title: Corrective osteotomy in femoral non-union in drug-induced hypophosphataemic osteomalacia.
abstract: Adefovir/tenofovir are commonly used antiviral agents in the treatment of chronic hepatitis B infection (CHB). We report a case of CHB-related cirrhosis presenting with sequential femoral neck fractures. Operative reduction and fixation was performed. Laboratory result and imaging was consistent with hypophosphataemic osteomalacia. He had bilateral femoral neck non-union and presented with a new left side subtrochanteric femoral fracture. Corrective osteotomy and cephalomedullary fixation was performed. The fractures healed in 6 months after correction of the hypophosphataemia.
authors.affiliation: Department of Orthopaedics and Traumatology, North District Hospital, New Territories, Hong Kong SAR.
authors.forename: Yan Kit
authors.initials: YK
authors.lastname: Sit
authors.forename: Tun Hing
authors.initials: TH
authors.lastname: Lui
mesh_terms: D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000998:Antiviral Agents / Q000009:adverse effects*; D005265:Femoral Neck Fractures / Q000209:etiology / Q000601:surgery*; D005594:Fracture Fixation, Intramedullary; D005599:Fractures, Ununited / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000009:adverse effects*; D010027:Osteotomy; D063730:Rickets, Hypophosphatemic / Q000139:chemically induced* / Q000150:complications
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; C053001:adefovir; D000225:Adenine