title: Congenic strain differences of renal malformations in ACI/Mna rats by introgression of the chromosomal region of BUF/Mna rats containing Pur1.
abstract: The ACI rats developed hereditary renal malformations including agenesis and hydronephrosis at moderate penetrance. During construction of a variety of congenic strains based on ACI/Mna (ACI), BUF/Mna (BUF), and WKY/NCrj (WKY) rats, we found that the renal malformations were significantly suppressed by introgression of a segment of chromosome 13 of BUF rats containing Pur1 locus. It is plausible that this region contain a modifier locus influencing development of renal malformations.
authors.forename: Mutsushi
authors.initials: M
authors.lastname: Matsuyama
authors.forename: Chiemi
authors.initials: C
authors.lastname: Haneda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kato
mesh_terms: D000818:Animals; D020296:Animals, Congenic; D002874:Chromosome Mapping / Q000379:methods*; D002875:Chromosomes / Q000648:ultrastructure*; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D005260:Female; D006869:Hydronephrosis / Q000235:genetics; D007668:Kidney / Q000002:abnormalities*; D007674:Kidney Diseases / Q000235:genetics*; D008297:Male; D051381:Rats; D011912:Rats, Inbred ACI; D011915:Rats, Inbred BUF; D011921:Rats, Inbred WKY; D013045:Species Specificity