title: Neuroprotective effect of curcumin on hippocampal injury in 6-OHDA-induced Parkinson's disease rat.
abstract: Clinically, Parkinson's disease (PD)-related neuronal lesions commonly occur. The purpose of this study is to investigate potential therapeutic effect of curcumin against hippocampal damage of 6-hydroxydopamine (6-OHDA)-PD rat model. These results showed that curcumin significantly increased the body weight of 6-OHDA-impaired rats (P<0.01), and reversed the anhedonia in rats induced by 6-OHDA impairment (P<0.01). Meanwhile, behavioral manifestations of curcumin-treated PD rats were effectively ameliorated as shown in open field test (P<0.01). In addition, curcumin increased the contents of monoaminergic neurotransmitters (P<0.01), such as dopamine (DA) and norepinephrine (NE), in hippocampal homogenate through high performance liquid chromatography (HPLC) assay. Curcumin effectively alleviated the 6-OHDA-induced hippocampal damage as observed in hematoxylin-eosin (H&E) staining. Furthermore, curcumin obviously up-regulated hippocampal brain derived neurotrophic factor (BDNF), TrkB, phosphatidylinositide 3-kinases (PI3K) protein expressions, respectively as shown in Western blot analysis. These findings demonstrated that curcumin mediated the neuroprotection against 6-OHDA-induced hippocampus neurons in rats, which the underlying mechanism is involved in activating BDNF/TrkB-dependent pathway for promoting neural regeneration of hippocampal tissue.
authors.affiliation: Emergency Neurology, Weifang People's Hospital, Shandong 261041, PR China.
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Emergency Neurology, Weifang People's Hospital, Shandong 261041, PR China.
authors.forename: Shilei
authors.initials: S
authors.lastname: Song
authors.affiliation: Emergency Neurology, Weifang People's Hospital, Shandong 261041, PR China. Electronic address: lijian_hospital@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Guangxi Medical University, Nanning 530021, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liang
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D003474:Curcumin / Q000494:pharmacology*; D019610:Cytoprotection; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009416:Nerve Regeneration / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000523:psychology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D020813:Receptor, trkB / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000978:Antiparkinson Agents; D019208:Brain-Derived Neurotrophic Factor; D018696:Neuroprotective Agents; D016627:Oxidopamine; D019869:Phosphatidylinositol 3-Kinases; D020813:Receptor, trkB; D003474:Curcumin; D004298:Dopamine; D009638:Norepinephrine
keywords: Curcumin; Hippocampi; Neural injury; Neuroprotection