title: Cardiovascular effects of mild hypothermia in post-cardiac arrest patients by beat-to-beat monitoring. A single centre pilot study.
abstract: BACKGROUND
  Data on the hemodynamic and cardiovascular effects of hypothermia in patients with cardiac arrest are scarce. The aim of this study was to evaluate the hemodynamic changes induced by hypothermia by means of Most Care(®) (pressure recording analytical method, PRAM methodology), a beat-to-beat hemodynamic monitoring method.
  
  
  METHODS
  We enrolled 20 patients with cardiac arrest (CA) consecutively admitted to our intensive cardiac care unit and treated with mild hypothermia (TH).
  
  
  RESULTS
  While non-survivors showed no changes in haemodynamic variables throughout the study period, survivors exhibited a significant increase in systemic vascular resistance indexed during hypothermia and a trend towards lower values of heart rate and higher levels of mean arterial pressure.
  
  
  CONCLUSIONS
  According to our data, PRAM methodology proved to be a feasible and clinically useful tool in CA patients treated with TH since it provides continuous beat-to-beat haemodynamic monitoring that is based on assessment of several haemodynamic variables. Moreover, we observed that survivors showed a different haemodynamic behaviour during hypothermia in respect to patients who died. However, further studies, performed in larger cohorts, are needed to better elucidate the haemodynamic effects of hypothermia in CA patients by means of PRAM methodology.
authors.affiliation: Intensive Cardiac Coronary Unit, Heart and Vessel Department, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Lazzeri
authors.forename: Andrea
authors.initials: A
authors.lastname: Sori
authors.forename: Pasquale
authors.initials: P
authors.lastname: Bernardo
authors.forename: Marco
authors.initials: M
authors.lastname: Chiostri
authors.forename: Eleonora
authors.initials: E
authors.lastname: Tommasi
authors.forename: Mery
authors.initials: M
authors.lastname: Zucchini
authors.forename: Salvatore Mario
authors.initials: SM
authors.lastname: Romano
authors.forename: Gian Franco
authors.initials: GF
authors.lastname: Gensini
authors.forename: Serafina
authors.initials: S
authors.lastname: Valente
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D003128:Coma / Q000150:complications; D005260:Female; D006323:Heart Arrest / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D006339:Heart Rate; D006439:Hemodynamics; D017052:Hospital Mortality; D006801:Humans; D007036:Hypothermia, Induced; D007773:Lactates / Q000097:blood; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D010865:Pilot Projects; D016896:Treatment Outcome; D014655:Vascular Resistance
chemical_list: D001786:Blood Glucose; D007773:Lactates