title: Synthesis of new 2,5-di-substituted 1,3,4-oxadiazoles bearing 2,6-di-tert-butylphenol moieties and evaluation of their antioxidant activity.
abstract: Eleven new 2,6-di-tert-butyl-4-(5-aryl-1,3,4-oxadiazol-2-yl)phenols 5a-k were synthesized by reacting aryl hydrazides with 3,5-di-tert butyl 4-hydroxybenzoic acid in the presence of phosphorus oxychloride. The resulting compounds were characterized based on their IR, ¹H-NMR, ¹³C-NMR, and HRMS data. 2,2-Diphenyl-1-picrylhydrazide (DPPH) and ferric reducing antioxidant power (FRAP) assays were used to test the antioxidant properties of the compounds. Compounds 5f and 5j exhibited significant free-radical scavenging ability in both assays.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. raiedalsayab@yahoo.co.uk.
authors.forename: Raied M
authors.initials: RM
authors.lastname: Shakir
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. azhar70@um.edu.my.
authors.forename: Azhar
authors.initials: A
authors.lastname: Ariffin
authors.affiliation: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. ammeen@um.edu.my.
authors.forename: Mahmood Ameen
authors.initials: MA
authors.lastname: Abdulla
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors; D020128:Inhibitory Concentration 50; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D010636:Phenols / Q000737:chemistry*; D010851:Picrates / Q000037:antagonists & inhibitors
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D010069:Oxadiazoles; D010636:Phenols; D010851:Picrates; C035407:2,6-di-tert-butylphenol; C004931:1,1-diphenyl-2-picrylhydrazyl