title: Microarrays and single molecules: an exciting combination.
abstract: Biomolecules positioned at interfaces have spawned many applications in bioanalysis, biophysics, and cell biology. This Highlight describes recent developments in the research areas of protein and DNA arrays, and single-molecule sensing. We cover the ultrasensitive scanning of conventional microarrays as well as the generation of arrays composed of individual molecules. The combination of these tools has improved the detection limits and the dynamic range of microarray analysis, helped develop powerful single-molecule sequencing approaches, and offered biophysical examination with high throughput and molecular detail. The topic of this Highlight integrates several disciplines and is written for interested chemists, biophysicists and nanotechnologists.
authors.affiliation: Department of Chemistry, Institute for Structural and Molecular Biology, University College London, London WC1H 0AJ, UK. s.howorka@ucl.ac.uk.
authors.forename: Stefan
authors.initials: S
authors.lastname: Howorka
authors.forename: Jan
authors.initials: J
authors.lastname: Hesse
mesh_terms: D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D040081:Protein Array Analysis / Q000379:methods*