title: Lipogenic gene expression profile in patients with gastric cancer.
abstract: Numerous types of cancer exhibit increased lipogenesis and expression of lipogenic enzymes and transcription factors, including sterol regulatory element-binding protein-1. Lipogenic gene expression is upregulated at the mRNA level, in concert with metabolic pathways associated with changes in expression and/or activity of lipogenic transcription factors. However, this expression pattern in human gastric carcinoma has not been elucidated. In this study, lipogenic gene expression in cancer tissues was investigated using quantitative PCR. In patients with gastric cancer,carnitine O-palmitoyltransferase type ImRNA andmiR-33bwere significantly downregulated, suggesting thatmiR-33bdownregulation is mediated by conditions that also affect the expression and/or activity of transcription factors involved in lipogenic gene expression. Consequently, the association betweenmiR-33band gastric cancer may provide a novel strategy for the genetic diagnosis of gastric cancer. However, additional studies including a larger number of samples are required to confirm these results.
authors.affiliation: Department of Surgery, Nikko Medical Center, Dokkyo Medical University, Shimotsuga-gun, Tochigi, 321-0293, Japan.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Miyachi
authors.affiliation: Department of Materials and Life Science, Seikei University, Musashino, Tokyo 180-8633, Japan.
authors.forename: Youki
authors.initials: Y
authors.lastname: Sawada
authors.affiliation: Department of Surgery, Nikko Medical Center, Dokkyo Medical University, Shimotsuga-gun, Tochigi, 321-0293, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Shida
authors.affiliation: Department of Surgery, Nikko Medical Center, Dokkyo Medical University, Shimotsuga-gun, Tochigi, 321-0293, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Sugawara
authors.affiliation: Department of Materials and Life Science, Seikei University, Musashino, Tokyo 180-8633, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Hisatomi
keywords: carnitine O-palmitoyltransferase type I; gastric cancer; miR-33b; sterol regulatory element-binding protein-1