title: A universal approach to crosslinked hierarchical polymer multilayers as stable and highly effective antifouling coatings.
abstract: Material-independent and bioinert hierarchical polymer multilayer coatings are presented. Chemically active catecholic hyperbranched polyglycerols (hPGs) form a foundation layer on a versatile surface via multivalent anchoring and crosslinking, the activity of which is shielded by the bioinert catecholic hPGs. Mono-catecholic hPGs finally terminate all of the free catechols to build a flexible bioinert top layer. These coatings perfectly prevent protein and cell adhesion.
authors.affiliation: Department of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany; Helmholtz Virtual Institute, Multifunctional Biomaterials for Medicine, Kantstraße 55, 14513, Teltow-Seehof, Germany.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.forename: Tobias
authors.initials: T
authors.lastname: Becherer
authors.forename: Paul-Ludwig Michael
authors.initials: PL
authors.lastname: Noeske
authors.forename: Ingo
authors.initials: I
authors.lastname: Grunwald
authors.forename: Rainer
authors.initials: R
authors.lastname: Haag
mesh_terms: D000327:Adsorption; D000818:Animals; D002396:Catechols / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis*; D004866:Equipment Contamination / Q000517:prevention & control*; D005990:Glycerol / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D041681:NIH 3T3 Cells; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D002396:Catechols; D020099:Coated Materials, Biocompatible; D011108:Polymers; D011506:Proteins; C043941:polyglycerol; D005990:Glycerol
keywords: antifouling; hierarchical multilayer architecture; hyperbranched polyglycerol; protein resistance; surface modification