title: The beneficial effect of acromegaly control on blood pressure values in normotensive patients.
abstract: OBJECTIVE
  Control of acromegaly may ameliorate blood pressure (BP) in hypertensive (HT) patients. We evaluated the impact of acromegaly control on BP values of normotensive (NT) acromegalics.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Fifty-eight naïve patients with acromegaly (39 F; age range, 30-69 years), including 28 NT and 30 HT subjects, participated in the study.
  
  
  METHODS
  Blood pressure was measured by clinical measurement and 24-h ambulatory monitoring at diagnosis and after 24 months of medical therapy for acromegaly.
  
  
  RESULTS
  Acromegaly was controlled by medical therapy in 15 NT and 17 HT patients at 24 months. In the NT group, systolic (SBP) or diastolic (DBP) BP significantly increased (all P < 0·005) when acromegaly was uncontrolled, but did not change when the disease was controlled. Changes in SBP and DBP were also significantly different between uncontrolled and controlled NT patients. At 24 months, clinical hypertension was detected only in uncontrolled NT patients (46% vs 0%, P < 0·001), whereas ambulatory hypertension was found in 38% of uncontrolled and in 7% of controlled NT subjects (P = 0·035). In the HT group, ambulatory SBP increased in patients with uncontrolled acromegaly (24-h SBP P = 0·046, day SBP P = 0·005, night SBP P = 0·005), whereas ambulatory DBP decreased in subjects with controlled disease (24-h DBP P = 0·008, day DBP P = 0·026).
  
  
  CONCLUSIONS
  Control of acromegaly has a beneficial effect on BP regulation either in HT or NT subjects; in the latter, it may prevent progression towards hypertension.
authors.affiliation: Endocrinology Section, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Sardella
authors.forename: Claudio
authors.initials: C
authors.lastname: Urbani
authors.forename: Martina
authors.initials: M
authors.lastname: Lombardi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Nuzzo
authors.forename: Luca
authors.initials: L
authors.lastname: Manetti
authors.forename: Isabella
authors.initials: I
authors.lastname: Lupi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rossi
authors.forename: Simone
authors.initials: S
authors.lastname: Del Sarto
authors.forename: Ilaria
authors.initials: I
authors.lastname: Scattina
authors.forename: Vitantonio
authors.initials: V
authors.lastname: Di Bello
authors.forename: Enio
authors.initials: E
authors.lastname: Martino
authors.forename: Fausto
authors.initials: F
authors.lastname: Bogazzi
mesh_terms: D000172:Acromegaly / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors