title: An integrated medical treatment for type-2 diabetes.
abstract: This paper tries to emphasize two relevant concepts: the first is that type 2 diabetes is a chronic diseases characterized by both a dysmetabolism and a chronic oxidative stress. A variety of orthodox drugs are somewhat able to correct the metabolic alterations, but do not deal with the chronic inflammation. Consequently, as the validity of precisely treating blood with therapeutic ozone concentrations in restoring a redox homeostasis has been now demonstrated, the integration of ozone therapy appears essential for a rational treatment of type 2 diabetes. Such a combination may be able to reduce the diabetic epidemic.
authors.affiliation: Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy. Electronic address: velio.bocci@unisi.it.
authors.forename: Velio
authors.initials: V
authors.lastname: Bocci
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Maastricht University Medical Centre (MUMC), Maastricht, The Netherlands.
authors.forename: Iacopo
authors.initials: I
authors.lastname: Zanardi
authors.affiliation: Department of Physiology, University of Siena, Siena, Italy.
authors.forename: Maya S P
authors.initials: MS
authors.lastname: Huijberts
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Maastricht University Medical Centre (MUMC), Maastricht, The Netherlands. Electronic address: valter.travagli@unisi.it.
authors.forename: Valter
authors.initials: V
authors.lastname: Travagli
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D010126:Ozone / Q000097:blood / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D010126:Ozone
keywords: Antioxidants; Diabetes; Nrf2 activation; Oxidative stress; Oxygen-ozonetherapy