title: Tracheal ulcer due to Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly.
abstract: A 74-year-old man was referred to our hospital because of a tracheal stenosis circumscribed with soft tissue density and a left pulmonary nodule. Open biopsy of a right submandibular lymph node revealed diffuse large B-cell lymphoma, and the malignant cells were positive for Epstein-Barr virus gene products. Bronchofiberscopy revealed a tracheal necrotizing ulcer. After chemotherapy, the tracheal ulcer resolved. To our knowledge, this is the first report of a case of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly with a tracheal ulcer.
authors.affiliation: Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Japan; Department of Respiratory Medicine, Kuroki Memorial Hospital, Japan. Electronic address: tak@oita-u.ac.jp.
authors.forename: Takeo
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Japan. Electronic address: okotas96@oita-u.ac.jp.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Fujisaki
authors.affiliation: Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Japan. Electronic address: s-nishio@oita-u.ac.jp.
authors.forename: Suehiro
authors.initials: S
authors.lastname: Nishio
authors.affiliation: Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Japan. Electronic address: hiroshige1227@gmail.com.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Hiroshige
authors.affiliation: Center for Community Medicine, Oita University Faculty of Medicine, Japan. Electronic address: eishida@oita-u.ac.jp.
authors.forename: Eishi
authors.initials: E
authors.lastname: Miyazaki
authors.affiliation: Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Japan. Electronic address: kadota@oita-u.ac.jp.
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kadota
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D001999:Bronchoscopy; D005336:Fiber Optic Technology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D008297:Male; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D014133:Tracheal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014134:Tracheal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D014456:Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
keywords: Bronchofiberscopy; Elderly; Epstein-Barr virus; Lymphoma; Tracheal ulcer