title: Effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To assess the efficacy and safety of treating pregnant women with gestational diabetes mellitus in comparison to usual antenatal care.
  
  
  METHODS
  A systematic review and meta-analysis was conducted by including randomized controlled trials comparing any form of therapeutic intervention in comparison to usual antenatal care. A literature search was conducted using electronic databases together with a hand search of relevant journals and conference proceedings.
  
  
  RESULTS
  Ten studies involving 3,881 patients contributed to meta-analysis. Our results indicated that gestational diabetes mellitus treatment significantly reduced the risk for macrosomia (RR, 0.47; 95% CI, 0.38-0.57), large for gestational age births (RR, 0.55; 95% CI, 0.45-0.67), shoulder dystocia (RR, 0.42; 95% CI, 0.23-0.77) and gestational hypertension (RR, 0.68; 95% CI, 0.53-0.87) without causing any significant increase in the risk for small for gestational age babies. However, no significant difference was observed between the two groups regarding perinatal/neonatal mortality, neonatal hypoglycemia, birth trauma, preterm births, pre-eclampsia, caesarean section and labor induction.
  
  
  CONCLUSIONS
  Treating GDM reduces risk for many important adverse pregnancy outcomes and its association with any harm seems unlikely.
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon-Pathom, Thailand.
authors.forename: Nalinee
authors.initials: N
authors.lastname: Poolsup
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
authors.forename: Naeti
authors.initials: N
authors.lastname: Suksomboon
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Amin
mesh_terms: D000328:Adult; D015982:Bias; D001786:Blood Glucose / Q000378:metabolism; D016640:Diabetes, Gestational / Q000628:therapy*; D005260:Female; D005320:Fetal Macrosomia / Q000517:prevention & control; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000209:etiology / Q000517:prevention & control; D011225:Pre-Eclampsia / Q000517:prevention & control; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D001786:Blood Glucose