title: [Effects of exposure to high-energy protons on rat's behavior and underlying neurochemical mechanisms].
abstract: Effects of 1.5 and 3 Gy from high-energy protons (165 MeV) on rat's motor and oriented trying activities, rate of the Y-labyrinth learning with electric pain stimulation, and levels of monoamines and their metabolites in different brain structures were studied. The experimental results showed that irradiation with these proton doses caused considerable inhibition of the motor and oriented trying activities, and strengthening of passive defense reactions in the open field test; however, no significant change was induced in the learning rate or monoamines turnover. Apparently, emotional and motivational systems were affected to a greater degree than cognitive functions.
authors.forename: A S
authors.initials: AS
authors.lastname: Shtemberg
authors.forename: A S
authors.initials: AS
authors.lastname: Bazian
authors.forename: K B
authors.initials: KB
authors.lastname: Lebedeva-Georgievskaya
authors.forename: M I
authors.initials: MI
authors.lastname: Matveeva
authors.forename: V S
authors.initials: VS
authors.lastname: Kudrin
authors.forename: V B
authors.initials: VB
authors.lastname: Narkevich
authors.forename: P M
authors.initials: PM
authors.lastname: Klodt
authors.forename: V S
authors.initials: VS
authors.lastname: Kokhan
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000528:radiation effects*; D001921:Brain / Q000528:radiation effects*; D003071:Cognition / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D018782:Maze Learning / Q000528:radiation effects*; D009043:Motor Activity / Q000528:radiation effects; D011522:Protons; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011522:Protons