title: Investigating the mechanisms of massage efficacy: the role of mechanical immunomodulation.
abstract: Massage has the potential to attenuate the inflammatory process, facilitate early recovery, and provide pain relief from muscular injuries. In this hypothesis-driven paper, we integrate the concept of mechanotransduction with the application of massage to explore beneficial mechanisms. By altering signaling pathways involved with the inflammatory process, massage may decrease secondary injury, nerve sensitization, and collateral sprouting, resulting in increased recovery from damage and reduction or prevention of pain. Our goal is to provide a framework that describes our current understanding of the mechanisms whereby massage therapy activates potentially beneficial immunomodulatory pathways.
authors.affiliation: Department of Rehabilitation Sciences, University of Kentucky, Lexington. Dr Waters-Banker is currently at the Department of Kinesiology, University of Calgary, AB, Canada.
authors.forename: Christine
authors.initials: C
authors.lastname: Waters-Banker
authors.forename: Esther E
authors.initials: EE
authors.lastname: Dupont-Versteegden
authors.forename: Patrick H
authors.initials: PH
authors.lastname: Kitzman
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Butterfield
mesh_terms: D001265:Athletic Injuries / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D056747:Immunomodulation; D008405:Massage; D040542:Mechanotransduction, Cellular; D018482:Muscle, Skeletal / Q000293:injuries* / Q000294:innervation; D009220:Myositis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D009475:Neurons, Afferent / Q000502:physiology; D010146:Pain / Q000517:prevention & control; D059408:Pain Management / Q000379:methods