title: Sleep-disordered breathing in patients with heart failure.
abstract: Sleep-disordered breathing (SDB) is prevalent in patients with heart failure, and is associated with increased morbidity and mortality. SDB is proinflammatory, with nocturnal oxygen desaturations and hypercapnia appearing to play a pivotal role in the development of oxidative stress and sympathetic activation. Preliminary data suggest that attention to the diagnosis and management of SDB in patients with heart failure may improve outcomes. Ongoing research into the roles of comorbidities such as SDB as a treatment target may lead to better clinical outcomes and improved quality of life for patients with heart failure.
authors.affiliation: Duke University Medical Center, Duke Clinical Research Institute, 2301 Erwin Road, Durham, NC 27710, USA. Electronic address: robert.mentz@duke.edu.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Mentz
authors.affiliation: Duke University Medical Center, Duke Clinical Research Institute, 2301 Erwin Road, Durham, NC 27710, USA.
authors.forename: Mona
authors.initials: M
authors.lastname: Fiuzat
mesh_terms: D006333:Heart Failure / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy
keywords: Adaptive servoventilation; Clinical trials; Comorbidities; Heart failure; Outcomes; Positive airway pressure; Sleep apnea