title: Drosophila USP5 controls the activation of apoptosis and the Jun N-terminal kinase pathway during eye development.
abstract: The Jun N-terminal kinase pathway plays an important role in inducing programmed cell death (apoptosis) and is activated in a variety of contexts. The deubiquitinating enzymes (DUBs) are proteases regulating the protein stability by ubiquitin-proteasome system. Here, for the first time, we report the phenotypes observed during eye development that are induced by deleting Drosophila USP5 gene, which encodes one of the USP subfamily of DUBs. usp5 mutants displayed defects in photoreceptor differentiation. Using genetic epistasis analysis and molecular markers, we show that most of these phenotypes are caused by the activation of apoptosis and JNK pathway. These data may provide a mechanistic model for understanding the mammalian usp5 gene.
authors.affiliation: School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Fan
authors.affiliation: School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Qinzhu
authors.initials: Q
authors.lastname: Huang
authors.affiliation: School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Ye
authors.affiliation: School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lin
authors.affiliation: School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Chen
authors.affiliation: School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Lin
authors.affiliation: School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Qu
mesh_terms: D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D054910:Compound Eye, Arthropod / Q000166:cytology / Q000201:enzymology* / Q000254:growth & development; D029721:Drosophila Proteins / Q000502:physiology*; D004331:Drosophila melanogaster / Q000166:cytology / Q000201:enzymology* / Q000254:growth & development; D055786:Gene Knockout Techniques; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D020935:MAP Kinase Signaling System; D017956:Photoreceptor Cells, Invertebrate / Q000502:physiology; D025821:Polyubiquitin / Q000378:metabolism; D064570:Ubiquitin-Specific Proteases / Q000502:physiology*; D054875:Ubiquitination
chemical_list: D029721:Drosophila Proteins; D025821:Polyubiquitin; D048031:JNK Mitogen-Activated Protein Kinases; C000593006:USP5 protein, Drosophila; D064570:Ubiquitin-Specific Proteases