title: Lipid-lowering and antioxidant functions of bottle gourd (Lagenaria siceraria) extract in human dyslipidemia.
abstract: The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenaria siceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenaria siceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions (P < .01) were found in triglycerides and total cholesterol levels in blood. Cardiac risk ratio, atherogenic coefficient, and atherogenicity index of plasma were also improved. Appreciable reductions in body mass index (P < .01) and blood pressure (systolic P < .01, diastolic P < .05) along with a significant reduction (P < .05) in fasting blood glucose levels were also observed in these subjects. Lagenaria siceraria fruit extract exhibited significant antioxidant activity in dyslipidemic subjects as evident from elevations in SOD (P < .05) and GSH levels (P < .01) with marked improvement in catalase (P < .01) and TBARS levels (P < .05). Phytochemical screening confirmed the presence of saponins, glycosides, flavonoids, terpenoids, and phenolic compounds. Lagenaria siceraria fruit extract serves as dietary adjunct in treatment of human dyslipidemia and cardiovascular disease.
authors.affiliation: Department of Food & Nutrition, Kamla Raja Girls (PG), Autonomous College, Gwalior, Madhya Pradesh, India.
authors.forename: Charu
authors.initials: C
authors.lastname: Katare
authors.forename: Sonali
authors.initials: S
authors.lastname: Saxena
authors.forename: Supriya
authors.initials: S
authors.lastname: Agrawal
authors.forename: Anish Zacharia
authors.initials: AZ
authors.lastname: Joseph
authors.forename: Senthil Kumar
authors.initials: SK
authors.lastname: Subramani
authors.forename: Dhananjay
authors.initials: D
authors.lastname: Yadav
authors.forename: Nita
authors.initials: N
authors.lastname: Singh
authors.forename: Prakash Singh
authors.initials: PS
authors.lastname: Bisen
authors.forename: G B K S
authors.initials: GB
authors.lastname: Prasad
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D016022:Case-Control Studies; D019662:Cucurbitaceae / Q000737:chemistry*; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D012639:Seeds / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts
keywords: Lagenaria siceraria; atherosclerosis; dyslipidemia; hyperglycemia; oxidative stress