title: Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent.
abstract: A mild and efficient method for the synthesis of 3-trifluoromethylpyrazoles has been established via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent under transition-metal-free conditions.
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China. wangjb@pku.edu.cn.
authors.forename: Guojing
authors.initials: G
authors.lastname: Ji
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.forename: Songnan
authors.initials: S
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: Yuxuan
authors.initials: Y
authors.lastname: Ye
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006835:Hydrazones / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D008745:Methylation; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D006835:Hydrazones; D011720:Pyrazoles; D007455:Iodine