title: Efficacy of 1.0% chlorhexidine-gluconate ethanol compared with 10% povidone-iodine for long-term central venous catheter care in hematology departments: a prospective study.
abstract: The efficacy of 1% chlorhexidine-gluconate ethanol and 10% povidone-iodine for skin antisepsis of central venous catheter (CVC) sites were compared among hematology patients. The CVC site colonization rates of those groups were 11.9% and 29.2%, respectively, and the catheter-associated blood stream infections were 0.75 and 3.62 per 1,000 catheter-days, respectively. One percent chlorhexidine-gluconate ethanol was superior to povidone-iodine to reduce skin colonizers at CVC sites even when catheters were used for long duration.
authors.affiliation: Department of Infection Control, Fukushima Medical University, Fukushima City, Fukushima Prefecture, Japan. Electronic address: n-yama@fmu.ac.jp.
authors.forename: Natsuo
authors.initials: N
authors.lastname: Yamamoto
authors.affiliation: Hematology Division, Northern Fukushima Medical Center, Date City, Fukushima Prefecture, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Kimura
authors.affiliation: Graduate School of Nursing, Miyagi University, Kurokawagun, Miyagi Prefecture, Japan.
authors.forename: Hanako
authors.initials: H
authors.lastname: Misao
authors.affiliation: Department of Cardiology and Hematology, Fukushima Medical University, Fukushima City, Fukushima Prefecture, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Matsumoto
authors.affiliation: Department of Infection Control, Fukushima Medical University, Fukushima City, Fukushima Prefecture, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Imafuku
authors.affiliation: Hematology Division, Northern Fukushima Medical Center, Date City, Fukushima Prefecture, Japan.
authors.forename: Akemi
authors.initials: A
authors.lastname: Watanabe
authors.affiliation: Department of Infection Control, Fukushima Medical University, Fukushima City, Fukushima Prefecture, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Mori
authors.affiliation: Department of Infection Control, Fukushima Medical University, Fukushima City, Fukushima Prefecture, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Department of Infection Control, Fukushima Medical University, Fukushima City, Fukushima Prefecture, Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Miura
authors.affiliation: Department of Infection Control, Fukushima Medical University, Fukushima City, Fukushima Prefecture, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Abe
authors.affiliation: Department of Infection Control, Fukushima Medical University, Fukushima City, Fukushima Prefecture, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Toba
authors.affiliation: Department of Cardiology and Hematology, Fukushima Medical University, Fukushima City, Fukushima Prefecture, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Department of Cardiology and Hematology, Fukushima Medical University, Fukushima City, Fukushima Prefecture, Japan.
authors.forename: Kazuei
authors.initials: K
authors.lastname: Ogawa
authors.affiliation: Department of Infection Control, Fukushima Medical University, Fukushima City, Fukushima Prefecture, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Kanemitsu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D062905:Central Venous Catheters / Q000382:microbiology*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology*; D004203:Disinfection / Q000379:methods*; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D006405:Hematology; D006748:Hospital Departments; D006801:Humans; D008297:Male; D008875:Middle Aged; D011206:Povidone-Iodine / Q000494:pharmacology*; D011446:Prospective Studies; D018805:Sepsis / Q000453:epidemiology / Q000517:prevention & control*; D012874:Skin Diseases, Infectious / Q000453:epidemiology / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D004202:Disinfectants; D000431:Ethanol; D011206:Povidone-Iodine; C010882:chlorhexidine gluconate; D002710:Chlorhexidine
keywords: Antiseptics; Catheter-associated blood stream infection; Hematology patient