title: Bioabsorbable implant as a tracheal wall substitute in young developing canines.
abstract: This study evaluated a polylactic and polyglycolic acid (PLA/PGA) implant as a partial tracheal substitute in young developing canines. This experimental and longitudinal study included local stray pups that received substitution of a short cervical tracheal segment with a PLA 85%/PGA 15% plaque. We measured clinical, endoscopic, and tomographic variables for 1 year, at which time we performed histomorphological evaluations of the implant using light and electron microscopy. There were no adverse events throughout the clinical progression. On endoscopic evaluation, the implant was covered with mucosal tissue beginning in the first month, without granulation or stenosis, and the circular shape of the trachea was altered. Tomographic images of the tracheal area at the implant site were similar to adjacent healthy areas (p = 0.423). At the end of the follow-up period, the plaque had biodegraded, and the space was covered by pseudostratified epithelium and ciliated cells similar to the neighboring tissue. Implantation of a PLA/PGA plaque constituted an effective (functional) replacement of a short semicircular cervical tracheal segment without limiting the growth of the recipient. Additional studies are required to prove the efficacy of these implants for larger tracheal segment replacements and in subjects at different stages of development.
authors.affiliation: From the *PhD Graduate Program in Biological and Health Sciences, Metropolitan Autonomous University, México City, México; †Experimental Surgery Department, National Pediatric Institute (INP), México City, México; ‡Bioacoustics Laboratory, National Rehabilitation Institute (INR), México City, México; §Surgery Department, National Autonomous University of Mexico, México City, México; ¶Imaging Department, Multicut Computerized Tomography Service, INP, México City, México; ‖Laboratory of Electronic Microscopy, INP, México City, México; and #Agricultural and Animal Production, Metropolitan Autonomous University, México City, México.
authors.forename: Rosa E
authors.initials: RE
authors.lastname: Soriano-Rosales
authors.forename: Beatriz E
authors.initials: BE
authors.lastname: Perez-Guille
authors.forename: Emilio
authors.initials: E
authors.lastname: Arch-Tirado
authors.forename: Alfonso
authors.initials: A
authors.lastname: Alfaro-Rodriguez
authors.forename: Fernando
authors.initials: F
authors.lastname: Villegas-Alvarez
authors.forename: Jose F
authors.initials: JF
authors.lastname: Gonzalez-Zamora
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Jimenez-Bravo
authors.forename: Sandra
authors.initials: S
authors.lastname: Zaragoza-Huerta
authors.forename: Angelica
authors.initials: A
authors.lastname: Gonzalez-Maciel
authors.forename: Andrea
authors.initials: A
authors.lastname: Ramos-Morales
authors.forename: Rafael
authors.initials: R
authors.lastname: Reynoso-Robles
authors.forename: Daniel
authors.initials: D
authors.lastname: Mota-Rojas
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D019344:Lactic Acid; D008137:Longitudinal Studies; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011474:Prosthesis Design; D014135:Tracheal Stenosis / Q000601:surgery*
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid