title: The Ca(2+) -activated Cl(-) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis.
abstract: Since anoctamin 1 ANO1 (TMEM16A) was found to be a molecular component of Ca(2+) -activated Cl(-) channels, its role in tumorigenesis has gained attention at a fast pace. ANO1 overexpression frequently occurs in the cancer tissues along with 11q13 chromosome amplification. Poor prognosis of many types of cancers has been closely correlated with ANO1 gene amplification and protein overexpression. ANO1 is now considered an excellent biomarker for certain cancers. Recent research suggests that it is the channel function of ANO1 that is involved in the tumorigenesis. However, how the overexpression of the functional ANO1 causes malignant transformation of tissues via signaling pathways, for example, MAPK remains to be investigated. Clarification of the reasons in future will avail to make ANO1 as a target for cancer treatment.
authors.affiliation: Medical Research Center, Affiliated Hospital, Qingdao University, Qingdao, 266555, China; State Key Physiological Discipline, Qingdao University, Qingdao, 266555, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Qu
authors.forename: Weicheng
authors.initials: W
authors.lastname: Yao
authors.forename: Ruyong
authors.initials: R
authors.lastname: Yao
authors.forename: Xiangping
authors.initials: X
authors.lastname: Liu
authors.forename: Kuai
authors.initials: K
authors.lastname: Yu
authors.forename: Criss
authors.initials: C
authors.lastname: Hartzell
mesh_terms: D000075369:Anoctamin-1; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D018118:Chloride Channels / Q000096:biosynthesis* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020929:Mitogen-Activated Protein Kinase Kinases / Q000235:genetics; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D015398:Signal Transduction / Q000235:genetics
chemical_list: C476213:ANO1 protein, human; D000075369:Anoctamin-1; D018118:Chloride Channels; D009363:Neoplasm Proteins; D020929:Mitogen-Activated Protein Kinase Kinases; D002118:Calcium
keywords: ANO1; Ca2+-activated Cl− channel; cancer; cell proliferation; tumorigenesis