title: Suppressing unwanted memories reduces their unconscious influence via targeted cortical inhibition.
abstract: Suppressing retrieval of unwanted memories reduces their later conscious recall. It is widely believed, however, that suppressed memories can continue to exert strong unconscious effects that may compromise mental health. Here we show that excluding memories from awareness not only modulates medial temporal lobe regions involved in explicit retention, but also neocortical areas underlying unconscious expressions of memory. Using repetition priming in visual perception as a model task, we found that excluding memories of visual objects from consciousness reduced their later indirect influence on perception, literally making the content of suppressed memories harder for participants to see. Critically, effective connectivity and pattern similarity analysis revealed that suppression mechanisms mediated by the right middle frontal gyrus reduced activity in neocortical areas involved in perceiving objects and targeted the neural populations most activated by reminders. The degree of inhibitory modulation of the visual cortex while people were suppressing visual memories predicted, in a later perception test, the disruption in the neural markers of sensory memory. These findings suggest a neurobiological model of how motivated forgetting affects the unconscious expression of memory that may be generalized to other types of memory content. More generally, they suggest that the century-old assumption that suppression leaves unconscious memories intact should be reconsidered.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale and Centre Hospitalier Universitaire, Unité 1077, 14033 Caen, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Gagnepain
authors.forename: Richard N
authors.initials: RN
authors.lastname: Henson
authors.forename: Michael C
authors.initials: MC
authors.lastname: Anderson
mesh_terms: D000328:Adult; D001519:Behavior; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D014473:Unconscious, Psychology; D014793:Visual Cortex / Q000502:physiology; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult
keywords: dynamic causal modeling; inhibitory control; repetition suppression; representational dissimilarity analysis; think/no-think