title: Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes.
abstract: The aim of this study was to estimate the effects of oral supplementation of alpha-lipoic acid (ALA) on contrast sensitivity (CS) in patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). The study included 12 patients with T1DM aged 43±12 years, 48 patients with T2DM aged 59±10 years, and 20 control subjects aged 33±8 years. Patients from each studied group, including the control group, were randomly assigned to receive 300 mg of ALA orally once daily for 3 months. CS was evaluated with the Functional Acuity Contrast Test (FACT, Stereo Optical). In the group of patients with T1DM receiving ALA for 3 months CS remained stable and improved in those with T2DM. Reduction of CS in both T1DM and T2DM patients without alpha-lipoic acid supplementation was observed. In the control group on alpha-lipoic acid supplementation, CS improvement was noticed at one spatial frequency. Changes in the CS were observed, despite stable visual acuity and eye fundus image in all studied subjects. Our study demonstrated that oral administration of alpha-lipoic acid had influence on CS in both T1DM and T2DM patients.
authors.affiliation: Department of Ophthalmology, Medical University of Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Gębka
authors.affiliation: Department of Ophthalmology, Medical University of Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, Poland.
authors.forename: Ewelina
authors.identifier: 0000-0002-5928-7056
authors.initials: E
authors.lastname: Serkies-Minuth
authors.affiliation: Department of Ophthalmology, Medical University of Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, Poland ; Department of Anesthesiology and Intensive Care Medicine, Medical University of Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Raczyńska
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage; D016022:Case-Control Studies; D015350:Contrast Sensitivity / Q000187:drug effects*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003941:Diagnostic Techniques, Ophthalmological; D019587:Dietary Supplements; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D008063:Thioctic Acid / Q000008:administration & dosage*; D014792:Visual Acuity
chemical_list: D000975:Antioxidants; D008063:Thioctic Acid