title: Viruses for tumor therapy.
abstract: Oncolytic virotherapy exploits live viruses with selective tropism for cancerous cells and tissues to treat cancer. As discussed here, the field has progressed considerably as a result of both the successes and failures of previous and on-going clinical trials for various cancers. These studies indicate that oncolytic viruses are remarkably safe and more efficacious when virus replication stimulates sustained antitumor immune responses. In the future, virotherapy should be combined with immunomodulatory reagents that target immune tolerance to established cancers.
authors.affiliation: Center for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Bell
authors.affiliation: Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA. Electronic address: grantmcf@ufl.edu.
authors.forename: Grant
authors.initials: G
authors.lastname: McFadden
mesh_terms: D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy / Q000379:methods; D007155:Immunologic Factors / Q000627:therapeutic use; D009369:Neoplasms / Q000628:therapy*; D050130:Oncolytic Virotherapy / Q000379:methods*; D050504:Oncolytic Viruses / Q000254:growth & development / Q000502:physiology*; D016896:Treatment Outcome; D056189:Viral Tropism
chemical_list: D007155:Immunologic Factors