title: Maxillary pain is the first indication of the presence of multiple myeloma: A case report.
abstract: Multiple myeloma is a primary malignancy of bone marrow characterized by the clonal proliferation of plasma cells and production of monoclonal immunoglobulin. The disease occurs more frequently in males, with the average age at diagnosis being ∼60 years. The first manifestation of multiple myeloma is varied and depends on the sites and extent of involvement. The predominant clinical symptoms of multiple myeloma are associated with bone pain and renal dysfunction. Neoplastic cells usually produce large amounts of monoclonal immunoglobulin light or heavy chains that can be detected in serum or urine, while plasmacytoma may be identified on marrow biopsy. The present study reported on the case of a 69-year-old male patient presenting with a complaint of a painful lesion in the left maxilla. Physical examination, imaging, laboratory investigations and biopsy were conducted, confirming the diagnosis of multiple myeloma. The results obtained suggest that the dentist should address oral manifestations as first indications of multiple myeloma.
authors.affiliation: Divisions of Nephrology, Shanghai Ninth Peoples' Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China.
authors.forename: Xiao Jiao
authors.initials: XJ
authors.lastname: Zhao
authors.affiliation: Oral and Maxillofacial Surgery, Shanghai Ninth Peoples' Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.affiliation: Divisions of Nephrology, Shanghai Ninth Peoples' Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China.
authors.forename: Ying Deng
authors.initials: YD
authors.lastname: Wang
authors.affiliation: Divisions of Nephrology, Shanghai Ninth Peoples' Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
keywords: maxillary pain; multiple myeloma