title: Calcium-permeable AMPA receptors in neonatal hypoxic-ischemic encephalopathy (Review).
abstract: Hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and may result in long-term devastating consequences. Excessive stimulation of glutamate receptors (GluRs) is a pivotal mechanism underlying ischemia-induced selective and delayed neuronal death. Although initial studies focused on N-methyl-D-aspartic acid (NMDA) receptors as critical mediators in HIE, subsequent studies supported a more central role for α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs), particularly Ca2+-permeable AMPARs, in brain damage associated with hypoxia-ischemia. This study reviewed the important role of Ca2+-permeable AMPARs in HIE and the future potential neuroprotective strategies associated with Ca2+-permeable AMPARs.
authors.affiliation: Department of Neonatology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215003, P.R. China.
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Tang
authors.affiliation: Department of Neonatology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215003, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xing
keywords: Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; glutamate receptors 2; hypoxic-ischemic encephalopathy; neonate