title: Acaricidal activity of 9-oxo-10,11-dehydroageraphorone extracted from Eupatorium adenophorum in vitro.
abstract: The acaricidal activity of the 9-oxo-10,11-dehydroageraphorone (euptox A), a cadenine sesquiterpene from Eupatorium adenophorum (E. adenophorum) against Sarcoptes scabiei and Psoroptes cuniculi was tested in vitro. A complementary log-log (CLL) model was used to analyze the data of the toxicity tests in vitro. The results showed euptox A had strong toxicity against mites, killing all S. scabiei at 3 and 4 mg/ml (m/v) concentration, while 4 mg/ml euptox A was also found to kill all P. cuniculi within a 4 h period. Similarly, 2, 3 and 4 mg/ml concentration of euptox A had strong toxicity against S. scabiei, with median lethal time (LT50) values at 0.687, 0.526, 0.326 h, respectively. 3 mg/ml and 4 mg/ml showed strong acaricidal action against P. cuniculi; the LT50 values were 0.693 and 0.493 h, respectively. The median lethal concentration (LC50) values were 1.068 mg/ml for Scabies mite and 0.902 mg/ml for P. cuniculi in 2 h. The results indicate that euptox A has strong acaricidal activity and may exploit as novel drugs for the effective control of animal acariasis.
authors.affiliation: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Liao
authors.affiliation: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China. Electronic address: yanchunhu@126.com.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Tan
authors.affiliation: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Mo
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China, School of Life Science, Northwest University, Xi'an 710069, China.
authors.forename: Yahui
authors.initials: Y
authors.lastname: Wei
mesh_terms: D056810:Acaricides / Q000302:isolation & purification / Q000633:toxicity; D036603:Ageratina / Q000737:chemistry*; D000818:Animals; D007928:Lethal Dose 50; D008924:Mite Infestations / Q000188:drug therapy / Q000469:parasitology; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity; D040042:Psoroptidae; D011817:Rabbits; D012520:Sarcoptes scabiei; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000633:toxicity
chemical_list: C098165:9-oxo-10,11-dehydroagerophorone; D056810:Acaricides; D010936:Plant Extracts; D012717:Sesquiterpenes
keywords: 9-Oxo-10,11-dehydroageraphorone; Acaricidal activity; Psoroptes cuniculi; Sarcoptes scabiei