title: Teratogenicity of asbestos in mice.
abstract: Possible teratogenicity of 3 different asbestos (crocidolite, chrysotile and amosite) was assessed in CD1(ICR) mice. Dams on day 9 of gestation were given a single intraperitoneal administration at dose of 40 mg/kg body weight of asbestos suspended in 2% sodium carboxymethyl cellulose solution in phosphate buffered saline, while dams in the control group were given vehicle (10 ml/kg body weight). Dams and fetuses were examined on day 18 of gestation. To compare with the control group, the mean percentage of live fetuses in implantations in the group given crocidolite and the incidence of dams with early dead fetuses in the groups given chrysotile or amosite were increased. While no external or skeletal malformation was observed in the control group, the incidence of external malformation (mainly reduction deformity of limb) in the group given amosite, and the incidences of skeletal malformation (mainly fusion of vertebrae) in the all dosed groups were significantly increased. The result indicated that asbestos (crocidolite, chrysotile and amosite) have fetotoxicity and teratogenicity in mice.
authors.affiliation: Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Fujitani
authors.forename: Motoki
authors.initials: M
authors.lastname: Hojo
authors.forename: Akiko
authors.initials: A
authors.lastname: Inomata
authors.forename: Akio
authors.initials: A
authors.lastname: Ogata
authors.forename: Akihiko
authors.initials: A
authors.lastname: Hirose
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Nishimura
authors.forename: Dai
authors.initials: D
authors.lastname: Nakae
mesh_terms: D000015:Abnormalities, Multiple; D000818:Animals; D017639:Asbestos, Amosite / Q000008:administration & dosage / Q000633:toxicity*; D017638:Asbestos, Crocidolite / Q000008:administration & dosage / Q000633:toxicity*; D017632:Asbestos, Serpentine / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000002:abnormalities* / Q000187:drug effects*; D005865:Gestational Age; D015994:Incidence; D007274:Injections, Intraperitoneal; D017880:Limb Deformities, Congenital / Q000139:chemically induced* / Q000453:epidemiology; D008431:Maternal-Fetal Exchange; D051379:Mice; D008813:Mice, Inbred ICR; D009139:Musculoskeletal Abnormalities / Q000139:chemically induced* / Q000453:epidemiology; D011247:Pregnancy; D013047:Specific Pathogen-Free Organisms; D064793:Teratogenesis / Q000187:drug effects*
chemical_list: D017632:Asbestos, Serpentine; D017638:Asbestos, Crocidolite; D017639:Asbestos, Amosite