title: Platelet myosin light chain phosphatase: keeping it together.
abstract: MLCP (myosin light chain phosphatase) regulates platelet function through its ability to control myosin IIa phosphorylation. Recent evidence suggests that MLCP is a de facto target for signalling events stimulated by cAMP. In the present mini-review, we discuss the mechanisms by which cAMP signalling maintains MLCP in an active state to control platelet contractile machinery.
authors.affiliation: *Thrombosis Research Laboratory, Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Lab 013/014, Hardy Building, University of Hull, Cottingham Road, Hull HU6 7RX, U.K.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Aburima
authors.affiliation: *Thrombosis Research Laboratory, Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Lab 013/014, Hardy Building, University of Hull, Cottingham Road, Hull HU6 7RX, U.K.
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Naseem
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D006801:Humans; D043263:Myosin-Light-Chain Phosphatase / Q000378:metabolism*; D054460:rho-Associated Kinases / Q000378:metabolism*
chemical_list: D054460:rho-Associated Kinases; D017868:Cyclic AMP-Dependent Protein Kinases; D043263:Myosin-Light-Chain Phosphatase