title: Embryotoxic and teratogenic effects of norfloxacin in pregnant female albino rats.
abstract: This study was designed to investigate the possible developmental teratogenicity of norfloxacin in rats. Forty pregnant female rats were divided into four equal groups. Group A received norfloxacin in a dose of 500 mg/kg·b·wt/day orally from 6th to 15th day of gestation. Groups B and C received 1000 and 2000 mg/kg·b·wt/day orally for the same period, respectively; Group D behaved as control and received 0.5 mL distilled water orally for the same period. The dams were killed on 20th day of gestation and their fetuses were subjected to morphological, visceral, and skeletal examinations. Norfloxacin significantly decreased the number of viable fetuses, increased the number of resorbed fetuses, and induced retardation in growth of viable fetuses; some visceral and skeletal defects in these fetuses were seen and these effects were dose dependant. Conclusively, norfloxacin caused some fetal defects and abnormalities, so it is advisable to avoid using this drug during pregnancy.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qaliobiya 13736, Egypt.
authors.forename: Mohamed
authors.identifier: 0000-0003-1719-4844
authors.initials: M
authors.lastname: Aboubakr
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qaliobiya 13736, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Elbadawy
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Soliman
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City, Minoufiya 32897, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Hewaity