title: A novel rare copy number variant of the ABCF1 gene identified among dengue fever patients from Peninsular Malaysia.
abstract: Copy number variation (CNV) is a form of genetic variation in addition to single nucleotide polymorphisms. The significance of CNV in the manifestation of a number of diseases is only recently receiving considerable attention. We genotyped 163 dengue patients from Peninsular Malaysia for genes possibly linked to dengue infection using quantitative real-time PCR. Here, we report a serendipitous discovery of a novel rare CNV of the ABCF1 gene among the dengue patients. Among these patients, two had a gain of 1 copy (CN = 3) and one had lost 1 copy (CN = 1), indicating that a rare CNV of the ABCF1 gene was detected among dengue patients from Peninsular Malaysia. Although the gene is suspected to regulate inflammatory responses and pathogen-induced cytokine storm, its relevance to dengue requires further investigation.
authors.affiliation: Institute of Medical Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, Sungai Buloh, Selangor, Malaysia hbpeng@salam.uitm.edu.my.
authors.forename: B P
authors.initials: BP
authors.lastname: Hoh
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: S S
authors.initials: SS
authors.lastname: Sam
authors.affiliation: Institute of Medical Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, Sungai Buloh, Selangor, Malaysia.
authors.forename: S H
authors.initials: SH
authors.lastname: Umi
authors.affiliation: Department of Medicine, Hospital Kota Bharu, Kelantan, Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Mahiran
authors.affiliation: Department of Paediatrics, Hospital Kota Bharu, Kelantan, Malaysia.
authors.forename: N Y
authors.initials: NY
authors.lastname: Nik Khairudin
authors.affiliation: Department of Microbiology and Parasitology, School of Medical Science, Health Campus, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
authors.forename: S
authors.initials: S
authors.lastname: Rafidah Hanim
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: S
authors.initials: S
authors.lastname: Abubakar
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D056915:DNA Copy Number Variations; D003715:Dengue / Q000235:genetics* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008296:Malaysia
chemical_list: C115776:ABCF1 protein, human; D018528:ATP-Binding Cassette Transporters