title: Graphene oxide functionalized with silver@silica-polyethylene glycol hybrid nanoparticles for direct electrochemical detection of quercetin.
abstract: A direct electrochemical detection of quercetin based on functionalized graphene oxide modified on gold-printed circuit board chip was demonstrated in this study. Functionalized graphene oxide materials are prepared by the covalent reaction of graphene oxide with silver@silica-polyethylene glycol nanoparticles (~12.35nm). Functionalized graphene oxide electrode shows a well-defined voltammetric response in phosphate buffered saline and catalyzes the oxidation of quercetin to quinone without the need of an enzyme. Significantly, the functionalized graphene oxide modified electrode exhibited a higher sensitivity than pristine gold-printed circuit board and graphene oxide electrodes, a wide concentration range of 7.5 to 1040nM and detection limit of 3.57nM. Developed biosensor platform is selective toward quercetin in the presence of an interferent molecule.
authors.affiliation: Department of Bionanotechnology, Gachon University, Gyeonggi-Do 461-701, Republic of Korea; Department of Chemistry, University of Montreal, CP 6128, Succursale Centre-ville, Montreal, QC H3C 3J7, Canada.
authors.forename: Murugan
authors.initials: M
authors.lastname: Veerapandian
authors.affiliation: School of Electrical Engineering and Computer Science, Seoul National University, Seoul 151-600, Republic of Korea.
authors.forename: Yeong-Tai
authors.initials: YT
authors.lastname: Seo
authors.affiliation: Department of Bionanotechnology, Gachon University, Gyeonggi-Do 461-701, Republic of Korea. Electronic address: ykyusik@gachon.ac.kr.
authors.forename: Kyusik
authors.initials: K
authors.lastname: Yun
authors.affiliation: Korea Electronics Technology Institute, Medical IT Technology, Gyeonggi-Do 463-816, Republic of Korea. Electronic address: mhlee@keti.re.kr.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Lee
mesh_terms: D003217:Conductometry / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006108:Graphite / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008839:Microelectrodes; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011794:Quercetin / Q000032:analysis*; D012822:Silicon Dioxide / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
chemical_list: D010087:Oxides; D012834:Silver; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D006108:Graphite; D011794:Quercetin
keywords: Chemical functionalization; Graphene oxide; Hybrid nanoparticles; Quercetin biosensor