title: Topical tacrolimus and periodontal therapy in the management of a case of oral chronic GVHD characterized by specific gingival localization.
abstract: Background. Chronic graft versus host disease (cGVHD) is a complication following bone marrow transplantation. The oral lesions are difficult to control with a systemic pharmacological therapy. Case Description. A 63-year-old female patient, who underwent an allogeniec transplantation for acute myeloid leukemia, developed a chronic oral and cutaneous GVHD. The patient was treated with topical tacrolimus 0.1%, twice daily for two months, and underwent a protocol of oral hygiene characterized by 3 appointments of scaling, root planning, and daily oral hygiene instructions. The patient showed marked resolution of gingival lesions and a significant improvement of related pain and gingival inflammatory indexes. Clinical Implications. This case report suggests that treatment with topical tacrolimus and professional oral hygiene may be helpful in the management of chronic oral GVHD with severe gingival involvement.
authors.affiliation: Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Conrotto
authors.affiliation: Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Broccoletti
authors.affiliation: Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Carcieri
authors.affiliation: Division of Haematology, Azienda Ospedaliera Città della Salute e della Scienza, University of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Giaccone
authors.affiliation: Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy.
authors.forename: Paolo G
authors.initials: PG
authors.lastname: Arduino