title: The role of coronary artery disease in heart failure.
abstract: Enhanced survival following acute myocardial infarction and the declining prevalence of hypertension and valvular heart disease as contributors to incident heart failure (HF) have fueled the emergence of coronary artery disease (CAD) as the primary risk factor for HF development. Despite the acknowledged role of CAD in the development of HF, the role of coronary revascularization in reducing HF-associated morbidity and mortality remains controversial. The authors review key features of the epidemiology and pathophysiology of CAD in patients with HF as well as the emerging data from recent clinical trials that inform the modern approach to management.
authors.affiliation: Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY, USA.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Lala
authors.affiliation: Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: ADESAI@PARTNERS.ORG.
authors.forename: Akshay S
authors.initials: AS
authors.lastname: Desai
mesh_terms: D003324:Coronary Artery Disease / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D006333:Heart Failure / Q000209:etiology* / Q000628:therapy; D006801:Humans; D011379:Prognosis
keywords: Coronary artery disease; Coronary revascularization; Heart failure; Myocardial infarction