title: Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/ β (+) Thalassemia.
abstract: Sickle cell/β (+) thalassemia (Hb S/β (+)thal) is considered as a variant form of sickle cell disease. Acute episodes of vasoocclusive pain crisis are characteristic for sickle cell disorders and may be complicated by an acute or chronic life-threatening organ dysfunction. Chronic intrahepatic cholestasis is a rare and severe complication in sickle cell disease, characterized by marked hyperbilirubinemia and acute hepatic failure with an often fatal course. Despite the fact that patients with Hb S/β (+)thal usually have a mild type of disease, herein we describe an interesting case of chronic intrahepatic cholestasis with successful outcome in an adult patient with Hb S/β (+)thal.
authors.affiliation: Adults Thalassemia Unit, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Konstantinoupoleos 49, 54642 Thessaloniki, Greece.
authors.forename: Efthymia
authors.initials: E
authors.lastname: Vlachaki
authors.affiliation: Adults Thalassemia Unit, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Konstantinoupoleos 49, 54642 Thessaloniki, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Andreadis
authors.affiliation: Adults Thalassemia Unit, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Konstantinoupoleos 49, 54642 Thessaloniki, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Neokleous
authors.affiliation: Adults Thalassemia Unit, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Konstantinoupoleos 49, 54642 Thessaloniki, Greece.
authors.forename: Aleka
authors.initials: A
authors.lastname: Agapidou
authors.affiliation: Adults Thalassemia Unit, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Konstantinoupoleos 49, 54642 Thessaloniki, Greece.
authors.forename: Evaggelia
authors.initials: E
authors.lastname: Vetsiou
authors.affiliation: Department of Gastroenterology, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Konstantinoupoleos 49, 54642 Thessaloniki, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Katsinelos
authors.affiliation: Adults Thalassemia Unit, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Konstantinoupoleos 49, 54642 Thessaloniki, Greece.
authors.forename: Panagiota
authors.initials: P
authors.lastname: Boura