title: Risk of fracture in patients with Charcot-Marie-Tooth disease.
abstract: BACKGROUND
  In this study we evaluated fracture risk in patients with Charcot-Marie-Tooth (CMT) disease.
  
  
  METHODS
  We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987-2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures.
  
  
  RESULTS
  The risk of non-osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01-2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98-1.74) and AHR 1.10 (95% CI 0.69-1.74), respectively].
  
  
  CONCLUSIONS
  CMT patients have a 1.5-fold increased risk for non-osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture.
authors.affiliation: Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Universiteitsweg 99, 3584, CG Utrecht, The Netherlands.
authors.forename: Sander
authors.initials: S
authors.lastname: Pouwels
authors.forename: Anthonius
authors.initials: A
authors.lastname: de Boer
authors.forename: Hubert G M
authors.initials: HG
authors.lastname: Leufkens
authors.forename: Wim E J
authors.initials: WE
authors.lastname: Weber
authors.forename: Cyrus
authors.initials: C
authors.lastname: Cooper
authors.forename: Frank
authors.initials: F
authors.lastname: de Vries
mesh_terms: D000328:Adult; D015519:Bone Density / Q000502:physiology; D016022:Case-Control Studies; D002607:Charcot-Marie-Tooth Disease / Q000150:complications*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Charcot-Marie-Tooth disease; cohort study; epidemiology, fracture; osteoporosis