title: Prooxidant-antioxidant balance and hs-CRP in patients with beta-thalassemia major.
abstract: BACKGROUND
  Beta-thalassemia major is one of the most frequent hemoglobinopathies in the world. This is a study on the levels of prooxidant-antioxidant balance (PAB) that can measure the pro-oxidant burden and the anti-oxidant capacity simultaneously in one assay, giving a redox index, as well as an assessment of high-sensitivity C-reactive protein (hs-CRP) in patients with beta-thalassemia major. It also determines the impact both on kidney function tests.
  
  
  METHODS
  Ninety subjects with beta-thalassemia major (betaTM) and 90 more healthy subjects as the control group were enrolled in the study. Laboratory parameters, serum hs-CRP, and the novel assay of prooxidant-antioxidant balance were measured.
  
  
  RESULTS
  Biochemical and hematological variables, except MCHC, were significantly decreased in patients. Ferritin (p < 0.001) and PAB (p < 0.001) values were statistically increased in patients, whereas hs-CRP (p > 0.05) did not significantly increase in patients. Spearman's correlation univariate analysis showed no significant correlation between PAB with hs-CRP or ferritin. However, there was a significant statistical correlation between hs-CRP with creatinine and triglycerides. Also we found a slight and negative correlation between high-density lipoprotein cholesterol, hemoglobin, and hemotocrit with inflammatory factor.
  
  
  CONCLUSIONS
  Briefly, we found higher levels of PAB values and a slight increase in hs-CRP concentration in patients, which may be involved in the pathological consequences of beta-thalassemia major and contribute to the gradual development of injury to the organs.
authors.forename: Hassan
authors.initials: H
authors.lastname: Ehteram
authors.forename: Mehrnoosh Shanaki
authors.initials: MS
authors.lastname: Bavarsad
authors.forename: Mehdi
authors.initials: M
authors.lastname: Mokhtari
authors.forename: Najmaldin
authors.initials: N
authors.lastname: Saki
authors.forename: Masuod
authors.initials: M
authors.lastname: Soleimani
authors.forename: Seyed Mohammad Reza
authors.initials: SM
authors.lastname: Parizadeh
authors.forename: Naser
authors.initials: N
authors.lastname: Mobarra
mesh_terms: D000375:Aging / Q000097:blood; D000975:Antioxidants / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D016877:Oxidants / Q000097:blood / Q000378:metabolism*; D055815:Young Adult; D017086:beta-Thalassemia / Q000097:blood / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D016877:Oxidants; D002097:C-Reactive Protein; D005293:Ferritins