title: [Protective effect of 3-oxypyridine and succinic acid derivatives under conditions of acute alloxan-induced intoxication in mice].
abstract: Protective action of 3-oxypiridine and succinic acid derivatives (emoxipin, reamberin and mexidol) was studied in mice under acute alloxan-induced intoxication conditions. All these drugs exhibited protective action with respect to hyperglycemia and hyperglycemia-connected elongation of desperate behavior in the tail-suspension test and reduced activity level on the open field test. Mexidol exceeded emoxipin in the dose range of protecting action with respect to alloxan-induced hyperglycemia and was superior to reamberin in the treatment of desperate behavior in the tail-suspension test.
authors.forename: I A
authors.initials: IA
authors.lastname: Volchegorskiĭ
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Miroshnichenko
authors.forename: L M
authors.initials: LM
authors.lastname: Rassokhina
authors.forename: M P
authors.initials: MP
authors.lastname: Malkin
authors.forename: R M
authors.initials: RM
authors.lastname: Maĭzyllin
authors.forename: K E
authors.initials: KE
authors.lastname: Priakhina
authors.forename: A V
authors.initials: AV
authors.lastname: Kalugina
mesh_terms: D000496:Alloxan / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D006943:Hyperglycemia / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D051379:Mice; D011725:Pyridines / Q000494:pharmacology*; D013386:Succinates / Q000494:pharmacology*
chemical_list: C457919:3-oxypyridine; D011725:Pyridines; D013386:Succinates; D000496:Alloxan