title: New Taxane Diterpenoids from Taxus yunnanensis.
abstract: Three hitherto unknown taxane diterpenoids, namely baccatin VIII (1), baccatin IX (2), and baccatin X (3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analysis. Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines, and 1 exhibited inhibitory effects on HL-60 and MCF-7, with IC50 values of 3.44 and 9.67 μM, respectively.
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201 China.
authors.forename: Ping
authors.initials: P
authors.lastname: Hai
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201 China.
authors.forename: Shi-Zhen
authors.initials: SZ
authors.lastname: Wen
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201 China ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201 China.
authors.forename: Xian-Jun
authors.initials: XJ
authors.lastname: Jiang
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201 China ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
keywords: Baccatin; Cytotoxicity; Taxane; Taxus yunnanensis