title: Desegmentation of Ozurdex implant in vitreous cavity: report of two cases.
abstract: OBJECTIVE
  To report two cases of desegmentation or fracture of the Ozurdex implant observed immediately after routine intravitreal implantation for macular oedema.
  
  
  METHODS
  In two patients receiving intravitreal Ozurdex implant injection, a rare complication of fracture of implant was noted immediately after the injection. No additional complication was noted in either of the patients. On follow-up, the macular oedema had resolved and there were no further complications.
  
  
  CONCLUSIONS
  We shared our experience with the manufacturer, and it was confirmed that, during the normal degradation process, the implant may become soft and break into pieces. Allergan shared their unpublished data on in vivo and in vitro drug release profile of one piece versus three pieces of implant, which is presented in this case report.
  
  
  CONCLUSIONS
  With more and more microsurgical implantation procedures, clinicians should be well aware of these unusual although rare complications. Even though the desegmented implants do not appear to cause more intraocular complications compared with single-piece implants, patients with defragmented implants should be followed up carefully to monitor for unexpected complications.
authors.affiliation: Medical Retina Service, Moorfields Eye Hospital, London, UK.
authors.forename: Rupesh
authors.identifier: http://orcid.org/0000-0002-6662-5850
authors.initials: R
authors.lastname: Agrawal
authors.affiliation: Medical Retina Service, Moorfields Eye Hospital, London, UK.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Fernandez-Sanz
authors.affiliation: Medical Retina Service, Moorfields Eye Hospital, London, UK.
authors.forename: Susmita
authors.initials: S
authors.lastname: Bala
authors.affiliation: Medical Retina Service, Moorfields Eye Hospital, London, UK.
authors.forename: Peter K F
authors.initials: PK
authors.lastname: Addison
mesh_terms: D000368:Aged; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D004868:Equipment Failure; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D012170:Retinal Vein Occlusion / Q000175:diagnosis / Q000188:drug therapy; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D014822:Vitreous Body / Q000187:drug effects*
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone
keywords: Drugs; Retina; Treatment Medical