title: TAP1 I333V gene polymorphism and type 1 diabetes mellitus: a meta-analysis of 2248 cases.
abstract: Transporter associated with antigen processing 1 (TAP1) I333V gene polymorphism has been suggested to be associated with type 1 diabetes mellitus (T1DM) susceptibility. However, the results from individual studies are inconsistent. To explore the association of TAP1 I333V gene polymorphisms with T1DM, a meta-analysis involving 2246 cases from 13 individual studies was conducted. The pooled odd ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were evaluated by a fixed-effect model. A significant relationship was observed between TAP1 I333V gene polymorphism and T1DM in allelic (OR: 1.35, 95% CI: 1.08-1.68, P = 0.007), dominant (OR: 1.462, 95% CI: 1.094-1.955, P = 0.010), homozygous (OR: 1.725, 95% CI: 1.082-2.752, P = 0.022), heterozygous (OR: 1.430, 95% CI: 1.048-1.951, P = 0.024) and additive (OR: 1.348, 95% CI: 1.084-1.676, P = 0.007) genetic models. No significant association between TAP1 I333V gene polymorphism and T1DM was detected in a recessive genetic model (OR: 1.384, 95% CI: 0.743-2.579, P = 0.306) in the entire population, especially among Caucasians. No significant association between them was found in an Asian or African population. TAP1 I333V gene polymorphism was significantly associated with increased T1DM risk. V allele carriers might be predisposed to T1DM susceptibility.
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Si-Si
authors.initials: SS
authors.lastname: Pang
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Min
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Yang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Xin-Zheng
authors.initials: XZ
authors.lastname: Lu
authors.forename: Lian-Sheng
authors.initials: LS
authors.lastname: Wang
authors.forename: Xiang-Ming
authors.initials: XM
authors.lastname: Wang
authors.forename: Yun
authors.initials: Y
authors.lastname: Qian
authors.forename: Chuan-Wei
authors.initials: CW
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Ai-Ling
authors.initials: AL
authors.lastname: Chen
mesh_terms: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000483:Alleles; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D005799:Genes, Dominant; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006720:Homozygote; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias
chemical_list: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; C073119:TAP1 protein, human
keywords: I333V; Transporter associated with antigen processing 1; polymorphism; type 1 diabetes mellitus