title: Factors having effect on graft survival in cadaveric renal transplantation.
abstract: BACKGROUND
  One of the problems of cadaveric renal transplantation is that its graft survival rate is less than that for living renal transplantation. We aim to study relationships between the graft survival of cadaveric renal transplantation patients and various factors.
  
  
  METHODS
  We retrospectively analyzed 350 cadaveric renal transplantation patients from our institutions from 1983 to 2011. Kaplan-Meier analysis was performed to evaluate graft survival ratios. Using a multivariable Cox regression model, we evaluated the relationship between graft survival and the factors such as age and gender of donor and recipient, body mass index of recipient, duration of hemodialysis, warm ischemic time, and acute rejection (AR), etc.
  
  
  RESULTS
  Among 235 males and 115 females, the overall mean age was 41 years. Median follow-up was 15 years (2 to 28 years). The graft survival ratio was 97% at 1 year, 85% at 5 years, and 71% at 10 years. Using the Cox regression model, graft survival was affected by donor age (younger than 60 years; hazard ratio [HR] 1.5; 95% confidence interval (CI) 1.0-2.0; P = .027) and early acute rejection (within 3 months; HR 2.1; CI 1.6-2.8; P < .001).
  
  
  CONCLUSIONS
  The graft survival of cadaveric renal transplantation patients is affected by factors of donor age and early AR.
authors.affiliation: Nagoya University Graduate School of Medicine, Aichi, Japan. Electronic address: tfujita@med.nagoya-u.ac.jp.
authors.forename: T
authors.initials: T
authors.lastname: Fujita
authors.affiliation: Nagoya University Graduate School of Medicine, Aichi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.affiliation: Nagoya University Graduate School of Medicine, Aichi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Funahashi
authors.affiliation: Nagoya University Graduate School of Medicine, Aichi, Japan; Chukyo Hospital, Aichi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Komatsu
authors.affiliation: Chukyo Hospital, Aichi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kinukawa
authors.affiliation: Komaki City Hospital, Aichi, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Kamihira
authors.affiliation: Nagoya University Graduate School of Medicine, Aichi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Goto
mesh_terms: D000328:Adult; D002102:Cadaver; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies