title: Epidermal growth factor receptor mutations in Chinese patients with laryngeal squamous cell carcinoma.
abstract: CONCLUSIONS
  The epidermal growth factor receptor (EGFR) mutation is rare in patients with laryngeal squamous cell carcinoma (LSCC) in China.
  
  
  OBJECTIVE
  To determine the incidence of EGFR mutations in patients with LSCC who underwent surgical resection in mainland China.
  
  
  METHODS
  xTAG technology was used to detect the EGFR exon 19, exon 20, and exon 21 mutations in 132 patients with LSCC who underwent surgical treatment in our hospital from 2010 to 2013.
  
  
  RESULTS
  Of the 132 LSCC specimens examined, only 1 specimen was found to be positive for EGFR exon 20 mutation (0.76%). The mutation was p.T790M in exon 20. Two LSCC specimens were positive for EGFR exon 21 mutation (1.52%). The mutation was p.L858R in exon 21. None of the samples was found to be positive for EGFR exon 19 mutation.
authors.affiliation: Department of Otolaryngology, Affiliated Union Hospital of Fujian Medical University , Fujian, Fuzhou , China.
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Wang
authors.forename: Hai-Chun
authors.initials: HC
authors.lastname: Lai
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002681:China; D015331:Cohort Studies; D066246:ErbB Receptors / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*
chemical_list: D066246:ErbB Receptors
keywords: EGFR; LSCC; gene mutation; xTAG technology