title: [Experience with outpatient treatment for thromboses and thrombophilias].
abstract: OBJECTIVE
  To evaluate the efficiency of diagnosis and treatment of thromboses in patients with thrombophilia in an outpatient setting.
  
  
  METHODS
  One hundred and seventy-two patients with different forms of thrombophilic states were examined. One hundred and thirty-two patients were found to have genetic mutations, of them 125 patients had multiple mutations. Thromboses were diagnosed in 130 patients with genetic disorders.
  
  
  RESULTS
  The most common laboratory markers of thrombophilias were hyperhomocysteinemia (55%), sticky platelet syndrome (41%), and laboratory findings of antiphospholipid syndrome. Thrombogenic mutations, such as plasminogen activator plasminogen inhibitor-1 (73%), methylene tetrahydrofolate reductase (60%), platelet glycoprotein 1a receptors (50%), and fibrinogen (42%), were most often diagnosed. The efficiency of treatment was shown to largely depend on the duration of an initial thrombotic process.
  
  
  CONCLUSIONS
  Outpatient treatment for thromboses is more economical and comfortable for patients. To avoid hospital admissions, it is necessary to time detect the disease and to start its treatment as soon as possible. The concurrent use of ultrasonography, genetic and laboratory diagnostic methods accelerates the identification and localization of the pathology, which facilitates its treatment and frequently rules out the need for patient hospitalization.
authors.forename: S A
authors.initials: SA
authors.lastname: Vasil'ev
authors.forename: V L
authors.initials: VL
authors.lastname: Vinogradov
authors.forename: É G
authors.initials: ÉG
authors.lastname: Gemdzhian
authors.forename: E B
authors.initials: EB
authors.lastname: Orel
authors.forename: A A
authors.initials: AA
authors.lastname: Shevelev
authors.forename: O V
authors.initials: OV
authors.lastname: Margolin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010045:Outpatients / Q000706:statistics & numerical data; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D013927:Thrombosis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers