title: Novel gonadal characteristics in an aged bovine freemartin.
abstract: The gonads from a five-year-old freemartin Holstein animal were subjected to morphological analysis and to immunohistochemistry using antibodies against developmental and functional markers. We demonstrate, for the first time, the retention of anti-mullerian hormone (AMH) producing intratubular cells (Sertoli cells) in the context of abundant steroidogenic interstitial cells, and structures consistent with clusters of luteal cells. This novel report describes the clinical, gross and histological findings accompanying this newly described gonadal immunophenotype, and its implication in the understanding of freemartin development.
authors.affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, United Kingdom. Electronic address: john.remnant@nottingham.ac.uk.
authors.forename: J G
authors.initials: JG
authors.lastname: Remnant
authors.affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, United Kingdom.
authors.forename: R G
authors.initials: RG
authors.lastname: Lea
authors.affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, United Kingdom.
authors.forename: C E
authors.initials: CE
authors.lastname: Allen
authors.affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, United Kingdom.
authors.forename: J N
authors.initials: JN
authors.lastname: Huxley
authors.affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, United Kingdom.
authors.forename: R S
authors.initials: RS
authors.lastname: Robinson
authors.affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, United Kingdom.
authors.forename: A I
authors.initials: AI
authors.lastname: Brower
mesh_terms: D000375:Aging; D000818:Animals; D002417:Cattle; D005260:Female; D005611:Freemartinism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010053:Ovary / Q000254:growth & development / Q000473:pathology*; D013737:Testis / Q000254:growth & development / Q000473:pathology*
keywords: Anti-mullerian hormone (AMH); Bovine; CYP17A1; Freemartin; Gonad