title: [Detection rate of Helicobacter pylori and its clinical significance in children with Meckel's diverticulum].
abstract: OBJECTIVE
  To determine the detection rate of Helicobacter pylori (Hp) in children with Meckel's diverticulum (MD) and its clinical significance among children with MD.
  
  
  METHODS
  Eighty-one children with MD were divided into two groups according to the presence (n=45) or absence (n=36) of digestive hemorrhage. The detection rates of Hp in MD tissues and stomach tissues were determined by immunohistochemistry. The detection rates of Hp were compared between the two groups and between the MD tissues with different clinical features in the hemorrhage group.
  
  
  RESULTS
  The detection rate of Hp in MD tissues for the hemorrhage group was 76% (34/45), which was significantly higher than that for the non-hemorrhage group (47%, 17/36) (P<0.05). The detection rate of Hp in stomach tissues for the hemorrhage group (87%, 39/45) was insignificantly higher than that for the non-hemorrhage group (67%, 24/36) (P>0.05). Among patients in the bleeding group, the detection rate of Hp in MD tissues showed no relationship with age, sex, preoperative hemorrhage frequency, amount of hemorrhage, length of MD, basal diameter of MD, and pathological type (P>0.05), but was related to location of MD, presence or absence of ulcer, and depth of ulcer (P<0.05). For the hemorrhage group, a significant positive correlation was found between the detection rates of Hp in MD tissues and stomach tissues (P<0.05), as shown by the Spearman correlation analysis.
  
  
  CONCLUSIONS
  The detection rate of Hp in MD tissues is increased in children with MD complicated by digestive hemorrhage. Hp infection may play some role in the hemorrhage process among children with MD.
authors.affiliation: Department of Gastroenterology, Children's Hospital of Wuhan, Wuhan 430016, China. yishi-mei@163.com.
authors.forename: Shi-Qiong
authors.initials: SQ
authors.lastname: Zhou
authors.forename: Hong
authors.initials: H
authors.lastname: Mei
authors.forename: Xu-Fei
authors.initials: XF
authors.lastname: Duan
authors.forename: Guo-Gang
authors.initials: GG
authors.lastname: Ye
authors.forename: Bao-Xiang
authors.initials: BX
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008467:Meckel Diverticulum / Q000150:complications / Q000382:microbiology*