title: Endomyometriosis ("Uterus-like mass") in an XY Male: Case Report With Molecular Confirmation and Literature Review.
abstract: Male endometriosis and endomyometriosis (also termed "uterus-like mass") are 2 unusual manifestations of endometriosis. We report a case of male endomyometriosis with immunohistochemical and molecular confirmation. A 52-year-old man presented with stabbing pelvic pain. Computed tomography scan showed a mass in the right inguinal area, at the site of prior hernia repair. The lesion was tubular in shape, with a thick muscular wall and a central blood-filled lumen. Microscopically, the tissue showed layers of concentric smooth muscle, with endometrial glands and stroma lining the lumen. Many theories have been proposed regarding the etiology of both endomyometriosis and male endometriosis, including remnant rests of Müllerian tissue and metaplasia. Cases of male endometriosis typically have been linked to estrogen therapy for prostate cancer. Our patient had a history of cirrhosis and took spironolactone, possibly leading to an altered hormonal state that interacted with a reactive/metaplastic process at a site of prior surgery.
authors.affiliation: Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Raul S
authors.initials: RS
authors.lastname: González
authors.affiliation: Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Vnencak-Jones
authors.affiliation: Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Chanjuan
authors.initials: C
authors.lastname: Shi
authors.affiliation: Vanderbilt University School of Medicine, Nashville, TN, USA oluwole.fadare@vanderbilt.edu.
authors.forename: Oluwole
authors.initials: O
authors.lastname: Fadare
mesh_terms: D004717:Endometrium / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
keywords: endomyometriosis; male endometriosis; molecular analysis; uterus-like mass