title: Prepulse inhibition of the acoustic startle reflex in high functioning autism.
abstract: BACKGROUND
  High functioning autism is an autism spectrum disorder that is characterized by deficits in social interaction and communication as well as repetitive and restrictive behavior while intelligence and general cognitive functioning are preserved. According to the weak central coherence account, individuals with autism tend to process information detail-focused at the expense of global form. This processing bias might be reflected by deficits in sensorimotor gating, a mechanism that prevents overstimulation during the transformation of sensory input into motor action. Prepulse inhibition is an operational measure of sensorimotor gating, which indicates an extensive attenuation of the startle reflex that occurs when a startling pulse is preceded by a weaker stimulus, the prepulse.
  
  
  METHODS
  In the present study, prepulse inhibition of acoustic startle was compared between 17 adults with high functioning autism and 17 sex-, age-, and intelligence-matched controls by means of electromyography.
  
  
  RESULTS
  Results indicate that participants with high functioning autism exhibited significantly higher startle amplitudes than the control group. However, groups did not differ with regard to PPI or habituation of startle.
  
  
  CONCLUSIONS
  These findings challenge the results of two previous studies that reported prepulse inhibition deficits in high-functioning autism and suggest that sensorimotor gating is only impaired in certain subgroups with autism spectrum disorder.
authors.affiliation: Department for Psychiatry and Psychotherapy, University Hospital of Cologne, Cologne, North Rhine-Westphalia, Germany.
authors.forename: Sina
authors.initials: S
authors.lastname: Kohl
authors.affiliation: Department for Psychiatry and Psychotherapy, University Hospital of Cologne, Cologne, North Rhine-Westphalia, Germany.
authors.forename: Carolin
authors.initials: C
authors.lastname: Wolters
authors.affiliation: Department for Psychiatry and Psychotherapy, University Hospital of Cologne, Cologne, North Rhine-Westphalia, Germany; Department of Economics, Otto-von-Guericke-University, Magdeburg, Saxony-Anhalt, Germany; Center for Behavioral Brain Sciences, Magdeburg, Saxony-Anhalt, Germany.
authors.forename: Theo O J
authors.initials: TO
authors.lastname: Gruendler
authors.affiliation: Department for Psychiatry and Psychotherapy, University Hospital of Cologne, Cologne, North Rhine-Westphalia, Germany; Institute for Neuroscience and Medicine - Cognitive Neuroscience (INM3), Research Center Juelich, Juelich, North Rhine-Westphalia, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Vogeley
authors.affiliation: Department for Psychiatry and Psychotherapy, University Hospital of Cologne, Cologne, North Rhine-Westphalia, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Klosterkötter
authors.affiliation: Department for Psychiatry and Psychotherapy, University Hospital of Cologne, Cologne, North Rhine-Westphalia, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Kuhn
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001321:Autistic Disorder / Q000503:physiopathology* / Q000523:psychology; D016022:Case-Control Studies; D005260:Female; D006185:Habituation, Psychophysiologic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition; D013216:Reflex, Startle