title: Landiolol hydrochloride for prevention of atrial fibrillation after cardiac surgery: a meta-analysis.
abstract: BACKGROUND
  Atrial fibrillation (AF) is the most common arrhythmic complication after cardiac surgery. Several studies have compared the efficacy of landiolol and placebo or other agents in preventing new-onset AF in patients after cardiac surgery. In this study, we conducted a meta-analysis to determine whether landiolol is effective in preventing new-onset AF after cardiac surgery.
  
  
  RESULTS
  Five randomized controlled trials and two retrospective analyses were included in this study. The clinical outcomes of interest were the occurrence of AF after cardiac surgery and major complications. Meta-analysis was performed using RevMan 5.0.18 software, and pooled estimates of the effect were reported as risk ratios (RR) with 95% confidence intervals (CI). The results of this meta-analysis indicate that landiolol is significantly associated with a decreased risk of occurrence of AF after cardiac surgery (RR = 0.33; 95% CI: 0.23-0.48; P < 0.00001) and is not associated with an increased risk of major complications (RR = 0.79; 95% CI: 0.43-1.45; P = 0.45) compared with the control group.
  
  
  CONCLUSIONS
  Landiolol administration in the perioperative period can reduce the occurrence of AF after cardiac surgery without increasing the risk of major complications. It can be used to prevent new-onset AF safely after cardiac surgery.
authors.affiliation: Department of Cardiology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
authors.forename: Shanxin
authors.initials: S
authors.lastname: Liu
authors.forename: Chang
authors.initials: C
authors.lastname: Bian
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Jian
authors.forename: Wenmin
authors.initials: W
authors.lastname: Liu
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage; D001281:Atrial Fibrillation / Q000401:mortality* / Q000517:prevention & control*; D006348:Cardiac Surgical Procedures / Q000401:mortality*; D006801:Humans; D015994:Incidence; D009025:Morpholines / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000401:mortality* / Q000517:prevention & control*; D011292:Premedication / Q000379:methods*; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D014508:Urea / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000889:Anti-Arrhythmia Agents; D009025:Morpholines; C077049:landiolol; D014508:Urea
keywords: atrial fibrillation; cardiac surgery; landiolol hydrochloride; β1-selective blocker