title: Determination of optimal acquisition time of [(18)F]FCWAY PET for imaging serotonin 1A receptors in the healthy male subjects.
abstract: The purpose of this research is to find optimal acquisition time point of [(18)F]FCWAY PET for the assessment of serotonin 1A receptor (5-HT1A) density. To achieve this goal, we examined the specific-to-nonspecific ratios in various brain regions. The cerebellum has very few 5-HT1A receptors in the brain, so we set this region as the reference tissue. As a result, specific-to-nonspecific binding ratios in the frontal, temporal cortex and the hippocampus were steadily increased at 90 min after injection and remained stable at 120 min. In addition, the binding ratio of the late time was significantly higher than that of the previous time points. From these results, we recommend that 90 min p.i. is a better single time point for the analysis rather than previous time points for assessing [(18)F]FCWAY binding to 5-HT1A receptors.
authors.affiliation: Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul 135-720, Republic of Korea.
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul 135-720, Republic of Korea.
authors.forename: Minkyung
authors.initials: M
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul 135-720, Republic of Korea.
authors.forename: Tae Joo
authors.initials: TJ
authors.lastname: Jeon
authors.affiliation: Department of Psychiatry and Institute of Human Behavioral Sciences, Seoul National University College of Medicine, Seoul, 120-752, Republic of Korea.
authors.forename: Soo-Hee
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Hwaam High School, Ulsan, 682-020, Republic of Korea.
authors.forename: Ye Ji
authors.initials: YJ
authors.lastname: Choi
authors.affiliation: Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul 135-720, Republic of Korea.
authors.forename: Yu Kyung
authors.initials: YK
authors.lastname: Lee
authors.affiliation: Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul,135-720, Republic of Korea.
authors.forename: Jae-Jin
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul 135-720, Republic of Korea. Electronic address: ryuyh@yuhs.ac.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Ryu
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D003510:Cyclohexanes / Q000493:pharmacokinetics; D005462:Fluorine Radioisotopes; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D010879:Piperazines / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D044282:Receptor, Serotonin, 5-HT1A / Q000032:analysis* / Q000378:metabolism
chemical_list: D003510:Cyclohexanes; D005462:Fluorine Radioisotopes; C493883:N-(2-(4-(2-methoxyphenyl)piperazino))-N-(2-pyridinyl) trans-4-fluorocyclohexanecarboxamide; D010879:Piperazines; D019275:Radiopharmaceuticals; D044282:Receptor, Serotonin, 5-HT1A
keywords: 5-HT(1A) receptors; Optimal acquisition time; PET; [(18)F]FCWAY