title: Perioperative management of acquired hemophilia a: a case report and review of literature.
abstract: BACKGROUND
  Acquired hemophilia A is a rare bleeding disorder with a high mortality rate. Diagnosis and treatment of this disorder can be very challenging to anesthesiologists because of lack of a personal or familial abnormal bleeding history.
  
  
  METHODS
  We report a 60-year-old woman who presented to the operating room for an urgent fasciotomy. She was initially diagnosed to have compartment syndrome of her left upper extremity secondary to an expanding hematoma after multiple unsuccessful venipuncture attempts. After surgical intervention, she developed recurrent intramuscular hematomas, became severely anemic, and required surgical re-exploration and multiple blood product transfusions. Ultimately, she was found to have an elevated activated partial thromboplastin time (aPTT), very low FVIII activity, and high FVIII inhibitor titers consistent with the diagnosis of acquired hemophilia A.
  
  
  CONCLUSIONS
  Treatment strategies in acquired hemophilia are based on two major objectives. During the acute stage, effective control of bleeding is critical. The ultimate therapeutic goal during the subacute phase is the elimination of the inhibitors targeting factor VIII. Here, we present this case and will review current literature regarding therapeutic approaches to this rare condition in the operating room setting and postoperative course.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, School of Medicine, University of New Mexico, Albuquerque, USA.
authors.forename: Yashar
authors.initials: Y
authors.lastname: Ilkhchoui
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, School of Medicine, University of New Mexico, Albuquerque, USA.
authors.forename: Eugene
authors.initials: E
authors.lastname: Koshkin
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, School of Medicine, University of New Mexico, Albuquerque, USA.
authors.forename: Jimmy J
authors.initials: JJ
authors.lastname: Windsor
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, School of Medicine, University of New Mexico, Albuquerque, USA.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Petersen
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, School of Medicine, University of New Mexico, Albuquerque, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Charles
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, School of Medicine, University of New Mexico, Albuquerque, USA.
authors.forename: Jeffery D
authors.initials: JD
authors.lastname: Pack
keywords: Factor Eight Inhibitor Bypassing Activity; Immunosuppressive Agents; Perioperative Care