title: VE-cadherin at a glance.
abstract: Although being a monolayer the vascular endothelium controls fundamental vessel functions such as permeability, leukocyte extravasation and angiogenesis. The endothelial selective transmembrane constituent of adherens junctions, Vascular Endothelial- (VE-) cadherin plays a crucial role in the regulation of such activities. The signaling pathways controlled by VE-cadherin as well as the ones that regulate VE-cadherin activity start to be elucidated. This delineates a complex network of molecular and functional interactions that can be altered in pathologies.
authors.affiliation: FIRC Institute of Molecular Oncology (IFOM) Fondazione, Via Adamello 16, 20139, Milan, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Bravi
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Dejana
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Lampugnani
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000502:physiology*; D015820:Cadherins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D000099152:Cadherin 5
chemical_list: D015703:Antigens, CD; D015820:Cadherins; D000099152:Cadherin 5