title: Thromboelastograph with Platelet Mapping(TM) predicts postoperative chest tube drainage in patients undergoing coronary artery bypass grafting.
abstract: OBJECTIVE
  The goal of this study was to evaluate the ability of Thromboelastograph with Platelet Mapping (TEG-PM(TM)) to predict postoperative bleeding tendency in patients with a history of recent anti-platelet therapy undergoing coronary artery bypass grafting (CABG).
  
  
  METHODS
  A retrospective analysis. Association between predictor variables (MAADP [maximum amplitude produced by adenosine diphosphate], MAAA [maximum amplitude produced by arachidonic acid], percent of platelets inhibited by clopidogrel, percent of platelets inhibited by aspirin) and the outcomes as elevated chest tube drainage (CTD) and blood transfusion were investigated by logistic regression model. CTD was considered elevated if it was ≥ 600 mL within 12 hours after surgery.
  
  
  METHODS
  A university hospital.
  
  
  METHODS
  Patients on antiplatelet therapy scheduled to undergo CABG that had TEG-PM(TM) done as a point-of-care test.
  
  
  METHODS
  None.
  
  
  RESULTS
  A total of 78 patients had preoperative TEG-PM(TM) test and on-pump CABG surgeries performed on the same day. Among them, 20 patients (25.6%) had elevated CTD. Decreased MAADP (odds ratio [OR] 0.94), increased percent inhibition of platelets by clopidogrel (OR 1.03), and lower body mass index (BMI) (OR 0.78) were significantly associated with elevated CTD. The same parameters were also associated with platelets transfusion: MAADP (OR 0.94), percent of inhibition of platelets by clopidogrel (OR 1.03) and BMI (OR 0.77).
  
  
  CONCLUSIONS
  TEG-PM(TM) parameters and BMI are predictive of elevated CTD and platelets transfusion. A 1 mm decrease in MAADP increases the likelihood of elevated CTD and the likelihood of platelets transfusion by 6% whereas 1 unit decrease in BMI is associated with an increased likelihood of elevated CTD and platelets transfusion by 22% and 23% respectively.
authors.affiliation: Department of Anesthesiology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx. Electronic address: mohsin.chowdhury@med.einstein.yu.edu.
authors.forename: Mohsin
authors.initials: M
authors.lastname: Chowdhury
authors.affiliation: Department of Anesthesiology, North Shore-Long Island Jewish Medical Center, New Hyde Park, NY.
authors.forename: Linda
authors.initials: L
authors.lastname: Shore-Lesserson
authors.affiliation: A.M.M. assisted with the article as a high school summer student.
authors.forename: Alec M
authors.initials: AM
authors.lastname: Mais
authors.affiliation: Department of Anesthesiology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx.
authors.forename: Galina
authors.initials: G
authors.lastname: Leyvi
mesh_terms: D000244:Adenosine Diphosphate; D000368:Aged; D000465:Algorithms; D001803:Blood Transfusion; D015992:Body Mass Index; D015505:Chest Tubes; D000077144:Clopidogrel; D001026:Coronary Artery Bypass / Q000379:methods*; D004322:Drainage / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D010979:Platelet Function Tests / Q000295:instrumentation*; D019095:Point-of-Care Systems; D019106:Postoperative Hemorrhage / Q000175:diagnosis* / Q000453:epidemiology*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D013916:Thrombelastography / Q000379:methods*; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D000077144:Clopidogrel; D013988:Ticlopidine
keywords: CABG; anti-platelet therapy; platelet mapping; thromboelastography