title: Tissue biomarkers for prognosis of prostate cancer: a systematic review and meta-analysis.
abstract: BACKGROUND
  Although numerous investigators have made efforts to assess prognostic biomarkers of prostate cancer, no biomarker has been recommended for clinical practice.
  
  
  METHODS
  According to REMARK (Reporting recommendations for tumor marker prognostic studies) and MISFISHIE (Minimum information specification for in situ hybridization and immunohistochemistry experiments) guidelines, the published articles of immunohistochemistry-based prognostic biomarkers on prostate cancer were extracted and pooled.
  
  
  RESULTS
  Ninety-three prognostic biomarkers from 92 high-quality cohort studies were included in this meta-analysis. Our analysis reveals some promising independent prognostic biomarkers, including Ki-67 [all-cause mortality (ACM) HR, 1.85; 95% confidence interval (CI), 1.06-3.25; PSM HR, 1.82; 95% CI, 1.42-2.34; DFS HR, 1.51; 95% CI, 1.31-1.75]; Bcl-2 (ACM HR, 2.14; 95% CI, 1.27-3.58; PSM HR, 1.61; 95% CI, 1.01-2.57; DFS HR, 3.86; 95% CI, 2.14-6.96); CD147 (ACM HR, 2.63; 95% CI, 1.19-5.81; DFS HR, 5.84; 95% CI, 3.41-9.99); COX-2 (PSM HR, 7.6; 95% CI, 0.7-80.1; DFS HR, 7.9; 95% CI, 2.62-23.83); ALDH1A1 (ACM HR, 1.73; 95% CI, 1.163-2.527; PSM HR, 1.05; 95% CI, 1.028-1.107), and FVIII (ACM HR, 1.76; 95% CI, 1.19-2.60; PSM HR, 1.01; 95% CI, 1.01-1.02).
  
  
  CONCLUSIONS
  Our analysis identified a subset of biomarkers (Ki-67, Bcl-2, CD147, COX-2, ALDH1A1, and FVIII) that may have prognostic value for predicting the outcome of patients with prostate cancer.
  
  
  CONCLUSIONS
  These reliable prognostic biomarkers will improve the clinical management of patients with prostate cancer. Cancer Epidemiol Biomarkers Prev; 23(6); 1047-54. ©2014 AACR.
authors.affiliation: Authors' Affiliations: Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education; and Experimental Teaching Center of Basic Medicine Science, Chongqing Medical University, Chongqing, China.
authors.forename: Liuyang
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Authors' Affiliations: Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education; and Experimental Teaching Center of Basic Medicine Science, Chongqing Medical University, Chongqing, China.
authors.forename: Na
authors.initials: N
authors.lastname: Yu
authors.affiliation: Authors' Affiliations: Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education; and Experimental Teaching Center of Basic Medicine Science, Chongqing Medical University, Chongqing, China.
authors.forename: Tianfang
authors.initials: T
authors.lastname: Guo
authors.affiliation: Authors' Affiliations: Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education; and Experimental Teaching Center of Basic Medicine Science, Chongqing Medical University, Chongqing, ChinaAuthors' Affiliations: Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education; and Experimental Teaching Center of Basic Medicine Science, Chongqing Medical University, Chongqing, China.
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Authors' Affiliations: Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education; and Experimental Teaching Center of Basic Medicine Science, Chongqing Medical University, Chongqing, China.
authors.forename: Zongyue
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Authors' Affiliations: Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education; and Experimental Teaching Center of Basic Medicine Science, Chongqing Medical University, Chongqing, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Yang
authors.affiliation: Authors' Affiliations: Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education; and Experimental Teaching Center of Basic Medicine Science, Chongqing Medical University, Chongqing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Hu
authors.affiliation: Authors' Affiliations: Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education; and Experimental Teaching Center of Basic Medicine Science, Chongqing Medical University, Chongqing, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Tang
authors.affiliation: Authors' Affiliations: Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education; and Experimental Teaching Center of Basic Medicine Science, Chongqing Medical University, Chongqing, China martinliu12345@gmail.com wxy890729@qq.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Authors' Affiliations: Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education; and Experimental Teaching Center of Basic Medicine Science, Chongqing Medical University, Chongqing, China martinliu12345@gmail.com wxy890729@qq.com.
authors.forename: Manran
authors.initials: M
authors.lastname: Liu
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000737:chemistry* / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor