title: Unicentric mixed variant Castleman disease associated with intrabronchial plasmacytoma.
abstract: Castleman disease (CD), described as a heterogeneous lymphoproliferative disorder, can be divided into different subtypes according to clinical appearance (unicentric and multicentric form) and histopathological features (hyaline vascular, plasma cell, mixed type, human herpesvirus 8-associated and multicentric not otherwise specified). Unicentric CD is known to be usually of the hyaline vascular variant, plasma cell and mixed type of this form are quite uncommon. Malignancies are mainly associated with the multicentric form. We report a rare case of unicentric mixed variant CD evolving into intrabronchial, extramedullary plasmacytoma.Intrabronchial mass with consequential obstruction of the left main bronchus, left lung atelectasis and mediastinal lymphadenomegaly was detected by chest CT in our patient suffering from cough and hemoptysis. Pulmonectomy was performed, histopathological and immunhistochemical analysis of lymph nodes revealed mixed type of CD with interfollicular monotypic plasma cell proliferation. The intrabronchial mass consisted of monotypic plasma cells confirming plasmacytoma. Systemic involvement was not confirmed by further tests.Although malignancies more often present in multicentric CD that usually belongs to the plasma cell subtype, this case confirms the neoplastic potential of the rarest, unicentric mixed variant of CD.
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authors.affiliation: Department of Pulmonology, Semmelweis University, Diósárok u, 1/c, 1125 Budapest, Hungary. noemi.eszes@gmail.com.
authors.forename: Noémi
authors.initials: N
authors.lastname: Eszes
authors.forename: Lilla
authors.initials: L
authors.lastname: Tamási
authors.forename: Attila
authors.initials: A
authors.lastname: Csekeő
authors.forename: Judit
authors.initials: J
authors.lastname: Csomor
authors.forename: Agota
authors.initials: A
authors.lastname: Szepesi
authors.forename: Gergely
authors.initials: G
authors.lastname: Varga
authors.forename: György
authors.initials: G
authors.lastname: Balázs
authors.forename: György
authors.initials: G
authors.lastname: Losonczy
authors.forename: Veronika
authors.initials: V
authors.lastname: Müller
mesh_terms: D005871:Castleman Disease / Q000150:complications* / Q000473:pathology; D015897:Comorbidity; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology; D016481:Helicobacter Infections / Q000453:epidemiology; D006801:Humans; D007889:Leiomyoma / Q000453:epidemiology; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D016584:Panic Disorder / Q000453:epidemiology; D010954:Plasmacytoma / Q000150:complications* / Q000473:pathology; D014594:Uterine Neoplasms / Q000453:epidemiology