title: [Impact of dynamic IMRT and tomotherapy in pelvic cancers: a prospective dosimetric study with 51 patients].
abstract: OBJECTIVE
  To compare the dosimetric results of different techniques of dynamic intensity modulated radiation therapy (IMRT) in patients treated for a pelvic cancer with nodal irradiation.
  
  
  METHODS
  Data of 51 patients included prospectively in the Artpelvis study were analyzed. Thirty-six patients were treated for a high-risk prostate cancer (13 with helical tomotherapy, and 23 with Rapid'Arc(®)) and 15 patients were treated for a localized anal cancer (nine with helical tomotherapy and six with Rapid'Arc(®)). Plan quality was assessed according to several different dosimetric indexes of coverage of planning target volume and sparing of organs at risk.
  
  
  RESULTS
  Although some dosimetric differences were statistically significant, helical tomotherapy and Rapid'Arc provided very similar and highly conformal plans. Regarding organs at risk, Rapid'Arc(®) provided better pelvic bone sparing with a lower non-tumoral integral dose.
  
  
  CONCLUSIONS
  In pelvis cancer with nodal irradiation, Rapid'Arc and helical tomotherapy provided very similar plans. The clinical evaluation of Artpelvis study will verify this equivalence hypothesis.
authors.affiliation: Service de radiothérapie, hôpital universitaire Jean-Minjoz, 3, boulevard Alexandre-Fleming, 25030 Besançon, France; Informatics and radiation physics for medical and technical applications (Irma), LCPR, AC/CE, UMR 6249, CNRS, 4, place Tharradin, BP 71427, 25211 Montbéliard cedex, France; UMR 6249, université de Franche-Comté, 4, place Tharradin, BP 71427, 25211 Montbéliard, France. Electronic address: stephanie.servagi@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Servagi-Vernat
authors.affiliation: Service d'oncologie-radiothérapie, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, Paris Sorbonne Cité, 20, rue Leblanc, 75015 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Giraud
authors.affiliation: Département de radiothérapie, centre Val-d'Aurelle-Paul-Lamarque, 208, rue des Apothicaires, 34298 Montpellier cedex 5, France.
authors.forename: P
authors.initials: P
authors.lastname: Fenoglietto
authors.affiliation: Département de radiothérapie, centre Val-d'Aurelle-Paul-Lamarque, 208, rue des Apothicaires, 34298 Montpellier cedex 5, France.
authors.forename: D
authors.initials: D
authors.lastname: Azria
authors.affiliation: Service de radiothérapie, institut de cancérologie de l'Ouest René-Gauducheau, boulevard Jacques-Monod, 44805 Saint-Herblain, France.
authors.forename: A
authors.initials: A
authors.lastname: Lisbona
authors.affiliation: Département de radiothérapie, institut Curie, 26, rue d'Ulm, 75248 Paris cedex 5, France.
authors.forename: A
authors.initials: A
authors.lastname: de La Rochefordière
authors.affiliation: Département de radiothérapie, institut Curie, 26, rue d'Ulm, 75248 Paris cedex 5, France.
authors.forename: S
authors.initials: S
authors.lastname: Zefkili
authors.affiliation: Institut Paoli-Calmette, 232, boulevard Sainte-Marguerite, 13009 Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Fau
authors.affiliation: Institut Paoli-Calmette, 232, boulevard Sainte-Marguerite, 13009 Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Resbeut
authors.affiliation: Service de radiothérapie, institut de cancérologie de Lorraine, 6, avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.
authors.forename: S
authors.initials: S
authors.lastname: Huger
authors.affiliation: Service de radiothérapie, institut de cancérologie de Lorraine, 6, avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.
authors.forename: D
authors.initials: D
authors.lastname: Peiffert
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-De-l'Hôpital, BP 42, 67065 Strasbourg, France.
authors.forename: P
authors.initials: P
authors.lastname: Meyer
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-De-l'Hôpital, BP 42, 67065 Strasbourg, France.
authors.forename: G
authors.initials: G
authors.lastname: Noël
authors.affiliation: Groupe Oncorad Garonne, clinique Pasteur, l'Atrium, 1, rue de la Petite-Vitesse, 31300 Toulouse, France.
authors.forename: J
authors.initials: J
authors.lastname: Mazurier
authors.affiliation: Groupe Oncorad Garonne, clinique Pasteur, l'Atrium, 1, rue de la Petite-Vitesse, 31300 Toulouse, France.
authors.forename: I
authors.initials: I
authors.lastname: Latorzeff
authors.affiliation: Département de radiothérapie, centre Léon-Bérard, 28, rue Laennec, 69008 Lyon cedex, France.
authors.forename: M-C
authors.initials: MC
authors.lastname: Biston
authors.affiliation: Département de radiothérapie, centre Léon-Bérard, 28, rue Laennec, 69008 Lyon cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Pommier
authors.affiliation: Service d'oncologie-radiothérapie, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, Paris Sorbonne Cité, 20, rue Leblanc, 75015 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Ledu
authors.affiliation: Service de radiothérapie, institut Sainte-Catherine, 1750, chemin du Lavarin, 84000 Avignon, France.
authors.forename: R
authors.initials: R
authors.lastname: Garcia
authors.affiliation: Service de radiothérapie, institut Sainte-Catherine, 1750, chemin du Lavarin, 84000 Avignon, France.
authors.forename: B
authors.initials: B
authors.lastname: Chauvet
authors.affiliation: Service de radiothérapie, clinique Pont-de-Chaume, 330, rue Marcel-Unal, 82000 Montauban, France.
authors.forename: P
authors.initials: P
authors.lastname: Dudouet
authors.affiliation: Service de radiothérapie, institut Bergonié, 229, cours de l'Argonne, 33076 Bordeaux cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Belhomme
authors.affiliation: Service de radiothérapie, institut Bergonié, 229, cours de l'Argonne, 33076 Bordeaux cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Kantor
authors.affiliation: Service de radiothérapie, institut de cancérologie de l'Ouest René-Gauducheau, boulevard Jacques-Monod, 44805 Saint-Herblain, France.
authors.forename: M-A
authors.initials: MA
authors.lastname: Mahé
mesh_terms: D001005:Anus Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008198:Lymph Nodes / Q000528:radiation effects; D008297:Male; D015233:Models, Statistical; D059351:Organ Sparing Treatments; D058958:Organs at Risk; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated
keywords: Comparaison dosimétrique; Dosimetric comparison; Dynamic IMRT; Pelvic radiotherapy; RCMI rotationnelle; Radiothérapie pelvienne; Rapid’Arc(®); Tomotherapy; Tomothérapie hélicoïdale