: Service de Médecine Interne, Hopital St Louis, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Farge-Bancel
authors.affiliation: Children's BMT Unit, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle-Upon-Tyne, UK.
authors.forename: A
authors.initials: A
authors.lastname: Gennery
authors.affiliation: JACIE Accreditation Committee, Basel, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Halter
authors.affiliation: University Hospital Eppendorf, Hamburg, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Kröger
authors.affiliation: St Anna Hospital, Ferrare, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Lanza
authors.affiliation: Department of Haematological Medicine, GKT School of Medicine, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Marsh
authors.affiliation: INSERM UMRs 938, Universite Pierre & Maris Curie, Hôpital Saint Antoine, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Mohty
authors.affiliation: Department of Haematology, Addenbrookes Hospital, Cambridge, UK.
authors.forename: A
authors.initials: A
authors.lastname: Sureda
authors.affiliation: Ospedale Santa Maria della Misericordia - Sezione di Ematologia, LocalitáSant Andrea delle Fratte, Perugia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Velardi
authors.affiliation: Anthony Nolan Research Institute, Royal Free Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Madrigal
mesh_terms: D000328:Adult; D064591:Allografts; D064592:Autografts; D016026:Bone Marrow Transplantation / Q000706:statistics & numerical data / Q000639:trends; D002648:Child; D036101:Cord Blood Stem Cell Transplantation / Q000706:statistics & numerical data / Q000639:trends; D003625:Data Collection; D005060:Europe; D018380:Hematopoietic Stem Cell Transplantation / Q000706:statistics & numerical data / Q000639:trends*; D006801:Humans; D014019:Tissue Donors