title: [Frequency of gene polymorphic variants (phase II) of biotransformation of GSTT1 and GSTM1 xenobiotics among long-livers (Precarpathian region)].
abstract: The molecular genetic study of genes (Phase II) of biotransformation of xenobiotics in 166 long livers and in 169 persons of the control group living in Ivano-Frankovsk region has been done. It was found that the frequency of functionally inactive allele of GSTT1 gene in all long livers (Ivano-Frankovsk region) reached to 24,70 and in control group - 20.12%. The frequency of functionally inactive allele of GSTM1 gene in all long livers (Ivano-Frankovsk region) reached to 46.99 and in control group--54.44%. The accommodations, in which persons under study lived, were divided into zones (the environmental factor was taken into account): environment level, moderate environmental pressures, ecology. Analysis of the combination of polymorphic variants of glutathione-S-transferase genes found that people who continued living in the zone of bad ecology, the combination of allelic GSTM1 "+"/GSTT1 "+" variants was significantly higher in long livers compared to the control group--54.55 and 35.09% respectively (chi2 = 4.29; OR = 2.22 (1.04-4.75)); the combination of allelic GSTM1 "-"/GSTT1 "+" variants was significantly higher in the control group, compared to long livers--21.82 and 43.86%, respectively (chi2 = 6.15; OR = 0.36 (0.16-0.82)). The significant difference between the frequencies of combinations of allelic GSTM1"+"/ GSTT1"+" GSTM1 "+"/GSTT1 "-" GSTM1 "-"/GSTT1 "+", GSTM1 "-"/GSTT1 "-" variants in long livers (Carpathian region) living in positive ecological zone and in bad ecological one--chi2 = 6.44; OR = 0.36-6058) respectively, was found.
authors.forename: R V
authors.initials: RV
authors.lastname: Kozovyĭ
authors.forename: S V
authors.initials: SV
authors.lastname: Podol'skaia
authors.forename: N G
authors.initials: NG
authors.lastname: Gorovenko
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000483:Alleles; D001711:Biotransformation / Q000235:genetics; D004247:DNA / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D005982:Glutathione Transferase / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D014455:Ukraine; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D004247:DNA; D005982:Glutathione Transferase; D015262:Xenobiotics; C413545:glutathione S-transferase T1