title: Extracellular matrix and wound healing.
abstract: Extracellular matrix has been known for a long time as an architectural support for the tissues. Many recent data, however, have shown that extracellular matrix macromolecules (collagens, elastin, glycosaminoglycans, proteoglycans and connective tissue glycoproteins) are able to regulate many important cell functions, such as proliferation, migration, protein synthesis or degradation, apoptosis, etc., making them able to play an important role in the wound repair process. Not only the intact macromolecules but some of their specific domains, that we called "Matrikines", are also able to regulate many cell activities. In this article, we will summarize main findings showing the effects of extracellular matrix macromolecules and matrikines on connective tissue and epithelial cells, particularly in skin, and their potential implication in the wound healing process. These examples show that extracellular matrix macromolecules or some of their specific domains may play a major role in wound healing. Better knowledge of these interactions may suggest new therapeutic targets in wound healing defects.
authors.affiliation: Laboratoire de biochimie et biologie moléculaire, CNRS FRE 3481, faculté de médecine, 51, rue Cognacq-Jay, CS 30018, 51095 Reims, France; Laboratoire central de biochimie, CHU de Reims, rue Serge-Kochman, 51092 Reims, France. Electronic address: fmaquart@chu-reims.fr.
authors.forename: F X
authors.initials: FX
authors.lastname: Maquart
authors.affiliation: Laboratoire de biochimie et biologie moléculaire, CNRS FRE 3481, faculté de médecine, 51, rue Cognacq-Jay, CS 30018, 51095 Reims, France; Laboratoire central de biochimie, CHU de Reims, rue Serge-Kochman, 51092 Reims, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Monboisse
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D015687:Cell Hypoxia; D003238:Connective Tissue / Q000378:metabolism / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000502:physiology; D005337:Fibrin / Q000502:physiology; D006025:Glycosaminoglycans / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology; D010446:Peptide Fragments / Q000502:physiology; D010447:Peptide Hydrolases / Q000378:metabolism; D011509:Proteoglycans / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
chemical_list: D016326:Extracellular Matrix Proteins; D006025:Glycosaminoglycans; D016023:Integrins; D010446:Peptide Fragments; D011509:Proteoglycans; D005337:Fibrin; D010447:Peptide Hydrolases
keywords: Cicatrisation; Collagen; Collagène; Connective tissue glycoproteins; Elastin; Extracellular matrix; Glycoprotéines du tissu conjonctif; Glycosaminoglycannes; Glycosaminoglycans; Matrice extracellulaire; Matrikines; Proteoglycans; Protéoglycannes; Wound healing; Élastine