title: A novel radioguided surgery technique exploiting β(-) decays.
abstract: The background induced by the high penetration power of the radiation is the main limiting factor of the current radio-guided surgery (RGS). To partially mitigate it, a RGS with β(+)-emitting radio-tracers has been suggested in literature. Here we propose the use of β(-)-emitting radio-tracers and β(-) probes and discuss the advantage of this method with respect to the previously explored ones: the electron low penetration power allows for simple and versatile probes and could extend RGS to tumours for which background originating from nearby healthy tissue makes probes less effective. We developed a β(-) probe prototype and studied its performances on phantoms. By means of a detailed simulation we have also extrapolated the results to estimate the performances in a realistic case of meningioma, pathology which is going to be our first in-vivo test case. A good sensitivity to residuals down to 0.1 ml can be reached within 1 s with an administered activity smaller than those for PET-scans thus making the radiation exposure to medical personnel negligible.
authors.affiliation: Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Roma, Italy.
authors.forename: E Solfaroli
authors.initials: ES
authors.lastname: Camillocci
authors.affiliation: Dip. Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Baroni
authors.affiliation: 1] Dip. Fisica, Sapienza Univ. di Roma, Roma, Italy [2] INFN Sezione di Roma, Roma, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bellini
authors.affiliation: INFN Sezione di Roma, Roma, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Bocci
authors.affiliation: 1] Dip. Fisica, Sapienza Univ. di Roma, Roma, Italy [2] INFN Sezione di Roma, Roma, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Collamati
authors.affiliation: Div. Fisica Medica, Istituto Europeo di Oncologia, Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cremonesi
authors.affiliation: Laboratori Nazionali di Frascati dell'INFN, Frascati, Italy.
authors.forename: E
authors.initials: E
authors.lastname: De Lucia
authors.affiliation: Fondazione Istituto Neurologico Carlo Besta, Milano, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Ferroli
authors.affiliation: 1] INFN Sezione di Roma, Roma, Italy [2] ENEA UTTMAT-IRR, Casaccia R.C., Roma, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Fiore
authors.affiliation: Div. Medicina Nucleare, Istituto Europeo di Oncologia, Milano, Italy.
authors.forename: C M
authors.initials: CM
authors.lastname: Grana
authors.affiliation: 1] INFN Sezione di Roma, Roma, Italy [2] Museo Storico della Fisica e Centro Studi e Ricerche 'E. Fermi', Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Marafini
authors.affiliation: 1] Dipartimento di Matematica e Fisica, Università Roma Tre, Roma, Italy [2] Laboratori Nazionali di Frascati dell'INFN, Frascati, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Mattei
authors.affiliation: INFN Sezione di Roma, Roma, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Morganti
authors.affiliation: Department of Nuclear Medicine and Radiometabolic Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, IRST-IRCCS, Meldola, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Paganelli
authors.affiliation: 1] INFN Sezione di Roma, Roma, Italy [2] Dip. Scienze di Base e Applicate per l'Ingegneria, Sapienza Univ. di Roma, Roma, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Patera
authors.affiliation: 1] INFN Sezione di Roma, Roma, Italy [2] Dip. Scienze di Base e Applicate per l'Ingegneria, Sapienza Univ. di Roma, Roma, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Piersanti
authors.affiliation: INFN Sezione di Roma, Roma, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Recchia
authors.affiliation: 1] Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Roma, Italy [2] Dip. Fisica, Sapienza Univ. di Roma, Roma, Italy [3] INFN Sezione di Roma, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Russomando
authors.affiliation: Fondazione Istituto Neurologico Carlo Besta, Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Schiariti
authors.affiliation: 1] Laboratori Nazionali di Frascati dell'INFN, Frascati, Italy [2] Dip. Scienze di Base e Applicate per l'Ingegneria, Sapienza Univ. di Roma, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Sarti
authors.affiliation: 1] INFN Sezione di Roma, Roma, Italy [2] Dip. Scienze di Base e Applicate per l'Ingegneria, Sapienza Univ. di Roma, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Sciubba
authors.affiliation: INFN Sezione di Roma, Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Voena
authors.affiliation: 1] Dip. Fisica, Sapienza Univ. di Roma, Roma, Italy [2] INFN Sezione di Roma, Roma, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Faccini
mesh_terms: D001610:Beta Particles; D004583:Electrons; D006801:Humans; D008577:Meningeal Neoplasms / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000473:pathology / Q000601:surgery; D019047:Phantoms, Imaging; D012680:Sensitivity and Specificity; D025321:Surgery, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D059016:Tumor Microenvironment; D015021:Yttrium Radioisotopes
chemical_list: D015021:Yttrium Radioisotopes