title: Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications.
abstract: Significant comorbidities between obesity-related metabolic disease and stress-related psychological disorders suggest important functional interactions between energy balance and brain stress integration. Largely overlapping neural circuits control these systems, and this anatomical arrangement optimizes opportunities for mutual influence. Here we first review the current literature identifying effects of metabolic neuroendocrine signals on stress regulation, and vice versa. Next, the contributions of reward-driven food intake to these metabolic and stress interactions are discussed. Lastly, we consider the interrelationships between metabolism, stress, and reward in light of their important implications in the development of therapies for metabolism- or stress-related disease.
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA.
authors.forename: Yvonne M
authors.initials: YM
authors.lastname: Ulrich-Lai
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA. Electronic address: karen.ryan@uc.edu.
authors.forename: Karen K
authors.initials: KK
authors.lastname: Ryan
mesh_terms: D050154:Adiposity / Q000502:physiology; D001921:Brain / Q000502:physiology*; D004435:Eating / Q000523:psychology; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000503:physiopathology* / Q000523:psychology; D009490:Neurosecretory Systems / Q000502:physiology*; D009765:Obesity / Q000503:physiopathology / Q000523:psychology; D012201:Reward; D015398:Signal Transduction / Q000502:physiology; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology