title: Methamphetamine self-administration attenuates hippocampal serotonergic deficits: role of brain-derived neurotrophic factor.
abstract: Preclinical studies suggest that prior treatment with escalating doses of methamphetamine (METH) attenuates the persistent deficits in hippocampal serotonin (5-hydroxytryptamine; 5HT) transporter (SERT) function resulting from a subsequent 'binge' METH exposure. Previous work also demonstrates that brain-derived neurotrophic factor (BDNF) exposure increases SERT function. The current study investigated changes in hippocampal BDNF protein and SERT function in rats exposed to saline or METH self-administration prior to a binge exposure to METH or saline. Results revealed that METH self-administration increased hippocampal mature BDNF (mBDNF) immunoreactivity compared to saline-treated rats as assessed 24 h after the start of the last session. Further, mBDNF immunoreactivity was increased and SERT function was not altered in rats that self-administered METH prior to the binge METH exposure as assessed 24 h after the binge exposure. These results suggest that prior exposure to contingent METH increases hippocampal mBDNF, and this may contribute to attenuated deficits in SERT function.
authors.affiliation: Department of Pharmacology and Toxicology,University of Utah,Salt Lake City, UT 84112,USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: McFadden
authors.affiliation: Department of Pharmacology and Toxicology,University of Utah,Salt Lake City, UT 84112,USA.
authors.forename: Paula L
authors.initials: PL
authors.lastname: Vieira-Brock
authors.affiliation: Department of Pharmacology and Toxicology,University of Utah,Salt Lake City, UT 84112,USA.
authors.forename: Glen R
authors.initials: GR
authors.lastname: Hanson
authors.affiliation: Department of Pharmacology and Toxicology,University of Utah,Salt Lake City, UT 84112,USA.
authors.forename: Annette E
authors.initials: AE
authors.lastname: Fleckenstein
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage* / Q000494:pharmacology*; D016601:RNA-Binding Proteins / Q000378:metabolism; D011877:Radionuclide Imaging; D051381:Rats; D012646:Self Administration; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D014316:Tritium
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D016601:RNA-Binding Proteins; C482440:Sert1 protein, rat; D014316:Tritium; D012701:Serotonin; D008694:Methamphetamine