title: Spatiotemporal organization and mechanosensory function of podosomes.
abstract: Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are associated with an actin network and often organize into large clusters. Recent results from our laboratory and others have shed new light on podosome structure and dynamics, suggesting a revision of the classical "core-ring" model. Also, these studies demonstrate that the adhesive and protrusive module are functionally linked by the actin network likely facilitating mechanotransduction as well as providing feedback between these two modules. In this commentary, we briefly summarize these recent advances with respect to the knowledge on podosome structure and discuss force distribution mechanisms within podosomes and their emerging role in mechanotransduction.
authors.affiliation: Department of Tumor Immunology; Radboud Institute for Molecular Life Sciences; Radboud University Medical Center; Nijmegen, The Netherlands.
authors.forename: Koen
authors.initials: K
authors.lastname: van den Dries
authors.affiliation: Department of Tumor Immunology; Radboud Institute for Molecular Life Sciences; Radboud University Medical Center; Nijmegen, The Netherlands.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bolomini-Vittori
authors.affiliation: Department of Tumor Immunology; Radboud Institute for Molecular Life Sciences; Radboud University Medical Center; Nijmegen, The Netherlands; Department of Nanobiophysics; MESA+ Institute for Nanotechnology and MIRA Institute for Biomedical Technology and Technical Medicine; University of Twente; Enschede, The Netherlands.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cambi
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*
chemical_list: D000199:Actins
keywords: actin; cell adhesion; invadopodia; mechanotransduction; podosome; tension