title: Whole-genome sequencing in newborn screening programs.
abstract: The availability of whole-genome sequencing (WGS) is likely to change the practice of population screening programs such as newborn screening (NBS). This Commentary raises key ethical, legal, and social issues surrounding WGS in NBS and suggests a need for deliberation regarding the policy challenges of introducing sequencing in such programs. Any change in the goals of NBS programs should be discussed carefully and should represent the best interests of the child.
authors.affiliation: Department of Human Genetics, McGill University, Montreal, Quebec H3A OG1, Canada.
authors.forename: Bartha M
authors.initials: BM
authors.lastname: Knoppers
authors.forename: Karine
authors.initials: K
authors.lastname: Sénécal
authors.forename: Pascal
authors.initials: P
authors.lastname: Borry
authors.forename: Denise
authors.initials: D
authors.lastname: Avard
mesh_terms: D015894:Genome, Human / Q000235:genetics*; D006291:Health Policy; D006801:Humans; D007231:Infant, Newborn; D009154:Mutation / Q000235:genetics; D015997:Neonatal Screening / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*