title: Elevated plasma levels of soluble (pro)renin receptor in patients with obstructive sleep apnea syndrome: association with polysomnographic parameters.
abstract: (Pro)renin receptor ((P)RR) is a specific receptor for both renin and its precursor prorenin. (P)RR was shown to be involved in pathophysiology of cardiovascular and renal diseases. Soluble (pro)renin receptor (s(P)RR), which is generated by furin from full length (P)RR, is present in blood. The aim of the present study is to clarify the association of plasma s(P)RR levels and the severity of OSAS. Plasma levels of s(P)RR were measured by ELISA in 58 male patients diagnosed as OSAS based on polysomnography, and 14 age-matched male control subjects. Blood samples were obtained at 6:00 a.m. just after overnight polysomnography. Plasma s(P)RR levels were significantly higher in patients with OSAS (9.0±2.0 ng/mL, mean ± SD) than in control subjects (7.4±1.5 ng/mL) (P=0.0026). Plasma s(P)RR levels showed a significant negative correlation with % stage rapid eye movement (REM) sleep (r=-0.377, p<0.005), and significant positive correlations with % stage 1 (r=0.374, p<0.005), arousal index (r=0.341, p<0.01), apnea hypopnea index (AHI) (r=0.352, p<0.01) and desaturation index (r=0.302, p<0. 05). In 12 OSAS patients with AHI ≥20, plasma levels of s(P)RR were studied after 3-month treatment with nasal continuous positive airway pressure (nCPAP). Plasma s(P)RR levels were significantly decreased after the nCPAP treatment (p=0.0016). The present study has shown for the first time elevated plasma s(P)RR levels in patients with OSAS. Plasma s(P)RR levels were associated with the severity of OSAS. Soluble (P)RR may serve as a plasma marker reflecting the severity of OSAS.
authors.affiliation: Division of Behavioral Sleep Medicine, Iwate Medical University School of Medicine, Morioka, Iwate 020-8505, Japan.
authors.forename: Tsuguo
authors.initials: T
authors.lastname: Nishijima
authors.affiliation: Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Tajima
authors.affiliation: Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Division of Behavioral Sleep Medicine, Iwate Medical University School of Medicine, Morioka, Iwate 020-8505, Japan. Electronic address: ssakurai@iwate-med.ac.jp.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sakurai
mesh_terms: D000328:Adult; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011956:Receptors, Cell Surface / Q000097:blood*; D012083:Renin; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy; D025262:Vacuolar Proton-Translocating ATPases / Q000097:blood*; D000093342:Prorenin Receptor
chemical_list: D011956:Receptors, Cell Surface; D012083:Renin; D025262:Vacuolar Proton-Translocating ATPases; C458319:ATP6AP2 protein, human; D000093342:Prorenin Receptor
keywords: Aldosterone; Apnea hypopnea index; Obstructive sleep apnea syndrome; Prorenin; Renin; Soluble (pro)renin receptor