title: Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response.
abstract: Angiotensin-converting enzyme (ACE) plays an important role in blood pressure control. ACE also has effects on renal function, reproduction, hematopoiesis, and several aspects of the immune response. ACE 10/10 mice overexpress ACE in monocytic cells; macrophages from ACE 10/10 mice demonstrate increased polarization toward a proinflammatory phenotype. As a result, ACE 10/10 mice have a highly effective immune response following challenge with melanoma, bacterial infection, or Alzheimer disease. As shown in ACE 10/10 mice, enhanced monocytic function greatly contributes to the ability of the immune response to defend against a wide variety of antigenic and non-antigenic challenges.
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Bernstein
authors.forename: Romer A
authors.initials: RA
authors.lastname: Gonzalez-Villalobos
authors.forename: Jorge F
authors.initials: JF
authors.lastname: Giani
authors.forename: Kandarp
authors.initials: K
authors.lastname: Shah
authors.forename: Ellen
authors.initials: E
authors.lastname: Bernstein
authors.forename: Tea
authors.initials: T
authors.lastname: Janjulia
authors.forename: Yosef
authors.initials: Y
authors.lastname: Koronyo
authors.forename: Peng D
authors.initials: PD
authors.lastname: Shi
authors.forename: Maya
authors.initials: M
authors.lastname: Koronyo-Hamaoui
authors.forename: Sebastien
authors.initials: S
authors.lastname: Fuchs
authors.forename: Xiao Z
authors.initials: XZ
authors.lastname: Shen
mesh_terms: D000818:Animals; D042381:Granulocyte Precursor Cells / Q000201:enzymology* / Q000276:immunology*; D007111:Immunity, Cellular / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis* / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A