title: De novo synthesis of multisubstituted aryl amines using alkene cross metathesis.
abstract: The olefin cross-metathesis reaction allows rapid access to 1,5-dicarbonyl intermediates which, upon treatment with a primary or secondary amine, allow the synthesis of a range of multisubstituted carbocyclic aryl amines. This de novo arene synthesis yields nonclassical substitution patterns in a regioselective and predictable approach that is compatible with several functional groups.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford , Mansfield Road, Oxford, OX1 3TA, U.K.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Tatton
authors.forename: Iain
authors.initials: I
authors.lastname: Simpson
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Donohoe
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000588:Amines