title: CASP-1, -2 and -5 gene polymorphisms and cancer risk: A review and meta-analysis.
abstract: Accumulating evidence suggests the CASP gene family is important in the development of carcinogenesis. These genetic polymorphisms have been extensively investigated as a potential risk factor for cancer, but results have been inconclusive. This Human Genome Epidemiology (HuGE) review and meta-analysis was performed to investigate the associations between CASP-1, -2 and -5 and cancer risk. A literature search of Pubmed, Embase, Web of Science and CBM databases was conducted from inception through September 1st, 2012. Four case-control studies with a total of 1,592 cancer cases and 1,833 healthy controls were included in the present meta-analysis. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Five polymorphisms were examined, including rs501192 (G>A), rs4647297 (C>G), rs507879 (T>C), rs3181320 (G>C) and rs523104 (G>C). Meta-analysis results showed that the rs3181320*C allele/carrier were associated with increased risk of various types of cancers (OR=1.26; 95% CI, 1.04-1.54; P=0.020 and OR=1.33; 95% CI, 1.00-1.75; P=0.047, respectively). However, similar associations were not found in the rs501192, rs4647297, rs507879 and rs523104 polymorphisms (all P>0.05). Results from the current meta-analysis suggest that the rs3181320*C allele/carrier in CASP-5 gene are potential risk factors for cancer.
authors.affiliation: Departments of Nursing, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China.
authors.forename: Ying-Li
authors.initials: YL
authors.lastname: Pan
authors.affiliation: General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Departments of Nursing, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China.
authors.forename: Cai-Xiang
authors.initials: CX
authors.lastname: Gao
authors.affiliation: Departments of Nursing, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China.
authors.forename: Zuo
authors.initials: Z
authors.lastname: Shang
authors.affiliation: Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Ning
authors.affiliation: General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China.
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
keywords: apoptosis; cancer; caspases; meta-analysis; polymorphism