title: Regioselective chemoenzymatic synthesis of ganglioside disialyl tetrasaccharide epitopes.
abstract: A novel chemoenzymatic approach for the synthesis of disialyl tetrasaccharide epitopes found as the terminal oligosaccharides of GD1α, GT1aα, and GQ1bα is described. It relies on chemical manipulation of enzymatically generated trisaccharides as conformationally constrained acceptors for regioselective enzymatic α2-6-sialylation. This strategy provides a new route for easy access to disialyl tetrasaccharide epitopes and their derivatives.
authors.affiliation: National Glycoengineering Research Center, School of Pharmaceutical Science, Shandong University , Jinan 250012, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Meng
authors.forename: Wenlong
authors.initials: W
authors.lastname: Yao
authors.forename: Jiansong
authors.initials: J
authors.lastname: Cheng
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Lan
authors.initials: L
authors.lastname: Jin
authors.forename: Hai
authors.initials: H
authors.lastname: Yu
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Fengshan
authors.initials: F
authors.lastname: Wang
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Cao
mesh_terms: D002236:Carbohydrate Conformation; D000939:Epitopes / Q000096:biosynthesis* / Q000737:chemistry; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000096:biosynthesis* / Q000737:chemistry; D012799:Sialyltransferases / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D000939:Epitopes; D009844:Oligosaccharides; D012799:Sialyltransferases