title: Licensing of DNA replication, cancer, pluripotency and differentiation: an interlinked world?
abstract: Recent findings provide evidence for a functional interplay between DNA replication and the seemingly distinct areas of cancer, development and pluripotency. Protein complexes participating in DNA replication origin licensing are now known to have roles in development, while their deregulation can lead to cancer. Moreover, transcription factors implicated in the maintenance of or reversal to the pluripotent state have links to the pre-replicative machinery. Several studies have shown that overexpression of these factors is associated to cancer.
authors.affiliation: Department of Physiology, Medical School, University of Patras, Rio, 26504 Patras, Greece. Electronic address: schamperis@upatras.gr.
authors.forename: S
authors.initials: S
authors.lastname: Champeris Tsaniras
authors.affiliation: Department of Physiology, Medical School, University of Patras, Rio, 26504 Patras, Greece. Electronic address: kanellakis@upatras.gr.
authors.forename: N
authors.initials: N
authors.lastname: Kanellakis
authors.affiliation: Department of Biology, Medical School, University of Patras, Rio, 26504 Patras, Greece. Electronic address: eleannasym@googlemail.com.
authors.forename: I E
authors.initials: IE
authors.lastname: Symeonidou
authors.affiliation: Department of Physiology, Medical School, University of Patras, Rio, 26504 Patras, Greece. Electronic address: pinelopinik@hotmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Nikolopoulou
authors.affiliation: Department of Biology, Medical School, University of Patras, Rio, 26504 Patras, Greece. Electronic address: lygerou@med.upatras.gr.
authors.forename: Z
authors.initials: Z
authors.lastname: Lygerou
authors.affiliation: Department of Physiology, Medical School, University of Patras, Rio, 26504 Patras, Greece. Electronic address: taraviras@med.upatras.gr.
authors.forename: S
authors.initials: S
authors.lastname: Taraviras
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004261:DNA Replication; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000502:physiology; D039904:Pluripotent Stem Cells / Q000502:physiology
keywords: Cancer; DNA replication; Development; Licensing; Origin specification; Pluripotency