title: Assessment of the efficacy of orally administered afoxolaner against Rhipicephalus sanguineus sensu lato.
abstract: Two studies were conducted to confirm that a single oral dose of the novel insecticide/acaricide afoxolaner is efficacious against existing infestations of Rhipicephalus sanguineus sensu lato in dogs and can control re-infestation for up to 35 days. Each study utilized 16 purpose bred adult dogs using a controlled randomized block design. One or two days prior to treatment, all dogs were infested with 50 unfed adult ticks. On Day 0 one group was treated with an oral chewable formulation of afoxolaner at a dose as close as possible to the minimum dose of 2.5mg/kg. Weekly re-infestations with 50 adult unfed ticks were repeated for five weeks. Forty-eight hours after treatment and after each re-infestation, the number of remaining live ticks on each dog was counted. Treatment with afoxolaner resulted in efficacies of 98.8-100% within 48 h on existing tick infestations, while the efficacy against new tick infestations was >95.7% over five weeks.
authors.affiliation: Merial Limited, 3239 Satellite Boulelvard, Duluth, GA 30096, USA. Electronic address: bruce.kunkle@merial.com.
authors.forename: Bruce
authors.initials: B
authors.lastname: Kunkle
authors.affiliation: Merial Limited, 3239 Satellite Boulelvard, Duluth, GA 30096, USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Daly
authors.affiliation: Merial SAS, 29 Avenue Tony Garnier, 69007 Lyon, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumont
authors.affiliation: Merial Limited, 3239 Satellite Boulelvard, Duluth, GA 30096, USA.
authors.forename: Marlene
authors.initials: M
authors.lastname: Drag
authors.affiliation: Merial Limited, 3239 Satellite Boulelvard, Duluth, GA 30096, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Larsen
mesh_terms: D056810:Acaricides / Q000008:administration & dosage*; D000284:Administration, Oral; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000517:prevention & control; D004285:Dogs; D005260:Female; D007555:Isoxazoles / Q000008:administration & dosage*; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage*; D011897:Random Allocation; D048508:Rhipicephalus sanguineus; D013984:Tick Infestations / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D056810:Acaricides; D007555:Isoxazoles; D009281:Naphthalenes; C000589002:afoxolaner
keywords: Afoxolaner; Dog; Oral efficacy; Rhipicephalus sanguineus; Tick