title: Polymorphisms of +2836 G>A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population.
abstract: In the present study, the correlation of polymorphisms of the apolipoprotein E (apoE) gene with the susceptibility of essential hypertension (EH) was investigated. Single nucleotide polymorphisms of the apoE gene at the -491 A>T, +969 C>G, and +2836 G>A sites were determined in 221 non-EH individuals and 109 subjects with EH of Chinese Hui ethnicity using polymerase chain reaction-restriction fragment length polymorphism analysis. The results showed that neither the genotypic frequency nor the allelic frequency at the -491 A>T and +969 C>G sites exhibited a statistically significant difference between these two groups (P > 0.05). However, a significant difference was observed in genotypic frequency and allelic frequency at the +2836 G>A site between EH patients and non-EH individuals (P < 0.01). In addition, a significantly higher frequency of the A allele at the +2836 G>A site was also detected in EH patients (83%) compared with controls (47.5%) (P < 0.01; OR = 4.82, 95%CI = 3.25-7.17); in contrast, the frequency of the G allele at the +2836 G>A site was significantly lower (17%) in the patient group in comparison with the non-EH cohorts (52.5%) (P < 0.01; OR = 0.21, 95%CI = 0.14-0.31). These results suggest that the polymorphism at the +2836 G>A site in the apoE gene is strongly correlated with the susceptibility to EH in the Chinese Hui ethnic population.
authors.affiliation: Key Laboratory of the Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China, Yinchuan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Key Laboratory of the Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China, Yinchuan, China.
authors.forename: J R
authors.initials: JR
authors.lastname: Xu
authors.affiliation: Key Laboratory of the Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China, Yinchuan, China.
authors.forename: X M
authors.initials: XM
authors.lastname: Liu
authors.affiliation: Key Laboratory of the Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China, Yinchuan, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Key Laboratory of the Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China, Yinchuan, China.
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.affiliation: Key Laboratory of the Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China, Yinchuan, China.
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.affiliation: Key Laboratory of the Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China, Yinchuan, China wyj@nxu.edu.cn.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D000225:Adenine / Q000378:metabolism; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D000075222:Essential Hypertension; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006147:Guanine / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D001057:Apolipoproteins E; D006147:Guanine; D000225:Adenine