title: Separation and structural elucidation of a new tadalafil analogue diethylaminopretadalafil included as an adulterant in a dietary supplement.
abstract: A new tadalafil analogue was detected and isolated from a dietary supplement, the structure was elucidated by means of nuclear magnetic resonance (NMR) and mass spectroscopy. The compound was determined to be diethylaminopretadalafil, which might be derived from a precursor in the synthesis of tadalafil.
authors.affiliation: Shenzhen Institute for Drug Control, Shenzhen, China.
authors.forename: Gaofei
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Shenzhen Institute for Drug Control, Shenzhen, China. Electronic address: yuyue172@sohu.com.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Shenzhen Institute for Drug Control, Shenzhen, China.
authors.forename: Xiaoou
authors.initials: X
authors.lastname: Wu
authors.affiliation: Shenzhen Institute for Drug Control, Shenzhen, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D002243:Carbolines / Q000737:chemistry*; D019587:Dietary Supplements / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D000068581:Tadalafil
chemical_list: D002243:Carbolines; D000068581:Tadalafil
keywords: Adulterant; Dietary supplement; Diethylaminopretadalafil; PDE-5 inhibitor; Tadalafil analogue