title: No relation between ACE-I/D polymorphism and high altitude pulmonary edema in the Han Chinese.
abstract: OBJECTIVE
  To explore whether the angiotensin I -converting enzyme (ACE) I/D (insertion/ deletion) polymorphism is associated with the susceptibility to high altitude pulmonary edema (HAPE) in the Han Chinese.
  
  
  METHODS
  One hundred and forty-seven HAPE-p (HAPE patients) and 193 HAPE-r (HAPE resistants) were enrolled from the Yushu earthquake reconstruction workers in Qinghai province where the altitude is over 3 500 m above sea level. Blood samples were collected from each of the HAPE-p and HAPE-r groups. Information about physiological phenotypes was obtained via fieldwork investigation. The ACE-I/D polymorphism in HAPE-p and HAPE-r was detected by polymerase chain reaction (PCR).
  
  
  RESULTS
  The SaO2 was significantly lower while HR was significantly higher in HAPE-p group than those in HAPE-r group. The genotype frequencies of ACE-I/D for II, ID, DD in HAPE-r and HAPE-p groups were 0.430, 0.446, 0.124 and 0.435, 0.469, 0.095, respectively, the allelic frequencies of I and D were 0.650, 0.350 and 0.670, 0.330, respectively. The OR of ID, DD and D alleles relative to II for HAPE was 0.961 (0.610-1.514), 1.322 (0.634-2.758) and 1.080 (0.783-1.489). There was no significant difference of the genotypic and the allelic frequencies in ACE-I/D polymorphism between HAPE-p and HAPE-r groups.
  
  
  CONCLUSIONS
  There is no relation between ACE-I/D polymorphism and HAPE in the Han Chinese.
authors.forename: Ying-Zhong
authors.initials: YZ
authors.lastname: Yang
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Guan
authors.forename: Yang
authors.initials: Y
authors.lastname: Du
authors.forename: Qin
authors.initials: Q
authors.lastname: Ga
authors.forename: Ri-Li
authors.initials: RL
authors.lastname: Ge
mesh_terms: D000483:Alleles; D000531:Altitude; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011654:Pulmonary Edema / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A