title: Bemiparin, an effective and safe low molecular weight heparin: a review.
abstract: Bemiparin is a low molecular weight heparin (LMWH) indicated for the acute treatment of deep vein thrombosis with or without pulmonary embolism, for the prophylaxis of venous thromboembolism in surgical and non-surgical patients and for the prevention of clotting in the extracorporeal circuit during hemodialysis. Due to its excellent pharmacological profile-the second-generation LMWH with the lowest molecular weight, the longest half-life and the highest anti-Factor Xa/anti-Factor IIa activity ratio-it can be safely used in special categories of patients (children, elderly, patients with renal impairment and congestive heart failure). Several studies demonstrated its safety and efficacy, while cost analyses show the economic benefits of bemiparin treatment as compared to other heparins. Recent evidences suggested the application of bemiparin even in the management of diabetic foot ulcers. The aim of this narrative review was to evaluate literature according to results coming from studies involving bemiparin administration in various clinical conditions.
authors.affiliation: Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy. Electronic address: marcomatteo.ciccone@uniba.it.
authors.forename: Marco Matteo
authors.initials: MM
authors.lastname: Ciccone
authors.affiliation: Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Cortese
authors.affiliation: Department of Pharmacy-Pharmaceutical Sciences, University of Bari, Bari, Italy.
authors.forename: Filomena
authors.initials: F
authors.lastname: Corbo
authors.affiliation: Cirurgia vascular y flebologia, cirurgia general y laparoscopica, Guatemala.
authors.forename: Noel Ernesto
authors.initials: NE
authors.lastname: Corrales
authors.affiliation: College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Abdul Kareem
authors.initials: AK
authors.lastname: Al-Momen
authors.affiliation: Ochsner Clinic LLC-Cardiology Department, Slidell, LA, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: Silva
authors.affiliation: Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy.
authors.forename: Annapaola
authors.initials: A
authors.lastname: Zito
authors.affiliation: Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Pinto
authors.affiliation: Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Gesualdo
authors.affiliation: Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Scicchitano
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects / Q000191:economics / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects / Q000191:economics / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D011655:Pulmonary Embolism / Q000097:blood / Q000150:complications / Q000517:prevention & control*; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000097:blood / Q000150:complications / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; C411345:bemiparin
keywords: Acenocoumarol (PubChem CID: 54676537); Bemiparin; Bemiparin (PubChem CID: 25244225); Dabigatran (PubChem CID: 216210); Enoxaparin (PubChem CID: 772); Fondaparinux (PubChem CID: 5282448); Heparin (PubChem CID: 444410); Idraparinux (PubChem CID: 3083445); Low molecular weight heparin; Prevention; Rivaroxaban (PubChem CID: 9875401); Venous thromboembolism; Warfarin (PubChem CID: 54678486)