title: Irregular arrangement of collecting venules (IRAC) provides a critical endoscopic insight inHelicobacter pylori-induced gastritis: A secondary publication.
abstract: The aim of this study was to evaluate the significance of an endoscopic atrophic border and irregular arrangement of collecting venules (IRAC) in the diagnosis ofHelicobacter pylori(H. pylori)-induced gastritis. Upper gastrointestinal tract endoscopy was performed on 723 patients, who were screened them forH. pyloriinfection. Any patients who had undergoneH. pylorieradication therapy were excluded from the study. The endoscopic atrophic border and IRAC in each patient were assessed. TheH. pyloristatus was determined in the patients by combination of a serological test and/or histopathological examination. TheH. pyloriinfection rates were 95.4% (455/477) in the group with an endoscopic atrophic border and 22.3% (55/246) in the group without an endoscopic atrophic border. In the diagnostic validity check, presence of an endoscopic atrophic border had a sensitivity of 89.2% and a specificity of 89.7%. Furthermore, theH. pyloriinfection rates were 95.5% (506/530) in the IRAC group and 2.1% (4/193) in the regular arrangement of collecting venules (RAC) group. In the diagnostic validity check, IRAC had a sensitivity of 99.2% and a specificity of 88.7%. In conclusion, the presence of an endoscopic atrophic border and IRAC are highly indicative of anH. pylori-infected gastric mucosa.
authors.affiliation: Katake Clinic (Ichouka Naika), Hyogo;
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katake
authors.affiliation: Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Tochigi;
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Ichikawa
authors.affiliation: Fujio Clinic, Hyogo;
authors.forename: Chikau
authors.initials: C
authors.lastname: Fujio
authors.affiliation: Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Tochigi;
authors.forename: Shigeki
authors.initials: S
authors.lastname: Tomita
authors.affiliation: Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
authors.forename: Johji
authors.initials: J
authors.lastname: Imura
authors.affiliation: Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Tochigi;
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujimori
keywords: Helicobacter pylori; endoscopic diagnosis; irregular arrangement of collecting venules; regular arrangement of collecting venules