title: Fungal metabolites with anticancer activity.
abstract: Covering: 1964 to 2013. Natural products from bacteria and plants have played a leading role in cancer drug discovery resulting in a large number of clinically useful agents. In contrast, the investigations of fungal metabolites and their derivatives have not led to a clinical cancer drug in spite of significant research efforts revealing a large number of fungi-derived natural products with promising anticancer activity. Many of these natural products have displayed notable in vitro growth-inhibitory properties in human cancer cell lines and select compounds have been demonstrated to provide therapeutic benefits in mouse models of human cancer. Many of these compounds are expected to enter human clinical trials in the near future. The present review discusses the reported sources, structures and biochemical studies aimed at the elucidation of the anticancer potential of these promising fungal metabolites.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Evidente
authors.forename: Alexander
authors.initials: A
authors.lastname: Kornienko
authors.forename: Alessio
authors.initials: A
authors.lastname: Cimmino
authors.forename: Anna
authors.initials: A
authors.lastname: Andolfi
authors.forename: Florence
authors.initials: F
authors.lastname: Lefranc
authors.forename: Véronique
authors.initials: V
authors.lastname: Mathieu
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D055808:Drug Discovery; D005658:Fungi / Q000737:chemistry*; D006801:Humans; D051379:Mice; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products