title: Development of solid-supported Glaser-Hay couplings.
abstract: While the Glaser-Hay coupling of terminal alkynes is a useful reaction, several issues associated with chemoselectivity preclude its widespread application in synthetic chemistry. To address these issues, a solid-supported Glaser-Hay methodology was developed to afford only asymmetric diyne products. This methodology was then applied to a series of immobilized alkynes with a diverse set of soluble alkynes to generate an array of heterocoupled products in high yields and purities.
authors.affiliation: Department of Chemistry, College of William & Mary , P.O. Box 8795, Williamsburg, Virginia 23187, United States.
authors.forename: Valerie T
authors.initials: VT
authors.lastname: Tripp
authors.forename: Jessica S
authors.initials: JS
authors.lastname: Lampkowski
authors.forename: Ryan
authors.initials: R
authors.lastname: Tyler
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Young
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D003300:Copper