title: The relationship between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease risk: a meta-analysis.
abstract: OBJECTIVE
  Many studies were conducted to assess the relationship between Monoamine oxidase B (MAOB) A644G polymorphism and susceptibility to Parkinson disease (PD). However, the results were inconsistent and inconclusive.
  
  
  METHODS
  A meta-analysis was conducted from all published studies on the associations between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease.
  
  
  METHODS
  In this present study, the possible relationship between MAOB A644G polymorphism and PD risk was assessed by a meta-analysis. Eligible articles were identified for the period up to March 2013. Pooled odds ratios (OR) with 95% confidence intervals (CI) were appropriately derived from fixed-effects models.
  
  
  RESULTS
  Twenty case-control studies with a total of 2846 cases and 3508 controls were eligible. In a recessive model, MAOB A644G polymorphism was associated with PD risk (OR=1.32, 95% CI 1.18-1.47, P < .001). Subgroup analyses by ethnicity and gender also found significant relationships between this polymorphism and PD risk.
  
  
  CONCLUSIONS
  This meta-analysis suggested that MAOB A644G polymorphism may be associated with PD development.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Benshu Zhang, 153 Anshan Rd.,, Tianjin 30052, China, +86 022 23626407, drliuying@126.com.
authors.forename: Benshu
authors.initials: B
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D016017:Odds Ratio; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk; D012737:Sex Factors; D044465:White People / Q000235:genetics
chemical_list: D008995:Monoamine Oxidase