title: Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo.
abstract: Poly(vinyl alcohol)/sodium alginate nanofibrous mats were produced by electrospinning method at optimum process parameters. Evaluation of alginate-based electrospun nanofibrous mats as a wound dressing material and their comparison to commercially available wound dressings produced with conventional methods were carried out in vivo. Tissue specimens were examined histopathologically on 4th, 6th, 15th, 21st postoperative days. In contrast to other dressings it was observed that nanofibrous mat could survive on the wound crust in early stages of healing. In terms of epithelization, epidermis characteristics, vascularization and formation of hair follicles, nanofibrous mat showed the best healing performance. This could be explained with presence of nanofibrous mat acting as an artificial skin on the wound region until new tissue regenerated.
authors.affiliation: Graduate School of Natural and Applied Sciences, Uludag University, Bursa, Turkey.
authors.forename: Gökçe
authors.initials: G
authors.lastname: Coşkun
authors.affiliation: Department of Textile Engineering, Uludag University, Bursa, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Karaca
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Uludag University, Bursa, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozyurtlu
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Uludag University, Bursa, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Ozbek
authors.affiliation: Department of Histology and Embryology, Uludag University, Bursa, Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Yermezler
authors.affiliation: Department of Histology and Embryology, Uludag University, Bursa, Turkey.
authors.forename: Ilkin
authors.initials: I
authors.lastname: Cavuşoğlu
mesh_terms: D000464:Alginates / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D020723:Glucuronic Acid / Q000737:chemistry / Q000627:therapeutic use; D006603:Hexuronic Acids / Q000737:chemistry / Q000627:therapeutic use; D008297:Male; D057139:Nanofibers / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D011142:Polyvinyl Alcohol / Q000737:chemistry / Q000627:therapeutic use*; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D011142:Polyvinyl Alcohol
keywords: Electrospinning; alginate; histological evaluation; in vivo; nanofiber; wound dressing