title: Goat milk fat naturally enriched with conjugated linoleic acid increased lipoproteins and reduced triacylglycerol in rats.
abstract: Goat milk is source of different lipids, including conjugated linoleic acid (CLA). CLA reduces body fat and protect against cardiovascular diseases. In the present study fat from goat milk naturally enriched with CLA was used. Male Wistar rats were divided into three groups that received during a 10 week diet with different lipid sources: soybean oil (CON), coconut oil (CO) and goat milk fat naturally enriched with CLA (GM-CLA). We evaluated the effects of a GM-CLA on biochemistry parameters--high density lipoprotein (HDL), triacylglycerol (TAG), TAG/HDL ratio, total cholesterol and glucose, body weight and histopathological aspects of the intestine and liver. GM-CLA increased body weight from the second to the fifth week of the experiment compared to CON. Feed intake differed between the CON group and GM-CLA early in the first to third week of the experiments and later between the ninth and tenth week. The CLA-diet group showed increased levels of HDL, reduced levels of TAG and TAG/HDL ratio and no effect on LDL, but enhanced total cholesterol. Serum glucose of the GM-CLA group showed no difference from the control group. Thus, a GM-CLA diet promoted growth in young rats and acted as protector of cardiovascular function, but further studies are still needed to clarify these effects.
authors.affiliation: Departament of Nutrition, Universidade Federal de Campina Grande, Cuité 58175-000, PB, Brazil.
authors.forename: Raphaela
authors.initials: R
authors.lastname: Rodrigues
authors.affiliation: Departament of Nutrition, Universidade Federal de Campina Grande, Cuité 58175-000, PB, Brazil. julianakessia2@gmail.com.
authors.forename: Juliana
authors.initials: J
authors.lastname: Soares
authors.affiliation: Departament of Morfology, Universidade Federal da Paraíba, João Pessoa 58051-900, PB, Brazil.
authors.forename: Hugo
authors.initials: H
authors.lastname: Garcia
authors.affiliation: Escola Técnica de Saúde, Universidade Federal da Paraíba, João Pessoa 58051-900, PB, Brazil.
authors.forename: Claudenice
authors.initials: C
authors.lastname: Nascimento
authors.affiliation: Departament of Physiology and Pathology, Universidade Federal da Paraíba, João Pessoa 58051-900, PB, Brazil.
authors.forename: Maria
authors.initials: M
authors.lastname: Medeiros
authors.affiliation: Empresa Brasileira de Pesquisa Agropecuária, EMBRAPA Caprinos e Ovinos, Sobral 62010-970, CE, Brazil.
authors.forename: Marco
authors.initials: M
authors.lastname: Bomfim
authors.affiliation: Departament of Nutrition, Universidade Federal de Pernambuco, Recife 50670-901, PE, Brazil.
authors.forename: Maria Carmo
authors.initials: MC
authors.lastname: Medeiros
authors.affiliation: Departament of Nutrition, Universidade Federal da Paraíba, João Pessoa 58051-900, PB, Brazil.
authors.forename: Rita
authors.initials: R
authors.lastname: Queiroga
mesh_terms: D000818:Animals; D001835:Body Weight; D004032:Diet; D004041:Dietary Fats; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism; D006041:Goats; D044243:Linoleic Acids, Conjugated / Q000737:chemistry*; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008892:Milk / Q000737:chemistry*; D051381:Rats; D014280:Triglycerides / Q000097:blood*
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D044243:Linoleic Acids, Conjugated; D008074:Lipoproteins; D014280:Triglycerides