title: Atypical MRI features at early onset natalizumab-associated progressive multifocal leukoencephalopathy: a case report.
abstract: We report the case of a woman with natalizumab-treated Multiple Sclerosis (MS) that developed progressive multifocal leukoencephalopathy (PML) with atypical MRI features at early onset. This case shows that PML can have variable radiological patterns in natalizumab-treated MS patients thus expanding the possible MRI patterns at onset in these patients.
authors.affiliation: Neurology Unit, Department of Medicine, S. Anna Hospital, Como, Italy. Electronic address: mirko.piola@hsacomo.org.
authors.forename: Mirko
authors.initials: M
authors.lastname: Piola
authors.affiliation: Neurology Unit, Department of Medicine, S. Anna Hospital, Como, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Di Palma
authors.affiliation: Neurology Unit, Department of Medicine, S. Anna Hospital, Como, Italy.
authors.forename: Nerina
authors.initials: N
authors.lastname: Mascoli
authors.affiliation: Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: Binda
authors.affiliation: Neurology Unit, Department of Medicine, S. Anna Hospital, Como, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Arnaboldi
authors.affiliation: Neurology Unit, Department of Medicine, S. Anna Hospital, Como, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Rezzonico
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D000069442:Natalizumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D007155:Immunologic Factors; D000069442:Natalizumab
keywords: MRI; Natalizumab; Progressive multifocal leukoencephalopathy