title: The barrier to HIV transmission provided by genital tract Lactobacillus colonization.
abstract: While resistance to HIV transmission is due to multiple mechanisms such as the epithelium, a lower genital tract microbiota dominated by Lactobacillus appears to play an important role. This article reviews selected recent research on genital tract microbiota in women including how microbiota impacts HIV resistance and factors affecting Lactobacillus colonization.
authors.affiliation: Department of Immunology/Microbiology, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Paria
authors.initials: P
authors.lastname: Mirmonsef
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Spear
mesh_terms: D002584:Cervix Uteri / Q000737:chemistry / Q000382:microbiology* / Q000821:virology; D004848:Epithelium / Q000382:microbiology; D005260:Female; D006003:Glycogen / Q000378:metabolism; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007113:Immunity, Innate; D007778:Lactobacillus / Q000276:immunology*; D064307:Microbiota / Q000276:immunology*; D014621:Vagina / Q000737:chemistry / Q000382:microbiology* / Q000821:virology
chemical_list: D006003:Glycogen; D006861:Hydrogen Peroxide
keywords: Genital tract microbiota; HIV transmission; Lactobacillus; glycogen; lactic acid; pH