title: Retrospective analysis of capecitabine and oxaliplatin (XELOX) plus bevacizumab as a first-line treatment for Japanese patients with metastatic colorectal cancer.
abstract: XELOX plus bevacizumab is an effective treatment strategy and has a manageable tolerability profile when administered to Japanese patients with metastatic colorectal cancer (mCRC). In this study, we retrospectively reviewed cases in which XELOX plus bevacizumab were administered in order to evaluate its efficacy and safety in clinical practice. In total, 40 patients with mCRC who presented at Fuchu Hospital received XELOX plus bevacizumab as a first-line treatment between September, 2009 and April, 2012. Eligible patients had histologically confirmed mCRC. XELOX consisted of a 2-h intravenous infusion of oxaliplatin 130 mg/m2on day 1 plus oral capecitabine 1,000 mg/m2twice daily for 2 weeks of a 3-week cycle. Overall survival (OS) and survival benefit were analyzed when patients continued with XELOX plus bevacizumab beyond disease progression. The median progression-free survival (PFS) was 290 days [95% confidence interval (CI): 222-409 days] and the median OS was 816 days (95% CI: 490 days-not calculated). The response rate (RR; complete plus partial response) was 67.5%, and the disease control rate (RR plus stable disease) was 90%. The most common adverse events observed following administration of XELOX plus bevacizumab were neurosensory toxicity (82.5%), anorexia (50%), hypertension (45%) and a decrease in the platelet count (40%). The most common grade 3/4 adverse events were neurosensory toxicity (15%) and fatigue (15%). In conclusion, XELOX plus bevacizumab may be considered a routine first-line treatment option for patients with mCRC. Notably, the combination of capecitabine and bevacizumab was safe with an acceptable toxicity profile and induced a significant rate of disease control.
authors.affiliation: Department of Surgery, Fuchu Hospital, Izumi, Osaka 5940076, Japan.
authors.forename: Yasutake
authors.initials: Y
authors.lastname: Uchima
authors.affiliation: Department of Surgery, Fuchu Hospital, Izumi, Osaka 5940076, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nishii
authors.affiliation: Department of Surgery, Fuchu Hospital, Izumi, Osaka 5940076, Japan.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Iseki
authors.affiliation: Department of Surgery, Fuchu Hospital, Izumi, Osaka 5940076, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Ishii
authors.affiliation: Department of Surgery, Fuchu Hospital, Izumi, Osaka 5940076, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Hiramatsu
authors.affiliation: Department of Surgery, Fuchu Hospital, Izumi, Osaka 5940076, Japan.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Iwauchi
authors.affiliation: Department of Surgery, Fuchu Hospital, Izumi, Osaka 5940076, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Morimoto
authors.affiliation: Department of Surgery, Fuchu Hospital, Izumi, Osaka 5940076, Japan.
authors.forename: Kinshi
authors.initials: K
authors.lastname: Kosaka
authors.affiliation: Department of Surgery, Fuchu Hospital, Izumi, Osaka 5940076, Japan.
authors.forename: Seika
authors.initials: S
authors.lastname: Tei
authors.affiliation: Department of Surgery, Fuchu Hospital, Izumi, Osaka 5940076, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takeuchi
keywords: bevacizumab; capecitabine; colorectal cancer; oxaliplatin