title: An examination of 1-year adherence and persistence rates to antiepileptic medication in children with newly diagnosed epilepsy.
abstract: OBJECTIVE
  The primary aim of the current study was to use new methods to examine 1-year quality of medication dosing (adherence) and continuation with medication treatment (persistence) rates to antiepileptic drugs (AEDs) in children with newly diagnosed epilepsy.
  
  
  METHODS
  Medication-taking behaviors of AEDs were assessed using electronic monitors for 117 children with newly diagnosed epilepsy for the first year after diagnosis.
  
  
  RESULTS
  Approximately 15% of participants were categorized as nonpersistent (i.e., failed to take medication for >15 consecutive days) 6 months after AED initiation, which increased to 26.6% of participants at 1 year. The majority of medication dosing events took place within a +/-2-hr interval as recommended. The group with lower socioeconomic status demonstrated more nonpersistence over time.
  
  
  CONCLUSIONS
  Examining adherence and persistence in medication taking behaviors may yield different types of data for clinical and research purposes.
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Department of Neurology and Sibley Heart Center Cardiology, Children's Healthcare of Atlanta, and Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center Department of Pediatrics, Emory University School of Medicine, Department of Neurology and Sibley Heart Center Cardiology, Children's Healthcare of Atlanta, and Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center Department of Pediatrics, Emory University School of Medicine, Department of Neurology and Sibley Heart Center Cardiology, Children's Healthcare of Atlanta, and Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center baylwar@emory.edu.
authors.forename: Brandon S
authors.initials: BS
authors.lastname: Aylward
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Department of Neurology and Sibley Heart Center Cardiology, Children's Healthcare of Atlanta, and Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Rausch
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Department of Neurology and Sibley Heart Center Cardiology, Children's Healthcare of Atlanta, and Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center.
authors.forename: Avani C
authors.initials: AC
authors.lastname: Modi
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D012107:Research Design
chemical_list: D000927:Anticonvulsants
keywords: adherence; chronic illness; neurological disorders; research design and methods