title: Privileged s-triazines: structure and pharmacological applications.
abstract: This review summarizes recent reports on s-triazine and its respective analogs from the medicinal chemistry angle. Due to its high reactivity and binding characteristic towards various enzymes, s-triazine has attracted attention. This is combined with facile synthesis and interesting pharmacology. The triazine class demonstrates wide biological applications - including antimicrobial, antituberculosis, anticancer, antiviral and antimalarial. In this article the library of s-triazine-based molecular designs has been collated with respective bioactivity. Compounds are further compared with other heterocyclic/nontriazine moieties to correlate the efficiency of privileged s-triazine. We hope this article may assist chemists in their drug design and discovery efforts.
authors.affiliation: Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad - 380 009, Gujarat, India.
authors.forename: Dhruvin R
authors.initials: DR
authors.lastname: Shah
authors.forename: Rahul P
authors.initials: RP
authors.lastname: Modh
authors.forename: Kishor H
authors.initials: KH
authors.lastname: Chikhalia
mesh_terms: D000682:Amyloid / Q000037:antagonists & inhibitors / Q000378:metabolism; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D005658:Fungi / Q000187:drug effects; D006801:Humans; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000682:Amyloid; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D014227:Triazines