title: Superimposed lateralized exanthem of childhood: report of a case related to adenovirus infection.
abstract: A 6-year-old boy developed a unilateral itchy rash, which was followed by a less severe bilateral involvement. The lesions resolved spontaneously within 4 weeks. Apparently, the rash was triggered by an adenovirus infection of the respiratory tract. Terms used currently for this disorder include 'unilateral laterothoracic exanthem' or 'asymmetrical periflexural exanthem of childhood'. The recently proposed term 'superimposed lateralized exanthem of childhood' implies the new concept that an early postzygotic mutation has rendered the skin on one side of the body more reactive to infective agents. The subsequent bilateral involvement would reflect a less severe reactivity of the contralateral keratinocytes.
authors.affiliation: Department of Dermatology and Allergology, Ludwig-Maximilian University, Munich, Germany; Landeshauptstadt München, Referat für Gesundheit und Umwelt, Munich, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Niedermeier
authors.forename: W
authors.initials: W
authors.lastname: Pfützner
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
authors.forename: P
authors.initials: P
authors.lastname: Thomas
authors.forename: R
authors.initials: R
authors.lastname: Happle
mesh_terms: D000257:Adenoviridae Infections / Q000150:complications*; D002648:Child; D005076:Exanthema / Q000209:etiology*; D006801:Humans; D008297:Male; D012075:Remission, Spontaneous; D012141:Respiratory Tract Infections / Q000150:complications