title: Value of multi-detector computed tomography angiography in predicting acute cardiac events in patients with type 2 diabetes.
abstract: The aim of the present study was to investigate the predictive value of multi-detector computed tomography angiography (MDCTA) on acute coronary artery events in patients with type 2 diabetes mellitus (T2DM). MDCTA was performed in 150 patients with T2DM (males, 74; mean age, 66±6.7 years for all patients) that had experienced atypical chest pains. After a follow-up period of at least 2 years, 55 patients were excluded from the study as they did not exhibit any coronary events. The remaining 95 patients were divided into the study group (n=28), that had experienced an acute coronary event such as acute coronary syndrome, or the control group (n=67) that had stable angina. There were no statistically significant differences in the degree of coronary artery lumen stenosis between the study and control groups (P=0.380). The proportion of calcified plaques in the study group was significantly lower compared with the control group (13.6 vs. 53.2%; P<0.001), while the proportion of soft plaques in the study group was significantly higher compared with the control group (37 vs. 9.3%; P<0.001). Type III plaques showed a sensitivity of 76.2% and a negative predictive value of 64.5% for acute coronary events. By contrast, type IV plaques had a sensitivity of 52.6% and a positive predictive value of 63% for chronic coronary events. Therefore, the results of the present study indicate that MDCTA may be used as a noninvasive modality for evaluating and predicting vulnerable coronary atherosclerosis plaques in patients with T2DM.
authors.affiliation: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Daliang
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Radiology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, P.R. China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Jia
authors.affiliation: Central Experimental Laboratory, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Daqing
authors.initials: D
authors.lastname: Ma
authors.affiliation: Central Experimental Laboratory, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, P.R. China.
authors.forename: Guangshan
authors.initials: G
authors.lastname: Tan
authors.affiliation: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: He
authors.affiliation: Department of Radiology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, P.R. China.
authors.forename: Yucun
authors.initials: Y
authors.lastname: Fu
authors.affiliation: School of Biomedical Sciences, Charles Sturt University, Wagga Wagga 2650, Australia.
authors.forename: LE-Xin
authors.initials: LX
authors.lastname: Wang
keywords: acute coronary syndrome; atherosclerotic plaque; diabetes mellitus; multi-detector computed tomography angiography