title: Aortic regurgitation after transcatheter aortic valve replacement.
abstract: Paravalvular aortic regurgitation (AR) negatively affects prognosis following transcatheter aortic valve replacement (TAVR). As transcatheter heart valves (THV) are anchored using a certain degree of oversizing at the level of the aortic annulus, incomplete stent frame expansion because of heavily annular calcifications, suboptimal placement of the prosthesis, and/or annulus-prosthesis size-mismatch can contribute to paravalvular AR with subsequent increased mortality risk. Echocardiography is essential to differentiate between transvalvular and paravalvular AR and to further elucidate the etiology of AR during the procedure. However, because echocardiographic quantification of AR in TAVR patients remains challenging, especially in the implantation situation, a multimodal approach to the evaluation of AR with use of hemodynamic measurements and imaging modalities is useful to precisely quantify the severity of AR immediately after valve deployment. "Next-generation" THVs are already on the market and first results show that paravalvular AR related to design modifications (eg, paravalvular space-fillers, full repositionability) are rarely seen in these valve types.
authors.affiliation: Heart Center Bonn, Department of Medicine II, University Hospital Bonn.
authors.forename: Nikos
authors.initials: N
authors.lastname: Werner
authors.forename: Jan-Malte
authors.initials: JM
authors.lastname: Sinning
mesh_terms: D000818:Animals; D001022:Aortic Valve Insufficiency / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002114:Calcinosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006328:Cardiac Catheterization / Q000009:adverse effects*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects*; D006801:Humans; D011183:Postoperative Complications / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology