title: Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2.
abstract: Bone morphogenesis proteins (BMPs) are multi-functional growth factors. They are expressed in retina, retinal pigment epithelium (RPE) and sclera and serve as a regulator in the growth and development of the eye. This article reviewed the chondrogenic potency of the sclera, biochemical and pathological changes of myopic scleral tissue and the differentiation of chondrogenesis by BMP-2. We proposed the hypothesis that BMP-2 can regulate differentiate of scleral fibroblasts and affect the development of myopia.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.
authors.forename: Hong-Hui
authors.initials: HH
authors.lastname: Li
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Huo
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.
authors.forename: Zhen-Ya
authors.initials: ZY
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.
authors.forename: Jun-Wen
authors.initials: JW
authors.lastname: Zeng
keywords: bone morphogenetic protein-2; myopia; sclera