title: [Association of GSTM1 and GSTT1 polymorphisms with noise-induced hearing loss: a meta-analysis].
abstract: OBJECTIVE
  To evaluate the association of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) polymorphisms with noise-induced hearing loss.
  
  
  METHODS
  The Cochrane library, PubMed, OVID, EMBASE, Springer, Wanfang Data, VIP, CNKI, and CBM were searched to collect case-control studies on GSTM1 or GSTT1 polymorphism and noise-induced hearing loss. The articles meeting the inclusion criteria were reviewed systematically, and the reported data were aggregated using Revman 5.0.
  
  
  RESULTS
  Five studies were included in the meta-analysis. The meta-analysis and subgroup analysis showed that the persons with GSTM1 null genotype had an increased risk of noise-induced hearing loss compared with those with GSTM1 wild genotype (OR = 1.37, 95%CI: 1.13∼1.66); in the Chinese population, the risk of noise-induced hearing loss was higher in persons with GSTM1 null genotype than in those with GSTM1 wild genotype (OR = 1.5, 95%CI: 1.2∼1.86); there was no significant difference in the risk of noise-induced hearing loss between persons with GSTT1 null and wild genotypes.
  
  
  CONCLUSIONS
  GSTM1 polymorphism is related to noise-induced hearing loss, but GSTT1 polymorphism is unrelated to this condition.
authors.affiliation: Hefei Prevention and Treatment Center for Occupational Diseases, Hefei 230001, China.
authors.forename: Sijing
authors.initials: S
authors.lastname: Zhou
authors.affiliation: E-mail: ranwang2005@126.com.
authors.forename: Ran
authors.initials: R
authors.lastname: Wang
authors.forename: Junsheng
authors.initials: J
authors.lastname: Zhou
authors.forename: Shengping
authors.initials: S
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Lei
authors.initials: L
authors.lastname: Cao
mesh_terms: D005982:Glutathione Transferase / Q000235:genetics*; D006317:Hearing Loss, Noise-Induced / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1