title: Prematurely delivered rats show improved motor coordination during sensory-evoked motor responses compared to age-matched controls.
abstract: The amount of postnatal experience for perinatal rats was manipulated by delivering pups one day early (postconception day 21; PC21) by cesarean delivery and comparing their motor behavior to age-matched controls on PC22 (the typical day of birth). On PC22, pups were tested on multiple measures of motor coordination: leg extension response (LER), facial wiping, contact righting, and fore- and hindlimb stepping. The LER and facial wiping provided measures of synchronous hind- and forelimb coordination, respectively, and were sensory-evoked. Contact righting also was sensory-evoked and provided a measure of axial coordination. Stepping provided a measure of alternated forelimb and hindlimb coordination and was induced with the serotonin receptor agonist quipazine. Pups that were delivered prematurely and spent an additional day in the postnatal environment showed more bilateral limb coordination during expression of the LER and facial wiping, as well as a more mature righting strategy, compared to controls. These findings suggest that experience around the time of birth shapes motor coordination and the expression of species-typical behavior in the developing rat.
authors.affiliation: Idaho State University, Department of Psychology, Pocatello, ID, United States.
authors.forename: Megan E
authors.initials: ME
authors.lastname: Roberto
authors.affiliation: Idaho State University, Department of Psychology, Pocatello, ID, United States. Electronic address: brummich@isu.edu.
authors.forename: Michele R
authors.initials: MR
authors.lastname: Brumley
mesh_terms: D000818:Animals; D005552:Forelimb / Q000187:drug effects / Q000502:physiology; D007839:Functional Laterality; D006614:Hindlimb / Q000187:drug effects / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D010812:Physical Stimulation; D011187:Posture; D047928:Premature Birth; D011814:Quipazine / Q000494:pharmacology; D017207:Rats, Sprague-Dawley; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
chemical_list: D017366:Serotonin Receptor Agonists; D011814:Quipazine
keywords: Maternal care; Motor development; Neonatal; Postnatal experience; Premature birth