title: The role of biophysical parameters in the antilipopolysaccharide activities of antimicrobial peptides from marine fish.
abstract: Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties of AMPs. In this review, therefore, we will focus on the physiochemical properties of AMPs; that is, the contributions made by their sequences, net charge, hydrophobicity and amphipathicity to their mechanism of action. Moreover, the interactions between LPS and fish AMPs and the structure of fish AMPs with LPS bound will also be discussed. A better understanding of the biophysical properties will be useful in the design of AMPs effective against septic shock and multidrug-resistant bacterial strains, including those that commonly produce wound infections.
authors.affiliation: Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Korea. ramagopa@gmail.com.
authors.forename: Ramamourthy
authors.initials: R
authors.lastname: Gopal
authors.affiliation: Department of Bioinformatics, Kongju National University, Kongju 314-701, Korea. chseo@kongju.ac.kr.
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Seo
authors.affiliation: Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Korea. y_k_park@chosun.ac.kr.
authors.forename: Yoonkyung
authors.initials: Y
authors.lastname: Park
mesh_terms: D000595:Amino Acid Sequence; D043925:Angiogenesis Inducing Agents / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D003386:Brachyura / Q000378:metabolism; D005399:Fishes / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006737:Horseshoe Crabs; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors*; D008969:Molecular Sequence Data; D008121:Nephropidae; D033561:Penaeidae; D017747:Seafood / Q000032:analysis; D012623:Seawater; D014945:Wound Healing / Q000187:drug effects
chemical_list: D043925:Angiogenesis Inducing Agents; D000893:Anti-Inflammatory Agents; D023181:Antimicrobial Cationic Peptides; D008070:Lipopolysaccharides