title: Kindlin-3 in the immune system.
abstract: Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system. Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes. Here, we review the role of kindlin-3 in integrin activation and in different immune cell functions.
authors.affiliation: Institute of Biotechnology, University of Helsinki Finland ; Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee UK.
authors.forename: Susanna C
authors.initials: SC
authors.lastname: Fagerholm
authors.affiliation: Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee UK.
authors.forename: Hwee San
authors.initials: HS
authors.lastname: Lek
authors.affiliation: Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee UK.
authors.forename: Vicky L
authors.initials: VL
authors.lastname: Morrison
keywords: Kindlin; LAD-III; T cell; adhesion; integrin