title: A greater number of euploid blastocysts in a given cohort predicts  excellent outcomes in single embryo transfer cycles.
abstract: OBJECTIVE
  This multicentered retrospective study analyzed whether the quantity of euploid blastocysts in a given cohort after comprehensive chromosomal screening can be used to identify candidates for single embryo transfer.
  
  
  METHODS
  Blastocysts from 437 patients underwent trophectoderm biopsy followed by array comparative genomic hybridization. Embryos were then selected for single or double embryo transfer. The number of euploid blastocysts produced and transferred for each patient was recorded, as was clinical pregnancy rate and multiple gestation rate.
  
  
  RESULTS
  In patients with ≤ 3 euploid blastocysts, clinical pregnancy rate was higher in double, compared to single embryo transfers. However, in patients with ≥ 4 euploid blastocysts, clinical pregnancy rate was not reduced with single embryo transfer was performed, whereas the multiple gestation rate was greatly reduced.
  
  
  CONCLUSIONS
  Size of the euploid embryo cohort is a marker for success in single embryo transfer cycles. Patients who produce at least four euploid blastocysts are outstanding candidates for single embryo transer.
authors.forename: Scott
authors.initials: S
authors.lastname: Morin
authors.forename: Katherine
authors.initials: K
authors.lastname: Melzer-Ross
authors.forename: David
authors.initials: D
authors.lastname: McCulloh
authors.forename: Jamie
authors.initials: J
authors.lastname: Grifo
authors.forename: Santiago
authors.initials: S
authors.lastname: Munné
mesh_terms: D000328:Adult; D001755:Blastocyst / Q000166:cytology / Q000378:metabolism; D055028:Comparative Genomic Hybridization; D015925:Cryopreservation / Q000379:methods*; D010064:Embryo Implantation / Q000502:physiology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted; D056826:Single Embryo Transfer