title: Regional adipose tissue hormone/cytokine production before and after weight loss in abdominally obese women.
abstract: OBJECTIVE
  To compare the regional differences in subcutaneous adipose tissue hormone/cytokine production in abdominally obese women during weight loss.
  
  
  METHODS
  Forty-two abdominally obese, older women underwent a 20-week weight loss intervention composed of hypocaloric diet with or without aerobic exercise (total energy expenditure: ∼2800 kcal/week). Subcutaneous (gluteal and abdominal) adipose tissue biopsies were conducted before and after the intervention. Adipose tissue gene expression and release of leptin, adiponectin, and interleukin 6 (IL-6) were determined.
  
  
  RESULTS
  The intervention resulted in significant weight loss (-10.1 ± 0.7 kg, P < 0.001). At baseline, gene expression of adiponectin were higher (P < 0.01), and gene expression and release of IL-6 were lower (both P < 0.05) in abdominal than in gluteal adipose tissue. After intervention, leptin gene expression and release were lower in both gluteal and abdominal adipose tissue compared to baseline (P < 0.05-0.01). Abdominal, but not gluteal, adipose tissue adiponectin gene expression and release increased after intervention (both P < 0.05).
  
  
  CONCLUSIONS
  A 20-week weight loss program decreased leptin production in both gluteal and abdominal adipose tissue, but only increased adiponectin production from abdominal adipose tissue in obese women. This depot-specific effect may be of importance for the treatment of health complications associated with abdominal adiposity.
authors.affiliation: Department of Exercise and Health Sciences, University of Massachusetts Boston, Boston, Massachusetts, USA.
authors.forename: Tongjian
authors.initials: T
authors.lastname: You
authors.forename: Xuewen
authors.initials: X
authors.lastname: Wang
authors.forename: Karin M
authors.initials: KM
authors.lastname: Murphy
authors.forename: Mary F
authors.initials: MF
authors.lastname: Lyles
authors.forename: Jamehl L
authors.initials: JL
authors.lastname: Demons
authors.forename: Rongze
authors.initials: R
authors.lastname: Yang
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Gong
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Nicklas
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000273:Adipose Tissue / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D016207:Cytokines / Q000378:metabolism*; D004038:Diet, Reducing; D002149:Energy Intake / Q000502:physiology; D015444:Exercise; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000503:physiopathology*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D052242:Adiponectin; D016207:Cytokines; D015850:Interleukin-6; D020738:Leptin
keywords: Abdominal Obesity; Adipose Tissue; Cytokines; Hormones; Weight Loss