title: Diagnostic value of adenosine deaminase in ascites for tuberculosis ascites: a meta-analysis.
abstract: The diagnosis of tuberculosis (TB) ascites using standard diagnostic tools is difficult. The aim of the present meta-analysis was to establish the overall diagnostic accuracy of adenosine deaminase (ADA) levels in ascites for diagnosing TB ascites. A systematic review was performed of English language publications prior to April 2013. Sensitivity, specificity, and other measures of the accuracy of ADA for the diagnosis of TB ascites using ascites fluid were summarized using a random-effects model or a fixed-effects model. Receiver operating characteristic curves were used to summarize overall test performance. Seventeen studies involving 1797 subjects were eligible for the analysis. The summary estimates of sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and the area under cure of overall analysis were: 0.93, 0.94, 13.55, 0.11, 169.83, and 0.976, respectively; the results of sensitivity analysis of studies that used Giusti method were 0.94, 0.94, 12.99, 0.08, 183.18, and 0.977, respectively. Our results suggest that ADA in the ascites can be a sensitive and specific target and a critical criterion for the diagnosis of TB ascites.
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Tao
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Hong-Jian
authors.initials: HJ
authors.lastname: Ning
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Nie
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Guo
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, PR China. Electronic address: qsy0511@163.com.
authors.forename: Shan-Yu
authors.initials: SY
authors.lastname: Qin
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, PR China. Electronic address: jiangdoc123@sohu.com.
authors.forename: Hai-Xing
authors.initials: HX
authors.lastname: Jiang
mesh_terms: D000243:Adenosine Deaminase / Q000032:analysis*; D001202:Ascitic Fluid / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D014395:Peritonitis, Tuberculous / Q000175:diagnosis* / Q000201:enzymology*; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D000243:Adenosine Deaminase
keywords: Adenosine deaminase; Ascitic fluid; Meta-analysis; Tuberculous