title: Two Pb2+-specific DNAzymes with opposite trends in split-site-dependent activity.
abstract: By splitting the catalytic core of DNAzymes into two halves, two Pb(2+)-specific DNAzymes retain partial activity, while they show opposite trends of activity as a function of the split site, revealing important nucleotides for catalysis and metal binding.
authors.affiliation: Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. liujw@uwaterloo.ca.
authors.forename: Po-Jung Jimmy
authors.initials: PJ
authors.lastname: Huang
authors.forename: Juewen
authors.initials: J
authors.lastname: Liu
mesh_terms: D001483:Base Sequence; D002384:Catalysis; D020134:Catalytic Domain; D021881:DNA, Catalytic / Q000378:metabolism*; D007477:Ions / Q000737:chemistry; D007854:Lead / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009711:Nucleotides / Q000737:chemistry
chemical_list: D021881:DNA, Catalytic; D007477:Ions; D009711:Nucleotides; D007854:Lead