title: Is the interleukin 8 promoter polymorphism rs4073/-251T >A associated with Clostridium difficile infection?
abstract: The interleukin 8 gene single-nucleotide polymorphism rs4073/-251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/-251T >A is unlikely to constitute a major risk factor for CDI.
authors.affiliation: Wolfson Centre for Personalised Medicine, University of Liverpool Royal Liverpool and Broadgreen University Hospital NHS Trust.
authors.forename: Fabio
authors.initials: F
authors.lastname: Miyajima
authors.affiliation: Wolfson Centre for Personalised Medicine, University of Liverpool Royal Liverpool and Broadgreen University Hospital NHS Trust.
authors.forename: Andrew
authors.initials: A
authors.lastname: Swale
authors.affiliation: Wolfson Centre for Personalised Medicine, University of Liverpool.
authors.forename: J Eunice
authors.initials: JE
authors.lastname: Zhang
authors.affiliation: Wolfson Centre for Personalised Medicine, University of Liverpool.
authors.forename: Ana
authors.initials: A
authors.lastname: Alfirevic
authors.affiliation: Wolfson Centre for Personalised Medicine, University of Liverpool Royal Liverpool and Broadgreen University Hospital NHS Trust.
authors.forename: Margaret
authors.initials: M
authors.lastname: Little
authors.affiliation: Royal Liverpool and Broadgreen University Hospital NHS Trust Liverpool School of Tropical Medicine.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Beeching
authors.affiliation: Royal Liverpool and Broadgreen University Hospital NHS Trust.
authors.forename: Godfrey
authors.initials: G
authors.lastname: Smith
authors.affiliation: Department of Biostatistics, University of Liverpool, United Kingdom.
authors.forename: Ruwanthi
authors.initials: R
authors.lastname: Kolamunnage-Dona
authors.affiliation: Wolfson Centre for Personalised Medicine, University of Liverpool Royal Liverpool and Broadgreen University Hospital NHS Trust.
authors.forename: Munir
authors.initials: M
authors.lastname: Pirmohamed
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D016022:Case-Control Studies; D016360:Clostridioides difficile; D003967:Diarrhea / Q000139:chemically induced / Q000235:genetics; D004761:Enterocolitis, Pseudomembranous / Q000235:genetics*; D005243:Feces / Q000737:chemistry; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D016209:Interleukin-8
keywords: Clostridium difficile; genetic predisposition; host response; interleukin 8; meta-analysis