title: The association between TGF-β1 polymorphisms and radiation pneumonia in lung cancer patients treated with definitive radiotherapy: a meta-analysis.
abstract: BACKGROUND
  Previous studies investigating the association between TGF-β1 polymorphisms and Radiation Pneumonia (RP) risk have provided inconsistent results. The aim of our study was to assess the association between the TGF-β1 genes C509T, G915C and T869C polymorphisms and risk of RP in lung cancer patients treated with definitive radiotherapy.
  
  
  METHODS
  Two investigators independently searched the Medline, Embase, CNKI, and Chinese Biomedicine Databases for studies published before September 2013. Summary odds ratios (ORs) and 95% confidence intervals (CIs) for TGF-β1 polymorphisms and RP were calculated in a fixed-effects model or a random-effects model when appropriate.
  
  
  RESULTS
  Ultimately, each 7 studies were found to be eligible for meta-analyses of C509T, G915C and T869C, respectively. Our analysis suggested that the variant genotypes of T869C were associated with a significantly increased RP risk in dominant model (OR = 0.59, 95% CI = 0.45-0.79) and CT vs. TT model (OR = 0.47, 95% CI = 0.32-0.69). In the subgroup analyses by ethnicity/country, a significantly increased risk was observed among Caucasians. For C509T and G915C polymorphism, no obvious associations were found for all genetic models.
  
  
  CONCLUSIONS
  This meta-analysis suggests that T869C polymorphism of TGF-β1 may be associated with RP risk only in Caucasians, and there may be no association between C509T and G915C polymorphism and RP risk.
authors.affiliation: Department of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Jiazhuo
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Deng
authors.affiliation: Department of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Na
authors.affiliation: Department of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Xue
authors.affiliation: Department of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: You
authors.initials: Y
authors.lastname: Lu
mesh_terms: D044466:Asian People; D005720:Gamma Rays / Q000009:adverse effects* / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy*; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017564:Radiation Pneumonitis / Q000208:ethnology / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D012306:Risk; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D044465:White People
chemical_list: D053773:Transforming Growth Factor beta1