title: A rare case of internal jugular vein aneurysm with massive hemorrhage in neurofibromatosis type 1.
abstract: Neurofibromatosis Type 1 (NF1) is a relatively common autosomal dominant disorder. Vascular involvement is a well-recognized manifestation of NF1, but venous aneurysm associated with NF1 is extremely rare. We present a case of an NF1 patient with a left internal jugular vein aneurysm with massive hemorrhage occurring during surgery. Due to the extreme fragility of both the aneurismal wall and the surrounding tissue, the patient developed severe intraoperative bleeding. Pathological examination confirmed aneurismal wall infiltration of the neurofibromatosis. Physicians should be aware that hemorrhagic complication in NF1 can occur and be fatal.
authors.affiliation: Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Hiraki
authors.affiliation: Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Electronic address: east@m2.kufm.kagoshima-u.ac.jp.
authors.forename: Michiyo
authors.initials: M
authors.lastname: Higashi
authors.affiliation: Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Goto
authors.affiliation: Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Ikumi
authors.initials: I
authors.lastname: Kitazono
authors.affiliation: Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Seiya
authors.initials: S
authors.lastname: Yokoyama
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iuchi
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Nagano
authors.affiliation: Molecular and Cellular Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Akihide
authors.initials: A
authors.lastname: Tanimoto
authors.affiliation: Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Suguru
authors.initials: S
authors.lastname: Yonezawa
mesh_terms: D000783:Aneurysm / Q000150:complications* / Q000473:pathology / Q000601:surgery; D016063:Blood Loss, Surgical; D006801:Humans; D007601:Jugular Veins / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000473:pathology
keywords: Fatal hemorrhage; Internal jugular vein aneurysm; NF1; Neurofibromatosis; Venous aneurysm