title: [Febrile episodes of unknown origin, elevated level of plasma ferritin and rapidly developed multiorgan dysfunction].
abstract: A previously healthy 40-year-old man developed febrile episodes of unknown origin, articular symptoms, venous occlusion of the lower limb and transient elevation of hepatic enzymes, and cutaneous symptoms. Computed tomography scanning revealed enlarged lymph nodes, but no sample was collected. In addition to microcytic anemia, a high serum ferritin level and an increased IL-2 receptor value in serum were found. Drug therapy against tuberculosis and borreliosis was started, but febrile episodes continued and in a few days the patient developed multiorgan dysfunction. Hemophagocytic lymphohistiocytosis associated with T-cell lymphoma was revealed as the underlying condition.
authors.forename: Esa
authors.initials: E
authors.lastname: Jantunen
authors.forename: Sanna
authors.initials: S
authors.lastname: Siitonen
authors.forename: Marja-Liisa
authors.initials: ML
authors.lastname: Karjalainen-Lindsberg
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005293:Ferritins / Q000097:blood; D005335:Fever of Unknown Origin; D006801:Humans; D008111:Liver Function Tests; D008209:Lymphedema; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis*; D016399:Lymphoma, T-Cell / Q000175:diagnosis*; D008297:Male; D015375:Receptors, Interleukin-2 / Q000097:blood; D014057:Tomography, X-Ray Computed
chemical_list: D015375:Receptors, Interleukin-2; D005293:Ferritins