title: Antitumor activity of phenylene bridged binuclear bis(imino-quinolyl)palladium(II) and platinum(II) complexes.
abstract: Antitumor effects of a known bis(imino-quinolyl)palladium(II) complex 1 and its newly synthesized platinum(II) analogue 2 were evaluated against human breast (MCF-7) and human colon (HT-29) cancer cell lines. The complexes gave cytotoxicity profiles that were better than the reference drug cisplatin. The highest cytotoxic activities were pronounced in complex 2 across the two examined cancer cell lines. Both compounds represent potential active drugs based on bimetallic complexes.
authors.affiliation: Chemistry Department, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa. Electronic address: wmotswainyana@uwc.ac.za.
authors.forename: William M
authors.initials: WM
authors.lastname: Motswainyana
authors.affiliation: Chemistry Department, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.
authors.forename: Martin O
authors.initials: MO
authors.lastname: Onani
authors.affiliation: Department of Biotechnology, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.
authors.forename: Abram M
authors.initials: AM
authors.lastname: Madiehe
authors.affiliation: Department of Biotechnology, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.
authors.forename: Morounke
authors.initials: M
authors.lastname: Saibu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D009942:Organometallic Compounds; D010984:Platinum; D010165:Palladium
keywords: Antitumor; Bis(imino-quinolyl); Cisplatin; Palladium(II); Platinum(II)