title: Lymphangiosarcoma of the scalp.
abstract: BACKGROUND
  Lymphangiosarcoma is a rare, aggressive malignancy that originates from the endothelial cells lining lymphatic vessels and carries an extremely poor prognosis. Its clinical and histologic features are often indistinguishable from angiosarcoma.
  
  
  OBJECTIVE
  We sought to better characterize the clinical and histologic features of lymphangiosarcoma.
  
  
  METHODS
  Case report and review of the literature.
  
  
  RESULTS
  A number of immunohistochemical markers, including Von Willebrand factor, Ulex europaeus agglutinin 1, CD31, VEGFR-3, D2-40, Prox-1, can be used to help differentiate lymphatic from vascular tissue.
  
  
  CONCLUSIONS
  Recent characterization of several new biologic markers has allowed greater differentiation between these tumors and may provide new therapeutic targets for treatment.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Mamelak
authors.forename: Megan R V
authors.initials: MR
authors.lastname: Collie
authors.forename: Ryan
authors.initials: R
authors.lastname: Kroll
authors.forename: Miriam L
authors.initials: ML
authors.lastname: Hanson
authors.forename: Howard M
authors.initials: HM
authors.lastname: Harris
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008204:Lymphangiosarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D012535:Scalp / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D014057:Tomography, X-Ray Computed