title: [Prognostic analysis of children with Henoch-Schonlein purpura treated by Helicobacter pylori eradication therapy].
abstract: OBJECTIVE
  To investigate the effect of Helicobacter pylori (Hp) eradication therapy on prognosis in children with Henoch-Schonlein purpura (HSP).
  
  
  METHODS
  A total of 153 children with HSP were divided into Hp infection treatment group (n=22), Hp infection control group (n=21), and Hp infection-negative group (n=110). The Hp infection treatment group received one-week triple therapy for Hp eradication in addition to conventional treatment, while the Hp infection control group and Hp infection-negative group received conventional treatment. All patients were followed up for prognostic evaluation.
  
  
  RESULTS
  The response rates of the Hp infection treatment, control, and negative groups were 86% (19/22), 90% (19/21) and 85% (94/110), respectively (P>0.05). The recurrence rates of HSP in the Hp infection treatment, control, and negative groups were 14% (3/22), 24% (5/21) and 31% (34/110), respectively (P>0.05). The incidence of Henoch-Schonlein purpura nephritis (HSPN) in the Hp infection-negative group (36%, 40/110) and control group (33%, 7/21) was significantly higher than that in the Hp infection treatment group (5%, 1/22) (P<0.05 for both), but no significant difference in the incidence of HSPN was found between the control and negative groups (P>0.05).
  
  
  CONCLUSIONS
  One-week triple therapy for Hp eradication may be useful to reduce the incidence of HSPN in children with HSP infected with Hp.
authors.affiliation: Department of Gastroenterology, Shenzhen Children's Hospital, Chongqing Medical University, Shenzhen, Guangdong 518026, China. liyongbai@sina.com).
authors.forename: Hua-Bo
authors.initials: HB
authors.lastname: Cai
authors.forename: Yong-Bai
authors.initials: YB
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Shao-Ming
authors.initials: SM
authors.lastname: Zhou
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zhao
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D011695:IgA Vasculitis / Q000453:epidemiology* / Q000209:etiology; D015994:Incidence; D008297:Male; D011379:Prognosis; D012008:Recurrence