title: Molecular characterization of three ferret badger (Melogale moschata) rabies virus isolates from Jiangxi province, China.
abstract: Ferret badger (FB) rabies viruses JX09-17(fb), JX09-18 and JX10-37 were isolated from three different regions in Jiangxi province, China, in 2009 and 2010. The complete nucleotide sequence identity between these three isolates was 87-93 %. Compared with the other Chinese rabies virus isolates and vaccine strains, 101 substitutions (53 in JX10-37, 23 in JX09-17(fb) and 25 in JX09-18) in the five structural proteins were observed, and 47 of these substitutions (27 in JX10-37, 14 in JX09-17(fb) and 6 in JX09-18) were unique among lyssaviruses. Amino acid substitutions of S231 and Q333 were noted respectively in the G protein antigenic site I of JX10-37 and site III in JX09-17(fb). Phylogenetic analysis showed that JX09-17(fb) is rooted within the China I lineage, JX09-18 is in China II, and JX10-37 is independent. Evolutionary analysis and comparative sequence data indicate that isolate JX10-37 is a variant virus that diverged from canine rabies viruses around 1933 (range 1886-1963).
authors.affiliation: Laboratory of Epidemiology and Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute, Academy of Military Medical Sciences, 666 Liuying West Road, Changchun, 130122, People's Republic of China.
authors.forename: Jinghui
authors.initials: J
authors.lastname: Zhao
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.forename: Shoufeng
authors.initials: S
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Lijuan
authors.initials: L
authors.lastname: Mi
authors.forename: Shuchao
authors.initials: S
authors.lastname: Wang
authors.forename: Rongliang
authors.initials: R
authors.lastname: Hu
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000818:Animals; D002681:China; D004283:Dog Diseases / Q000635:transmission / Q000821:virology; D004285:Dogs; D005289:Ferrets / Q000821:virology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D011818:Rabies / Q000662:veterinary* / Q000821:virology; D011820:Rabies virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins