title: Correlation of ovalbumin of egg white components with allergic diseases in children.
abstract: BACKGROUND
  Immunoglobulin E (IgE)-mediated food allergy, such as egg white allergy, is common in young children (<3 years old), but not all young children sensitive to egg white present with allergic symptoms. This study investigated the relationship between sensitization to egg white component allergens and clinical manifestations of allergic diseases in young children.
  
  
  METHODS
  From March to December 2010, 2256 children with physician-diagnosed allergic diseases were tested for serum levels of egg white, ovalbumin, and ovomucoid-specific IgE in the Pediatric Allergy and Asthma Center of Chang Gung Memorial Hospital. Serum was analyzed for specific IgE antibodies to egg white, ovalbumin, and ovomucoid by ImmunoCAP (Phadia, Uppsala, Sweden). Allergen-specific IgE levels ≥0.35 kUA/L were defined as positive.
  
  
  RESULTS
  There was a significantly higher sensitization rate to egg white and its components in children aged 2-4 years old. The sensitization rate to egg white, ovalbumin, and ovomucoid in this age group was 53.5%, 48.3%, and 37.2%, respectively, and the trend of the sensitization decreased with age (p < 0.001). After adjusting for age, sensitization to egg white and ovalbumin was associated with children with dermatitis [egg white: odds ratio (OR) = 1.28, 95% confidence intervals (CI) = 1.03-1.58, p < 0.05; ovalbumin: OR = 1.30, 95% CI = 1.04-1.62, p < 0.05]. Children with ovomucoid sensitization had no statistically significant risk among different groups in the current study.
  
  
  CONCLUSIONS
  Children aged 2-4 years old have higher sensitivity to egg white, ovalbumin, and ovomucoid. Children with egg white and ovalbumin sensitization have a higher risk for atopic dermatitis, and ovalbumin has a more important contribution. Furthermore, we suggested that in children with atopic dermatitis, if they are aged 2-4 years old and are having egg white and ovalbumin sensitization, avoiding eating raw or slightly heated eggs might have a beneficial effect.
authors.affiliation: Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkuo, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Yang-Te
authors.initials: YT
authors.lastname: Lin
authors.affiliation: Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkuo, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Chih-Te
authors.initials: CT
authors.lastname: Wu
authors.affiliation: Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkuo, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Jing-Long
authors.initials: JL
authors.lastname: Huang
authors.affiliation: Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkuo, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Ju-Hui
authors.initials: JH
authors.lastname: Cheng
authors.affiliation: Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkuo, Chang Gung University, Taoyuan, Taiwan. Electronic address: kwyeh@adm.cgmh.org.tw.
authors.forename: Kuo-Wei
authors.initials: KW
authors.lastname: Yeh
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000485:Allergens / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004529:Egg White; D005260:Female; D005512:Food Hypersensitivity / Q000453:epidemiology*; D006801:Humans; D007118:Immunoassay; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D008297:Male; D010047:Ovalbumin / Q000276:immunology*; D013548:Sweden
chemical_list: D000485:Allergens; D007073:Immunoglobulin E; D010047:Ovalbumin
keywords: Allergen component; Egg white; Sensitization