title: Anti-ST2 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected mice.
abstract: OBJECTIVE
  Interleukin-33 (IL-33) could play an important role in the pathogenesis of angiostrongylosis. However, the role of IL-33/ST2 pathway in this parasitic infection is uncertain.
  
  
  METHODS
  C57BL/six mice were each infected with 35 Angiostrongylus cantonensis larvae. One group of mice received an intraperitoneal injection of anti-ST2 monoclonal antibody (mAb; 50 μg) 3 days postinfection and subsequent booster shots of the same dose at 5-day intervals. Blood samples from each group were collected every week for assays.
  
  
  RESULTS
  The level of IL-5 significantly decreased in the mAb-treated group, and the infiltration of eosinophils in the meninges was also significantly reduced.
  
  
  CONCLUSIONS
  The IL-33/ST2 axis may play a crucial role in the pathogenesis of angiostrongylosis and the results of this study could be useful for the development of strategies to reduce the neurological damage caused by this parasitic infection.
authors.affiliation: School of Medicine, Fu Jen Catholic University, Xinzhuang, New Taipei City, Taiwan; Section of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Chuang
authors.affiliation: Department of Cosmetic Science, Vanung University, Zhongli City, Taoyuan, Taiwan.
authors.forename: Chi-Wu
authors.initials: CW
authors.lastname: Chen
authors.affiliation: School of Medicine, Fu Jen Catholic University, Xinzhuang, New Taipei City, Taiwan.
authors.forename: Yu-Tzu
authors.initials: YT
authors.lastname: Huang
authors.affiliation: School of Medicine, Fu Jen Catholic University, Xinzhuang, New Taipei City, Taiwan. Electronic address: 059262@mail.fju.edu.tw.
authors.forename: Wen-Yuan
authors.initials: WY
authors.lastname: Du
mesh_terms: D017185:Angiostrongylus cantonensis / Q000276:immunology*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D004804:Eosinophils / Q000276:immunology*; D000072179:Interleukin-1 Receptor-Like 1 Protein; D008297:Male; D008578:Meninges / Q000473:pathology*; D008810:Mice, Inbred C57BL; D018123:Receptors, Interleukin / Q000037:antagonists & inhibitors*; D017206:Strongylida Infections / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; C486189:Il1rl1 protein, mouse; D000072179:Interleukin-1 Receptor-Like 1 Protein; D018123:Receptors, Interleukin
keywords: Angiostrongylus cantonensis; Interleukin-33; ST2