title: Coronary artery disease. A study of three polymorphic sites of adenosine deaminase gene.
abstract: OBJECTIVE
  The role of adenosine as a cardioprotective agent is well known and recent experimental studies suggest that impairment of adenosine-related signal transduction contributes to the pathophysiology of chronic heart failure. The recent observation of an association between ADA, genetic polymorphism and coronary artery disease (CAD) prompted us to study the possible relevance of three intragenic polymorphic sites of the ADA gene (ADA1, ADA2 and ADA6).
  
  
  RESULTS
  136 non-diabetic patients with coronary artery disease and 246 healthy blood donors from the white Italian population of Central Italy and 129 non-diabetic patients with CAD and 204 newborns from the white Polish population were studied. ADA1, ADA2 and ADA6 genotypes were determined by DNA analysis. In males, the proportion of ADA1 *2 (P = 0.0001) and ADA2 *2 (P = 0.005) alleles is lower in CAD than in controls. In males, the haplotype distribution of the pairs ADA1-ADA2, ADA1-ADA6 and ADA2-ADA6 shows statistically significant differences between coronary artery disease and controls.
  
  
  CONCLUSIONS
  The present study suggests a complex association between ADA gene and coronary artery diseases. Besides the control of adenosine concentration due to deamination of adenosine, also other functions of the ADA gene could have a role in the susceptibility and/ or clinical course of coronary artery disease.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Saccucci
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Binczak-Kuleta
authors.forename: Maria
authors.initials: M
authors.lastname: Banci
authors.forename: Maja
authors.initials: M
authors.lastname: Krzysztalowska
authors.forename: Alessandro
authors.initials: A
authors.lastname: Dofcaci
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.forename: Andrea
authors.initials: A
authors.lastname: Magrini
authors.forename: Beata
authors.initials: B
authors.lastname: Loniewska
authors.forename: Zdzislawa
authors.initials: Z
authors.lastname: Kornacewicz-Jach
authors.forename: Dariusz
authors.initials: D
authors.lastname: Chlubek
authors.forename: Egidio
authors.initials: E
authors.lastname: Bottini
authors.forename: Andrzej
authors.initials: A
authors.lastname: Ciechanowicz
authors.forename: Fulvia
authors.initials: F
authors.lastname: Gloria-Bottini
mesh_terms: D000243:Adenosine Deaminase / Q000235:genetics*; D000368:Aged; D003324:Coronary Artery Disease / Q000208:ethnology / Q000235:genetics; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D007558:Italy / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000208:ethnology; D011110:Polymorphism, Genetic; D012737:Sex Factors
chemical_list: D000243:Adenosine Deaminase