title: Systemic vascular inflammation in abdominal aortic aneurysm patients: a contrast-enhanced PET/CT study.
abstract: OBJECTIVE
  The aim of this paper was to investigate the presence of systemic vascular inflammation and its relationship with risk factors and biomarkers of systemic inflammation related to atherosclerosis in asymptomatic abdominal aortic aneurysm (AAA) patients.
  
  
  METHODS
  Thirty AAA patients and 30 age-matched controls underwent contrast-enhanced 2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET/CT. C-reactive protein, erythrocyte sedimentation rate, white blood cell count and differential, serum fibrinogen, D-dimer and full lipid panel were also evaluated. Region of interest analyses were performed to obtain target-to-background (TBR) metabolism of aorta, subclavian, carotid, iliac arteries and AAA. CT-based arterial calcium load (CL) was evaluated. Arterial Metabolism and CL intergroup differences were tested (unpaired t-test). Linear regression analysis was performed only between blood biomarkers on one side and both TBR and ACL of the arterial districts that resulted significantly different between patients and controls on the other. In all the analyses P values <0.05 were considered significant.
  
  
  RESULTS
  FDG-uptake was higher with respect to controls in aorta, carotid and iliac arteries (P<0.01, P<0.007, P<0.04 respectively). AAA and aorta metabolism showed an inverse correlation with HDL-chol (P<0.02 and P<0.01, respectively) while only aorta showed a direct correlation with lymphocytes' count (P<0.02). Carotid metabolism was directly correlated with monocytes' count and C-reactive protein concentration (P<0.02 and P<0.004, respectively).
  
  
  CONCLUSIONS
  The present findings support the relevance of systemic vascular inflammation in all phases of atherosclerosis-related disorders. Moreover they confirm the concept that acute ischemic syndromes might represent the local result of a systemic inflammation rather than the focal involvement of a single arterial lesion.
authors.affiliation: Nuclear Medicine Unit IRCCS San Martino University Hospital, IST Dept of Health Sciences, University of Genoa, Genoa, Italy - silviadaniela.morbelli@hsanmartino.it.
authors.forename: S
authors.initials: S
authors.lastname: Morbelli
authors.forename: G
authors.initials: G
authors.lastname: Ghigliotti
authors.forename: G
authors.initials: G
authors.lastname: Spinella
authors.forename: C
authors.initials: C
authors.lastname: Marini
authors.forename: I
authors.initials: I
authors.lastname: Bossert
authors.forename: M
authors.initials: M
authors.lastname: Cimmino
authors.forename: B
authors.initials: B
authors.lastname: Pane
authors.forename: N
authors.initials: N
authors.lastname: Rousas
authors.forename: G
authors.initials: G
authors.lastname: Cittadini
authors.forename: M
authors.initials: M
authors.lastname: Massollo
authors.forename: D
authors.initials: D
authors.lastname: Camellino
authors.forename: M
authors.initials: M
authors.lastname: Riondato
authors.forename: D
authors.initials: D
authors.lastname: Palombo
authors.forename: C
authors.initials: C
authors.lastname: Barisione
authors.forename: G
authors.initials: G
authors.lastname: Sambuceti
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D003287:Contrast Media; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D056647:Systemic Vasculitis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18