title: 8-hydroxycudraxanthone G suppresses IL-8 production in SP-C1 tongue cancer cells.
abstract: Production of IL-8 primarily promotes angiogenic responses in cancer cells, which lead to favorable disease progression. Suppressing this production may, therefore, be a significant therapeutic intervention in targeting tumor angiogenesis. This study aimed to evaluate the reduction effects of xanthones in cancer cell lines. Nine known prenylated xanthones (1-9), isolated from the pericarp of Garcinia mangostana Linn (GML), were tested for their ability to suppress IL-8 (interleukin-8) of the SP-C1 (Supri's Clone 1) tongue cancer cell line. Of these compounds, 8-hydroxycudraxanthone-G (4) suppressed IL-8 within 48 hours. This is the first report of 8-hydroxycudraxanthone G suppressing the production of IL-8 (45% at 15.7 microg/mL in 48 hours). These results suggest that the prolonged suppression of IL-8 production by cancer cell lines is concerned in the anti-cancer activity of 8-hydroxycudraxanthone.
authors.forename: Arlette S
authors.initials: AS
authors.lastname: Setiawan
authors.forename: Roosje R
authors.initials: RR
authors.lastname: Oewen
authors.lastname: Supriatno
authors.forename: Willyanti
authors.initials: W
authors.lastname: Soewondo
authors.lastname: Sidik
authors.forename: Unang
authors.initials: U
authors.lastname: Supratman
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D029762:Garcinia mangostana / Q000737:chemistry*; D006801:Humans; D016209:Interleukin-8 / Q000037:antagonists & inhibitors*; D010946:Plants, Medicinal / Q000737:chemistry; D014062:Tongue Neoplasms / Q000188:drug therapy; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: C587829:8-hydroxycudraxanthone G; D000972:Antineoplastic Agents, Phytogenic; D016209:Interleukin-8; D044004:Xanthones