title: [Dengue virus serotype 1 (DENV-1) from Colombia: its contribution to dengue occurrence in Santander].
abstract: BACKGROUND
  Between 1998 and 2008 all dengue virus serotypes circulated in the Departamento de Santander, an endemic region in northeastern Colombia. No information is available as to the role of serotype 1 (DENV-1) with respect to epidemiology of dengue.
  
  
  OBJECTIVE
  To analyze the relationship between changes in DENV-1 predominance with respect to genetic diversity, prevalence of others serotypes and occurrence of severe dengue.
  
  
  METHODS
  Virus genetic diversity was studied by phylogenetic analysis comparing E gene sequences from 12 viral strains. Data about serotypes predominance obtained in previous studies and official data about dengue incidence were used for analysis.
  
  
  RESULTS
  Selected viruses grouped into genotype V together DENV-1 from Latin America countries, and segregation in four lineages was evidenced. Changes in virus predominance coincided with replacement of lineage, increase in prevalence of DENV-2 and DENV-3 and increase of severe dengue.
  
  
  CONCLUSIONS
  Genetic divergence could have contributed to changes in DENV-1 predominance. The relationship of the virus with DENV-2 and DENV-3 could create scenarios that promote occurrence of severe cases. More studies are required to ascertain the precise role of serotypes in the epidemiology of dengue.
authors.affiliation: Laboratorio de Arbovirus, Centro de Investigaciones en Enfermedades Tropicales, Universidad Industrial de Santander, Bucaramanga, Colombia.
authors.forename: Raquel E
authors.initials: RE
authors.lastname: Ocazionez-Jiménez
authors.affiliation: Laboratorio de Sistemática y Biogeografía, Escuela de Biología, Universidad Industrial de Santander.
authors.forename: Ayda Susana
authors.initials: AS
authors.lastname: Ortiz-Báez
authors.affiliation: Laboratorio de Arbovirus, Centro de Investigaciones en Enfermedades Tropicales, Universidad Industrial de Santander, Bucaramanga, Colombia.
authors.forename: Sergio Yebrail
authors.initials: SY
authors.lastname: Gómez-Rangel
authors.affiliation: Laboratorio de Sistemática y Biogeografía, Escuela de Biología, Universidad Industrial de Santander.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Miranda-Esquivel
mesh_terms: D003105:Colombia / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology / Q000821:virology*; D003716:Dengue Virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D004196:Disease Outbreaks; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015994:Incidence; D010802:Phylogeny; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D065288:Serogroup; D012703:Serotyping; D019595:Severe Dengue / Q000453:epidemiology / Q000821:virology; D014759:Viral Envelope Proteins / Q000235:genetics / Q000502:physiology; D014774:Virulence
chemical_list: D012367:RNA, Viral; D014759:Viral Envelope Proteins; C072281:E protein TH Sman, Dengue virus