title: Serum amyloid-A in Behçet's disease.
abstract: Serum amyloid-A (SAA) is an acute phase protein, synthesized by the liver and previously investigated as a marker of disease activity in many rheumatologic disorders. Its significance in Behçet’s disease (BD), a chronic inflammatory disorder at the crossroad between autoimmune and autoinflammatory syndromes, is still unraveled. Our aim was to assess the role of SAA levels as a potential marker of disease activity in patients with BD. According to our findings, the occurrence of oral aphthosis, neurological impairment, and ocular disease is significantly associated with SAA serum levels higher than 30, 50, and 150 mg/L, respectively. We also suggest that increased SAA levels might identify a thrombotic risk in BD with previous or concurrent vascular involvement.
authors.affiliation: Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Siena, Italy. cantariniluca@hotmail.com
authors.forename: Antonio
authors.initials: A
authors.lastname: Vitale
authors.forename: Donato
authors.initials: D
authors.lastname: Rigante
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lopalco
authors.forename: Maria Giuseppina
authors.initials: MG
authors.lastname: Brizi
authors.forename: Francesco
authors.initials: F
authors.lastname: Caso
authors.forename: Rossella
authors.initials: R
authors.lastname: Franceschini
authors.forename: Rosario
authors.initials: R
authors.lastname: Denaro
authors.forename: Mauro
authors.initials: M
authors.lastname: Galeazzi
authors.forename: Leonardo
authors.initials: L
authors.lastname: Punzi
authors.forename: Florenzo
authors.initials: F
authors.lastname: Iannone
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lapadula
authors.forename: Antonella
authors.initials: A
authors.lastname: Simpatico
authors.forename: Edoardo
authors.initials: E
authors.lastname: Marrani
authors.forename: Luisa
authors.initials: L
authors.lastname: Costa
authors.forename: Rolando
authors.initials: R
authors.lastname: Cimaz
authors.forename: Luca
authors.initials: L
authors.lastname: Cantarini
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000685:Serum Amyloid A Protein / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D000685:Serum Amyloid A Protein