title: Medelamine C, a new omega-hydroxy alkylamine derivative from endophytic Streptomyces sp. YIM 66142.
abstract: A new alkylamine derivative and a common fatty acid were isolated from Streptomyces sp. YIM 66142. On the basis of spectral data, including HRMS, NMR and 2D NMR, their structures were determined as medelamine C (1) and isomyristic acid (2). The omega-hydroxyl group in structure 1 is rare in a natural alkylamine. The possible biosynthetic pathway in the genus Streptomyces from isomyristic acid (2) to medelamines is proposed. Compound 1 showed no obvious cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, SW480 cell lines. The omega-hydroxyl and the acetyl at NH in compound 1 decreased its cytotoxicity in comparison with that of medelamine.
authors.forename: Ju-Cheng
authors.initials: JC
authors.lastname: Zhang
authors.forename: Ya-Bin
authors.initials: YB
authors.lastname: Yang
authors.forename: Hao
authors.initials: H
authors.lastname: Zhou
authors.forename: Tian-Feng
authors.initials: TF
authors.lastname: Peng
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Yang
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Xu
authors.forename: Zhong-Tao
authors.initials: ZT
authors.lastname: Ding
mesh_terms: D004354:Drug Screening Assays, Antitumor; D060026:Endophytes / Q000737:chemistry; D005227:Fatty Acids / Q000302:isolation & purification*; D018922:HL-60 Cells; D006801:Humans; D061986:MCF-7 Cells; D019814:Myristic Acid / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D005227:Fatty Acids; C587834:medelamine C; D019814:Myristic Acid