title: Comparison of different morphological parameters with duration of obstruction created experimentally in unilateral upper ureters: an animal model.
abstract: BACKGROUND
  The objective of the following study is to determine and to compare the different morphological parameters with duration of obstruction created experimentally in unilateral upper ureters of rats.
  
  
  METHODS
  Unilateral upper ureteric obstruction was created in 60 adult Wistar rats that were reversed after predetermined intervals. Rats were sacrificed and ipsilateral kidneys were subjected for analysis of morphological parameters such as renal height, cranio-caudal diameter, antero-posterior diameter, lateral diameter, volume of the pelvis and average cortical thickness: Renal height.
  
  
  RESULTS
  Renal height and cranio-caudal diameter of renal pelvis after ipsilateral upper ureteric obstruction started rising as early as 7 days of creating obstruction and were affected earlier than antero-posterior and lateral diameter and also were reversed earlier than other parameters after reversal of obstruction. Renal cortical thickness and volume of the pelvis were affected after prolonged obstruction (> 3 weeks) and were the late parameters to be reversed after reversal of obstruction.
  
  
  CONCLUSIONS
  Cranio-caudal diameter and renal height were the early morphological parameters to be affected and reversed after reversal of obstruction in experimentally created ipsilateral upper ureteric obstruction.
authors.forename: Shasanka Shekhar
authors.initials: SS
authors.lastname: Panda
authors.affiliation: Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Minu
authors.initials: M
authors.lastname: Bajpai
authors.forename: Saumyaranjan
authors.initials: S
authors.lastname: Mallick
authors.forename: Mehar C
authors.initials: MC
authors.lastname: Sharma
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005500:Follow-Up Studies; D007668:Kidney / Q000473:pathology; D007682:Kidney Pelvis / Q000473:pathology*; D011446:Prospective Studies; D051381:Rats; D017208:Rats, Wistar; D014513:Ureter / Q000473:pathology*; D014517:Ureteral Obstruction / Q000175:diagnosis*