title: RNA identity crisis: hepatitis B walks the LINE.
abstract: Hepatitis B virus (HBV) integration into the host genome has been implicated in the causation of hepatocellular carcinoma (HCC). In this issue of Cancer Cell, Lau and colleagues report an HBV integration site recurrent in HCC that generates a chimeric transcript with oncogenic function as an RNA (but not protein) through stimulation of Wnt/β-catenin signaling.
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Yashar S
authors.initials: YS
authors.lastname: Niknafs
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: arul@med.umich.edu.
authors.forename: Arul M
authors.initials: AM
authors.lastname: Chinnaiyan
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*; D014760:Viral Fusion Proteins / Q000235:genetics*; D054334:Viral Regulatory and Accessory Proteins
chemical_list: D004268:DNA-Binding Proteins; D015534:Trans-Activators; D014760:Viral Fusion Proteins; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein; C077214:L1Hs-encoded protein p40, human