title: Agreement between central corneal thickness measured using Pentacam, ultrasound pachymetry, specular microscopy and optic biometer Lenstar LS 900 and the influence of intraocular pressure.
abstract: OBJECTIVE
  To compare central corneal thickness (CCT) values obtained by Lenstar (LE), Pentacam (PC), specular microscopy (SM) and ultrasound pachymetry (UP) in healthy corneas and study their influence on intraocular pressure (IOP) readings determined by Goldmann applanation tonometry (GAT).
  
  
  METHODS
  CCT was measured in 76 healthy subjects by LE, PC, SM and UP. We established Lin's concordance correlation coefficient (ρ-C) between different techniques. The influence of CCT on GAT was established through univariate linear regression models, IOP being the dependent variable.
  
  
  RESULTS
  The highest ρ-C was found between LE and SM at 0.94 (95% CI: 0.91-0.96) and between LE and UP at 0.95 (95% CI: 0.94-0.97). IOP readings showed less variability when CCT was determined using LE (7.7%, B = 0.16; 95% CI: 0.004-0.28).
  
  
  CONCLUSIONS
  Although CCT values obtained with UP, PC, SM and LE show good correlation, these methods are not completely interchangeable. The amount of IOP variation differs when CCT is determined using LE or SM.
authors.affiliation: Department of Ophthalmology, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Borrego-Sanz
authors.forename: F
authors.initials: F
authors.lastname: Sáenz-Francés
authors.forename: M
authors.initials: M
authors.lastname: Bermudez-Vallecilla
authors.forename: L
authors.initials: L
authors.lastname: Morales-Fernández
authors.forename: J M
authors.initials: JM
authors.lastname: Martínez-de-la-Casa
authors.forename: E
authors.initials: E
authors.lastname: Santos-Bueso
authors.forename: L
authors.initials: L
authors.lastname: Jañez
authors.forename: J
authors.initials: J
authors.lastname: García-Feijoo
mesh_terms: D000328:Adult; D003315:Cornea / Q000033:anatomy & histology*; D063171:Corneal Pachymetry; D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008853:Microscopy; D009929:Organ Size; D010781:Photography; D015203:Reproducibility of Results; D014065:Tonometry, Ocular