title: Growth abnormalities in children with type 1 diabetes, juvenile chronic arthritis, and asthma.
abstract: Children and adolescents with chronic diseases are commonly affected by a variable degree of growth failure, leading to an impaired final height. Of note, the peculiar onset during childhood and adolescence of some chronic diseases, such as type 1 diabetes, juvenile idiopathic arthritis, and asthma, underlines the relevant role of healthcare planners and providers in detecting and preventing growth abnormalities in these high risk populations. In this review article, the most relevant common and disease-specific mechanisms by which these major chronic diseases affect growth in youth are analyzed. In addition, the available and potential targeting strategies to restore the physiological, hormonal, and inflammatory pattern are described.
authors.affiliation: Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, 66100-Chieti, Italy ; Center of Excellence on Aging, "G. D'Annunzio" University Foundation, University of Chieti, Via dei Vestini 5, 66100-Chieti, Italy.
authors.forename: Cosimo
authors.initials: C
authors.lastname: Giannini
authors.affiliation: Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, 66100-Chieti, Italy ; Center of Excellence on Aging, "G. D'Annunzio" University Foundation, University of Chieti, Via dei Vestini 5, 66100-Chieti, Italy.
authors.forename: Angelika
authors.initials: A
authors.lastname: Mohn
authors.affiliation: Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, 66100-Chieti, Italy ; Center of Excellence on Aging, "G. D'Annunzio" University Foundation, University of Chieti, Via dei Vestini 5, 66100-Chieti, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Chiarelli