title: Stochastic differential equations as a tool to regularize the parameter estimation problem for continuous time dynamical systems given discrete time measurements.
abstract: In this paper we consider the problem of estimating parameters in ordinary differential equations given discrete time experimental data. The impact of going from an ordinary to a stochastic differential equation setting is investigated as a tool to overcome the problem of local minima in the objective function. Using two different models, it is demonstrated that by allowing noise in the underlying model itself, the objective functions to be minimized in the parameter estimation procedures are regularized in the sense that the number of local minima is reduced and better convergence is achieved. The advantage of using stochastic differential equations is that the actual states in the model are predicted from data and this will allow the prediction to stay close to data even when the parameters in the model is incorrect. The extended Kalman filter is used as a state estimator and sensitivity equations are provided to give an accurate calculation of the gradient of the objective function. The method is illustrated using in silico data from the FitzHugh-Nagumo model for excitable media and the Lotka-Volterra predator-prey system. The proposed method performs well on the models considered, and is able to regularize the objective function in both models. This leads to parameter estimation problems with fewer local minima which can be solved by efficient gradient-based methods.
authors.affiliation: Fraunhofer-Chalmers Centre, Chalmers Science Park, SE-412 88 Gothenburg, Sweden; Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden. Electronic address: jacob.leander@fcc.chalmers.se.
authors.forename: Jacob
authors.initials: J
authors.lastname: Leander
authors.affiliation: Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden.
authors.forename: Torbjörn
authors.initials: T
authors.lastname: Lundh
authors.affiliation: Fraunhofer-Chalmers Centre, Chalmers Science Park, SE-412 88 Gothenburg, Sweden.
authors.forename: Mats
authors.initials: M
authors.lastname: Jirstrand
mesh_terms: D000818:Animals; D003198:Computer Simulation; D017753:Ecosystem; D020387:Food Chain; D016013:Likelihood Functions; D055641:Mathematical Concepts; D008564:Membrane Potentials; D008954:Models, Biological; D008959:Models, Neurological; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D013269:Stochastic Processes; D013997:Time Factors
keywords: Extended Kalman filter; FitzHugh–Nagumo; Lotka–Volterra; Ordinary differential equations; Parameter estimation; Stochastic differential equations