title: Cocaine-and-Amphetamine Regulated Transcript (CART) peptide attenuates dopamine- and cocaine-mediated locomotor activity in both male and female rats: lack of sex differences.
abstract: Cocaine-and-Amphetamine Regulated Transcript peptide (CART peptide) is known for having an inhibitory effect on dopamine (DA)- and cocaine-mediated actions and is postulated to be a homeostatic, regulatory factor in the nucleus accumbens (NAc). Some sex differences in cocaine-mediated locomotor activity (LMA) and in the expression and function of CART peptide have been reported. However, it is not known if the inhibitory effect of CART peptide on cocaine-mediated LMA is sexually dimorphic. In this study, the effects of CART 55-102 on LMA due to intra-NAc DA and i.p. cocaine were determined in male and female Sprague-Dawley rats. The results show that CART 55-102 blunted or reduced both the DA- and cocaine-induced LMA in both males and females. In conclusion, CART peptide is effective in blunting DA- and cocaine-mediated LMA in both males and females.
authors.affiliation: Yerkes National Primate Research Center of Emory University, 954 Gatewood Rd. NE, Atlanta, GA 30329, USA. Electronic address: femijob@gmail.com.
authors.forename: Martin O
authors.initials: MO
authors.lastname: Job
authors.affiliation: Yerkes National Primate Research Center of Emory University, 954 Gatewood Rd. NE, Atlanta, GA 30329, USA.
authors.forename: Joanna
authors.initials: J
authors.lastname: Perry
authors.affiliation: Yerkes National Primate Research Center of Emory University, 954 Gatewood Rd. NE, Atlanta, GA 30329, USA.
authors.forename: Li L
authors.initials: LL
authors.lastname: Shen
authors.affiliation: Yerkes National Primate Research Center of Emory University, 954 Gatewood Rd. NE, Atlanta, GA 30329, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kuhar
mesh_terms: D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D030762:Estrous Cycle / Q000502:physiology; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism*; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
chemical_list: D018765:Dopamine Uptake Inhibitors; D009419:Nerve Tissue Proteins; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein; D003042:Cocaine; D004298:Dopamine
keywords: CART55-102; Cocaine; Dopamine; Locomotion; Nucleus accumbens; Phrases Cocaine-and-Amphetamine Regulated Transcript peptide; Sex differences