title: [Taste receptors in the lungs: interesting or anecdotal?].
abstract: The receptors responsible for taste perception distinguish the four basic tastes : salty, sweet, bitter and umami. Among them, the bitter taste receptors (TAS2R) are G protein coupled receptors, including 25 subtypes identified in humans to date. Although the existence of endogenous agonists remains uncertain, the TAS2R receptors have the ability to recognize natural or synthetic molecules, as various molecules produced by bacteria, or caffeine, chloroquine, or erythromycin. The expression of these receptors, initially thought to be confined to the oral cavity, has recently been described in extra-oral tissues such as the gastrointestinal tract and the lungs. The effects in the lung tissue are essentially at three levels : TAS2R receptors expressed on the cilia of epithelial cells increase the cilia vibration frequency; the stimulation of TAS2R receptors expressed in bronchial smooth muscle cells leads to bronchial relaxation; while TAS2R receptors expressed on immune cells in the lung tissue, including macrophages, are involved in the modulation of the production of pro-inflammatory cytokines. In conclusion, in view of these complementary mechanisms, TAS2R receptors may become a pharmacological target of interest for the treatment of obstructive lung diseases.
authors.affiliation: Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France. Electronic address: s.grassindelyle@hopital-foch.org.
authors.forename: S
authors.initials: S
authors.lastname: Grassin-Delyle
authors.affiliation: Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France.
authors.forename: C
authors.initials: C
authors.lastname: Abrial
authors.affiliation: Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France.
authors.forename: M
authors.initials: M
authors.lastname: Brollo
authors.affiliation: Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France; Université Versailles Saint-Quentin, UFR sciences de la santé Simone-Veil, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-Le-Bretonneux, France.
authors.forename: E
authors.initials: E
authors.lastname: Naline
authors.affiliation: Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France; Université Versailles Saint-Quentin, UFR sciences de la santé Simone-Veil, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-Le-Bretonneux, France.
authors.forename: P
authors.initials: P
authors.lastname: Devillier
mesh_terms: D000818:Animals; D002923:Cilia / Q000502:physiology; D004847:Epithelial Cells / Q000502:physiology; D006801:Humans; D008168:Lung / Q000737:chemistry / Q000166:cytology / Q000502:physiology*; D009126:Muscle Relaxation / Q000502:physiology; D032389:Myocytes, Smooth Muscle / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000502:physiology*; D013649:Taste / Q000502:physiology*
chemical_list: D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled
keywords: Bitter taste receptors; Lung; Poumons; Récepteurs à l’amertume