title: Interplay between sepsis and chronic health.
abstract: Severe sepsis is associated with high short-term mortality. Several studies suggest that severe sepsis also worsens health status and increases disability among survivors. As the incidence of severe sepsis increases, and advances in critical care reduce the short-term mortality, the number of individuals who are at risk for poor long-term outcomes will increase. Recent studies suggest that the relationship between sepsis and chronic health may be bidirectional; however, the mechanisms underlying this relationship remain poorly understood. Here we review the epidemiologic studies examining the interplay between sepsis and chronic health and propose a conceptual model, which has implications for preclinical and human study design.
authors.affiliation: The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, University of Pittsburgh, Pittsburgh, PA, USA; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: yendes@upmc.edu.
authors.forename: Sachin
authors.initials: S
authors.lastname: Yende
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Michigan, Center for Clinical Management Research, Ann Arbor VA HSR&D Center of Excellence, Ann Arbor, MI, USA.
authors.forename: Theodore J
authors.initials: TJ
authors.lastname: Iwashyna
authors.affiliation: The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, University of Pittsburgh, Pittsburgh, PA, USA; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Derek C
authors.initials: DC
authors.lastname: Angus
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003422:Critical Care / Q000379:methods; D006801:Humans; D018805:Sepsis / Q000150:complications* / Q000453:epidemiology*; D012931:Social Environment