title: Prostate stem cell antigen rs2294008 polymorphism differentially contributes toHelicobacter pylori-negative gastric cancer among various populations in China.
abstract: Gastric cancer is a lethal disease with a high mortality rate. Studies have suggested that prostate stem cell antigen (PSCA) rs2294008 polymorphism is associated with gastric cancer (GC). In this case-control study, we investigated rs2294008 polymorphism in the Tibet, Hui and Han nationalities in the Qinghai area of China. Genomic DNA was extracted from the peripheral blood of 286, 315 and 350 healthy volunteers and from 219, 233 and 265Helicobacter pylori-negative non-cardia GC patients from the Tibet, Hui and Han populations, respectively. The rs2294008 polymorphism was analyzed by denaturing high-performance liquid chromatography. rs2294008 CT and TT genotypes were associated with GC both in the Tibet and Han populations (adjusted OR=1.51, 1.47, 2.01, 1.85; 95% CI, 1.04-2.19, 1.05-2.06, 1.04-3.88, 1.03-3.34; P=0.030, 0.025, 0.039, 0.040, respectively). rs2294008 TT genotype was associated with GC in the Hui population (adjusted OR=2.14; 95% CI, 1.29-3.55; P=0.003). Furthermore, when stratified by histopathology, the rs2294008 CT and TT genotypes were associated with diffuse GC in the Tibet and Han nationalities (adjusted OR=1.93, 1.73, 2.69, 2.86; 95% CI, 1.09-3.44, 1.01-2.95, 1.06-6.84, 1.27-6.46; P=0.025, 0.045, 0.038, 0.011, respectively). However, the rs2294008 TT genotype was associated with both intestinal and diffuse types of GC (adjusted OR=2.10, 2.21; 95% CI, 1.17-3.75, 1.12-4.38; P=0.012, 0.023, respectively) and the rs2294008 CT genotype was only associated with intestinal-type GC in the Hui nationalitiy group (adjusted OR=1.60; 95% CI, 1.04-2.47; P=0.034). The results therefore showed that rs2294008 may differentially contribute to GC among different nationalities in one area and its role is independent fromHelicobacter pylori-infection.
authors.affiliation: Department of Internal Medicine-Oncology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, P.R. China ; ; High Altitude Medical Research Center, Qinghai University, Xining, Qinghai 810000, P.R. China ;
authors.forename: Jiuda
authors.initials: J
authors.lastname: Zhao
authors.affiliation: High Altitude Medical Research Center, Qinghai University, Xining, Qinghai 810000, P.R. China ;
authors.forename: Paili
authors.initials: P
authors.lastname: Geng
authors.affiliation: Department of Hematology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, P.R. China.
authors.forename: Zhanquan
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Hematology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, P.R. China.
authors.forename: Sen
authors.initials: S
authors.lastname: Cui
authors.affiliation: Department of Internal Medicine-Oncology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, P.R. China ;
authors.forename: Junhui
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Internal Medicine-Oncology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, P.R. China ;
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine-Oncology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, P.R. China ;
authors.forename: Jinzhang
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Internal Medicine-Oncology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, P.R. China ;
authors.forename: Faxiang
authors.initials: F
authors.lastname: Ji
authors.affiliation: Department of Internal Medicine-Oncology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, P.R. China ;
authors.forename: Guoyuan
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Internal Medicine-Oncology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, P.R. China ;
authors.forename: Guoshuang
authors.initials: G
authors.lastname: Shen
authors.affiliation: Department of Internal Medicine-Oncology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, P.R. China ;
authors.forename: Mingzhe
authors.initials: M
authors.lastname: Lin
authors.affiliation: High Altitude Medical Research Center, Qinghai University, Xining, Qinghai 810000, P.R. China ;
authors.forename: Cunfang
authors.initials: C
authors.lastname: Shen
keywords: gastric cancer; polymorphism; prostate stem cell antigen