title: Pretreatment with Jieduxiezhuo decoction impedes elevations in serum uric acid levels in mice.
abstract: OBJECTIVE
  To investigate whether Jieduxiezhuo decoction (JDXZD) can prevent serum uric acid elevations in mice.
  
  
  METHODS
  Hyperuricemia in mice was induced by intraperitoneally administering uric acid (250 mg/ kg). Concentrations of uric acid in serum were determined using the uric acid enzyme method. Mice were treated with JDXZD for 4 days before uric acid was administered.
  
  
  RESULTS
  After intraperitoneal injection of uric acid, serum uric acid concentrations in mice significantly increased. However, the levels of uric acid in groups pretreated with 16.25 or 4.06 g/kg of JDXZD were significantly lower than those in the model and normal groups.
  
  
  CONCLUSIONS
  Pretreatment with JDXZD slowed increases in serum uric acid levels in mice intraperitoneally administered uric acid.
authors.forename: Yingyi
authors.initials: Y
authors.lastname: Pan
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Chu
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Wang
authors.forename: Baican
authors.initials: B
authors.lastname: Yang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000188:drug therapy / Q000517:prevention & control*; D008297:Male; D051379:Mice; D014527:Uric Acid / Q000097:blood*
chemical_list: D004365:Drugs, Chinese Herbal; D014527:Uric Acid