title: Sulfinylimidates as chiral amide equivalents for irreversible, asymmetric aldol reactions.
abstract: A highly selective N-sulfinylimidate aldolization has been developed under mildly basic conditions leading to diastereopure products of high synthetic potential. The innate reversibility of this aldolization was suppressed by the use of titanium as the Lewis acid. An application of this methodology via the synthesis of a potential neurotransmitter reuptake inhibitor is illustrated.
authors.affiliation: Département de Chimie Moléculaire (SERCO) UMR 5250, ICMG FR-2607, CNRS-Université Joseph Fourier , BP 53, 38041 Grenoble Cedex 09, France.
authors.forename: Hannah E
authors.initials: HE
authors.lastname: Bartrum
authors.forename: Audrey
authors.initials: A
authors.lastname: Viceriat
authors.forename: Sébastien
authors.initials: S
authors.lastname: Carret
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Poisson