title: Polymer monolithic capillary column fabricated by using monodisperse iron oxide nanocrystal template to enhance the electrochromatographic separation of small molecules.
abstract: Monodisperse iron oxide nanocrystals and organic solvents were utilized as coporogens in monolithic poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) capillary columns to afford stationary phases with enhanced electrochromatographic performance of small molecules. While the conventional monoliths using organic solvents only as a porogen exhibited poor resolution (Rs) <1.0 and low efficiency of 40 000-60 000 plates/m, addition of a small amount of nanocrystals to the polymerization mixture provided increased resolution (Rs > 3.0) and high efficiency ranged from 60 000 to 100 000 plates/m at the same linear velocity of 0.856 mm/s. It was considered that the mesopores introduced by the nanocrystals played an important role in the improvement of the monolith performance. This new strategy expanded the application range of the hydrophobic monoliths in the separation of polar alkaloids and narcotics. The successful applications demonstrated that the glycidyl methacrylate based monoliths prepared by using nanocrystal template are a good alternative for enhanced separation efficiency of small molecules.
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, P. R. China.
authors.forename: Zian
authors.initials: Z
authors.lastname: Lin
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Yin
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Tan
authors.forename: Ruifang
authors.initials: R
authors.lastname: Yu
authors.forename: Jiangnan
authors.initials: J
authors.lastname: Zheng
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.forename: Guonan
authors.initials: G
authors.lastname: Chen
mesh_terms: D053801:Capillary Electrochromatography / Q000295:instrumentation* / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry*; D008768:Methylmethacrylates / Q000737:chemistry*; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D009294:Narcotics / Q000302:isolation & purification; D009930:Organic Chemicals / Q000302:isolation & purification; D016062:Porosity
chemical_list: D005290:Ferric Compounds; D008768:Methylmethacrylates; D009294:Narcotics; D009930:Organic Chemicals; C000499:ferric oxide; C020347:GMA-EDMA
keywords: Capillary electrochromatography; Iron oxide nanocrystals; Polymer monolith; Small molecules