title: Cardiovascular biomarkers in patients with psoriasis.
abstract: Psoriasis is a systemic inflammatory disease of the skin with associated comorbidity. Severe forms of psoriasis are associated with increased mortality, which might be due to cardiovascular (CV) comorbidity. In this study, we investigated in 79 patients with psoriasis compared to 80 healthy volunteers different biomarkers that play a role in vascular disease and inflammation, such as C-reactive protein (CRP), human soluble CD40 ligand (sCD40L), oxidized low-density lipoprotein (ox-LDL), human matrix Gla protein (MGP) and fetuin-A. Our results showed that CRP (P < 0.0001), sCD40L (P < 0.0001) and MGP (P < 0.0001) were increased in the patient cohort. Fetuin-A showed decreased serum levels in patients with psoriasis (P < 0.0001), whereas ox-LDL did not show any significant difference. In multivariate analyses controlling for sex, age and BMI, these findings were confirmed. Thus, CV biomarkers are altered in patients with psoriasis. If the decrease in fetuin-A as well as the increase in sCD40L can be proven in further studies, these biomarkers may help to characterize a subgroup of patients who are at risk to develop CVD and/or monitor the effect of therapeutic antipsoriatic strategies on concomitant diseases. This knowledge may be useful in the management of high-need patients with psoriasis.
authors.affiliation: Psoriasis-Center at the Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
authors.forename: Sascha
authors.initials: S
authors.lastname: Gerdes
authors.forename: Swetlana
authors.initials: S
authors.lastname: Osadtschy
authors.forename: Norbert
authors.initials: N
authors.lastname: Buhles
authors.forename: Hansjoerg
authors.initials: H
authors.lastname: Baurecht
authors.forename: Ulrich
authors.initials: U
authors.lastname: Mrowietz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D023201:CD40 Ligand / Q000097:blood*; D002135:Calcium-Binding Proteins / Q000097:blood; D002318:Cardiovascular Diseases / Q000150:complications* / Q000175:diagnosis*; D002319:Cardiovascular System / Q000378:metabolism; D015331:Cohort Studies; D016326:Extracellular Matrix Proteins / Q000097:blood; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007249:Inflammation; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications* / Q000175:diagnosis*; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism; D000097568:Matrix Gla Protein
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D023201:CD40 Ligand; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D008077:Lipoproteins, LDL; D060749:alpha-2-HS-Glycoprotein; D000097568:Matrix Gla Protein; C099252:oxidized low density lipoprotein
keywords: MGP; cardiovascular disease; fetuin-A; psoriasis; sCD40L