title: One-pot organocatalytic enantioselective Michael/Povarov domino strategy for the construction of spirooctahydroacridine-3,3'-oxindole scaffolds.
abstract: An asymmetric organocatalytic one-pot strategy for the construction of spirooctahydroacridine-3,3'-oxindole scaffolds has been successfully developed by means of a domino Michael/Povarov reaction sequence. The one-pot protocol affords the chiral spirocyclohexaneoxindoles bearing an octahydroacridine motif with five stereocenters in good to high yields (up to 89 % yield) with excellent to perfect diastereoselectivities (up to >20:1 d.r.) and enantioselectivities (up to >99 % ee). This highly efficient one-pot domino procedure will allow diversity-oriented syntheses of this intriguing class of compounds with potential biological activities.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Department of Chemistry, Nankai University, Tianjin 300071 (China), Fax: (+86) 22-23504439.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Wang
keywords: Michael reaction; Povarov reaction; domino reactions; organocatalysis; spirooctahydroacridine-3,3′-oxindoles