title: [Study on association of FABP2 gene Ala54Thr polymorphism with risk of obesity, body fat mass and physical activity].
abstract: Obesity is a multifactorial disease which depends on the interaction between genome and environment. Fatty acid-binding protein 2 (FABP2) regulates lipid transport, intestinal absorption and metabolism. The aim of the study was to investigate the interrelation between the FABP2 gene Ala54Thr polymorphism, body mass index and body fat mass and to study distribution of genotypes and alleles frequencies of FABP2 gene in athletes and individuals who are not involved in sports. 315 athletes of different sport disciplines and levels and 612 controls (predominantly students) participated in the study. Genotyping for the FABP2 gene Ala54Thr polymorphism was performed by PCR. Body composition was analyzed by bioimpedance method. The study did not confirm the association of FABP2 gene Ala54Thr polymorphism with the risk of obesity and body fat mass. However, the frequency of the Thr54 allele was significantly higher in elite stayers (50.0%, p = 0.025) and combat athletes (46.2%, p = 0.013) in comparison with controls (32.2%). Thus, FABP2 gene Ala54Thr polymorphism is associated with the predisposition to endurance athletic performance.
authors.forename: É S
authors.initials: ÉS
authors.lastname: Nasibulina
authors.forename: A V
authors.initials: AV
authors.lastname: Borisova
authors.forename: I I
authors.initials: II
authors.lastname: Akhmetov
mesh_terms: D000273:Adipose Tissue / Q000502:physiology* / Q000503:physiopathology; D000328:Adult; D054458:Amplified Fragment Length Polymorphism Analysis; D001823:Body Composition; D015992:Body Mass Index; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics* / Q000503:physiopathology; D010807:Physical Endurance / Q000235:genetics* / Q000502:physiology; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D013177:Sports; D055815:Young Adult
chemical_list: C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins