title: Identification of Xq22.1-23 as a region linked with hereditary recurrent spontaneous abortion in a family.
abstract: BACKGROUND
  Recurrent spontaneous abortion (RSA) is one of the most common health complications with a strong genetic component. Several genetic disorders were identified as etiological factors of hereditary X linked RSA. However, more genetic factors remain to be identified.
  
  
  OBJECTIVE
  In this study we performed linkage analysis on a large X linked RSA pedigree to find a novel susceptibility locus for RSA.
  
  
  METHODS
  A linkage scan using 11 microsatellites was performed in 27 members of a large pedigree of hereditary X-linked RSA. Two point parametric Linkage was performed using Superlink v 1.6 program.
  
  
  RESULTS
  Evidence of linkage was observed to markers at Xq23, DXS7133 and at Xq22.1 DXS101, with LOD score of 3.12 and 1.60, respectively.
  
  
  CONCLUSIONS
  Identified locus in this study may carry a responsible gene in RSA. Narrowing down of this region may leads to identification of this gene. This article extracted from M.Sc. thesis. (Sahar Shekouhi).
authors.affiliation: Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Sahar
authors.initials: S
authors.lastname: Shekouhi
authors.affiliation: Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Baghbani
authors.affiliation: Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hasanzadeh Nazar-Abadi
authors.affiliation: Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Tayebeh
authors.initials: T
authors.lastname: Hamzehloie
authors.affiliation: Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Abbaszadegan
authors.affiliation: Department of Gynecology, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Nafiseh
authors.initials: N
authors.lastname: Saghafi
authors.affiliation: Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Raoofian
authors.affiliation: Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Zavar Reza
authors.affiliation: Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Shahab
authors.initials: S
authors.lastname: Ahmadzadeh
authors.affiliation: Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Mohammad Amin
authors.initials: MA
authors.lastname: Tabatabaiefar
authors.affiliation: Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Mojarrad
keywords: Linkage; Recurrentspontaneousabortion; X-linked