title: Preparation of lutein-loaded particles for improving solubility and stability by Polyvinylpyrrolidone (PVP) as an emulsion-stabilizer.
abstract: Lutein, a non-provitamin A carotenoid, possesses multiple valuable physiological functions. Unfortunately, its application is limited due to its poor water solubility and instability under adverse conditions. To expand the applied range of lutein, we developed lutein-loaded particles and characterized by differential scanning calorimetry, X-ray powder diffraction and Fourier transformed infrared spectroscopy and investigated the encapsulation efficiency, aqueous saturation solubility and stability. The results showed that the lutein-loaded particles possessed high encapsulation efficiency (93.8±0.35%) and good water solubility (158μg/ml). Compared with free lutein, the stability of the lutein-loaded particles against heat, light and oxygen was improved by 1.7 times, 3.3 times and 4.0 times, respectively. The results also indicated that lutein was embedded in PVP matrix in an amorphous state, and intermolecular hydrogen bonding was in existence between PVP, lutein and Tween 80, forming the main force assembling the lutein-loaded particles.
authors.affiliation: College of Pharmacy Engineering, Shenyang Pharmaceutical University, Wenhua Road, No.103, Shenyang 110016, PR China.
authors.forename: Changdong
authors.initials: C
authors.lastname: Zhao
authors.affiliation: College of Pharmacy Engineering, Shenyang Pharmaceutical University, Wenhua Road, No.103, Shenyang 110016, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Cheng
authors.affiliation: College of Pharmacy Engineering, Shenyang Pharmaceutical University, Wenhua Road, No.103, Shenyang 110016, PR China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Jiang
authors.affiliation: College of Pharmacy Engineering, Shenyang Pharmaceutical University, Wenhua Road, No.103, Shenyang 110016, PR China.
authors.forename: Yijing
authors.initials: Y
authors.lastname: Yao
authors.affiliation: College of Pharmacy Engineering, Shenyang Pharmaceutical University, Wenhua Road, No.103, Shenyang 110016, PR China. Electronic address: hj-8080@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Han
mesh_terms: D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry; D014975:Lutein / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D004655:Emulsions; D011205:Povidone; D014975:Lutein
keywords: Intermolecular hydrogen bonding; Lutein; PVP; Tween 80