title: Dose estimation of animal experiments at the THOR BNCT beam by NCTPlan and Xplan.
abstract: Dose estimation of animal experiments affects many subsequent derived quantities, such as RBE and CBE values. It is important to ensure the trustiness of calculated dose of the irradiated animals. However, the dose estimation was normally calculated using simplified geometries and tissue compositions, which led to rough results. This paper introduces the use of treatment planning systems NCTplan and Xplan for the dose estimation. A mouse was taken as an example and it was brought to hospital for micro-PET/CT scan. It was found that the critical organ doses of an irradiated mouse calculated by simplified model were unreliable in comparison to Xplan voxel model. The difference could reach the extent of several tenths percent. It is recommended that a treatment planning system should be introduced to future animal experiments to upgrade the data quality.
authors.affiliation: Nuclear Science and Technology Development Center, Hsinchu, Taiwan. Electronic address: yhl.taiwan@gmail.com.
authors.forename: Yuan-Hao
authors.initials: YH
authors.lastname: Liu
authors.affiliation: Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Pei-Yi
authors.initials: PY
authors.lastname: Lee
authors.affiliation: Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Yu-Chuan
authors.initials: YC
authors.lastname: Lin
authors.affiliation: Nuclear Science and Technology Development Center, Hsinchu, Taiwan; Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Fong-In
authors.initials: FI
authors.lastname: Chou
authors.affiliation: Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Wei-Lin
authors.initials: WL
authors.lastname: Chen
authors.affiliation: Nuclear Science and Technology Development Center, Hsinchu, Taiwan.
authors.forename: Yu-Shiang
authors.initials: YS
authors.lastname: Huang
authors.affiliation: Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Shiang-Huei
authors.initials: SH
authors.lastname: Jiang
mesh_terms: D000818:Animals; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation* / Q000662:veterinary*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods* / Q000662:veterinary*; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software
keywords: BNCT; NCTplan; Treatment planning; Xplan