title: Quinone derivatives from the genus Rubia and their bioactivities.
abstract: The extracts and phytochemicals of the genus Rubia have drawn much attention due to their potent effects; among them, naphthoquinone and cyclopeptide derivatives, with significant biological activities, have great potential to be developed to new drugs. This review updates and compiles a total of 142 quinone derivatives including anthraquinone and naphthoquinone derivatives, occuring in twelve Rubia species. These compounds were listed together with their sources, melting points, bioactivities, as well as 112 corresponding references. Furthermore, the structureactivity relationships of these quinone derivatives were discussed.
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China, (phone: +86-1084738640; fax: +86-1082686933).
authors.forename: Kuo
authors.initials: K
authors.lastname: Xu
authors.forename: Penglong
authors.initials: P
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Congmin
authors.initials: C
authors.lastname: Liu
authors.forename: Shixun
authors.initials: S
authors.lastname: Xu
authors.forename: Yatao
authors.initials: Y
authors.lastname: Cheng
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Haimin
authors.initials: H
authors.lastname: Lei
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D006518:Hepatitis Viruses / Q000187:drug effects; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology; D011809:Quinones / Q000737:chemistry* / Q000494:pharmacology; D045470:Rubia / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D010975:Platelet Aggregation Inhibitors; D011809:Quinones
keywords: Anthraquinone derivatives; Biological activity; Naphthoquinone derivatives; Quinones; Rubia species