title: Temporal lobe epilepsy surgery modulates the activity of auditory pathway.
abstract: The purpose of this paper is to evaluate the effects of the anterior temporal lobectomy on the functional state of the auditory pathway in a group of drug-resistant epileptic patients, linking the electrophysiological results to the resection magnitude. Twenty-seven patients with temporal lobe epilepsy and a matched control group were studied. Auditory brainstem and middle latency responses (ABR and MLR respectively) were carried out before and after 6, 12 and 24 months surgical treatment. The volume and longitude of temporo-mesial resected structures were estimated on magnetic resonance images taken 6 months after surgery. Before the intervention the patients showed a significant delay of latency in waves III, V, Pa and Nb, with an increase in duration of I-V interval in comparison with healthy subjects (Mann-Whitney U-test, p<0.05). After resection, additional significant differences in waves I and Na latency were observed. Na and Pa waveforms showed a tendency to increase in amplitude, which became statistically significant 12 months after surgery for right hemisphere lobectomized patients in the midline electrode, and in Pa waveform for all patients in the temporal electrodes ipsilateral to resection (Wilcoxon test, p<0.05). In general, latency variations of MLR correlated with resection longitude, while changes in amplitude correlated with the volume of the resection in the middle temporal pole and amygdala (Pearson' correlation test, p<0.05). As a result, we assume that anterior temporal lobectomy provokes functional modifications into the auditory pathway, probably related to an indirect modulation of its activity by the temporo-mesial removed structures.
authors.affiliation: International Center for Neurological Restoration (CIREN), Ave. 25 #15805% 158-160, Havana 11300, Cuba. Electronic address: minou@neuro.ciren.cu.
authors.forename: Margarita Minou
authors.initials: MM
authors.lastname: Báez-Martín
authors.affiliation: International Center for Neurological Restoration (CIREN), Ave. 25 #15805% 158-160, Havana 11300, Cuba.
authors.forename: Lilia María
authors.initials: LM
authors.lastname: Morales-Chacón
authors.affiliation: International Center for Neurological Restoration (CIREN), Ave. 25 #15805% 158-160, Havana 11300, Cuba.
authors.forename: Iván
authors.initials: I
authors.lastname: García-Maeso
authors.affiliation: International Center for Neurological Restoration (CIREN), Ave. 25 #15805% 158-160, Havana 11300, Cuba.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Estupiñán-Díaz
authors.affiliation: International Center for Neurological Restoration (CIREN), Ave. 25 #15805% 158-160, Havana 11300, Cuba.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Lorigados-Pedre
authors.affiliation: International Center for Neurological Restoration (CIREN), Ave. 25 #15805% 158-160, Havana 11300, Cuba.
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: García
authors.affiliation: International Center for Neurological Restoration (CIREN), Ave. 25 #15805% 158-160, Havana 11300, Cuba.
authors.forename: Reynaldo
authors.initials: R
authors.lastname: Galvizu
authors.affiliation: International Center for Neurological Restoration (CIREN), Ave. 25 #15805% 158-160, Havana 11300, Cuba.
authors.forename: Juan E
authors.initials: JE
authors.lastname: Bender
authors.affiliation: International Center for Neurological Restoration (CIREN), Ave. 25 #15805% 158-160, Havana 11300, Cuba.
authors.forename: Ivette
authors.initials: I
authors.lastname: Cabrera-Abreu
authors.affiliation: International Center for Neurological Restoration (CIREN), Ave. 25 #15805% 158-160, Havana 11300, Cuba.
authors.forename: Yamila
authors.initials: Y
authors.lastname: Pérez-Téllez
authors.affiliation: Cuban Neuroscience Center (CNC), Ave. 25 #15202% 158-160, Havana 11300, Cuba.
authors.forename: Lídice
authors.initials: L
authors.lastname: Galán
mesh_terms: D000328:Adult; D038481:Anterior Temporal Lobectomy; D001306:Auditory Pathways / Q000503:physiopathology*; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology / Q000601:surgery*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000502:physiology; D013702:Temporal Lobe / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Auditory brainstem response; Drug-resistant epilepsy; Magnetic resonance imaging; Middle latency response; Temporal lobectomy