title: Comparative effectiveness research in antineoplastic-induced nausea and vomiting control in children.
abstract: Antineoplastic-induced nausea and vomiting (AINV) is one of the most distressing adverse effects experienced by adult and pediatric patients receiving antineoplastic agents. Despite this, evidence of the efficacy and safety of antiemetic interventions in children is limited, and prevention and treatment approaches vary widely between centers. The purpose of this review is: first, to describe the barriers to comparative antiemetic effectiveness research in AINV control in children; second, to highlight limitations of the currently available pediatric AINV evidence; third, to summarize and discuss comparative effectiveness research specific to AINV control in children, with a focus on agents recommended in evidence-based guidelines developed for acute phase AINV control; and finally, to offer guidance regarding future comparative effectiveness research in this field.
authors.affiliation: Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Department of Pharmacy, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada. jacqueline.flank@sickkids.ca.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Flank
authors.forename: L Lee
authors.initials: LL
authors.lastname: Dupuis
mesh_terms: D000293:Adolescent; D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D057186:Comparative Effectiveness Research / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy*; D010372:Pediatrics / Q000379:methods; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents