title: Youngest reported patient presenting with an androgen producing sclerosing stromal ovarian tumor.
abstract: BACKGROUND
  Sclerosing stromal tumors are extremely rare sex cord stromal tumors of the ovary, with approximately 100 cases reported since first described in 1973. These tumors present predominantly in the 2nd and 3rd decades of life, typically present with pelvic/abdominal pain and tenderness, mass, and/or abnormal menses, and with hormonal activity reported predominantly in postmenarchal females. Only 5 cases of these tumors have been reported in premenarchal girls, with age ranging from 7 months to 12 years. Only 2 demonstrated hormonal manifestations, with vaginal bleeding due to hyperestrogenism in the 7 month old, and virilization in an 11-year-old female.
  
  
  METHODS
  We report a 9-year-old female who was diagnosed with this ovarian tumor, and who presented with virilization.
  
  
  CONCLUSIONS
  This report is remarkable as our patient not only was diagnosed with an ovarian tumor that is extremely rare in this age group but is the youngest reported patient with this tumor who presented with virilization.
authors.affiliation: Department of Pediatrics, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Yen
authors.affiliation: Department of Pathology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
authors.forename: Malik
authors.initials: M
authors.lastname: Deen
authors.affiliation: Department of Pediatrics, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA. Electronic address: marshaia@rwjms.rutgers.edu.
authors.forename: Ian
authors.initials: I
authors.lastname: Marshall
mesh_terms: D000367:Age Factors; D002648:Child; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D018312:Sex Cord-Gonadal Stromal Tumors / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D045165:Testosterone Congeners / Q000378:metabolism*; D014770:Virilism / Q000209:etiology*
chemical_list: D045165:Testosterone Congeners
keywords: Androgens; Ovarian tumor; Puberty; Sclerosing stromal tumor; Virilization