title: Semen Ziziphi Spinosae and Fructus Gardeniae extracts synergistically improve learning and memory of a mouse model.
abstract: Semen Ziziphi Spinosae (SZS) and Fructus Gardeniae (FG) are two herbs commonly used in traditional Chinese medicine. Previous studies have suggested that Fructus Gardeniae as well as Semen Ziziphi Spinosae are able to regulate the function of the central nervous system. However, their effect on learning and memory has yet to be elucidated. In this study, we examined the effect of SZS and FG on the learning and memory of mice using the methods of step-through and -down passive avoidance tasks and Morris water maze tasks. The results showed that SZS and FG extracts have certain effects on improving the performance of the learning and memory-impaired mouse model. Of note, compound extracts of SZS and FG have a synergistic effect on the learning and memory of mice.
authors.affiliation: Departments of Pharmacology, Medical College of Yan'an University, Yan'an 716000;
authors.forename: Baoli
authors.initials: B
authors.lastname: Li
authors.affiliation: Molecular Biology, Medical College of Yan'an University, Yan'an 716000;
authors.forename: Zhaoying
authors.initials: Z
authors.lastname: Fu
authors.affiliation: Department of Pharmacology, Shanxi University of Traditional Chinese Medicine, Xi'an 712046;
authors.forename: Rui
authors.initials: R
authors.lastname: Hu
authors.affiliation: Department of Physiology, Medical College of Yan'an University, Yan'an 716000, P.R. China.
authors.forename: Yahui
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Departments of Pharmacology, Medical College of Yan'an University, Yan'an 716000;
authors.forename: Zhengxiang
authors.initials: Z
authors.lastname: Zhang
keywords: Fructus Gardeniae; Ziziphi Spinosae; learning and memory