title: Juvenile mycosis fungoides: cutaneous T-cell lymphoma with frequent follicular involvement.
abstract: BACKGROUND
  The literature on mycosis fungoides (MF) in children/adolescents is sparse.
  
  
  OBJECTIVE
  We sought to evaluate the characteristics of juvenile MF in a large cohort.
  
  
  METHODS
  Data were collected on all patients with MF, aged 18 years or younger at the time of clinicopathologic diagnosis, who attended the Rabin Medical Center Dermatology Department, Petach Tikva, Israel, between 1994 and 2012 and were followed up prospectively.
  
  
  RESULTS
  There were 50 patients (30 male; mean age 11.4 years at diagnosis); 18 (36%) had Fitzpatrick skin type IV or higher. All were given a diagnosis of early-stage disease (IA-IIA) except 1 (tumor stage, IIB). Eight had classic MF lesions only and 42 had other variants, alone or in combination; these were mainly hypopigmented MF (n = 29) and cases with subtle but clear clinicopathologic features of folliculotropic MF (FMF) (n = 18). Among the various skin-targeted therapies, psoralen plus ultraviolet A (systemic/bath) proved beneficial for FMF. During a follow-up period of 0.25 to 15 years (mean 4.5), 2 patients progressed from stage IA to IB or IIA.
  
  
  CONCLUSIONS
  Relatively short follow-up is a limitation.
  
  
  CONCLUSIONS
  This case series shows that FMF is not uncommon in children and adolescents. It is characterized by more superficial clinical features and less heavy perifollicular lymphocytic infiltrates than adult FMF, and responds well to psoralen plus ultraviolet A. The prognosis of childhood FMF remains unclear.
authors.affiliation: Department of Dermatology, Rabin Medical Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: hodake@post.tau.ac.il.
authors.forename: Emmilia
authors.initials: E
authors.lastname: Hodak
authors.affiliation: Department of Dermatology, Rabin Medical Center, Petach Tikva, Israel.
authors.forename: Iris
authors.initials: I
authors.lastname: Amitay-Laish
authors.affiliation: Department of Pathology, Rabin Medical Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Meora
authors.initials: M
authors.lastname: Feinmesser
authors.affiliation: Department of Dermatology, Rabin Medical Center, Petach Tikva, Israel.
authors.forename: Batya
authors.initials: B
authors.lastname: Davidovici
authors.affiliation: Department of Dermatology, Rabin Medical Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: David
authors.affiliation: Unit of Pediatric Dermatology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel; Faculty of Health Sciences, Medical School for International Health, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Alex
authors.initials: A
authors.lastname: Zvulunov
authors.affiliation: Department of Dermatology, Sheba Medical Center, Ramat Gan, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Felix
authors.initials: F
authors.lastname: Pavlotsky
authors.affiliation: Department of Pediatric Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Isaac
authors.initials: I
authors.lastname: Yaniv
authors.affiliation: Department of Pediatric Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Gali
authors.initials: G
authors.lastname: Avrahami
authors.affiliation: Unit of Pediatric Dermatology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Dan
authors.initials: D
authors.lastname: Ben-Amitai
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D007557:Israel; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D009182:Mycosis Fungoides / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000532:radiotherapy; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D012878:Skin Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000532:radiotherapy; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000379:methods
keywords: children; cutaneous lymphoma; folliculotropic mycosis fungoides; juvenile; mycosis fungoides; pediatric