title: Select aging biomarkers based on telomere length and chronological age to build a biological age equation.
abstract: The purpose of this study is to build a biological age (BA) equation combining telomere length with chronological age (CA) and associated aging biomarkers. In total, 139 healthy volunteers were recruited from a Chinese Han cohort in Beijing. A genetic index, renal function indices, cardiovascular function indices, brain function indices, and oxidative stress and inflammation indices (C-reactive protein [CRP]) were measured and analyzed. A BA equation was proposed based on selected parameters, with terminal telomere restriction fragment (TRF) and CA as the two principal components. The selected aging markers included mitral annulus peak E anterior wall (MVEA), intima-media thickness (IMT), cystatin C (CYSC), D-dimer (DD), and digital symbol test (DST). The BA equation was: BA = −2.281TRF + 26.321CYSC + 0.025DD − 104.419MVEA + 34.863IMT − 0.265DST + 0.305CA + 26.346. To conclude, telomere length and CA as double benchmarks may be a new method to build a BA.
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Zhang
authors.forename: Shu-Ying
authors.initials: SY
authors.lastname: Zhu
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Bai
authors.forename: De-Long
authors.initials: DL
authors.lastname: Zhao
authors.forename: Shi-Min
authors.initials: SM
authors.lastname: Jian
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Zuo-Xiang
authors.initials: ZX
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Fu
authors.forename: Guang-Yan
authors.initials: GY
authors.lastname: Cai
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Sun
authors.forename: Xiang-Mei
authors.initials: XM
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000235:genetics*; D012189:Retrospective Studies; D016615:Telomere / Q000235:genetics* / Q000378:metabolism
chemical_list: D015415:Biomarkers