title: Protective effect of oxytocin on ovarian ischemia-reperfusion injury in rats.
abstract: Oxytocin (OT), a neurohypophysial nonapeptide, plays dual role as a neurotransmitter/neuromodulator and a hormone. It has also well known protective properties against ischemia/reperfusion organ damage. This study investigated the effect of OT on experimentally induced ovarian torsion/de-torsion ischemia/reperfusion (I/R) injury in rats. Sprague-Dawley rats were assigned to five treatment groups (n=7/group): Group 1, sham-operated; Group 2, torsion; Group 3, 80 IU/kg of OT administration 30 min prior to torsion; Group 4, torsion/de-torsion; and Group 5, torsion followed by 80 IU/kg of OT administration 30 min prior to de-torsion. OT administration significantly decreased the tissue malondialdehyde (MDA) levels in both the torsion and OT group (Group 3), and torsion/de-torsion OT group (Group 5) in comparison with the torsion-only group (Group 2) and torsion/de-torsion group (Group 4). Histopathological finding scores including follicular degeneration, edema, hemorrhage, vascular congestion, and infiltration by inflammatory cells were found to be significantly decreased in the torsion and OT group (Group 3), and torsion/de-torsion OT group (Group 5) when compared with the torsion-only group (Group 2) and torsion/de-torsion group (Group 4). In conclusion, these results, verified with histopathologic evaluation and biochemical assays, suggest a probable protective role for OT in ischemia and I/R injury in rat ovaries.
authors.affiliation: Department of Obstetrics and Gynecology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Akdemir
authors.affiliation: Department of Physiology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Oytun
authors.initials: O
authors.lastname: Erbas
authors.affiliation: Department of Obstetrics and Gynecology, Kent Hospital, Izmir, Turkey. Electronic address: funda.gode@gmail.com.
authors.forename: Funda
authors.initials: F
authors.lastname: Gode
authors.affiliation: Department of Obstetrics and Gynecology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Mete
authors.initials: M
authors.lastname: Ergenoglu
authors.affiliation: Department of Obstetrics and Gynecology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Yeniel
authors.affiliation: Department of Histology and Embryology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Oltulu
authors.affiliation: Department of Histology and Embryology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Altug
authors.initials: A
authors.lastname: Yavasoglu
authors.affiliation: Department of Physiology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Taskiran
mesh_terms: D000818:Animals; D005260:Female; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000378:metabolism; D010053:Ovary / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D018384:Oxidative Stress; D010121:Oxytocin / Q000494:pharmacology* / Q000627:therapeutic use; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*
chemical_list: D008315:Malondialdehyde; D010121:Oxytocin
keywords: Ischemia/reperfusion; Ovary; Oxytocin; Protection; Torsion