title: [When senescence hits the immune system].
abstract: Ageing is associated with a reshaping of the immune system characterised by decreased adaptive immunity and systemic low-grade inflammation. These changes are associated with mortality in elderly cohorts and not only important in the defence to infectious diseases but also associated with almost all age-associated chronic diseases such as atherosclerosis, type 2 diabetes and dementia as well as their related risk factors. This review discusses underlying molecular and cellular mechanisms and possible intervention strategy today and in the future.
authors.affiliation: Klinisk Immunologisk Afdeling 7631, Rigshospitalet, Blegdamsvej 9, 2100 København Ø. helle.bruunsgaard@rh.regionh.dk
authors.forename: Helle
authors.initials: H
authors.lastname: Bruunsgaard
mesh_terms: D000375:Aging / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism