title: Meningoencephalitis due to adenovirus in a healthy infant mimicking severe bacterial sepsis.
abstract: We present the case of a previously healthy 15-month-old girl with acute adenovirus infection who had features of severe bacterial sepsis and meningitis. Real-time qPCR done on cerebrospinal fluid identified adenovirus as the causative agent allowing stopping antibiotic treatment. The patient subsequently recovered without sequelae. An overview of published and unpublished data on adenovirus central nervous system infection in immunocompetent children is presented.
authors.affiliation: From the *Unidad de Enfermedades Infecciosas e Inmunopatologías Pediátrica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío; †Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla; ‡Unidad de Cuidados Intensivos Pediátrica, Hospital Universitario Virgen del Rocío, Sevilla, Spain; §Academic Unit of Clinical and Experimental Sciences; ¶Institute for Life Sciences, University of Southampton, United Kingdom; and ‖Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Joaquin
authors.initials: J
authors.lastname: Reyes-Andrade
authors.forename: Javier
authors.initials: J
authors.lastname: Sánchez-Céspedes
authors.forename: Peter
authors.initials: P
authors.lastname: Olbrich
authors.forename: Lola
authors.initials: L
authors.lastname: Falcon
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Sanchez-Ganfornina
authors.forename: Marc
authors.initials: M
authors.lastname: Tebruegge
authors.forename: Pilar
authors.initials: P
authors.lastname: Pérez-Romero
authors.forename: Olaf
authors.initials: O
authors.lastname: Neth
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000302:isolation & purification*; D000257:Adenoviridae Infections / Q000175:diagnosis* / Q000821:virology; D016470:Bacteremia / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008590:Meningoencephalitis / Q000175:diagnosis* / Q000821:virology; D060888:Real-Time Polymerase Chain Reaction