title: Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice.
abstract: Transcranial focused ultrasound (FUS) and microbubble contrast agent, applied at parameters known to transiently increase blood-brain barrier permeability, were tested for the potential to stimulate hippocampal neurogenesis. In adult mice, FUS treatment significantly increased the number of proliferating cells and newborn neurons in the dentate gyrus of the dorsal hippocampus. This provides evidence that FUS with microbubbles can stimulate hippocampal neurogenesis, a process involved in learning and memory and affected in neurological disorders, such as Alzheimer's disease.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Scarcelli
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
authors.forename: Jessica F
authors.initials: JF
authors.lastname: Jordão
authors.affiliation: Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
authors.forename: Meaghan A
authors.initials: MA
authors.lastname: O'Reilly
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Ellens
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada. Electronic address: khynynen@sri.utoronto.ca.
authors.forename: Kullervo
authors.initials: K
authors.lastname: Hynynen
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada. Electronic address: isabelle.aubert@sri.utoronto.ca.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Aubert
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology; D051379:Mice; D045423:Microbubbles; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D014463:Ultrasonography / Q000379:methods*
keywords: Astrogenesis; Cell proliferation; Focused ultrasound; Hippocampus; Neurogenesis