title: In vitro comparison of stannous fluoride, sodium fluoride, and sodium monofluorophosphate dentifrices in the prevention of enamel erosion.
abstract: OBJECTIVE
  To compare the relative performance of commercially available dentifrices containing different types of fluoride to reduce enamel erosion from citric acid.
  
  
  METHODS
  Two randomized parallel-group experiments were conducted, each with 48 bovine enamel samples randomly divided into six treatment legs. Each treatment leg went through 24 toothpaste treatment cycles, acid challenge (0.05M citric acid), and remineralization in artificial saliva. Total acid immersion after all cycles was 300 minutes for each test product; two test products in Experiment 1 were also evaluated for 180 minutes for comparison. Samples were analyzed blinded to treatment group for enamel loss by contact profilometry. One stabilized stannous fluoride (SnF2) dentifrice was compared to three sodium fluoride (NaF) dentifrices, two sodium monofluorophosphate (MFP) dentifrices, and one MFP plus calcium sodium phosphosilicate (CSP) dentifrice. All fluoride levels were 1450 ppm. A water control was also included.
  
  
  RESULTS
  The dentifrice containing stabilized SnF2 was significantly (p < 0.0001) better at preventing enamel erosion compared to the NaF and MFP dentifrices. The SnF, dentifrice provided a 61.7% (p < 0.0001) reduction in enamel loss versus the water control. The comparable figures for NaF and MFP dentifrices were 36-39% (p < 0.0001) and 33% (p < 0.0001) reductions, respectively, compared to the water control. The MFP+CSP dentifrice was significantly (p < 0.05) less effective, providing a 23.2% (p = 0.0007) reduction versus the water control.
  
  
  CONCLUSIONS
  Of the dentifrices included in this research, the stabilized SnF, dentifrice was the most effective at reducing enamel erosion from citric acid.
authors.forename: A M
authors.initials: AM
authors.lastname: Paepegaey
authors.forename: T N
authors.initials: TN
authors.lastname: Day
authors.forename: A
authors.initials: A
authors.lastname: Boulding
authors.forename: R
authors.initials: R
authors.lastname: Harris
authors.forename: M L
authors.initials: ML
authors.lastname: Barker
authors.forename: P G
authors.initials: PG
authors.lastname: Bellamy
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002417:Cattle; D019343:Citric Acid / Q000009:adverse effects; D003743:Dental Enamel / Q000187:drug effects; D003802:Dentifrices / Q000627:therapeutic use*; D005459:Fluorides / Q000627:therapeutic use*; D010710:Phosphates / Q000627:therapeutic use*; D012464:Saliva, Artificial; D012969:Sodium Fluoride / Q000627:therapeutic use*; D014002:Tin Fluorides / Q000627:therapeutic use*; D014077:Tooth Erosion / Q000517:prevention & control*
chemical_list: D003802:Dentifrices; D010710:Phosphates; D012464:Saliva, Artificial; D014002:Tin Fluorides; C012980:fluorophosphate; D019343:Citric Acid; D012969:Sodium Fluoride; D005459:Fluorides