title: Molecular typing of canine distemper virus strains reveals the presence of a new genetic variant in South America.
abstract: Canine distemper virus (CDV, Paramyxoviridae, Morbillivirus) is the causative agent of a severe infectious disease affecting terrestrial and marine carnivores worldwide. Phylogenetic relationships and the genetic variability of the hemagglutinin (H) protein and the fusion protein signal-peptide (Fsp) allow for the classification of field strains into genetic lineages. Currently, there are nine CDV lineages worldwide, two of them co-circulating in South America. Using the Fsp-coding region, we analyzed the genetic variability of strains from Uruguay, Brazil, and Ecuador, and compared them with those described previously in South America and other geographical areas. The results revealed that the Brazilian and Uruguayan strains belong to the already described South America lineage (EU1/SA1), whereas the Ecuadorian strains cluster in a new clade, here named South America 3, which may represent the third CDV lineage described in South America.
authors.affiliation: Sección Genética Evolutiva, Instituto de Biología, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Sarute
authors.forename: Ruben
authors.initials: R
authors.lastname: Pérez
authors.forename: Jaime
authors.initials: J
authors.lastname: Aldaz
authors.forename: Amauri A
authors.initials: AA
authors.lastname: Alfieri
authors.forename: Alice F
authors.initials: AF
authors.lastname: Alfieri
authors.forename: Daniela
authors.initials: D
authors.lastname: Name
authors.forename: Jessika
authors.initials: J
authors.lastname: Llanes
authors.forename: Martín
authors.initials: M
authors.lastname: Hernández
authors.forename: Lourdes
authors.initials: L
authors.lastname: Francia
authors.forename: Yanina
authors.initials: Y
authors.lastname: Panzera
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004216:Distemper / Q000821:virology*; D004217:Distemper Virus, Canine / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D004285:Dogs; D014644:Genetic Variation; D006389:Hemagglutinins, Viral / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D058889:Molecular Typing; D010802:Phylogeny; D016415:Sequence Alignment; D013020:South America
chemical_list: D006389:Hemagglutinins, Viral