title: [The resistance of low brainstem tissue to free radical oxidation in rats during periodic breathing following hydroxybutyrate treatment].
abstract: We evaluated tissue resistance to free radical oxidation, in pentobarbital-anesthetized mongrel albino male rats during pathologic periodic breathing following hydroxybutyrate (GHBA) administration. It was shown that GHBA modulated pro- and antioxidant status of brain tissue. In the absence of periodic breathing after GHBA, decreases in resistance of brainstem tissue membranes to induction of free radical oxidation were slightly pronounced. Rats with GHBA-induced periodic breathing exhibited increased membrane sensitivity of medullar neurons to induction of free radical oxidation. We suggest that cellular metabolism and/or membrane mechanisms of respiratory rhythm-generating neurons play a role in the pathogenesis of periodic breathing.
authors.forename: I A
authors.initials: IA
authors.lastname: Tarakanov
authors.forename: L N
authors.initials: LN
authors.lastname: Tikhomirova
authors.forename: A G
authors.initials: AG
authors.lastname: Zhukova
authors.forename: V A
authors.initials: VA
authors.lastname: Safonov
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D002462:Cell Membrane / Q000378:metabolism / Q000473:pathology; D005609:Free Radicals / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000633:toxicity*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D012120:Respiration Disorders / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D005609:Free Radicals; D006885:Hydroxybutyrates