title: Enantio- and chemoselective Brønsted-acid/Mg(nBu)2 catalysed reduction of α-keto esters with catecholborane.
abstract: The first enantio- and chemoselective Brønsted-acid catalysed reduction of α-keto esters with catecholborane has been developed. The α-hydroxy esters were obtained under mild reaction conditions in virtually quantitative yields and excellent enantioselectivities. With slight modifications both enantiomers can be obtained without any loss of selectivity.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany. enders@rwth-aachen.de.
authors.forename: Dieter
authors.initials: D
authors.lastname: Enders
authors.forename: Bianca A
authors.initials: BA
authors.lastname: Stöckel
authors.forename: Andreas
authors.initials: A
authors.lastname: Rembiak
mesh_terms: D000143:Acids / Q000737:chemistry*; D001880:Boranes / Q000737:chemistry*; D002384:Catalysis; D002396:Catechols / Q000737:chemistry; D004952:Esters; D008670:Metals / Q000737:chemistry; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000143:Acids; D001880:Boranes; D002396:Catechols; D004952:Esters; D008670:Metals; C034221:catechol