title: Mechanisms of tumour vascularization in cutaneous malignant melanoma: clinical implications.
abstract: Malignant melanoma represents < 10% of all skin cancers but is responsible for the majority of skin-cancer-related deaths. Metastatic melanoma has historically been considered as one of the most therapeutically challenging malignancies. Fortunately, for the first time after decades of basic research and clinical investigation, new drugs have produced major clinical responses. Angiogenesis has been considered an important target for cancer treatment. Initial efforts have focused primarily on targeting endothelial and tumour-related vascular endothelial growth factor signalling. Here, we review different mechanisms of tumour vascularization described in melanoma and discuss the potential clinical implications.
authors.affiliation: Department of Dermatology, Hospital Clínico Universitario 'Lozano Blesa', Zaragoza, 50009, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Pastushenko
authors.forename: P B
authors.initials: PB
authors.lastname: Vermeulen
authors.forename: G G
authors.initials: GG
authors.lastname: Van den Eynden
authors.forename: A
authors.initials: A
authors.lastname: Rutten
authors.forename: F J
authors.initials: FJ
authors.lastname: Carapeto
authors.forename: L Y
authors.initials: LY
authors.lastname: Dirix
authors.forename: S
authors.initials: S
authors.lastname: Van Laere
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D042501:Angiogenic Proteins / Q000502:physiology; D002986:Clinical Trials as Topic; D006801:Humans; D042583:Lymphangiogenesis / Q000502:physiology; D008545:Melanoma / Q000098:blood supply* / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D009857:Oncogenes / Q000502:physiology; D012878:Skin Neoplasms / Q000098:blood supply* / Q000188:drug therapy; D000096142:Cutaneous Malignant Melanoma
chemical_list: D020533:Angiogenesis Inhibitors; D042501:Angiogenic Proteins