title: Dissolution and oral absorption of pranlukast nanosuspensions stabilized by hydroxypropylmethyl cellulose.
abstract: The objective of this study was to investigate the effect of particle size on the dissolution and oral absorption of pranlukast microsuspensions and nanosuspensions stabilized by hydroxypropylmethyl cellulose. Four pranlukast suspensions with different mean particle sizes (0.16, 0.89, 3.13, and 18.21μm) were prepared by various top-down processes such as jet milling, high pressure homogenization, and bead milling. The dissolution rate and oral absorption of pranlukast suspensions were significantly affected by the particle size. The in vivo pharmacokinetic parameters of pranlukast suspensions were increased with decreasing mean particle size of suspensions. Especially, the AUC0→24h and Cmax values of pranlukast nanosuspension with a particle size of 0.16μm were approximately 3.5- and 6.3-fold greater, respectively, than that of pranlukast microsuspension with a particle size of 18.21μm. Therefore, the preliminary results from our study suggest that a pranlukast nanosuspension with a mean particle size of about 0.16μm may have significant potential for clinical application.
authors.affiliation: College of Pharmacy, Kyungsung University, Daeyeon-dong, Nam-gu, Busan 608-736, Republic of Korea.
authors.forename: In-hwan
authors.initials: IH
authors.lastname: Baek
authors.affiliation: College of Pharmacy, Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon 305-764, Republic of Korea.
authors.forename: Jung-Soo
authors.initials: JS
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Pusan National University, 2, Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 609-735, Republic of Korea.
authors.forename: Eun-Sol
authors.initials: ES
authors.lastname: Ha
authors.affiliation: College of Pharmacy, Pusan National University, 2, Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 609-735, Republic of Korea.
authors.forename: Gwang-Ho
authors.initials: GH
authors.lastname: Choo
authors.affiliation: College of Pharmacy, Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon 305-764, Republic of Korea; Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 162-1 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea.
authors.forename: Wonkyung
authors.initials: W
authors.lastname: Cho
authors.affiliation: Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 162-1 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea; College of Pharmacy, Yonsei University, 162-1 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea.
authors.forename: Sung-Joo
authors.initials: SJ
authors.lastname: Hwang
authors.affiliation: College of Pharmacy, Pusan National University, 2, Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 609-735, Republic of Korea. Electronic address: minsookim@pusan.ac.kr.
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Kim
mesh_terms: D000284:Administration, Oral; D002867:Chromones / Q000008:administration & dosage / Q000737:chemistry*; D065546:Drug Liberation; D006801:Humans; D065347:Hypromellose Derivatives / Q000008:administration & dosage / Q000737:chemistry*; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D013535:Suspensions / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D002867:Chromones; D013535:Suspensions; D065347:Hypromellose Derivatives; C047681:pranlukast
keywords: Bioavailability; Nanosuspenion; Pranlukast