title: Multifunctional Fe₃O₄@polydopamine core-shell nanocomposites for intracellular mRNA detection and imaging-guided photothermal therapy.
abstract: Multifunctional nanocomposites have the potential to integrate sensing, diagnostic, and therapeutic functions into a single nanostructure. Herein, we synthesize Fe3O4@polydopamine core-shell nanocomposites (Fe3O4@PDA NCs) through an in situ self-polymerization method. Dopamine, a melanin-like mimic of mussel adhesive proteins, can self-polymerize to form surface-adherent polydopamine (PDA) films onto a wide range of materials including Fe3O4 nanoparticles used here. In such nanocomposites, PDA provides a number of advantages, such as near-infrared absorption, high fluorescence quenching efficiency, and a surface for further functionalization with biomolecules. We demonstrate the ability of the Fe3O4@PDA NCs to act as theranostic agents for intracellular mRNA detection and multimodal imaging-guided photothermal therapy. This work would stimulate interest in the use of PDA as a useful material to construct multifunctional nanocomposites for biomedical applications.
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry, Fuzhou University , Fuzhou 350108, China.
authors.forename: Li-Sen
authors.initials: LS
authors.lastname: Lin
authors.forename: Zhong-Xiao
authors.initials: ZX
authors.lastname: Cong
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Cao
authors.forename: Kai-Mei
authors.initials: KM
authors.lastname: Ke
authors.forename: Qiao-Li
authors.initials: QL
authors.lastname: Peng
authors.forename: Jinhao
authors.initials: J
authors.lastname: Gao
authors.forename: Huang-Hao
authors.initials: HH
authors.lastname: Yang
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
mesh_terms: D006801:Humans; D007211:Indoles / Q000737:chemistry*; D042541:Intracellular Space / Q000378:metabolism*; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use*; D053758:Nanoparticles / Q000737:chemistry*; D061088:Photoacoustic Techniques; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D013499:Surface Properties; D013696:Temperature
chemical_list: D007211:Indoles; D011108:Polymers; D012333:RNA, Messenger; C568283:polydopamine