title: [Frontal variant of frontotemporal dementia].
abstract: The behavioral variant of frontotemporal dementia (bvFTD), characterized by early behavioral disorders, is a rare disease (about 5.000 cases in France). Diagnostic criteria have been revised in 2011 and propose three levels of diagnostic probability. However, it still could be difficult to discriminate FTD from other cerebral affections or psychiatric diseases. Genetic and molecular research has greatly expanded during the past fifteen years. About ten mutations have been discovered, bringing to describe particular phenotypes. To date, there is no curative treatment. Memantine had aroused some hope but is now abandoned. Inhibitors of serotonine recapture often permit to temporarily reduce behavioral troubles. But the caregiver's burden is high. The evolution of the bvFTD is faster than that of AD, particularly when associated with motor neuron disease (15% of cases). The therapeutic hope relies today on potential disease modifying drugs which could ensue from genetic discoveries.
authors.affiliation: Centre mémoire ressources et recherche, Hôpital Laennec, CHU de Nantes, France ; Labo EMC, EA3082, Université Lyon 2, Bron, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Boutoleau-Bretonniere
authors.affiliation: Centre mémoire ressources et recherche, Hôpital Laennec, CHU de Nantes, France ; Labo EMC, EA3082, Université Lyon 2, Bron, France.
authors.forename: Thibaud
authors.initials: T
authors.lastname: Lebouvier
authors.affiliation: Centre mémoire ressources et recherche, Hôpital Laennec, CHU de Nantes, France ; Labo EMC, EA3082, Université Lyon 2, Bron, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Vercelletto
mesh_terms: D000368:Aged; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D003704:Dementia / Q000175:diagnosis; D018450:Disease Progression; D005602:France / Q000453:epidemiology; D057180:Frontotemporal Dementia / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology*; D006801:Humans; D015994:Incidence; D008559:Memantine / Q000627:therapeutic use; D009483:Neuropsychological Tests; D015995:Prevalence
chemical_list: D002800:Cholinesterase Inhibitors; D008559:Memantine
keywords: behavioral scales; behavioral symptoms; diagnostic criteria; frontotemporal dementia; genetic