title: Complete pathological response to neoadjuvant pemetrexed/cisplatin in combination with regional hyperthermia in a patient with sarcomatoid peritoneal mesothelioma.
abstract: Diffuse malignant peritoneal mesothelioma (DMPM) is a rare disease. Although most patients eligible for surgery undergo cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy, the role of perioperative systemic chemotherapy still remains undefined. Here we report the case of a 52-year-old female patient with advanced sarcomatoid DMPM. After five cycles of systemic pemetrexed and cisplatin, along with two cycles of regional hyperthermia, tumor resection with histomorphological examination showed a complete pathological response. We therefore conclude that there is a subgroup of DMPM patients that might benefit from systemic neoadjuvant chemotherapy with pemetrexed and cisplatin.
authors.affiliation: Departments of aInternal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern bGeneral, Visceral, Transplantation, Vascular and Thoracic Surgery, Klinikum Grosshadern cClinical Radiology, Klinikum Grosshadern dDepartment of Pathology, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Kruger
authors.forename: Martin K
authors.initials: MK
authors.lastname: Angele
authors.forename: Simone
authors.initials: S
authors.lastname: Reu
authors.forename: Karl
authors.initials: K
authors.lastname: Sotlar
authors.forename: Anno
authors.initials: A
authors.lastname: Graser
authors.forename: Michael
authors.initials: M
authors.lastname: Haas
authors.forename: Markus
authors.initials: M
authors.lastname: Albertsmeier
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Stemmler
authors.forename: Volker
authors.initials: V
authors.lastname: Heinemann
authors.forename: Lars H
authors.initials: LH
authors.lastname: Lindner
authors.forename: Stefan
authors.initials: S
authors.lastname: Boeck
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005971:Glutamates / Q000008:administration & dosage; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D006979:Hyperthermia, Induced; D008654:Mesothelioma / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D000068437:Pemetrexed; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000628:therapy*; D012509:Sarcoma / Q000473:pathology / Q000628:therapy*
chemical_list: D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine; D002945:Cisplatin