title: Accelerated orthodontic tooth movement following le fort I osteotomy in a rodent model.
abstract: OBJECTIVE
  In surgery-first accelerated orthognathic surgery, the clinical phenomenon of accelerated orthodontic tooth movement after osteotomy is a benefit compared with the conventional approach. However, because much of the literature on this phenomenon is based on empirical evidence and case reports, experimental animal-based studies are needed to verify and quantify this acceleration effect. The purpose of this prospective experimental study was to identify whether osteotomy procedures increase tooth movement.
  
  
  METHODS
  Le Fort I osteotomies were performed on the left maxillas in 15 male adult Sprague-Dawley rats. After surgery, a continuous force of 0.5 N was placed on the maxillary left first molar to move the tooth mesially. Another 15 rats had no surgery and served as controls. On days 1, 14, and 28, digital caliper measurements were taken to record tooth movement.
  
  
  RESULTS
  In the experimental group, the maxillary left first molars moved significantly more rapidly on days 14 and 28 (P < .05). Histologic findings showed more active alveolar bone remodeling.
  
  
  CONCLUSIONS
  Le Fort I osteotomy significantly accelerated the rate of orthodontic tooth movement. Histologically, more active and extensive bone remodeling was observed after osteotomy.
authors.affiliation: Doctor-in-Charge, Department of Oral and Craniomaxillofacial Science, Ninth People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Resident, Department of Oral and Craniomaxillofacial Science, Ninth People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Resident, Department of Oral and Craniomaxillofacial Science, Ninth People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
authors.forename: Jingting
authors.initials: J
authors.lastname: Lu
authors.affiliation: Resident, Department of Oral and Craniomaxillofacial Science, Ninth People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
authors.forename: Jiewen
authors.initials: J
authors.lastname: Dai
authors.affiliation: Professor, Department of Oral and Craniomaxillofacial Science, Ninth People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Fang
authors.affiliation: Professor, Department of Oral and Craniomaxillofacial Science, Ninth People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China. Electronic address: maxillofacsurg@163.com.
authors.forename: Steve G F
authors.initials: SG
authors.lastname: Shen
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000539:Alveolar Process / Q000502:physiology; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001696:Biomechanical Phenomena; D016723:Bone Remodeling / Q000502:physiology; D001862:Bone Resorption / Q000473:pathology; D003722:Dental Alloys / Q000737:chemistry; D007527:Isoenzymes / Q000032:analysis; D008297:Male; D008437:Maxilla / Q000502:physiology / Q000601:surgery*; D023421:Models, Animal; D008963:Molar / Q000033:anatomy & histology; D009532:Nickel / Q000737:chemistry; D009969:Orthodontic Wires; D010010:Osteoclasts / Q000502:physiology; D019340:Osteotomy, Le Fort / Q000379:methods*; D010513:Periodontal Ligament / Q000033:anatomy & histology; D059745:Piezosurgery / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical; D000071681:Tartrate-Resistant Acid Phosphatase; D013997:Time Factors; D014025:Titanium / Q000737:chemistry; D014087:Tooth Movement Techniques / Q000295:instrumentation / Q000379:methods*
chemical_list: D015415:Biomarkers; D003722:Dental Alloys; D007527:Isoenzymes; C040654:titanium nickelide; D009532:Nickel; D014025:Titanium; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase