title: Effect of intraoperative paracetamol on catheter-related bladder discomfort: a prospective, randomized, double-blind study.
abstract: BACKGROUND
  The insertion of urinary catheters during urinary surgical interventions may lead to catheter-related bladder discomfort (CRBD) in the postoperative period.
  
  
  OBJECTIVE
  We aimed to evaluate the effect of single-dose intravenous paracetamol on CRBD.
  
  
  METHODS
  In this randomized, controlled, double-blind study, 64 patients (age >18 years, American Society of Anesthesiologists Physical Status I-II) requiring urinary bladder catheterization for percutaneous nephrolithotomy were assigned to groups that received either intravenous paracetamol (15 mg/kg) (group P) or NaCl 0.9% solution (control group [group C]) 30 minutes before the end of surgery. Patients received patient-controlled analgesia (10-mg bolus of meperidine, without infusion, 20-minute lock out) postoperatively. CRBD and pain status were assessed at 30 minutes and 1, 2, 4, 6, and 12 hours postoperatively. Postoperative meperidine requirement and patient and surgeon satisfaction were assessed.
  
  
  RESULTS
  Group P had significantly lower CRBD scores at all time points except at 12 hours postoperatively compared with group C (P < 0.05). Total meperidine consumption was significantly higher in group C (P < 0.05). Patient and surgeon satisfaction scores were significantly higher in group P (P < 0.05).
  
  
  CONCLUSIONS
  Intraoperative single-dose paracetamol was found to be effective in reducing the severity of CRBD and pain in urologic surgery. We suggest that it may be an efficient, reliable, easy-to-apply drug for CRBD. ClinicalTrials.gov identifier: NCT01652183.
authors.affiliation: Anesthesiology and Reanimation Department, Baskent University School of Medicine, Adana,Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Ergenoglu
authors.affiliation: Anesthesiology and Reanimation Department, Baskent University School of Medicine, Adana,Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Akin
authors.affiliation: Anesthesiology and Reanimation Department, Baskent University School of Medicine, Adana,Turkey.
authors.forename: Oya
authors.initials: O
authors.lastname: Yalcin Cok
authors.affiliation: Anesthesiology and Reanimation Department, Baskent University School of Medicine, Adana,Turkey.
authors.forename: Evren
authors.initials: E
authors.lastname: Eker
authors.affiliation: Department of Urology, Baskent University School of Medicine, Adana, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Kuzgunbay
authors.affiliation: Department of Urology, Baskent University School of Medicine, Adana, Turkey.
authors.forename: Tahsin
authors.initials: T
authors.lastname: Turunc
authors.affiliation: Anesthesiology and Reanimation Department, Baskent University School of Medicine, Adana,Turkey.
authors.forename: Anis
authors.initials: A
authors.lastname: Aribogan
keywords: catheter-related bladder discomfort; intravenous paracetamol; urologic surgery