title: Verbal repetition in primary progressive aphasia and Alzheimer's disease.
abstract: We aimed to explore the nature of verbal repetition deficits and infer the cognitive systems involved in primary progressive aphasia (PPA) and Alzheimer's disease (AD). A total of 63 patients (13 semantic variant (sv-PPA), 17 nonfluent/agrammatic variant (nfv-PPA), 10 logopenic variant (lv-PPA), 23 AD) and 13 matched healthy controls completed a battery of tests that included naming, word comprehension, digit span, repetition of multisyllabic single words, monosyllabic word span presented under similar and dissimilar phonological conditions, and sentence repetition. All patient groups displayed some level of impairment, however, specific patterns emerged in each variant. Participants with sv-PPA were the least impaired, showing marginal difficulties exclusively for sentence repetition, whereas those with lv-PPA had the worst overall performance. Cases with nfv-PPA showed compromised repetition of multisyllabic and phonologically similar words. The deficit in cases with AD was confined to span tasks. These distinctive patterns of language impairments can assist in the differential diagnosis of PPA variants and point toward the vulnerability of specific cognitive systems in each syndrome.
authors.affiliation: Neuroscience Research Australia, Sydney, NSW, Australia ARC Centre of Excellence in Cognition and its Disorders, NSW, Australia Faculty of Health Sciences, The University of Sydney, NSW, Australia.
authors.forename: Cristian E
authors.initials: CE
authors.lastname: Leyton
authors.affiliation: Neuroscience Research Australia, Sydney, NSW, Australia School of Medical Sciences, The University of New South Wales, NSW, Australia.
authors.forename: Sharon
authors.initials: S
authors.lastname: Savage
authors.affiliation: Neuroscience Research Australia, Sydney, NSW, Australia ARC Centre of Excellence in Cognition and its Disorders, NSW, Australia School of Psychology, The University of New South Wales, NSW, Australia.
authors.forename: Muireann
authors.initials: M
authors.lastname: Irish
authors.affiliation: Neuroscience Research Australia, Sydney, NSW, Australia.
authors.forename: Samantha
authors.initials: S
authors.lastname: Schubert
authors.affiliation: Neuroscience Research Australia, Sydney, NSW, Australia ARC Centre of Excellence in Cognition and its Disorders, NSW, Australia School of Medical Sciences, The University of New South Wales, NSW, Australia.
authors.forename: Olivier
authors.initials: O
authors.lastname: Piguet
authors.affiliation: Neuroscience Research Australia, Sydney, NSW, Australia Faculty of Health Sciences, The University of Sydney, NSW, Australia.
authors.forename: Kirrie J
authors.initials: KJ
authors.lastname: Ballard
authors.affiliation: Neuroscience Research Australia, Sydney, NSW, Australia ARC Centre of Excellence in Cognition and its Disorders, NSW, Australia School of Medical Sciences, The University of New South Wales, NSW, Australia.
authors.forename: John R
authors.initials: JR
authors.lastname: Hodges
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D018888:Aphasia, Primary Progressive / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007807:Language Tests; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010700:Phonetics; D013060:Speech
keywords: Alzheimer's disease; logopenic variant; non-fluent agrammatic variant; primary progressive aphasia; semantic variant; verbal repetition