title: [Potential relevance of microRNAs in the diagnostics of inflammatory bowel diseases].
abstract: Inflammatory bowel diseases are chronic inflammatory disorders characterized by relapses and remissions. Several factors have been suggested to participate in their development, although their detailed pathogenesis still remains largely unknown. MicroRNAs are single strained, non-coding RNAs, consisting of 18-25 nucleotides that regulate gene expression at the posttranscriptional level. Aberrant expression of microRNAs has been found in several malignant tumors. Recently the role of microRNAs in the pathogenesis of inflammatory-autoimmune disorders (such as inflammatory bowel disease) is being intensively investigated. Beside their pathogenic roles, microRNAs can also be exploited as diagnostic markers, especially in cases where the interpretation of histological data is difficult. In this review the authors discuss recent findings in the field of microRNAs in the diagnosis and pathogenesis of inflammatory bowel diseases.
authors.affiliation: Szent Imre Egyetemi Oktatókórház Gasztroenterológia Profil Budapest Tétényi út 12-16. 1115.
authors.forename: Iván
authors.initials: I
authors.lastname: Igaz
authors.affiliation: Szent Imre Egyetemi Oktatókórház Gasztroenterológia Profil Budapest Tétényi út 12-16. 1115.
authors.forename: Mihály
authors.initials: M
authors.lastname: Szőnyi
authors.affiliation: Szent Imre Egyetemi Oktatókórház Gasztroenterológia Profil Budapest Tétényi út 12-16. 1115.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Varga
authors.affiliation: Szent Imre Egyetemi Oktatókórház Gasztroenterológia Profil Budapest Tétényi út 12-16. 1115.
authors.forename: Lajos
authors.initials: L
authors.lastname: Topa
mesh_terms: D015551:Autoimmunity; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000175:diagnosis* / Q000235:genetics* / Q000276:immunology; D035683:MicroRNAs / Q000097:blood / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
keywords: biomarker; gyulladásos bélbetegség; inflammatory bowel disease; microRNA; mikro-RNS