title: Oxidative stress: meeting multiple targets in pathogenesis of diabetic nephropathy.
abstract: Excessive production of reactive oxygen species is an important mechanism underlying the pathogenesis of diabetes associated macrovascular and microvascular complications including diabetic nephropathy. Diabetic nephropathy is characterized by glomerular enlargement, early albuminuria and progressive glomerulosclerosis. The pathogenesis of diabetic nephropathy is multi-factorial and the precise mechanisms are unclear. Hyperglycemia-mediated dysregulation of various pathways either enhances the intensity of oxidative stress or these pathways are affected by oxidative stress. Thus, oxidative stress has been considered as a central mediator in progression of nephropathy in patients with diabetes. In this review, we have focused on current perspectives in oxidative stress signaling to determine common biological processes whereby diabetes-induced oxidative stress plays a central role in progression of diabetic nephropathy.
authors.forename: Mandeep Kumar
authors.initials: MK
authors.lastname: Arora
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Swami Vivekanand Subharti University, Meerut 250005, Uttar Pradesh, India. mmmarora2@gmail.com.
authors.forename: Umesh Kumar
authors.initials: UK
authors.lastname: Singh
mesh_terms: D000818:Animals; D003928:Diabetic Nephropathies / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species