title: Differential expression and anti-oxidant function of glutathione peroxidase 3 in mouse uterus during decidualization.
abstract: Glutathione peroxidase 3 (GPX3) is an important member of antioxidant enzymes for reducing reactive oxygen species and maintaining the oxygen balance. Gpx3 mRNA is strongly expressed in decidual cells from days 5 to 8 of pregnancy. After pregnant mice are treated with GPX inhibitor for 3 days, pregnancy rate is significantly reduced. Progesterone stimulates Gpx3 expression through PR/HIF1α in mouse endometrial stromal cells. In the decidua, the high level of GPX3 expression is closely associated with the reduction of hydrogen peroxide (H2O2). Based on our data, GPX3 may play a major role in reducing H2O2 during decidualization.
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; School of Life Science, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Xu
authors.affiliation: School of Life Science, Xiamen University, Xiamen 361005, China.
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Leng
authors.affiliation: School of Life Science, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.affiliation: School of Life Science, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Zhen-Ao
authors.initials: ZA
authors.lastname: Zhao
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Deng
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
authors.forename: Xiao-Huan
authors.initials: XH
authors.lastname: Liang
authors.affiliation: School of Life Science, Xiamen University, Xiamen 361005, China.
authors.forename: Yi-Juan
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: School of Life Science, Xiamen University, Xiamen 361005, China.
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Zhang
authors.affiliation: School of Life Science, Xiamen University, Xiamen 361005, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Reproductive Medicine Center, Bailu Hospital, Xiamen 361000, China.
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Sha
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: zmyang@scau.edu.cn.
authors.forename: Zeng-Ming
authors.initials: ZM
authors.lastname: Yang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D015687:Cell Hypoxia; D003338:Corpus Luteum / Q000187:drug effects; D003656:Decidua / Q000201:enzymology* / Q000502:physiology; D010064:Embryo Implantation; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D005979:Glutathione Peroxidase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D051379:Mice; D010084:Oxidation-Reduction; D011247:Pregnancy; D011374:Progesterone / Q000502:physiology; D064586:Selenic Acid / Q000494:pharmacology; D013870:Thiomalates / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D000975:Antioxidants; C497443:Hif1a protein, mouse; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D013870:Thiomalates; D011374:Progesterone; C046062:2-thiomalic acid; D006861:Hydrogen Peroxide; C116888:Gpx3 protein, mouse; D005979:Glutathione Peroxidase; D064586:Selenic Acid
keywords: Decidualization; Gpx3; Implantation; Progesterone; Uterus