title: N-cadherin and P-cadherin are biomarkers for invasion, metastasis, and poor prognosis of gallbladder carcinomas.
abstract: Gallbladder cancer (GBC) is a rare, but highly aggressive cancer. The most common type of gallbladder cancer is adenocarcinoma (AC), while squamous cell/adenosquamous carcinoma (SC/ASC) is a rare type of gallbladder cancer. The clinicopathologic and biological characteristics of SC/ASC have not been well documented. In this study, the protein expression of N-cadherin and P-cadherin in 46 SC/ASCs and 80 ACs was measured using immunohistochemistry. We demonstrated that positive N-cadherin and P-cadherin expression were significantly associated with large tumor size, invasion, and lymph node metastasis of both SC/ASC and AC. In contrast, positive N-cadherin and P-cadherin expression were significantly associated with differentiation and TNM stage in only AC. Univariate Kaplan-Meier analysis showed that positive N-cadherin and P-cadherin expression, differentiation, tumor size, TNM stage, invasion, lymph node metastasis, and surgical curability were significantly associated with overall survival in both SC/ASC and AC patients. Multivariate Cox regression analysis showed that positive N-cadherin and P-cadherin expression are independent poor-prognostic factors in both SC/ASC and AC patients. Our study suggested that positive N-cadherin and P-cadherin expression closely correlated with clinicopathological and biological behaviors, and poor-prognosis of gallbladder cancer.
authors.affiliation: Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Shengen
authors.initials: S
authors.lastname: Yi
authors.affiliation: Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China. Electronic address: yangzhulin8@sina.com.
authors.forename: Zhu-Lin
authors.initials: ZL
authors.lastname: Yang
authors.affiliation: Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Xiongying
authors.initials: X
authors.lastname: Miao
authors.affiliation: Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zou
authors.affiliation: Department of Pathology, Basic Medical Science College, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Jinghe
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary and Pancreatic Surgery, Hunan Provincial People's Hospital, Changsha, Hunan 410007, PR China.
authors.forename: Lufeng
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Pathology, Loudi Central Hospital, Loudi, Hunan 417011, PR China.
authors.forename: Guixiang
authors.initials: G
authors.lastname: Zeng
authors.affiliation: Department of Pathology, Hunan Provincial Tumor Hospital, Changsha, Hunan 410013, PR China.
authors.forename: Senlin
authors.initials: S
authors.lastname: Chen
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000556:secondary; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D015820:Cadherins / Q000032:analysis*; D018196:Carcinoma, Adenosquamous / Q000737:chemistry* / Q000556:secondary; D002454:Cell Differentiation; D005260:Female; D005706:Gallbladder Neoplasms / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D013997:Time Factors; D047368:Tumor Burden
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C050361:CDH2 protein, human; C512197:CDH3 protein, human; D015820:Cadherins
keywords: Adenocarcinoma; Adenosquamous carcinoma; Gallbladder cancer; Metastasis; N-cadherin; P-cadherin; Prognosis; Squamous cell carcinoma