title: Altered intrinsic functional connectivity of the salience network in childhood absence epilepsy.
abstract: Intrinsic connectivity analysis provides an original way for evaluating functional impairments in epilepsy. Disturbances in the salience network (SN) have been positing an important interplay in disorders of consciousness and attention. This study aims to assess the intrinsic connectivity of the SN in childhood absence epilepsy (CAE). Resting state fMRI was performed in 21 patients with CAE and 21 healthy controls. The SN was extracted using group independent component analysis with dual-regression. Intrinsic functional integration was evaluated through voxelwise comparisons between patients and controls. Patients showed a decreased functional integration of the SN in the right anterior insula, anterior temporoparietal junction, and bilateral dorsolateral frontal cortex and increased connectivity in the anterior and middle cingulate gyrus and caudate nuclei. A leftward lateralization was observed in the anterior insula and anterior temporoparietal junction in CAE. Moreover, the lateralized index in the anterior insula was significantly correlated with the duration of epilepsy. These results support the disturbance of intrinsic activity in the SN which may be linked to the interruption of salient information processing and associated with the attentional dysfunction in CAE. Our findings demonstrate the potential value of intrinsic activity in the SN for the investigation of attention process and may help to better understand the association between intrinsic activity in the SN and consciousness.
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Luo
authors.affiliation: Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.
authors.forename: Tianhua
authors.initials: T
authors.lastname: Yang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Shipeng
authors.initials: S
authors.lastname: Tu
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Jiayan
authors.initials: J
authors.lastname: Deng
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Dongbo
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Neurology, West China Hospital of Sichuan University, Chengdu, China; Department of Neurology, The Affiliated Hospital of Hainan Medical College, China.
authors.forename: Qifu
authors.initials: Q
authors.lastname: Li
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Li
authors.initials: L
authors.lastname: Dong
authors.affiliation: Neuropsychiatry Lab, The Hebrew University of Jerusalem, Jerusalem, Israel.
authors.forename: Ilan
authors.initials: I
authors.lastname: Goldberg
authors.affiliation: Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: An
authors.affiliation: Department of Neurology, West China Hospital of Sichuan University, Chengdu, China. Electronic address: zhoudong66@yahoo.de.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: dyao@uestc.edu.cn.
authors.forename: Dezhong
authors.initials: D
authors.lastname: Yao
mesh_terms: D001288:Attention / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D002648:Child; D004832:Epilepsy, Absence / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000502:physiology*
keywords: Absence seizures; Epilepsy; Functional MRI; Independent component analysis; Intrinsic connectivity network; Salience network