title: Framework for rapid assessment and adoption of new vector control tools.
abstract: Evidence-informed health policy making is reliant on systematic access to, and appraisal of, the best available research evidence. This review suggests a strategy to improve the speed at which evidence is gathered on new vector control tools (VCTs) using a framework based on measurements of the vectorial capacity of an insect population to transmit disease. We explore links between indicators of VCT efficacy measurable in small-scale experiments that are relevant to entomological and epidemiological parameters measurable only in large-scale proof-of-concept randomised control trials (RCTs). We hypothesise that once RCTs establish links between entomological and epidemiological indicators then rapid evaluation of new products within the same product category may be conducted through smaller scale experiments without repetition of lengthy and expensive RCTs.
authors.affiliation: Innovative Vector Control Consortium (IVCC), Liverpool, UK; Department of Biology, University of Crete, Heraklion, Greece. Electronic address: vontas@biology.uoc.gr.
authors.forename: John
authors.initials: J
authors.lastname: Vontas
authors.affiliation: Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania; Health Interventions Unit, Swiss TPH, Socinstrasse 57, Basel, Switzerland; University of Basel, Petersplatz 1, Basel, Switzerland.
authors.forename: Sarah
authors.initials: S
authors.lastname: Moore
authors.affiliation: MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Immo
authors.initials: I
authors.lastname: Kleinschmidt
authors.affiliation: Department of Vector Biology, Liverpool School Tropical Medicine, Liverpool, UK.
authors.forename: Hilary
authors.initials: H
authors.lastname: Ranson
authors.affiliation: School of Biological and Biomedical Sciences, Durham University, Durham, UK.
authors.forename: Steve
authors.initials: S
authors.lastname: Lindsay
authors.affiliation: Health Interventions Unit, Swiss TPH, Socinstrasse 57, Basel, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Lengeler
authors.affiliation: Innovative Vector Control Consortium (IVCC), Liverpool, UK.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Hamon
authors.affiliation: Innovative Vector Control Consortium (IVCC), Liverpool, UK.
authors.forename: Tom
authors.initials: T
authors.lastname: McLean
authors.affiliation: Innovative Vector Control Consortium (IVCC), Liverpool, UK; Department of Vector Biology, Liverpool School Tropical Medicine, Liverpool, UK.
authors.forename: Janet
authors.initials: J
authors.lastname: Hemingway
mesh_terms: D000818:Animals; D003257:Consumer Product Safety; D008288:Malaria / Q000517:prevention & control; D009032:Mosquito Control / Q000592:standards*; D013673:Technology Assessment, Biomedical; D054928:Validation Studies as Topic
keywords: efficacy; entomological parameters; vector control tool; vectorial capacity