title: Formin' actin in the nucleus.
abstract: Many if not most proteins can, under certain conditions, change cellular compartments, such as, for example, shuttling from the cytoplasm to the nucleus. Thus, many proteins may exert functions in various and very different subcellular locations, depending on the signaling context. A large amount of actin regulatory proteins has been detected in the mammalian cell nucleus, although their potential roles are much debated and are just beginning to emerge. Recently, members of the formin family of actin nucleators were also reported to dynamically localize to the nuclear environment. Here we discuss our findings that specific diaphanous-related formins can promote nuclear actin assembly in a signal-dependent manner.
authors.affiliation: Institute of Pharmacology, Biochemical-Pharmacological Center (BPC) Marburg; University of Marburg; Marburg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Baarlink
authors.affiliation: Institute of Pharmacology, Biochemical-Pharmacological Center (BPC) Marburg; University of Marburg; Marburg, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Grosse
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D003593:Cytoplasm / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins / Q000235:genetics / Q000378:metabolism; D009252:NADPH Dehydrogenase / Q000235:genetics / Q000378:metabolism; D041681:NIH 3T3 Cells; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D026362:Serum Response Factor / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000199:Actins; C569027:Mal protein, mouse; D008840:Microfilament Proteins; D008869:Microtubule-Associated Proteins; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins; D009687:Nuclear Proteins; D026362:Serum Response Factor; C508552:Dia2 protein, mouse; D009252:NADPH Dehydrogenase
keywords: actin dynamics; cytoskeleton; formins; nuclear actin; nuclear mDia