title: NLRC3 puts the brakes on STING.
abstract: NOD-like receptors (NLRs) are increasingly implicated in regulating pathogen-sensing pathways. In this issue of Immunity, Zhang et al. (2014) describe a role for NLRC3 in regulating STING and the inflammatory response to cytosolic DNA.
authors.affiliation: Institute of Innate Immunity, University Hospitals, Biomedical Centre, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
authors.forename: Matthew S J
authors.initials: MS
authors.lastname: Mangan
authors.affiliation: Institute of Innate Immunity, University Hospitals, Biomedical Centre, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01615, USA. Electronic address: eicke.latz@umassmed.edu.
authors.forename: Eicke
authors.initials: E
authors.lastname: Latz
mesh_terms: D000818:Animals; D004247:DNA / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D015398:Signal Transduction; D000099197:STING Protein
chemical_list: D004247:DNA; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C588347:NLRC3 protein, mouse; C530855:Sting1 protein, mouse; D000099197:STING Protein