title: OncomiRDB: a database for the experimentally verified oncogenic and tumor-suppressive microRNAs.
abstract: CONCLUSIONS
  MicroRNAs (miRNAs), a class of small regulatory RNAs, play important roles in cancer initiation, progression and therapy. MiRNAs are found to regulate diverse cancer-related processes by targeting a large set of oncogenic and tumor-suppressive genes. To establish a high-confidence reference resource for studying the miRNA-regulated target genes and cellular processes in cancer, we manually curated 2259 entries of cancer-related miRNA regulations with direct experimental evidence from ∼9000 abstracts, covering more than 300 miRNAs and 829 target genes across 25 cancer tissues. A web-based portal named oncomiRDB, which provides both graphical and text-based interfaces, was developed for easily browsing and searching all the annotations. It should be a useful resource for both the computational analysis and experimental study on miRNA regulatory networks and functions in cancer.
  
  
  METHODS
  http://bioinfo.au.tsinghua.edu.cn/oncomirdb/
  
  
  BACKGROUND
  jgu@tsinghua.edu.cn
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: MOE Key Laboratory of Bioinformatics, TNLIST Bioinformatics Division / Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing 100084, China.
authors.forename: Dongfang
authors.initials: D
authors.lastname: Wang
authors.affiliation: MOE Key Laboratory of Bioinformatics, TNLIST Bioinformatics Division / Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing 100084, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Gu
authors.affiliation: MOE Key Laboratory of Bioinformatics, TNLIST Bioinformatics Division / Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing 100084, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: MOE Key Laboratory of Bioinformatics, TNLIST Bioinformatics Division / Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing 100084, China.
authors.forename: Zijian
authors.initials: Z
authors.lastname: Ding
mesh_terms: D030561:Databases, Nucleic Acid; D053263:Gene Regulatory Networks; D006801:Humans; D020407:Internet; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D009857:Oncogenes / Q000235:genetics*; D014584:User-Computer Interface
chemical_list: D035683:MicroRNAs