title: Synthesis, characterization, in vitro anti-proliferative and hemolytic activity of hydroxyapatite.
abstract: Hydroxyapatite (Ca10(PO4)6(OH)2, HAP) nanoparticles are widely used in several biomedical applications due to its compositional similarities to bone mineral, excellent biocompatibility and bioactivity, osteoconductivity. In this present investigation, HAP nanoparticles synthesized by precipitation technique using calcium nitrate and di-ammonium phosphate. The crystalline nature and the functional group analysis are confirmed using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Fourier transform Raman spectroscopy (FT-Raman) respectively. The morphological observations are ascertained from field emission electron scanning electron microscope (FE-SEM) and transmission electron microscope (TEM). In vitro anti-proliferative and hemolytic activities are carried out on the synthesized HAP samples and the studies reveals that HAP have mild activity against erythrocytes.
authors.affiliation: School of Advanced Sciences, VIT University, Vellore 632014, Tamil Nadu, India.
authors.forename: R
authors.initials: R
authors.lastname: Palanivelu
authors.affiliation: School of Advanced Sciences, VIT University, Vellore 632014, Tamil Nadu, India. Electronic address: arubankumarvit@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Ruban Kumar
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D017886:Durapatite / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004912:Erythrocytes / Q000737:chemistry*; D006461:Hemolysis / Q000187:drug effects*; D053878:Hemolytic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D053878:Hemolytic Agents; D017886:Durapatite
keywords: Biocompatibility; FT-Raman; Hemolytic activity; TEM