title: Simultaneous determination and pharmacokinetic comparisons of multi-ingredients after oral administration of radix salviae miltiorrhizae extract, hawthorn extract, and a combination of both extracts to rats.
abstract: A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration of Radix Salviae Miltiorrhizae extract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats.
authors.affiliation: School of Medicine, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China.
authors.forename: Yu-Qiang
authors.initials: YQ
authors.lastname: Liu
authors.affiliation: School of Medicine, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Cai
authors.affiliation: School of Medicine, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.affiliation: School of Medicine, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China.
authors.forename: Feng-Wei
authors.initials: FW
authors.lastname: Bao
authors.affiliation: School of Medicine, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China.
authors.forename: Zhen-Qiu
authors.initials: ZQ
authors.lastname: Zhang