title: Hypoxia-inducible factor-1α as a predictive marker in pre-eclampsia.
abstract: The aim of this study was to determine whether or not the increased levels of hypoxia-inducible factor-1α (HIF-1α) could be used to demonstrate failed placentation in pre-eclamptic mothers. Twenty pregnant females with (pre-eclampsia group) or without pre-eclampsia (control group) were included in the present study. Antenatal and post-delivery HIF-1α transcription factor levels were measured. A significant increase was observed in the HIF-1α levels in the pre- and post-natal pre-eclampsia mothers. The findings suggest that the levels of HIF-1α in the blood of mothers with pre-eclampsia decrease after delivery of the placenta. The results confirm that there is increased HIF-1α in pre-eclampsia and a steady increase in the levels of HIF-1α could be commensurate with the possibility of a patient developing pre-eclampsia at a later trimester.
authors.affiliation: Faculty of Medicine, Newcastle University Medicine Malaysia, Johor, Malaysia.
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Akhilesh
authors.affiliation: International Medical University, Kuala Lumpur, Malaysia.
authors.forename: Vivekananda
authors.initials: V
authors.lastname: Mahalingam
authors.affiliation: International Medical University, Kuala Lumpur, Malaysia.
authors.forename: Sivalingam
authors.initials: S
authors.lastname: Nalliah
authors.affiliation: Hospital Ampang, Kuala Lumpur, Malaysia ;
authors.forename: Rosalina Mohd
authors.initials: RM
authors.lastname: Ali
authors.affiliation: Hospital Ampang, Kuala Lumpur, Malaysia ;
authors.forename: Murali
authors.initials: M
authors.lastname: Ganesalingam
authors.affiliation: Faculty of Medicine, Health and Molecular Sciences, James Cook University, Townsville 4811, Australia.
authors.forename: Nagaraja
authors.initials: N
authors.lastname: Haleagrahara
keywords: hypertension; hypoxia-inducible factor; pre-eclampsia; pregnancy