title: Characterization and biological activities of two copper(II) complexes with dipropylenetriamine and diamine as ligands.
abstract: Two new mixed-ligand copper(II) complexes, [Cu(dipn)(NN)]Br2(1-2) [dipn=dipropylenetriamine, NN=ethylenediamine (en) (1) and propylenediamine (pn) (2)], have been synthesized. These complexes were characterized by spectroscopic and thermal techniques. Crystal structure for 2 shows a distorted trigonal-bipyramidal geometry around Cu(II) ion with one solvate water molecule. Antimicrobial and antiproliferative assays were conducted to evaluate the biological activities of these complexes. The complexes exhibit a promising antimicrobial effect against an array of microbes at 200μg/mL concentration. The antiproliferative assay shows a high potential of these complexes to target Human keratinocyte cell line with IC50 values of 155 and 152μM. The absorption spectrum of 2 in water was modeled by time-dependent density functional theory (TD-DFT).
authors.affiliation: Department of Chemistry, Hashemite University, P.O. Box 150459, Zarqa 13115, Jordan. Electronic address: manoaimi@hu.edu.jo.
authors.forename: Mousa
authors.initials: M
authors.lastname: AL-Noaimi
authors.affiliation: Department of Chemistry, Science College, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Mohammad I
authors.initials: MI
authors.lastname: Choudhary
authors.affiliation: Chemistry Department, Faculty of Science, The University of Jordan, Amman 11942, Jordan.
authors.forename: Firas F
authors.initials: FF
authors.lastname: Awwadi
authors.affiliation: Department of Clinical Pharmacy and Therapeutics, Applied Science University, Amman 11931, Jordan.
authors.forename: Wamidh H
authors.initials: WH
authors.lastname: Talib
authors.affiliation: Laboratoire LCM, Faculty of Sciences, University Mohammed 1(ER), Oujda 60000, Morocco.
authors.forename: Taibi Ben
authors.initials: TB
authors.lastname: Hadda
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Sammer
authors.initials: S
authors.lastname: Yousuf
authors.affiliation: Biology and Biotechnology Department, AN-Najah National University, P.O. Box 7, Nablus, Palestine.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Sawafta
authors.affiliation: Department of Chemistry, AN-Najah National University, P.O. Box 7, Nablus, Palestine.
authors.forename: Ismail
authors.initials: I
authors.lastname: Warad
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000254:growth & development*; D049109:Cell Proliferation / Q000187:drug effects*; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003959:Diamines / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007097:Imines / Q000737:chemistry / Q000494:pharmacology; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism*; D015394:Molecular Structure
chemical_list: D000890:Anti-Infective Agents; D003959:Diamines; D007097:Imines; D003300:Copper
keywords: Biological activity; Cu(II) complexes; Polyamine ligands; Single-crystal XRD