title: Imaging of nitroxides at 250MHz using rapid-scan electron paramagnetic resonance.
abstract: Projections for 2D spectral-spatial images were obtained by continuous wave and rapid-scan electron paramagnetic resonance using a bimodal cross-loop resonator at 251MHz. The phantom consisted of three 4mm tubes containing different (15)N,(2)H-substituted nitroxides. Rapid-scan and continuous wave images were obtained with 5min total acquisition times. For comparison, images also were obtained with 29s acquisition time for rapid scan and 15min for continuous wave. Relative to continuous wave projections obtained for the same data acquisition time, rapid-scan projections had significantly less low-frequency noise and substantially higher signal-to-noise at higher gradients. Because of the improved image quality for the same data acquisition time, linewidths could be determined more accurately from the rapid-scan images than from the continuous wave images.
authors.affiliation: Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, United States; Center for EPR Imaging in Vivo Physiology, University of Denver, Denver, CO 80208, United States.
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Biller
authors.affiliation: Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, United States; Center for EPR Imaging in Vivo Physiology, University of Denver, Denver, CO 80208, United States.
authors.forename: Mark
authors.initials: M
authors.lastname: Tseitlin
authors.affiliation: Center for EPR Imaging in Vivo Physiology, University of Denver, Denver, CO 80208, United States; School of Engineering and Computer Science, University of Denver, Denver, CO 80208, United States.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Quine
authors.affiliation: Center for EPR Imaging in Vivo Physiology, University of Denver, Denver, CO 80208, United States; School of Engineering and Computer Science, University of Denver, Denver, CO 80208, United States.
authors.forename: George A
authors.initials: GA
authors.lastname: Rinard
authors.affiliation: Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, United States; Center for EPR Imaging in Vivo Physiology, University of Denver, Denver, CO 80208, United States.
authors.forename: Hilary A
authors.initials: HA
authors.lastname: Weismiller
authors.affiliation: Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, United States; Center for EPR Imaging in Vivo Physiology, University of Denver, Denver, CO 80208, United States.
authors.forename: Hanan
authors.initials: H
authors.lastname: Elajaili
authors.affiliation: Center for Biomedical Engineering and Technology, University of Maryland, School of Medicine, Baltimore, MD 21201, United States; Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201, United States.
authors.forename: Gerald M
authors.initials: GM
authors.lastname: Rosen
authors.affiliation: Center for Biomedical Engineering and Technology, University of Maryland, School of Medicine, Baltimore, MD 21201, United States; Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, United States.
authors.forename: Joseph P Y
authors.initials: JP
authors.lastname: Kao
authors.affiliation: Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, United States; Center for EPR Imaging in Vivo Physiology, University of Denver, Denver, CO 80208, United States.
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Eaton
authors.affiliation: Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, United States; Center for EPR Imaging in Vivo Physiology, University of Denver, Denver, CO 80208, United States. Electronic address: geaton@du.edu.
authors.forename: Gareth R
authors.initials: GR
authors.lastname: Eaton
mesh_terms: D004578:Electron Spin Resonance Spectroscopy / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008280:Magnetics / Q000295:instrumentation*; D057054:Molecular Imaging / Q000295:instrumentation*; D009589:Nitrogen Oxides / Q000032:analysis* / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014159:Transducers
chemical_list: D009589:Nitrogen Oxides
keywords: 250MHz EPR; Imaging; Nitroxide; Rapid scan