title: The gastric microbial community, Helicobacter pylori colonization, and disease.
abstract: Long thought to be a sterile habitat, the stomach contains a diverse and unique community of bacteria. One particular inhabitant, Helicobacter pylori, colonizes half of the world's human population and establishes a decades-long infection that can be asymptomatic, pathogenic, or even beneficial for the host. Many host and bacterial factors are known to influence an individual's risk of gastric disease, but another potentially important determinant has recently come to light: the host microbiota. Although it is unclear to what extent H. pylori infection perturbs the established gastric microbial community, and H. pylori colonization seems generally resistant to disturbances in the host microbiota, it can modulate H. pylori pathogenicity. Interactions between H. pylori and bacteria at non-gastric sites are likely indirect--via programming of the pro-inflammatory vs. regulatory T lymphocytes--which may have a significant impact on human health.
authors.affiliation: Department of Medicine; University of California-Davis; Davis, CA USA; Department of Microbiology & Immunology; University of California-Davis; Davis, CA USA.
authors.forename: Miriam E
authors.initials: ME
authors.lastname: Martin
authors.affiliation: Department of Medicine; University of California-Davis; Davis, CA USA; Department of Microbiology & Immunology; University of California-Davis; Davis, CA USA; California National Primate Research Center; University of California-Davis; Davis, CA USA.
authors.forename: Jay V
authors.initials: JV
authors.lastname: Solnick
mesh_terms: D000818:Animals; D058448:Biota; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000382:microbiology*; D016481:Helicobacter Infections / Q000382:microbiology* / Q000473:pathology*; D016480:Helicobacter pylori / Q000254:growth & development*; D006801:Humans; D008253:Macaca mulatta; D056265:Microbial Interactions
keywords: 16S rDNA; Helicobacter pylori; disease; human; microbial community; microbiota; mouse; rhesus monkey; stomach