title: Nanoparticles for imaging, sensing, and therapeutic intervention.
abstract: Nanoparticles have the potential to contribute to new modalities in molecular imaging and sensing as well as in therapeutic interventions. In this Nano Focus article, we identify some of the current challenges and knowledge gaps that need to be confronted to accelerate the developments of various applications. Using specific examples, we journey from the characterization of these complex hybrid nanomaterials; continue with surface design and (bio)physicochemical properties, their fate in biological media and cells, and their potential for cancer treatment; and finally reflect on the role of animal models to predict their behavior in humans.
authors.affiliation: Department of Biochemistry, Institute of Integrative Biology, University of Liverpool , Liverpool, Merseyside L69 3BX, United Kingdom.
authors.forename: Lara K
authors.initials: LK
authors.lastname: Bogart
authors.forename: Genevieve
authors.initials: G
authors.lastname: Pourroy
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Murphy
authors.forename: Victor
authors.initials: V
authors.lastname: Puntes
authors.forename: Teresa
authors.initials: T
authors.lastname: Pellegrino
authors.forename: Daniel
authors.initials: D
authors.lastname: Rosenblum
authors.forename: Dan
authors.initials: D
authors.lastname: Peer
authors.forename: Raphaël
authors.initials: R
authors.lastname: Lévy
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D001672:Biocompatible Materials