title: Primary hepatic sarcomatoid carcinoma: clinical features and prognosis of 28 resected cases.
abstract: OBJECTIVE
  Primary hepatic sarcomatoid carcinoma (SC) is an extremely rare malignancy composed of both carcinomatous and spindle cell sarcomatous components. Our aim was to clarify the clinical features and prognosis of patients with this disease.
  
  
  METHODS
  Between January 1996 and August 2012, 28 patients were histologically diagnosed as primary hepatic SC after surgical resection. Their demographic, clinicopathological, and survival data were retrospectively reviewed.
  
  
  RESULTS
  There were 22 men (78.6 %) and 6 women (21.4 %), with a median age of 53 years (range 29-73 years). The median overall survival was 11.5 months, and the 1-, 2-, and 3-year overall survival rates were 50, 21.4, 14.3 %, respectively. The patients who received radical resection had obviously better survival compared with those underwent palliative resection (15.6 vs. 7.6 months, P = 0.001). Multivariate analysis revealed that TNM stage [HR 8.737, 95 % CI 1.263-60.430, P = 0.042] and local invasion [HR 4.734, 95 % CI 1.382-16.220, P = 0.013] were independent risk factors for overall survival.
  
  
  CONCLUSIONS
  Primary hepatic SC is highly aggressive malignancy with extremely poor prognosis. Radical resection at an early stage may contribute to a relatively favorable prognosis for this uncommon disease.
authors.affiliation: Department of Bile Duct Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Lu
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Xian-Ze
authors.initials: XZ
authors.lastname: Xiong
authors.forename: Fu-Yu
authors.initials: FY
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Ye
authors.forename: Yao
authors.initials: Y
authors.lastname: Cheng
authors.forename: Rong-Xing
authors.initials: RX
authors.lastname: Zhou
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Lin
authors.forename: Nan-Sheng
authors.initials: NS
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002296:Carcinosarcoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor