title: Replication-induced supercoiling: a neglected DNA transaction regulator?
abstract: Dynamic (-) DNA supercoiling generated in the wake of translocating protein complexes is known to occur during transcription. Recent studies indicate that (-) superhelical tension also builds up specifically in the leading duplex during replication. Here, we argue that this unrecognized supercoiling is causally involved in the regulation of key DNA transactions and deserves further consideration.
authors.affiliation: School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
authors.forename: Haojie
authors.initials: H
authors.lastname: Yu
authors.affiliation: School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore. Electronic address: pdroge@ntu.edu.sg.
authors.forename: Peter
authors.initials: P
authors.lastname: Dröge
mesh_terms: D004247:DNA / Q000737:chemistry*; D004261:DNA Replication; D004269:DNA, Bacterial / Q000737:chemistry; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D009690:Nucleic Acid Conformation; D014158:Transcription, Genetic
chemical_list: D004269:DNA, Bacterial; D004247:DNA; D004259:DNA-Directed DNA Polymerase
keywords: DNA polymerase; DNA transactions; dynamic DNA supercoiling; leading strand duplex; parental DNA; protein translocation; replication