title: [Triexponential diffusion analysis in invasive ductal carcinoma and fibroadenoma].
abstract: To simultaneously obtain information on diffusion and perfusion in breast lesions by diffusion-weighted magnetic resonance imaging (DWI), we analyzed three diffusion components using a triexponential function. Eighteen subjects [10 with invasive ductal carcinoma (IDC), 8 with fibroadenoma] were evaluated using DWI with multiple b-values. We derived perfusion-related diffusion, fast free diffusion, and slow restricted diffusion coefficients (Dp, Df, Ds) calculated from the triexponential function using the DWI data. Moreover, the triexponential analysis was compared with biexponential and monoexponential analyses. Each diffusion coefficient with a triexponential function was correlated to a relative enhancement ratio (RER) using dynamic contrast-enhanced MRI. In triexponential analysis, Dp and Ds in IDC were significantly higher than those for fibroadenoma. There was no correlation between each diffusion coefficient from the triexponential analysis in any of the groups (Dp, Df, and Ds), but biexponential analysis revealed a positive correlation between each diffusion coefficient in breast lesions. Strong correlations were found between Dp and RERs. Triexponential analysis thus makes it possible to obtain, in noninvasive fashion, more detailed diffusion and perfusion information in breast lesions.
authors.affiliation: Clinical Radiology Service, Kyoto University Hospital.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Tosiaki
authors.initials: T
authors.lastname: Miyati
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Hayashi
authors.forename: Syotaro
authors.initials: S
authors.lastname: Kanao
authors.forename: Masahiro
authors.initials: M
authors.lastname: Taniguchi
authors.forename: Kyoji
authors.initials: K
authors.lastname: Higashimura
authors.forename: Masakazu
authors.initials: M
authors.lastname: Toi
authors.forename: Kaori
authors.initials: K
authors.lastname: Togashi
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D044584:Carcinoma, Ductal / Q000175:diagnosis* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness