title: New diamino-diheterophenol ligands coordinate iron(III) to make structural and functional models of protocatechuate 3,4-dioxygenase.
abstract: Three diamino, dihetero-phenol ligands were synthesized by sequential Mannich condensations. These ligands were combined with FeCl3 to produce three five-coordinate Fe(III) complexes that are structural models for the enzyme 3,4-PCD. The three Fe(III) complexes were characterized by elemental analysis, single crystal X-ray diffraction studies, UV-vis spectroscopy, and cyclic voltammetry. Combining the Fe(III) complexes with 3,5-di-t-butylcatechol and O2 resulted in oxidative cleavage similar to the function of 3,4-PCD.
authors.affiliation: Department of Chemistry, College of the Holy Cross, Worcester, MA 01610, USA.
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Farrell
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Niconchuk
authors.forename: Peter R
authors.initials: PR
authors.lastname: Renehan
authors.forename: Christine S
authors.initials: CS
authors.lastname: Higham
authors.forename: Eric
authors.initials: E
authors.lastname: Yoon
authors.forename: Mark V
authors.initials: MV
authors.lastname: Andrews
authors.forename: Janet L
authors.initials: JL
authors.lastname: Shaw
authors.forename: Anil
authors.initials: A
authors.lastname: Cetin
authors.forename: James
authors.initials: J
authors.lastname: Engle
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Ziegler
mesh_terms: D018360:Crystallography, X-Ray; D003959:Diamines / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D011520:Protocatechuate-3,4-Dioxygenase / Q000737:chemistry* / Q000378:metabolism
chemical_list: D003959:Diamines; D008024:Ligands; D010636:Phenols; D011520:Protocatechuate-3,4-Dioxygenase