title: Ethanol extract of lotus (Nelumbo nucifera) root exhibits an anti-adipogenic effect in human pre-adipocytes and anti-obesity and anti-oxidant effects in rats fed a high-fat diet.
abstract: Lotus (Nelumbo Nucifera) root, a well-known medicinal plant in Asia, is reported to have various therapeutic benefits, including anti-diabetes, anti-hypertension, and anti-hyperlipidaemia. We hypothesized that the ethanol extract of lotus root (ELR) would exhibit an anti-adipogenic effect in human pre-adipocytes as well as anti-obesity and anti-oxidant effects in rats fed a high-fat diet. Treatment with ELR in human pre-adipocytes resulted in inhibition of lipid accumulation and attenuated expression of adipogenic transcription factors such as peroxisome proliferator-activated receptor gamma and adipocyte marker genes, such as glucose transporter 4 and leptin. Administration of ELR resulted in a significant decrease in relative weights of adipose tissues in rats fed a high-fat diet. Consumption of a high-fat diet resulted in an increase in serum total cholesterol (TC) and triglyceride (TG) levels; however, administration of ELR resulted in a decrease in the levels of TC and TG. Administration of ELR resulted in a decrease in the level of serum leptin and insulin. Administration of ELR in rats fed a high-fat diet resulted in a decrease in hepatic thiobarbituric acid reactive substance content, elevated by a high-fat diet and an increase in superoxide dismutase activity and hepatic glutathione content. These results suggest that lotus root exerts anti-oxidant and anti-obesity effects and could be used as a functional and nutraceutical ingredient in combatting obesity-related diseases.
authors.affiliation: Department of Food and Nutrition, Inha University, 100 Inha-ro, Nam-gu, Incheon, 402-751, Republic of Korea.
authors.forename: Jeong Soon
authors.initials: JS
authors.lastname: You
authors.affiliation: Department of Food and Nutrition, Inha University, 100 Inha-ro, Nam-gu, Incheon, 402-751, Republic of Korea.
authors.forename: Yun Ju
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: East-west Bone & Joint Disease Research Institute, Kyung Hee University Hospital at Gangdong, 149 Sangil-dong, Gangdong-gu, Seoul, 134-727, Republic of Korea.
authors.forename: Kyoung Soo
authors.initials: KS
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 143-701, Republic of Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Food and Nutrition, Inha University, 100 Inha-ro, Nam-gu, Incheon, 402-751, Republic of Korea. Electronic address: kjchang@inha.ac.kr.
authors.forename: Kyung Ja
authors.initials: KJ
authors.lastname: Chang
mesh_terms: D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism; D054392:Adipokines / Q000097:blood; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002478:Cells, Cultured; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002149:Energy Intake / Q000187:drug effects; D005419:Flavonoids / Q000032:analysis; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D031653:Nelumbo / Q000737:chemistry*; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000032:analysis; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
chemical_list: D054392:Adipokines; D019440:Anti-Obesity Agents; D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005419:Flavonoids; D007328:Insulin; D020738:Leptin; D010636:Phenols; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: Adipocyte; Ani-oxidant; Anti-obesity; Lotus (Nelumbo Nucifera) root; Rat