title: Transient erythroblastopenia of childhood is an underdiagnosed and self-limiting disease.
abstract: OBJECTIVE
  Transient erythroblastopenia of childhood (TEC) is an uncommon, benign normocytic anaemia of unknown cause, characterised by reduced or absent mature erythroid precursors in otherwise normocellular bone marrow and a complete spontaneous recovery. We present epidemiological data on paediatric TEC cases in a single centre over 30 years and compare them with published data.
  
  
  METHODS
  In this retrospective study, epidemiological data on children diagnosed with TEC between 1978 and 2008 were collected and compared with published data.
  
  
  RESULTS
  A total of 36 children (median age 19 months, 56% male children) were diagnosed. At presentation, median haemoglobin was 44 g/L with absolute reticulocyte count 0 × 10(9) /L; seventeen (47%) patients were neutropenic and 23 (64%) had platelet counts of more than 400 × 10(9) /L. The majority (78%) presented from 1983 to 1997, and 78% of articles reviewing 10 or more TEC patients were published between 1983 and 1992.
  
  
  CONCLUSIONS
  Transient erythroblastopenia of childhood is now diagnosed less frequently in our institution than in the last two decades. Although the aetiology remains largely unknown, it is possible that changes in causative environmental factors contribute to making TEC a rare disease. Clinicians need to be aware of TEC in order to prevent unnecessary diagnostic and therapeutic measurements.
authors.affiliation: Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Machiel
authors.initials: M
authors.lastname: van den Akker
authors.forename: Yigal
authors.initials: Y
authors.lastname: Dror
authors.forename: Isaac
authors.initials: I
authors.lastname: Odame
mesh_terms: D000367:Age Factors; D000745:Anemia, Hemolytic, Congenital / Q000097:blood / Q000453:epidemiology* / Q000628:therapy; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009864:Ontario / Q000453:epidemiology; D012189:Retrospective Studies; D012737:Sex Factors
keywords: Diamond-Blackfan anaemia; Erythroblastopenia; Pure red cell aplasia; Reticulocytopenia; Transient erythroblastopenia of childhood