title: Efficacy and safety of antiplatelet-combination therapy after drug-eluting stent implantation.
abstract: OBJECTIVE
  Combination single-pill therapy can improve cost-effectiveness in a typical medical therapy. However, there is a little evidence about the efficacy and tolerability of combination single-pill antiplatelet therapy after percutaneous coronary intervention (PCI) with drug-eluting stents (DES).
  
  
  METHODS
  From June to November 2012, in total, 142 patients who met the following criteria were enrolled: at least 18 years old; successful PCI with DES at least 3 months earlier; and regular medication of aspirin and clopidogrel with no side effects. After VerifyNow P2Y12 and aspirin assays, the combination single pill of aspirin and clopidogrel was given and laboratory tests were repeated 6 weeks later.
  
  
  RESULTS
  At baseline, the incidence of aspirin resistance, defined as aspirin reaction unit (ARU) ≥ 550, was 9.2%, that of clopidogrel resistance, defined as P2Y12 reaction unit (PRU) ≥ 230, was 46.5%, and that of percent inhibition of PRU < 20% was 32.4%. At follow-up, the incidence of resistance by ARU value was 7.0%, 50.0% by PRU value, and 35.9% by percentage inhibition of PRU, respectively. The mean values of ARU (431.5 ± 63.6 vs. 439.8 ± 55.2; p = 0.216) and PRU (227.5 ± 71.4 vs. 223.3 ± 76.0; p = 0.350) were not significantly different before versus after antiplatelet-combination single-pill therapy. Five adverse events (3.5%) were observed during the study period.
  
  
  CONCLUSIONS
  Combination single-pill antiplatelet therapy, which may reduce daily pill burden for patients after PCI with DES, demonstrated similar efficacy to separate dual-pill antiplatelet therapy.
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Yun-Kyeong
authors.initials: YK
authors.lastname: Cho
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Chang-Wook
authors.initials: CW
authors.lastname: Nam
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Hyoung-Seob
authors.initials: HS
authors.lastname: Park
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Hyuck-Jun
authors.initials: HJ
authors.lastname: Yoon
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Hyungseop
authors.initials: H
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Hur
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Yoon-Nyun
authors.initials: YN
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Kyungpook National University Hospital, Daegu, Korea.
authors.forename: Jang-Hoon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Kyungpook National University Hospital, Daegu, Korea.
authors.forename: Dong-Heon
authors.initials: DH
authors.lastname: Yang
authors.affiliation: Division of Cardiology, Daegu Fatima Hospital, Daegu, Korea.
authors.forename: Bong-Ryeol
authors.initials: BR
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Daegu Fatima Hospital, Daegu, Korea.
authors.forename: Byung-Chun
authors.initials: BC
authors.lastname: Jung
authors.affiliation: Division of Cardiology, Yeungnam University Hospital, Daegu, Korea.
authors.forename: Woong
authors.initials: W
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Yeungnam University Hospital, Daegu, Korea.
authors.forename: Jong-Seon
authors.initials: JS
authors.lastname: Park
authors.affiliation: Division of Cardiology, Daegu Catholic University Hospital, Daegu, Korea.
authors.forename: Jin-Bae
authors.initials: JB
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Daegu Catholic University Hospital, Daegu, Korea.
authors.forename: Kee-Sik
authors.initials: KS
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Kwon-Bae
authors.initials: KB
authors.lastname: Kim
mesh_terms: D000368:Aged; D000980:Antiplatyhelmintic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects; D000077144:Clopidogrel; D004338:Drug Combinations; D004351:Drug Resistance; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D057194:Intention to Treat Analysis; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation*; D010979:Platelet Function Tests; D011446:Prospective Studies; D013607:Tablets; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000980:Antiplatyhelmintic Agents; D004338:Drug Combinations; D013607:Tablets; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin
keywords: Aspirin; Clopidogrel; Drug combinations