title: Genetic variants in DNA repair pathways and risk of upper aerodigestive tract cancers: combined analysis of data from two genome-wide association studies in European populations.
abstract: DNA repair pathways are good candidates for upper aerodigestive tract cancer susceptibility because of their critical role in maintaining genome integrity. We have selected 13 pathways involved in DNA repair representing 212 autosomal genes. To assess the role of these pathways and their associated genes, two European data sets from the International Head and Neck Cancer Epidemiology consortium were pooled, totaling 1954 cases and 3121 controls, with documented demographic, lifetime alcohol and tobacco consumption information. We applied an innovative approach that tests single nucleotide polymorphism (SNP)-sets within DNA repair pathways and then within genes belonging to the significant pathways. We showed an association between the polymerase pathway and oral cavity/pharynx cancers (P-corrected = 4.45 × 10(-) (2)), explained entirely by the association with one SNP, rs1494961 (P = 2.65 × 10(-) (4)), a missense mutation V306I in the second exon of HELQ gene. We also found an association between the cell cycle regulation pathway and esophagus cancer (P-corrected = 1.48 × 10(-) (2)), explained by three SNPs located within or near CSNK1E gene: rs1534891 (P = 1.27 × 10(-) (4)), rs7289981 (P = 3.37 × 10(-) (3)) and rs13054361 (P = 4.09 × 10(-) (3)). As a first attempt to investigate pathway-level associations, our results suggest a role of specific DNA repair genes/pathways in specific upper aerodigestive tract cancer sites.
authors.affiliation: Inserm, U946, Genetic Variation and Human, Diseases and Université Paris-Diderot, Sorbonne Paris-Cité, UMRS-946, Paris, F-75010, France.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Babron
authors.affiliation: Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.
authors.forename: Rémi
authors.initials: R
authors.lastname: Kazma
authors.affiliation: Department of Genetic Epidemiology, International Agency for Research on Cancer, Lyon, F-69008, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Gaborieau
authors.affiliation: Department of Genetic Epidemiology, International Agency for Research on Cancer, Lyon, F-69008, France.
authors.forename: James
authors.initials: J
authors.lastname: McKay
authors.affiliation: Department of Genetic Epidemiology, International Agency for Research on Cancer, Lyon, F-69008, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.affiliation: Université Paris-Sud, Faculty of Medicine, Villejuif, F-94805, France, CNRS, UMR8200, Genomes and Cancers and Gustave Roussy, Villejuif, F-94805, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Sarasin
authors.affiliation: Inserm, U946, Genetic Variation and Human, Diseases and Université Paris-Diderot, Sorbonne Paris-Cité, UMRS-946, Paris, F-75010, France, Gustave Roussy, Villejuif, F-94805, France simone.benhamou@inserm.fr.
authors.forename: Simone
authors.initials: S
authors.lastname: Benhamou
mesh_terms: D000368:Aged; D000428:Alcohol Drinking / Q000235:genetics; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics*; D045643:DNA Repair Enzymes / Q000235:genetics*; D005060:Europe / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D055106:Genome-Wide Association Study; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012907:Smoking / Q000235:genetics
chemical_list: D045643:DNA Repair Enzymes