title: Disclosure of microbicide gel use to sexual partners: influence on adherence in the CAPRISA 004 trial.
abstract: Young women in sub-Saharan Africa are disproportionately affected by HIV, making the development of women initiated and controlled methods of prevention, including microbicides, a priority. Adherence is pivotal to microbicide efficacy and partner related factors are known to impact adherence. An analysis of disclosure of gel use to sexual partners and adherence in CAPRISA 004 women was conducted to better understand this relationship. Partner disclosure was significantly associated with a modest 4.2 % increased adherence (71.0 vs. 66.8 %, p = 0.03). Most women rated the experience of disclosure as positive, despite 6.7 % of partners expressing a negative reaction.Participants who disclosed were more likely to reside with their regular partner (14.4 vs. 8.4 %; p = 0.01) and reported consistent condom use at baseline (32.9 vs. 20.9 %; p < 0.01). Partner disclosure needs to be better understood as a potential facilitator or barrier to microbicide adherence.
authors.affiliation: Centre for the AIDS Program of Research in South Africa, Doris, Duke Medical Research Institute, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, 2nd Floor, Private Bag X7, Congella, 4013, South Africa, mngadik@ukzn.ac.za.
authors.forename: Kathryn Therese
authors.initials: KT
authors.lastname: Mngadi
authors.forename: Silvia
authors.initials: S
authors.lastname: Maarschalk
authors.forename: Anneke C
authors.initials: AC
authors.lastname: Grobler
authors.forename: Leila E
authors.initials: LE
authors.lastname: Mansoor
authors.forename: Janet A
authors.initials: JA
authors.lastname: Frohlich
authors.forename: Bernadette
authors.initials: B
authors.lastname: Madlala
authors.forename: Nelisiwe
authors.initials: N
authors.lastname: Ngcobo
authors.forename: Salim S
authors.initials: SS
authors.lastname: Abdool Karim
authors.forename: Quarraisha
authors.initials: Q
authors.lastname: Abdool Karim
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D017280:Condoms / Q000706:statistics & numerical data; D030881:Disclosure; D005260:Female; D005782:Gels; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D007407:Interviews as Topic; D055118:Medication Adherence / Q000523:psychology*; D063065:Organophosphonates / Q000008:administration & dosage*; D012725:Sexual Behavior / Q000523:psychology; D012747:Sexual Partners; D012959:Socioeconomic Factors; D013019:South Africa; D011795:Surveys and Questionnaires; D000068698:Tenofovir; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D005782:Gels; D063065:Organophosphonates; D000068698:Tenofovir; D000225:Adenine