title: Effects of a 1-year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children.
abstract: OBJECTIVE
  Exercise improves weight status and metabolism. Irisin, a novel myokine, may be involved in the regulation of metabolic function. The effect of an exercise and dietary lifestyle intervention for 1-year on irisin, adipokines (leptin, adiponectin, resistin) and inflammatory markers (C-reactive protein (CRP), soluble tumor necrosis factor receptor II (sTNFR-II) was evaluated, and predictors of irisin levels were characterized in obese children.
  
  
  METHODS
  Parameters were assessed at baseline and at follow-up for 65 obese children who completed the program (7-18 years, 54%boys). Their relation to weight status and metabolic risk was analyzed.
  
  
  RESULTS
  Anthropometric and metabolic parameters improved after completion of the program. Circulating irisin levels at baseline were 111.0 ± 8.0 ng ml(-1) and increased after the intervention by 12% [6%, 17%], P = 0.00003. There was no evidence for differences in irisin levels between genders and across age. Moreover, changes in irisin did not correlate with those in BMI-SDS, adipokines or inflammatory markers. Leptin decreased after the intervention (Δ5.3 ng ml(-1) , [3.2, 6.3], P = 10(-7) ). Anthropometric measures were significantly associated with leptin and inflammatory markers.
  
  
  CONCLUSIONS
  A 1-year long lifestyle intervention program is associated with improvement in anthropometric and metabolic parameters and leads to an elevation in irisin levels in obese children.
authors.affiliation: Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany.
authors.forename: Susann
authors.initials: S
authors.lastname: Blüher
authors.forename: Grigorios
authors.initials: G
authors.lastname: Panagiotou
authors.forename: David
authors.initials: D
authors.lastname: Petroff
authors.forename: Jana
authors.initials: J
authors.lastname: Markert
authors.forename: Antje
authors.initials: A
authors.lastname: Wagner
authors.forename: Thorsten
authors.initials: T
authors.lastname: Klemm
authors.forename: Andreas
authors.initials: A
authors.lastname: Filippaios
authors.forename: Alexandra
authors.initials: A
authors.lastname: Keller
authors.forename: Christos S
authors.initials: CS
authors.lastname: Mantzoros
mesh_terms: D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D001835:Body Weight / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D015444:Exercise / Q000502:physiology*; D005260:Female; D005353:Fibronectins / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008019:Life Style; D008297:Male; D063766:Pediatric Obesity / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D054392:Adipokines; C577593:FNDC5 protein, human; D005353:Fibronectins; D018836:Inflammation Mediators; D002097:C-Reactive Protein
keywords: KLAKS program; adipocytokines; childhood obesity; irisin; metabolic syndrome