title: Effect of oxcarbazepine on background EEG activity and cognition in epilepsy.
abstract: OBJECTIVE
  Cognitive dysfunction related to antiepileptic drugs (AEDs) is an important issue in the management of patients with epilepsy. The aim of the present study was to evaluate relative long-term effects of oxcarbazepine (OXC) on cognition in drug-naive patients with epilepsy.
  
  
  METHODS
  Fifteen drug-naïve epilepsy patients were enrolled. Electroencephalogram (EEG) recordings and neuropsychological (NP) tests were performed before and after OXC monotherapy. The relative power of the discrete frequency bandwas obtained. In addition, interhemispheric and intrahemispheric spectral coherence was also calculated.
  
  
  RESULTS
  NP tests showed significant improvement in visuo-spatial, memory and executive function after OXC treatment. However, neither spectral power nor coherence changed significantly with OXC treatment.
  
  
  CONCLUSIONS
  Our study supports the notion that OXC has no significant cognitive side effect in patients with epilepsy.
authors.affiliation: Department of Neurology, Korea University College of Medicine, Seoul, Korea;
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Department of Neurology, Korea University College of Medicine, Seoul, Korea;
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Song
authors.affiliation: Department of Neurology, Korea University College of Medicine, Seoul, Korea;
authors.forename: Chany
authors.initials: C
authors.lastname: Lee
authors.affiliation: Department of Neurology, Ewha Womans University School of Medicine, and Ewha Medical Research Institute, Seoul, Korea;
authors.forename: Hyang Woon
authors.initials: HW
authors.lastname: Lee
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Seung Bong
authors.initials: SB
authors.lastname: Hong
authors.affiliation: Department of Neurology, Korea University College of Medicine, Seoul, Korea;
authors.forename: Ki-Young
authors.initials: KY
authors.lastname: Jung
keywords: Cognition; Coherence; Epilepsy; Oxcarbazepine; Quantitative EEG