title: Impact of ectopic pregnancy for reproductive prognosis in next generation.
abstract: The impact of an ectopic pregnancy in the next generation is unknown. Our aim was to compare reproductive outcomes in daughters of women with and without ectopic pregnancy. Designed as a historical prospective controlled cohort study with data collected in four Danish registries from 1977-2009, women with ectopic pregnancy during 1977-1982 were age-matched to women without ectopic pregnancy. Daughters of these two cohorts were followed until 2009. We compared 5126 daughters of women with ectopic pregnancy with 19 928 daughters of women without ectopic pregnancy. The daughters of women with ectopic pregnancy had a 1.5-fold (95% confidence interval 1.2-1.9) increased risk of ectopic pregnancy, while for deliveries this was 1.0 (1.0-1.1), for miscarriages 1.1 (1.0-1.2), and for induced abortions 1.3 (1.2-1.4). Daughters of mothers with ectopic pregnancy have a 50% higher risk of ectopic pregnancy than daughters of women without an ectopic pregnancy, but a normal delivery rate.
authors.affiliation: Gynecological Clinic 4232, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Line Lund
authors.initials: LL
authors.lastname: Kårhus
authors.forename: Pia
authors.initials: P
authors.lastname: Egerup
authors.forename: Charlotte Wessel
authors.initials: CW
authors.lastname: Skovlund
authors.forename: Øjvind
authors.initials: Ø
authors.lastname: Lidegaard
mesh_terms: D000028:Abortion, Induced / Q000706:statistics & numerical data*; D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D009679:Nuclear Family; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D011271:Pregnancy, Ectopic / Q000175:diagnosis* / Q000453:epidemiology* / Q000601:surgery; D011379:Prognosis; D011446:Prospective Studies; D012042:Registries; D043762:Reproductive Behavior; D018570:Risk Assessment; D012307:Risk Factors
keywords: Ectopic pregnancy; fecundity; heredity; inter-generational; reproduction