title: Restoration of jaw bone tissue defect using osteoplastic material.
abstract: The aim of the study was to repair mandibular bone defect using BIO-OSS artificial bone implantation. The experiment was conducted on 30 white laboratory rats. Defect in the bone of lower jaw was created surgically. Animals were divided into 2 groups. 15 animals were allocated in control group. Another 15 animals were allocated in the BIO-OSS treatment group.
  
  
  METHODS
  analysis revealed bone defect in 6-month after modeling of bone defect. There was no pronounced proliferation of connective tissue visible in the defect area. Treatment group: In the samples of treated group, BIO-OSS bone mass formed basophilic fiber-like structures. It was surrounded with the thin proliferative connective and granulation tissues.
  
  
  CONCLUSIONS
  proposed technique of bone defect reconstruction is an effective and sustainable method and can be recommended for wider use in clinical practice.
authors.affiliation: Medical Research Institute, Ilia State University, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Grdzelidze
authors.affiliation: Medical Research Institute, Ilia State University, Tbilisi, Georgia.
authors.forename: A
authors.initials: A
authors.lastname: Machavariani
authors.affiliation: Medical Research Institute, Ilia State University, Tbilisi, Georgia.
authors.forename: G
authors.initials: G
authors.lastname: Menabde
authors.affiliation: Medical Research Institute, Ilia State University, Tbilisi, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Gvelesiani
authors.affiliation: Medical Research Institute, Ilia State University, Tbilisi, Georgia.
authors.forename: I
authors.initials: I
authors.lastname: Amiranashvili
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D015519:Bone Density; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use; D001842:Bone and Bones / Q000473:pathology / Q000601:surgery; D008334:Mandible / Q000473:pathology / Q000601:surgery*; D008903:Minerals / Q000627:therapeutic use*; D051381:Rats; D014945:Wound Healing / Q000187:drug effects
chemical_list: C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D008903:Minerals