title: Limitation of HIF-1α with pentoxifillyne on renal tubular ischemia result of hiperoxaluria and ESWL.
abstract: OBJECTIVE
  To evaluate hypoxia-inducible factor 1 subunit α (HIF-1α) expression during the performance of extracorporeal shock wave lithotripsy (ESWL) and to investigate the effects of pentoxyphylline on HIF-1α expression.
  
  
  METHODS
  One hundred New Zealand Albino rabbit were used in the study divided in 5 groups. There were 20 rabbits in each group. The groups were divided in two parts: early (7 days) and late period (14 days) according to follow up duration. Immunohistochemical analyses were performed using nuclear staining to show HIF-1α expression in rabbit renal tissue sample.
  
  
  RESULTS
  HIF-1α expression was higher in rabbits undergoing ESWL (group 4). In the hyperoxaluria group taking pentoxyphylline before ESWL (group 5), HIF-1α expression was lower in both early and late period subgroups (p < 0.05) CONCLUSION: In this study we evaluated HIF-1α expression and showed that ESWL may cause renal cell injury. Our results suggest that pentoxyphylline, as a circulatory regulator agent, may prevent renal cell injury induced by ESWL.
authors.affiliation: Department of Urology. Department of Anatomopathology. Gaziantep University. Gaziantep. Turkey.
authors.forename: Sakip
authors.initials: S
authors.lastname: Erturhan
authors.forename: Omer
authors.initials: O
authors.lastname: Bayrak
authors.forename: Ilker
authors.initials: I
authors.lastname: Seckiner
authors.forename: Mehmet
authors.initials: M
authors.lastname: Celik
authors.forename: Metin
authors.initials: M
authors.lastname: Karakok
mesh_terms: D000818:Animals; D006959:Hyperoxaluria / Q000209:etiology*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000096:biosynthesis*; D007668:Kidney / Q000378:metabolism; D007684:Kidney Tubules / Q000187:drug effects* / Q000378:metabolism; D008096:Lithotripsy / Q000009:adverse effects*; D010431:Pentoxifylline / Q000494:pharmacology*; D011817:Rabbits; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D014665:Vasodilator Agents; D010431:Pentoxifylline