title: Photo-redox activated drug delivery systems operating under two photon excitation in the near-IR.
abstract: We report the design and synthesis of a nano-container consisting of mesoporous silica nanoparticles with the pore openings covered by "snap-top" caps that are opened by near-IR light. A photo transducer molecule that is a reducing agent in an excited electronic state is covalently attached to the system. Near IR two-photon excitation causes inter-molecular electron transfer that reduces a disulfide bond holding the cap in place, thus allowing the cargo molecules to escape. We describe the operation of the "snap-top" release mechanism by both one- and two-photon activation. This system presents a proof of concept of a near-IR photoredox-induced nanoparticle delivery system that may lead to a new type of photodynamic drug release therapy.
authors.affiliation: Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, California 90095-1569, USA.
authors.forename: Tania M
authors.initials: TM
authors.lastname: Guardado-Alvarez
authors.forename: Lekshmi Sudha
authors.initials: LS
authors.lastname: Devi
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Vabre
authors.forename: Travis A
authors.initials: TA
authors.lastname: Pecorelli
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Schwartz
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Durand
authors.forename: Olivier
authors.initials: O
authors.lastname: Mongin
authors.forename: Mireille
authors.initials: M
authors.lastname: Blanchard-Desce
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Zink
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D004579:Electron Transport; D007259:Infrared Rays; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D017785:Photons; D017319:Photosensitizing Agents / Q000737:chemistry; D016062:Porosity; D012235:Rhodamines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D004337:Drug Carriers; C509968:MCM-41; D017319:Photosensitizing Agents; D012235:Rhodamines; D012822:Silicon Dioxide; C029773:rhodamine B