title: Feasibility and preliminary findings from a pilot study of allostatic load in adolescent-young adult childhood cancer survivors and their siblings.
abstract: Adolescent-young adult (AYA) childhood cancer survivors experience at least 2 types of chronic stress that can increase their risk for cardiovascular disease: the physiological stress of cancer and its treatment and the psychosocial stress inherent in the cancer experience. Their siblings can also experience ongoing cancer-related psychosocial stress. The composite biomarker allostatic load (AL) describes the cumulative impact of responses to chronic stress on interrelated organ systems and risk for stress-related diseases including cardiovascular disease. AL could be useful as a surrogate response indicator in research and care that aims to improve cardiovascular outcomes of childhood cancer. However, the measurement of AL has requirements to which AYA might not agree or adhere. This study aimed to (a) evaluate the feasibility of studying AL in AYA cancer populations and (b) briefly describe preliminary findings concerning psychological distress, cancer-related stress symptoms, health behavior and AL in AYA survivors and their siblings within the context of a small pilot study. The results support the feasibility of studying AL in AYA survivors and their siblings, and also suggest that further study of AL and risk for cardiovascular disease in both groups is indicated.
authors.affiliation: 1The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Sheila Judge
authors.initials: SJ
authors.lastname: Santacroce
authors.forename: Jamie B
authors.initials: JB
authors.lastname: Crandell
mesh_terms: D000293:Adolescent; D000328:Adult; D005240:Feasibility Studies; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology* / Q000523:psychology; D010865:Pilot Projects; D035781:Siblings; D013315:Stress, Psychological; D017741:Survivors; D055815:Young Adult
keywords: cardiovascular late effects; posttraumatic stress; psychosocial late effects