title: [Association and interaction of AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R and PTGS2 genes on the risk of hypertension in Antioquian population].
abstract: BACKGROUND
  Hypertension is a multifactorial disease influenced by genetic and environmental components, with its prevalence varying across ethnic groups. Manifold studies on blood pressure regulatory system genes have been carried out -such as the renin-angiotensin-aldosterone system, the sympathetic nervous system, endothelial factor, and sodium balance-, but the results yielded were inconsistent among populations.
  
  
  OBJECTIVE
  To evaluate the effect of both variants in genes AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R PTGS2, and the result of the individual ancestry component on hypertension and blood pressure levels among population in Antioquia.
  
  
  METHODS
  107 cases and 253 controls were genotyped for 12 variants on genes AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R y PTGS2, and for 20 ancestry informative markers. The association of polymorphisms and their interactions, and the association of ancestral genetic composition with hypertension and blood pressure levels were examined.
  
  
  RESULTS
  Genes ADD2, rs4852706 (OR=3.0; p=0.023); DRD1, rs686 (OR=0.38; p=0.012) and ADRB2, rs1042718 (OR=10.0; p=0.008); as well as genotypic combinations of DRD1 and AGTR1; AGT and ADD1; and ADD1 to ATP2B1 and PTGS2 were associated to hypertension. The Amerindian ancestry component was associated to some decrease in diastolic blood pressure.
  
  
  CONCLUSIONS
  Variants on genes ADD2, DRD1, ADRB2, AGTR1, AGT, ADD1, ATP2B1 and PTGS2 individually or interacting, are associated to hypertension. The Amerindian ancestry component has an effect on blood pressure.
authors.affiliation: Grupo de Genética Molecular, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Diana María
authors.initials: DM
authors.lastname: Valencia
authors.affiliation: Grupo de Genética Molecular, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Carlos Andrés
authors.initials: CA
authors.lastname: Naranjo
authors.affiliation: Grupo de Genética Molecular, Universidad de Antioquia, Medellín, Colombia.
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Parra
authors.affiliation: Grupo de Genética Molecular, Universidad de Antioquia, Medellín, Colombia.
authors.forename: María Antonieta
authors.initials: MA
authors.lastname: Caro
authors.affiliation: Grupo de Genética Molecular, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Ana Victoria
authors.initials: AV
authors.lastname: Valencia
authors.affiliation: Hospital Universitario San Vicente de Paúl, Universidad de Antioquia.
authors.forename: Carlos José
authors.initials: CJ
authors.lastname: Jaramillo
authors.affiliation: Grupo de Genética Molecular, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Bedoya
mesh_terms: D000328:Adult; D000808:Angiotensinogen / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics; D002148:Calmodulin-Binding Proteins / Q000235:genetics; D003105:Colombia; D051546:Cyclooxygenase 2 / Q000235:genetics; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000235:genetics; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics; D017447:Receptors, Dopamine D1 / Q000235:genetics; D044244:Receptors, Thromboxane A2, Prostaglandin H2 / Q000235:genetics; D012307:Risk Factors; D000099291:Adducins
chemical_list: D000808:Angiotensinogen; D002148:Calmodulin-Binding Proteins; D051546:Cyclooxygenase 2; D007703:Peptidyl-Dipeptidase A; D053499:Plasma Membrane Calcium-Transporting ATPases; D044140:Receptor, Angiotensin, Type 1; D018343:Receptors, Adrenergic, beta-2; D017447:Receptors, Dopamine D1; D044244:Receptors, Thromboxane A2, Prostaglandin H2; D000099291:Adducins; C553443:ADRB2 protein, human; C534931:AGT protein, human; C544065:AGTR1 protein, human; C506952:ATP2B1 protein, human; C583260:DRD1 protein, human; C496540:PTGS2 protein, human; C488034:ACE protein, human