title: Interspecies transmission of canine influenza virus H5N2 to cats and chickens by close contact with experimentally infected dogs.
abstract: The novel H5N2 influenza virus, CA/SD/JT01/09, was isolated from the dog exhibiting respiratory signs in China in 2009. Dog to dog transmission of the novel H5N2 was previously confirmed. But interspecies transmission of the virus between dogs and the other animals has still remained unclear. To determine whether the virus can be transmitted directly from dogs to cats and chickens, we conducted contact exposure experiments. Susceptible cats and chickens were housed in the room which the novel H5N2 infected dogs were housed in, respectively. As a result, only one cat showed clear manifestations of H5N2 infection, but susceptibility of the other cats to H5N2 was confirmed by seroconversion. Eight of the exposure chickens showed clear manifestations of illness and 2 chickens died, and it demonstrates that chickens are susceptible to the recombinant H5N2. It implied that close contact between the H5N2-infected dogs and the cats and chickens resulted in spread of the virus to the sentinel animals.
authors.affiliation: Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Taian, Shandong 271018, China; College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong 271018, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Hai-xia
authors.affiliation: Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Taian, Shandong 271018, China; College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong 271018, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yuan-yuan
authors.affiliation: Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Taian, Shandong 271018, China; College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong 271018, China.
authors.forename: Song
authors.initials: S
authors.lastname: Qian-qian
authors.affiliation: Poultry Disease Lab of Shandong Entry-exit Inspection, Jinan, Shandong 250014, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zong-shuai
authors.affiliation: Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Taian, Shandong 271018, China; College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong 271018, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Feng-xia
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong 271018, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Yan-li
authors.affiliation: Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Taian, Shandong 271018, China; College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong 271018, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Shi-jin
authors.affiliation: Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Taian, Shandong 271018, China; College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong 271018, China. Electronic address: xiezhijing@126.com.
authors.forename: Xie
authors.initials: X
authors.lastname: Zhi-jing
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology / Q000635:transmission* / Q000821:virology*; D002415:Cats; D002645:Chickens; D002681:China; D004198:Disease Susceptibility; D004283:Dog Diseases / Q000473:pathology / Q000635:transmission / Q000821:virology*; D004285:Dogs; D058507:Host Specificity; D053125:Influenza A Virus, H5N2 Subtype / Q000502:physiology*; D009976:Orthomyxoviridae Infections / Q000473:pathology / Q000635:transmission / Q000662:veterinary* / Q000821:virology; D011201:Poultry Diseases / Q000473:pathology / Q000635:transmission / Q000821:virology*
keywords: Canine influenza virus; H5N2; Interspecies transmission