title: Identification of anisodamine tablets by Raman and near-infrared spectroscopy with chemometrics.
abstract: Vibrational spectroscopy including Raman and near-infrared (NIR) spectroscopy has become an attractive tool for pharmaceutical analysis. In this study, effective calibration models for the identification of anisodamine tablet and its counterfeit and the distinguishment of manufacturing plants, based on Raman and NIR spectroscopy, were built, respectively. Anisodamine counterfeit tablets were identified by Raman spectroscopy with correlation coefficient method, and the results showed that the predictive accuracy was 100%. The genuine anisodamine tablets from 5 different manufacturing plants were distinguished by NIR spectroscopy using partial least squares discriminant analysis (PLS-DA) models based on interval principal component analysis (iPCA) method. And the results showed the recognition rate and rejection rate were 100% respectively. In conclusion, Raman spectroscopy and NIR spectroscopy combined with chemometrics are feasible and potential tools for rapid pharmaceutical tablet discrimination.
authors.affiliation: Key Laboratory of Chemical Biology of Natural Products (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhuaxi Road, Jinan 250012, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Li
authors.affiliation: Key Laboratory of Chemical Biology of Natural Products (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhuaxi Road, Jinan 250012, China.
authors.forename: Hengchang
authors.initials: H
authors.lastname: Zang
authors.affiliation: Shandong Institute for Food and Drug Control, No. 2749, Xinluo Avenue, High-tech Zone, Jinan 250101, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Shandong Institute for Food and Drug Control, No. 2749, Xinluo Avenue, High-tech Zone, Jinan 250101, China.
authors.forename: Dejun
authors.initials: D
authors.lastname: Chen
authors.affiliation: Shandong Institute for Food and Drug Control, No. 2749, Xinluo Avenue, High-tech Zone, Jinan 250101, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: Key Laboratory of Chemical Biology of Natural Products (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhuaxi Road, Jinan 250012, China. Electronic address: fswang@sdu.edu.cn.
authors.forename: Fengshan
authors.initials: F
authors.lastname: Wang
mesh_terms: D058110:Counterfeit Drugs / Q000032:analysis*; D012991:Solanaceous Alkaloids / Q000032:analysis*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013607:Tablets
chemical_list: D058110:Counterfeit Drugs; D012991:Solanaceous Alkaloids; D013607:Tablets; C003922:anisodamine
keywords: Chemometrics; Identification of anisodamine tablet; Near-infrared spectroscopy; Raman spectroscopy