title: Magnetic metal-organic frameworks: γ-Fe2O3@MOFs via confined in situ pyrolysis method for drug delivery.
abstract: A general one-step in situ pyrolysis route for the construction of metal-organic frameworks encapsulating superparamagnetic γ-Fe2O3NPs dispersed in the confined cavities of MOFs homogeneously is described. The integration of γ-Fe2O3 NPs or clusters into MOFs can endow these porous materials with superparamagnetic element. By the combination of the thermal stability of MOFs and pyrolysis of metal triacetylacetonate complex at matched conditions, the porous structure of MOFs are well maintained while the size-induced superparamagnetic property of nano γ-Fe2O3 is obtained. As a proof of concept, both the γ- Fe2O3@ZIF-8 and γ-Fe2O3@MIL-53(Al) were successfully prepared, and the latter was chosen to demonstrate its potential drug delivery as a magnetic MOF.
authors.affiliation: College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai, 200092, P. R. China.
authors.forename: Yi-nan
authors.initials: YN
authors.lastname: Wu
authors.forename: Meimei
authors.initials: M
authors.lastname: Zhou
authors.forename: Shu
authors.initials: S
authors.lastname: Li
authors.forename: Zehua
authors.initials: Z
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Baozhen
authors.initials: B
authors.lastname: Wu
authors.forename: Guangtao
authors.initials: G
authors.lastname: Li
authors.forename: Fengting
authors.initials: F
authors.lastname: Li
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Guan
mesh_terms: D016503:Drug Delivery Systems; D006358:Hot Temperature; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D017348:Microscopy, Electron, Scanning Transmission; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D058185:Magnetite Nanoparticles
keywords: drug delivery; maghemite; metal-organic frameworks; nanoconfinement; superparamagnetism