title: Association of IP-10 gene polymorphism with susceptibility to Enterovirus 71 infection.
abstract: Enterovirus 71 (EV71) often causes large outbreaks of diseases among children worldwide and its pathogenesis remains unclear. The aim of the present study was to investigate the association between interferon-inducible protein 10 (IP-10) polymorphism in children with EV71 infection. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to analyze the gene polymorphisms of IP-10 (-1596C/T) in 58 EV71-infected and 48 control patients. The results showed that in EV71-infected patients the frequency of carrying CT + TT genotype and T allele is 10.3 and 6.0%, respectively, which is significantly lower than that of the controls (29.2 and 15.6%, respectively). Individuals with T allele had a lower risk of EV71 infection [odds ratio (OR) = 0.35, 95% confidence interval (CI), 0.13-0.89]. The results of this study indicated that -1596T allele for the IP-10 gene may be a beneficial factor for EV71 infection.
authors.affiliation: Department of Pediatrics, The Affiliated Hospital of Qingdao Hiser Medical Center of Qingdao University;
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Pediatrics, The Affiliated Hospital of the Medical School of Qingdao University, Qingdao, Shandong 266100, P.R. China.
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, The Affiliated Hospital of the Medical School of Qingdao University, Qingdao, Shandong 266100, P.R. China.
authors.forename: Tie-Gang
authors.initials: TG
authors.lastname: Lv
authors.affiliation: Department of Pediatrics, The Affiliated Hospital of the Medical School of Qingdao University, Qingdao, Shandong 266100, P.R. China.
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, The Affiliated Hospital of the Medical School of Qingdao University, Qingdao, Shandong 266100, P.R. China.
authors.forename: Zong-Bo
authors.initials: ZB
authors.lastname: Chen
keywords: Enterovirus 71; interferon-inducible protein 10; polymorphism; single nucleotide