title: Accelerated radiotherapy for T1 to T2 glottic cancer.
abstract: BACKGROUND
  Accelerated fractionation radiotherapy (RT) was administered in an attempt to improve the local control rates in patients with T1/T2 N0 glottic cancer.
  
  
  METHODS
  Medical charts of 148 consecutive patients who had undergone RT using 2.4 Gray (Gy) once-daily fractionation between July 1999 and April 2007 were reviewed.
  
  
  RESULTS
  Of 104 patients with T1 disease treated by RT, 82 received 60 Gy/25 fractions, and the remaining 22 with large tumor volumes and/or slow response to RT received 64.8 Gy/27 fractions. All 44 patients with T2 disease received 64.8 Gy/27 fractions. The 5-year local control and overall survival (OS) rates were 93% and 96%, respectively, in patients with T1 disease, and 77% and 91%, respectively, in patients with T2 disease. No severe acute toxicities were observed, although 2 patients (1%) developed severe late toxicity.
  
  
  CONCLUSIONS
  Accelerated RT for early glottic cancer is feasible, with encouraging local control rates.
authors.affiliation: Division of Radiation Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Motegi
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Kawashima
authors.forename: Satoko
authors.initials: S
authors.lastname: Arahira
authors.forename: Sadamoto
authors.initials: S
authors.lastname: Zenda
authors.forename: Masamichi
authors.initials: M
authors.lastname: Toshima
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Onozawa
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Hayashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Akimoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000517:prevention & control / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D005260:Female; D005931:Glottis; D006258:Head and Neck Neoplasms / Q000517:prevention & control / Q000532:radiotherapy*; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000517:prevention & control / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D016896:Treatment Outcome; D014833:Voice Quality
keywords: accelerated fractionation radiotherapy; adverse events; early glottic cancer; laryngeal preservation; local control