title: Malignant peripheral nerve sheath tumour of penis.
abstract: Malignant peripheral nerve sheath tumour (MPNST) is a rare variety of soft tissue sarcoma that originates from Schwann cells or pluripotent cells of neural crest origin. They have historically been difficult tumours to diagnose and treat. Surgery is the mainstay of treatment with a goal to achieve negative margins. Despite aggressive surgery and adjuvant therapy, the prognosis of patients with MPNST remains poor. MPNST arising from penis is a very rare entity; thus, it presents a diagnostic and therapeutic challenge. We present a case of penile MPNST in a 38-year-old man in the absence of neurofibromatosis treated with surgery followed by post-operative radiotherapy to a dose of 60 Gray in 30 fractions and adjuvant chemotherapy with ifosfamide and adriamycin.
authors.affiliation: Department of Radiation Oncology, Dr BRA Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: J
authors.initials: J
authors.lastname: Kaur
authors.forename: R
authors.initials: R
authors.lastname: Madan
authors.forename: L
authors.initials: L
authors.lastname: Singh
authors.forename: D N
authors.initials: DN
authors.lastname: Sharma
authors.forename: P K
authors.initials: PK
authors.lastname: Julka
authors.forename: G K
authors.initials: GK
authors.lastname: Rath
authors.forename: S
authors.initials: S
authors.lastname: Roy
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use; D008297:Male; D009442:Neurilemmoma / Q000473:pathology* / Q000628:therapy; D010412:Penile Neoplasms / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin; D007069:Ifosfamide
keywords: malignant peripheral nerve sheath tumour; multimodality; penis; treatment