title: Asymmetric synthesis of P-stereogenic diarylphosphinites by palladium-catalyzed enantioselective addition of diarylphosphines to benzoquinones.
abstract: The reaction of phenyl(2,4,6-trimethylphenyl)phosphine with a substituted benzoquinone in the presence of a chiral phosphapalladacycle complex as a catalyst and triethylamine in chloroform at -45 °C proceeded in a new type of addition manner to give a high yield of a 4-hydroxyphenyl phenyl(2,4,6-trimethylphenyl)phosphinite with 98% enantioselectivity, which is a versatile intermediate readily convertible into various phosphines and their derivatives with high enantiomeric purity.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore 637371, Singapore.
authors.forename: Yinhua
authors.initials: Y
authors.lastname: Huang
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Li
authors.forename: Pak-Hing
authors.initials: PH
authors.lastname: Leung
authors.forename: Tamio
authors.initials: T
authors.lastname: Hayashi