title: DnaA dynamics could be linked with fitness cost in bacteria.
abstract: Fitness cost is the measure of the metabolic burden of unneeded gene expression. It is defined as the lag in bacterial cells growth harboring unneeded genes relative to unburdened cells. Separate cells can concurrently adapt to the burden, demonstrating a decrease in or even a disappearance of the lag. The precise mechanisms of this adaptation are not clearly understood. One possibility is that an increased amount of free ribosomes "absorb" the unnecessary burden. In this work, the mechanism by which an increased concentration of ribosomes could result in faster growth and mask the unneeded gene expression burden is discussed. The initiation time of chromosome replication by the initiator protein DnaA, for which the accumulation speed depends on the ribosomes amount, is taken into account.
authors.affiliation: Institute of Engineering Physics and Radio Electronics, Siberian Federal University, 79, Svobodny Prospect, Krasnoyarsk, 660041, Russia, AShuvaev@sfu-kras.ru.
authors.forename: Andrey
authors.initials: A
authors.lastname: Shuvaev
mesh_terms: D001419:Bacteria / Q000166:cytology / Q000235:genetics* / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D056084:Genetic Fitness; D012270:Ribosomes / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C066312:DnaA protein, Bacteria