title: Assessment of cerebral tissue oxygen saturation in septic patients during acetazolamide provocation - a near infrared spectroscopy study.
abstract: Sepsis-associated encephalopathy is a multifactorially determined process of the brain parenchyma. Among other factors, vasogenic causes have been shown to play a role in its development. The aim of the present work was to assess whether cerebral tissue oxygen saturation is influenced by administration of acetazolamide in septic patients compared to controls.
  
  
  METHODS
  15 patients with severe sepsis and 10 healthy controls were studied. Cerebral oxygen saturation was assessed by INVOS 51 OOC Cerebral Oxymeter (NIRS) before and after administration of 15 mg/kg BW acetazolamide in both groups.
  
  
  RESULTS
  The maximal rise that has been found in the partial pressure of CO(2) in the arterial blood of septic patients after administration of acetazolamide was from 35 ± 5 mmHg to 41.1 ± 6.3 mmHg. For the partial pressure of O(2) the observed increase was from 123.7 ± 47.1 mmHg to 139.9 ± 49 mmHg. Vasodilatory stimulus resulted in a similar maximal increase in cerebral oxygen saturation in septic patients and in controls (8.9 ± 6.5% for septic patients and 9.2 ± 4.6% for healthy persons, respectively).
  
  
  CONCLUSIONS
  Cerebral vasoreactivity to acetazolamide is preserved in patients with severe sepsis.
authors.affiliation: University of Debrecen Department of Anesthesiology and Intensive Care, Health and Medical Science Centre Nagyerdei krt. 98 H-4032 Debrecen Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Vaskó
authors.affiliation: University of Debrecen Department of Anesthesiology and Intensive Care, Health and Medical Science Centre Nagyerdei krt. 98 H-4032 Debrecen Hungary.
authors.forename: P
authors.initials: P
authors.lastname: Siró
authors.affiliation: University of Debrecen Department of Anesthesiology and Intensive Care, Health and Medical Science Centre Nagyerdei krt. 98 H-4032 Debrecen Hungary.
authors.forename: I
authors.initials: I
authors.lastname: László
authors.affiliation: University of Debrecen Department of Anesthesiology and Intensive Care, Health and Medical Science Centre Nagyerdei krt. 98 H-4032 Debrecen Hungary.
authors.forename: Sz
authors.initials: S
authors.lastname: Szatmári
authors.affiliation: University of Debrecen Department of Anesthesiology and Intensive Care, Health and Medical Science Centre Nagyerdei krt. 98 H-4032 Debrecen Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Molnár
authors.affiliation: University of Debrecen Department of Anesthesiology and Intensive Care, Health and Medical Science Centre Nagyerdei krt. 98 H-4032 Debrecen Hungary.
authors.forename: Béla
authors.initials: B
authors.lastname: Fülesdi
authors.affiliation: University of Debrecen Department of Anesthesiology and Intensive Care, Health and Medical Science Centre Nagyerdei krt. 98 H-4032 Debrecen Hungary.
authors.forename: Cs
authors.initials: C
authors.lastname: Molnár
mesh_terms: D000086:Acetazolamide / Q000008:administration & dosage*; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage*; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004660:Encephalitis / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000187:drug effects*; D010313:Partial Pressure; D011237:Predictive Value of Tests; D018805:Sepsis / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D012720:Severity of Illness Index; D019265:Spectroscopy, Near-Infrared; D014664:Vasodilation / Q000187:drug effects
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D002245:Carbon Dioxide; D000086:Acetazolamide; D010100:Oxygen
keywords: acetazolamide; cerebral vasoreactivity; near-infrared spectroscopy; sepsis; sepsis-associated encephalopathy