title: Swallowing outcomes following unilateral STN vs. GPi surgery: a retrospective analysis.
abstract: The adverse effects of deep brain stimulation (DBS) surgery on swallowing could potentially exacerbate the natural deterioration of airway protection associated with Parkinson's disease (PD) degeneration and increase the incidence of aspiration pneumonia and associated death. There are no studies that compare swallowing outcomes associated with subthalamic nucleus (STN) versus globus pallidus interna (GPi) DBS surgery; therefore, we completed a retrospective study comparing swallowing outcomes in a cohort of patients with PD who underwent unilateral DBS surgery in either the STN or GPi. A chart review was completed to identify all patients with a diagnosis of PD who received videofluoroscopic swallowing evaluations before DBS and after unilateral DBS in the STN or GPi. The retrospective search yielded 33 patients (STN = 14, GPi = 19) with idiopathic PD who met the inclusion criteria. Mean penetration-aspiration (PA) scores did not change significantly for participants who underwent GPi surgery (z = -.181, p = .857), but mean PA scores significantly worsened for participants who underwent STN DBS (z = -2.682, p = .007). There was a significant improvement in Unified PD Rating Scale (UPDRS) scores off medication before surgery, to off medication and on stimulation after surgery for both groups (F = 23.667, p < .001). Despite the limitations of a retrospective analysis, this preliminary study suggests that unilateral STN DBS may have an adverse effect on swallowing function, while unilateral GPi DBS does not appear to have a similar deleterious effect. This study and other future studies should help to elucidate the mechanisms underpinning the effects of DBS on swallowing function.
authors.affiliation: Department of Speech, Language, and Hearing Sciences, University of Florida, PO Box 117420, Gainesville, FL, 32611, USA, michi81@ufl.edu.
authors.forename: Michelle S
authors.initials: MS
authors.lastname: Troche
authors.forename: Alexandra E
authors.initials: AE
authors.lastname: Brandimore
authors.forename: Kelly D
authors.initials: KD
authors.lastname: Foote
authors.forename: Takashi
authors.initials: T
authors.lastname: Morishita
authors.forename: Dennis
authors.initials: D
authors.lastname: Chen
authors.forename: Karen W
authors.initials: KW
authors.lastname: Hegland
authors.forename: Michael S
authors.initials: MS
authors.lastname: Okun
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation / Q000379:methods*; D003679:Deglutition / Q000502:physiology*; D005260:Female; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods*; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D012189:Retrospective Studies; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000601:surgery*; D016896:Treatment Outcome