title: Cytopathological features of mammary analogue secretory carcinoma--review of literature.
abstract: Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that morphologically resembles mammary secretory carcinoma and carries the identical ETV6-NTRK3 fusion gene. We report a surgical resected case of MASC in the parotid gland of a 41-year-old man. The cytological smears of a preoperative fine-needle aspiration showed many sheets and crowded clusters of monotonous epithelioid cells with mild atypia, suggestive of monomorphic tumor. Histologically, the tumor was composed of cuboidal cells with follicular, tubular, and solid structures, reminiscent of acinic cell carcinoma of follicular variant, which had been previously classified. This case had ETV6-NTRK3 fusion gene transcript confirmed by fluorescence in situ hybridization and reverse transcription polymerase chain reaction. In the cytological and histopathological diagnosis of monomorphic tumor of salivary gland, MASC needs to be taken into consideration as a differential diagnosis. Further immunohistochemical and gene analyses are needed in diagnosis of MASC.
authors.affiliation: Department of Diagnostic Pathology, Nara Medical University, Kashihara, Nara, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Takeda
authors.forename: Takahiko
authors.initials: T
authors.lastname: Kasai
authors.forename: Kohei
authors.initials: K
authors.lastname: Morita
authors.forename: Mao
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Akinori
authors.initials: A
authors.lastname: Yamashita
authors.forename: Shinji
authors.initials: S
authors.lastname: Mikami
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hosoi
authors.forename: Chiho
authors.initials: C
authors.lastname: Ohbayashi
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D020812:Receptor, trkC; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D015514:Oncogene Proteins, Fusion; C484319:ETV6-NTRK3 fusion protein, human; D020812:Receptor, trkC; D000097764:ETS Translocation Variant 6 Protein
keywords: ETV6-NTRK3 fusion transcript; Mammary analogue secretory carcinoma; fine-needle aspiration; salivary gland