title: Cross sectional study to evaluate the effect of duration of type 2 diabetes mellitus on the nerve conduction velocity in diabetic peripheral neuropathy.
abstract: OBJECTIVE
  To study the nerve conduction velocity in clinically undetectable and detectable peripheral neuropathy in type 2 diabetes mellitus with variable duration.
  
  
  METHODS
  This cross sectional study was conducted in diagnosed type 2 diabetes mellitus patients. They were divided in groups: Group I (n=37) with clinically detectable diabetic peripheral neuropathy of shorter duration and Group II (n=27) with clinically detectable diabetic peripheral neuropathy of longer duration. They were compared with T2DM patients (n=22) without clinical neuropathy. Clinical diagnosis was based on neuropathy symptom score (NSS) and neuropathy disability score (NDS) for signs. Nerve conduction velocity was measured in both upper and lower limbs. Median, ulnar, common peroneal and posterior tibial nerves were selected for motor nerve conduction study and median and sural nerves were selected for sensory nerve conduction study.
  
  
  RESULTS
  The comparisons were done between nerve conduction velocities of motor and sensory nerves in patients of clinically detectable neuropathy and patients without neuropathy in type 2 diabetes mellitus population. This study showed significant electrophysiological changes with duration of disease. Nerve conduction velocities in lower limbs were significantly reduced even in patients of shorter duration with normal upper limb nerve conduction velocities.
  
  
  CONCLUSIONS
  Diabetic neuropathy symptom score (NSS) and neuropathy disability score (NDS) can help in evaluation of diabetic sensorimotor polyneuropathy though nerve conduction study is more powerful test and can help in diagnosing cases of neuropathy.
authors.affiliation: Department of Physiology, J. N. Medical College Hospital, Aligarh Muslim University, Aligarh 202002, India.
authors.forename: Gauhar
authors.initials: G
authors.lastname: Hussain
authors.affiliation: Department of Physiology, J. N. Medical College Hospital, Aligarh Muslim University, Aligarh 202002, India.
authors.forename: S Aijaz Abbas
authors.initials: SA
authors.lastname: Rizvi
authors.affiliation: Department of Physiology, J. N. Medical College Hospital, Aligarh Muslim University, Aligarh 202002, India.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Singhal
authors.affiliation: Rajiv Gandhi Centre for Diabetes and Endocrinology, J. N. Medical College Hospital, Aligarh Muslim University, Aligarh 202002, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Zubair
authors.affiliation: Rajiv Gandhi Centre for Diabetes and Endocrinology, J. N. Medical College Hospital, Aligarh Muslim University, Aligarh 202002, India. Electronic address: jamalahmad11@rediffmail.com.
authors.forename: Jamal
authors.initials: J
authors.lastname: Ahmad
mesh_terms: D000328:Adult; D000367:Age Factors; D001786:Blood Glucose; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003929:Diabetic Neuropathies / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007194:India; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D008055:Lipids; D008074:Lipoproteins; D002784:Cholesterol; D003404:Creatinine
keywords: Nerve conduction velocity; Peripheral neuropathy; Type 2 diabetes mellitus