title: Evaluation of left ventricular myocardial perfusion and function using gated SPECT in patients with hypertrophic obstruction cardiomyopathy following percutaneous transluminal septal myocardial ablation.
abstract: OBJECTIVE
  This study was designed to evaluate the left ventricular myocardial perfusion and function in hypertrophic obstruction cardiomyopathy patients following percutaneous transluminal septal myocardial ablation (PTSMA) using rest single-photon emission computed tomography (SPECT) myocardial perfusion imaging.
  
  
  METHODS
  Thirty-five patients (24 men and 11 women, 48±11 years old) with hypertrophic obstruction cardiomyopathy underwent rest-gated Tc-MIBI SPECT imaging 4±10 days before (baseline) and 4.7±1.0 days (short-term) and 15.5±8.2 months (mid-term) after PTSMA. Semiquantitative and QGS quantitative evaluations of perfusion and function were carried out in 17 left ventricular segments.
  
  
  RESULTS
  Myocardial perfusion of the septum following PTSMA was significantly reduced compared with baseline in all patients (P<0.05), but the myocardial perfusion in the basal septum was significantly higher at mid-term compared with short-term following PTSMA (P<0.05). Left ventricular ejection fraction was significantly decreased following PTSMA (P<0.05). Regional wall motion assessed in the basal anterior, basal septum, and basal inferior areas following PTSMA was significantly reduced compared with baseline (P<0.05), and wall thickening of the interventricular septum was decreased following PTSMA (P<0.05).
  
  
  CONCLUSIONS
  Rest-gated SPECT imaging can be used to assess left ventricular myocardial perfusion and function and to investigate the efficacy of PTSMA during follow-up.
authors.affiliation: Departments of aNuclear Medicine bCardiology, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.forename: Shu-Bin
authors.initials: SB
authors.lastname: Qiao
authors.forename: Xiao-Xin
authors.initials: XX
authors.lastname: Sun
authors.forename: Zuo-Xiang
authors.initials: ZX
authors.lastname: He
authors.forename: Yue-Qin
authors.initials: YQ
authors.lastname: Tian
mesh_terms: D055011:Ablation Techniques; D000293:Adolescent; D000328:Adult; D000368:Aged; D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D006346:Heart Septum / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology; D055815:Young Adult