title: KIBRA: In the brain and beyond.
abstract: In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.
authors.affiliation: Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: Shuping
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Molecular Nephrology, University Hospital Mϋnster, Germany.
authors.forename: Dirk Oliver
authors.initials: DO
authors.lastname: Wennmann
authors.affiliation: Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Molecular Nephrology, University Hospital Mϋnster, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Kremerskothen
authors.affiliation: Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: dongj@unmc.edu.
authors.forename: Jixin
authors.initials: J
authors.lastname: Dong
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism*; D063646:Carcinogenesis / Q000235:genetics*; D002465:Cell Movement / Q000235:genetics; D016764:Cell Polarity / Q000235:genetics; D003071:Cognition / Q000502:physiology; D004330:Drosophila; D000090683:Hippo Signaling Pathway; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008568:Memory / Q000502:physiology; D051379:Mice; D008938:Mitosis / Q000235:genetics; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000235:genetics* / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D021381:Protein Transport / Q000235:genetics
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D010750:Phosphoproteins; C513637:WWC1 protein, human; D017346:Protein Serine-Threonine Kinases
keywords: Cell migration; Cell polarity; Hippo pathway; KIBRA; Memory performance; Phosphorylation