title: Bile duct evaluation of potential living liver donors with Gd-EOB-DTPA enhanced MR cholangiography: Single-dose, double dose or half-dose contrast enhanced imaging.
abstract: BACKGROUND
  Detailed knowledge of the biliary anatomy is essential to avoid complications in living donor liver transplantation. The aim of this study was to determine the optimal dosage of Gd-EOB-DTPA for contrast-enhanced magnetic resonance cholangiography (ce-MRC) with reference to contrast-enhanced CT cholangiography (ce-CTC).
  
  
  METHODS
  30 potential living liver donors (PLLD) underwent both ce-CTC and ce-MRC. Ten candidates each received single, double or half-dose Gd-EOB-DTPA. Ce-MRC images with and without inversion recovery pulses (T1w±IR) were acquired 20-30min after intravenous contrast injection. Image data was quantitatively and qualitatively reviewed by two radiologists based on a on a 5-point scale. Data sets were compared using a Mann-Whitney-U-test or Wilcoxon-rank-sum-test. Kappa values were also calculated.
  
  
  RESULTS
  All image series provided sufficient diagnostic information both showing normal biliary anatomy and variant bile ducts. Ce-CTC showed statistically significant better results compared to all ce-MRC data sets. T1w MRC with single dose Gd-EOB-DTPA proved to be superior to half and double dose in subjective and objective evaluation without a statistically significant difference.
  
  
  CONCLUSIONS
  Ce-MRC is at any dosage inferior to ce-CTC. As far as preoperative planning of bile duct surgery is focused on the central biliary anatomy, ce-MRC can replace harmful ce-CTC strategies, anyway. Best results were seen with single dose GD-EOB-DTPA on T1w MRC+IR.
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany. Electronic address: Sonja.Kinner@uni-due.de.
authors.forename: Sonja
authors.initials: S
authors.lastname: Kinner
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
authors.forename: Verena
authors.initials: V
authors.lastname: Steinweg
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany; Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Maderwald
authors.affiliation: Department of General Surgery, University Hospital Essen, Germany.
authors.forename: Arnold
authors.initials: A
authors.lastname: Radtke
authors.affiliation: Department of General Surgery, University Hospital Essen, Germany.
authors.forename: Georgios
authors.initials: G
authors.lastname: Sotiropoulos
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Forsting
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Schroeder
mesh_terms: D000328:Adult; D001652:Bile Ducts / Q000002:abnormalities* / Q000473:pathology* / Q000637:transplantation; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods; D004305:Dose-Response Relationship, Drug; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
keywords: Gd-EOB-DTPA,; Living liver transplantation; MR cholangiography