title: Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid.
abstract: BACKGROUND
  Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.
  
  
  METHODS
  Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.
  
  
  RESULTS
  The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.
  
  
  CONCLUSIONS
  Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.
authors.affiliation: Blegdamsvej 3B, 2200 Copenhagen N, Denmark. hudada@sund.ku.dk.
authors.forename: Huda S
authors.initials: HS
authors.lastname: Darusman
authors.forename: Jacub
authors.initials: J
authors.lastname: Pandelaki
authors.forename: Rahmad
authors.initials: R
authors.lastname: Mulyadi
authors.forename: Dondin
authors.initials: D
authors.lastname: Sajuthi
authors.forename: Indah A
authors.initials: IA
authors.lastname: Putri
authors.forename: Otto H
authors.initials: OH
authors.lastname: Kalliokoski
authors.forename: Josep
authors.initials: J
authors.lastname: Call
authors.forename: Klas S P
authors.initials: KS
authors.lastname: Abelson
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Schapiro
authors.forename: Albert
authors.initials: A
authors.lastname: Gjedde
authors.forename: Jann
authors.initials: J
authors.lastname: Hau
mesh_terms: D000367:Age Factors; D000375:Aging; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D000818:Animals; D001284:Atrophy; D015415:Biomarkers; D004195:Disease Models, Animal; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D008252:Macaca fascicularis; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D016875:tau Proteins
keywords: Neurodegenerative disease; biomarkers; magnetic resonance imaging; memory; non-human primate