title: GABABreceptors in the bladder and bowel: therapeutic potential for positive allosteric modulators?: Commentary on Kalinichev et al., Br J Pharmacol 171: 995-1006.
abstract: This article is a Commentary on Kalinichev M, Palea S, Haddouk H, Royer-Urios I, Guilloteau V, Lluel P, Schneider M, Saporito M and Poli S (2014). ADX71441, a novel, potent and selective positive allosteric modulator of the GABAB receptor, shows efficacy in rodent models of overactive bladder. Br J Pharmacol 171: 995-1006. doi: 10.1111/bph.12517.
authors.affiliation: Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.|Department of Pharmacology & Therapeutics, University College Cork, Cork, Ireland.
authors.forename: Niall P
authors.initials: NP
authors.lastname: Hyland
authors.affiliation: Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.
authors.forename: Anna V
authors.initials: AV
authors.lastname: Golubeva
keywords: GABAB receptor; bladder pain syndrome; colon; gastrointestinal; irritable bowel syndrome; motility; positive allosteric modulator; visceral hypersensitivity