title: Innate immunity in disease.
abstract: Cells can innately recognize generic products of viruses, bacteria, fungi, or injured tissue by engagement of pattern recognition receptors. Innate immune cells rapidly respond to this engagement to control commensals, thwart pathogens, and/or prompt repair. Insufficient or excessive activation of the innate immune response results in disease. This review focuses on pattern recognition receptors and cells of the innate immune system that are important for intestinal function. Our improving knowledge pertaining to this important aspect of our immune response is opening potential important new therapeutic opportunities for the treatment of disease.
authors.affiliation: Division of Gastroenterology/Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa.
authors.forename: David E
authors.initials: DE
authors.lastname: Elliott
authors.affiliation: Division of Gastroenterology-Hepatology, Department of Internal Medicine, Tufts Medical Center, Boston, Massachusetts.
authors.forename: Sana S
authors.initials: SS
authors.lastname: Siddique
authors.affiliation: Division of Gastroenterology-Hepatology, Department of Internal Medicine, Tufts Medical Center, Boston, Massachusetts. Electronic address: jweinstock2@tuftsmedicalcenter.org.
authors.forename: Joel V
authors.initials: JV
authors.lastname: Weinstock
mesh_terms: D016207:Cytokines / Q000378:metabolism; D005767:Gastrointestinal Diseases / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007113:Immunity, Innate; D007962:Leukocytes / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000378:metabolism
chemical_list: D016207:Cytokines; D051192:Receptors, Pattern Recognition
keywords: Colitis; Gastroenterology; Innate Immunity; Mucosa