title: Distinct response of lactating and nonlactating rats exposed to inorganic mercury on hepatic δ-aminolevulinic acid dehydratase activity.
abstract: This study investigated if lactating and nonlactating rats presented differences in relation to hepatic sensitivity to HgCl2 and the potential preventive role of ZnCl2. Lactating (days 3-12 of lactation) and nonlactating rats received 27 mg/kg ZnCl2 for five consecutive days and 5 mg/kg HgCl2 for five subsequent days. Lactating and nonlactating rats exposed to HgCl2 presented a decrease in food intake, a decrease in plasma alanine aminotransferase (ALT), and an increase in hepatic Hg levels when compared to the control group. Only lactating rats exposed to HgCl2 presented an increase in hepatic δ-aminolevulinic acid dehydratase activity. On the other hand, only nonlactating rats exposed to HgCl2 presented an increase in plasma aspartate aminotransferase (AST). ZnCl2 pre-exposure partially protected the increase in plasma AST activity presented by nonlactating rats and potentiated the liver Hg accumulation in lactating rats. Pups from the Sal-Hg and Zn-Hg groups showed a decrease in absolute liver weight and an increase in liver Hg levels. Summarizing, this study demonstrated that lactating rats presented distinct biochemical responses compared to nonlactating rats exposed to HgCl2 when hepatic parameters were evaluated.
authors.affiliation: Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
authors.forename: Cláudia S
authors.initials: CS
authors.lastname: Oliveira
authors.forename: Alexandre M
authors.initials: AM
authors.lastname: Favero
authors.forename: Carina
authors.initials: C
authors.lastname: Franciscato
authors.forename: Sônia C A
authors.initials: SC
authors.lastname: da Luz
authors.forename: Maria Ester
authors.initials: ME
authors.lastname: Pereira
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D002712:Chlorides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D007279:Injections, Subcutaneous; D007774:Lactation; D008099:Liver / Q000187:drug effects* / Q000201:enzymology*; D008627:Mercuric Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D000623:Porphobilinogen Synthase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D017967:Zinc Compounds / Q000494:pharmacology
chemical_list: D002712:Chlorides; D017967:Zinc Compounds; D008627:Mercuric Chloride; C016837:zinc chloride; D001219:Aspartate Aminotransferases; D000623:Porphobilinogen Synthase