title: Two elderly cases of familial mediterranean fever with rheumatoid arthritis.
abstract: Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder that usually develops before 20 years of age and is characterized by periodic fever with serositis and arthritis. Both FMF and rheumatoid arthritis (RA) involve arthritis; however, their coexistence is rare. We describe two RA patients with an MEFV mutation in exon 2, who were diagnosed with FMF at an age of over 50 years. We also discuss the possibility that MEFV mutations could modulate RA disease activity.
authors.affiliation: Nagasaki Medical Hospital of Rheumatology, Nagasaki, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Matsuoka
authors.affiliation: Nagasaki Medical Hospital of Rheumatology, Nagasaki, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Iwanaga
authors.affiliation: Nagasaki Medical Hospital of Rheumatology, Nagasaki, Japan.
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Ichinose
authors.affiliation: Nagasaki Medical Hospital of Rheumatology, Nagasaki, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Fujiyama
authors.affiliation: Nagasaki Medical Hospital of Rheumatology, Nagasaki, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsuboi
authors.affiliation: Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Hospital, Nagasaki, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
authors.affiliation: Department of Rheumatology, Clinical Research Center, NHO National Nagasaki Medical Center, Omura, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
mesh_terms: D017668:Age of Onset; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D005091:Exons; D010505:Familial Mediterranean Fever / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D009154:Mutation; D010641:Phenotype; D000071198:Pyrin / Q000235:genetics*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D007166:Immunosuppressive Agents; C000604192:MEFV protein, human; D000071198:Pyrin
keywords: MEFV gene; familial Mediterranean fever; rheumatoid arthritis