title: GABA-mediated presynaptic inhibition is required for precision of long-term memory.
abstract: Though much attention has been given to the neural structures that underlie the long-term consolidation of contextual memories, little is known about the mechanisms responsible for the maintenance of memory precision. Here, we demonstrate a rapid time-dependent decline in memory precision in GABAB(1a) receptor knockout mice. First, we show that GABAB(1a) receptors are required for the maintenance, but not encoding, of a precise fear memory. We then demonstrate that GABAB(1a) receptors are required for the maintenance, but not encoding, of spatial memories. Our findings suggest that GABA-mediated presynaptic inhibition regulates the maintenance of memory precision as a function of memory age.
authors.affiliation: Department of Psychology, Kent State University, Kent, Ohio 44242, USA.
authors.forename: Patrick K
authors.initials: PK
authors.lastname: Cullen
authors.forename: Brooke N
authors.initials: BN
authors.lastname: Dulka
authors.forename: Samantha
authors.initials: S
authors.lastname: Ortiz
authors.forename: David C
authors.initials: DC
authors.lastname: Riccio
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Jasnow
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003213:Conditioning, Psychological / Q000502:physiology; D004192:Discrimination, Psychological / Q000502:physiology; D005239:Fear / Q000502:physiology*; D046352:Freezing Reaction, Cataleptic / Q000502:physiology; D057567:Memory, Long-Term / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009433:Neural Inhibition / Q000502:physiology*; D009483:Neuropsychological Tests; D017729:Presynaptic Terminals / Q000502:physiology*; D018080:Receptors, GABA-B / Q000235:genetics / Q000378:metabolism*; D021641:Recognition, Psychology / Q000502:physiology; D013028:Space Perception / Q000502:physiology*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D018080:Receptors, GABA-B; D005680:gamma-Aminobutyric Acid