title: 3,4-seco-24-homo-28-nor-Cycloartane and drimane-type sesquiterpenes and their lactams from the EtOAc-soluble fraction of a leaf extract of Cinnamosma fragrans and their biological activity.
abstract: From the EtOAc-soluble fraction of a MeOH extract of leaves of Cinnamosma fragrans, seven new compounds, including 3,4-seco-24-homo-28-nor-cycloartane, drimane-type sesquiterpenes and their lactams, and two known compounds were isolated. Their structures were elucidated by extensive analyses of spectroscopic data. The cytotoxicity, anti-multidrug resistance activity, and anti-Leishmania activity of a cycloartane derivative and drimane-type sesquiterpene derivatives were assayed. The cycloartane derivative showed strong cytotoxicity, and some drimanes and drimane lactam showed moderate anti-multidrug resistance and anti-Leishmania activity.
authors.affiliation: Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Nomoto
authors.forename: Liva
authors.initials: L
authors.lastname: Harinantenaina
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sugimoto
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Matsunami
authors.forename: Hideaki
authors.initials: H
authors.lastname: Otsuka
mesh_terms: D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry; D018432:Drug Resistance, Multiple / Q000187:drug effects; D006801:Humans; D007769:Lactams / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D018320:Leishmania major / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity
chemical_list: C000590805:3,4-seco-24-homo-28-nor-cycloartane; D003603:Cytotoxins; D007769:Lactams; D010936:Plant Extracts; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D014315:Triterpenes; C437376:drimane