title: Humanized mouse models in transplantation research.
abstract: The interest in the use of humanized mouse models for research topics like Graft versus Host Disease (GvHD), allograft studies and other studies to the human immune system is growing. The design of these models is still improving and enables even more complicated studies to these topics. For researchers it can be difficult to choose the best option from the current pool of available models. The decision will depend on which hypothesis needs to be tested, in which field of interest, and therefore 'the best model' will differ from one to another. In this review, we provide a guide to the most common available humanized mouse models, with regards to different mouse strains, transplantation material, transplantation techniques, pre- and post-conditioning and references to advantages and disadvantages. Also, an evaluation of experiences with humanized mouse models in studies on GvHD and allograft rejection is provided.
authors.affiliation: Department of Pathology, University Medical Centre Utrecht, PO box 85500, 3508 GA Utrecht, The Netherlands.
authors.forename: Marieke
authors.initials: M
authors.lastname: Hogenes
authors.affiliation: Department of Pathology, University Medical Centre Utrecht, PO box 85500, 3508 GA Utrecht, The Netherlands.
authors.forename: Manon
authors.initials: M
authors.lastname: Huibers
authors.affiliation: Department of Pathology, University Medical Centre Utrecht, PO box 85500, 3508 GA Utrecht, The Netherlands.
authors.forename: Chantal
authors.initials: C
authors.lastname: Kroone
authors.affiliation: Department of Pathology, University Medical Centre Utrecht, PO box 85500, 3508 GA Utrecht, The Netherlands. Electronic address: r.deweger@umcutrecht.nl.
authors.forename: Roel
authors.initials: R
authors.lastname: de Weger
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006084:Graft Rejection / Q000276:immunology*; D006086:Graft vs Host Disease / Q000276:immunology*; D006801:Humans; D051379:Mice; D057170:Translational Research, Biomedical; D014181:Transplantation Immunology