title: Impact of Staphylococcus aureus on pathogenesis in polymicrobial infections.
abstract: Polymicrobial infections involving Staphylococcus aureus exhibit enhanced disease severity and morbidity. We reviewed the nature of polymicrobial interactions between S. aureus and other bacterial, fungal, and viral cocolonizers. Microbes that were frequently recovered from the infection site with S. aureus are Haemophilus influenzae, Enterococcus faecalis, Pseudomonas aeruginosa, Streptococcus pneumoniae, Corynebacterium sp., Lactobacillus sp., Candida albicans, and influenza virus. Detailed analyses of several in vitro and in vivo observations demonstrate that S. aureus exhibits cooperative relations with C. albicans, E. faecalis, H. influenzae, and influenza virus and competitive relations with P. aeruginosa, Streptococcus pneumoniae, Lactobacillus sp., and Corynebacterium sp. Interactions of both types influence changes in S. aureus that alter its characteristics in terms of colony formation, protein expression, pathogenicity, and antibiotic susceptibility.
authors.affiliation: Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences, AIMS-Edapally, Cochin, Kerala, India.
authors.forename: Nisha
authors.initials: N
authors.lastname: Nair
authors.forename: Raja
authors.initials: R
authors.lastname: Biswas
authors.forename: Friedrich
authors.initials: F
authors.lastname: Götz
authors.forename: Lalitha
authors.initials: L
authors.lastname: Biswas
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D060085:Coinfection / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents