title: Salvianolic acid A positively regulates PTEN protein level and inhibits growth of A549 lung cancer cells.
abstract: Salvianolic acid A (Sal A) is an effective compound extracted fromSalvia miltiorrhizawhich has been used in the treatment of various diseases. Preliminary data indicate that Sal A treatment has a specific anti-lung cancer effect. However, the manner in which Sal A regulates cancer growth remains unknown. In this study, the A549 lung cancer cell line and its response to Sal A treatment was examined. Results showed that Sal A treatment significantly decreased A549 cell growth, promoted partial apoptosis and increased mitochondrial membrane permeability. Western blot analysis showed that Sal A upregulated the phosphatase and tensin homolog (PTEN) protein level, while consistently downregulating Akt phosphorylation. These results indicate that Sal A negatively mediates A549 lung cancer cell line growth or apoptosis, most likely by positively regulating PTEN protein level.
authors.affiliation: The Associated Hospital of Nanjing University of Chinese Medicine, Nanjing 210046, P.R. China ;
authors.forename: Lei
authors.initials: L
authors.lastname: Bi
authors.affiliation: College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing 210046, P.R. China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Chen
authors.affiliation: College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing 210046, P.R. China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Yuan
authors.affiliation: College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing 210046, P.R. China.
authors.forename: Zequn
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing 210046, P.R. China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Chen
keywords: Akt phosphorylation; apoptosis; phosphatase and tensin homolog; salvianolic acid A