title: A capsule conjugate vaccine approach to prevent diarrheal disease caused by Campylobacter jejuni.
abstract: Campylobacter jejuni is a major cause of diarrheal disease and results in high levels of morbidity and economic loss in both industrialized and developing regions of the world. To date, prior vaccine approaches have failed to confer protection against this enteric pathogen. Key challenges to the development of a practical Campylobacter vaccine for human use include a lack of understanding of Campylobacter pathogenesis and well-defined immune correlates of protection. With the discovery that C. jejuni expresses a capsule polysaccharide associated with virulence, a conjugate vaccine approach is currently being evaluated. Conjugate vaccines have been successfully developed and implemented against other invasive mucosal pathogens including Streptococcus pneumoniae, Neisseria meningitidis, and Hemophilus influenzae. Furthermore, Shigella-based conjugate vaccines based on lipopolysaccharide have shown promising results in field trials. A prototype C. jejuni conjugate vaccine is currently entering human testing.
authors.affiliation: Enteric Diseases Department; Naval Medical Research Center; Silver Spring, MD USA.
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Maue
authors.affiliation: Enteric Diseases Department; Naval Medical Research Center; Silver Spring, MD USA.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Poly
authors.affiliation: Enteric Diseases Department; Naval Medical Research Center; Silver Spring, MD USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Guerry
mesh_terms: D016667:Bacterial Capsules / Q000276:immunology*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D002169:Campylobacter Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D016123:Campylobacter jejuni / Q000276:immunology*; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D055808:Drug Discovery / Q000639:trends; D006801:Humans; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology / Q000302:isolation & purification
chemical_list: D001428:Bacterial Vaccines; D018074:Vaccines, Conjugate
keywords: Campylobacter; GBS; capsular polysaccharide; conjugate vaccines; diarrheal disease