title: Systematic review of systemic treatments for tinea versicolor and evidence-based dosing regimen recommendations.
abstract: BACKGROUND
  Extensive or recurrent tinea versicolor (TV) can be treated with systemic antifungal therapies, but no dosing regimens have been approved for this indication.
  
  
  OBJECTIVE
  To provide evidence-based recommendations for dosing regimens.
  
  
  METHODS
  A systematic literature search was performed to identify trials reporting mycologic cure. All trials were included and assessed for quality. Correlation and statistical analyses were used to evaluate the effects of different dosing regimen parameters on efficacy.
  
  
  RESULTS
  Fifty-seven trials investigating itraconazole, ketoconazole, fluconazole, and pramiconazole were included. Cumulative dose, treatment duration, and daily/weekly concentrations were shown to significantly influence mycologic cure rates for ketoconazole and pramiconazole but not for itraconazole and fluconazole.
  
  
  CONCLUSIONS
  Based on the efficacy evidence and potential safety concerns, this review supports the following dosing regimens: 200 mg/d for 5 or 7 days of itraconazole, 300 mg/wk for 2 weeks of fluconazole, and 200 mg/d for 2 days of pramiconazole.
authors.forename: Aditya K
authors.initials: AK
authors.lastname: Gupta
authors.forename: Danielle
authors.initials: D
authors.lastname: Lane
authors.forename: Maryse
authors.initials: M
authors.lastname: Paquet
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage*; D006801:Humans; D014010:Tinea Versicolor / Q000188:drug therapy*; D014230:Triazoles / Q000008:administration & dosage*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles