title: Chemistry and biology of bengamides and bengazoles, bioactive natural products from Jaspis sponges.
abstract: Sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the bengamides and the bengazoles stand out by virtue of their unprecedented molecular architectures and impressive biological profiles, including antitumor, antibiotic and anthelmintic properties. As a consequence, intense research activity has been devoted to these compounds from both chemical and biological standpoints. This review describes in detail the research into these classes of natural products and the benefits they offer in chemistry and biology.
authors.affiliation: Department of Organic Chemistry, Faculty of Sciences, University of Málaga, Campus de Teatinos s/n., Málaga 29071, Spain. crisgarcia@uma.es.
authors.forename: Cristina
authors.initials: C
authors.lastname: García-Ruiz
authors.affiliation: Department of Organic Chemistry, Faculty of Sciences, University of Málaga, Campus de Teatinos s/n., Málaga 29071, Spain. frsarabia@uma.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Sarabia
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001381:Azepines / Q000737:chemistry* / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D010080:Oxazoles / Q000737:chemistry* / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001381:Azepines; D001688:Biological Products; D007783:Lactones; D010080:Oxazoles