title: High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: a randomized, controlled pilot trial.
abstract: OBJECTIVE
  To determine the effects of high-dose vitamin D on insulin sensitivity in polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Randomized, placebo-controlled trial.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  Twenty-eight women with PCOS.
  
  
  METHODS
  Vitamin D3, 12,000 IU, or placebo daily for 12 weeks.
  
  
  METHODS
  The primary outcome was quantitative insulin sensitivity check index. Secondary outcomes included glucose and insulin levels during a 75-g oral glucose tolerance test and blood pressure.
  
  
  RESULTS
  Twenty-two women completed the study. Compared with placebo, vitamin D significantly increased 25-hydroxyvitamin D (mean [95% confidence interval] in vitamin D group 20.1 [15.7 to 24.5] ng/mL at baseline and 65.7 [52.3 to 79.2] ng/mL at 12 weeks; placebo 22.5 [18.1 to 26.8] ng/mL at baseline and 23.8 [10.4 to 37.2] ng/mL at 12 weeks). There were no significant differences in quantitative insulin sensitivity check index and other measures of insulin sensitivity; however, we observed trends toward lower 2-hour insulin and lower 2-hour glucose. We also observed a protective effect of vitamin D on blood pressure.
  
  
  CONCLUSIONS
  In women with PCOS, insulin sensitivity was unchanged with high-dose vitamin D, but there was a trend toward decreased 2-hour insulin and a protective effect on blood pressure.
  
  
  BACKGROUND
  NCT00907153.
authors.affiliation: Division of Endocrinology, Diabetes, and Metabolism, Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Electronic address: nrajakhan@psu.edu.
authors.forename: Nazia
authors.initials: N
authors.lastname: Raja-Khan
authors.affiliation: Division of Endocrinology, Diabetes, and Metabolism, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
authors.forename: Julie
authors.initials: J
authors.lastname: Shah
authors.affiliation: Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
authors.forename: Christy M
authors.initials: CM
authors.lastname: Stetter
authors.affiliation: Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
authors.forename: Mary E J
authors.initials: ME
authors.lastname: Lott
authors.affiliation: Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
authors.forename: Allen R
authors.initials: AR
authors.lastname: Kunselman
authors.affiliation: Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
authors.forename: William C
authors.initials: WC
authors.lastname: Dodson
authors.affiliation: Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Legro
mesh_terms: D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002762:Cholecalciferol / Q000008:administration & dosage*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008875:Middle Aged; D010414:Pennsylvania; D010865:Pilot Projects; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome; D014815:Vitamins / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D014815:Vitamins; D002762:Cholecalciferol
keywords: Polycystic ovary syndrome; blood pressure; insulin resistance; vitamin D