title: [24-h intraesophageal pH determination in children allergic to cow's milk protein at a tertiary care hospital].
abstract: BACKGROUND
  Cow's milk protein allergy (CMPA) is being seen more frequently on a daily basis in pediatric consultations. It shares symptoms with gastroesophageal reflux (GER), which can complicate the differential diagnosis.
  
  
  OBJECTIVE
  To attempt to corroborate the presence of acid GER in children with CMPA, as well as to find a characteristic profile through the 24-hour pH monitoring study in children with GER and CMPA METHODS: The intraesophageal pH monitoring studies performed on 47 children with CMPA were reviewed. The measurements in all the studies were carried out within a 24-hour period using Digitrapper® equipment with a multi-use GeroFlex® catheter, after calibration with pH 7 and pH 1 buffer solutions.
  
  
  RESULTS
  Of the 47 children, 23 were boys (32.4%) and 24 were girls (33.8%) and the mean age was 5±3.7 years. Fourteen of the 47 children (29%) presented with GER, according to the result of the 24-hour intraesophageal measurement. Only 2 of the 47 patients studied fit the phasic profile.
  
  
  CONCLUSIONS
  The findings show the existing relation between the two pathologies. Nevertheless, it is important to determine the presence of non-acid or weak acid reflux, because their existence can increase this association.
authors.affiliation: Instituto Nacional de Pediatría, México DF, México.
authors.forename: J A
authors.initials: JA
authors.lastname: Ramírez-Mayans
authors.affiliation: Instituto Nacional de Pediatría, México DF, México. Electronic address: emtoromonjaraz@hotmail.com.
authors.forename: E M
authors.initials: EM
authors.lastname: Toro-Monjaraz
authors.affiliation: Instituto Nacional de Pediatría, México DF, México.
authors.forename: J
authors.initials: J
authors.lastname: Romero-Trujillo
authors.affiliation: Instituto Nacional de Pediatría, México DF, México.
authors.forename: R
authors.initials: R
authors.lastname: Cervantes-Bustamante
authors.affiliation: Instituto Nacional de Pediatría, México DF, México.
authors.forename: F
authors.initials: F
authors.lastname: Zárate-Mondragón
authors.affiliation: Instituto Nacional de Pediatría, México DF, México.
authors.forename: E
authors.initials: E
authors.lastname: Montijo-Barrios
authors.affiliation: Instituto Nacional de Pediatría, México DF, México.
authors.forename: J
authors.initials: J
authors.lastname: Cadena-León
authors.affiliation: Instituto Nacional de Pediatría, México DF, México.
authors.forename: M
authors.initials: M
authors.lastname: Cazares-Méndez
mesh_terms: D000818:Animals; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D004947:Esophagus / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D016269:Milk Hypersensitivity / Q000150:complications / Q000378:metabolism*; D008894:Milk Proteins / Q000276:immunology*; D062606:Tertiary Care Centers
chemical_list: D008894:Milk Proteins
keywords: Alergia a las proteínas de la leche de vaca; Cow's milk protein allergy; Gastroesophageal reflux; Intraesophageal pH monitoring; Monitorización de pH intraesofágico; Reflujo gastroesofágico