title: The usual suspects in sudden cardiac death of the young: a focus on inherited arrhythmogenic diseases.
abstract: Up to 14,500 young individuals die suddenly every year in Europe of cardiac pathologies. The majority of these tragic events are related to a group of genetic defects that predispose the development of malignant arrhythmias (inherited arrhythmogenic diseases [IADs]). IADs include both cardiomyopathies (hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy) and channelopathies (long QT syndrome, short QT syndrome, Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia). Every time an IAD is identified in a patient, other individuals in his/her family may be at risk of cardiac events. However; if a timely diagnosis is made, simple preventative measures may be applied. Genetic studies play a pivotal role in the diagnosis of IADs and may help in the management of patients and their relatives.
authors.affiliation: Molecular Cardiology, IRCCS Salvatore Maugeri Foundation, Pavia, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Mazzanti
authors.forename: Sean
authors.initials: S
authors.lastname: O'Rourke
authors.forename: Kevin
authors.initials: K
authors.lastname: Ng
authors.forename: Carlotta
authors.initials: C
authors.lastname: Miceli
authors.forename: Gianluca
authors.initials: G
authors.lastname: Borio
authors.forename: Antonio
authors.initials: A
authors.lastname: Curcio
authors.forename: Francesca
authors.initials: F
authors.lastname: Esposito
authors.forename: Carlo
authors.initials: C
authors.lastname: Napolitano
authors.forename: Silvia G
authors.initials: SG
authors.lastname: Priori
mesh_terms: D001145:Arrhythmias, Cardiac / Q000150:complications / Q000175:diagnosis* / Q000517:prevention & control; D053840:Brugada Syndrome / Q000175:diagnosis* / Q000235:genetics / Q000517:prevention & control; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D016757:Death, Sudden, Cardiac / Q000209:etiology* / Q000517:prevention & control; D003937:Diagnosis, Differential; D004198:Disease Susceptibility; D006801:Humans; D017180:Tachycardia, Ventricular / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000517:prevention & control; D000098850:Polymorphic Catecholaminergic Ventricular Tachycardia