title: Association of promoter genetic variants in interleukin-10 and Kawasaki disease with coronary artery aneurysms.
abstract: BACKGROUND
  Kawasaki disease (KD) is an acute, self-limited vasculitis in infants and young children. Interleukin-10 (IL-10) is a potent cytokine that exerts pleiotropic effects on immunoregulation and inflammation. Elevated IL-10 serum levels have been reported in the KD patients.
  
  
  METHODS
  In this study, we investigated whether IL-10 genetic polymorphisms contribute to coronary artery aneurysm (CAA) development among KD patients in Taiwan. A total of 58 KD patients with CAA and 277 unrelated healthy children matched for sex and age were enrolled for this study.
  
  
  RESULTS
  Higher G allele frequencies of IL-10 at -1082 position were observed in KD patients with CAA compared to the controls (P = 0.016, OR: 2.86, 95% CI, 1.17-6.98). In addition, higher IL-10 GCC haplotype frequencies were also observed in KD patients with CAA (P = 0.016, OR: 2.85, 95% CI, 1.17-6.98).
  
  
  CONCLUSIONS
  Our data support the possibility that IL-10 gene polymorphisms may be related with CAA development of KD in Taiwanese population.
authors.affiliation: Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Ying-Ju
authors.initials: YJ
authors.lastname: Lin
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Lan
authors.forename: Chih-Ho
authors.initials: CH
authors.lastname: Lai
authors.forename: Ting-Hsu
authors.initials: TH
authors.lastname: Lin
authors.forename: Shao-Mei
authors.initials: SM
authors.lastname: Huang
authors.forename: Chiu-Chu
authors.initials: CC
authors.lastname: Liao
authors.forename: Cheng-Wen
authors.initials: CW
authors.lastname: Lin
authors.forename: Chien-Hui
authors.initials: CH
authors.lastname: Hung
authors.forename: Ni
authors.initials: N
authors.lastname: Tien
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
authors.forename: Wen-Kuei
authors.initials: WK
authors.lastname: Chien
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Chen
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000150:complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000235:genetics; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D013624:Taiwan
chemical_list: D016753:Interleukin-10
keywords: Kawasaki disease; coronary artery aneurysms; genetic polymorphism; interleukin-10