title: Difference in the emetic control among highly emetogenic chemotherapy regimens: Implementation for appropriate use of aprepitant.
abstract: Although antiemetic medication based on the emetogenicity of the cancer chemotherapy regimen is recommended, emetic control varies even among highly emetogenic chemotherapy (HEC). In the present study, we retrospectively investigated the rates of emetic control by a combination of granisetron, 5-HT3antagonist and dexamethasone in various HEC regimens, including 5 single-day chemotherapy regimens such as gemcitabine/cisplatin (GEM/CDDP), epirubicin/cyclophosphamide (EPI/CPA), pemetrexed or vinorelbine/cisplatin (PEM or VNR/CDDP), doxorubicin/bleomycin/vinblastine/dacarbazine (ABVd) and rituximab/doxorubicin/cyclophosphamide/vincristine/prendisolone (R-CHOP21), and 2 multiple-day chemotherapy regimens such as 5-fluorouracil/cisplatin (5-FU/CDDP) and bleomycin/etoposide/cisplatin (BEP). Complete response (no emesis, no rescue treatment) during the overall period (days 1-5) was assessed as the primary endpoint. Chemotherapy-induced nausea and vomiting was well-controlled (complete response >70%) in GEM/CDDP and R-CHOP21, but not in other regimens. The effect of a triple antiemetic medication including aprepitant (APR) was subsequently examined in patients receiving EPI/CPA and 5-FU/CDDP. Complete response was significantly improved in patients receiving 5-FU/CDDP but not in those receiving EPI/CPA, although the complete protection from vomiting significantly increased in both cases. Of note, the administration of APR for 5 days, but not for 3 days, was required to completely block the incidence of vomiting during the 7 days of the observation period in patients receiving 5-FU/CDDP. These findings suggest that APR should be used appropriately based on the emetogenicity of HEC regimens.
authors.affiliation: Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu 501-1196;
authors.forename: Shinya
authors.initials: S
authors.lastname: Aoki
authors.affiliation: Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Iihara
authors.affiliation: Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan.
authors.forename: Minako
authors.initials: M
authors.lastname: Nishigaki
authors.affiliation: Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Imanishi
authors.affiliation: Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Yamauchi
authors.affiliation: Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Ishihara
authors.affiliation: Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan.
authors.forename: Kiyoyuki
authors.initials: K
authors.lastname: Kitaichi
authors.affiliation: Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Itoh
keywords: aprepitant; chemotherapy-induced nausea and vomiting; complete response; highly emetogenic chemotherapy; multiple-day chemotherapy regimen; single-day chemotherapy regimen