title: Gene expression of androgen metabolising enzymes in benign prostatic hyperplasia.
abstract: Benign prostatic hyperplasia is still one of the most important problems of modern urology. We studied the gene expression of androgen metabolic enzymes involved in the synthesis of androgens directly in the target organs in 20 patients using real-time RP-PCR. A significant increase in the mRNA of HSD1 7B3 approximately 1,7 fold, SRD5A2 approximately 2 fold, HSD3B1 approximately 2 fold, STS approximately 2,3 fold u AR -2.5 fold and reduced HSD17B2 approximately 4 fold in samples of tumor tissue compared with adjacent tissues.
authors.forename: A A
authors.initials: AA
authors.lastname: Otpuschennikov
authors.forename: E P
authors.initials: EP
authors.lastname: Khvostova
authors.forename: C E
authors.initials: CE
authors.lastname: Krasilnikov
authors.forename: L F
authors.initials: LF
authors.lastname: Gulyaeva
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000235:genetics / Q000378:metabolism*; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000235:genetics / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D000728:Androgens / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism*; D011375:Progesterone Reductase / Q000235:genetics / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000201:enzymology* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013251:Steroid Isomerases / Q000235:genetics / Q000378:metabolism*; D043266:Steryl-Sulfatase / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: C021425:3 beta-hydroxysteroid oxidoreductase-delta(5) 3-ketosteroid isomerase; D000728:Androgens; D008565:Membrane Proteins; D009097:Multienzyme Complexes; D012333:RNA, Messenger; D015067:17-Hydroxysteroid Dehydrogenases; C476565:17beta-hydroxysteroid dehydrogenase type 3; D011375:Progesterone Reductase; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; C548468:SRD5A2 protein, human; C584039:STS protein, human; D043266:Steryl-Sulfatase; D013251:Steroid Isomerases