title: Association of -108 C>TPON1polymorphism with polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) is possibly the most common endocrine disorder in premenopausal women. In this study, we aimed to investigate the association of the -108 C>T polymorphism in thePON1gene, which encodes the antioxidant enzyme paraoxonase-1, with PCOS. A total of 118 women with PCOS and 108 control subjects were included in this case-control study. ThePON1polymorphism was genotyped, biochemical and clinical parameters were determined and the correlations between the parameters were statistically evaluated. The differences in thePON1allele and genotype distributions between PCOS patients and controls did not reach a statistical significance. The serum fasting glucose (GLU) levels did not differ significantly between the PCOS patients and the controls. However, the serum fasting insulin (INS) concentration, INS/GLU ratio and homeostasis model assessment (HOMA) index, although within the normal range, were significantly higher in the PCOS group. When considering PCOS patients and controls as separate groups or as a single group of patients, none of the analyzed biochemical or clinical parameters were found to be significantly correlated with thePON1polymorphism. Therefore, the -108 C>TPON1polymorphism was not found to be significantly associated with the presence of PCOS or with its particular clinical and biochemical characteristics in non-insulin resistant, non-obese patients.
authors.affiliation: Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
authors.forename: Polonca
authors.initials: P
authors.lastname: Ferk
authors.affiliation: Department of Obstetrics and Gynaecology, Ljubljana University Medical Centre, Ljubljana, Slovenia ; Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Ksenija
authors.initials: K
authors.lastname: Gersak
keywords: -108 C>T PON1 polymorphism; oxidative stress; paraoxonase-1; polycystic ovary syndrome