title: Epidemiology and pathogenesis of Bolivian hemorrhagic fever.
abstract: The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV) is reported to have a mortality rate of 25-35%. First identified in 1959, BHF was the cause of a localized outbreak in San Joaquin until rodent population controls were implemented in 1964. The rodent Calomys collosus was identified as the primary vector and reservoir for the virus. Multiple animal models were considered during the 1970s with the most human-like disease identified in Rhesus macaques but minimal characterization of the pathogenesis has been published since. A reemergence of reported BHF cases has been reported in recent years, which necessitates the further study and development of a vaccine to prevent future outbreaks.
authors.affiliation: Galveston National Laboratory, Department of Pathology, Sealy Vaccine Center, University of Texas Medical Branch, 301 University Blvd, GNL, Galveston, TX 77555-0609, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Patterson
authors.affiliation: Galveston National Laboratory, Department of Pathology, Sealy Vaccine Center, University of Texas Medical Branch, 301 University Blvd, GNL, Galveston, TX 77555-0609, United States.
authors.forename: Ashley
authors.initials: A
authors.lastname: Grant
authors.affiliation: Galveston National Laboratory, Department of Pathology, Sealy Vaccine Center, University of Texas Medical Branch, 301 University Blvd, GNL, Galveston, TX 77555-0609, United States. Electronic address: slpaessl@utmb.edu.
authors.forename: Slobodan
authors.initials: S
authors.lastname: Paessler
mesh_terms: D000818:Animals; D006477:Arenaviruses, New World / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D004195:Disease Models, Animal; D006478:Hemorrhagic Fever, American / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008253:Macaca mulatta; D014774:Virulence