title: Systematic survey of the dose enhancement in tissue-equivalent materials facing medium- and high-Z backscatterers exposed to X-rays with energies from 5 to 250 keV.
abstract: The present study has been inspired by the results of earlier dose measurements in tissue-equivalent materials adjacent to thin foils of aluminum, copper, tin, gold, and lead. Large dose enhancements have been observed in low-Z materials near the interface when this ensemble was irradiated with X-rays of qualities known from diagnostic radiology. The excess doses have been attributed to photo-, Compton, and Auger electrons released from the metal surfaces. Correspondingly, high enhancements of biological effects have been observed in single cell layers arranged close to gold surfaces. The objective of the present work is to systematically survey, by calculation, the values of the dose enhancement in low-Z media facing backscattering materials with a variety of atomic numbers and over a large range of photon energies. Further parameters to be varied are the distance of the point of interest from the interface and the kind of the low-Z material. The voluminous calculations have been performed using the PHOTCOEF algorithm, a proven set of interpolation functions fitted to long-established Monte Carlo results, for primary photon energies between 5 and 250 keV and for atomic numbers varying over the periodic system up to Z = 100. The calculated results correlate well with our previous experimental results. It is shown that the values of the dose enhancement (a) vary strongly in dependence upon Z and photon energy; (b) have maxima in the energy region from 40 to 60 keV, determined by the K and L edges of the backscattering materials; and (c) are valued up to about 130 for "International Commission on Radiological Protection (ICRP) soft tissue" (soft tissue composition recommended by the ICRP) as the adjacent low-Z material. Maximum dose enhancement associated with the L edge occurs for materials with atomic numbers between 50 and 60, e.g., barium (Z = 56) and iodine (Z = 53). Such materials typically serve as contrast media in medical X-ray diagnostics. The gradual reduction in the dose enhancement with increasing distance from the material interface, owed to the limited ranges of the emitted secondary electrons, has been documented in detail. The discussion is devoted to practical radiological aspects of the dose enhancement phenomenon. Cytogenetic effects in cell layers closely proximate to surfaces of medium-Z materials might vary over two orders of magnitude, because the dose enhancement is accompanied by the earlier observed about twofold increase in the low-dose RBEM at a tissue-to-gold interface.
authors.affiliation: Paediatric Radiology, Institute for Clinical Radiology, Dr. von Hauner's Children's Hospital, Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337, Munich, Germany, michael.seidenbusch@med.uni-muenchen.de.
authors.forename: M
authors.initials: M
authors.lastname: Seidenbusch
authors.forename: D
authors.initials: D
authors.lastname: Harder
authors.forename: D
authors.initials: D
authors.lastname: Regulla
mesh_terms: D000465:Algorithms; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D017785:Photons; D011874:Radiometry / Q000295:instrumentation*; D012542:Scattering, Radiation; D014965:X-Rays