title: Cidea control of lipid storage and secretion in mouse and human sebaceous glands.
abstract: Sebaceous glands are skin appendages that secrete sebum onto hair follicles to lubricate the hair and maintain skin homeostasis. In this study, we demonstrated that Cidea is expressed at high levels in lipid-laden mature sebocytes and that Cidea deficiency led to dry hair and hair loss in aged mice. In addition, Cidea-deficient mice had markedly reduced levels of skin surface lipids, including triacylglycerides (TAGs) and wax diesters (WDEs), and these mice were defective in water repulsion and thermoregulation. Furthermore, we observed that Cidea-deficient sebocytes accumulated a large number of smaller-sized lipid droplets (LDs), whereas overexpression of Cidea in human SZ95 sebocytes resulted in increased lipid storage and the accumulation of large LDs. Importantly, Cidea was highly expressed in human sebaceous glands, and its expression levels were positively correlated with human sebum secretion. Our data revealed that Cidea is a crucial regulator of sebaceous gland lipid storage and sebum lipid secretion in mammals and humans.
authors.affiliation: MOE Key Laboratory of Bioinformatics and Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, People's Republic of China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Zhang
authors.forename: Guanghou
authors.initials: G
authors.lastname: Shui
authors.forename: Guanqun
authors.initials: G
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Shuhong
authors.initials: S
authors.lastname: Sun
authors.forename: Christos C
authors.initials: CC
authors.lastname: Zouboulis
authors.forename: Ran
authors.initials: R
authors.lastname: Xiao
authors.forename: Jing
authors.initials: J
authors.lastname: Ye
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Li
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000502:physiology*; D001833:Body Temperature Regulation; D002460:Cell Line; D004817:Epidermis / Q000378:metabolism; D006197:Hair / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D051379:Mice; D018345:Mice, Knockout; D009928:Organ Specificity; D012627:Sebaceous Glands / Q000166:cytology / Q000378:metabolism*; D012629:Sebum / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; C112510:Cidea protein, mouse; D014280:Triglycerides