title: A magnetic nanogel based on O-carboxymethylchitosan for antitumor drug delivery: synthesis, characterization and in vitro drug release.
abstract: This paper studied the synthesis, characterization and use of the magnetic chitosan nanogel for carrying meleimidic compounds. The hydrogel polymer was prepared using O-carboxymethylchitosan, which was crosslinked with epichlorohydrin for subsequent incorporation of iron oxide magnetic nanoparticles. The characterization revealed that the magnetic material comprises about 10% of the hydrogel. This material is comprised of magnetite and maghemite and exhibits ferro-ferrimagnetic behavior. The average particle size is 4.2 nm. There was high incorporation efficiency of maleimides in the magnetic nanogel. The release was of sustained character and there was a greater release when an external magnetic field was applied. The mathematical model that best explained the process of drug release by the magnetic hydrogel was that of Peppas-Sahlin. The magnetic nanogel proved to be an excellent candidate for use in drug-delivery systems.
authors.affiliation: Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI), Itajaí, 88302-202, Santa Catarina, Brazil. crodrigues@univali.br.
authors.forename: Carla Albetina
authors.initials: CA
authors.lastname: Demarchi
authors.forename: Aline
authors.initials: A
authors.lastname: Debrassi
authors.forename: Fátima de Campos
authors.initials: Fde C
authors.lastname: Buzzi
authors.forename: Rogério
authors.initials: R
authors.lastname: Corrêa
authors.forename: Valdir Cechinel
authors.initials: VC
authors.lastname: Filho
authors.forename: Clovis Antonio
authors.initials: CA
authors.lastname: Rodrigues
authors.forename: Nataliya
authors.initials: N
authors.lastname: Nedelko
authors.forename: Pavlo
authors.initials: P
authors.lastname: Demchenko
authors.forename: Anna
authors.initials: A
authors.lastname: Ślawska-Waniewska
authors.forename: Piotr
authors.initials: P
authors.lastname: Dłużewski
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Greneche
mesh_terms: D000327:Adsorption; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism; D002152:Calorimetry, Differential Scanning; D002417:Cattle; D048271:Chitosan / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D065546:Drug Liberation; D004811:Epichlorohydrin / Q000737:chemistry; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry; D000080385:Nanogels; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D015204:Spectroscopy, Mossbauer; D013818:Thermogravimetry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D000080385:Nanogels; C504164:O-carboxymethylchitosan; C413692:polyethylene glycol polyethyleneimine nanogel; D004811:Epichlorohydrin; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D011094:Polyethyleneimine; D048271:Chitosan