title: Supra-amphiphilic aggregates formed by p-sulfonatocalix[4]arenes and the antipsychotic drug chlorpromazine.
abstract: We report here a supramolecular strategy to directly assemble the small molecular antipsychotic drug chlorpromazine (CPZ) into nanostructures, induced by p-sulfonatocalix[4]arene (SC4A) and p-sulfonatocalix[4]arene tetraheptyl ether (SC4AH), with high drug loading efficiencies of 61% and 46%, respectively. The binary host-guest assembly process was monitored using optical transmittance measurements, and the size and morphology of these two kinds of supra-amphiphilic assemblies were identified using a combination of light scattering and high-resolution transmission electron microscopy, which showed solid spherical micelles. This strategy presents new opportunities for the development of high loading drug-containing carriers with easy processability for drug delivery.
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, P. R. China. yuliu@nankai.edu.cn.
authors.forename: Zhanbin
authors.initials: Z
authors.lastname: Qin
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Guo
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Gao
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D014150:Antipsychotic Agents / Q000737:chemistry*; D047250:Calixarenes / Q000138:chemical synthesis / Q000737:chemistry*; D002746:Chlorpromazine / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D014150:Antipsychotic Agents; D004337:Drug Carriers; D008823:Micelles; D010636:Phenols; C121325:calix(4)arene; D014867:Water; D047250:Calixarenes; D002746:Chlorpromazine