title: Adverse lipid profile is not associated with relapse risk in MS: results from an observational cohort study.
abstract: BACKGROUND
  There is increasing evidence that serum lipids and apolipoproteins may be associated with multiple sclerosis (MS) clinical course.
  
  
  OBJECTIVE
  To investigate the associations between serum lipids, apolipoproteins, body mass index and relapse in MS.
  
  
  METHODS
  A prospective cohort of 141 participants with relapsing-remitting MS was followed from 2002 to 2005. Serum lipid and apolipoprotein levels were measured biannually, and body mass index at baseline. The association with hazard of relapse was assessed using survival analysis.
  
  
  RESULTS
  Neither body mass index nor any of the lipid-related measures were associated with the hazard of relapse.
  
  
  CONCLUSIONS
  Serum lipid profile and body mass index are not associated with the hazard of relapse in MS.
authors.affiliation: Menzies Research Institute Tasmania, University of Tasmania, Australia. Electronic address: prudence.tettey@utas.edu.au.
authors.forename: Prudence
authors.initials: P
authors.lastname: Tettey
authors.affiliation: Menzies Research Institute Tasmania, University of Tasmania, Australia.
authors.forename: Steve
authors.initials: S
authors.lastname: Simpson
authors.affiliation: Menzies Research Institute Tasmania, University of Tasmania, Australia.
authors.forename: Bruce
authors.initials: B
authors.lastname: Taylor
authors.affiliation: Menzies Research Institute Tasmania, University of Tasmania, Australia.
authors.forename: Leigh
authors.initials: L
authors.lastname: Blizzard
authors.affiliation: Murdoch Children's Research Institute, University of Melbourne, Australia.
authors.forename: Anne-Louise
authors.initials: AL
authors.lastname: Ponsonby
authors.affiliation: Murdoch Children's Research Institute, University of Melbourne, Australia.
authors.forename: Terence
authors.initials: T
authors.lastname: Dwyer
authors.affiliation: Mater Hospital, University of Queensland, Australia.
authors.forename: Karam
authors.initials: K
authors.lastname: Kostner
authors.affiliation: Menzies Research Institute Tasmania, University of Tasmania, Australia.
authors.forename: Ingrid
authors.initials: I
authors.lastname: van der Mei
mesh_terms: D001053:Apolipoproteins / Q000097:blood*; D015992:Body Mass Index; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000175:diagnosis*; D019370:Observation; D016016:Proportional Hazards Models; D012008:Recurrence; D012306:Risk
chemical_list: D001053:Apolipoproteins; D008055:Lipids
keywords: Apolipoprotein; Cholesterol; Lipid; Multiple sclerosis; Profile; Relapse