title: FoxD3 deficiency promotes breast cancer progression by induction of epithelial-mesenchymal transition.
abstract: The transcription factor forkhead box D3 (FOXD3) plays an important role in the development of neural crest and gastric cancer cells. However, the function and mechanisms of FOXD3 in the breast tumorigenesis and progression is still limited. Here, we report that FOXD3 is a tumor suppressor of breast cancer tumorigenicity and aggressiveness. We found that FOXD3 is down-regulated in breast cancer tissues. Patients with low FOXD3 expression have a poor outcome. Depletion of FOXD3 expression promotes breast cancer cell proliferation and invasion in vitro, whereas overexpression of FOXD3 inhibits breast cancer cell proliferation and invasion both in vitro and in vivo. In addition, depletion of FOXD3 is linked to epithelial-mesenchymal transition (EMT)-like phenotype. Our results indicate FOXD3 exhibits tumor suppressive activity and may be useful for breast therapy.
authors.affiliation: Department of General Surgery, The People's Hospital of Wuqing, Tianjin, China.
authors.forename: Tian-Li
authors.initials: TL
authors.lastname: Chu
authors.affiliation: Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
authors.forename: Hong-Meng
authors.initials: HM
authors.lastname: Zhao
authors.affiliation: Department of Respiration, Affiliated Hospital of Medical College of Chinese People's Armed Police Force, Tianjin, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
authors.forename: Ao-Xiang
authors.initials: AX
authors.lastname: Chen
authors.affiliation: Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Sun
authors.affiliation: Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. Electronic address: gejie198003@163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Ge
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D051858:Forkhead Transcription Factors / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009361:Neoplasm Invasiveness
chemical_list: C503514:FOXD3 protein, human; D051858:Forkhead Transcription Factors
keywords: Breast cancer; Epithelial–mesenchymal transition; FoxD3