title: Frequencies of dendritic cells and Toll-like receptor 3 in neonates born to HBsAg-positive mothers with different HBV serological profiles.
abstract: To investigate the frequencies of dendritic cells (DCs) and Toll-like receptor 3 (TLR3) in neonates of HBsAg-positive mothers with different HBV serological profiles, we conducted a study in Taiyuan, China. The study included 144 HBsAg-positive mothers and their neonates. The frequencies of DCs and TLR3 were determined using four-colour flow-cytometric analysis. DC and TLR3 frequencies were not related to HBV intrauterine transmission, maternal HBeAg positivity, maternal HBV DNA positivity and HBeAg/HBV DNA double-positivity. The plasmacytoid dendritic cell (pDC) frequencies in neonates whose maternal HBV DNA was >5 × 107 copies/ml decreased significantly compared to that in neonates whose maternal HBV DNA was ⩽5 × 107 copies/ml (Z = - 2·170, P = 0·03) or whose maternal HBV DNA was negative (Z = - 1·981 P = 0·048). This study suggests that neonatal pDC frequencies decrease when maternal HBV DNA loads are >5 × 107 copies/ml.
authors.affiliation: Department of Epidemiology, School of Public Health,Shanxi Medical University,Taiyuan, Shanxi,P.R. China.
authors.forename: J
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Epidemiology, School of Public Health,Shanxi Medical University,Taiyuan, Shanxi,P.R. China.
authors.forename: Y
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Epidemiology, School of Public Health,Shanxi Medical University,Taiyuan, Shanxi,P.R. China.
authors.forename: Z
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Epidemiology, School of Public Health,Shanxi Medical University,Taiyuan, Shanxi,P.R. China.
authors.forename: L R
authors.initials: LR
authors.lastname: Zhang
authors.affiliation: Obstetrics and Gynaecology Department,the Third People Hospital of Taiyuan City,Taiyuan, Shanxi,P.R. China.
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health,Shanxi Medical University,Taiyuan, Shanxi,P.R. China.
authors.forename: S P
authors.initials: SP
authors.lastname: Wang
mesh_terms: D002681:China; D004279:DNA, Viral / Q000097:blood; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006509:Hepatitis B / Q000276:immunology* / Q000635:transmission*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D051196:Toll-Like Receptor 3 / Q000032:analysis*
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; C495344:TLR3 protein, human; D051196:Toll-Like Receptor 3