title: Association between ghrelin gene variations, body mass index, and waist-to-hip ratio in patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate the association between 2 single nucleotide polymorphisms (SNP501A/C and 604 G/A) in the promoter of the ghrelin gene and the hormonal and metabolic phenotypes of polycystic ovary syndrome (PCOS) in a Chinese population.
  
  
  METHODS
  285 patients with PCOS and 260 healthy controls were selected for a prospective, case-control study at Shandong Provincial Hospital, Jinan, China. All subjects underwent genotype analysis of the 2 single nucleotide polymorphisms of the ghrelin gene. Measurements were also taken of blood lipids, glucose, and hormone levels, and calculations of body mass index (BMI) and waist-to-hip ratio (WHR) were performed to detect hormonal and metabolic phenotypes.
  
  
  RESULTS
  No significant diff erences in polymorphism genotypes were found between PCOS patients and healthy controls. However, the frequency of the -501 A/C A allele was significantly higher in the PCOS group than in the control group. PCOS -501 A/C A carriers had significantly higher BMI and WHR than PCOS women with the CC genotype. -604 G/A polymorphisms were not associated with clinical or biochemical characteristics of PCOS.
  
  
  CONCLUSIONS
  The -501 A/C polymorphism of the ghrelin gene is associated with metabolic features of PCOS in a Chinese population.
authors.affiliation: Obstetrics and Gynecology Department, The Affiliated Hospital of Qingdao University Medical College, Qingdao, People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.affiliation: Shandong Provincial Key Laboratory of Reproductive Medicine, Center for Reproductive Medicine, Provincial -Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Obstetrics and Gynecology Department, The Affiliated Hospital of Qingdao University Medical College, Qingdao, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Gu
authors.affiliation: Obstetrics and Gynecology Department, The Affiliated Hospital of Qingdao University Medical College, Qingdao, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Central Laboratory, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.affiliation: Shandong Provincial Key Laboratory of Reproductive Medicine, Center for Reproductive Medicine, Provincial -Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: You
authors.affiliation: Obstetrics and Gynecology Department, The Affiliated Hospital of Qingdao University Medical College, Qingdao, People's Republic of China.
authors.forename: X
authors.initials: X
authors.lastname: Qi
authors.affiliation: Obstetrics and Gynecology Department, The Affiliated Hospital of Qingdao University Medical College, Qingdao, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Shandong Provincial Key Laboratory of Reproductive Medicine, Center for Reproductive Medicine, Provincial -Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D015992:Body Mass Index; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D054439:Ghrelin / Q000235:genetics*; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000235:genetics* / Q000473:pathology*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011446:Prospective Studies; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D054439:Ghrelin; D012739:Gonadal Steroid Hormones; D008055:Lipids; D004247:DNA