title: Efficacy and tolerability of micafungin monotherapy for candidemia and deep-seated candidiasis in adults with cancer.
abstract: The response rate among 58 patients with cancer and candidemia or deep-seated candidiasis treated with micafungin monotherapy was 81%. Intensive care unit (ICU) stay, concomitant nonfungal infections, and acute kidney injury were significantly associated with the 30-day crude mortality rate. Severe neutropenia was an independent predictor of micafungin failure. The efficacy and safety of micafungin in cancer patients with invasive candidiasis were comparable to those reported for patients without malignancy and for cancer patients treated with caspofungin.
authors.affiliation: Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA dfarmakiotis@mdanderson.org dkontoyi@mdanderson.org.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Farmakiotis
authors.affiliation: Department of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Tarrand
authors.affiliation: Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA dfarmakiotis@mdanderson.org dkontoyi@mdanderson.org.
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D058387:Candidemia / Q000150:complications / Q000188:drug therapy*; D002177:Candidiasis / Q000188:drug therapy*; D058365:Candidiasis, Invasive / Q000150:complications / Q000188:drug therapy; D054714:Echinocandins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D055666:Lipopeptides / Q000627:therapeutic use*; D008297:Male; D000077551:Micafungin; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D009503:Neutropenia; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin