title: Palladium catalyzed N-H bond insertion and intramolecular cyclization cascade: the divergent synthesis of heterocyclics.
abstract: The palladium catalyzed carbenoid based N-H insertion and electronic effect controlled 5-exo-trig or 6-endo-trig mode Heck cyclization in one-pot has been realized for ortho-iodoanilines, in which PdCl2 was used as the single palladium resource. The corresponding indoles and quinolines were obtained respectively. However, for ortho-triflateanilines, base promoted cyclization is preferred and the lactones were obtained.
authors.affiliation: School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun08@gmail.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Ding
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Guangyang
authors.initials: G
authors.lastname: Xu
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Guoping
authors.initials: G
authors.lastname: Wang
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Sun
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D007783:Lactones; D009942:Organometallic Compounds; D010165:Palladium