title: Alternating bouts of sitting and standing attenuate postprandial glucose responses.
abstract: OBJECTIVE
  This study aimed to examine whether reductions in sitting time through alternating 30-min bouts of sitting and standing can reduce postprandial glucose, insulin, and triglyceride responses.
  
  
  METHODS
  Twenty-three overweight/obese sedentary office workers (17 males and six females; mean ± SD: age, 48.2 ± 7.9 yr; body mass index, 29.6 ± 4.0 kg · m(-2)) undertook two short-term (5 d) experimental conditions in an equal, randomized (1:1) order. In a simulated office environment, participants performed typical occupational tasks for 8 h · d(-1) while in a 1) seated work posture (control condition) or 2) interchanging between a seated and standing work posture every 30 min using an electric, height-adjustable workstation (intervention condition). Fasting and postprandial blood samples after a mixed test drink were collected hourly for 4 h on days 1 and 5 of each condition to assess serum insulin, plasma glucose, and triglycerides. Dietary intake (kJ · d(-1)) and physical activity were standardized during each condition. The trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12611000632998).
  
  
  RESULTS
  After adjustment for time (days 1 and 5), incremental area under the analyte time curve differed significantly between conditions for plasma glucose (P = 0.007) but not for serum insulin or plasma triglycerides. Adjusted mean glucose incremental area under the analyte time curve was lowered by 11.1% after the intervention condition (6.38 mM · h(-1) (confidence interval, 5.04-7.71)) relative to the control condition (7.18 mM · h(-1) (confidence interval, 5.85-8.52)). No temporal changes (days 1 vs 5) between conditions were observed.
  
  
  CONCLUSIONS
  Alternating standing and sitting in 30-min bouts results in modest beneficial effects on postprandial glucose responses in overweight/obese office workers.
authors.affiliation: 1Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, AUSTRALIA; 2School of Public Health and Preventive Medicine, Monash University, Melbourne, AUSTRALIA; 3Department of Physiology, Monash University, Melbourne, AUSTRALIA; 4School of Population Health, University of Queensland, Brisbane, AUSTRALIA; 5School of Population and Global Health, Melbourne University, Melbourne, AUSTRALIA; 6School of Sport Science, Exercise and Health, University of Western Australia, Perth, AUSTRALIA; and 7School of Exercise and Nutrition Sciences, Deakin University, Melbourne, AUSTRALIA.
authors.forename: Alicia Ann
authors.initials: AA
authors.lastname: Thorp
authors.forename: Bronwyn A
authors.initials: BA
authors.lastname: Kingwell
authors.forename: Parneet
authors.initials: P
authors.lastname: Sethi
authors.forename: Louise
authors.initials: L
authors.lastname: Hammond
authors.forename: Neville
authors.initials: N
authors.lastname: Owen
authors.forename: David W
authors.initials: DW
authors.lastname: Dunstan
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000097:blood*; D019518:Postprandial Period; D011187:Posture / Q000502:physiology*; D057185:Sedentary Behavior; D014280:Triglycerides / Q000097:blood; D017132:Workplace
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides