title: Polymorphisms in genes involved in fatty acid β-oxidation interact with dietary fat intakes to modulate the plasma TG response to a fish oil supplementation.
abstract: A large inter-individual variability in the plasma triglyceride (TG) response to an omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation has been observed. The objective was to examine gene-diet interaction effects on the plasma TG response after a fish oil supplementation, between single-nucleotide polymorphisms (SNPs) within genes involved in fatty acid β-oxidation and dietary fat intakes. Two hundred and eight (208) participants were recruited in the greater Quebec City area. The participants completed a six-week fish oil supplementation (5 g fish oil/day: 1.9-2.2 g EPA and 1.1 g DHA). Dietary fat intakes were measured using three-day food records. SNPs within RXRA, CPT1A, ACADVL, ACAA2, ABCD2, ACOX1 and ACAA1 genes were genotyped using TAQMAN methodology. Gene-diet interaction effects on the plasma TG response were observed for SNPs within RXRA (rs11185660, rs10881576 and rs12339187) and ACOX1 (rs17583163) genes. For rs11185660, fold changes in RXRA gene expression levels were different depending on SFA intakes for homozygotes T/T. Gene-diet interaction effects of SNPs within genes involved in fatty acid β-oxidation and dietary fat intakes may be important in understanding the inter-individual variability in plasma TG levels and in the plasma TG response to a fish oil supplementation.
authors.affiliation: Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd., Quebec, QC, G1V 0A6, Canada. iwona.rudkowska@kin.ulaval.ca.
authors.forename: Annie
authors.initials: A
authors.lastname: Bouchard-Mercier
authors.affiliation: Endocrinology and Nephrology, CHU de Quebec Research Center, 2705 Laurier Blvd., Quebec, QC, G1V 4G2, Canada. iwona.rudkowska@kin.ulaval.ca.
authors.forename: Iwona
authors.initials: I
authors.lastname: Rudkowska
authors.affiliation: Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd., Quebec, QC, G1V 0A6, Canada. simone.lemieux@fsaa.ulaval.ca.
authors.forename: Simone
authors.initials: S
authors.lastname: Lemieux
authors.affiliation: Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd., Quebec, QC, G1V 0A6, Canada. iwona.rudkowska@kin.ulaval.ca.
authors.forename: Patrick
authors.initials: P
authors.lastname: Couture
authors.affiliation: Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd., Quebec, QC, G1V 0A6, Canada. marie-claude.vohl@fsaa.ulaval.ca.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Vohl
mesh_terms: D000074061:ATP Binding Cassette Transporter, Subfamily D; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000102:Acetyl-CoA C-Acyltransferase / Q000235:genetics; D044942:Acyl-CoA Dehydrogenase, Long-Chain / Q000235:genetics; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D002334:Carnitine O-Palmitoyltransferase / Q000235:genetics; D002784:Cholesterol / Q000097:blood; D004032:Diet; D019587:Dietary Supplements; D005215:Fasting; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D015870:Gene Expression; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D008066:Lipolysis / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011792:Quebec; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference; D055815:Young Adult
chemical_list: C431694:ABCD2 protein, human; D000074061:ATP Binding Cassette Transporter, Subfamily D; D018528:ATP-Binding Cassette Transporters; D001786:Blood Glucose; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D014280:Triglycerides; D002784:Cholesterol; D044942:Acyl-CoA Dehydrogenase, Long-Chain; C467805:ACADVL protein, human; C570764:ACAA1 protein, human; D000102:Acetyl-CoA C-Acyltransferase; C577474:CPT1A protein, human; D002334:Carnitine O-Palmitoyltransferase