title: New pharmacological treatment options for chronic constipation.
abstract: BACKGROUND
  A number of new medications were recently demonstrated to be more effective than placebo in treating chronic constipation, including the intestinal chloride channel activator lubiprostone, the prokinetic selective 5-HT4 receptor agonist prucalopride and the guanylate cyclase-C agonist linaclotide. Recent publications have also revisited traditional laxatives like PEG. Moreover, a number of pharmacological treatments are in development and these include another guanylate cyclase-C agonist, plecanatide and an ileal bile acid transporter inhibitor, elobixibat.
  
  
  METHODS
  This review focuses on the pharmacology, efficacy and safety profile of prucalopride, linaclotide, plecanatide and elobixibat.
  
  
  CONCLUSIONS
  The possible present or future clinical application of prucalopride, linaclotide, plecanatide and elobixibat in both chronic constipation and irritable bowel syndrome with constipation is reported, and some considerations on the possible role of PEG taking into account recent literature are advanced.
authors.affiliation: University of Leuven, Translational Research Center for Gastrointestinal Disorders , Herestraat 49, 3000 Leuven , Belgium.
authors.forename: Maura
authors.initials: M
authors.lastname: Corsetti
authors.forename: Jan
authors.initials: J
authors.lastname: Tack
mesh_terms: D001572:Benzofurans / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D003248:Constipation / Q000150:complications / Q000188:drug therapy*; D004151:Dipeptides / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000188:drug therapy; D054368:Laxatives / Q000009:adverse effects / Q000627:therapeutic use*; D045265:Natriuretic Peptides / Q000009:adverse effects / Q000627:therapeutic use*; D010455:Peptides / Q000009:adverse effects / Q000627:therapeutic use*; D013841:Thiazepines / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D001572:Benzofurans; D004151:Dipeptides; D054368:Laxatives; D045265:Natriuretic Peptides; D010455:Peptides; D013841:Thiazepines; C406662:prucalopride; C584575:plecanatide; C581303:elobixibat; C523483:linaclotide