title: Relaxin and the control of primate parturition.
abstract: In primate pregnancy, circulating relaxin, solely a product of the corpus luteum, peaks in the first trimester of pregnancy then declines and levels off for the remainder of pregnancy. Relaxin actions in pregnancy include increasing cervical pro-MMP-1 and pro-MMP-3 and decreasing TIMP-1, changes which soften the cervix. Relaxin, from early pregnancy, increases endometrial natural killer cells, macrophages and neutrophils, blood flow and arterial number. Hyperrelaxinemia correlates with preterm birth.
authors.forename: Gerson
authors.initials: G
authors.lastname: Weiss
mesh_terms: D000818:Animals; D020070:Cervical Ripening / Q000502:physiology*; D003338:Corpus Luteum / Q000378:metabolism*; D005260:Female; D006801:Humans; D008253:Macaca mulatta; D036801:Parturition / Q000502:physiology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011323:Primates; D012065:Relaxin / Q000502:physiology*
chemical_list: C095067:RLN1 protein, human; D012065:Relaxin