title: Transcription and processing: multilayer controls of RNA biogenesis by the Hippo pathway.
abstract: The Hippo pathway plays a critical role in organ size control and tumorigenesis. YAP (and also its homologue TAZ) is a transcription co-activator that mediates the biological functions of the Hippo pathway. YAP activity is inhibited upon phosphorylation by the Lats kinases (reviewed in Yu & Guan, 2013). In a recent study in Cell, Mori et al (2014) uncover a new function of YAP in global microRNA (miRNA) biogenesis by the modulation of the Microprocessor machinery. The results also suggest that this novel YAP function may contribute to cell growth control and tumorigenesis.
authors.affiliation: Department of Pharmacology, Moores Cancer Center University of California, San Diego, La Jolla, CA, USA.
authors.forename: Fa-Xing
authors.initials: FX
authors.lastname: Yu
authors.forename: Kun-Liang
authors.initials: KL
authors.lastname: Guan
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism; D002450:Cell Communication / Q000235:genetics; D018797:Cell Cycle Proteins; D005786:Gene Expression Regulation / Q000235:genetics; D000090683:Hippo Signaling Pathway; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism; D009687:Nuclear Proteins / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D012313:RNA / Q000096:biosynthesis*; D012323:RNA Processing, Post-Transcriptional / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; D035683:MicroRNAs; D009687:Nuclear Proteins; D014157:Transcription Factors; C456659:YY1AP1 protein, human; D012313:RNA; D017346:Protein Serine-Threonine Kinases