title: [The taxonomy of the Issyk-Kul virus (ISKV, Bunyaviridae, Nairovirus), the etiologic agent of the Issyk-Kul fever isolated from bats (Vespertilionidae) and ticks Argas (Carios) vespertilionis (Latreille, 1796)].
abstract: The Issyk-Kul virus (etiological agent of the Issyk-Kul fever) was originally isolated from bats (Nyctalus noctula Schreber, 1774 (Chiroptera: Vespertilionidae)) and their parasites ticks (Argas (Carios) vespertilionis Latreille, 1796 (Parasitiformes: Argasidae)) in Kirghizia. Sporadic cases and epidemics of the Issyk-Kul fever are observed in Central Asia since 1979. The ISKV genome was de novo sequenced using the next-generation sequencing technology. According to the molecular-genetic and phylogenetic analysis, the ISKV is a member of a novel group in the genus Nairovirus (Bunyaviridae). Based on the data obtained, molecular-genetic methods can be used for ISKV detection (PCR) for the Issyk-Kul fever monitoring and diagnosis in the endemic areas.
authors.forename: S V
authors.initials: SV
authors.lastname: Al'khovskiĭ
authors.forename: D K
authors.initials: DK
authors.lastname: L'vov
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Shchelkanov
authors.forename: A M
authors.initials: AM
authors.lastname: Shchetinin
authors.forename: P G
authors.initials: PG
authors.lastname: Deriabin
authors.forename: E I
authors.initials: EI
authors.lastname: Samokhvalov
authors.forename: A K
authors.initials: AK
authors.lastname: Gitel'man
authors.forename: A G
authors.initials: AG
authors.lastname: Botikov
mesh_terms: D000818:Animals; D026864:Argas / Q000821:virology*; D001921:Brain / Q000821:virology; D002044:Bunyaviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D002685:Chiroptera / Q000821:virology*; D015698:Genomic Library; D007707:Kyrgyzstan / Q000453:epidemiology; D016855:Nairovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid