title: Circuits controlling energy balance and mood: inherently intertwined or just complicated intersections?
abstract: Recent reports of adverse psychiatric events from seemingly different types of weight loss therapies highlight a previously underestimated overlap between CNS circuits that control energy balance and those that regulate mood. In this Perspective, we discuss a few potential brain sites where the homeostatic and the hedonic pathways may intersect and suggest that a better understanding of both pathways is necessary for the development of more effective and safer antiobesity therapies.
authors.affiliation: Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.affiliation: Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Syann
authors.initials: S
authors.lastname: Lee
authors.affiliation: Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: joel.elmquist@utsouthwestern.edu.
authors.forename: Joel K
authors.initials: JK
authors.lastname: Elmquist
mesh_terms: D000339:Affect / Q000187:drug effects* / Q000502:physiology; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001067:Appetite Depressants / Q000009:adverse effects* / Q000627:therapeutic use; D001069:Appetite Regulation / Q000502:physiology; D050110:Bariatric Surgery / Q000009:adverse effects / Q000523:psychology; D004038:Diet, Reducing / Q000009:adverse effects / Q000523:psychology; D004435:Eating; D002149:Energy Intake / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D019964:Mood Disorders / Q000139:chemically induced*; D009765:Obesity / Q000378:metabolism / Q000523:psychology*; D015430:Weight Gain / Q000187:drug effects; D061217:Weight Reduction Programs
chemical_list: D014150:Antipsychotic Agents; D001067:Appetite Depressants