title: Serum omentin-1 as a disease activity marker for Crohn's disease.
abstract: OBJECTIVE
  It remains challenging to determine the inflammatory activity in Crohn's disease (CD) for lack of specific laboratory markers. Recent studies suggest that serum omentin-1 is associated with inflammatory response. We aimed to assess the potential of serum omentin-1 as a marker of disease activity in CD patients.
  
  
  METHODS
  Serum omentin-1 concentrations were determined by enzyme-linked immunosorbent assay (ELISA) in patients with CD (n = 240), functional gastrointestinal disorders (FGDs, n = 120), and healthy controls (HC, n = 60) and evaluated for correlation with disease activity. Expression of omentin-1 in colonic tissues from patients with CD was also analyzed by real-time PCR and Western blotting. Serum omentin-1 levels as an activity index were evaluated using a receiver operating characteristic (ROC) curve.
  
  
  RESULTS
  Serum omentin-1 concentrations were significantly decreased in active CD patients compared with patients in remission, FGDs, and HC (all P < 0.001). Expression of omentin-1 was decreased at mRNA and protein levels in inflamed colonic tissues in active CD than that in noninflamed colonic tissues. Serum omentin-1 levels were negatively correlated with disease activity in CD, better than C-reactive protein (CRP).
  
  
  CONCLUSIONS
  Our results indicate that serum and colonic omentin-1 expressions are decreased in active CD patients. The correlation of serum omentin-1 with disease activity in CD is superior to that of CRP. Serum omentin-1 is a potential marker for CD disease activity.
authors.affiliation: Department of Gastroenterology, Liaocheng People's Hospital, Liaocheng 252000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Pathology, Liaocheng Second People's Hospital, Linqing 252600, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Gastroenterology, Liaocheng People's Hospital, Liaocheng 252000, China.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Radiology, Binzhou Medical College Hospital, Binzhou 256603, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Pharmacy, Liaocheng International Peace Hospital, Liaocheng 252000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lu
authors.affiliation: Central Laboratory, Liaocheng People's Hospital, Liaocheng 252000, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ren
authors.affiliation: Department of Pathology, Liaocheng People's Hospital, Liaocheng 252000, China.
authors.forename: Xinqian
authors.initials: X
authors.lastname: Dong
authors.affiliation: Department of Gastroenterology, Liaocheng People's Hospital, Liaocheng 252000, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Sang
mesh_terms: D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003106:Colon / Q000378:metabolism / Q000473:pathology; D003424:Crohn Disease / Q000097:blood* / Q000473:pathology; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins