title: Early predictive value of multifunctional skin-infiltrating lymphocytes in anticancer immunotherapy.
abstract: Bioassays that predict clinical outcome are essential to optimize cellular anticancer immunotherapy. We have recently developed a robust and simple skin test to evaluate the capacity of tumor-specific T cells to migrate, recognize their targets and exert effector functions. This bioassay detects T cells with an elevated antineoplastic potential and hence rapidly identifies patients responding to immunotherapy.
authors.affiliation: Department of Tumor Immunology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.
authors.forename: Florian
authors.initials: F
authors.lastname: Wimmers
authors.affiliation: Department of Medical Oncology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.
authors.forename: Erik Hjg
authors.initials: EH
authors.lastname: Aarntzen
authors.affiliation: Department of Tumor Immunology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.
authors.forename: Gerty
authors.initials: G
authors.lastname: Schreibelt
authors.affiliation: Department of Laboratory Medicine; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.
authors.forename: Joannes Fm
authors.initials: JF
authors.lastname: Jacobs
authors.affiliation: Department of Medical Oncology; Academic Medical Center; University of Amsterdam; Amsterdam, The Netherlands.
authors.forename: Cornelis
authors.initials: C
authors.lastname: Ja Punt
authors.affiliation: Department of Tumor Immunology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.
authors.forename: Carl G
authors.initials: CG
authors.lastname: Figdor
authors.affiliation: Department of Tumor Immunology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands ; Department of Medical Oncology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.
authors.forename: I Jolanda M
authors.initials: IJ
authors.lastname: de Vries
keywords: DC-based vaccination; biomarker; delayed-type hypersensitivity; immunomonitoring; melanoma; multifunctional T cells; skin-infiltrating lymphocytes