title: A study on the antidepressant effect of Danzhi Xiaoyao Powder.
abstract: BACKGROUND
  Danzhi Xiaoyao Powder is used for regulating qi and blood, soothing liver-qi stagnation and adjusting the function of internal organs in the clinical. The objective of this paper was to study the antidepressant effect of Danzhi Xiaoyao Powder.
  
  
  METHODS
  Experimental animals were grouped and given different doses of xiaoyao powder and Fluoxetine Hydrochloride tablets respectively. Mouse models of behavioural despair such as tail suspension test and forced swimming test were used to evaluate the antidepressant effect of Xiaoyao.
  
  
  RESULTS
  Danzhi Xiaoyao Powder could shorten the immobility time of mice in the tail suspension and forced swimming despair models, and had a significant effect on them, while having no significant effect on locomotor activity in mice.
  
  
  CONCLUSIONS
  Danzhi Xiaoyao Powder has a good antidepressant effect. The material basis and physiological and biochemical mechanisms of its action should be determined by further study.
authors.affiliation: Youth & Children Research Institute, China Youth University for Political Sciences, Beijing 100089, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Lun
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D019417:Hindlimb Suspension; D019684:Magnoliopsida; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D008517:Phytotherapy; D013315:Stress, Psychological / Q000188:drug therapy*; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D004365:Drugs, Chinese Herbal; C531141:danzhi xiaoyao
keywords: Danzhi Xiaoyao Powder; anti-depression; forced swimming test; tail suspension test