title: Fibrin glue-assisted for the treatment of corneal perforations using glycerin-cryopreserved corneal tissue.
abstract: OBJECTIVE
  To evaluate the outcomes and safety of lamellar keratoplasty (LK) assisted by fibrin glue in corneal perforations.
  
  
  METHODS
  Six eyes of 6 patients affected by different corneal pathologies (2 posttraumatic corneal scar and 3 bacterial keratitis) underwent LK procedures by using fibrin glue. The mean corneal perforation diameter was 1.35±0.64mm (range, 0.7-2.5mm), and the greatest diameter of the ulcerative stromal defect was 2.47±0.77mm in average (range, 1.5-3.5mm). The donor corneal lamella diameters were 0.20-mm larger and thicker than the recipient to restore a physiologic corneal thickness and shape: mean donor diameter was 8.34±0.28mm (range, 8.2-8.7mm) and mean thickness was 352±40.27mm (range, 220-400mm). Mean follow-up was 7.33±1.97 months (range, 6-11 months). Postoperatively, the graft status, graft clarity, anterior chamber response, the visual prognosis, intraocular pressures, and postoperative complications were recorded.
  
  
  RESULTS
  All the corneal perforations were successfully healed after the procedure. The best-corrected visual acuity (BCVA) ranged from 20/1 000 to 20/50 in their initial presentation, and from 20/100 to 20/20 in their last visit, showed increase in all the patients. No major complications such as graft dislocation and graft failure were noted. Neovascularization developed in the superficial stroma of donor graft in 1 case. High intraocular pressure developed on day 2 after surgery, while was remained in normal range after application of anti-glaucomatous eyedrops for 1 week in 1 case.
  
  
  CONCLUSIONS
  Fibrin glue-assisted sutureless LK is valuable for maintaining the ocular integrity in the treatment of corneal perforations.
authors.affiliation: Affiliated Xiamen Eye Center of Xiamen University, 336 Xiahe Road, Xiamen 361001, Fujian Province, China.
authors.forename: Nuo
authors.initials: N
authors.lastname: Dong
authors.affiliation: Affiliated Xiamen Eye Center of Xiamen University, 336 Xiahe Road, Xiamen 361001, Fujian Province, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.affiliation: Affiliated Xiamen Eye Center of Xiamen University, 336 Xiahe Road, Xiamen 361001, Fujian Province, China.
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Chen
authors.affiliation: Affiliated Xiamen Eye Center of Xiamen University, 336 Xiahe Road, Xiamen 361001, Fujian Province, China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Qin
authors.affiliation: Affiliated Xiamen Eye Center of Xiamen University, 336 Xiahe Road, Xiamen 361001, Fujian Province, China.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Xue
authors.affiliation: Affiliated Xiamen Eye Center of Xiamen University, 336 Xiahe Road, Xiamen 361001, Fujian Province, China.
authors.forename: Hu-Ping
authors.initials: HP
authors.lastname: Wu
keywords: fibrin glue corneal perforation; lamellar keratoplasty