title: Effects of polyphenol-rich chokeberry juice on antioxidant/pro-oxidant status in healthy subjects.
abstract: Berry fruits are a rich source of polyphenols, especially anthocyanins: well-known potent anti-oxidant phytochemicals. The purpose of this study was to evaluate beneficial effects of long-term consumption of polyphenol-rich organic chokeberry juice on different markers of antioxidant/pro-oxidant status in healthy female volunteers. Twenty-nine women, aged 25-49, were included in the study. Serological markers of oxidative stress and antioxidant defence, blood pressure, routine biochemical, and anthropometric parameters were analyzed at baseline and after twelve weeks of regular chokeberry juice consumption. Significant decrease in thiobarbituric acid-reactive substances level (TBARS; P<.001) and pro-oxidant-antioxidant balance (PAB; P<.05), as well as increase in paroxonase-1 activity toward diazoxon (P<.01) were found. Total oxidative status and sulphydryl groups levels were not significantly influenced by the intervention. Anthropometric, biochemical parameters, and blood pressure values were within the referent values for all subjects and were not influenced by the chokeberry juice consumption. However, we found positive correlation between age, body mass index, waist circumference, body fat percent, blood pressure, and analyzed marker of lipid peroxidation, which was influenced by the consumption. In conclusion, the fine modulation of several antioxidant/pro-oxidant status biomarkers observed in healthy subjects indicates putative prophylactic effects of polyphenol-rich chokeberry juice and supports its importance as part of an optimal diet.
authors.affiliation: 1 Center of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade , Belgrade, Serbia .
authors.forename: Nevena
authors.initials: N
authors.lastname: Kardum
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Konić-Ristić
authors.forename: Katarina
authors.initials: K
authors.lastname: Savikin
authors.forename: Slavica
authors.initials: S
authors.lastname: Spasić
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Stefanović
authors.forename: Jasmina
authors.initials: J
authors.lastname: Ivanišević
authors.forename: Milica
authors.initials: M
authors.lastname: Miljković
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001628:Beverages / Q000032:analysis*; D001794:Blood Pressure; D005260:Female; D058870:Food, Organic / Q000032:analysis; D005638:Fruit / Q000378:metabolism; D064368:Healthy Volunteers; D006801:Humans; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism*; D018384:Oxidative Stress; D059808:Polyphenols / Q000378:metabolism*; D027861:Prunus / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016877:Oxidants; D059808:Polyphenols; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances
keywords: TBARS; antioxidant; chokeberry; polyphenol; women