title: Domino asymmetric conjugate addition-conjugate addition.
abstract: Enantioenriched Al-, Mg-, and Zn-enolates undergo electrophilic trapping by nitroolefins and vinylsulfones to afford 1,4-diketones and 2-(bis(phenylsulfonyl)ethyl)ketones in good yield and excellent diastereoselectivity. A one-pot preparation of indenes and enantiopure syntheses of tetrahydrobenzofurans, tetrahydrobenzopyrroles, and azulenes are disclosed. A site-selective two-step sequence of three conjugate additions is also demonstrated.
authors.affiliation: Department of Organic Chemistry, University of Geneva , Quai Ernest Ansermet, 30, 1211 Geneva 4, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Germain
authors.forename: Doriane
authors.initials: D
authors.lastname: Schlaefli
authors.forename: Mathieu
authors.initials: M
authors.lastname: Chellat
authors.forename: Stéphane
authors.initials: S
authors.lastname: Rosset
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alexakis