title: Mini-fasting tests diagnosing endogenous hyperinsulinism: a follow-up of 26 cases.
abstract: BACKGROUND
  The supervised 72-h fast remains the gold standard test for the diagnosis of endogenous hyperinsulinism and has recently been suggested to be shortened or even avoided.
  
  
  OBJECTIVE
  This study aimed to evaluate whether measurement of blood glucose, insulin and C-peptide levels after a 12 h overnight fast (mini-fasting test), in at least 3 consecutive days, could allow making or ruling out diagnosis of endogenous hyperinsulinism, according to the Endocrine Society's recent guidelines.
  
  
  METHODS
  We performed 12 h mini-fasting test in at least 3 consecutive days, dosing blood glucose, insulin and C-peptide levels in 26 inpatient patients with pathologically proven endogenous hyperinsulinism.
  
  
  RESULTS
  In our series, 100% of patients showed insulin levels of at least 3 μU/ml and C-peptide levels of at least 0.6 ng/ml concomitant with symptomatic hypoglycemia (≤ 55 mg/dl).
  
  
  CONCLUSIONS
  It leads to the conclusion that mini-fasting test might avoid, in most cases, prolonged fasting test for the diagnosis of hypoglycemia due to endogenous hyperinsulinism.
authors.affiliation: Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil.
authors.forename: J S
authors.initials: JS
authors.lastname: Felício
authors.affiliation: Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil.
authors.forename: C C
authors.initials: CC
authors.lastname: Koury
authors.affiliation: Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil.
authors.forename: C L L P
authors.initials: CL
authors.lastname: Martins
authors.affiliation: Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil.
authors.forename: K B
authors.initials: KB
authors.lastname: Miléo
authors.affiliation: Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil.
authors.forename: J F A
authors.initials: JF
authors.lastname: Neto
authors.affiliation: Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil.
authors.forename: F T C
authors.initials: FT
authors.lastname: de Melo
authors.affiliation: Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil.
authors.forename: A C C B
authors.initials: AC
authors.lastname: de Souza
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood*; D002675:Child, Preschool; D005215:Fasting / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000175:diagnosis*; D007223:Infant; D007328:Insulin / Q000097:blood*; D007340:Insulinoma / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin