title: Variants associated with susceptibility to pancreatic cancer and melanoma do not reciprocally affect risk.
abstract: BACKGROUND
  Melanoma cases may exist in pancreatic cancer kindreds, whereas there is increased risk of pancreatic cancer in familial melanoma. The two cancers may share genetic susceptibility variants in common.
  
  
  METHODS
  Three dbGaP (datasets in Genotypes and Phenotypes)-deposited GWAS (genome-wide association study) datasets (MD Anderson melanoma, PanScan 1, and PanScan 2 for pancreatic cancer) were used. Thirty-seven melanoma susceptibility variants in 22 genomic regions from published GWAS, plus melanoma-related genes and pathways were examined for pancreatic cancer risk in the PanScan datasets. Conversely, nine known pancreatic cancer susceptibility variants were examined for melanoma risk in the MD Anderson dataset.
  
  
  RESULTS
  In the PanScan data, initial associations were found with melanoma susceptibility variants in NCOA6 [rs4911442; OR, 1.32; 95% confidence interval (CI), 1.03-1.70; P = 0.03], YWHAZP5 (rs17119461; OR, 2.62; 95% CI, 1.08-6.35; P = 0.03), and YWHAZP5 (rs17119490; OR, 2.62; 95% CI, 1.08-6.34; P = 0.03), TYRP1 (P = 0.04), and IFNA13 (P = 0.04). In the melanoma dataset, two pancreatic cancer susceptibility variants were associated: NR5A2 (rs12029406; OR, 1.39; 95% CI, 1.01-1.92; P = 0.04) and CLPTM1L-TERT (rs401681; OR, 1.16; 95% CI, 1.01-1.34; P = 0.04). None of these associations remained significant after correcting for multiple comparisons.
  
  
  CONCLUSIONS
  Reported variants of melanoma genes and pathways do not play a role in pancreatic cancer predisposition. Reciprocally, pancreatic cancer susceptibility variants are not associated with melanoma risk.
  
  
  CONCLUSIONS
  Known melanoma-related genes and pathways, as well as GWAS-derived susceptibility variants of melanoma and pancreatic cancer, do not explain the shared genetic etiology of these two cancers. Cancer Epidemiol Biomarkers Prev; 23(6); 1121-4. ©2014 AACR.
authors.affiliation: Authors' Affiliations: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Departments of Obstetrics and Gynecology and Environmental Medicine, New York University School of Medicine, New York, New York; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Lang
authors.initials: L
authors.lastname: Wu
authors.affiliation: Authors' Affiliations: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Departments of Obstetrics and Gynecology and Environmental Medicine, New York University School of Medicine, New York, New York; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Alisa M
authors.initials: AM
authors.lastname: Goldstein
authors.affiliation: Authors' Affiliations: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Departments of Obstetrics and Gynecology and Environmental Medicine, New York University School of Medicine, New York, New York; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.affiliation: Authors' Affiliations: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Departments of Obstetrics and Gynecology and Environmental Medicine, New York University School of Medicine, New York, New York; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Xiaohong Rose
authors.initials: XR
authors.lastname: Yang
authors.affiliation: Authors' Affiliations: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Departments of Obstetrics and Gynecology and Environmental Medicine, New York University School of Medicine, New York, New York; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Kari G
authors.initials: KG
authors.lastname: Rabe
authors.affiliation: Authors' Affiliations: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Departments of Obstetrics and Gynecology and Environmental Medicine, New York University School of Medicine, New York, New York; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Alan A
authors.initials: AA
authors.lastname: Arslan
authors.affiliation: Authors' Affiliations: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Departments of Obstetrics and Gynecology and Environmental Medicine, New York University School of Medicine, New York, New York; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Federico
authors.initials: F
authors.lastname: Canzian
authors.affiliation: Authors' Affiliations: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Departments of Obstetrics and Gynecology and Environmental Medicine, New York University School of Medicine, New York, New York; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Wolpin
authors.affiliation: Authors' Affiliations: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Departments of Obstetrics and Gynecology and Environmental Medicine, New York University School of Medicine, New York, New York; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Rachael
authors.initials: R
authors.lastname: Stolzenberg-Solomon
authors.affiliation: Authors' Affiliations: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Departments of Obstetrics and Gynecology and Environmental Medicine, New York University School of Medicine, New York, New York; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Laufey T
authors.initials: LT
authors.lastname: Amundadottir
authors.affiliation: Authors' Affiliations: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Departments of Obstetrics and Gynecology and Environmental Medicine, New York University School of Medicine, New York, New York; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany Petersen.Gloria@mayo.edu.
authors.forename: Gloria M
authors.initials: GM
authors.lastname: Petersen
mesh_terms: D004198:Disease Susceptibility; D005260:Female; D014644:Genetic Variation; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D012878:Skin Neoplasms; D000096142:Cutaneous Malignant Melanoma