title: Gestational thyroid reference intervals in antibody-negative Chinese women.
abstract: OBJECTIVE
  The aim of this study is to establish gestation-specific reference intervals (GRIs) for thyroid function assays in pregnant Chinese women with ARCHITECT and compare them to other GRI studies.
  
  
  METHODS
  Thyroid antibody negative pregnant Chinese women were enrolled and followed to establish GRIs for thyroid function by use of the Abbott ARCHITECT i2000SR analyzer (N=1409). Samples from 360 non-pregnant Chinese women served as controls.
  
  
  RESULTS
  GRIs of thyroid-stimulating hormone, free thyroxine and free triiodothyronine for first trimester pregnancies were 0.16-3.78mIU/L, 10.9-17.7pmol/L and 2.9-5.0pmol/L, respectively. GRIs for second trimester pregnancies were 0.34-3.51mIU/L, 9.3-15.2pmol/L and 2.9-4.6pmol/L. GRIs for third trimester pregnancies were 0.34-4.32mIU/L, 7.9-14.1pmol/L and 2.9-4.5pmol/L.
  
  
  CONCLUSIONS
  Our thyroid GRIs were different from those in other Chinese studies generated on other analyzers, but were similar to a Swiss study using the same analyzer. These data should prove useful for the interpretation of thyroid function assays among pregnant women measured on the Abbott analyzer.
authors.affiliation: Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou 310006, China. Electronic address: merrytwinsister@163.com.
authors.forename: Feng-Xian
authors.initials: FX
authors.lastname: Shen
authors.affiliation: Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou 310006, China. Electronic address: xiezhenwei315@163.com.
authors.forename: Zhen-Wei
authors.initials: ZW
authors.lastname: Xie
authors.affiliation: Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou 310006, China. Electronic address: lusm@zju.edu.cn.
authors.forename: Shi-Ming
authors.initials: SM
authors.lastname: Lu
authors.affiliation: Department of Laboratory Medicine, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore. Electronic address: tarchoon@gmail.com.
authors.forename: Tar-Choon
authors.initials: TC
authors.lastname: Aw
authors.affiliation: Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou 310006, China. Electronic address: mijvbobo@126.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D011262:Pregnancy Trimester, Second / Q000097:blood; D013960:Thyroid Function Tests / Q000379:methods; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D055815:Young Adult
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine
keywords: Pregnancy; Reference interval; Thyroid function assay