title: History of the molecular biology of cytomegaloviruses.
abstract: The history of the molecular biology of cytomegaloviruses from the purification of the virus and the viral DNA to the cloning and expression of the viral genes is reviewed. A key genetic element of cytomegalovirus (the CMV promoter) contributed to our understanding of eukaryotic cell molecular biology and to the development of lifesaving therapeutic proteins. The study of the molecular biology of cytomegaloviruses also contributed to the development of antivirals to control the viral infection.
authors.affiliation: Department of Microbiology, Carver College of Medicine, University of Iowa, 3-701 BSB, 51 Newton Rd., Iowa City, IA, 52242, USA, mark-stinski@uiowa.edu.
authors.forename: Mark F
authors.initials: MF
authors.lastname: Stinski
mesh_terms: D003001:Cloning, Molecular; D003587:Cytomegalovirus / Q000235:genetics* / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000235:genetics / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics*; D015967:Gene Expression Regulation, Viral; D049673:History, 20th Century; D008967:Molecular Biology / Q000266:history / Q000379:methods*; D011401:Promoter Regions, Genetic
chemical_list: D004279:DNA, Viral