title: Obesity and vitamin D deficiency: trends to promote a more proatherogenic cardiometabolic risk profile.
abstract: Vitamin D deficiency is associated with cardiometabolic risk factors (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We studied 50 obese patients (body mass index [BMI]: 43.5 ± 9.2 kg/m(2)) and 36 normal weight participants (BMI: 22.6 ± 1.9 kg/m(2)). The prevalence of vitamin D deficiency (25-hydroxyvitamin D, 25(OH)D < 50 nmol/L) was 88% among obese patients and 31% among nonobese individuals; 25(OH)D levels were lower in the obese group (27.3 ± 13.7 vs 64.6 ± 21.3 nmol/L; P < .001). There was a negative correlation between vitamin D level and anthropometric indicators of obesity: BMI (r = -0.64; P < .001), waist circumference (r = -0.59; P < .001), and body fat percentage (r = -0.64; P < .001) as well as with fasting plasma insulin (r = -0.35; P < .001) and homeostasis model assessment of insulin resistance (r = -0.35; P < .001). In conclusion, we observed a higher prevalence of vitamin D deficiency among obese participants and this was associated with a proatherogenic cardiometabolic risk profile.
authors.affiliation: Medical Faculty in Novi Sad, Clinical Center of Vojvodina, Novi Sad, Serbia edith@sezampro.rs.
authors.forename: Edita
authors.initials: E
authors.lastname: Stokić
authors.affiliation: Faculty of Technical Sciences, University of Novi Sad, Novi Sad, Serbia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Kupusinac
authors.affiliation: Medical Faculty in Novi Sad, Clinical Center of Vojvodina, Novi Sad, Serbia.
authors.forename: Dragana
authors.initials: D
authors.lastname: Tomić-Naglić
authors.affiliation: Medical Faculty in Novi Sad, Clinical Center of Vojvodina, Novi Sad, Serbia.
authors.forename: Branka Kovačev
authors.initials: BK
authors.lastname: Zavišić
authors.affiliation: Medical Faculty in Novi Sad, Clinical Center of Vojvodina, Novi Sad, Serbia.
authors.forename: Milena
authors.initials: M
authors.lastname: Mitrović
authors.affiliation: Medical Faculty in Novi Sad, University of Novi Sad, Novi Sad, Serbia.
authors.forename: Dragana
authors.initials: D
authors.lastname: Smiljenić
authors.affiliation: Laboratory for Molecular Genetics and Radiobiology, Institute of nuclear sciences "Vinca", University of Belgrade, Belgrade, Serbia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Soskić
authors.affiliation: Laboratory for Molecular Genetics and Radiobiology, Institute of nuclear sciences "Vinca", University of Belgrade, Belgrade, Serbia.
authors.forename: Esma
authors.initials: E
authors.lastname: Isenović
mesh_terms: D050154:Adiposity; D000328:Adult; D050197:Atherosclerosis / Q000175:diagnosis / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D055771:Serbia / Q000453:epidemiology; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: cardiometabolic risk; obesity; vitamin D deficiency