title: The control of blood platelets by cAMP signalling.
abstract: Blood platelet activation must be tightly regulated to ensure a balance between haemostasis and thrombosis. The cAMP signalling pathway is the most powerful endogenous regulator of blood platelet activation. PKA (protein kinase A), the foremost effector of cAMP signalling in platelets, phosphorylates a number of proteins that are thought to modulate multiple aspects of platelet activation. In the present mini-review, we outline our current understanding of cAMP-mediated platelet inhibition and discuss some of the issues that require clarification.
authors.affiliation: *Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull, Cottingham Road, Hull HU6 7RX, U.K.
authors.forename: Zaher
authors.initials: Z
authors.lastname: Raslan
authors.affiliation: *Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull, Cottingham Road, Hull HU6 7RX, U.K.
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Naseem
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation; D015539:Platelet Activation / Q000502:physiology; D015398:Signal Transduction
chemical_list: D000242:Cyclic AMP