title: The DRD2 rs1800497 polymorphism increase the risk of mood disorder: evidence from an update meta-analysis.
abstract: BACKGROUND
  Growing studies have revealed the association between rs1800497 polymorphism in the dopamine receptor D2 (DRD2) and susceptibility to mood disorder (MD). However, the results remained inconsistent.
  
  
  METHODS
  To assess the effect of DRD2 rs1800497 polymorphism on MD. We performed a meta-analysis based on eight case-control studies, including a total of 2097 MD cases and 1681 controls. Summary odds ratios (OR) and corresponding 95% confidence intervals (CIs) for DRD2 rs1800497 polymorphism and MD risk were estimated.
  
  
  RESULTS
  Our meta-analysis indicated that DRD2 rs1800497 was associated with an increased MD risk, especially in Asians. Moreover, in the subgroup analysis by the type of MD, DRD2 rs1800497 polymorphism was observed to increase risk in BP.
  
  
  CONCLUSIONS
  The results should be treated with caution for lacking of data to perform gene-gene and gene-environment interaction.
  
  
  CONCLUSIONS
  Our results indicated that polymorphism in DRD2 rs1800497 may play a role in development of MD.
authors.affiliation: Department of Pathology and Pathophysiology, Cheng Du Medical College, Chengdu 610500, China. Electronic address: zhangls2012@163.com.
authors.forename: LuShun
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Chongqing Three Gorges Medical College, Chongqing 404120, China. Electronic address: huling0511@126.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Hu
authors.affiliation: Basic Medical College, Cheng Du Medical College, Chengdu 610500, China. Electronic address: bluesky918@aliyun.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pathology, First Hospital of Lanzhou University, Lanzhou 730000, China. Electronic address: bigzebrafish@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The Cadre Ward Fourth Ward, People׳s Liberation Army General Hospital of Chengdu Military Region, Chengdu 610083, China. Electronic address: softwind123@163.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D019964:Mood Disorders / Q000235:genetics*; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D018570:Risk Assessment
chemical_list: D017448:Receptors, Dopamine D2
keywords: Dopamine receptor D2; Meta-analysis; Mood disorder; Polymorphism; Rs1800497; Taq1A