title: Regulation of LRP-1 expression: make the point.
abstract: The low-density lipoprotein receptor-related protein-1 (LRP-1) is a membrane receptor displaying both scavenging and signaling functions. The wide variety of extracellular ligands and of cytoplasmic scaffolding and signaling proteins interacting with LRP-1 gives it a major role not only in physiological processes, such as embryogenesis and development, but also in critical pathological situations, including cancer and neurological disorders. In this review, we describe the molecular mechanisms involved at distinct levels in the regulation of LRP-1, from its expression to the proper location and stability at the cell surface.
authors.affiliation: UMR CNRS 7369, unité MEDyC (matrice extracellulaire et dynamique cellulaire), université de Reims-Champagne-Ardenne (URCA), UFR sciences exactes et naturelles, campus Moulin-de-la-Housse, BP 1039, 51687 Reims cedex 2, France.
authors.forename: H
authors.initials: H
authors.lastname: Emonard
authors.affiliation: UMR CNRS 7369, unité MEDyC (matrice extracellulaire et dynamique cellulaire), université de Reims-Champagne-Ardenne (URCA), UFR sciences exactes et naturelles, campus Moulin-de-la-Housse, BP 1039, 51687 Reims cedex 2, France.
authors.forename: L
authors.initials: L
authors.lastname: Théret
authors.affiliation: UMR CNRS 7369, unité MEDyC (matrice extracellulaire et dynamique cellulaire), université de Reims-Champagne-Ardenne (URCA), UFR sciences exactes et naturelles, campus Moulin-de-la-Housse, BP 1039, 51687 Reims cedex 2, France.
authors.forename: A H
authors.initials: AH
authors.lastname: Bennasroune
authors.affiliation: UMR CNRS 7369, unité MEDyC (matrice extracellulaire et dynamique cellulaire), université de Reims-Champagne-Ardenne (URCA), UFR sciences exactes et naturelles, campus Moulin-de-la-Housse, BP 1039, 51687 Reims cedex 2, France. Electronic address: stephane.dedieu@univ-reims.fr.
authors.forename: S
authors.initials: S
authors.lastname: Dedieu
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D060833:Cellular Microenvironment; D018450:Disease Progression; D004705:Endocytosis / Q000502:physiology; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008024:Ligands; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008958:Models, Molecular; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000473:pathology; D010447:Peptide Hydrolases / Q000378:metabolism; D010766:Phosphorylation; D011487:Protein Conformation; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D015398:Signal Transduction / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: C475476:LRP1 protein, human; D008024:Ligands; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D009363:Neoplasm Proteins; D010447:Peptide Hydrolases
keywords: Endocytose; Endocytosis; LRP-1; Protéolyse; Shedding; Signaling; Signalisation