title: Systems-level analysis of innate immunity.
abstract: Systems-level analysis of biological processes strives to comprehensively and quantitatively evaluate the interactions between the relevant molecular components over time, thereby enabling development of models that can be employed to ultimately predict behavior. Rapid development in measurement technologies (omics), when combined with the accessible nature of the cellular constituents themselves, is allowing the field of innate immunity to take significant strides toward this lofty goal. In this review, we survey exciting results derived from systems biology analyses of the immune system, ranging from gene regulatory networks to influenza pathogenesis and systems vaccinology.
authors.affiliation: Seattle BioMed, Seattle, Washington 98109; email: alan.aderem@seattlebiomed.org.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Zak
authors.forename: Vincent C
authors.initials: VC
authors.lastname: Tam
authors.forename: Alan
authors.initials: A
authors.lastname: Aderem
mesh_terms: D000818:Animals; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000209:etiology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D049490:Systems Biology / Q000379:methods; D014612:Vaccines / Q000276:immunology
chemical_list: D014612:Vaccines