title: The emerging role of MMP14 in brain tumorigenesis and future therapeutics.
abstract: Glioblastoma is a malignant brain tumor of glial origin. These tumors are thought to be derived from astrocytic cells that undergo malignant transformation. A growing body of evidence suggests that upregulation of MMP expression plays a significant role in promoting glioma pathogenesis. Elevated expression of MMP14 not only promotes glioma invasion and tumor cell proliferation but also plays a role in angiogenesis. Despite the fact that levels of MMP14 correlate with breast cancer progression, the controversial role of MMP14 in gliomagenesis needs to be elucidated. In the present review, we discuss the role of MMP14 in glioma progression as well as the mechanisms of MMP14 regulation in the context of future therapeutic manipulations.
authors.affiliation: Ivy Brain Tumor Center, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
authors.forename: Ilya
authors.initials: I
authors.lastname: Ulasov
authors.affiliation: Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.
authors.forename: Ruiyang
authors.initials: R
authors.lastname: Yi
authors.affiliation: Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.
authors.forename: Donna
authors.initials: D
authors.lastname: Guo
authors.affiliation: Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.
authors.forename: Purvaba
authors.initials: P
authors.lastname: Sarvaiya
authors.affiliation: Ivy Brain Tumor Center, Swedish Neuroscience Institute, Seattle, WA 98122, USA. Electronic address: charles.cobbs@gmail.com.
authors.forename: Charles
authors.initials: C
authors.lastname: Cobbs
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism; D005909:Glioblastoma / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D053511:Matrix Metalloproteinase 14 / Q000235:genetics / Q000502:physiology*; D058990:Molecular Targeted Therapy; D023041:Xenograft Model Antitumor Assays
chemical_list: C507086:MMP14 protein, human; D053511:Matrix Metalloproteinase 14
keywords: Angiogenesis; Brain; Glioblastoma; Invasion; MMP14; Tumor