title: Acute kidney injury in lymphoma: a single centre experience.
abstract: Background. Acute kidney injury (AKI) is a common but least studied complication of lymphoma. Objective. To determine the frequency and predictors of AKI in lymphoma and to study the impact of AKI on hospital stay and mortality. Methods. Retrospective review of medical records of hospitalized lymphoma patients aged ≥14 years between January 2008 and December 2011 was done. Results. Out of 365 patients, AKI was present in 31.8% (116/365). Multivariate logistic regression analysis showed that independent predictors for AKI included sepsis (odds ratio (OR) 3.76; 95% CI 1.83-7.72), aminoglycosides (OR 4.75; 95% CI 1.15-19.52), diuretics (OR 2.96; 95% CI 1.31-6.69), tumor lysis syndrome (OR 3.85; 95% CI 1.54-9.59), and R-CVP regimen (OR 4.70; 95% CI 1.20-18.36). AKI stages 2 and 3 was associated with increased hospital stay (OR 2.01; 95% CI 1.19-3.40). Conclusion. AKI was significantly associated with sepsis, aminoglycoside, diuretics, presence of tumor lysis syndrome, and use of R-CVP regimen. Presence of AKIN (Acute Kidney Injury Network) stages 2 and 3 AKI had increased hospital stay. AKI was also associated with increased mortality.
authors.affiliation: Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan.
authors.forename: Muhammad Abdul Mabood
authors.initials: MA
authors.lastname: Khalil
authors.affiliation: Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan.
authors.forename: Hira
authors.identifier: 0000-0002-9200-4265
authors.initials: H
authors.lastname: Latif
authors.affiliation: Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rehman
authors.affiliation: Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan.
authors.forename: Waqar Uddin
authors.initials: WU
authors.lastname: Kashif
authors.affiliation: Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan.
authors.forename: Safia
authors.initials: S
authors.lastname: Awan
authors.affiliation: Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan.
authors.forename: Zarghona
authors.initials: Z
authors.lastname: Khalil
authors.affiliation: Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan.
authors.forename: Uziar
authors.initials: U
authors.lastname: Mushtaq
authors.affiliation: Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan.
authors.forename: Maria
authors.initials: M
authors.lastname: Ahmad
authors.affiliation: Department of Medicine, Khyber Teaching Hospital, Peshawar 25000, Pakistan.
authors.forename: Muhammad Ashhad Ullah
authors.initials: MA
authors.lastname: Khalil
authors.affiliation: Department of Nephrology, SSB Hospital, Kuala Belait KA1131, Brunei Darussalam.
authors.forename: Manickam
authors.initials: M
authors.lastname: Ranga Sami
authors.affiliation: Department of Nephrology, RIPAS Hospital, Bandar Seri Begawan BA1710, Brunei Darussalam.
authors.forename: Jackson
authors.initials: J
authors.lastname: Tan