title: Mediastinal microdialysis in the diagnosis of early anastomotic leakage after resection for cancer of the esophagus and gastroesophageal junction.
abstract: BACKGROUND
  Anastomotic leakage (AL) after gastroesophageal resection for cancer is a serious complication. The aim was to evaluate mediastinal microdialysis in the detection of AL before clinical symptoms.
  
  
  METHODS
  Sixty patients were included. Samples were collected every 4 hours in the 1st 8 postoperative days and analyzed for several metabolites.
  
  
  RESULTS
  Forty-four patients had an uncomplicated postoperative recovery, 7 developed anastomotic-related complications, and 5 developed major nonanastomotic-related complications. Six patients were excluded (early catheter malfunction and reoperation). Logistic regression model on several metabolites demonstrated a 100% sensitivity, specificity, and positive and negative predictive values regarding the diagnosis of anastomotic complications within postoperative day 7. However, as independent markers, none of the measured metabolites were able to predict AL.
  
  
  CONCLUSIONS
  The diagnosis of anastomotic-related complications before clinical symptoms seemed possible by mediastinal microdialysis, but the diagnosis should be based on an interpretation of several metabolic events.
authors.affiliation: Department of Surgery, Odense University Hospital, DK-5000 Odense C, Denmark. Electronic address: markep01@gmail.com.
authors.forename: Mark
authors.initials: M
authors.lastname: Ellebæk
authors.affiliation: Department of Surgery, Odense University Hospital, DK-5000 Odense C, Denmark.
authors.forename: Niels
authors.initials: N
authors.lastname: Qvist
authors.affiliation: Department of Surgery, Odense University Hospital, DK-5000 Odense C, Denmark.
authors.forename: Claus
authors.initials: C
authors.lastname: Fristrup
authors.affiliation: Department of Surgery, Odense University Hospital, DK-5000 Odense C, Denmark.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Mortensen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D057868:Anastomotic Leak / Q000175:diagnosis*; D002277:Carcinoma / Q000601:surgery*; D042241:Early Diagnosis; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy; D004943:Esophagogastric Junction / Q000601:surgery*; D004947:Esophagus / Q000601:surgery; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008482:Mediastinum; D017551:Microdialysis / Q000379:methods*; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods*; D011446:Prospective Studies; D012680:Sensitivity and Specificity
keywords: Anastomotic leakage; Esophageal cancer; Lactate/glucose ratio; Lactate/pyruvate ratio; Mediastinal microdialysis