title: Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma.
abstract: The aim of this study was to investigate tumor biomarker carbohydrate antigen 724 (CA724) in the serum of patients with carcinomas of the colon and rectum at various clinical stages. Serum was collected from 51 patients with colon carcinoma (CC) and 49 patients with rectal carcinoma (RC). CA724 levels were then measured in the different groups according to site, TNM classification, gender, age and metastastic status of the patients. The statistical significance of the differences between the groups was calculated by non-parametric statistics (Mann-Whitney and Kruskall-Wallis tests). We observed a close association between the serum CA724 levels and tumor migration in colorectal carcinoma (CRC) and opposite variation tendencies of CA724 in the evolution of CC and RC. In conclusion, we identified a close association between the serum levels of CA724 and tumor migration in CRC. The opposite variation tendencies of CA724 in the different evolution groups of CC and RC may reflect the differences between these two types of cancer. The evaluation of serum CA724 may be of monitoring and and predictive value and may also assist in the development of treatment strategies for CRC patients.
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023;
authors.forename: Zhanmeng
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023;
authors.forename: Zhe
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023;
authors.forename: Chunlin
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Clinical Biochemistry, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors.forename: Ziyi
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Clinical Biochemistry, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors.forename: Weibo
authors.initials: W
authors.lastname: Xuan
authors.affiliation: Department of Clinical Biochemistry, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors.forename: Yahui
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Clinical Biochemistry, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Zuo
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023;
authors.forename: Shuangyi
authors.initials: S
authors.lastname: Ren
keywords: carbohydrate antigen 724; colon carcinoma; rectal carcinoma; tumor markers