title: Polymorphisms of DNA repair and oxidative stress genes in B-cell lymphoma patients.
abstract: The purpose of the study was to investigate the possible association betweenERCC2rs28365048,ERCC5rs17655,XRCC3rs861539 andNOS2Ars2297518 polymorphisms with B-cell lymphoma. The study was conducted on 189 patients with CD20+B-cell lymphoma and 193 controls. The genotype frequencies were compared in the patient and control groups using quantitative polymerase chain reaction, based on allelic discrimination analysis. Our results indicated that variation inNOS2Amay be significant in B-cell lymphoma in a population ≥50 years old (OR=2.15; 95% CI, 1.17-3.92; P=0.013). No association was observed between variations inERCC2,ERCC5,XRCC3and B-cell lymphoma in the studied population. Our finding of an association between age andNOS2Apolymorphisms in lymphoma is unique and requires additional studies. The results concerningERCC2,ERCC5andXRCC3variations add additional data to studies on genetic polymorphisms in the DNA repair pathway.
authors.affiliation: Departments of Molecular Biology and.
authors.forename: Anna
authors.initials: A
authors.lastname: Fabisiewicz
authors.affiliation: Departments of Molecular Biology and.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Pacholewicz
authors.affiliation: Lymphoid Malignancies, The Maria Sklodowska-Curie Memorial Institute and Oncology Centre, PL-02-781 Warsaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Paszkiewicz-Kozik
authors.affiliation: Lymphoid Malignancies, The Maria Sklodowska-Curie Memorial Institute and Oncology Centre, PL-02-781 Warsaw, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Walewski
authors.affiliation: Departments of Molecular Biology and.
authors.forename: Janusz A
authors.initials: JA
authors.lastname: Siedlecki
keywords: B-cell lymphoma; DNA repair; oxidative stress; polymorphism; single nucleotide polymorphism