title: In the end, what's the problem?
abstract: In this issue, Soudet et al. show that the actual mechanistic details of the chromosomal end-replication problem, the principle linking telomere biology with human cellular senescence and cancer, match previous predictions almost to the nucleotide.
authors.affiliation: Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada. Electronic address: Raymund.Wellinger@Usherbrooke.ca.
authors.forename: Raymund J
authors.initials: RJ
authors.lastname: Wellinger
mesh_terms: D015825:Chromosomes, Fungal; D004261:DNA Replication; D004277:DNA, Single-Stranded; D015966:Gene Expression Regulation, Fungal; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D016615:Telomere / Q000737:chemistry*
chemical_list: D004277:DNA, Single-Stranded