title: The effect of cisplatin toxicity and capsaicin on electron transport chain in liver and kidney of sprague dawley rats.
abstract: Cisplatin accumulates in mitochondria, which is a potent and widely used chemotherapeutic agent. In order to clarify the potential effect of cisplatin on electron transport chain (ETC), the variation of succinate dehydrogenase (SDH) and cytochrome c oxidase (COX) enzyme activities, nucleotide levels, as well as catalase (CAT) enzyme and membrane lipid peroxidation (LPO) level with respect to liver and kidney of cisplatin-exposed rats were studied. We found that cisplatin caused significant impairment in the SDH, COX, and CAT activities, and nucleotide levels associated with membrane LPO in isolated mitochondria. It was determined whether capsaicin, as an antioxidant, has a possible protective role on all investigated parameters of liver and kidney induced by cisplatin. The results of capsaicin + cisplatin suggest that capsaicin have antioxidant capacity to scavenge ROS to prevent membrane damage.
authors.affiliation: Department of Chemistry, The Graduate School of Natural and Applied Sciences, Dokuz Eylul University, 35160, İzmir, Turkey.
authors.forename: Gizem
authors.initials: G
authors.lastname: Kursunluoglu
authors.forename: Hulya Ayar
authors.initials: HA
authors.lastname: Kayali
authors.forename: Dilek
authors.initials: D
authors.lastname: Taskiran
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002211:Capsaicin / Q000494:pharmacology*; D002945:Cisplatin / Q000009:adverse effects*; D019610:Cytoprotection / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D002945:Cisplatin; D002211:Capsaicin