title: Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the effect of adjunctive topiramate in treating acute mania.
  
  
  METHODS
  In this study which was a double-blinded randomized clinical trial, 46 bipolar patients in manic episode, were treated with lithium carbonate and topiramate versus lithium carbonate and placebo and treatment responses were assessed by Young Mania Rating Scale (YMRS) weekly.
  
  
  RESULTS
  In both intervention and control groups, YMRS score had significant decline after 8 weeks(p < 0.001), but there was no statistically significant difference between the two groups (p = 0.419). The highest score decline was after two weeks. YMRS score at baseline did not have statistically significant difference between the intervention and control groups (p = 0.709).
  
  
  CONCLUSIONS
  This study failed to show antimanic efficacy of adjunctive topiramate in the treatment of those with acute manic.
  
  
  BACKGROUND
  None.
  
  
  BACKGROUND
  URL: http://www.irct.ir.IRCT201110317960N1.
authors.affiliation: Resident, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Mirsepassi
authors.affiliation: Psychiatrist, Associate Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Robabeh
authors.initials: R
authors.lastname: Mazinani
authors.affiliation: Psychiatrist, Associate Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Farbod
authors.initials: F
authors.lastname: Fadai
authors.affiliation: Clinical Psychologist, Assistant Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Alibeigi
authors.affiliation: Psychiatrist, Assistant Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Nazeri Astaneh
keywords: Lithium; Mania; Topiramate; Treatment