title: Synthesis and pharmacological screening of some novel anti-hypertensive agents possessing 5-Benzylidene-2-(phenylimino)-thiazolidin-4-one ring.
abstract: In the present study, fourteen derivatives comprising of 5-benzylidene-2-(phenylimino)-thiazolidin-4-one moiety were synthesized. The structures of synthesized compounds were established by elemental analysis, IR, (1)H NMR, (13)C NMR and mass spectral data and tested for electrocardiographic, antiarrhythmic and antihypertensive activities. Compound 11 was found to be most potent in this series. The pharmacological results suggested that, the antiarrhythmic effects of these compounds were related to their Ca(++) ion channel antagonistic properties, which are believed to be due to the presence of 5-benzilidine-2-(phenylimino)-thiazolidin-4-one moiety. The antihypertensive effect of β-blocker side chain is enhanced by the presence of less bulky aliphatic and heterocyclic tertiary amines.
authors.affiliation: Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara 571448, Nagamangala (tq), Mandya (dist), Karnataka, India. Electronic address: chetanbhalgat2004@gmail.com.
authors.forename: Chetan M
authors.initials: CM
authors.lastname: Bhalgat
authors.affiliation: Department of Pharmaceutical Chemistry, SCSSS'S Sitabai Thite College of Pharmacy, Shirur, 412210 Pune, Maharashtra, India. Electronic address: darda.pooja@gmail.com.
authors.forename: Pooja V
authors.initials: PV
authors.lastname: Darda
authors.affiliation: Department of Pharmaceutical Chemistry, (PG Wing), A.I.S.S.M.S. College of Pharmacy, Pune 411 001, Maharashtra, India.
authors.forename: Kailash G
authors.initials: KG
authors.lastname: Bothara
authors.affiliation: Department of Pharmaceutical Chemistry, (PG Wing), A.I.S.S.M.S. College of Pharmacy, Pune 411 001, Maharashtra, India.
authors.forename: Shashikant V
authors.initials: SV
authors.lastname: Bhandari
authors.affiliation: Department of Pharmacognosy, Ashokrao Mane College of Pharmacy, Peth Vadgaon 416 112, Maharashtra, India.
authors.forename: Jotsna
authors.initials: J
authors.lastname: Gandhi
authors.affiliation: Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara 571448, Nagamangala (tq), Mandya (dist), Karnataka, India.
authors.forename: B
authors.initials: B
authors.lastname: Ramesh
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051381:Rats; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000959:Antihypertensive Agents; D053778:Thiazolidines
keywords: Antiarrhythmic; Antihypertensive; Hybrid; Propanolamine; Thiazolidinone