title: Ultracompact three-dimensional tubular conductivity microsensors for ionic and biosensing applications.
abstract: We present ultracompact three-dimensional tubular structures integrating Au-based electrodes as impedimetric microsensors for the in-flow determination of mono- and divalent ionic species and HeLa cells. The microsensors show an improved performance of 2 orders of magnitude (limit of detection = 0.1 nM for KCl) compared to conventional planar conductivity detection systems integrated in microfluidic platforms and the capability to detect single HeLa cells in flowing phosphate buffered saline. These highly integrated conductivity tubular sensors thus open new possibilities for lab-in-a-tube devices for bioapplications such as biosensing and bioelectronics.
authors.affiliation: Institute for Integrative Nanosciences, IFW Dresden , Helmholtzstrasse 20, 01069 Dresden, Germany.
authors.forename: Cynthia S
authors.initials: CS
authors.lastname: Martinez-Cisneros
authors.forename: Samuel
authors.initials: S
authors.lastname: Sanchez
authors.forename: Wang
authors.initials: W
authors.lastname: Xi
authors.forename: Oliver G
authors.initials: OG
authors.lastname: Schmidt
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D017097:Electric Impedance; D055664:Electrochemical Techniques / Q000295:instrumentation; D004566:Electrodes; D004867:Equipment Design; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007477:Ions / Q000032:analysis*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D059010:Single-Cell Analysis / Q000295:instrumentation*
chemical_list: D007477:Ions; D006046:Gold