title: Risk factors of stroke and -717A>G (rs2794521) CRP gene polymorphism among stroke patients in West Pomerania province of Poland.
abstract: OBJECTIVE
  Some of the risk factors of ischaemic stroke influence the development of atherosclerosis, which is a significant cause of vascular incidents. An inflammatory component plays a role in pathogenesis of both atherosclerosis and atrial fibrillation, the most important risk factor of embolic strokes. C-reactive protein (CRP) concentration in blood reflects the inflammatory process. Concentration of this protein depends on the CRP gene polymorphism. The aim of the study was to assess the relationship between selected risk factors of stroke and variant of -717A>G (rs2794521) CRP gene polymorphism in population of West Pomerania Province of Poland.
  
  
  METHODS
  There were 125 consecutive patients with ischaemic stroke analysed, who met the inclusion and exclusion criteria. In all patients, -717A>G CRP gene polymorphism was genotyped and analysed in relation to selected stroke risk factors.
  
  
  RESULTS
  Prevalence of type 2 diabetes was lower in patients with AA genotype of -717A>G CRP gene polymorphism than in patients with other alleles (p=0.017). Subjects with GG genotype had significantly higher concentration of CRP comparing to AG genotype (p=0.023). No correlation was found between -717A>G CRP gene polymorphism and the lipid profile and other selected risk factors of stroke.
  
  
  CONCLUSIONS
  In patients with ischaemic stroke in West Pomerania Province, the GG genotype of -717A>G CRP gene polymorphism is associated with significantly higher CRP concentration in relation to AG genotype. Patients with AA genotype may be characterised by lower prevalence of type 2 diabetes.
authors.affiliation: Department of Neurology, Pomeranian Medical University, Szczecin, Poland. Electronic address: dkotlega@poczta.onet.pl.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kotlęga
authors.affiliation: Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Białecka
authors.affiliation: Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Kurzawski
authors.affiliation: Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Droździk
authors.affiliation: Department of Gynaecology and Urogynaecology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Sylwester
authors.initials: S
authors.lastname: Ciećwież
authors.affiliation: Department of Neurology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Gołąb-Janowska
authors.affiliation: Department of Neurology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Nowacki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002545:Brain Ischemia / Q000453:epidemiology* / Q000235:genetics*; D002097:C-Reactive Protein / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002097:C-Reactive Protein; D004247:DNA
keywords: C-reactive protein; Polymorphism; Risk factors; Stroke