title: The mystery of aging and rejuvenation - a budding topic.
abstract: In the process of yeast budding, an aged and deteriorated mother cell gives rise to a youthful and pristine daughter cell. This remarkable event offers a tractable model system for identifying factors affecting life expectancy and it has been established that multiple aging factors operate in parallel. Herein, we will highlight the identity of such aging factors, how they are asymmetrically segregated, and whether the knowledge of their deteriorating effects might be utilized to approach cellular and tissue rejuvenation in metazoans, including humans.
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, Medicinaregatan 9C, S-413 90 Göteborg, Sweden. Electronic address: thomas.nystrom@cmb.gu.se.
authors.forename: Thomas
authors.initials: T
authors.lastname: Nyström
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, Medicinaregatan 9C, S-413 90 Göteborg, Sweden.
authors.forename: Beidong
authors.initials: B
authors.lastname: Liu
mesh_terms: D002455:Cell Division; D008954:Models, Biological; D004718:Saccharomycetales / Q000166:cytology* / Q000502:physiology*