title: Whorled Urothelial Cell Carcinoma: A Neglected Variant.
abstract: Twelve cases of urothelial cell papillary carcinoma with a whorled pattern of growth are described. This variant is reported with clinicopathological correlations and immunohistochemical findings. All cases showed this peculiar and distinctive curlicue histological pattern, ranging from 50% to 100% of the neoplastic population. Despite the disordered/turbulent growth pattern, the cytological grade was uniformly low. All the lesions were Ta staged and no patient experienced progression after transurethral resection, while 2 showed clinical recurrences. The immunophenotype (low p53, high p27, low Ki67, and high GATA3) of the cases contributes to define this rare variant as a low-grade tumor.
authors.affiliation: Azienda Ospedaliera Sant'Anna, Como, Italy carlo.patriarca@hsacomo.org.
authors.forename: Carlo
authors.initials: C
authors.lastname: Patriarca
authors.affiliation: Groupe Hospitalier Pitié-Salpétrière, Paris, France.
authors.forename: Eva
authors.initials: E
authors.lastname: Comperat
authors.affiliation: Azienda Ospedaliero-Universitaria S. Luigi Gonzaga, Orbassano, Turin, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Bollito
authors.affiliation: Azienda Ospedaliera Sant'Anna, Como, Italy.
authors.forename: Agazio
authors.initials: A
authors.lastname: Ussia
authors.affiliation: Azienda Ospedaliera Sant'Anna, Como, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scola
authors.affiliation: Azienda Ospedaliera Sant'Anna, Como, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cavallero
authors.affiliation: Azienda Ospedaliera Sant'Anna, Como, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Ferrari
authors.affiliation: Azienda Ospedaliera di Melegnano, Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Giunta
authors.affiliation: Azienda Ospedaliera Sant'Anna, Como, Italy.
authors.forename: Giario
authors.initials: G
authors.lastname: Conti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000473:pathology*; D019459:Urothelium / Q000473:pathology*
keywords: eddies; growth pattern; urothelial carcinoma; variant; whorled