title: BTB-ZF transcription factors, a growing family of regulators of early and late B-cell development.
abstract: The differentiation of early B-cell precursors in the bone marrow into the variety of mature and effector B-cell subsets of the periphery is a complex process that requires tight regulation at the transcriptional level. Different members of the broad complex, tramtrack, bric-à-brac and zinc finger (BTB-ZF) family of transcription factors have recently been shown to have key roles in many phases of B-cell development, including early B-cell development in the bone marrow, peripheral B-cell maturation and specialization into effector cells during an immune response. This review highlights the critical functions mediated by BTB-ZF transcription factors within the B-cell lineage and emphasizes how the deregulation of these transcription factors can lead to B-cell malignancies.
authors.affiliation: 1] Molecular Immunology Division, The Walter and Eliza Hall Institute, Parkville, Victoria, Australia [2] Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Chevrier
authors.affiliation: 1] Molecular Immunology Division, The Walter and Eliza Hall Institute, Parkville, Victoria, Australia [2] Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Corcoran
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D019337:Hematologic Neoplasms / Q000235:genetics / Q000276:immunology; D006801:Humans; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology*; D016335:Zinc Fingers / Q000235:genetics / Q000276:immunology*
chemical_list: D014157:Transcription Factors