title: Thrombolysis and reperfusion: advanced understanding of early management strategies in acute ischemic stroke.
abstract: Currently, intravenous (IV) thrombolysis within 3 hours from stroke onset is the only approved treatment in acute ischemic stroke (AIS). Although effective, the definition of therapeutic time window and appropriate patient selection still remains controversial. Notably, early endovascular treatment strategies may serve as an adjunct therapy for time window extension in AIS. In this article, we review the safety and efficacy of IV thrombolysis in AIS as it pertains to the optimal time window, the selection of eligible patients, and in combination with endovascular treatment. Combined clinical application of IV thrombolysis and endovascular therapy may improve the therapeutic outcomes for AIS patients.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.forename: Xinying
authors.initials: X
authors.lastname: Zou
authors.forename: Christopher
authors.initials: C
authors.lastname: Sy
authors.forename: Haiqiang
authors.initials: H
authors.lastname: Qin
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Liao
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
mesh_terms: D002545:Brain Ischemia / Q000628:therapy*; D057510:Endovascular Procedures / Q000009:adverse effects / Q000379:methods; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D015424:Reperfusion / Q000009:adverse effects / Q000379:methods; D020521:Stroke / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000379:methods; D013997:Time Factors
keywords: Acute ischemic stroke,; Endovascular therapy; Thrombolysis,