title: Sickle cell disease and posterior reversible leukoencephalopathy.
abstract: Sickle cell disease can present with neurological manifestations. One such presentation is with posterior reversible leukoencephalopathy also known as reversible posterior leukoencephalopathy. The condition is classically described as reversible over time; it commonly presents with oedematous changes involving the white matter of the occipital and parietal regions. Only a few patients with the association between sickle cell disease and posterior reversible leukoencephalopathy have been described in the adult literature. We present two patients from our institutions to emphasise the association between the two conditions and summarise the published cases in the literature.
authors.affiliation: Department of Neurology, Royal North Shore Hospital, Reserve Road, St Leonards, Sydney, NSW 2065, Australia; Western Clinical School, University of Sydney, Sydney, NSW, Australia. Electronic address: ngeevasi@med.usyd.edu.au.
authors.forename: Nimeshan
authors.initials: N
authors.lastname: Geevasinga
authors.affiliation: School of Paediatrics and Child Health, University of Western Australia, Crawley, WA, Australia; Departments of Paediatric and Adolescent Haematology and Oncology, Princess Margaret Hospital for Children, Perth, WA, Australia.
authors.forename: Catherine
authors.initials: C
authors.lastname: Cole
authors.affiliation: Department of Neurology, Royal North Shore Hospital, Reserve Road, St Leonards, Sydney, NSW 2065, Australia; Northern Clinical School, University of Sydney, Sydney, NSW, Australia.
authors.forename: Geoffrey K
authors.initials: GK
authors.lastname: Herkes
authors.affiliation: Department of Radiology, Royal North Shore Hospital, Sydney, NSW, Australia; Brain and Mind Research Institute, Camperdown, NSW, Australia.
authors.forename: Yael
authors.initials: Y
authors.lastname: Barnett
authors.affiliation: Department of Neurology, Royal North Shore Hospital, Reserve Road, St Leonards, Sydney, NSW 2065, Australia.
authors.forename: Jamie
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Neurology, Royal North Shore Hospital, Reserve Road, St Leonards, Sydney, NSW 2065, Australia; Northern Clinical School, University of Sydney, Sydney, NSW, Australia.
authors.forename: Merrilee
authors.initials: M
authors.lastname: Needham
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D054038:Posterior Leukoencephalopathy Syndrome / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy
keywords: Posterior leukoencephalopathy syndrome; Reversible posterior leukoencephalopathy syndrome; Sickle cell anaemia; Sickle cell disease