title: Ligand control of g protein-coupled receptor activity: new insights.
abstract: In this issue of Chemistry & Biology, Srinivasan and colleagues describe their study of ligand-protein interactions in visual pigments. Comparing the more stable isomeric ligand 9-cis retinal to the physiologically occurring 11-cis retinal, they report differences in ligand specificity and opsin conformational stability not previously described for bleached rhodopsin.
authors.affiliation: Medical University of South Carolina, Charleston, SC 29425 USA. Electronic address: crouchrk@musc.edu.
authors.forename: Rosalie K
authors.initials: RK
authors.lastname: Crouch
authors.affiliation: Medical University of South Carolina, Charleston, SC 29425 USA.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kono
mesh_terms: D000818:Animals; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D012168:Retinal Pigments / Q000378:metabolism*; D012172:Retinaldehyde / Q000378:metabolism*; D012243:Rhodopsin / Q000378:metabolism*
chemical_list: D043562:Receptors, G-Protein-Coupled; D012168:Retinal Pigments; D012243:Rhodopsin; D012172:Retinaldehyde