title: In vivo anti-inflammatory activity of some naturally occurring O- and N-prenyl secondary metabolites.
abstract: A series of O- and N-prenyl secondary metabolites of insect, fungal, and plant origin have been evaluated for their topical anti-inflammatory activity using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds revealed an effect (ID50 = 0.31 divided by 0.56 micromol/cm2) comparable with that of the reference non-steroidal anti-inflammatory drug indomethacin (ID50 = 0.23 micromol/cm2).
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
authors.forename: Serena
authors.initials: S
authors.lastname: Fiorito
authors.forename: Roberto
authors.initials: R
authors.lastname: della Loggia
authors.forename: Aurelia
authors.initials: A
authors.lastname: Tubaro
authors.forename: Silvio
authors.initials: S
authors.lastname: Sosa
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification*; D001203:Ascomycota / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D051379:Mice; D010420:Pentanes / Q000302:isolation & purification*; D027821:Rutaceae / Q000737:chemistry* / Q000378:metabolism; D064210:Secondary Metabolism; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000302:isolation & purification; D062367:ortho-Aminobenzoates / Q000302:isolation & purification*
chemical_list: D000893:Anti-Inflammatory Agents; C587831:N-acetyl-O-isopentenyl-L-tyrosine; C587830:N-isopentenylanthranilic acid geranyl ester; D010420:Pentanes; D062367:ortho-Aminobenzoates; D014443:Tyrosine