title: Obsessive-compulsive disorder: a "sensory-motor" problem?
abstract: Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition. Although its pathophysiology is not completely understood, neurophysiologic and neuroimaging data have disclosed functional abnormalities in the networks linking frontal cortex, supplementary motor and premotor areas, striatum, globus pallidus, and thalamus (CSPT circuits). By means of transcranial magnetic stimulation (TMS) it is possible to test inhibitory and excitatory circuits within motor cortex. Previous studies on OCD patients under medication have demonstrated altered cortical inhibitory circuits as tested by TMS. On the other hand there is growing evidence suggesting an alteration of sensory-motor integration. Therefore, the aim of the present study was to evaluate sensory-motor integration (SAI and LAI), intracortical inhibition, and facilitation in drug-naïve OCD patients, using TMS. In our sample, we have demonstrated a significant SAI reduction in OCD patients when compared to a cohort of healthy individuals. SAI abnormalities may be related to a dysfunction of CSPT circuits which are involved in sensory-motor integration processes. Thus, it can be speculated that hypofunctioning of such system might impair the ability of OCD patients to suppress internally triggered intrusive and repetitive movements and thoughts. In conclusion, our data suggest that OCD may be considered as a sensory motor disorder where a dysfunction of sensory-motor integration may play an important role in the release of motor compulsions.
authors.affiliation: IRCCS Centro Neurolesi Bonino-Pulejo Messina, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Russo
authors.affiliation: IRCCS Centro Neurolesi Bonino-Pulejo Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Naro
authors.affiliation: Department of Neuroscience, University of Messina, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Mastroeni
authors.affiliation: Department of Neuroscience, University of Messina, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Morgante
authors.affiliation: Department of Neuroscience, University of Messina, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Terranova
authors.affiliation: Department of Neuroscience, University of Messina, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Muscatello
authors.affiliation: Department of Neuroscience, University of Messina, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Zoccali
authors.affiliation: IRCCS Centro Neurolesi Bonino-Pulejo Messina, Italy. Electronic address: salbro77@tiscali.it.
authors.forename: R S
authors.initials: RS
authors.lastname: Calabrò
authors.affiliation: Department of Neuroscience, University of Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Quartarone
mesh_terms: D000328:Adult; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology; D009433:Neural Inhibition / Q000502:physiology*; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D011897:Random Allocation; D066191:Sensorimotor Cortex / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation / Q000295:instrumentation / Q000379:methods*
keywords: Obsessive compulsive disorders; Sensory-gating control; Transcranial magnetic stimulation