title: Correlation of pulmonary function indexes determined by low-dose MDCT with spirometric pulmonary function tests in patients with chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  The objective of our study was to evaluate the correlation between pulmonary function indexes determined by low-dose MDCT and those obtained from routine spirometric pulmonary function tests (PFTs) in patients with chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  Lung function of patients with COPD stages 0-III was evaluated by both MDCT and spirometric PFTs. Scanning was performed at maximum end-inspiration and maximum end-expiration.
  
  
  RESULTS
  A very strong correlation was found between extrapolated expiratory lung volume (LVex) and COPD stage (r = 0.802, p < 0.001) and between extrapolated LVex and the ratio of forced expiratory volume in 1 second and percentage forced vital capacity (FEV1/FVC%) (r = -0.831, p < 0.001). Moreover, strong positive correlations were found between inspiratory lung volume (LVin) and total lung capacity (TLC) (r = 0.658, p < 0.001), LVex and residual volume (RV) (r = 0.683, p < 0.001), extrapolated LVex and RV (r = 0.640, p < 0.001), LVex and RV/TLC (r = 0.602, p < 0.001), LVex/LVin and RV/TLC (r = 0.622, p < 0.001), extrapolated LVex and RV/TLC (r = 0.663, p < 0.001), and LVex and COPD stage (r = 0.697, p < 0.001).
  
  
  CONCLUSIONS
  Low-dose MDCT lung function indexes correlate well with spirometric PFT results, and the highest correlation is at end-expiration. Low-dose MDCT may be useful for evaluating lung function in patients with COPD.
authors.affiliation: 1 Department of Radiology, the First Affiliated Hospital of Guangzhou Medical University, No. 151, Yan Jiang Rd, Yuexiu District, Guangzhou City, Guangdong Province 510120, China.
authors.forename: Huai
authors.initials: H
authors.lastname: Chen
authors.forename: Rong-chang
authors.initials: RC
authors.lastname: Chen
authors.forename: Yu-bao
authors.initials: YB
authors.lastname: Guan
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.forename: Qin
authors.initials: Q
authors.lastname: Liu
authors.forename: Qing-si
authors.initials: QS
authors.lastname: Zeng
mesh_terms: D000368:Aged; D000465:Algorithms; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011829:Radiation Dosage; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D013147:Spirometry