title: Matrix Metalloprotienases and its inhibitors: An insight.
abstract: Periodontal disease progression involves degradation of the collagenous matrix by a group of enzymes known as the matrix metalloprotienases. These matrix metalloprotienases are secreted by the polymorphonuclear leukocytes, macrophages, fibroblasts, bone, epithelial and endothelial cells. These molecules have involvement in both physiological and pathological processes. It is shown that periodontal disease occurs when there is an imbalance between the activated metalloprotienases and their endogenous inhibitors. These can be modified by exogenous inhibitors like bisphosphonates, tetracyclines, etc. How to cite the article: Kumar P, Kumar L, Murthy S, Gurudath G. Matrix Metalloprotienases and its inhibitors: An insight. J Int Oral Health 2014;6(1):127-9.
authors.affiliation: Department of Periodontics, AJ Shetty Dental Hospital, Mangalore, Karnataka, India.
authors.forename: Parimala
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Department of Oral & Maxillofacial Surgery,AJ Shetty Dental Hospital, Mangalore, Karnataka, India.
authors.forename: Laxmish
authors.initials: L
authors.lastname: Kumar
authors.affiliation: Department of Prosthodontics & Crown & Bridge, A J Institute of Dental Sciences, Mangalore, Karnataka, India.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Murthy
authors.affiliation: Department of Public Health Dentistry, A J Institute of Dental Sciences, Mangalore, Karnataka, India.
authors.forename: G
authors.initials: G
authors.lastname: Gurudath
keywords: Collagenous matrix; matrix metalloprotienases; periodontal diseases