title: ErbB expressing Schwann cells control lateral line progenitor cells via non-cell-autonomous regulation of Wnt/β-catenin.
abstract: Proper orchestration of quiescence and activation of progenitor cells is crucial during embryonic development and adult homeostasis. We took advantage of the zebrafish sensory lateral line to define niche-progenitor interactions to understand how integration of diverse signaling pathways spatially and temporally regulates the coordination of these processes. Our previous studies demonstrated that Schwann cells play a crucial role in negatively regulating lateral line progenitor proliferation. Here we demonstrate that ErbB/Neuregulin signaling is not only required for Schwann cell migration but that it plays a continued role in postmigratory Schwann cells. ErbB expressing Schwann cells inhibit lateral line progenitor proliferation and differentiation through non-cell-autonomous inhibition of Wnt/β-catenin signaling. Subsequent activation of Fgf signaling controls sensory organ differentiation, but not progenitor proliferation. In addition to the lateral line, these findings have important implications for understanding how niche-progenitor cells segregate interactions during development, and how they may go wrong in disease states. DOI: http://dx.doi.org/10.7554/eLife.01832.001.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, United States.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Lush
authors.forename: Tatjana
authors.initials: T
authors.lastname: Piotrowski
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D002450:Cell Communication / Q000187:drug effects; D002454:Cell Differentiation; D049109:Cell Proliferation; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D005838:Genotype; D053403:Lateral Line System / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009154:Mutation; D058953:Neural Stem Cells / Q000187:drug effects / Q000378:metabolism*; D020880:Neuregulins / Q000378:metabolism; D010641:Phenotype; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D051880:Receptors, Notch / Q000378:metabolism; D012583:Schwann Cells / Q000187:drug effects / Q000378:metabolism*; D055153:Stem Cell Niche; D013997:Time Factors; D060449:Wnt Signaling Pathway / Q000187:drug effects; D015027:Zebrafish / Q000235:genetics / Q000378:metabolism; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D020880:Neuregulins; D047428:Protein Kinase Inhibitors; D051880:Receptors, Notch; D029961:Zebrafish Proteins; D051176:beta Catenin; D005346:Fibroblast Growth Factors; D066246:ErbB Receptors
keywords: glia; neuromast; stem cells