title: Association of interleukin-10 polymorphisms with chronic hepatitis C virus infection in a case-control study and its effect on the response to combined pegylated interferon/ribavirin therapy.
abstract: We conducted a case-control study involving 150 genotype 3 chronic hepatitis C virus (HCV) patients and 150 healthy controls to investigate the association of polymorphisms in the interleukin-10 (IL-10) gene with chronic HCV infection and the association of these polymorphic variants with the combination of pegylated interferon (Peg-IFN) and ribavirin therapy response. Our data revealed that the GG genotype of IL-10 -1082A/G exhibited significant association with genotype 3 chronic HCV infection compared to controls. Treatment response data also showed a significant increase in risk for the GG genotype of IL-10 -1082A/G in response-relapse patients or non-responder patients compared to sustained virological response patients. Further, a significant increase in risk was also revealed for the CC genotype of IL-10 -592A/C in response-relapse patients or non-responder patients compared to sustained virological response patients, suggesting a role of the GG genotype of IL-10 -1082A/G and CC genotype of IL-10 -592A/C in the treatment outcome of combined Peg-IFN/ribavirin therapy.
authors.affiliation: Department of Gastroenterology,Sanjay Gandhi Post Graduate Institute of Medical Science,Lucknow, UP,India.
authors.forename: A J
authors.initials: AJ
authors.lastname: Khan
authors.affiliation: Department of Gastroenterology,Sanjay Gandhi Post Graduate Institute of Medical Science,Lucknow, UP,India.
authors.forename: V A
authors.initials: VA
authors.lastname: Saraswat
authors.affiliation: Department of Gastroenterology and Hepato-biliary Sciences at Fortis Memorial Research Institute, Haryana,India.
authors.forename: G
authors.initials: G
authors.lastname: Choudhuri
authors.affiliation: Developmental Toxicology Division, Indian Institute of Toxicology Research,CSIR,Lucknow, UP,India.
authors.forename: D
authors.initials: D
authors.lastname: Parmar
authors.affiliation: Department of Gastroenterology,Sanjay Gandhi Post Graduate Institute of Medical Science,Lucknow, UP,India.
authors.forename: T S
authors.initials: TS
authors.lastname: Negi
authors.affiliation: Department of Gastroenterology,Sanjay Gandhi Post Graduate Institute of Medical Science,Lucknow, UP,India.
authors.forename: S
authors.initials: S
authors.lastname: Mohindra
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000235:genetics* / Q000276:immunology / Q000821:virology; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012254:Ribavirin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: C508609:IL10 protein, human; D016898:Interferon-alpha; D016753:Interleukin-10; D012254:Ribavirin