title: Impaired mismatch negativity is associated with current functional status rather than genetic vulnerability to schizophrenia.
abstract: The aim of this study is to investigate whether mismatch negativity (MMN) is associated with functional status or is a state-independent trait for schizophrenia. We assessed MMN in 26 patients with schizophrenia, 20 healthy subjects with high genetic loading, and 48 healthy controls. Repeated measures analysis of variance and Pearson׳s correlations were used to test the hypothesis that MMN is not state-independent. We found a significant main effect of group, indicating differences in the peak amplitudes of the MMN among the three groups. Post-hoc analyses revealed that schizophrenia patients showed a significant reduction in the peak amplitude of MMN, but subjects at high genetic risk and healthy controls did not. Additionally, significant correlations between Global Assessment of Functioning scores and MMN peak amplitude at Fz and Cz were found in patients with schizophrenia. These findings suggest that MMN may reflect current functional status rather than a genetic risk for schizophrenia.
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Minah
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human Behavioral Sciences, Seoul National University, Medical Research Center, Seoul, Republic of Korea.
authors.forename: Sung Nyun
authors.initials: SN
authors.lastname: Kim
authors.affiliation: Department of Brain and Cognitive Science, Seoul National University College of Natural Science, Seoul, Republic of Korea.
authors.forename: Suji
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human Behavioral Sciences, Seoul National University, Medical Research Center, Seoul, Republic of Korea.
authors.forename: Min Soo
authors.initials: MS
authors.lastname: Byun
authors.affiliation: Institute of Human Behavioral Sciences, Seoul National University, Medical Research Center, Seoul, Republic of Korea.
authors.forename: Kyung Soon
authors.initials: KS
authors.lastname: Shin
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hye Youn
authors.initials: HY
authors.lastname: Park
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Joon Hwan
authors.initials: JH
authors.lastname: Jang
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human Behavioral Sciences, Seoul National University, Medical Research Center, Seoul, Republic of Korea; Department of Brain and Cognitive Science, Seoul National University College of Natural Science, Seoul, Republic of Korea. Electronic address: kwonjs@snu.ac.kr.
authors.forename: Jun Soo
authors.initials: JS
authors.lastname: Kwon
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000235:genetics / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D055815:Young Adult
keywords: Event-related potential; Functional status; Genetic high risk; Mismatch negativity; Schizophrenia