title: Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial.
abstract: Serum polychlorinated biphenyls (PCBs) in Anniston, AL, residents have been associated with hypertension and diabetes. There have been no systematic interventions to reduce PCB body burdens in Anniston or other populations. Our objective was to determine the efficacy of 15 g/day of dietary olestra to reduce PCBs in Anniston residents. Blood PCBs and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene were measured at baseline and 4-month intervals in a double-blind, placebo-controlled, 1-year trial. Participants with elevated serum PCBs were randomized into two groups of 14 and received potato crisps made with olestra or vegetable oil (VO). Elimination rates during the study period were compared with 5-year prestudy rates. Eleven participants in the olestra group and 12 in the VO group completed the study. Except for one participant in the VO group, reasons for dropout were unrelated to treatments. The elimination rate of 37 non-coplanar PCB congeners during the 1-year trial was faster during olestra consumption compared to the pretrial period (-0.0829 ± 0.0357 and -0.00864 ± 0.0116 year(-1), respectively; P=.04), but not during VO consumption (-0.0413 ± 0.0408 and -0.0283 ± 0.0096 year(-1), respectively; P=.27). The concentration of PCBs in two olestra group participants decreased by 27% and 25% during the trial. There was no significant time by group interaction in change from baseline. However, group main effects for total PCBs and PCB 153 were of borderline significance. This pilot study has demonstrated that olestra can safely reduce body burdens of PCBs and supports a larger intervention trial that may also determine whether reduction in PCBs will reduce the risk of hypertension and diabetes.
authors.affiliation: University of Cincinnati, Cincinnati, Ohio. Electronic address: Ronald.Jandacek@uc.edu.
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Jandacek
authors.affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: James E
authors.initials: JE
authors.lastname: Heubi
authors.affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Donna D
authors.initials: DD
authors.lastname: Buckley
authors.affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Jane C
authors.initials: JC
authors.lastname: Khoury
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Wayman E
authors.initials: WE
authors.lastname: Turner
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Andreas
authors.initials: A
authors.lastname: Sjödin
authors.affiliation: University at Buffalo, Buffalo, New York.
authors.forename: James R
authors.initials: JR
authors.lastname: Olson
authors.affiliation: Jacksonville State University, Jacksonville, Alabama.
authors.forename: Christie
authors.initials: C
authors.lastname: Shelton
authors.affiliation: Jacksonville State University, Jacksonville, Alabama.
authors.forename: Kim
authors.initials: K
authors.lastname: Helms
authors.affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Tina D
authors.initials: TD
authors.lastname: Bailey
authors.affiliation: University of Cincinnati, Cincinnati, Ohio.
authors.forename: Shirley
authors.initials: S
authors.lastname: Carter
authors.affiliation: Jacksonville State University, Jacksonville, Alabama.
authors.forename: Patrick
authors.initials: P
authors.lastname: Tso
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Marian
authors.initials: M
authors.lastname: Pavuk
mesh_terms: D000368:Aged; D000407:Alabama; D001822:Body Burden; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood / Q000493:pharmacokinetics*; D004311:Double-Blind Method; D005227:Fatty Acids / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008939:Mitotane / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics; D010349:Patient Compliance; D010938:Plant Oils / Q000627:therapeutic use*; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000493:pharmacokinetics*; D013395:Sucrose / Q000031:analogs & derivatives* / Q000494:pharmacology; D016896:Treatment Outcome
chemical_list: D005227:Fatty Acids; D010938:Plant Oils; D003633:Dichlorodiphenyl Dichloroethylene; D013395:Sucrose; C013692:sucrose polyester; D008939:Mitotane; D011078:Polychlorinated Biphenyls; C054919:2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene
keywords: Dietary intervention; Olestra; PCBs DDE