title: Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs.
abstract: A controlled study to assess the acaricidal efficacy of afoxolaner in dogs after a single oral administration was conducted against Haemaphysalis longicornis ticks. The study was characterized by a negative controlled randomized block design and included sixteen beagle dogs of both sexes. Starting two days before treatment, each dog was infested weekly with 50 ticks over 4 weeks. The number of live ticks was determined 48 h after treatment and then 48 h after each infestation. The mean dose of afoxolaner received by dogs was 3.0mg/kg (range: 2.5-3.1mg/kg). Afoxolaner rapidly eliminated pre-existing tick infestations (100% ticks killed within 48 h of treatment) and controlled weekly re-infestations (91.9% prophylactic efficacy at Day 30).
authors.affiliation: Merial Japan Limited, Tokyo Opera City Tower, 3-20-2, Nishi Shinjuku, Shinjuku-ku, Tokyo 163-1488, Japan. Electronic address: yumi.kondo@merial.com.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kondo
authors.affiliation: Merial Japan Limited, Tokyo Opera City Tower, 3-20-2, Nishi Shinjuku, Shinjuku-ku, Tokyo 163-1488, Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Kinoshita
authors.affiliation: Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096-4640, USA.
authors.forename: Marlene
authors.initials: M
authors.lastname: Drag
authors.affiliation: Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096-4640, USA.
authors.forename: Theodore S
authors.initials: TS
authors.lastname: Chester
authors.affiliation: Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096-4640, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Larsen
mesh_terms: D056810:Acaricides / Q000627:therapeutic use*; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000517:prevention & control; D004285:Dogs; D005260:Female; D007555:Isoxazoles / Q000008:administration & dosage*; D026863:Ixodidae; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage*; D011897:Random Allocation; D013984:Tick Infestations / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D056810:Acaricides; D007555:Isoxazoles; D009281:Naphthalenes; C000589002:afoxolaner
keywords: Afoxolaner; Dog; Efficacy; Haemaphysalis longicornis; Tick