title: A case-control study of high-intensity focused ultrasound combined with sonographically guided intratumoral ethanol injection in the treatment of uterine fibroids.
abstract: OBJECTIVE
  The purpose of this study was to explore the feasibility of high-intensity focused ultrasound combined with sonographically guided intratumoral ethanol injection in the treatment of uterine fibroids and to compare its therapeutic effects and potential side effects with those of simple high-intensity focused ultrasound treatment.
  
  
  METHODS
  Forty patients with uterine fibroids from the Department of Ultrasonography in our hospital were randomly divided into 2 groups of the same size: group H, which only underwent high-intensity focused ultrasound treatment; and group H + A, which underwent sonographically guided intratumoral ethanol injection therapy first and then high-intensity focused ultrasound treatment the following day. The treatment times, treatment doses, pain scores, side effects, and therapeutic effect rates of the groups were then recorded and compared.
  
  
  RESULTS
  Both the treatment time and dose of group H + A were significantly less than those of group H, and the differences were statistically significant (P < .05). A lower pain score and fewer side effects were achieved in group H + A, also with statistically significant differences (P < .05). The therapeutic effect rate of group H + A was also higher than that of group H, and the difference was also statistically significant (P < .05).
  
  
  CONCLUSIONS
  In the treatment of uterine fibroids, high-intensity focused ultrasound combined with sonographically guided intratumoral ethanol injection requires less treatment time and a lower dose than simple high-intensity focused ultrasound treatment and significantly reduces the pain and side effects commonly experienced by patients. High-intensity focused ultrasound combined with sonographically guided intratumoral ethanol injection is a feasible, safe, and more effective way to treat patients with uterine fibroids.
authors.affiliation: Department of Radiology, China-Japan Union Hospital, Jilin University, 126 Xiantai St, Erdao District, 130033 Changchun, Jilin, China. zwyangdogh@gmail.com.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Yang
authors.forename: Yibin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhang
authors.forename: Jijiang
authors.initials: J
authors.lastname: Ma
authors.forename: Jinyu
authors.initials: J
authors.lastname: Chen
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Kaihui
authors.initials: K
authors.lastname: Jiang
authors.forename: Danmei
authors.initials: D
authors.lastname: Mu
authors.forename: Yingjiao
authors.initials: Y
authors.lastname: Yu
authors.forename: Haishan
authors.initials: H
authors.lastname: Yang
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy / Q000379:methods; D000431:Ethanol / Q000008:administration & dosage*; D005240:Feasibility Studies; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D007889:Leiomyoma / Q000000981:diagnostic imaging / Q000628:therapy*; D008875:Middle Aged; D012597:Sclerosing Solutions / Q000008:administration & dosage; D015911:Sclerotherapy / Q000379:methods*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*
chemical_list: D012597:Sclerosing Solutions; D000431:Ethanol
keywords: ethanol; gynecologic ultrasound; high-intensity focused ultrasound; uterine fibroids