title: Hydrogen peroxide signaling in vascular endothelial cells.
abstract: Redox signaling is implicated in different physiological and pathological events in the vasculature. Among the different reactive oxygen species, hydrogen peroxide (H2O2) is a very good candidate to perform functions as an intracellular messenger in the regulation of several biological events. In this review, we summarize the main physiological sources of H2O2 in the endothelium and the molecular mechanisms by which it is able to act as a signaling mediator in the vasculature.
authors.affiliation: Centro de Biología Molecular 'Severo Ochoa' CSIC-UAM, Campus Universidad Autónoma, Nicolás Cabrera 1, Madrid E-28049, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Bretón-Romero
authors.affiliation: Centro de Biología Molecular 'Severo Ochoa' CSIC-UAM, Campus Universidad Autónoma, Nicolás Cabrera 1, Madrid E-28049, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Lamas
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism; D002455:Cell Division; D042783:Endothelial Cells / Q000378:metabolism*; D018056:Hemorheology; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D019255:NADPH Oxidases / Q000378:metabolism; D018919:Neovascularization, Physiologic / Q000502:physiology; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010088:Oxidoreductases / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*; D014968:Xanthine Dehydrogenase / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D052250:Nitric Oxide Synthase Type III; D014968:Xanthine Dehydrogenase; D019255:NADPH Oxidases; D011494:Protein Kinases
keywords: Endothelium; Hydrogen peroxide; Redox signaling; Vasodilation