title: [Factors associated with mitral regurgitation in men with ischemic heart disease without myocardial infarction].
abstract: Being independent predictor of cardiovascular mortality, mitral regurgitation (MR) has a negative influence on prognosis of ischemic heart disease (IHD) patients. Data on MR pathogenesis in IHD patients without myocardial infarction (MI) are insufficient.
  
  
  OBJECTIVE
  To reveal factors associated with MR in CAD men without myocardial infarction.
  
  
  METHODS
  Out of 16839 patients of the "Register of performed coronary angiography" we selected men with significant coronary stenosis (> or = 75% of lumen of at least one epicardial artery) who had no acute or previous MI: 1001 patients without MR and 66 patients with moderate and severe MR.
  
  
  RESULTS
  Men with MR were older (59.0 +/- 7.3 vs 52.8 +/- 7.4 year), more often had NYHA class III--IV heart failure (27.4 vs. 10.9%), arrhythmias (61.0 vs. 14.8%) (all p < 0.001), but rate of angina of Canadian Cardiovascular Society (CCS) class III--IV was lower among patients with MR (46.7 vs. 63.2%, p = 0.019). Echocardiographic index of left atrial dimension was higher in men with MR (23.5 +/- 2.9 vs. 20.3 +/- 2.1 mm/m2, p < 0.001) as well as all indices of linear echocardiographic dimensions of cardiac chambers; left ventricular (LV) ejection fraction was lower (51.0 +/- 10.7 vs 61.0 +/- 4.9%, p < 0.001) in this group. There were no differences in coronary angiographic data between groups. According to the mulrivariate analysis, MR was independently associated with arrhythmias (odds ratio [OR] 7.92; 95% confidence interval [CI] 3.21-19.57; p < 0.001), index of left atrial dimension (OR = 1.25; 95% CI 1.09-1.43; p = 0.002), LV ejection fraction (OR = 0.49; 95% CI 0.75-0.89; p < 0.001), CCS angina class (OR = 0.49; 95%CI 0.24-0.98; p = 0.044) and age (OR = 1.09; 95%CI 1.03-1.16; p = 0.005). MR in CAD men without MI was associated with arrhythmias, higher index of left atrium dimension, lower LV ejection fraction, worse CCS angina class and older age. No association between MR and localization of significant coronary lesions was found.
authors.forename: V A
authors.initials: VA
authors.lastname: Kuznetsov
authors.forename: E I
authors.initials: EI
authors.lastname: Iaroslvaskaia
authors.forename: D V
authors.initials: DV
authors.lastname: Krinochkin
authors.forename: G S
authors.initials: GS
authors.lastname: Pushkarev
authors.forename: L V
authors.initials: LV
authors.lastname: Mar'inskikh
mesh_terms: D017023:Coronary Angiography; D004452:Echocardiography; D004562:Electrocardiography; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D009203:Myocardial Infarction; D017202:Myocardial Ischemia / Q000150:complications* / Q000175:diagnosis; D012189:Retrospective Studies; D012307:Risk Factors; D012800:Siberia / Q000453:epidemiology; D015996:Survival Rate / Q000639:trends