title: Correlation between CT-based measured renal volumes and nuclear-renography-based split renal function in living kidney donors. Clinical diagnostic utility and practice patterns.
abstract: BACKGROUND
  Living donor evaluation involves imaging to determine the choice of kidney for nephrectomy. Our aim was to study the diagnostic accuracy and correlation between CT-based volume measurements and split renal function (SRF) as measured by nuclear renography in potential living donors and its impact on kidney selection decision.
  
  
  METHODS
  We analyzed 190 CT-based volume measurements in healthy donors, of which 65 donors had a radionuclide study performed to determine SRF.
  
  
  RESULTS
  There were no differences in demographics, anthropometric measurements, total volumes, eGFR, creatinine clearances between those who required a nuclear scan and those who did not. There was a significant correlation between CT-volume-measurement-based SRF and nuclear-scan-based SRF (Pearson coefficient r 0.59; p < 0.001). Furthermore, selective nuclear-based SRF allowed careful selection of donor nephrectomy, leaving the donor with the higher functioning kidney in most cases. There was also a significantly higher number of right-sided nephrectomies selected after nuclear-based SRF studies.
  
  
  CONCLUSIONS
  CT-based volume measurements in living donor imaging have sufficient correlation with nuclear-based SRF. Selective use of nuclear-scan-based SRF allows careful selection for donor nephrectomy.
authors.affiliation: Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Diez
authors.forename: John
authors.initials: J
authors.lastname: Powelson
authors.forename: Chandru P
authors.initials: CP
authors.lastname: Sundaram
authors.forename: Tim E
authors.initials: TE
authors.lastname: Taber
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Mujtaba
authors.forename: Muhammad S
authors.initials: MS
authors.lastname: Yaqub
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Mishler
authors.forename: William C
authors.initials: WC
authors.lastname: Goggins
authors.forename: Asif A
authors.initials: AA
authors.lastname: Sharfuddin
mesh_terms: D000328:Adult; D046148:Donor Selection; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D007677:Kidney Function Tests / Q000379:methods*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D009392:Nephrectomy; D010818:Practice Patterns, Physicians'; D011379:Prognosis; D011866:Radioisotope Renography / Q000379:methods; D012189:Retrospective Studies; D020858:Tissue and Organ Harvesting; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: CT; kidney transplantation; kidney volume; living donor; nuclear renography; split renal function