title: The role of human papillomavirus in oral disease.
abstract: A wide range of human papillomavirus (HPV) genotypes have been detected in oral mucosa. Clinical infections with low-risk genotypes manifest as squamous papilloma, condyloma acuminatum, verruca vulgaris, or multifocal epithelial hyperplasia. Clinical infections with high-risk genotypes have been associated with malignant lesions. The most common genotype isolated from subclinical infection is HPV-16. A causal role for HPV in carcinogenesis of oral squamous carcinoma is minimal. Ongoing vaccination against HPV types 6, 11, 16, and 18 is expected to decrease the spread of infection and decrease the carcinogenic potential of HPV-16 in the oropharynx and oral cavity.
authors.affiliation: Oral Pathology Laboratory, Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19040, USA. Electronic address: gpringle@temple.edu.
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Pringle
mesh_terms: D052685:Alphapapillomavirus / Q000145:classification / Q000502:physiology*; D063646:Carcinogenesis; D003218:Condylomata Acuminata / Q000821:virology; D017573:Focal Epithelial Hyperplasia / Q000821:virology; D006801:Humans; D009059:Mouth Diseases / Q000821:virology*; D009062:Mouth Neoplasms / Q000821:virology; D010212:Papilloma / Q000821:virology; D030361:Papillomavirus Infections / Q000175:diagnosis*; D053918:Papillomavirus Vaccines; D011230:Precancerous Conditions / Q000821:virology; D014860:Warts / Q000821:virology
chemical_list: D053918:Papillomavirus Vaccines
keywords: Condyloma acuminatum; Human papillomavirus; Multifocal epithelial hyperplasia; Oral squamous cell carcinoma; Squamous papilloma; Verruca vulgaris