title: Association between APE1 Single Nucleotide Polymorphism (rs1760944) and Cancer Risk: a Meta-Analysis Based on 6,419 Cancer Cases and 6,781 Case-free Controls.
abstract: Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential enzyme in the base excision repair pathway. Epidemiological studies have suggested associations between APE1 rs1760944 polymorphism and cancer risk. This study was aimed to evaluate the relationship between APE1 rs1760944 polymorphism and cancer risk. We searched Pubmed, ISI Web of Knowledge, Embase, Chinese National Knowledge Infrastructure (CNKI) databases until September 2013 to identify eligible studies. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to estimate the strength of the associations. 12 studies from 11 articles on APE1 rs1760944 genotypes and cancer risk were identified, including a total of 6,419 cancer cases and 6,781 case-free controls. Overall, APE1 rs1760944 polymorphism was significantly associated with the decreased risk of cancer in any genetic models (G vs. T: OR = 0.86, 95% CI = 0.82-0.90; homozygote comparison: OR = 0.74, 95% CI = 0.67-0.82; heterozygote comparison: OR =0.88, 95%CI = 0.81-0.95; dominant model TG+GG vs. TT: OR = 0.82, 95% CI = 0.76-0.89; recessive model GG vs. TT+TG: OR = 0.81, 95%CI = 0.75-0.88). In the stratified analysis by populations, the effect was remain in studies of Asian population (homozygote comparison: OR = 0.71, 95%CI = 0.63-0.79; heterozygote comparison: OR = 0.86, 95 %CI = 0.79- 0.94; dominant model: OR = 0.80, 95% CI = 0.74 -0.87 and recessive model: OR = 0.78, 95%CI = 0.71-0.86). Moreover, a significantly decreased risk was found in lung cancer studies (homozygote comparison: OR = 0.68, 95% CI = 0.59-0.79; heterozygote comparison: OR = 0.86, 95%CI = 0.77- 0.98; dominant model: OR = 0.80, 95%CI = 0.72-0.90 and recessive model: OR= 0.77, 95% CI= 0.68-0.87). These findings support that APE1 rs1760944 polymorphism has a possible protective effect on cancer susceptibility particularly among Asians. Further studies based on different ethnicity and various cancer types are warranted to verify our findings.
authors.affiliation: 1. Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China;
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Dai
authors.affiliation: 1. Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China;
authors.forename: Xi-Jing
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: 2. Department of Pathology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China;
authors.forename: An-Jing
authors.initials: AJ
authors.lastname: Kang
authors.affiliation: 1. Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China;
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Ma
authors.affiliation: 1. Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China;
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Min
authors.affiliation: 1. Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China;
authors.forename: Shuai
authors.initials: S
authors.lastname: Lin
authors.affiliation: 1. Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China;
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: 1. Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China;
authors.forename: Peng-Tao
authors.initials: PT
authors.lastname: Yang
authors.affiliation: 1. Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China;
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: 1. Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China;
authors.forename: Hua-Feng
authors.initials: HF
authors.lastname: Kang
keywords: APE1; cancer susceptibility; meta-analysis.; single nucleotide polymorphism