title: Online Kt/V monitoring in haemodialysis by UV absorbance: variations during intra-dialytic meals.
abstract: OBJECTIVE
  The aim of this study was to analyse if intra-dialytic food intake may lead to changes in online Kt/V.
  
  
  METHODS
  Forty patients were analysed using haemodialysis machines with integrated online Kt/V monitoring based on UV absorbance or ionic dialysance. Kt/V was monitored before, during and after food intake. Samples of dialysate were analysed for urea, uric acid, creatinine and glucose levels.
  
  
  RESULTS
  Food intake was associated with a significant decrease in relative Kt/V when determined by UV absorbance. The drop in Kt/V was independent of changes in blood pressure or body posture. No significant changes in online Kt/V were found using the ionic dialysance method. Dialysate samples showed a continuous clearance of urea, uric acid and creatinine during meals but a rapid increase in glucose.
  
  
  CONCLUSIONS
  Our data suggest that the short meal-associated decrease in online Kt/V as measured by UV absorbance does not represent a true decline in Kt/V but might reflect an intermittent increase in UV-absorbing dialysed solutes.
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Hannover Medical School, Hannover, Germany.
authors.forename: Janina
authors.initials: J
authors.lastname: Müller-Deile
authors.forename: Ralf
authors.initials: R
authors.lastname: Lichtinghagen
authors.forename: Hermann
authors.initials: H
authors.lastname: Haller
authors.forename: Roland
authors.initials: R
authors.lastname: Schmitt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D003404:Creatinine / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D062407:Meals; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods; D013056:Spectrophotometry, Ultraviolet; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D001786:Blood Glucose; D014527:Uric Acid; D014508:Urea; D003404:Creatinine