title: New eudesmane-type sesquiterpenoid from Solanum lyratum with cytotoxic activity.
abstract: In our continuing effort to discover more new cytotoxic sesquiterpenoids from Solanum lyratum, one new eudesmane-type sesquiterpenoid (1, 3-keto-eudesm-9β,11-diol, named lyratol G), together with one known eudesmane-type sesquiterpenoid (2, 1β-hydroxy-1,2-dihydro-α-santonin), was obtained. The structure of the new sesquiterpenoid was elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D and 2D NMR ((1)H-(1)H COSY, HMQC, HMBC and ROESY). In vitro, two sesquiterpenoids were found to exhibit significant cytotoxicity against three cancer cell lines (P-388, HONE-1 and HT-29), and gave IC50 values in the range of 3.1-6.9 μM.
authors.affiliation: a School of Pharmaceutical Science, Yantai University , Yantai 264005 , P.R. China.
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Nie
authors.forename: Fang
authors.initials: F
authors.lastname: Yao
authors.forename: Xi-Dian
authors.initials: XD
authors.lastname: Yue
authors.forename: Gui-Sheng
authors.initials: GS
authors.lastname: Li
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Dai
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D007941:Leukemia P388; D015394:Molecular Structure; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032322:Solanum / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D045787:Sesquiterpenes, Eudesmane; C000591766:lyratol G
keywords: Solanaceae; Solanum lyratum; cytotoxic activity; lyratol G; sesquiterpenoid