title: A synergistic capture strategy for enhanced detection and elimination of bacteria.
abstract: Despite the advanced detection and sterilization techniques available today, the sensitive diagnosis and complete elimination of bacterial infections remain a significant challenge. A strategy is reported for efficient bacterial capture (ca. 90%) based on the synergistic effect of the nanotopography and surface chemistry of the substrate on bacterial attachment and adhesion. The outstanding bacterial-capture capability of the functionalized nanostructured substrate enables rapid and highly sensitive bacterial detection down to trace concentrations of pathogenic bacteria (10 colony-forming units mL(-1)). In addition, this synergistic biocapture substrate can be used for efficient bacterial elimination and shows great potential for clinical antibacterial applications.
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (Singapore) http://www.ntu.edu.sg/home/chenxd/
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Li
authors.forename: Bowen
authors.initials: B
authors.lastname: Zhu
authors.forename: Yuangang
authors.initials: Y
authors.lastname: Li
authors.forename: Wan Ru
authors.initials: WR
authors.lastname: Leow
authors.forename: Rubayn
authors.initials: R
authors.lastname: Goh
authors.forename: Bing
authors.initials: B
authors.lastname: Ma
authors.forename: Eileen
authors.initials: E
authors.lastname: Fong
authors.forename: Mark
authors.initials: M
authors.lastname: Tang
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Chen
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D004357:Drug Synergism; D006801:Humans; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods*
keywords: antimicrobial agents; bacterial detection; nanotechnology; silicon; surface chemistry