title: Antifungal lock therapy with combined 70% ethanol and micafungin in a critically ill infant.
abstract: So-called lock therapy, consisting of high concentrations of antimicrobials instilled into the lumen of the catheter, has been suggested avoid central venous catheter removal during fungal infection. We report a baby who developed catheter-related candidemia. Systemic antifungal treatment did not resolve the candidemia. Lock therapy with 0.3 mL of ethanol 70% and micafungin sodium 5 mg/L was added to the therapy, and blood cultures became sterile.
authors.affiliation: From the *Department of Neonatology; †Department of Biochemical and Clinical Laboratory; and ‡Pharmacy Unit, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Fiammetta
authors.initials: F
authors.lastname: Piersigilli
authors.forename: Cinzia
authors.initials: C
authors.lastname: Auriti
authors.forename: Iliana
authors.initials: I
authors.lastname: Bersani
authors.forename: Bianca
authors.initials: B
authors.lastname: Goffredo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bianco
authors.forename: Imma
authors.initials: I
authors.lastname: Savarese
authors.forename: Andrea
authors.initials: A
authors.lastname: Dotta
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000302:isolation & purification; D058387:Candidemia / Q000188:drug therapy*; D055499:Catheter-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D062905:Central Venous Catheters / Q000009:adverse effects / Q000382:microbiology*; D016638:Critical Illness; D054714:Echinocandins / Q000627:therapeutic use*; D000431:Ethanol / Q000627:therapeutic use*; D005183:Failure to Thrive; D006801:Humans; D007223:Infant; D055666:Lipopeptides / Q000627:therapeutic use*; D008297:Male; D000077551:Micafungin; D010288:Parenteral Nutrition
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000431:Ethanol; D000077551:Micafungin