title: The A4 study: stopping AD before symptoms begin?
abstract: A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer's disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline.
authors.affiliation: Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Reisa A
authors.initials: RA
authors.lastname: Sperling
authors.forename: Dorene M
authors.initials: DM
authors.lastname: Rentz
authors.forename: Keith A
authors.initials: KA
authors.lastname: Johnson
authors.forename: Jason
authors.initials: J
authors.lastname: Karlawish
authors.forename: Michael
authors.initials: M
authors.lastname: Donohue
authors.forename: David P
authors.initials: DP
authors.lastname: Salmon
authors.forename: Paul
authors.initials: P
authors.lastname: Aisen
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D000682:Amyloid / Q000037:antagonists & inhibitors*; D006801:Humans
chemical_list: D000682:Amyloid