title: Seeing the forest for the trees: kidney oncogenomes in relation to therapeutic outcomes.
abstract: Renal cell carcinoma is a heterogeneous disease, and tissue investigations provide clues that may predict treatment response. Oncogenomic analysis of five outliers, who achieved a sustained response with rapalogs, implicates alterations of the TSC1 and mTOR genes and reveals insights into the conserved evolution of tumors.
authors.affiliation: Authors' Affiliation: Division of Hematology and Oncology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.
authors.forename: David D
authors.initials: DD
authors.lastname: Chism
authors.forename: W Kimryn
authors.initials: WK
authors.lastname: Rathmell
mesh_terms: D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D008297:Male; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage*; D058570:TOR Serine-Threonine Kinases / Q000096:biosynthesis*
chemical_list: D047428:Protein Kinase Inhibitors; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases