title: Baseline predictors of central aortic blood pressure: a PEAR substudy.
abstract: Elevated central systolic blood pressure (BP) increases the risk of cardiovascular events and appears superior to peripheral BP for long term risk prediction. The objective of this study was to identify demographic and clinical factors associated with central pressures in patients with uncomplicated hypertension. We prospectively examined peripheral BP, central aortic BP, and arterial wall properties and wave reflection in 57 subjects with uncomplicated essential hypertension in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) Study. Significant predictors of central SBP included height, smoking status, heart rate (HR), and peripheral systolic BP (SBP), while central diastolic BP (DBP) was explained by peripheral DBP and HR. These variables accounted for nearly all of the variability in central SBP and central DBP (R(2) = 0.94 and R(2) = 0.98, respectively). Central pulse pressure variability was largely explained by gender, ex-smoking status, HR, peripheral SBP, and peripheral DBP (R(2) = 0.94). Central augmented pressure had a direct relationship with smoking status, peripheral SBP, and duration of hypertension, whereas it was indirectly related to height, HR, and peripheral DBP. Easily obtainable demographic and clinical factors are associated with central pressures in essential hypertensive persons. These relationships should be considered in future studies to improve assessment of BP to reduce cardiovascular risk and mortality.
authors.affiliation: Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA. Electronic address: rebecca.rosenwasser@gmail.com.
authors.forename: Rebecca F
authors.initials: RF
authors.lastname: Rosenwasser
authors.affiliation: Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA.
authors.forename: Niren K
authors.initials: NK
authors.lastname: Shah
authors.affiliation: Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Smith
authors.affiliation: Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA; Division of Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Xuerong
authors.initials: X
authors.lastname: Wen
authors.affiliation: Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gong
authors.affiliation: Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA; Division of Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: John G
authors.initials: JG
authors.lastname: Gums
authors.affiliation: Division of Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA; Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Wilmer W
authors.initials: WW
authors.lastname: Nichols
authors.affiliation: The Renal Division, Department of Medicine, Emory University, Atlanta, GA, USA.
authors.forename: Arlene B
authors.initials: AB
authors.lastname: Chapman
authors.affiliation: School of Public Health, Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Boerwinkle
authors.affiliation: Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA; Division of Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Johnson
authors.affiliation: Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA; Division of Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Epstein
mesh_terms: D000293:Adolescent; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001011:Aorta / Q000503:physiopathology*; D062186:Arterial Pressure / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D016896:Treatment Outcome; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents
keywords: Hypertension; applanation tonometry; arterial pressure; blood pressure; cardiovascular disease; pulse wave analysis; vascular stiffness