title: TWIST1hypermethylation is observed in pancreatic cancer.
abstract: Despite the growing evidence demonstrating thatTWIST1is a noteworthy tumor biomarker, little is known about the clinical significance ofTWIST1methylation in human primary pancreatic cancer. In the present study, the association ofTWIST1methylation with clinicopathological characteristics was examined in human primary pancreatic cancer. Primary pancreatic cancer specimens and corresponding healthy pancreatic non-tumorous tissues from 33 patients with pancreatic cancer were used. Methylation levels ofTWIST1were compared with clinicopathological characteristics. TheTWIST1methylation level was higher in pancreatic cancer compared to corresponding non-neoplastic pancreatic tissues. The meanTWIST1methylation was 66.7% for pancreatic cancer tissue and 15.0% for corresponding nonneoplastic pancreatic tissue (P=0.0004). These results suggested thatTWIST1methylation is a useful biomarker for the screening of pancreatic cancers. Studies using independent data sets are required to confirm these findings.
authors.affiliation: Departments of Gastroenterology and Hepatology and.
authors.forename: Manabu
authors.initials: M
authors.lastname: Sen-Yo
authors.affiliation: Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suehiro
authors.affiliation: Departments of Gastroenterology and Hepatology and.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kaino
authors.affiliation: Departments of Gastroenterology and Hepatology and.
authors.forename: Isao
authors.initials: I
authors.lastname: Sakaida
keywords: TWIST1; hypermethylation; pancreatic cancer