title: Quality control: ER-associated degradation: protein quality control and beyond.
abstract: Even with the assistance of many cellular factors, a significant fraction of newly synthesized proteins ends up misfolded. Cells evolved protein quality control systems to ensure that these potentially toxic species are detected and eliminated. The best characterized of these pathways, the ER-associated protein degradation (ERAD), monitors the folding of membrane and secretory proteins whose biogenesis takes place in the endoplasmic reticulum (ER). There is also increasing evidence that ERAD controls other ER-related functions through regulated degradation of certain folded ER proteins, further highlighting the role of ERAD in cellular homeostasis.
authors.affiliation: Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG), 88 08003 Barcelona, Spain.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Ruggiano
authors.forename: Ombretta
authors.initials: O
authors.lastname: Foresti
authors.forename: Pedro
authors.initials: P
authors.lastname: Carvalho
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000201:enzymology; D060746:Endoplasmic Reticulum-Associated Degradation; D006801:Humans; D011485:Protein Binding; D017510:Protein Folding; D011506:Proteins / Q000378:metabolism*; D059748:Proteolysis; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D011506:Proteins; D044767:Ubiquitin-Protein Ligases