title: How do we use molecular red blood cell antigen typing to supplement pretransfusion testing?
abstract: The molecular basis of many blood group antigens is known, and it provides a means for predicting the red blood cell phenotype. Molecular typing methods are useful when serologic typing cannot be performed, due to sample or reagent limitations. We discuss the implementation of a commercial molecular typing assay at our Transfusion Service, the indications for testing, and the advantages and drawbacks of the assay. We also present our algorithm for selecting candidates for testing.
authors.affiliation: Section of Transfusion Medicine, Department of Clinical Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Suneeti
authors.initials: S
authors.lastname: Sapatnekar
authors.forename: Priscilla I
authors.initials: PI
authors.lastname: Figueroa
mesh_terms: D000465:Algorithms; D000755:Anemia, Sickle Cell / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001789:Blood Group Antigens / Q000032:analysis*; D001803:Blood Transfusion / Q000379:methods*; D006801:Humans; D058889:Molecular Typing / Q000379:methods*
chemical_list: D001323:Autoantibodies; D001789:Blood Group Antigens