title: Eradication of therapy-resistant cancer cells in gastrointestinal organs.
abstract: Early stages of cancer are curable by surgical removal of the primary lesions, however, more advanced cases are often refractory to therapeutic approaches and are more commonly life-threatening, primarily due to cancer metastasis in gastrointestinal cancers. Such biological events are collectively characterized as tumor heterogeneity, the cause of which is the existence of cancer stem cells. To improve cancer survival, therapy-resistant cancer cells should be eradicated. To this end, recent rapid progress in medical science, such as innovative medical technologies including cancer reprogramming, RNA pharmacology and drug delivery systems, all of which effectively target cancer stem cells, has facilitated this objective.
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy ; Gastroenterological Surgery and.
authors.forename: Shimpei
authors.initials: S
authors.lastname: Nishikawa
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy.
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Konno
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy ; Gastroenterological Surgery and.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hamabe
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy ; Gastroenterological Surgery and.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Hasegawa
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy ; Gastroenterological Surgery and.
authors.forename: Hisataka
authors.initials: H
authors.lastname: Ogawa
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy ; Gastroenterological Surgery and.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kano
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy ; Otorhinolaryngology-Head and Neck Surgery, Osaka University, Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Takahito
authors.initials: T
authors.lastname: Fukusumi
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy ; Gastroenterological Surgery and.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Ohta
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Noguchi
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy ; Gastroenterological Surgery and.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Ozaki
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kudo
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sakai
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy.
authors.forename: Naotsugu
authors.initials: N
authors.lastname: Haraguchi
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy.
authors.forename: Taroh
authors.initials: T
authors.lastname: Satoh
authors.affiliation: Gastroenterological Surgery and.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Doki
authors.affiliation: Gastroenterological Surgery and.
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.affiliation: Departments of Frontier Science for Cancer and Chemotherapy.
authors.forename: Hideshi
authors.initials: H
authors.lastname: Ishii
keywords: cancer stem cell; cancer therapy; gastrointestinal organs