title: [Research progress of Wnt/beta-catenin and nuclear factor-kappa B pathways and their relevance to intervertebral disc degeneration].
abstract: OBJECTIVE
  To review the progress of the mechanisms of Wnt/beta-catenin and nuclear factor-kappa B (NF-kappaB) pathways in the process of the intervertebral disc degeneration.
  
  
  METHODS
  The related literature about the mechanisms of Wnt/beta-catenin and NF-kappaB pathways in the process of the intervertebral disc degeneration was reviewed, analyzed, and summarized.
  
  
  RESULTS
  Wnt/beta-catenin and NF-kappaB pathways are both activated in the process of the intervertebral disc degeneration, and exist interaction. However, the specific mechanisms and interactive mediums of Wnt/beta-catenin and NF-kappaB pathways in the process of the intervertebral disc degeneration are still unclear.
  
  
  CONCLUSIONS
  The mechanisms of Wnt/beta-catenin and NF-kappaB pathways in the process of the intervertebral disc degeneration have to be studied deeply.
authors.forename: Jingbo
authors.initials: J
authors.lastname: Kong
authors.forename: Xinlong
authors.initials: X
authors.lastname: Ma
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Ma
authors.forename: Peng
authors.initials: P
authors.lastname: Tian
authors.forename: Chao
authors.initials: C
authors.lastname: Han
authors.forename: Jiacheng
authors.initials: J
authors.lastname: Zang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Li
authors.forename: Hongqiang
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism* / Q000473:pathology; D055959:Intervertebral Disc Degeneration / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; D016328:NF-kappa B; D051153:Wnt Proteins; D051176:beta Catenin