title: Tetanus: a diagnostic challenge in the Western world.
abstract: Tetanus is a very serious neuromuscular disease caused by a powerful exotoxin, tetanospasmin, from the Clostridium tetani bacillus. Its incidence in the developed world has diminished considerably since the introduction of primary vaccination. Tetanus is diagnosed clinically, through recognition of the characteristically inducible muscle spasms. Three clinical forms described in adults are generalised, localised and cephalic tetanus. Management of tetanus aims at removing the source of tetanospasmin, neutralising circulating toxin, and providing adequate supportive care for muscle spasms, respiration and autonomic instability. Tetanus is a forgotten disease in developed countries since many practicing primary care physicians have not seen a single case in their career. We present a case of tetanus and review briefly the pathogenesis, clinical features and therapy in order to educate the internist in recognising and adequately treating this disease.
authors.forename: A
authors.initials: A
authors.lastname: Van Driessche
authors.forename: B
authors.initials: B
authors.lastname: Janssens
authors.forename: Y
authors.initials: Y
authors.lastname: Coppens
authors.forename: C
authors.initials: C
authors.lastname: Bachmann
authors.forename: J
authors.initials: J
authors.lastname: Donck
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001247:Asthenia / Q000382:microbiology; D004630:Emergencies; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D012121:Respiration, Artificial / Q000379:methods; D013742:Tetanus / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy*; D013743:Tetanus Antitoxin / Q000008:administration & dosage*; D016896:Treatment Outcome; D014313:Trismus / Q000382:microbiology; D019366:Western World
chemical_list: D000900:Anti-Bacterial Agents; D007155:Immunologic Factors; D013743:Tetanus Antitoxin
keywords: Tetanus,; clostridium tetani,; neurotoxin.; opisthotonus,; trismus,