title: DNA double-strand break repair in a cellular context.
abstract: Substantial insight into the mechanisms responding to DNA double-strand breaks has been gained from molecular, biochemical and structural approaches. Attention is now focusing on understanding the interplay between the pathways, how they interface through the cell cycle and the communication with other DNA transactions, such as replication and transcription. Understanding these aspects will facilitate an assessment of how cancer cells have modified these processes to achieve unlimited proliferative capacity and adaptability, and pave the way to identify targets suitable for therapy. Here, we briefly overview the processes responding to double-strand breaks and discuss our current understanding of their interplay in a cellular context.
authors.affiliation: Advanced Scientific Research Leaders Development Unit, Gunma University, Maebashi, Gunma, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Shibata
authors.affiliation: Genome Damage and Stability Centre, Life Sciences at University of Sussex, Brighton, UK. Electronic address: p.a.jeggo@sussex.ac.uk.
authors.forename: P A
authors.initials: PA
authors.lastname: Jeggo
mesh_terms: D001260:Ataxia Telangiectasia / Q000235:genetics; D002453:Cell Cycle / Q000502:physiology; D053903:DNA Breaks, Double-Stranded; D059766:DNA End-Joining Repair / Q000502:physiology; D004260:DNA Repair / Q000502:physiology*; D059765:Homologous Recombination; D006801:Humans; D009154:Mutation; D015398:Signal Transduction / Q000502:physiology
keywords: DNA damage response signalling; DNA non-homologous end-joining; DSB repair; homologous recombination; radiation; radiotherapy