title: [Prolonged-release drug formulations for parenteral administration. Part II. Microspheres and implants for injection].
abstract: Microspheres and implants are injectable drug forms, which by special design and selection of appropriate excipients, provide for a long time constant release rate of an active substance in the body. Development of both would not be possible without advances in polymer technology and invention of safe and biocompatible polymers such as: polyesters, vinyl acetate derivatives or silicones. Polymeric matrices provide retardation of drug release--for some implants up to a few years. In addition, this paper presents examples of all commercially available medicinal products containing microspheres and implants, currently registered in Poland, together with their characteristics: composition, time course and frequency of administration. Comments are also enclosed on frequently occurring inconsistent terminology in pharmaceutical forms.
authors.forename: Margin
authors.initials: M
authors.lastname: Płaczek
authors.forename: Julia
authors.initials: J
authors.lastname: Jacyna
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sznitowska
mesh_terms: D001672:Biocompatible Materials; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004343:Drug Implants; D007263:Infusions, Parenteral; D007267:Injections; D008863:Microspheres; D011108:Polymers; D012828:Silicones; D014753:Vinyl Compounds
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004343:Drug Implants; D011108:Polymers; D012828:Silicones; D014753:Vinyl Compounds; C011566:vinyl acetate