title: Long-term supplementation of umbelliferone and 4-methylumbelliferone alleviates high-fat diet induced hypertriglyceridemia and hyperglycemia in mice.
abstract: This study was conducted to evaluate the effects of umbelliferone (UF) and 4-methylumbelliferone (mUF) on high-fat diet-induced hypertriglyceridemia and hyperglycemia in mice. The mice were assigned to normal control, high-fat control, and high-fat with UF or mUF groups. For UF or mUF groups, the high-fat diet was supplemented with UF or mUF at 0.02% (wt/wt) for 12weeks. Both UF and mUF significantly decreased plasma triglyceride, free fatty acid and glucose levels, adipocyte size, white adipose tissue weights, and hepatic phosphatidate phosphohydrolase activity and significantly increased plasma adiponectin levels and hepatic fatty acid β-oxidation activity compared with the high-fat control group. UF and mUF improved glucose intolerance and hepatic steatosis in the high-fat fed mice. Long-term high-fat diet intake induced an increase in hepatic CYP2E1 activity and lipid peroxide and cytosolic hydrogen peroxide contents and suppressed superoxide dismutase and glutathione peroxidase activities, which were reversed by UF and mUF supplementation. These results indicate that UF and mUF similarly ameliorate hypertriglyceridemia and hyperglycemia partly by modulating hepatic lipid metabolism and the antioxidant defense system along with increasing adiponectin levels.
authors.affiliation: Department of Food and Nutrition, Sunchon National University, Suncheon 540-950, Republic of Korea.
authors.forename: Mi-Ok
authors.initials: MO
authors.lastname: Sim
authors.affiliation: Department of Food and Nutrition, Sunchon National University, Suncheon 540-950, Republic of Korea.
authors.forename: Ju Ri
authors.initials: JR
authors.lastname: Ham
authors.affiliation: Department of Food and Nutrition, Sunchon National University, Suncheon 540-950, Republic of Korea.
authors.forename: Hae-In
authors.initials: HI
authors.lastname: Lee
authors.affiliation: Department of Food and Nutrition, Sunchon National University, Suncheon 540-950, Republic of Korea.
authors.forename: Kwon-Il
authors.initials: KI
authors.lastname: Seo
authors.affiliation: Department of Food and Nutrition, Sunchon National University, Suncheon 540-950, Republic of Korea. Electronic address: leemk@sunchon.ac.kr.
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D019587:Dietary Supplements; D002149:Energy Intake; D005786:Gene Expression Regulation; D006923:Hymecromone / Q000008:administration & dosage*; D006943:Hyperglycemia / Q000139:chemically induced* / Q000188:drug therapy; D015228:Hypertriglyceridemia / Q000139:chemically induced* / Q000188:drug therapy; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood / Q000737:chemistry; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D014468:Umbelliferones / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D008055:Lipids; D014468:Umbelliferones; D006923:Hymecromone; C031477:7-hydroxycoumarin; D019392:Cytochrome P-450 CYP2E1
keywords: 4-Methylumbelliferone; Antioxidant; High-fat diet; Hyperglycemia; Hypertriglyceridemia; Umbelliferone