title: Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5-fluorouracil-based chemotherapy.
abstract: Biliary tract cancer (BTC) is a relatively uncommon type of cancer, accounting for ∼4% of the malignant neoplasms of the gastrointestinal tract. The aim of this study was to determine whether the expression of thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) predict clinical outcome in BTC patients treated with adjuvant 5-fluorouracil (5-FU)-based chemotherapy. TS and TP expression were found to be significantly correlated with cancer location (P=0.044 and 0.031, respectively). The multivariate analysis revealed that age [hazard ratio (HR)=2.157, P=0.008], stage (HR=2.234, P<0.001), resection margin status (HR=2.748, P=0.004) and TP expression (HR=2.014, P=0.039) were independently associated with overall survival (OS).
authors.affiliation: Department of Surgery, Haeundae Paik Hospital, College of Medicine, Inje University;
authors.forename: Kwan Woo
authors.initials: KW
authors.lastname: Kim
authors.affiliation: Departments of Internal Medicine, College of Medicine, Dong-A University, Busan, Republic of Korea.
authors.forename: Hyuk-Chan
authors.initials: HC
authors.lastname: Kwon
authors.affiliation: Departments of Internal Medicine, College of Medicine, Dong-A University, Busan, Republic of Korea.
authors.forename: Sung-Hyun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Departments of Internal Medicine, College of Medicine, Dong-A University, Busan, Republic of Korea.
authors.forename: Sung Yong
authors.initials: SY
authors.lastname: Oh
authors.affiliation: Departments of Internal Medicine, College of Medicine, Dong-A University, Busan, Republic of Korea.
authors.forename: Suee
authors.initials: S
authors.lastname: Lee
authors.affiliation: Departments of Internal Medicine, College of Medicine, Dong-A University, Busan, Republic of Korea.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Departments of Internal Medicine, College of Medicine, Dong-A University, Busan, Republic of Korea.
authors.forename: Myung Hwan
authors.initials: MH
authors.lastname: Roh
authors.affiliation: Surgery, College of Medicine, Dong-A University, Busan, Republic of Korea.
authors.forename: Min Chan
authors.initials: MC
authors.lastname: Kim
authors.affiliation: Surgery, College of Medicine, Dong-A University, Busan, Republic of Korea.
authors.forename: Ki Han
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Surgery, College of Medicine, Dong-A University, Busan, Republic of Korea.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Surgery, College of Medicine, Dong-A University, Busan, Republic of Korea.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Roh
authors.affiliation: Pathology, College of Medicine, Dong-A University, Busan, Republic of Korea.
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Jeong
authors.affiliation: Department of Surgery, Haeundae Paik Hospital, College of Medicine, Inje University;
authors.forename: Hyo-Jin
authors.initials: HJ
authors.lastname: Kim
keywords: 5-fluorouracil; biliary tract cancer; thymidine phosphorylase