title: The mean platelet volume levels in children with PFAPA syndrome.
abstract: OBJECTIVE
  To assess whether mean platelet volume (MPV) can be used as a marker in the differential diagnosis of periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome.
  
  
  METHODS
  The leucocyte counts, thrombocyte counts, and MPV values of 57 children with PFAPA syndrome were recorded during an attack and an attack free period. These values were compared with a healthy control group of 55 individuals. Demographic features of the PFAPA patients group including age, gender and age of first attack, age at diagnosis, frequency of attacks, serum reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were also recorded.
  
  
  RESULTS
  The MPV values of the children with PFAPA both during an attack and attack free period were found significantly lower than the MPV values of healthy control group (p<0.001). Also, the MPV values of the children with PFAPA during an attack were significantly lower than in attack free periods (p<0.001). The MPV values showed no correlation with leucocytes counts, CRP, and ESR during attacks. A 8.30fl [area under the curve (AUC: 0.965)] optimal cutoff value of MPV with a sensitivity of 89.5% and specificity of 92.8% was determined during an attack in children with PFAPA.
  
  
  CONCLUSIONS
  The MPV values during an attack and attack free period of patients with PFAPA is lower than in controls. The MPV values may be used as a marker in the differential diagnosis of PFAPA syndrome but more studies are needed and they should be prospective in order to validate this data.
authors.affiliation: Adiyaman University, School of Medicine, Department of Pediatrics, Adiyaman, Turkey. Electronic address: drmehmettekin@hotmail.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tekin
authors.affiliation: Inonu University, Medical Faculty, Department of Otorhinolaryngology, Malatya, Turkey.
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Toplu
authors.affiliation: Adiyaman University, School of Medicine, Department of Pediatrics, Adiyaman, Turkey; Adiyaman University, School of Medicine, Department of Pediatrics, Neonatology Clinic, Adiyaman, Turkey.
authors.forename: Zelal
authors.initials: Z
authors.lastname: Kahramaner
authors.affiliation: Adiyaman University, School of Medicine, Department of Pediatrics, Adiyaman, Turkey; Adiyaman University, School of Medicine, Department of Pediatrics, Neonatology Clinic, Adiyaman, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Erdemir
authors.affiliation: Sevgi Hospital, Department of Pediatrics, Malatya, Turkey.
authors.forename: Abdulgani
authors.initials: A
authors.lastname: Gulyuz
authors.affiliation: Adiyaman University, School of Medicine, Department of Pediatrics, Adiyaman, Turkey.
authors.forename: Capan
authors.initials: C
authors.lastname: Konca
authors.affiliation: Adiyaman University, School of Medicine, Department of Statistics, Adiyaman, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Uckardes
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005334:Fever / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007958:Leukocyte Count; D008199:Lymphadenitis / Q000097:blood / Q000175:diagnosis*; D008297:Male; D063847:Mean Platelet Volume; D010612:Pharyngitis / Q000097:blood / Q000175:diagnosis*; D010976:Platelet Count; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013281:Stomatitis, Aphthous / Q000097:blood* / Q000175:diagnosis*; D013577:Syndrome
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: Erythrocyte sedimentation rate; Leucocytosis; Mean platelet volume; PFAPA syndrome; Serum reactive protein