title: Taurolidine locks significantly reduce the incidence of catheter-related blood stream infections in high-risk patients on home parenteral nutrition.
abstract: Emerging evidence suggests taurolidine reduces the risk of repeated episodes of catheter related blood stream infections (CRBSI) in a subgroup of patients receiving home parenteral nutrition (HPN). We defined 3 indications where taurolidine could be considered and retrospectively analysed data from patients who were treated over a 10 year period to examine the validity of these criteria. Twenty-two patients were identified from a total HPN population of 81, representing 33.2 years of experience. The overall CRBSI rate pre- and post-taurolidine usage was reduced from 5.71 to 0.99 infections per 1000 patient parenteral nutrition days (P-value <0.0001), with reductions identified in each smaller subgroup, confirming previous reports of a significant reduction in infections when taurolidine is used as secondary prophylaxis and providing initial data suggesting the benefit of its use as primary prophylaxis.
authors.affiliation: Southampton NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK.
authors.forename: J
authors.initials: J
authors.lastname: Saunders
authors.affiliation: Southampton NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK.
authors.forename: M
authors.initials: M
authors.lastname: Naghibi
authors.affiliation: Department of Nutrition and Dietetics, University Hospital Southampton, Southampton, UK.
authors.forename: Z
authors.initials: Z
authors.lastname: Leach
authors.affiliation: Southampton NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK.
authors.forename: C
authors.initials: C
authors.lastname: Parsons
authors.affiliation: Department of Surgery, University Hospital Southampton, Southampton, UK.
authors.forename: A
authors.initials: A
authors.lastname: King
authors.affiliation: Southampton NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK.
authors.forename: T
authors.initials: T
authors.lastname: Smith
authors.affiliation: Southampton NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK.
authors.forename: M
authors.initials: M
authors.lastname: Stroud
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D016470:Bacteremia / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D055499:Catheter-Related Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D002985:Clinical Protocols; D006801:Humans; D015994:Incidence; D016331:Parenteral Nutrition, Home / Q000009:adverse effects*; D018579:Patient Selection; D012189:Retrospective Studies; D013654:Taurine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013829:Thiadiazines / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D013829:Thiadiazines; D013654:Taurine; C012566:taurolidine