title: Prevalence and socio-demographic factors associated with non-protective immunity against tetanus among high school adolescents girls in Nigeria.
abstract: BACKGROUND
  The low uptake of tetanus vaccine and its resultant high burden of tetanus in Nigeria suggest the need to improve routine and booster vaccination in children and adolescents. However, epidemiological evidence for vaccination in the adolescent age group needed for effective strategy and policy formulation is lacking. This study was carried out to determine the prevalence of protective immunity against tetanus and to identify risk factors for non-protective immunity among schooling adolescents.
  
  
  METHODS
  Using a three-stage sampling technique, 851 female adolescents were randomly selected from secondary schools in Ibadan, Nigeria. A pre-tested questionnaire was used to obtain data on demographic and socio-economic characteristics and history of tetanus vaccination. An immuno-chromatographic rapid test kit, "Tetanos Quick Stick" was used to test specific anti-tetanus antibody protective level in venous blood samples. Descriptive statistics, Chi-square and logistic regression analyses were done with level of significance set at p = 0.05.
  
  
  RESULTS
  Mean age of participants was 14.3 ± 1.9 years. Seroprevalence of protective immunity against tetanus was 38.1% and it significantly decreased with increasing age. More adolescents in public (65.4%) than private (44.7%) schools had non-protective level of immunity. A significantly increasing trend in the risk of non-protective immunity was observed with decreasing level of mothers' education. Also, the Odds of non-protective level of immunity was significantly higher in public than private schools (OR = 2.14; 95% CI =1.39, 3.20) but lower among adolescents who had history of recent tetanus toxoid injection than those who did not (OR = 0.11 95% CI = 0.09, 0.22). However, no significant association was found between protective immunity against tetanus and parents' marital status as well as family size.
  
  
  CONCLUSIONS
  Protective immunity against tetanus among female adolescents was poor, more so in public schools and those who had not received vaccination a year prior to the study. Policy-makers need to consider the inclusion of immunization against tetanus in the school health programme.
authors.affiliation: Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria. beorimadegun@yahoo.com.
authors.forename: Adebola E
authors.initials: AE
authors.lastname: Orimadegun
authors.forename: Akinlolu A
authors.initials: AA
authors.lastname: Adepoju
authors.forename: Olusegun O
authors.initials: OO
authors.lastname: Akinyinka
mesh_terms: D000293:Adolescent; D003017:Clostridium tetani / Q000276:immunology; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012574:Schools; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors; D013742:Tetanus / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D013745:Tetanus Toxoid / Q000494:pharmacology / Q000600:supply & distribution*
chemical_list: D013745:Tetanus Toxoid