title: The effects of chemotherapy on primary small bowel cancer: A retrospective multicenter observational study in Japan.
abstract: Small bowel cancer is relatively rare among gastrointestinal tract cancers, including esophageal, gastric and colorectal cancers. The majority of cases of small bowel cancer are diagnosed at an advanced stage, resulting in poor outcomes. The clinical effects of chemotherapy on small bowel cancer have been investigated in a limited number of studies from Europe and the USA. However, they have not yet been fully investigated in Asian countries, including Japan. This retrospective multicenter observational study was designed to investigate the efficacy of chemotherapy on small bowel cancer. A questionnaire survey was conducted in 28 hospitals affiliated with the Osaka University Hospital. We retrospectively reviewed the medical records of 61 patients with small bowel cancer (32 patients who were unable to undergo curative resection or had unresectable distant metastases and 29 who underwent curative resection), treated between 1996 and 2009, to evaluate the outcomes and the efficacy of chemotherapy. There was no significant difference in the overall survival between the patients undergoing curative resection with postoperative adjuvant chemotherapy and those without postoperative adjuvant chemotherapy. In patients with non-curative resection or unresectable distant metastases, the response rate to chemotherapy was 31.6% and the overall survival was significantly higher compared to that without chemotherapy (P=0.008). The study results suggested that chemotherapy is effective for Japanese patients with small bowel cancer who cannot undergo curative resection or have unresectable distant metastases.
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Mizushima
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Osaka General Medical Center, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tamagawa
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Unit of Cancer Center, Aichi Medical University, Aichi, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Mishima
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Minoh City Hospital, Osaka, Japan.
authors.forename: Kimimasa
authors.initials: K
authors.lastname: Ikeda
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Social Insurance Kinan Hospital, Wakayama, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Fujita
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Osaka Police Hospital, Osaka, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Akamatsu
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ikenaga
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, NTT West Osaka Hospital, Osaka, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Onishi
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Sakai City Hospital, Osaka, Japan.
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Fukunaga
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Ikeda City Hospital, Osaka, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Fukuzaki
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Osaka Rosai Hospital, Osaka, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Hasegawa
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Takemasa
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Ikeda
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yamamoto
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Sekimoto
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Osaka Rosai Hospital, Osaka, Japan.
authors.forename: Riichiro
authors.initials: R
authors.lastname: Nezu
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Doki
authors.affiliation: Clinical Study Group of Osaka University (CSGO), Colorectal Group, Osaka, Japan ; Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
keywords: adjuvant chemotherapy; palliative chemotherapy; retrospective chart review; small bowel cancer