title: The child with difficult to control Congenital Adrenal Hyperplasia: is there a place for continuous subcutaneous hydrocortisone therapy.
abstract: The treatment of congenital adrenal hyperplasia requires administration of glucocorticoid and mineralocorticoid to replace the deficit resulting from the enzymatic block. During puberty, cortisol metabolism changes with an increase in clearance, which may lead to unstable control. This may require an increase in dosing frequency, and if this proves problematic, continuous subcutaneous hydrocortisone delivery using insulin pump technology can be valuable. The potential indications for such therapy along with some practical considerations are detailed in this Clinical Question report.
authors.affiliation: Developmental Endocrinology Research Group, UCL Institute of Child Health, London, UK.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Hindmarsh
mesh_terms: D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000188:drug therapy*; D002940:Circadian Rhythm / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use*; D055104:Infusions, Subcutaneous; D008297:Male; D016896:Treatment Outcome
chemical_list: D006854:Hydrocortisone