title: Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis.
abstract: OBJECTIVE
  The aim of this study was to explore whether assessment of synovial inflammation by ultrasonography correlates with MRI-proven osteitis in patients with RA.
  
  
  METHODS
  Thirty RA patients who fulfilled 2010 RA classification criteria and were naive to DMARDs, including biologics and glucocorticoids, were consecutively enrolled in this study. Grey scale (GS) and power Doppler (PD) images of articular synovitis and bone erosion in both wrist and MCP joints were evaluated by the method proposed by the European League Against Rheumatism. MRI-proven osteitis of the identical sites was also evaluated within 3 days using the RA MRI scoring system (RAMRIS). The Cochran-Armitage test and Spearman's correlation coefficient were used to investigate the correlation of each US finding with MRI-proven osteitis.
  
  
  RESULTS
  MRI-proven osteitis was found in 8.3% of MCP joints and 48.3% of wrist joints. Its prevalence was increased in the joints where the GS or PD grade of articular synovitis was 2 or 3. In addition, MRI-proven osteitis was found preferentially in the joints positive for bone erosion on US. A clear correlation was demonstrated between the GS or PD grade of articular synovitis or the presence of US bone erosion and RAMRIS osteitis score in both MCP joints and wrist joints.
  
  
  CONCLUSIONS
  Our data indicate that joint injury assessed by US correlates with MRI-proven osteitis in patients with RA.
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan. shin-ya@hotmail.co.jp.
authors.forename: Shin-ya
authors.initials: SY
authors.lastname: Kawashiri
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakashima
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Horai
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Akitomo
authors.initials: A
authors.lastname: Okada
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Nishino
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Iwamoto
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Ichinose
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Arima
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Tamai
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Origuchi
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Uetani
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Aoyagi
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
authors.affiliation: Department of Public Health and Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Center for Health & Community Medicine, Nagasaki University, Department of Health Sciences and Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005384:Finger Joint / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008662:Metacarpophalangeal Joint / Q000000981:diagnostic imaging*; D008875:Middle Aged; D010000:Osteitis / Q000150:complications / Q000473:pathology*; D013585:Synovitis / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D014463:Ultrasonography; D014955:Wrist Joint / Q000473:pathology; D055815:Young Adult
keywords: magnetic resonance imaging; osteitis; rheumatoid arthritis; synovitis; ultrasonography