title: Circulating angiogenic and inflammatory cytokine responses to acute aerobic exercise in trained and sedentary young men.
abstract: OBJECTIVE
  Endurance exercise training can ameliorate many cardiovascular and metabolic disorders and attenuate responses to inflammatory stimuli. The purpose of this study was to determine whether the angiogenic and pro-inflammatory cytokine response to acute endurance exercise differs between endurance-trained and sedentary young men.
  
  
  METHODS
  Ten endurance-trained and ten sedentary healthy young men performed 30 min of treadmill running at 75 % VO2max with blood sampling before and after exercise. Plasma concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), placental growth factor (PlGF), and soluble VEGF receptor-1 (sFlt-1) were measured by multiplex ELISA.
  
  
  RESULTS
  Acute exercise increased IL-6 by 165 % (P < 0.05), IL-8 by 32 % (P < 0.05), PlGF by ~16 % (P < 0.05), sFlt-1 by 36 % (P < 0.001), and tended to increase bFGF by ~25 % (P = 0.06) in main effects analyses. TNF-α and VEGF did not change significantly with exercise in either group. Contrary to our hypothesis, there were no significant differences in TNF-α, IL-6, VEGF, bFGF, PlGF, or sFlt-1 between groups before or after acute exercise; however, there was a tendency for IL-8 concentrations to be higher in endurance-trained subjects compared to sedentary subjects (P = 0.06).
  
  
  CONCLUSIONS
  These results indicate that 30 min of treadmill running at 75 % VO2max produces a systemic angiogenic and inflammatory reaction, but endurance exercise training does not appear to significantly alter these responses in healthy young men.
authors.affiliation: University of Maryland, College Park, MD, USA.
authors.forename: Rian Q
authors.initials: RQ
authors.lastname: Landers-Ramos
authors.forename: Nathan T
authors.initials: NT
authors.lastname: Jenkins
authors.forename: Espen E
authors.initials: EE
authors.lastname: Spangenburg
authors.forename: James M
authors.initials: JM
authors.lastname: Hagberg
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Prior
mesh_terms: D000293:Adolescent; D000328:Adult; D042501:Angiogenic Proteins / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D015444:Exercise; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D010101:Oxygen Consumption; D010807:Physical Endurance; D012420:Running; D057185:Sedentary Behavior; D013997:Time Factors; D055815:Young Adult
chemical_list: D042501:Angiogenic Proteins; D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators