title: EGF receptor family: twisting targets for improved cancer therapies.
abstract: The epidermal growth factor receptor (EGFR) undergoes a conformational change in response to ligand binding. The ligand-induced changes in cell surface aggregation and mobility have a profound effect on the function of all the family members. Ligand also activates the EGFR intracellular kinase, stimulating proliferation and cell survival. The EGFR family are often activated, overexpressed or mutated in cancer cells and therapeutic drugs (including antibodies) can slow the progress of some cancers. This article provides a brief, annotated summary of the presentations and discussion which occurred at the Epidermal Growth Factor Receptor - Future Directions Conference held in Jerusalem in November 2013.
authors.affiliation: The Walter & Eliza Hall Institute of Medical Research, Burgess Lab Structural Biology , Parkville , Australia .
authors.forename: Antony W
authors.initials: AW
authors.lastname: Burgess
authors.forename: Yoav I
authors.initials: YI
authors.lastname: Henis
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Hynes
authors.forename: Thomas
authors.initials: T
authors.lastname: Jovin
authors.forename: Alexander
authors.initials: A
authors.lastname: Levitzki
authors.forename: Ronit
authors.initials: R
authors.lastname: Pinkas-Kramarski
authors.forename: Yosef
authors.initials: Y
authors.lastname: Yarden
mesh_terms: D000818:Animals; D066246:ErbB Receptors / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D011485:Protein Binding; D011487:Protein Conformation; D021381:Protein Transport; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D066246:ErbB Receptors; D008565:Membrane Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human