title: American Society of Nephrology clinical pathological conference.
abstract: A 13-year-old girl presented with proteinuria and acute kidney failure. She was born at full term via cesarean delivery (due to nuchal cord), but there were no other prenatal or perinatal complications. In early childhood the patient had two hospitalizations at ages 4.5 and 9 years, respectively, the latter for pneumonia. She had no history of symptoms of kidney disease. She came to the hospital at age 12 years for routine bilateral molar extractions. She was treated with oral antibiotics and discharged after the procedure without complications. At age 13 years, 10 months after the molar extraction, she was seen by a pediatrician because of puffiness and increased BP. She had had respiratory symptoms 2 weeks before presentation. The pediatrician prescribed furosemide and amlodipine. A few days later, the patient returned to the pediatrician's office because of hand, ankle, and facial swelling and malaise. The pediatrician recommended hospitalization and the patient was admitted at this time.
authors.affiliation: The Children Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania;, †Division of Anatomic and Molecular Pathology, Washington University School of Medicine, St. Louis, Missouri, ‡Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Meyers
authors.forename: Helen
authors.initials: H
authors.lastname: Liapis
authors.forename: Mohamed G
authors.initials: MG
authors.lastname: Atta
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D002648:Child; D003176:Complement C3 / Q000032:analysis*; D003178:Complement C3 Nephritic Factor / Q000032:analysis; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005455:Fluorescent Antibody Technique; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000276:immunology / Q000628:therapy; D016030:Kidney Transplantation; D011237:Predictive Value of Tests; D006435:Renal Dialysis; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D003176:Complement C3; D003178:Complement C3 Nephritic Factor; D007166:Immunosuppressive Agents
keywords: acute renal failure; complement; membranoproliferative glomerulonephritis (MPGN); proteinuria; renal biopsy