title: The association between childhood asthma and adult chronic obstructive pulmonary disease.
abstract: BACKGROUND
  There is epidemiological evidence to suggest that events in childhood influence lung growth and constitute a significant risk for adult COPD. The aim of the study is to evaluate for an association between childhood asthma and adult COPD.
  
  
  METHODS
  This longitudinal, prospective study of 6-7-year-old children with asthma has been regularly reviewed every 7 years to the current analysis at 50 years of age. Participants completed respiratory questionnaires and lung function spirometry with postbronchodilator response. At the age of 50, subjects were classified to the following subgroups: non-asthmatics, asthma remission, current asthma and COPD which was defined by FEV1 to FVC ratio postbronchodilator of less than 0.7.
  
  
  RESULTS
  Of the remaining survivors, 346 participated in the current study (participation rate of 76%) of whom 197 completed both questionnaire and lung function testing. As compared with children without symptoms of wheeze to the age of 7, (non-asthmatics) children with severe asthma had an adjusted 32 times higher risk for developing COPD (95% CI 3.4 to 269). In this cohort, 43% of the COPD group had never smoked. There was no evidence of a difference in the rate of decline in FEV1 (mL/year, 95th CI) between the COPD group (17, 10 to 23) and the other groups: non-asthmatics (16, 12 to 21), asthma remission (20, 16 to 24) and current asthma (19, 13 to 25).
  
  
  CONCLUSIONS
  Children with severe asthma are at increased risk of developing COPD.
authors.affiliation: Department of Respiratory and Sleep Medicine, Women's and Children's Hospital, Adelaide, South Australia, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Tai
authors.affiliation: Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
authors.forename: Haily
authors.initials: H
authors.lastname: Tran
authors.affiliation: Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia.
authors.forename: Mary
authors.initials: M
authors.lastname: Roberts
authors.affiliation: Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
authors.forename: Nadeene
authors.initials: N
authors.lastname: Clarke
authors.affiliation: Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Prahran, Victoria, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Wilson
authors.affiliation: Murdoch Children's Research Institute, Melbourne, Victoria, Australia Respiratory Medicine, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
authors.forename: Colin F
authors.initials: CF
authors.lastname: Robertson
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000150:complications* / Q000453:epidemiology; D001991:Bronchitis / Q000150:complications / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002908:Chronic Disease; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000209:etiology*; D012135:Respiratory Sounds; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014797:Vital Capacity; D055815:Young Adult
keywords: asthma; chronic obstructive pulmonary disease