title: Donor-derived myelodysplastic syndrome and acute leukaemia after allogeneic haematopoietic stem cell transplantation: incidence, natural history and treatment response.
abstract: Donor-derived myelodysplastic syndrome/acute leukaemia (DD-MDS/AL) is a rare life-threatening complication of allogeneic haematopoietic stem cell (HSC) transplantation. However, it is unknown whether the risk differs by HSC source. Therefore, we evaluated the incidence of DD-MDS/AL in 2390 engrafted patients. With a median follow-up of 7·1 years (1-20·8), the incidence of DD-MDS/AL was 0·53% (95% confidence interval (CI), 0·01-1·41%], 0·56% (95%CI, 0·01-1·36%) and 0·56% (95%CI, 0·01-1·10%) in recipients of bone marrow (n = 1117), peripheral blood (n = 489) and umbilical cord blood (UCB, n = 784), respectively. While follow-up is shorter in recipients of UCB and peripheral blood, incidence of DD-MDS/AL is, thus far, similar between HSC sources.
authors.affiliation: Division of Hematology Oncology, and Blood and Marrow Transplant, Department of Pediatrics, Rady Children's Hospital, University of California San Diego, San Diego, CA, USA.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Dietz
authors.forename: Todd E
authors.initials: TE
authors.lastname: DeFor
authors.forename: Claudio G
authors.initials: CG
authors.lastname: Brunstein
authors.forename: John E
authors.initials: JE
authors.lastname: Wagner
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D009190:Myelodysplastic Syndromes / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D014019:Tissue Donors; D016896:Treatment Outcome; D055815:Young Adult
keywords: donor-derived leukaemia; haematopoietic cell transplantation