title: Analysis of the relationship between ultrasound of breast cancer DOT-SDI and the expression of MVD, VEGF and HIF-1α.
abstract: Ultrasonic light scattering tomography system is a new imaging technique for breast function, which associates with diffused optical tomography (DOT) with ultrasonic examination. It locates breast neoplasm with ultrasonic examination and measures the total hemoglobin concentration inside the tumor with DOT photon emission to reflect the metabolic state of tumors and then comes to synthesis diagnostic index to judge benign and malignant tumors. This diagnosis method has significant affection on diagnosis of benign and malignant tumors at home and abroad. In the development of breast cancer, local tissue hypoxia leads to a large number of new blood vessels when the tumor grows faster than the rate of angiogenesis. A recent study found microvessel density (MVD), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 alpha (HIF-1α) play a major role in angiogenesis of breast cancer. This study analyses the relationship between breast cancer ultrasound synthesis diagnostic index (SDI) and the expression of MVD, VEGF and HIF-1α by testing the expression level of the breast cancer gene MVD, VEGF and HIF-1α.
authors.forename: Hai-long
authors.initials: HL
authors.lastname: Wang
authors.forename: Zhou-long
authors.initials: ZL
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D055806:Microvessels / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D041622:Tomography, Optical; D014463:Ultrasonography; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D042461:Vascular Endothelial Growth Factor A