title: Liver transplant complications in hepatitis C infected recipients: recurrence versus rejection.
abstract: Despite improvement on outcomes post liver transplantation (LT), complications such as HCV recurrence (HCV-rec) and acute cellular rejection (ACR) continue to be a challenge for transplant physicians. Accurate diagnostic tools to better dissect between those complications post-LT are crucial for prompt and correct diagnosis and treatment. It is well known that the overlapping features of clinical and histo-pathological characteristics between these conditions turn difficult the appropriate differential diagnosis. Recently, new technological advances had supported the field of biomarker discovery in many diseases. Disease biomarkers capable to differentiate ACR versus HCV-rec post-LT is a long waited task in the transplant community. This editorial describes and discusses potential biomarkers of disease differentiation including recent reports in the field of genomics, proteomics, immunohistochemistry among other technologies.
authors.affiliation: Department of Surgery, University of Virginia, P.O. Box 800625, 904 Lane Rd, Charlottesville, VA 22908-0625, USA.
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Gehrau
authors.forename: Valeria R
authors.initials: VR
authors.lastname: Mas
authors.forename: Jihee L
authors.initials: JL
authors.lastname: Suh
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Maluf
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000032:analysis; D003937:Diagnosis, Differential; D005819:Genetic Markers; D006084:Graft Rejection / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D006526:Hepatitis C / Q000175:diagnosis / Q000235:genetics / Q000601:surgery* / Q000821:virology; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D025202:Molecular Diagnostic Techniques / Q000379:methods; D011237:Predictive Value of Tests; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D005819:Genetic Markers
keywords: HCV recurrence; acute rejection; biomarkers; gene expression; liver transplantation; miRNA; microarray