title: Effects of antibacterial nanostructured composite films on vascular stents: hemodynamic behaviors, microstructural characteristics, and biomechanical properties.
abstract: The purpose of this research was to investigate stresses resulting from different thicknesses and compositions of hydrogenated Cu-incorporated diamond-like carbon (a-C:H/Cu) films at the interface between vascular stent and the artery using three-dimensional reversed finite element models (FEMs). Blood flow velocity variation in vessels with plaques was examined by angiography, and the a-C:H/Cu films were characterized by transmission electron microscopy to analyze surface morphology. FEMs were constructed using a computer-aided reverse design system, and the effects of antibacterial nanostructured composite films in the stress field were investigated. The maximum stress in the vascular stent occurred at the intersections of net-like structures. Data analysis indicated that the stress decreased by 15% in vascular stents with antibacterial nanostructured composite films compared to the control group, and the stress decreased with increasing film thickness. The present results confirmed that antibacterial nanostructured composite films improve the biomechanical properties of vascular stents and release abnormal stress to prevent restenosis. The results of the present study offer the clinical benefit of inducing superior biomechanical behavior in vascular stents.
authors.affiliation: Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei 110, Taiwan; Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Han-Yi
authors.initials: HY
authors.lastname: Cheng
authors.forename: Wen-Tien
authors.initials: WT
authors.lastname: Hsiao
authors.forename: Li-Hsiang
authors.initials: LH
authors.lastname: Lin
authors.forename: Ya-Ju
authors.initials: YJ
authors.lastname: Hsu
authors.forename: Andi Wardihan
authors.initials: AW
authors.lastname: Sinrang
authors.forename: Keng-Liang
authors.initials: KL
authors.lastname: Ou
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001696:Biomechanical Phenomena; D020342:Finite Element Analysis; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D015607:Stents
chemical_list: D000900:Anti-Bacterial Agents
keywords: 3D-reversed model; biomechanics; finite element analysis; surface treatment; vascular stent