title: Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: a report from the Children's Oncology Group.
abstract: Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a rare subtype associated with FLT3-internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of paediatric patients with t(6;9) with and without FLT3-ITD treated on six consecutive cooperative trails were evaluated. In contrast to patients without t(6;9), those with t(6;9) had a significantly lower complete remission rate, higher relapse rate (RR), and poor overall survival (OS). Within t(6;9) patients, those with and without FLT3-ITD had an OS of 40% and 27% respectively (P > 0·9), demonstrating that t(6;9) is a high-risk cytogenetic feature in paediatric AML and its clinical impact is independent of the presence of FLT3-ITD.
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.|Department of Pediatrics, University of Washington School of Medicine, Seattle, WA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Tarlock
authors.affiliation: Keck School of Medicine, University of Southern California, Arcadia, CA.|Children's Oncology Group, Arcadia, CA.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Alonzo
authors.affiliation: Hematology and Blood and Marrow Transplant Program, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Pilar Palomo
authors.initials: PP
authors.lastname: Moraleda
authors.affiliation: Children's Oncology Group, Arcadia, CA.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Gerbing
authors.affiliation: Children's Oncology Group, Arcadia, CA.|Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.
authors.forename: Susana C
authors.initials: SC
authors.lastname: Raimondi
authors.affiliation: Children's Oncology Group, Arcadia, CA.|Division of Laboratory Medicine, University of Minnesota Medical Center-Fairview, MN.
authors.forename: Betsy A
authors.initials: BA
authors.lastname: Hirsch
authors.affiliation: Children's Oncology Group, Arcadia, CA.|Carman and Ann Adams Department of Pediatrics, Division of Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI.
authors.forename: Yaddanapudi
authors.initials: Y
authors.lastname: Ravindranath
authors.affiliation: Children's Oncology Group, Arcadia, CA.|Children's Hosp. of Philadelphia, Philadelphia, PA.
authors.forename: Beverly
authors.initials: B
authors.lastname: Lange
authors.affiliation: Children's Oncology Group, Arcadia, CA.|Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta.
authors.forename: William G
authors.initials: WG
authors.lastname: Woods
authors.affiliation: Children's Oncology Group, Arcadia, CA.|Children's Mercy Hospitals and Clinics, Kansas City, MO.
authors.forename: Alan S
authors.initials: AS
authors.lastname: Gamis
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.|Department of Pediatrics, University of Washington School of Medicine, Seattle, WA.|Children's Oncology Group, Arcadia, CA.
authors.forename: Soheil
authors.initials: S
authors.lastname: Meshinchi
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005260:Female; D020440:Gene Duplication; D052138:Genes, Neoplasm; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction; D016019:Survival Analysis; D020080:Tandem Repeat Sequences; D014178:Translocation, Genetic; D016896:Treatment Outcome; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
chemical_list: D009363:Neoplasm Proteins; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3
keywords: FLT3-ITD; acute myeloid leukaemia; clinical outcome; paediatric; t(6; 9)(p23; q34)