title: Combined antibacterial effects of tissue-tolerable plasma and a modern conventional liquid antiseptic on chronic wound treatment.
abstract: Potential antimicrobial effects of sequential applications of tissue-tolerable plasma (TTP) and the conventional liquid antiseptic octenidine dihydrochloride (ODC) were investigated. 34 patients with chronic leg ulcers were treated with TTP, ODC or a combination of both. The bacterial colonization was measured semi-quantitatively before and immediately after treatment and changes in the microbial strains' compositions before and after antiseptic treatments were analyzed. All antiseptic procedures reduced the bacterial counts significantly. The sequential application of TTP and ODC displayed the highest antimicrobial efficacy. Me combined use of TTP and conventional antiseptics might represent the most efficient strategy for antiseptic treatment of chronic wounds.
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Allergology and Venerology, Berlin, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Klebes
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Allergology and Venerology, Berlin, Germany.
authors.forename: Christin
authors.initials: C
authors.lastname: Ulrich
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Allergology and Venerology, Berlin, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Kluschke
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Allergology and Venerology, Berlin, Germany.
authors.forename: Alexa
authors.initials: A
authors.lastname: Patzelt
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Allergology and Venerology, Berlin, Germany.
authors.forename: Staffan
authors.initials: S
authors.lastname: Vandersee
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Allergology and Venerology, Berlin, Germany.
authors.forename: Heike
authors.initials: H
authors.lastname: Richter
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Allergology and Venerology, Berlin, Germany.
authors.forename: Adrienne
authors.initials: A
authors.lastname: Bob
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Allergology and Venerology, Berlin, Germany.
authors.forename: Johanna
authors.initials: J
authors.lastname: von Hutten
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Allergology and Venerology, Berlin, Germany.
authors.forename: Jorien T
authors.initials: JT
authors.lastname: Krediet
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Allergology and Venerology, Berlin, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Kramer
authors.affiliation: Ernst-Moritz-Arndt-University Greifswald, Medical Faculty, Institute of Hygiene and Environmental Medicine, Greifswald, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Lademann
authors.affiliation: Charité - Universitätsmedizin Berlin, Department of Dermatology, Allergology and Venerology, Berlin, Germany. juergen.lademann@charite.de.|Klinikum - Klagenfurt am Wörthersee, Feschnigstraße 11, 9020, Klagenfurt, Austria. juergen.lademann@charite.de.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Lange-Asschenfeld
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D004347:Drug Interactions; D005122:Exudates and Transudates / Q000187:drug effects; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced; D058626:Plasma Gases / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D058626:Plasma Gases
keywords: antiseptic efficacy; chronic wounds; octenidine dihydrochloride (ODC); tissue tolerable plasma (TTP); wound disinfection