title: Chemical constituents of aerial parts and roots of Pycnanthemum flexuosum.
abstract: An extract of whole plants of Pycnanthemum flexuosum showed an inhibitory effect on hyaluronidase activity. From an 80% acetone extract of aerial parts, 3-[(3E)-4-phenylbut-3-enoylamino]propionic acid, 3-O-β-D-glucuronopyranosyl-echinocystic acid 28-O-β-D-xylopyranosyl-(1→3)-[3,4-diacetyl-β-D-xylopyranosyl-(1→4)]-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl ester, vanillic acid 1-O-[(5-O-syringoyl)-β-D-apiofuranosyl]-(1→2)-β-D-glucopyranoside, and (4S,5R)-4-hydroxy-5-phenyl-tetrahydrofuran-2-one were isolated together with 30 known compounds. Six known compounds were isolated from an 80% acetone extract of roots, and eritrichin was revealed as a hyaluronidase inhibitor in P. flexuosum.
authors.affiliation: Department of Pharmacognosy, Tohoku Pharmaceutical University.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Murata
authors.forename: Mari
authors.initials: M
authors.lastname: Nakano
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyase
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshizaki
mesh_terms: D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D010936:Plant Extracts; D006821:Hyaluronoglucosaminidase