title: Brain derived neurotrophic factor in the retina of the teleost N. furzeri.
abstract: BDNF plays an important role in the development and maintenance of visual circuitries in the retina and brain visual centers. In adulthood, BDNF signaling is involved in neural protection and regeneration of retina. In this survey, we investigated the expression of BDNF in the retina of adult Nothobranchius furzeri, a teleost fish employed for age research. After describing the retina of N. furzeri and confirming that the structure is organized in layers as in all vertebrates, we have studied the localization of BDNF mRNA and protein throughout the retinal layers. BDNF mRNA is detectable in all layers, whereas the protein is lacking in the photoreceptors. The occurrence of BDNF provides new insights on its role in the retina, particularly in view of age-related disease of retina.
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, via Veterinaria, 1, I-80137 Napoli, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Gatta
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, via Veterinaria, 1, I-80137 Napoli, Italy.
authors.forename: Luciana
authors.initials: L
authors.lastname: Castaldo
authors.affiliation: Scuola Normale Superiore of Pisa, Laboratory of Biology, c/o Institute of Biophysics of CNR, via Moruzzi, 1, I-56100 Pisa, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cellerino
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, via Veterinaria, 1, I-80137 Napoli, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: de Girolamo
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, via Veterinaria, 1, I-80137 Napoli, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Lucini
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, via Veterinaria, 1, I-80137 Napoli, Italy. Electronic address: livia.dangelo@unina.it.
authors.forename: Livia
authors.initials: L
authors.lastname: D'Angelo
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor / Q000737:chemistry / Q000378:metabolism*; D003532:Cyprinodontiformes / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology / Q000648:ultrastructure; D012160:Retina / Q000254:growth & development / Q000378:metabolism*; D059506:Telomere Shortening / Q000502:physiology
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor
keywords: BDNF; Retina; Teleost