title: Effect of eccentric versus concentric exercise training on mitochondrial function.
abstract: BACKGROUND
  The effect of eccentric (ECC) versus concentric (CON) training on metabolic properties in skeletal muscle is understood poorly. We determined the responses in oxidative capacity and mitochondrial H2 O2 production after eccentric (ECC) versus concentric (CON) training performed at similar mechanical power.
  
  
  METHODS
  Forty-eight rats performed 5- or 20-day eccentric (ECC) or concentric (CON) training programs. Mitochondrial respiration, H2 O2 production, citrate synthase activity (CS), and skeletal muscle damage were assessed in gastrocnemius (GAS), soleus (SOL) and vastus intermedius (VI) muscles.
  
  
  RESULTS
  Maximal mitochondrial respiration improved only after 20 days of concentric (CON) training in GAS and SOL. H2 O2 production increased specifically after 20 days of eccentric ECC training in VI. Skeletal muscle damage occurred transiently in VI after 5 days of ECC training.
  
  
  CONCLUSIONS
  Twenty days of ECC versus CON training performed at similar mechanical power output do not increase skeletal muscle oxidative capacities, but it elevates mitochondrial H2 O2 production in VI, presumably linked to transient muscle damage.
authors.affiliation: Strasbourg University, Physical and Rehabilitation Medicine Department, Strasbourg University Rehabilitation Institute, France; Strasbourg University, Fédération de Médecine Translationnelle de Strasbourg (FMTS), EA 3072 "Mitochondrie, stress oxydant et protection musculaire", France.
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Isner-Horobeti
authors.forename: Laurence
authors.initials: L
authors.lastname: Rasseneur
authors.forename: Evelyne
authors.initials: E
authors.lastname: Lonsdorfer-Wolf
authors.forename: Stéphane Pascal
authors.initials: SP
authors.lastname: Dufour
authors.forename: Stéphane
authors.initials: S
authors.lastname: Doutreleau
authors.forename: Jamal
authors.initials: J
authors.lastname: Bouitbir
authors.forename: Joffrey
authors.initials: J
authors.lastname: Zoll
authors.forename: Sophia
authors.initials: S
authors.lastname: Kapchinsky
authors.forename: Bernard
authors.initials: B
authors.lastname: Geny
authors.forename: Frédéric Nicolas
authors.initials: FN
authors.lastname: Daussin
authors.forename: Yan
authors.initials: Y
authors.lastname: Burelle
authors.forename: Ruddy
authors.initials: R
authors.lastname: Richard
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D015992:Body Mass Index; D002950:Citrate (si)-Synthase / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008451:Maximal Voluntary Ventilation; D008931:Mitochondria, Muscle / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000648:ultrastructure*; D018384:Oxidative Stress / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D019802:Succinic Acid; D013997:Time Factors
chemical_list: D019344:Lactic Acid; D000244:Adenosine Diphosphate; D019802:Succinic Acid; D006861:Hydrogen Peroxide; D002950:Citrate (si)-Synthase; D003402:Creatine Kinase
keywords: eccentric exercise; mitochondria; oxidative capacities; reactive oxygen species; skeletal muscle