title: [Effect of bosentan on intimal hyperplasia of carotid artery anastomoses in rabbits].
abstract: OBJECTIVE
  We investigated the effect of bosentan on intimal hyperplasia of carotid artery anastomoses in rabbits.
  
  
  METHODS
  Eighteen New Zealand male rabbits were randomized into two groups, as drug (Group B) and non-drug (Group A). The right carotid artery of all the subjects was transected and anastomosed end-to-end with 10/0 polypropylene suture. The left carotid artery was left intact. Group B subjects received 30 mg/kg/day oral bosentan for 21 days, starting 3 days before the operation. Group A subjects did not receive any medication. After 28 days, the anastomoses site and the contralateral control site were removed, and samples were investigated histomorphometrically.
  
  
  RESULTS
  Significant intimal hyperplasia was observed at all anastomoses compared to the non-anastomotic left side. Bosentan decreased significantly the intimal area [Group A: 48.3 µm(2) (37.1 µm(2)-65.7 µm(2)), Group B: 31.4 µm(2) (12.2 µm(2)-63.2 µm(2)), (p=0.04)] and intima/media area ratio [Group A: 0.49 (0.13-0.74), Group B: 0.22 (0.09-0.37), (p=0.024)] compared to the non-drug group.
  
  
  CONCLUSIONS
  According to our investigation, bosentan decreased the intimal hyperplasia developed in a rabbit carotid artery model. Further investigations are needed to support the potential clinical utilization of bosentan after vascular interventions.
authors.affiliation: Department of Cardiology, Medical Park Hospital, Samsun, Turkey. artanjahollari@gmail.com.
authors.forename: Artan
authors.initials: A
authors.lastname: Jahollari
authors.affiliation: Department of Cardiovascular Surgery, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Anar
authors.initials: A
authors.lastname: Emrahov
authors.affiliation: Department of Cardiovascular Surgery, Diyarbakır Military Hospital, Diyarbakır, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Tavlaşoğlu
authors.affiliation: Department of Cardiovascular Surgery, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kürklüoğlu
authors.affiliation: Department of Cardiovascular Surgery, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Şahin
authors.affiliation: Department of Cardiovascular Surgery, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Güler
authors.affiliation: Department of Cardiology, Medical Park Hospital, Samsun, Turkey.
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Özal
authors.affiliation: Department of Cardiovascular Surgery, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Arslan
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D000077300:Bosentan; D002339:Carotid Arteries / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D065128:Endothelin Receptor Antagonists / Q000494:pharmacology*; D006965:Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D013449:Sulfonamides / Q000494:pharmacology*; D017539:Tunica Intima / Q000187:drug effects* / Q000473:pathology
chemical_list: D065128:Endothelin Receptor Antagonists; D013449:Sulfonamides; D000077300:Bosentan