title: Disseminated Nocardia paucivorans infection in an immunocompetent host.
abstract: Nocardia paucivorans is a recently discovered species that has been shown to have a predilection for CNS involvement in cases of disseminated infection. We present a 50-year-old man with one year of weight loss admitted to the hospital with cough and confusion. Imaging revealed pulmonary and iliopsoas masses as well as innumerable ring-enhancing brain lesions. N. paucivorans was eventually identified in a subcarinal lymph node biopsy. The diagnosis was expedited by utilizing 16s rRNA gene sequencing on the biopsy tissue, resulting in species-level identification several weeks prior to culture positivity. He was treated with 12 months of parenteral and oral antibiotics, with resolution of pulmonary and brain lesions on repeat imaging.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, 3211 Taubman Center, 1500 E. Medical Center Dr., SPC 5378, Ann Arbor, MI, 48109-5378, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hammoud
authors.forename: C
authors.initials: C
authors.lastname: Kraft
authors.forename: J
authors.initials: J
authors.lastname: Pulst-Korenberg
authors.forename: C
authors.initials: C
authors.lastname: Chenoweth
authors.forename: K S
authors.initials: KS
authors.lastname: Gregg
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008824:Michigan; D009615:Nocardia / Q000235:genetics / Q000302:isolation & purification*; D009617:Nocardia Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D012336:RNA, Ribosomal, 16S