title: Urinary bisphenol a levels in girls with idiopathic central precocious puberty.
abstract: OBJECTIVE
  Bisphenol A (BPA) is an industrial chemical, particularly used to harden plastics. BPA is thought to have negative health effects on both laboratory animals and humans. Consider ing the decline in age of onset of puberty noted in recent years, particularly among girls, the importance of BPA as an estrogenic endocrine disruptor has increased. In this study, we aimed to determine urinary BPA levels in girls with idiopathic central precocious puberty (ICPP).
  
  
  METHODS
  Non-obese girls newly diagnosed with ICPP (n=28, age 4-8 years) constituted the study group. The control group consisted of 25 healthy age-matched girls with no history of ICPP or any other endocrine disorder. Urinary BPA levels were measured by using high-performance liquid chromatography.
  
  
  RESULTS
  In the ICPP group, urinary BPA levels were significantly higher compared to the control group [median 8.34 (0.84-67.35) μg/g creatinine and 1.62 (0.3-25.79) μg/g creatinine, respectively (OR=8.68, 95% CI:2.03-32.72, p=0.001)]. There was no marked correlation between urinary BPA levels and body mass index in either group. In the ICPP group, no significant correlations were found between urinary BPA levels and serum luteinizing hormone, follicle-stimulating hormone and estradiol levels.
  
  
  CONCLUSIONS
  To our knowledge, this is the first study evaluating the urinary BPA levels in Turkish girls with ICPP. Our results indicate that the estrogenic effects of BPA may be an etiologic factor in ICPP.
authors.affiliation: Mersin State Hospital, Department of Pediatric Endocrinology, Mersin, Turkey. E-ma-il: drerdemdurmaz@yahoo.com.
authors.forename: Erdem
authors.initials: E
authors.lastname: Durmaz
authors.forename: Ali
authors.initials: A
authors.lastname: Aşçı
authors.forename: Pınar
authors.initials: P
authors.lastname: Erkekoğlu
authors.forename: Sema
authors.initials: S
authors.lastname: Akçurin
authors.forename: Belma Koçer
authors.initials: BK
authors.lastname: Gümüşel
authors.forename: Iffet
authors.initials: I
authors.lastname: Bircan
mesh_terms: D001559:Benzhydryl Compounds / Q000652:urine*; D015415:Biomarkers / Q000652:urine*; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010636:Phenols / Q000652:urine*; D011379:Prognosis; D011629:Puberty, Precocious / Q000652:urine*; D012741:Sexual Maturation; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D015415:Biomarkers; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds