title: Chinese herbal medicine Shenqi Detoxification Granule inhibits fibrosis in adenine induced chronic renal failure rats.
abstract: BACKGROUND
  Progressive fibrosis accompanies all chronic renal disease, connective tissue growth factor (CTGF,) and platelet-derived growth factor-B, (PDGF-B,) play important roles in extra-cellular matrix abnormal accumulation, while endothelin-1 (ET-1) nitric oxide (NO,) are related to endothelial dysfunction, which mediates the progression of renal fibrosis. Shenqi Detoxification Granule (SDG), a traditional Chinese herbal formula, has been used for treatment of chronic renal failure in clinic for many years.
  
  
  METHODS
  In order to evaluate the efficacy, and explore the mechanism of SDG to inhibit the progression of renal fibrosis, study was carried out using the adenine-induced Wister rats as the CRF model, and losartan as postive control drug. Levels of serum creatinine [Scr], and blood urea nitrogen (BUN), albumin (ALB), 24hrs, urine protein (24hUP), triacylglycerol (TG), and cholesterol (CHO), together with ET-1, and NO were detected. Pathological changes of renal tissues were observed by HE, staining. In addition, CTGF and PDGF-B expression were analyzed by immuno-histo-chemistry.
  
  
  RESULTS
  The results indicated that SDG can effectively reduce Scr, BUN, 24hUP, TG, and CHO levels, increase ALB levels, inhibit renal tissue damage in CRF rats, and the mechanism maybe reduce PDGF-B, CTGF expression and ET-1/NO.
  
  
  CONCLUSIONS
  Shenqi Detoxification Granule is a beneficial treatment for chronic renal failure.
authors.affiliation: Department of Traditional Chinese Medicine, Provincial Hospital Affiliated to Shandong University, 324, Jinwu Weiqi Road, Ji'nan, 250021, China.
authors.forename: Min
authors.initials: M
authors.lastname: Peng
authors.affiliation: Department of Traditional Chinese Medicine, Provincial Hospital Affiliated to Shandong University, 324, Jinwu Weiqi Road, Ji'nan, 250021, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Cai
authors.affiliation: Department of Traditional Chinese Medicine, Provincial Hospital Affiliated to Shandong University, 324, Jinwu Weiqi Road, Ji'nan, 250021, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Traditional Chinese Medicine, Provincial Hospital Affiliated to Shandong University, 324, Jinwu Weiqi Road, Ji'nan, 250021, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Meng
authors.affiliation: Department of Traditional Chinese Medicine, Provincial Hospital Affiliated to Shandong University, 324, Jinwu Weiqi Road, Ji'nan, 250021, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Traditional Chinese Medicine, Provincial Hospital Affiliated to Shandong University, 324, Jinwu Weiqi Road, Ji'nan, 250021, China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Traditional Chinese Medicine, Provincial Hospital Affiliated to Shandong University, 324, Jinwu Weiqi Road, Ji'nan, 250021, China.
authors.forename: Guomin
authors.initials: G
authors.lastname: Si
mesh_terms: D000225:Adenine; D000418:Albumins / Q000378:metabolism; D000818:Animals; D001806:Blood Urea Nitrogen; D002784:Cholesterol / Q000097:blood; D055513:Connective Tissue Growth Factor / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000378:metabolism; D005355:Fibrosis / Q000517:prevention & control; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D019684:Magnoliopsida; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D008517:Phytotherapy; D020574:Proto-Oncogene Proteins c-sis / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D000418:Albumins; D004365:Drugs, Chinese Herbal; D019332:Endothelin-1; D020574:Proto-Oncogene Proteins c-sis; D014280:Triglycerides; C585913:shenqi; D055513:Connective Tissue Growth Factor; D009569:Nitric Oxide; D002784:Cholesterol; D003404:Creatinine; D000225:Adenine
keywords: CTGF; Chronic Renal Failure; PDGF-B; Shenqi Detoxification Granule; fibrosis