title: Fibrin glue and biliary anastomotic leak after liver transplant.
abstract: OBJECTIVE
  Fibrin sealants may prevent hemorrhage and biliary leakage after liver resection. We evaluated the effects of topical fibrin glue application on biliary anastomosis in deceased-donor liver transplant.
  
  
  METHODS
  From January 2011 to July 2013, fibrin glue was applied around the biliary anastomosis in 10 patients who had deceased-donor liver transplant (recipients: female, 8 patients; median age, 46.9 y) with end-to-end choledochocholedochostomy in 9 patients and hepaticojejunostomy in 1 patient. Biliary leakage was diagnosed with abdominal computed tomography.
  
  
  RESULTS
  Biliary leakage was observed in 1 patient at 18 days after deceased-donor liver transplant with end-to-end choledochocholedochostomy. This was treated with revision laparotomy and reconstruction of the biliary anastomotic leak with a hepaticojejunostomy and placement of an internal stent and fibrin glue; the patient 's condition improved. There were no perioperative deaths.
  
  
  CONCLUSIONS
  In deceased-donor liver transplant, application of fibrin glue at the biliary anastomosis may be associated with.
authors.affiliation: Department of Surgery, Karadeniz Technical University, School of Medicine, Farabi Hospital, Trabzon, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Topaloğlu
authors.forename: Adnan
authors.initials: A
authors.lastname: Çalık
authors.forename: Orhan
authors.initials: O
authors.lastname: Kalaycı
authors.forename: Kutay
authors.initials: K
authors.lastname: Sağlam
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yazıcı
authors.forename: Coşkun
authors.initials: C
authors.lastname: Aydın
mesh_terms: D000328:Adult; D057868:Anastomotic Leak / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control* / Q000601:surgery; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive