title: Expression of Tiam1 predicts lymph node metastasis and poor survival of lung adenocarcinoma patients.
abstract: BACKGROUND
  To assess the value of Tiam1 in predicting lymph node metastasis and survival after curative resection in patients with lung adenocarcinoma.
  
  
  METHODS
  Immunohistochemical staining for Tiam1 was performed on 98 adenocarcinoma and 30 normal lung tissues. The association of Tiam1 protein expression with the clinicopathological characteristics and the prognosis of lung adenocarcinoma were subsequently assessed.
  
  
  RESULTS
  Immunohistochemical analysis showed that 60 of 98 (61.22%) adenocarcinoma tissues showed high expression of Tiam1, and high Tiam1 expression was significantly associated with advanced TNM stage (P < 0.0005) and lymph node status (P < 0.0005) of lung adenocarcinoma. Moreover, the lung adenocarcinoma patients with low Tiam1 expression had higher overall survival than patients with high Tiam1 expression (log rank value = 10.805, P = 0.001). High expression of Tiam1 predicted poor overall survival of patients in stages I + II (P = 0.006). Furthermore, multivariate analysis indicated that high expression of Tiam1 protein was an independent prognostic factor for overall survival (P = 0.011) in patients with lung adenocarcinoma.
  
  
  CONCLUSIONS
  These findings suggest for the first time that Tiam1 expression may be beneficial in predicting lymph node metastasis and survival of patients with lung adenocarcinoma. A future study will investigate whether Tiam1 can serve as a novel therapeutic target in lung adenocarcinoma.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1377798917111123.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Liu
authors.forename: Yumei
authors.initials: Y
authors.lastname: Li
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Qi
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Zhao
authors.forename: Aili
authors.initials: A
authors.lastname: Huang
authors.forename: Wenjie
authors.initials: W
authors.lastname: Sheng
authors.forename: Bin
authors.initials: B
authors.lastname: Lei
authors.forename: Peixin
authors.initials: P
authors.lastname: Lin
authors.forename: Haili
authors.initials: H
authors.lastname: Zhu
authors.forename: Wenxia
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University, 510515 Tonghe, Guangzhou, People's Republic of China. shenhong2010168@163.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D020662:Guanine Nucleotide Exchange Factors / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D000075684:T-Lymphoma Invasion and Metastasis-inducing Protein 1
chemical_list: D014408:Biomarkers, Tumor; D020662:Guanine Nucleotide Exchange Factors; D000075684:T-Lymphoma Invasion and Metastasis-inducing Protein 1; C087334:TIAM1 protein, human