title: Association between maternal characteristics, abnormal serum aneuploidy analytes, and placental abruption.
abstract: OBJECTIVE
  The objective of the study was to examine the association between placental abruption, maternal characteristics, and routine first- and second-trimester aneuploidy screening analytes.
  
  
  METHODS
  The study consisted of an analysis of 1017 women with and 136,898 women without placental abruption who had first- and second-trimester prenatal screening results, linked birth certificate, and hospital discharge records for a live-born singleton. Maternal characteristics and first- and second-trimester aneuploidy screening analytes were analyzed using logistic binomial regression.
  
  
  RESULTS
  Placental abruption was more frequent among women of Asian race, age older than 34 years, women with chronic and pregnancy-associated hypertension, preeclampsia, preexisting diabetes, previous preterm birth, and interpregnancy interval less than 6 months. First-trimester pregnancy-associated plasma protein-A of the fifth percentile or less, second-trimester alpha fetoprotein of the 95th percentile or greater, unconjugated estriol of the fifth percentile or less, and dimeric inhibin-A of the 95th percentile or greater were associated with placental abruption as well. When logistic models were stratified by the presence or absence of hypertensive disease, only maternal age older than 34 years (odds ratio [OR], 1.4; 95% confidence interval [CI], 1.0-2.0), pregnancy-associated plasma protein-A of the 95th percentile or less (OR, 1.9; 95% CI, 1.2-3.1), and alpha fetoprotein of the 95th percentile or greater (OR, 2.3; 95% CI, 1.4-3.8) remained statistically significantly associated for abruption.
  
  
  CONCLUSIONS
  In this large, population-based cohort study, abnormal maternal aneuploidy serum analyte levels were associated with placental abruption, regardless of the presence of hypertensive disease.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA. Electronic address: yairb@stanford.edu.
authors.forename: Yair J
authors.initials: YJ
authors.lastname: Blumenfeld
authors.affiliation: Genetic Disease Screening Program, California Department of Public Health, Richmond, CA.
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Baer
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA.
authors.forename: Maurice L
authors.initials: ML
authors.lastname: Druzin
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA.
authors.forename: Yasser Y
authors.initials: YY
authors.lastname: El-Sayed
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA.
authors.forename: Deirdre J
authors.initials: DJ
authors.lastname: Lyell
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Faucett
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
authors.forename: Gary M
authors.initials: GM
authors.lastname: Shaw
authors.affiliation: Genetic Disease Screening Program, California Department of Public Health, Richmond, CA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Currier
authors.affiliation: Genetic Disease Screening Program, California Department of Public Health, Richmond, CA; Division of Preventive Medicine and Public Health, Department of Epidemiology and Biostatistics, University of California, San Francisco, School of Medicine, San Francisco, CA.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Jelliffe-Pawlowski
mesh_terms: D000037:Abruptio Placentae / Q000097:blood* / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D016015:Logistic Models; D008423:Maternal Age; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D011262:Pregnancy Trimester, Second / Q000097:blood; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D012307:Risk Factors; D055815:Young Adult; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D000509:alpha-Fetoproteins; D011266:Pregnancy-Associated Plasma Protein-A
keywords: maternal characteristics; placental abruption; serum analytes