title: Enhancement of the electrochemical behaviour and biological performance of Ti-25Ta-5Zr alloy by thermo-mechanical processing.
abstract: A new Ti-25Ta-5Zr alloy based only on non-toxic and non-allergic elements was elaborated in as-cast and thermo-mechanical processed, recrystallized states (XRD and SEM) in order to be used as candidate material for implant applications. Its long-term interactions with Ringer-Brown and Ringer solutions of different pH values and its cytocompatibility were determined. The thermo-mechanically processed alloy has nobler electrochemical behaviour than as-cast alloy due to finer microstructure obtained after the applied treatment. Corrosion and ion release rates presented the lowest values for the treated alloy. Nyquist and Bode plots displayed higher impedance values and phase angles for the processed alloy, denoting a more protective passive film. SEM micrographs revealed depositions from solutions that contain calcium, phosphorous and oxygen ions (EDX analysis), namely calcium phosphate. An electric equivalent circuit with two time constants was modelled. Cell culture experiments with MC3T3-E1 pre-osteoblasts demonstrated that thermo-mechanically processed Ti-25Ta-5Zr alloy supports a better cell adhesion and spreading, and enhanced cell proliferation. Altogether, these data indicate that thermo-mechanical treatment endows the alloy with improved anticorrosion and biological performances.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Bucharest, Spl. Independentei, 91-95, 050095 Bucharest, Romania.
authors.forename: Anisoara
authors.initials: A
authors.lastname: Cimpean
authors.affiliation: Department of Electrochemistry and Corrosion, Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Spl. Independentei 202, 060021 Bucharest, Romania.
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Vasilescu
authors.affiliation: Department of Electrochemistry and Corrosion, Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Spl. Independentei 202, 060021 Bucharest, Romania.
authors.forename: Paula
authors.initials: P
authors.lastname: Drob
authors.affiliation: Faculty of Material Science and Engineering, Politehnica University, Spl. Independentei 313, 060042 Bucharest, Romania. Electronic address: ion_cinca@hotmail.com.
authors.forename: Ion
authors.initials: I
authors.lastname: Cinca
authors.affiliation: Department of Electrochemistry and Corrosion, Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Spl. Independentei 202, 060021 Bucharest, Romania.
authors.forename: Cora
authors.initials: C
authors.lastname: Vasilescu
authors.affiliation: Department of Electrochemistry and Corrosion, Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Spl. Independentei 202, 060021 Bucharest, Romania.
authors.forename: Mihai
authors.initials: M
authors.lastname: Anastasescu
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Bucharest, Spl. Independentei, 91-95, 050095 Bucharest, Romania.
authors.forename: Valentina
authors.initials: V
authors.lastname: Mitran
authors.affiliation: Department of Electrochemistry and Corrosion, Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Spl. Independentei 202, 060021 Bucharest, Romania.
authors.forename: Silviu Iulian
authors.initials: SI
authors.lastname: Drob
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D001826:Body Fluids / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003343:Corrosion; D003460:Crystallization; D058266:Dielectric Spectroscopy; D004560:Electricity; D055664:Electrochemical Techniques / Q000379:methods*; D008422:Materials Testing; D055595:Mechanical Phenomena; D051379:Mice; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D012044:Regression Analysis; D012996:Solutions; D013052:Spectrometry, X-Ray Emission; D013635:Tantalum; D013696:Temperature; D014025:Titanium; D014961:X-Ray Diffraction; D015040:Zirconium
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D012996:Solutions; D013635:Tantalum; D015040:Zirconium; D014025:Titanium
keywords: EDX; EIS; In vitro biocompatibility; Long-term corrosion; SEM; Ti–25Ta–5Zr alloy