title: Methods-based proficiency testing in molecular genetic pathology.
abstract: This Perspectives article describes methods-based proficiency testing (MBPT), the benefits and limitations of MBPT, why the time is right for MBPT in molecular diagnostics, and how MBPT for next-generation sequencing is being developed by the College of American Pathologists.
authors.affiliation: Department of Pathology, Stanford University Medical Center, Stanford, California; Department of Pediatrics, Stanford University Medical Center, Stanford, California. Electronic address: ischrijver@stanfordmed.org.
authors.forename: Iris
authors.initials: I
authors.lastname: Schrijver
authors.affiliation: Transformation Program Office, College of American Pathologists, Northfield, Illinois.
authors.forename: Nazneen
authors.initials: N
authors.lastname: Aziz
authors.affiliation: Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois; Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Jennings
authors.affiliation: Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.
authors.forename: Carolyn Sue
authors.initials: CS
authors.lastname: Richards
authors.affiliation: Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah; ARUP Laboratories Institute for Clinical and Experimental Pathology, Salt Lake City, Utah.
authors.forename: Karl V
authors.initials: KV
authors.lastname: Voelkerding
authors.affiliation: Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Weck
mesh_terms: D064790:Clinical Laboratory Services / Q000592:standards; D015723:Gene Library; D005820:Genetic Testing / Q000379:methods* / Q000592:standards; D006801:Humans; D059021:Laboratory Proficiency Testing / Q000379:methods* / Q000592:standards; D017421:Sequence Analysis / Q000379:methods / Q000592:standards; D054928:Validation Studies as Topic; D057188:Workflow