title: A new compound from an endophytic fungus Alternaria tenuissima.
abstract: A new secondary metabolite, named altertoxin IV (1), together with altertoxin II (2), was isolated from the fermentation broth of Alternaria tenuissima, an endophytic fungal strain residing in the stem of Tribulus terrestris L. The structure of new compound 1 was established by HR-ESI-MS, multinuclear NMR spectroscopy, and single crystal X-ray diffraction method. In their in vitro bioassay, compound 2 exhibited moderate cytotoxic activity against PC-3 cell lines with an IC50 value of 14.28 μM.
authors.affiliation: a School of Life Science, East China Normal University , Shanghai 200241 , China.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Wu
authors.forename: Gao-Chao
authors.initials: GC
authors.lastname: Yue
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Huang
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Sun
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D000528:Alternaria / Q000737:chemistry*; D001551:Benz(a)Anthracenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009183:Mycotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000382:microbiology; D032444:Tribulus / Q000382:microbiology; D014961:X-Ray Diffraction
chemical_list: D001551:Benz(a)Anthracenes; D009183:Mycotoxins; C000592305:altertoxin IV
keywords: Alternaria tenuissima; altertoxin IV; cytotoxicity; endophytic fungus