title: Association between use of FK506 and prevalence of post-transplantation diabetes mellitus in kidney transplant patients.
abstract: BACKGROUND
  Tacrolimus (FK506) use has been suggested as a risk factor for post-transplantation diabetes mellitus (PTDM) because it can impair insulin secretion. This association warrants further investigation. This study aimed to examine the prevalence of PTDM and its association with FK506 use in kidney transplant recipients. The study also aimed to examine the relationship of FK506 use and diabetes-related biologic markers.
  
  
  METHODS
  A retrospective chart review was used to collect data at a medical center in northern Taiwan from September 2003 to February 2012. PTDM was defined with the use of the criteria of the American Diabetes Association.
  
  
  RESULTS
  Among 166 patients included in the analysis, PTDM was reported in 49 patients (29.5%). A total of 93 patients used the FK506 regimen, of whom 34 (36.6%) were PTDM cases. Logistic regression showed that FK506 use (odds ratio [OR], 2.71; 95% confidence interval [CI], 1.20-6.11; P = .016) and older age (OR,1.08; 95% CI, 1.03-1.13; P = .001) were significant risk factors for PTDM. In addition, FK506 use in PTDM cases was associated with a significantly higher hemoglobin A1c level (7.55 vs 5.81; P = .01) and a borderline significantly higher insulin resistance index (3.24 vs 1.92; P = .053) than was FK506 use without the presence of PTDM.
  
  
  CONCLUSIONS
  Older age and an FK506 regimen were important predictors of the prevalence of PTDM. Greater early detection and prevention efforts for PTDM are needed for older transplant recipients. PTDM patients with an FK506 regimen had higher hemoglobin A1c levels and insulin resistance index than did patients who did not use FK506. The association of serum indicators with FK506 use in the prevalence of PTDM warrants further investigation.
authors.affiliation: School of Nursing, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: L C
authors.initials: LC
authors.lastname: Weng
authors.affiliation: Transplantation Center and Urology Surgery, Chang Gung Medical Foundation-Linkuo Medical Center, Taoyuan, Taiwan. Electronic address: zorro@cgmh.org.tw.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Chiang
authors.affiliation: Department of Nursing, Chang Gung Medical Foundation-Linkuo Medical Center, Taoyuan, Taiwan.
authors.forename: M H
authors.initials: MH
authors.lastname: Lin
authors.affiliation: Department of Nursing, Chang Gung Medical Foundation-Linkuo Medical Center, Taoyuan, Taiwan.
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsieh
authors.affiliation: Department of Nursing, Chang Gung Medical Foundation-Linkuo Medical Center, Taoyuan, Taiwan.
authors.forename: S C
authors.initials: SC
authors.lastname: Lin
authors.affiliation: Department of Nursing, Chang Gung Medical Foundation-Linkuo Medical Center, Taoyuan, Taiwan.
authors.forename: T Y
authors.initials: TY
authors.lastname: Wei
authors.affiliation: School of Nursing, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: H F
authors.initials: HF
authors.lastname: Chou
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016559:Tacrolimus / Q000627:therapeutic use*
chemical_list: D006442:Glycated Hemoglobin; D007166:Immunosuppressive Agents; D016559:Tacrolimus; C517652:hemoglobin A1c protein, human