title: Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention.
abstract: Deguelin is a natural compound of the flavonoid family products isolated fromDerris trifoliataLour. orMundulea sericea(Leguminosae). It exhibited significant anti-tumorigenesis and anti-proliferative activity in various types of cancer bothin vitroandin vivo. Deguelin induced cell apoptosis by blocking anti-apoptotic pathways, such as PI3K-Akt, IKK-IκBα-NF-κB and AMPK-mTOR-survivin, while inhibiting tumor cell propagation and malignant transformation through p27-cyclinE-pRb-E2F1 cell cycle control and HIF-1α-VEGF anti-angiogenic pathways. In pre-clinical trials, deguelin markedly decreased the tumor incidence. These biological findings identified deguelin as a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention and chemotherapy.
authors.affiliation: Institute of Genetic Engineering, Southern Medical University, Tonghe, Guangzhou 510515, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Genetic Engineering, Southern Medical University, Tonghe, Guangzhou 510515, P.R. China.
authors.forename: Wenli
authors.initials: W
authors.lastname: Ma
authors.affiliation: Institute of Genetic Engineering, Southern Medical University, Tonghe, Guangzhou 510515, P.R. China.
authors.forename: Wenling
authors.initials: W
authors.lastname: Zheng
keywords: anti-angiogenesis; anti-tumorigenesis; apoptosis; cell cycle arrest; deguelin