title: Autologous bone marrow mononuclear cells in ischemic cerebrovascular accident paves way for neurorestoration: a case report.
abstract: In response to acute ischemic stroke, large numbers of bone marrow stem cells mobilize spontaneously in peripheral blood that home onto the site of ischemia activating the penumbra. But with chronicity, the numbers of mobilized cells decrease, reducing the degree and rate of recovery. Cellular therapy has been explored as a new avenue to restore the repair process in the chronic stage. A 67-year-old Indian male with a chronic right middle cerebral artery ischemic stroke had residual left hemiparesis despite standard management. Recovery was slow and partial resulting in dependence to carry out activities of daily living. Our aim was to enhance the speed of recovery process by providing an increased number of stem cells to the site of injury. We administered autologous bone marrow mononuclear cells intrathecally alongwith rehabilitation and regular follow up. The striking fact was that the hand functions, which are the most challenging deficits, showed significant recovery. Functional Independence Measure scores and quality of life improved. This could be attributed to the neural tissue restoration. We hypothesize that cell therapy may be safe, novel and appealing treatment for chronic ischemic stroke. Further controlled trials are indicated to advance the concept of Neurorestoration.
authors.affiliation: Department of Medical Services and Clinical Research, Neurogen, Brain and Spine Institute Private Limited, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion Trombay Road, Chembur, Mumbai, Maharashtra 400071, India.
authors.forename: Alok
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Department of Research and Development, Neurogen, Brain and Spine Institute Private Limited, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion Trombay Road, Chembur, Mumbai, Maharashtra 400071, India.
authors.forename: Hemangi
authors.initials: H
authors.lastname: Sane
authors.affiliation: Department of Neuro-Rehabilitation, Neurogen, Brain and Spine Institute Private Limited, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion Trombay Road, Chembur, Mumbai, Maharashtra 400071, India.
authors.forename: Anjana
authors.initials: A
authors.lastname: Nagrajan
authors.affiliation: Department of Medical Services and Clinical Research, Neurogen, Brain and Spine Institute Private Limited, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion Trombay Road, Chembur, Mumbai, Maharashtra 400071, India.
authors.forename: Nandini
authors.initials: N
authors.lastname: Gokulchandran
authors.affiliation: Department of Medical Services and Clinical Research, Neurogen, Brain and Spine Institute Private Limited, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion Trombay Road, Chembur, Mumbai, Maharashtra 400071, India.
authors.forename: Prerna
authors.initials: P
authors.lastname: Badhe
authors.affiliation: Department of Neuro-Rehabilitation, Neurogen, Brain and Spine Institute Private Limited, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion Trombay Road, Chembur, Mumbai, Maharashtra 400071, India.
authors.forename: Amruta
authors.initials: A
authors.lastname: Paranjape
authors.affiliation: Department of Neuro-Rehabilitation, Neurogen, Brain and Spine Institute Private Limited, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion Trombay Road, Chembur, Mumbai, Maharashtra 400071, India.
authors.forename: Hema
authors.initials: H
authors.lastname: Biju