title: [Effect of overweight on the outcome of assisted reproductive technology in infertile women].
abstract: OBJECTIVE
  Obesity and overweight negatively affect the ability of women to conceive naturally, contributes to the increased incidence of obstetric complications during pregnancy and affect the outcome of assisted reproduction techniques (ART). The aim of our study was to compare the results of treatment of infertilityin a group of infertile women undergoing ART, depending on the values of BMI and changes in levels of selected hormones and markers of oxidative stress in follicular fluid.
  
  
  METHODS
  Retrospective comparative study.
  
  
  METHODS
  Faculty of Medicine in Pilsen, Charles University in Prague; Institute of Reproductive Medicine and Endocrinology, IVF Centers - Prof. Zech, Plzeň.
  
  
  METHODS
  The studied group consisted of 44 women (mean age of 31.9 years, SD = 4.35) treated for infertility at the Institute of Reproductive Medicine and Endocrinology - IVF Centers Prof. Zech. Women were divided into 2 groups according to BMI (37 women had normal BMI, 7 women were overweight). Prolactin, free T3 and T4 hormone, homocysteine, malondialdehyde, glutathione peroxidase, total antioxidant capacity and total protein were analyzed in the follicular fluid both groups. Only blood free samples were studied after pooling of all FF samples of each patient.
  
  
  RESULTS
  We observed significantly lower levels of glutathion peroxidase in the group of overweight women(p = 0.0044). The pregnancy success rate with women with normal BMI and overweight women did not differ significantly from each other (p = 0.4430).
  
  
  CONCLUSIONS
  Our study did not confirm the negative effect of obesity on the results of treatment of infertility, specifical-ly pregnancy rate in a group of infertile women undergoing treatment with assisted reproduction techniques.
authors.forename: M
authors.initials: M
authors.lastname: Čedíková
authors.forename: V
authors.initials: V
authors.lastname: Babuška
authors.forename: P
authors.initials: P
authors.lastname: Lhotská
authors.forename: P
authors.initials: P
authors.lastname: Lošan
authors.forename: N H
authors.initials: NH
authors.lastname: Zech
authors.forename: M
authors.initials: M
authors.lastname: Králíčková
authors.forename: Z
authors.initials: Z
authors.lastname: Novotný
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000628:therapy*; D050177:Overweight / Q000150:complications*; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends*; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies