title: Genetic polymorphism ofCCND1G870A and esophageal cancer susceptibility: A meta-analysis.
abstract: The association between the polymorphism of cyclin D1 (CCND1) and esophageal carcinogenicity has been widely examined, however, it remains controversial. To evaluate the importance ofCCND1G870A polymorphism with regard to the risk of esophageal cancer, a meta-analysis was carried out that reviewed the available literature in order to clarify the controversies. This meta-analysis included 1,154 cases and 1,678 controls forCCND1G870A polymorphism from seven published case-control studies. The odds ratio (OR) and 95% confidence interval (CI) were calculated using the Stata software version 11.1. The results were pooled using a dominant model to appropriately reflect a biological model of the genetic effect. No significant association was observed in the Caucasian (OR=1.64; 95% CI, 0.84-3.20) or the Asian populations (OR=1.30; 95% CI, 0.65-2.62), while no significant association was found in esophageal squamous cell carcinoma (ESCC) (OR=1.74; 95% CI, 0.79-3.81) or esophageal adenocarcinoma (EADC) (OR=1.18; 95% CI, 0.77-1.81). However, the comparison of A vs. G inCCND1G870A showed significant differential susceptibility to esophageal cancer (OR=1.26; 95% CI, 1.00-1.59). These findings suggested that theCCND1G870A polymorphism has no association with esophageal cancer risk in ethnicity and histology, respectively. Further studies are required to assess these associations in greater detail.
authors.affiliation: Department of Cardiothoracic Surgery, Guangxi Medical University, Nanning, Guangxi, P.R. China ;
authors.forename: Wenwu
authors.initials: W
authors.lastname: He
authors.affiliation: Clinical Medicine Major, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, P.R. China ;
authors.forename: Yanbei
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: School of Public Health, Guangxi Medical University, Nanning, Guangxi, P.R. China ;
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Long
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, P.R. China ;
authors.forename: Qiuxi
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Guangxi Research Center, Guangxi Medical University, Nanning, Guangxi, P.R. China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Cardiothoracic Surgery, Guangxi Medical University, Nanning, Guangxi, P.R. China ;
authors.forename: Mingwu
authors.initials: M
authors.lastname: Chen
keywords: G870A; cyclin D1; esophageal cancer; meta-analysis; polymorphism