title: Clinical and hemodynamic study of tilting disc heart valve: Single-center study.
abstract: BACKGROUND
  The TTK Chitra heart valve has been developed and widely used in India. This study aimed to evaluate its hemodynamics, complications, and event-free survival in comparison with other commonly used prosthetic valves. The role of color Doppler echocardiography in the follow-up of patients with prosthetic valves was also studied.
  
  
  METHODS
  Two hundred patients underwent 249 valve replacements (122 mitral, 29 aortic, 49 both). Total follow-up was 451 patient-years.
  
  
  RESULTS
  There were 18 late deaths (3.98% ± 0.92% per patient-year). One mitral valve replacement patient (0.36% ± 0.36% per patient-year) developed valve thrombosis. Two aortic valve replacement patients (2.74% ± 1.91% per patient-year), 2 double-valve replacement patients (1.95% ± 1.36% per patient-year) and 3 mitral valve replacement patients (1.08% ± 0.62% per patient-year) developed embolic complications. Freedom from all valve related mortality and morbidity at 4 years was 86% ± 4% for mitral valve replacement, 56% ± 10% for double-valve replacement, and 89% ± 6% for aortic valve replacement. The average peak gradient, mean gradient, and average peak velocity for the aortic and mitral positions were found to be comparable to those of other commonly used valves.
  
  
  CONCLUSIONS
  The performance of this valve in terms of hemodynamic complications, mortality, and morbidity is comparable to other valves in common use. Hemodynamic gradients are more reproducible than effective orifice area, hence more beneficial for follow-up.
authors.affiliation: Gandhi Medical College, Bhopal, Madhya Pradesh, India amgitmalhotra2001@rediffmail.com.
authors.forename: Amber
authors.initials: A
authors.lastname: Malhotra
authors.affiliation: Gandhi Medical College, Bhopal, Madhya Pradesh, India.
authors.forename: Sanjay R
authors.initials: SR
authors.lastname: Pawar
authors.affiliation: Gandhi Medical College, Bhopal, Madhya Pradesh, India.
authors.forename: Anubhav
authors.initials: A
authors.lastname: Srivastava
authors.affiliation: Gandhi Medical College, Bhopal, Madhya Pradesh, India.
authors.forename: Balbir Singh
authors.initials: BS
authors.lastname: Yadav
authors.affiliation: Gandhi Medical College, Bhopal, Madhya Pradesh, India.
authors.forename: Ramprasad
authors.initials: R
authors.lastname: Kaushal
authors.affiliation: Gandhi Medical College, Bhopal, Madhya Pradesh, India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Sharma
authors.affiliation: Gandhi Medical College, Bhopal, Madhya Pradesh, India.
authors.forename: Moolchand
authors.initials: M
authors.lastname: Songra
mesh_terms: D000293:Adolescent; D000328:Adult; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D020878:Device Removal; D018572:Disease-Free Survival; D018618:Echocardiography, Doppler, Color; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D006439:Hemodynamics; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D011446:Prospective Studies; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012086:Reoperation; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: Aortic valve; Chitra; Doppler; Echocardiography; Heart valve prosthesis; Mitral valve