title: IL28B rs 12979860 predicts response to treatment in Egyptian hepatitis C virus genotype 4 patients and alpha fetoprotein increases its predictive strength.
abstract: To assess the role of IL28B rs 12979860 polymorphism in predicting response to treatment in genotype 4 (G4) Egyptian patients, and to evaluate the role of alpha fetoprotein (AFP) in increasing the predictive strength of IL28B rs 12979860 polymorphism to predict response to treatment. One hundred thirty 7 HCV patients were genotyped for IL28B rs 12979860 by polymerase chain reaction--restriction fragment length polymorphism technique. The presence of the C allele of IL28B rs 12979860 was associated with response to treatment, while the T allele was associated with failure of response to treatment. AFP is associated with IL28B rs 12979860 SNP genotypes at cut off 2.68 and 4.5 ng/mL individually. Response rate was 1.3 and 1.6, 3 times higher in CC, CT, and TT respectively in patients below AFP 4.5 ng/mL than in patients above it. IL28B rs 12979860 polymorphism is strongly associated with treatment induced response to treatment. AFP (cut off 4.5 mg/mL) increases the predictive power of IL28B in response to treatment.
authors.affiliation: 1 Microbial Biotechnology Department, National Research Center , Cairo, Egypt .
authors.forename: Samar Samir
authors.initials: SS
authors.lastname: Youssef
authors.forename: Eman Abd El-Razek
authors.initials: EA
authors.lastname: Abbas
authors.forename: Asmaa
authors.initials: A
authors.lastname: Mostafa
authors.forename: Moataza Hassan
authors.initials: MH
authors.lastname: Omran
authors.forename: Ahmed
authors.initials: A
authors.lastname: Barakat
authors.forename: Sameh Mohamed
authors.initials: SM
authors.lastname: Seif
mesh_terms: D000328:Adult; D004534:Egypt; D005260:Female; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000235:genetics* / Q000628:therapy; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000378:metabolism*; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D007378:Interleukins; D000509:alpha-Fetoproteins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda