title: Denigrins A-C: new antitubercular 3,4-diarylpyrrole alkaloids from Dendrilla nigra.
abstract: Chemical diversity is vital to antitubercular drug discovery as it ensures a novel bioactivity profile. Marine sponges have so far provided more than 1000 new bioactive molecules. Ethyl acetate extract of the marine sponge Dendrilla nigra on bioactivity-guided screening yielded three new compounds denigrins A-C, with potent antitubercular activity. Spectral and chemical analyses confirmed that these three compounds belong to the 3,4-diaryl pyrrole alkaloid category. The presence of monohydroxy substitution on benzene rings is not very common in lamellarin and related 3,4-diaryl pyrrole alkaloids isolated from marine invertebrates. Among these, denigrin C showed highest potency (minimum inhibitory concentration 4 μg/mL) against Mycobacterium tuberculosis H37Rv.
authors.affiliation: a College of Pharmaceutical Sciences, Andhra University , Visakhapatnam 530003 , Andhra Pradesh , India.
authors.forename: Muthyala
authors.initials: M
authors.lastname: Murali Krishna Kumar
authors.forename: Jarpula
authors.initials: J
authors.lastname: Devilal Naik
authors.forename: Kancherla
authors.initials: K
authors.lastname: Satyavathi
authors.forename: Hechhu
authors.initials: H
authors.lastname: Ramana
authors.forename: Pemmadi
authors.initials: P
authors.lastname: Raghuveer Varma
authors.forename: Kurre
authors.initials: K
authors.lastname: Purna Nagasree
authors.forename: Desaraju
authors.initials: D
authors.lastname: Smitha
authors.forename: Desaraju
authors.initials: D
authors.lastname: Venkata Rao
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007194:India; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D011758:Pyrroles; C000592530:denigrin A; C000592531:denigrin B; C000592532:denigrin C
keywords: 3,4-diarylpyrrole alkaloids; Dendrilla nigra; antitubercular; marine sponge