title: Role of centrosome in regulating immune response.
abstract: Centrosomes are the vital component of cell cycle progression pathway. Recent investigations have suggested their role in regulating the immune response system. Centrosome polarization delivers secretory granules to the immunological synapse (IS). The Cytotoxic T lymphocytes use a specific mechanism, controlled by centrosome delivery to the plasma membrane for delivering the secretory granules to the immunological synapse. Moreover, the polarization of centrioles to the immunological synapse directs secretion from cytolytic cells of innate as well as adaptive immune systems. Although the recent investigations have suggested their strong role in mediating the crucial events of immunological response, there are few discrepancies that are yet to be resolved. Furthermore, a clear picture of their molecular mechanism along with their cellular functions has not been reported. In this manuscript we have reviewed some important points that explain the importance of centrosomes in mediating the immunological signals and the delivery of lytic discharge from the cytotoxic and killer cells.
authors.forename: Ambuj
authors.initials: A
authors.lastname: Kumar
authors.forename: Vidya
authors.initials: V
authors.lastname: Rajendran
authors.forename: Rao
authors.initials: R
authors.lastname: Sethumadhavan
authors.affiliation: Bioinformatics Division, School of Bio Sciences and Technology, Vellore Institute of Technology University, Vellore 632014, Tamil Nadu, India. riturajpurohit@gmail.com.
authors.forename: Rituraj
authors.initials: R
authors.lastname: Purohit
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D018385:Centrosome / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000502:physiology*; D054992:Immunological Synapses; D007694:Killer Cells, Natural / Q000276:immunology; D022142:Secretory Vesicles / Q000502:physiology; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology*