title: Boron-Heck reaction of cyclic enaminones: regioselective direct arylation via oxidative palladium(II) catalysis.
abstract: An oxidative boron-Heck reaction of cyclic enaminones with arylboronic acids is reported. This protocol provides a regioselective arylation at the C6 position of cyclic enaminones. When an N-carbamylated cyclic enaminone was employed, a switch to a conjugate addition reaction occurred in the presence of acid.
authors.affiliation: Department of Chemistry, Department of Medicinal Chemistry, and the Institute for Therapeutic Discovery and Development, University of Minnesota , 717 Delaware Street SE, Minneapolis, Minnesota 55414, United States.
authors.forename: Yong Wook
authors.initials: YW
authors.lastname: Kim
authors.forename: Gunda I
authors.initials: GI
authors.lastname: Georg
mesh_terms: D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D011807:Quinolizines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001897:Boronic Acids; D007659:Ketones; D011728:Pyridones; D011807:Quinolizines; C414385:lasubin I; D010165:Palladium