title: Efficacy of afoxolaner against Dermacentor variabilis ticks in dogs.
abstract: Efficacy of afoxolaner, a novel isoxazoline insecticide/acaricide, against Dermacentor variabilis ticks was confirmed in two laboratory studies. Each study utilized a controlled, randomized block design. One day prior to treatment, beagle dogs were infested with 50 unfed adult ticks. Repeat infestations were performed weekly for four weeks. The number of live ticks remaining on each dog was determined 48 h after treatment and after each subsequent infestation. A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations by D. variabilis ticks and controlled weekly re-infestations with 99.7-100% efficacy up to Day 23 and >97% efficacy at Day 30.
authors.affiliation: Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096, USA. Electronic address: Elizabeth.Mitchell@Merial.com.
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Mitchell
authors.affiliation: Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Dorr
authors.affiliation: BerTek, Inc., 104 Wilson Bottoms Road, Greenbrier, AR 72058, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Everett
authors.affiliation: Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096, USA.
authors.forename: Theodore S
authors.initials: TS
authors.lastname: Chester
authors.affiliation: Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Larsen
mesh_terms: D056810:Acaricides / Q000008:administration & dosage*; D000818:Animals; D003870:Dermacentor / Q000502:physiology*; D004283:Dog Diseases / Q000188:drug therapy* / Q000517:prevention & control; D004285:Dogs; D005260:Female; D008297:Male; D011897:Random Allocation; D013984:Tick Infestations / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D056810:Acaricides
keywords: Afoxolaner; Dermacentor variabilis; Dogs; Ticks