title: Role of minimal residual disease and chimerism after reduced-intensity and myeloablative allo-transplantation in acute myeloid leukemia and high-risk myelodysplastic syndrome.
abstract: We evaluated the impact of detection of minimal residual disease by flow cytometry (FCMRD) and CD3 chimerism in relapse in a cohort of 87 patients with acute myeloid leukemia or myelodysplastic syndrome undergoing stem cell transplantation. Patients with a positive FCMRD at day +100 after transplantation showed higher relapse rates and worse overall survival. In multivariate analysis, a positive FCMRD after transplantation was a significant predictor of relapse. Mixed chimerism showed a trend to statistical signification. We conclude that FCMRD at day 100 after SCT is the best predictor of relapse after SCT in patients with aggressive myeloid malignancies.
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Universitario Central de Asturias, Oviedo, Spain. Electronic address: Teresa.bernal@sespa.princast.es.
authors.forename: Teresa
authors.initials: T
authors.lastname: Bernal
authors.affiliation: Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Diez-Campelo
authors.affiliation: Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Vicky
authors.initials: V
authors.lastname: Godoy
authors.affiliation: Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Rojas
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Colado
authors.affiliation: Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Alcoceba
authors.affiliation: Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Marcos
authors.initials: M
authors.lastname: González
authors.affiliation: Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Vidriales
authors.affiliation: Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Fermín M
authors.initials: FM
authors.lastname: Sánchez-Guijo
authors.affiliation: Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: López-Corral
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Elisa
authors.initials: E
authors.lastname: Luño
authors.affiliation: Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Consuelo
authors.initials: C
authors.lastname: del Cañizo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017252:CD3 Complex / Q000235:genetics; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000401:mortality* / Q000628:therapy; D018365:Neoplasm, Residual / Q000175:diagnosis*; D012008:Recurrence; D012307:Risk Factors; D018183:Transplantation Chimera / Q000276:immunology*; D014184:Transplantation, Homologous
chemical_list: D017252:CD3 Complex
keywords: Acute myeloid leukemia; Allogeneic stem cell transplantation; Chimerism; Minimal residual disease; Myelodysplastic syndrome; Relapse