title: Antidepressant-like effects of auraptenol in mice.
abstract: Depression is a major psychiatric disorder affecting nearly 21% of the world population and imposes a substantial health burden on society. Current available antidepressants are not adequate to meet the clinical needs. Here we report that auraptenol, an active component of the traditional Chinese medicine, angelicae dahuricae radix, had antidepressant-like effects in mice models of depression. In mouse forced swimming test and tail suspension test, two validated models of depression, auraptenol dose-dependently decreased the immobility duration within the dose range of 0.05-0.4 mg/kg. In addition, the antidepressant-like effects of auraptenol was significantly averted by a selective serotonin 5-HT1A receptor antagonist WAY100635 (1 mg/kg). These doses that affected the immobile response did not affect locomotor activity. In summary, this study for the first time identified an active component from the herbal medicine angelicae dahuricae radix that possesses robust antidepressant-like efficacy in mice. These data support further exploration for the possibility of developing auraptenol as a novel antidepressant agent in the treatment of major depression disorders.
authors.affiliation: 1] The Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000 China [2] Institute of Neuroscience; Soochow University; Suzhou, Jiangsu, 215123 China [3] Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001 China.
authors.forename: Xiaosu
authors.initials: X
authors.lastname: Gu
authors.affiliation: The Department of Neurology, The First People's Hospital of Nantong, Nantong, Jiangsu, 226001 China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Neuropharmacology, Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu, 226001 China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Wu
authors.affiliation: 1] The Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000 China [2] Institute of Neuroscience; Soochow University; Suzhou, Jiangsu, 215123 China.
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.affiliation: 1] The Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000 China [2] Institute of Neuroscience; Soochow University; Suzhou, Jiangsu, 215123 China.
authors.forename: Cai-Yi
authors.initials: CY
authors.lastname: Zhang
authors.affiliation: 1] The Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000 China [2] Institute of Neuroscience; Soochow University; Suzhou, Jiangsu, 215123 China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Du
authors.affiliation: Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001 China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001 China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001 China.
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Shi
authors.affiliation: 1] The Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000 China [2] Institute of Neuroscience; Soochow University; Suzhou, Jiangsu, 215123 China.
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001 China.
authors.forename: Kaifu
authors.initials: K
authors.lastname: Ke
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000818:Animals; D000928:Antidepressive Agents / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D003374:Coumarins / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D008517:Phytotherapy; D010879:Piperazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D044263:Receptors, Serotonin, 5-HT1 / Q000378:metabolism; D058829:Serotonin 5-HT1 Receptor Antagonists / Q000494:pharmacology; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D010879:Piperazines; D011725:Pyridines; D044263:Receptors, Serotonin, 5-HT1; D058829:Serotonin 5-HT1 Receptor Antagonists; C000591095:auraptenol; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide