title: Rates and patterns of macular and circumpapillary retinal nerve fiber layer thinning in preperimetric and perimetric glaucomatous eyes.
abstract: OBJECTIVE
  To evaluate and compare the rates and patterns of macular and circumpapillary retinal nerve fiber layer (cRNFL) thickness thinning, assessed by spectral-domain optical coherence tomography (Cirrus SD-OCT), in eyes with preperimetric (PPG) and perimetric glaucoma (PG).
  
  
  METHODS
  The present retrospective cohort study included 127 eyes of 75 patients (PPG, 87; PG, 40) with a mean follow-up of 2.53 years. All patients underwent at least 4 SD-OCT examinations. Linear mixed effects models were used to evaluate the rates of changes in relevant cRNFL and macular parameters.
  
  
  RESULTS
  Overall, after adjusting for covariates including age, baseline OCT data, and visual field severity, thickness changes in the 6 o'clock (-2.325 μm/y, cRNFL) and inferior outer sector (-2.879 μm/y, macular) showed the highest progression rates among all evaluated parameters. When -0.26 and -0.42 μm/y in average cRNFL and macular thickness changes were used as reference values for age-related physiological loss, 64.4% and 80.5% of PPG eyes and 60% and 70% of PG eyes, respectively, showed higher progression rates than these values. PG eyes showed significantly higher progression rates in the fovea and the inferior inner sector of the macula than did PPG eyes, although no progression rate of any cRNFL parameter differed between the 2 groups.
  
  
  CONCLUSIONS
  PG and PPG eyes showed different rates and patterns in macular thickness progression when assessed by Cirrus SD-OCT.
authors.affiliation: Departments of *Ophthalmology ‡Clinical Epidemiology and Biostatistics, Asan Medical Center, College of Medicine, University of Ulsan †Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University, Seoul, Korea.
authors.forename: Jung Hwa
authors.initials: JH
authors.lastname: Na
authors.forename: Kyung Rim
authors.initials: KR
authors.lastname: Sung
authors.forename: Seung Hee
authors.initials: SH
authors.lastname: Baek
authors.forename: Soon Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Kilwhan
authors.initials: K
authors.lastname: Shon
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Jung
mesh_terms: D015331:Cohort Studies; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology