title: Prominent hypereosinophilia with disseminated intravascular coagulation as an unusual presentation of advanced gastric cancer.
abstract: A 78-year-old woman was admitted to our hospital complaining of anorexia and purpura of the extremities. She presented with prominent peripheral eosinophilia and disseminated intravascular coagulation (DIC). Despite receiving intensive therapy for DIC, her illness worsened. Esophagogastroduodenoscopy revealed advanced gastric cancer (AGC), and a bone marrow biopsy led to a diagnosis of disseminated carcinomatosis of the bone marrow caused by AGC. We initiated combination chemotherapy with S-1 and cisplatin, which lead to a significant improvement of the DIC and eosinophilia, and the patient was finally discharged. The primary symptoms of DIC and eosinophilia were both considered to be caused by AGC, and we successfully treated the patient's critical condition.
authors.affiliation: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Takeda
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Takehiko
authors.initials: T
authors.lastname: Tsumura
authors.forename: Akira
authors.initials: A
authors.lastname: Sekikawa
authors.forename: Takanori
authors.initials: T
authors.lastname: Maruo
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Okabe
authors.forename: Toru
authors.initials: T
authors.lastname: Kimura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Wakasa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Osaki
mesh_terms: D000368:Aged; D000855:Anorexia / Q000209:etiology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D019046:Bone Marrow Neoplasms / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy / Q000209:etiology*; D004338:Drug Combinations; D004802:Eosinophilia / Q000209:etiology*; D005260:Female; D006801:Humans; D010094:Oxonic Acid / Q000008:administration & dosage; D011693:Purpura / Q000209:etiology; D013274:Stomach Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005641:Tegafur / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin