title: [Significance of allelic variants of interleukin-28B gene in chronic hepatitis C].
abstract: Chronic hepatitis C remains one of the most urgent problems of today's medicine. The review unravels the current view of the role of a single nucleotide polymorphism of the interleukin-28B (IL-28B) gene in different aspects of hepatitis C virus infection. Major attention is paid to the discussion of the value of the allelic variants of IL-28B during standard double and current triple antiviral therapy for chronic hepatitis C. Furthermore, the paper covers the biological role of interferon-lambda, a product of IL-28A, B, and IL-29 gene expression, other associations of the allelic variants of the IL-28B gene with different clinical signs, as well as the possibilities of practical use of this genetic marker in chronic hepatitis C today and futures prospects.
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Tikhonova
authors.forename: É Z
authors.initials: ÉZ
authors.lastname: Burnevich
authors.forename: T N
authors.initials: TN
authors.lastname: Krasnova
mesh_terms: D000483:Alleles; D014644:Genetic Variation; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda