title: Cardiovascular effects of statins, beyond lipid-lowering properties.
abstract: The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, better known as 'statins', are amongst the most widely used medications in the world. They have become a pivotal component in the primary and secondary prevention of coronary artery and vascular disease. However, a growing amount of evidence has suggested that statins also possess strong pleiotropic effects irrespective of their lipid-lowering properties, which include enhancement of endothelial function, anti-inflammatory and anti-atherothrombotic properties, and immunomodulation. The following provides a comprehensive and updated review of the clinical evidence regarding the pleiotropic effects of statins in cardiovascular disorders and their potential therapeutic benefits.
authors.affiliation: Columbia University, Division of Cardiology at the Mount Sinai Heart Institute, Miami Beach, FL, United States.
authors.forename: Christos G
authors.initials: CG
authors.lastname: Mihos
authors.affiliation: Columbia University, Division of Cardiology at the Mount Sinai Heart Institute, Miami Beach, FL, United States.
authors.forename: Andres M
authors.initials: AM
authors.lastname: Pineda
authors.affiliation: Columbia University, Division of Cardiology at the Mount Sinai Heart Institute, Miami Beach, FL, United States. Electronic address: osantana@msmc.com.
authors.forename: Orlando
authors.initials: O
authors.lastname: Santana
mesh_terms: D002561:Cerebrovascular Disorders / Q000188:drug therapy; D006331:Heart Diseases / Q000188:drug therapy; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy; D058729:Peripheral Arterial Disease / Q000188:drug therapy
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors; Cardiovascular disorders; Pleiotropic effects; Statins