title: Staged total callosotomy for lennox-gastaut syndrome: a case report.
abstract: We report a case with Lennox-Gastaut syndrome (LGS) who underwent staged total callosotomy with a favorable outcome. A 6-year-old boy began having myoclonic seizures at the age of 8 months and was diagnosed with LGS when he was 27 months old. Various antiepileptic drugs and a ketogenic diet failed to control his multiple types of seizures. At the age of 36 months, he underwent corpus callosotomy and achieved an immediate, post-operative seizure free state. However, 3 months later, various seizures relapsed and were refractory to additional vagus nerve stimulation. Remaining callosal fibers in the splenium noted on post-operative diffusion tensor imaging made us to perform a second operation, total callosotomy. The patient finally achieved a seizure-free state with electroencephalography (EEG) normalization noted after the staged total callosotomy.
authors.affiliation: Department of Pediatrics, College of Medicine, Kyung Hee University;
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, Asan Medical Center, Children's Hospital, University of Ulsan College of Medicine;
authors.forename: Mi-Sun
authors.initials: MS
authors.lastname: Yum
authors.affiliation: Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine;
authors.forename: Seok-Ho
authors.initials: SH
authors.lastname: Hong
authors.affiliation: Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine;
authors.forename: Jeong-Kyo
authors.initials: JK
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, Epilepsy Center, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
authors.forename: Su Jeong
authors.initials: SJ
authors.lastname: You
authors.affiliation: Department of Pediatrics, Asan Medical Center, Children's Hospital, University of Ulsan College of Medicine;
authors.forename: Tae-Sung
authors.initials: TS
authors.lastname: Ko
keywords: Callosotomy; Lennox-Gastaut syndrome