title: Cytotoxic quinones from the roots of Aloe dawei.
abstract: Seven naphthoquinones and nine anthraquinones were isolated from the roots of Aloe dawei by chromatographic separation. The purified metabolites were identified by NMR and MS analyses. Out of the sixteen quinones, 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone is a new compound. Two of the isolates, 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione and 1-hydroxy-8-methoxy-3-methylanthraquinone showed high cytotoxic activity (IC₅₀ 1.15 and 4.85 µM) on MCF-7 breast cancer cells, whereas the others showed moderate to low cytotoxic activity against MDA-MB-231 (ER Negative) and MCF-7 (ER Positive) cancer cells.
authors.affiliation: Department of Chemistry, University of Nairobi, P.O. Box 30197, Nairobi 00100, Kenya. negeraabdisa@yahoo.com.
authors.forename: Negera
authors.initials: N
authors.lastname: Abdissa
authors.affiliation: Department of Chemistry, University of Nairobi, P.O. Box 30197, Nairobi 00100, Kenya. martha_induli@yahoo.com.
authors.forename: Martha
authors.initials: M
authors.lastname: Induli
authors.affiliation: Sahlgrenska Cancer Centre, University of Gothenburg, Gothenburg SE-405 30, Sweden. paul.fitzpatrick@gu.se.
authors.forename: Paul
authors.initials: P
authors.lastname: Fitzpatrick
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden. john.p.alao@cmb.gu.se.
authors.forename: John Patrick
authors.initials: JP
authors.lastname: Alao
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden. Per.Sunnerhagen@cmb.gu.se.
authors.forename: Per
authors.initials: P
authors.lastname: Sunnerhagen
authors.affiliation: Sahlgrenska Cancer Centre, University of Gothenburg, Gothenburg SE-405 30, Sweden. goran.landberg@gu.se.
authors.forename: Göran
authors.initials: G
authors.lastname: Landberg
authors.affiliation: Department of Chemistry, University of Nairobi, P.O. Box 30197, Nairobi 00100, Kenya. ayenesew@uonbi.ac.ke.
authors.forename: Abiy
authors.initials: A
authors.lastname: Yenesew
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden. mate@chem.gu.se.
authors.forename: Máté
authors.initials: M
authors.lastname: Erdélyi
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D011809:Quinones