title: Small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis.
abstract: OBJECTIVE
  To date, no studies concerning the presence of small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis were published. Based upon characteristic of progressive familial intrahepatic cholestasis one can expect the coexistence of small intestinal bacterial overgrowth. The aim of the study was to assess the incidence of small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis.
  
  
  METHODS
  26 patients aged 8 to 25 years with progressive familial intrahepatic cholestasis were included in the study. Molecular analysis of ABCB11 gene was performed in the vast majority of patients. In all patients Z-score for body weight and height, biochemical tests (bilirubin, bile acid concentration, fecal fat excretion) were assessed. In all patients hydrogen-methane breath test was performed.
  
  
  RESULTS
  On the basis of first hydrogen-methane breath test, diagnosis of small intestinal bacterial overgrowth was confirmed in 9 patients (35%), 5 patients (19%) had borderline results. The second breath test was performed in 10 patients: in 3 patients results were still positive and 2 patients had a borderline result. The third breath test was conducted in 2 patients and positive results were still observed. Statistical analysis did not reveal any significant correlations between clinical, biochemical and therapeutic parameters in patients with progressive familial intrahepatic cholestasis and coexistence of small intestinal bacterial overgrowth.
  
  
  CONCLUSIONS
  Our results suggest that small intestinal bacterial overgrowth is frequent in patients with progressive familial intrahepatic cholestasis. Moreover, it seems that this condition has the tendency to persist or recur, despite the treatment.
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, Poznań, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Lisowska
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, Poznań, Poland.
authors.forename: Natalia
authors.initials: N
authors.lastname: Kobelska-Dubiel
authors.affiliation: Department of Gastroenterology, Hepatology and Nutrition, Children's Memorial Health Institute, Warszawa, Poland.
authors.forename: Irena
authors.initials: I
authors.lastname: Jankowska
authors.affiliation: Department of Gastroenterology, Hepatology and Nutrition, Children's Memorial Health Institute, Warszawa, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Pawłowska
authors.affiliation: Department of Computer Science and Statistics, Poznań University of Medical Sciences, Poznań, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Moczko
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, Poznań, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Walkowiak
mesh_terms: D000074020:ATP Binding Cassette Transporter, Subfamily B, Member 11; D018528:ATP-Binding Cassette Transporters / Q000096:biosynthesis; D000328:Adult; D001419:Bacteria / Q000254:growth & development* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000150:complications / Q000235:genetics / Q000382:microbiology / Q000473:pathology; D001944:Breath Tests; D002648:Child; D002780:Cholestasis, Intrahepatic / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000382:microbiology / Q000473:pathology*; D008297:Male
chemical_list: C093491:ABCB11 protein, human; D000074020:ATP Binding Cassette Transporter, Subfamily B, Member 11; D018528:ATP-Binding Cassette Transporters