title: Reprint of: A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: design of the NU-AGE dietary intervention study.
abstract: BACKGROUND
  The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper describes the design of a healthful diet intervention on inflammageing and its consequences in the elderly.
  
  
  METHODS
  The NU-AGE study is a parallel randomized one-year trial in 1250 apparently healthy, independently living European participants aged 65-80 years. Participants are randomised into either the diet group or control group. Participants in the diet group received dietary advice aimed at meeting the nutritional requirements of the ageing population. Special attention was paid to nutrients that may be inadequate or limiting in diets of elderly, such as vitamin D, vitamin B12, and calcium. C-reactive protein is measured as primary outcome.
  
  
  CONCLUSIONS
  The NU-AGE study is the first dietary intervention investigating the effect of a healthful diet providing targeted nutritional recommendations for optimal health and quality of life in apparently healthy European elderly. Results of this intervention will provide evidence on the effect of a healthful diet on the prevention of age related decline.
authors.affiliation: Wageningen University, Department of Human Nutrition, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. Electronic address: Agnes.Berendsen@wur.nl.
authors.forename: Agnes
authors.initials: A
authors.lastname: Berendsen
authors.affiliation: University of Bologna, Department of Experimental Diagnostic and Specialty Medicine, Via San Giacomo, 12, 40126 Bologna, Italy. Electronic address: Aurelia.santoro@unibo.it.
authors.forename: Aurelia
authors.initials: A
authors.lastname: Santoro
authors.affiliation: C.I.G. Interdeparmental Centre 'L. Galvani', University of Bologna, Via San Giacomo, 12, 40126 Bologna, Italy. Electronic address: Elisa.Pini5@unibo.it.
authors.forename: Elisa
authors.initials: E
authors.lastname: Pini
authors.affiliation: University of Bologna, Department of Experimental Diagnostic and Specialty Medicine, Via San Giacomo, 12, 40126 Bologna, Italy. Electronic address: Elisa.Cevenini3@unibo.it.
authors.forename: Elisa
authors.initials: E
authors.lastname: Cevenini
authors.affiliation: University of Bologna, Department of Experimental Diagnostic and Specialty Medicine, Via San Giacomo, 12, 40126 Bologna, Italy. Electronic address: Rita.Ostan3@unibo.it.
authors.forename: Rita
authors.initials: R
authors.lastname: Ostan
authors.affiliation: Warsaw University of Life Sciences-SGGW, Faculty of Human Nutrition and Consumer Sciences, Nowoursynowska 159c str, 02-776 Warsaw, Poland. Electronic address: Barbara_Pietruszka@sggw.pl.
authors.forename: Barbara
authors.initials: B
authors.lastname: Pietruszka
authors.affiliation: Warsaw University of Life Sciences-SGGW, Faculty of Human Nutrition and Consumer Sciences, Nowoursynowska 159c str, 02-776 Warsaw, Poland. Electronic address: Katarzyna_Rolf@sggw.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Rolf
authors.affiliation: CHU Clermont-Ferrand, Service de Nutrition, F-63003 Clermont-Ferrand; INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France. Electronic address: noel.cano@clermont.inra.fr.
authors.forename: Noël
authors.initials: N
authors.lastname: Cano
authors.affiliation: CHU Clermont-Ferrand, Service de Nutrition, F-63003 Clermont-Ferrand; INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France. Electronic address: aurelie.caille@clermont.inra.fr.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Caille
authors.affiliation: CHU Clermont-Ferrand, Service de Nutrition, F-63003 Clermont-Ferrand; INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France. Electronic address: nlyonbelgy@chu-clermontferrand.fr.
authors.forename: Noëlle
authors.initials: N
authors.lastname: Lyon-Belgy
authors.affiliation: Norwich Medical School, Department of Nutrition, University of East Anglia, Norwich NR4 7TJ, UK. Electronic address: S.Fairweather-Tait@uea.ac.uk.
authors.forename: Susan
authors.initials: S
authors.lastname: Fairweather-Tait
authors.affiliation: Wageningen University, Department of Human Nutrition, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. Electronic address: Edith.Feskens@wur.nl.
authors.forename: Edith
authors.initials: E
authors.lastname: Feskens
authors.affiliation: C.I.G. Interdeparmental Centre 'L. Galvani', University of Bologna, Via San Giacomo, 12, 40126 Bologna, Italy. Electronic address: Claudio.Franceschi@unibo.it.
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
authors.affiliation: Wageningen University, Department of Human Nutrition, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. Electronic address: Lisette.deGroot@wur.nl.
authors.forename: C P G M
authors.initials: CP
authors.lastname: de Groot
keywords: Ageing; Elderly; Intervention; Nutrition