title: The paradox of IL-10-mediated modulation in cervical cancer.
abstract: Interleukin-10 (IL-10) has opposing effects as an anti-inflammatory (potentially cancer-promoting) and antiangiogenic (potentially cancer-inhibiting) agent. The role of IL-10 in cervical cancer is also dual. Here, we review the IL-10-mediated tumor-promoting effect and tumor-inhibiting effects in cervical cancer, among which, human papilloma virus (HPV), human leukocyte antigen-G (HLA-G) and IL-10 polymorphisms are associated with the development of cervical cancer. IL-10 is also used for the therapy of cervical cancer through enhancing proliferation, expression of immunologically important surface molecules and increasing Th1 cytokine production and cytotoxic potential in HPV-specific CD8 (+) cytotoxic T lymphocytes.
authors.affiliation: Department of Gynaecology and Obstetrics, Affiliated Hospital of Hebei United University;
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Departments of Pharmacy, Tangshan, Hebei 063000, P.R. China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Liu
authors.affiliation: Gynaecology and Obstetrics, Tangshan Gongren Hospital, Tangshan, Hebei 063000, P.R. China.
authors.forename: Yue-Hong
authors.initials: YH
authors.lastname: Li
authors.affiliation: Gynaecology and Obstetrics, Tangshan Gongren Hospital, Tangshan, Hebei 063000, P.R. China.
authors.forename: Ou
authors.initials: O
authors.lastname: Li
keywords: cervical cancer; interleukin-10; paradox