title: Matricellular proteins and biomaterials.
abstract: Biomaterials are essential to modern medicine as components of reconstructive implants, implantable sensors, and vehicles for localized drug delivery. Advances in biomaterials have led to progression from simply making implants that are nontoxic to making implants that are specifically designed to elicit particular functions within the host. The interaction of implants and the extracellular matrix during the foreign body response is a growing area of concern for the field of biomaterials, because it can lead to implant failure. Expression of matricellular proteins is modulated during the foreign body response and these proteins interact with biomaterials. The design of biomaterials to specifically alter the levels of matricellular proteins surrounding implants provides a new avenue for the design and fabrication of biomimetic biomaterials.
authors.affiliation: Department of Biomedical Engineering, Yale University, New Haven, CT, United States.
authors.forename: Aaron H
authors.initials: AH
authors.lastname: Morris
authors.affiliation: Department of Biomedical Engineering, Yale University, New Haven, CT, United States; Department of Pathology, Yale University, New Haven, CT, United States; Vascular Biology and Therapeutics Program, Yale University, New Haven, CT, United States. Electronic address: themis.kyriakides@yale.edu.
authors.forename: Themis R
authors.initials: TR
authors.lastname: Kyriakides
mesh_terms: D001672:Biocompatible Materials / Q000009:adverse effects*; D055511:CCN Intercellular Signaling Proteins / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005549:Foreign-Body Reaction / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D015676:Osteonectin / Q000378:metabolism; D053495:Osteopontin / Q000378:metabolism; D019063:Tenascin / Q000378:metabolism; D019699:Thrombospondins / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D055511:CCN Intercellular Signaling Proteins; D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D015676:Osteonectin; C512835:POSTN protein, human; C577241:SPARC protein, human; D019063:Tenascin; D019699:Thrombospondins; D053495:Osteopontin
keywords: Biocompatible; Biomaterials; Decellularization; Extracellular matrix; Foreign body response; Matricellular