title: Transperitoneal approach versus retroperitoneal approach: a meta-analysis of laparoscopic partial nephrectomy for renal cell carcinoma.
abstract: OBJECTIVE
  To compare the efficiency and safety of the transperitoneal approaches with retroperitoneal approaches in laparoscopic partial nephrectomy for renal cell carcinoma and provide evidence-based medicine support for clinical treatment.
  
  
  METHODS
  A systematic computer search of PUBMED, EMBASE, and the Cochrane Library was executed to identify retrospective observational and prospective randomized controlled trials studies that compared the outcomes of the two approaches in laparoscopic partial nephrectomy. Two reviewers independently screened, extracted, and evaluated the included studies and executed statistical analysis by using software STATA 12.0. Outcomes of interest included perioperative and postoperative variables, surgical complications and oncological variables.
  
  
  RESULTS
  There were 8 studies assessed transperitoneal laparoscopic partial nephrectomy (TLPN) versus retroperitoneal laparoscopic partial nephrectomy (RLPN) were included. RLPN had a shorter operating time (SMD = 1.001,95%confidence interval[CI] 0.609-1.393,P<0.001), a lower estimated blood loss (SMD = 0.403,95%CI 0.015-0.791,P = 0.042) and a shorter length of hospital stay (WMD = 0.936 DAYS,95%CI 0.609-1.263,P<0.001) than TLPN. There were no significant differences between the transperitoneal and retroperitoneal approaches in other outcomes of interest.
  
  
  CONCLUSIONS
  This meta-analysis indicates that, in appropriately selected patients, especially patients with intraperitoneal procedures history or posteriorly located renal tumors, the RLPN can shorten the operation time, reduce the estimated blood loss and shorten the length of hospital stay. RLPN may be equally safe and be faster compared with the TLPN.
authors.affiliation: Department of Urinary Surgery, First Affiliated Hospital, Harbin Medical University, NanGang District, Harbin, Heilongjiang Province China.
authors.forename: Tong
authors.initials: T
authors.lastname: Ren
authors.affiliation: Department of Biostatistics, School of Public Health, Harbin Medical University, Nangang District, Harbin, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Health Economics, School of Public Health, Harbin Medical University, Nangang District, Harbin, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Urinary Surgery, First Affiliated Hospital, Harbin Medical University, NanGang District, Harbin, Heilongjiang Province China.
authors.forename: Shaobin
authors.initials: S
authors.lastname: Ni
authors.affiliation: Department of Urinary Surgery, First Affiliated Hospital, Harbin Medical University, NanGang District, Harbin, Heilongjiang Province China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Urinary Surgery, First Affiliated Hospital, Harbin Medical University, NanGang District, Harbin, Heilongjiang Province China.
authors.forename: Changgang
authors.initials: C
authors.lastname: Guo
authors.affiliation: Department of Urinary Surgery, First Affiliated Hospital, Harbin Medical University, NanGang District, Harbin, Heilongjiang Province China.
authors.forename: Minghua
authors.initials: M
authors.lastname: Ren
mesh_terms: D016063:Blood Loss, Surgical; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000601:surgery*; D019317:Evidence-Based Medicine; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery*; D010535:Laparoscopy / Q000379:methods; D007902:Length of Stay; D009392:Nephrectomy / Q000009:adverse effects / Q000379:methods*; D061646:Operative Time; D018579:Patient Selection; D011183:Postoperative Complications; D011446:Prospective Studies; D012187:Retroperitoneal Space; D012189:Retrospective Studies; D016896:Treatment Outcome