title: Ultrasound promoted one pot synthesis of novel fluorescent triazolyl spirocyclic oxindoles using DBU based task specific ionic liquids and their antimicrobial activity.
abstract: Spirocyclic oxindoles and triazolyl derivatives posses remarkable biological activities. In present work, we have described an efficient one pot four-component domino reaction of 1-(prop-2-ynyl)indoline-2,3-dione, cyclic 1,3-diketones, malononitrile and various aryl azides in DBU based ionic liquids [DBU-H]OAc and [DBU-Bu]OH under ultrasonic irradiation for the construction of heterocycles, comprising spiro-oxindole, 2-amino-4H-pyran, and 1,2,3-triazoles substructures. The antimicrobial activity of all compounds has been investigated against six microbial strains. All compounds showed good antimicrobial activity. All newly synthesized compounds exhibit fluorescence in methanol with large stoke shift.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110007, India.
authors.forename: Harjinder
authors.initials: H
authors.lastname: Singh
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110007, India.
authors.forename: Jayant
authors.initials: J
authors.lastname: Sindhu
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110007, India. Electronic address: jmkhurana@chemistry.du.ac.in.
authors.forename: Jitender M
authors.initials: JM
authors.lastname: Khurana
authors.affiliation: Department of Microbiology, Kurukshetra University, Kurukshetra, Haryana, India.
authors.forename: Chetan
authors.initials: C
authors.lastname: Sharma
authors.affiliation: Department of Microbiology, Kurukshetra University, Kurukshetra, Haryana, India.
authors.forename: K R
authors.initials: KR
authors.lastname: Aneja
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D005456:Fluorescent Dyes / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D052578:Ionic Liquids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D000078183:Oxindoles; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013141:Spiro Compounds / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology; D014465:Ultrasonics
chemical_list: D000900:Anti-Bacterial Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D005456:Fluorescent Dyes; D007211:Indoles; D052578:Ionic Liquids; D000078183:Oxindoles; D013141:Spiro Compounds; D014230:Triazoles; C022960:2-oxindole; C031033:1,8-diazabicyclo(5.4.0)undec-7-ene
keywords: 1,2,3-Triazole; Antimicrobial activity; Ionic liquids; Multicomponent reactions; Ultrasonic irradiation