title: Microbiological methods for target-oriented screening of biofilm inhibitors.
abstract: The ability of many pathogenic bacteria to grow as a biofilm results in lower susceptibility to antibiotic treatments and to the host immune response, thus leading to the development of chronic infections. The understanding that biofilms can play an important role in bacterial virulence has prompted the search for inhibitors of biofilm development and of biofilm-related cellular processes. In this report, we present two examples of target-based microbiological screenings for antimicrobials endowed with anti-biofilm activity, aimed respectively at the inhibition of the signal molecule cyclic di-GMP and of quorum sensing.
authors.affiliation: Department of Sciences, Università "Roma Tre", Rome, Italy.
authors.forename: Livia
authors.initials: L
authors.lastname: Leoni
authors.forename: Paolo
authors.initials: P
authors.lastname: Landini
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D053898:Biosynthetic Pathways / Q000187:drug effects; D006152:Cyclic GMP / Q000031:analogs & derivatives / Q000096:biosynthesis; D004353:Drug Evaluation, Preclinical; D008826:Microbial Sensitivity Tests / Q000379:methods*; D053038:Quorum Sensing / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP