title: The Pathophysiologic Roles of TRPM7 Channel.
abstract: Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg(2+) and Ca(2+), and its channel activity is negatively regulated by free Mg(2+) and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell proliferation in several cancers, and is associated with ischemic cell death and vascular smooth muscle cell (VSMC) function. This review discusses the physiologic and pathophysiologic functions and significance of TRPM7 in several diseases.
authors.affiliation: Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan 626-870, Korea.
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Park
authors.affiliation: Department of Physiology, Seoul National University College of Medicine, Seoul 110-799, Korea.
authors.forename: Chansik
authors.initials: C
authors.lastname: Hong
authors.affiliation: Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan 626-870, Korea.
authors.forename: Byung Joo
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Department of Physiology, Seoul National University College of Medicine, Seoul 110-799, Korea.
authors.forename: Insuk
authors.initials: I
authors.lastname: So
keywords: Disease; Ion Channel; TRPM7; Transient receptor potential melastatin 7