title: Soft tissue wound healing at teeth, dental implants and the edentulous ridge when using barrier membranes, growth and differentiation factors and soft tissue substitutes.
abstract: OBJECTIVE
  To review the biological processes of wound healing following periodontal and periimplant plastic surgery when different technologies are used in a) the coverage of root and implant dehiscences, b) the augmentation of keratinized tissue (KT) and c) the augmentation of soft tissue volume.
  
  
  METHODS
  An electronic search from The National Library of Medicine (MEDLINE-PubMed) was performed: English articles with research focus in oral soft tissue regeneration, providing histological outcomes, either from animal experimental studies or human biopsy material were included.
  
  
  RESULTS
  Barrier membranes, enamel matrix derivatives, growth factors, allogeneic and xenogeneic soft tissue substitutes have been used in soft tissue regeneration demonstrating different degrees of regeneration. In root coverage, these technologies were able to improve new attachment, although none has shown complete regeneration. In KT augmentation, tissue-engineered allogenic products and xenogeneic collagen matrixes demonstrated integration within the host connective tissue and promotion of keratinization. In soft tissue augmentation and peri-implant plastic surgery there are no histological data currently available.
  
  
  CONCLUSIONS
  Soft tissue substitutes, growth differentiation factors demonstrated promising histological results in terms of soft tissue regeneration and keratinization, whereas there is a need for further studies to prove their added value in soft tissue augmentation.
authors.affiliation: Department of Periodontology, University Complutense of Madrid, Madrid, Spain.
authors.forename: Fabio
authors.initials: F
authors.lastname: Vignoletti
authors.forename: Javier
authors.initials: J
authors.lastname: Nunez
authors.forename: Mariano
authors.initials: M
authors.lastname: Sanz
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use*; D015921:Dental Implants; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D007575:Jaw, Edentulous / Q000601:surgery*; D007633:Keratins; D008567:Membranes, Artificial; D010510:Periodontal Diseases / Q000601:surgery; D010519:Periodontium / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods; D023822:Tissue Engineering / Q000379:methods; D014070:Tooth / Q000601:surgery*; D014092:Tooth Root / Q000601:surgery; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D015921:Dental Implants; D036341:Intercellular Signaling Peptides and Proteins; D008567:Membranes, Artificial; D007633:Keratins
keywords: barrier membranes; biologicals; cell therapy; histology; keratinized tissue; mucogingival surgery; recession defect; root coverage; scaffolds; wound healing