title: Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection.
abstract: Helicobacter suis infects the stomachs of both animals and humans, and can induce gastric mucosa-associated lymphoid tissue (MALT) lymphomas. It is known that CXC chemokine ligand 13 (CXCL13) is highly expressed in the Helicobacter-infected mice and gastric MALT lymphoma patients, but the pathway that links the activation of CXCL13 and the formation of gastric MALT lymphomas remains unclear. In this study, we examined whether CXCL13 neutralization would interfere with the formation of gastric lymphoid follicles including B cells, CD4+T cells, dendritic cells (DCs), and follicular DCs (FDCs) in germinal centers to determine the role of CXCL13 in the formation of B-cell aggregates after H. suis infection. Moreover, the expression of genes associated with the lymphoid follicle formation was also effectively suppressed by anti-CXCL13 antibody treatment. These results suggest that the upregulation of CXCL13 has an important role in the development of gastric MALT lymphomas and highlight the potential of anti-CXCL13 antibody for protection against Helicobacter-induced gastric diseases.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nishiumi
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.affiliation: Vaccinex, Inc. 1895 Mount Hope Avenue, Rochester, New York, USA.
authors.forename: E
authors.initials: E
authors.lastname: Klimatcheva
authors.affiliation: Vaccinex, Inc. 1895 Mount Hope Avenue, Rochester, New York, USA.
authors.forename: T
authors.initials: T
authors.lastname: Pandina
authors.affiliation: Third Department of Internal Medicine, Kyorin University, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Matsui
authors.affiliation: Graduate School of Pharmaceutical Science, Kitasato University, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Vaccinex, Inc. 1895 Mount Hope Avenue, Rochester, New York, USA.
authors.forename: M
authors.initials: M
authors.lastname: Zauderer
authors.affiliation: 1] Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan [2] The Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, Japan [3] Division of Metabolomics Research, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Azuma
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use*; D054382:Chemokine CXCL13 / Q000276:immunology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000188:drug therapy*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000276:immunology; D016481:Helicobacter Infections / Q000276:immunology*; D018247:Helicobacter heilmannii; D018442:Lymphoma, B-Cell, Marginal Zone / Q000276:immunology / Q000503:physiopathology; D051379:Mice; D016133:Polymerase Chain Reaction
chemical_list: D000911:Antibodies, Monoclonal; D054382:Chemokine CXCL13; C486386:Cxcl13 protein, mouse