title: [Clinical and genetic characteristics of long-livers in Moscow region].
abstract: In Moscow region long-livers we have studied distribution of LPL, CETP, APOE, F2, F5, F7, F13, FGB, ITGA2, ITGB3, PAI-1, MTHFR, MTRR, HLA-DRB1, HLA-DQA1, HLA-DQB1 genes polymorphisms, associated with predisposition to age pathology. Long-livers are characterized by favorable course of cardiovascular diseases accompanied by certain genetic factors. We have established that genotype H-H- of LPL, allele epsilon2 of APOE, genotype CC of MTHFR (677C > T), genotype TC of ITGB3, genotype GA of FGB, HLA-DRB1*11 positively correlate with longevity.
authors.forename: O V
authors.initials: OV
authors.lastname: Artem'eva
authors.forename: I V
authors.initials: IV
authors.lastname: Kostomarova
authors.forename: L D
authors.initials: LD
authors.lastname: Serova
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D009031:Moscow / Q000453:epidemiology; D011110:Polymorphism, Genetic; D015995:Prevalence; D014505:Urban Population
chemical_list: D005819:Genetic Markers