title: Fast identification of selective resins for removal of genotoxic aminopyridine impurities via screening of molecularly imprinted polymer libraries.
abstract: This study describes the identification and evaluation of molecularly imprinted polymers (MIPs) for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals. Screening experiments were performed using existing MIP resin libraries to identify resins selective towards those impurities in the presence of model pharmaceutical compounds. A hit resin with a considerable imprinting effect was found in the screening and upon further investigation, the resin was found to show a broad selectivity towards five different aminopyridines in the presence of the two model active pharmaceutical ingredients (APIs) piroxicam and tenoxicam.
authors.affiliation: MIP Technologies AB, A subsidiary of Biotage AB, Box 737, Lund 22007, Sweden. Electronic address: rkecili@anadolu.edu.tr.
authors.forename: Rustem
authors.initials: R
authors.lastname: Kecili
authors.affiliation: MIP Technologies AB, A subsidiary of Biotage AB, Box 737, Lund 22007, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Billing
authors.affiliation: MIP Technologies AB, A subsidiary of Biotage AB, Box 737, Lund 22007, Sweden.
authors.forename: David
authors.initials: D
authors.lastname: Nivhede
authors.affiliation: Malmö University, Faculty of Health and Society, Department of Biomedical Sciences, Malmö 20506, Sweden.
authors.forename: Börje
authors.initials: B
authors.lastname: Sellergren
authors.affiliation: Biotage AB, Box 8, Uppsala 75103, Sweden.
authors.forename: Anthony
authors.initials: A
authors.lastname: Rees
authors.affiliation: MIP Technologies AB, A subsidiary of Biotage AB, Box 737, Lund 22007, Sweden.
authors.forename: Ecevit
authors.initials: E
authors.lastname: Yilmaz
mesh_terms: D000631:Aminopyridines / Q000302:isolation & purification*; D002273:Carcinogens / Q000302:isolation & purification*; D004340:Drug Contamination; D054802:Molecular Imprinting; D009538:Nicotine / Q000031:analogs & derivatives* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010894:Piroxicam / Q000031:analogs & derivatives / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D000631:Aminopyridines; D002273:Carcinogens; D004364:Pharmaceutical Preparations; D011108:Polymers; D010894:Piroxicam; D009538:Nicotine; C005311:nornicotine; C032801:tenoxicam
keywords: Active pharmaceutical ingredients; Aminopyridines; Genotoxic impurities; Molecularly imprinted polymers