title: Synthetic approaches to the 2012 new drugs.
abstract: New drugs introduced to the market every year represent a privileged structure for a particular biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the synthesis of twenty-six NCEs that were launched or approved worldwide in 2012 and two additional drugs which were launched at the end of 2011.
authors.affiliation: PharmaPhase Co., Ltd, Beijing 100193, China. Electronic address: Hongxia.ding@gmail.com.
authors.forename: Hong X
authors.initials: HX
authors.lastname: Ding
authors.affiliation: Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: carolyn.a.leverett@pfizer.com.
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Leverett
authors.affiliation: Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: robert.kynejr@pfizer.com.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Kyne
authors.affiliation: Lilly China Research and Development Center, Shanghai 201203, China. Electronic address: Liu_kang_zhi_kevin@lilly.com.
authors.forename: Kevin K-C
authors.initials: KK
authors.lastname: Liu
authors.affiliation: BioDuro Co., Ltd, Shanghai 200131, China. Electronic address: subas.sakya@bioduro.com.
authors.forename: Subas M
authors.initials: SM
authors.lastname: Sakya
authors.affiliation: Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: andrew.flick@pfizer.com.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Flick
authors.affiliation: Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: christopher.j.odonnell@pfizer.com.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: O'Donnell
mesh_terms: D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations
keywords: Medicine; New chemical entities; New drug molecules; Synthesis; Therapeutic agents