title: FOXO transcription factors: key regulators of cellular quality control.
abstract: FOXO transcription factors are conserved regulators of longevity downstream of insulin signaling. These transcription factors integrate signals emanating from nutrient deprivation and stress stimuli to coordinate programs of genes involved in cellular metabolism and resistance to oxidative stress. Here, we discuss emerging evidence for a pivotal role of FOXO factors in promoting the expression of genes involved in autophagy and the ubiquitin-proteasome system--two cell clearance processes that are essential for maintaining organelle and protein homeostasis (proteostasis). The ability of FOXO to maintain cellular quality control appears to be critical in processes and pathologies where damaged proteins and organelles accumulate, including aging and neurodegenerative diseases.
authors.affiliation: Department of Genetics, Stanford University, Stanford, CA 94305, USA.
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Webb
authors.affiliation: Department of Genetics, Stanford University, Stanford, CA 94305, USA; Glenn Laboratories for the Biology of Aging at Stanford, Stanford, CA 94305, USA. Electronic address: abrunet1@stanford.edu.
authors.forename: Anne
authors.initials: A
authors.lastname: Brunet
mesh_terms: D000375:Aging / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001343:Autophagy; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D046988:Proteasome Endopeptidase Complex; D059748:Proteolysis; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D051858:Forkhead Transcription Factors; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex
keywords: FOXO transcription factors; aging; cellular quality control; proteostasis