title: [Severe human parechovirus-3 sepsis in a 6-week-old infant].
abstract: Febrile infants under 3 months of age are often treated with broad-spectrum intravenous antibiotics while awaiting culture results, to prevent mother-to-child bacterial infections. Human parechoviruses (HPeV) have recently been described as etiologic agents of meningitis and severe sepsis in neonates and young infants. They are rarely investigated and are therefore probably underestimated. They cause acute clinical symptoms that can incorrectly suggest a bacterial infection. In the present case, a 6-week-old infant infected with HPeV developed severe sepsis, complicated by hepatic cytolysis, meningitis, acute renal failure, and mild hemophagocytic lymphohistiocytosis. HPeV type 3 was found by routine specific RT-PCR in cerebrospinal fluid, stools, and plasma. The outcome was spontaneously favorable after 4 days. Early diagnosis of the HPeV infection by routine specific RT-PCR reduces unnecessary antibiotic use and extended hospitalization in febrile young infants.
authors.affiliation: Service de pédiatrie et néonatologie, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France. Electronic address: vincent_ollier@yahoo.fr.
authors.forename: V
authors.initials: V
authors.lastname: Ollier
authors.affiliation: Service de microbiologie, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: E
authors.initials: E
authors.lastname: Farfour
authors.affiliation: Service de pédiatrie et néonatologie, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: O
authors.initials: O
authors.lastname: Charara
authors.affiliation: Service de microbiologie, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: S
authors.initials: S
authors.lastname: Marque Juillet
authors.affiliation: Laboratoire de virologie, centre de biologie, centre national de référence des entérovirus et paréchovirus, CHU de Clermont-Ferrand, 63003 Clermont-Ferrand, France.
authors.forename: A
authors.initials: A
authors.lastname: Mirand
authors.affiliation: Service de pédiatrie générale, hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75015 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Chalouhi
authors.affiliation: Service de pédiatrie et néonatologie, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: P
authors.initials: P
authors.lastname: Foucaud
mesh_terms: D058186:Acute Kidney Injury / Q000821:virology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002439:Cefotaxime / Q000627:therapeutic use; D016971:Citrobacter freundii / Q000302:isolation & purification; D004359:Drug Therapy, Combination; D042241:Early Diagnosis; D004756:Enterobacteriaceae Infections / Q000150:complications; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D008587:Meningitis, Viral / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D030061:Parechovirus / Q000302:isolation & purification*; D010850:Picornaviridae Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014766:Viremia / Q000175:diagnosis* / Q000821:virology
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002439:Cefotaxime