title: Survival study and clinicopathological evaluation of trichilemmal carcinoma.
abstract: Trichilemmal carcinoma (TC) is a rare malignancy, commonly located on the scalp, forehead and neck, trunk or the upper extremities. The aim of this study was to investigate the clinicopathological characteristics and prognostic factors of TC, and to determine an optimal treatment strategy for these patients. Consecutive patients who were admitted to the Sun Yat-sen University Cancer Center between 1998 and 2012 were included in this retrospective study. The key prognostic factors affecting survival were lymph node metastasis and surgery margin. Multivariate analysis demonstrated that there was no risk factor for patient survival. Surgery margin and lymph node metastasis were the prognostic factors that influenced the treatment outcome. Simple excision with 1 cm margins is safe, cost-effective and effective for the treatment of TC. Additionally, postoperative follow-up of the patient in order to facilitate early diagnosis of recurrence and distant metastasis is necessary. Systemic chemotherapy should be considered in the case of patients with distant metastases.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital Sun Yat-sen University, Guangzhou, Guangdong 510630;
authors.forename: Shi-Min
authors.initials: SM
authors.lastname: Zhuang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital Sun Yat-sen University, Guangzhou, Guangdong 510630;
authors.forename: Ge-Hua
authors.initials: GH
authors.lastname: Zhang
authors.affiliation: Department of Head and Neck Surgery and State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Wen-Kuan
authors.initials: WK
authors.lastname: Chen
authors.affiliation: Department of Head and Neck Surgery and State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Chen
authors.affiliation: Department of Head and Neck Surgery and State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Wang
authors.affiliation: Department of Head and Neck Surgery and State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Huan
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Head and Neck Surgery and State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Ming
authors.initials: M
authors.lastname: Song
keywords: chemotherapy; locoregional recurrence; lymph nodes metastasis; treatment strategy; trichilemmal carcinoma