title: Successful treatment of erythropoietin-producing advanced renal cell carcinoma after targeted therapy using sunitinib: Case report and review of the literature.
abstract: In general, only ≤5% of patients with renal cell carcinoma (RCC) develop paraneoplastic erythropoietin (EPO) overproduction-induced polycythemia. However, a number of reports on EPO-producing RCC are available. The present study aimed to report the first case of a patient demonstrating a therapeutic effect on EPO-producing advanced RCC, subsequent to targeted pre-surgical sunitinib therapy, with a review of the literature. The patient involved was a 62-year-old male who presented with a malformation of the left scrotum. Examination revealed a tumor of 73 mm in diameter along with lymph node metastasis. The histological examination indicated a clear cell RCC containing viable cells as well as hemorrhage and necrosis. EPO in cancer cells was confirmed by immunohistochemistry. Subsequently, a case of EPO-producing RCC with polycythemia was diagnosed. The EPO-producing RCC was successfully treated following targeted presurgical therapy with sunitinib.
authors.affiliation: Department of Urology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Ueda
authors.affiliation: Department of Urology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Suekane
authors.affiliation: Department of Urology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Chikui
authors.affiliation: Department of Urology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakiri
authors.affiliation: Department of Urology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Fukuko
authors.initials: F
authors.lastname: Moriya
authors.affiliation: Department of Urology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Tokumasa
authors.initials: T
authors.lastname: Hayashi
authors.affiliation: Department of Urology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Jiro
authors.initials: J
authors.lastname: Miyajima
authors.affiliation: Department of Urology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Matsuoka
keywords: erythropoietin; polycythemia; renal cell carcinoma; sunitinib