title: Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis.
abstract: OBJECTIVE
  The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN).
  
  
  METHODS
  Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes: uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups.
  
  
  RESULTS
  On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis.
  
  
  CONCLUSIONS
  Our results suggest a possible protective effect of podocyte uPA/uPAR expression against interstitial fibrosis.
authors.affiliation: Department of Pathology, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Pathology, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Mee-Hye
authors.initials: MH
authors.lastname: Oh
authors.affiliation: Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Jae-Seok
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Gyoung-Jae
authors.initials: GJ
authors.lastname: Na
authors.affiliation: Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Hye-Wook
authors.initials: HW
authors.lastname: Gil
authors.affiliation: Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Jong-Oh
authors.initials: JO
authors.lastname: Yang
authors.affiliation: Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Sae-Yong
authors.initials: SY
authors.lastname: Hong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001284:Atrophy; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D005260:Female; D005355:Fibrosis; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000201:enzymology* / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis*; D050199:Podocytes / Q000201:enzymology* / Q000276:immunology / Q000473:pathology; D055293:Receptors, Urokinase Plasminogen Activator / Q000032:analysis*; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; C524898:PLAUR protein, human; D017395:Plasminogen Activator Inhibitor 1; D055293:Receptors, Urokinase Plasminogen Activator; C051321:SERPINE1 protein, human; D014568:Urokinase-Type Plasminogen Activator
keywords: Glomerulonephritis, IGA; Plasminogen activator inhibitor 1; Receptors, urokinase plasminogen activator; Urokinase-type plasminogen activator