title: Metabolic planar imaging using 123I-β-methyl-iodophenyl pentadecanoic acid identifies myocardial ischemic memory after intracoronary acetylcholine provocation tests in patients with vasospastic angina.
abstract: The aim of this study was to determine the diagnostic accuracy of early/delayed (123)I-β-methyl-iodophenyl pentadecanoic acid ((123)I-BMIPP) planar images to detect disrupted fatty acid metabolism in patients with vasospastic angina (VSA). Heart-to-mediastinum (H/M) ratios and washout rates were calculated from early and late (15 minutes and 4 hours after tracer injection, respectively) planar (123)I-BMIPP images from 13 hypertensive control individuals (mean age, 69.5 years) and 37 patients with VSA (mean age, 62.8 years) 10.5 (mean) days after administering the intracoronary acetylcholine provocation test. Patients with VSA had significantly lower early H/M and delayed H/M ratios (early; 2.2 ± 0.3 versus 2.7 ± 0.5, P = 0.007; delayed: 1.8 ± 0.3 versus 2.4 ± 0.4, P < 0.001) and significantly greater washout rates (39.8 ± 11.8% versus 29.3 ± 11.7%, P = 0.011) than controls. The overall area under the curve defining the accuracy of diagnostic performance was 0.76 (95% confidence interval (CI): 0.59-0.92) and 0.85 (95% CI, 0.73-0.98) for the early and delayed H/M ratios and 0.74 (95% CI, 0.73-0.90) for washout rates. Planar (123)I-BMIPP imaging can diagnose coronary artery spasm with acceptable diagnostic performance and indicates that the delayed H/M ratio has a powerful ability to assess recent ischemia. This technique might be useful in the face of apparently normal coronary angiographic findings during the subacute and chronic phases after ischemic events.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine.
authors.forename: Kihei
authors.initials: K
authors.lastname: Yoneyama
authors.forename: Yoshihiro J
authors.initials: YJ
authors.lastname: Akashi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kida
authors.forename: Kohei
authors.initials: K
authors.lastname: Ashikaga
authors.forename: Haruki
authors.initials: H
authors.lastname: Musha
authors.forename: Kengo
authors.initials: K
authors.lastname: Suzuki
authors.forename: Tomoo
authors.initials: T
authors.lastname: Harada
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Miyake
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage; D000368:Aged; D003329:Coronary Vasospasm / Q000175:diagnosis* / Q000378:metabolism; D003331:Coronary Vessels; D003937:Diagnosis, Differential; D005227:Fatty Acids; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007269:Injections, Intra-Arterial; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D014665:Vasodilator Agents; C049338:iodofiltic acid; C117025:pentadecanoic acid; D000109:Acetylcholine