title: Human cathelicidin LL-37 resistance and increased daptomycin MIC in methicillin-resistant Staphylococcus aureus strain USA600 (ST45) are associated with increased mortality in a hospital setting.
abstract: Bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) USA600 has been associated with increased patient mortality. We found that USA600 MRSA exhibited significantly increased resistance to human cathelicidin LL-37 killing and daptomycin MIC creep compared to non-USA600 MRSA. Virulent health care-associated MRSA strains may coevolve innate host defense peptide and antibiotic resistances.
authors.affiliation: University of California San Diego School of Medicine, La Jolla, California, USA gsakoulas@ucsd.edu.
authors.forename: George
authors.initials: G
authors.lastname: Sakoulas
authors.affiliation: University of California San Diego School of Medicine, La Jolla, California, USA.
authors.forename: Kripa
authors.initials: K
authors.lastname: Guram
authors.affiliation: Henry Ford Hospital, Wayne State University School of Medicine, Detroit, Michigan, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Reyes
authors.affiliation: University of California San Diego School of Medicine, La Jolla, California, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Nizet
authors.affiliation: Henry Ford Hospital, Wayne State University School of Medicine, Detroit, Michigan, USA.
authors.forename: Marcus
authors.initials: M
authors.lastname: Zervos
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology / Q000401:mortality; D003428:Cross Infection / Q000382:microbiology / Q000401:mortality*; D017576:Daptomycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006761:Hospitals; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D013203:Staphylococcal Infections / Q000382:microbiology / Q000401:mortality*; D014481:United States; D054804:Cathelicidins
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D017576:Daptomycin; D054804:Cathelicidins