title: Optic chiasm involvement on MRI with ethambutol-induced bitemporal hemianopia.
abstract: While ethambutol optic neuropathy usually causes central or cecocentral scotomas, bitemporal visual field defects also have been reported. The pathogenesis of the bitemporal hemianopia has not been established. This article describes magnetic resonance imaging abnormalities involving the optic chiasm in a patient with bitemporal visual field loss. To our knowledge, these neuroimaging findings have not been previously described in association with ethambutol therapy.
authors.affiliation: Neuro-Ophthalmology Section, Division of Neurology, Departments of Medicine, Ophthalmology and Vision Sciences (VBO, JAS, SAA, ANES) and Medical Imaging (RIF), University Health Network, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Vivian B
authors.initials: VB
authors.lastname: Osaguona
authors.forename: James A
authors.initials: JA
authors.lastname: Sharpe
authors.forename: Samira A
authors.initials: SA
authors.lastname: Awaji
authors.forename: Richard I
authors.initials: RI
authors.lastname: Farb
authors.forename: Arun N E
authors.initials: AN
authors.lastname: Sundaram
mesh_terms: D000368:Aged; D000995:Antitubercular Agents / Q000009:adverse effects*; D004977:Ethambutol / Q000009:adverse effects*; D005260:Female; D006423:Hemianopsia / Q000139:chemically induced* / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009897:Optic Chiasm / Q000473:pathology*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D000995:Antitubercular Agents; D004977:Ethambutol