title: Radiotherapy- or radical surgery-induced female sexual morbidity in stages IB and II cervical cancer.
abstract: OBJECTIVE
  The objective of this study was to evaluate the sexual function in cervical cancer survivors after radiotherapy (RT) or radical surgery (RS).
  
  
  METHODS
  This was an observational and cross-sectional study. The Female Sexual Function Index (FSFI) self-reported questionnaires were distributed to 175 patients after RT (RT group) or RS (RS group) and 521 healthy women (control) between 2011 and 2012. Sexual functions were compared among these 3 groups.
  
  
  RESULTS
  Eligible 92 patients (46 in RT group, 46 in RS group) and 148 control subjects were included for analysis. There was a significant difference in median (range) FSFI total score of 5.5 (3.6-34.7) in the RT group, 18.9 (3.4-31.2) in the RS group, and 22.1 (2-34.2) in the control group (P < 0.001). The median FSFI total score in the RT group was significantly lower than that in the control group (P < 0.001). Six sexual domains (desire, arousal, lubrication, orgasm, satisfaction, pain) were all significantly affected in the RT group, and no significant differences, except pain, were observed in the RS group as compared with the control group.
  
  
  CONCLUSIONS
  Interventions involving counseling and rehabilitation for female sexual function should be provided in cervical cancer survivors, especially after RT.
authors.affiliation: *Department of Obstetrics and Gynecology and †Clinical Pharmacology and Therapeutics, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Harding
authors.forename: Takuma
authors.initials: T
authors.lastname: Ooyama
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakamoto
authors.forename: Akihiko
authors.initials: A
authors.lastname: Wakayama
authors.forename: Wataru
authors.initials: W
authors.lastname: Kudaka
authors.forename: Morihiko
authors.initials: M
authors.lastname: Inamine
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nagai
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ueda
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Aoki
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008875:Middle Aged; D009017:Morbidity; D009367:Neoplasm Staging; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects*; D012735:Sexual Dysfunction, Physiological / Q000209:etiology*; D019529:Sexuality / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D016387:Women's Health