title: The common single-nucleotide polymorphism rs2681472 is associated with early-onset preeclampsia in Northern Han Chinese women.
abstract: Preeclampsia, characterized by hypertension and proteinuria, remains a leading cause of maternal morbidity and mortality. Recently, a genome-wide association study (GWAS) identified the single-nucleotide polymorphism, rs2681472, as a new hypertension susceptibility genetic variant. The purpose of this study was to evaluate the association between preeclampsia and rs268172 in a Northern Han Chinese population. We genotyped 1218 unrelated Northern Han Chinese women, including 515 patients with preeclampsia and 703 healthy controls. No significant differences were detected in the allele frequencies between patients and controls (P = .23). When patients were divided into early-onset and late-onset preeclampsia according to gestational age of disease onset, the allele frequencies significantly differed between controls and patients with early-onset preeclampsia (P = .02). Genotype frequencies also were significantly different between controls and patients early-onset preeclampsia when data were analyzed under additive (P = .03) and dominant (P = .009) models. We replicated this association in an independent Northern Han Chinese population and observed a significant difference in the allele frequencies between patients with early-onset preeclampsia and controls (P = .011). We report that rs2681472 is associated with early-onset preeclampsia in Northern Han Chinese women.
authors.affiliation: Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Ji-Peng
authors.initials: JP
authors.lastname: Wan
authors.affiliation: Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Chang-Zhong
authors.initials: CZ
authors.lastname: Li
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China National Research Center for Assisted Reproductive Technology and Reproductive Genetics, China The Key laboratory for Reproductive Endocrinology of Ministry of Education, China Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
authors.forename: Han
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China National Research Center for Assisted Reproductive Technology and Reproductive Genetics, China The Key laboratory for Reproductive Endocrinology of Ministry of Education, China Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
authors.forename: Li
authors.initials: L
authors.lastname: You
authors.affiliation: Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Dong-Hong
authors.initials: DH
authors.lastname: Shi
authors.affiliation: Department of Obstetrics and Gynecology, Qingdao Municipal Hospital, Qingdao, China.
authors.forename: Xiu-Hua
authors.initials: XH
authors.lastname: Sun
authors.affiliation: Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Lv
authors.affiliation: Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Ze-Qing
authors.initials: ZQ
authors.lastname: Wen
authors.affiliation: Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, China wangxiet@gmail.com.
authors.forename: Xie-Tong
authors.initials: XT
authors.lastname: Wang
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China National Research Center for Assisted Reproductive Technology and Reproductive Genetics, China The Key laboratory for Reproductive Endocrinology of Ministry of Education, China Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D010641:Phenotype; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult
chemical_list: C506952:ATP2B1 protein, human; D053499:Plasma Membrane Calcium-Transporting ATPases
keywords: ATP2B1; genetics; polymorphisms; preeclampsia