title: Integrative clinical transcriptomics analyses for new therapeutic intervention strategies: a psoriasis case study.
abstract: Psoriasis is a chronic inflammatory skin disease with complex pathological features and unmet pharmacotherapy needs. Here, we present a framework for developing new therapeutic intervention strategies for psoriasis by utilizing publicly available clinical transcriptomics data sets. By exploring the underlying molecular mechanisms of psoriasis, the effects of subsequent perturbation of these mechanisms by drugs and an integrative analysis, we propose a psoriasis disease signature, identify potential drug repurposing opportunities and present novel target selection methodologies. We anticipate that the outlined methodology or similar approaches will further support biomarker discovery and the development of new drugs for psoriasis.
authors.affiliation: Computational Biology, Quantitative Sciences, GlaxoSmithKline R&D, RTP, NC, USA.
authors.forename: Xiaoyan A
authors.initials: XA
authors.lastname: Qu
authors.affiliation: Computational Biology, Quantitative Sciences, GlaxoSmithKline R&D, RTP, NC, USA.
authors.forename: Johannes M
authors.initials: JM
authors.lastname: Freudenberg
authors.affiliation: Computational Biology, Quantitative Sciences, GlaxoSmithKline R&D, Stevenage, UK.
authors.forename: Philippe
authors.initials: P
authors.lastname: Sanseau
authors.affiliation: Computational Biology, Quantitative Sciences, GlaxoSmithKline R&D, RTP, NC, USA. Electronic address: Deepak.K.Rajpal@gsk.com.
authors.forename: Deepak K
authors.initials: DK
authors.lastname: Rajpal
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D003879:Dermatologic Agents / Q000494:pharmacology*; D015195:Drug Design; D058492:Drug Repositioning; D006801:Humans; D058990:Molecular Targeted Therapy; D011565:Psoriasis / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D059467:Transcriptome
chemical_list: D015415:Biomarkers; D003879:Dermatologic Agents