title: Modelling hormonal response and development.
abstract: As our knowledge of the complexity of hormone homeostasis, transport, perception, and response increases, and their outputs become less intuitive, modelling is set to become more important. Initial modelling efforts have focused on hormone transport and response pathways. However, we now need to move beyond the network scales and use multicellular and multiscale modelling approaches to predict emergent properties at different scales. Here we review some examples where such approaches have been successful, for example, auxin-cytokinin crosstalk regulating root vascular development or a study of lateral root emergence where an iterative cycle of modelling and experiments lead to the identification of an overlooked role for PIN3. Finally, we discuss some of the remaining biological and technical challenges.
authors.affiliation: Centre for Plant Integrative Biology, University of Nottingham, Nottingham, LE12 5RD, UK.
authors.forename: Ute
authors.initials: U
authors.lastname: Voß
authors.affiliation: Centre for Plant Integrative Biology, University of Nottingham, Nottingham, LE12 5RD, UK.
authors.forename: Anthony
authors.initials: A
authors.lastname: Bishopp
authors.affiliation: Centre for Plant Integrative Biology, University of Nottingham, Nottingham, LE12 5RD, UK; School of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
authors.forename: Etienne
authors.initials: E
authors.lastname: Farcot
authors.affiliation: Centre for Plant Integrative Biology, University of Nottingham, Nottingham, LE12 5RD, UK. Electronic address: malcolm.bennett@nottingham.ac.uk.
authors.forename: Malcolm J
authors.initials: MJ
authors.lastname: Bennett
mesh_terms: D001692:Biological Transport; D018506:Gene Expression Regulation, Plant; D008954:Models, Biological; D063245:Plant Development / Q000502:physiology*; D010937:Plant Growth Regulators / Q000378:metabolism*; D018517:Plant Roots / Q000254:growth & development / Q000502:physiology; D018520:Plant Shoots / Q000254:growth & development / Q000502:physiology; D010944:Plants / Q000235:genetics; D015398:Signal Transduction; D049490:Systems Biology
chemical_list: D010937:Plant Growth Regulators
keywords: hormone signalling; modelling; multiscale modelling; systems biology