title: Schisandra chinensis Baill, a Chinese medicinal herb, alleviates high-fat-diet-inducing non-alcoholic steatohepatitis in rats.
abstract: BACKGROUND
  he present study aims to explore whether Schisandra chinensis Baill, a Chinese, medicinal herb can alleviates high-fat-diet-inducing non-alcoholic steatohepatitis in rats.
  
  
  METHODS
  In the study, 24, male Wister rats with body weight between 180-220g, were included. The rats were randomly divided into four groups: model group, normal control group, rosiglitazone group, and Schisandra chinensis Baill group. The treatment lasted for 56, days. The high-fat diet used in the present study includes 25% lard, 2%, cholesterol 0.5%, sodium cholate, and 25%, Tween-80. The hepatic levels of superoxide dismutase (SOD), and malondialdehyde (MDA); the serum levels of total cholesterol (TC), and low-density lipoprotein cholesterol (LDLC), were detected.
  
  
  RESULTS
  We found that the hepatic levels of SOD were significantly lower, and the serum levels of TC, LDLC as well as, the hepatic levels of MDA in model group were significantly higher than those of normal control group; rosiglitazone group and Schisandra chinensis Baill group (P<0.05), indicates that non-alcoholic steatohepatitis rats were successfully induced by high-fat diet. Schisandra chinensis Baill group presented a significant lower serum levels of LDLC, than rosiglitazone group (P<0.05); and the hepatic levels of SOD in Schisandra chinensis Baill group were significantly lower than rosiglitazone group (P<0.05). However, no significant difference existed between Schisandra chinensis Baill group, and rosiglitazone group on the hepatic levels of MDA and the serum levels of TC (P>0.05).
  
  
  CONCLUSIONS
  It is then concluded that Schisandra chinensis Baill can significantly alleviate the non-alcoholic steatohepatitis of the rats induced by high-fat diet, and it may be used as a complementary therapy for rosiglitazone.
authors.affiliation: Zhejiang Cancer Hospital, Hangzhou, [310022], P.R. China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yao
authors.affiliation: Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, 310002, P.R. China.
authors.forename: Xiao-Chen
authors.initials: XC
authors.lastname: Liu
authors.affiliation: Women's Hospital, School of Medicine, Zhejiang University, No.2 Xueshi Road, Hangzhou, 310006, P.R. China.
authors.forename: Ying-Er
authors.initials: YE
authors.lastname: Gu
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000008:administration & dosage / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005234:Fatty Liver / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000077154:Rosiglitazone; D032141:Schisandra; D013482:Superoxide Dismutase / Q000378:metabolism; D045162:Thiazolidinediones / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D008078:Cholesterol, LDL; D004041:Dietary Fats; D004365:Drugs, Chinese Herbal; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D008315:Malondialdehyde; D002784:Cholesterol; D013482:Superoxide Dismutase
keywords: Non-alcoholic steatohepatitis; Schisandra chinensis Baill; high-fat diet