title: Anoctamin 1 in secretory epithelia.
abstract: Fluid and electrolyte releasing from secretory epithelia are elaborately regulated by orchestrated activity of ion channels. The activity of chloride channel at the apical membrane decides on the direction and the rate of secretory fluid and electrolyte. Chloride-dependent secretion is conventionally associated with intracellular increases in two second messengers, cAMP and Ca(2+), responding to luminal purinergic and basolateral adrenergic or cholinergic stimulation. While it is broadly regarded that cAMP-dependent Cl(-) secretion is regulated by cystic fibrosis transmembrane conductance regulator (CFTR), Ca(2+)-activated Cl(-) channel (CaCC) had been veiled for quite some time. Now, Anoctamin 1 (ANO1 or TMEM16A) confers Ca(2+)-activated Cl(-) currents. Ano 1 and its paralogs have been actively investigated for multiple functions underlying Ca(2+)-activated Cl(-) efflux and fluid secretion in a variety of secretory epithelial cells. In this review, we will discuss recent advances in the secretory function and signaling of ANO1 in the secretory epithelia, such as airways, intestines, and salivary glands.
authors.affiliation: Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
authors.forename: Yongwoo
authors.initials: Y
authors.lastname: Jang
authors.affiliation: Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Republic of Korea. Electronic address: utoh@snu.ac.kr.
authors.forename: Uhtaek
authors.initials: U
authors.lastname: Oh
mesh_terms: D002118:Calcium / Q000378:metabolism; D018118:Chloride Channels / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D009077:Mucins / Q000378:metabolism; D020545:Respiratory Mucosa / Q000378:metabolism; D012469:Salivary Glands / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018118:Chloride Channels; D009077:Mucins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D000242:Cyclic AMP; D002118:Calcium
keywords: Airway epithelium; Anoctamin1; Ca(2+)-activated Cl(−) channel; Fluid secretion; Intestinal epithelium; Salivary gland acinar cell; TMEM16A