title: Tumor necrosis factor (TNF)-alpha promoter polymorphisms in ankylosing spondylitis: comment on the article by Ji et al.
abstract: TNF-α promoter polymorphisms may be associated with the severity rather than the susceptibility of AS. Further studies with a large sample size and precise methodology are needed. Interactions may already exist between gene and environment. All of these are helpful to determine the exact mechanisms of TNF-α promoter polymorphisms in AS.
authors.affiliation: Jiaxing Center for Disease Control and Prevention, No. 486, Wen Qiao Road, Jiaxing, 314050, Zhejiang, China.
authors.forename: Zhongwen
authors.initials: Z
authors.lastname: Chen
authors.forename: Rui
authors.initials: R
authors.lastname: Ge
mesh_terms: D005260:Female; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha