title: Hyaluronic acid fat graft myringoplasty vs fat patch fat graft myringoplasty.
abstract: We aim to compare the hyaluronic acid to fat graft myringoplasty (HAFGM) technique to a recently described modified-FGM (M-FGM) in the repair of tympanic membrane perforation (TMP). We also aim to evaluate the hearing level improvement postoperatively. We conducted a prospective study in an adult tertiary care center between 2012 and 2013. Adult patients presenting with simple TMP were operated on randomly using either HAFGM or M-FGM under local anesthesia in outpatients' settings. Success was considered when complete closure is achieved. Audiometric parameters were evaluated pre and postoperatively. Twenty-four patients were included in the study (HAFGM: 10 patients and M-FGM: 14 patients). Complete closure was achieved in 80 % in HAFGM vs 42.8 % in the M-FGM (p = 0.03). The study was abandoned due to the low success rate in first 14 patients of the M-FGM group. The pure tone audiometry was improved postoperatively in the HAFGM only. The study was aborted because of the unsatisfactory obtained results using the MFGM. It also shows the beneficial effect of hyaluronic acid application to FGM for a successful TMP repair.
authors.affiliation: Division of Otolaryngology, Head and Neck Surgery, Montreal University Hospital Center (CHUM), University of Montreal, 1560, rue Sherbrooke East, Montreal, QC, H2L 4M1, Canada.
authors.forename: Musaed
authors.initials: M
authors.lastname: Alzahrani
authors.forename: Issam
authors.initials: I
authors.lastname: Saliba
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000328:Adult; D000368:Aged; D000772:Anesthesia, Local / Q000379:methods; D001301:Audiometry, Pure-Tone / Q000379:methods; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009225:Myringoplasty / Q000295:instrumentation / Q000379:methods; D019990:Perioperative Care / Q000379:methods; D016896:Treatment Outcome; D018058:Tympanic Membrane Perforation / Q000601:surgery*; D014945:Wound Healing
chemical_list: D006820:Hyaluronic Acid