title: Dehydroevodiamine·HCl Improves Stress-Induced Memory Impairments and Depression Like Behavior in Rats.
abstract: Dehydroevodiamine·HCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and behavioral abnormality caused by stress. We demonstrated that DHED can improve stress-induced memory impairments and depression-like behaviors by using open-field test, Y-maze test and forced swimming test. DHED treatment significantly recovered the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. Our results suggested that DHED is a potential drug candidate for neuronal death, memory impairment and depression induced by stress.
authors.affiliation: Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799, Korea. ; Korea Brain Research Institute (KBRI), Daegu 700-010, Korea.
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799, Korea. ; Braintropia Co. Ltd., Anyang 431-716, Korea.
authors.forename: Ki Young
authors.initials: KY
authors.lastname: Shin
authors.affiliation: Department of Pharmacology, Gachon University of Medicine and Science, Incheon 406-799, Korea.
authors.forename: Keun-A
authors.initials: KA
authors.lastname: Chang
authors.affiliation: Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799, Korea.
authors.forename: Sangzin
authors.initials: S
authors.lastname: Ahn
authors.affiliation: Korea Brain Research Institute (KBRI), Daegu 700-010, Korea.
authors.forename: Hee Soon
authors.initials: HS
authors.lastname: Choi
authors.affiliation: Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799, Korea.
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Korea Brain Research Institute (KBRI), Daegu 700-010, Korea.
authors.forename: Yoo-Hun
authors.initials: YH
authors.lastname: Suh
keywords: DHED; Depression; Fluoxetine; Memory; Stress