title: In vitro response of tracheal smooth muscle from hyperresponsive guinea pigs to celiprolol.
abstract: BACKGROUND
  The use of beta-blockers is limited by adverse effects such as bronchospasm in asthmatics. Third generation beta-blockers such as celiprolol may show better respiratory tolerability because they lack beta-blocker induced broncho-constriction.
  
  
  METHODS
  Effect of celiprolol on the histamine induced contraction of tracheal muscle strips prepared from ovalbumin-sensitised guinea pigs was studied. Using oxygenated Krebs-Henseleit solution as the nutrient medium, the trachealis muscle activity was measured with isometric force displacement transducer and recorded on 4-channel Oscillograph.
  
  
  RESULTS
  Celiprolol 10(-4) M shifted the concentration-response curve of histamine downwards and to the right. Mean of amplitude of contraction, percent responses and deviations when compared with the control group were significantly different (p < 0.05).
  
  
  CONCLUSIONS
  Celiprolol antagonised histamine-induced contractions of tracheal muscle of guinea pigs. So it may be considered safe in patients with asthma. However, further clinical evaluation and exploratory work is required.
authors.forename: Asma
authors.initials: A
authors.lastname: Shaukat
authors.forename: Sumera
authors.initials: S
authors.lastname: Kazmi
authors.forename: Robina
authors.initials: R
authors.lastname: Shaheen
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000494:pharmacology*; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D017272:Celiprolol / Q000494:pharmacology*; D004195:Disease Models, Animal; D006168:Guinea Pigs; D009130:Muscle, Smooth / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects*
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D017272:Celiprolol