title: Usefulness of catestatin to predict malignant arrhythmia in patients with acute myocardial infarction.
abstract: Catestatin (CST) displays potent vasodilatory effect and acts on lowering blood pressure in vivo. The clinical utility of CST in patients with acute myocardial infarction (AMI) has not been clearly delineated. The aim of this study was to investigate the predictive value of CST for the development of in-hospital malignant arrhythmia and other adverse cardiac events in patients with AMI. A total of 125 consecutive patients diagnosed with AMI were included. The clinical characteristics and previous history of the patients were collected. Malignant arrhythmia and other major adverse cardiac events (MACE) such as postinfarction angina pectoris or reinfarction and death were recorded during hospitalization. The levels of plasma CST, norepinephrine (NE) and amino-terminal pro-brain sodium peptides (NT-proBNP) were determined by sandwich ELISA. A multiple logistic regression model was used to predict the influence factors of malignant arrhythmia and other MACE during hospitalization of AMI patients. The results showed that the levels of plasma cystatin-C (CysC), high sensitivity C-reactive protein (hs-CRP), NE and NT-proBNP increased in a CST concentration dependent manner. The incidence of malignant arrhythmia significantly increased as the elevation of CST level (P<0.05). Age, CST and NT-proBNP were independent predictors for the MACE occurred during hospitalization. Increased blood glucose (≥6.1mmol/L) and CST were independent predictors for the complicated malignant arrhythmia of AMI patients. These data demonstrated that CST can be used as a new biological marker for prediction of malignant arrhythmia in patients with AMI.
authors.affiliation: Intervention Division, Taiyuan City Centre Hospital, Taiyuan 030001, China. Electronic address: pzq2005122811@163.com.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Pei
authors.affiliation: Intervention Division, Taiyuan City Centre Hospital, Taiyuan 030001, China.
authors.forename: Dengfeng
authors.initials: D
authors.lastname: Ma
authors.affiliation: Cadre Health Centre, Qinghai People's Hospital, Xining 810000, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Ji
authors.affiliation: Intervention Division, Taiyuan City Centre Hospital, Taiyuan 030001, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Intervention Division, Taiyuan City Centre Hospital, Taiyuan 030001, China.
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Su
authors.affiliation: Intervention Division, Taiyuan City Centre Hospital, Taiyuan 030001, China.
authors.forename: Weizhen
authors.initials: W
authors.lastname: Xue
authors.affiliation: Intervention Division, Taiyuan City Centre Hospital, Taiyuan 030001, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Senile Internal Medicine, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Weishu
authors.initials: W
authors.lastname: Wang
mesh_terms: D000208:Acute Disease; D017677:Age Distribution; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D053379:Chromogranin A / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood*; D011498:Protein Precursors / Q000097:blood; D013318:Stroke Volume
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D053379:Chromogranin A; D010446:Peptide Fragments; D011498:Protein Precursors; C109084:chromogranin A (344-364); D020097:Natriuretic Peptide, Brain
keywords: Acute myocardial infarction; Adverse cardiac events; Catestatin