title: Cell death paradigms in the pathogenesis of Mycobacterium tuberculosis infection.
abstract: Cell death or senescence is a fundamental event that helps maintain cellular homeostasis, shapes the growth of organism, and provides protective immunity against invading pathogens. Decreased or increased cell death is detrimental both in infectious and non-infectious diseases. Cell death is executed both by regulated enzymic reactions and non-enzymic sudden collapse. In this brief review we have tried to summarize various cell death modalities and their impact on the pathogenesis of Mycobacterium tuberculosis.
authors.affiliation: Department of Immunology, National Institute for Research in Tuberculosis Chennai, India ; Department of Immunology, International Centre for Genetic Engineering and Biotechnology New Delhi, India.
authors.forename: Dinesh Kumar
authors.initials: DK
authors.lastname: Parandhaman
authors.affiliation: Department of Immunology, National Institute for Research in Tuberculosis Chennai, India.
authors.forename: Sujatha
authors.initials: S
authors.lastname: Narayanan
mesh_terms: D000818:Animals; D016923:Cell Death; D054884:Host-Pathogen Interactions; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000502:physiology*; D014376:Tuberculosis / Q000276:immunology* / Q000473:pathology*
keywords: Mycobacterium tuberculosis; apoptosis; autophagy; extrinsic pathway; intrinsic pathway; pyroptosis