title: Expression profiles for 14-3-3 zeta and CCL20 in pancreatic cancer and chronic pancreatitis.
abstract: BACKGROUND
  Pancreatic cancer (PCA) has a dismal prognosis because it is often diagnosed at an advanced stage. The overall survival rate is <5% after five years. Chronic pancreatitis (CP) is one of the most important risk factors for PCA. A major difficulty is to distinguish between CP and PCA at both clinical and morphologic level. The aim of this study was to assess the impact of the expression profiles for 14-3-3 zeta and CCL20 to histologically discriminate between PCA and CP.
  
  
  METHODS
  In PCA (n=138) and CP (n=36) tissue samples, the expression of 14-3-3 zeta and CCL20 was examined by immunohistochemistry. Associations between expression profiles of 14-3-3 zeta and CCL20 expression in PCA, CP as well as MANT (matched adjacent normal tissue) (n=138) and clinicopathologic variables were analyzed.
  
  
  RESULTS
  The expression of CCL20 and 14-3-3 zeta was significantly higher in PCA than in CP and MANT. For CP compared to MANT, no significant differences were observed for expression profiles of both 14-3-3 zeta and CCL20.
  
  
  CONCLUSIONS
  CCL20 and 14-3-3 zeta are molecules that play a putative role during tumorgenesis in pancreas, and may therefore be new parameters for histological diagnosis and discrimination between PCA and CP.
authors.affiliation: Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Germany. Electronic address: christoph.klemm@uk-koeln.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Klemm
authors.affiliation: Department of Periodontology, Operative and Preventive Dentistry, University Hospital Bonn, Bonn, Germany; Department of Oral Health Sciences, University of Washington, Seattle, WA, USA.
authors.forename: Henrik
authors.initials: H
authors.lastname: Dommisch
authors.affiliation: Department of Prostate Cancer Research, University Hospital of Bonn, Germany; Institute of Pathology, University Hospital of Bonn, Germany.
authors.forename: Friederike
authors.initials: F
authors.lastname: Göke
authors.affiliation: Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Germany; Department of Radiation Oncology, University of Cologne, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Kreppel
authors.affiliation: Department of Periodontology, Operative and Preventive Dentistry, University Hospital Bonn, Bonn, Germany.
authors.forename: Søren
authors.initials: S
authors.lastname: Jepsen
authors.affiliation: Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany.
authors.forename: Fimmers
authors.initials: F
authors.lastname: Rolf
authors.affiliation: Oncology Center, Helios Clinic Schwerin, Schwerin, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Dommisch
authors.affiliation: Department of Prostate Cancer Research, University Hospital of Bonn, Germany; Institute of Pathology, University Hospital of Bonn, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Perner
authors.affiliation: Center of Integrated Oncology (CIO) Cologne-Bonn, Germany; Department of Surgery, University of Bonn, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Standop
mesh_terms: D048948:14-3-3 Proteins / Q000032:analysis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D054418:Chemokine CCL20 / Q000032:analysis*; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000737:chemistry* / Q000473:pathology; D050500:Pancreatitis, Chronic / Q000378:metabolism* / Q000473:pathology; D011237:Predictive Value of Tests; D015854:Up-Regulation
chemical_list: D048948:14-3-3 Proteins; D014408:Biomarkers, Tumor; C108355:CCL20 protein, human; D054418:Chemokine CCL20; C572235:YWHAZ protein, human
keywords: 14-3-3 zeta; Biomarker; CCL20; Chronic pancreatitis; Diagnosis; Pancreatic cancer; Prognosis