title: miR-223: An inflammatory oncomiR enters the cardiovascular field.
abstract: MicroRNAs (miRNAs) are small, noncoding RNAs of 18-22 nucleotides in length that regulate post-transcriptional expression by base-pairing with target mRNAs. It is now clearly established that miRNAs are involved in most of the cell's physiopathological processes (including carcinogenesis and metabolic disorders). This review focuses on miR-223, which was first described as a modulator of hematopoietic lineage differentiation. We outline the role of miR-223 deregulation in several types of cancers and highlight its inclusion in a newly identified and fast-growing family of miRNAs called oncomiRs. We then look at miR-223's emerging role in inflammatory and metabolic disorders, with a particular focus on muscle diseases, type II diabetes, atherosclerosis and vascular calcification. miR-223 is one of the growing number of RNA biomarkers of various human metabolic diseases and is thus of special interest to both researchers and clinicians in the cardiovascular field.
authors.affiliation: INSERM U1088, University of Picardie Jules Verne, 1 Rue des Louvels, F-80037 Amiens, France.
authors.forename: Fatiha
authors.initials: F
authors.lastname: Taïbi
authors.affiliation: INSERM U1088, University of Picardie Jules Verne, 1 Rue des Louvels, F-80037 Amiens, France; Université Paris 13, UFR SMBH, 74 rue Marcel Cachin, F-93017 Bobigny, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Metzinger-Le Meuth
authors.affiliation: INSERM U1088, University of Picardie Jules Verne, 1 Rue des Louvels, F-80037 Amiens, France; Division of Nephrology, Ambroise Paré Hospital, Paris UVSQ University, 09 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France.
authors.forename: Ziad A
authors.initials: ZA
authors.lastname: Massy
authors.affiliation: INSERM U1088, University of Picardie Jules Verne, 1 Rue des Louvels, F-80037 Amiens, France; Centre De Biologie Humaine (CBH), Amiens University Hospital, Avenue René Laennec, F-80054 Amiens, France. Electronic address: laurent.metzinger@u-picardie.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Metzinger
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000473:pathology; D002454:Cell Differentiation / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology
chemical_list: D035683:MicroRNAs; C525067:MIR223, human; C544877:MIRN223 microRNA, mouse
keywords: Cancer; Hematopoiesis; MicroRNA; Muscle; Vascular disease; miR-223