title: A highly sensitive electrochemical genosensor based on Co-porphyrin-labelled DNA.
abstract: We report the use of Co-porphyrins as electrochemical tags for a highly sensitive and selective genosensor. An avian influenza virus-based DNA sequence characteristic of H5N1 was detected at femtomolar levels from competing non-complementary sequences through hybridisation with the labeled DNA.
authors.affiliation: Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland. j.radecki@pan.olsztyn.pl.
authors.forename: Iwona
authors.initials: I
authors.lastname: Grabowska
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Singleton
authors.forename: Anna
authors.initials: A
authors.lastname: Stachyra
authors.forename: Anna
authors.initials: A
authors.lastname: Góra-Sochacka
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Sirko
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Zagórski-Ostoja
authors.forename: Hanna
authors.initials: H
authors.lastname: Radecka
authors.forename: Eugen
authors.initials: E
authors.lastname: Stulz
authors.forename: Jerzy
authors.initials: J
authors.lastname: Radecki
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D015342:DNA Probes / Q000737:chemistry* / Q000235:genetics; D004279:DNA, Viral / Q000032:analysis* / Q000235:genetics; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods; D004566:Electrodes; D006046:Gold / Q000737:chemistry; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D011166:Porphyrins / Q000737:chemistry*
chemical_list: D015342:DNA Probes; D004279:DNA, Viral; D011166:Porphyrins; D006046:Gold