title: Loop de loop: viral RNA evades IFIT1 targeting.
abstract: In a landmark finding published in Science, Hyde et al. have demonstrated that a hairpin RNA structure adjacent to the 5' cap of alphavirus genomic RNA confers the ability of these viruses to evade restriction by the interferon-induced host protein IFIT1.
authors.affiliation: Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Luca, Brisbane, Queensland 4072, Australia.
authors.forename: Justin A
authors.initials: JA
authors.lastname: Roby
authors.affiliation: Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Luca, Brisbane, Queensland 4072, Australia.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Clarke
authors.affiliation: Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Luca, Brisbane, Queensland 4072, Australia. Electronic address: a.khromykh@uq.edu.au.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Khromykh
mesh_terms: D000524:Alphavirus / Q000472:pathogenicity*; D018354:Alphavirus Infections / Q000276:immunology*; D000818:Animals; D054884:Host-Pathogen Interactions / Q000276:immunology*; D012315:RNA Caps / Q000737:chemistry* / Q000276:immunology*; D012367:RNA, Viral / Q000737:chemistry* / Q000276:immunology*
chemical_list: D012315:RNA Caps; D012367:RNA, Viral