title: Cumulative success rates following mild IVF in unselected infertile patients: a 3-year, single-centre cohort study.
abstract: A 3-year, retrospective, single-centre cohort study was conducted in a private infertility centre to determine cumulative live birth rates (LBR) per scheduled oocyte retrieval following minimal ovarian stimulation/natural-cycle IVF in unselected infertile patients. A total of 727 consecutive infertile patients were analysed who underwent 2876 (median 4) cycles with scheduled oocyte retrieval from November 2008 to December 2011. Natural-cycle IVF or clomiphene-based minimal ovarian stimulation was coupled with single-embryo transfer and increased use of delayed vitrified-warmed blastocyst transfer. Main outcome measures were crude and expected age-specific cumulative LBR per scheduled oocyte retrieval. Crude cumulative LBR were 65%, 60%, 39%, 15% and 5% in patients aged 26-34, 35-37, 38-40, 41-42 and 43-44 years, respectively. No live births occurred in patients aged ⩾ 45 years. Dropout rates per cycle were 13-25%. Success rates gradually reached a plateau, with few additional live births after six cycles. Most of the expected success rate was reached within 6 months with almost maximal rates within 15 months of the first oocyte retrieval. Acceptable cumulative LBR are reached with an exclusive minimal ovarian stimulation/single-embryo transfer policy especially in patients aged <38 years but also in intermediate aged patients (38-40 years).
authors.affiliation: Kobe Motomachi Yume Clinic, Kobe, Japan. Electronic address: bodridaniel@gmail.com.
authors.forename: Daniel
authors.initials: D
authors.lastname: Bodri
authors.affiliation: Kobe Motomachi Yume Clinic, Kobe, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawachiya
authors.affiliation: Centre for Reproductive Medicine, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
authors.forename: Michaël
authors.initials: M
authors.lastname: De Brucker
authors.affiliation: Centre for Reproductive Medicine, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
authors.forename: Herman
authors.initials: H
authors.lastname: Tournaye
authors.affiliation: Kobe Motomachi Yume Clinic, Kobe, Japan.
authors.forename: Masae
authors.initials: M
authors.lastname: Kondo
authors.affiliation: Kobe Motomachi Yume Clinic, Kobe, Japan.
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Kato
authors.affiliation: Kobe Motomachi Yume Clinic, Kobe, Japan.
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Matsumoto
mesh_terms: D000328:Adult; D046149:Embryo Culture Techniques; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D008297:Male; D054315:Oocyte Retrieval; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: cumulative live birth; in-vitro fertilization; minimal ovarian stimulation; natural-cycle IVF; poor responder; single-embryo transfer