title: Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS-2) study.
abstract: OBJECTIVE
  To examine changes in depressive symptoms and treatment in the first 3 years following bariatric surgery.
  
  
  METHODS
  The longitudinal assessment of bariatric surgery-2 (LABS-2) is an observational cohort study of adults (n = 2,458) who underwent a bariatric surgical procedure at 1 of 10 US hospitals between 2006 and 2009. This study includes 2,148 participants who completed the Beck depression inventory (BDI) at baseline and ≥ one follow-up visit in years 1-3.
  
  
  RESULTS
  At baseline, 40.4% self-reported treatment for depression. At least mild depressive symptoms (BDI score ≥ 10) were reported by 28.3%; moderate (BDI score 19-29) and severe (BDI score ≥30) symptoms were uncommon (4.2 and 0.5%, respectively). Mild-to-severe depressive symptoms independently increased the odds (OR = 1.75; P = 0.03) of a major adverse event within 30 days of surgery. Compared with baseline, symptom severity was significantly lower at all follow-up time points (e.g., mild-to-severe symptomatology was 8.9%, 6 months; 8.4%, 1year; 12.2%, 2 years; 15.6%, 3 years; ps < 0.001), but increased between 1 and 3 years postoperatively (P < 0.01). Change in depressive symptoms was significantly related to change in body mass index (r = 0.42; P < 0001).
  
  
  CONCLUSIONS
  Bariatric surgery has a positive impact on depressive features. However, data suggest some deterioration in improvement after the first postoperative year. LABS-2, #NCT00465829, http://www.clinicaltrials.gov/ct2/show/NCT00465829.
authors.affiliation: Neuropsychiatric Research Institute and the University of North Dakota School of Medicine, Fargo, North Dakota, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Mitchell
authors.forename: Wendy C
authors.initials: WC
authors.lastname: King
authors.forename: Jia-Yuh
authors.initials: JY
authors.lastname: Chen
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Devlin
authors.forename: David
authors.initials: D
authors.lastname: Flum
authors.forename: Luis
authors.initials: L
authors.lastname: Garcia
authors.forename: William
authors.initials: W
authors.lastname: Inabet
authors.forename: John R
authors.initials: JR
authors.lastname: Pender
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Kalarchian
authors.forename: Saurabh
authors.initials: S
authors.lastname: Khandelwal
authors.forename: Marsha D
authors.initials: MD
authors.lastname: Marcus
authors.forename: Beth
authors.initials: B
authors.lastname: Schrope
authors.forename: Gladys
authors.initials: G
authors.lastname: Strain
authors.forename: Bruce
authors.initials: B
authors.lastname: Wolfe
authors.forename: Susan
authors.initials: S
authors.lastname: Yanovski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D050110:Bariatric Surgery / Q000523:psychology*; D015992:Body Mass Index; D003863:Depression / Q000188:drug therapy / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D015431:Weight Loss; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents
keywords: Roux-en-Y gastric bypass; antidepressant medication; depression; laparoscopic adjustable gastric band; severe obesity; treatment; weight loss