title: Antimicrobial efficacy of phenanthrenequinone based Schiff base complexes incorporating methionine amino acid: structural elucidation and in vitro bio assay.
abstract: This work focuses the synthesis and characterization of few novel mixed ligand Schiff base metal complexes and their biological activities. For deriving the structural aspects, spectral techniques such as FT-IR, UV-Vis., (1)H NMR, Raman, EPR and the physicochemical characterizations including elemental analysis, molar conductance and magnetic susceptibility method have been involved. All the complexes adopt square planar geometry. DNA binding ability of these complexes has been explored using diverse techniques viz. UV-Vis. absorption, fluorescence spectroscopy, viscometry and cyclic voltammetry. These studies prove that CT-DNA binding of the complexes follows the intercalation mode. Comparative DNA oxidative cleavage ability of the complexes has been done under ultraviolet photo radiation on pUC19 DNA. In addition, the biocidal action of the complexes has been investigated against few pathogenic bacteria and fungi by disc diffusion method. Importantly, the amylase inhibition activity of Cu(II) complex has been explored. The amylase inhibition property has been found to be increased upon increasing the complex concentration.
authors.affiliation: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India.
authors.forename: Thesingu Rajan
authors.initials: TR
authors.lastname: Arun
authors.affiliation: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India. Electronic address: ramchem1964@gmail.com.
authors.forename: Natarajan
authors.initials: N
authors.lastname: Raman
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000254:growth & development*; D004247:DNA / Q000737:chemistry*; D005658:Fungi / Q000254:growth & development*; D008715:Methionine / Q000737:chemistry / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D010616:Phenanthrenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: D000890:Anti-Infective Agents; D010616:Phenanthrenes; D012545:Schiff Bases; D004247:DNA; D008715:Methionine
keywords: Amylase inhibition; Antimicrobial activity; Fluorescence; Intercalation; Methionine complexes; Schiff base