title: Switching on cilia: transcriptional networks regulating ciliogenesis.
abstract: Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory hubs for a variety of signal transduction pathways. Despite having a conserved basic morphology, cilia vary extensively in their shapes and sizes, ultrastructural details, numbers per cell, motility patterns and sensory capabilities. Emerging evidence indicates that this diversity, which is intimately linked to the different functions that cilia perform, is in large part programmed at the transcriptional level. Here, we review our understanding of the transcriptional control of ciliary biogenesis, highlighting the activities of FOXJ1 and the RFX family of transcriptional regulators. In addition, we examine how a number of signaling pathways, and lineage and cell fate determinants can induce and modulate ciliogenic programs to bring about the differentiation of distinct cilia types.
authors.affiliation: Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673 Singapore.
authors.forename: Semil P
authors.initials: SP
authors.lastname: Choksi
authors.forename: Gilbert
authors.initials: G
authors.lastname: Lauter
authors.forename: Peter
authors.initials: P
authors.lastname: Swoboda
authors.forename: Sudipto
authors.initials: S
authors.lastname: Roy
mesh_terms: D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002923:Cilia / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology; D051858:Forkhead Transcription Factors / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks / Q000502:physiology*; D006801:Humans; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: D029742:Caenorhabditis elegans Proteins; C410596:DAF-19 protein, C elegans; D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors
keywords: Cilia; Ciliogenesis; FOXJ1; Motile cilia; RFX; Transcriptional regulation