title: Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
abstract: In this review, the advances in the study of breast cancer molecular classifications and the molecular signatures of the luminal subtypes A and B of breast cancer were summarized. Effective clinical outcomes depend mainly on successful preclinical diagnosis and therapeutic decisions. Over the last few years, the ever-expanding investigations focusing on breast cancer diagnosis and the clinical trials have provided accumulating information on the molecular characteristics of breast cancer. Specifically, among the estrogen receptor (ER)-positive types of breast cancer, the luminal subtype A breast cancer has been shown to exhibit good clinical outcomes with endocrine therapy, whereas the luminal subtype B breast cancer represents the more complicated type, diagnostically as well as therapeutically. Furthermore, even in luminal subtype A breast cancer, the resistance to treatment has become the major limitation for endocrine-based therapy. Accumulating molecular data and further clinical trials may enable more accurate diagnostic and therapeutic decisions. The molecular signatures have emerged as a powerful tool for future diagnosis and therapeutic decisions, although currently available data are limited.
authors.affiliation: College of Biological Science and Biotechnology, Shenyang Agricultural University, Shenyang, Liaoning 110866, P.R. China.
authors.forename: Mei Hong
authors.initials: MH
authors.lastname: Zhang
authors.affiliation: College of Biological Science and Biotechnology, Shenyang Agricultural University, Shenyang, Liaoning 110866, P.R. China.
authors.forename: Hong Tao
authors.initials: HT
authors.lastname: Man
authors.affiliation: College of Biological Science and Biotechnology, Shenyang Agricultural University, Shenyang, Liaoning 110866, P.R. China.
authors.forename: Xiao Dan
authors.initials: XD
authors.lastname: Zhao
authors.affiliation: College of Biological Science and Biotechnology, Shenyang Agricultural University, Shenyang, Liaoning 110866, P.R. China.
authors.forename: Ni
authors.initials: N
authors.lastname: Dong
authors.affiliation: College of Biological Science and Biotechnology, Shenyang Agricultural University, Shenyang, Liaoning 110866, P.R. China.
authors.forename: Shi Liang
authors.initials: SL
authors.lastname: Ma
keywords: breast cancer molecular subtype; estrogen receptor; molecular signature