title: Potential protective effect of highly bioavailable curcumin on an oxidative stress model induced by microinjection of sodium nitroprusside in mice brain.
abstract: Curcumin, a polyphenolic compound has several pharmacological activities, such as anticancer, anti-inflammatory and antioxidant effects. However, curcumin shows poor oral bioavailability. The purpose of this study was to investigate the protective effects of highly bioavailable curcumin, Theracurmin(®), and curcumin, against sodium nitroprusside (SNP)-induced oxidative damage in mice brain. Intrastriatal microinjection of Theracurmin(®) or curcumin with SNP significantly protected against SNP-induced brain damage and motor dysfunction. Oral administration of Theracurmin(®) (1 and 3 g kg(-1), containing 100 and 300 mg kg(-1) curcumin, respectively) significantly protected against SNP-induced brain damage and motor dysfunction. However, oral administration of 300 mg kg(-1) curcumin did not protect against motor dysfunction induced by SNP. These results suggest that curcumin and Theracurmin(®) have protective effects against SNP-induced oxidative damage. Moreover, oral administration of Theracurmin(®), had more potency in protecting against brain damage, suggesting a higher bioavailability of Theracurmin(®) following oral administration.
authors.affiliation: Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimoadachi-cho, Sakyo-Ku, Kyoto 606-8501, Japan. tkume@pharm.kyoto-u.ac.jp.
authors.forename: Qand Agha
authors.initials: QA
authors.lastname: Nazari
authors.forename: Yuki
authors.initials: Y
authors.lastname: Takada-Takatori
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Imaizumi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Izumi
authors.forename: Akinori
authors.initials: A
authors.lastname: Akaike
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kume
mesh_terms: D000818:Animals; D001682:Biological Availability; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003474:Curcumin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009599:Nitroprusside / Q000008:administration & dosage / Q000009:adverse effects; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D018696:Neuroprotective Agents; D009599:Nitroprusside; D003474:Curcumin