title: Esthetic outcomes following immediate and early implant placement in the anterior maxilla--a systematic review.
abstract: OBJECTIVE
  The objectives of this systematic review are (1) to quantitatively estimate the esthetic outcomes of implants placed in postextraction sites, and (2) to evaluate the influence of simultaneous bone augmentation procedures on these outcomes.
  
  
  METHODS
  Electronic and manual searches of the dental literature were performed to collect information on esthetic outcomes based on objective criteria with implants placed after extraction of maxillary anterior and premolar teeth. All levels of evidence were accepted (case series studies required a minimum of 5 cases).
  
  
  RESULTS
  From 1,686 titles, 114 full-text articles were evaluated and 50 records included for data extraction. The included studies reported on single-tooth implants adjacent to natural teeth, with no studies on multiple missing teeth identified (6 randomized controlled trials, 6 cohort studies, 5 cross-sectional studies, and 33 case series studies). Considerable heterogeneity in study design was found. A meta-analysis of controlled studies was not possible. The available evidence suggests that esthetic outcomes, determined by esthetic indices (predominantly the pink esthetic score) and positional changes of the peri-implant mucosa, may be achieved for single-tooth implants placed after tooth extraction. Immediate (type 1) implant placement, however, is associated with a greater variability in outcomes and a higher frequency of recession of > 1 mm of the midfacial mucosa (eight studies; range 9% to 41% and median 26% of sites, 1 to 3 years after placement) compared to early (type 2 and type 3) implant placement (2 studies; no sites with recession > 1 mm). In two retrospective studies of immediate (type 1) implant placement with bone graft, the facial bone wall was not detectable on cone beam CT in 36% and 57% of sites. These sites had more recession of the midfacial mucosa compared to sites with detectable facial bone. Two studies of early implant placement (types 2 and 3) combined with simultaneous bone augmentation with GBR (contour augmentation) demonstrated a high frequency (above 90%) of facial bone wall visible on CBCT. Recent studies of immediate (type 1) placement imposed specific selection criteria, including thick tissue biotype and an intact facial socket wall, to reduce esthetic risk. There were no specific selection criteria for early (type 2 and type 3) implant placement.
  
  
  CONCLUSIONS
  Acceptable esthetic outcomes may be achieved with implants placed after extraction of teeth in the maxillary anterior and premolar areas of the dentition. Recession of the midfacial mucosa is a risk with immediate (type 1) placement. Further research is needed to investigate the most suitable biomaterials to reconstruct the facial bone and the relationship between long-term mucosal stability and presence/absence of the facial bone, the thickness of the facial bone, and the position of the facial bone crest.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Chen
authors.forename: Daniel
authors.initials: D
authors.lastname: Buser
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001641:Bicuspid / Q000601:surgery; D016025:Bone Transplantation; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003758:Dental Implantation, Endosseous / Q000379:methods*; D019250:Dental Implants, Single-Tooth; D004955:Esthetics, Dental; D005889:Gingival Recession / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D057893:Immediate Dental Implant Loading / Q000379:methods; D007180:Incisor / Q000601:surgery; D008437:Maxilla / Q000601:surgery; D011859:Radiography; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D014081:Tooth Extraction; D016896:Treatment Outcome