title: Intratendinous injection of platelet-rich plasma under US guidance to treat tendinopathy: a long-term pilot study.
abstract: OBJECTIVE
  To assess the potential therapeutic effect of intratendinous injection of platelet-rich plasma (PRP) under ultrasound (US) guidance to treat tendon tears and tendinosis in a pilot study with long-term follow-up.
  
  
  METHODS
  The study included 408 consecutive patients referred for treatment by PRP injection of tendinopathy in the upper (medial and lateral epicondylar tendons) and the lower (patellar, Achilles, hamstring and adductor longus, and peroneal tendons) limb who received a single intratendinous injection of PRP under US guidance. Clinical and US data were retrospectively collected for each anatomic compartment for upper and lower limbs before treatment (baseline) and 6 weeks after treatment. Late clinical data without US were collected until 32 months after the procedure (mean, 20.2 months). The McNemar test and regression model were used to compare clinical and US data.
  
  
  RESULTS
  QuickDASH score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and residual US size of lesions were significantly lower after intratendinous injection of PRP under US guidance at 6 weeks and during long-term follow-up compared with baseline (P < .001 in upper and lower limb) independent of age, gender, and type of tendinopathy (P > .29). No clinical complication was reported during follow-up.
  
  
  CONCLUSIONS
  Intratendinous injection of PRP under US guidance appears to allow rapid tendon healing and is well tolerated.
authors.affiliation: Service de Radiologie, Hôpital Universitaire Bichat, 46, rue Henri Huchard, 75018 Paris; Inserm U698, Hôpital Universitaire Bichat, 46, rue Henri Huchard, 75018 Paris; Université Paris Diderot, Paris. Electronic address: benjamin.dallaudiere@gmail.com.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Dallaudière
authors.affiliation: Centre d'Imagerie Ostéo Articulaire, Clinique du Sport de Bordeaux-Mérignac, Mérignac.
authors.forename: Lionel
authors.initials: L
authors.lastname: Pesquer
authors.affiliation: Centre d'Imagerie Ostéo Articulaire, Clinique du Sport de Bordeaux-Mérignac, Mérignac.
authors.forename: Philippe
authors.initials: P
authors.lastname: Meyer
authors.affiliation: Centre d'Imagerie Ostéo Articulaire, Clinique du Sport de Bordeaux-Mérignac, Mérignac.
authors.forename: Alain
authors.initials: A
authors.lastname: Silvestre
authors.affiliation: Unité de Recherche Clinique, Paris Nord, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Perozziello
authors.affiliation: Centre d'Imagerie Ostéo Articulaire, Clinique du Sport de Bordeaux-Mérignac, Mérignac.
authors.forename: Alain
authors.initials: A
authors.lastname: Peuchant
authors.affiliation: Centre d'Imagerie Ostéo Articulaire, Clinique du Sport de Bordeaux-Mérignac, Mérignac.
authors.forename: Marie Hélène Moreau
authors.initials: MH
authors.lastname: Durieux
authors.affiliation: Service d'Orthopédie, Hôpital Universitaire Bichat, 46, rue Henri Huchard, 75018 Paris.
authors.forename: Philippe
authors.initials: P
authors.lastname: Loriaut
authors.affiliation: Service de Radiologie, Hôpital Universitaire Bichat, 46, rue Henri Huchard, 75018 Paris.
authors.forename: Vincent
authors.initials: V
authors.lastname: Hummel
authors.affiliation: Service d'Orthopédie, Hôpital Universitaire Bichat, 46, rue Henri Huchard, 75018 Paris.
authors.forename: Patrick
authors.initials: P
authors.lastname: Boyer
authors.affiliation: Service de Radiologie, Hôpital Universitaire Bichat, 46, rue Henri Huchard, 75018 Paris; Université Paris Diderot, Paris.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Schouman-Claeys
authors.affiliation: Service de Radiologie, Hôpital Universitaire Bichat, 46, rue Henri Huchard, 75018 Paris; Inserm U698, Hôpital Universitaire Bichat, 46, rue Henri Huchard, 75018 Paris; Université Paris Diderot, Paris.
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Serfaty
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015552:Injections, Intralesional / Q000379:methods; D008297:Male; D017713:Platelet Transfusion / Q000379:methods*; D053657:Platelet-Rich Plasma / Q000000981:diagnostic imaging*; D052256:Tendinopathy / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*