title: Jugular bulb abnormalities in patients with Meniere's disease using high-resolution computed tomography.
abstract: Temporal bone abnormalities such as hypoplasia of the vestibular aqueduct or hypopneumatization of the mastoid have been described in Meniere's disease (MD). Jugular bulb abnormalities (JBA) are one of the most common temporal bone abnormalities. The aim of this study was to evaluate the frequency of JBA in MD. Radiological data obtained by temporal bone high-resolution computed tomography of 200 ears of 167 MD patients (MD group) and 218 ears of 109 patients with normal inner ear function (control group) were analyzed retrospectively. The frequencies of high jugular bulb (HJB), jugular bulb diverticulum (JBD), inner ear adjacent jugular bulb (IAJB) and jugular bulb related inner ear dehiscence (JBID) were evaluated and compared between MD group and control group. IAJB was differentiated into vestibular aqueduct adjacent jugular bulb (VAAJB), cochlear aqueduct adjacent jugular bulb and posterior semicircular canal adjacent jugular bulb. JBID was further analyzed by differentiating into jugular bulb related vestibular aqueduct dehiscence (JBVAD), jugular bulb related cochlear aqueduct dehiscence and jugular bulb related posterior semicircular canal dehiscence. The frequencies of HJB, JBD and IAJB were higher in MD group compared to control group (21, 13.3 %, p = 0.036; 8.5, 3.7 %, p = 0.037; 13.5, 4.6 %, p = 0.001). No differences between both groups were seen in JBID (4.0, 2.3 %, p = 0.315). Most IAJB and JBID were seen in VAAJB and JBVAD. There is a higher frequency of JBA in patients with MD than in patients without inner ear symptoms. Temporal bones of MD patients might be constituted anatomically different, carrying predisposing factors for the development of clinically apparent MD.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany, jpark@ukaachen.de.
authors.forename: Jonas J-H
authors.initials: JJ
authors.lastname: Park
authors.forename: Anmin
authors.initials: A
authors.lastname: Shen
authors.forename: Sebastian
authors.initials: S
authors.lastname: Keil
authors.forename: Christiane
authors.initials: C
authors.lastname: Kuhl
authors.forename: Martin
authors.initials: M
authors.lastname: Westhofen
mesh_terms: D003052:Cochlear Aqueduct / Q000000981:diagnostic imaging; D004240:Diverticulum; D005260:Female; D006801:Humans; D007601:Jugular Veins / Q000002:abnormalities / Q000000981:diagnostic imaging; D008297:Male; D008416:Mastoid / Q000000981:diagnostic imaging; D008575:Meniere Disease / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012665:Semicircular Canals / Q000000981:diagnostic imaging; D013701:Temporal Bone / Q000002:abnormalities / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods; D014723:Vestibular Aqueduct / Q000000981:diagnostic imaging