title: Orexin and orexin receptor like peptides in the gastroenteric tract of Gallus domesticus: An immunohistochemical survey on presence and distribution.
abstract: This study reports the immunohistochemical localization and distribution of orexin A and B-like and their receptors-like peptides in the gastroenteric tract of chicken. The immunoreactivity is distributed in endocrine cells, nerve fibers and neurons, both in the stomach and intestine, and shows a discrete conformity with the data till now reported for Mammals. Our study suggests a possible participation of orexin-like peptides in the modulation of chicken gastroenteric activities and the preservation of their main distribution compared to Mammals. Western blot analysis has confirmed the presence of prepro-orexin and both receptors in the examined tissues. This survey represents the first evidence of the presence of orexin-like peptides in the gastroenteric tract of non mammalian species, and the results could help to better understand the alimentary control and body weight in domestic birds, which are of relevance to determine the productive factors in breeding animals. This study might also serve as a baseline for future experimental studies on the regulation of the gastroenteric functions in non mammalian Vertebrates.
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy. Electronic address: arcamone@unina.it.
authors.forename: N
authors.initials: N
authors.lastname: Arcamone
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy.
authors.forename: L
authors.initials: L
authors.lastname: D'Angelo
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy.
authors.forename: P
authors.initials: P
authors.lastname: de Girolamo
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Lucini
authors.affiliation: Department of Advanced Biomedical Sciences, University of Naples Federico II, Italy; Institute of Biostructures and Bioimages, National Research Council, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pelagalli
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Castaldo
mesh_terms: D000818:Animals; D015153:Blotting, Western / Q000662:veterinary; D002645:Chickens / Q000033:anatomy & histology* / Q000378:metabolism; D005260:Female; D041981:Gastrointestinal Tract / Q000033:anatomy & histology* / Q000378:metabolism; D007150:Immunohistochemistry / Q000662:veterinary; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008297:Male; D009479:Neuropeptides / Q000378:metabolism*; D064446:Orexin Receptors / Q000378:metabolism*; D000068797:Orexins
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D064446:Orexin Receptors; D000068797:Orexins
keywords: Gallus domesticus; Gastroenteric tract; Immunohistochemical study; Orexins; Orexins receptors