title: Successful cognitive aging and health-related quality of life in younger and older adults infected with HIV.
abstract: Neurocognitive impairments commonly occur and adversely impact everyday functioning in older adults infected with HIV, but little is known about successful cognitive aging (SCA) and its health-related quality of life (HRQoL) correlates. Seventy younger (≤40 years) and 107 older (≥50 years) HIV+ adults, as well as age-matched seronegative comparison groups of younger (N = 48) and older (N = 77) subjects completed a comprehensive battery of neuropsychological, psychiatric, medical, and HRQoL assessments. SCA was operationalized as the absence of both performance-based neurocognitive deficits and self-reported symptoms (SCA-ANDS) as determined by published normative standards. A stair-step decline in SCA-ANDS was observed in accordance with increasing age and HIV serostatus, with the lowest rates of SCA-ANDS found in the older HIV+ group (19 %). In both younger and older HIV+ adults, SCA-ANDS was strongly related to better mental HRQoL. HIV infection has additive adverse effects on SCA, which may play a unique role in mental well-being among HIV-infected persons across the lifespan.
authors.affiliation: Department of Psychiatry (8231), University of California, San Diego, 220 Dickinson St., Suite B, San Diego, CA, 92103, USA, r6moore@ucsd.edu.
authors.forename: Raeanne C
authors.initials: RC
authors.lastname: Moore
authors.forename: Pariya L
authors.initials: PL
authors.lastname: Fazeli
authors.forename: Dilip V
authors.initials: DV
authors.lastname: Jeste
authors.forename: David J
authors.initials: DJ
authors.lastname: Moore
authors.forename: Igor
authors.initials: I
authors.lastname: Grant
authors.forename: Steven Paul
authors.initials: SP
authors.lastname: Woods
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000328:Adult; D000368:Aged; D000375:Aging / Q000523:psychology; D003071:Cognition; D003072:Cognition Disorders / Q000523:psychology*; D003863:Depression / Q000523:psychology; D005260:Female; D006679:HIV Seropositivity / Q000523:psychology*; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011788:Quality of Life; D019966:Substance-Related Disorders / Q000503:physiopathology / Q000523:psychology