title: A 3-fold-symmetric ligand based on 2-hydroxypyridine: regulation of ligand binding by hydrogen bonding.
abstract: A tripodal ligand based on 2-hydroxypyridine is presented. Cu-Cl adducts of H3thpa with Cu(I) and Cu(II) provide complexes featuring highly directed, intramolecular hydrogen-bonding interactions. An upper limit for the hydrogen-bonding free energy to Cu(I)-Cl was estimated at ∼18 kcal/mol.
authors.affiliation: Department of Chemistry, University of Michigan , Ann Arbor, Michigan 48109, United States.
authors.forename: Cameron M
authors.initials: CM
authors.lastname: Moore
authors.forename: David A
authors.initials: DA
authors.lastname: Quist
authors.forename: Jeff W
authors.initials: JW
authors.lastname: Kampf
authors.forename: Nathaniel K
authors.initials: NK
authors.lastname: Szymczak
mesh_terms: D003300:Copper / Q000737:chemistry; D006860:Hydrogen Bonding / Q000187:drug effects; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D011728:Pyridones / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D008024:Ligands; D011728:Pyridones; C017679:2-hydroxypyridine; D003300:Copper