title: Ovarian haemorrhage: a rare presentation and diagnostic dilemma in factor XIII deficiency.
abstract: Factor XIII (FXIII) deficiency is a rare (autosomal recessive) genetic disorder which is associated with delayed bleeding symptoms that occur hour or days after trauma. Spontaneous rupture of visceral organs due to FXIII deficiency is a rare cause of abdominal pain with grave consequences and can be easily confused with other abdominal pathologies because of normal standard coagulation profile in these patients. We report a 15-year-old girl with spontaneous ovarian haemorrhage and splenic haematoma with FXIII deficiency. She had normal coagulation screen along with normal FXIII screen initially on the 5M urea testing which lead to delay in her diagnosis.
authors.forename: Muhammad Matloob
authors.initials: MM
authors.lastname: Alam
authors.forename: Ahmed Raza
authors.initials: AR
authors.lastname: Iftikhar
authors.forename: Naureen
authors.initials: N
authors.lastname: Mushtaq
authors.forename: Zehra
authors.initials: Z
authors.lastname: Fadoo
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005176:Factor XIII / Q000378:metabolism*; D005177:Factor XIII Deficiency / Q000097:blood / Q000150:complications*; D005260:Female; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D010049:Ovarian Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed
chemical_list: D005176:Factor XIII