title: Synthesis, thermal and spectroscopic behaviors of metal-drug complexes: La(III), Ce(III), Sm(III) and Y(III) amoxicillin trihydrate antibiotic drug complexes.
abstract: The metal complexes of Amoxicillin trihydrate with La(III), Ce(III), Sm(III) and Y(III) are synthesized with 1:1 (metal:Amox) molar ratio. The suggested formula structures of the complexes are based on the results of the elemental analyses, molar conductivity, (infrared, UV-visible and fluorescence) spectra, effective magnetic moment in Bohr magnetons, as well as the thermal analysis (TG), and characterized by X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The results obtained suggested that Amoxicillin reacted with metal ions as tridentate ligands, coordinating the metal ion through its amino, imino, and β-lactamic carbonyl. The kinetic thermodynamic parameters such as: Ea, ΔH(*), ΔS(*) and ΔG(*) were estimated from the DTG curves.
authors.affiliation: Department of Chemistry, Faculty of Science, Taif University, Al-Hawiah, P.O. Box 888, Taif 21974, Saudi Arabia; Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt. Electronic address: msrefat@yahoo.com.
authors.forename: Moamen S
authors.initials: MS
authors.lastname: Refat
authors.affiliation: Department of Chemistry, Faculty of Science, Sana'a University, Yemen.
authors.forename: Hussein M A
authors.initials: HM
authors.lastname: Al-Maydama
authors.affiliation: Department of Chemistry, Faculty of Science, Sana'a University, Yemen.
authors.forename: Fathi M
authors.initials: FM
authors.lastname: Al-Azab
authors.affiliation: Faculty of Dentistry, Nahda University, Egypt.
authors.forename: Ragab R
authors.initials: RR
authors.lastname: Amin
authors.affiliation: Department of Chemistry, Faculty of Science, Sana'a University, Yemen.
authors.forename: Yasmin M S
authors.initials: YM
authors.lastname: Jamil
mesh_terms: D000658:Amoxicillin / Q000138:chemical synthesis* / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D008670:Metals; D013816:Thermodynamics; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D008670:Metals; D000658:Amoxicillin
keywords: Amoxicillin trihydrate; Antibacterial evaluation; Florescence studies; Spectroscopic studies