title: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) and proteolytic processing by a disintegrin and metalloproteinases (ADAM): a regulator of several pathways.
abstract: HB-EGF is a member of the EGF family of ligands that is initially synthesized as a membrane-bound growth factor termed, proHB-EGF. The membrane bound proHB-EGF undergoes extensive proteolytic processing by several metalloproteinases capable of stimulating cellular proliferation. Soluble, mature HB-EGF binds to and activates EGF receptors. HB-EGF is a critical molecular component to a number of normal physiological processes including but not limited to tissue injury and wound healing, reproduction, angiogenesis and recently, adipogenesis. Misexpression of HB-EGF is linked to tumor formation and cancer including hepatocellular, pancreatic, gastric, breast, colon and melanoma, gliomas and glioblastomas. HB-EGF is a likely tool for therapeutic approaches to enhance treatment of injuries as well as a target for prevention of several cancers and obesity.
authors.affiliation: Department of Biology, Miami University, Oxford, OH 45056, United States.
authors.forename: S R
authors.initials: SR
authors.lastname: Taylor
authors.affiliation: Department of Biology, Miami University, Oxford, OH 45056, United States.
authors.forename: M G
authors.initials: MG
authors.lastname: Markesbery
authors.affiliation: Department of Biology, Miami University, Oxford, OH 45056, United States. Electronic address: hardinpa@miamioh.edu.
authors.forename: P A
authors.initials: PA
authors.lastname: Harding
mesh_terms: D000818:Animals; D019483:Disintegrins / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066257:Heparin-binding EGF-like Growth Factor / Q000378:metabolism*; D006801:Humans; D045726:Metalloproteases / Q000378:metabolism*; D009024:Morphogenesis / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
chemical_list: D019483:Disintegrins; D066257:Heparin-binding EGF-like Growth Factor; D004815:Epidermal Growth Factor; D045726:Metalloproteases
keywords: ADAM; Adipogenesis; Angiogenesis; HB-EGF; HB-EGF processing; Reproductive biology; Transgenic mice; Tumor formation; Wound healing