title: Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms.
abstract: BACKGROUND
  The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality.
  
  
  METHODS
  This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years.
  
  
  RESULTS
  29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts.
  
  
  CONCLUSIONS
  Kidney impairment might contribute to the increased mortality observed in MPN patients.
authors.affiliation: Department of Hematology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark. Electronic address: axchristensen@gmail.com.
authors.forename: Alexander Sidelmann
authors.initials: AS
authors.lastname: Christensen
authors.affiliation: Quantitative Clinical Pharmacology, Novo Nordisk A/S, Søborg, Denmark.
authors.forename: Jonas Bech
authors.initials: JB
authors.lastname: Møller
authors.affiliation: Department of Hematology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark.
authors.forename: Hans Carl
authors.initials: HC
authors.lastname: Hasselbalch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D015994:Incidence; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000150:complications* / Q000401:mortality*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012189:Retrospective Studies
keywords: Chronic inflammation; Chronic kidney disease; Essential thrombocythemia; Hydroxyurea; Myelofibrosis; Myeloproliferative neoplasms; Polycythemia vera