title: Amyloid-hydroxyapatite bone biomimetic composites.
abstract: A "bottom up" strategy is proposed to synthesize high aspect ratio hydroxyapatite (and brushite) platelets, and combine them with amyloid fibrils into layered hybrid nanocomposites. Their hierarchical structure, despite the differences from natural bone, confers to the nanocomposites a density and elastic modulus matching those of cancellous bone. Evidence of good adhesion and spreading of human trabecular bone-derived pre-osteoblasts cells on these nanocomposites is provided.
authors.affiliation: ETH Zurich, Food & Soft Materials, Department of Health Science & Technology, Schmelzbergstrasse 9, LFO, E23, 8092, Zürich, Switzerland.
authors.forename: Chaoxu
authors.initials: C
authors.lastname: Li
authors.forename: Anne-Kathrin
authors.initials: AK
authors.lastname: Born
authors.forename: Thomas
authors.initials: T
authors.lastname: Schweizer
authors.forename: Marcy
authors.initials: M
authors.lastname: Zenobi-Wong
authors.forename: Marta
authors.initials: M
authors.lastname: Cerruti
authors.forename: Raffaele
authors.initials: R
authors.lastname: Mezzenga
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry*; D015519:Bone Density; D001842:Bone and Bones / Q000737:chemistry*; D002448:Cell Adhesion; D018929:Cell Culture Techniques; D002645:Chickens; D017886:Durapatite / Q000737:chemistry*; D004527:Egg Proteins / Q000737:chemistry; D055119:Elastic Modulus; D006801:Humans; D007782:Lactoglobulins / Q000737:chemistry; D009113:Muramidase / Q000737:chemistry; D053761:Nanocomposites / Q000737:chemistry*; D010006:Osteoblasts / Q000378:metabolism; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D000682:Amyloid; D004527:Egg Proteins; D007782:Lactoglobulins; D017886:Durapatite; D009113:Muramidase
keywords: amyloid fibrils; biomimetic materials; bone-mimetic nanocomposites; hydroxyapatite; osteoblast