title: Association between omentin levels and insulin resistance in pregnancy.
abstract: OBJECTIVE
  Omentin is a new adipokine secreted mainly from visceral adipose tissue. Serum omentin is found to be reduced in patients with impaired glucose tolerance, type 2 diabetes mellitus, obesity and insulin resistant states. Despite the fact that pregnancy is also characterized with hyperinsulinemia, literature is lacking about data of omentin levels and its association with insulin resistance in pregnant women. We aimed to evaluate the association of omentin levels and insulin resistance in pregnant women and to compare these levels with those of non-pregnant, non-diabetic women.
  
  
  METHODS
  Uncomplicated pregnant women who admit to our outpatient clinics for routine follow-up were included in the study group. Non-pregnant women without diabetes mellitus were served as control group. Fasting glucose, insulin, omentin levels and HOMA IR were recorded. SPSS 15.0 for Windows was used for statistical analysis.
  
  
  RESULTS
  There were 36 pregnant women in the study group and 37 healthy, non-pregnant women in the control group. Serum omentin and fasting glucose levels were significantly decreased and fasting insulin was significantly increased in the study group compared to control group.
  
  
  CONCLUSIONS
  Omentin might be an indicator of insulin resistance in pregnant women. Larger prospective studies are needed to claim whether omentin can have a clinical use for diagnosis of gestational diabetes mellitus.
authors.affiliation: Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Aktas
authors.affiliation: Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Alcelik
authors.affiliation: Department of Obstetrics and Gynecology, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Ozlu
authors.affiliation: Department of Biochemistry, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Tosun
authors.affiliation: Department of Biochemistry, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: B K
authors.initials: BK
authors.lastname: Tekce
authors.affiliation: Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Savli
authors.affiliation: Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Tekce
authors.affiliation: Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Dikbas
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D037102:Lectins / Q000097:blood*; D008875:Middle Aged; D011247:Pregnancy / Q000097:blood / Q000378:metabolism*; D011263:Pregnancy Trimester, Third
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins