title: [Clinical application of cyanoacrylates for prevention of cerebrospinal fluid leakage].
abstract: OBJECTIVE
  To explore the effectiveness of cyanoacrylates (Fuaile) for spinal subdural benign tumorectomy to prevent the cerebrospinal fluid leakage.
  
  
  METHODS
  Between January 2009 and March 2013, 35 patients underwent spinal subdural benign tumorectomy. Of 35 patients, Fuaile and gelatin sponge were used after stitch suture for a watertight closure of the dura in 19 cases (trial group), and only gelatin sponge was used after stitch suture in 16 cases (control group). There was no significant difference in gender, age, disease duration, types of tumors, and sites of tumors between 2 groups (P > 0.05). The ratio of watertight closure, incision healing, and relative complications were compared between 2 groups.
  
  
  RESULTS
  All patients in 2 groups achieved watertight closure of the dura intraoperatively. There was no significant difference in operation time, intraoperative blood loss, length of dura incision, hospitalization time, total drainage volume, and drainage time between 2 groups (P > 0.05). Primary incision healing was obtained; no delayed healing, infection, or nerve compression occurred in all patients. At last follow-up, the ratios of successful watertight closure of trial and control groups were 89.5% (17/19) and 50.0% (8/16) respectively, showing significant difference (P=0.02). No delayed cerebrospinal fluid leakage or incision infection was found at 1 and 3 months after operation.
  
  
  CONCLUSIONS
  The application of cyanoacrylates for watertight closure of dura in spinal subdural benign tumorectomy is safe and effective.
authors.forename: Miao
authors.initials: M
authors.lastname: Yu
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Jiang
authors.forename: Zhensong
authors.initials: Z
authors.lastname: Yao
authors.forename: Hong
authors.initials: H
authors.lastname: Zhuang
authors.forename: De
authors.initials: D
authors.lastname: Liang
authors.forename: Jinyong
authors.initials: J
authors.lastname: Ding
authors.forename: Shuncong
authors.initials: S
authors.lastname: Zhang
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Tang
authors.forename: Runlin
authors.initials: R
authors.lastname: Xing
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D065634:Cerebrospinal Fluid Leak; D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology / Q000517:prevention & control*; D003487:Cyanoacrylates / Q000008:administration & dosage* / Q000627:therapeutic use; D004388:Dura Mater / Q000601:surgery*; D005260:Female; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000601:surgery*; D013536:Suture Techniques; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D003487:Cyanoacrylates