title: The effect of blood glucose and pCO2 on spectral EEG of premature infants during the first three days of life.
abstract: BACKGROUND
  Spectral EEG analysis using automated quantification of total absolute band power (tABP) expresses brain function. We hypothesized that pCO2 or blood glucose affects tABP during the critical first days of life in premature infants.
  
  
  OBJECTIVE
  To use automated tABP quantification to determine whether EEG background activity in premature infants during the first 3 days of life is influenced by pCO2 or blood glucose levels.
  
  
  METHODS
  Preterm infants, group 1 [gestational age (GA) = 24-27 weeks] and group 2 (GA = 28-30 weeks), underwent continuous EEG monitoring for 3 days after birth. Biochemical data were extracted from the observational datasheet used during monitoring. Blood samples were taken at the request of the attending physician. Statistical analyses were performed as repeated measurements using linear mixed models with a random intercept. The effect of time was treated as a fixed covariate and the GA groups as a fixed factor in all models. Continuous data were described using the mean ± SD or median and range, and categorical data were described using the number of patients and percentages unless otherwise indicated.
  
  
  RESULTS
  There was an association between increased pCO2 and tABP and between increased blood glucose and tABP. Further, there were no differences in the responses between groups 1 and 2.
  
  
  CONCLUSIONS
  Both hyperglycemia and hypercapnia showed a negative effect on brain activity decreasing tABP during the first 3 days of life in premature infants.
authors.affiliation: Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: E M
authors.initials: EM
authors.lastname: Schumacher
authors.forename: P G
authors.initials: PG
authors.lastname: Larsson
authors.forename: A H
authors.initials: AH
authors.lastname: Pripp
authors.forename: T A
authors.initials: TA
authors.lastname: Stiris
mesh_terms: D001331:Automation; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000503:physiopathology*; D058256:Brain Waves; D002245:Carbon Dioxide / Q000097:blood*; D056805:Consciousness Monitors; D004569:Electroencephalography / Q000295:instrumentation; D005865:Gestational Age; D006801:Humans; D006935:Hypercapnia / Q000097:blood* / Q000503:physiopathology; D006943:Hyperglycemia / Q000097:blood* / Q000503:physiopathology; D062071:Infant, Extremely Premature / Q000097:blood; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D016014:Linear Models; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002245:Carbon Dioxide