title: Inflammation is associated with a worsening of presbycusis: evidence from the MRC national study of hearing.
abstract: OBJECTIVE
  Inflammaging, a state of chronic inflammation in the elderly, is now thought to be a key element of the ageing process and contributor to age-related disease. In a previously published study, we identified a significant association between inflammation levels and severity of presbycusis among individuals aged 63 to 73 ('younger old") within an available audiometric range 0.5 to 4 kHz. Our aim was to see if this association would be identified among participants in the MRC national study of hearing, and whether the strength of the association would increase with greater age, or for very low or very high audiometric frequencies.
  
  
  METHODS
  Cross-sectional analysis of cohort data.
  
  
  METHODS
  Three hundred and sixty community-dwelling adults age 60 years and over, representing all those with white blood cell count and audiometric data available.
  
  
  RESULTS
  A significant independent association between (higher) WBC and (worse) hearing level was identified. This effect increased with age. The strongest association was among those over 75, for whom average hearing threshold levels among those with lower WBC was 17 dB better than those with higher WBC.
  
  
  CONCLUSIONS
  The current findings support an association between inflammaging (a condition potentially amenable to pharmacological treatment or lifestyle management) and presbycusis.
authors.affiliation: * Hearing and Balance Centre, Institute of Sound and Vibration Research, University of Southampton , Highfield, Southampton , UK.
authors.forename: Carl
authors.initials: C
authors.lastname: Verschuur
authors.forename: Akosua
authors.initials: A
authors.lastname: Agyemang-Prempeh
authors.forename: Tracey A
authors.initials: TA
authors.lastname: Newman
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011304:Presbycusis / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D015995:Prevalence; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology
keywords: Presbycusis; age-related hearing loss; bio-markers; inflammation