title: Improvement with infliximab of a disseminated sarcoidosis in a patient with Crohn's disease.
abstract: Sarcoidosis and Crohn's disease are systemic granulomatous disorders affecting the lung and the intestine, respectively, with variable involvement of other organs and are seldom associated. While anti-TNF α is a recognized treatment of Crohn's disease, its usage is discussed in sarcoidosis. A 42-year-old man presented with an 11-year-long history of Crohn's disease; upon discovery of an abnormal chest CT scan the diagnosis of multivisceral sarcoidosis was made and, later, a treatment with an anti-TNF α agent, infliximab, was started, because of worsening Crohn's disease recurrences. CT scan demonstrated net regression of pulmonary opacities and hepatosplenic lesions. Pathologies obtained from the intestinal tract and the bronchi of the patient were, respectively, characteristic of Crohn's disease and sarcoidosis leading to the diagnosis of both diseases. We report a rare case of steroid resistant Crohn's disease associated with multivisceral sarcoidosis, treated successfully by an anti-TNF α agent, infliximab.
authors.affiliation: Hospices Civils de Lyon, 69003 Lyon, France.
authors.forename: Nader
authors.identifier: 0000-0003-2550-7265
authors.initials: N
authors.lastname: Chebib
authors.affiliation: Hospices Civils de Lyon, 69003 Lyon, France ; Université de Lyon, 69007 Lyon, France ; Université Lyon1, 69007 Lyon, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Piégay
authors.affiliation: Hospices Civils de Lyon, 69003 Lyon, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Traclet
authors.affiliation: Hospices Civils de Lyon, 69003 Lyon, France ; Université de Lyon, 69007 Lyon, France ; Université Lyon1, 69007 Lyon, France.
authors.forename: François
authors.initials: F
authors.lastname: Mion
authors.affiliation: Hospices Civils de Lyon, 69003 Lyon, France ; Université de Lyon, 69007 Lyon, France ; Université Lyon1, 69007 Lyon, France ; INRA, UMR754, 69007 Lyon, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mornex