title: [Frameless stereotactic biopsy: diagnostic yield and complications].
abstract: OBJECTIVE
  The aim of this study was to evaluate the variables that could modify the diagnostic yield of frameless stereotactic biopsy, as well as its complications.
  
  
  METHODS
  This was a retrospective study of frameless stereotactic biopsies carried out between July 2008 and December 2011 at Donostia University Hospital. The variables studied were size, distance to the cortex, contrast uptake and location.
  
  
  RESULTS
  A total of 70 patients were included (75 biopsies); 39 males and 31 females with an age range between 39 and 83 years. The total diagnostic yield in our series was 97.1%. For lesions >19mm, the technique offered a sensitivity of 95.2% (95% CI: 86.9-98.4) and specificity of 57.1% (95% CI: 25.0-84.2). The yield was lower for lesions within 17mm of the cortex: sensitivity of 74.6% (95% CI: 62.1-84.7) and specificity of 71.4% (95% CI: 29.0-96.3). Seven (10%) patients developed complications after the first biopsy and none after the second.
  
  
  CONCLUSIONS
  The diagnostic yield was lower for lesions less than 2cm in size and located superficially. In this series we did not observe an increased rate of complications after a second biopsy.
authors.affiliation: Departamento de Neurocirugía, Hospital Universitario Donostia, San Sebastián, Guipúzcoa, España. Electronic address: lumacara@yahoo.com.
authors.forename: Maria
authors.initials: M
authors.lastname: Castle
authors.affiliation: Departamento de Neurocirugía, Hospital Universitario Donostia, San Sebastián, Guipúzcoa, España.
authors.forename: Edinson
authors.initials: E
authors.lastname: Nájera
authors.affiliation: Departamento de Neurocirugía, Hospital Universitario Donostia, San Sebastián, Guipúzcoa, España.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Samprón
authors.affiliation: Departamento de Neurocirugía, Hospital Universitario Donostia, San Sebastián, Guipúzcoa, España.
authors.forename: Alicia
authors.initials: A
authors.lastname: Bollar
authors.affiliation: Departamento de Neurocirugía, Hospital Universitario Donostia, San Sebastián, Guipúzcoa, España.
authors.forename: Iratxe
authors.initials: I
authors.lastname: Urreta
authors.affiliation: Departamento de Neurocirugía, Hospital Universitario Donostia, San Sebastián, Guipúzcoa, España.
authors.forename: Enrique
authors.initials: E
authors.lastname: Urculo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001706:Biopsy / Q000009:adverse effects / Q000379:methods*; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary; D002277:Carcinoma / Q000175:diagnosis / Q000556:secondary; D003287:Contrast Media / Q000627:therapeutic use; D003711:Demyelinating Diseases / Q000175:diagnosis / Q000473:pathology; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology; D006406:Hematoma / Q000209:etiology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D038361:Neuronavigation / Q000009:adverse effects; D012372:ROC Curve; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology; D012680:Sensitivity and Specificity; D047368:Tumor Burden
chemical_list: D003287:Contrast Media
keywords: Biopsia estereotáctica sin marco; Complicaciones; Complications; Diagnostic yield; Frameless stereotactic biopsy; Rendimiento diagnóstico