title: Fast-dissolving core-shell composite microparticles of quercetin fabricated using a coaxial electrospray process.
abstract: This study reports on novel fast-dissolving core-shell composite microparticles of quercetin fabricated using coaxial electrospraying. A PVC-coated concentric spinneret was developed to conduct the electrospray process. A series of analyses were undertaken to characterize the resultant particles in terms of their morphology, the physical form of their components, and their functional performance. Scanning and transmission electron microscopies revealed that the microparticles had spherical morphologies with clear core-shell structure visible. Differential scanning calorimetry and X-ray diffraction verified that the quercetin active ingredient in the core and sucralose and sodium dodecyl sulfate (SDS) excipients in the shell existed in the amorphous state. This is believed to be a result of second-order interactions between the components; these could be observed by Fourier transform infrared spectroscopy. In vitro dissolution and permeation studies showed that the microparticles rapidly released the incorporated quercetin within one minute, and had permeation rates across the sublingual mucosa around 10 times faster than raw quercetin.
authors.affiliation: Institute of Biotechnology, Shanxi University, Taiyuan, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.affiliation: School of Materials & Engineering, University of Shanghai for Science and Technology, Shanghai, China.
authors.forename: Deng-Guang
authors.initials: DG
authors.lastname: Yu
authors.affiliation: UCL School of Pharmacy, London, United Kingdom.
authors.forename: Gareth R
authors.initials: GR
authors.lastname: Williams
authors.affiliation: Institute of Biotechnology, Shanxi University, Taiyuan, China.
authors.forename: Zhuan-Hua
authors.initials: ZH
authors.lastname: Wang
mesh_terms: D000818:Animals; D001692:Biological Transport; D015194:Diffusion Chambers, Culture; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D005079:Excipients; D007700:Kinetics; D009061:Mouth Mucosa / Q000378:metabolism*; D065568:Oral Mucosal Absorption; D010539:Permeability; D011143:Polyvinyl Chloride; D011794:Quercetin / Q000737:chemistry* / Q000378:metabolism; D012967:Sodium Dodecyl Sulfate; D013395:Sucrose / Q000031:analogs & derivatives; D013552:Swine
chemical_list: D004337:Drug Carriers; D005079:Excipients; D012967:Sodium Dodecyl Sulfate; D013395:Sucrose; D011143:Polyvinyl Chloride; C026285:trichlorosucrose; D011794:Quercetin