title: Spectral-domain optical coherence tomography evaluation of choroidal melanoma and nevus fine-needle aspiration biopsy incision sites.
abstract: The authors present three cases in which spectral-domain optical coherence tomography was used to identify fine-needle aspiration biopsy incision sites. These biopsies were performed to obtain tissue for gene expression profiling of choroidal tumors. A transvitreal route into the apex of the tumors was utilized for the biopsies while the patients underwent pars plana vitrectomy, membrane peel, laser ablation, phacoemulsification with posterior chamber intraocular lens implantation, and intravitreal triamcinolone acetonide. To the best of the authors' knowledge, this is the first report documenting fine-needle aspiration biopsy incision wound architecture of the posterior segment with optical coherence tomography.
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Murray
authors.forename: Aaron S
authors.initials: AS
authors.lastname: Gold
authors.forename: Arnold M
authors.initials: AM
authors.lastname: Markoe
authors.forename: Andrea
authors.initials: A
authors.lastname: Wildner
authors.forename: Azeema
authors.initials: A
authors.lastname: Latiff
authors.forename: Ernesto
authors.initials: E
authors.lastname: Bermudez
authors.forename: Fiona
authors.initials: F
authors.lastname: Ehlies
mesh_terms: D000368:Aged; D044963:Biopsy, Fine-Needle / Q000379:methods; D002830:Choroid Neoplasms / Q000235:genetics / Q000473:pathology*; D020869:Gene Expression Profiling; D052138:Genes, Neoplasm; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000235:genetics / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*