title: [Epigenetic background of the most common non-oncologic gynecological diseases].
abstract: Epigenetic effects influence the function of genes regulating the main physiological mechanisms. Some of these environmental factors may reduce or inhibit the function of these genes. The environmental effects on gene function may result in a change of the DNA structure leading to non-heritable phenotype changes. Epigenetic factors play an important etiological role in the development of numerous diseases in obstetrics and gynecology. Uterine fibroids probably have a complex etiological background including epigenetic mechanisms. The multifactorial aetiology of endometriosis suggests key roles for immunological and hormonal factors in the development of the diseases. These mechanisms are influenced by epigenetic factors, which may serve as therapeutic targets in the future. The possible in utero origin of polycystic ovary syndrome determines the main directions of research concerning epigenetic factors in the etiological background, with the hope of eventual prevention and/or treatment in the preconceptional period as well as during pregnancy care.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Szülészeti és Nőgyógyászati Klinika Budapest Baross u. 27. 1088.
authors.forename: József Gábor
authors.initials: JG
authors.lastname: Joó
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Szülészeti és Nőgyógyászati Klinika Budapest Baross u. 27. 1088.
authors.forename: Eva
authors.initials: E
authors.lastname: Csatlós
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Szülészeti és Nőgyógyászati Klinika Budapest Baross u. 27. 1088.
authors.forename: Réka
authors.initials: R
authors.lastname: Brubel
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Szülészeti és Nőgyógyászati Klinika Budapest Baross u. 27. 1088.
authors.forename: Attila
authors.initials: A
authors.lastname: Bokor
authors.affiliation: Biotest Hungaria Budapest.
authors.forename: Csaba
authors.initials: C
authors.lastname: Karabélyos
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Szülészeti és Nőgyógyászati Klinika Budapest Baross u. 27. 1088.
authors.forename: János
authors.initials: J
authors.lastname: Rigó
mesh_terms: D002843:Chromatin / Q000235:genetics; D019175:DNA Methylation; D004715:Endometriosis / Q000235:genetics*; D044127:Epigenesis, Genetic; D057890:Epigenomics / Q000639:trends*; D005260:Female; D005831:Genital Diseases, Female / Q000235:genetics; D006657:Histones / Q000235:genetics; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011247:Pregnancy; D022661:RNA, Untranslated / Q000235:genetics
chemical_list: D002843:Chromatin; D006657:Histones; D022661:RNA, Untranslated
keywords: DNA-methylation; DNS-metiláció; PCOS; endometriosis; epigenetics; epigenetika; leiomyoma uteri; miRNS; microRNA; uterine fibroid