title: Impact of the lymphadenectomy in high-risk histologic types of endometrial cancer: a matched-pair study.
abstract: OBJECTIVE
  The aim of this study is to assess the impact of lymphadenectomy (LND) on morbidity, survival, and cost for high-risk histologic types of endometrial cancer (EC).
  
  
  METHODS
  We analyzed a multicenter retrospective cohort of 389 women with high-risk histotypes of EC (poor differenced tumors [G3], clear cell, serous papillary, and mixed mesodermal tumors) preoperatively confined to the corpus and diagnosed between 2000 and 2013. All patients underwent hysterectomy and bilateral salpingo-oophorectomy. A matched-pair analysis identified 97 pairs (97 with LDN and 97 without) equal in age, body mass index, comorbidities, International Federation of Gynecology and Obstetrics stage, and adjuvant treatment. Demographic data, pathologic examination results, perioperative morbidity, and survival were abstracted from medical records. Cost was provided by the cost unit of the local hospital. Disease-free and overall survival were analyzed using the Kaplan-Meier curves and Cox multivariable regression analysis.
  
  
  RESULTS
  Both study groups were homogeneous in demographic data and pathologic examination results. At a median follow-up of 24.5 months (range, 5.4-146.3), disease-free survival (hazard ratio, 1.09; 95% confidence interval, 0.70-1.90) and overall survival (hazard ratio, 0.86; 95% confidence interval, 0.56-1.33) were similar in both groups regardless of nodal count. Positive nodes were found in 23.7%. Predictor factors of nodal involvement were advanced age (P = 0.024), deep myometrial invasion (P < 0.001), and high CA 125 levels (P = 0.003). In the LDN group, operating time, late postoperative complications, and surgical cost were higher (P < 0.05). There were no statistical differences between both groups relative to surgical morbidity. Early postoperative complications and hospital stay were lower in the LDN group. The global cost was similar for both groups (6027&OV0556; for the LND group and 5772&OV0556; for the no-LND group).
  
  
  CONCLUSIONS
  Lymphadenectomy in high-risk histotypes of EC does not increase perioperative morbidity or global cost and has not benefit on survival.
authors.affiliation: *Department of Obstetrics and Gynecology, Hospital Clínico San Carlos, Complutense University of Madrid, Madrid; †Servicio de Obstetricia y Ginecología, Hospital Sanitas La Zarzuela, Madrid; ‡Servicio de Obstetricia y Ginecología, Hospital Miguel Servet, Zaragoza; §Servicio de Obstetricia y Ginecología, Hospital Virgen del Rocio, Sevilla; and ∥Servicio de Oncología Médica, Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Pluvio J
authors.initials: PJ
authors.lastname: Coronado
authors.forename: María
authors.initials: M
authors.lastname: Fasero
authors.forename: Laura
authors.initials: L
authors.lastname: Baquedano
authors.forename: Maria A
authors.initials: MA
authors.lastname: Martinez-Maestre
authors.forename: Antonio
authors.initials: A
authors.lastname: Casado
authors.forename: Jose A
authors.initials: JA
authors.lastname: Vidart
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Herraiz
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D018284:Cystadenocarcinoma, Serous / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009367:Neoplasm Staging; D010052:Ovariectomy; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate