title: Use of a new water-soluble Zn sensor to determine Zn affinity for the amyloid-β peptide and relevant mutants.
abstract: Evaluation of Zn affinity for the amyloid-β peptide involved in Alzheimer's disease and its modified counterparts is reported. This was made possible by the use of a new water-soluble chelator, the properties of which have also been described. Changes in the peptide sequence that impact Zn affinity are briefly discussed.
authors.affiliation: CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse Cedex 4, France.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Noël
authors.forename: Susana
authors.initials: S
authors.lastname: Bustos Rodriguez
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Sayen
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Guillon
authors.forename: Peter
authors.initials: P
authors.lastname: Faller
authors.forename: Christelle
authors.initials: C
authors.lastname: Hureau
mesh_terms: D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D006801:Humans; D010446:Peptide Fragments / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D015032:Zinc / Q000737:chemistry / Q000378:metabolism*
chemical_list: C545487:APP protein, human; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D010446:Peptide Fragments; C433241:amyloid beta-protein (1-16); D015032:Zinc