title: Expression of CD11b as an adhesion molecule on neutrophils in children with Kawasaki disease.
abstract: Inflammation of blood vessels is a characteristic feature of Kawasaki disease. Neutrophils play a key role in the inflammatory responses where movement of neutrophils toward the site of inflammation depends on CD11b/CD18 expression as adhesion molecules on these cells. The purpose of this study was to investigate CD11b/CD18 expression in patients with Kawasaki disease upon diagnosis and after treatment.The study included 20 children with Kawasaki disease aged from 3 months to 8 years. Mean fluorescence intensity of CD11b levels on diagnosis and at 1-2 and 6 weeks after intravenous immunoglobulin (IVIG) therapy was measured in these patients. Level of CD11b was measured in age-matched healthy children and febrile children (each 21) as negative and positive controls, respectively.Mean fluorescence intensity of CD11b in Kawasaki patients was lower than that of the control groups before and after 1-2 weeks of IVIG therapy. There were no significant differences in CD11b in Kawasaki patients either with aneurysm or without aneurysm. The CD11b levels at the diagnosis time and after treatment with IVIG in our patients with Kawasaki were lower than the control groups.
authors.affiliation: Department of Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran. shahidiman@yahoo.com.
authors.forename: Behzad
authors.initials: B
authors.lastname: Heidari
authors.affiliation: Department of Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran and Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Aminr@sums.ac.ir.
authors.forename: Reza
authors.initials: R
authors.lastname: Amin
authors.affiliation: Department of Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran and Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. kashefs@sums.ac.ir.
authors.forename: Sara
authors.initials: S
authors.lastname: Kashef
authors.affiliation: Department of Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran and Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Alyasins@sums.ac.ir.
authors.forename: Soheila
authors.initials: S
authors.lastname: Alyasin
authors.affiliation: Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. moghtadery@sums.ac.ir.
authors.forename: Mozhgan
authors.initials: M
authors.lastname: Moghtaderi
authors.affiliation: Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Aminshahidim2008@yahoo.com.
authors.forename: Maneli
authors.initials: M
authors.lastname: Aminshahidi
authors.affiliation: Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Kalanim@sums.ac.ir.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Kalani
mesh_terms: D039481:CD11b Antigen / Q000032:analysis*; D018821:CD18 Antigens / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000188:drug therapy / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*
chemical_list: D039481:CD11b Antigen; D018821:CD18 Antigens; C509295:ITGAM protein, human; D016756:Immunoglobulins, Intravenous