title: The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging.
abstract: Evidence exists for late-life depression (LLD) as both a prodrome of and risk factor for Alzheimer׳s disease (AD). The underlying neurobiological mechanisms are poorly understood. Impaired peripheral glucose metabolism may explain the association between depression and AD given the connection between type 2 diabetes mellitus with both depression and AD. Positron emission tomography (PET) measures of cerebral glucose metabolism are sensitive to detecting changes in neural circuitry in LLD and AD. Fasting serum glucose (FSG) in non-diabetic young (YC; n=20) and elderly controls (EC; n=12) and LLD patients (n=16) was correlated with PET scans of cerebral glucose metabolism on a voxel-wise basis. The negative correlations were more extensive in EC versus YC and in LLD patients versus EC. Increased FSG correlated with decreased cerebral glucose metabolism in LLD patients to a greater extent than in EC in heteromodal association cortices involved in mood symptoms and cognitive deficits observed in LLD and dementia. Negative correlations in YC were observed in sensory and motor regions. Understanding the neurobiological consequences of diabetes and associated conditions will have substantial public health significance given that this is a modifiable risk factor for which prevention strategies could have an important impact on lowering dementia risk.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Marano
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
authors.forename: Clifford I
authors.initials: CI
authors.lastname: Workman
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Lyman
authors.affiliation: Department of Geriatric Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA.
authors.forename: Elisse
authors.initials: E
authors.lastname: Kramer
authors.affiliation: Department of Geriatric Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA.
authors.forename: Carol R
authors.initials: CR
authors.lastname: Hermann
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore - Long Island Jewish Health System, Manhasset, NY 11030, USA.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore - Long Island Jewish Health System, Manhasset, NY 11030, USA.
authors.forename: Vijay
authors.initials: V
authors.lastname: Dhawan
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore - Long Island Jewish Health System, Manhasset, NY 11030, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Chaly
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore - Long Island Jewish Health System, Manhasset, NY 11030, USA.
authors.forename: David
authors.initials: D
authors.lastname: Eidelberg
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. Electronic address: gsmith95@jhmi.edu.
authors.forename: Gwenn S
authors.initials: GS
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism*; D005215:Fasting / Q000097:blood / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D005947:Glucose
keywords: FDG PET; Fasting blood glucose; Insulin resistance; Late-life depression; Normal aging