title: Interventricular septal thickening as an early manifestation of cardiac sarcoidosis.
abstract: We report an unusual case of cardiac sarcoidosis demonstrated by interventricular septal thickening. A 64-year-old woman was diagnosed with sarcoidosis involving the lungs, eyes, and skin. Three years later, renal dysfunction was detected during a periodic examination and a renal biopsy revealed non-caseating granulomas. Electrocardiogram results were normal, but an echocardiogram revealed thickening of the interventricular septum. Abnormal accumulation of gallium-67 and a perfusion defect in tecnetium-99-methoxyisobutylisonitrile scintigrams occurred in the interventricular septum. Magnetic resonance images showed T2-high intensity in the lesion. We considered the thickening to represent cardiac involvement of sarcoidosis. Oral prednisolone therapy diminished the interventricular septal thickening.
authors.affiliation: Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Nureki
authors.forename: Eishi
authors.initials: E
authors.lastname: Miyazaki
authors.forename: Suehiro
authors.initials: S
authors.lastname: Nishio
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ehara
authors.forename: Mari
authors.initials: M
authors.lastname: Yamasue
authors.forename: Masaru
authors.initials: M
authors.lastname: Ando
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kadota
mesh_terms: D000284:Administration, Oral; D009202:Cardiomyopathies / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D006984:Hypertrophy / Q000175:diagnosis / Q000188:drug therapy; D019028:Magnetic Resonance Imaging, Cine; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods; D011239:Prednisolone / Q000008:administration & dosage; D012507:Sarcoidosis / Q000175:diagnosis*; D054088:Ventricular Septum / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone