title: The potential of pralatrexate as a treatment of peripheral T-cell lymphoma.
abstract: BACKGROUND
  Peripheral T-cell lymphomas (PTCLs) are a group of rare malignancies originating from clonal proliferation of mature, post-thymic T cells that represent 10 - 15% of all non-Hodgkin's lymphomas with poor prognosis and median survival of 1 - 3 years. The standard treatment for PTCL has not yet been identified. Many patients with PTCL are refractory to first-line therapy. The complete response rate ranges from 36 to 66% according to different PTCL subtypes. Furthermore, those who reached a complete or partial response often have a shorter progression-free survival.
  
  
  METHODS
  This paper discusses the potential of pralatrexate , a methotrexate analogue, as a treatment of PTCL. The authors report on the efficacy and safety data of controlled studies and describe the end points of ongoing trials. Pralatrexate was the first drug to obtain FDA approval for the treatment of patients with relapsed or refractory PTCL. However, the European Medicines Agency has refused marketing authorization.
  
  
  CONCLUSIONS
  None of the treatments commonly used today have given satisfactory results. Pralatrexate seems to be one of the most promising agents in the treatment of patients with PTCL. Future efforts should be focused on better understanding the molecular pathogenesis of PTCL and on specific trials for different PTCL subtypes using rational drug combinations that include pralatrexate.
authors.affiliation: University of Modena and Reggio Emilia, Medical Oncology, Department of Diagnostic, Clinical and Public Health Medicine , Modena , Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Dondi
authors.forename: Alessia
authors.initials: A
authors.lastname: Bari
authors.forename: Samantha
authors.initials: S
authors.lastname: Pozzi
authors.forename: Paola
authors.initials: P
authors.lastname: Ferri
authors.forename: Stefano
authors.initials: S
authors.lastname: Sacchi
mesh_terms: D000630:Aminopterin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000639:trends; D005493:Folic Acid Antagonists / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: C418863:10-propargyl-10-deazaaminopterin; D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D000630:Aminopterin