title: Anti-CCP antibodies in Brazilian children and adults with juvenile idiopathic arthritis.
abstract: Patients with juvenile idiopathic arthritis (JIA) may need further care in the adult clinic as this disease frequently has continuous inflammatory activity during adult life. To identify which pediatric JIA patients will need continuing care into adulthood. We compared the clinical, serological, and demographic data of 45 JIA patients followed up by the pediatric clinic to those of 49 JIA patients in the adult rheumatology clinic. Patients in the adult clinic have older age at disease onset (p < 0.0001) and higher prevalence of positive anti-cyclic citrullinated peptide (CCP) (p = 0.05). No differences were observed in JIA form, presence of rheumatoid factor (RF), uveitis, and gender. Anti-CCP and older age at disease onset may identify pediatric JIA patients that will need further care in the adult clinic.
authors.affiliation: Rheumatology Unit, Evangelical University, Curitiba, Paraná, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Bacos
authors.forename: S G
authors.initials: SG
authors.lastname: Bortolozzi
authors.forename: T S
authors.initials: TS
authors.lastname: Skare
authors.forename: P F
authors.initials: PF
authors.lastname: Spelling
authors.forename: S R R
authors.initials: SR
authors.lastname: Utiyama
authors.forename: R
authors.initials: R
authors.lastname: Nisihara
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000906:Antibodies / Q000276:immunology*; D001171:Arthritis, Juvenile / Q000097:blood / Q000150:complications / Q000276:immunology*; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010372:Pediatrics / Q000379:methods; D010456:Peptides, Cyclic / Q000276:immunology*; D012217:Rheumatoid Factor / Q000276:immunology; D012737:Sex Factors; D060305:Transition to Adult Care; D014605:Uveitis / Q000150:complications / Q000276:immunology; D055815:Young Adult
chemical_list: D000906:Antibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor