title: Diagnostic challenges of clonal heterogeneity in prostate cancer.
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Haffner
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center; and Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Angelo M
authors.initials: AM
authors.lastname: De Marzo
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Yegnasubramanian
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center; and Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Epstein
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center; and Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD hcarter@jhmi.edu.
authors.forename: H Ballentine
authors.initials: HB
authors.lastname: Carter
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary; D051517:Digital Rectal Examination; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000556:secondary; D015534:Trans-Activators / Q000032:analysis; D000071230:Transcriptional Regulator ERG; D017211:Treatment Failure; D057832:Watchful Waiting / Q000379:methods* / Q000592:standards / Q000639:trends
chemical_list: D014408:Biomarkers, Tumor; C072312:ERG protein, human; D015534:Trans-Activators; D000071230:Transcriptional Regulator ERG; D017430:Prostate-Specific Antigen