title: Protective effects of crocin against streptozotocin-induced oxidative damage in rat striatum.
abstract: The study aimed to investigate the protective effects of crocin (Cro) against streptozotocin (STZ)-induced oxidative damage in rat striatum. Animals were randomly divided into four groups (five each). Group 1 (sham) were treated with normal saline (2 ml/kg, p.o.). Group 2 (STZ-lesioned or lesion) were injected with ICV-STZ (3 mg/kg bilaterally, on day 1 and 3) and treated with normal saline (2 ml/kg, p.o.) respectively, for 21 days. Group 3 (sham+Cro) were injected ICV on day 1 and 3 with artificial CSF and treated with crocin (100 mg/kg, p.o.) for 21 days. Group 4 (lesion+Cro) were injected with ICV STZ (3 mg/kg bilaterally, on day 1 and 3) and treated with crocin (100 mg/kg, p.o.) for 21 days. The homogenized striatum was used for measuring malondialdehyde (MDA), and total thiol contents besides glutathione peroxidase (GPx) activity. Crocin treatment resulted in a significant reduction in MDA concentration as compared to the STZ-lesioned rats. Moreover, crocin produced a significant elevation in total thiol content and GPx activity, as compared with STZ-lesioned group. The present findings provide evidence that crocin may have a therapeutic significance for neurodegenerative diseases such as Alzheimer's disease (AD).
authors.affiliation: Department of Pharmacology, Physiology and Pain Research Centers, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran. mansouri-m@ajums.ac.ir.
authors.forename: Bahareh
authors.initials: B
authors.lastname: Naghizadeh
authors.affiliation: Department of Pharmacology, Physiology and Atherosclerosis Research Centers, Jundishapur University of Medical Sciences, Ahvaz, Iran. mansouri-m@ajums.ac.ir.
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Mansouri
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran. mansouri-m@ajums.ac.ir.
authors.forename: Behnam
authors.initials: B
authors.lastname: Ghorbanzadeh
mesh_terms: D000818:Animals; D002338:Carotenoids / Q000008:administration & dosage / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D013438:Sulfhydryl Compounds; D002338:Carotenoids; D008315:Malondialdehyde; D013311:Streptozocin; C029036:crocin; D005979:Glutathione Peroxidase