title: Advances in imaging-genetic relationships for Alzheimer's disease: clinical implications.
abstract: Alzheimer's disease (AD) is the most common cause of dementia and represents a major public health problem. From a clinical perspective, AD is devastating to patients and their families. The genetic approach to the study of dementia undoubtedly continues to provide a significant contribution to understanding the pathogenesis, diagnosis and therapeutic perspectives, but also raises important ethical implications. With advances in new technology, including genetics and PET/MRI scanning, the role of genetic studies and neuroimaging is being redefined as an aid in the clinical diagnosis of AD, and also in presymptomatic evaluation. Here, we review some of the issues related to the neuroimaging-genetic relationship in AD with a possible clinical implication as a preclinical biomarker for dementia and also for tracking disease progression.
authors.affiliation: Department of Neuroscience, Psychology, Drug Research & Child Health, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bagnoli
authors.forename: Irene
authors.initials: I
authors.lastname: Piaceri
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
authors.forename: Benedetta
authors.initials: B
authors.lastname: Nacmias
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D015415:Biomarkers; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D015415:Biomarkers