title: Is abnormal glucose metabolism during pregnancy related to endothelial dysfunction?
abstract: OBJECTIVE
  Endothelial dysfunction is an independent risk factor for cardiovascular events. We aimed to investigate the relationship between endothelial dysfunction and gestational diabetes mellitus and impaired glucose tolerance.
  
  
  METHODS
  Pregnant women who had impaired glucose metabolism in the 75-g oral glucose tolerance test (OGTT) and their age- and body mass index-matched controls were included in the study and assessed for flow-mediated vasodilatation to evaluate endothelial dysfunction.
  
  
  RESULTS
  A total of 51 patients participated in the study. There were 20 patients in the control group, 13 in the impaired glucose tolerance group and 18 in the gestational diabetes mellitus group. Flow-mediated vasodilatation measured at the 60th and 120th seconds were significantly lower in the impaired glucose tolerance and gestational diabetes mellitus groups than in the control group (8.5 ± 5.7 and 8.9 ± 6.5 versus 14.9 ± 9.0, p=0.022 and 6.2 ± 6.7 and 5.2 ± 5.0 versus 12.0 ± 8.3, p=0.011, respectively).
  
  
  CONCLUSIONS
  Patients with gestational diabetes mellitus and impaired glucose tolerance have impaired endothelial dysfunction. Delivery might have protective effects on endothelial functions. The significance of impaired endothelial dysfunction for pregnant women must be investigated, and if needed, lifestyle changes might be suggested, according to the determined importance of the endothelial dysfunction.
authors.affiliation: Canakkale Government Hospital, Cardiology Clinic , Canakkale , Turkey .
authors.forename: Omer
authors.initials: O
authors.lastname: Gungor
authors.forename: Emine
authors.initials: E
authors.lastname: Gazi
authors.forename: Gulay
authors.initials: G
authors.lastname: Ozkececi
authors.forename: Ayse Nur
authors.initials: AN
authors.lastname: Cakir Gungor
authors.forename: Sibel
authors.initials: S
authors.lastname: Cevizci
authors.forename: Servet
authors.initials: S
authors.lastname: Hacivelioglu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Temiz
authors.forename: Nadire
authors.initials: N
authors.lastname: Mert
authors.forename: Gulengul
authors.initials: G
authors.lastname: Koken
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D018149:Glucose Intolerance / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D005951:Glucose Tolerance Test; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose
keywords: Endothelial dysfunction; gestational diabetes; pregnancy