title: Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients.
abstract: Personalized medicine has become essential in the treatment of lung cancer. However, the lung cancer-related gene expression profiles in non-small cell lung cancer (NSCLC) patients have not been elucidated. In this study, the correlation between gene expression profiles and clinicopathological characteristics was investigated in NSCLC patients. A total of 95 patients were enrolled in this study. The mRNA expression levels of 14 genes were assessed by multiplex branched DNA liquidchip (MBL) technology and data on 9 clinicopathological characteristics of patients were collected simultaneously. The correlation between gene expression and clinicopathological characteristics was investigated. Out of the 9 clinicopathological parameters, 6 were associated with several of the 14 genes analyzed. Patient gender was associated withTYMSandTOP2A. Clinical stage was associated withVEGFR2,KITandHER2. There was weak correlation between primary tumor size of ≤3 cm and the expression level ofKIT. The mRNA expression levels ofVEGFR2andHER2correlated with distant metastasis.BRCA1,TYMS,TOP2AandHER2were associated with histological type. Smoking correlated with higher expression levels ofBRCA1,TYMSandTOP2Aand lower expression levels ofPDGFRβ. The results were suggestive of correlation between the clinicopathological parameters of the NSCLC patients and the mRNA expression levels of certain lung cancer-related genes, includingBRCA1,TYMS,TOP2A,PDGFRβ,VEGFR2,KITandHER2.
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Beijing 101149, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Guo
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Beijing 101149, P.R. China.
authors.forename: Chongyu
authors.initials: C
authors.lastname: Su
authors.affiliation: General Hospital of the Chinese Armed Police Forces, Beijing 100039, P.R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Ren
authors.affiliation: Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Chu
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Beijing 101149, P.R. China.
authors.forename: Qiuyue
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: General Hospital of the Air Force, PLA, Beijing 100142, P.R. China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Beijing 101149, P.R. China.
authors.forename: Zitong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, P.R. China.
authors.forename: Guangyu
authors.initials: G
authors.lastname: An
authors.affiliation: Navy General Hospital, Beijing 100048, P.R. China.
authors.forename: Jingbo
authors.initials: J
authors.lastname: Kang
authors.affiliation: Navy General Hospital, Beijing 100048, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Beijing 101149, P.R. China.
authors.forename: Daping
authors.initials: D
authors.lastname: Yu
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Beijing 101149, P.R. China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Beijing 101149, P.R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Xiao
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Beijing 101149, P.R. China.
authors.forename: Yunsong
authors.initials: Y
authors.lastname: Li
authors.affiliation: SurExam Bio-Tech Co. Ltd., Guangzhou Technology Innovation Base, Science City, Guangzhou 510663, P.R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: SurExam Bio-Tech Co. Ltd., Guangzhou Technology Innovation Base, Science City, Guangzhou 510663, P.R. China.
authors.forename: Huiyi
authors.initials: H
authors.lastname: Yang
authors.affiliation: SurExam Bio-Tech Co. Ltd., Guangzhou Technology Innovation Base, Science City, Guangzhou 510663, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Yu
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Beijing 101149, P.R. China.
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Liu
keywords: clinicopathological; expression of genes; non-small cell lung cancer