title: Psychiatric symptoms in boys with fragile X syndrome: a comparison with nonsyndromic autism spectrum disorder.
abstract: In the present study, we examined the profile of psychiatric symptoms in boys with fragile X syndrome (FXS) using a parent report instrument. In addition, by comparing boys with FXS to boys with nonsyndromic autism spectrum disorder (ASD) utilizing multiple matching strategies, we examined between-group differences in the types of psychiatric symptoms observed and in the strength of their concurrent associations. Across all matching strategies, symptoms of manic/hyperactive behaviors and general anxiety were more frequently reported for boys with FXS than for boys with nonsyndromic ASD. Results also indicated a positive association between social avoidance and general anxiety in FXS that was stronger than that observed in nonsyndromic ASD across all matching strategies. Theoretical and treatment implications are discussed.
authors.affiliation: MIND Institute, University of California, Davis, United States; Department of Psychiatry and Behavioral Sciences, University of California, Davis, United States. Electronic address: angela.thurman@ucdmc.ucdavis.edu.
authors.forename: Angela John
authors.initials: AJ
authors.lastname: Thurman
authors.affiliation: MIND Institute, University of California, Davis, United States; Department of Psychiatry and Behavioral Sciences, University of California, Davis, United States.
authors.forename: Andrea
authors.initials: A
authors.lastname: McDuffie
authors.affiliation: MIND Institute, University of California, Davis, United States; Department of Pediatrics, University of California, Davis, United States.
authors.forename: Randi
authors.initials: R
authors.lastname: Hagerman
authors.affiliation: MIND Institute, University of California, Davis, United States; Department of Psychiatry and Behavioral Sciences, University of California, Davis, United States.
authors.forename: Leonard
authors.initials: L
authors.lastname: Abbeduto
mesh_terms: D001007:Anxiety / Q000523:psychology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000523:psychology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000523:psychology*; D002675:Child, Preschool; D003192:Compulsive Behavior / Q000523:psychology; D005600:Fragile X Syndrome / Q000523:psychology*; D006801:Humans; D008297:Male; D009770:Obsessive Behavior / Q000523:psychology; D012919:Social Behavior
keywords: Anxiety; Autism spectrum disorder; Fragile X syndrome; Hyperactivity; Psychiatric symptoms; Social avoidance