title: The IclR-family regulator BapR controls biofilm formation in B. cenocepacia H111.
abstract: In Burkholderia cenocepacia H111, the large surface protein BapA plays a crucial role in the formation of highly structured communities, known as biofilms. We have recently demonstrated that quorum sensing (QS) is necessary for the maximal expression of bapA. In this study we identify BapR, a protein from the IclR family of transcriptional regulators that, in conjunction with QS, controls biofilm formation by affecting the expression of bapA. We present evidence that, in addition to bapA, BapR influences the expression of extracellular proteases, swimming motility and has a profound impact in the incidence of persister cells, making this regulator an interesting target for persister cells and biofilm eradication.
authors.affiliation: Department of Microbiology, Institute of Plant Biology, University of Zurich, Zurich, Switzerland.
authors.forename: Claudio
authors.initials: C
authors.lastname: Aguilar
authors.affiliation: Department of Microbiology, Institute of Plant Biology, University of Zurich, Zurich, Switzerland.
authors.forename: Nadine
authors.initials: N
authors.lastname: Schmid
authors.affiliation: Department of Microbiology, Institute of Plant Biology, University of Zurich, Zurich, Switzerland.
authors.forename: Martina
authors.initials: M
authors.lastname: Lardi
authors.affiliation: Department of Microbiology, Institute of Plant Biology, University of Zurich, Zurich, Switzerland.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Pessi
authors.affiliation: Department of Microbiology, Institute of Plant Biology, University of Zurich, Zurich, Switzerland.
authors.forename: Leo
authors.initials: L
authors.lastname: Eberl
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D018441:Biofilms; D057508:Burkholderia cenocepacia / Q000502:physiology*; D005110:Extracellular Space / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D009154:Mutation; D010447:Peptide Hydrolases / Q000378:metabolism; D053038:Quorum Sensing
chemical_list: D001426:Bacterial Proteins; D010447:Peptide Hydrolases