title: Pediatric kidney disease: tracking onset and improving clinical outcomes.
abstract: Recent studies confirm that much of adult kidney disease may have its origins in childhood, often as a result of abnormal or suboptimal fetal kidney development. Understanding of the etiology and pathogenesis of CKD in children is rapidly evolving because of robust longitudinal clinical data, identification of monogenic mutations related to common causes of CKD, and improved knowledge of factors that influence the onset and progression of CKD. The Kidney Research National Dialogue, supported by the National Institute of Diabetes and Digestive and Kidney Diseases, asked the research and clinical communities to formulate and prioritize research objectives that would improve understanding of kidney function and diseases. This commentary outlines high-priority research objectives to assess factors associated with the predisposition to develop renal disease in children, and address the unique challenges in treating this population.
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Carlton M
authors.initials: CM
authors.lastname: Bates
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Charlton
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Ferris
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Friedhelm
authors.initials: F
authors.lastname: Hildebrandt
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Deborah K
authors.initials: DK
authors.lastname: Hoshizaki
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Warady
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material. mm726k@nih.gov.
authors.forename: Marva M
authors.initials: MM
authors.lastname: Moxey-Mims
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000628:therapy; D000293:Adolescent; D035843:Biomedical Research; D002648:Child; D002675:Child, Preschool; D004777:Environment; D047109:Fetal Development; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D055118:Medication Adherence; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology*; D012648:Self Care; D060305:Transition to Adult Care; D014564:Urogenital Abnormalities / Q000209:etiology* / Q000235:genetics
keywords: CAKUT; healthcare transition; monogenic; nephron endowment; nonadherence