title: Muscle synergies evoked by microstimulation are preferentially encoded during behavior.
abstract: Electrical microstimulation studies provide some of the most direct evidence for the neural representation of muscle synergies. These synergies, i.e., coordinated activations of groups of muscles, have been proposed as building blocks for the construction of motor behaviors by the nervous system. Intraspinal or intracortical microstimulation (ICMS) has been shown to evoke muscle patterns that can be resolved into a small set of synergies similar to those seen in natural behavior. However, questions remain about the validity of microstimulation as a probe of neural function, particularly given the relatively long trains of supratheshold stimuli used in these studies. Here, we examined whether muscle synergies evoked during ICMS in two rhesus macaques were similarly encoded by nearby motor cortical units during a purely voluntary behavior involving object reach, grasp, and carry movements. At each microstimulation site we identified the synergy most strongly evoked among those extracted from muscle patterns evoked over all microstimulation sites. For each cortical unit recorded at the same microstimulation site, we then identified the synergy most strongly encoded among those extracted from muscle patterns recorded during the voluntary behavior. We found that the synergy most strongly evoked at an ICMS site matched the synergy most strongly encoded by proximal units more often than expected by chance. These results suggest a common neural substrate for microstimulation-evoked motor responses and for the generation of muscle patterns during natural behaviors.
authors.affiliation: Department of Electrical Engineering and Computer Sciences, University of California Berkeley, CA, USA.
authors.forename: Simon A
authors.initials: SA
authors.lastname: Overduin
authors.affiliation: Laboratory of Neuromotor Physiology, Santa Lucia Foundation Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: d'Avella
authors.affiliation: Department of Electrical Engineering and Computer Sciences, University of California Berkeley, CA, USA ; Helen Wills Neuroscience Institute, University of California Berkeley, CA, USA ; UCB-UCSF Joint Graduate Group in Bioengineering, University of California Berkeley, CA, USA.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Carmena
authors.affiliation: Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology Cambridge, MA, USA.
authors.forename: Emilio
authors.initials: E
authors.lastname: Bizzi
keywords: cortex; grasping; hand; macaque; motor; movement; muscle; synergy