title: [Henoch-Schönlein purpura in the adult].
abstract: Henoch-Schönlein purpura is a systemic vasculitis of the small vessels characterized by perivascular leucocyte infiltrates. It is an immunoglobulin A-related immune complex-mediated disease involving the skin, the joints and the gastrointestinal system. Renal disease may sometimes be associated to these clinical manifestations. Prevalence of the nephritis is highly variable, depending on the series. More rarely, other organs such as the lungs, the heart or the nervous system may be involved. The clinical diagnosis is confirmed by histopathology of the skin (leukocytoclastic vasculitis) and kidney (endo-capillary proliferative glomerulonephritis), showing IgA deposits in these tissues. Short-term prognosis depends on the severity of digestive involvement, but long-term prognosis depends on the renal disease. Recent publications of pediatric and adult series show that the chronic renal failure may progress, sometimes more than ten years after the initial flare. Treatment is usually supportive. The benefit of more specific treatments (corticosteroids or immunosuppressive drugs) in severe visceral forms (usually abdominal or kidney) has not yet been established.
authors.affiliation: Service de néphrologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France; Inserm, U699, faculté Bichat, 75018 Paris, France. Electronic address: evangeline.pillebout@sls.aphp.fr.
authors.forename: E
authors.initials: E
authors.lastname: Pillebout
authors.affiliation: Laboratoire de pathologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France; UMR-S 728, université Paris Diderot, Sorbonne Paris Cité, 75010 Paris, France; Inserm, U728, 75010 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Verine
mesh_terms: D000328:Adult; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D007070:Immunoglobulin A / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011379:Prognosis
chemical_list: D005938:Glucocorticoids; D007070:Immunoglobulin A; D007166:Immunosuppressive Agents
keywords: Glomérulonéphrite; Henoch-Schönlein purpura; IgA; Nephritis; Palpable purpura; Purpura rhumatoïde; Purpura vasculaire; Small-vessel vasculitis; Vascularite des petits vaisseaux