title: The different faces of Creutzfeldt-Jacob disease CJD in psychiatry.
abstract: OBJECTIVE
  Creutzfeldt-Jacob Disease (CJD) is a rapidly progressive spongiform disease of the central nervous system. Psychiatric symptoms, though considered rare, can be the presenting symptoms of CJD and impose diagnosis difficulties. We reviewed prospectively our database to identify the frequency of psychiatric symptoms as identifying symptoms among our community.
  
  
  METHODS
  We included all patients in Sheba Medical Center who were diagnosed with CJD between the years 2006 and 2012. Data were collected retrospectively.
  
  
  RESULTS
  Twenty-three patients with CJD were admitted to our hospital during this 6-year period. Among them, 10 (44%) were diagnosed first as "psychiatric patients" due to psychiatric presenting symptoms.
  
  
  CONCLUSIONS
  In our series, the frequency of misleading psychiatric symptom was 44%. Clinicians should therefore include CJD in their differential diagnoses of new onset dementia, particularly when associated psychosis and depression symptoms persist and worsen, despite standard psychiatric treatments.
authors.affiliation: Department of Psychiatry A, Chaim Sheba Medical Center, Tel Hashomer, Israel. Electronic address: anatabudy@gmail.com.
authors.forename: Anat
authors.initials: A
authors.lastname: Abudy
authors.affiliation: Department of Psychiatry A, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Alzbeta
authors.initials: A
authors.lastname: Juven-Wetzler
authors.affiliation: Department of Psychiatry A, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Joseph
authors.initials: J
authors.lastname: Zohar
mesh_terms: D000328:Adult; D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged
keywords: Creutzfeldt-Jakob disease (CJD); Dementia; Neurodegenerative disorder; Psychiatric aspects; Psychiatry