title: Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies.
abstract: Chronic-inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disease with no known biomarkers for diagnosing the disease or assessing its prognosis. We performed transcriptional profiling microarray analysis on skin punch biopsies from 20 CIDP patients and 17 healthy controls to identify disease-associated gene expression changes. We demonstrate changes in expression of genes involved in immune and chemokine regulation, growth and repair. We also found a combination of two upregulated genes that can be proposed as a novel biomarker of the disorder.
authors.affiliation: Department of Clinical Neurosciences, Nerve-Muscle Unit, Lausanne University Hospital (CHUV), rue du Bugnon 46, CH-1011 Lausanne, Switzerland; Institute of Biotechnology, University of Lausanne (UNIL), chemin des Alambiques, CH-1015 Lausanne, Switzerland.
authors.forename: Stefania
authors.initials: S
authors.lastname: Puttini
authors.affiliation: Department of Clinical Neurosciences, Nerve-Muscle Unit, Lausanne University Hospital (CHUV), rue du Bugnon 46, CH-1011 Lausanne, Switzerland.
authors.forename: Petrica-Adrian
authors.initials: PA
authors.lastname: Panaite
authors.affiliation: Institute of Biotechnology, University of Lausanne (UNIL), chemin des Alambiques, CH-1015 Lausanne, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mermod
authors.affiliation: Department of Clinical Neurosciences, Nerve-Muscle Unit, Lausanne University Hospital (CHUV), rue du Bugnon 46, CH-1011 Lausanne, Switzerland; Neurology Division, Hôpital Neuchâtelois, Maladière 45, CH-2000 Neuchâtel, Switzerland.
authors.forename: Susanne
authors.initials: S
authors.lastname: Renaud
authors.affiliation: Department of Clinical Neurosciences, Nerve-Muscle Unit, Lausanne University Hospital (CHUV), rue du Bugnon 46, CH-1011 Lausanne, Switzerland; Department of Neurology, Basel University Hospital, Spitalstrasse 21, 4031 Basel, Switzerland.
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Steck
authors.affiliation: Department of Clinical Neurosciences, Nerve-Muscle Unit, Lausanne University Hospital (CHUV), rue du Bugnon 46, CH-1011 Lausanne, Switzerland. Electronic address: thierry.kuntzer@chuv.ch.
authors.forename: Thierry
authors.initials: T
authors.lastname: Kuntzer
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D016133:Polymerase Chain Reaction; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000235:genetics*; D012867:Skin; D059467:Transcriptome
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Chronic inflammatory demyelinating polyneuropathy (CIDP); Gene expression analysis; Skin biopsies