title: Current advances in animal model of chondrosarcoma and related research.
abstract: Chondrosarcoma is a type of malignant cartilage tumor with a high local recurrence. Due to its resistance to chemo- and radiotherapy, current treatment is limited to surgical resection. Animal model is one of the most important approaches to studying this disease, although systematic reporting on its development is rare. In this review, we summarized the elements involving animal model establishment. On the basis of these elements, we further classified chondrosarcoma animal models into various types. In addition, we compared various measurements for evaluating the animal model. Finally, its specific applications were discussed.
authors.affiliation: Musculoskeletal Oncology Center;
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Liao
authors.affiliation: Musculoskeletal Oncology Center;
authors.forename: Ying-Qi
authors.initials: YQ
authors.lastname: Hua
authors.affiliation: Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.
authors.forename: Zheng-Dong
authors.initials: ZD
authors.lastname: Cai
keywords: allograft; animal model; chondrosarcoma; heterotopic; orthotopic; xenograft