title: HLA-DR polymorphism and primary biliary cirrhosis: evidence from a meta-analysis.
abstract: OBJECTIVE
  We undertook this study to review and quantitatively analyze the association between human leukocyte antigen (HLA) DR polymorphisms and susceptibility of primary biliary cirrhosis (PBC).
  
  
  METHODS
  All relevant publications on the association between HLA-DR polymorphisms and PBC were searched through June 2013. Odds ratios (OR) and confidence intervals (CI) for the comparisons between case and control group were calculated. Statistical analysis was performed using Stata 11.0 software.
  
  
  RESULTS
  Nineteen articles (or 20 studies including the substudies) were identified. For DR*7 allele, the ORs (95% CIs) were 1.530 (1.310, 1.788), 1.757 (1.285, 2.403) and 1.495 (1.211, 1.845) in overall, Asian and European populations, respectively. For DR*8 alleles, the ORs (95% CIs) were 3.158 (1.822, 5.475), 2.803 (2.420, 3.247) and 3.056 (2.573, 3.629) in Asian, American and European subgroups, respectively. The subgroup analysis for DR*11 and DR*13 showed a significant association in Asian and European population. For DR*12 and *15 alleles, the overall ORs (95% CIs) were 0.551 (0.404, 0.753) and 0.721 (0.607, 0.857). However, in subgroup analysis for DR*12 allele, the association was only found in Asian population. In addition, statistical significance exists in American and European populations in the subgroup analysis for DR*15 allele.
  
  
  CONCLUSIONS
  Our meta-analysis suggested that HLA-DR *7 and *8 allele polymorphisms contributed to the susceptibility of PBC, whereas DR*11, *12, *13 and *15 allele polymorphisms are protective factors in certain population.
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, China.
authors.forename: Man
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Ultrasonography, Hebei Chest Hospital, Shijiazhuang, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, China.
authors.forename: Qing-bao
authors.initials: QB
authors.lastname: Tian
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, China.
authors.forename: Mei-na
authors.initials: MN
authors.lastname: Rui
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, China. Electronic address: dwliu1956@hotmail.com.
authors.forename: Dian-wu
authors.initials: DW
authors.lastname: Liu
mesh_terms: D000483:Alleles; D044466:Asian People; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D044465:White People
chemical_list: D006684:HLA-DR Antigens
keywords: HLA; Meta-analysis; Polymorphism; Primary biliary cirrhosis