title: The orexin component of fasting triggers memory processes underlying conditioned food selection in the rat.
abstract: To test the selectivity of the orexin A (OXA) system in olfactory sensitivity, the present study compared the effects of fasting and of central infusion of OXA on the memory processes underlying odor-malaise association during the conditioned odor aversion (COA) paradigm. Animals implanted with a cannula in the left ventricle received ICV infusion of OXA or artificial cerebrospinal fluid (ACSF) 1 h before COA acquisition. An additional group of intact rats were food-deprived for 24 h before acquisition. Results showed that the increased olfactory sensitivity induced by fasting and by OXA infusion was accompanied by enhanced COA performance. The present results suggest that fasting-induced central OXA release influenced COA learning by increasing not only olfactory sensitivity, but also the memory processes underlying the odor-malaise association.
authors.affiliation: Centre de Recherche en Neurosciences de Lyon, CNRS UMR 5292, INSERM U 1028, Université Claude Bernard Lyon1, 69366 Lyon, France.
authors.forename: Barbara
authors.initials: B
authors.lastname: Ferry
authors.forename: Patricia
authors.initials: P
authors.lastname: Duchamp-Viret
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001921:Brain / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology; D005215:Fasting / Q000502:physiology*; D005508:Food Deprivation / Q000502:physiology; D005518:Food Preferences / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D009479:Neuropeptides / Q000378:metabolism*; D009483:Neuropsychological Tests; D055696:Olfactory Perception / Q000502:physiology; D000068797:Orexins; D051381:Rats; D020318:Rats, Long-Evans; D012684:Sensory Thresholds / Q000502:physiology; D013647:Task Performance and Analysis; D013997:Time Factors
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins