title: [National network of paediatric central nervous system tumours reviewing by the Groupe d'Étude de Neuropathologie Oncologique Pediatrique (GENOP)].
abstract: Diagnosis of paediatric tumours of the central nervous system is often difficult because WHO classification criteria are mainly defined for adults tumours and do not always apply to their paediatric counterparts. These tumours are rare (400 cases/year among more than 50 pathological subtypes per year in France). Pathological diagnosis may be a challenge for a general pathologist with a too low number of paediatric cases in his recruitment. Hence, a reference group of paediatric neuropathologists was formed (GENOP) on the behalf of the comité "Tumeurs Cérébrales" de la Société Française de lutte contre les Cancers de l'Enfant. This network is supported by the Institut National du Cancer (INCa). GENOP aim is to structure a centralised review of paediatric central nervous system tumours in order to harmonise neuropathological diagnosis at the national level and enhance patients care. Cases assessed during the last 3 years led GENOP to better identify tumours subtypes for which there is a diagnostic challenge. A set of immunohistochemical or molecular specialised techniques was developed, leading to an increased diagnostic accuracy. It allowed a better distinction between diffuse and circumscribed glioma, a better recognition of glioneuronal differentiation and a better subtyping of embryonal tumours such as medulloblastomas. Inter-observer agreement varied according to the tumour subtypes.
authors.affiliation: Neuro-oncology and neuro-inflammation team, Inserm U1028, CNRS UMR 5292, university Lyon-1, neuroscience center, 69000 Lyon, France.
authors.forename: David
authors.initials: D
authors.lastname: Meyronet
authors.affiliation: Neuro-oncology and neuro-inflammation team, Inserm U1028, CNRS UMR 5292, university Lyon-1, neuroscience center, 69000 Lyon, France.
authors.forename: Karen
authors.initials: K
authors.lastname: Silva
authors.affiliation: Inserm, CRO2 UMR_S 911, Aix-Marseille université, 13385 Marseille, France; Service d'anatomie-pathologique et de neuropathologie, hôpital de la Timone, AP-HM, 13385 Marseille, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Figarella-Branger
authors.affiliation: Inserm U823, department of pathology, university Joseph-Fourier, institut Albert-Bonniot, 38043 Grenoble, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Godfraind
authors.affiliation: Inserm CRCT UMR 1037, équipe 5, service d'anatomie-pathologique et d'histologie-cytologie, hôpital de Rangueil, 1, avenue Jean-Poulhes, TSA 50032, 31059 Toulouse, France.
authors.forename: Marie-Bernadette
authors.initials: MB
authors.lastname: Delisle
authors.affiliation: Institut de pathologie, centre de biologie pathologie génétique, CHRU de Lille, CS 70001, 59037 Lille cedex, France; INSERM U837, université Lille-Nord-de-France, 59000 Lille, France.
authors.forename: Claude-Alain
authors.initials: CA
authors.lastname: Maurage
authors.affiliation: Service de neuropathologie, hôpital sainte-Anne, 75674 Paris, France; Université Paris Descartes, Sorbonne Paris-Cité, 75270 Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Miquel
authors.affiliation: Service de neuropathologie, hôpital sainte-Anne, 75674 Paris, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Varlet
authors.affiliation: Service d'oncologie-hématologie, hôpital des enfants de la Timone, Marseille, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Gentet
authors.affiliation: Unité d'hémato-oncologie pédiatrique, 330, avenue de Grande-Bretagne, BP 3119, 31026 Toulouse cedex 3, France.
authors.forename: Anne-Isabelle-Bertozzi
authors.initials: AI
authors.lastname: Salamon
authors.affiliation: Neuro-oncology and neuro-inflammation team, Inserm U1028, CNRS UMR 5292, university Lyon-1, neuroscience center, 69000 Lyon, France; Centre de pathologie et de neuropathologie Est, hospices civils de Lyon, 69003 Lyon, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Vasiljevic
authors.affiliation: Neuro-oncology and neuro-inflammation team, Inserm U1028, CNRS UMR 5292, university Lyon-1, neuroscience center, 69000 Lyon, France; Centre de pathologie et de neuropathologie Est, hospices civils de Lyon, 69003 Lyon, France. Electronic address: anne.jouvet@chu-lyon.fr.
authors.forename: Anne
authors.initials: A
authors.lastname: Jouvet
mesh_terms: D016543:Central Nervous System Neoplasms / Q000473:pathology; D002648:Child; D005602:France; D006801:Humans; D008495:Medical Oncology; D009096:Multi-Institutional Systems; D010372:Pediatrics; D012955:Societies, Medical
keywords: Central nervous system; Double lecture; Network; Paediatric tumours; Pathologic review; Réseau; Système nerveux central; Tumeurs pédiatriques