title: Magnesium complexes as highly effective catalysts for conjugate cyanation of α,β-unsaturated amides and ketones.
abstract: Asymmetric cyanation of trimethylsilyl cyanide (TMSCN) with α,β-unsaturated amides and ketones, respectively, catalyzed by bifunctional mononuclear 1,1'-bi-2-naphthol (BINOL)-Mg and binuclear bis(prophenol)-Mg catalysts was realized. A series of synthetically important 1,4-cyano products were obtained with good to high enantioselectivities (up to 97 % ee).
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science and Institute of Biochemistry and Molecular Biology School of Life Science, Lanzhou University, Lanzhou, 730000 (P. R. China).
authors.forename: Jinlong
authors.initials: J
authors.lastname: Zhang
authors.forename: Xihong
authors.initials: X
authors.lastname: Liu
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D003486:Cyanides / Q000138:chemical synthesis / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D009284:Naphthols / Q000737:chemistry; D014297:Trimethylsilyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000577:Amides; D056831:Coordination Complexes; D003486:Cyanides; D007659:Ketones; D009284:Naphthols; D014297:Trimethylsilyl Compounds; C412332:1,1'-bi-2-naphthol; C058010:trimethylsilyl cyanide; D008274:Magnesium
keywords: asymmetric catalysis; cyanation; magnesium; synthetic methods; unsaturated ketones