title: Phytochemical investigation of sesquiterpenes from the fruits of Schisandra chinensis and their cytotoxic activity.
abstract: Phytochemical investigation of ethanolic extract from the fruits of Schisandra chinensis led to the isolation of four new sesquiterpenes (1-4); their structures were determined by a combination of NMR (1D and 2D) and MS spectroscopic techniques. In addition, all these isolates were screened for their cytotoxic activities against MCF-7, Caco-2, Hela, Lncap, Hep G2 and MDA-MB231 cancer cell lines. Results indicated that compounds 2 and 3 displayed potent cytotoxic activity against Caco2 cell lines with IC50 values of 17.10 μg/mM and 16.46 μg/mM, respectively.
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
authors.forename: A
authors.initials: A
authors.lastname: Venkanna
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
authors.forename: B
authors.initials: B
authors.lastname: Siva
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
authors.forename: B
authors.initials: B
authors.lastname: Poornima
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
authors.forename: P R Rao
authors.initials: PR
authors.lastname: Vadaparthi
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
authors.forename: K Rajendra
authors.initials: KR
authors.lastname: Prasad
authors.affiliation: Biochemistry Division, National Institute of Nutrition (ICMR), Jamai-Osmania (P.O), Hyderabad 500007, India.
authors.forename: K Ashok
authors.initials: KA
authors.lastname: Reddy
authors.affiliation: Biochemistry Division, National Institute of Nutrition (ICMR), Jamai-Osmania (P.O), Hyderabad 500007, India.
authors.forename: G Bhanu Prakash
authors.initials: GB
authors.lastname: Reddy
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India. Electronic address: suresh@iict.res.in.
authors.forename: K Suresh
authors.initials: KS
authors.lastname: Babu
mesh_terms: D053898:Biosynthetic Pathways; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005638:Fruit / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032141:Schisandra / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D012717:Sesquiterpenes
keywords: Cytotoxic activity; Schisandra chinensis; Schisandraceae; Sesquiterpenes