title: Bone scan or (18)f-fluorodeoxyglucose positron emission tomography/computed tomography; which modality better shows bone metastases of breast cancer?
abstract: BACKGROUND
  In this multicenter study, we aimed to compare concurrent (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and bone scan results of breast cancer patient.
  
  
  METHODS
  162 patients with breast cancer (158 female, 4 male; mean age 50.6 years) were included in the study. FDG PET/CT examination was performed in all patients, and concurrent bone scintigraphy in 68 patients. The results of FDG PET/CT and bone scan were compared.
  
  
  RESULTS
  132 of the 162 patients were operated on because of breast cancer. 89 patients had metastasis, and 4 had recurrent disease according to FDG PET/CT results. Metastatic sites in order of frequency were lymph nodes, bone, lung, liver, adrenal gland, local skin or muscle, brain, and peritoneum (peritonitis carcinomatosa). The sensitivity, specificity, accuracy, and negative and positive predictive value of bone scintigraphy versus FDG PET/CT were 96 vs. 100%, 100 vs. 98%, 100 vs. 83%, 100 vs. 100%, and 90 vs. 100%, respectively.
  
  
  CONCLUSIONS
  Although the 2 modalities were in concordance with each other, in 5 (21%) cases, FDG PET/CT could not show bone metastasis which were detected on bone scintigraphy. Hence, bone scintigraphy was superior to FDG PET/CT in the determination of bone metastasis derived from breast cancer. However, FDG PET/CT should be considered for soft tissue metastasis.
authors.affiliation: Department of Nuclear Medicine, Damla Hospital, Elazig, Diyarbakir, Turkey.
authors.forename: Tansel A
authors.initials: TA
authors.lastname: Balci
authors.affiliation: Department of Nuclear Medicine, Firat (Euphrates) University Medical Faculty, Elazig, Diyarbakir, Turkey.
authors.forename: Zehra P
authors.initials: ZP
authors.lastname: Koc
authors.affiliation: Department of Nuclear Medicine, Training Hospital, Diyarbakir, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Komek
keywords: Bone metastasis; Bone scintigraphy; Breast cancer; FDG PET/CT