title: Hyperhomocysteinemia is a risk factor for Alzheimer's disease in an Algerian population.
abstract: OBJECTIVE
  There is growing evidence that increased blood concentration of total homocysteine (tHcy) may be a risk factor for Alzheimer's disease (AD). The present study was conducted to evaluate the association of serum tHcy and other biochemical risk factors with AD.
  
  
  METHODS
  This is a case-control study including 41 individuals diagnosed with AD and 46 nondemented controls. Serum levels of all studied biochemical parameters were performed.
  
  
  RESULTS
  Univariate logistic regression showed a significant increase of tHcy (p = 0.008), urea (p = 0.036) and a significant decrease of vitamin B12 (p = 0.012) in AD group vs. controls. Using multivariate logistic regression, tHcy (p = 0.007, OR = 1.376) appeared as an independent risk factor predictor of AD. There was a significant positive correlation between tHcy and creatinine (p <0.0001). A negative correlation was found between tHcy and vitamin B12 (p <0.0001).
  
  
  CONCLUSIONS
  Our findings support that hyperhomocysteinemia is a risk factor for AD in an Algerian population and is also associated with vitamin B12 deficiency.
authors.affiliation: Département de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene Alger, Algérie.
authors.forename: Khaled
authors.initials: K
authors.lastname: Nazef
authors.affiliation: Département de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene Alger, Algérie. Electronic address: malikakhelil@hotmail.fr.
authors.forename: Malika
authors.initials: M
authors.lastname: Khelil
authors.affiliation: Département de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene Alger, Algérie.
authors.forename: Hiba
authors.initials: H
authors.lastname: Chelouti
authors.affiliation: Laboratoire de Biochimie, Hôpital Central de l'Armée Mohamed Nekkache Alger, Algérie.
authors.forename: Ghouti
authors.initials: G
authors.lastname: Kacimi
authors.affiliation: Service de Neurologie, Hôpital Central de l'Armée Mohamed Nekkache Alger, Algérie.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Bendini
authors.affiliation: Service de Neurologie, Centre Hospitalo-Universitaire (CHU) Mustapha Bacha Alger, Algérie.
authors.forename: Meriem
authors.initials: M
authors.lastname: Tazir
authors.affiliation: Service de Neurologie, Centre Hospitalo-Universitaire (CHU) Mustapha Bacha Alger, Algérie.
authors.forename: Soraya
authors.initials: S
authors.lastname: Belarbi
authors.affiliation: Laboratoire Central de Biologie, Centre Hospitalo-Universitaire (CHU) Nafissa Hamoud Alger, Algérie.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El Hadi Cherifi
authors.affiliation: Département de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene Alger, Algérie.
authors.forename: Bahia
authors.initials: B
authors.lastname: Djerdjouri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000462:Algeria / Q000453:epidemiology; D000544:Alzheimer Disease / Q000097:blood / Q000208:ethnology / Q000209:etiology*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications* / Q000208:ethnology; D016015:Logistic Models; D008297:Male; D012307:Risk Factors; D013972:Thyrotropin / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000150:complications / Q000208:ethnology; D014803:Vitamin B Complex / Q000097:blood
chemical_list: D006710:Homocysteine; D014803:Vitamin B Complex; D014527:Uric Acid; D013972:Thyrotropin; D005492:Folic Acid; D002784:Cholesterol; D014805:Vitamin B 12
keywords: Alzheimer's disease; Folate; Hyperhomocysteinemia; Vitamin B12