title: Treatment of multidrug-resistant and extensively drug-resistant tuberculosis in adolescent patients.
abstract: The authors describe 2 pediatric patients with drug-resistant tuberculosis in whom new diagnostic and therapeutic approaches were crucial to good clinical evolution. Although there was good clinical outcome, important side effects with linezolid and amikacin occurred, namely medullary hypoplasia and neurosensorial hypoacusia, respectively. A multidisciplinary approach with close follow up was of major importance in managing these patients.
authors.affiliation: From the *Department of Paediatrics, Hospital of Santa Maria, Lisbon; † Department of Paediatrics, Hospital Professor Dr. Fernando Fonseca; and ‡Pneumologic Diagnostic Centre, Venda Nova, Amadora, Portugal.
authors.forename: Magda
authors.initials: M
authors.lastname: Rodrigues
authors.forename: Maria
authors.initials: M
authors.lastname: Brito
authors.forename: Miguel
authors.initials: M
authors.lastname: Villar
authors.forename: Paula
authors.initials: P
authors.lastname: Correia
mesh_terms: D000081:Acetamides / Q000627:therapeutic use; D000293:Adolescent; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002648:Child; D054908:Extensively Drug-Resistant Tuberculosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000069349:Linezolid; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D023303:Oxazolidinones / Q000627:therapeutic use; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*
chemical_list: D000081:Acetamides; D000995:Antitubercular Agents; D023303:Oxazolidinones; D000069349:Linezolid