title: Diarrhea caused by proton pump inhibitor administration: comparisons among lansoprazole, rabeprazole, and omeprazole.
abstract: BACKGROUND
  The number of patients who require treatment with proton pump inhibitors (PPIs) is increasing in Japan. One of their adverse effects is diarrhea.
  
  
  OBJECTIVE
  We investigated the incidence of diarrhea caused by 3 different PPIs: lansoprazole, rabeprazole, and omeprazole.
  
  
  METHODS
  Patients using PPIs for >1 month were enrolled. Enrolled patients recorded daily stool frequency, stool consistency using the Bristol Stool Scale Form, and impaired quality of life caused by diarrhea for 1 month. Their attending physicians described the types and dosages, and duration of PPI administration, as well as other necessary information.
  
  
  RESULTS
  A total of 255 patients participated. Mean age of the patients was 70.7 years old. During the 1-month observation period, 3.5% of the patients complained of diarrhea. There was no significant difference for the incidence of diarrhea among the 3 types of PPIs. Furthermore, no correlations between diarrhea and length and dosage of PPI administration were found.
  
  
  CONCLUSIONS
  The incidence of diarrhea in patients receiving long-term therapy did not differ among 3 different PPIs. ClinicalTrials.gov identifier: UMIN ID 000005300.
authors.affiliation: Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Shino
authors.initials: S
authors.lastname: Shimura
authors.affiliation: Hamamoto Clinic, Izumo, Shimane, Japan.
authors.forename: Naoharu
authors.initials: N
authors.lastname: Hamamoto
authors.affiliation: Yoshino Clinic, Matsue, Shimane, Japan.
authors.forename: Nagisa
authors.initials: N
authors.lastname: Yoshino
authors.affiliation: Department of Gastroenterology, Matsue Red Cross Hospital, Matsue, Shimane, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kushiyama
authors.affiliation: Department of Gastroenterology, Shimane Prefectural Central Hospital, Izumo, Shimane, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Fujishiro
authors.affiliation: Department of Gastroenterology, Izumo City General Medical Center, Izumo, Shimane, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Komazawa
authors.affiliation: Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Furuta
authors.affiliation: Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Shunji
authors.initials: S
authors.lastname: Ishihara
authors.affiliation: Department of Clinical Nursing, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Adachi
authors.affiliation: Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Shimane, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
keywords: adverse effect; collagenous colitis; diarrhea; loose bowels; proton pump inhibitor