title: The impact of maternal consumption of cafeteria diet on reproductive function in the offspring.
abstract: Maternal obesity is a risk factor for the development of metabolic syndrome and childhood obesity, and early overnutrition seems to induce the development of pathologies in adulthood, including insulin resistance, cardiovascular diseases, type 2 diabetes mellitus, and a higher BMI. In addition, it is known that obesity can negatively affect fertility and reproductive function in men. The objective of this work was to investigate the impact of maternal obesity induced by the consumption of cafeteria diet on metabolic, endocrine and reproductive outcomes in the male offspring. Body weight, abdominal fat content and concentrations of insulin, leptin, glucose and total cholesterol were analyzed in dams. The same parameters were evaluated in pups when in adulthood, in addition to the analysis of sexual behavior, followed by measurement of plasma luteinizing hormone, follicle-stimulating hormone, testosterone, and prolactin. Maternal consumption of cafeteria diet affected reproductive hormone regulation in the offspring and such modifications were reflected on sexual performance. Also, these modifications were independent of time and of the reproductive period during which dams consumed the diet. Our results indicate, for the first time, that maternal nutrition may have a deep impact on the reproductive function of the adult male offspring.
authors.affiliation: Laboratory of Neuroendocrinology, Department of Physiology, Basic Health Sciences Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. Electronic address: siljacobs@yahoo.com.br.
authors.forename: Silvana
authors.initials: S
authors.lastname: Jacobs
authors.affiliation: Laboratory of Neuroendocrinology, Department of Physiology, Basic Health Sciences Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
authors.forename: Deborah S
authors.initials: DS
authors.lastname: Teixeira
authors.affiliation: Laboratory of Neuroendocrinology, Department of Physiology, Basic Health Sciences Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
authors.forename: Christiane
authors.initials: C
authors.lastname: Guilherme
authors.affiliation: Laboratory of Neuroendocrinology, Department of Physiology, Basic Health Sciences Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
authors.forename: Cláudio F K
authors.initials: CF
authors.lastname: da Rocha
authors.affiliation: Laboratory of Neuroendocrinology, Department of Physiology, Basic Health Sciences Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
authors.forename: Bruno C C
authors.initials: BC
authors.lastname: Aranda
authors.affiliation: Laboratory of Neuroendocrinology, Department of Physiology, Basic Health Sciences Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
authors.forename: Adolfo R
authors.initials: AR
authors.lastname: Reis
authors.affiliation: Laboratory of Neuroendocrinology, Department of Physiology, Basic Health Sciences Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
authors.forename: Marcelo A
authors.initials: MA
authors.lastname: de Souza
authors.affiliation: Department of Physiology, Ribeirão Preto Medical School, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Celso R
authors.initials: CR
authors.lastname: Franci
authors.affiliation: Laboratory of Neuroendocrinology, Department of Physiology, Basic Health Sciences Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
authors.forename: Gilberto L
authors.initials: GL
authors.lastname: Sanvitto
mesh_terms: D050153:Abdominal Fat; D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004032:Diet; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D009765:Obesity / Q000150:complications*; D011388:Prolactin / Q000097:blood; D017208:Rats, Wistar; D012098:Reproduction / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000502:physiology*; D013739:Testosterone / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002784:Cholesterol
keywords: Cafeteria diet; Male reproductive function; Maternal obesity; Reproductive hormones; Sexual behavior