title: Spectinamides: a challenge, a proof, and a suggestion.
abstract: New drugs and shorter regimens are needed to fight resistant forms of tuberculosis. Screening of chemical libraries for mining hit compounds is the common approach to find new antituberculars. A new medicinal chemistry and biology directed research rational has recently been successfully described by Lee and coworkers in Nature Medicine.
authors.affiliation: Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisboa, Portugal. Electronic address: mviveiros@ihmt.unl.pt.
authors.forename: Miguel
authors.initials: M
authors.lastname: Viveiros
authors.affiliation: Dipartimento di Farmacia, Centro Interdipartimentale BIOPHARMANET_TEC, Università di Parma, Parco Area delle Scienze 27, 43124 Parma, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Pieroni
mesh_terms: D000577:Amides / Q000494:pharmacology*; D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D015195:Drug Design; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D000198:Spectinomycin / Q000494:pharmacology*; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*
chemical_list: D000577:Amides; D000995:Antitubercular Agents; D000198:Spectinomycin