title: Isoxazoline containing natural products as anticancer agents: a review.
abstract: Isoxazolines are an important class of nitrogen and oxygen containing heterocycles that belong to the azoles family which have gained much importance in the field of medicinal chemistry as the anticancer agents. Moreover, natural products are always expectedly regarded as an important hoard of a large number of potential chemotherapeutic candidates. Therefore, this review mainly focuses on the existence of isoxazoline derivatives in natural sources, their isolation and uses there of as anticancer agents besides highlighting the synthetic pathways to achieve these compounds. Structural-activity relationship and the influence of stereochemical aspects on anticancer activity of such compounds have also been discussed. It covers the literature upto 2014 and would certainly provide a great insight to scientific community to accelerate further research for the development of some novel anticancer drugs.
authors.affiliation: Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala 133207, India.
authors.forename: Kamalneet
authors.initials: K
authors.lastname: Kaur
authors.affiliation: Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala 133207, India. Electronic address: vinodbatan@gmail.com.
authors.forename: Vinod
authors.initials: V
authors.lastname: Kumar
authors.affiliation: Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala 133207, India.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Sharma
authors.affiliation: Department of Pharmaceutical Chemistry, Maharishi Markandeshwar University, Mullana, Ambala 133207, India.
authors.forename: Girish Kumar
authors.initials: GK
authors.lastname: Gupta
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007555:Isoxazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D007555:Isoxazoles
keywords: Anticancer; Cytotoxic; Isoxazolines; Natural products; Stereochemistry