title: Capture and release of cancer cells based on sacrificeable transparent MnO2 nanospheres thin film.
abstract: A CTCs detection assay using transparent MnO2 nanospheres thin films to capture and release of CTCs is reported. The enhanced local topography interaction between extracellular matrix scaffolds and the antibody-coated substrate leads to improved capture efficiency. CTCs captured from artificial blood sample can be cultured and released, represent a new functional material capable of CTCs isolation and culture for subsequent studies.
authors.affiliation: Key Laboratory of Artificial Micro- and Nanostructures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, 430072, Hubei, P. R. China.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Huang
authors.forename: Bolei
authors.initials: B
authors.lastname: Chen
authors.forename: Rongxiang
authors.initials: R
authors.lastname: He
authors.forename: Zhaobo
authors.initials: Z
authors.lastname: He
authors.forename: Bo
authors.initials: B
authors.lastname: Cai
authors.forename: Junhua
authors.initials: J
authors.lastname: Xu
authors.forename: Weiyi
authors.initials: W
authors.lastname: Qian
authors.forename: Helen Laiwa
authors.initials: HL
authors.lastname: Chan
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Shishang
authors.initials: S
authors.lastname: Guo
authors.forename: Xing-Zhong
authors.initials: XZ
authors.lastname: Zhao
authors.forename: Jikang
authors.initials: J
authors.lastname: Yuan
mesh_terms: D000906:Antibodies / Q000737:chemistry / Q000378:metabolism; D000951:Antigens, Neoplasm / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D045744:Cell Line, Tumor; D002469:Cell Separation / Q000295:instrumentation*; D002470:Cell Survival; D000071858:Epithelial Cell Adhesion Molecule; D006801:Humans; D017895:Manganese Compounds / Q000737:chemistry*; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D049329:Nanostructures; D009360:Neoplastic Cells, Circulating / Q000737:chemistry / Q000378:metabolism*; D019815:Oxalic Acid; D010087:Oxides / Q000737:chemistry*
chemical_list: D000906:Antibodies; D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D000071858:Epithelial Cell Adhesion Molecule; D017895:Manganese Compounds; D010087:Oxides; D019815:Oxalic Acid; C016552:manganese dioxide
keywords: MnO2 nanospheres; cell release; circulating tumor cells; transparent