title: Intravascular optical-resolution photoacoustic tomography with a 1.1 mm diameter catheter.
abstract: Photoacoustic imaging is an emerging technology that can provide anatomic, functional, and molecular information about biological tissue. Intravascular spectroscopic and molecular photoacoustic imaging can potentially improve the identification of atherosclerotic plaque composition, the detection of inflammation, and ultimately the risk stratification of atherosclerosis. In this study, a first-of-its-kind intravascular optical-resolution photoacoustic tomography (OR-PAT) system with a 1.1 mm diameter catheter is developed, offering optical-diffraction limited transverse resolution as fine as 19.6 μm, ∼ 10-fold finer than that of conventional intravascular photoacoustic and ultrasonic imaging. To offer complementary imaging information and depth, the system also acquires co-registered intravascular ultrasound images in parallel. Imaging of an iliac stent and a lipid phantom shows that the high resolution and contrast of OR-PAT can enable improved stent implantation guidance and lipid identification. In the future, these capabilities may ultimately improve the diagnosis and interventional treatment of vulnerable atherosclerotic plaques, which are prone to cause thrombotic complications such as myocardial infarction and stroke.
authors.affiliation: Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Bai
authors.affiliation: Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Gong
authors.affiliation: Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
authors.forename: William
authors.initials: W
authors.lastname: Hau
authors.affiliation: Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: Riqiang
authors.initials: R
authors.lastname: Lin
authors.affiliation: Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: Jiaxiang
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; Beijing Center for Mathematics and Information Interdisciplinary Sciences (BCMIIS), Beijing, China.
authors.forename: Chengbo
authors.initials: C
authors.lastname: Liu
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Zeng
authors.affiliation: Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zou
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; Beijing Center for Mathematics and Information Interdisciplinary Sciences (BCMIIS), Beijing, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Song
mesh_terms: D050197:Atherosclerosis / Q000175:diagnosis; D002318:Cardiovascular Diseases / Q000175:diagnosis; D006801:Humans; D061088:Photoacoustic Techniques / Q000295:instrumentation / Q000379:methods*; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods; D062666:Vascular Access Devices