title: Erythroderma secondary to gliclazide: a case report.
abstract: Erythroderma is generalized exfoliative dermatitis, which involves more than 90% of the patient's skin. The most common cause of erythroderma is exacerbation of an underlying skin disease, malignancies or drug reaction. There is a long list of drugs responsible for erythroderma such as antiepileptics, sulfonamides, antibiotics, and angiotensin converting enzyme (ACE) inhibitors. We herein report a case of erythroderma due to gliclazide usage which is also proved by histopathologic examination and patch test. We could not find any case report of gliclazide, an oral antidiabetic, as a cause erythroderma in the literature.
authors.affiliation: Department of Dermatology .
authors.forename: Pinar
authors.initials: P
authors.lastname: Ozuguz
authors.forename: Seval Dogruk
authors.initials: SD
authors.lastname: Kacar
authors.forename: Ufuk
authors.initials: U
authors.lastname: Ozuguz
authors.forename: Semsettin
authors.initials: S
authors.lastname: Karaca
authors.forename: Cigdem
authors.initials: C
authors.lastname: Tokyol
mesh_terms: D000368:Aged; D003873:Dermatitis, Exfoliative / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D003875:Drug Eruptions / Q000473:pathology; D005260:Female; D005907:Gliclazide / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D012882:Skin Tests
chemical_list: D007004:Hypoglycemic Agents; D005907:Gliclazide
keywords: Drug eruption; erythroderma; gliclazide