title: Phomopsolides and related compounds from the alga-associated fungus, Penicillium clavigerum.
abstract: For the past fifteen years we have studied the secondary metabolites of extremophilic fungi from the Berkeley Pit, an abandoned acid mine waste lake. Fungi associated with an acid-tolerant alga have also been harvested from the Pit. Penicillium clavigerum Demelius was isolated from the green alga Chlorella vulgaris Beyerinck [Beijerinck]. In culture it produced the known compounds phomfuranone (1), patulin (2), dimethylphthalides (3) and (4), phomopsolide A (5), phomopsolide C (6), phomopsolide B (7), phomopsolide E (8), phomopsolide F (9), and phompyrone (10) and the new compound berkbenzofuran thioester (11). Compounds 5 and 6 were potent inhibitors (IC50 < 10 microM) of specific and established human cancer cell lines.
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Stierle
authors.forename: Donald B
authors.initials: DB
authors.lastname: Stierle
authors.forename: Grant G
authors.initials: GG
authors.lastname: Mitman
authors.forename: Shea
authors.initials: S
authors.lastname: Snyder
authors.forename: Christophe
authors.initials: C
authors.lastname: Antczak
authors.forename: Hakim
authors.initials: H
authors.lastname: Djaballah
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification*; D001572:Benzofurans / Q000302:isolation & purification; D048408:Chlorella vulgaris / Q000382:microbiology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D010407:Penicillium / Q000737:chemistry*; D011753:Pyrones / Q000302:isolation & purification*
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; D011753:Pyrones; C587832:berkbenzofuran thioester; C109951:phomopsolide A; C512390:phomopsolide C