title: Frequencies of HLA-DQ2 and HLA-DQ8 haplotypes in Czech and Slovak coeliac patients and the healthy population.
abstract: Coeliac disease is an autoimmune disorder with genetic predisposition. The aim was to determine the frequency of HLA-DQ2 and HLA-DQ8 in Czech and Slovak patients and the healthy population. The study included 127 patients and 66 healthy volunteers. HLA-DQ2 was identified in 85.03% patients, and 24.24% healthy individuals (P=0.0001; OR17.7632; CI=8.4347-37.4088). HLA-DQ8 was identified in 11.81% patients and 15.5% healthy individuals. HLA-DQ8 occurred more often in HLA-DQ2-negative patients compared to HLA-DQ2-positive patients (P=0.0494; OR3.5; CI 1.0428-11.7468). At least one of the studied HLA-variants was found more often in patients than in healthy individuals (P=0.0001; OR58.8; CI 7.6856-449.8602).
authors.affiliation: Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic.
authors.forename: Katerina
authors.initials: K
authors.lastname: Wroblova
authors.affiliation: Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Kolorz
authors.affiliation: Gastroenterological Clinic SMU and University Hospital in Bratislava-Petrzalka, Bratislava, Slovak Republic.
authors.forename: Igor
authors.initials: I
authors.lastname: Pav
authors.affiliation: Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Horakova
authors.affiliation: Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic.
authors.forename: Petra
authors.initials: P
authors.lastname: Filipova
authors.affiliation: Department of Natural Drugs, UVPS Brno, Brno, Czech Republic.
authors.forename: Milan
authors.initials: M
authors.lastname: Bartos
authors.affiliation: Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic.
authors.forename: Ladislava
authors.initials: L
authors.lastname: Bartosova
mesh_terms: D002446:Celiac Disease / Q000235:genetics* / Q000473:pathology; D018153:Czech Republic; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D018154:Slovakia
chemical_list: D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; C109756:HLA-DQ8 antigen