title: Measurement of retinal thickness in macular region of high myopic eyes using spectral domain OCT.
abstract: OBJECTIVE
  To investigate the changes of retinal thickness in macula of high myopic eyes using spectral domain optical coherence tomography (OCT).
  
  
  METHODS
  Middle-aged and young myopic patients were divided into three groups according to their refractive error/axial length: low and medium myopia group (LMMG), high myopia group (HMG) and super high myopia group (SHMG). Cirrus HD-OCT was used to evaluate total average macular thickness, central subfield thickness, inner/outer macular thickness and macular volume. The differences among experimental groups were analyzed by one-factor analysis of variance. Associations between macular thickness and refractive error/axial length were analyzed by Pearson correlation analysis.
  
  
  RESULTS
  There was no significant difference in age among the three groups (P=0.2789). The mean refraction error in the LMMG, HMG, and SHMG groups was -2.49±1.38D, -8.53±1.95D and -13.88±1.76D, respectively (P<0.001). The central subfield thickness of three groups was 244.56±12.19µm, 254.33±11.61µm and 261.75±11.83µm, respectively, and there were statistically significance between random two groups. The total average macular thickness, inner/outer macular thickness, and macular volume decreased with increased myopia/axial length. Average foveal thickness had negative correlations with refractive error (P<0.001), and positive correlations with axial length. The inferior and temporal inner macular thickness, all the quadrants of outer ring, total average macular thickness and macular volume featured positive correlations with refractive error, and negative correlations with axial length. Average foveal thickness, superior and temporal inner macular thicknesses, and temporal outer macular thickness was lower in females compared to males.
  
  
  CONCLUSIONS
  With an increase in myopia degree/axial length, the average foveal thickness increased and the inner/outer macular thickness decreased. Females featured thicker average foveal thickness, and thinner macular thickness compared to males.
authors.affiliation: Department of Ophthalmology, Qilu Hospital Affiliated Shandong University, Jinan 250012, Shandong Province, China ; Department of Ophthalmology, Second People's Hospital, Jinan 250001, Shandong Province, China.
authors.forename: Ai-Ping
authors.initials: AP
authors.lastname: Song
authors.affiliation: Department of Ophthalmology, Qilu Hospital Affiliated Shandong University, Jinan 250012, Shandong Province, China.
authors.forename: Xin-Yi
authors.initials: XY
authors.lastname: Wu
authors.affiliation: Department of Ophthalmology, Second People's Hospital, Jinan 250001, Shandong Province, China.
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, Second People's Hospital, Jinan 250001, Shandong Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, Second People's Hospital, Jinan 250001, Shandong Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Ophthalmology, Second People's Hospital, Jinan 250001, Shandong Province, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
keywords: high myopic eyes; optical coherence tomography; retinal thickness