title: Dose-response effect of a novel functional fibre, PolyGlycopleX(®), PGX(®), on satiety.
abstract: The objective of this research was to determine the dose-response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX(®) (PGX(®)), [(α-D-glucurono-α-manno-β-D-manno-β-D-gluco), (α-Lgulurono-β-D mannurono), (β-D-gluco-β-D-mannan)] on satiety, and to gain insight into the underlying mechanisms that lead to appetite inhibition. Healthy subjects (n = 10), aged between 20.3 and 29.2 years, consumed PGX(®), in granular form at 2.5, 5.0 and 7.5 g, and a 5g inulin control, with a standard breakfast. The PGX(®) doses of 2.5 and 7.5 g mixed with water at the start of breakfast increased satiety (iAUC of 140.0 and 157.7, P = 0.025 and 0.001, respectively) compared to the control. The most effective dose (7.5g) was palatable and corresponded to a 34% increase in fullness, measured using a visual analogue scale and incremental area under the curve, and resulted in a delayed postprandial glycaemic response when compared with the control.
authors.affiliation: School of Public Health, Faculty of Health Sciences, Curtin University of Technology, GPO Box U1987, Perth, WA 6845, Australia. Electronic address: v.solah@curtin.edu.au.
authors.forename: Vicky A
authors.initials: VA
authors.lastname: Solah
authors.affiliation: Boden Institute of Obesity, Nutrition and Exercise and the School of Molecular Bioscience, University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Jennie C
authors.initials: JC
authors.lastname: Brand-Miller
authors.affiliation: Boden Institute of Obesity, Nutrition and Exercise and the School of Molecular Bioscience, University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Fiona S
authors.initials: FS
authors.lastname: Atkinson
authors.affiliation: Factors Group R and D, Burnaby, BC, V3N 4S9, Canada.
authors.forename: Roland J
authors.initials: RJ
authors.lastname: Gahler
authors.affiliation: Canadian Centre for Functional Medicine, Coquitlam, BC, V3K 6Y2, Canada.
authors.forename: Veronica
authors.initials: V
authors.lastname: Kacinik
authors.affiliation: Canadian Centre for Functional Medicine, Coquitlam, BC, V3K 6Y2, Canada; Food, Nutrition and Health Program, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Lyon
authors.affiliation: School of Public Health, Faculty of Health Sciences, Curtin University of Technology, GPO Box U1987, Perth, WA 6845, Australia; Food, Nutrition and Health Program, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada; InovoBiologic Inc., Calgary, AB, Y2N 4Y7, Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Wood
mesh_terms: D000328:Adult; D000464:Alginates / Q000008:administration & dosage* / Q000494:pharmacology; D001066:Appetite; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism*; D004043:Dietary Fiber / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006801:Humans; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage* / Q000494:pharmacology; D019518:Postprandial Period; D012527:Satiation / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000464:Alginates; D001786:Blood Glucose; D004043:Dietary Fiber; D004338:Drug Combinations; C540519:PolyGlycoplex; D011135:Polysaccharides, Bacterial
keywords: Dose; Fibre; Satiety