title: M30 does not predict the severity of hepatosteatosis, whereas adiponectin level declined with increase of ALT and the severity of hepatic steatosis.
abstract: BACKGROUND
  Nonalcoholic fatty liver disease (NAFLD) is an emerging problem all over the world. Because NAFLD and polycystic ovary syndrome (PCOS) are both closely related with insulin resistance, it would be necessary to determine the rate of presence of NAFLD in PCOS patients. So, this study aimed to investigate the utility of M30 in PCOS patients for the diagnosis of hepatic injury.
  
  
  METHODS
  Eighty patients with PCOS were included in the study. Ultrasonographic examination for the presence of hepatic steatosis, M30 serum level for determining the severity of ongoing apoptotic cell death in liver, and BARD index for defining the hepatic injury were performed during the study. 25-OH vitamin D and adiponectin level in sera were studied using ELISA (Enzyme-Linked ImmunoSorbent Assay).
  
  
  RESULTS
  M30 and vitamin D levels did not change significantly with the severity of hepatic steatosis. On the other hand, M30 levels showed a positive correlation with ALT and AST levels, and M30 level suddenly increased with the presence of hepatic steatosis from 159.7 to 170 U/l, however stabilized with the increasing severity of hepatic setatosis. Adiponectin levels decreased with the increasing severity of hepatic steatosis and significantly varied between ALT greater than 40 U/l and less than 40 U/l.
  
  
  CONCLUSIONS
  M30 level in serum increased with the appearance of hepatic steatosis and had a positive correlation with a noninvasive hepatic injury test, BARD (BMI, aspartate aminotransferase [AST]/alanine aminotransferase [ALT] ratio [AAR], diabetes mellitus [DM]) index. Adiponectin level decreased with the increasing ALT level and severity of hepatic steatosis.
authors.affiliation: Department of Endocrinology and Metabolism, Dışkapı Yıldırım Beyazıt Educational and Research Hospital, Ankara, Turkey.
authors.forename: Sedat
authors.initials: S
authors.lastname: Caner
authors.forename: Akif
authors.initials: A
authors.lastname: Altınbaş
authors.forename: Müyesser
authors.initials: M
authors.lastname: Saykı
authors.forename: Fatih
authors.initials: F
authors.lastname: Büyükcam
authors.forename: Barış
authors.initials: B
authors.lastname: Yılmaz
authors.forename: Erman
authors.initials: E
authors.lastname: Çakal
authors.forename: Şahin
authors.initials: Ş
authors.lastname: Çoban
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibaşı
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D015992:Body Mass Index; D004797:Enzyme-Linked Immunosorbent Assay; D005234:Fatty Liver / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006912:Hydroxyquinolines / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: C517687:5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline; D052242:Adiponectin; D006912:Hydroxyquinolines; D000410:Alanine Transaminase
keywords: M30; adiponectin; polycystic ovary syndrome; transaminases; vitamin D