title: Mechanics of biological networks: from the cell cytoskeleton to connective tissue.
abstract: From the cell cytoskeleton to connective tissues, fibrous networks are ubiquitous in metazoan life as the key promoters of mechanical strength, support and integrity. In recent decades, the application of physics to biological systems has made substantial strides in elucidating the striking mechanical phenomena observed in such networks, explaining strain stiffening, power law rheology and cytoskeletal fluidisation - all key to the biological function of individual cells and tissues. In this review we focus on the current progress in the field, with a primer into the basic physics of individual filaments and the networks they form. This is followed by a discussion of biological networks in the context of a broad spread of recent in vitro and in vivo experiments.
authors.affiliation: Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, UK. emt1000@cam.ac.uk.
authors.forename: Robyn H
authors.initials: RH
authors.lastname: Pritchard
authors.forename: Yan Yan Shery
authors.initials: YY
authors.lastname: Huang
authors.forename: Eugene M
authors.initials: EM
authors.lastname: Terentjev
mesh_terms: D000199:Actins / Q000737:chemistry*; D001696:Biomechanical Phenomena; D003238:Connective Tissue; D003599:Cytoskeleton / Q000737:chemistry*; D004548:Elasticity; D008870:Microtubules / Q000737:chemistry; D012212:Rheology; D013314:Stress, Mechanical
chemical_list: D000199:Actins