title: A new dolabellane diterpenoid and a sesquilignan from Aglaia odorata var. microphyllina.
abstract: One new diterpenoid, 11alpha,12betaH-dolabella-4,8(17)-dien-3alpha,7beta,18-triol (1) and one new sesquilignan, 9-methoxy-7',8'-cis-7",8"-cis-buddlenol B (2), together with three known compounds, (+)-diasyringaresinol (3), N-methyl-5- hydroxy-delta3-pyrrolin-2-one (4) and marmin (5), have been isolated from Aglaia odorata var. microphyllina. Their structures were determined using 1D and 2D NMR spectroscopy. Compound 1 exhibited cytotoxic activity against the K562 cell line with an IC50 value of 12.5 microg/mL.
authors.forename: Shuai
authors.initials: S
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Shou-Bai
authors.initials: SB
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Zhi-Kai
authors.initials: ZK
authors.lastname: Guo
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Zeng
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Dong
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D031602:Aglaia / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: C587756:9-methoxy-7',8'-cis-7'',8''-cis-buddlenol B; D004224:Diterpenes; C115566:dolabellane