title: Recent advances in understanding endometrial receptivity: molecular basis and clinical applications.
abstract: Advancement in the field of ART has lead to the possibility of achieving good quality embryos. However, the success rate in ART needs further improvement. This is largely dependent on identifying the receptive endometrium for the successful implantation of embryos as well as modulating the endometrium to the receptive stage. In the last half-a-decade, focus has been shifting toward identifying the receptive endometrium. Here, we summarize different tools explored to identify receptive endometrium from the literature, mainly focusing on the past decade, with the help of PubMed. The quest to identify endometrial receptivity markers has lead to the exploration of morphological features at micro and macro scale levels. A large number of studies at molecular levels have focused on genomic, proteomic and lipidomic targets. Recent development of endometrial receptivity array is a promising diagnostic instrument. However, a noninvasive possibility for the diagnosis of endometrial receptivity would be an ideal tool, which could be used in the clinic to improve the success rate of ART. Improved knowledge on endometrial receptivity will not only help to improve the diagnosis and treatment of infertility but will also give possibilities to develop new contraceptive methods targeting the endometrium.
authors.affiliation: Division of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Carolina
authors.initials: C
authors.lastname: von Grothusen
authors.forename: Sujata
authors.initials: S
authors.lastname: Lalitkumar
authors.forename: Nageswara Rao
authors.initials: NR
authors.lastname: Boggavarapu
authors.forename: Kristina
authors.initials: K
authors.lastname: Gemzell-Danielsson
authors.forename: Parameswaran G
authors.initials: PG
authors.lastname: Lalitkumar
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D030541:Databases, Genetic; D010064:Embryo Implantation / Q000276:immunology*; D004622:Embryo, Mammalian; D004715:Endometriosis / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D004717:Endometrium / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005307:Fertilization in Vitro; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007247:Infertility, Female / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology / Q000517:prevention & control; D008055:Lipids / Q000276:immunology; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology; D040901:Proteomics; D046888:Tissue Array Analysis
chemical_list: D015415:Biomarkers; D008055:Lipids; D035683:MicroRNAs
keywords: Embryo endometrial dialog; endometrial receptivity; implantation; markers of receptive endometrium