title: Safety of platelet transfusion: past, present and future.
abstract: Platelet components became routinely available to many institutions in the late 1960s and since then utilization has steadily increased. Platelets are produced by three principal methods and their manufacturing process is regulated by multiple agencies. As the field of platelet transfusion has evolved, a broad array of strategies to improve platelet safety has developed. This review will explore the evolution of modern platelet component therapy, highlight the various risks associated with platelet transfusion and describe risk reduction strategies that have been implemented to improve platelet transfusion safety. In closing, the reader will be briefly introduced to select investigational platelet and platelet-mimetic products that have the potential to enhance platelet transfusion safety in the near future.
authors.affiliation: Department of Pathology, Transfusion Medicine Service, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Katus
authors.forename: Z M
authors.initials: ZM
authors.lastname: Szczepiorkowski
authors.forename: L J
authors.initials: LJ
authors.lastname: Dumont
authors.forename: N M
authors.initials: NM
authors.lastname: Dunbar
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology; D016470:Bacteremia / Q000209:etiology; D001787:Blood Group Incompatibility / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology / Q000382:microbiology; D006801:Humans; D017713:Platelet Transfusion / Q000009:adverse effects*; D012306:Risk; D012769:Shock / Q000209:etiology
keywords: blood collection; platelet concentrates; platelet transfusion; transfusion medicine; transfusion reactions; transfusion-transmissible infections