title: Promising use of minocycline augmentation with clozapine in treatment-resistant schizophrenia.
abstract: Treatment-resistant schizophrenia is a major health problem in the UK with the majority of patients treated with clozapine. In up to 70% of cases there is only a partial response to clozapine with continuing refractory symptoms. We describe two cases in a UK mental health service where minocycline was found to be useful and well tolerated as an augmentation agent with clozapine in the improvement of previously resistant positive and negative symptoms.
authors.affiliation: Ashworth Hospital, Maghull, UK Inti.Qurashi@merseycare.nhs.uk.
authors.forename: I
authors.initials: I
authors.lastname: Qurashi
authors.affiliation: Ashworth Hospital, Maghull, UK.
authors.forename: J D
authors.initials: JD
authors.lastname: Collins
authors.affiliation: Lancashire Care NHS Trust, Preston, UK University of Manchester, Manchester, UK.
authors.forename: I B
authors.initials: IB
authors.lastname: Chaudhry
authors.affiliation: University of Manchester, Manchester, UK.
authors.forename: N
authors.initials: N
authors.lastname: Husain
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008911:Minocycline / Q000627:therapeutic use*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D008911:Minocycline; D003024:Clozapine
keywords: Minocycline; clozapine; treatment-resistant schizophrenia