title: The amide of galacturonic acid with lysine as an immunodominant component of the lipopolysaccharide core region from Proteus penneri 42 strain.
abstract: Most Proteus lipopolysaccharides (LPSs) contain uronic acids or their amides with different amino acids, which together with other negatively charged components account for the acidic character of such LPS molecules. Previous studies have shown the significance of an amide of galacturonic acid with lysine [D-GalA(L-Lys)] for serological specificity of O-antigens from few P. mirabilis strains. In this work, the immunodominant role of GalALys was indicated for the P. penneri 42 LPS core region. The studies also showed the serological identity of core oligosaccharides from P. penneri 42 (O71), P. mirabilis 51/57 (O28) and R14/S1959 strains.
authors.affiliation: Department of General Microbiology, Institute of Microbiology, Biotechnology and Immunology, University of Łódź, Łódź, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Palusiak
authors.affiliation: Department of Immunochemistry, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Maciejewska
authors.affiliation: Department of Immunochemistry, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland amd Department of Biotechnology and Molecular Biology, University of Opole, Opole, Poland.
authors.forename: Czesław
authors.initials: C
authors.lastname: Ługowski
authors.affiliation: Department of Immunobiology of Bacteria, Institute of Microbiology, Biotechnology and Immunology, University of Łódź, Łódź, Poland.
authors.forename: Antoni
authors.initials: A
authors.lastname: Różalski
mesh_terms: D000577:Amides; D006603:Hexuronic Acids / Q000008:administration & dosage* / Q000737:chemistry; D016056:Immunodominant Epitopes / Q000008:administration & dosage; D008070:Lipopolysaccharides / Q000008:administration & dosage* / Q000737:chemistry / Q000276:immunology; D008239:Lysine / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D019081:O Antigens / Q000737:chemistry / Q000276:immunology*; D044095:Proteus penneri / Q000276:immunology
chemical_list: D000577:Amides; D006603:Hexuronic Acids; D016056:Immunodominant Epitopes; D008070:Lipopolysaccharides; D019081:O Antigens; C007819:galacturonic acid; D008239:Lysine