title: The protective effect of ClinOleic against post-surgical adhesions.
abstract: BACKGROUND
  Although the English-language literature is full of studies about post-surgical adhesions, no definitive method has yet been identified to prevent them. The goal of this study was to investigate the effect of ClinOleic on reducing post-surgical adhesion formation.
  
  
  METHODS
  Surgery was performed on 40 adult female Sprague-Dawley rats that were randomly assigned to receive either intraperitoneal ClinOleic, which was used to mimic chyle (ClinOleic group), soybean oil (soybean oil group), olive oil (olive oil group), or 0.9% NaCl suspension (control group). All rats underwent laparotomy, side-wall and cecal abrasion, and primary closure. On the 30th day following surgery, rats were sacrificed and examined using the Majuzi adhesion classification and histopathological grading scales.
  
  
  RESULTS
  The adhesion and histopathological scores of the ClinOleic group were significantly lower compared to the control group (0.9% NaCl) (p<0.05). A statistically significant decrease in fibrosis was observed in the soybean and olive oil groups when compared to the control group (p<0.05). However, the adhesion grades of the ClinOleic, soybean and olive oil groups were comparable. We did not observe any post-surgical adhesions in the ClinOleic group.
  
  
  CONCLUSIONS
  The parenteral nutrition solution ClinOleic may be an effective and readily available agent for the prevention of post-surgical adhesions.
authors.affiliation: Department of General Surgery, Uludağ University Faculty of Medicine, Bursa, Turkey. dryukselaltinel@gmail.com.
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Altınel
authors.affiliation: Department of General Surgery, Uludağ University Faculty of Medicine, Bursa, Turkey.
authors.forename: Ersoy
authors.initials: E
authors.lastname: Taşpınar
authors.affiliation: Department of General Surgery, Uludağ University Faculty of Medicine, Bursa, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Ozgüç
authors.affiliation: Department of General Surgery, Uludağ University Faculty of Medicine, Bursa, Turkey.
authors.forename: Ersin
authors.initials: E
authors.lastname: Oztürk
authors.affiliation: Department of Pathology, Uludağ University Faculty of Medicine, Bursa, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Ulker Akyıldız
authors.affiliation: Uludağ University Faculty of Medicine, Experimental Animals Breeding and Research Center, Bursa, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Bağdaş
mesh_terms: D000818:Animals; D013505:Digestive System Surgical Procedures / Q000009:adverse effects / Q000379:methods*; D005260:Female; D007813:Laparotomy / Q000009:adverse effects / Q000379:methods*; D000069463:Olive Oil; D010537:Peritoneum / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D010938:Plant Oils / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013024:Soybean Oil / Q000494:pharmacology*; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: C568346:ClinOleic; D000069463:Olive Oil; D010938:Plant Oils; D020011:Protective Agents; D013024:Soybean Oil