title: The association of eGFR reporting with the timing of dialysis initiation.
abstract: Automated reporting of eGFR by laboratories has been widely implemented during the last decade. Over this same period, a steady increase in eGFR at dialysis initiation has been reported. This study examined trends in eGFR at dialysis initiation over time among incident dialysis patient populations before and after eGFR reporting. All patients who initiated dialysis between January of 2001 and December of 2010 in four Canadian provinces that implemented province-wide automated eGFR reporting and had an eGFR measure at dialysis initiation were included in the study (n=22,208). The primary outcome was change over time in eGFR among patients at dialysis initiation. An interrupted time series and adjusted multilevel regression models were used to determine the differences in eGFR at dialysis initiation before and after reporting. We observed a linear increase in the mean eGFR at dialysis initiation from 9.1 to 10.8 ml/min per m(2) during the study period. There was no change in the trajectory of the eGFR at dialysis initiation before or after eGFR reporting in crude or adjusted models accounting for case mix and facility characteristics. These findings were consistent among age and sex strata and when the proportions of patients with an eGFR≥10.5 or ≥12 ml/min per m(2) were examined. In conclusion, automated laboratory-based eGFR reporting did not influence eGFR at dialysis initiation among incident dialysis patient populations. Concerns that widespread eGFR reporting leads to earlier dialysis initiation are not supported by this study.
authors.affiliation: The Ottawa Hospital Research Institute, The Ottawa Hospital, Civic Campus, University of Ottawa, Ottawa, Ontario, Canada; Manishsood999@gmail.com.
authors.forename: Manish M
authors.initials: MM
authors.lastname: Sood
authors.affiliation: Seven Oaks Hospital, University of Manitoba, Winnipeg, Manitoba, Canada; and.
authors.forename: Paul
authors.initials: P
authors.lastname: Komenda
authors.affiliation: Seven Oaks Hospital, University of Manitoba, Winnipeg, Manitoba, Canada; and.
authors.forename: Claudio
authors.initials: C
authors.lastname: Rigatto
authors.affiliation: Cardiac Sciences, St. Boniface Hospital, Winnipeg, Manitoba, Canada.
authors.forename: Brett
authors.initials: B
authors.lastname: Hiebert
authors.affiliation: Seven Oaks Hospital, University of Manitoba, Winnipeg, Manitoba, Canada; and.
authors.forename: Navdeep
authors.initials: N
authors.lastname: Tangri
mesh_terms: D000368:Aged; D057205:Automation, Laboratory / Q000706:statistics & numerical data; D002170:Canada; D015331:Cohort Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests / Q000706:statistics & numerical data / Q000639:trends; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000639:trends; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology* / Q000628:therapy*; D012189:Retrospective Studies; D013997:Time Factors