title: Effects of age, gender and region on serum concentrations of perfluorinated compounds in general population of Henan, China.
abstract: 133 Serum samples collected from Henan donors aged from 0 to 88years were analyzed for 12 perfluorinated compounds (PFCs). Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) accounted for 69.19% of the total PFCs in serum samples, with a median concentration of 1.43 and 1.47ngmL(-)(1), respectively. Other PFCs were detected at much lower concentrations, with median concentrations ranging from 0.03 to 0.37ngmL(-)(1). PFOA and PFOS were positively correlated (r=0.219) in serum samples, indicating that they may have common exposure pathways. For all donors (0-88years), significant increases in PFOA (r=0.239, p<0.01), perfluorononanoic acid (PFNA) (r=0.185, p<0.05) and PFOS (r=0.175, p<0.05) concentrations over age were found. Median concentrations of PFOA, PFNA, perfluorodecanoic acid (PFDA), and PFOS were higher in males than in females. Higher PFOA concentrations were found in urban populations than in rural populations. Since PFCs exposure in general population is prevalent, further studies are needed to explore its possible impacts on epidemiological factors.
authors.affiliation: State Key Lab of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Yaning
authors.initials: Y
authors.lastname: Fu
authors.affiliation: State Key Lab of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
authors.forename: Tieyu
authors.initials: T
authors.lastname: Wang
authors.affiliation: State Key Lab of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Wang
authors.affiliation: Red Cross Hospital of Yuanyang, Yuanyang County, Henan 453500, China.
authors.forename: Quanliang
authors.initials: Q
authors.lastname: Fu
authors.affiliation: State Key Lab of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address: yllu@rcees.ac.cn.
authors.forename: Yonglong
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017738:Alkanesulfonic Acids / Q000097:blood*; D002210:Caprylates / Q000097:blood*; D002675:Child, Preschool; D002681:China; D003652:Decanoic Acids / Q000097:blood*; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014505:Urban Population; D055815:Young Adult
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D003652:Decanoic Acids; D004785:Environmental Pollutants; D005466:Fluorocarbons; C036567:perfluorodecanoic acid; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid
keywords: General population; Henan; Perfluorinated compound; Serum