title: Molecular blood grouping of donors.
abstract: For many decades, hemagglutination has been the sole means to type blood donors. Since the first blood group gene cloning in the early 1990s, knowledge on the molecular basis of most red blood cell, platelet and neutrophil antigens brought the possibility of using nucleotide-based techniques to predict phenotype. This review will summarized methodologies available to genotype blood groups from laboratory developed assays to commercially available platforms, and how proficiency assays become more present. The author will also share her vision of the transfusion medicine future. The field is presently at the crossroads, bringing new perspectives to a century old practice.
authors.affiliation: Recherche et développement, Héma-Québec, Québec, Québec, Canada. Electronic address: Maryse.St-Louis@hema-quebec.qc.ca.
authors.forename: Maryse
authors.initials: M
authors.lastname: St-Louis
mesh_terms: D001782:Blood Donors; D001788:Blood Grouping and Crossmatching / Q000379:methods*; D046148:Donor Selection / Q000379:methods*; D005260:Female; D005838:Genotype; D060005:Genotyping Techniques / Q000379:methods*; D006801:Humans; D008297:Male
keywords: Alloimmunization; Antigen-negative inventory; Assay development; Donors; Drymatching; Genotyping; Platforms