title: Synthesis and antimetastatic effects of E-salignone amide derivatives.
abstract: The preparation of novel E-salignone derivatives and their biological evaluation as potential antimetastatic agents is described. The E-salignone amide derivatives were prepared from epiandrosterone and androsterone, and characterized by analytical (1) H NMR, (13) C NMR, and mass spectrometry. The derivatives were evaluated for antimetastatic activity in MDA-MB-231 cells by using a transwell assay. Comparing with the positive control, LY294002, compounds 19b, 19d, and 19e exhibited significant inhibitory effects on the EGF-induced invasion of MB-MDA-231 cells. Moreover, compound 19b also had antimigration effects in wound-healing assay. Compound 19b may represent a novel antimetastatic agent for treating breast cancer.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China.
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Wang
authors.forename: Nan
authors.initials: N
authors.lastname: Qin
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Mei-Na
authors.initials: MN
authors.lastname: Jin
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Jin
authors.forename: Dexin
authors.initials: D
authors.lastname: Kong
authors.forename: Shen-De
authors.initials: SD
authors.lastname: Jiang
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Duan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology / Q000517:prevention & control*; D002465:Cell Movement / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology; D005260:Female; D006801:Humans; D015394:Molecular Structure; D009025:Morpholines / Q000494:pharmacology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D031236:Pachysandra / Q000737:chemistry; D011283:Pregnenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002867:Chromones; D009025:Morpholines; D011283:Pregnenes; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
keywords: E-salignone; amide derivatives; antimetastasis; breast cancer cells