title: Role of FDG-PET/CT for monitoring soft tissue tumors.
abstract: The aim of the current study was to evaluate the limitations of 2-deoxy-2-F18-fluoro-D-glucose positron emission tomography combined with computed tomography (FDG-PET/CT) when monitoring soft tissue tumors. The diagnostic criteria of malignancy was defined as the tumor having a maximum standardized uptake value (SUVmax) ≥2.0 and a maximum diameter ≥5 cm as measured using FDG-PET/CT. One-hundred-and-thirteen patients, that were either included in the criteria or not, were compared. In addition, the values of SUVmax of the primary tumor and relapse in 12 patients were evaluated. The Kaplan-Meier analysis demonstrated that patients with tumors measuring ≥5 cm size and ≥2.0 SUVmax were associated with a worse survival rate. Among the 12 patients with relapse, statistical significances were detected in the tumor diameters, however, not in the SUVmax values. Thus, the criteria identified patients that were associated with a poor prognosis, and the SUVmax of distant metastases and local recurrences were identified to be significantly affected by tumor size.
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hoshi
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Oebisu
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Takada
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ieguchi
authors.affiliation: Department of Diagnostic Pathology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Wakasa
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nakamura
keywords: 2-deoxy-2-F18-fluoro-D-glucose positron emission tomography; computed tomography; maximum standardized uptake value; metastasis; prognosis; recurrence; soft tissue tumor