title: Nicotinamide and the skin.
abstract: Nicotinamide, an amide form of vitamin B3, boosts cellular energy and regulates poly-ADP-ribose-polymerase 1, an enzyme with important roles in DNA repair and the expression of inflammatory cytokines. Nicotinamide shows promise for the treatment of a wide range of dermatological conditions, including autoimmune blistering disorders, acne, rosacea, ageing skin and atopic dermatitis. In particular, recent studies have also shown it to be a potential agent for reducing actinic keratoses and preventing skin cancers.
authors.affiliation: Discipline of Dermatology, Bosch Institute, Central Clinical School, University of Sydney, Sydney, New South Wales, Australia; Department of Dermatology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Chen
authors.forename: Diona L
authors.initials: DL
authors.lastname: Damian
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy; D063646:Carcinogenesis / Q000187:drug effects* / Q000528:radiation effects; D003876:Dermatitis, Atopic / Q000188:drug therapy; D006801:Humans; D055623:Keratosis, Actinic / Q000188:drug therapy*; D009536:Niacinamide / Q000627:therapeutic use*; D012393:Rosacea / Q000188:drug therapy; D015595:Skin Aging / Q000187:drug effects; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy; D012878:Skin Neoplasms / Q000517:prevention & control*; D014466:Ultraviolet Rays / Q000009:adverse effects; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D014803:Vitamin B Complex; D009536:Niacinamide
keywords: nicotinamide; skin cancer; skin disease