title: The empirical codon mutation matrix as a communication channel.
abstract: BACKGROUND
  A number of evolutionary models have been widely used for sequence alignment, phylogenetic tree reconstruction, and database searches. These models focus on how sets of independent substitutions between amino acids or codons derive one protein sequence from its ancestral sequence during evolution. In this paper, we regard the Empirical Codon Mutation (ECM) Matrix as a communication channel and compute the corresponding channel capacity.
  
  
  RESULTS
  The channel capacity of 4.1875 bit, which is needed to preserve the information determined by the amino acid distribution, is obtained with an exponential factor of 0.26 applied to the ECM matrix. Additionally, we have obtained the optimum capacity achieving codon distribution. Compared to the biological distribution, there is an obvious difference, however, the distribution among synonymous codons is preserved. More importantly, the results show that the biological codon distribution allows for a "transmission" at a rate very close to the capacity.
  
  
  CONCLUSIONS
  We computed an exponential factor for the ECM matrix that would still allow for preserving the genetic information given the redundancy that is present in the codon-to-amino acid mapping. This gives an insight how such a mutation matrix relates to the preservation of a species in an information-theoretic sense.
authors.forename: Dawit
authors.initials: D
authors.lastname: Nigatu
authors.forename: Attiya
authors.initials: A
authors.lastname: Mahmood
authors.affiliation: School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany. w.henkel@jacobs-university.de.
authors.forename: Werner
authors.initials: W
authors.lastname: Henkel
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D003062:Codon; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D011336:Probability; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA / Q000379:methods*
chemical_list: D000596:Amino Acids; D003062:Codon