title: [Total aminothioles of rat plasma under intraperitoneal and subcutaneous introduction of homocysteine].
abstract: In the presented work a variation of total aminothiols (cysteine, glutathione, cysteinylglycine and homocysteine) in blood plasma have been shown at modelling hyperhomocysteinemia by daily intraperitoneal (0.6 mkmol/g body weight) and subcutaneous (0.12 mkmol/g body weight) introduction of homocysteine. During two weeks of the intraperitoneal introduction a significant concentration growth (from -40 to 180 mkM) of cysteine was observed. We also observed a moderate change of concentration levels for glutathione (from 10-15 to 30 mkM) and cysteinylglycine (from 1,5 to 4,5 mkM). The homocysteine level has decreased from 300 to 200-250 mkM at second week of experiments. Experimental results with subcutaneous introduction were similar. In this case a stable homocysteine level (-70 mkM) and increase of cysteine level (to 60 mkM) was observed at second week. These data reflect dose-depended processes of organism adaptation to hyperhomocysteinemia, i.e. reinforced capability for homocysteine metabolism and at the same time retention low glutathione level which correlates with hyperhomocysteinemia degree and duration.
authors.forename: A V
authors.initials: AV
authors.lastname: Ivanov
authors.forename: A A
authors.initials: AA
authors.lastname: Moskovtsev
authors.forename: E E
authors.initials: EE
authors.lastname: Martynova
authors.forename: G D
authors.initials: GD
authors.lastname: Savina
authors.forename: B P
authors.initials: BP
authors.lastname: Luzyanin
authors.forename: A A
authors.initials: AA
authors.lastname: Kubatiev
mesh_terms: D000818:Animals; D003545:Cysteine / Q000097:blood*; D004151:Dipeptides / Q000097:blood*; D005978:Glutathione / Q000097:blood*; D006710:Homocysteine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004151:Dipeptides; D006710:Homocysteine; C028505:cysteinylglycine; D005978:Glutathione; D003545:Cysteine