title: Assessment of efficacy of platelet-rich plasma (PRP) on infraorbital dark circles and crow's feet wrinkles.
abstract: BACKGROUND
  Infraorbital skin hyperpigmentation, commonly called dark circles, and crow's feet wrinkles are common cosmetic concerns. Various methods of treatment have been evaluated with variable outcomes.
  
  
  OBJECTIVE
  This study was performed to assess the efficacy of platelet-rich plasma (PRP) injection for treating periorbital dark circles and crow's feet.
  
  
  METHODS
  Ten participants with a mean age of 41.2 years were treated in a single session with intradermal injections of 1.5 mL PRP into tear trough area and crow's feet wrinkles on each side. The effects on melanin content, color homogeneity of the treated area, epidermal stratum corneum hydration, and wrinkle volume and visibility index were compared 3 months after treatment with baseline. Physician's global assessment and participants' satisfaction and any potential side effects were also assessed.
  
  
  RESULTS
  The improvement in infraorbital color homogeneity was statistically significant (P = 0.010), but no statistically significant changes were observed in melanin content, stratum corneum hydration, wrinkle volume, and visibility index. Participant's satisfaction score and physician's global assessment score were 2.2 and 1.7, respectively, on a 0-3 scale.
  
  
  CONCLUSIONS
  Platelet-rich plasma may have the potential to improve infraorbital dark circle in terms of color homogeneity of the region, though this remains to be proven using larger, controlled studies using multiple injections.
authors.affiliation: Center for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Pedram
authors.initials: P
authors.lastname: Mehryan
authors.forename: Hamed
authors.initials: H
authors.lastname: Zartab
authors.forename: Ali
authors.initials: A
authors.lastname: Rajabi
authors.forename: Neda
authors.initials: N
authors.lastname: Pazhoohi
authors.forename: Alireza
authors.initials: A
authors.lastname: Firooz
mesh_terms: D000328:Adult; D003879:Dermatologic Agents; D004954:Esthetics; D005143:Eyelids; D006801:Humans; D007271:Injections, Intradermal; D008875:Middle Aged; D017060:Patient Satisfaction; D053657:Platelet-Rich Plasma; D015595:Skin Aging; D012880:Skin Pigmentation / Q000187:drug effects
chemical_list: D003879:Dermatologic Agents
keywords: crow's feet; melanin; platelet-rich plasma; trial; wrinkles