title: Lack of Association between PTPN22 Gene +1858 C>T Polymorphism and Susceptibility to Generalized Vitiligo in a Turkish Population.
abstract: BACKGROUND
  Vitiligo is an autoimmune polygenic disorder characterized by loss of pigmentation due to melanocyte destruction. The PTPN22 gene +1858 C>T single nucleotide polymorphism (rs2476601) has been shown to be associated with various autoimmune disorders.
  
  
  OBJECTIVE
  The aim of this study was to investigate whether the PTPN22 gene +1858 C>T single nucleotide polymorphism is associated with susceptibility to generalized vitiligo in a Turkish population.
  
  
  METHODS
  One hundred and seven patients with generalized vitiligo, and one hundred and twelve gender-, age-, and ethnic-matched controls were enrolled in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  The PTPN22 +1858 C>T genotype and allele frequencies of the generalized vitiligo patients did not differ significantly from those of healthy controls.
  
  
  CONCLUSIONS
  We found no association between the PTPN22 +1858 C>T gene polymorphism and vitiligo susceptibility in Turkish generalized-vitiligo patients.
authors.affiliation: Department of Medical Biology, Medical Faculty, University of Harran, Sanliurfa, Turkey.
authors.forename: Halit
authors.initials: H
authors.lastname: Akbas
authors.affiliation: Department of Dermatology, Medical Faculty, University of Firat, Elazıg, Turkey.
authors.forename: Selma Bakar
authors.initials: SB
authors.lastname: Dertlioglu
authors.affiliation: Department of Medical Biology, Medical Faculty, University of Harran, Sanliurfa, Turkey.
authors.forename: Fuat
authors.initials: F
authors.lastname: Dilmec
authors.affiliation: Department of Internal Medicine, Bagcilar Education and Research, İstanbul, Turkey.
authors.forename: Ahmet Engin
authors.initials: AE
authors.lastname: Atay
keywords: PTPN22 gene; Polymerase chain reaction-restriction fragment length polymorphism; Vitiligo