title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-year-old children in Vietnam.
abstract: Dioxin levels in the breast milk of mothers residing near a contaminated former airbase in Vietnam remain much higher than in unsprayed areas, suggesting high perinatal dioxin exposure for their infants. The present study investigated the association of perinatal dioxin exposure with autistic traits in 153 3-year-old children living in a contaminated area in Vietnam. The children were followed up from birth using the neurodevelopmental battery Bayley-III. The high-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposed groups (⩾3.5 pg per g fat) showed significantly higher Autism Spectrum Rating Scale (ASRS) scores for both boys and girls than the mild-TCDD exposed groups, without differences in neurodevelopmental scores. In contrast, the high total dioxin-exposed group, indicated by polychlorinated dibenzo-p-dioxins/furans (PCDDs/Fs)--the toxic equivalents (TEQ) levels⩾17.9 pg-TEQ per g fat, had significantly lower neurodevelopmental scores than the mild-exposed group in boys, but there was no difference in the ASRS scores. The present study demonstrates a specific impact of perinatal TCDD on autistic traits in childhood, which is different from the neurotoxicity of total dioxins (PCDDs/Fs).
authors.affiliation: Department of Public Health, Kanazawa Medical University, Ishikawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishijo
authors.affiliation: Biomedical and Pharmaceutical Research Center, Vietnam Military Medical University, Ha Noi, Vietnam.
authors.forename: T T
authors.initials: TT
authors.lastname: Pham
authors.affiliation: Department of Public Health, Kanazawa Medical University, Ishikawa, Japan.
authors.forename: A T N
authors.initials: AT
authors.lastname: Nguyen
authors.affiliation: Department of Public Health, Kanazawa Medical University, Ishikawa, Japan.
authors.forename: N N
authors.initials: NN
authors.lastname: Tran
authors.affiliation: Department of Public Health, Kanazawa Medical University, Ishikawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.affiliation: Biomedical and Pharmaceutical Research Center, Vietnam Military Medical University, Ha Noi, Vietnam.
authors.forename: L V
authors.initials: LV
authors.lastname: Hoang
authors.affiliation: Biomedical and Pharmaceutical Research Center, Vietnam Military Medical University, Ha Noi, Vietnam.
authors.forename: A H
authors.initials: AH
authors.lastname: Tran
authors.affiliation: School of Nursing, Kanazawa Medical University, Ishikawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Morikawa
authors.affiliation: Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan.
authors.forename: M D
authors.initials: MD
authors.lastname: Ho
authors.affiliation: Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kido
authors.affiliation: 1] Biomedical and Pharmaceutical Research Center, Vietnam Military Medical University, Ha Noi, Vietnam [2] System Emotional Science, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan.
authors.forename: M N
authors.initials: MN
authors.lastname: Nguyen
authors.affiliation: 1] Biomedical and Pharmaceutical Research Center, Vietnam Military Medical University, Ha Noi, Vietnam [2] System Emotional Science, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan.
authors.forename: H M
authors.initials: HM
authors.lastname: Nguyen
authors.affiliation: System Emotional Science, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nishijo
mesh_terms: D001321:Autistic Disorder / Q000453:epidemiology*; D001572:Benzofurans / Q000009:adverse effects / Q000032:analysis; D002657:Child Development / Q000187:drug effects; D002675:Child, Preschool; D015331:Cohort Studies; D004147:Dioxins / Q000009:adverse effects / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D018811:Maternal Exposure; D008895:Milk, Human / Q000737:chemistry*; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects* / Q000032:analysis*; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors; D014744:Vietnam / Q000453:epidemiology
chemical_list: D001572:Benzofurans; D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; C023614:dibenzofuran; C020887:dibenzo(1,4)dioxin