title: The concept behind sugammadex.
abstract: Sugammadex is the first selective relaxant binding agent. It allows rapid reversal of any degree of neuromuscular blockade induced by steroidal neuromuscular blocking agents. Sugammadex acts by encapsulation of the neuromuscular blocking agent. This prevents the drug from acting on prejunctional and postjunctional nicotinic receptors, allowing acetylcholine to activate these receptors, and resulting in reversal of the neuromuscular blockade. Objective monitoring of the degree of neuromuscular blockade is strongly recommended to determine the optimal dose of sugammadex. A good understanding of the concept behind sugammadex is essential in order to use this reversal agent in clinical practice.
authors.affiliation: Department of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom. Electronic address: r.epemolu@dundee.ac.uk.
authors.forename: O
authors.initials: O
authors.lastname: Epemolu
authors.affiliation: Department of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
authors.forename: A
authors.initials: A
authors.lastname: Bom
mesh_terms: D000109:Acetylcholine / Q000378:metabolism / Q000502:physiology; D000732:Androstanols / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000097:blood; D001667:Binding, Competitive; D055191:Delayed Emergence from Anesthesia / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000097:blood; D009994:Osmolar Concentration; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000502:physiology; D000077123:Rocuronium; D000077122:Sugammadex; D014673:Vecuronium Bromide / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000097:blood; D047408:gamma-Cyclodextrins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D011978:Receptors, Nicotinic; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D014673:Vecuronium Bromide; D000109:Acetylcholine; D000077123:Rocuronium
keywords: Farmacología; Fármacos bloqueantes neuromusculares; Neuromuscular blocking agents; Pharmacology; Reversal; Reversión; Rocuronio; Rocuronium; Sugammadex; Vecuronio; Vecuronium