title: [Cardiac potassium channels: molecular structure, physiology, pathophysiology and therapeutic implications].
abstract: Potassium channels and currents play essential roles in cardiac repolarization. Potassium channel blockade by class III antiarrhythmic drugs prolongs cardiac repolarization and results in termination and prevention of cardiac arrhythmias. Excessive inhomogeneous repolarization prolongation may lead to electrical instability and proarrhythmia (Torsade de Pointes tachycardia). This review focuses on molecular structure, physiology, pathophysiology and therapeutic potential of potassium channels of cardiac conduction system and myocardium providing information on recent findings in pathogenesis of cardiac arrhythmias, including inherited genetic abnormalities, and future perspectives.
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Mironov
authors.forename: S P
authors.initials: SP
authors.lastname: Golitsyn
mesh_terms: D000818:Animals; D004562:Electrocardiography; D006329:Heart Conduction System / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D015394:Molecular Structure; D026902:Potassium Channel Blockers / Q000627:therapeutic use*; D015221:Potassium Channels / Q000737:chemistry* / Q000235:genetics; D011379:Prognosis; D016171:Torsades de Pointes / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology
chemical_list: D026902:Potassium Channel Blockers; D015221:Potassium Channels