title: Ruthenium(II)-catalyzed C(sp3)-H α-alkylation of pyrrolidines.
abstract: A catalytic system comprising [RuCl2(PPh3)3], AgOTf, and BINAP enabled atom- and step-economical additions of C(sp(3))-H bonds onto unactivated alkenes 2 under comparably mild reaction conditions. The pyridyl directing group was easily removed to furnish the corresponding (NH)-free amines with ample scope.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität , Tammannstrasse 2, 37077 Göttingen, Germany.
authors.forename: Marvin
authors.initials: M
authors.lastname: Schinkel
authors.forename: Lianhui
authors.initials: L
authors.lastname: Wang
authors.forename: Kris
authors.initials: K
authors.lastname: Bielefeld
authors.forename: Lutz
authors.initials: L
authors.lastname: Ackermann