title: Profile of prothrombotic factors in Indian children with ischemic stroke.
abstract: This study was undertaken in view of paucity of data regarding the profile of prothrombotic factors in children with ischemic stroke. Sixty-four children with ischemic stroke were prospectively evaluated for prothrombotic factors over a 2 year period. The blood samples were analyzed for protein C (PC), protein S (PS), activated protein C resistance (APCR), factor V Leiden (FVL), anti-thrombin-III (AT-III), lipoprotein (a) [Lp(a)], lupus anticoagulant (LA), anti-cardiolipin antibodies (aCL) immunoglobulin (Ig) M and IgG, homocysteine, and methylenetetrahydrofolate reductase (MTHFR) at least 3 months after the onset of stroke. At least one prothrombotic factor was identified in 45.3% children (29/64). These included hyperhomocysteinemia (11/64), PC deficiency (9/64), aCL (8/64), PS deficiency (5/64), APCR (3/64), AT-III deficiency (2/64) and LA (1/64). Multiple factors were coexistent in 17.2% (11/64). The prevalence of PC deficiency, PS deficiency and co-existence of multiple abnormalities observed were similar to the published literature. Elevated Lp(a) and APCR were less prevalent. FVL and MTHFR were not seen in any of the study children. Forty-five percent of children had at least one prothrombotic abnormality. Hyperhomocysteinemia, PC deficiency, aCL and PS deficiency were the most frequent prothrombotic abnormalities.
authors.affiliation: Rainbow Hospital for Women and Children, Banjara Hills, Hyderabad, India; Division of Neurology, Department of Pediatrics, All India Institute of Medical Sciences, Sri Aurobindo Marg, Ansari Nagar, New Delhi 110029, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Konanki
authors.affiliation: Division of Neurology, Department of Pediatrics, All India Institute of Medical Sciences, Sri Aurobindo Marg, Ansari Nagar, New Delhi 110029, India. Electronic address: sheffaligulati@gmail.com.
authors.forename: Sheffali
authors.initials: S
authors.lastname: Gulati
authors.affiliation: Department of Hematology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Renu
authors.initials: R
authors.lastname: Saxena
authors.affiliation: Department of Radiodiagnosis, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Gupta
authors.affiliation: Department of Radiodiagnosis, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Ashu
authors.initials: A
authors.lastname: Seith
authors.affiliation: Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Cardiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Anita
authors.initials: A
authors.lastname: Saxena
authors.affiliation: Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Madhulika
authors.initials: M
authors.lastname: Kabra
authors.affiliation: Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India; Indraprastha Apollo Hospital, New Delhi, India.
authors.forename: Veena
authors.initials: V
authors.lastname: Kalra
authors.affiliation: Department of Cardiac Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Ramakrishnan
authors.initials: R
authors.lastname: Lakshmy
mesh_terms: D000293:Adolescent; D001774:Blood Chemical Analysis; D002545:Brain Ischemia / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D008297:Male; D011446:Prospective Studies; D020521:Stroke / Q000097:blood*
keywords: Cerebrovascular disease; Childhood stroke; Children; Ischemic stroke; Prothrombotic factors