title: Is arterial infiltration still a criterion for unresectability in pancreatic adenocarcinoma?
abstract: As surgical resection remains the only hope for cure in pancreatic cancer (PC), more aggressive surgical approaches have been advocated to increase resection rates. Venous resection demonstrated to be a feasible technique in experienced centers, increasing survival. In contrast, arterial resection is still an issue of debate, continuing to be considered a general contraindication to resection. In the last years there have been significant advances in surgical techniques and postoperative management which have dramatically reduced mortality and morbidity of major pancreatic resections. Furthermore, advances in multimodal neo-adjuvant and adjuvant treatments, as well as the better understanding of tumor biology and new diagnostic options have increased overall survival. In this article we highlight some of the important points that a modern pancreatic surgeon should take into account in the management of PC with arterial involvement in light of the recent advances.
authors.affiliation: Hospital Universitario Madrid Sanchinarro, Centro Integral Oncológico Clara Campal, Facultad de Medicina, Universidad CEU San Pablo, Madrid, España. Electronic address: emilvic@bitmailer.net.
authors.forename: Emilio
authors.initials: E
authors.lastname: Vicente
authors.affiliation: Hospital Universitario Madrid Sanchinarro, Centro Integral Oncológico Clara Campal, Facultad de Medicina, Universidad CEU San Pablo, Madrid, España.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Quijano
authors.affiliation: Hospital Universitario Madrid Sanchinarro, Centro Integral Oncológico Clara Campal, Facultad de Medicina, Universidad CEU San Pablo, Madrid, España.
authors.forename: Benedetto
authors.initials: B
authors.lastname: Ielpo
authors.affiliation: Hospital Universitario Madrid Sanchinarro, Centro Integral Oncológico Clara Campal, Facultad de Medicina, Universidad CEU San Pablo, Madrid, España.
authors.forename: Hipolito
authors.initials: H
authors.lastname: Duran
authors.affiliation: Hospital Universitario Madrid Sanchinarro, Centro Integral Oncológico Clara Campal, Facultad de Medicina, Universidad CEU San Pablo, Madrid, España.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Diaz
authors.affiliation: Hospital Universitario Madrid Sanchinarro, Centro Integral Oncológico Clara Campal, Facultad de Medicina, Universidad CEU San Pablo, Madrid, España.
authors.forename: Isabel
authors.initials: I
authors.lastname: Fabra
authors.affiliation: Hospital Universitario Madrid Sanchinarro, Centro Integral Oncológico Clara Campal, Facultad de Medicina, Universidad CEU San Pablo, Madrid, España.
authors.forename: Catalina
authors.initials: C
authors.lastname: Oliva
authors.affiliation: Hospital Universitario Madrid Sanchinarro, Centro Integral Oncológico Clara Campal, Facultad de Medicina, Universidad CEU San Pablo, Madrid, España.
authors.forename: Sergio
authors.initials: S
authors.lastname: Olivares
authors.affiliation: Hospital Universitario Madrid Sanchinarro, Centro Integral Oncológico Clara Campal, Facultad de Medicina, Universidad CEU San Pablo, Madrid, España.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Caruso
authors.affiliation: Hospital Universitario Madrid Sanchinarro, Centro Integral Oncológico Clara Campal, Facultad de Medicina, Universidad CEU San Pablo, Madrid, España.
authors.forename: Valentina
authors.initials: V
authors.lastname: Ferri
authors.affiliation: Hospital Universitario Madrid Sanchinarro, Centro Integral Oncológico Clara Campal, Facultad de Medicina, Universidad CEU San Pablo, Madrid, España.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ceron
authors.affiliation: Hospital Universitario Madrid Sanchinarro, Centro Integral Oncológico Clara Campal, Facultad de Medicina, Universidad CEU San Pablo, Madrid, España.
authors.forename: Almudena
authors.initials: A
authors.lastname: Moreno
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D001158:Arteries; D002445:Celiac Artery; D006499:Hepatic Artery; D006801:Humans; D017538:Mesenteric Artery, Superior; D009361:Neoplasm Invasiveness; D010180:Pancreatectomy / Q000379:methods; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000601:surgery; D019043:Vascular Neoplasms / Q000473:pathology*
keywords: Cancer de páncreas; Invasión vascular; Major pancreatic resection; Pancreatectomía ampliada; Pancreatic cancer; Vascular invasion