title: Meta-analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility.
abstract: Testing for genetic risk associations between Factor V Leiden (FVL) and the osteonecrosis of femoral head (ONFH) is common, however, inconsistent results have been previously obtained. To summarize results on the association of FVL mutation polymorphism with ONFH in various populations and to calculate the overall genetic risk factors, we performed a search of electronic databases including PubMed, Elsevier Science Direct, Chinese National Knowledge Infrastructure and the Chinese Biomedical Database to identify published studies correlating the FVL mutation with ONFH. Statistical analysis was performed using Review Manager (RevMan) version 5.0 and Stata statistical software (version 10). We identified 57 titles and included 7 studies comprising 481 cases and 867 controls in this meta-analysis. The groups were pooled, and a significant association between FVL mutation and increased ONFH was found (OR=4.55, 95% CI, 2.75-7.52, P<0.00001). This meta-analysis demonstrated that FVL plays an important role in non-Asian populations. Large sample studies including different ethnic groups and age- and gender-matched groups, as well as multiple gene polymorphism detection should be considered to clarify the association of FVL mutation polymorphism and ONFH susceptibility in the future.
authors.affiliation: Department of Orthopedic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China.
authors.forename: Xifu
authors.initials: X
authors.lastname: Shang
authors.affiliation: Department of Orthopedic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China.
authors.forename: Zhengliang
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Department of Orthopedic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China.
authors.forename: Xu
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Orthopedic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Hu
authors.affiliation: Department of Orthopedic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China.
authors.forename: Qichun
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Orthopedic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China.
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Zhang
keywords: Factor V Leiden mutation; meta-analysis; osteonecrosis of femoral head; polymorphism