title: Cognitive, neuropsychiatric, and motor features associated with apolipoprotein E ε4 allele in a sample of Bulgarian patients with late-onset Parkinson's disease.
abstract: OBJECTIVE
  To evaluate the role of apolipoprotein E (APOE) ε4 allele on cognitive, neuropsychiatric, and motor features in a sample of Bulgarian patients with late-onset Parkinson's disease (LOPD, age at onset > 55 years).
  
  
  METHODS
  A total of 16 patients with LOPD having APOE ε3/ε4 genotype were compared to 30 patients with LOPD having APOE ε3/ε3 genotype and 20 healthy control individuals. Detailed cognitive assessment and evaluation of neuropsychiatric and motor symptoms were performed.
  
  
  RESULTS
  The patients with LOPD had significantly lower scores in all cognitive domains compared to controls. The patients with LOPD carrying an ε4 allele showed some significant differences in their cognitive, motor, and neuropsychiatric features.
  
  
  CONCLUSIONS
  The data suggest a role of the APOE genotype as a disease-modifying factor.
authors.affiliation: Clinic of Neurology, University Hospital Alexandrovska, Sofia, Bulgaria r1312@abv.bg.
authors.forename: Radka
authors.initials: R
authors.lastname: Pavlova
authors.affiliation: Clinic of Neurology, University Hospital Alexandrovska, Sofia, Bulgaria.
authors.forename: Shima
authors.initials: S
authors.lastname: Mehrabian
authors.affiliation: Clinic of Neurology, University Hospital Alexandrovska, Sofia, Bulgaria.
authors.forename: Maria
authors.initials: M
authors.lastname: Petrova
authors.affiliation: Clinic of Neurology, University Hospital Alexandrovska, Sofia, Bulgaria.
authors.forename: Silvia
authors.initials: S
authors.lastname: Skelina
authors.affiliation: Department of Medical Chemistry and Biochemistry, Molecular Medicine Centre, Medical University, Sofia, Bulgaria.
authors.forename: Kalina
authors.initials: K
authors.lastname: Mihova
authors.affiliation: Department of Medical Chemistry and Biochemistry, Molecular Medicine Centre, Medical University, Sofia, Bulgaria VIB Department of Molecular Genetics, Molecular Neurogenomics Group, University of Antwerp, Antwerpen, Belgium.
authors.forename: Albena
authors.initials: A
authors.lastname: Jordanova
authors.affiliation: Department of Medical Chemistry and Biochemistry, Molecular Medicine Centre, Medical University, Sofia, Bulgaria.
authors.forename: Vanio
authors.initials: V
authors.lastname: Mitev
authors.affiliation: Clinic of Neurology, University Hospital Alexandrovska, Sofia, Bulgaria.
authors.forename: Latchezar
authors.initials: L
authors.lastname: Traykov
mesh_terms: D017668:Age of Onset; D000368:Aged; D000483:Alleles; D053318:Apolipoprotein E3 / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics*; D002031:Bulgaria; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009048:Motor Skills; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D053318:Apolipoprotein E3; D053327:Apolipoprotein E4
keywords:       APOE; LOPD; cognitive; motor; neuropsychiatric; ∊4 allele