title: HIV cure research: advances and prospects.
abstract: Thirty years after the identification of HIV, a cure for HIV infection is still to be achieved. Advances of combined antiretroviral therapy (cART) in recent years have transformed HIV infection into a chronic disease when treatment is available. However, in spite of the favorable outcomes provided by the newer therapies, cART is not curative and patients are at risk of developing HIV-associated disorders. Moreover, universal access to antiretroviral treatment is restricted by financial obstacles. This review discusses the most recent strategies that have been developed in the search for an HIV cure and to improve life quality of people living with HIV.
authors.affiliation: Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris Cedex 15, France; CEA, Division of Immuno-Virology, iMETI/DSV, 18 Route du Panorama, 92265 Fontenay-aux-Roses, France. Electronic address: caroline.pereira-bittencourt@pasteur.fr.
authors.forename: Caroline P
authors.initials: CP
authors.lastname: Passaes
authors.affiliation: Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris Cedex 15, France. Electronic address: asier.saez-cirion@pasteur.fr.
authors.forename: Asier
authors.initials: A
authors.lastname: Sáez-Cirión
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D035843:Biomedical Research / Q000639:trends; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans
chemical_list: D044966:Anti-Retroviral Agents
keywords: Control of infection; Eradication; HIV cure; HIV reservoirs; Reactivation of latent virus; Remission of HIV infection; Repression of provirus