title: Fluctuations in eGFR in relation to unenhanced and enhanced MRI and CT outpatients.
abstract: OBJECTIVE
  To study fluctuations in estimated glomerular filtration rate (eGFR) in relation to contrast medium (CM) enhanced magnetic resonance imaging (MRI) and computed tomography (CT) compared to control groups in outpatients.
  
  
  METHODS
  eGFR was determined right before the imaging procedure and three days later at the department or at the patient's home. The iodine-based and gadolinium-based contrast media were the same as used for all other examinations at the department.
  
  
  RESULTS
  A total of 716 patients completed the study. There was a statistically significant, but not clinically relevant rise in eGFR after three days in all four groups. The average eGFR variation was 4.8 ml/min/1.73 m(2). There were large variations in eGFR between the two measurements in 45.8% of the patients as they had a change greater than ± 10 ml/min/1.73 m(2). Only three patients fulfilled the contrast-induced nephropathy (CIN) requirement when the definition s-creatinine ≥ 44 μmol/l (0.5mg/dl) was used.
  
  
  CONCLUSIONS
  eGFR in outpatients undergoing MRI or CT did vary independently of whether the patient received contrast or not. The findings probably reflect the natural variations in s-creatinine levels. This should be taken into consideration when CIN is studied.
authors.affiliation: Department of Diagnostic Radiology, Copenhagen University Hospital Herlev, Herlev Ringvej 75, DK 2730 Herlev, Denmark. Electronic address: manalazzouz@gmail.com.
authors.forename: Manal
authors.initials: M
authors.lastname: Azzouz
authors.affiliation: Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
authors.forename: Janne
authors.initials: J
authors.lastname: Rømsing
authors.affiliation: Department of Diagnostic Radiology, Copenhagen University Hospital Herlev, Herlev Ringvej 75, DK 2730 Herlev, Denmark.
authors.forename: Henrik S
authors.initials: HS
authors.lastname: Thomsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care / Q000706:statistics & numerical data; D016477:Artifacts; D003287:Contrast Media; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D015994:Incidence; D007479:Iopamidol / Q000009:adverse effects / Q000031:analogs & derivatives*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology*; D008279:Magnetic Resonance Imaging / Q000009:adverse effects*; D008297:Male; D008536:Meglumine / Q000009:adverse effects*; D008875:Middle Aged; D009942:Organometallic Compounds / Q000009:adverse effects*; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C057937:iomeprol; D008536:Meglumine; D007479:Iopamidol; C072417:gadoterate meglumine
keywords: CIN; Fluctuations; Gadolinium-based contrast media; Iodine-based contrast media; Outpatients; eGFR