title: Novel and nonpharmacologic approaches to cardio-protection in hypertension.
abstract: Hypertension has wide (30-45 %) prevalence in the general population and is related to important increases in overall cardiovascular morbidity and mortality. Despite lifestyle modifications and optimal medical therapy (three drugs, one being diuretic), about 5-20 % of hypertensives are affected by resistant hypertension. Chronic high blood pressure has adverse effects on the heart and other organs such as the kidneys and vasculature. Renal sympathetic denervation and baroreceptor stimulation are invasive approaches initially investigated to treat resistant hypertension. Their pleiotropic effects appear promising in cardiovascular remodeling, heart failure and arrhythmias and could potentially affect cardiovascular morbidity and mortality.
authors.affiliation: Klinik für Innere Medizin III (Kardiologie, Angiologie und Internistische Intensivmedizin), Universitätsklinikum des Saarlandes, Kirrberger Str. 1, Geb. 40, 66421, Homburg, Saar, Germany.
authors.forename: Luca
authors.initials: L
authors.lastname: Donazzan
authors.forename: Felix
authors.initials: F
authors.lastname: Mahfoud
authors.forename: Dominik
authors.initials: D
authors.lastname: Linz
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ewen
authors.forename: Christian
authors.initials: C
authors.lastname: Ukena
authors.forename: Michael
authors.initials: M
authors.lastname: Böhm
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002319:Cardiovascular System / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology*; D011311:Pressoreceptors / Q000378:metabolism / Q000503:physiopathology; D013562:Sympathectomy / Q000379:methods
chemical_list: D000959:Antihypertensive Agents