title: Photodynamic effect of functionalized single-walled carbon nanotubes: a potential sensitizer for photodynamic therapy.
abstract: Single-walled carbon nanotubes (SWNTs) possess unique physical and chemical properties, which make them very attractive for a wide range of applications. In particular, SWNTs and their composites have shown a great potential for photodynamic therapy (PDT). SWNTs have usually been used for photothermal therapy; herein, the photodynamic effect of two functionalized SWNTs are detected under visible light illumination in vitro and in vivo. The results indicated that the photodynamic effect is not entirely dependent on illumination time, but also on the modification method of the SWNTs. The ability of SWNTs complexes to combine with photodynamic therapy significantly improved the therapeutic efficacy of cancer treatment, and the combined treatment demonstrated a synergistic effect. These findings suggest that the SWNTs composite has great potential as sensitizer for PDT.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, P.R. China. zhangzz08@126.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Jinjin
authors.initials: J
authors.lastname: Shi
authors.forename: Ruiyuan
authors.initials: R
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Yu
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Zhang
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004249:DNA Damage / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D007097:Imines / Q000737:chemistry; D008027:Light; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008856:Microscopy, Fluorescence; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000633:toxicity; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D011095:Polyethylenes / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D007097:Imines; D037742:Nanotubes, Carbon; D017319:Photosensitizing Agents; D011095:Polyethylenes; D017382:Reactive Oxygen Species; C505405:poly(ethylene imine); D004247:DNA; D005978:Glutathione