title: Successful use of intensive immunosuppressive therapy for treating simultaneously occurring cerebral lesions and pulmonary arterial hypertension in a patient with systemic lupus erythematosus.
abstract: A 59-year-old woman who had been diagnosed with systemic lupus erythematosus (SLE) was admitted to our hospital due to paralysis in all of her limbs. The patient presented with dysarthria, cerebellar ataxia and hypoxia. Magnetic resonance imaging (MRI) revealed vasogenic edema in the brain stem and the cerebellum. She was diagnosed with neuropsychiatric lupus syndrome (NPSLE) and pulmonary arterial hypertension (PAH), and was successfully treated using immunosuppressive therapy. To our knowledge, this is the first reported case of simultaneously developing NPSLE and PAH.
authors.affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Japan.
authors.forename: Ryu
authors.initials: R
authors.lastname: Watanabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujii
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shirai
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Saito
authors.forename: Akira
authors.initials: A
authors.lastname: Hatakeyama
authors.forename: Koichiro
authors.initials: K
authors.lastname: Sugimura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fukumoto
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ishii
authors.forename: Hideo
authors.initials: H
authors.lastname: Harigae
mesh_terms: D001933:Brain Stem / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology*; D004487:Edema / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents