title: [Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats].
abstract: The aim of the present work was an estimation of effects of chronic administration of selective serotonin reuptake inhibitors--fluoxetine (5.0 mg/kg, p.o.) and paroxetine (5.0 mg/kg, p.o.) for 14 days of postnatal period on anxiety-like behavior in the prenatally stressed male rats during pubertal period (1,5 month) and the adult state (3 month). Chronic paroxetine administration to females failed to change an anxiety-like behavior independently from age. On the contrary, administration of fluoxetine resulted in modulating influence on the anxiety-like behavior of prenatally stressed rats dependently from age: anxiolytic effect was noted in young males, while anxiogenic effect was observed in the adult male rats.
authors.forename: N E
authors.initials: NE
authors.lastname: Ordyan
authors.forename: S G
authors.initials: SG
authors.lastname: Pivina
authors.forename: Yu O
authors.initials: YO
authors.lastname: Fedotova
authors.forename: V K
authors.initials: VK
authors.lastname: Akulova
mesh_terms: D000818:Animals; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology / Q000627:therapeutic use*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D017374:Paroxetine / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000188:drug therapy* / Q000209:etiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D012737:Sex Factors; D013315:Stress, Psychological / Q000150:complications
chemical_list: D005473:Fluoxetine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors