title: Cutaneous extranodal natural killer/T-cell lymphoma: a comparative clinicohistopathologic and survival outcome analysis of 45 cases according to the primary tumor site.
abstract: BACKGROUND
  Differences in survival outcomes and prognostic factors of cutaneous extranodal natural killer/T-cell lymphoma (ENKTL) depending on primary tumor site are currently unknown.
  
  
  OBJECTIVE
  We sought to analyze the clinicopathological features and survival outcomes of cutaneous ENKTL according to primary tumor site.
  
  
  METHODS
  In all, 45 patients with cutaneous ENKTL were classified with: (1) primary cutaneous ENKTL, or (2) nasal ENKTL with cutaneous involvement. Clinicopathologic features, survival outcomes, and prognostic factors were analyzed using patient's medical records. Survival outcomes were analyzed using the Kaplan-Meier method and compared using the log rank test. The Student t test, Fisher exact test, and linear by linear association test were used to analyze clinicopathologic differences between groups.
  
  
  RESULTS
  Clinical manifestations of cutaneous ENKTL included solitary or multiple subcutaneous nodules and cellulitis or abscess-like lesions. Primary cutaneous ENKTL demonstrated a less aggressive clinical course and better survival outcomes. The extent of cutaneous lesions demonstrated a significant effect on the prognosis of primary cutaneous ENKTL, but not on nasal ENKTL with cutaneous involvement. The presence of nasal lesions in primary cutaneous ENKTL was associated with poor prognosis.
  
  
  CONCLUSIONS
  This study used a retrospective design and included a small sample size.
  
  
  CONCLUSIONS
  Although the clinicopathological features were similar regardless of subgroup, survival outcomes and prognostic factors differed depending on the primary tumor site of cutaneous ENKTL.
authors.affiliation: Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine.
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Lee
authors.affiliation: Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine.
authors.forename: Joon Min
authors.initials: JM
authors.lastname: Jung
authors.affiliation: Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine.
authors.forename: Chong Hyun
authors.initials: CH
authors.lastname: Won
authors.affiliation: Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine.
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Chang
authors.affiliation: Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine.
authors.forename: Jee Ho
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine.
authors.forename: Kee
authors.initials: K
authors.lastname: Chan Moon
authors.affiliation: Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine.
authors.forename: Chan-Sik
authors.initials: CS
authors.lastname: Park
authors.affiliation: Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine.
authors.forename: Jooryung
authors.initials: J
authors.lastname: Huh
authors.affiliation: Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine. Electronic address: jijulee@hanmail.net.
authors.forename: Mi Woo
authors.initials: MW
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D015331:Cohort Studies; D003131:Combined Modality Therapy / Q000379:methods; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D055815:Young Adult
keywords: cutaneous lesion; extranodal natural killer/T-cell lymphoma; prognostic factor; skin; survival outcome; tumor site