title: Low concentration lidocaine (0.5%) bolus epidurally can initiate fast-onset, effective and safe analgesia for early stage labor.
abstract: There is no consensus on the optimal local anesthetic agent to initiate labor analgesia for patients in active labor. Currently used local anesthetic agents for initiating labor analgesia include 0.25% bupivacaine, 0.5% bupivacaine, 0.2% ropivacaine without or with various types and doses of opioids. All these agents are administered in incremental doses and are relatively "slow onset" in initiation of labor analgesia. We used 0.5% lidocaine 10 ml as the loading dose given as an epidural bolus to initiate epidural analgesia for patients in early stages of labor. We included 32 cases (16 in Lidocaine group and 16 in Bupivacaine group). We found that 0.5% lidocaine is fast-onset, very effective and safe in initiating epidural analgesia for early stage labor.
authors.forename: Henry
authors.initials: H
authors.lastname: Liu
authors.forename: Shanglong
authors.initials: S
authors.lastname: Yao
authors.forename: Frank
authors.initials: F
authors.lastname: Rosinia
mesh_terms: D000293:Adolescent; D000328:Adult; D015360:Analgesia, Epidural / Q000379:methods; D016362:Analgesia, Obstetrical / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects; D002045:Bupivacaine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007747:Labor Stage, First; D008012:Lidocaine / Q000008:administration & dosage* / Q000009:adverse effects; D010865:Pilot Projects; D011247:Pregnancy; D011446:Prospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine; D002045:Bupivacaine