title: Proteome reactivity profiling for the discrimination of pathogenic bacteria.
abstract: Diverse proteome reactivity profiles were obtained using small-molecule electrophiles. Based on the cross-reactivity profile, each protein generated a unique reactivity fingerprint. Here, we report the first proteome reactivity signature-based discrimination of 11 bacteria. Perfect differentiation of 11 bacteria can be achieved using 2 benzyl-halide probes.
authors.affiliation: Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seoul, 136-791, Korea. junseoklee@kist.re.kr.
authors.forename: Jun-Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Young-Hwa
authors.initials: YH
authors.lastname: Yoo
authors.forename: Jihye
authors.initials: J
authors.lastname: Kang
authors.forename: Won Seok
authors.initials: WS
authors.lastname: Han
authors.forename: Jin Kak
authors.initials: JK
authors.lastname: Lee
authors.forename: Chang No
authors.initials: CN
authors.lastname: Yoon
mesh_terms: D001419:Bacteria / Q000302:isolation & purification* / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D005456:Fluorescent Dyes / Q000737:chemistry; D015335:Molecular Probes / Q000737:chemistry; D025341:Principal Component Analysis; D020543:Proteome / Q000032:analysis* / Q000378:metabolism; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D015335:Molecular Probes; D020543:Proteome