title: Central neural regulation of brown adipose tissue thermogenesis and energy expenditure.
abstract: Thermogenesis, the production of heat energy, is the specific, neurally regulated, metabolic function of brown adipose tissue (BAT) and contributes to the maintenance of body temperature during cold exposure and to the elevated core temperature during several behavioral states, including wakefulness, the acute phase response (fever), and stress. BAT energy expenditure requires metabolic fuel availability and contributes to energy balance. This review summarizes the functional organization and neurochemical influences within the CNS networks governing the level of BAT sympathetic nerve activity to produce the thermoregulatory and metabolically driven alterations in BAT thermogenesis and energy expenditure that contribute to overall energy homeostasis.
authors.affiliation: Department of Neurological Surgery Oregon Health & Science University Portland, OR, 97239 USA.
authors.forename: Shaun F
authors.initials: SF
authors.lastname: Morrison
authors.affiliation: Department of Neurological Surgery Oregon Health & Science University Portland, OR, 97239 USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Madden
authors.affiliation: Department of Neurological Surgery Oregon Health & Science University Portland, OR, 97239 USA.
authors.forename: Domenico
authors.initials: D
authors.lastname: Tupone
mesh_terms: D002001:Adipose Tissue, Brown / Q000502:physiology*; D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D022722:Thermogenesis / Q000502:physiology*