title: Serum heat shock protein 47 levels are elevated in acute interstitial pneumonia.
abstract: BACKGROUND
  Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagen. We hypothesized that HSP47 could be a useful marker for fibrotic lung disease. The aim of this study was to evaluate serum levels of HSP47 in patients with various idiopathic interstitial pneumonias (IIPs).
  
  
  METHODS
  Subjects comprised 9 patients with acute interstitial pneumonia (AIP), 12 with cryptogenic organizing pneumonia (COP), 16 with nonspecific interstitial pneumonia (NSIP), 19 with idiopathic pulmonary fibrosis (IPF), and 19 healthy adult volunteers.
  
  
  RESULTS
  Patients with AIP had serum HSP47 levels that were significantly higher than those of COP, NSIP or IPF patients and those of healthy volunteers. In contrast, serum levels of HSP47 among patients with COP, NSIP, IPF, and healthy volunteers did not differ significantly. Receiver operating characteristic curves revealed that the cut-off level for HSP47 that resulted in the highest diagnostic accuracy for discriminating between AIP and COP, NSIP, IPF, and healthy controls was 859.3 pg/mL. The sensitivity, specificity, and diagnostic accuracy were 100.0%, 98.5%, and 98.7%, respectively.
  
  
  CONCLUSIONS
  The present results demonstrate that, among patients with various IIPs, serum levels of HSP47 were elevated specifically in patients with AIP.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, Nagasaki 852-8501, Japan. kakugawa@nagasaki-u.ac.jp.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kakugawa
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Yokota
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ishimatsu
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Shota
authors.initials: S
authors.lastname: Nakashima
authors.forename: Shintaro
authors.initials: S
authors.lastname: Hara
authors.forename: Noriho
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kubota
authors.forename: Mariko
authors.initials: M
authors.lastname: Mine
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nagata
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D050958:HSP47 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D050958:HSP47 Heat-Shock Proteins