title: Prognostic significance of plasma copeptin detection compared with multiple biomarkers in intracerebral hemorrhage.
abstract: BACKGROUND
  Higher plasma copeptin concentrations have been associated with poor clinical outcomes after intracerebral hemorrhage. This study was designed to compare plasma concentrations of copeptin and other biomarkers like myelin basic protein, glial fibrillary astrocyte protein, S100B, neuron-specific enolase, phosphorylated axonal neurofilament subunit H, tau and ubiquitin carboxyl-terminal hydrolase L1 for analysis of their prognostic prediction.
  
  
  METHODS
  We measured plasma concentrations of these biomarkers in 118 healthy controls and in 118 acute patients with a comparison analysis for their prediction of 6-month mortality and unfavorable outcome (modified Rankin Scale score>2).
  
  
  RESULTS
  Plasma concentrations of these biomarkers were statistically significantly higher in all patients than in healthy controls, in non-survivors than in survivors and in patients with unfavorable outcome than with favorable outcome. Areas under receiver operating characteristic curves of plasma concentrations of these biomarkers were similar to those of the National Institute of Health Stroke Scale score for prognostic prediction. Plasma copeptin concentration statistically significantly improved the prognostic predictive value of the National Institute of Health Stroke Scale score, but other biomarkers did not.
  
  
  CONCLUSIONS
  Copeptin may help in the prediction of long-term clinical outcomes after intracerebral hemorrhage.
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, The Affiliated Zhongda Hospital of Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China.
authors.forename: Wen-Hong
authors.initials: WH
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China. Electronic address: dxqhyy@163.com.
authors.forename: Xiao-Qiao
authors.initials: XQ
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Du
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Ding-Bo
authors.initials: DB
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Yong-Feng
authors.initials: YF
authors.lastname: Shen
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Zu-Yong
authors.initials: ZY
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Zhi-Hao
authors.initials: ZH
authors.lastname: Che
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Qun-Jie
authors.initials: QJ
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Yuan-Feng
authors.initials: YF
authors.lastname: Du
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D005260:Female; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; C048197:copeptins
keywords: Biomarkers; Copeptin; Intracerebral hemorrhage; Prognosis