title: [Biomarkers for the prognosis of severe dengue].
abstract: BACKGROUND
  There are very few strategies for the early detection of the patients who might develop the severe form of the illness.
  
  
  OBJECTIVE
  To evaluate the utility of serum levels of some immune response mediators as early biomarkers for the severe dengue prognosis during the early phase of the illness.
  
  
  METHODS
  Using a case-control design nested in a multicenter cohort from the AEDES network (a Colombian multicenter study), we compared TNF a, ST2, TRAIL and IDO levels in samples which were obtained during the early phase of the illness.
  
  
  RESULTS
  ST2, TRAIL and TNF a levels were higher in severe dengue patients compared with uncomplicated patients (p<0.0001), as follows: OR=24.8, CI95%= 6.1- 98.0; OR=18.0, CI95%= 4.6-69.1; OR=NC, CI95%= NC, respectively. We did not find statistically significant differences between IDO levels in severe dengue and uncomplicated dengue (p=1.000, OR=1.0, CI95%= 0.2-6.1).
  
  
  CONCLUSIONS
  In the early phase of the dengue infection (96 hours), ST2, TRAIL and TNF a quantifications could contribute to the prediction of complications of the illness.
authors.affiliation: Centro de Investigaciones Epidemiológicas, Universidad Industrial de Santander, Bucaramanga, Colombia.
authors.forename: Luis Ángel
authors.initials: LÁ
authors.lastname: Villar
authors.affiliation: Grupo de Epidemiología Clínica, Centro de Investigaciones Epidemiológicas, Universidad Industrial de Santander.
authors.forename: Rosa Margarita
authors.initials: RM
authors.lastname: Gélvez
authors.affiliation: Red AEDES: Abordando Áreas Endémicas del Dengue para el Estudio de su Severidad (sic.), Colombia.
authors.forename: Jairo Antonio
authors.initials: JA
authors.lastname: Rodríguez
authors.affiliation: Grupo de Parasitología y Medicina Tropical, Universidad Surcolombiana, Neiva, Colombia.
authors.forename: Doris
authors.initials: D
authors.lastname: Salgado
authors.affiliation: Grupo de Virus Emergentes y Enfermedad (VIREM), Universidad del Valle, Cali, Colombia.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Parra
authors.affiliation: Grupo de Epidemiología y Salud Poblacional, Escuela de Salud Pública, Facultad de Salud, Universidad del Valle.
authors.forename: Lyda
authors.initials: L
authors.lastname: Osorio
authors.affiliation: Massachusetts Institute of Technology, Cambridge, USA.
authors.forename: Irene
authors.initials: I
authors.lastname: Bosch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000097:blood; D000072179:Interleukin-1 Receptor-Like 1 Protein; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000097:blood*; D019595:Severe Dengue / Q000097:blood*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; C576710:IDO1 protein, human; C576711:IDO2 protein, human; C079241:IL1RL1 protein, human; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D000072179:Interleukin-1 Receptor-Like 1 Protein; D011956:Receptors, Cell Surface; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha