title: Allelic variants of PRNP in 16 Chinese local sheep breeds.
abstract: Here, polymorphisms of the ovine prion protein gene were analyzed in 486 Chinese sheep from 16 main local breeds. Polymorphisms R or H at codons 154 and four polymorphisms at codon 171 encoding Q, R, H, or K were identified. The A/V polymorphism at codon 136 was not observed, and all sheep were homozygous for A at this position. In addition, ten polymorphisms at codons 21, 101, 112, 127, 138, 141, 143, 146, 153 and 189 were detected. The predominant Q allele occurred at codon 171, with a high frequency of 88.68 %, implying a risk of scrapie in China.
authors.affiliation: China Animal Health and Epidemiology Center, No. 369, Nanjing Road, Qingdao, 266032, Shandong, People's Republic of China.
authors.forename: Zouran
authors.initials: Z
authors.lastname: Lan
authors.forename: Jinming
authors.initials: J
authors.lastname: Li
authors.forename: Chengyou
authors.initials: C
authors.lastname: Sun
authors.forename: Yutian
authors.initials: Y
authors.lastname: Liu
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Zhao
authors.forename: Tianying
authors.initials: T
authors.lastname: Chi
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Yu
authors.forename: Fangfang
authors.initials: F
authors.lastname: Song
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000483:Alleles; D000818:Animals; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D011110:Polymorphism, Genetic; D011328:Prions / Q000235:genetics* / Q000378:metabolism; D012608:Scrapie / Q000235:genetics* / Q000378:metabolism; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics* / Q000378:metabolism
chemical_list: D011328:Prions