title: [Association between SNPs in DNMT1 and noise-induced hearing loss in Chinese Han population].
abstract: OBJECTIVE
  To investigate the association between single nucleotide polymorphisms (SNPs) in DNA methyltransferase 1 (DNMT1) (rs12984523, rs16999593, and rs2228612) and noise-induced hearing loss (NIHL) in Chinese Han population.
  
  
  METHODS
  This case-control study consisted of 188 cases (case group) and 300 controls (control group) in the same working position, who were matched for age and gender. The cases had a binaural average high-frequency hearing threshold not less than 40 dB, and the controls had a binaural average high-frequency hearing threshold less than 40 dB. The genotypes at the three SNPs were determined by TaqMan probe.
  
  
  RESULTS
  TT genotype at DNMT1 rs2228612 is a risk factor for NIHL (adjusted OR = 1.69, 95% CI: 1.14-2.52).
  
  
  CONCLUSIONS
  The study of Chinese Han population suggested that DNMT1 rs2228612 is associated with susceptibility to NIHL.
authors.affiliation: Changzhou Center for Disease Control and Prevention, Changzhou, Jiangsu 213022, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Hu
authors.forename: Hengdong
authors.initials: H
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Bian
authors.affiliation: E-mail: zhubl@jscdc.cn.
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhu
authors.affiliation: E-mail: zdzhang2005@gmail.com.
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001309:Auditory Threshold; D016022:Case-Control Studies; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006317:Hearing Loss, Noise-Induced / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009623:Noise, Occupational; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases; C000619380:DNMT1 protein, human