title: Association ofultraviolet radiation resistance-associatedgene polymorphisms with rheumatoid arthritis.
abstract: The ultraviolet radiation resistance-associated gene (UVRAG) protein binds to the Beclin 1/PI3-kinase III complex and promotes autophagy. Autophagy may be upregulated by endoplasmic reticulum (ER) stress. Persistent and excessive ER stress may alter synovial fibroblast apoptosis and this alteration may affect the pathogenesis of rheumatoid arthritis (RA). In this study, we investigated whetherUVRAGgenetic polymorphisms are associated with RA. To determine the association betweenUVRAGpolymorphisms and RA, we genotyped fiveUVRAGsingle-nucleotide polymorphisms (SNPs; rs7111334, intron C/T; rs7933235, intron A/G; rs1380075, intron T/A; rs1458836, near the 5' gene terminal G/A; and rs636420, exon 15 C/T) using a direct sequencing method in 243 RA patients and 417 control subjects. Among these, one SNP (rs7111334) exhibited significant genotypic/allelic differences between RA patients and the control group. Therefore, this study suggested a possible association betweenUVRAGpolymorphisms and RA susceptibility.
authors.affiliation: Department of Clinical Pharmacology, Soonchunhyang University, Cheonan, Republic of Korea.
authors.forename: Hyung-Ki
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Soonchunhyang Medical Research Institute, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.
authors.forename: Wha-Young
authors.initials: WY
authors.lastname: Lee
authors.affiliation: Department of Clinical Pharmacology, Soonchunhyang University, Cheonan, Republic of Korea.
authors.forename: Jun-Tack
authors.initials: JT
authors.lastname: Kwon
authors.affiliation: Department of Clinical Pharmacology, Soonchunhyang University, Cheonan, Republic of Korea.
authors.forename: Dong-Ryul
authors.initials: DR
authors.lastname: Sohn
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Hong
authors.affiliation: Department of Clinical Pharmacology, Soonchunhyang University, Cheonan, Republic of Korea ; Soonchunhyang Medical Research Institute, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.
authors.forename: Hak-Jae
authors.initials: HJ
authors.lastname: Kim
keywords: association; rheumatoid arthritis; single-nucleotide polymorphism; ultraviolet radiation resistance-associated gene