title: Invariant NKT cell development: focus on NOD mice.
abstract: Natural killer T (NKT) cells are non-conventional T lymphocytes expressing a TCRαβ and several NK cell markers. Once activated, they can rapidly secrete large amounts of cytokines such as IFN-γ and IL-4. As a result they can favor both Th1 and Th2 immune responses and play a critical role in anti-pathogenic immune responses as well as in regulation of autoimmune diseases. It has now been clearly established that iNKT cells can be subdivided into three subpopulations: iNKT1, iNKT2 and iNKT17 cells. Each of these populations is characterized by the expression of a particular transcription factor, surface markers and cytokines making them functionally distinct. Interestingly, NOD mice developing autoimmune diabetes exhibit a high frequency of iNKT17 cells, which can participate in the disease.
authors.affiliation: INSERM, U1016, Hospital Cochin/St Vincent de Paul, Paris, France; Université Paris Descartes, Laboratoire d'Excellence INFLAMEX, Sorbonne Paris Cité, Paris, France.
authors.forename: Liana
authors.initials: L
authors.lastname: Ghazarian
authors.affiliation: INSERM, U1016, Hospital Cochin/St Vincent de Paul, Paris, France; Université Paris Descartes, Laboratoire d'Excellence INFLAMEX, Sorbonne Paris Cité, Paris, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Simoni
authors.affiliation: INSERM, U1016, Hospital Cochin/St Vincent de Paul, Paris, France; Université Paris Descartes, Laboratoire d'Excellence INFLAMEX, Sorbonne Paris Cité, Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Magalhaes
authors.affiliation: INSERM, U1016, Hospital Cochin/St Vincent de Paul, Paris, France; Université Paris Descartes, Laboratoire d'Excellence INFLAMEX, Sorbonne Paris Cité, Paris, France. Electronic address: agnes.lehuen@inserm.fr.
authors.forename: Agnès
authors.initials: A
authors.lastname: Lehuen
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000276:immunology; D051379:Mice; D016688:Mice, Inbred NOD; D055611:Natural Killer T-Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D011971:Receptors, Immunologic / Q000276:immunology; D015398:Signal Transduction; D014157:Transcription Factors / Q000276:immunology
chemical_list: D016207:Cytokines; D011971:Receptors, Immunologic; D014157:Transcription Factors