title: The effect of a hydro-alcoholic extract of olive fruit on reproductive argons in male sprague-dawley rat.
abstract: BACKGROUND
  Olive (Olea europea), from the Oleaceae family, is known as a phytoestrogen plant compound, containing Lignans and phenoliccompounds. Some studies have shown phytoestrogens to have spermatogenesis-decreasing effects.
  
  
  OBJECTIVE
  The present study investigated the effects of a hydro-alcoholic extract of olive fruit on reproductive argons in male rats.
  
  
  METHODS
  The hydro-alcoholic olive (Olea europaea) extract was given orally to three experimental groups of rats in 50, 150, and 450 mg/kg in 48 days. The vehicle group was fed with normal saline and nothing was given to the control group (each group with 8 rats). After 49 days reproductive indicators i.e., sperm count, sperm motility, the weight of prostate, testis, epididymis, and seminal vesicle were measured.
  
  
  RESULTS
  The results showed a significant decrease in the weights of the left testicle, seminal vesicle, testosterone hormone, sperm count and sperm motility but there was no significant difference with regard to the weights of prostate and epididymis, and estradiol hormone.
  
  
  CONCLUSIONS
  This study suggests that olive extract may have deleterious effects on fertility factors; therefore, after further studies, it may be used as a contraceptive in males.
authors.affiliation: Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Najafizadeh
authors.affiliation: Histomorphometry and Stereology Research Center, Department of Anatomy, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Dehghani
authors.affiliation: Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran. ; Medicinal and Natural Products Chemistry Research Center, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Panjeh Shahin
authors.affiliation: Medicinal and Natural Products Chemistry Research Center, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Sommaye
authors.initials: S
authors.lastname: Hamzei Taj
keywords: Infertility; Olea Europaea; Phytoestrogens; Spermatogenesis