title: Gold nanoparticles displaying tumor-associated self-antigens as a potential vaccine for cancer immunotherapy.
abstract: Golden vaccine for cancers. Gold nanoparticles enable efficient antigen delivery to dendritic cells and then activate the cells to facilitate cross-presentation, inducing antigen-specific cytotoxic T-lymphocyte responses for effective cancer therapy.
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701, South Korea.
authors.forename: Sukyung
authors.initials: S
authors.lastname: Ahn
authors.forename: In-Hyun
authors.initials: IH
authors.lastname: Lee
authors.forename: Sukmo
authors.initials: S
authors.lastname: Kang
authors.forename: Daejin
authors.initials: D
authors.lastname: Kim
authors.forename: Minsuk
authors.initials: M
authors.lastname: Choi
authors.forename: Phei Er
authors.initials: PE
authors.lastname: Saw
authors.forename: Eui-Cheol
authors.initials: EC
authors.lastname: Shin
authors.forename: Sangyong
authors.initials: S
authors.lastname: Jon
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000008:administration & dosage / Q000737:chemistry*; D019496:Cancer Vaccines / Q000276:immunology; D002460:Cell Line; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D005353:Fibronectins / Q000008:administration & dosage / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D007167:Immunotherapy; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000628:therapy; D010047:Ovalbumin / Q000737:chemistry / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D005353:Fibronectins; D007376:Interleukin-2; D006046:Gold; D007371:Interferon-gamma; D010047:Ovalbumin
keywords: cancer vaccines; extra domain B; gold nanoparticles; immunotherapy; tumor-associated antigens