title: Anti-ulcer and wound healing activities of Sida corymbosa in rats.
abstract: BACKGROUND
  There are strong beliefs in the efficacy of traditional medical systems worldwide. Many herbs have been acclaimed to possess antiulcer effects and could be unexplored sources of new lead compounds. Sida corymbosa R. E. Fries (Malvaceae) is used in Northern Nigeria to treat ulcers and wounds. This work aimed to investigate the usefulness of Sida corymbosa in treatments of stomach ulcers and wounds in traditional medicine.
  
  
  METHODS
  Effect of the aqueous extract was determined on gastric ulceration, rate of wound healing and inflammation using ethanol-induced and diclofenac-induced ulceration, wound excision model and albumin-induced inflammation respectively in rats.
  
  
  RESULTS
  The study demonstrated the anti-ulcer activity of Sida corymbosa as the extract (250, 500 and 1000 mg/kg) showed a dose-dependent, significant (P<0.05) reduction of ulcer indices against gastric ulcers induced by both ethanol and diclofenac. Topical application of a formulation prepared with the extract of Sida corymbosa on surgically created incisions produced an increase in the rate of healing of the wounds. The extract of Sida corymbosa exhibited a significant (P < 0.05), dose-related decrease in inflammation induced by fresh egg albumin. This study showed that Sida corymbosa has constituents with the ability to reduce the severity of haemorrhagic gastric lesions, promote wound healing and reduce inflammation. These actions may be attributed to any one of the active constituents or as a result of synergistic effects of these phytoconstituents.
  
  
  CONCLUSIONS
  This study validates the use of the plant in traditional medicine for the treatment of stomach ulcers and wounds.
authors.affiliation: Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu, Abuja.
authors.forename: Lucy Binda
authors.initials: LB
authors.lastname: John-Africa
authors.affiliation: Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu, Abuja.
authors.forename: Tijani Adeniyi
authors.initials: TA
authors.lastname: Yahaya
authors.affiliation: Department of Raw Materials Research and Pharmaceutical Technology, National Institute for Pharmaceutical Research and Development, Idu, Abuja.
authors.forename: Christianah Yetunde
authors.initials: CY
authors.lastname: Isimi
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004008:Diclofenac; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D019660:Malvaceae; D016488:Medicine, African Traditional; D010047:Ovalbumin; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D004008:Diclofenac; D000431:Ethanol; D010047:Ovalbumin
keywords: Anti-Ulcer; Sida corymbosa; Wound Healing