title: Phenylthiocarbamate or N-carbothiophenyl group chemistry in peptide synthesis and bioconjugation.
abstract: The design of novel chemoselective and site-specific ligation methods provides new tools for obtaining complex scaffolds, peptidomimetics, and peptide conjugates. The chemistry of the N-phenylthiocarbonyl group has led to several developments in peptide ligation chemistry and peptide bioconjugation during the last 10 years. The aim of this review is to provide an overview of this emerging field.
authors.affiliation: UMR CNRS 8161 , F-59021 Lille, France.
authors.forename: Oleg
authors.initials: O
authors.lastname: Melnyk
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ollivier
authors.forename: Soizic
authors.initials: S
authors.lastname: Besret
authors.forename: Patricia
authors.initials: P
authors.lastname: Melnyk
mesh_terms: D060326:Chemistry Techniques, Synthetic; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D057786:Peptidomimetics; D048448:Phenylcarbamates / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013859:Thiocarbamates / Q000737:chemistry*
chemical_list: D010455:Peptides; D057786:Peptidomimetics; D048448:Phenylcarbamates; D013438:Sulfhydryl Compounds; D013859:Thiocarbamates; C419359:phenylthiocarbamate