title: Selective accumulation of [⁶²Zn]-labeled glycoconjugated porphyrins as multi-functional positron emission tomography tracers in cancer cells.
abstract: Positron-emission tomography (PET) can be used to visualize active stage cancer. Fluorine-18 ([(18)F])-labeled 2-([(18)F])2-deoxy-2-fluoroglucose (([(18)F])-FDG), which accumulates in glucose-dependent tissues, is a good cancer-targeting tracer. However, ([(18)F])-FDG is obscured in glucose-dependent normal tissues. In this study, we assessed the cancer-selective accumulation of zinc-labeled glycoconjugated 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (ZnGlc1-4), both in vitro and in vivo. Experiments using both normal and cancer cells confirmed the relationship between cancer cell-selective accumulation and the substitution numbers and orientations of glycoconjugated porphyrins. ZnGlctrans-2 accumulated at greater levels in cancer cells compared with other glycoconjugated porphyrins. PET imaging showed that ZnGlctrans-2 accumulated in tumor.
authors.affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba, Ibaraki 305-8573, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Tamura
authors.affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba, Ibaraki 305-8573, Japan. Electronic address: hmatsui@md.tsukuba.ac.jp.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Matsui
authors.affiliation: Department of Chemical and Biological Engineering, Ube National College of Technology, 2-14-1 Tokiwadai, Ube 755-8555, Japan; Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), Ikoma, Nara 630-0192, Japan.
authors.forename: Shiho
authors.initials: S
authors.lastname: Hirohara
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), Ikoma, Nara 630-0192, Japan.
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Kakiuchi
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), Ikoma, Nara 630-0192, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Tanihara
authors.affiliation: Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.
authors.forename: Naruto
authors.initials: N
authors.lastname: Takahashi
authors.affiliation: Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.
authors.forename: Kozi
authors.initials: K
authors.lastname: Nakai
authors.affiliation: Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita-city, Osaka 565-0871, Japan.
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Kanai
authors.affiliation: Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita-city, Osaka 565-0871, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watabe
authors.affiliation: Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita-city, Osaka 565-0871, Japan; Department of Nuclear Medicine, WPI Immunology Frontier Research Center, 2-2 Yamadaoka, Suita-city, Osaka 565-0871, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Hatazawa
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D008279:Magnetic Resonance Imaging; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009369:Neoplasms / Q000000981:diagnostic imaging; D011166:Porphyrins / Q000737:chemistry* / Q000378:metabolism; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000378:metabolism; D051381:Rats; D014018:Tissue Distribution; D014183:Transplantation, Heterologous; D015037:Zinc Radioisotopes / Q000737:chemistry
chemical_list: D011166:Porphyrins; D019275:Radiopharmaceuticals; D015037:Zinc Radioisotopes
keywords: Cancer selective accumulation; Positron emission tomography; [(62)Zn]-labeling PET tracer; [(62)Zn]-zinc porphyrins