title: Polymorphisms ofDRD2andDRD3genes and Parkinson's disease: A meta-analysis.
abstract: Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects ~2% of the population aged ≥65 years. The degeneration of dopamine neurons in the substantia nigra contributes to the pathogenesis of PD.Dopamine receptor D2(DRD2)anddopamine receptor D3(DRD3)are two key subtypes of dopamine receptors. The aim of our study was to evaluate the association between the polymorphisms ofDRD2andDRD3genes and PD. Meta-analyses were conducted from 16 studies (46 stages) among 4,279 cases and 5,661 controls between PD and 9 polymorphisms (DRD2: rs1800497, rs1079597, rs6278, rs6279, rs273482, rs1799732 and rs1076563;DRD3: rs6280 and rs2134655). A significant association was observed betweenDRD3rs2134655 polymorphism and PD [P=0.01, odds ratio (OR)=1.17, 95% confidence interval (CI): 1.03-1.32] and a borderline association was observed betweenDRD2rs1800497 polymorphism and PD in Europeans (P=0.05, OR=1.13, 95% CI: 1.00-1.27). Findings of the current meta-analysis suggested thatDRD3rs2134655 polymorphism was associated with a 17% increased risk of PD and thatDRD2rs1800497 polymorphism had a potential to increase the risk of PD by 13% in Europeans. Future large-scale studies are required to confirm the ethnic difference ofDRD2rs1800497 polymorphism and to determine whether there were significant associations of PD with other polymorphisms inDRD2andDRD3genes.
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China ; Department of Neurology, Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Dongjun
authors.initials: D
authors.lastname: Dai
authors.affiliation: Department of Neurology, 148 Central Hospital of PLA, Zibo, Shandong 255300, P.R. China.
authors.forename: Yunliang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Bank of Blood Products, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, P.R. China.
authors.forename: Lingyan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Neurology, 148 Central Hospital of PLA, Zibo, Shandong 255300, P.R. China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Li
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Tao
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Xingyu
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Hanlin
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Pan
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Limin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Ru
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Danfeng
authors.initials: D
authors.lastname: Lin
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Pan
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Leiting
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Neurology, Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Ye
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
keywords: Parkinson; dopamine receptor D2; dopamine receptor D3; meta-analysis; polymorphism