title: Nodular lymphocyte predominant hodgkin lymphoma: biology, diagnosis and treatment.
abstract: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an uncommon variant of classical Hodgkin lymphoma. It is characterized histologically by presence of lymphohistiocytic cells which have B-cell phenotype, are positive for CD19, CD20, CD45, CD79a, BOB.1, Oct.2, and negative for CD15 and CD30. Patients often present with early stage of disease and do not have classical B symptoms. The clinical behavior appears to mimic that of an indolent non-Hodgkin lymphoma more than that of classical Hodgkin disease. The purpose of the present report is to define the biology of NLPHL, review its clinical presentation, and summarize the available clinical data regarding treatment.
authors.affiliation: Department of Hematology and Oncology, St Luke's Roosevelt Hospital Center, New York, NY; Mt Sinai Health System. Electronic address: agoel@chpnet.org.
authors.forename: Anupama
authors.initials: A
authors.lastname: Goel
authors.affiliation: Department of Hematology and Oncology, St Luke's Roosevelt Hospital Center, New York, NY; Mt Sinai Health System.
authors.forename: Wen
authors.initials: W
authors.lastname: Fan
authors.affiliation: Department of Hematology and Oncology, St Luke's Roosevelt Hospital Center, New York, NY.
authors.forename: Amit A
authors.initials: AA
authors.lastname: Patel
authors.affiliation: Department of Hematology and Oncology, St Luke's Roosevelt Hospital Center, New York, NY.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Devabhaktuni
authors.affiliation: Department of Hematology and Oncology, St Luke's Roosevelt Hospital Center, New York, NY; Mt Sinai Health System.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Grossbard
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D006801:Humans; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000209:etiology; D010641:Phenotype; D012008:Recurrence
keywords: Hodgkin lymphoma; LP cell; NLPHL; Popcorn cell; Reed Sternberg cells