title: Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post-infarcted cardiac function in rats.
abstract: The midterm effects of cardiac telocytes (CTs) transplantation on myocardial infarction (MI) and the cellular mechanisms involved in the beneficial effects of CTs transplantation are not understood. In the present study, we have revealed that transplantation of CTs was able to significantly decrease the infarct size and improved cardiac function 14 weeks after MI. It has established that CT transplantation exerted a protective effect on the myocardium and this was maintained for at least 14 weeks. The cellular mechanism behind this beneficial effect on MI was partially attributed to increased cardiac angiogenesis, improved reconstruction of the CT network and decreased myocardial fibrosis. These combined effects decreased the infarct size, improved the reconstruction of the LV and enhanced myocardial function in MI. Our findings suggest that CTs could be considered as a potential cell source for therapeutic use to improve cardiac repair and function following MI, used either alone or in tandem with stem cells.
authors.affiliation: Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China; Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China; International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China; Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China.
authors.forename: Baoyin
authors.initials: B
authors.lastname: Zhao
authors.forename: Zhaofu
authors.initials: Z
authors.lastname: Liao
authors.forename: Shang
authors.initials: S
authors.lastname: Chen
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Yuan
authors.forename: Chen
authors.initials: C
authors.lastname: Yilin
authors.forename: Kenneth K H
authors.initials: KK
authors.lastname: Lee
authors.forename: Xufeng
authors.initials: X
authors.lastname: Qi
authors.forename: Xiaotao
authors.initials: X
authors.lastname: Shen
authors.forename: Xin
authors.initials: X
authors.lastname: Zheng
authors.forename: Thomas
authors.initials: T
authors.lastname: Quinn
authors.forename: Dongqing
authors.initials: D
authors.lastname: Cai
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D005260:Female; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D056885:Interstitial Cells of Cajal / Q000637:transplantation*; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D009206:Myocardium / Q000473:pathology*; D018919:Neovascularization, Physiologic; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D033581:Stem Cell Transplantation
chemical_list: D018952:Antigens, CD34; D003094:Collagen; D019009:Proto-Oncogene Proteins c-kit
keywords: cardiac telocytes; myocardial infarction; post-infarction cardiac function