title: Haematological cancer: idelalisib-targeting PI3Kδ in patients with B-cell malignancies.
authors.affiliation: Department of Leukemia, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
authors.forename: Jan A
authors.initials: JA
authors.lastname: Burger
authors.affiliation: Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK.
authors.forename: Klaus
authors.initials: K
authors.lastname: Okkenhaug
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D054405:Chemokine CCL3 / Q000378:metabolism; D058534:Class I Phosphatidylinositol 3-Kinases; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000139:chemically induced; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000201:enzymology; D016393:Lymphoma, B-Cell / Q000188:drug therapy* / Q000201:enzymology; D051379:Mice; D058990:Molecular Targeted Therapy; D009154:Mutation; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011687:Purines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D052999:Quinazolinones / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D015398:Signal Transduction; D016896:Treatment Outcome; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents; D054405:Chemokine CCL3; D058534:Class I Phosphatidylinositol 3-Kinases; D009363:Neoplasm Proteins; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; D011687:Purines; D052999:Quinazolinones; C515429:CCL3 protein, human; C486018:PIK3CD protein, human; C421683:Pik3cd protein, mouse; C552946:idelalisib