title: Association of annexin A5 polymorphisms with obesity.
abstract: Annexin A5 (ANXA5), which is known as a protein with anticoagulative function, may play a role in triglyceride biosynthesis. Triglycerides are involved in lipid and energy metabolism, which are important in the elucidation of obesity. To investigate the association between single-nucleotide polymorphisms (SNPs) ofANXA5and obesity in a Korean population, 372 participants (213 overweight/obese individuals and 159 control subjects) were enrolled from the Kyung Hee University Medical Center and Keimyung University Dongsan Medical Center. The genotypes of five SNPs (rs12510548, rs4240260, rs3756281, rs13136094 and rs6534313) were evaluated inANXA5using the multiple logistic regression analysis with the codominant 1, codominant 2, dominant, recessive and log-additive models. The genotype and allele frequencies of the five investigated SNPs exhibited significant differences between the control and the overweight/obese groups: rs12510548 (P=0.004 in the codominant 2 model, P=0.0019 in the recessive model, P=0.027 in the log-additive model and P=0.026 in allele frequencies); rs4240260 (P=0.002 and Fisher's exact P=0.0006 in the codominant 2 model, P=0.0007 and Fisher's exact P=0.0007 in the recessive model, P=0.020 and Fisher's exact P=0.0019 in the log-additive model and P=0.020 in allele frequencies); rs3756281 (P=0.016 in the codominant 2 model and P=0.0094 in the recessive model); rs13136094 (P=0.0030 and Fisher's exact P=0.0011 in the codominant 2 model, P=0.0012 and Fisher's exact P=0.0013 in the recessive model, P=0.034 and Fisher's exact P=0.0035 in the log-additive model and P=0.024 in allele frequencies); and rs6534313 (P=0.0010 and Fisher's exact P=0.0003 in the codominant 2 model, P=0.0003 and Fisher's exact P=0.0003 in the recessive model, P=0.0075 and Fisher's exact P=0.0010 in the log-additive model and P=0.005 in allele frequencies). Two haplotypes were weakly associated with obesity (GGATG, P=0.037 and CAGCC, P=0.020). Results of the present study suggested thatANXA5may be associated with the development of obesity in a Korean population.
authors.affiliation: Departments of Pharmacology and Kohwang Medical Research Institute, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Hosik
authors.initials: H
authors.lastname: Seok
authors.affiliation: Departments of Pharmacology and Kohwang Medical Research Institute, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Biochemistry and Molecular Biology, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Byoung Wook
authors.initials: BW
authors.lastname: Lee
authors.affiliation: Neuropsychiatry, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Orthodontics, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Min
authors.initials: M
authors.lastname: Jung
authors.affiliation: Department of Orthodontics, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Seo Ra
authors.initials: SR
authors.lastname: Lee
authors.affiliation: Department of Orthodontics, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
authors.affiliation: Department of Orthodontics, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Young Guk
authors.initials: YG
authors.lastname: Park
authors.affiliation: Biochemistry and Molecular Biology, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Hyung Hwan
authors.initials: HH
authors.lastname: Baik
authors.affiliation: Departments of Pharmacology and Kohwang Medical Research Institute, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
keywords: annexin A5; haplotype; obesity; single-nucleotide polymorphism