title: [The participation of matrix metalloproteinases-9 and TIMP-1 in formation of atrial fibrillation paroxisms in patients with metabolic syndrome].
abstract: The aim of this study was to estimate the role of matrix metalloproteinases activity (MMP-9, TIMP-1) and gene polymorphism at the patients with metabolic syndrome in combination with paroxysmal form of atrial fibrillation. The 60 patients with metabolic syndrome in combination with paroxysmal form of atrial fibrillation were investigated with estimation of serum levels of MMP-9, TIMP-1 and mutation of genes of angiotenzinogen 1 Thr 174 Met, angiotenzinogen 2 Met 235 Thr and apolipoprorein C3 C3238 G. In patients with metabolic syndrome in combination with paroxysmal form of atrial fibrillation the significant increase synthesis of MMP-9 level can lead to increase of atrial fibrillation paroxysms because of increase synthesis of collagen tissue in myocard and vessel walls. Also the significant high incidence of angiotenzinogen 2 Met 235 Thr mutation was established.
authors.forename: V A
authors.initials: VA
authors.lastname: Akhmedov
authors.forename: V T
authors.initials: VT
authors.lastname: Dolgikh
authors.forename: D V
authors.initials: DV
authors.lastname: Naumov
authors.forename: N A
authors.initials: NA
authors.lastname: Nechiporenko
mesh_terms: D000328:Adult; D000803:Angiotensin I / Q000235:genetics; D000804:Angiotensin II / Q000235:genetics; D001056:Apolipoproteins C / Q000235:genetics; D001281:Atrial Fibrillation / Q000097:blood* / Q000209:etiology / Q000235:genetics; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*
chemical_list: D001056:Apolipoproteins C; C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; D000804:Angiotensin II; D000803:Angiotensin I; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9