title: Frontal sinus obliteration after trauma: analysis of bone regeneration for two selected methods.
abstract: We present a prospective randomized experimental study comparing bone regeneration obtained in 60 post-traumatic frontal sinuses obliterated with either calvarial bone dust (n=30, group I) or calvarial bone and demineralized bone matrix (DBM; n=30, group II). Radiological follow-up included high-resolution computed tomography with quantitative micro-density analysis in Hounsfield units (HU), together with a volumetric evaluation of the ossification at 6 and 24 months after surgical treatment. Epidemiological information and potential drawbacks were analysed. Bone volume and density data (HU) for the regenerated areas were subjected to statistical analysis at 6 and 24 months for both groups. Results were compared with reference values obtained from frontal and temporal bone in every patient. Complications developed for 10% of operated sinuses. The resulting bone formation (HU) in group I patients was significantly better than that obtained in group II. Ossification progressed in a statistically significant manner in both groups when compared at 6 and 24 months postoperatively. The use of DBM as a biomaterial associated with calvarial bone dust for sinus obliteration shows long-term safe results, similar to autogenous bone, but with a lower final bone density.
authors.affiliation: Oral and Maxillofacial Surgery Department, 12 de Octubre University Hospital, Madrid, Spain. Electronic address: ignaciozubillaga@yahoo.es.
authors.forename: I
authors.initials: I
authors.lastname: Zubillaga Rodríguez
authors.affiliation: Clinic Research Department, IMAS12-CIBERESP, 12 de Octubre University Hospital, Madrid, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Lora Pablos
authors.affiliation: Oral and Maxillofacial Surgery Department, 12 de Octubre University Hospital, Madrid, Spain.
authors.forename: M I
authors.initials: MI
authors.lastname: Falguera Uceda
authors.affiliation: Neurosurgery Department, 12 de Octubre University Hospital, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Díez Lobato
authors.affiliation: Oral and Maxillofacial Surgery Department, 12 de Octubre University Hospital, Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Sánchez Aniceto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D015519:Bone Density; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration; D016025:Bone Transplantation / Q000379:methods*; D005260:Female; D005626:Frontal Sinus / Q000000981:diagnostic imaging / Q000293:injuries* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D001672:Biocompatible Materials
keywords: Hounsfield units (HU); calvarial bone dust; demineralized bone matrix (DBM); frontal sinus; subcranial approach