title: Prediction rule for estimating advanced colorectal neoplasm risk in average-risk populations in southern Jiangsu Province.
abstract: OBJECTIVE
  The aim of this study was to establish the risk scoring system towards the advanced colorectal neoplasm (CN) risk in the average-risk populations in the southern Jiangsu Province, and to evaluate the screening efficacy.
  
  
  METHODS
  Totally 905 cases of the average-risk populations who received the colonoscopy were selected as the objective. The multivariate logistic regression analysis method was used to establish the scoring system towards the occurrence risk of the advanced tumor, and its screening efficacy was evaluated through the prediction consistency, distinguishing ability and screening accuracy.
  
  
  RESULTS
  The scoring system consisted of five variables, namely age, gender, coronary heart disease, egg intake and stool frequency. The results revealed that it had good prediction consistency (P=0.205) and distinguishing ability [the area under the receiver operating characteristic (ROC) curve was 0.75, with 95% confidence interval (95% CI) of 0.69-0.82]. Thus, 2.5 points was set as the screening cutoff value, and its sensitivity, specificity, accuracy, positive predictive value, negative predictive value, positive likelihood ratio and negative likelihood ratio were 93.8%, 47.6%, 50.1%, 9.1%, 99.3%, 1.79 and 0.13, respectively.
  
  
  CONCLUSIONS
  The established scoring system had good screening efficacy, and can be used as the screening tool applying to the CN screening within the average-risk populations in the southern Jiangsu Province.
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Yixing 214200, China.
authors.forename: Guochang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Yixing 214200, China.
authors.forename: Boneng
authors.initials: B
authors.lastname: Mao
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Yixing 214200, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Pan
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Yixing 214200, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Yixing 214200, China.
authors.forename: Xinfang
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Yixing 214200, China.
authors.forename: Yueji
authors.initials: Y
authors.lastname: Ning
keywords: Colorectal neoplasm (CN); colonoscopy; cross-sectional studies; risk factor; screening