title: Protective action ofCitrullus colocynthisseed extracts against the deleterious effect of streptozotocin on bothin vitroglucose-stimulated insulin release from rat pancreatic islets andin vivoglucose homeostasis.
abstract: Citrullus colocynthisextracts improve glucose homeostasis in alloxan- or streptozotocin (STZ)-induced diabetic rats. Little is known, however, regarding the protective effect of these extracts against the β-cytotoxic action of STZ. In the present study, an H2O-methanol extract was found to suppress the inhibition of glucose-stimulated insulin secretion by STZ in rat-isolated pancreatic islets. Similarly, when an aqueous extract fromCitrullus colocynthisseeds was injected daily for 21 days prior to STZ administration, the perturbation of glucose homeostasis otherwise generated by the β-cytotoxic agent was minimized in rats.
authors.affiliation: Laboratory of Antibiotic and Antifungal Physico-Chemistry, Synthesis and Biological Activity, Faculty of Sciences, University Abou Bekr Belakaïd, Tlemcen, Algeria ; ; Laboratory of Experimental Hormonology, Free University of Brussels, Brussels, Belgium.
authors.forename: Nabila
authors.initials: N
authors.lastname: Benariba
authors.affiliation: Laboratory of Antibiotic and Antifungal Physico-Chemistry, Synthesis and Biological Activity, Faculty of Sciences, University Abou Bekr Belakaïd, Tlemcen, Algeria ;
authors.forename: Wafaa
authors.initials: W
authors.lastname: Bellakdhar
authors.affiliation: Laboratory of Antibiotic and Antifungal Physico-Chemistry, Synthesis and Biological Activity, Faculty of Sciences, University Abou Bekr Belakaïd, Tlemcen, Algeria ;
authors.forename: Rabeh
authors.initials: R
authors.lastname: Djaziri
authors.affiliation: Laboratory of Experimental Hormonology, Free University of Brussels, Brussels, Belgium.
authors.forename: Emeline
authors.initials: E
authors.lastname: Hupkens
authors.affiliation: Laboratory of Experimental Hormonology, Free University of Brussels, Brussels, Belgium.
authors.forename: Karim
authors.initials: K
authors.lastname: Louchami
authors.affiliation: Laboratory of Experimental Hormonology, Free University of Brussels, Brussels, Belgium.
authors.forename: Willy J
authors.initials: WJ
authors.lastname: Malaisse
keywords: Citrullus colocynthis extracts; glucose-stimulated insulin release; glycemia; rat isolated pancreatic islets; streptozotocin