title: Medical outcomes of adolescent live kidney donors.
abstract: Living kidney donation from donors <18 yr of age is uncommon. The majority of donations from adolescents took place several decades ago providing a unique opportunity to study true long-term consequences of donation. We compared survival, renal outcomes, and rates of hypertension and diabetes among 42 adolescent donors and matched older controls. Adolescent donors were matched with donors 18-30 yr on the following: gender, relation to the recipient, BMI at donation, eGFR at donation, and year of donation. After a mean follow-up of 31.8 ± 8.0 yr, 94.9% of adolescent donors were alive vs. 93.8% of controls. There was no significant difference in having eGFR (MDRD) <60 mL/min/1.73 m(2) (26.1% vs. 40.9%), hypertension (35.9% vs. 39.4%), diabetes (5.1% vs. 12.5%), or proteinuria (15.4% vs. 14.1%): adolescent donors vs. controls for all comparisons. These data suggest that adolescent donors are not at a higher risk of shortened survival, hypertension, diabetes, or proteinuria. Nevertheless, they probably should donate only when other options are exhausted as they have to live with a single kidney for decades and longer follow-up is needed.
authors.affiliation: Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN, USA.
authors.forename: David
authors.initials: D
authors.lastname: MacDonald
authors.forename: Aleksandra K
authors.initials: AK
authors.lastname: Kukla
authors.forename: Sarah
authors.initials: S
authors.lastname: Ake
authors.forename: Danielle
authors.initials: D
authors.lastname: Berglund
authors.forename: Scott
authors.initials: S
authors.lastname: Jackson
authors.forename: Naim
authors.initials: N
authors.lastname: Issa
authors.forename: Richard
authors.initials: R
authors.lastname: Spong
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Matas
authors.forename: Hassan N
authors.initials: HN
authors.lastname: Ibrahim
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003920:Diabetes Mellitus / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation; D019520:Living Donors; D016015:Logistic Models; D008297:Male; D016555:Matched-Pair Analysis; D009392:Nephrectomy / Q000401:mortality*; D063868:Patient Outcome Assessment; D011183:Postoperative Complications / Q000209:etiology*; D011507:Proteinuria / Q000209:etiology; D051437:Renal Insufficiency / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: adolescent; diabetes mellitus; donor; glomerular filtration rate; hypertension; kidney; proteinuria