title: Measuring steady-state cerebral vasomotor reactivity using non-triggered phase-contrast magnetic resonance imaging.
abstract: To investigate cVMR by using CO2-based hypercapnic challenge and blood flow monitoring employing non-triggered phase contrast (PC) magnetic resonance imaging. Six healthy volunteers (6 male; mean age: 29 years) participated this study after providing institutionally approved consent. This study used non-triggered PC imaging to increase temporal resolution of dynamic blood flow measurements, allowing real-time monitoring of the hypercapnic challenge response. Results suggest that vasomotor reactivity measured by non-triggered PC imaging is positively associated with the concentration of inhaled CO2. This study concludes that CO2 challenge combined with non-triggered PC flow imaging is potentially useful to provide diagnostic information for patients with cerebrovascular disease.
authors.affiliation: Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan, ROC.
authors.forename: Chun-Jung
authors.initials: CJ
authors.lastname: Juan
authors.affiliation: Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, ROC. Electronic address: ericliu6@ms35.hinet.net.
authors.forename: Yi-Jui
authors.initials: YJ
authors.lastname: Liu
authors.affiliation: Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, ROC.
authors.forename: Teng-Yi
authors.initials: TY
authors.lastname: Huang
authors.affiliation: Graduate Institute of Clinical Medcine, Taipei Medical University, Taipei, Taiwan, ROC.
authors.forename: Cheng-Yu
authors.initials: CY
authors.lastname: Chen
authors.affiliation: Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan, ROC.
authors.forename: Guo-Shu
authors.initials: GS
authors.lastname: Huang
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002245:Carbon Dioxide / Q000008:administration & dosage*; D002536:Cerebral Arteries / Q000187:drug effects / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003287:Contrast Media; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology; D014666:Vasomotor System / Q000187:drug effects / Q000502:physiology*
chemical_list: D003287:Contrast Media; D002245:Carbon Dioxide
keywords: Blood flow; Cerebral vasomotor reactivity; MR phase contrast