title: Progressive multiple cystic changes in both lungs in a patient treated with gefitinib for lung adenocarcinoma with multiple lung metastases.
abstract: Gefitinib is regarded as a relatively safe agent for the treatment of an advanced non-small cell lung cancer (NSCLC). Pulmonary toxicity such as interstitial lung disease associated with gefitinib is uncommon with an estimated all time incidence around 1% worldwide. Moreover, a case of gefitinib associated with pulmonary cystic changes has not been reported yet. In this report we present a case of progressive multiple air cystic changes in both lungs in a patient with NSCLC and intrapulmonary metastases who underwent a gefitinib therapy.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul 158-710, Korea.
authors.forename: Yon Ju
authors.initials: YJ
authors.lastname: Ryu
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul 158-710, Korea.
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Chun
authors.affiliation: Division of Hemato-Oncology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul 158-710, Korea.
authors.forename: Soon Nam
authors.initials: SN
authors.lastname: Lee
authors.affiliation: Department of Radiology, Ewha Womans University School of Medicine, Seoul 158-710, Korea.
authors.forename: Sung Shin
authors.initials: SS
authors.lastname: Shim
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000556:secondary; D003560:Cysts / Q000139:chemically induced*; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced*; D017563:Lung Diseases, Interstitial; D008175:Lung Neoplasms / Q000188:drug therapy*; D008875:Middle Aged; D011799:Quinazolines / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D000077156:Gefitinib
keywords: Cystic change; Gefitinib; Non-small cell lung cancer