title: Dermatomyositis associated with hepatitis B virus-related hepatocellular carcinoma.
abstract: Dermatomyositis is an idiopathic inflammatory myopathy with typical cutaneous manifestations. It has been proposed that dermatomyositis may be caused by autoimmune responses to viral infections. Previous studies have shown an association between dermatomyositis and malignant tumors such as ovarian cancer, lung cancer, and colorectal cancer. However, a chronic hepatitis B virus (HBV) infection associated with dermatomyositis and hepatocellular carcinoma (HCC) has been very rarely reported. Here, we report a rare case of dermatomyositis coinciding with HBV-associated HCC. A 55-year-old male was confirmed to have HCC and dermatomyositis based on proximal muscle weakness, typical skin manifestations, elevated muscle enzyme levels, and muscle biopsy findings. This case suggests that HCC and/or a chronic HBV infection may be factors in the pathogenesis of dermatomyositis through a paraneoplastic mechanism.
authors.affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Suh Yoon
authors.initials: SY
authors.lastname: Yang
authors.affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Bong Ki
authors.initials: BK
authors.lastname: Cha
authors.affiliation: Department of Radiology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Gihyeon
authors.initials: G
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Hyun Woong
authors.initials: HW
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Jae Gyu
authors.initials: JG
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Sae Kyung
authors.initials: SK
authors.lastname: Chang
authors.affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000821:virology*; D003882:Dermatomyositis / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D018450:Disease Progression; D017809:Fatal Outcome; D005938:Glucocorticoids / Q000627:therapeutic use; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000821:virology*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D012307:Risk Factors; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D005938:Glucocorticoids
keywords: Dermatomyositis; Hepatitis B virus; Hepatocellular carcinoma