title: Cytological and biochemical biomarkers in adult female perch (Perca fluviatilis) in a chronically polluted gradient in the Stockholm recipient (Sweden).
abstract: By measuring a battery of cytological and biochemical biomarkers in adult female perch (Perca fluviatilis), the city of Stockholm (Sweden) was investigated as a point source of anthropogenic aquatic pollution. The investigation included both an upstream gradient, 46 km westwards through Lake Mälaren, and a downstream gradient, 84 km eastwards through the Stockholm archipelago. Indeed, there was a graded response for most of the biomarkers and for the muscle concentrations of ΣPBDE, four organotin compounds and PFOS in the perch. The results indicated severe pollution in central Stockholm, with poor health of the perch, characterised by increased frequency of micronucleated erythrocytes, altered liver apoptosis, increased liver catalase activity, decreased brain aromatase activity, and decreased liver lysosomal membrane stability. Some biomarker responses were lowest in the middle archipelago and increased again eastwards, indicating a second, partly overlapping, gradient of toxic effects from the Baltic Sea.
authors.affiliation: Department of Applied Environmental Science (ITM), Stockholm University, SE-10691 Stockholm, Sweden. Electronic address: tomas.hansson@itm.su.se.
authors.forename: Tomas
authors.initials: T
authors.lastname: Hansson
authors.affiliation: Nature Research Centre, Akademijos 2, LT-08412 Vilnius, Lithuania.
authors.forename: Janina
authors.initials: J
authors.lastname: Baršienė
authors.affiliation: Department of Applied Environmental Science (ITM), Stockholm University, SE-10691 Stockholm, Sweden.
authors.forename: Ulla
authors.initials: U
authors.lastname: Tjärnlund
authors.affiliation: Department of Applied Environmental Science (ITM), Stockholm University, SE-10691 Stockholm, Sweden.
authors.forename: Gun
authors.initials: G
authors.lastname: Åkerman
authors.affiliation: Department of Applied Environmental Science (ITM), Stockholm University, SE-10691 Stockholm, Sweden; Swedish Environmental Protection Agency, SE-10648 Stockholm, Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Linderoth
authors.affiliation: Department of Applied Environmental Science (ITM), Stockholm University, SE-10691 Stockholm, Sweden.
authors.forename: Yngve
authors.initials: Y
authors.lastname: Zebühr
authors.affiliation: WSP Environmental, Arenavägen 7, SE-12188 Stockholm, Sweden.
authors.forename: John
authors.initials: J
authors.lastname: Sternbeck
authors.affiliation: Department of Applied Environmental Science (ITM), Stockholm University, SE-10691 Stockholm, Sweden; Bengt Dahlgren Stockholm AB, Sickla Industriväg 6, SE-13134 Nacka, Sweden.
authors.forename: Ulf
authors.initials: U
authors.lastname: Järnberg
authors.affiliation: Department of Applied Environmental Science (ITM), Stockholm University, SE-10691 Stockholm, Sweden.
authors.forename: Lennart
authors.initials: L
authors.lastname: Balk
mesh_terms: D000818:Animals; D001141:Aromatase; D015415:Biomarkers / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D005618:Fresh Water / Q000737:chemistry; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D005980:Glutathione Reductase / Q000235:genetics / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D009947:Organotin Compounds; D010471:Perches / Q000378:metabolism*; D013548:Sweden; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D009947:Organotin Compounds; D014874:Water Pollutants, Chemical; D005954:Glucosephosphate Dehydrogenase; D001141:Aromatase; D005980:Glutathione Reductase
keywords: Apoptosis; Aromatase; Catalase; Glucose-6-phosphate dehydrogenase; Lysosomal membrane stability; Micronucleated erythrocytes