title: Association of serum osteoprotegerin levels with carotid-femoral pulse wave velocity in hypertensive patients.
abstract: Osteoprotegerin (OPG) has been implicated in the process of vascular stiffness. The aim of this study was to evaluate the relationship between fasting serum OPG concentration and carotid-femoral pulse wave velocity (c-f PWV) in hypertensive patients. Fasting blood samples were obtained from 184 participants with or without hypertension. c-f PWV were performed by SphygmoCor system. Serum OPG levels were measured using a commercially available enzyme-linked immunosorbent assay. Hypertensive patients who had diabetes had higher c-f PWV levels than those without diabetes (P=.031). The univariable linear regression analysis showed that age (P<.001), systolic blood pressure (P=.003), pulse pressure (r=0.287; P=.003), log-BUN (P=.011), Cre (P<.001), and log-OPG concentration (P<.001) were positively correlated with c-f PWV levels, while the glomerular filtration rate (P=.005) and HDL-C level (P=.024) was negatively correlated with c-f PWV levels among the hypertensive patients. Multivariable forward stepwise linear regression analysis of the significant variables also showed that log-OPG (β=0.312, regression coefficient: 1.736; 95% confidence interval, 0.809-2.663; P<.001) was still an independent predictor of c-f PWV levels in hypertensive patients. Serum OPG levels positively associated with c-f PWV levels in hypertensive patients.
authors.affiliation: Division of Cardiology, School of Medicine, Tzu Chi University, Hualien, Taiwan; Buddhist Tzu Chi General Hospital, School of Medicine, Tzu Chi University, Hualien, Taiwan.
authors.forename: Ji-Hung
authors.initials: JH
authors.lastname: Wang
authors.forename: Chung-Jen
authors.initials: CJ
authors.lastname: Lee
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Chen
authors.forename: Chiu-Fen
authors.initials: CF
authors.lastname: Yang
authors.forename: Yu-Chih
authors.initials: YC
authors.lastname: Chen
authors.forename: Bang-Gee
authors.initials: BG
authors.lastname: Hsu
mesh_terms: D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D002339:Carotid Arteries / Q000503:physiopathology*; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology*; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D053244:Osteoprotegerin / Q000097:blood*; D063177:Pulse Wave Analysis
chemical_list: D008076:Cholesterol, HDL; D053244:Osteoprotegerin