title: Histopathological changes in nasal mucosa with nasal septum deviation.
abstract: Histopathological changes in septal and nasal mucosa of patients with nasal septum deviation are not well known. Biopsies of septal and lateral nasal mucosae from both sides of nose were obtained from 20 patients undergoing septoplasty and control group of 10 patients undergoing head and neck surgery. Histopathological changes including lymphocytic infiltration and squamous metaplasia were compared. This study determined significantly higher rate of squamous metaplasia and lymphocytic infiltration in septal mucosa opposite the deviation compared to control group. Furthermore, there was a significantly higher rate of lymphocytic infiltration in the lateral nasal wall mucosa opposite the deviation when compared to control group. Increased lymphocytic infiltration and squamous metaplasia are observed on both sides of nasal mucosa; however, they are more severe on the side opposite the deviation. Septal deviation predisposes to chronic mucosal inflammation and squamous metaplasia, both of which may render patients susceptible to chronic rhinosinusitis.
authors.affiliation: Department of ENT, Queens Medical Centre, Nottingham, UK.
authors.forename: Tawakir
authors.initials: T
authors.lastname: Kamani
authors.forename: Taner
authors.initials: T
authors.lastname: Yılmaz
authors.forename: Selçuk
authors.initials: S
authors.lastname: Sürücü
authors.forename: Münir Demir
authors.initials: MD
authors.lastname: Bajin
authors.forename: Rıza Önder
authors.initials: RÖ
authors.lastname: Günaydın
authors.forename: Oğuz
authors.initials: O
authors.lastname: Kuşçu
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008679:Metaplasia; D009297:Nasal Mucosa / Q000473:pathology*; D009300:Nasal Septum / Q000473:pathology* / Q000601:surgery; D009667:Nose Deformities, Acquired / Q000473:pathology* / Q000601:surgery; D012225:Rhinoplasty; D012852:Sinusitis / Q000473:pathology / Q000601:surgery; D055815:Young Adult