title: Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD.
abstract: The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated. So far, no studies have been conducted on the relationship of MMP-9 and cognitive domains in children with two phenotype models, attention deficit/hyperactivity disorder and hyperkinetic disorder (ADHD/HKD). The aim of this research was to evaluate and test the hypothesis that serum MMP-9 levels are associated with the severity of symptoms in children with ADHD/HKD and to compare the results in two models of this disorder. The study group comprised 37 Caucasian boys aged 7-12 years with HKD, being a subset of the combined ADHD subtype. Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised. The analysis of serum concentrations of MMP-9 was based on a quantitative sandwich ELISA. The statistical regression analysis revealed a correlation between increased serum MMP-9 levels and severity of symptoms in the ADHD (β = 0.33; p = 0.043) and HKD (β = 0.34, p = 0.037) model. According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain (β = 0.38; p = 0.019).
authors.affiliation: Medical University, Bialystok, Podlaskie, Poland, halina.kadziela-olech@umb.edu.pl.
authors.forename: Halina
authors.initials: H
authors.lastname: Kadziela-Olech
authors.forename: Piotr
authors.initials: P
authors.lastname: Cichocki
authors.forename: Justyna
authors.initials: J
authors.lastname: Chwiesko
authors.forename: Jerzy
authors.initials: J
authors.lastname: Konstantynowicz
authors.forename: Jan Józef
authors.initials: JJ
authors.lastname: Braszko
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood / Q000523:psychology*; D002648:Child; D006801:Humans; D007175:Impulsive Behavior; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D020780:Matrix Metalloproteinase 9