title: Influence of the programmed cell death of lymphocytes on the immunity of patients with atopic bronchial asthma.
abstract: BACKGROUND
  Fairly recent data highlight the role of programmed cell death and autoimmunity, as potentially important factors in the pathogenesis of chronic obstructive airway diseases. The purpose of our research was to determine the influence of apoptotic factors on the immunity of patients with atopic bronchial asthma according to the degree of severity.
  
  
  METHODS
  The study was performed on the peripheral blood of patients with atopic bronchial asthma with different severity. The Immunological aspects were determined with ELISA, the fluorimetric method and the method of precipitation with polyethylene glycol. And the quantification of the parameters of the programmed cell death was performed by the method of flow cytometry and electron microscopy method.
  
  
  RESULTS
  The data obtained from morphological and biochemical parameters show the deregulation of Programmed Death of lymphocytes of patients with atopic bronchial asthma but individual for each group of patients. This dysfunction might induce the secretion of autoantibodies against DNA. This could explain the accumulation of circulating immune complex with average size considered as the most pathogenic in patients with bronchial asthma especially in the patients of serious severity. It should be noted that Patients with bronchial asthma of mild and severe severity had different way and did not have the same degree of deficiency of the immune system.
  
  
  CONCLUSIONS
  These data suggested that apoptotic factor of lymphocytes may play an important role in controlling immunity of patients with atopic bronchial asthma.
authors.affiliation: Laboratory Acid Nucleic, Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU-Russian), Kremlyovskaya str, 18, Kazan 480008, Republic of Tatarstan, Russian Fédération. sweetiebj@yahoo.fr.
authors.forename: Cyrille Alode
authors.initials: CA
authors.lastname: Vodounon
authors.forename: Christophe Boni
authors.initials: CB
authors.lastname: Chabi
authors.forename: Ylia Valerevna
authors.initials: YV
authors.lastname: Skibo
authors.forename: Vincent
authors.initials: V
authors.lastname: Ezin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Aikou
authors.forename: Simeon Oloni
authors.initials: SO
authors.lastname: Kotchoni
authors.forename: Simon Ayeleroun
authors.initials: SA
authors.lastname: Akpona
authors.forename: Lamine
authors.initials: L
authors.lastname: Baba-Moussa
authors.forename: Zinaida Ivanovna
authors.initials: ZI
authors.lastname: Abramova