title: Impact of colostrum and plasma immunoglobulin intake on hippocampus structure during early postnatal development in pigs.
abstract: The first milk, colostrum, is an important source of nutrients and an exclusive source of immunoglobulins (Ig), essential for the growth and protection from infection of newborn pigs. Colostrum intake has also been shown to affect the vitality and behaviour of neonatal pigs. The objective of this study was to evaluate the effects of feeding colostrum and plasma immunoglobulin on brain development in neonatal pigs. Positive correlations were found between growth, levels of total protein and IgG in blood plasma and hippocampus development in sow-reared piglets during the first 3 postnatal days. In piglets fed an elemental diet (ED) for 24h, a reduced body weight, a lower plasma protein level and a decreased level of astrocyte specific protein in the hippocampus was observed, as compared to those that were sow-reared. The latter was coincident with a reduced microgliogenesis and an essentially diminished number of neurons in the CA1 area of the hippocampus after 72h. Supplementation of the ED with purified plasma Ig, improved the gliogenesis and supported the trophic and immune status of the hippocampus. The data obtained indicate that the development of the hippocampus structure is improved by colostrum or an Ig-supplemented elemental diet in order to stimulate brain protein synthesis and its development during the early postnatal period.
authors.affiliation: Department of Biology, Lund University, Sölvegatan 35, SE-223 62 Lund, Sweden; Department of Medical Biology, Institute of Rural Medicine, Jaczewskiego 2, 20-950 Lublin, Poland. Electronic address: Stefan.Pierzynowski@telia.com.
authors.forename: Stefan
authors.initials: S
authors.lastname: Pierzynowski
authors.affiliation: Department of Biophysics and Biochemistry, Oles' Honchar Dnepropetrovsk National University, Gagarin Ave. 72, 49050 Dnepropetrovsk, Ukraine. Electronic address: ushakova_g@ukr.net.
authors.forename: Galyna
authors.initials: G
authors.lastname: Ushakova
authors.affiliation: Department of Cytology, Key State Laboratory, Bogomoletz Institute of Physiology, Bogomoletz Street 4, 01024 Kiev, Ukraine.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Kovalenko
authors.affiliation: Department of Cytology, Key State Laboratory, Bogomoletz Institute of Physiology, Bogomoletz Street 4, 01024 Kiev, Ukraine.
authors.forename: Iryna
authors.initials: I
authors.lastname: Osadchenko
authors.affiliation: Department of Cytology, Key State Laboratory, Bogomoletz Institute of Physiology, Bogomoletz Street 4, 01024 Kiev, Ukraine.
authors.forename: Kateryna
authors.initials: K
authors.lastname: Goncharova
authors.affiliation: Department of Biology, Lund University, Sölvegatan 35, SE-223 62 Lund, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Gustavsson
authors.affiliation: Department of Biology, Lund University, Sölvegatan 35, SE-223 62 Lund, Sweden.
authors.forename: Olena
authors.initials: O
authors.lastname: Prykhodko
authors.affiliation: Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition, PAS, Instytucka 3, 05-110 Jablonna, Poland.
authors.forename: Jarek
authors.initials: J
authors.lastname: Wolinski
authors.affiliation: Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition, PAS, Instytucka 3, 05-110 Jablonna, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Slupecka
authors.affiliation: Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition, PAS, Instytucka 3, 05-110 Jablonna, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Ochniewicz
authors.affiliation: Department of Biology, Lund University, Sölvegatan 35, SE-223 62 Lund, Sweden.
authors.forename: Björn
authors.initials: B
authors.lastname: Weström
authors.affiliation: Department of Cytology, Key State Laboratory, Bogomoletz Institute of Physiology, Bogomoletz Street 4, 01024 Kiev, Ukraine.
authors.forename: Galina
authors.initials: G
authors.lastname: Skibo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003126:Colostrum; D019587:Dietary Supplements; D005260:Female; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D007074:Immunoglobulin G / Q000008:administration & dosage* / Q000097:blood*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D013552:Swine / Q000097:blood* / Q000254:growth & development*
chemical_list: D007074:Immunoglobulin G; D009419:Nerve Tissue Proteins
keywords: Brain development; Colostrum; Hippocampus; Immunoglobulin; Neonatal pig