title: Patterns of cortical thinning in idiopathic rapid eye movement sleep behavior disorder.
abstract: Idiopathic rapid eye movement sleep behavior disorder is a parasomnia that is a risk factor for dementia with Lewy bodies and Parkinson's disease. Brain function impairments have been identified in this disorder, mainly in the frontal and posterior cortical regions. However, the anatomical support for these dysfunctions remains poorly understood. We investigated gray matter thickness, gray matter volume, and white matter integrity in patients with idiopathic rapid eye movement sleep behavior disorder. Twenty-four patients with polysomnography-confirmed idiopathic rapid eye movement sleep behavior disorder and 42 healthy individuals underwent a 3-tesla structural and diffusion magnetic resonance imaging examination using corticometry, voxel-based morphometry, and diffusion tensor imaging. In the patients with idiopathic rapid eye movement sleep behavior disorder, decreased cortical thickness was observed in the frontal cortex, the lingual gyrus, and the fusiform gyrus. Gray matter volume was reduced in the superior frontal sulcus only. Patients showed no increased gray matter thickness or volume. Diffusion tensor imaging analyses revealed no significant white matter differences between groups. Using corticometry in patients with idiopathic rapid eye movement sleep behavior disorder, several new cortical regions with gray matter alterations were identified, similar to those reported in dementia with Lewy bodies and Parkinson's disease. These findings provide some anatomical support for previously identified brain function impairments in this disorder.
authors.affiliation: Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada; Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.
authors.forename: Shady
authors.initials: S
authors.lastname: Rahayel
authors.forename: Jacques
authors.initials: J
authors.lastname: Montplaisir
authors.forename: Oury
authors.initials: O
authors.lastname: Monchi
authors.forename: Christophe
authors.initials: C
authors.lastname: Bedetti
authors.forename: Ronald B
authors.initials: RB
authors.lastname: Postuma
authors.forename: Simona
authors.initials: S
authors.lastname: Brambati
authors.forename: Julie
authors.initials: J
authors.lastname: Carrier
authors.forename: Sven
authors.initials: S
authors.lastname: Joubert
authors.forename: Véronique
authors.initials: V
authors.lastname: Latreille
authors.forename: Thomas
authors.initials: T
authors.lastname: Jubault
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Gagnon
mesh_terms: D000368:Aged; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D020187:REM Sleep Behavior Disorder / Q000473:pathology*
keywords: cortical thickness; diffusion tensor imaging; neurodegenerative diseases; rapid eye movement sleep behavior disorder; voxel-based morphometry