title: Cerebrospinal fluid IL-1β correlates with cortical pathology load in multiple sclerosis at clinical onset.
abstract: The cerebrospinal fluid levels of interleukin-1 beta and structural magnetic resonance parameters of cortical damage, i.e., cortical lesion number and volume, and global cortical thickness, were analysed in multiple sclerosis patients at clinical onset. Cerebrospinal fluid interleukin-1 beta levels strongly correlated with cortical lesion load and cortical thickness, while correlation with white matter lesion load was modest. Interleukin-1 beta, intrathecally produced by infiltrating lymphocytes and activated microglia, may constitute a possible link between inflammation and neurodegeneration in multiple sclerosis.
authors.affiliation: Multiple Sclerosis Centre of Padova, Department of Neurosciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Seppi
authors.affiliation: Multiple Sclerosis Centre of Padova, Department of Neurosciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Puthenparampil
authors.affiliation: Multiple Sclerosis Centre of Padova, Department of Neurosciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
authors.forename: Lisa
authors.initials: L
authors.lastname: Federle
authors.affiliation: Neurosciences Laboratory, First Neurology Clinic, Department of Neurosciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Ruggero
authors.affiliation: Neurosciences Laboratory, First Neurology Clinic, Department of Neurosciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Toffanin
authors.affiliation: Multiple Sclerosis Centre of Padova, Department of Neurosciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Rinaldi
authors.affiliation: Multiple Sclerosis Centre of Padova, Department of Neurosciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Perini
authors.affiliation: Multiple Sclerosis Centre of Padova, Department of Neurosciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy. Electronic address: paolo.gallo@unipd.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Gallo
mesh_terms: D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000134:cerebrospinal fluid*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000473:pathology*; D055815:Young Adult
chemical_list: D053583:Interleukin-1beta
keywords: Cortical pathology; Interleukin-1β; Multiple sclerosis