title: Virus-like particles in picornavirus vaccine development.
abstract: Virus-like particles (VLP), which are similar to natural virus particles but do not contain viral genes, have brought about significant breakthroughs in many research fields because of their unique advantages. The ordered repeating epitopes of VLP can induce immunity responses similar to those prompted by natural viral infection; thus, VLP vaccines are regarded as candidate alternatives to whole-virus vaccines. As picornavirus has serious impacts on human and animal health, the development of efficient and safe vaccines is a key endeavor in preventing virus infections. The characteristics of picornavirus capsid proteins allow the development of VLP vaccines. This paper investigates research scenarios and progress on picornavirus VLP vaccines with the aim of providing a reference for researchers focusing on virology and vaccinology.
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou, 730046, People's Republic of China.
authors.forename: Hu
authors.initials: H
authors.lastname: Dong
authors.forename: Hui-Chen
authors.initials: HC
authors.lastname: Guo
authors.forename: Shi-Qi
authors.initials: SQ
authors.lastname: Sun
mesh_terms: D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D006801:Humans; D010849:Picornaviridae / Q000276:immunology*; D010850:Picornaviridae Infections / Q000276:immunology / Q000517:prevention & control*; D058425:Vaccines, Virus-Like Particle / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D058425:Vaccines, Virus-Like Particle; D014765:Viral Vaccines