title: Role of toll-like receptors in lung cancer.
abstract: Lung cancer is a leading cause of death world-wide and the long-term survival rate for patients with lung cancer is one of the lowest for any cancer. Toll-like receptors (TLRs), evolutionarily conserved innate, are expressed in a wide variety of tissues and cell types, and they play key role in the innate immune system. TLRs have been found to be expressed by some kinds of tumor cells. However, what is the biological function of TLRs on tumor cells and whether human lung cancer cells can express TLRs remain to be fully understood. This review was performed to sum up the role of TLRs in lung cancer.
authors.affiliation: Department of Cardio-Thoracic Surgery, The Affiliated Ruikang Hospital of Guangxi University of traditional Chinese Medicine , NanNing , China.
authors.forename: Liu-Shan
authors.initials: LS
authors.lastname: Yang
authors.forename: Wen-Sen
authors.initials: WS
authors.lastname: Wu
authors.forename: Fu
authors.initials: F
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yue
authors.initials: Y
authors.lastname: Fan
authors.forename: Heng-Xiao
authors.initials: HX
authors.lastname: Fang
authors.forename: Ju
authors.initials: J
authors.lastname: Long
mesh_terms: D045744:Cell Line, Tumor; D016207:Cytokines / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism*
chemical_list: D016207:Cytokines; D051193:Toll-Like Receptors
keywords: Toll-like receptors; lung cancer; signaling pathways