title: Allergen-specific IgE antibody serologic assays in patients with autoimmune pancreatitis.
abstract: OBJECTIVE
  To clarify the allergic manifestations in patients with autoimmune pancreatitis (AIP).
  
  
  METHODS
  We assessed 67 AIP patients, before they received steroid therapy, for a past history of allergic disease, the peripheral eosinophil count (n=62) and the serum IgE level (n=53). Allergen-specific IgE antibody serologic assays were performed in 15 patients.
  
  
  RESULTS
  A positive past history and/or the presence of active allergic disease were found in 24 AIP patients (36%), including 15 patients with acute allergic rhinitis and eight patients with bronchial asthma. Peripheral eosinophilia and elevation of the serum IgE level were detected in 16% (10/62) and 60% (32/53) of the patients, respectively. Allergen-specific IgE antibody serologic assays were positive in 13 patients (87%). There were no differences between the assay-positive and -negative patients regarding the clinical profiles.
  
  
  CONCLUSIONS
  In conclusion, 87% of the 15 AIP patients tested had positive allergen-specific IgE antibody serologic assays. Allergic mechanisms may be related to the occurrence of AIP.
authors.affiliation: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Japan.
authors.forename: Sawako
authors.initials: S
authors.lastname: Kuruma
authors.forename: Terumi
authors.initials: T
authors.lastname: Kamisawa
authors.forename: Taku
authors.initials: T
authors.lastname: Tabata
authors.forename: Kazuro
authors.initials: K
authors.lastname: Chiba
authors.forename: Susumu
authors.initials: S
authors.lastname: Iwasaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Go
authors.initials: G
authors.lastname: Kuwata
authors.forename: Hideto
authors.initials: H
authors.lastname: Egarashira
authors.forename: Koichi
authors.initials: K
authors.lastname: Koizumi
authors.forename: Satomi
authors.initials: S
authors.lastname: Koizumi
authors.forename: Yuka
authors.initials: Y
authors.lastname: Endo
authors.forename: Junko
authors.initials: J
authors.lastname: Fujiwara
authors.forename: Takeo
authors.initials: T
authors.lastname: Arakawa
authors.forename: Kumiko
authors.initials: K
authors.lastname: Momma
mesh_terms: D000368:Aged; D000485:Allergens / Q000276:immunology*; D000918:Antibody Specificity; D001249:Asthma / Q000097:blood / Q000276:immunology*; D015551:Autoimmunity; D004804:Eosinophils; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000150:complications / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood*; D007564:Japan / Q000453:epidemiology; D007958:Leukocyte Count; D008297:Male; D010195:Pancreatitis / Q000097:blood / Q000209:etiology / Q000276:immunology*; D065631:Rhinitis, Allergic / Q000097:blood / Q000276:immunology*; D012698:Serologic Tests
chemical_list: D000485:Allergens; D007073:Immunoglobulin E