title: Models construction for acetone-butanol-ethanol fermentations with acetate/butyrate consecutively feeding by graph theory.
abstract: Several fermentations with consecutively feeding of acetate/butyrate were conducted in a 7 L fermentor and the results indicated that exogenous acetate/butyrate enhanced solvents productivities by 47.1% and 39.2% respectively, and changed butyrate/acetate ratios greatly. Then extracellular butyrate/acetate ratios were utilized for calculation of acids rates and the results revealed that acetate and butyrate formation pathways were almost blocked by corresponding acids feeding. In addition, models for acetate/butyrate feeding fermentations were constructed by graph theory based on calculation results and relevant reports. Solvents concentrations and butanol/acetone ratios of these fermentations were also calculated and the results of models calculation matched fermentation data accurately which demonstrated that models were constructed in a reasonable way.
authors.affiliation: The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China. Electronic address: lizhigang25@126.com.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Li
authors.affiliation: The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China. Electronic address: lp19890604@163.com.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Shi
authors.affiliation: The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China. Electronic address: lixin084@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
mesh_terms: D000085:Acetates / Q000378:metabolism*; D000096:Acetone / Q000378:metabolism*; D019149:Bioreactors / Q000382:microbiology; D000440:Butanols / Q000378:metabolism*; D002087:Butyrates / Q000378:metabolism*; D046969:Clostridium acetobutylicum / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism*; D005285:Fermentation; D005947:Glucose / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D053858:Metabolic Networks and Pathways; D008962:Models, Theoretical; D012997:Solvents; D013997:Time Factors
chemical_list: D000085:Acetates; D000440:Butanols; D002087:Butyrates; D012997:Solvents; D000096:Acetone; D000431:Ethanol; D005947:Glucose
keywords: Acids feeding; Butyrate/acetate ratio; Graph theory; Model construction; Solvents productivities