title: Design of novel BSA/hyaluronic acid nanodispersions for transdermal pharma purposes.
abstract: A novel transdermal hyaluronic acid (HA) conjugated with bovine serum albumin (BSA) was developed in the form of solid-in-oil (S/O) nanodispersion (129.7 nm mean diameter). Ex vivo skin penetration analysis by fluorescence and confocal observation of histological skin sections revealed the ability of BSA/HA nanodispersions to cross the stratum corneum and penetrate into the dermis. Furthermore, no significant toxicity was found in fibroblast and keratinocyte cells in vitro. These results proved the potential of the developed nanodispersion for transdermal delivery of hyaluronic acid constituting a high value to biopharmaceutical and cosmetics industries.
authors.affiliation: Centre of Biological Engineering, Universidade do Minho , Campus de Gualtar, 4710-057 Braga, Portugal.
authors.forename: Madalena
authors.initials: M
authors.lastname: Martins
authors.forename: Nuno G
authors.initials: NG
authors.lastname: Azoia
authors.forename: Ulyana
authors.initials: U
authors.lastname: Shimanovich
authors.forename: Teresa
authors.initials: T
authors.lastname: Matamá
authors.forename: Andreia C
authors.initials: AC
authors.lastname: Gomes
authors.forename: Carla
authors.initials: C
authors.lastname: Silva
authors.forename: Artur
authors.initials: A
authors.lastname: Cavaco-Paulo
mesh_terms: D000818:Animals; D002417:Cattle; D002460:Cell Line; D016503:Drug Delivery Systems / Q000009:adverse effects / Q000379:methods*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D049329:Nanostructures / Q000009:adverse effects / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012867:Skin / Q000378:metabolism
chemical_list: D012710:Serum Albumin, Bovine; D006820:Hyaluronic Acid