title: Associations of single nucleotide polymorphisms with malignant and borderline bone tumors.
abstract: Bone neoplasms - are a rare group of diseases, which ethiology and pathogenesis are not fully understood. We have studied 6 single nucleotide polymorphisms rs792/(GHI), rs7956547(IGFI), rs3761243(GNRH2), rs11737764(FGF2), rs6599400(FGFR3), and rs1690916(MDM2) associations with bone tumors. In our work we've detected significant associations with some single nucleotide polymorphisms: IGFl.rs7956547, GNRH2.rs3761243 and FGFR3.rs6599400 in patients with malignant and borderline bone tumors.
authors.forename: N E
authors.initials: NE
authors.lastname: Kushlinskii
authors.forename: Yu S
authors.initials: YS
authors.lastname: Tivofeev
authors.forename: E V
authors.initials: EV
authors.lastname: Generozov
authors.forename: V A
authors.initials: VA
authors.lastname: Naumov
authors.forename: Yu N
authors.initials: YN
authors.lastname: Soloviev
authors.forename: I V
authors.initials: IV
authors.lastname: Boulytcheva
authors.forename: M D
authors.initials: MD
authors.lastname: Aliev
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D007987:Gonadotropin-Releasing Hormone / Q000235:genetics; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D008297:Male; D008875:Middle Aged; D018213:Neoplasms, Bone Tissue / Q000175:diagnosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics
chemical_list: C583557:IGF1 protein, human; D007987:Gonadotropin-Releasing Hormone; D007334:Insulin-Like Growth Factor I; C496365:FGFR3 protein, human; D051498:Receptor, Fibroblast Growth Factor, Type 3