title: Study on anti-atherosclerotic effect of Suxiao Jiuxin Pill and its mechanism.
abstract: BACKGROUND
  Suxiao Jiuxin Pill is composed of Ligusticum wallichii, Borneolum Syntheticum and other drugs; it has qi promoting and blood circulation activating, meridian dredging and pain relieving efficacies. The objective of this paper is to study the effect of Suxiao Jiuxin Pill (quick-acting heart reliever), in atherosclerosis (AS) rat model and explore the mechanism for its prevention and treatment of AS.
  
  
  METHODS
  AS rat model was established by high cholesterol diet and single intra-peritoneal injection of increased dose of vitamin D3.
  
  
  RESULTS
  Compared with the model group, Suxiao Jiuxin Pill medium-and high-dose groups and atorvastatin group can effectively regulate lipid metabolism.
  
  
  CONCLUSIONS
  We conclude that Suxiao Jiuxin Pill has a good hypo-lipidemic effect, and can inhibit the occurrence and development of AS.
authors.affiliation: The Military General Hospital of BeiJing PLASurgical Dept Vascular Diseases, Beijing, China.
authors.forename: Qing-Xu
authors.initials: QX
authors.lastname: Guo
authors.affiliation: The Military General Hospital of BeiJing PLASurgical Dept Vascular Diseases, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The Military General Hospital of BeiJing PLASurgical Dept Vascular Diseases, Beijing, China.
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Li
authors.affiliation: The Military General Hospital of BeiJing PLASurgical Dept Vascular Diseases, Beijing, China.
authors.forename: Gui-Fu
authors.initials: GF
authors.lastname: Zhang
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D002762:Cholecalciferol / Q000008:administration & dosage / Q000009:adverse effects; D002791:Cholesterol, Dietary / Q000009:adverse effects / Q000378:metabolism*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D030004:Ligusticum; D008297:Male; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002791:Cholesterol, Dietary; D004365:Drugs, Chinese Herbal; D000960:Hypolipidemic Agents; C543119:suxiao jiuxinwan; D002762:Cholecalciferol
keywords: Suxiao Jiuxin Pill; atherosclerosis; atorvastatin