title: Anticancer properties of Monascus metabolites.
abstract: This review provides up-to-date information on the anticancer properties of Monascus-fermented products. Topics covered include clinical evidence for the anticancer potential of Monascus metabolites, bioactive Monascus components with anticancer potential, mechanisms of the anticancer effects of Monascus metabolites, and existing problems as well as future perspectives. With the advancement of related fields, the development of novel anticancer Monascus food products and/or pharmaceuticals will be possible with the ultimate goal of decreasing the incidence and mortality of malignancies in humans.
authors.affiliation: aNational Engineering Laboratory for Rice and Byproduct In-depth Processing, Central South University of Forestry and Technology bDepartment of Pathology, College of Medicine, Hunan Normal University, Hunan, China cHerman B Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Indiana University - Purdue University Indianapolis, Indianapolis, Indiana dDepartment of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Junwen
authors.initials: J
authors.lastname: Liu
authors.forename: Feijun
authors.initials: F
authors.lastname: Luo
authors.forename: Qinlu
authors.initials: Q
authors.lastname: Lin
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Rosol
authors.forename: Xiyun
authors.initials: X
authors.lastname: Deng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D001343:Autophagy / Q000187:drug effects; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use*; D002465:Cell Movement / Q000187:drug effects; D005285:Fermentation; D006801:Humans; D032741:Monascus / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D011836:Radiation Tolerance / Q000187:drug effects; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D011838:Radiation-Sensitizing Agents