title: From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease.
abstract: Since its discovery in 1978 and cloning in 1984, transforming growth factor-alpha (TGF-α, TGFA) has been one of the most extensively studied EGF receptor (EGFR) ligands. In this review, we provide a historical perspective on TGFA-related studies, highlighting what we consider important advances related to its function in normal and disease states.
authors.affiliation: Departments of Medicine and Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: bhuminder.singh@vanderbilt.edu.
authors.forename: Bhuminder
authors.initials: B
authors.lastname: Singh
authors.affiliation: Departments of Medicine and Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Veteran Affairs Medical Center, Nashville, TN 37232, USA. Electronic address: robert.coffey@vanderbilt.edu.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Coffey
mesh_terms: D000818:Animals; D066255:EGF Family of Proteins / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D006197:Hair / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D016211:Transforming Growth Factor alpha / Q000235:genetics / Q000378:metabolism*
chemical_list: D066255:EGF Family of Proteins; D016211:Transforming Growth Factor alpha; D004815:Epidermal Growth Factor
keywords: Autocrine singaling; Basolateral trafficking; EGFR, epidermal growth factor receptor; Ménétrier's disease; Polarized epithelial cells; TGFA, transforming growth factor alpha