title: Revealing the cerebral regions and networks mediating vulnerability to depression: oxidative metabolism mapping of rat brain.
abstract: The large variety of available animal models has revealed much on the neurobiology of depression, but each model appears as specific to a significant extent, and distinction between stress response, pathogenesis of depression and underlying vulnerability is difficult to make. Evidence from epidemiological studies suggests that depression occurs in biologically predisposed subjects under impact of adverse life events. We applied the diathesis-stress concept to reveal brain regions and functional networks that mediate vulnerability to depression and response to chronic stress by collapsing data on cerebral long term neuronal activity as measured by cytochrome c oxidase histochemistry in distinct animal models. Rats were rendered vulnerable to depression either by partial serotonergic lesion or by maternal deprivation, or selected for a vulnerable phenotype (low positive affect, low novelty-related activity or high hedonic response). Environmental adversity was brought about by applying chronic variable stress or chronic social defeat. Several brain regions, most significantly median raphe, habenula, retrosplenial cortex and reticular thalamus, were universally implicated in long-term metabolic stress response, vulnerability to depression, or both. Vulnerability was associated with higher oxidative metabolism levels as compared to resilience to chronic stress. Chronic stress, in contrast, had three distinct patterns of effect on oxidative metabolism in vulnerable vs. resilient animals. In general, associations between regional activities in several brain circuits were strongest in vulnerable animals, and chronic stress disrupted this interrelatedness. These findings highlight networks that underlie resilience to stress, and the distinct response to stress that occurs in vulnerable subjects.
authors.affiliation: Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Ravila 14A, 50411 Tartu, Estonia. Electronic address: jaanus.harro@ut.ee.
authors.forename: Jaanus
authors.initials: J
authors.lastname: Harro
authors.affiliation: Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Ravila 14A, 50411 Tartu, Estonia.
authors.forename: Margus
authors.initials: M
authors.lastname: Kanarik
authors.affiliation: Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Kreutzwaldi 1, 51014 Tartu, Estonia.
authors.forename: Tanel
authors.initials: T
authors.lastname: Kaart
authors.affiliation: Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Ravila 14A, 50411 Tartu, Estonia.
authors.forename: Denis
authors.initials: D
authors.lastname: Matrov
authors.affiliation: Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Ravila 14A, 50411 Tartu, Estonia.
authors.forename: Kadri
authors.initials: K
authors.lastname: Kõiv
authors.affiliation: Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Ravila 14A, 50411 Tartu, Estonia.
authors.forename: Tanel
authors.initials: T
authors.lastname: Mällo
authors.affiliation: Department of Pharmacology, School of Medicine, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
authors.forename: Joaquin
authors.initials: J
authors.lastname: Del Río
authors.affiliation: Department of Pharmacology, School of Medicine, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Tordera
authors.affiliation: Department of Pharmacology, School of Medicine, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Ramirez
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D002908:Chronic Disease; D003866:Depressive Disorder / Q000209:etiology / Q000503:physiopathology*; D004195:Disease Models, Animal; D004291:Dominance-Subordination; D003576:Electron Transport Complex IV / Q000378:metabolism*; D008297:Male; D008426:Maternal Deprivation; D009434:Neural Pathways / Q000503:physiopathology; D010641:Phenotype; D051381:Rats; D055500:Resilience, Psychological; D018490:Serotonin Agents; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology
chemical_list: D018490:Serotonin Agents; D003576:Electron Transport Complex IV
keywords: Animal model; Chronic stress; Depression; Oxidative metabolism; Resilience; Vulnerability