title: Diagnostic accuracy and practice effects in the National Alzheimer's Coordinating Center Uniform Data Set neuropsychological battery.
abstract: BACKGROUND
  The Uniform Data Set (UDS) neuropsychological battery is frequently used in clinical studies. However, practice effects, effectiveness as a measure of global cognitive functioning, and detection of mild cognitive impairment have not been examined.
  
  
  METHODS
  A normative total score for the UDS has been developed. Linear discriminant analysis determined classification accuracy in identifying cognitively normal and impaired groups. Practice effects were examined in cognitively normal and cognitively impaired groups.
  
  
  RESULTS
  The total score differentiates between cognitively normal participants and those with dementia, but does not accurately identify individuals with mild cognitive impairment (MCI). Mean total scores for test-exposed participants were significantly higher than test-naive participants in both the normal and MCI groups and were higher, but not significantly so, in the dementia group.
  
  
  CONCLUSIONS
  The total score's classification accuracy discriminates between cognitively normal versus participants who have dementia. The total score appears subject to practice effects.
authors.affiliation: Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Neurology, University of Kentucky, Lexington, KY, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Mathews
authors.affiliation: Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Statistics and Biostatistics, University of Kentucky, Lexington, KY, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Abner
authors.affiliation: Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Statistics and Biostatistics, University of Kentucky, Lexington, KY, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Kryscio
authors.affiliation: Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Neurology, University of Kentucky, Lexington, KY, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Jicha
authors.affiliation: Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Baptist Neurology Center, University of Kentucky, Lexington, KY, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Cooper
authors.affiliation: Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Neurology, University of Kentucky, Lexington, KY, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Smith
authors.affiliation: Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Behavioral Science, University of Kentucky, Lexington, KY, USA.
authors.forename: Allison
authors.initials: A
authors.lastname: Caban-Holt
authors.affiliation: Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Behavioral Science, University of Kentucky, Lexington, KY, USA; Department of Neurology, University of Kentucky, Lexington, KY, USA. Electronic address: fascom@uky.edu.
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Schmitt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis*; D003072:Cognition Disorders / Q000145:classification / Q000209:etiology; D003625:Data Collection / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards / Q000706:statistics & numerical data; D012016:Reference Values; D012044:Regression Analysis; D014481:United States
keywords: Aging; Cognitive testing; Diagnostic accuracy; Longitudinal data; Practice effects