title: Polymorphisms ofSTAT4and the risk of inflammatory bowel disease: A case-control study in Chinese Han population.
abstract: Signal transducer and activator of transcription 4 (STAT4) is a transcription factor involved in the signaling pathways of several cytokines, playing an essential role in the development of inflammation in various immune-mediated diseases. Genetic association studies have shown that theSTAT4gene was significantly associated with inflammatory bowel disease (IBD) in Spanish and Caucasian populations. However, these associations in other ethnic populations remain unknown. In the present study, we evaluated the role of theSTAT4rs7574865 and rs7582694 polymorphisms on IBD in 562 unrelated Chinese Han subjects by assessing distributions of genotypes and allele frequencies. Results showed that neither rs7574865 [Crohn's disease (CD): P=0.66, odds ratio (OR) = 0.95, 95% confidence interval (CI) 0.74-1.21; ulcerative colitis (UC): P=0.43, OR=0.85, 95% CI 0.56-1.28; IBD: P=0.52, OR=0.93, 95% CI 0.73-1.17] nor rs7582694 (CD: P=0.40, OR=1.12, 95% CI 0.86-1.44; UC: P=0.50, OR=0.86, 95% CI 0.56-1.33; IBD: P=0.62, OR=1.06, 95% CI 0.83-1.36) was significantly associated with IBD, although the genotype frequency of rs7574865 varied in patients and the controls. In conclusion, our data did not support thatSTAT4variants contribute to IBD susceptibility in the Chinese Han population.
authors.affiliation: Department of Medical Genetics, E-Institutes of Shanghai Universities, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China ;
authors.forename: Houbao
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Medical Genetics, E-Institutes of Shanghai Universities, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China ;
authors.forename: Jianbing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Research Center for Experimental Medicine, State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Shanghai, P.R. China ;
authors.forename: Hongxin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Shanghai, P.R. China ;
authors.forename: Zhengting
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Orthopaedics and Traumatology, Department of Orthopaedics, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Research Center for Experimental Medicine, State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Shanghai, P.R. China ;
authors.forename: Shunyuan
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of Medical Genetics, E-Institutes of Shanghai Universities, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China ;
authors.forename: Wangyang
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, Shanghai, P.R. China ;
authors.forename: Jie
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Department of Medical Genetics, E-Institutes of Shanghai Universities, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China ; ; Research Center for Experimental Medicine, State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Shanghai, P.R. China ; ; Shanghai Research Center for Model Organisms, Shanghai, P.R. China.
authors.forename: Zhugang
authors.initials: Z
authors.lastname: Wang
keywords: Chinese Han population; inflammatory bowel disease; signal transducer and activator of transcription 4; single-nucleotide polymorphisms