title: Impaired endothelial function in patients with Takayasu's arteritis.
abstract: OBJECTIVE
  Takayasu's arteritis (TAK) is a chronic, inflammatory, large-vessel vasculitis. In this study we aimed to evaluate vascular endothelial function by brachial ultrasonography and to evaluate carotid artery intima-media thickness (CIMT) in patients with TAK compared to systemic lupus erythematosus (SLE) and healthy controls.
  
  
  METHODS
  The study included 32 patients with TAK, fulfilling the 1990 Classification Criteria of American College of Rheumatology (ACR), 18 patients with systemic lupus erythematosus (SLE) classified according to the 1982 ACR Criteria and 20 age- and sex-matched controls. Brachial artery Doppler ultrasonography and bilateral CIMT measurements were performed.
  
  
  RESULTS
  Basal diameter and nitrate-induced dilatation (NID) values of the brachial artery were similar between the three groups. Flow-mediated dilation (FMD) was markedly reduced in patients with TAK compared to controls (P = 0.0001). CIMT was also significantly increased in the TAK group, compared to the controls (P = 0.0001). In the SLE group, a marked impairment in FMD% was also obtained compared to controls (P = 0.0001). CIMT measurement was similar between the patients with SLE and the controls (P = 0.60, P = 0.05).
  
  
  CONCLUSIONS
  We detected significantly decreased FMD and increased CIMT in TAK, suggesting a marked endothelial dysfunction. Both chronic systemic inflammation and vasculitis might lead to endothelial dysfunction and increased atherosclerosis in TAK, suggesting that management of cardiovascular risk factors are also important in the management of vasculitis.
authors.forename: Fatma
authors.initials: F
authors.lastname: Alibaz-Oner
authors.forename: Selen
authors.initials: S
authors.lastname: Yurdakul
authors.forename: Saide
authors.initials: S
authors.lastname: Aytekin
authors.forename: Haner
authors.initials: H
authors.lastname: Direskeneli
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013625:Takayasu Arteritis / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D018608:Ultrasonography, Doppler / Q000379:methods; D014664:Vasodilation