title: [Real-time three dimensional echocardiography-based evaluation of left ventricular function in children with Kawasaki disease].
abstract: OBJECTIVE
  To evaluate the clinical significance of full volume real-time three-dimensional echocardiography (RT-3DE) in the assessment of general and local systolic functions of the left ventricle in children with Kawasaki disease (KD).
  
  
  METHODS
  A total of 73 KD children (40 with and 33 without coronary artery lesions) and 35 healthy control children were recruited. Left ventricular ejection fraction (LVEF) was measured by M-mode ultrasound and full volume RT-3DE imaging. A left ventricular volume-time curve and a segmental speed-time curve were generated. Differences between control subjects and patients with and without coronary artery lesions were analyzed.
  
  
  RESULTS
  The M-mode ultrasound measurements of LVEF in KD patients with coronary artery lesions were significantly lower than in KD patients without coronary artery lesions and control children (P<0.05), while there was no significant difference between KD patients without coronary artery lesions and control children. RT-3DE measurements of LVEF were significantly different between the three groups analyzed (P<0.05): coronary artery lesion group < no coronary artery lesion group < control group. RT-3DE-based segmental ventricular wall analysis revealed that Tmsv16-SD and Tmsv12-SD in KD patients with coronary artery lesions were significantly higher than other two groups and Tmsv6-SD was also significantly higher than in the normal control group (P<0.05) and that Tmsv16-SD in KD patients without coronary artery lesions increased significantly compared with the normal control group (P<0.05).
  
  
  CONCLUSIONS
  RT-3DE can be used in the quantitative evaluation of the left ventricular function and therefore has significant clinical implications.
authors.affiliation: Department of Physical Diagnosis, Longnan Hospital, Daqing, Heilongjiang 163453, China. 734421258@qq.com.
authors.forename: Xiao-Xu
authors.initials: XX
authors.lastname: Chen
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Fu
authors.forename: Peng-Xiang
authors.initials: PX
authors.lastname: Zhou
authors.forename: Xin-Tong
authors.initials: XT
authors.lastname: Zhou
mesh_terms: D002648:Child; D002675:Child, Preschool; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016277:Ventricular Function, Left