title: [Central motor pathways in children with multiple sclerosis].
abstract: OBJECTIVE
  To evaluate motor pathways involvement in children with multiple sclerosis.
  
  
  METHODS
  We used transcranial magnetic stimulation method. 9 children with relapsing-remitting multiple sclerosis (mean duration 1,68 years) and 20 controls were enrolled.
  
  
  RESULTS
  In most of the cases findings in multiple sclerosis group were abnormal. More often polyphasic changes of the motor evoked potentials (MEP) shape (78% of the cases) and elevation of MEP threshold (88%) were seen.
  
  
  CONCLUSIONS
  Transcranial magnetic stimulation demonstrated high sensitivity in children with multiple sclerosis. Main neurophysiologic findings in multiple sclerosis in children may reflect altering membrane excitability of motor neurons and demyelinating lesions. Axonal damage in children with multiple sclerosis are less apparent.
authors.forename: V B
authors.initials: VB
authors.lastname: Voĭtenkov
authors.forename: V N
authors.initials: VN
authors.lastname: Komantsev
authors.forename: N V
authors.initials: NV
authors.lastname: Skripchenko
authors.forename: G P
authors.initials: GP
authors.lastname: Ivanova
authors.forename: A V
authors.initials: AV
authors.lastname: Surovtseva
authors.forename: A V
authors.initials: AV
authors.lastname: Klimkin
mesh_terms: D000293:Adolescent; D004525:Efferent Pathways / Q000503:physiopathology*; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000502:physiology*; D009103:Multiple Sclerosis / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation