title: Participation of interleukin 17A in neuroimmune interactions.
abstract: Inflammation involving the helper T cell 17 (Th17) subset of lymphocytes has been implicated in a number of diseases that affect the nervous system. As the canonical cytokine of Th17 cells, interleukin 17A (IL-17A) is thought to contribute to these neuroimmune interactions. The main receptor for IL-17A is expressed in many neural tissues. IL-17A has direct effects on neurons but can also impact neural function via signaling to satellite cells and immune cells. In the central nervous system, IL-17A has been associated with neuropathology in multiple sclerosis, epilepsy syndromes and ischemic brain injury. Effects of IL-17A at the level of dorsal root ganglia and the spinal cord may contribute to enhanced nociception during neuropathic and inflammatory pain. Finally, IL-17A plays a role in sympathetic axon growth and regeneration of damaged axons that innervate the cornea. Given the widespread effects of IL-17A on neural tissues, it will be important to determine whether selectively mitigating the damaging effects of this cytokine while augmenting its beneficial effects is a possible strategy to treat inflammatory damage to the nervous system.
authors.affiliation: Department of Biomedical and Molecular Sciences, Gastrointestinal Diseases Research Unit and Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
authors.forename: Derek M
authors.initials: DM
authors.lastname: Moynes
authors.affiliation: Department of Biomedical and Molecular Sciences, Gastrointestinal Diseases Research Unit and Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada; Department of Medicine, Gastrointestinal Diseases Research Unit and Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Vanner
authors.affiliation: Department of Biomedical and Molecular Sciences, Gastrointestinal Diseases Research Unit and Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada; Department of Medicine, Gastrointestinal Diseases Research Unit and Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada. Electronic address: Lomaxa@queensu.ca.
authors.forename: Alan E
authors.initials: AE
authors.lastname: Lomax
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000503:physiopathology; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D002490:Central Nervous System / Q000276:immunology / Q000502:physiology; D004195:Disease Models, Animal; D004827:Epilepsy / Q000276:immunology / Q000503:physiopathology; D005727:Ganglia, Spinal / Q000166:cytology / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D020381:Interleukin-17 / Q000502:physiology*; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D051379:Mice; D009410:Nerve Degeneration / Q000276:immunology / Q000378:metabolism; D009437:Neuralgia / Q000276:immunology / Q000503:physiopathology; D009457:Neuroglia / Q000378:metabolism; D015213:Neuroimmunomodulation / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D058748:Pain Perception / Q000502:physiology; D051381:Rats; D053722:Receptors, Interleukin-17 / Q000502:physiology; D058504:Th17 Cells / Q000276:immunology*
chemical_list: C508717:IL17A protein, human; C098680:Il17a protein, mouse; C515934:Il17a protein, rat; D020381:Interleukin-17; D053722:Receptors, Interleukin-17
keywords: Autoimmunity; Electrophysiology; Neurite sprouting; Neuropathology; Plasticity