title: Use of the modified Atkins diet in Lennox Gastaut syndrome.
abstract: There is scanty data regarding the efficacy and tolerability of the modified Atkins diet in children with Lennox-Gastaut syndrome. This study was a retrospective review of children with Lennox-Gastaut syndrome treated with the modified Atkins diet from May 2009 and March 2011. The diet was initiated in those children who persisted to have daily seizures despite the use of at least 3 appropriate antiepileptic drugs. Twenty-five children were started on a modified Atkins diet, restricting carbohydrate intake to 10 g/d. After 3 months, 2 patients were seizure-free, and 10/25 children had >50% reduction in seizure frequency. At 6 months, of 11 patients on the diet, 3 were seizure free and 8 had >50% reduction in seizure frequency. At 1 year, all 9 children on diet had >50% reduction in seizure frequency. The side effects of the diet were mild. The modified Atkins diet was found to be effective and well tolerated in children with Lennox-Gastaut syndrome.
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India Division of Pediatric Neurology, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India.
authors.forename: Suvasini
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India Division of Pediatric Neurology, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India.
authors.forename: Puneet
authors.initials: P
authors.lastname: Jain
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India sheffaligulati@gmail.com.
authors.forename: Sheffali
authors.initials: S
authors.lastname: Gulati
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Naveen
authors.initials: N
authors.lastname: Sankhyan
authors.affiliation: Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Anuja
authors.initials: A
authors.lastname: Agarwala
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D050528:Diet, Carbohydrate-Restricted / Q000009:adverse effects / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007659:Ketones / Q000652:urine; D065768:Lennox Gastaut Syndrome / Q000178:diet therapy* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D012189:Retrospective Studies; D012640:Seizures / Q000178:diet therapy / Q000188:drug therapy / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D007659:Ketones
keywords: Lennox-Gastaut syndrome; ketogenic diet; ketosis; modified Atkins diet; nonpharmacologic therapy; refractory epilepsy