title: Bovine Papillomavirus: New Insights into an Old Disease.
abstract: Bovine papillomaviruses (BPVs) are small DNA tumoral viruses able to induce benign cutaneous and/or mucosal epithelial lesions. Generally, the benign tumours affecting the skin or mucosa spontaneously regress, but under special circumstances, the defence system may be overwhelmed, thus leading to cancer, especially in the presence of immunosuppressant and mutagen agents from bracken fern. To date, thirteen different BPV genotypes have been associated with skin and mucosal tumours in cattle, and out of these, only four types (BPV-1, -2, -5 and -13) cross-infect other species. Recent investigations in vivo have revealed new insights into the epidemiology and pathogenesis of this viral infection. This review briefly discusses viral epidemiology, will give data on BPV genome structure and viral genes and will describe the cellular events and new aspects of both cutaneous and mucosal tumours in large ruminants. Finally, some aspects of active immunization will be described.
authors.affiliation: Department of Public Health, Faculty of Veterinary Medicine, University of Agriculture Sciences and Veterinary Medicine, Iasi, Romania.
authors.forename: F
authors.initials: F
authors.lastname: Bocaneti
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Napoli, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Altamura
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Napoli, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Corteggio
authors.affiliation: Department of Public Health, Faculty of Veterinary Medicine, University of Agriculture Sciences and Veterinary Medicine, Iasi, Romania.
authors.forename: E
authors.initials: E
authors.lastname: Velescu
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Napoli, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Roperto
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Napoli, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Borzacchiello
mesh_terms: D000818:Animals; D052688:Bovine papillomavirus 1 / Q000145:classification / Q000235:genetics; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000821:virology*; D005838:Genotype; D009369:Neoplasms / Q000662:veterinary* / Q000821:virology; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology
keywords: E5; bovine papillomavirus; viral oncology