title: LINE(1)s of evidence in HBV-driven liver cancer.
abstract: Hepatitis B virus (HBV) integration in hepatocellular carcinoma (HCC) is a poorly understood event. In a recent Cancer Cell paper, Lau et al. (2014) describe a HBV-human fusion transcript (HBx-LINE1) that functions as a lncRNA, influences the epithelial-mesenchymal transition, and correlates with reduced patient survival and tumor formation in mice.
authors.affiliation: Institute of Virology, Technische Universität München/Helmholtz Zentrum München, 81675 Munich, Germany. Electronic address: heikenwaelder@helmholtz-muenchen.de.
authors.forename: Mathias
authors.initials: M
authors.lastname: Heikenwalder
authors.affiliation: Institute of Virology, Technische Universität München/Helmholtz Zentrum München, 81675 Munich, Germany. Electronic address: protzer@tum.de.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Protzer
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*; D014760:Viral Fusion Proteins / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D015534:Trans-Activators; D014760:Viral Fusion Proteins