title: Biology of soft tissue wound healing and regeneration--consensus report of Group 1 of the 10th European Workshop on Periodontology.
abstract: BACKGROUND
  The scope of this consensus was to review the biological processes of soft tissue wound healing in the oral cavity and to histologically evaluate soft tissue healing in clinical and pre-clinical models.
  
  
  OBJECTIVE
  To review the current knowledge regarding the biological processes of soft tissue wound healing at teeth, implants and on the edentulous ridge. Furthermore, to review soft tissue wound healing at these sites, when using barrier membranes, growth and differentiation factors and soft tissue substitutes.
  Searches of the literature with respect to recessions at teeth and soft tissue deficiencies at implants, augmentation of the area of keratinized tissue and soft tissue volume were conducted. The available evidence was collected, categorized and summarized.
  Oral mucosal and skin wound healing follow a similar pattern of the four phases of haemostasis, inflammation, proliferation and maturation/matrix remodelling. The soft connective tissue determines the characteristics of the overlaying oral epithelium. Within 7-14 days, epithelial healing of surgical wounds at teeth is completed. Soft tissue healing following surgery at implants requires 6-8 weeks for maturation. The resulting tissue resembles scar tissue. Well-designed pre-clinical studies providing histological data have been reported describing soft tissue wound healing, when using barrier membranes, growth and differentiation factors and soft tissue substitutes. Few controlled clinical studies with low numbers of patients are available for some of the treatments reviewed at teeth. Whereas, histological new attachment has been demonstrated in pre-clinical studies resulting from some of the treatments reviewed, human histological data commonly report a lack of new attachment but rather long junctional epithelial attachment and connective tissue adhesion. Regarding soft tissue healing at implants human data are very scarce.
  
  
  CONCLUSIONS
  Oral soft tissue healing at teeth, implants and the edentulous ridge follows the same phases as skin wound healing. Histological studies in humans have not reported new attachment formation at teeth for the indications studied. Human histological data of soft tissue wound healing at implants are limited.
  
  
  CONCLUSIONS
  The use of barriers membranes, growth and differentiation factors and soft tissue substitutes for the treatment of localized gingival/mucosal recessions, insufficient amount of keratinized tissue and insufficient soft tissue volume is at a developing stage.
authors.affiliation: University of Zurich, Zurich, Switzerland.
authors.forename: Christoph H F
authors.initials: CH
authors.lastname: Hämmerle
authors.forename: William V
authors.initials: WV
authors.lastname: Giannobile
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use; D015921:Dental Implants; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D007575:Jaw, Edentulous / Q000601:surgery; D008567:Membranes, Artificial; D010510:Periodontal Diseases / Q000601:surgery*; D010519:Periodontium / Q000502:physiology / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*; D012038:Regeneration / Q000502:physiology; D014070:Tooth / Q000601:surgery; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D015921:Dental Implants; D036341:Intercellular Signaling Peptides and Proteins; D008567:Membranes, Artificial
keywords: barrier membranes; growth and differentiation factors; human histology; oral soft tissue; periodontal/peri-implant wound healing; pre-clinical studies; scaffolds; soft tissue substitutes