title: Non-HDL cholesterol is an independent risk factor for aspirin resistance in obese patients with type 2 diabetes.
abstract: OBJECTIVE
  We evaluated the prevalence of aspirin resistance and predictive factors for aspirin resistance in Korean type 2 diabetes patients.
  
  
  RESULTS
  A total of 1045 type 2 diabetes patients from 11 hospitals who were taking aspirin (100 mg/day for ≥2 weeks) and no other antiplatelet agents were studied to evaluate aspirin resistance. Aspirin resistance was measured in aspirin reaction units using VerifyNow(®). Aspirin resistance was defined as ≥550 aspirin reaction units. Aspirin resistance was detected in 102 of the 1045 subjects (prevalence 9.8%). Aspirin resistance was associated with total cholesterol (P = 0.013), LDL-cholesterol (P = 0.028), and non-HDL cholesterol (P = 0.008) concentrations in univariate analysis. In multivariate logistic regression analysis, only non-HDL cholesterol was associated with aspirin resistance in obese (BMI >25 kg/m(2)) type 2 diabetes patients (adjusted odds ratio 3.55, 95% CI: 1.25-10.05, P = 0.017).
  
  
  CONCLUSIONS
  The prevalence of aspirin resistance in Korean type 2 diabetes patients is 9.8%. Non-HDL cholesterol is an independent risk factor for aspirin resistance, especially in obese type 2 diabetes patients.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, #108 Pyung-Dong, Jongno-Gu, Seoul, Republic of Korea.
authors.forename: Jong Dai
authors.initials: JD
authors.lastname: Kim
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, #108 Pyung-Dong, Jongno-Gu, Seoul, Republic of Korea.
authors.forename: Cheol-Young
authors.initials: CY
authors.lastname: Park
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Gangdong Kyunghee Hospital, Kyunghee University College of Medicine, #892 Dongnam-Ro, Gangdong-Gu, Seoul, Republic of Korea.
authors.forename: Kue Jeong
authors.initials: KJ
authors.lastname: Ahn
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul Saint Mary's Hospital, The Catholic University of Korea College of Medicine, #222 Banpodae-Ro, Seocho-Gu, Seoul, Republic of Korea.
authors.forename: Jae Hyoung
authors.initials: JH
authors.lastname: Cho
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, #148 Gurodong-Ro, Guro-Gu, Seoul, Republic of Korea.
authors.forename: Kyung Mook
authors.initials: KM
authors.lastname: Choi
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Pyungchon Sacred Heart Hospital, Hallym University College of Medicine, #896 Pyungchon-Dong, Dongan-Gu, Anyang, Gyunggi-Do, Republic of Korea.
authors.forename: Jun Goo
authors.initials: JG
authors.lastname: Kang
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Seoul Hospital, University of Sungkyunkwan College of Medicine, #50 Ilwon-Dong, Gangnam-Gu, Seoul, Republic of Korea.
authors.forename: Jae Hyeon
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Gil Hospital, Gacheon University College of Medicine, #774-2 Namdongdae-Ro, Namdong-Gu, Incheon, Republic of Korea.
authors.forename: Ki Young
authors.initials: KY
authors.lastname: Lee
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, #50 Yonsei-Ro, Seodaemun-Gu, Seoul, Republic of Korea.
authors.forename: Byung Wan
authors.initials: BW
authors.lastname: Lee
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon Soonchunhyang Hospital, Soonchunhyang University School of Medicine, #170 Jomaru-Ro, Wonmi-Gu, Bucheon, Gyunggi-Do, Republic of Korea.
authors.forename: Ji Oh
authors.initials: JO
authors.lastname: Mok
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Boramae Hospital, Seoul National University College of Medicine, #20 Boramae-Ro5, Dongjak-Gu, Seoul, Republic of Korea.
authors.forename: Min Kyong
authors.initials: MK
authors.lastname: Moon
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul Asan Hospital, Ulsan University, College of Medicine, #88 Olympic-Ro43, Songpa-Gu, Seoul, Republic of Korea.
authors.forename: Joong Yeol
authors.initials: JY
authors.lastname: Park
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, #108 Pyung-Dong, Jongno-Gu, Seoul, Republic of Korea. Electronic address: sungwoo0913.park@samsung.com.
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Park
mesh_terms: D044466:Asian People; D001241:Aspirin / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012307:Risk Factors
chemical_list: D010975:Platelet Aggregation Inhibitors; D002784:Cholesterol; D001241:Aspirin
keywords: Aspirin resistance; Atherogenic dyslipidemia; Diabetes; Non-HDL cholesterol