title: Abnormal lateral geniculate nucleus and optic chiasm in human albinism.
abstract: Our objective was to measure how the misrouting of retinal ganglion cell (RGC) fibers affects the organization of the optic chiasm and lateral geniculate nuclei (LGN) in human albinism. We compared the chiasmal structures and the LGN in both pigmented controls and patients with albinism by using high-resolution structural magnetic resonance imaging (MRI). We studied 12 patients with oculocutaneous albinism and 12 age-matched pigmented controls. Using a 3T MRI scanner, we acquired a T1 -weighted three-dimensional magnetization-prepared rapid gradient-echo (MPRAGE) image of the whole brain, oriented so that the optic nerves, chiasm, and tracts were in the same plane. We acquired multiple proton density-weighted images centered on the thalamus and midbrain, and averaged them to increase the signal, enabling precise manual tracing of the anatomical boundaries of the LGN. Albinism patients exhibited significantly smaller diameters of the optic nerves, chiasm and tracts, and optic chiasm and LGN volume compared with controls (P < 0.001 for all). The reductions in chiasmal diameters in the albinism compared with the control group can be attributed to the abnormal crossing of optic fibers and the reduction of RGCs in the central retina. The volume of the LGN devoted to the center of the visual field may be reduced in albinism due to fewer RGCs representing the area where the fovea would normally lie. Our data may be clinically useful in addressing how genetic deficits compromise proper structural and functional development in the brain.
authors.affiliation: Department of Biology, York University, Toronto, Ontario, Canada; Centre for Vision Research, York University, Toronto, Ontario, Canada.
authors.forename: Larissa
authors.initials: L
authors.lastname: Mcketton
authors.forename: Krista R
authors.initials: KR
authors.lastname: Kelly
authors.forename: Keith A
authors.initials: KA
authors.lastname: Schneider
mesh_terms: D000293:Adolescent; D000328:Adult; D000417:Albinism / Q000473:pathology*; D005260:Female; D005829:Geniculate Bodies / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000473:pathology; D008875:Middle Aged; D009897:Optic Chiasm / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology; D009929:Organ Size; D012160:Retina / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000473:pathology; D013788:Thalamus / Q000473:pathology; D014794:Visual Fields; D014795:Visual Pathways / Q000473:pathology; D055815:Young Adult
keywords: albinism; lateral geniculate nucleus; magnetic resonance imaging; optic chaism