title: Severe symptomatic hypomagnesaemia induced by the chronic use of proton pump inhibitors: a case report of a patient with Zollinger-Ellison syndrome.
abstract: The association between proton pump inhibitor (PPI) therapy and hypomagnesaemia has been recognized since 2006. We report the case of a 51-year-old woman who developed severe symptomatic hypomagnesaemia after a long-term PPI therapy given for recurrent peptic ulcer disease. Hypomagnesaemia could only partially be resolved during substitution therapy, but was corrected after withdrawal of the PPI. Recurrence of hypomagnesaemia occurred after retreatment with PPIs, supporting the causal relationship. An underlying gastric acid hypersecretion (Zollinger-Ellison syndrome) was highly suspected and eventually controlled by a combination of a histamine 2-receptor antagonist and octreotide, without the need for further PPI therapy after 2 years of follow-up.
authors.forename: E
authors.initials: E
authors.lastname: Ströker
authors.forename: L
authors.initials: L
authors.lastname: Leone
authors.forename: Y
authors.initials: Y
authors.lastname: Vandeput
authors.forename: I
authors.initials: I
authors.lastname: Borbath
authors.forename: C
authors.initials: C
authors.lastname: Lefebvre
mesh_terms: D001774:Blood Chemical Analysis; D005260:Female; D006801:Humans; D008275:Magnesium Deficiency / Q000139:chemically induced*; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D015043:Zollinger-Ellison Syndrome / Q000188:drug therapy*
chemical_list: D054328:Proton Pump Inhibitors
keywords: Hypomagnesaemia,; Proton pump inhibitor,; Zollinger–Ellison syndrome