title: Comparison of albumin and cabergoline in the prevention of ovarian hyperstimulation syndrome: A clinical trial study.
abstract: BACKGROUND
  Ovarian hyperstimulation syndrome (OHSS) is the most serious and potentially life-threatening iatrogenic complication associated with ovarian stimulation during Assisted Reproductive Technology (ART) protocols. OHSS typically is a result of ovarian expression of vascular endothelial growth factor (VEGF) which increases vascular permeability.
  
  
  OBJECTIVE
  Comparison of albumin and cabergoline in the prevention of OHSS.
  
  
  METHODS
  95 high risk infertile women for OHSS (more than 20 follicles in both ovaries at day of Human Chorionic Gonadotropin (HCG) injection) were randomly divided into two groups. First group including 48 women received 10 unit intravenous albumin at starting oocyte retrieval, and second group including 47 women received 0.5 mg/day dopamine agonist (Cabergolin) at day of HCG injection till 8 days. The dosage of human Menopausal Gonadotropin (HMG) used, total number of follicles developed, number of oocytes retrieved, serum E2 concentrations during the luteal phase, development of ascites, number of embryos generated, clinical pregnancy rate, results of the in vitro fertilization-embryo transfer (IVF-ET) cycles and incidence and severity of any OHSS were evaluated.
  
  
  RESULTS
  There was evidence of a statistically significant reduction in the incidence of OHSS in the cabergolin group (53.7%) versus albumin group (46.3%) (p=0.04). But there was no significant difference of a reduction in severe OHSS (p=0.62). There was no difference in clinical pregnancy rate too.
  
  
  CONCLUSIONS
  Administration of cabergolin can prevent incidence of OHSS and does not appear to effect on its severity.
  
  
  BACKGROUND
  IRCT138706281217N4.
authors.affiliation: Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Aalie
authors.initials: A
authors.lastname: Torabizadeh
authors.affiliation: Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Vahidroodsari
authors.affiliation: Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Zakieh
authors.initials: Z
authors.lastname: Ghorbanpour
keywords: Albumin; Assistedreproductivetechnology(ART); Cabergolin; Ovarianhyperstimulationsyndrome (OHSS)