title: Myofibroblastoma of the breast with smooth muscle differentiation showing deletion of 13q14 region: report of a case.
abstract: Breast myofibroblastomas are rare benign mesenchymal tumors belonging to the group of stromal breast tumors composed of spindle-shaped cells and characterized by a broad morphologic spectrum. Among the different morphologic variants described, breast MFBs can show smooth muscle cell differentiation in very rare cases. In terms of the genetic abnormalities found in this type of tumor, a deletion of chromosome 13q14 was recently confirmed by FISH in some cases of mammary MFB. In this paper, we report an unusual case of MFB with smooth muscle differentiation showing a deletion of chromosome 13q14.
authors.affiliation: Department of Pathology, Erasme Hospital, Brussels, Belgium. Electronic address: atrepant@ulb.ac.be.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Trépant
authors.affiliation: Department of Genetics, Bordet Institute, Brussels, Belgium.
authors.forename: Catherine
authors.initials: C
authors.lastname: Sibille
authors.affiliation: Department of Radiology, Erasme Hospital, Brussels, Belgium.
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Frunza
authors.affiliation: Department of Gynecology, Erasme Hospital, Brussels, Belgium.
authors.forename: Philippe
authors.initials: P
authors.lastname: Simon
authors.affiliation: Department of Pathology, Erasme Hospital, Brussels, Belgium.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Noël
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics*; D001706:Biopsy; D001943:Breast Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D002454:Cell Differentiation; D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D005260:Female; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000235:genetics*; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D032389:Myocytes, Smooth Muscle / Q000737:chemistry / Q000473:pathology*; D009379:Neoplasms, Muscle Tissue / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D010641:Phenotype; D011237:Predictive Value of Tests; D016217:Ultrasonography, Mammary
chemical_list: D014408:Biomarkers, Tumor; C085126:FOXO1 protein, human; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors
keywords: Breast; Myofibroblastoma; Smooth muscle differentiation