title: [Seroprevalence of toxoplasmosis in pregnant women in Annaba, Algeria].
abstract: BACKGROUND
  The aim of the study was to estimate the seroprevalence and risk factors of toxoplasmosis in pregnant women in the department of Annaba, Algeria.
  
  
  METHODS
  We performed a cross-sectional study with analytical purposes. The study was collaboration between the laboratory of Parasitology-Mycology, Faculty of Medicine of Annaba and Parasite Biology Department at the Pasteur Institute of Algeria. A total of 1028 pregnant women who underwent prenatal diagnosis/visit were included over a period of 4 years from January 2006 to December 2009. Immunoglobulin G and M were assayed, using the microparticle enzyme method. The avidity test was used to determine the date of contamination according to age of pregnancy. Search for the parasite was made by inoculation of the placenta and cord blood in white mice. The study compared mother-to-child serological profiles using Western Blot (WB) IgG and IgM. Direct (not well-cooked meat) and indirect (presence of cat, gardening) indicators were recorded to search for parasite exposure.
  
  
  RESULTS
  Seroprevalence was 47.8 % (95 % CI: 44.8 to 51.0) and the rate of active toxoplasmosis was 1.1 % (95 % CI 0.6 to 1.8). According to their immune status, this was the first serology for 41 % (CI95 %: 38.0-44.0) of women; 12 % (CI95 %: 10.5-14.6) of primiparous women had only one serology test during their entire pregnancy. Major risk factors were consumption of poorly-cooked meat and exposure to cats.
  
  
  CONCLUSIONS
  Toxoplasmosis during pregnancy is a serious issue and an effective prevention program is needed.
authors.affiliation: Laboratoire de parasitologie-mycologie, faculté de médecine, Annaba, Algérie. Electronic address: leylamesserer@yahoo.fr.
authors.forename: L
authors.initials: L
authors.lastname: Messerer
authors.affiliation: Service d'épidémiologie et de médecine préventive, CHU d'Annaba, Annaba, Algérie.
authors.forename: S
authors.initials: S
authors.lastname: Bouzbid
authors.affiliation: Service de biologie parasitaire, institut Pasteur d'Algérie, Alger, Algérie.
authors.forename: E
authors.initials: E
authors.lastname: Gourbdji
authors.affiliation: Laboratoire de parasitologie-mycologie, faculté de médecine, Annaba, Algérie.
authors.forename: R
authors.initials: R
authors.lastname: Mansouri
authors.affiliation: Service de biologie parasitaire, institut Pasteur d'Algérie, Alger, Algérie.
authors.forename: F
authors.initials: F
authors.lastname: Bachi
mesh_terms: D000293:Adolescent; D000328:Adult; D000462:Algeria / Q000453:epidemiology; D000913:Antibodies, Protozoan / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000453:epidemiology*; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D014122:Toxoplasma / Q000276:immunology; D014123:Toxoplasmosis / Q000097:blood / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000913:Antibodies, Protozoan
keywords: Algeria; Algérie; Facteurs de risques; Femmes enceintes; Pregnant women; Prevalence; Prévalence; Risk factors; Toxoplasmose; Toxoplasmosis