title: Evaluation of cyclodextrin (sugammadex) for reversal of intense neuromuscular block of rocuronium and vecuronium, experimental and clinical studies.
abstract: This study evaluated and explored time course, efficacy, relation, safety, changes in heart rate, and blood pressure after a bolus dose of sugammadex or neostigmine for reversal of a prolonged rocuronium and vecuronium induced neuromuscular block. A total of 60 patients of both sexes, 'ASA' grade I, II and all were scheduled for elective surgery of 30-45 minutes duration. Informed oral consent was obtained from all patients to participate in this study. The results showed statistically significant progressive decrease of heart rate and blood pressure at 2, 5 and 10 minutes when compared to their basal values before anesthesia, then it starts to gain its normal value at 5 and 10 minutes, regardless the dose of sugammadex (effect of anesthesia). Also, heart rate and blood pressure showed statistically non-significant variance between groups of sugammadex when compared at any time of the study with the neostigmine groups (i.e. no effect of the dose on heart rate).
authors.forename: Hatem M Nasr
authors.initials: HM
authors.lastname: Alkenany
mesh_terms: D000293:Adolescent; D000328:Adult; D000732:Androstanols / Q000494:pharmacology*; D000818:Animals; D004336:Drug Antagonism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D000077123:Rocuronium; D000077122:Sugammadex; D014673:Vecuronium Bromide / Q000494:pharmacology*; D047408:gamma-Cyclodextrins / Q000494:pharmacology*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D014673:Vecuronium Bromide; D000077123:Rocuronium