title: MIRAGE: the minimum information required for a glycomics experiment.
abstract: The MIRAGE (minimum information required for a glycomics experiment) initiative was founded in Seattle, WA, in November 2011 in order to develop guidelines for reporting the qualitative and quantitative results obtained by diverse types of glycomics analyses, including the conditions and techniques that were applied to prepare the glycans for analysis and generate the primary data along with the tools and parameters that were used to process and annotate this data. These guidelines must address a broad range of issues, as glycomics data are inherently complex and are generated using diverse methods, including mass spectrometry (MS), chromatography, glycan array-binding assays, nuclear magnetic resonance (NMR) and other rapidly developing technologies. The acceptance of these guidelines by scientists conducting research on biological systems in which glycans have a significant role will facilitate the evaluation and reproduction of glycomics experiments and data that is reported in scientific journals and uploaded to glycomics databases. As a first step, MIRAGE guidelines for glycan analysis by MS have been recently published (Kolarich D, Rapp E, Struwe WB, Haslam SM, Zaia J., et al. 2013. The minimum information required for a glycomics experiment (MIRAGE) project - Improving the standards for reporting mass spectrometry-based glycoanalytic data. Mol. Cell Proteomics. 12:991-995), allowing them to be implemented and evaluated in the context of real-world glycobiology research. In this paper, we set out the historical context, organization structure and overarching objectives of the MIRAGE initiative.
authors.affiliation: Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA.
authors.forename: William S
authors.initials: WS
authors.lastname: York
authors.forename: Sanjay
authors.initials: S
authors.lastname: Agravat
authors.forename: Kiyoko F
authors.initials: KF
authors.lastname: Aoki-Kinoshita
authors.forename: Ryan
authors.initials: R
authors.lastname: McBride
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Campbell
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Costello
authors.forename: Anne
authors.initials: A
authors.lastname: Dell
authors.forename: Ten
authors.initials: T
authors.lastname: Feizi
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Haslam
authors.forename: Niclas
authors.initials: N
authors.lastname: Karlsson
authors.forename: Kay-Hooi
authors.initials: KH
authors.lastname: Khoo
authors.forename: Daniel
authors.initials: D
authors.lastname: Kolarich
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Milos
authors.initials: M
authors.lastname: Novotny
authors.forename: Nicolle H
authors.initials: NH
authors.lastname: Packer
authors.forename: James C
authors.initials: JC
authors.lastname: Paulson
authors.forename: Erdmann
authors.initials: E
authors.lastname: Rapp
authors.forename: Rene
authors.initials: R
authors.lastname: Ranzinger
authors.forename: Pauline M
authors.initials: PM
authors.lastname: Rudd
authors.forename: David F
authors.initials: DF
authors.lastname: Smith
authors.forename: Weston B
authors.initials: WB
authors.lastname: Struwe
authors.forename: Michael
authors.initials: M
authors.lastname: Tiemeyer
authors.forename: Lance
authors.initials: L
authors.lastname: Wells
authors.forename: Joseph
authors.initials: J
authors.lastname: Zaia
authors.forename: Carsten
authors.initials: C
authors.lastname: Kettner
mesh_terms: D016208:Databases, Factual / Q000592:standards*; D054794:Glycomics / Q000379:methods* / Q000592:standards*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods / Q000592:standards