title: Lack of association between thePIN1promoter -667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta-analysis.
abstract: Peptidyl-prolylcis-trans isomerase NIMA-interacting 1 (PIN1) is a critical catalyst involved in multiple oncogenic signaling pathways. ThePIN1promoter -667T>C (rs2233679) polymorphism plays a role in cancer risk. The association betweenPIN1(-667T>C) polymorphism and cancer risk has been previously investigated. However, the available results are inconclusive. To derive a more precise estimation, a meta-analysis of seven published case-control studies including 4,524 cases with different tumor types and 4,561 controls was performed. Published literature from PubMed and EMBASE was retrieved. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Overall, the results did not suggest any associations between thePIN1promoter (-667T>C) polymorphism and cancer susceptibility (OR=1.04, 95% CI: 0.91-1.18 for CC vs. TT; OR=0.98, 95% CI: 0.89-1.09 for TC vs. TT; OR=1.00, 95% CI: 0.91-1.10 for TC/CC vs. TT; OR=1.07, 95% CI: 0.97-1.18 for CC vs. TC/TT). Further stratified analysis by cancer type, ethnicity and sample size did not reveal any significant associations in the genetic models. The results of the present study demonstrate that thePIN1promoter (-667T>C; rs2233679) polymorphism is not associated with cancer susceptibility.
authors.affiliation: Department of Urology and Institute of Prostatic Diseases, The Affiliated Wuhu No. 2 People's Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Liangjun
authors.initials: L
authors.lastname: Tao
authors.affiliation: Department of Urology and Institute of Prostatic Diseases, The Affiliated Wuhu No. 2 People's Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Yisheng
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Urology and Institute of Prostatic Diseases, The Affiliated Wuhu No. 2 People's Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Lingsong
authors.initials: L
authors.lastname: Tao
authors.affiliation: Department of Urology and Institute of Prostatic Diseases, The Affiliated Wuhu No. 2 People's Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Kong
authors.affiliation: Department of Urology and Institute of Prostatic Diseases, The Affiliated Wuhu No. 2 People's Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Qin
authors.affiliation: Department of Urology and Institute of Prostatic Diseases, The Affiliated Wuhu No. 2 People's Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Urology and Institute of Prostatic Diseases, The Affiliated Wuhu No. 2 People's Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zou
authors.affiliation: Department of Psychiatry, The Affiliated Wuhu No. 2 People's Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
authors.forename: Sizhong
authors.initials: S
authors.lastname: He
keywords: cancer; meta-analysis; peptidyl-prolylcis-trans isomerase NIMA-interacting 1; polymorphism