title: Relationship between expression of the sodium/iodide symporter and (131)I uptake in recurrent lesions of differentiated thyroid carcinoma.
abstract: The sodium/iodide symporter (NIS) is known to be responsible for the active accumulation of iodide within the thyroid gland. We evaluated the relationship between the expression of NIS in primary or lymph node lesions and iodine-131 uptake in recurrent lesions of differentiated thyroid cancer. In 67 patients with differentiated thyroid cancer (5 follicular and 62 papillary carcinomas), the expression of NIS was analysed by immunohistochemical staining using polyclonal antibodies against human NIS. We used paraffin block tissues of primary tumours or metastatic lesions, and also assessed (131)I uptake in recurrent lesions of thyroid cancer on postoperative (131)I whole-body scan. Immunohistochemical staining was positive in 22 patients (32.8%), including 2 of 5 follicular and 20 of 62 papillary carcinomas. Recurrence was confirmed in 40 patients pathologically or clinically by serum thyroglobulin, (131)I scan, fluorine-18 fluorodeoxyglucose positron emission tomography and/or computed tomography. Among these 40 patients, 28 showed positive uptake on (131)I scan. Fourteen tumour specimens out of 28 (50%) were positive by NIS immunohistochemical staining. The remaining 12 patients with recurrent cancer showed negative (131)I scans, and all specimens were negative by NIS immunohistochemical staining. Thus, NIS immunohistochemical staining predicted (131)I uptake in recurrent cancer with a 100% positive predictive value and a 46.2% negative predictive value. There was no difference in the positivity of NIS according to the site of recurrence on (131)I scan. Outcome of (131)I therapy could be assessed in 22 of the 28 patients who showed (131)I uptake in recurrent lesions. Patients with positive NIS immunostaining responded to (131)I therapy better than did patients with negative immunostaining (P<0.05). In conclusion, NIS immunohistochemical staining showed a high positive predictive value in predicting iodine uptake. Positive immunohistochemical staining of human NIS in primary or lymph node lesions may predict (131)I accumulation and effectiveness of (131)I therapy in recurrent lesions.
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yungun-dong, Chongno-gu, Seoul 110-744, Korea, Korea.
authors.forename: J J
authors.initials: JJ
authors.lastname: Min
authors.forename: J K
authors.initials: JK
authors.lastname: Chung
authors.forename: Y
authors.initials: Y
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Jeong
authors.forename: D
authors.initials: D
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Jang
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: B
authors.initials: B
authors.lastname: Cho