title: All-trans-retinoic acid promotes iodine uptake via up- regulating the sodium iodide symporter in medullary thyroid cancer stem cells.
abstract: Recently, the main therapy of medullary thyroid cancer (MTC) is surgical, but by which way there is a poor prognosis with a mean survival of only 5 years. In some cases, some researchers found that it is the medullary thyroid cancer stem cells (MTCSCs) that cause metastasis and recurrence. This study aimed to eradicate MTCSCs through administration of all-trans-retinoic acid (ATRA). Here we demonstrate that MTCSCs possess stem- like properties in serum-free medium. The ABCG2, OCT4 and sodium iodide symporter (NIS) were changed by ATRA. Additionally, we found that ATRA can increase the expression of NIS in vivo. All the data suggested that ATRA could increase the iodine uptake of MTCSCs through NIS.
authors.affiliation: Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China E-mail : pengzhiping@cqmu.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Tang
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Hou
authors.forename: Qiang-Qiang
authors.initials: QQ
authors.lastname: Kang
authors.forename: Xing-Yue
authors.initials: XY
authors.lastname: Chen
authors.forename: Li-Qun
authors.initials: LQ
authors.lastname: Duan
authors.forename: Jin
authors.initials: J
authors.lastname: Shu
authors.forename: Shao-Lin
authors.initials: SL
authors.lastname: Li
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Hu
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Peng
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D018278:Carcinoma, Neuroendocrine; D006801:Humans; D007455:Iodine / Q000378:metabolism*; D007457:Iodine Radioisotopes / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D009363:Neoplasm Proteins / Q000235:genetics; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology*; D050814:Octamer Transcription Factor-3 / Q000235:genetics; D018874:Spheroids, Cellular; D027981:Symporters / Q000235:genetics*; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology*; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D000099209:Sodium-Iodide Symporters
chemical_list: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D000970:Antineoplastic Agents; D007455:Iodine; D007457:Iodine Radioisotopes; D009363:Neoplasm Proteins; D050814:Octamer Transcription Factor-3; D027981:Symporters; D014212:Tretinoin; D000099209:Sodium-Iodide Symporters; C116614:ABCG2 protein, human; C494173:POU5F1 protein, human