title: Rapid acquisition technique for MR elastography of the liver.
abstract: Magnetic resonance elastography (MRE) of the liver is a novel noninvasive clinical diagnostic tool to stage fibrosis based on measured stiffness. The purpose of this study is to design, evaluate and validate a rapid MRE acquisition technique for noninvasively quantitating liver stiffness which reduces by half the scan time, thereby decreasing image registration errors between four MRE phase offsets. In vivo liver MRE was performed on 16 healthy volunteers and 14 patients with biopsy-proven liver fibrosis using the standard clinical gradient recalled echo (GRE) MRE sequence (MREs) and a developed rapid GRE MRE sequence (MREr) to obtain the mean stiffness in an axial slice. The mean stiffness values obtained from the entire group using MREs and MREr were 2.72±0.85 kPa and 2.7±0.85 kPa, respectively, representing an insignificant difference. A linear correlation of R(2)=0.99 was determined between stiffness values obtained using MREs and MREr. Therefore, we can conclude that MREr can replace MREs, which reduces the scan time to half of that of the current standard acquisition (MREs), which will facilitate MRE imaging in patients with inability to hold their breath for long periods.
authors.affiliation: Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: Suresh K
authors.initials: SK
authors.lastname: Chamarthi
authors.affiliation: Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Raterman
authors.affiliation: Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Electrical and Computer Engineering, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: Ria
authors.initials: R
authors.lastname: Mazumder
authors.affiliation: Division of Gastroenterology, Hepatology & Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Michaels
authors.affiliation: Division of Gastroenterology, Hepatology & Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: Veeral M
authors.initials: VM
authors.lastname: Oza
authors.affiliation: Division of Gastroenterology, Hepatology & Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: James
authors.initials: J
authors.lastname: Hanje
authors.affiliation: Siemens Medical Solutions Inc., The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: Bradley
authors.initials: B
authors.lastname: Bolster
authors.affiliation: Siemens Medical Solutions Inc., The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: Ning
authors.initials: N
authors.lastname: Jin
authors.affiliation: Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: Richard D
authors.initials: RD
authors.lastname: White
authors.affiliation: Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: arunark.kolipaka@osumc.edu.
authors.forename: Arunark
authors.initials: A
authors.lastname: Kolipaka
mesh_terms: D000328:Adult; D001706:Biopsy; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged
keywords: Liver MRE; Liver fibrosis; MR elastography; MRE