title: Effect of intramural myomectomy on endometrial HOXA10 and HOXA11 mRNA expression at the time of implantation window.
abstract: BACKGROUND
  HOXA11 and HOXA10 are expressed in endometrium throughout the menstrual cycle and show a dramatic increase during the mid-luteal phase at the time of implantation. The expression of these genes is decreased in women with myomas.
  
  
  OBJECTIVE
  To determine whether myomectomy would reverse HOXA11 and HOXA10 expression, we evaluated the transcript levels of these genes in the endometria of patients before and after myomectomy.
  
  
  METHODS
  Expression of HOXA11 and HOXA10 were examined prospectively during the midluteal phase in endometrium obtained from infertile women (n=12) with myoma before and three months after myomectomy. Endometrial HOXA11 and HOXA10 expression were evaluated using quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR).
  
  
  RESULTS
  Endometrial HOXA11 and HOXA10 mRNAs expression levels (normalized to 18SrRNA) were increased insignificantly in endometrium of patients after myomectomy (p=0.7 and p=0.15 respectively).
  
  
  CONCLUSIONS
  The results suggest that the alteration in expression pattern of these genes could not account for some aspects of fertility after myomectomy. This article extracted from M.Sc. thesis. (Shamila Faramarzi).
authors.affiliation: Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Alizadeh
authors.affiliation: Department of Obstetrics and Gynecology, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Shamila
authors.initials: S
authors.lastname: Faramarzi
authors.affiliation: Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Massoud
authors.initials: M
authors.lastname: Saidijam
authors.affiliation: Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Alizamir
authors.affiliation: Department of Epidemiology, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Esna-Ashari
authors.affiliation: Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Nooshin
authors.initials: N
authors.lastname: Shabab
authors.affiliation: Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Farimani Sanoee
keywords: Embryo Implantation; Endometrium; HOXA10; HOXA11; Myoma; Uterine myomectomy