title: Cardiorespiratory events in extremely low birth weight infants: neurodevelopmental outcome at 1 and 2 years.
abstract: OBJECTIVE
  To examine the association between cardiorespiratory events (CRE) and neurodevelopmental (ND) outcome at 8 and 20 months corrected age (CA) in a contemporary extremely low birth weight (ELBW )cohort.
  
  
  METHODS
  Retrospective chart review of 98 ELBW infants born in 2009 to 2010 who completed ND assessments at 8 and 20 months CA. Neonatal, sociodemographic, CRE and ND data were collected. ND outcome measures included neurologic examination and results from the Bayley Scales of Infant and Toddler Development-III. Multiple regression analyses adjusted for the impact of neonatal risk factors on ND outcome.
  
  
  RESULTS
  After adjusting for neonatal and social variables, greater frequency of CRE was related to worse language scores at 8 months, while CRE of greater severity were related to worse language at 20 months CA.
  
  
  CONCLUSIONS
  CRE in ELBW infants have impact on language development in the first two years of life.
authors.affiliation: 1] Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA [2] Department of Pediatrics, Rush University Medical Center, Chicago, IL, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Greene
authors.affiliation: Department of Pediatrics, Rush University Medical Center, Chicago, IL, USA.
authors.forename: K
authors.initials: K
authors.lastname: Patra
authors.affiliation: Department of Pediatrics, Rush University Medical Center, Chicago, IL, USA.
authors.forename: S
authors.initials: S
authors.lastname: Khan
authors.affiliation: 1] Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA [2] Department of Pediatrics, Rush University Medical Center, Chicago, IL, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Karst
authors.affiliation: 1] Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA [2] Department of Pediatrics, Rush University Medical Center, Chicago, IL, USA.
authors.forename: M N
authors.initials: MN
authors.lastname: Nelson
authors.affiliation: Department of Pediatrics, Rush University Medical Center, Chicago, IL, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Silvestri
mesh_terms: D001049:Apnea / Q000150:complications / Q000453:epidemiology*; D001919:Bradycardia / Q000150:complications / Q000453:epidemiology*; D002657:Child Development; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D052577:Infant, Extremely Low Birth Weight / Q000254:growth & development*; D007231:Infant, Newborn; D007804:Language Development; D008297:Male; D009460:Neurologic Examination; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors