title: Biocatalytic synthesis of optically active hydroxyesters via lipase-catalyzed decarboxylative aldol reaction and kinetic resolution.
abstract: A two-step sequential biocatalytic process for the synthesis of chiral hydroxyesters that combines a lipase-catalyzed decarboxylative aldol reaction followed by kinetic resolution has been developed. The excellent combination of conventional and unconventional functions provides an attractive route for expanding the applications of biocatalysis.
authors.affiliation: Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, People's Republic of China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Zhang
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.forename: Xing-Wen
authors.initials: XW
authors.lastname: Feng
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Yu
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology; D055162:Biocatalysis; D002175:Candida / Q000201:enzymology; D002264:Carboxylic Acids / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D004952:Esters; D007659:Ketones / Q000737:chemistry*; D007700:Kinetics; D008049:Lipase / Q000378:metabolism*; D055620:Optical Phenomena; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D002264:Carboxylic Acids; D004952:Esters; D007659:Ketones; D008049:Lipase