title: Osteoarthritis pathogenesis - a complex process that involves the entire joint.
abstract: Osteoarthritis is the most common joint disorder and a major cause of disability with a major socio-economic impact. In these circumstances is very important to understand its pathogenesis. Although previous research focused primarily on changes in the articular cartilage, more recent studies have highlighted the importance of the subchondral bone, synovium, menisci, ligaments, periarticular muscles and nerves. Now osteoarthritis is viewed as a multifactorial disease affecting the whole joint.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Gastroenterology Department, Emergency University Hospital, Bucharest.
authors.forename: G S
authors.initials: GS
authors.lastname: Man
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Department of Rehabilitation Medicine, 3rd Rehabilitation Clinic of National Institute of Rehabilitation, Physical Medicine and Balneology, Bucharest.
authors.forename: G
authors.initials: G
authors.lastname: Mologhianu
mesh_terms: D001842:Bone and Bones / Q000503:physiopathology*; D002358:Cartilage, Articular / Q000503:physiopathology*; D051445:Fibrocartilage / Q000503:physiopathology*; D006801:Humans; D010003:Osteoarthritis / Q000503:physiopathology*; D013583:Synovial Membrane / Q000503:physiopathology*
keywords: cartilage; menisci; osteoarthritis; subchondral bone; synovium