title: Copper-catalyzed α-methylenation of benzylpyridines using dimethylacetamide as one-carbon source.
abstract: The direct α-methylenation of benzylpyridines was achieved using N,N-dimethylacetamide (DMA) as a one-carbon source under copper catalysis. An intermediary species was detected at an early stage, and a possible mechanism was proposed. Additionally, α-oxygenation and dimerization of benzylpyridines could also be performed efficiently.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Itoh
authors.forename: Koji
authors.initials: K
authors.lastname: Hirano
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Satoh
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miura
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D001593:Benzyl Compounds / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000081:Acetamides; D001593:Benzyl Compounds; D011725:Pyridines; D002244:Carbon; D003300:Copper; C074928:2-benzylpyridine; C013959:dimethylacetamide