title: Campylobacter fetus infections.
abstract: BACKGROUND
  Campylobacter fetus infections usually occur in immunodepressed patients or patients presenting with diabetes mellitus or cancer. They rarely cause diarrhea but frequently cause bacteremia or vascular diseases. The therapeutic management is not well codified and fluoroquinolone resistance is continuously increasing.
  
  
  METHODS
  We conducted a retrospective study of C. fetus infections from January 2007 to August 2013 at the Limoges teaching hospital. The infections were defined by at least 1 bacteriological sample positive for C. fetus.
  
  
  RESULTS
  Twenty patients were included (15 men), with an average age of 73 years (43-91). Sixteen presented with cancer, 12 with solid cancer including 9 of the urinary tract, and 9 patients with hematologic diseases. Five patients presented with diabetes mellitus, 9 with isolated bacteremia, 3 with cellulitis, and 3 with septic arthritis. The diagnosis was made by blood cultures for 17 patients. Twenty percent of the isolates were resistant to amoxicillin and 30% to fluoroquinolones. The therapeutic regimens and the treatment duration were quite different. The outcome was unfavorable for 3 patients whose implanted port had not been removed and 1 with subdural hematoma infection. 1 patient died.
  
  
  CONCLUSIONS
  C. fetus infection occurs in case of underlying diseases, most frequently promoting urinary tract cancer. Fluoroquinolones must not be used without susceptibility testing and catheters should be removed.
authors.affiliation: Service de maladies infectieuses et tropicales, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France. Electronic address: anne.cypierre@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Cypierre
authors.affiliation: Service de maladies infectieuses et tropicales, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France. Electronic address: e.denes@free.fr.
authors.forename: E
authors.initials: E
authors.lastname: Denes
authors.affiliation: Service de bactériologie, virologie, hygiène, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France. Electronic address: olivier.barraud@unilim.fr.
authors.forename: O
authors.initials: O
authors.lastname: Barraud
authors.affiliation: Service de maladies infectieuses et tropicales, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France. Electronic address: yvanjamilloux@hotmail.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Jamilloux
authors.affiliation: Service d'hépato-gastro-entérologie, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France. Electronic address: jeremie.jacques@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Jacques
authors.affiliation: Service de maladies infectieuses et tropicales, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France. Electronic address: helene.durox@chu-limoges.fr.
authors.forename: H
authors.initials: H
authors.lastname: Durox
authors.affiliation: Service de maladies infectieuses et tropicales, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France. Electronic address: pauline.pinet@chu-limoges.fr.
authors.forename: P
authors.initials: P
authors.lastname: Pinet
authors.affiliation: Service de maladies infectieuses et tropicales, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France. Electronic address: pierre.weinbreck@unilim.fr.
authors.forename: P
authors.initials: P
authors.lastname: Weinbreck
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D002169:Campylobacter Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D002168:Campylobacter fetus; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents
keywords: Campylobacter fetus; Cancer; Catheter; Cathéter; Diabetes mellitus; Diabète