title: [Clinical research of early, enough methylprednisone combined with immunoglobulin in treatment of severe hand-foot-mouth disease].
abstract: OBJECTIVE
  To study the efficacy of early, enough methylprednisone combined with immunoglobulin in treatments of severe hand-foot-mouth disease.
  
  
  METHODS
  568 patients of severe hand-foot-mouth disease involved were randomized into group A and group B. Patients of both groups all accepted symptomatic treatment, supportive therapy and the treatment of control intracranial pressure. And patients in group A received the treatment of early, enough methylprednisone combined with immunoglobulin, whereas patients in group B received conventional therapy. RESULTS; Curative rate of group A was better than that of group B, otherwise incidence rate of critical illness was less than that of group B. The control time of fever, erythra, neurological symptoms, features of pneumonia and increased leukocyte of group A was shorter than that of group B, and no more recent or Long-term treatment-related adverse reaction in group A.
  
  
  CONCLUSIONS
  Early, enough methylprednisone combined with immunoglobulin is effective, safe in treating severe hand-foot-mouth disease, and worthy to recommand its clinical use.
authors.forename: Ming
authors.initials: M
authors.lastname: Jiang
authors.forename: Xing-Chuan
authors.initials: XC
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D035843:Biomedical Research; D004359:Drug Therapy, Combination; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000188:drug therapy*; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use*; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D007136:Immunoglobulins; D008776:Methylprednisolone Hemisuccinate