title: What determines human body odour?
abstract: Human body odour and earwax type are genetically dependent on a single-nucleotide polymorphism (SNP) located in the ABCC11 gene. So far, it still remains to be clear how SNP in the ABCC11 gene is associated with human malodour. In a recent issue of Experimental Dermatology, Baumann et al. propose one of the underlying molecular pathways. Although one of the amino acid conjugated of the odorants, Cys-Gly-3-methyl-3-sulfanylhexanol (3M3SH), was not taken up by the transporter ABCC11, glutathione conjugate of 3MSH (SG-3MSH) was transported by ABCC11. Moreover, SG-3MSH was processed to 3M3SH by γ-glutamyl-transferase 1 (GGT1), which was abundantly expressed in apocrine sweat glands. These findings may pave a way for the pharmacogenetics of human body odour and the development of innovative deodorant products.
authors.affiliation: Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Hamada
authors.forename: Sanehito
authors.initials: S
authors.lastname: Haruyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Kayo
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Kana
authors.initials: K
authors.lastname: Hiromasa
authors.forename: Manabu
authors.initials: M
authors.lastname: Yoshioka
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nishio
authors.forename: Motonobu
authors.initials: M
authors.lastname: Nakamura
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D001692:Biological Transport; D005978:Glutathione / Q000378:metabolism; D000441:Hexanols / Q000737:chemistry; D006801:Humans; D009812:Odorants / Q000032:analysis*; D020641:Polymorphism, Single Nucleotide; D013545:Sweat Glands / Q000737:chemistry; D005723:gamma-Glutamyltransferase / Q000235:genetics
chemical_list: C435500:ABCC11 protein, human; D018528:ATP-Binding Cassette Transporters; D000441:Hexanols; D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human; D005978:Glutathione
keywords: 3-methyl-3-sulfanylhexanol; ABCC11; GGT1; odor