title: Intercellular adhesion molecule-1 polymorphisms in patients with Behçet disease: a meta-analysis.
abstract: OBJECTIVE
  To examine the association between the Intercellular adhesion molecule-1 (ICAM1) Polymorphisms and Behçet's disease.
  
  
  METHODS
  MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials for original studies up to July 31, 2012 were searched for relevant studies. All pooled odds ratios (ORs) were derived from either fixed or random-effects model with its 95% confidence intervals (CI).
  
  
  RESULTS
  Five studies met the inclusion criteria. Overall, ICAM1 E469 (OR = 1.45, 95% CI = 1.06-1.97), genotype ICAM1 469 E/E (OR = 1.45, 95% CI = 1.09-1.94), ICAM1 241 G/R (OR = 3.65, 95% CI = 1.69-7.89), had significant associations with Behçet's disease. A significant association was found between the presence of skin lesions and genotype ICAM1 469 E/E (OR = 3.52, 95% CI = 1.62-7.66).
  
  
  CONCLUSIONS
  Behçet's disease was associated with the ICAM1 E469, genotype ICAM1 469 E/E, ICAM1 241 G/R polymorphisms in different ethnic groups. Among patients, genotype ICAM1 469 E/E had a significant association with skin lesion.
authors.affiliation: Department of Rheumatology, Huadong Hospital, Fudan University , Shanghai , P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zou
authors.forename: Jian-Long
authors.initials: JL
authors.lastname: Guan
mesh_terms: D000483:Alleles; D001528:Behcet Syndrome / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D018799:Intercellular Adhesion Molecule-1