title: In vitro microbiological evaluation of novel bis pyrazolones.
abstract: Two series of bis pyrazolones (one with 3-methyl substituent and the other one with 3-amino substituent on the pyrazolone ring) were synthesized by the cyclization reaction between various hydrazides with esters/cyano esters in ethanolic medium. Structures of newly synthesized compounds were confirmed by elemental analysis, IR, (1)H NMR and mass spectral data. These compounds were screened for antibacterial and antifungal activities. The compounds of series 3 with amino substituent demonstrated better activity than the compounds of series 2 with methyl substituent on the pyrazolone ring. Compounds "e, f, c and d" showed higher antimicrobial activity than the compounds "b and a". The antimicrobial potentials of the synthesized compounds were compared with that of standards.
authors.affiliation: Department of Chemistry, Sri Krishnadevaraya University, Anantapur, AP, India.
authors.forename: D V
authors.initials: DV
authors.lastname: Narayana Rao
authors.affiliation: Faculty of Science and Technology, ICFAI Foundation for Higher Education, Hyderabad, AP, India. Electronic address: guruar@rediffmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Raghavendra Guru Prasad
authors.affiliation: Department of Chemistry, Sri Krishnadevaraya University, Anantapur, AP, India.
authors.forename: Y N
authors.initials: YN
authors.lastname: Spoorthy
authors.affiliation: Extension and Training Division, National Institute of Nutrition, Indian Council for Medical Research, Hyderabad, AP, India.
authors.forename: D
authors.initials: D
authors.lastname: Raghunatha Rao
authors.affiliation: Department of Chemistry, Sri Krishnadevaraya University, Anantapur, AP, India.
authors.forename: L K
authors.initials: LK
authors.lastname: Ravindranath
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011720:Pyrazoles
keywords: Activité antibactérienne; Antimicrobial activity; Bis pyrazolones; Caractérisation structurale; Structural characterization; Synthesis; Synthèse