title: Is a positron emission tomography-computed tomography scan useful in the staging of thymic epithelial neoplasms?
abstract: A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed concerned the employment of 18-fluorine fluorodeoxyglucose positron emission tomography/computed tomography (PET-CT) in the preoperative evaluation of thymic epithelial neoplasms (TENs). We reviewed its role as a predictor of Masaoka stage and histology (according to the WHO). In clinical practice, stage is considered the most important determinant in the therapeutic approach. A total of 265 papers were found as a result of the reported search, of which 14 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. All the studies are retrospective analyses. Patient numbers varied from 13 to 58. Our research showed that PET-CT could clearly add information about the histology of the tumour. Thymic carcinoma constantly showed a higher standard uptake value (SUVmax) than thymomas. Furthermore, in one retrospective study of 36 patients, when using a derived PET indicator, the T/M ratio (ratio between SUVmax of the tumour and SUVmax of mediastinum, as conventionally measured at the level of the aortic arc), PET-CT could also differentiate between low- and high-risk thymomas (low risk vs high risk P = 0.01). In another study, a cut-off value of T/M ratio of 2.75 was identified between low- and high-risk TENs. The role of PET-CT in prediction of stage is harder to recognize. In one study, there was a statistically significant correlation between SUVmax, T/M ratio and Masaoka stage (P = 0.781 and 0.718, respectively). When analysing the data from the three larger series on this topic (58, 51 and 47 patients, the latter group selected in a multicentre study), only one study identified a correlation between SUVmax and Masaoka stage (Spearman correlation coefficient 0.30, P = 0.0436), while the other two failed to identify a relationship between SUVmax and stage. In three retrospective studies, PET-CT identified otherwise undetected distant metastases, thereby modifying the clinical approach. Actually, when evaluating the correlation between stage and PET-CT indicators (in particular SUVmax), results are controversial and would need further speculation.
authors.affiliation: Thoracic Surgery Unit, S. Croce e Carle Hospital, Cuneo, Italy vitimassa@hotmail.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Viti
authors.affiliation: Thoracic Surgery Unit, Sacred Heart Hospital, Negrar, Verona, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Terzi
authors.affiliation: Nuclear Medicine Service, S. Croce e Carle Hospital, Cuneo, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bianchi
authors.affiliation: Thoracic Surgery Unit, S. Croce e Carle Hospital, Cuneo, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Bertolaccini
mesh_terms: D019985:Benchmarking; D019317:Evidence-Based Medicine; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009367:Neoplasm Staging / Q000379:methods*; D009375:Neoplasms, Glandular and Epithelial / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D013953:Thymus Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: 18-Fluorine fluorodeoxyglucose positron emission tomography/computed tomography, staging; Review; Thymoma, positron emission tomography