title: Insights into the mechanistic and synthetic aspects of the Mo/P-catalyzed oxidation of N-heterocycles.
abstract: A Mo/P catalytic system for an efficient gram-scale oxidation of a variety of nitrogen heterocycles to N-oxides with hydrogen peroxide as terminal oxidant has been investigated. Combined spectroscopic and crystallographic studies point to the tetranuclear Mo4P peroxo complex as one of the active catalytic species present in the solution. Based on this finding an optimized catalytic system has been developed. The utility and chemoselectivity of the catalytic system has been demonstrated by the synthesis of over 20 heterocyclic N-oxides.
authors.affiliation: Department of Chemistry, University of Texas at San Antonio, San Antonio, Texas, USA. oleg.larionov@utsa.edu.
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Larionov
authors.forename: David
authors.initials: D
authors.lastname: Stephens
authors.forename: Adelphe M
authors.initials: AM
authors.lastname: Mfuh
authors.forename: Hadi D
authors.initials: HD
authors.lastname: Arman
authors.forename: Anastasia S
authors.initials: AS
authors.lastname: Naumova
authors.forename: Gabriel
authors.initials: G
authors.lastname: Chavez
authors.forename: Behije
authors.initials: B
authors.lastname: Skenderi
mesh_terms: D002384:Catalysis; D055808:Drug Discovery; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D008982:Molybdenum / Q000737:chemistry*; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry; D010758:Phosphorus / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry
chemical_list: D006571:Heterocyclic Compounds; D008024:Ligands; D010087:Oxides; D010720:Phosphines; D011804:Quinolines; D010758:Phosphorus; D008982:Molybdenum; C044646:phosphine