title: Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction.
abstract: BACKGROUND
  The importance of achieving complete revascularization by percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (MI) on exercise capacity remains unclear.
  
  
  OBJECTIVE
  To compare exercise capacity early after acute ST-elevation myocardial infarction (STEMI), in patients receiving PCI with stenting, between those completely revascularized (CR) and those incompletely revascularized (IR).
  
  
  METHODS
  We retrospectively reviewed 326 patients [single-vessel disease (SVD) group, 118 patients; multivessel disease (MVD) with CR group, 112 patients; MVD with IR group, 96 patients] who underwent cardiopulmonary exercise testing 7-30 days after STEMI to measure peak oxygen uptake (VO2peak), oxygen uptake at anaerobic threshold (VO2AT), and peak oxygen pulse. Demographic data, presence of concomitant diseases, STEMI characteristics, and echocardiography and angiography findings were evaluated.
  
  
  RESULTS
  Most patients were male (89.0%) and mean age was 55.6 ± 11.2 years. Ischemic ST deviation occurred in 7.1%, with no significant difference between groups. VO2peak and VO2AT did not differ significantly between groups, despite a trend to be lower in the CR and IR groups compared with the SVD group. Peak oxygen pulse was significantly higher in the SVD group than in the IR group (p = 0.005). After adjustment for age, gender, body mass index, cardiovascular risk factors, MI characteristics and echocardiography parameters, CR was not an independent predictor of VO2peak (OR = -0.123, 95% confidence interval [CI] -2.986 to 0.232, p = 0.093), VO2AT (OR = 0.002, 95% CI 1.735 to 1.773, p = 0.983), or peak oxygen pulse (OR = -0.102, 95% CI -1.435 to 0.105, p = 0.090).
  
  
  CONCLUSIONS
  CR in patients with STEMI treated with PCI for multivessel disease might show no benefit on short-term exercise tolerance over IR.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Jin
authors.initials: J
authors.lastname: Bai
authors.forename: Fuchun
authors.initials: F
authors.lastname: Zhang
authors.forename: Lijun
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China. weigao@bjmu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery*; D010100:Oxygen / Q000378:metabolism*; D062645:Percutaneous Coronary Intervention; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D010100:Oxygen