title: Size-dependent programming of the dynamic range of graphene oxide-DNA interaction-based ion sensors.
abstract: Graphene oxide (GO) is widely used in biosensors and bioimaging because of its high quenching efficiency, facile chemical conjugation, unique amphiphile property, and low cost for preparation. However, the nanometer size effect of GO on GO-DNA interaction has long been ignored and remains unknown. Here we examined the nanometer size effect of GO on GO-DNA interactions. We concluded that GO of ∼200 nm (lateral nanometer size) possessed the highest fluorescence quenching efficiency whereas GO of ∼40 nm demonstrated much weaker ability to quench the fluorescence. We employed the nanometer size effect of GO to program the dynamic ranges and sensitivity of mercury sensors. Three dynamic ranges (1 to 40 nM, 1 to 15 nM, and 0.1 to 5 nM) were obtained with this size modulation. The sensitivity (slope of titration curve) was programmed from 15.3 ± 1.27 nM(-1) to 106.2 ± 3.96 nM(-1).
authors.affiliation: Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences , Shanghai, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhang
authors.forename: Sisi
authors.initials: S
authors.lastname: Jia
authors.forename: Min
authors.initials: M
authors.lastname: Lv
authors.forename: Jiye
authors.initials: J
authors.lastname: Shi
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zuo
authors.forename: Shao
authors.initials: S
authors.lastname: Su
authors.forename: Lianhui
authors.initials: L
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Chunhai
authors.initials: C
authors.lastname: Fan
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
mesh_terms: D004247:DNA / Q000737:chemistry*; D005453:Fluorescence; D006108:Graphite / Q000737:chemistry*; D007477:Ions; D008628:Mercury / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D010316:Particle Size
chemical_list: D007477:Ions; D006108:Graphite; D004247:DNA; D008628:Mercury