title: Relationship between serum cystatin C and polycystic ovary syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) causes an increased risk of metabolic cardiovascular syndrome. Also, cystatin C serum levels are associated with the risk of cardiovascular events in metabolic syndrome patients.
  
  
  OBJECTIVE
  To investigate the relationship between cystatin C in PCOS patients.
  
  
  METHODS
  35 women with PCOS were compared to 35 women with healthy matched age and body mass index. They all underwent tests to determine plasma levels of C-reactive protein (CRP), cystatin C, lipid profile and apo-lipoprotein. Blood pressure and demographic variables of each subject were obtained.
  
  
  RESULTS
  Systolic and diastolic blood pressure were higher in PCOS patients compared to control group. Triglyceride and low-density lipoprotein cholesterol levels were higher in PCOS; contrariwise, high-density lipoprotein was lower from that of healthy volunteers. Cystatin and CRP levels were significantly higher in patients with PCOS in comparison with healthy subjects (p<0.0001). Among measured determinants, only PCOS status was independently associated with cystatin C.
  
  
  CONCLUSIONS
  Cystatin C was positively correlated with PCOS status concentrations but not with systolic and diastolic blood pressure, or any of the lipid profile variables or demographic characteristics. Indeed, no correlation was found between cystatin C and CRP levels. Therefore, cystatin C might be related to PCOS beyond its use as a marker of the renal function.
authors.affiliation: Department of Endocrinology, Metabolism and Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Gozashti
authors.affiliation: Department of Biochemistry, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Gholamhosseinian
authors.affiliation: Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Musavi
authors.affiliation: Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Mashrouteh
keywords: Blood pressure; C-reactive protein; Cystatin C; Dyslipidemia; Polycystic ovary syndrome