title: [Clinical-anamnestic and molecular-genetic factors in different forms of hypertension and its relationship to course and pregnancy outcomes].
abstract: OBJECTIVE
  To assess of the relationship of clinical and molecular genetic factors in the course and outcome of pregnancy in different forms of hypertension in pregnant women.
  
  
  METHODS
  A total of 125 pregnant women who were divided into the following groups: with chronic hypertension (n = 45), with gestational hypertension (n = 20), with pre-eclampsia (n = 10), superimposed preeclampsia upon chronic hypertension (n = 15) and 35 women without hypertension in control group.
  
  
  RESULTS
  In pregnant women with chronic hypertension and superimposed preeclampsia upon chronic hypertension were observed higher incidence of overweight and obesity, smoking before pregnancy and family history of hypertension and thrombosis, the course and outcomes of pregnancy characterized by higher frequency of obstetric complications, higher frequency of polymorphisms of genes identified the renin-angiotensin system, folate cycle and endothelial function.
  
  
  CONCLUSIONS
  Molecular-genetic factors, combined with the factors of cardiovascular risk may make some contribution to the phenotypic realization of pregnancy complications and adverse pregnancy outcomes in pregnant women with different forms of hypertension.
authors.forename: V S
authors.initials: VS
authors.lastname: Chulkov
authors.forename: N K
authors.initials: NK
authors.lastname: Vereina
authors.forename: S P
authors.initials: SP
authors.lastname: Sinitsyn
authors.forename: V F
authors.initials: VF
authors.lastname: Dolgushina
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D008487:Medical History Taking / Q000379:methods*; D008875:Middle Aged; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D005819:Genetic Markers