title: A review of the predisposing, precipitating and perpetuating factors in Chronic Fatigue Syndrome in children and adolescents.
abstract: Chronic Fatigue Syndrome (CFS) is a condition characterised by severe mental and physical fatigue coupled with profound disability. The purpose of this review was to investigate psychological, social and physiological factors associated with fatigue and disability in CFS in children and adolescents. The review aimed to gain an overview of the strength of evidence for the relationship between these different factors and CFS in young people. Seventy-nine studies met the inclusion criteria and were included in the review. A narrative synthesis of these studies was conducted. The strongest and most consistent finding was that rates of psychiatric co-morbidity, predominantly anxiety and depressive disorders, were higher in young people with CFS compared to healthy controls or illness control groups. Studies suggested that many children and adolescents with CFS reported that their illness began with an infection and there was some objective and prospective evidence to support this. Preliminary evidence suggested a link between CFS and a family history of CFS, high expectations from both the parent and child, personality traits such as conscientiousness and physical illness attributions. The evidence was limited by methodological problems. Few studies were prospective in nature and future research should address this. Clinical implications of the findings are discussed and a hypothesised model of the factors associated with CFS in children and adolescents is presented.
authors.affiliation: Chronic Fatigue Research and Treatment Unit, South London and Maudsley NHS Trust, 1st Floor, Mapother House, De Crespigny Park, Denmark Hill, London SE5 8AZ, UK.
authors.forename: Kate
authors.initials: K
authors.lastname: Lievesley
authors.affiliation: Institute of Psychiatry, Kings College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.
authors.forename: Katharine A
authors.initials: KA
authors.lastname: Rimes
authors.affiliation: Chronic Fatigue Research and Treatment Unit, South London and Maudsley NHS Trust, 1st Floor, Mapother House, De Crespigny Park, Denmark Hill, London SE5 8AZ, UK; Academic Department of Psychological Medicine, 3rd Floor, Weston Education Centre, King's College London, Cutcombe Road, London SE5 9RJ, UK. Electronic address: Trudie.Chalder@kcl.ac.uk.
authors.forename: Trudie
authors.initials: T
authors.lastname: Chalder
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000453:epidemiology / Q000523:psychology; D002648:Child; D015897:Comorbidity; D015673:Fatigue Syndrome, Chronic / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000523:psychology; D010551:Personality; D015995:Prevalence; D012307:Risk Factors; D012649:Self Concept; D012737:Sex Factors
keywords: Chronic Fatigue Syndrome; Review; Young people