title: Aurora kinase inhibitors: Potential molecular-targeted drugs for gynecologic malignant tumors.
abstract: Chemotherapy and surgery are important treatment strategies for gynecologic malignant tumors such as ovarian, cervical and endometrial cancer. However, many anticancer drugs currently available are cytotoxic and cause strong adverse reactions in patients. Aurora kinases have attracted increasing attention in recent years as serine/threonine kinases with various roles in cell division, including chromosomal agglutination and segregation, functions of centromeres, centrosomal maturation, spindle formation and cytokinesis. Aurora kinases are overexpressed in a number of cancers and recent studies have shown that they are involved in onco genesis and cause an aberrant increase in centrosome number, emergence of polykaryocytes and failure of cancer inhibition mechanisms. Thus, drugs that inhibit Aurora kinases are likely to exert anticancer effects in various fields, including the gynecologic field. Aurora kinase inhibitors exert antitumor effects in monotherapy and synergistic effects in combination therapy with taxane-based anticancer agents for gynecologic tumors and are likely to increase the efficacy of existing anticancer drugs. Current Aurora kinase inhibitors include ZM447439, Hesperadin, VX-680/MK-0457, AT9283 and Barasertib, and clinical trials are ongoing to verify the effects of these inhibitors.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Umene
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Banno
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Iori
authors.initials: I
authors.lastname: Kisu
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Yanokura
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Nogami
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Tsuji
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Masuda
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Arisa
authors.initials: A
authors.lastname: Ueki
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Yamagami
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nomura
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Tominaga
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Susumu
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
keywords: Aurora kinase A; Aurora kinase inhibitor; VX-680; ZM447439; gynecologic cancer; hesperadin