title: Acute treatment with relaxin attenuates the injury/dysfunction induced by renal ischemia/reperfusion injury.
abstract: Although preclinical and clinical studies have demonstrated that relaxin (RLX) ameliorates impaired renal function by exerting antifibrotic and regenerative effects, its role in renal ischemia/reperfusion (I/R) injury has never been investigated. Using a well-known rat model of 1 h bilateral renal artery occlusion followed by 6 h reperfusion, we investigated the effects of human recombinant RLX (5 microg /Kg e.v.) given both at the beginning and after 3 h reperfusion. Serum and urinary indicators of renal injury and dysfunction were measured. Interestingly, administration of the exogenous RLX attenuated all markers of renal injury and dysfunction caused by I/R. Overall, we document here, for the first time, that RLX protects against I/R-induced renal injury and dysfunction. The results of this study offer good perspectives for the clinical potential of RLX in the medical treatment of renal diseases.
authors.forename: Massimo
authors.initials: M
authors.lastname: Collino
authors.forename: Mara
authors.initials: M
authors.lastname: Rogazzoi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pini
authors.forename: Elisa
authors.initials: E
authors.lastname: Benetti
authors.forename: Arianna Carolina
authors.initials: AC
authors.lastname: Rosa
authors.forename: Roberto
authors.initials: R
authors.lastname: Fantozzi
authors.forename: Daniele
authors.initials: D
authors.lastname: Bani
authors.forename: Emanuela
authors.initials: E
authors.lastname: Masini
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012065:Relaxin / Q000494:pharmacology*; D015427:Reperfusion Injury / Q000188:drug therapy*
chemical_list: C095067:RLN1 protein, human; D012065:Relaxin