title: Therapeutic opportunities for medulloblastoma come of age.
abstract: In this issue of Cancer Cell, Kool and colleagues reveal clear genetically defined subclasses of the sonic hedgehog (SHH) subclass of medulloblastoma. This molecular dissection of the SHH subclass is not simply a cutting-edge advance; the data have profound impact on clinical trial design and decision-making.
authors.affiliation: Fred Hutchinson Cancer Research Center and Seattle Children's Hospital, Seattle WA 98109, USA. Electronic address: jolson@fhcrc.org.
authors.forename: James M
authors.initials: JM
authors.lastname: Olson
mesh_terms: D000818:Animals; D060965:Clonal Evolution / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*