title: The effect of pharmacologic pupillary dilatation on anterior segment parameters in patients with exfoliation syndrome.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the effect of pharmacologic pupillary dilatation on anterior chamber depth (ACD) and anterior chamber angle (ACA) in eyes with exfoliation syndrome (XFS).
  
  
  METHODS
  Thirty-six eyes of 36 patients with XFS were evaluated with slit-lamp examination, Goldmann applanation tonometry and ultrasound biomicroscopy (UBM) under standard light conditions. Primary outcome parameters were defined as the change in ACD and ACA measured before and 40 min after instillation of a single drop of either 1% cyclopentolate (Group I; n=12), 2.5% phenylephrine (Group II; n=12) or 1% tropicamide (Group III; n=12). Change in intraocular pressure (IOP) during the same time interval was included as a secondary outcome measure.
  
  
  RESULTS
  The average predilatation ACD, ACA and IOP values in the study subjects were 2.54±0.40 mm, 27.9±6.3° and 14.9±3.1 mmHg, respectively. There were no significant differences in the mean age (p=0.461), the female/male ratio (p=0.232), baseline ACD (p=0.841), ACA (p=0.761) or IOP (p=0.070) within the three groups. Differences in dilation induced changes in ACD (p=0.108), ACA (p=0.636) and IOP (p=0.160) between the three groups were not statistically significant.
  
  
  CONCLUSIONS
  Pupillary dilatation with a single drop of 1.0% cyclopentolate, 2.5% phenylephrine or 1% tropicamide is not associated with shallowing of the anterior chamber or narrowing of the ACA in patients with XFS who present with open angles.
authors.affiliation: Hacettepe University School of Medicine, Department of Ophthalmology, Ankara, Turkey. Electronic address: cmocan@hacettepe.edu.tr.
authors.forename: Mehmet Cem
authors.initials: MC
authors.lastname: Mocan
authors.affiliation: Hacettepe University School of Medicine, Department of Ophthalmology, Ankara, Turkey.
authors.forename: Saim
authors.initials: S
authors.lastname: Ustunel
authors.affiliation: Hacettepe University School of Medicine, Department of Ophthalmology, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Dikmetas
authors.affiliation: Selcuk University Faculty of Medicine, Department of Ophthalmology, Konya, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Bozkurt
authors.affiliation: Hacettepe University School of Medicine, Department of Ophthalmology, Ankara, Turkey. Electronic address: mirkec@isnet.net.tr.
authors.forename: Murat
authors.initials: M
authors.lastname: Irkec
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000867:Anterior Chamber / Q000187:drug effects*; D003519:Cyclopentolate / Q000494:pharmacology; D017889:Exfoliation Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009184:Mydriatics / Q000494:pharmacology*; D010656:Phenylephrine / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects* / Q000502:physiology; D014331:Tropicamide / Q000494:pharmacology
chemical_list: D009184:Mydriatics; D010656:Phenylephrine; D003519:Cyclopentolate; D014331:Tropicamide
keywords: Anterior chamber angle; Anterior chamber depth; Biomicroscopia ultrasónica; Dilatación de la pupila; Exfoliation syndrome; Profundidad de la cámara anterior; Pupillary dilatation; Síndrome de exfoliación; Ultrasound biomicroscopy; Ángulo de la cámara anterior