title: A horizon-prioritizing method can identify gaps among genomic application guidelines.
abstract: In light of the increasing need by decision makers for a method of evaluating genomic applications based on the weight of evidence for their efficacy, several agencies have developed systems of classification. Here I review the horizon-scanning method for prioritizing genomics applications as described by Dotson et al. in this issue of CPT. Using the examples of the authors' Tier 1/Green classification for KRAS and Tier 2/Yellow for TPMT, I discuss differences between the guidelines issued by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and those by the National Comprehensive Cancer Network (NCCN). Additionally, I offer suggestions regarding classification of the Tier 3/Red genomics applications and the reproducibility of the data-curating algorithm of the horizon-scanning method.
authors.affiliation: Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
authors.forename: L
authors.initials: L
authors.lastname: Li
mesh_terms: D003657:Decision Making; D023281:Genomics; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods*