title: In vitro and in vivo antitumor evaluation of berbamine for lung cancer treatment.
abstract: OBJECTIVE
  Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers.
  
  
  METHODS
  In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts.
  
  
  RESULTS
  Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time.
  
  
  CONCLUSIONS
  Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.
authors.affiliation: First Department of Respiratory Medicine, Nanjing Chest Hospital and Clinical Center of Nanjing Respiratory Diseases, Nanjing, China E-mail : huangxinen06@aliyun.com, baxia1108@126.com.
authors.forename: Zhi-Bo
authors.initials: ZB
authors.lastname: Hou
authors.forename: Kai-Jin
authors.initials: KJ
authors.lastname: Lu
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Wu
authors.forename: Cong
authors.initials: C
authors.lastname: Chen
authors.forename: Xin-En
authors.initials: XE
authors.lastname: Huang
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Yin
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D044182:Benzylisoquinolines / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D051379:Mice; D008819:Mice, Nude; D014183:Transplantation, Heterologous; D023041:Xenograft Model Antitumor Assays
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers; C027870:berbamine