title: Correlation between serum lipids and 1-hour postload plasma glucose levels in normoglycemic individuals.
abstract: BACKGROUND
  One-hour plasma glucose (1-h PG) level of ≥ 155 mg/dL during an oral glucose tolerance test (OGTT) predicts the development of type 2 diabetes mellitus among individuals with normal glucose tolerance (NGT). In addition, high triglyceride (TG) and low high-density lipoprotein-cholesterol (HDL-C) levels are risks factors for development of diabetes mellitus in the future.
  
  
  OBJECTIVE
  To examine the association between 1-h PG levels and serum lipid profiles in individuals with NGT.
  
  
  METHODS
  We enrolled 736 individuals with NGT who underwent a 75-g OGTT. They were divided into 2 groups, those with 1-h PG levels < 155 mg/dL (n = 543) and those with 1-h PG levels ≥ 155 mg/dL (n = 193). Multivariate linear regression analyses were performed to assess correlations between 1-h PG levels and lipid profiles.
  
  
  RESULTS
  The multiple linear regression analyses showed that 1-h PG levels negatively correlated with HDL-C in individuals with NGT who had 1-h PG levels ≥ 155 mg/dL as well as those with 1-h PG levels < 155 mg/dL (β = -0.137, P = .001 and β = -0.214, P = .003, respectively). In addition, 1-h PG levels positively correlated with log-transformed TG/HDL-C ratio in both groups (β = 0.098, P = .032 and β = 0.152, P = .035, respectively). Moreover, even after adjusting for confounding parameters, TG was higher and HDL-C was lower in individuals with NGT who had 1-h PG levels ≥ 155 mg/dL compared with those who had 1-h PG levels < 155 mg/dL.
  
  
  CONCLUSIONS
  HDL-C levels and TG/HDL-C ratios closely correlate with 1-h PG levels in individuals with NGT.
authors.affiliation: Department of Internal Medicine, Iida Municipal Hospital, Nagano, Japan; Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan. Electronic address: masanori19810813@yahoo.co.jp.
authors.forename: Masanori
authors.initials: M
authors.lastname: Shimodaira
authors.affiliation: Department of Internal Medicine, Iida Municipal Hospital, Nagano, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Niwa
authors.affiliation: Department of Internal Medicine, Iida Municipal Hospital, Nagano, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Nakajima
authors.affiliation: Department of Internal Medicine, Iida Municipal Hospital, Nagano, Japan.
authors.forename: Mutsuhiro
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Department of Internal Medicine, Iida Municipal Hospital, Nagano, Japan.
authors.forename: Norinao
authors.initials: N
authors.lastname: Hanyu
authors.affiliation: Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakayama
mesh_terms: D000328:Adult; D001786:Blood Glucose; D008076:Cholesterol, HDL / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides; D005947:Glucose
keywords: Diabetes; HDL- cholesterol; Lipids; One-hour plasma glucose level; Oral glucose tolerance test; Triglyceride