title: Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer's disease.
abstract: OBJECTIVE
  To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI).
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  Community-based memory clinic.
  
  
  METHODS
  Individuals meeting Petersen's MCI criteria (N = 165).
  
  
  METHODS
  Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA-TS, MoCA-MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD.
  
  
  RESULTS
  One hundred fourteen participants progressed to AD (MCI-AD), and 51 did not (nonconverters; MCI-NC); 90.5% of participants with MCI with a MoCA-TS less than 20/30 and a MoCA-MIS less than 7/15 at baseline converted to AD within the average follow-up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple-domain amnestic MCI had the highest AD conversion rates (73.9%).
  
  
  CONCLUSIONS
  Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA-TS and a low newly devised memory index score (MoCA-MIS) are at greater risk of short-term conversion to AD.
authors.affiliation: Center for Diagnosis and Research on Alzheimer's Disease, Greenfield Park, Quebec, Canada; Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Parunyou
authors.initials: P
authors.lastname: Julayanont
authors.forename: Mélanie
authors.initials: M
authors.lastname: Brousseau
authors.forename: Howard
authors.initials: H
authors.lastname: Chertkow
authors.forename: Natalie
authors.initials: N
authors.lastname: Phillips
authors.forename: Ziad S
authors.initials: ZS
authors.lastname: Nasreddine
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D003071:Cognition / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D015577:Geriatric Assessment / Q000379:methods*; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011379:Prognosis; D011792:Quebec / Q000453:epidemiology; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed
keywords: Alzheimer; Memory Index Score; Montreal Cognitive Assessment; mild cognitive impairment