title: Synthesis of new 1,2,3-triazol-4-yl-quinazoline nucleoside and acyclonucleoside analogues.
abstract: In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.
authors.affiliation: Laboratory of Bioorganic and Macromolecular Chemistry, Department of Chemistry, Faculty of Sciences and Technology Gueliz (FSTG), BP 549, Marrakech 40000, Morocco.
authors.forename: Abdelaaziz
authors.initials: A
authors.lastname: Ouahrouch
authors.affiliation: Laboratory of Bioorganic and Macromolecular Chemistry, Department of Chemistry, Faculty of Sciences and Technology Gueliz (FSTG), BP 549, Marrakech 40000, Morocco. taourirte@gmail.com.
authors.forename: Moha
authors.initials: M
authors.lastname: Taourirte
authors.affiliation: Institute for Organic Chemistry and Chemical Biology, Goethe-University Frankfurt am Main, Max-von-Laue-Strasse 7, D-60438 Frankfurt am Main, Germany. joachim.engels@chemie.uni-frankfurt.de.
authors.forename: Joachim W
authors.initials: JW
authors.lastname: Engels
authors.affiliation: Viral Hepatitis Laboratory Pasteur Institute Morocco, 1, Place Louis Pasteur, 20360, Casablanca 20001, Morocco.
authors.forename: Soumaya
authors.initials: S
authors.lastname: Benjelloun
authors.affiliation: Laboratory of Biomolecular and Medicinal Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, Marrakech 40000, Morocco. hblazrek50@gmail.com.
authors.forename: Hassan B
authors.initials: HB
authors.lastname: Lazrek
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic; D061565:Cycloaddition Reaction; D016174:Hepacivirus / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011799:Quinazolines / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D011799:Quinazolines; D014230:Triazoles