title: Geno-geographic origin of Y-specific STR haplotypes in a sample of Caucasian-Mestizo and African-descent male individuals from Colombia.
abstract: BACKGROUND
  Y chromosome STR haplotypes have been widely used in population studies to establish the origin of diverse populations.
  
  
  OBJECTIVE
  We analyzed Y chromosome STR haplotypes (8 loci) in 134 Caucasian-mestizo and 137 African-descent Colombian unrelated individuals to correlate the geographical origin with historical data as well as the genetic relationships and possible admixture patterns.
  
  
  METHODS
  One hundred samples of African descent and 137 Caucasian-mestizo samples analyzed for Y chromosome STR haplotypes by PCR followed by acrylamide electrophoresis.
  
  
  RESULTS
  No evidence of population substructure was found for the African descent. Two point fifty nine per cent of the haplotypes were shared between the two groups with the possible existence of Caucasian gene flow towards Afro-descendants.
  
  
  CONCLUSIONS
  The Caucasian-Mestizo Colombian population is grouped with other populations of the Iberian Peninsula and Europe, while the Afro-Colombian population is grouped with other African populations reported.
authors.affiliation: Departamento de Patología, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C, Colombia.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Yunis
authors.affiliation: Departamento de Biología, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá, D.C, Colombia.
authors.forename: Luis E
authors.initials: LE
authors.lastname: Acevedo
authors.affiliation: Departamento de Biología, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá, D.C, Colombia.
authors.forename: David S
authors.initials: DS
authors.lastname: Campo
authors.affiliation: Servicios Médicos Yunis Turbay y Cía, Bogotá, D.C, Colombia.
authors.forename: Emilio J
authors.initials: EJ
authors.lastname: Yunis
mesh_terms: D044383:Black People / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D003105:Colombia; D005843:Geography; D006239:Haplotypes; D006801:Humans; D008297:Male; D044465:White People / Q000235:genetics*