title: Differentiating amorphous mixtures of cefuroxime axetil and copovidone by X-ray diffraction and differential scanning calorimetry.
abstract: The amorphous, molecular solid dispersion of cefuroxime axetil and copovidone with the mass ratio 71/29 is compared to its pure components in the amorphous state and to an amorphous mechanical mixture with the same mass ratio. Calorimetric studies demonstrate that all these materials are vitreous. By using X-ray diffraction profiles, a clear difference can be observed between the local order of the solid dispersion and that of the mechanical mixture. More generally, it is shown how the presence or absence of additivity in the diffraction data can be used to distinguish between different amorphous mixtures.
authors.affiliation: Laboratoire de chimie physique (EA4066), faculté de pharmacie, 4, avenue de l'Observatoire, 75006 Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Nicolaï
authors.affiliation: Laboratoire de chimie physique (EA4066), faculté de pharmacie, 4, avenue de l'Observatoire, 75006 Paris, France.
authors.forename: M-A
authors.initials: MA
authors.lastname: Perrin
authors.affiliation: Laboratoire de chimie physique (EA4066), faculté de pharmacie, 4, avenue de l'Observatoire, 75006 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Céolin
authors.affiliation: Laboratoire de chimie physique (EA4066), faculté de pharmacie, 4, avenue de l'Observatoire, 75006 Paris, France. Electronic address: ivo.rietveld@parisdescartes.fr.
authors.forename: I B
authors.initials: IB
authors.lastname: Rietveld
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002151:Calorimetry; D002152:Calorimetry, Differential Scanning; D002444:Cefuroxime / Q000031:analogs & derivatives* / Q000737:chemistry; D010592:Pharmaceutic Aids / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D010592:Pharmaceutic Aids; D011205:Povidone; D002444:Cefuroxime; C040738:cefuroxime axetil
keywords: Active pharmaceutical ingredient–excipient interaction; Amorphous state; Dispersion solide; Interaction principe actif–excipient; Local order; Ordre local; Solid dispersion; Vitreous state; État amorphe; État vitreux