title: Dynamics of histone variant H3.3 and its coregulation with H2A.Z at enhancers and promoters.
abstract: In eukaryotes, genomic DNA is hierarchically packaged into chromatin by histones. A defined organization of the genome into chromatin with specific patterns of epigenetic modifications is crucial for transcriptional regulation, cell fate determination, and maintenance, in which the histone variant incorporation has been characterized as one of the most key players. The diversity of histone variants results in structural plasticity of chromatin and highlights functionally distinct chromosomal domains. Here we focus on the role of histone variant H3.3 and its coregulation with H2A.Z in chromatin dynamics at enhancers and promoters and transcriptional regulation.
authors.affiliation: National Laboratory of Biomacromolecules; Institute of Biophysics; Chinese Academy of Sciences; Beijing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.affiliation: National Laboratory of Biomacromolecules; Institute of Biophysics; Chinese Academy of Sciences; Beijing, China; University of Chinese Academy of Sciences; Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: National Laboratory of Biomacromolecules; Institute of Biophysics; Chinese Academy of Sciences; Beijing, China.
authors.forename: Guohong
authors.initials: G
authors.lastname: Li
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics; D004247:DNA / Q000235:genetics; D019175:DNA Methylation; D004742:Enhancer Elements, Genetic; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D016678:Genome; D006657:Histones / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D002843:Chromatin; D006657:Histones; D014157:Transcription Factors; D004247:DNA
keywords: H2A.Z; H3.3; chromatin dynamics; histone variant; transcriptional regulation