title: Experimental evaluation of the effect of a modified port-location mode on the performance of a three-zone simulated moving-bed process for the separation of valine and isoleucine.
abstract: The removal of isoleucine from valine has been a key issue in the stage of valine crystallization, which is the final step in the valine production process in industry. To address this issue, a three-zone simulated moving-bed (SMB) process for the separation of valine and isoleucine has been developed previously. However, the previous process, which was based on a classical port-location mode, had some limitations in throughput and valine product concentration. In this study, a three-zone SMB process based on a modified port-location mode was applied to the separation of valine and isoleucine for the purpose of making a marked improvement in throughput and valine product concentration. Computer simulations and a lab-scale process experiment showed that the modified three-zone SMB for valine separation led to >65% higher throughput and >160% higher valine concentration compared to the previous three-zone SMB for the same separation.
authors.affiliation: Department of Chemical Engineering, Hanyang University, Seoul, Korea.
authors.forename: Chanhun
authors.initials: C
authors.lastname: Park
authors.forename: Hee-Geun
authors.initials: HG
authors.lastname: Nam
authors.forename: Pung-Ho
authors.initials: PH
authors.lastname: Kim
authors.forename: Sungyong
authors.initials: S
authors.lastname: Mun
mesh_terms: D000327:Adsorption; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D003198:Computer Simulation; D007532:Isoleucine / Q000302:isolation & purification*; D014633:Valine / Q000302:isolation & purification*
chemical_list: D007532:Isoleucine; D014633:Valine
keywords: Continuous separation; Process optimization; Simulated moving bed; Valine