title: Neonatal outcomes of fetuses diagnosed with life-limiting conditions when individualized comfort measures are proposed.
abstract: OBJECTIVE
  To describe the neonatal outcomes of a case series of infants who were prenatally diagnosed with potential life-limiting conditions and to whom individualized comfort measures were offered.
  
  
  METHODS
  This is a retrospective analysis of the postnatal outcomes of a selected population of 49 infants prenatally diagnosed with potential life-limiting conditions whose parents were prenatally referred for counseling to the comfort care team.
  
  
  RESULTS
  The prenatal diagnosis was confirmed postnatally in 45 infants. The only four survivors had a significant discrepancy between prenatal and postnatal diagnosis. Whether they were treated with individualized comfort measures (n=28) or intensive care (n=17), all the newborns died with similar median age at death (2 days).
  
  
  CONCLUSIONS
  Diagnostic accuracy is the main determinant of outcomes. Provision of intensive care neither prevents the death of infants affected by life-limiting conditions nor prolongs life compared with that of infants treated with individualized comfort measures.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Morgan Stanley Children's Hospital of NewYork-Presbyterian, Columbia University Medical Center, New York, NY, USA.
authors.forename: E
authors.initials: E
authors.lastname: Parravicini
authors.affiliation: Division of Neonatology, Department of Pediatrics, Morgan Stanley Children's Hospital of NewYork-Presbyterian, Columbia University Medical Center, New York, NY, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Lorenz
mesh_terms: D000013:Congenital Abnormalities / Q000401:mortality / Q000628:therapy*; D005260:Female; D005333:Fetus; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009518:New York; D010166:Palliative Care / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D015996:Survival Rate