title: Temperature-driven switching of the catalytic activity of artificial glutathione peroxidase by the shape transition between the nanotubes and vesicle-like structures.
abstract: Smart supramolecular nanoenzymes with temperature-driven switching property have been successfully constructed by the self-assembly of supra-amphiphiles formed by the cyclodextrin-based host-guest chemistry. The self-assembled nanostructures were catalyst-functionalized and thermosensitively-functionalized through conveniently linking the catalytic center of glutathione peroxidase and thermosensitive polymer to the host cyclodextrin molecules.The ON-OFF switches for the peroxidase activity by reversible transformation of nanostructures from tube to sphere have been achieved through changing the temperature. We anticipate that such intelligent enzyme mimics could be developed to use in an antioxidant medicine with controlled catalytic efficiency according to the needs of the human body in the future.
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University , 2699 Qianjin Road, Changchun 130012, P. R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Huixin
authors.initials: H
authors.lastname: Zou
authors.forename: Zeyuan
authors.initials: Z
authors.lastname: Dong
authors.forename: Lipeng
authors.initials: L
authors.lastname: Zhou
authors.forename: Jiaxi
authors.initials: J
authors.lastname: Li
authors.forename: Quan
authors.initials: Q
authors.lastname: Luo
authors.forename: Junyan
authors.initials: J
authors.lastname: Zhu
authors.forename: Jiayun
authors.initials: J
authors.lastname: Xu
authors.forename: Junqiu
authors.initials: J
authors.lastname: Liu
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000378:metabolism; D055162:Biocatalysis; D003505:Cyclodextrins / Q000737:chemistry / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000737:chemistry / Q000378:metabolism*; D043942:Nanotubes / Q000737:chemistry*; D010316:Particle Size; D044367:Phase Transition; D013499:Surface Properties; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D003505:Cyclodextrins; C052970:poly-N-isopropylacrylamide; D005979:Glutathione Peroxidase