title: Fat mass gain predicts estimated GFR decline in a relatively healthy Korean population.
abstract: BACKGROUND
  Previous studies have shown that obesity is a risk factor for estimated glomerular filtration rate (eGFR) decline and chronic kidney disease (CKD). However, the relationship between fat mass directly measured by bioimpedance analysis and eGFR is not well known.
  
  
  METHODS
  We analyzed 21,859 participants without CKD at baseline who underwent two health checkups at a 5-year interval during 2002-2009. Fat mass was measured by Inbody 3.0 (Biospace, Seoul, Korea). eGFR decline was defined as eGFR <60 ml/min/1.73 m(2) at second checkup. Logistic regression analysis was used to analyze factors related to eGFR decline.
  
  
  RESULTS
  Participants were divided into tertiles according to their fat mass change over 5 years: lower tertile (n = 7,042; <-0.7 kg), middle tertile (n = 7,478; -0.7 to 1.2 kg) and higher tertile (n = 7,339; >1.2 kg). After 5 years, 246 cases of eGFR decline were observed. Multivariate logistic analysis revealed that age (OR 1.03, 95% CI 1.02-1.05, p < 0.001), diabetes mellitus (OR 2.04, 95% CI 1.22-3.40, p = 0.007), baseline eGFR (OR 0.80, 95% CI 0.78-0.83, p < 0.001) and higher tertile of fat mass change (OR 1.58, 95% CI 1.16-2.13, p = 0.003) were associated with eGFR decline after adjustment for sex, hypertension, dyslipidemia, cardiovascular disease, smoking status, body mass index, and high-density lipoprotein cholesterol level.
  
  
  CONCLUSIONS
  Fat mass gain over 5 years was independently associated with eGFR decline to <60 ml/min/1.73 m(2) in a relatively healthy Korean population. This finding suggests that lifestyle changes to prevent fat mass gain could be protective against the development of CKD.
authors.affiliation: Department of Internal Medicine, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Republic of Korea.
authors.forename: Young Youl
authors.initials: YY
authors.lastname: Hyun
authors.forename: Hyang
authors.initials: H
authors.lastname: Kim
authors.forename: Kyu Beck
authors.initials: KB
authors.lastname: Lee
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000328:Adult; D000367:Age Factors; D003920:Diabetes Mellitus / Q000503:physiopathology; D017097:Electric Impedance; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D056910:Republic of Korea; D012189:Retrospective Studies