title: [A woman with polyneuropathy and white nails].
abstract: A 69-year-old woman had a progressive demyelinating and axonal polyneuropathy and a monoclonal gammopathy. Physical examination showed hyperpigmentation, acrocyanosis, white nails and pitting oedema. Additional tests showed polycythemia, thrombocytosis, a high serum VEGF-level, clonal plasma cells on bone marrow biopsy and sclerotic lesions of a cervical rib and the cervical and thoracal spine. POEMS-syndrome was diagnosed.
authors.affiliation: Erasmus MC, Rotterdam.
authors.forename: Wilbert A G
authors.initials: WA
authors.lastname: van der Meijden
authors.forename: Jelmer
authors.initials: J
authors.lastname: Alsma
authors.forename: Pieter A
authors.initials: PA
authors.lastname: van Doorn
mesh_terms: D000368:Aged; D003711:Demyelinating Diseases; D005260:Female; D006801:Humans; D009262:Nails / Q000473:pathology; D016878:POEMS Syndrome / Q000175:diagnosis* / Q000473:pathology; D013131:Spine / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A