title: Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder.
abstract: OBJECTIVE
  To explore the relationship between regional cerebral blood flow (CBF) and cognitive function in obsessive-compulsive disorder (OCD).
  
  
  METHODS
  Single-photon emission computed tomography (SPECT) was performed for 139 OCD patients and 139 controls, and the radioactivity rate (RAR) was calculated. Cognitive function was assessed by the Wisconsin Card Sorting Test (WCST).
  
  
  RESULTS
  The RARs of the prefrontal, anterior temporal, and right occipital lobes were higher in patients than controls. For the WCST, correct and classification numbers were significantly lower, and errors and persistent errors were significantly higher in OCD patients. Right prefrontal lobe RAR was negatively correlated with correct numbers, right anterior temporal lobe RAR was positively correlated with errors, and the RARs of the right prefrontal lobe and left thalamus were positively correlated with persistent errors.
  
  
  CONCLUSIONS
  OCD patients showed higher CBF in the prefrontal and anterior temporal lobes, suggesting that these areas may be related with cognitive impairment.
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Huirong
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Neurology, Henan Provincial People's Hospital.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhao
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Binhua
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: He
authors.initials: H
authors.lastname: Cui
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Youhui
authors.initials: Y
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000098:blood supply*; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology*; D015899:Tomography, Emission-Computed, Single-Photon; D055815:Young Adult