title: A perspective review on numerical simulations of hemodynamics in aortic dissection.
abstract: Aortic dissection, characterized by separation of the layers of the aortic wall, poses a significant challenge for clinicians. While type A aortic dissection patients are normally managed using surgical treatment, optimal treatment strategy for type B aortic dissection remains controversial and requires further evaluation. Although aortic diameter measured by CT angiography has been clinically used as a guideline to predict dilation in aortic dissection, hemodynamic parameters (e.g., pressure and wall shear stress), geometrical factors, and composition of the aorta wall are known to substantially affect disease progression. Due to the limitations of cardiac imaging modalities, numerical simulations have been widely used for the prediction of disease progression and therapeutic outcomes, by providing detailed insights into the hemodynamics. This paper presents a comprehensive review of the existing numerical models developed to investigate reasons behind tear initiation and progression, as well as the effectiveness of various treatment strategies, particularly the stent graft treatment.
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering Building, University of Malaya, 50603 Kuala Lumpur, KL, Malaysia.
authors.forename: Wan Naimah
authors.initials: WN
authors.lastname: Wan Ab Naim
authors.affiliation: Department of Mechanical Engineering, Faculty of Engineering Building, University of Malaya, 50603 Kuala Lumpur, KL, Malaysia.
authors.forename: Poo Balan
authors.initials: PB
authors.lastname: Ganesan
authors.affiliation: Discipline of Medical Imaging, Department of Imaging and Applied Physics, Curtin University, Perth, WA 6845, Australia.
authors.forename: Zhonghua
authors.identifier: 0000-0002-7538-4761
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, KL, Malaysia.
authors.forename: Kok Han
authors.identifier: 0000-0002-4485-0504
authors.initials: KH
authors.lastname: Chee
authors.affiliation: Department of Surgery, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, KL, Malaysia.
authors.forename: Shahrul Amry
authors.initials: SA
authors.lastname: Hashim
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering Building, University of Malaya, 50603 Kuala Lumpur, KL, Malaysia.
authors.forename: Einly
authors.identifier: 0000-0003-2037-4213
authors.initials: E
authors.lastname: Lim
mesh_terms: D001014:Aortic Aneurysm / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans