title: [Stevens-Johnson syndrome and toxic epidermal necrolysis].
abstract: Stevens-Johnson syndrome and toxic epidermal necrolysis are acute mucocutaneous diseases primarily due to drug intake. The diseases are characterised by the separation of epidermis from dermis which can be life-threatening. Mortality is often caused by sepsis and multiple organ failure. The most common drugs involved are antibiotics, antiepileptic medicine, allopurinol and nonsteroidal anti-inflammatory drugs. Besides withdrawing the suspected drug the treatment is mainly symptomatic. A number of systemic treatments have been suggested including systemic corticosteroids, intravenous immunoglobulins, cyclosporine, granulocyte colony stimulating factor and tumour necrosis factor-alpha inhibitors although they remain controversial.
authors.affiliation: Hud- og allergiafdelingen, Gentofte Hospital, Niels Andersens Vej 65, 2900 Hellerup. diljit.kaur@regionh.dk
authors.forename: Diljit
authors.initials: D
authors.lastname: Kaur-Knudsen
authors.forename: Claus
authors.initials: C
authors.lastname: Zachariae
authors.forename: Simon Francis
authors.initials: SF
authors.lastname: Thomsen
mesh_terms: D006801:Humans; D012867:Skin / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology