title: A clinical database of breast cancer patients reveals distinctive clinico-pathological characteristics: a study from central China.
abstract: BACKGROUND
  Breast cancer is the most common malignant tumor in females worldwide. Many differences exist in clinico-pathological characteristics of breast cancer patients between China and Western countries. This study aimed to analyze clinico-pathological characteristics of breast cancer from central China.
  
  
  METHODS
  Clinico- pathological information on breast cancer from three hospitals in central China was collected and analyzed.
  
  
  RESULTS
  From 1994 to 2012, 2,525 patients with a median age 50 years were included in this study. The 45-49-year age group and invasive ductal carcinoma not otherwise specified accounted for the highest proportions (19.1%, 480/2,525 and 81.0%, 1,982/2,446). Stages 0-I, II and III accounted for 28.0% (682/2,441), 48.4% (1,180/2,441), and 23.7% (578/2,441), respectively. Distribution of N stage showed that N0 accounted for 53.2% (1,344/2,525), and proportion of N0 rose from 51.1% (157/307) in 30-39-year age group to 64.3% (110/171) in ≥ 70-year age group, with an average increase of 2.1% in each age group. Modified radical mastectomy, radical mastectomy, breast-conserving surgery and simple mastectomy were performed for 71.8% (1,812/2,525), 18.0% (454/2,525), 5.2% (131/2,525) and 2.6% (66/2,525), respectively. Proportions of breast-conserving surgery in age ≤ 44-year group (68/132, 51.5%) and simple mastectomy in age ≥ 60-year group (57/89, 64.0%) were higher than in the other age groups. Breast cancers positive for estrogen receptor accounted for 53.0% (1,107/ 2,112). The comparisons among this study and other reports showed higher proportion of younger patients, lower proportion of breast- conserving surgery and positive estrogen receptor patients in China than western countries.
  
  
  CONCLUSIONS
  Clinico-pathological characteristics in this study demonstrated clear differences between the center of China than Western countries. Additional classification systems should be developed to guide grading of early breast cancer more accurately, especially for N0 patients. Invasive ductal carcinoma is a focus for intensive research.
authors.affiliation: Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, China E-mail : liyansd2@163.com.
authors.forename: Lin-Wei
authors.initials: LW
authors.lastname: Wang
authors.forename: Gui-Fang
authors.initials: GF
authors.lastname: Yang
authors.forename: Jia-Mei
authors.initials: JM
authors.lastname: Chen
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.forename: Jing-Ping
authors.initials: JP
authors.lastname: Yuan
authors.forename: Sheng-Rong
authors.initials: SR
authors.lastname: Sun
authors.forename: Chuang
authors.initials: C
authors.lastname: Chen
authors.forename: Ming-Bai
authors.initials: MB
authors.lastname: Hu
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D002681:China / Q000453:epidemiology; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015409:Mastectomy, Radical; D015412:Mastectomy, Segmental; D015413:Mastectomy, Simple; D008875:Middle Aged; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000378:metabolism; D044465:White People; D055815:Young Adult
chemical_list: D011960:Receptors, Estrogen