title: Diterpenes inhibiting NO production from Euphorbia helioscopia.
abstract: Three new jatrophane diterpenes (1-3), an unreported spectroscopic data jatrophane diterpenene (4), and nine known analogues (5-13) have been isolated from the whole plants of Euphorbia helioscopia. Their structures were established by detailed spectroscopic data analyses (IR, ESIMS, HR-ESIMS, and 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The diterpenes showed inhibitory activities on LPS-induced NO production in murine microglial BV-2 cells.
authors.affiliation: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China; College of Pharmacy, Harbin University of Commerce, Harbin 150076, China.
authors.forename: Hongqiang
authors.initials: H
authors.lastname: Chen
authors.affiliation: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Harbin University of Commerce, Harbin 150076, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Jin
authors.affiliation: College of Pharmacy, Harbin University of Commerce, Harbin 150076, China.
authors.forename: Shuliang
authors.initials: S
authors.lastname: Yang
authors.affiliation: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
authors.forename: Meicheng
authors.initials: M
authors.lastname: Wang
authors.affiliation: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China. Electronic address: xujing611@nankai.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohizumi
authors.affiliation: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China. Electronic address: victgyq@nankai.edu.cn.
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000818:Animals; D002460:Cell Line; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D051379:Mice; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal
chemical_list: D004224:Diterpenes; D008070:Lipopolysaccharides; D010936:Plant Extracts; C530345:jatrophane; D009569:Nitric Oxide
keywords: Diterpene; Euphorbia helioscopia; Inhibitory effects on NO production; Jatrophane diterpene