title: Dynamic changes of cardiovascular regulating factors in rats after aerobic exhaustive exercise.
abstract: OBJECTIVE
  To study the changes of cardiovascular regulating factors in rats during recovery of aerobic exhaustive exercise.
  
  
  METHODS
  Sixty male Wistar rats were randomly divided into control group, 1 h-exercise group, 3 h-exercise group, exhausted group, 2 h-recovery group and 12 h-recovery group. The rats were killed at corresponding times for each group after an 8-week-long treadmill training, and the levels of NO, ET, ANP and TXB2 in plasma were measured in each group.
  
  
  RESULTS
  NO/ET ratio of 1 h-exercise group was significantly higher than that in control group (P < 0.01), while it was significantly decreased in 3 h-exercise group and exhausted group (P < 0.05). ANP contents in rat plasma were significantly higher in 3 h-exercise group, exhausted group and 2 h-recovery group than that in control group (P < 0.05 or P < 0.01). The concentration of TXB2 in plasma was significantly increased in 3 h-exercise group, exhausted group and 2 h-recovery group (P < 0.05).
  
  
  CONCLUSIONS
  Changes in cardiovascular regulating factors after exhaustive exercise may lead to deficiency of coronary circulation blood/oxygen supply, which may cause exercise-induced fatigue.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.forename: Hong-Zhen
authors.initials: HZ
authors.lastname: Liu
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D002319:Cardiovascular System / Q000503:physiopathology*; D016232:Endothelins / Q000097:blood; D005080:Exercise Test; D005221:Fatigue / Q000097:blood*; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D016232:Endothelins; D009569:Nitric Oxide; D013929:Thromboxane B2; D009320:Atrial Natriuretic Factor