title: Kidney transplantation from donors with hepatitis C infection.
abstract: The increasing demand for organ donors to supply the increasing number of patients on kidney waiting lists has led to most transplant centers developing protocols that allow safe utilization from donors with special clinical situations which previously were regarded as contraindications. Deceased donors with previous hepatitis C infection may represent a safe resource to expand the donor pool. When allocated to serology-matched recipients, kidney transplantation from donors with hepatitis C may result in an excellent short-term outcome and a significant reduction of time on the waiting list. Special care must be dedicated to the pre-transplant evaluation of potential candidates, particularly with regard to liver functionality and evidence of liver histological damage, such as cirrhosis, that could be a contraindication to transplantation. Pre-transplant antiviral therapy could be useful to reduce the viral load and to improve the long-term results, which may be affected by the progression of liver disease in the recipients. An accurate selection of both donor and recipient is mandatory to achieve a satisfactory long-term outcome.
authors.affiliation: Massimiliano Veroux, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Burcin Ekser, Giuseppe Giuffrida, Pietro Caglià, Riccardo Gula, Vincenzo Ardita, Pierfrancesco Veroux, Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Veroux
authors.affiliation: Massimiliano Veroux, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Burcin Ekser, Giuseppe Giuffrida, Pietro Caglià, Riccardo Gula, Vincenzo Ardita, Pierfrancesco Veroux, Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Corona
authors.affiliation: Massimiliano Veroux, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Burcin Ekser, Giuseppe Giuffrida, Pietro Caglià, Riccardo Gula, Vincenzo Ardita, Pierfrancesco Veroux, Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.
authors.forename: Nunziata
authors.initials: N
authors.lastname: Sinagra
authors.affiliation: Massimiliano Veroux, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Burcin Ekser, Giuseppe Giuffrida, Pietro Caglià, Riccardo Gula, Vincenzo Ardita, Pierfrancesco Veroux, Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Giaquinta
authors.affiliation: Massimiliano Veroux, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Burcin Ekser, Giuseppe Giuffrida, Pietro Caglià, Riccardo Gula, Vincenzo Ardita, Pierfrancesco Veroux, Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Zerbo
authors.affiliation: Massimiliano Veroux, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Burcin Ekser, Giuseppe Giuffrida, Pietro Caglià, Riccardo Gula, Vincenzo Ardita, Pierfrancesco Veroux, Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.
authors.forename: Burcin
authors.initials: B
authors.lastname: Ekser
authors.affiliation: Massimiliano Veroux, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Burcin Ekser, Giuseppe Giuffrida, Pietro Caglià, Riccardo Gula, Vincenzo Ardita, Pierfrancesco Veroux, Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Giuffrida
authors.affiliation: Massimiliano Veroux, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Burcin Ekser, Giuseppe Giuffrida, Pietro Caglià, Riccardo Gula, Vincenzo Ardita, Pierfrancesco Veroux, Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Caglià
authors.affiliation: Massimiliano Veroux, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Burcin Ekser, Giuseppe Giuffrida, Pietro Caglià, Riccardo Gula, Vincenzo Ardita, Pierfrancesco Veroux, Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Gula
authors.affiliation: Massimiliano Veroux, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Burcin Ekser, Giuseppe Giuffrida, Pietro Caglià, Riccardo Gula, Vincenzo Ardita, Pierfrancesco Veroux, Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Ardita
authors.affiliation: Massimiliano Veroux, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Burcin Ekser, Giuseppe Giuffrida, Pietro Caglià, Riccardo Gula, Vincenzo Ardita, Pierfrancesco Veroux, Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Veroux
mesh_terms: D005921:Glomerulonephritis / Q000821:virology; D006526:Hepatitis C / Q000150:complications / Q000628:therapy; D006801:Humans; D016030:Kidney Transplantation; D011300:Preoperative Care; D014019:Tissue Donors
keywords: De novo glomerulonephritis; Deceased donor; End-stage renal disease; Graft survival; Hemodialysis; Hepatitis C virus; Kidney transplantation; Liver failure