title: Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells.
abstract: Data derived from massive cloning and traditional sequencing methods have revealed that long non-coding RNAs (lncRNA) play important roles in the development and progression of cancer. Although many studies suggest that the lncRNAs have different cellular functions, many of them are not yet to be identified and characterized for the mechanism of their functions. To address this question, we assay the expression level of lncRNAs-Loc554202 in breast cancer tissues and find that Loc554202 is significantly increased compared with normal control, and associated with advanced pathologic stage and tumor size. Moreover, knockdown of Loc554202 decreased breast cancer cell proliferation, induced apoptosis and inhibits migration/invasion in vitro and impeded tumorigenesis in vivo. These data suggest an important role of Loc554202 in breast tumorigenesis.
authors.affiliation: Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: 1138303166@qq.com.
authors.forename: Yongguo
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Cancer Hospital of Jiangsu Province, Nanjing, Jiangsu, PR China. Electronic address: jianwei2010077@163.com.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Oncology, Taizhou People' Hospital, Taizhou, Jiangsu, PR China. Electronic address: 2310848@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: 843039795@qq.com.
authors.forename: Xueming
authors.initials: X
authors.lastname: Tan
authors.affiliation: Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: 2825636@qq.com.
authors.forename: Ye
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: 9111165@qq.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: 1815857@qq.com.
authors.forename: Yun
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: 2376737@qq.com.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: wkmys@sohu.com.
authors.forename: Keming
authors.initials: K
authors.lastname: Wang
mesh_terms: D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
keywords: Breast cancer; Loc554202; lncRNA