title: [Case report of pulmonary biphasic tumor with unusual follow-up].
abstract: BACKGROUND
  Pulmonary blastoma, a rare primary lung malignancy is subdivided in 3 categories: well-differentiated fetal adenocarcinoma (WDFA), classic biphasic pulmonary blastoma (CBPB) and pleuropulmonary blastoma (PPB). Classic pulmonary blastoma is composed of a mixture of immature epithelial and mesenchymal tissue resembling fetal lung tissue.
  
  
  METHODS
  We described a case of a 48-year-old male, cigarette smoker, who presented with left thoracic pain and hemoptysis for 2 months. Chest radiography showed a well-delimited, homogeneous 4cm mass in the left lung periphery. Bronchoscopic examination revealed left endobronchial bleeding. Computed tomography of the chest revealed a tumor shadow measuring 7cm in the left upper lobe and bilateral nodules with no lymphadenopathy. A systemic evaluation demonstrated no metastatic lesion. Patient underwent a left upper lobectomy. The diagnosis of CBPB was affirmed on anatomopathology of the tumor resection. Immunohistochemical studies showed that tumor cells were positive for vimentin, desmin, actin, Pan Cytokeratin and TTF-1. The final diagnosis was BPB classified as pathological T3N0M0 and no adjuvant treatment was associated. The patient showed good objective response with no evidence of disease recurrence still in 5 years surgery resection.
  
  
  CONCLUSIONS
  This case reiterates the importance of pathomorphological or immunohistochemical features in diagnosis of BPB.
authors.affiliation: Service de pneumologie pavillon C, hôpital Abderrahmen Mami, Ariana 2080, Tunisie. Electronic address: hafaoua.daghfous@yahoo.fr.
authors.forename: H
authors.initials: H
authors.lastname: Daghfous
authors.affiliation: Service de pneumologie pavillon C, hôpital Abderrahmen Mami, Ariana 2080, Tunisie. Electronic address: nidhalbelloumi@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Belloumi
authors.affiliation: Service d'anatomopathologie, hôpital Abderrahmen Mami, Ariana 2080, Tunisie. Electronic address: emnabraham@yahoo.fr.
authors.forename: E
authors.initials: E
authors.lastname: Braham
authors.affiliation: Service de pneumologie pavillon C, hôpital Abderrahmen Mami, Ariana 2080, Tunisie. Electronic address: soumayaalabizertine@yahoo.fr.
authors.forename: S
authors.initials: S
authors.lastname: Ben Saad
authors.affiliation: Service de pneumologie pavillon C, hôpital Abderrahmen Mami, Ariana 2080, Tunisie. Electronic address: bey_rihab@yahoo.fr.
authors.forename: R
authors.initials: R
authors.lastname: El Bay
authors.affiliation: Service d'anatomopathologie, hôpital Abderrahmen Mami, Ariana 2080, Tunisie. Electronic address: faouzi.elmezni@rns.tn.
authors.forename: F
authors.initials: F
authors.lastname: El Mezni
authors.affiliation: Service de pneumologie pavillon C, hôpital Abderrahmen Mami, Ariana 2080, Tunisie. Electronic address: fatma.tritar@rns.tn.
authors.forename: F
authors.initials: F
authors.lastname: Tritar
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001999:Bronchoscopy; D049109:Cell Proliferation / Q000502:physiology; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008197:Lymph Node Excision; D008297:Male; D059630:Mesenchymal Stem Cells / Q000473:pathology; D008875:Middle Aged; D009336:Necrosis; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011013:Pneumonectomy; D018202:Pulmonary Blastoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor
keywords: Blastome pulmonaire; Cancer du poumon; Chirurgie; Hemoptysis; Hémoptysie; Immuno-histochimie; Immunohistochemical study; Lung cancer; Prognosis; Pronostic; Pulmonary blastoma; Surgery