title: Sugarcoating ER Stress.
abstract: The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.
authors.affiliation: Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Vincenz
authors.affiliation: Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. Electronic address: uhartl@biochem.mpg.de.
authors.forename: F Ulrich
authors.initials: FU
authors.lastname: Hartl
mesh_terms: D000818:Animals; D053898:Biosynthetic Pathways; D017173:Caenorhabditis elegans / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000378:metabolism*; D006595:Hexosamines / Q000378:metabolism*; D006801:Humans; D008136:Longevity; D008297:Male; D011506:Proteins / Q000378:metabolism*; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors / Q000378:metabolism*; D056811:Unfolded Protein Response
chemical_list: D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins; D006595:Hexosamines; D011506:Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)