title: Metabolomic biomarkers in serum and urine in women with preeclampsia.
abstract: OBJECTIVE
  To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis.
  
  
  METHODS
  Urine and serum samples from pregnant women with preeclampsia (n = 10), normal pregnancies (n = 10) and non-pregnant women (n = 10) matched by age and gestational age were analyzed with MR spectroscopy and subjected to multivariate analysis. Metabolites were then quantified and compared between groups.
  
  
  RESULTS
  Urine and serum samples revealed clear differences between women with preeclampsia and both control groups (normal pregnant and non-pregnant women). Nine urine metabolites were significantly different between preeclampsia and the normal pregnant group. Urine samples from women with early onset preeclampsia clustered together in the multivariate analysis. The preeclampsia serum spectra showed higher levels of low and very-low density lipoproteins and lower levels of high-density lipoproteins when compared to both non-pregnant and normal pregnant women.
  
  
  CONCLUSIONS
  The MR determined metabolic profiles in urine and serum from women with preeclampsia are clearly different from normal pregnant women. The observed differences represent a potential to examine mechanisms underlying different preeclampsia phenotypes in urine and serum samples in larger studies. In addition, similarities between preeclampsia and cardiovascular disease in metabolomics are demonstrated.
authors.affiliation: Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Liaison Committee between the Central Norway Regional Health Authority (RHA) and Norwegian University of Science and Technology (NTNU), Trondheim, Norway; St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Marie
authors.initials: M
authors.lastname: Austdal
authors.affiliation: Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; National Center for Fetal Medicine, St. Olavs Hospital, Trondheim, Norway.
authors.forename: Ragnhild Bergene
authors.initials: RB
authors.lastname: Skråstad
authors.affiliation: Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
authors.forename: Astrid Solberg
authors.initials: AS
authors.lastname: Gundersen
authors.affiliation: Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Centre of Molecular Inflammation Research (CEMIR), Faculty of Medicine, NTNU, Trondheim, Norway.
authors.forename: Rigmor
authors.initials: R
authors.lastname: Austgulen
authors.affiliation: Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Centre of Molecular Inflammation Research (CEMIR), Faculty of Medicine, NTNU, Trondheim, Norway.
authors.forename: Ann-Charlotte
authors.initials: AC
authors.lastname: Iversen
authors.affiliation: Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Tone Frost
authors.initials: TF
authors.lastname: Bathen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D055442:Metabolome; D055432:Metabolomics / Q000379:methods; D019906:Nuclear Magnetic Resonance, Biomolecular; D011225:Pre-Eclampsia / Q000097:blood* / Q000652:urine*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D015415:Biomarkers