title: Gene variation in IL10 and susceptibility to chronic hepatitis B.
abstract: OBJECTIVE
  To evaluate the correlation between IL-10 gene polymorphisms and hepatitis B infection.
  
  
  METHODS
  Tag single nucleotide polymorphisms (SNPs) were used to investigate the relationship between IL-10 gene polymorphisms and susceptibility to chronic hepatitis B virus (HBV) infection by comparing 996 chronic HBV infection cases to 301 acute infection controls.
  
  
  RESULTS
  This study found that rs3024490 G/T allele, located in the intron 1 region and highly prevalent in Chinese populations, was significantly different between the chronic HBV infection cases and the acute infection controls in single allele analysis, genetic models analysis, and haplotypes analysis.
  
  
  CONCLUSIONS
  This suggested that the rs3024490 within IL-10 was associated with susceptibility to chronic hepatitis B in a Chinese Han population.
authors.affiliation: Department of Communicable Diseases Control, Jiangxi Provincial Center for Disease Control and Prevention, 555 Beijing East Road, Nanchang 330000, Jiangxi, China.
authors.forename: Tian-Chen
authors.initials: TC
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital, Nanchang University, #17 Yongwai Zheng Street, Nanchang 330006, Jiangxi, China.
authors.forename: Wen-Feng
authors.initials: WF
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanchang University, 461 Bayi Road, Nanchang 330006, Jiangxi, China.
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, China.
authors.forename: Fa-Ming
authors.initials: FM
authors.lastname: Pan
authors.affiliation: Department of Infectious Diseases, The Second Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui, China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Gao
authors.affiliation: Department of Communicable Diseases Control, Jiangxi Provincial Center for Disease Control and Prevention, 555 Beijing East Road, Nanchang 330000, Jiangxi, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Communicable Diseases Control, Jiangxi Provincial Center for Disease Control and Prevention, 555 Beijing East Road, Nanchang 330000, Jiangxi, China.
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Liu
authors.affiliation: Jiangxi Provincial Cancer Hospital, 519 Beijing East Road, Nanchang 330029, Jiangxi, China. Electronic address: jorangezhang@sina.com.
authors.forename: Xiao-Dan
authors.initials: XD
authors.lastname: Chen
authors.affiliation: Jiangxi Provincial Cancer Hospital, 519 Beijing East Road, Nanchang 330029, Jiangxi, China.
authors.forename: Cai-Wen
authors.initials: CW
authors.lastname: Zeng
authors.affiliation: Jiangxi Provincial Cancer Hospital, 519 Beijing East Road, Nanchang 330029, Jiangxi, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Liu
authors.affiliation: Jiangxi Provincial Cancer Hospital, 519 Beijing East Road, Nanchang 330029, Jiangxi, China.
authors.forename: Yue-Qing
authors.initials: YQ
authors.lastname: Chen
mesh_terms: D000328:Adult; D044466:Asian People; D020022:Genetic Predisposition to Disease; D019694:Hepatitis B, Chronic / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D016753:Interleukin-10
keywords: Hepatitis B virus; IL-10 gene; Polymorphism