title: Association of hereditary thrombophilia with intrauterine growth restriction.
abstract: BACKGROUND
  Intrauterine growth retardation (IUGR) contributes significantly to fetal morbidity and mortality, but its etiology is unknown in most cases.
  
  
  OBJECTIVE
  The aim of this study was to examine the association between inherited thrombophilia and IUGR.
  
  
  METHODS
  A case-control study was performed in a tertiary referral center (Afzalipour Hospital) over 2-years period (2010-2011). Cases (n=25) were women who had pregnancies complicated by IUDR and control subjects (n=25) were women who had normal growth fetuses. All women were tested for inherited thrombophilia at least 4 weeks after delivery. Main outcome measure was prevalence of maternal thrombophlia. Genotyping for factor V Leiden, prothrombin gene (nucleotide G20210A), and MTHFR (C677T) mutation was performed by PCR technique. Protein C, S and antithrombin III activity were determined with a clotting assay (STA-Staclot, France).
  
  
  RESULTS
  The prevalence of hereditary thrombophilia was 68% (n=17) in IUGR group, and 32% (n=8) in control group (OR: 1.5, p=0.011, 95% CI: 1.3-14.8). The frequency of MTHFR (C677T) gene mutation (p=0.037; OR: 3.69) and protein S deficiency (p=0.034; OR: 5.41) was significantly increased in the group with IUGR compared with the control group. There was no significant difference between the two groups in prothrombin G20210A mutation (p=0.490) and protein C deficiency (p=0.609). A significant difference in the frequency of multiple thrombophilias was detected between the two groups (p=0.009).
  
  
  CONCLUSIONS
  This study revealed that protein S deficiency and MTHFR gene mutation are more prevalent in pregnancies with IUGR.
authors.affiliation: Department of Obstetrics and Gynecology, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mirzaei
authors.affiliation: Department of Obstetrics and Gynecology, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Farzad-Mahajeri
keywords: Hereditary; Intra uterine growth retardation; Pregnancy; Thrombophilia