title: Acute toxicity of nickel nanoparticles in rats after intravenous injection.
abstract: This study was carried out to add scientific data in regard to the use of metallic nanoparticles in nanomedicine. The acute toxicity of nickel (Ni) nanoparticles (50 nm), intravenously injected through the dorsal penile vein of Sprague Dawley rats was evaluated in this study. Fourteen days after injection, Ni nanoparticles induced liver and spleen injury, lung inflammation, and caused cardiac toxicity. These results indicate that precautionary measures should be taken with regard to the use of Ni nanoparticles or Ni compounds in nanomedicine.
authors.affiliation: Public Health Department, Ningbo University, People's Republic of China.
authors.forename: Ruth R
authors.initials: RR
authors.lastname: Magaye
authors.affiliation: Public Health Department, Ningbo University, People's Republic of China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yue
authors.affiliation: Public Health Department, Ningbo University, People's Republic of China.
authors.forename: Baobo
authors.initials: B
authors.lastname: Zou
authors.affiliation: Public Health Department, Ningbo University, People's Republic of China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Shi
authors.affiliation: Affiliated Hospital of Medical School, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Ningbo University, People's Republic of China.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Yu
authors.affiliation: Public Health Department, Ningbo University, People's Republic of China.
authors.forename: Kui
authors.initials: K
authors.lastname: Liu
authors.affiliation: Public Health Department, Ningbo University, People's Republic of China.
authors.forename: Xialu
authors.initials: X
authors.lastname: Lin
authors.affiliation: Public Health Department, Ningbo University, People's Republic of China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.affiliation: Key Laboratory of Magnetic Materials and Devices, Division of Functional Materials and Nano-devices, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo, People's Republic of China.
authors.forename: Cui
authors.initials: C
authors.lastname: Yang
authors.affiliation: Key Laboratory of Magnetic Materials and Devices, Division of Functional Materials and Nano-devices, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo, People's Republic of China.
authors.forename: Aiguo
authors.initials: A
authors.lastname: Wu
authors.affiliation: Public Health Department, Ningbo University, People's Republic of China.
authors.forename: Jinshun
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000818:Animals; D006321:Heart / Q000187:drug effects; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000633:toxicity* / Q000648:ultrastructure; D050997:Nanomedicine; D009532:Nickel / Q000008:administration & dosage* / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000187:drug effects / Q000473:pathology
chemical_list: D009532:Nickel
keywords: acute toxicity; intravenous; nanoparticles; nickel