title: [The influence of intravenous ozone therapy on the electrophysiological properties of myocardium during combined treatment of the patients presenting with arterial hypertension].
abstract: The present investigation included 65 patients (36 men and 29 women of the mean age of 51.3 +/- 6.7 years) presenting with grade I-II arterial hypertension (AH) and undergoing intravenous ozone therapy in combination with the intake of antihypertensive preparations. ECG studies showed that a course of ozone therapy decreases the degree of in homogeneity of intra-myocardial electrophysiological processes in the patients with AH as apparent from reduced dispersion of P-wave and corrected QT-interval. Analysis of the results of high-resolution ECG revealed a significant decrease in the frequency of ventricular late potentials from 29.2% (19 patients) to 13.8% (9 patients) (chi2=4.5; p=0.03) whereas the decrease in the frequency of atrial late potentials was insignificant, from 40% (26 patients) to 29.2% (19 patients) (chi2=1.67; p=0.19). The results of spectral-temporal mapping indicate that a course of ozone therapy resulted in a significant decrease of the total number of local peaks in the QRS complex and the number of peaks with low-amplitude and high-frequency characteristics.
authors.forename: R Kh
authors.initials: RKh
authors.lastname: Gimaev
authors.forename: D P
authors.initials: DP
authors.lastname: Drapova
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Skvortsov
authors.forename: N V
authors.initials: NV
authors.lastname: Olezov
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D010126:Ozone / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D010126:Ozone