title: Liver injury possibly related to drug interaction after liver transplant: a case report.
abstract: OBJECTIVE
  Drug-induced hepatotoxicity is potentially lethal. Liver transplant patients receive a large number of medications and adverse drug reactions, and drug-drug interactions must be closely monitored.
  
  
  METHODS
  We report a case of a 29-year-old liver transplant patient who suffered liver injury most likely induced by drug interaction between capecitabine and warfarin. Vitamin K1 caused skin rash possibly because of the distribution and metabolism characteristic of the drug in this patient.
  
  
  CONCLUSIONS
  Close monitoring and prompt discontinuation of the drugs with high volume of distribution and metabolized through the liver are necessary to avoid drug-drug interaction in liver transplant patients.
authors.affiliation: Department of Pharmacy, Tianjin First Central Hospital, Tianjin, China.
authors.forename: L Q
authors.initials: LQ
authors.lastname: Zhu
authors.forename: W T
authors.initials: WT
authors.lastname: Jiang
authors.forename: C
authors.initials: C
authors.lastname: Pan
authors.forename: Y H
authors.initials: YH
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Thian
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000069287:Capecitabine; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology; D004347:Drug Interactions; D016903:Drug Monitoring / Q000379:methods; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D014018:Tissue Distribution; D010837:Vitamin K 1 / Q000009:adverse effects / Q000493:pharmacokinetics; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D014859:Warfarin; D000069287:Capecitabine; D010837:Vitamin K 1; D005472:Fluorouracil
keywords: capecitabine; drug interaction; liver injury; liver transplant; warfarin