title: 8-Alkylcoumarins from the fruits of Cnidium monnieri protect against hydrogen peroxide induced oxidative stress damage.
abstract: Three new 8-alkylcoumarins, 7-O-methylphellodenol-B (1), 7-methoxy-8-(3-methyl- 2,3-epoxy-1-oxobutyl)chromen-2-one (2), and 3'-O-methylvaginol (3), together with seven known compounds (4-10) were isolated from the fruits of Cnidium monnieri. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. All the isolates were evaluated the cytoprotective activity by MTS cell proliferation assay and the results showed that all the three new 8-alkylcoumarins exhibited cytoprotective effect on Neuro-2a neuroblastoma cells injured by hydrogen peroxide.
authors.affiliation: Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan. changchii@mail.npust.edu.tw.
authors.forename: Chi-I
authors.initials: CI
authors.lastname: Chang
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei 106, Taiwan. r93223083@ntu.edu.tw.
authors.forename: Wan-Chiao
authors.initials: WC
authors.lastname: Hu
authors.affiliation: Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan. d918214@oz.nthu.edu.tw.
authors.forename: Che-Piao
authors.initials: CP
authors.lastname: Shen
authors.affiliation: Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan. bdhsu@life.nthu.edu.tw.
authors.forename: Ban-Dar
authors.initials: BD
authors.lastname: Hsu
authors.affiliation: Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan. linwy@mail.cmu.edu.tw.
authors.forename: Wei-Yong
authors.initials: WY
authors.lastname: Lin
authors.affiliation: Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. whw@mail.nsysu.edu.tw.
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. whw@mail.nsysu.edu.tw.
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.affiliation: Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan. jbwu@mail.cmu.edu.tw.
authors.forename: Jin-Bin
authors.initials: JB
authors.lastname: Wu
authors.affiliation: Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan. kuoyh@mail.cmu.edu.tw.
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000818:Animals; D019661:Apiaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009447:Neuroblastoma / Q000473:pathology; D016877:Oxidants / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects*; D020011:Protective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D003374:Coumarins; D016877:Oxidants; D020011:Protective Agents; C030123:coumarin; D006861:Hydrogen Peroxide