title: New dinucleoside phosphonate derivatives as prodrugs of 3'-azido-3'-deoxythymidine and β-L-2',3'-dideoxy-3'-thiacytidine: synthesis and anti-HIV properties.
abstract: [Formula: see text]New phosphonate homodimers of 3'-azido-3'-deoxythymidine (AZT) and a phosphonate heterodimer of β-L-2',3'-dideoxy-3'-thiacytidine (3TC) and AZT were synthesized. The compounds demonstrated moderate anti-HIV activity. Stability of the compounds in human blood serum was studied. A correlation between anti-HIV activity and stability was defined.
authors.affiliation: a Engelhardt Institute of Molecular Biology RAS , Moscow , Russia.
authors.forename: Pavel N
authors.initials: PN
authors.lastname: Solyev
authors.forename: Maxim V
authors.initials: MV
authors.lastname: Jasko
authors.forename: Inna L
authors.initials: IL
authors.lastname: Karpenko
authors.forename: Yury A
authors.initials: YA
authors.lastname: Sharkin
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Shipitsyn
authors.forename: Marina K
authors.initials: MK
authors.lastname: Kukhanova
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002460:Cell Line; D004355:Drug Stability; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006868:Hydrolysis; D019259:Lamivudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D011355:Prodrugs; D019259:Lamivudine; D015215:Zidovudine