title: The role of genetic polymorphisms regulating vitamin D levels in rheumatoid arthritis outcome: a Mendelian randomisation approach.
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Viatte
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
authors.forename: Annie
authors.initials: A
authors.lastname: Yarwood
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
authors.forename: Kate
authors.initials: K
authors.lastname: McAllister
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
authors.forename: Shibeb
authors.initials: S
authors.lastname: Al-Mudhaffer
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK Centre for Biostatistics, Institute of Population Health, The University of Manchester, UK.
authors.forename: Bo
authors.initials: B
authors.lastname: Fu
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
authors.forename: Edward
authors.initials: E
authors.lastname: Flynn
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.
authors.forename: Deborah P M
authors.initials: DP
authors.lastname: Symmons
authors.affiliation: St. Albans City Hospital, St. Albans, UK Health and Human Sciences Research Institute, University of Hertfordshire, UK.
authors.forename: Adam
authors.initials: A
authors.lastname: Young
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Barton
mesh_terms: D000328:Adult; D000368:Aged; D019732:Amide Synthases / Q000235:genetics*; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000235:genetics*; D053493:Cholestanetriol 26-Monooxygenase / Q000235:genetics*; D000072467:Cytochrome P450 Family 2; D005260:Female; D006801:Humans; D008297:Male; D057182:Mendelian Randomization Analysis; D008875:Middle Aged; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011859:Radiography; D012720:Severity of Illness Index; D013250:Steroid Hydroxylases / Q000235:genetics*; D014807:Vitamin D / Q000378:metabolism*; D014809:Vitamin D-Binding Protein / Q000235:genetics*; D065668:Vitamin D3 24-Hydroxylase
chemical_list: D014809:Vitamin D-Binding Protein; D014807:Vitamin D; D013250:Steroid Hydroxylases; D000072467:Cytochrome P450 Family 2; C506833:CYP2R1 protein, human; D053493:Cholestanetriol 26-Monooxygenase; D065668:Vitamin D3 24-Hydroxylase; D044925:Oxidoreductases Acting on CH-CH Group Donors; C019995:7-dehydrocholesterol reductase; D019732:Amide Synthases; C038479:NAD+ synthase
keywords: Arthritis; Gene Polymorphism; Outcomes research; Rheumatoid Arthritis