title: Association Between p21 Ser31Arg Polymorphism and Gastrointestinal Tract Tumor Risk: A Meta-analysis.
abstract: Human p21 gene is characterized by a polymorphism at codon 31 leading to a Serine-to- Arginine (S/R), two different alleles of p21 Ser31Arg (rs 1801270) polymorphism have been shown to differ significantly in their transcriptional efficiency. More and more investigations are now being carried out to examine a possible link between the p21 Ser31Arg polymorphism and cancer. However, the results were inconclusive. Therefore, we carried out a systematic review and meta-analysis to examine whether this polymorphism is associated with gastrointestinal tract tumor in Asian. Seven studies (n = 2690), comprising 967 cases and 1723 controls in Asian population, were included in our study. The meta-analysis showed significant association between Ser-allele or Ser/Ser genotype and the susceptibility to gastrointestinal tract tumor in overall studies (Ser-allele vs. Arg-allele: OR = 1.17, 95% CI: 1.04-1.31; Ser/Ser vs. Arg/Arg: OR = 1.38, 95% CI: 1.09-1.75; Ser/Ser vs. Arg/Ser: OR = 1.27, 95% CI: 1.05-1.53; Ser/Ser vs. Arg/Ser + Arg/Arg: OR = 1.29, 95% CI: 1.07-1.54). Despite the limitations, the results of the present meta-analysis suggested that, in the p21 Ser31Arg polymorphism, Ser-allele and Ser/Ser genotype might be risk factors for gastrointestinal tract tumor in Asian populations.
authors.affiliation: Key Laboratory of Reproduction and Heredity of Ningxia Region Ying Dong and Xiaohua Wang contribute equally to this article.
authors.forename: Ying
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Key Laboratory of Reproduction and Heredity of Ningxia Region Ying Dong and Xiaohua Wang contribute equally to this article.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Wang
authors.affiliation: Oncology Department of Cancer Hospital & Institute, General Hospital.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Ye
authors.affiliation: Key Laboratory of Reproduction and Heredity of Ningxia Region Oncology Department of Cancer Hospital & Institute, General Hospital.
authors.forename: Guanhua
authors.initials: G
authors.lastname: Wang
authors.affiliation: Key Laboratory of Reproduction and Heredity of Ningxia Region Radiology Department of General Hospital.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Oncology Department of Cancer Hospital & Institute, General Hospital.
authors.forename: Ningju
authors.initials: N
authors.lastname: Wang
authors.affiliation: Surgical Laboratory of General Hospital, Ningxia Medical University, Yinchuan, Ningxia, 750004, P. R. China.
authors.forename: Yinxue
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Radiology Department of General Hospital yw001@nxmu.edu.cn czq642000@163.com.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Key Laboratory of Reproduction and Heredity of Ningxia Region Oncology Department of Cancer Hospital & Institute, General Hospital yw001@nxmu.edu.cn czq642000@163.com.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Yang
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D044466:Asian People / Q000235:genetics; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21
keywords: Asian; Codon 31; Gastrointestinal tract tumor; Meta analysis; p21.