title: Evaluation of 3 T pelvic MRI imaging in prostate cancer patients receiving post-prostatectomy IMRT.
abstract: OBJECTIVE
  The purpose of the study was to evaluate the utility of a 3 T pelvic magnetic resonance imaging (MRI) in detecting a local recurrence in post-prostatectomy prostate cancer patients prior to receiving adjuvant or salvage intensity-modulated radiation therapy (IMRT).
  
  
  METHODS
  Ninety prostate cancer patients status post-prostatectomy with rising prostate-specific antigen (PSA) had a 3 T pelvic MRI prior to IMRT. The following variables were analyzed for predicting positive findings on MRI: initial presenting and initial post-op PSA, PSA at the time of imaging, PSA velocity, surgical margins, Gleason score, pathological stage, pre-RT digital rectal examination, and type of surgical prostatectomy.
  
  
  RESULTS
  The only significant variable predictive of a positive MRI was positive margins. Specifically, 15 of 46 (33 %) patients with positive margins had a positive MRI, while 5 of 44 (11 %) patients with negative margins had a positive MRI. In the MRI positive group, the location of the positive findings on MRI corresponded with the pathology report in 9 of 12 (75 %) cases.
  
  
  CONCLUSIONS
  Post-prostatectomy patients with pathologic positive margins are three times more likely to have positive findings on a 3 T MRI.
authors.affiliation: Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Verma
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Jeff M
authors.initials: JM
authors.lastname: Michalski
authors.forename: Yanle
authors.initials: Y
authors.lastname: Hu
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhang
authors.forename: Kathryn
authors.initials: K
authors.lastname: Robinson
authors.forename: Shivam
authors.initials: S
authors.lastname: Verma
authors.forename: Laura
authors.initials: L
authors.lastname: Eschen
authors.forename: Sandra
authors.initials: S
authors.lastname: Fergus
authors.forename: Dan
authors.initials: D
authors.lastname: Mullen
authors.forename: Seth
authors.initials: S
authors.lastname: Strope
authors.forename: Robert
authors.initials: R
authors.lastname: Grubb
authors.forename: Hiram A
authors.initials: HA
authors.lastname: Gay
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D018365:Neoplasm, Residual; D017430:Prostate-Specific Antigen; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery*; D018714:Radiotherapy, Adjuvant; D050397:Radiotherapy, Intensity-Modulated; D016879:Salvage Therapy; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D017430:Prostate-Specific Antigen