title: Molecular recognition of curcumin (Indian Ayurvedic medicine) by the supramolecular probe, p-t-butyl calix(8)arene.
abstract: The thermodynamic property of the host-guest complexes formed between the curcumin, component of Indian Ayurvedic medicine turmeric, a drug molecule, with the supra molecule, p-t-butyl calix(8)arene was studied. p-t-Butyl calix(8)arene has been used as a host molecule and curcumin as a guest molecule. Optical absorption spectral studies were carried out to investigate the molecular recognition properties of p-t-butyl calix(8)arene with curcumin. The stochiometry of the host-guest complexes formed and the binding constant were determined. An interesting 1:1 and 4:1 stochiometric host-guest complexes were formed. Job's continuous method of variation and Benesi-Hildebrand expression were used for the determination of binding constant and the stochiometry of the host-guest complex formed.
authors.affiliation: Department of Chemistry, Shri Meenakshi Government College for Women (Autonomous), Madurai 625 002, India.
authors.forename: C
authors.initials: C
authors.lastname: Meenakshi
authors.affiliation: Department of Laser Studies, School of Physics, Madurai Kamaraj University, Madurai 625 021, India.
authors.forename: P
authors.initials: P
authors.lastname: Jayabal
authors.affiliation: Department of Laser Studies, School of Physics, Madurai Kamaraj University, Madurai 625 021, India. Electronic address: vr.optics1@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Ramakrishnan
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D047250:Calixarenes / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry*; D008515:Medicine, Ayurvedic
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D047250:Calixarenes; D003474:Curcumin
keywords: Component of Indian Ayurvedic medicine; Curcumin; Drug molecule; Molecular recognition; P-t-butyl calix(8)arene