title: Effectiveness of tamsulosin in prevention of post-operative urinary retention: a randomized double-blind placebo-controlled study.
abstract: OBJECTIVE
  Urinary retention is one of the most common complications contributing to surgical procedures. Recent studies have shown the benefits of alpha-adrenergic blockers in preventing post-operative urinary retention (POUR). The aim of this prospective study was to compare the prophylactic effect of tamsulosin with placebo on postoperative urinary retention.
  
  
  METHODS
  In this randomized placebo controlled, clinical trial, 232 male patients aged 18 to 50 years old admitted to Razi University Hospital for varicocelectomy, inguinal herniorrhaphy, and scrotal surgery were randomly assigned to receive either three doses of 0.4mg tamsulosin (n = 118) or placebo (n = 114), 14 and 2 hours before, and 10 hours after surgery. Patients were closely monitored for the development of urinary retention 24 hours after surgical intervention. The primary endpoint was to investigate the effect of tamsulosin in prevention of post-operative urinary retention during the first 24 hours after surgical intervention. Collected data were analyzed using SPSS software version 18 and the P < 0.05 was considered statistically significant.
  
  
  RESULTS
  One hundred and eighteen patients were included in tamsulosin arm and 114 in placebo arm. POUR in patients who received tamsulosin was significantly lower than placebo, as 5.9% of the patients treated with tamsulosin and 21.1% placebo group, reported urinary retention following surgery (P = 0.001). No serious adverse effects were seen in both groups.
  
  
  CONCLUSIONS
  This study suggests that short perioperative treatment with tamsulosin can reduce the incidence of urinary retention and the need for catheterization after varicocelectomy, inguinal herniorrhaphy, and scrotal surgery.
authors.affiliation: Urology Research Center, School of Medicine, Guilan University of Medical Sciences.
authors.forename: Ali Hamidi
authors.initials: AH
authors.lastname: Madani
authors.affiliation: Urology Research Center, School of Medicine, Guilan University of Medical Sciences.
authors.forename: Hamidreza Baghani
authors.initials: HB
authors.lastname: Aval
authors.affiliation: Urology Research Center, School of Medicine, Guilan University of Medical Sciences.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Mokhtari
authors.affiliation: Urology Research Center, School of Medicine, Guilan University of Medical Sciences.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Nasseh
authors.affiliation: Urology Research Center, School of Medicine, Guilan University of Medical Sciences.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Esmaeili
authors.affiliation: Urology Research Center, School of Medicine, Guilan University of Medical Sciences.
authors.forename: Maryam
authors.initials: M
authors.lastname: Shakiba
authors.affiliation: Urology Research Center, School of Medicine, Guilan University of Medical Sciences.
authors.forename: Reza Shahrokhi
authors.initials: RS
authors.lastname: Shakiba
authors.affiliation: Urology Research Center, School of Medicine, Guilan University of Medical Sciences.
authors.forename: Seyed Mohamad
authors.initials: SM
authors.lastname: Seyed Damavand
mesh_terms: D000293:Adolescent; D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D000328:Adult; D004311:Double-Blind Method; D059685:Herniorrhaphy / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D011183:Postoperative Complications / Q000188:drug therapy* / Q000517:prevention & control*; D011446:Prospective Studies; D012307:Risk Factors; D012611:Scrotum / Q000601:surgery; D013449:Sulfonamides / Q000627:therapeutic use*; D000077409:Tamsulosin; D013997:Time Factors; D016896:Treatment Outcome; D016055:Urinary Retention / Q000188:drug therapy* / Q000517:prevention & control*; D014646:Varicocele / Q000601:surgery; D055815:Young Adult
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin