title: Treadmill gait training improves baroreflex sensitivity in Parkinson's disease.
abstract: BACKGROUND
  Partial weight supported treadmill gait training (PWSTT) is widely used in rehabilitation of gait in patient with Parkinson’s Diseases (PD). However, its effect on blood pressure variability (BPV) and baroreflex sensitivity (BRS) in PD has not been studied.
  
  
  OBJECTIVE
  To evaluate the effect of conventional and treadmill gait training on BPV components and BRS.
  
  
  METHODS
  Sixty patients with idiopathic PD were randomized into three groups. Twenty patients in control group were on only stable medication, 20 patients in conventional gait training (CGT) group (Stable medication with CGT) and 20 patients in PWSTT group (Stable medication with 20 % PWSTT). The CGT and PWSTT sessions were given for 30 min per day, 4 days per week, for 4 weeks (16 sessions). Groups were evaluated in their best ‘ON’ states. The beat-to-beat finger blood pressure (BP) was recorded for 10 min using a Finometer instrument (Finapres Medical Systems, The Netherlands). BPV and BRS results were derived from artifact-free 5-min segments using Nevrocard software.
  
  
  RESULTS
  BRS showed a significant group with time interaction (F = 6.930; p = 0.003). Post-hoc analysis revealed that PWSTT group showed significant improvement in BRS (p < 0.001) after 4 weeks of training. No significant differences found in BPV parameters; systolic BP, diastolic BP, co-variance of systolic BP and low frequency component of systolic BP.
  
  
  CONCLUSIONS
  Four weeks of PWSTT significantly improves BRS in patients with PD. It can be considered as a non-invasive method of influencing BRS for prevention of orthostatic BP fall in patients with PD.
authors.forename: Mohan
authors.initials: M
authors.lastname: Ganesan
authors.forename: Pramod Kumar
authors.initials: PK
authors.lastname: Pal
authors.forename: Anupam
authors.initials: A
authors.lastname: Gupta
authors.forename: Talakad N
authors.initials: TN
authors.lastname: Sathyaprabha
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D005081:Exercise Therapy; D005260:Female; D005684:Gait / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy*; D004856:Postural Balance / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents