title: Prognosis value of HIF-1α expression in patients with non-small cell lung cancer.
abstract: BACKGROUND
  Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays a critical role in the development and progression of tumors. Various studies evaluating the prognostic value of HIF-1α in patients with lung cancer (LC) remain controversial. To comprehensively and quantitatively summarize the evidence on the effect of HIF-1α expression on the survival of patients with LC, a meta-analysis was carried out.
  
  
  METHODS
  Electronic databases were used to identify published studies before August 31st, 2013. Studies were assessed for quality using REMARK. Data were collected comparing overall survival in patients with high HIF-1α expression with those with low expression.
  
  
  RESULTS
  Totally, 13 papers including 1420 patients were subjected to final analysis. The combined hazard ratio (HR) was 1.60 (95% CI: 1.14-2.25, P=0.007), suggesting that high expression of HIF-1α was an indicator of poor prognosis. Further, when stratified by LC histological type (SCLC and NSCLC), study region (Asia and Europe), cut-off values (10%), tumor stage (I-III and I-IV), antibody for IHC (H1α67 and ESEE 122), and HR estimated method (univariate/multivariate analysis), most of the results were statistically significant.
  
  
  CONCLUSIONS
  Taken together, this meta-analysis revealed that HIF-1α overexpression might be a predicative factor of poor prognosis for NSCLC particularly in Asia.
authors.affiliation: Department of Respiration, First Affiliated Hospital of Bengbu Medical College, Anhui Provincial Key Laboratory of Clinical Basic Research on Respiratory Disease, Bengbu, Anhui, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Respiration, The Third People's Hospital of Bengbu City, Bengbu, Anhui, China.
authors.forename: Dan-feng
authors.initials: DF
authors.lastname: Hu
authors.affiliation: Department of Respiration, First Affiliated Hospital of Bengbu Medical College, Anhui Provincial Key Laboratory of Clinical Basic Research on Respiratory Disease, Bengbu, Anhui, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Rui
authors.affiliation: Department of Respiration, First Affiliated Hospital of Bengbu Medical College, Anhui Provincial Key Laboratory of Clinical Basic Research on Respiratory Disease, Bengbu, Anhui, China.
authors.forename: An-bang
authors.initials: AB
authors.lastname: Jiang
authors.affiliation: Department of Respiration, First Affiliated Hospital of Bengbu Medical College, Anhui Provincial Key Laboratory of Clinical Basic Research on Respiratory Disease, Bengbu, Anhui, China.
authors.forename: Zi-li
authors.initials: ZL
authors.lastname: Liu
authors.affiliation: Department of Respiration, First Affiliated Hospital of Bengbu Medical College, Anhui Provincial Key Laboratory of Clinical Basic Research on Respiratory Disease, Bengbu, Anhui, China. Electronic address: bbmchln@126.com.
authors.forename: Li-nian
authors.initials: LN
authors.lastname: Huang
mesh_terms: D000912:Antibodies, Neoplasm / Q000276:immunology; D001208:Asia / Q000453:epidemiology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000401:mortality*; D005060:Europe / Q000453:epidemiology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000401:mortality*; D011379:Prognosis; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D014157:Transcription Factors
keywords: HIF-1α; Lung cancer; Meta-analysis; Prognosis