title: [Overall logarithmic index for the characterization of adaptation and regulatory systems straining under chronic action of extreme environmental factors].
abstract: The article advertizes some optional capabilities of the overall logarithmic index as an integral parameter for quantifying adaptation processes triggered by chronic exposure to stress factors of varying intensity. Consideration is given to the principles of damage formation in different systems of organism with time and subsequent compensatory processes depending on the level of regulation system straining, rate of functional potential depletion, probability of remote consequences such as early aging, increased risk of lethality and reduction of the mean remaining life expectancy. The overall logarithmic index will be used to analyze the transition from normal to active insufficient adaptation, and possible adaptation failure because of a drastic decline of organism resistance. In fact, an attempt was made to use the index to quantify adaptation cost, loss of resistance, and possible increase of the risk of remote consequences.
authors.forename: A V
authors.initials: AV
authors.lastname: Shafirkin
authors.forename: A L
authors.initials: AL
authors.lastname: Vasin
authors.forename: A S
authors.initials: AS
authors.lastname: Shtemberg
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology*; D000375:Aging / Q000502:physiology; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D008017:Life Expectancy; D013312:Stress, Physiological / Q000502:physiology*; D013997:Time Factors