title: Cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia.
abstract: BACKGROUND
  Chronic pain disorders are presumed to induce changes in brain grey and white matters. Few studies have focused CNS alterations in trigeminal neuralgia (TN).
  
  
  METHODS
  The aim of this study was to explore changes in white matter microstructure in TN subjects using diffusion tensor images (DTI) with tract-based spatial statistics (TBSS); and cortical thickness changes with surface based morphometry. Twenty-four patients with classical TN (37-67 y-o) and 24 healthy controls, matched for age and sex, were included in the study.
  
  
  RESULTS
  Comparing patients with controls, no diffusivity abnormalities of brain white matter were detected. However, a significant reduction in cortical thickness was observed at the left cuneus and left fusiform cortex in the patients group. The thickness of the fusiform cortex correlated negatively with the carbamazepine dose (p = 0.023).
  
  
  CONCLUSIONS
  Since the cuneus and the fusiform gyrus have been related to the multisensory integration area and cognitive processing, as well as the retrieval of shock perception conveyed by Aδ fibers, our results support the role of these areas in TN pathogenesis. Whether such changes occurs as an epiphenomenon secondary to daily stimulation or represent a structural predisposition to TN in the light of peripheral vascular compression is a matter of future studies.
authors.affiliation: Department of Radiology, Clementino Fraga Filho University Hospital, Universidade Federal do Rio de Janeiro, Rua Rodolpho Paulo Rocco, 255, Cidade Universitária, Rio de Janeiro, CEP:21941-913, Brazil. parise@infolink.com.br.
authors.forename: Maud
authors.initials: M
authors.lastname: Parise
authors.forename: Tadeu Takao Almodovar
authors.initials: TT
authors.lastname: Kubo
authors.forename: Thomas Martin
authors.initials: TM
authors.lastname: Doring
authors.forename: Gustavo
authors.initials: G
authors.lastname: Tukamoto
authors.forename: Maurice
authors.initials: M
authors.lastname: Vincent
authors.forename: Emerson Leandro
authors.initials: EL
authors.lastname: Gasparetto
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000473:pathology; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology*; D058748:Pain Perception / Q000502:physiology; D013702:Temporal Lobe / Q000473:pathology*; D014277:Trigeminal Neuralgia / Q000473:pathology* / Q000503:physiopathology