title: Modular approach to substituted Boc-protected 4-(aminomethyl)pyrroles.
abstract: The radical addition of various α-xanthyl ketones to Boc-protected azetine gives adducts which, when treated with ammonia or primary amines, furnish 2,4-disubstituted, 2,3,4-trisubstituted, and polycyclic pyrroles having a protected aminomethyl group at position 4. An unusual ring-opening was observed in the case of a cyclobutanone precursor.
authors.affiliation: Laboratoire de Synthèse Organique, UMR 7652 CNRS/ Ecole Polytechnique , 91128 Palaiseau Cedex, France.
authors.forename: Songzhe
authors.initials: S
authors.lastname: Han
authors.forename: Samir Z
authors.initials: SZ
authors.lastname: Zard
mesh_terms: D000588:Amines / Q000737:chemistry; D001385:Azetines / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D001385:Azetines; D006576:Heterocyclic Compounds, 4 or More Rings; D007659:Ketones; D011758:Pyrroles