title: Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival.
abstract: OBJECTIVE
  To investigate the relationship between gender differences in fatty acid-binding protein7 (FABP7) and BRN2 (POU class 3 homeobox 2) expression in renal cell carcinoma (RCC) and the prognosis of patients with RCC.
  
  
  METHODS
  immunohistochemical (IHC) staining as well as reverse transcription-polymerase chain reaction (RT-PCR) was performed in renal tissues from 103 patients (83 men, mean age = 63.6 years old; 20 women, mean age = 63.1 years old) underwent radical nephrectomy from January 1, 2001 through December 31, 2010. The probability of overall patient survival was estimated using the Kaplan-Meier method.
  
  
  RESULTS
  FABP7 mRNA expression was more frequent in men (P = 0.07) while BRN2 protein expression was significantly more frequent in women (P = 0.029). In particular, FABP7 was expressed in 100% of G1 renal cell carcinoma both in mRNA and protein levels. In women, FABP7 (-) and BRN2 (+) groups had a worse prognosis both in mRNA level (P = 0.038) and protein level (P = 0.058). BRN2 was expressed 100% of papillary RCC both in mRNA and protein levels.
  
  
  CONCLUSIONS
  Our results demonstrated that gender was a key factor in FABP7 and BRN2 expression in RCC, and the combination with FABP7 and BRN2 stratified by gender could be a new potential prognostic factor in patients with RCC.
authors.affiliation: Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors.forename: Cheng
authors.initials: C
authors.lastname: Tan
authors.affiliation: Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Takayama
authors.affiliation: Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors.forename: Naohisa
authors.initials: N
authors.lastname: Takaoka
authors.affiliation: Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Fujita
authors.affiliation: Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Miyazaki
authors.affiliation: Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sugiyama
authors.affiliation: Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Ozono
keywords: BRN2; FABP7; gender; overall survival; renal cell carcinoma