title: Choroidal thickness in patients with reticular pseudodrusen using 3D 1060-nm OCT maps.
abstract: OBJECTIVE
  To map and analyze choroidal thickness (ChT) in AMD patients with reticular pseudodrusen (RPD) using three-dimensional (3D) 1060-nm optical coherence tomography (OCT).
  
  
  METHODS
  Fifty eyes from 25 patients with RPD were grouped according to the severity of AMD and the presence of RPD. All patients were imaged by high-speed (60,000 A-scans/s) 3D 1060-nm OCT over a 36 × 36° field of view. Choroidal thickness maps were automatically generated and compared with RPD areas visualized by fundus autofluorescence and infrared imaging. Retinal thickness maps, ChT maps, Haller's and Sattler's layer thickness were statistically analyzed between groups.
  
  
  RESULTS
  The mean ± SD (micrometers) subfoveal ChT was 201 ± 88 μm, 145 ± 48 μm, and 271 ± 130 μm for dry AMD with RPD, wet AMD with RPD, and eyes with wet AMD and no RPD, respectively. Choroidal thickness maps demonstrated the most significant choroidal thinning within eyes with wet AMD and RPD. Sattler's and Haller's layer thickness differed across the Early Treatment Diabetic Retinopathy Study grid when compared between eyes with and without RPD. Within eyes with RPD, ChT maps visualized that ChT was thicker below RDP areas than non-RPD areas.
  
  
  CONCLUSIONS
  The 3D 1060-nm OCT choroidal maps over a large field of view offer noninvasive visualization for demonstrating local thickening correlation with RPD within each eye and overall thinning owing to AMD severity and RPD. This choroidal thinning was most striking in Sattler's layer, suggesting a choroidopathy of this vascular layer.
authors.affiliation: Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Department of Ophthalmology, Rudolph Foundation Clinic, Vienna, Austria.
authors.forename: Paulina
authors.initials: P
authors.lastname: Haas
authors.forename: Marieh
authors.initials: M
authors.lastname: Esmaeelpour
authors.forename: Siamak
authors.initials: S
authors.lastname: Ansari-Shahrezaei
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Drexler
authors.forename: Susanne
authors.initials: S
authors.lastname: Binder
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000473:pathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D015593:Retinal Drusen / Q000175:diagnosis*; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: age-related macular degeneration; choroidal neovascularization; choroidal thickness maps; optical coherence tomography; retina