title: The synthesis of tenofovir and its analogues via asymmetric transfer hydrogenation.
abstract: A series of tenofovir analogues with potential antiviral and immunobiologically active compounds were synthesized through an asymmetric transfer hydrogenation reaction from achiral purine derivatives. Up to 97% ee and good to excellent yields were achieved under mild conditions through short reaction steps. The present report suggests an efficient process to acquire tenofovir and its analogues.
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University , Xinxiang, Henan 453007, P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Bai-Wei
authors.initials: BW
authors.lastname: Ma
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Wang
authors.forename: Xing-Xing
authors.initials: XX
authors.lastname: Wang
authors.forename: Xia
authors.initials: X
authors.lastname: Hu
authors.forename: Ming-Sheng
authors.initials: MS
authors.lastname: Xie
authors.forename: Gui-Rong
authors.initials: GR
authors.lastname: Qu
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Guo
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006865:Hydrogenation; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000068698:Tenofovir
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D000068698:Tenofovir; D000225:Adenine