title: Lack of association between a common polymorphism of the endothelial lipase gene and early-onset coronary artery disease in a Chinese Han population.
abstract: A growing body of evidence suggests that the 584C/T polymorphism in the endothelial lipase (EL) gene contributes to the process of coronary artery disease (CAD). The present study aimed to reveal the potential relationship between the EL 584C/T gene polymorphism and early-onset CAD, CAD severity, and lipid levels in a Chinese Han population. Participants comprised 135 early-onset CAD patients and 166 controls. EL 584C/T genotypic and allelic frequencies were detected by PCR. The frequencies of the CC, CT, and TT genotypes were 58.4, 38.6, and 3.0%, respectively, within the control group, and 62.2, 33.3, and 4.5%, respectively, in the early-onset CAD group. There was no significant difference in the frequency of CC genotype and T allele carriers between early-onset CAD patients and controls. The frequency of the T allele was 22.3% in the control group and 21.1% in the early-onset CAD group. The T allele frequency of the variant was not significantly different between the two groups (P = 0.766), even after adjustments for age, gender, smoking status, hypertension, DM, and lipids were made. There was also no significant association between the genotype and the severity of CAD (P = 0.596). Furthermore, there was no correlation between the genotype and lipid levels or their ratios in both groups. The EL 584C/T gene polymorphism, therefore, was not associated with early-onset CAD or the severity of CAD in this Chinese Han population, suggesting that this variant is not always involved in the pathogenesis of early-onset CAD.
authors.affiliation: Department of Cardiology, Wujin hospital, Jiangsu University, Changzhou, Jiangsu Province, China cgj982@126.com.
authors.forename: G J
authors.initials: GJ
authors.lastname: Cai
authors.affiliation: Department of Cardiology, Wujin hospital, Jiangsu University, Changzhou, Jiangsu Province, China.
authors.forename: G P
authors.initials: GP
authors.lastname: He
authors.affiliation: Department of Pediatrics, NO.2 Hospital of Changzhou, Jiangsu, China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Huang
authors.affiliation: Department of Central lab, Wujin hospital, Jiangsu University, Changzhou, Jiangsu Province, China.
authors.forename: C P
authors.initials: CP
authors.lastname: Qi
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D003596:Cytosine / Q000378:metabolism*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008049:Lipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014443:Tyrosine / Q000378:metabolism*
chemical_list: D014443:Tyrosine; D003596:Cytosine; C410382:LIPG protein, human; D008049:Lipase