title: [Cytogenetics profiles of renal carcinoma].
abstract: Renal carcinomas are histologically and prognostically heterogeneous. Genomic as well as chromosomal studies of these tumors have permitted a better comprehension of molecular mechanisms implicated in their development and progression. The most frequent histological subtypes are characterized by recurrent cytogenetic abnormalities, such as the loss of the chromosome 3 short arm involving a VHL gene copy in clear cell renal carcinomas, or trisomies 7 and 17 in papillary renal cell carcinomas. New histological subtypes like renal carcinomas associated with Xp11.2 translocations have also been individualized. Besides diagnosis, some chromosomal aberrations like the loss of a short arm of chromosome 9 in different renal carcinoma histological subtypes have a worse prognostic impact. The identification of chromosomal shuffles contributes in backing histological diagnosis and in precising the individual prognosis of patients. This review describes chromosomal abnormalities associated to renal carcinomas and their impact for an accurate classification of these tumors and the evaluation of their prognosis.
authors.affiliation: Service de cytogénétique et biologie cellulaire, hôpital Pontchaillou, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex, France; UMR 6290 IGDR, cancer du rein-BIOSIT, faculté de médecine-Rennes, 35000 Rennes, France.
authors.forename: F
authors.initials: F
authors.lastname: Dugay
authors.affiliation: Service d'anatomie et cytologie pathologiques, CHU de Rennes, 35000 Rennes, France; UMR 6290 IGDR, cancer du rein-BIOSIT, faculté de médecine-Rennes, 35000 Rennes, France.
authors.forename: J
authors.initials: J
authors.lastname: Dagher
authors.affiliation: Service d'urologie, CHU de Rennes, 35000 Rennes, France; UMR 6290 IGDR, cancer du rein-BIOSIT, faculté de médecine-Rennes, 35000 Rennes, France.
authors.forename: G
authors.initials: G
authors.lastname: Verhoest
authors.affiliation: Service de cytogénétique et biologie cellulaire, hôpital Pontchaillou, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Henry
authors.affiliation: Service de cytogénétique et biologie cellulaire, hôpital Pontchaillou, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Jaillard
authors.affiliation: UMR 6290 IGDR, cancer du rein-BIOSIT, faculté de médecine-Rennes, 35000 Rennes, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Arlot-Bonnemains
authors.affiliation: Service d'urologie, CHU de Rennes, 35000 Rennes, France.
authors.forename: K
authors.initials: K
authors.lastname: Bensalah
authors.affiliation: Service de néphrologie, CHU de Rennes, 35000 Rennes, France; UMR 6290 IGDR, cancer du rein-BIOSIT, faculté de médecine-Rennes, 35000 Rennes, France.
authors.forename: C
authors.initials: C
authors.lastname: Vigneau
authors.affiliation: Service d'anatomie et cytologie pathologiques, CHU de Rennes, 35000 Rennes, France; UMR 6290 IGDR, cancer du rein-BIOSIT, faculté de médecine-Rennes, 35000 Rennes, France.
authors.forename: N
authors.initials: N
authors.lastname: Rioux-Leclercq
authors.affiliation: Service de cytogénétique et biologie cellulaire, hôpital Pontchaillou, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex, France; UMR 6290 IGDR, cancer du rein-BIOSIT, faculté de médecine-Rennes, 35000 Rennes, France. Electronic address: marc-antoine.belaud-rotureau@univ-rennes1.fr.
authors.forename: M-A
authors.initials: MA
authors.lastname: Belaud-Rotureau
mesh_terms: D002277:Carcinoma / Q000235:genetics* / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000473:pathology; D020732:Cytogenetic Analysis; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology*
keywords: Carcinome rénal; Caryotype; Cytogenetics; Cytogénétique; Histological subtype; Karyotype; Prognosis; Pronostic; Renal carcinoma; Sous-type histologique