title: Rewiring cell polarity signaling in cancer.
abstract: Disrupted cell polarity is a feature of epithelial cancers. The Crumbs, Par and Scribble polarity complexes function to specify and maintain apical and basolateral membrane domains, which are essential to organize intracellular signaling pathways that maintain epithelial homeostasis. Disruption of apical-basal polarity proteins facilitates rewiring of oncogene and tumor suppressor signaling pathways to deregulate proliferation, apoptosis, invasion and metastasis. Moreover, apical-basal polarity integrates intracellular signaling with the microenvironment by regulating metabolic signaling, extracellular matrix remodeling and tissue level organization. In this review, we discuss recent advances in our understanding of how polarity proteins regulate diverse signaling pathways throughout cancer progression from initiation to metastasis.
authors.affiliation: 1] Rosalind and Morris Goodman Cancer Research Centre, Department of Oncology, McGill University, Montreal, QC, Canada [2] Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Halaoui
authors.affiliation: 1] Rosalind and Morris Goodman Cancer Research Centre, Department of Oncology, McGill University, Montreal, QC, Canada [2] Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
authors.forename: L
authors.initials: L
authors.lastname: McCaffrey
mesh_terms: D000818:Animals; D016764:Cell Polarity / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004847:Epithelial Cells / Q000502:physiology; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D005136:Eye Proteins / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D009419:Nerve Tissue Proteins / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000502:physiology
chemical_list: C448939:CRB1 protein, human; D005136:Eye Proteins; C407989:JTB protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; C480591:SCRIB protein, human; D025521:Tumor Suppressor Proteins