title: [Dapsone-induced methaemoglobinaemia].
abstract: Dapsone is used as an antibiotic for dermatological disorders and may cause methaemoglobinaemia. Specific treatment with intravenous methylene blue is the treatment of choice. We present a case of dapsone-induced methaemoglobinaemia. Arterial blood gas analysis showed that pH was 7.4, PaO2 11.7 kPa, PaCO2 4.5 kPa and bicarbonate concentration 21.9 mmol/l. The methaemoglobin level was found to be 32%. The symptoms were headache and tachycardia. Methylene blue was administered and the methaemoglobin level dropped to 5% within three days.
authors.affiliation: Ubberudgårdvej 15, 5491 Blommenslyst. dorterytter@live.dk.
authors.forename: Dorte
authors.initials: D
authors.lastname: Rytter
authors.forename: Monija
authors.initials: M
authors.lastname: Mrgan
mesh_terms: D003622:Dapsone / Q000506:poisoning*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005260:Female; D005493:Folic Acid Antagonists / Q000506:poisoning*; D006801:Humans; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000188:drug therapy; D008751:Methylene Blue / Q000627:therapeutic use; D013406:Suicide, Attempted; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004791:Enzyme Inhibitors; D005493:Folic Acid Antagonists; D003622:Dapsone; D008751:Methylene Blue