title: Nonenzymatic amperometric sensor for ascorbic acid based on hollow gold/ruthenium nanoshells.
abstract: We report a new nonenzymatic amperometric detection of ascorbic acid (AA) using a glassy carbon (GC) disk electrode modified with hollow gold/ruthenium (hAu-Ru) nanoshells, which exhibited decent sensing characteristics. The hAu-Ru nanoshells were prepared by the incorporation of Ru on hollow gold (hAu) nanoshells from Co nanoparticle templates, which enabled AA selectivity against glucose without aid of enzyme or membrane. The structure and electrocatalytic activities of the hAu-Ru catalysts were characterized by spectroscopic and electrochemical techniques. The hAu-Ru loaded on GC electrode (hAu-Ru/GC) showed sensitivity of 426 μA mM(-1) cm(-2) (normalized to the GC disk area) for the linear dynamic range of <5 μM to 2 mM AA at physiological pH. The response time and detection limit were 1.6 s and 2.2 μM, respectively. Furthermore, the hAu-Ru/GC electrode displayed remarkable selectivity for ascorbic acid over all potential biological interferents, including glucose, uric acid (UA), dopamine (DA), 4-acetamidophenol (AP), and nicotinamide adenine dinucleotide (NADH), which could be especially good for biological sensing.
authors.affiliation: Department of Chemistry & Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.
authors.forename: Ara
authors.initials: A
authors.lastname: Jo
authors.affiliation: Department of Chemistry & Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.
authors.forename: Minkyung
authors.initials: M
authors.lastname: Kang
authors.affiliation: Department of Chemistry & Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.
authors.forename: Areum
authors.initials: A
authors.lastname: Cha
authors.affiliation: Department of Chemistry & Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.
authors.forename: Hye Su
authors.initials: HS
authors.lastname: Jang
authors.affiliation: Department of Chemistry, Daegu University, Gyeongsan 712-714, Republic of Korea.
authors.forename: Jun Ho
authors.initials: JH
authors.lastname: Shim
authors.affiliation: National Center for Nanomaterials Technology (NCNT), Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
authors.forename: Nam-Suk
authors.initials: NS
authors.lastname: Lee
authors.affiliation: Department of Chemistry & Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.
authors.forename: Myung Hwa
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Department of Chemistry & Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea. Electronic address: youngmilee@ewha.ac.kr.
authors.forename: Youngmi
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Department of Chemistry & Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea. Electronic address: cmlee@ewha.ac.kr.
authors.forename: Chongmok
authors.initials: C
authors.lastname: Lee
mesh_terms: D001205:Ascorbic Acid / Q000032:analysis*; D002244:Carbon / Q000737:chemistry; D055664:Electrochemical Techniques; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D057145:Nanoshells / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012428:Ruthenium / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D002244:Carbon; D006046:Gold; D012428:Ruthenium; D001205:Ascorbic Acid
keywords: Amperometric sensor; Biosensor; Electrocatalyst; Hollow gold ruthenium; Nonenzymatic ascorbic acid sensor