title: Cholecystokinin: how many functions? Observations in seabreams.
abstract: A short overview on the regional distribution of the gastro-intestinal peptide hormone cholecystokin (CCK) in fish is presented. In particular, the results of molecular and immunological studies on seabreams, Diplodus puntazzo and Diplodus sargus, are reported, which, by demonstrating CCK in the hindgut, open new questions regarding the functional role of this hormone in that part of the intestine. The putative involvement of hindgut CCK in the feedback control of digestive processes was tested by measuring CCK gene and protein expression in fed and fasted fish. The results of this study led to hypothesize different roles for the two CCK isoforms in D. sargus, one of which related to regulation of digestive processes from pyloric caeca through hindgut. On the other hand, a functional role alternative to regulation of digestive processes may be inferred for the other isoform.
authors.affiliation: Istituto per l'Ambiente Marino Costiero, Consiglio Nazionale delle Ricerche, Messina, Italy. Electronic address: valeria.micale@iamc.cnr.it.
authors.forename: Valeria
authors.initials: V
authors.lastname: Micale
authors.affiliation: Department of Biochemical, Physiological and Nutritional Sciences, Section of Medical Chemistry, School of Medicine, University of Messina, Messina, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Campo
authors.affiliation: Department of Biochemical, Physiological and Nutritional Sciences, Section of Medical Chemistry, School of Medicine, University of Messina, Messina, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: D'Ascola
authors.affiliation: School of Veterinary Sciences, University of Messina, Italy.
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Guerrera
authors.affiliation: School of Veterinary Sciences, University of Messina, Italy.
authors.forename: M Beatrice
authors.initials: MB
authors.lastname: Levanti
authors.affiliation: School of Veterinary Sciences, University of Messina, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Germanà
authors.affiliation: School of Veterinary Sciences, University of Messina, Italy; Consorzio Interuniversitario INBB, Roma, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: Muglia
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D021541:Sea Bream / Q000378:metabolism*
chemical_list: D002766:Cholecystokinin
keywords: Cholecystokinin; Diplodus puntazzo; Diplodus sargus; Gut; Seabream