title: Liver hepatotoxicity associated with pantoprazole: a rare case report.
abstract: Hepatotoxicity may occasionally develop over the course of treatment with proton pump inhibitors (PPIs). Although skin reactions, interstitial nephritis, pancytopenia, anaphylaxis, and generalized edema have been reported to be associated with PPIs, hepatotoxicity associated with oral pantoprazole is very rare. In this report, we present a case of hepatotoxicity in a 35-year-old man who received pantoprazole (40 mg/day) for acute gastritis. One week after discontinuation of pantoprazole, his liver function began to improve, and the patient gradually fully recovered. Although this toxicity occurs only infrequently, pantoprazole should be considered as a rare hepatotoxic agent in the literature.
authors.affiliation: Medical Faculty, Department of Internal Medicine, Yuzuncu Yil University, 65000, Van, Turkey, m.aslan301@mynet.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Celik
authors.forename: Sevdegul
authors.initials: S
authors.lastname: Karadas
authors.forename: Sehmus
authors.initials: S
authors.lastname: Olmez
authors.forename: Adem
authors.initials: A
authors.lastname: Cifci
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000009:adverse effects*; D015746:Abdominal Pain / Q000139:chemically induced* / Q000175:diagnosis* / Q000517:prevention & control; D000897:Anti-Ulcer Agents / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D000077402:Pantoprazole; D054328:Proton Pump Inhibitors / Q000009:adverse effects; D035583:Rare Diseases / Q000139:chemically induced / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D000077402:Pantoprazole