title: Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function.
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Denise
authors.initials: D
authors.lastname: Wolleschak
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Mack
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Perner
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Frey
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Tina M
authors.initials: TM
authors.lastname: Schnöder
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Wagner
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Höding
authors.affiliation: Mousepathology, Animal Experimental Unit, Helmholtz-Center for Infection Research, Braunschweig, Germany.
authors.forename: Marina C
authors.initials: MC
authors.lastname: Pils
authors.affiliation: Department of Transfusion Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Parkner
authors.affiliation: Institute of Molecular and Clinical Immunology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Kliche
authors.affiliation: Institute of Molecular and Clinical Immunology, Otto-von-Guericke University Medical Center, Magdeburg, Germany Department of Immune Control, Helmholtz Center for Infection Research, Braunschwei, Germany.
authors.forename: Burkhart
authors.initials: B
authors.lastname: Schraven
authors.affiliation: Department of Experimental Pediatrics, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Hebel
authors.affiliation: Department of Experimental Pediatrics, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Brunner-Weinzierl
authors.affiliation: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Satish
authors.initials: S
authors.lastname: Ranjan
authors.affiliation: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Berend
authors.initials: B
authors.lastname: Isermann
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany German Cancer Research Center (DKFZ), Division of Epigenomics and Cancer Risk Factors, Heidelberg, Germany.
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Lipka
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Fischer
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany florian.h.heidel@gmail.com.
authors.forename: Florian H
authors.initials: FH
authors.lastname: Heidel
mesh_terms: D052160:Benzothiazoles / Q000494:pharmacology*; D006801:Humans; D010671:Phenylurea Compounds / Q000494:pharmacology*; D019311:Staurosporine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D051941:fms-Like Tyrosine Kinase 3 / Q000037:antagonists & inhibitors*
chemical_list: D052160:Benzothiazoles; D010671:Phenylurea Compounds; C544967:quizartinib; D051941:fms-Like Tyrosine Kinase 3; D019311:Staurosporine; C059539:midostaurin
keywords: AC220; FLT3-ITD; PKC412; T-cell activation; tyrosine kinase inhibitors