title: TISSUE ENGINEERING PERFUSABLE CANCER MODELS.
abstract: The effect of fluid flow on cancer progression is currently not well understood, highlighting the need for perfused tumor models to close this gap in knowledge. Enabling biological processes at the cellular level to be modeled with high spatiotemporal control, microfluidic tumor models have demonstrated applicability as platforms to study cell-cell interactions, effect of interstitial flow on tumor migration and the role of vascular barrier function. To account for the multi-scale nature of cancer growth and invasion, macroscale models are also necessary. The consideration of fluid dynamics within tumor models at both the micro- and macroscopic levels may greatly improve our ability to more fully mimic the tumor microenvironment.
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX 77030.
authors.forename: E L
authors.initials: EL
authors.lastname: Fong
authors.affiliation: Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005.
authors.forename: M
authors.initials: M
authors.lastname: Santoro
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX 77030 ; Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251.
authors.forename: M C
authors.initials: MC
authors.lastname: Farach-Carson
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX 77030.
authors.forename: F K
authors.initials: FK
authors.lastname: Kasper
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX 77030 ; Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005.
authors.forename: A G
authors.initials: AG
authors.lastname: Mikos
keywords: Cancer; Fluid flow; Perfusion; Tissue engineering; Tumor models