title: Nonhomologous end joining: a good solution for bad ends.
abstract: Double strand breaks pose unique problems for DNA repair, especially when broken ends possess complex structures that interfere with standard DNA transactions. Nonhomologous end joining can use multiple strategies to solve these problems. It further uses sophisticated means to ensure the strategy chosen provides the ideal balance of flexibility and accuracy.
authors.affiliation: Department of Biochemistry and Biophysics and Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: cawaters@email.unc.edu.
authors.forename: Crystal A
authors.initials: CA
authors.lastname: Waters
authors.affiliation: Department of Biochemistry and Biophysics and Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: strande@email.unc.edu.
authors.forename: Natasha T
authors.initials: NT
authors.lastname: Strande
authors.affiliation: Department of Biochemistry and Biophysics and Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: dwwyatt@email.unc.edu.
authors.forename: David W
authors.initials: DW
authors.lastname: Wyatt
authors.affiliation: Department of Biochemistry and Biophysics and Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: pryorjm@email.unc.edu.
authors.forename: John M
authors.initials: JM
authors.lastname: Pryor
authors.affiliation: Department of Biochemistry and Biophysics and Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: dale_ramsden@med.unc.edu.
authors.forename: Dale A
authors.initials: DA
authors.lastname: Ramsden
mesh_terms: D000818:Animals; D001665:Binding Sites; D053903:DNA Breaks, Double-Stranded; D059766:DNA End-Joining Repair; D045643:DNA Repair Enzymes / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular
chemical_list: D045643:DNA Repair Enzymes
keywords: DNA damage; Double strand break repair; Nonhomologous end joining