title: Autoimmune encephalitis update.
abstract: Cancer-associated immune-mediated disorders of the central nervous system are a heterogeneous group. These disorders include the classic paraneoplastic neurologic disorders and the more recently described autoimmune encephalitis associated with antibodies to neuronal cell-surface or synaptic receptors that occur with and without a cancer association. Autoimmune encephalitis is increasingly recognized as the cause of a variety of neuropsychiatric syndromes that can be severe and prolonged. In contrast to the classic paraneoplastic disorders that are poorly responsive to tumor treatment and immunotherapy, autoimmune encephalitis often responds to these treatments, and patients can have full or marked recoveries. As early treatment speeds recovery, reduces disability, and decreases relapses that can occur in about 20% of cases, it is important that the immune pathogenesis of these disorders is recognized.
authors.affiliation: Institució Catalana de Recerca i Estudis Avançats (ICREA) at Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Department of Neurology, Hospital Clínic, University of Barcelona, Barcelona, Spain (J.D.); Hospital Clínic/IDIBAPS, Department of Neurology, Barcelona, Spain (M.R.R.).
authors.forename: Josep
authors.initials: J
authors.lastname: Dalmau
authors.affiliation: Institució Catalana de Recerca i Estudis Avançats (ICREA) at Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Department of Neurology, Hospital Clínic, University of Barcelona, Barcelona, Spain (J.D.); Hospital Clínic/IDIBAPS, Department of Neurology, Barcelona, Spain (M.R.R.).
authors.forename: Myrna R
authors.initials: MR
authors.lastname: Rosenfeld
mesh_terms: D000906:Antibodies / Q000276:immunology; D001927:Brain Diseases / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D004660:Encephalitis; D050031:Hashimoto Disease / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D006801:Humans
chemical_list: D000906:Antibodies
keywords: antibodies; autoimmune; encephalitis; paraneoplastic; synaptic antigens