title: [Characteristics of the course of maxillary sinusitis in children with verified chlamydia infection].
abstract: OBJECTIVE
  To explore the detection rate of chlamydia infection and immunological features of children with acute maxillary sinusitis.
  
  
  METHODS
  Clinical epidemiologic characteristics of the course of acute maxillary sinusitis were studied in the way of medical examination provided for 58 children in the ages from 3 to 15 years, patients of ENT department. In order to identify Chlamydia structures and specific antibodies we used direct (polymerase-chain reaction, direct immune fluorescence) and indirect (immune enzyme analysis) methods. The research for cellular link of immunity was carried out by indirect immune fluorescence technique, using monoclonal antibodies.
  
  
  RESULTS
  The authors report on high level of Chlamydia infection in epithelium of nasal mucosa, and also type structure of verified Chlamydia, clinical signs and peculiarities of immune response in children with acute maxillary sinusitis associated with this infection.
  
  
  CONCLUSIONS
  Chlamydia was detected in 48% of children with acute maxillary sinusitis infection with prevalence of Chlamydophila pneumoniae. Optimal for detection of chlamydia infection is a disease duration not exceeding 2 weeks. The special features of clinical and immunological manifestations in children with acute sinusitis, paired with Chlamydia infection are the more frequent complaints of pain in the affected sinuses, expressed symptoms of intoxication, and the presence of an imbalance in cellular immunity, manifested a relative lymphopenia and activation of T-lymphocytes CD8+.
authors.forename: T A
authors.initials: TA
authors.lastname: Kapustina
authors.forename: E V
authors.initials: EV
authors.lastname: Belova
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002689:Chlamydia / Q000302:isolation & purification*; D002690:Chlamydia Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D015523:Maxillary Sinusitis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D012800:Siberia / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents