title: The seroprevalence of parvovirus B19 infection in pregnant women in Sudan.
abstract: Parvovirus B19 (B19V) infection during pregnancy may have serious consequences like fetal anaemia, hydrops fetalis, and fetal loss. Since epidemiological data on B19V infection are generally lacking in Sudan, the current study aimed to determine the seroprevalence of B19V in Sudanese pregnant women. Five hundred women, attending antenatal clinics in Khartoum state between November 2008 and March 2009, were enrolled and screened for B19V IgG and IgM antibodies by enzyme immunoassays. The study revealed a B19V IgG seroprevalence of 61·4%, with one subject positive for IgM. B19V DNA was not detected by PCR in any of the tested individuals. B19V IgG seroprevalence was significantly correlated with multigravidity (P = 0·046). Our data showed that B19V infection is prevalent in Sudan and we recommend further studies in Sudanese women, particularly in those with complications and adverse outcomes of pregnancy.
authors.affiliation: Department of Medical Biotechnology,Commission for Biotechnology and Genetic Engineering,the National Centre for Research, Khartoum,Sudan.
authors.forename: O
authors.initials: O
authors.lastname: Adam
authors.affiliation: Department of Medical Biotechnology,Commission for Biotechnology and Genetic Engineering,the National Centre for Research, Khartoum,Sudan.
authors.forename: T
authors.initials: T
authors.lastname: Makkawi
authors.affiliation: Institute of Virology,University of Bonn Medical Centre,Bonn,Germany.
authors.forename: U
authors.initials: U
authors.lastname: Reber
authors.affiliation: Institute of Virology,University of Bonn Medical Centre,Bonn,Germany.
authors.forename: H
authors.initials: H
authors.lastname: Kirberg
authors.affiliation: Institute of Virology,University of Bonn Medical Centre,Bonn,Germany.
authors.forename: A M
authors.initials: AM
authors.lastname: Eis-Hübinger
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D010322:Parvoviridae Infections / Q000453:epidemiology*; D016732:Parvovirus B19, Human; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors; D013397:Sudan / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M