title: Prognostic factors in metastatic pancreatic cancer: Older patients are associated with reduced overall survival.
abstract: Pancreatic cancer is a major health concern worldwide and, despite the attempts at management, the prognosis of patients with metastatic pancreatic cancer remains poor, with a median survival of a few months. The aim of this study was to identify and evaluate clinicopathological factors and elucidate the clinical significance of patient age for the outcome of metastatic pancreatic cancer. Data from a total of 154 metastatic patients with a histologically confirmed diagnosis of pancreatic cancer, who were treated and followed-up in our clinic, were recorded from medical charts. The patient sample included 102 (66%) males with a median age of 58 years (range, 25-88 years). The majority of the patients had a poor performance status (64%), weight loss of >10% body weight (74%), tumor size of >3 cm (75%) and elevated tumor markers, including carcinoembryonic antigen (CEA) (66%) and carbohydrate antigen 19-9 (CA19-9) (85%). The distributions of prognostic factors depending on patient age were largely identical. The median survival time of patients with metastatic disease was 179 days and the 1-year survival rate was 7%. The median survival time of elderly patients was significantly lower compared to younger patients (148 vs. 198 days, respectively; P=0.039). The 1-year survival rates in elderly and younger patients were 3 and 10%, respectively. In the univariate and multivariate analyses, elderly patients had poorer outcomes compared with younger patients (P=0.04 and 0.05, respectively). In all patients, the univariate analysis demonstrated that similar prognostic factors, including the performance status of the patients and tumor markers, such as serum CEA and CA19-9 levels, were associated with survival. In the multivariate analysis, younger patients with a poor performance status had a significantly shorter overall survival compared to those with a good performance status (P=0.008). However, no significant prognostic factor affecting the outcome was identified in the elderly patients. In conclusion, patient age is a major prognostic factor affecting the survival of patients with metastatic pancreatic cancer and elderly patients without poor prognostic factors may be eligible for the available treatment options.
authors.affiliation: Institute of Oncology, University of Istanbul, 34390 Istanbul, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Tas
authors.affiliation: Institute of Oncology, University of Istanbul, 34390 Istanbul, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Sen
authors.affiliation: Institute of Oncology, University of Istanbul, 34390 Istanbul, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Keskin
authors.affiliation: Institute of Oncology, University of Istanbul, 34390 Istanbul, Turkey.
authors.forename: Leyla
authors.initials: L
authors.lastname: Kilic
authors.affiliation: Institute of Oncology, University of Istanbul, 34390 Istanbul, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Yildiz
keywords: elderly; metastatic; pancreatic cancer; prognostic factor; survival