title: Antimicrobial activities against periodontopathic bacteria of Pittosporum tobira and its active compound.
abstract: The study of medicinal plants for treatment of periodontitis is of great value to establish their efficacy as sources of new antimicrobial drugs. Five hundred and fifty eight Korean local plant extracts were screened for antibacterial activity against representative periodontopathic bacteria such as Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum. Among the various medicinal plants, the alcohol extract of Pittosporum tobira, which significantly exhibited antibacterial effect for all tested strains, showed the highest activity in the antimicrobial assays. NMR analyses revealed that R1-barrigenol, a triterpene sapogenin, was the most effective compound in P. tobira. These results demonstrated that P. tobira possesses antimicrobial properties and would be beneficial for the prevention and treatment of periodontitis.
authors.affiliation: Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Kyunghee Daero 26, Dongdaemungu, Seoul 130-701, Korea.
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Oh
authors.affiliation: Department of Life Science, Gachon University, Seongnam Daero 1342, Seongnam, Gyeonggi-Do 461-701, Korea.
authors.forename: Yong Joon
authors.initials: YJ
authors.lastname: Jeong
authors.affiliation: Department of Life Science, Gachon University, Seongnam Daero 1342, Seongnam, Gyeonggi-Do 461-701, Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Koo
authors.affiliation: Department of Life Science, Gachon University, Seongnam Daero 1342, Seongnam, Gyeonggi-Do 461-701, Korea.
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Park
authors.affiliation: Department of Life Science, Gachon University, Seongnam Daero 1342, Seongnam, Gyeonggi-Do 461-701, Korea. sckang73@gachon.ac.kr.
authors.forename: Se Chan
authors.initials: SC
authors.lastname: Kang
authors.affiliation: Department of Biological & Environmental Science, Dongguk University, Pildongro-1gil 30, Junggu, Seoul 100-715, Korea.
authors.forename: Hoang Viet Bach
authors.initials: HV
authors.lastname: Khoa
authors.affiliation: Department of Biological & Environmental Science, Dongguk University, Pildongro-1gil 30, Junggu, Seoul 100-715, Korea.
authors.forename: Le Ba
authors.initials: le B
authors.lastname: Le
authors.affiliation: Department of Biological & Environmental Science, Dongguk University, Pildongro-1gil 30, Junggu, Seoul 100-715, Korea.
authors.forename: Joon Hyeong
authors.initials: JH
authors.lastname: Cho
authors.affiliation: Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Kyunghee Daero 26, Dongdaemungu, Seoul 130-701, Korea. ljinyong@khu.ac.kr.
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Lee
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy; D002460:Cell Line; D051379:Mice; D008826:Microbial Sensitivity Tests; D010518:Periodontitis / Q000188:drug therapy / Q000382:microbiology*; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010936:Plant Extracts