title: Impact of periodic selective mebendazole treatment on soil-transmitted helminth infections in Cuban schoolchildren.
abstract: OBJECTIVE
  To evaluate the impact of periodic selective treatment with 500 mg mebendazole on soil-transmitted helminth (STH) infections in Cuban schoolchildren.
  
  
  METHODS
  We followed up a cohort of 268 STH-positive schoolchildren, aged 5-14 years at baseline, at six-month intervals for two years and a final follow-up after three years. Kato-Katz stool examination was used to detect infections with Ascaris lumbricoides, Trichuris trichiura and hookworm. Common risk factors related to STHs were assessed by parental questionnaire.
  
  
  RESULTS
  A significant reduction in the number of STH infections was obtained after three years with the highest reduction for T. trichiura (87.8%) and the lowest for hookworm (57.9%). After six months, cure rates (CRs) were 76.9% for A. lumbricoides, 67.4% for T. trichiura and 44.4% for hookworm. After two treatment rounds, more than 75% of all STH-positive children at baseline were cured, but with important differences between STH species (95.2% for A. lumbricoides, 80.5% for T. trichiura and 76.5% for hookworm). At the end of the study, these cumulative CRs were almost 100% for all three STHs. Risk factors for STHs were sex, sanitary disposal and habit of playing in the soil.
  
  
  CONCLUSIONS
  Our results indicate that periodic selective treatment with 500 mg mebendazole is effective in reducing the number of STH infections in Cuban schoolchildren. Although important differences were found between helminth species, two rounds of treatment appeared sufficient to obtain substantial reductions.
authors.affiliation: Department of Health Sciences, VU University Amsterdam, Amsterdam, the Netherlands.|Department of Biomedical Sciences, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium.
authors.forename: Suzanne D
authors.initials: SD
authors.lastname: van der Werff
authors.affiliation: Department of Biomedical Sciences, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium.
authors.forename: Kim
authors.initials: K
authors.lastname: Vereecken
authors.affiliation: Department of Health Sciences, VU University Amsterdam, Amsterdam, the Netherlands.
authors.forename: Kim
authors.initials: K
authors.lastname: van der Laan
authors.affiliation: Department of Health Sciences, VU University Amsterdam, Amsterdam, the Netherlands.
authors.forename: Maiza
authors.initials: M
authors.lastname: Campos Ponce
authors.affiliation: National Institute of Hygiene, Epidemiology and Microbiology, Havana, Cuba.
authors.forename: Raquel
authors.initials: R
authors.lastname: Junco Díaz
authors.affiliation: Pedro Kourí Institute, Havana, Cuba.
authors.forename: Fidel A
authors.initials: FA
authors.lastname: Núñez
authors.affiliation: Pedro Kourí Institute, Havana, Cuba.
authors.forename: Lázara
authors.initials: L
authors.lastname: Rojas Rivero
authors.affiliation: National Institute of Hygiene, Epidemiology and Microbiology, Havana, Cuba.
authors.forename: Mariano
authors.initials: M
authors.lastname: Bonet Gorbea
authors.affiliation: Department of Health Sciences, VU University Amsterdam, Amsterdam, the Netherlands.|Department of Biomedical Sciences, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium.
authors.forename: Katja
authors.initials: K
authors.lastname: Polman
keywords: Cuba; efectividad; effectiveness; efficacité; géohelminthes; helmintos transmitidos por helmintos transmitidos por el suelo; mebendazol; mebendazole; mébendazole; niños escolares; schoolchildren; selective treatment; soil-transmitted helminths; traitement sélectif; tratamiento selectivo; écoliers