title: Cutaneous drug reactions in the pediatric population.
abstract: Cutaneous adverse drug reactions (ADRs) constitute a major pediatric health problem frequently encountered in clinical practice, and represent a diagnostic challenge. Children are more susceptible than adults to errors in drug dosage because of their smaller body size; moreover, ADRs can mimic other skin diseases of children, especially viral exanthems. Most ADRs with cutaneous involvement are mild and resolve on withdrawal of the causative drug. The most common forms of cutaneous ADRs, maculopapular exanthems and urticarial reactions, have excellent outcomes. Less frequent but more severe reactions may incur a risk of mortality.
authors.affiliation: Department of Dermatology, University Hospital of the Infant Jesus, Avda. Menéndez Pelayo 65, Madrid 28009, Spain.
authors.forename: Lucero
authors.initials: L
authors.lastname: Noguera-Morel
authors.affiliation: Department of Dermatology, University Hospital of the Infant Jesus, Avda. Menéndez Pelayo 65, Madrid 28009, Spain.
authors.forename: Ángela
authors.initials: Á
authors.lastname: Hernández-Martín
authors.affiliation: Department of Dermatology, University Hospital of the Infant Jesus, Avda. Menéndez Pelayo 65, Madrid 28009, Spain. Electronic address: atorrelo@aedv.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Torrelo
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis* / Q000628:therapy; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000628:therapy; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans
keywords: DRESS syndrome; Drug allergy; Exanthems; Hypersensitivity; Stevens-Johnson syndrome; Toxic epidermal necrolysis; Urticaria