title: Prognostic value of post-treatment (18)F-FDG PET/CT for advanced head and neck cancer after combined intra-arterial chemotherapy and radiotherapy.
abstract: OBJECTIVE
  To clarify the prognostic value of post-treatment (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in patients with advanced head and neck squamous cell carcinoma (HNSCC) after combined intra-arterial chemotherapy and radiotherapy (IACR).
  
  
  METHODS
  Thirty-six patients with HNSCC who underwent IACR were recruited. The period from the end of IACR to the last post-treatment (18)F-FDG PET/CT examination was 8-12 weeks. Both patient-based and lesion-based analyses were used to evaluate the PET/CT images. For lesion-based analysis, 36 regions (12 lesions of recurrences and 24 scars at primary sites) were selected. The Kaplan-Meier method was used to assess the overall survival (OS) stratified by (18)F-FDG uptake or visual interpretation results.
  
  
  RESULTS
  Twelve patients with recurrence were identified by six months after IACR. The sensitivity and specificity in the patient-based analysis were 67% (8/12) and 88% (21/24), respectively. The mean OS was estimated to be 12.1 months (95% CI, 6.3-18.0 months) for the higher maximum standardized uptake value (SUVmax) group (n=7) and 44.6 months (95% CI, 39.9-49.3 months) for the lower SUVmax group (n=29). OS in the higher SUVmax group (cut-off point, 6.1) or positive visual interpretation group was significantly shorter than that in the lower SUVmax or negative visual interpretation group (P<0.001 and P<0.05, respectively).
  
  
  CONCLUSIONS
  The SUVmax and visual interpretation of HNSCC on post-IACR (18)F-FDG PET/CT can provide prognostic survival estimates.
authors.affiliation: 1 Department of Radiology, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan ; 2 Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan ; 3 Division of nuclear Medicine, International Medical Center of Global Health, Tokyo 162-8655, Japan ; 4 Department of Otolaryngology, Head and Neck Surgery, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
authors.forename: Kimiteru
authors.initials: K
authors.lastname: Ito
authors.affiliation: 1 Department of Radiology, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan ; 2 Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan ; 3 Division of nuclear Medicine, International Medical Center of Global Health, Tokyo 162-8655, Japan ; 4 Department of Otolaryngology, Head and Neck Surgery, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
authors.forename: Keigo
authors.initials: K
authors.lastname: Shimoji
authors.affiliation: 1 Department of Radiology, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan ; 2 Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan ; 3 Division of nuclear Medicine, International Medical Center of Global Health, Tokyo 162-8655, Japan ; 4 Department of Otolaryngology, Head and Neck Surgery, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Miyata
authors.affiliation: 1 Department of Radiology, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan ; 2 Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan ; 3 Division of nuclear Medicine, International Medical Center of Global Health, Tokyo 162-8655, Japan ; 4 Department of Otolaryngology, Head and Neck Surgery, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
authors.forename: Kouhei
authors.initials: K
authors.lastname: Kamiya
authors.affiliation: 1 Department of Radiology, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan ; 2 Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan ; 3 Division of nuclear Medicine, International Medical Center of Global Health, Tokyo 162-8655, Japan ; 4 Department of Otolaryngology, Head and Neck Surgery, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
authors.forename: Ryogo
authors.initials: R
authors.lastname: Minamimoto
authors.affiliation: 1 Department of Radiology, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan ; 2 Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan ; 3 Division of nuclear Medicine, International Medical Center of Global Health, Tokyo 162-8655, Japan ; 4 Department of Otolaryngology, Head and Neck Surgery, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kubota
authors.affiliation: 1 Department of Radiology, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan ; 2 Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan ; 3 Division of nuclear Medicine, International Medical Center of Global Health, Tokyo 162-8655, Japan ; 4 Department of Otolaryngology, Head and Neck Surgery, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
authors.forename: Momoko
authors.initials: M
authors.lastname: Okasaki
authors.affiliation: 1 Department of Radiology, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan ; 2 Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan ; 3 Division of nuclear Medicine, International Medical Center of Global Health, Tokyo 162-8655, Japan ; 4 Department of Otolaryngology, Head and Neck Surgery, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Morooka
authors.affiliation: 1 Department of Radiology, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan ; 2 Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan ; 3 Division of nuclear Medicine, International Medical Center of Global Health, Tokyo 162-8655, Japan ; 4 Department of Otolaryngology, Head and Neck Surgery, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
authors.forename: Jyunkichi
authors.initials: J
authors.lastname: Yokoyama
keywords: 18F-fluorodeoxyglucose (18F-FDG); head and neck cancer; intra-arterial chemotherapy and radiotherapy (IACR); positron emission tomography (PET)/computed tomography (CT); recurrence; survival time