title: Urinary intestinal fatty acid binding protein predicts necrotizing enterocolitis.
abstract: Necrotizing enterocolitis, characterized by sudden onset and rapid progression, remains the most significant gastrointestinal disorder among premature infants. In seeking a predictive biomarker, we found intestinal fatty acid binding protein, an indicator of enterocyte damage, was substantially increased within three and seven days before the diagnosis of necrotizing enterocolitis.
authors.affiliation: W.F. Connell School of Nursing, Boston College, Chestnut Hill, MA; Department of Nursing, Brigham and Women's Hospital, Boston, MA; Department of Newborn Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address: kgregory1@partners.org.
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Gregory
authors.affiliation: Division of Newborn Medicine, Boston Children's Hospital, Boston, MA.
authors.forename: Abigail B
authors.initials: AB
authors.lastname: Winston
authors.affiliation: The Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA.
authors.forename: Hidemi S
authors.initials: HS
authors.lastname: Yamamoto
authors.affiliation: The Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA.
authors.forename: Hassan Y
authors.initials: HY
authors.lastname: Dawood
authors.affiliation: The Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA.
authors.forename: Titilayo
authors.initials: T
authors.lastname: Fashemi
authors.affiliation: The Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.
authors.forename: Raina N
authors.initials: RN
authors.lastname: Fichorova
authors.affiliation: Department of Newborn Medicine, Brigham and Women's Hospital, Boston, MA; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA; The Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA.
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Van Marter
mesh_terms: D015415:Biomarkers / Q000652:urine; D001724:Birth Weight; D015331:Cohort Studies; D018450:Disease Progression; D020345:Enterocolitis, Necrotizing / Q000503:physiopathology* / Q000652:urine*; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D005260:Female; D005865:Gestational Age; D006776:Hospitals, Pediatric; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins