title: Synthesis, antioxidant activities of the nickel(II), iron(III) and oxovanadium(IV) complexes with N2O2 chelating thiosemicarbazones.
abstract: The nickel(II), iron(III) and oxovanadium(IV) complexes of the N2O2 chelating thiosemicarbazones were synthesized using 4-hydroxysalicyladehyde-S-methylthiosemicarbazone and R1-substitute-salicylaldehyde (R1: 4-OH, H) in the presence of Ni(II), Fe(III), VO(IV) ions by the template reaction. The structures of the thiosemicarbazone complexes were characterized by FT-IR, (1)H NMR, elemental, ESI-MS and APCI-MS analysis. The synthesized compounds were screened for their antioxidant capacity by using the cupric reducing antioxidant capacity (CUPRAC) method. Trolox equivalent antioxidant capacity (TEAC) of iron(III) complex, 1c, was measured to be higher than that of the other complexes. Other parameters of antioxidant activity (scavenging effects on •OH, O2(•-) and H2O2) of these compounds were also determined. All the compounds have shown encouraging ROS scavenging activities.
authors.affiliation: Department of Chemistry, Inorganic Chemistry Section, Istanbul University, 34320 Avcilar, Istanbul, Turkey. Electronic address: tulaybal@istanbul.edu.tr.
authors.forename: Tülay
authors.initials: T
authors.lastname: Bal-Demirci
authors.affiliation: Department of Chemistry, Inorganic Chemistry Section, Istanbul University, 34320 Avcilar, Istanbul, Turkey.
authors.forename: Musa
authors.initials: M
authors.lastname: Sahin
authors.affiliation: Department of Chemistry, Analytical Chemistry Section, Istanbul University, 34320 Avcilar, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozyürek
authors.affiliation: Department of Chemistry, Analytical Chemistry Section, Istanbul University, 34320 Avcilar, Istanbul, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Kondakçı
authors.affiliation: Department of Chemistry, Inorganic Chemistry Section, Istanbul University, 34320 Avcilar, Istanbul, Turkey.
authors.forename: Bahri
authors.initials: B
authors.lastname: Ulküseven
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D002614:Chelating Agents / Q000737:chemistry / Q000494:pharmacology; D005290:Ferric Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009532:Nickel / Q000737:chemistry* / Q000494:pharmacology; D009609:Nitrous Oxide / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D014638:Vanadates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D002614:Chelating Agents; D005290:Ferric Compounds; D017382:Reactive Oxygen Species; D013882:Thiosemicarbazones; C075743:oxovanadium IV; D014638:Vanadates; D009532:Nickel; D009609:Nitrous Oxide
keywords: Antioxidant; Iron; Nickel; Thiosemicarbazone; Vanadium