title: Association studies of cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1) gene polymorphisms with acute rejection in kidney transplantation recipients.
abstract: Recent studies have shown that single-nucleotide polymorphisms (SNPs) are associated with allograft rejection in kidney transplantation recipients. We evaluated the possible association between SNPs of the cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1) gene, and acute rejection (AR) among renal transplant patients in a Korean population. We conducted a case-control association study in 63 AR and 284 non-AR kidney transplant recipients. The SNPs of CYP2E1 were genotyped by direct sequencing. Recipient sex (p = 0.023) and the use of tacrolimus (p = 0.017) were significantly different between the two groups. The use of mycophenolate mofetil (MMF) and antibody induction therapy was significantly lower in the AR group. Multiple logistic regression models (codominant, dominant, recessive, and log-additive models) adjusted by sex and type of immunosuppressive regimens were applied to determine the odds ratios (ORs), 95% confidence intervals (CIs), and p-values. The rs2515641 of CYP2E1 showed significant differences between the AR patient group and non-AR group (p = 0.003, OR = 2.55, 95% CI = 1.37-4.75 in the codominant 1 model; p = 0.002, OR = 2.61, 95% CI = 1.43-4.77 in the dominant model; p = 0.0035, OR = 2.13, 95% CI = 1.29-3.50 in the log-additive model). The allele of the rs2515641 SNP also showed a significant association (p = 0.004, OR = 1.99, 95% CI = 1.24-3.21). This study suggests that the CYP2E1 polymorphism may be related to the development of AR in Korean kidney transplantation recipients.
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Park
authors.forename: Hosik
authors.initials: H
authors.lastname: Seok
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: Jeon
authors.forename: Tae Won
authors.initials: TW
authors.lastname: Lee
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Moon
authors.forename: Chun Gyoo
authors.initials: CG
authors.lastname: Ihm
authors.forename: Tae Hee
authors.initials: TH
authors.lastname: Kim
authors.forename: Yeong Hoon
authors.initials: YH
authors.lastname: Kim
authors.forename: Sun Woo
authors.initials: SW
authors.lastname: Kang
authors.forename: Seok Ju
authors.initials: SJ
authors.lastname: Park
authors.forename: Kyung Hwan
authors.initials: KH
authors.lastname: Jeong
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D056726:Genetic Association Studies; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D019392:Cytochrome P-450 CYP2E1
keywords: CYP2E1; acute rejection; association; kidney transplantation; polymorphism