title: Association between sleep disordered breathing and aggressiveness markers of malignant cutaneous melanoma.
abstract: Some recent studies have shown an association between sleep disordered breathing (SDB) and cancer mortality and incidence but no study has focused on a specific type of cancer. The objective of this study was to analyse the relationship between the severity of SDB and factors related to cutaneous malignant melanoma (CMM) aggressiveness. We performed a multicentre observational study in 82 consecutive patients diagnosed with CMM. 56 patients in whom melanoma measurements were available were finally included in the study. Melanoma measurements of aggressiveness included: tumour mitotic rate, Breslow index, presence of ulceration, stage of disease and growth rate of melanoma. A sleep study was performed in all the included patients. Multivariate analyses were used to examine the independent relationship between SDB severity (apnoea-hypopnea index (AHI) and nocturnal oxygen desaturation indexes (ODI3% and ODI4%)) and measures of CMM aggressiveness. 60.7% of patients had SDB (AHI ≥ 5) and 14.3% severe obstructive sleep apnoea (AHI ≥ 30). In fully adjusted multivariate analyses, AHI (OR 1.08, 95% CI 1.02-1.14), ODI3% (OR 1.08, 95% CI 1.02-1.11) and ODI4% (OR 1.1, 95% CI 1.02-1.2) were independently associated with an increased melanoma growth rate. Furthermore, AHI, ODI4% and ODI3% were significantly correlated with other aggressiveness factors of CMM, such as Breslow index, presence of ulceration and mitotic index. SDB severity markers are associated with some aggressiveness markers of CMM.
authors.affiliation: Servicio de Neumología, Hospital Universitario y Politécnico La Fe, Valencia CIBER de Enfermedades Respiratorias, Bunyoles mianmartinezgarcia@gmail.com.
authors.forename: Miguel-Ángel
authors.initials: MÁ
authors.lastname: Martínez-García
authors.affiliation: Servicio de Dermatología, Hospital de Manises, Valencia.
authors.forename: Antonio
authors.initials: A
authors.lastname: Martorell-Calatayud
authors.affiliation: Instituto Valenciano de Oncología, Valencia Facultad de Medicina, Universidad Católica de Valencia "San Vicente Martir", Valencia.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Nagore
authors.affiliation: Servicio de Neumología, Hospital Universitario y Politécnico La Fe, Valencia.
authors.forename: Irene
authors.initials: I
authors.lastname: Valero
authors.affiliation: Servicio de Neumología, Hospital Universitario y Politécnico La Fe, Valencia.
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Selma
authors.affiliation: Servicio de Neumología, Hospital Universitario San Juan, Alicante.
authors.forename: Eusebi
authors.initials: E
authors.lastname: Chiner
authors.affiliation: Servicio de Neumología, Hospital Universitario San Juan, Alicante.
authors.forename: Pedro
authors.initials: P
authors.lastname: Landete
authors.affiliation: CIBER de Enfermedades Respiratorias, Bunyoles Servicios de Neumología y Dermatología, IDIBAPs Hospital Clinic, Barcelona.
authors.forename: Josep-Maria
authors.initials: JM
authors.lastname: Montserrat
authors.affiliation: Servicios de Neumología y Dermatología, IDIBAPs Hospital Clinic, Barcelona.
authors.forename: Cristina
authors.initials: C
authors.lastname: Carrera
authors.affiliation: Servicios de Neumología y Dermatología, Hospital Valme, Seville.
authors.forename: Amalia
authors.initials: A
authors.lastname: Pérez-Gil
authors.affiliation: Servicios de Neumología y Dermatología, Hospital Valme, Seville.
authors.forename: Francisco
authors.initials: F
authors.lastname: Campos-Rodríguez
authors.affiliation: CIBER de Enfermedades Respiratorias, Bunyoles Universidad de Barcelona-IDIBAPS, Barcelona, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: Farré
mesh_terms: D000328:Adult; D000368:Aged; D045422:Continuous Positive Airway Pressure / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D010100:Oxygen / Q000737:chemistry; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D017286:Polysomnography; D012878:Skin Neoplasms / Q000150:complications* / Q000175:diagnosis; D012890:Sleep; D012891:Sleep Apnea Syndromes / Q000150:complications*; D016896:Treatment Outcome; D000096142:Cutaneous Malignant Melanoma
chemical_list: D010100:Oxygen