title: [Normal skin biopsy as a tool for extra-cutaneous disorders].
abstract: Biopsies of apparently healthy skin can contribute to the diagnosis of an internal disorder in a patient or in the detection of a potential disease carrier. Herein, we review those diseases for which dermatologists may be asked to perform a biopsy on normal skin where analysis by optical microscopy, immunofluorescence or electronic microscopy may result in diagnosis of an "internal" disease. Diseases for which biopsies are required for cell cultures (e.g. fibroblasts cultures), clonality testing or chromosomal analysis are not discussed here.
authors.affiliation: Department of dermatology, venereology and allergology, skin and allergies hospital, Helsinki University Central Hospital, Meilahdentie 2, PO Box 160, 00029 HUS, Finlande. Electronic address: nicolaskluger@yahoo.fr.
authors.forename: N
authors.initials: N
authors.lastname: Kluger
authors.affiliation: Service d'anatomo-pathologie, hôpital Necker-Enfants-Malades, AP-HP, 149, rue de Sèvres, 75015 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Fraitag
authors.affiliation: Service de dermatologie, CHU, 2, avenue Foch, 29200 Brest, France.
authors.forename: A-M
authors.initials: AM
authors.lastname: Roguedas
authors.affiliation: Service de dermatologie, CHU, 2, avenue Foch, 29200 Brest, France.
authors.forename: L
authors.initials: L
authors.lastname: Misery
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000175:diagnosis / Q000473:pathology; D001706:Biopsy; D046589:CADASIL / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D004916:Erythromelalgia / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D016464:Lysosomal Storage Diseases / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D009394:Nephritis, Hereditary / Q000175:diagnosis / Q000473:pathology; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000473:pathology; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology*; D055815:Young Adult
keywords: Alport syndrome; Amyloidosis; Amylose; CADASIL; Electronic microscopy; Lysosomal storage disease; Maladie lysosomale; Microscopie; Microscopy; Neuropathie des petites fibres; Sjögren's syndrome; Small-fiber neuropathy; Syndrome de Gougerot-Sjögren; Syndrome d’Alport