title: Targeting IL-10 in auto-immune diseases.
abstract: IL-10 is a multifunctional cytokine secreted by a variety of cells. It not only inhibits activation of monocyte/macrophage system and synthesis of monocyte cytokine and inflammatory cytokine but also promotes the proliferation and maturation of non-monocyte-dependent T cell, stimulating proliferation of antigen-specific B cell. Increasing evidence indicates that IL-10 plays an important role in both the onset and development of auto-immune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), multiple sclerosis (MS), Crohn's disease (CD), and psoriasis. However, the exact mechanisms of IL-10 in auto-immune diseases remain unclear. In the present review, we will summarize the biological effects of IL-10, as well as its role and therapeutic potential in auto-immune diseases.
authors.affiliation: School of Health Management, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Tian
authors.forename: Jiao-Long
authors.initials: JL
authors.lastname: Li
authors.forename: De-Guang
authors.initials: DG
authors.lastname: Wang
authors.forename: Dian
authors.initials: D
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D016753:Interleukin-10 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D058990:Molecular Targeted Therapy / Q000379:methods*
chemical_list: D016753:Interleukin-10