title: A new megastigmane glycoside from Akebia quinata.
abstract: A new megastigmane glycoside, 8S*,9R*-megastigman-3-one-4,6-diene-8,9-diol-9-O-β-D-glucopyranoside, named akequintoside D (1), as well as six known compounds, roseoside II (2), 3-O-caffeoylquinic acid (3), methyl-3-O-caffeoylquinate (4), 3,4,5-trimethoxyphenyl-β-D-glucopyranoside (5), cuneataside D (6), 3,4-dimethoxyphenyl-6-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside (7) were isolated from the stem of Akebia quinata. The structures of compounds (1-7) were identified based on 1D and 2D NMR, including (1)H-(1)H COSY, HSQC, HMBC and NOESY spectroscopic analyses. The inhibitory activity of these isolated compounds against interleukin-6 (IL-6) production in TNF-α stimulated MG-63 cells was also examined.
authors.affiliation: College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju, 501-759, Republic of Korea.
authors.forename: Hong-Guang
authors.initials: HG
authors.lastname: Jin
authors.forename: A Ryun
authors.initials: AR
authors.lastname: Kim
authors.forename: Hae Ju
authors.initials: HJ
authors.lastname: Ko
authors.forename: Eun-Rhan
authors.initials: ER
authors.lastname: Woo
mesh_terms: D000818:Animals; D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D049917:Dipsacaceae; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D045792:Norisoprenoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems; D051381:Rats; D000093242:Interleukin-6 Inhibitors; D015850:Interleukin-6
chemical_list: D003512:Cyclohexanones; D005960:Glucosides; D006027:Glycosides; D045792:Norisoprenoids; D010936:Plant Extracts; D000093242:Interleukin-6 Inhibitors; C508600:IL6 protein, human; D015850:Interleukin-6; C413264:megastigmane