title: The A10389G polymorphism ofND3gene and breast cancer: A meta-analysis.
abstract: Previous studies have reported the association between A10389G polymorphism of thedehydrogenase subunit 3(ND3) gene and breast cancer risk with conflicting results. To explore this association, we conducted a meta-analysis on 5,580 patients and 5,749 controls from eligible published studies. Six reports (11 study populations) were included in this meta-analysis. Compared with the individuals with the G allele, individuals carrying the A allele did not exhibit increased breast cancer risk. The odds ratio (OR) and 95% confidence interval (CI) were 1.02 and 0.79-1.31, respectively. Stratified analyses were carried out according to ethnicity and source of controls. The corresponding ORs (95% CIs) were 1.20 (0.90-1.86) for African-American, 0.47 (0.03-7.64) for European and 0.89 (0.70-1.14) for mixed populations, respectively. A single study on Asian populations yielded an OR (95% CI) of 0.56 (0.32-1.00). The corresponding ORs (95% CIs) were 1.12 (0.23-5.47) for hospital-based studies, and 0.98 (0.76-1.27) for population-based studies. Only one study did not mention the source of control, the OR (95% CI) of which was 1.80 (1.15-2.82). Results of the present study suggested that theND3gene A10389G polymorphism may not be an independent risk factor for breast cancer. However, additional studies should be performed to clarify the possible roles of theND3A10398G polymorphism in the etiology of breast cancer.
authors.affiliation: National Research Institute for Family Planning, General Hospital of Chinese People's Liberation Army, Beijing;
authors.forename: Qunxia
authors.initials: Q
authors.lastname: Mao
authors.affiliation: Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing;
authors.forename: Linggen
authors.initials: L
authors.lastname: Gao
authors.affiliation: National Research Institute for Family Planning, General Hospital of Chinese People's Liberation Army, Beijing;
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: National Research Institute for Family Planning, General Hospital of Chinese People's Liberation Army, Beijing;
authors.forename: Yan
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Hangzhou Centre for Disease Control and Prevention, Zhejiang;
authors.forename: Xvhui
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Safety Engineering, China Institute of Industrial Relations, Chinese Academy of Medical Sciences and Peking Union Medical College; Beijing, P.R. China ;
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.affiliation: Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College; Beijing, P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: National Research Institute for Family Planning, General Hospital of Chinese People's Liberation Army, Beijing;
authors.forename: Hua
authors.initials: H
authors.lastname: Yu
keywords: A10389G polymorphism; breast cancer; dehydrogenase subunit 3 gene; meta-analysis