title: [Connective tissue and inflammation].
abstract: The author summarizes the structure of the connective tissues, the increasing motion of the constituents, which determine the role in establishing the structure and function of that. The structure and function of the connective tissue are related to each other in the resting as well as inflammatory states. It is emphasized that cellular events in the connective tissue are part of the defence of the organism, the localisation of the damage and, if possible, the maintenance of restitutio ad integrum. The organism responds to damage with inflammation, the non specific immune response, as well as specific, adaptive immunity. These processes are located in the connective tissue. Sterile and pathogenic inflammation are relatively similar processes, but inevitable differences are present, too. Sialic acids and glycoproteins containing sialic acids have important roles, and the role of Siglecs is also highlighted. Also, similarities and differences in damages caused by pathogens and sterile agents are briefly summarized. In addition, the roles of adhesion molecules linked to each other, and the whole event of inflammatory processes are presented. When considering practical consequences it is stressed that the structure (building up) of the organism and the defending function of inflammation both have fundamental importance. Inflammation has a crucial role in maintaining the integrity and the unimpaired somato-psychological state of the organism. Thus, inflammation serves as a tool of organism identical with the natural immune response, inseparably connected with the specific, adaptive immune response. The main events of the inflammatory processes take place in the connective tissue.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar III. Belgyógyászati Klinika Budapest Kútvölgyi út 4. 1125.
authors.forename: Lajos
authors.initials: L
authors.lastname: Jakab
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000276:immunology / Q000293:injuries / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D019158:N-Acetylneuraminic Acid / Q000378:metabolism
chemical_list: D019158:N-Acetylneuraminic Acid
keywords: adhesive molecules; adhéziós molekulák; connective tissue; inflammatio; inflammation; kötőszövet; sialic acids; sziálsavak