title: Biochemical changes following succinylcholine administration after pretreatment with rocuronium at different intervals.
abstract: OBJECTIVE
  To evaluate the biochemical changes associated with succinylcholine administration after pretreatment with rocuronium at different time intervals.
  
  
  METHODS
  The prospective, randomised, single-blinded study was conducted at the Combined Military Hospital, Rawalpindi, from January to May 2010. Ninety male, aged 18-60 years, American Society of Anaesthesiology I or II patients undergoing elective inguinal herniotomy or external haemorrhoidectomy were included. The patients were randomly divided into three equal groups. Group A received a normal saline 5 ml as placebo 1 minute before succinylcholine; Group B received rocuronium 0.06 mg/kg 1 intravenously minute before succinylcholine, while Group C received intravenous injection of rocuronium 0.06 mg/kg 5 minute before succinylcholine. Venous blood samples for creatinine phosphokinase, lactate dehydrogenase and myoglobin plasma concentrations were obtained at 0, 30 minutes, 6 hours and 24 hours after succinylcholine administration.
  
  
  RESULTS
  Mean serum creatinine phosphokinase and myoglobin concentrations were significantly decreased in Groups B and C compared to Group A at 30 minutes and 24 hours (p < 0.05). However, no significant difference in the enzyme levels at any time interval was observed among the rocuronium groups. There was a significant rise in lactate dehydrogenase concentrations at 6 hours and 24 hours in Group A compared to Groups B and C (p < 0.05).
  
  
  CONCLUSIONS
  Pretreatment with rocuronium effectively reduces the biochemical changes associated with succinylcholine-induced muscle fasciculations. However, whether it is given 1 minute or 5 minutes before succinylcholine does not make much difference.
authors.forename: Kulsoom
authors.initials: K
authors.lastname: Farhat
authors.forename: Anwar Kamal
authors.initials: AK
authors.lastname: Pasha
authors.forename: Nusrat
authors.initials: N
authors.lastname: Jaffery
mesh_terms: D000293:Adolescent; D000328:Adult; D000732:Androstanols / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005207:Fasciculation / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D005500:Follow-Up Studies; D006552:Hernia, Inguinal / Q000097:blood / Q000601:surgery; D059685:Herniorrhaphy; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood; D009467:Neuromuscular Depolarizing Agents / Q000008:administration & dosage; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage; D011292:Premedication / Q000379:methods*; D011446:Prospective Studies; D000077123:Rocuronium; D016037:Single-Blind Method; D013390:Succinylcholine / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000732:Androstanols; D015415:Biomarkers; D009211:Myoglobin; D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents; D003402:Creatine Kinase; D013390:Succinylcholine; D000077123:Rocuronium