title: [Postoperative radiation therapy for a patient with osteogenesis imperfecta: case report].
abstract: Osteogenesis imperfecta is an unusual disease also called Lobstein disease. Characterized by abnormalities of collagen biosynthesis, a possible mutation on 17th chromosome is described. On the other hand, 29% of breast cancers present a mutation on the same chromosome. Nevertheless, the association of osteogenesis imperfecta and breast cancer is at the moment unknown. Therapeutic management is very difficult because of a loss in dihydropyrimidine dehydrogenase for patients having osteogenesis imperfecta, generating some toxicity by default in catabolism of 5-fluorouracil. We report the case of a 49-year-old woman with a breast cancer in the context of osteogenesis imperfecta. Dosimetric considerations permitting to reduce chess dose level have been performed for this patient. With a follow-up of 6 months, no imaging fracture has been revealed after radiotherapy. No evident conclusion about radiation injury from a case report could be described in case of osteogenesis imperfecta. To our knowledge, this is the first case which take into account potential radiation induced toxicities.
authors.affiliation: Département de radiothérapie, institut Bergonié, centre régional de lutte contre le cancer, 229, cours de l'Argonne, 33076 Bordeaux cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Ducournau
authors.affiliation: Département de radiothérapie, institut Bergonié, centre régional de lutte contre le cancer, 229, cours de l'Argonne, 33076 Bordeaux cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Lagarde
authors.affiliation: Département de radiothérapie, institut Bergonié, centre régional de lutte contre le cancer, 229, cours de l'Argonne, 33076 Bordeaux cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Henriques de Figueiredo
authors.affiliation: Unité de physique médicale, institut Bergonié, centre régional de lutte contre le cancer, 229, cours de l'Argonne, 33076 Bordeaux cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Antoine
authors.affiliation: Département de radiothérapie, institut Bergonié, centre régional de lutte contre le cancer, 229, cours de l'Argonne, 33076 Bordeaux cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Breton-Callu
authors.affiliation: Département de radiothérapie, institut Bergonié, centre régional de lutte contre le cancer, 229, cours de l'Argonne, 33076 Bordeaux cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Petit
authors.affiliation: Département d'imagerie médicale, CHU Bichat-Claude-Bernard, 46, rue Henri-Huchard, 75018 Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Dallaudière
authors.affiliation: Département de radiothérapie, institut Bergonié, centre régional de lutte contre le cancer, 229, cours de l'Argonne, 33076 Bordeaux cedex, France. Electronic address: p.sargos@bordeaux.unicancer.fr.
authors.forename: P
authors.initials: P
authors.lastname: Sargos
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism / Q000532:radiotherapy* / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000532:radiotherapy* / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology / Q000601:surgery; D010013:Osteogenesis Imperfecta / Q000150:complications*; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
keywords: Breast neoplasm; Cancer du sein; Chemotherapy; Chimiothérapie; Lobstein disease; Maladie de Lobstein; Osteogenesis imperfecta; Ostéogenèse imparfaite; Radiation therapy; Radiothérapie