title: Laryngeal preservation in stage III/IV resectable laryngo-hypopharyngeal squamous cell carcinoma following concurrent chemoradiotherapy with capecitabine/cisplatin.
abstract: Concurrent chemoradiotherapy has become the standard of care for advanced head and neck cancers in organ preservation strategies. However, the optimal regimen for concurrent chemoradiotherapy to maximise treatment response and minimise toxicity has not been determined. The purpose of the present clinical study was to review our experience with concurrent chemoradiotherapy by using the capecitabine and cisplatin (XP) regimen with the aim of organ preservation in patients with locoregionally advanced laryngo-hypopharyngeal squamous cell carcinoma (LHSCC). Thirty-one patients with stage III/IV resectable LHSCC treated with concurrent chemoradiotherapy using the XP regimen were enrolled in the present study. The patients fulfilled the criteria for total laryngectomy when surgery was selected. The primary endpoint of this study was disease-free survival with a functional larynx, which was indicated by the following conditions: survival, disease-free status at all sites and retention of a functional larynx. Following concurrent chemoradiotherapy, 23 patients (74.2%) exhibited complete response (CR) at the primary site and 18 (69.2%) exhibited CR at the lymph nodes. CR at the primary site and lymph nodes was identified in 19 patients (61.3%). The Kaplan-Meier 2- and 3-year cumulative disease-free survival rates were 71.5 and 59.6%, respectively. Anatomical laryngeal preservation was feasible in 27 patients (87.1%) during the 36-month follow-up period. Permanent gastrostomy was required in 1 disease-free patient with an intact larynx. For the entire cohort, the 2- and 3-year cumulative disease-free survival with a functional larynx was 58.5 and 50.7%, respectively. The most frequent grade 3-4 haematological and non-haematological toxicities of concurrent chemoradiotherapy were leucopenia and mucositis, which developed in 4 (12.9%) and 8 (25.8%) patients, respectively. There was no treatment-related death. Concurrent chemoradiotherapy with the XP regimen resulted in functional laryngeal preservation accompanied by disease-free survival and the toxicities were more tolerable and manageable compared to those reported by previous studies.
authors.affiliation: Departments of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University, Daegu 700-712, Republic of Korea.
authors.forename: Dongbin
authors.initials: D
authors.lastname: Ahn
authors.affiliation: Departments of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University, Daegu 700-712, Republic of Korea.
authors.forename: Jae Hyug
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Departments of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University, Daegu 700-712, Republic of Korea.
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Sohn
authors.affiliation: Departments of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University, Daegu 700-712, Republic of Korea.
authors.forename: Chang-Min
authors.initials: CM
authors.lastname: Sin
authors.affiliation: Radiation Oncology, School of Medicine, Kyungpook National University, Daegu 700-712, Republic of Korea.
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Lee
keywords: capecitabine; chemoradiotherapy; cisplatin; head and neck cancer; organ preservation