title: Maximum standardized uptake value in18F-fluoro-2-deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer.
abstract: Positron emission tomography/computed tomography (PET/CT) with18F-fluoro-2-deoxyglucose (FDG-PET/CT) has become established in cancer imaging, and derived maximum standardized uptake values (SUVmax) add functional information regarding cancer, including esophageal squamous cell carcinoma (ESCC). The aim of the present study was to determine the clinical significance and association of tumor progression using SUVmax derived from PET/CT images in patients with ESCC. In total, 101 patients with ESCC were assessed using FDG-PET/CT and the SUVmax was then compared with the clinical backgrounds and prognoses of the patients. Endoscopic ESCC biopsy specimens were obtained in order to analyze mRNA expression relative to tumor progression. The results showed that values for SUVmax were significantly higher in patients with tumor progression factors, particularly those with lymph node metastasis. Analysis of receiver operating characteristics curves revealed an optimum SUVmax cut-off value of 10.26 for node-positive disease. Patients with SUVmax ≥10.26 had gene alterations with epithelial-mesenchymal transition (EMT) and significantly worse overall survival (P=0.0012). A higher SUVmax in patients with ESCC was associated with lymph node metastasis and a poorer prognosis. Thus, the SUVmax may reflect the potential of EMT in patients with ESCC.
authors.affiliation: Department of Gastroenterology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791-0280, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kajiwara
authors.affiliation: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiasa
authors.affiliation: Department of Gastroenterology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791-0280, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nishina
authors.affiliation: Department of Gastroenterology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791-0280, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Matsumoto
authors.affiliation: Department of Gastroenterology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791-0280, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Hori
authors.affiliation: Department of Gastroenterology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791-0280, Japan.
authors.forename: Seijin
authors.initials: S
authors.lastname: Nadano
authors.affiliation: Department of Gastroenterology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791-0280, Japan.
authors.forename: Haruo
authors.initials: H
authors.lastname: Iguchi
authors.affiliation: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Takeji
authors.affiliation: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Tsubouchi
authors.affiliation: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ikeda
authors.affiliation: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan.
authors.forename: Morikazu
authors.initials: M
authors.lastname: Onji
keywords: 18F-fluoro-2-deoxyglucose; epithelial-mesenchymal transition; esophageal squamous cell carcinoma; maximum standardized uptake value; positron emission tomography