title: A case of pneumonia caused by Legionella pneumophila serogroup 12 and treated successfully with imipenem.
abstract: The patient was an 83-year-old man hospitalized for Haemophilus influenzae pneumonia, who developed recurrent pneumonia after improvement of the initial episode. Legionella pneumophila serogroup 12 was isolated from the sputum, accompanied by increased serum antibody titers to L. pneumophila serogroup 12. Therefore, the patient was diagnosed as having Legionella pneumonia caused by L. pneumophila serogroup 12. Case reports of pneumonia caused by L. pneumophila serogroup 12 are rare, and the case described herein is the first report of clinical isolation of this organism in Japan. When the genotype was determined by the protocol of The European Working Group for Legionella Infections (Sequence-Based Typing [SBT] for epidemiological typing of L. pneumophila, Version 3.1), the sequence type was ST68. Imipenem/cilastatin therapy was found to be effective for the treatment of Legionella pneumonia in this patient.
authors.affiliation: Department of Respiratory Medicine, Saiseikai Yamagata Saisei Hospital, Japan.
authors.forename: Midori
authors.initials: M
authors.lastname: Nishizuka
authors.affiliation: Department of Respiratory Medicine, Saiseikai Yamagata Saisei Hospital, Japan. Electronic address: hiroki-s@ma.catvy.ne.jp.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Department of Respiratory Medicine, Saiseikai Yamagata Saisei Hospital, Japan.
authors.forename: Tomoka
authors.initials: T
authors.lastname: Ara
authors.affiliation: Department of Respiratory Medicine, Saiseikai Yamagata Saisei Hospital, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Department of Respiratory Medicine, Saiseikai Yamagata Saisei Hospital, Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Morita
authors.affiliation: Department of Respiratory Medicine, Saiseikai Yamagata Saisei Hospital, Japan.
authors.forename: Chisa
authors.initials: C
authors.lastname: Sato
authors.affiliation: Department of Respiratory Medicine, Saiseikai Yamagata Saisei Hospital, Japan.
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Tsuchida
authors.affiliation: Department of Microbiology, Yamagata Prefectural Institute of Public Health, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Seto
authors.affiliation: Department of Bacteriology I, National Institute of Infectious Diseases, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Amemura-Maekawa
authors.affiliation: Department of Bacteriology I, National Institute of Infectious Diseases, Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Kura
authors.affiliation: Department of Respiratory Medicine, Saiseikai Yamagata Saisei Hospital, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takeda
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use*; D007564:Japan; D016952:Legionella pneumophila / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D007877:Legionnaires' Disease / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D012703:Serotyping; D013183:Sputum / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem
keywords: Imipenem/cilastatin; Legionella pneumonia; Legionella pneumophila serogroup 12; Sequence-based typing