title: Anti dermatophytic therapy--prospects for the discovery of new drugs from natural products.
abstract: Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these infections is often toxic, long-term, and expensive and has limited effectiveness; therefore, the discovery of new anti dermatophytic compounds is a necessity. Natural products have been the most productive source for new drug development. This paper provides a brief review of the current literature regarding the presence of dermatophytes in immunocompromised patients, drug resistance to conventional treatments and new anti dermatophytic treatments.
authors.affiliation: Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio Mesquita Filho", Araraquara, SP, Brazil.
authors.forename: Luciana Arantes
authors.initials: LA
authors.lastname: Soares
authors.affiliation: Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio Mesquita Filho", Araraquara, SP, Brazil.
authors.forename: Janaína
authors.initials: J
authors.lastname: de Cássia Orlandi Sardi
authors.affiliation: Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio Mesquita Filho", Araraquara, SP, Brazil.
authors.forename: Fernanda Patrícia
authors.initials: FP
authors.lastname: Gullo
authors.affiliation: Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio Mesquita Filho", Araraquara, SP, Brazil.
authors.forename: Nayla
authors.initials: N
authors.lastname: de Souza Pitangui
authors.affiliation: Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio Mesquita Filho", Araraquara, SP, Brazil.
authors.forename: Liliana
authors.initials: L
authors.lastname: Scorzoni
authors.affiliation: Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio Mesquita Filho", Araraquara, SP, Brazil.
authors.forename: Fernanda Sangalli
authors.initials: FS
authors.lastname: Leite
authors.affiliation: Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio Mesquita Filho", Araraquara, SP, Brazil.
authors.forename: Maria José Soares Mendes
authors.initials: MJ
authors.lastname: Giannini
authors.affiliation: Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio Mesquita Filho", Araraquara, SP, Brazil.
authors.forename: Ana Marisa Fusco
authors.initials: AM
authors.lastname: Almeida
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D003883:Arthrodermataceae / Q000187:drug effects; D001688:Biological Products / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D055808:Drug Discovery / Q000639:trends*; D006801:Humans; D014005:Tinea / Q000188:drug therapy* / Q000453:epidemiology*
chemical_list: D000935:Antifungal Agents; D001688:Biological Products
keywords: dermatophytes; filamentous fungi; natural products; synthetic product