title: Nutrition: the future of melanoma prevention?
abstract: BACKGROUND
  Melanoma is one of the deadliest forms of skin cancer, having a high metastatic potential and afflicting all age groups. The need for successful preventative measures is particularly urgent as metastatic melanoma is largely incurable. The beneficial role of nutrition and other natural compounds in the prevention and treatment of melanoma has been clearly demonstrated in the past, and is an exciting source for potential therapies in the future.
  
  
  OBJECTIVE
  We sought to review updates in the current literature regarding new developments in the relationship between nutrition and melanoma risk and treatment.
  
  
  METHODS
  Articles in the public domain regarding the impact of diet, grape seed proanthocyanidins, selenium, vitamin D, vitamin E, epigallocatechin-3-gallate, resveratrol, rosmarinic acid, lycopene, and fig latex on melanoma were included.
  
  
  RESULTS
  Grape seed proanthocyanidins, epigallocatechin-3-gallate, resveratrol, rosmarinic acid, lycopene, and fig latex have demonstrated clear anticancer effects toward melanoma. The roles of selenium, vitamin D, and vitamin E, however, have been more controversial.
  
  
  CONCLUSIONS
  None.
  
  
  CONCLUSIONS
  The role of natural compounds in the future of melanoma prevention and treatment is promising and one that is worthy of further exploration.
authors.affiliation: Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California.
authors.forename: Lana X
authors.initials: LX
authors.lastname: Tong
authors.affiliation: Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California. Electronic address: lcyoung@mednet.ucla.edu.
authors.forename: Lorraine C
authors.initials: LC
authors.lastname: Young
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D002338:Carotenoids / Q000627:therapeutic use; D002392:Catechin / Q000031:analogs & derivatives / Q000627:therapeutic use; D004032:Diet; D056604:Grape Seed Extract; D006801:Humans; D000077276:Lycopene; D008545:Melanoma / Q000517:prevention & control*; D018673:Nutrition Policy; D044945:Proanthocyanidins; D000077185:Resveratrol; D012643:Selenium / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000517:prevention & control*; D013267:Stilbenes / Q000627:therapeutic use; D014807:Vitamin D / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D056604:Grape Seed Extract; C511402:Grape Seed Proanthocyanidins; D044945:Proanthocyanidins; D013267:Stilbenes; D014807:Vitamin D; D014810:Vitamin E; D002338:Carotenoids; D002392:Catechin; C045651:epigallocatechin gallate; D012643:Selenium; D000077185:Resveratrol; D000077276:Lycopene
keywords: melanoma; nutrition; prevention; resveratrol; skin cancer; vitamins