title: [Immunogenetic features of apoptosis in workers engaged in methanol production].
abstract: Disordered cellular death process with inhibition is seen during stress states including occupational activities associated with increased concentrations of methanol in biologic media. Workers exposed to methanol demonstrate prevalence of homozygous type of tumor necrosis factor (TNF) gene and heterozygous variant of cytochrome 450 gene, reliably increased vs reference group. Genetic changes in the main group are associated with reliable decrease in occurrence of transcription protein p53 and TNF receptor, and with altered ratio of intracellular apoptosis factors (bax and bcl-2) towards slower programmed cellular death in chemical production.
authors.forename: O V
authors.initials: OV
authors.lastname: Dolgikh
authors.forename: A V
authors.initials: AV
authors.lastname: Krivtsov
authors.forename: O A
authors.initials: OA
authors.lastname: Bubnova
authors.forename: R A
authors.initials: RA
authors.lastname: Predeina
authors.forename: D G
authors.initials: DG
authors.lastname: Dianova
authors.forename: O O
authors.initials: OO
authors.lastname: Sinitsyna
authors.forename: N N
authors.initials: NN
authors.lastname: Maliutina
authors.forename: L A
authors.initials: LA
authors.lastname: Taranenko
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000235:genetics / Q000276:immunology*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics; D002617:Chemical Industry; D003580:Cytochromes / Q000235:genetics; D006801:Humans; D055261:Immunogenetic Phenomena / Q000235:genetics / Q000276:immunology*; D000432:Methanol / Q000633:toxicity*; D009784:Occupational Diseases / Q000139:chemically induced / Q000235:genetics / Q000276:immunology*; D010446:Peptide Fragments / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D000078329:Workforce
chemical_list: D051017:Apoptosis Regulatory Proteins; D003580:Cytochromes; D010446:Peptide Fragments; D014409:Tumor Necrosis Factor-alpha; D016159:Tumor Suppressor Protein p53; C509415:p53 protein (325-355), human; D000432:Methanol