title: Does intravenous saline infusion compromise the stability of [123I] meta-iodobenzylguanidine?
abstract: To avoid adverse effects during the administration of [(123)I] meta-iodobenzylguanidine (MIBG), infusion of the drug that has been previously diluted is proposed. Stability of [(123)I] MIBG in sodium chloride solutions is studied, looking for incompatibilities in the formulation. Stability was tested on the basis of the percentage of free [(123)I] iodide on solid-phase extraction. No increase in percentages of free [(123)I] iodide was found in diluted and undiluted samples over time (P>0.05). Intravenous saline infusion of [(123)I] MIBG could be a useful tool for controlling the administration rate, minimizing the side effects and lowering the exposure of the staff to ionizing radiation.
authors.affiliation: aRadiopharmacy Unit, Santa Lucia's Hospital, Cartagena bRadiopharmacy Unit, Virgen de la Arrixaca Hospital, Murcia, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Martínez
authors.forename: Tomás
authors.initials: T
authors.lastname: Chivato
authors.forename: Marta
authors.initials: M
authors.lastname: Roldán
authors.forename: Elena
authors.initials: E
authors.lastname: Miñana
mesh_terms: D019797:3-Iodobenzylguanidine / Q000737:chemistry*; D004355:Drug Stability; D007262:Infusions, Intravenous; D011854:Radiochemistry; D012965:Sodium Chloride / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D019797:3-Iodobenzylguanidine; D012965:Sodium Chloride