title: [The burden of viral hepatitis in the Russian Federation requires reducing its progression for the long term, including chronic hepatitis C)].
abstract: OBJECTIVE
  To evaluate the impact of using the innovative antiviral drugs in patients with chronic hepatitis C (CHC) on the disease burden in the long term.
  
  
  METHODS
  A program was developed to increase the availability of innovative antiviral therapy (AVT) in patients with CHC covering the period from 2013 to 2020. To evaluate the impact of the program on the burden of hepatitis C (HC) in the Russian Federation, a Markov model of the disease progression was developed till 2030. Calculations were made in medical and social perspectives.
  
  
  RESULTS
  The implementation of the program will allow to decrease the medical costs by RBL 2 billion and budget costs, including disability payments, by RBL 3.8 billion by 2030. During this period, in GDP losses will decrease by RBL 1.1 trillion and the total burden of HC taking into account the cost of the program by RBL 1 trillion.
  
  
  CONCLUSIONS
  For the first time it was shown that the expanding coverage of CHC patients with innovative AVT will allow to reduce the costs of health and social services.
authors.forename: N D
authors.initials: ND
authors.lastname: Iushchuk
authors.forename: O O
authors.initials: OO
authors.lastname: Znoĭko
authors.forename: N A
authors.initials: NA
authors.lastname: Iakushechkina
authors.forename: S K
authors.initials: SK
authors.lastname: Zyrianov
authors.forename: S A
authors.initials: SA
authors.lastname: Shut'ko
authors.forename: P A
authors.initials: PA
authors.lastname: Belyĭ
authors.forename: A N
authors.initials: AN
authors.lastname: Kozina
authors.forename: S A
authors.initials: SA
authors.lastname: Chapurin
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Churilin
authors.forename: E A
authors.initials: EA
authors.lastname: Lugovskikh
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D017281:Cost of Illness; D018450:Disease Progression; D017048:Health Care Costs / Q000639:trends; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000191:economics* / Q000453:epidemiology; D006801:Humans; D016730:Program Development; D015397:Program Evaluation; D012426:Russia / Q000453:epidemiology
chemical_list: D000998:Antiviral Agents