title: Rotavirus surveillance in urban and rural areas of Niger, April 2010-March 2012.
abstract: Knowledge of rotavirus epidemiology is necessary to make informed decisions about vaccine introduction and to evaluate vaccine impact. During April 2010-March 2012, rotavirus surveillance was conducted among 9,745 children <5 years of age in 14 hospitals/health centers in Niger, where rotavirus vaccine has not been introduced. Study participants had acute watery diarrhea and moderate to severe dehydration, and 20% of the children were enrolled in a nutrition program. Of the 9,745 children, 30.6% were rotavirus positive. Genotyping of a subset of positive samples showed a variety of genotypes during the first year, although G2P[4] predominated. G12 genotypes, including G12P[8], which has emerged as a predominant strain in western Africa, represented >80% of isolates during the second year. Hospitalization and death rates and severe dehydration among rotavirus case-patients did not differ during the 2 years. The emergence of G12P[8] warrants close attention to the characteristics of associated epidemics and possible prevention measures.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Page
authors.forename: Viviane
authors.initials: V
authors.lastname: Jusot
authors.forename: Abdoul-Aziz
authors.initials: AA
authors.lastname: Mamaty
authors.forename: Lagare
authors.initials: L
authors.lastname: Adamou
authors.forename: Jérôme
authors.initials: J
authors.lastname: Kaplon
authors.forename: Pierre
authors.initials: P
authors.lastname: Pothier
authors.forename: Ali
authors.initials: A
authors.lastname: Djibo
authors.forename: Mahamane L
authors.initials: ML
authors.lastname: Manzo
authors.forename: Brahima
authors.initials: B
authors.lastname: Toure
authors.forename: Céline
authors.initials: C
authors.lastname: Langendorf
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Collard
authors.forename: Rebecca F
authors.initials: RF
authors.lastname: Grais
mesh_terms: D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005838:Genotype; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009548:Niger / Q000453:epidemiology; D012401:Rotavirus / Q000235:genetics*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D022243:Rotavirus Vaccines
keywords: Africa; Niger; developing countries; diarrheal diseases; gastroenteritis; genotyping; malnutrition; rotavirus; rotavirus strain G12P[8]; surveillance; viruses