title: Hyperthermic intraperitoneal chemoperfusion in combined treatment of locally advanced and disseminated gastric cancer: results of a single-centre retrospective study.
abstract: BACKGROUND
  Patients with locally advanced gastric cancer (GC) and/or peritoneal metastases have a poor prognosis despite systemic chemotherapy or palliative surgery. The aim of this retrospective comparative non-randomised study was to evaluate aggressive cytoreduction in combination with hyperthermic intraperitoneal chemoperfusion (HIPEC) as a novel treatment strategy for patients with intraperitoneal disseminated and locally advanced GC.
  
  
  METHODS
  Forty-nine GC patients with serosal invasion (n = 19), limited peritoneal metastases (n = 20), or disseminated peritoneal metastases and tense ascites (n = 10) underwent combination therapy with HIPEC. Three matched control groups undergoing standard therapies were retrospectively identified.
  
  
  RESULTS
  Combination therapy for serosa-invasive GC reduced the level of metachronous peritoneal carcinomatosis and increased median survival from 12 months to 22.5 months (p = 0.001). The median and 1-year survival rates for intraperitoneal disseminated GC patients undergoing therapy with the use of HIPEC were 12 months and 68.8% compared with 8 months and 25%, respectively (p = 0.004) for control subgroup patients (palliative chemotherapy). The symptomatic use of HIPEC allows effective elimination of recurrent ascites in GC patients.
  
  
  CONCLUSIONS
  HIPEC is a well-tolerated and effective method of adjuvant therapy for gastric cancer with high risk of intraperitoneal progression. Cytoreduction followed by HIPEC improves survival in patients with limited peritoneal carcinomatosis of gastric origin.
authors.affiliation: Department of Oncology and Medical Radiology, Danylo Halytsky Lviv National Medical University , Lviv , Ukraine and.
authors.forename: Roman Romanovych
authors.initials: RR
authors.lastname: Yarema
authors.forename: Myron A
authors.initials: MA
authors.lastname: Ohorchak
authors.forename: Gennadyi P
authors.initials: GP
authors.lastname: Zubarev
authors.forename: Yuriy P
authors.initials: YP
authors.lastname: Mylyan
authors.forename: Yuriy Y
authors.initials: YY
authors.lastname: Oliynyk
authors.forename: Mykola G
authors.initials: MG
authors.lastname: Zubarev
authors.forename: Petro I
authors.initials: PI
authors.lastname: Gyrya
authors.forename: Yuriy J
authors.initials: YJ
authors.lastname: Kovalchuk
authors.forename: Victor I
authors.initials: VI
authors.lastname: Safiyan
authors.forename: Taras G
authors.initials: TG
authors.lastname: Fetsych
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents