title: Validation of the Danish translation of the Medicine Knowledge Questionnaire among elementary school children.
abstract: BACKGROUND
  There is a lack of instruments which can be used to quantitatively assess school children's knowledge about medicine in different countries.
  
  
  OBJECTIVE
  The aim of this study was to validate the Danish translation of a school children's medicine knowledge questionnaire developed in Finland.
  
  
  METHODS
  A total of 685 children from 37 Danish elementary schools, aged 10-14 years, participated in a validation study. Test-retest and inter-rater reliability, as well as known-group-validity of the translated instrument were investigated. Significance level was set at P ≤ 0.05.
  
  
  RESULTS
  For test-retest reliability, Spearman r correlation coefficients for correct knowledge score between the two rounds was 0.433, P < 0.001. For inter-rater reliability, kappa for agreement in correct knowledge score ratings between the two raters was 0.202. For known-group validity, a multivariate linear regression model was run for correct knowledge scores, and it significantly explained 9.2% of variance (R square 0.092, P < 0.001). Gender, school grade and use of medicine for asthma were significant predictors in the model.
  
  
  CONCLUSIONS
  The translated questionnaire showed a fair test-retest and inter-rater reliability, as well as acceptable known-group validity. In order to be reliably used in further studies to evaluate school children's knowledge about medicine in Denmark, the methodic of knowledge scoring in the instrument is warranted.
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Sara
authors.initials: S
authors.lastname: Ramzan
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Ebba Holme
authors.initials: EH
authors.lastname: Hansen
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Lotte Stig
authors.initials: LS
authors.lastname: Nørgaard
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Lourdes Cantarero
authors.initials: LC
authors.lastname: Arevalo
authors.affiliation: Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, Nordre Fasanvej 57, Hovedvejen, Entrance 5, 1st Floor, 2000 Frederiksberg, Denmark. Electronic address: ramune.jacobsen@regionh.dk.
authors.forename: Ramune
authors.initials: R
authors.lastname: Jacobsen
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000188:drug therapy; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D002648:Child; D003718:Denmark; D003920:Diabetes Mellitus / Q000188:drug therapy; D005260:Female; D006261:Headache / Q000188:drug therapy; D006266:Health Education / Q000706:statistics & numerical data*; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D012574:Schools; D013315:Stress, Psychological / Q000188:drug therapy; D013334:Students; D011795:Surveys and Questionnaires
keywords: Knowledge; Medicine; Questionnaire; School children; Validation