title: Distinct origins of dura mater graft-associated Creutzfeldt-Jakob disease: past and future problems.
abstract: Dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) can be divided into two subgroups that exhibit distinct clinical and neuropathological features, with the majority represented by a non-plaque-type of dCJD (np-dCJD) and the minority by a plaque-type of dCJD (p-dCJD). The two distinct phenotypes of dCJD had been considered to be unrelated to the genotype (methionine, M or valine, V) at polymorphic codon 129 of the PRNP gene or type (type 1 or type 2) of abnormal isoform of prion protein (PrPSc) in the brain, while these are major determinants of clinicopathological phenotypes of sporadic CJD (sCJD). The reason for the existence of two distinct subgroups in dCJD had remained elusive. Recent progress in research of the pathogenesis of dCJD has revealed that two distinct subgroups of dCJD are caused by infection with different PrPSc strains from sCJD, i.e., np-dCJD caused by infection with sCJD-MM1/MV1, and p-dCJD caused by infection with sCJD-VV2 or -MV2. These studies have also revealed previously unrecognized problems as follows: (i) the numbers of p-dCJD patients may increase in the future, (ii) the potential risks of secondary infection from dCJD, particularly from p-dCJD, may be considerable, and (iii) the effectiveness of the current PrPSc decontamination procedures against the PrPSc from p-dCJD is uncertain. To prevent secondary infection from p-dCJD, the establishment of effective decontamination procedures is an urgent issue. In this review, we summarize the past and future problems surrounding dCJD.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Matsuura
authors.forename: Shirou
authors.initials: S
authors.lastname: Mohri
authors.affiliation: Department of Neurological Science, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. kitamoto@med.tohoku.ac.jp.
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Kitamoto
mesh_terms: D000818:Animals; D016380:Brain Tissue Transplantation / Q000009:adverse effects*; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology* / Q000209:etiology*; D004388:Dura Mater / Q000601:surgery / Q000637:transplantation / Q000821:virology; D006801:Humans