title: Predictive value of electroencephalography for seizure outcome following corpus callosotomy in children.
abstract: OBJECTIVE
  This study aimed to determine whether preoperative or postoperative electroencephalography (EEG) can predict surgical outcome for corpus callosotomy.
  
  
  METHODS
  We retrospectively reviewed the medical records of 16 patients enrolled. We compared postoperative seizure outcome according to seizure type, preoperative interictal EEG, preoperative ictal EEG, and postoperative interictal EEG. Seizure outcome was classified according to postoperative seizure reduction, i.e., seizure free, >90%, 50-90%, <50%, and no change or worsened. A seizure reduction of 50% or more was judged as a "favorable outcome".
  
  
  RESULTS
  Most patients showed a favorable outcome (12 patients, 75%) and two patients became seizure free (13%). Atonic seizure was most responsive to corpus callosotomy. Preoperative interictal epileptiform discharge had 3 patterns; bilateral independent, generalized, and combination of independent and generalized. None of the preoperative interictal epileptiform discharge (EDs) had significant correlation with seizure outcome. The preoperative ictal rhythm did not predict seizure outcome. However disappearance of generalized EDs on postoperative EEG was correlated with favorable seizure outcome.
  
  
  CONCLUSIONS
  The presence of generalized EDs on postoperative interictal EEG predicted seizure outcome, whereas preoperative EEG did not.
authors.affiliation: Department of Pediatrics, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine;
authors.forename: Go-Un
authors.initials: GU
authors.lastname: Jeong
authors.affiliation: Department of Pediatrics, Seoul National University College of Medicine, Seoul;
authors.forename: Hunmin
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Seoul National University College of Medicine, Seoul;
authors.forename: Byung Chan
authors.initials: BC
authors.lastname: Lim
authors.affiliation: Department of Pediatrics, Seoul National University College of Medicine, Seoul;
authors.forename: Jong-Hee
authors.initials: JH
authors.lastname: Chae
authors.affiliation: Department of Pediatrics, Seoul National University College of Medicine, Seoul;
authors.forename: Ki Joong
authors.initials: KJ
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Seoul National University College of Medicine, Seoul;
authors.forename: Yong Seung
authors.initials: YS
authors.lastname: Hwang
authors.affiliation: Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Hee
authors.initials: H
authors.lastname: Hwang
keywords: Child; Corpus callosum/surgery; Electroencephalography; Epilepsy/surgery