title: A novel injectable, cohesive and toughened Si-HPMC (silanized-hydroxypropyl methylcellulose) composite calcium phosphate cement for bone substitution.
abstract: This study reports on the incorporation of the self-setting polysaccharide derivative hydrogel (silanized-hydroxypropyl methylcellulose, Si-HPMC) into the formulation of calcium phosphate cements (CPCs) to develop a novel injectable material for bone substitution. The effects of Si-HPMC on the handling properties (injectability, cohesion and setting time) and mechanical properties (Young's modulus, fracture toughness, flexural and compressive strength) of CPCs were systematically studied. It was found that Si-HPMC could endow composite CPC pastes with an appealing rheological behavior at the early stage of setting, promoting its application in open bone cavities. Moreover, Si-HPMC gave the composite CPC good injectability and cohesion, and reduced the setting time. Si-HPMC increased the porosity of CPCs after hardening, especially the macroporosity as a result of entrapped air bubbles; however, it improved, rather than compromised, the mechanical properties of composite CPCs, which demonstrates a strong toughening and strengthening effect. In view of the above, the Si-HPMC composite CPC may be particularly promising as bone substitute material for clinic application.
authors.affiliation: Université de Nantes, Polytech Nantes, Institut des Matériaux Jean Rouxel, Rue Christian Pauc, BP 50609, 44306 Nantes Cedex 3, France; Université de Nantes, INSERM, UMR 791, LIOAD, Faculté de Chirurgie Dentaire, BP 84215, 44042 Nantes Cedex 1, France.
authors.forename: Weizhen
authors.initials: W
authors.lastname: Liu
authors.affiliation: Université de Nantes, Polytech Nantes, Institut des Matériaux Jean Rouxel, Rue Christian Pauc, BP 50609, 44306 Nantes Cedex 3, France; Université de Nantes, INSERM, UMR 791, LIOAD, Faculté de Chirurgie Dentaire, BP 84215, 44042 Nantes Cedex 1, France.
authors.forename: Jingtao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Université de Nantes, INSERM, UMR 791, LIOAD, Faculté de Chirurgie Dentaire, BP 84215, 44042 Nantes Cedex 1, France; Centre Hospitalier Universitaire de Nantes, 1 place Alexis Ricordeau, 44093 Nantes Cedex 1, France.
authors.forename: Gildas
authors.initials: G
authors.lastname: Rethore
authors.affiliation: Université de Nantes, INSERM, UMR 791, LIOAD, Faculté de Chirurgie Dentaire, BP 84215, 44042 Nantes Cedex 1, France.
authors.forename: Khalid
authors.initials: K
authors.lastname: Khairoun
authors.affiliation: Université de Nantes, INSERM, UMR 791, LIOAD, Faculté de Chirurgie Dentaire, BP 84215, 44042 Nantes Cedex 1, France; Centre Hospitalier Universitaire de Nantes, 1 place Alexis Ricordeau, 44093 Nantes Cedex 1, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Pilet
authors.affiliation: Université de Nantes, Polytech Nantes, Institut des Matériaux Jean Rouxel, Rue Christian Pauc, BP 50609, 44306 Nantes Cedex 3, France. Electronic address: franck.tancret@univ-nantes.fr.
authors.forename: Franck
authors.initials: F
authors.lastname: Tancret
authors.affiliation: Université de Nantes, INSERM, UMR 791, LIOAD, Faculté de Chirurgie Dentaire, BP 84215, 44042 Nantes Cedex 1, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Bouler
authors.affiliation: Université de Nantes, INSERM, UMR 791, LIOAD, Faculté de Chirurgie Dentaire, BP 84215, 44042 Nantes Cedex 1, France; Centre Hospitalier Universitaire de Nantes, 1 place Alexis Ricordeau, 44093 Nantes Cedex 1, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Weiss
mesh_terms: D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates / Q000737:chemistry*; D065347:Hypromellose Derivatives / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D012212:Rheology
chemical_list: D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D065347:Hypromellose Derivatives; C020243:calcium phosphate
keywords: Bone regeneration; Calcium phosphate cements; Hydrogel; Hydroxyapatite; Mechanical properties