title: Route to hemocompatible polyethersulfone membranes via surface aminolysis and heparinization.
abstract: Polyethersulfone (PES) membranes with improved hemocompatibility were prepared via solid-liquid interface aminolysis and heparinization. Reactive amino groups were generated by immersing solid PES membranes in proper diamine solution. Heparin was covalent immobilized on the surface via amide bond. The feasibility of surface aminolysis for the introduction of amino groups and the effectiveness for further heparin immobilization were confirmed by surface group analysis. The effect of aminolysis time on surface amino group concentration and bulk mechanical properties was investigated. The surface amino group concentration determined the amount and bioactivity of immobilized heparin chains. SEM images suggested that both the aminolysis and heparinization reaction had little effect on the surface morphology of PES membranes. Contact angle measurement, surface charge analysis, protein and platelet adsorption/adhesion experiment were applied to study the surface properties. The results showed that the heparinized PES membranes displayed enhanced hydrophilicity and hemocompatibility, indicating potential application in blood purification and other blood contacting fields.
authors.affiliation: Key Laboratory of Macromolecule Synthesis and Functionalization (MOE), ERC of Membrane and Water Treatment (MOE), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Linghui
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory of Macromolecule Synthesis and Functionalization (MOE), ERC of Membrane and Water Treatment (MOE), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Key Laboratory of Macromolecule Synthesis and Functionalization (MOE), ERC of Membrane and Water Treatment (MOE), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Yihang
authors.initials: Y
authors.lastname: Jing
authors.affiliation: Key Laboratory of Macromolecule Synthesis and Functionalization (MOE), ERC of Membrane and Water Treatment (MOE), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: zhubk@zju.edu.cn.
authors.forename: Baoku
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Macromolecule Synthesis and Functionalization (MOE), ERC of Membrane and Water Treatment (MOE), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Macromolecule Synthesis and Functionalization (MOE), ERC of Membrane and Water Treatment (MOE), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Youyi
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000588:Amines / Q000737:chemistry*; D001672:Biocompatible Materials; D001769:Blood; D006493:Heparin / Q000737:chemistry*; D008567:Membranes, Artificial; D011108:Polymers / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000588:Amines; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C022840:polyether sulfone; D006493:Heparin
keywords: Aminolysis; Hemocompatibility; Heparin immobilization; Polyethersulfone membrane; Surface modification