title: A preliminary X-ray study of murine Tnfaip8/Oxi-α.
abstract: Tnfaip8/oxidative stress regulated gene-α (Oxi-α) is a novel protein expressed specifically in brain dopaminergic neurons and its over-expression has been reported to protect dopaminergic cells against OS-induced cell death. In this study, murine C165S mutant Tnfaip8/Oxi-α has been crystallized and X-ray data have been collected to 1.8 Å using synchrotron radiation. The crystal belonged to the primitive orthorhombic space group P21212, with unit-cell parameters a = 66.9, b = 72.3, c = 93.5 Å. A full structural determination is under way in order to provide insights into the structure-function relationships of this protein.
authors.affiliation: College of Pharmacy and Graduate School of Pharmaceutical Sciences, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea. yidaeun89@gmail.com.
authors.forename: Daeun
authors.initials: D
authors.lastname: Lee
authors.affiliation: College of Pharmacy and Graduate School of Pharmaceutical Sciences, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea. shfwk31@gmail.com.
authors.forename: Mi-Sun
authors.initials: MS
authors.lastname: Kim
authors.affiliation: College of Pharmacy and Graduate School of Pharmaceutical Sciences, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea. whitedakd@gmail.com.
authors.forename: Jimin
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Chemistry and Nano Science, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea. gjjhon@ewha.ac.kr.
authors.forename: Gil-Ja
authors.initials: GJ
authors.lastname: Jhon
authors.affiliation: College of Pharmacy and Graduate School of Pharmaceutical Sciences, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea. hjson@ewha.ac.kr.
authors.forename: Jin H
authors.initials: JH
authors.lastname: Son
authors.affiliation: College of Pharmacy and Graduate School of Pharmaceutical Sciences, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea. dhshin55@ewha.ac.kr.
authors.forename: Dong Hae
authors.initials: DH
authors.lastname: Shin
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D003460:Crystallization; D018360:Crystallography, X-Ray; D004591:Electrophoresis, Polyacrylamide Gel; D051379:Mice; D050505:Mutant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D020125:Mutation, Missense; D017356:Synchrotrons
chemical_list: D051017:Apoptosis Regulatory Proteins; D050505:Mutant Proteins; C550729:TNFAIP8 protein, mouse