title: Tissue plasminogen activator and inflammation: from phenotype to signaling mechanisms.
abstract: In disease conditions, inflammatory cells, such as neutrophils, T cells, and monocytes/macrophages, are recruited in response to injury cues and express panoply of proinflammatory genes through a combination of transcription factors. Tissue plasminogen activator (tPA), a member of the serine protease family, has been shown to act as cytokine to activate profound receptor-mediated signaling events. In this review, we will discuss the role of tPA in inflammation in various models, and illuminate its signaling mechanisms underlying its modulation of inflammation.
authors.affiliation: Division of Nephrology, Department of Medicine, Penn State University College of Medicine Hershey, Pennsylvania, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Lin
authors.affiliation: Division of Nephrology, Department of Medicine, Penn State University College of Medicine Hershey, Pennsylvania, USA.
authors.forename: Kebin
authors.initials: K
authors.lastname: Hu
keywords: Tissue plasminogen activator; inflammation; phenotype; signaling mechanisms; tPA