title: Alteration in synaptic junction proteins following traumatic brain injury.
abstract: Extensive research and scientific efforts have been focused on the elucidation of the pathobiology of cellular and axonal damage following traumatic brain injury (TBI). Conversely, few studies have specifically addressed the issue of synaptic dysfunction. Synaptic junction proteins may be involved in post-TBI alterations, leading to synaptic loss or disrupted plasticity. A Synapse Protein Database on synapse ontology identified 109 domains implicated in synaptic activities and over 5000 proteins, but few of these demonstrated to play a role in the synaptic dysfunction after TBI. These proteins are involved in neuroplasticity and neuromodulation and, most importantly, may be used as novel neuronal markers of TBI for specific intervention.
authors.affiliation: 1 Department of Neurosciences, University of Messina , Messina, Italy .
authors.forename: Lucia
authors.initials: L
authors.lastname: Merlo
authors.forename: Francesco
authors.initials: F
authors.lastname: Cimino
authors.forename: Filippo Flavio
authors.initials: FF
authors.lastname: Angileri
authors.forename: Domenico
authors.initials: D
authors.lastname: La Torre
authors.forename: Alfredo
authors.initials: A
authors.lastname: Conti
authors.forename: Salvatore Massimiliano
authors.initials: SM
authors.lastname: Cardali
authors.forename: Antonella
authors.initials: A
authors.lastname: Saija
authors.forename: Antonino
authors.initials: A
authors.lastname: Germanò
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D013569:Synapses / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins
keywords: neuroproteomic; synaptic dysfunction; synaptic junction proteins; traumatic brain injury