title: Assessing cellular response to functionalized α-helical peptide hydrogels.
abstract: α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom-up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.
authors.affiliation: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
authors.forename: Nazia
authors.initials: N
authors.lastname: Mehrban
authors.forename: Edgardo
authors.initials: E
authors.lastname: Abelardo
authors.forename: Alexandra
authors.initials: A
authors.lastname: Wasmuth
authors.forename: Kieran L
authors.initials: KL
authors.lastname: Hudson
authors.forename: Leanne M
authors.initials: LM
authors.lastname: Mullen
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Thomson
authors.forename: Martin A
authors.initials: MA
authors.lastname: Birchall
authors.forename: Derek N
authors.initials: DN
authors.lastname: Woolfson
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D057930:Click Chemistry; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology*; D008422:Materials Testing; D051379:Mice; D049329:Nanostructures / Q000737:chemistry; D016716:PC12 Cells; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D010455:Peptides
keywords: 2D cell culture; PC12 cells; peptide hydrogels; self-assembled fibers; tissue engineering