title: Vitamin D status and its relationship with body composition, bone mineral density and fracture risk in urban central south Chinese postmenopausal women.
abstract: OBJECTIVE
  This study was designed to assess vitamin D (25(OH)D) status and its relationship with bone mineral density (BMD) and fracture risk, which was determined using the FRAX algorithm, among postmenopausal central south Chinese women, and to identify the risk factors for vitamin D deficiency and osteoporosis.
  
  
  METHODS
  This cross-sectional study involved 578 healthy postmenopausal central south Chinese women. Fat mass and BMD at lumbar spine (L1-L4), femur neck and total hip were measured with dual X-ray absorptiometry. Serum levels of 25(OH)D, parathyroid hormone and creatinine were measured. The 10-year probabilities of hip and major osteoporotic fracture were calculated by the FRAX model.
  
  
  RESULTS
  Approximately 72.1% women were vitamin D deficient (25(OH)D <50 nmol/l). Serum 25(OH)D levels did not correlate with body mass index (BMI), fat mass and weight. They positively correlated with all BMDs (p < 0.05) and negatively correlated with both 10-year fracture probabilities (p < 0.05). BMI ≤19 and age ≥65 years were risk factors for osteoporosis at all sites.
  
  
  CONCLUSIONS
  Vitamin D deficiency was prevalent among postmenopausal central south Chinese women. Serum 25(OH)D levels were correlated with all BMDs and negatively correlated with both 10-year fracture probabilities.
authors.affiliation: Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, PR China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.forename: Yangna
authors.initials: Y
authors.lastname: Ou
authors.forename: Hongbing
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Zhang
authors.forename: Houde
authors.initials: H
authors.lastname: Zhou
authors.forename: Lihong
authors.initials: L
authors.lastname: Liu
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Sheng
authors.forename: Eryuan
authors.initials: E
authors.lastname: Liao
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D044466:Asian People; D001823:Body Composition; D015992:Body Mass Index; D015519:Bone Density; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging; D006620:Hip Fractures / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008875:Middle Aged; D009752:Nutritional Status; D010281:Parathyroid Hormone / Q000097:blood; D017698:Postmenopause / Q000097:blood*; D015995:Prevalence; D012307:Risk Factors; D014807:Vitamin D / Q000008:administration & dosage / Q000097:blood*; D014808:Vitamin D Deficiency / Q000453:epidemiology*
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D