title: Engineered alternative skin for partial and full-thickness burns.
abstract: Engineered alternative skin in all its forms and shapes serve to provide temporary or permanent wound closure such as in the case of partial and full-thickness burns. The need for collagen-based regeneration templates is motivated by the fact that dermal regeneration of full-thickness injuries does not occur spontaneously and is inundated by contraction and scarring. Partial-thickness burns in turn can regress as a result of infection and improper treatment and require appropriate treatment. Nylon-silicone laminates such as Biobrane(®), and more recently AWBAT(®), address this by serving as a temporary barrier. Enhanced collagen-based scaffolds today, although not perfect, remain invaluable. Our initial approach was to characterize the design considerations and explore the use of collagen in the fabrication of a dermal regeneration matrix and a silicone-nylon bilaminate. Here we expand our initial research on scaffold fabrication and explore possible strategies to improve the outcome of collagen-scaffold medicated wound healing.
authors.affiliation: Lancaster Medical School; Faculty of Health and Medicine; Lancaster University; Lancaster, UK.
authors.forename: Quenton
authors.initials: Q
authors.lastname: Wessels
mesh_terms: D002056:Burns / Q000473:pathology / Q000628:therapy*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry* / Q000648:ultrastructure; D005109:Extracellular Matrix / Q000737:chemistry / Q000648:ultrastructure; D005612:Freeze Drying; D005615:Freezing; D006801:Humans; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D012867:Skin / Q000737:chemistry / Q000648:ultrastructure; D017768:Skin, Artificial; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014945:Wound Healing / Q000502:physiology
chemical_list: C042816:Biobrane; D020099:Coated Materials, Biocompatible; D003094:Collagen
keywords: alternative skin; collagen-based scaffolds; full-thickness burns; partial-thickness burns; regeneration matrix