title: Intrinsically disordered proteins implicated in paramyxoviral replication machinery.
abstract: The development of mechanistic insight into the molecular basis of how intrinsically disordered proteins function is a key challenge for contemporary molecular biology. Intrinsic protein disorder is abundant in the replication machinery of paramyxoviruses. In order to study this kind of protein, new methods are required that specifically take account of the highly dynamic nature of the chain, and describe this disorder in quantitative terms. Here we review recent studies of conformational disorder in paramyxoviral phosphoproteins and nucleoproteins using solution-based approaches such as nuclear magnetic resonance.
authors.affiliation: Université Grenoble Alpes, Institut de Biologie Structurale (IBS), Grenoble, France; CEA, DSV, IBS, Grenoble, France; CNRS, IBS, Grenoble, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Communie
authors.affiliation: Université Grenoble Alpes, UVHCI, Grenoble, France; CNRS, UVHCI, Grenoble, France; Unit for Virus Host-Cell Interactions, Université Grenoble Alpes-EMBL-CNRS, Grenoble, France.
authors.forename: Rob W H
authors.initials: RW
authors.lastname: Ruigrok
authors.affiliation: Université Grenoble Alpes, Institut de Biologie Structurale (IBS), Grenoble, France; CEA, DSV, IBS, Grenoble, France; CNRS, IBS, Grenoble, France.
authors.forename: Malene Ringkjøbing
authors.initials: MR
authors.lastname: Jensen
authors.affiliation: Université Grenoble Alpes, Institut de Biologie Structurale (IBS), Grenoble, France; CEA, DSV, IBS, Grenoble, France; CNRS, IBS, Grenoble, France. Electronic address: martin.blackledge@ibs.fr.
authors.forename: Martin
authors.initials: M
authors.lastname: Blackledge
mesh_terms: D000818:Animals; D006801:Humans; D064267:Intrinsically Disordered Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010252:Paramyxoviridae / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018184:Paramyxoviridae Infections / Q000821:virology; D011487:Protein Conformation; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D064267:Intrinsically Disordered Proteins; D014764:Viral Proteins