title: Digestive tolerance and postprandial glycaemic and insulinaemic responses after consumption of dairy desserts containing maltitol and fructo-oligosaccharides in adults.
abstract: OBJECTIVE
  To evaluate the short-term digestive tolerance and glycaemic response of several associations of maltitol and short-chain fructo-oligosaccharides (scFOS) used to replace sugars (for example, dextrose) in foods.
  
  
  METHODS
  Thirty-six healthy subjects aged 18-60 years were recruited for the study and 32 completed it. The subjects consumed six different mixtures of dextrose, maltitol and scFOS added in a chocolate dairy dessert at a dosage of 35 g. The test days were separated by 2-week washout periods. The subjects reported the intensity of four individual gastrointestinal (GI) symptoms, number of bowel movements and stool frequency for the 48 h following consumption of the dessert. A subgroup of 18 subjects also provided blood samples 2 h after intake to evaluate the postprandial glycaemic and insulinaemic responses.
  
  
  RESULTS
  The composite score calculated from the intensity of flatulence, borborygmi, bloating and discomfort was significantly higher (P<0.0001) for all the desserts containing maltitol and/or scFOS than for the control dessert containing dextrose, but remains at the level of mild effects. The number of bowel movements was also slightly increased (P=0.0006) and the stools were softer (P=0.0045) for the first 24 h but not after (P=0.1373 and 0.5420, respectively). Blood glycaemic and insulinaemic responses were lower for all the sugar-free recipes containing maltitol and scFOS in comparison to the control one (P<0.0001).
  
  
  CONCLUSIONS
  This study has shown that maltitol and scFOS can be used jointly when formulating sugar-free foods with the benefit to lower postprandial glycaemic response with only a small and transient increase in non-serious GI symptoms.
authors.affiliation: Innovation Department, Tereos Syral, Marckolsheim, France.
authors.forename: F
authors.initials: F
authors.lastname: Respondek
authors.affiliation: Innovation Department, Tereos Syral, Marckolsheim, France.
authors.forename: C
authors.initials: C
authors.lastname: Hilpipre
authors.affiliation: Biofortis SAS, Saint-Herblain, France.
authors.forename: P
authors.initials: P
authors.lastname: Chauveau
authors.affiliation: Biofortis SAS, Saint-Herblain, France.
authors.forename: M
authors.initials: M
authors.lastname: Cazaubiel
authors.affiliation: Biofortis SAS, Saint-Herblain, France.
authors.forename: D
authors.initials: D
authors.lastname: Gendre
authors.affiliation: Biofortis SAS, Saint-Herblain, France.
authors.forename: C
authors.initials: C
authors.lastname: Maudet
authors.affiliation: Innovation Department, Tereos Syral, Marckolsheim, France.
authors.forename: A
authors.initials: A
authors.lastname: Wagner
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D018592:Cross-Over Studies; D003611:Dairy Products / Q000032:analysis; D003672:Defecation / Q000502:physiology; D004032:Diet; D004063:Digestion / Q000502:physiology*; D004311:Double-Blind Method; D005243:Feces / Q000737:chemistry; D005260:Female; D005414:Flatulence / Q000378:metabolism; D006801:Humans; D008297:Male; D008320:Maltose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008875:Middle Aged; D009844:Oligosaccharides / Q000008:administration & dosage*; D019518:Postprandial Period / Q000502:physiology*; D013402:Sugar Alcohols / Q000008:administration & dosage*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D009844:Oligosaccharides; D013402:Sugar Alcohols; C116580:fructooligosaccharide; D008320:Maltose; C010745:maltitol