title: Do the abnormal results of an implantation renal biopsy affect the donor renal function?
abstract: BACKGROUND
  Living kidney donation has become an important source for renal transplantation. Thus, renal function after donation is an important issue. In this study, we examined histological abnormalities in implantation biopsy specimens from living kidney donors and analyzed the renal function of the remaining kidney.
  
  
  METHODS
  Using the 2007 Banff classification system, we analyzed 121 kidneys from living donors who underwent implantation biopsies (IBs) between 2010 and 2011. Donor characteristics, intraoperative factors, and perioperative renal functions, such as serum creatinine and glomerular filtration rate (GFR), were evaluated. Univariate and multivariate regression analyses were performed to identify the factors related to each histological abnormality and postoperative 1-year donor renal function.
  
  
  RESULTS
  Most histological abnormalities in healthy living donors were scored as 1 on the Banff scale. Univariate and multivariate analyses revealed that donor age was the only preoperative factor related to tubular atrophy (odds ratio [OR] = 1.104; P = .012) and glomerular sclerosis (OR = 1.050; P = .019). Intraoperative factors were not related to histological parameters. And histological abnormalities did not affect postoperative 1-year renal function. In contrast, donor age, preoperative GFR, and estimated blood loss were significantly related to 1-year postoperative GFR.
  
  
  CONCLUSIONS
  Most histological abnormalities in healthy living donors were minor. The incidence of abnormalities correlated with donor age. However, postoperative renal functions in living donors were not affected by histological abnormalities. Larger-scale investigations with long-term follow-up analysis will be needed.
authors.affiliation: Department of Urology, Urological Science Institute, Ewha Womans University Mokdong Hospital, Seoul, Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Choi
authors.affiliation: Department of Urology, Urological Science Institute, Ewha Womans University Mokdong Hospital, Seoul, Korea.
authors.forename: S C
authors.initials: SC
authors.lastname: Yang
authors.affiliation: Department of Surgery, The Research Institute for Transplantation, Yonsei University College of Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea.
authors.forename: D J
authors.initials: DJ
authors.lastname: Joo
authors.affiliation: Department of Urology, Urological Science Institute, Ewha Womans University Mokdong Hospital, Seoul, Korea.
authors.forename: Y E
authors.initials: YE
authors.lastname: Yoon
authors.affiliation: Department of Urology, Ewha Womans University Mokdong Hospital, Seoul, Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Urology, Urological Science Institute, Ewha Womans University Mokdong Hospital, Seoul, Korea.
authors.forename: K
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Surgery, The Research Institute for Transplantation, Yonsei University College of Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea.
authors.forename: M S
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Surgery, The Research Institute for Transplantation, Yonsei University College of Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea.
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Surgery, The Research Institute for Transplantation, Yonsei University College of Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea.
authors.forename: S I
authors.initials: SI
authors.lastname: Kim
authors.affiliation: Department of Urology, Urological Science Institute, Ewha Womans University Mokdong Hospital, Seoul, Korea. Electronic address: hanwk@yuhs.ac.
authors.forename: W K
authors.initials: WK
authors.lastname: Han
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000503:physiopathology; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors