title: [Radiation therapy of cardiac sarcomas].
abstract: OBJECTIVE
  Primary cardiac sarcomas represent less than 10 yearly cases in France. Their median survival is approximately 18 months. The treatment consists of surgery when possible. The role of chemotherapy and radiation therapy is controversial, especially with respect to limiting cardiac radiation dose that is theoretically incompatible with the requirement of a tumoricidal dose for sarcoma. A recent series of 124 cases of the French Sarcoma Group suggested a benefit of radiation therapy on progression-free survival.
  
  
  METHODS
  The dosimetric data of 12 patients were analyzed.
  
  
  RESULTS
  There was variety in radiotherapy modalities and definition of target volumes, doses and techniques are evolving more conformal plans. Irradiation appeared feasible with conventional fractionation with respect to toxicities (although probably underestimated due to short follow-up and dismal prognosis) and previously demonstrated benefit of radiotherapy for primitive cardiac sarcomas.
  
  
  CONCLUSIONS
  A scheme of 45Gy in 1.8Gy per fraction to a preoperative volume with an additional dose of 14Gy in 7 fractions on areas at risk or residual disease and margins 1cm, may be proposed based on the preliminary data of this study. Intensity modulated radiotherapy with daily cone-beam CT-scanner should be evaluated.
authors.affiliation: Département d'oncologie-radiothérapie, centre Antoine-Lacassagne, 227, avenue de la Lanterne, 06200 Nice, France; Université Nice Sophia-Antipolis, 06200 Nice, France. Electronic address: jthariat@hotmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Thariat
authors.affiliation: Oncologie-radiothérapie, centre René-Gauducheau, institut de cancérologie de l'Ouest, 44805 Saint-Herblain, France.
authors.forename: K
authors.initials: K
authors.lastname: Clément-Colmou
authors.affiliation: Oncologie-radiothérapie, centre Alexis-Vautrin, institut de cancérologie de Lorraine, 6, avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.
authors.forename: G
authors.initials: G
authors.lastname: Vogin
authors.affiliation: Oncologie-radiothérapie, centre Alexis-Vautrin, institut de cancérologie de Lorraine, 6, avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.
authors.forename: V
authors.initials: V
authors.lastname: Beckendorf
authors.affiliation: Oncologie-radiothérapie, centre Claudius-Regaud, 20-24, rue du Pont-Saint-Pierre, 31300 Toulouse, France.
authors.forename: A
authors.initials: A
authors.lastname: Ducassou
authors.affiliation: Clinical oncology, Sohag University, Sohag, Égypte.
authors.forename: A M
authors.initials: AM
authors.lastname: Ali
authors.affiliation: Oncologie médicale, CHU la Timone, AP-HM, 264, rue Saint-Pierre, 13005 Marseille, France.
authors.forename: S
authors.initials: S
authors.lastname: Salas
authors.affiliation: Oncologie médicale, centre Antoine-Lacassagne, 227, avenue de la Lanterne, 06200 Nice, France.
authors.forename: E
authors.initials: E
authors.lastname: Saada
authors.affiliation: Oncologie médicale, centre Antoine-Lacassagne, 227, avenue de la Lanterne, 06200 Nice, France.
authors.forename: A
authors.initials: A
authors.lastname: Thyss
authors.affiliation: Oncologie-radiothérapie, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: M
authors.initials: M
authors.lastname: Lapeyre
authors.affiliation: Oncologie médicale, centre Georges-Francois-Leclerc, 1, rue du Professeur-Marion, 21000 Dijon, France.
authors.forename: N
authors.initials: N
authors.lastname: Isambert
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006338:Heart Neoplasms / Q000401:mortality* / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000706:statistics & numerical data; D050397:Radiotherapy, Intensity-Modulated / Q000706:statistics & numerical data; D012509:Sarcoma / Q000401:mortality* / Q000532:radiotherapy*
keywords: Cardiac; Cardiaque; Cœur; Dose; Heart; Radiotherapy; Radiothérapie; Sarcoma; Sarcome; Target volumes; Toxicity; Toxicité; Volumes cibles