title: Association study between miR-149 gene polymorphism and nasopharyngeal carcinoma.
abstract: Association studies between single-nucleotide polymorphism (SNP) rs2292832 on miR-149 gene and cancer risk have been previously analyzed in several types of cancer. The aim of this study was to evaluate the association between miR-149 polymorphism and risk of nasopharyngeal carcinoma (NPC). miR-149 gene polymorphism was genotyped using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) in 158 patients with NPC and 242 healthy individuals. Associations with cancer risk and clinicopathological characteristics were analyzed by χ2test. No significant difference was observed for miR-149 gene polymorphism in NPC patients and healthy controls in either genotype (P=0.427 for CC vs. CT vs. TT, P=0.247 for CT vs. TT and P=0.323 for CC vs. TT, respectively) or allelic analysis (P=0.216). No significant difference was noted between the genotypes and the clinicopathological parameters examined with the exception of clinical stage. A significantly higher CC distribution in clinical stage I-II compared with III-IV was observed under the dominant model (CC vs. CT vs. TT, P=0.026) and the co-dominant model (CC vs. TT, P=0.030). The results of this study suggested that the CC genotype of miR-149 contributes to the progression and development, rather than the initiation of NPC.
authors.affiliation: Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, Guangdong 523808, P.R. China ; Key Laboratory for Medical Molecular Diagnostics of Guangdong, Dongguan, Guangdong 523808, P.R. China.
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Huang
authors.affiliation: Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, Guangdong 523808, P.R. China ; Key Laboratory for Medical Molecular Diagnostics of Guangdong, Dongguan, Guangdong 523808, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Medical Oncology, Hunan Tumor Hospital, Changsha, Hunan 410006, P.R. China.
authors.forename: Xing-Xiang
authors.initials: XX
authors.lastname: Pu
authors.affiliation: Department of Oncology, Central South University Xiangya Hospital, Changsha, Hunan 410011, P.R. China.
authors.forename: Yu-Xiang
authors.initials: YX
authors.lastname: He
authors.affiliation: Institute of Laboratory Medicine, Guangdong Medical College, Dongguan, Guangdong 523808, P.R. China.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Chen
authors.affiliation: Institute of Laboratory Medicine, Guangdong Medical College, Dongguan, Guangdong 523808, P.R. China.
authors.forename: Ya-Zhen
authors.initials: YZ
authors.lastname: Li
authors.affiliation: Institute of Laboratory Medicine, Guangdong Medical College, Dongguan, Guangdong 523808, P.R. China.
authors.forename: Shu-Yin
authors.initials: SY
authors.lastname: Tang
authors.affiliation: Institute of Laboratory Medicine, Guangdong Medical College, Dongguan, Guangdong 523808, P.R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Che
authors.affiliation: Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, Guangdong 523808, P.R. China ; Key Laboratory for Medical Molecular Diagnostics of Guangdong, Dongguan, Guangdong 523808, P.R. China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: He
keywords: cancer risk; miR-149; nasopharyngeal carcinoma; polymorphism; single-nucleotide polymorphism