title: SerpinB2 mediated regulation of macrophage function during enteric infection.
abstract: Host defense is an orchestrated response involving changes in the expression of receptors and release of mediators from both immune and structural cells. There is a growing recognition of the important role of proteolytic pathways for the protective immune response to enteric pathogens. Enteric nematode infection induces a type 2 immune response with polarization of macrophages toward the alternatively activated phenotype (M2). The Th2 cytokines, IL-4, and IL-13, induce a STAT6-dependent upregulation of the expression of the protease inhibitor, serpinB2, which protects macrophages from apoptosis. M2 are critical to worm clearance and a novel role for serpinB2 is its regulation of the chemokine, CCL2, which is necessary for monocyte and/or macrophage influx into small intestine during infection. There is a growing list of factors including immune (LPS, Th2 cytokines) as well as hormonal (gastrin, 5-HT) that are linked to increased expression of serpinB2. Thus, serpinB2 represents an immune regulated factor that has multiple roles in the intestinal mucosa.
authors.affiliation: Department of Radiation Oncology; University of Maryland School of Medicine; Baltimore, MD USA; Department of Medicine; University of Maryland School of Medicine; Baltimore, MD USA; Department of Physiology; University of Maryland School of Medicine; Baltimore, MD USA.
authors.forename: Terez
authors.initials: T
authors.lastname: Shea-Donohue
authors.affiliation: Department of Radiation Oncology; University of Maryland School of Medicine; Baltimore, MD USA; Department of Medicine; University of Maryland School of Medicine; Baltimore, MD USA.
authors.forename: Aiping
authors.initials: A
authors.lastname: Zhao
authors.affiliation: Department of Physiology; University of Maryland School of Medicine; Baltimore, MD USA; Center for Vascular and Inflammatory Diseases; University of Maryland School of Medicine; Baltimore, MD USA.
authors.forename: Toni M
authors.initials: TM
authors.lastname: Antalis
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000378:metabolism* / Q000469:parasitology*; D006801:Humans; D008264:Macrophages / Q000378:metabolism* / Q000469:parasitology*; D009000:Monocytes / Q000378:metabolism; D009349:Nematode Infections / Q000378:metabolism*; D050800:STAT6 Transcription Factor / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism
chemical_list: D016207:Cytokines; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human
keywords: Th2 cytokines; enteric nematode infection; macrophage; plasminogen activation system; serpinB2