title: Experimental study on the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells.
abstract: BACKGROUND
  [corrected] Cantharidin, and its derivatives can not only inhibit the proliferation of tumor cells, but can also induce tumor cell apoptosis. It shows cantharidin exhibits a wide range of reactivity in anticancer. The objective of this paper was to study the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells.
  
  
  METHODS
  MTT assay was used to detect the proliferation of HepG2 cells, and immunohisto-chemical method was used to detect the change in VEGF, protein level, and to determine the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells.
  
  
  RESULTS
  As results, sodium cantharidinate significantly inhibited the growth of HepG2 cells in a time-and dose-dependent manner.
  
  
  CONCLUSIONS
  We conclude that sodium cantharidinate has an inhibitory effect on human hepatoma HepG2 cells.
authors.affiliation: Department of Vascular, Gansu Provincial Hospital, Lanzhou 730000, China.
authors.forename: Shi-Qi
authors.initials: SQ
authors.lastname: Wen
authors.affiliation: Department of Vascular, Gansu Provincial Hospital, Lanzhou 730000, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Vascular, Gansu Provincial Hospital, Lanzhou 730000, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Hu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis; D002193:Cantharidin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D049109:Cell Proliferation; D001517:Coleoptera / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D012964:Sodium
chemical_list: D000970:Antineoplastic Agents; D012964:Sodium; D002193:Cantharidin
keywords: MTT assay; human hepatoma HepG2; sodium cantharidinate