title: MeCP2 caught moonlighting as a suppressor of MicroRNA processing.
abstract: MeCP2 is a transcriptional regulator important for neurodevelopment and is involved in Rett syndrome and autism. In this issue of Developmental Cell, Cheng and colleagues (2014) report that MeCP2 also regulates microRNA biogenesis. MeCP2 phosphorylation induces a direct interaction with DGCR8, leading to reduced microRNA processing and retardation of dendritic growth.
authors.affiliation: Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, Korea.
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Woo
authors.affiliation: Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, Korea. Electronic address: narrykim@snu.ac.kr.
authors.forename: V Narry
authors.initials: VN
authors.lastname: Kim
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D049229:Dendritic Spines / Q000502:physiology*; D051783:Methyl-CpG-Binding Protein 2 / Q000378:metabolism* / Q000502:physiology*; D035683:MicroRNAs / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D043244:Ribonuclease III / Q000378:metabolism*
chemical_list: C474044:Dgcr8 protein, mouse; C497393:Mecp2 protein, mouse; C497394:Mecp2 protein, rat; D051783:Methyl-CpG-Binding Protein 2; D035683:MicroRNAs; D016601:RNA-Binding Proteins; C513400:Drosha protein, mouse; D043244:Ribonuclease III