title: Comparison of the osteogenic potential of titanium- and modified zirconia-based bioceramics.
abstract: Zirconia is now favored over titanium for use in dental implant materials because of its superior aesthetic qualities. However, zirconia is susceptible to degradation at lower temperatures. In order to address this issue, we have developed modified zirconia implants that contain tantalum oxide or niobium oxide. Cells attached as efficiently to the zirconia implants as to titanium-based materials, irrespective of surface roughness. Cell proliferation on the polished surface was higher than that on the rough surfaces, but the converse was true for the osteogenic response. Cells on yttrium (Y)/tantalum (Ta)- and yttrium (Y)/niobium (Nb)-stabilized tetragonal zirconia polycrystals (TZP) discs ((Y, Ta)-TZP and (Y, Nb)-TZP, respectively) had a similar proliferative potential as those grown on anodized titanium. The osteogenic potential of MC3T3-E1 pre-osteoblast cells on (Y, Ta)-TZP and (Y, Nb)-TZP was similar to that of cells grown on rough-surface titanium. These data demonstrate that improved zirconia implants, which are resistant to temperature-induced degradation, retain the desirable clinical properties of structural stability and support of an osteogenic response.
authors.affiliation: Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul 110-749, Korea. hmryoo@snu.ac.kr.
authors.forename: Young-Dan
authors.initials: YD
authors.lastname: Cho
authors.affiliation: Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul 110-749, Korea. sjcyj@snu.ac.kr.
authors.forename: Ji-Cheol
authors.initials: JC
authors.lastname: Shin
authors.affiliation: Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul 110-749, Korea. kim.haley12@gmail.com.
authors.forename: Hye-Lee
authors.initials: HL
authors.lastname: Kim
authors.affiliation: Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul 110-749, Korea. myagmar.gerelmaa@gmail.com.
authors.forename: Myagmar
authors.initials: M
authors.lastname: Gerelmaa
authors.affiliation: Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul 110-749, Korea. prosthoyoon@gmail.com.
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Yoon
authors.affiliation: Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul 110-749, Korea. hmryoo@snu.ac.kr.
authors.forename: Hyun-Mo
authors.initials: HM
authors.lastname: Ryoo
authors.affiliation: Department of Advanced Materials Engineering, Sejong University, Seoul 143-747, Korea. djkim@sejong.ac.kr.
authors.forename: Dae-Joon
authors.initials: DJ
authors.lastname: Kim
authors.affiliation: Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul 110-749, Korea. proshan@snu.ac.kr.
authors.forename: Jung-Suk
authors.initials: JS
authors.lastname: Han
mesh_terms: D000469:Alkaline Phosphatase / Q000235:genetics; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology*; D024042:Collagen Type I / Q000235:genetics; D015870:Gene Expression / Q000187:drug effects; D051379:Mice; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D015675:Osteocalcin / Q000235:genetics; D010012:Osteogenesis / Q000187:drug effects* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D024042:Collagen Type I; D015675:Osteocalcin; D015040:Zirconium; D014025:Titanium; D000469:Alkaline Phosphatase; C028541:zirconium oxide