title: Influence of adipocytokines and periprostatic adiposity measurement parameters on prostate cancer aggressiveness.
abstract: BACKGROUND
  The relationship between obesity and prostate cancer aggressiveness is controversial in recent studies, partly because BMI is the only generally applied marker of obesity. Our study aimed at evaluating the correlation of periprostatic fat (PF) on magnatic resonance imaging (MRI) and adipocytokines with prostate cancer aggressiveness.
  
  
  METHODS
  A total of 184 patients who underwent radical retropubic prostatectomy (RRP) were analyzed retrospectively; different fat measurements on MRI slices and levels of adipocytokines were compared with the clinical and pathologic factors using SSPS ver.13.0.
  
  
  RESULTS
  The PF rates showed a statistically significant variation (p=0.019, 0.025) among groups, that is to say, more adipose tissue was distributed in periprostatic areas of high risk patients. Logistic regression analysis adjusted for age revealed a statistically association between the PF, the ratio and the risk of having high-risk disease (p=0.031, 0.024). The levels of IL-6, leptin and c-reactive protein (CRP) significantly increased with the aggressiveness of prostate cancer, and also with PF and its ratio. The strongest correlation was seen between IL-6 and PF (Pearson r coefficient=0.67, P<0.001). No association was observed between adipocytokines and BMI.
  
  
  CONCLUSIONS
  Periprostatic adiposity not only affects prostate cancer aggressiveness, but also influences the secretion of adipocytokines. IL-6, PF and CRP have promoting effects on progression of prostate cancer.
authors.affiliation: Department of Urology, The Affiliated Hospital of Qingdao University Medical College, Qingdao, Shandong, China E-mail : zq19825@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Li-Jiang
authors.initials: LJ
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Qi
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Yang
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000273:Adipose Tissue / Q000473:pathology; D050154:Adiposity; D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity; D011467:Prostate / Q000473:pathology* / Q000601:surgery; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies
chemical_list: D054392:Adipokines; C508600:IL6 protein, human; D015850:Interleukin-6; D020738:Leptin; D002097:C-Reactive Protein