title: Pregnancy-associated listeriosis in England and Wales.
abstract: Listeriosis is a rare but severe foodborne disease with low morbidity and high case-fatality rates. Pregnant women, unborn and newborn babies are among the high-risk groups for listeriosis. We examined listeriosis cases reported to the enhanced surveillance system in England and Wales from 1990 to 2010 to identify risk factors influencing outcome. Cases were defined as pregnancy-associated if Listeria monocytogenes was isolated from a pregnant woman or newborn infants aged <28 days. Of the 3088 cases reported, pregnancy-associated listeriosis accounted for 462 (15%) cases and 315 cases resulted in a live birth. Several factors were identified as affecting the severity and outcome of listeriosis in pregnancy in both mother and child including: presence or absence of maternal symptoms, gestational age at onset of symptoms, and clinical presentation in the infant (meningitis or septicaemia). Deprivation, ethnicity and molecular serotype had no effect on outcome.
authors.affiliation: Centre for Infectious Disease Surveillance and Control, Public Health England,UK.
authors.forename: A
authors.initials: A
authors.lastname: Awofisayo
authors.affiliation: Gastrointestinal Bacteria Reference Unit, Public Health England,UK.
authors.forename: C
authors.initials: C
authors.lastname: Amar
authors.affiliation: Centre for Infectious Disease Surveillance and Control, Public Health England,UK.
authors.forename: R
authors.initials: R
authors.lastname: Ruggles
authors.affiliation: Centre for Infectious Disease Surveillance and Control, Public Health England,UK.
authors.forename: R
authors.initials: R
authors.lastname: Elson
authors.affiliation: Centre for Infectious Disease Surveillance and Control, Public Health England,UK.
authors.forename: G K
authors.initials: GK
authors.lastname: Adak
authors.affiliation: Field Epidemiology Services, Public Health England,UK.
authors.forename: P
authors.initials: P
authors.lastname: Mook
authors.affiliation: Gastrointestinal Bacteria Reference Unit, Public Health England,UK.
authors.forename: K A
authors.initials: KA
authors.lastname: Grant
mesh_terms: D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D008088:Listeriosis / Q000453:epidemiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology; D011634:Public Health; D016019:Survival Analysis; D013997:Time Factors; D014852:Wales / Q000453:epidemiology