title: FTO gene variant and risk of hypertension: a meta-analysis of 57,464 hypertensive cases and 41,256 controls.
abstract: OBJECTIVE
  Recent studies have suggested that fat mass and obesity-associated gene (FTO) may predispose individuals to develop hypertension. However, the results have been inconsistent. We performed a meta-analysis to investigate the relationship of FTO gene variant with risk of hypertension and influence of body mass index (BMI) on this risk.
  
  
  METHODS
  A systematic literature search in PubMed, Embase and ISI web of science databases was performed to identify eligible published literatures. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
  
  
  RESULTS
  A total of seven studies comprising 57,464 hypertensive cases and 41,256 controls met the inclusion criteria and were included in the meta-analysis. The FTO gene variant(s) showed significant association with the risk of hypertension (OR=1.16, 95% CI=1.07-1.25, P<0.001) which disappeared on adjustment for BMI (OR=1.04, 95% CI=0.98-1.10, P=0.162). In addition, stratified analysis demonstrated a significant association of the FTO variant with the risk of hypertension in obese subjects (OR=1.10, 95% CI=1.01-1.19, P=0.032) but not in non-obese individuals (OR=1.00, 95% CI=0.97-1.03, P=0.832). Subgroup analysis based on ethnicity showed significant association between FTO variant and hypertension in both European (OR=1.07, 95% CI=1.01-1.14, P=0.028) and Asian populations (OR=1.37, 95% CI=1.23-1.53, P<0.001). However, the association remained significant only in Asians (OR=1.17, 95% CI=1.01-1.35, P=0.035) but not in the Europeans (OR=1.02, 95% CI=0.97-1.07, P=0.390) on adjustment for BMI.
  
  
  CONCLUSIONS
  The present meta-analysis confirms that FTO genotype mediates obesity-related hypertension.
authors.affiliation: Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: He
authors.affiliation: Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, People's Republic of China.
authors.forename: Maosun
authors.initials: M
authors.lastname: Fu
authors.affiliation: Shandong Medical College (Jinan), Jinan, People's Republic of China.
authors.forename: Song
authors.initials: S
authors.lastname: Miao
authors.affiliation: EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Kikuko
authors.initials: K
authors.lastname: Hotta
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India. Electronic address: chandakgrc@ccmb.res.in.
authors.forename: Giriraj R
authors.initials: GR
authors.lastname: Chandak
authors.affiliation: Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, People's Republic of China. Electronic address: xibo2010@sdu.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Xi
mesh_terms: D000293:Adolescent; D000368:Aged; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D001794:Blood Pressure / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012307:Risk Factors
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: FTO; Hypertension; Meta-analysis; Obesity; Variant