title: Three-port operation in three-zone simulated moving bed chromatography.
abstract: A new operating method, namely three-port operation in a three-zone simulated moving bed (TT-SMB), was developed to improve the separation performance of simulated moving bed (SMB) chromatography. In the TT-SMB, the switching period consists of two steps; extract outlet port is closed at the first step for raffinate production and raffinate outlet port is closed at the second step for extract production. As a result, three ports were used in each step of the three-zone SMB operation. The separation performance of TT-SMB was compared with conventional three- and four-zone SMBs in terms of purity, recovery, productivity, and eluent consumption. A conventional three-zone SMB operation usually produced the contaminated portion at the product outlet node during the switching period. However, such phenomenon could be prevented by using the TT-SMB operation because one product outlet port was closed at each step. Compared to the conventional three-zone SMB, all performance parameters improved with the use of TT-SMB, and the improvement in purity and recovery was significant (up to 7%). Adjusting the step ratio played a key role in the trade-off between the performance parameters. The purity, recovery, and productivity of TT-SMB at well-designed step ratio conditions are up to 3% higher than those of the conventional four-zone methods (1-1-1-1 configuration).
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro Seodaemun-gu, Seoul, 120-749, South Korea; Business Innovation Center (BIC), SK Gas, SK G. Plant, 100 Eulji-ro, Jung-gu, Seoul, 100-192, South Korea.
authors.forename: Kyung-Min
authors.initials: KM
authors.lastname: Kim
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro Seodaemun-gu, Seoul, 120-749, South Korea.
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Song
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro Seodaemun-gu, Seoul, 120-749, South Korea. Electronic address: leech@yonsei.ac.kr.
authors.forename: Chang-Ha
authors.initials: CH
authors.lastname: Lee
mesh_terms: D002845:Chromatography / Q000379:methods*; D008956:Models, Chemical
keywords: Simulated moving bed (SMB); Three-port operation in three-zone simulated moving bed (TT-SMB); Three-zone SMB