title: [Type 2 autoimmune polyendocrine syndromes (APS-2)].
abstract: Type 2 autoimmune polyendocrine syndromes (APS-2) are the most frequent disorders associating several organ-specific autoimmune diseases. Their high prevalence is due to the fact that the main manifestations of APS-2, such as thyroidal autoimmunity, type 1 diabetes, autoimmune gastric atrophy and vitiligo, are common diseases. APS-2 represents a clinical model that can serve to help unravel the mechanisms underlying autoimmunity. Diagnosis of APS-2 is a challenge for the clinician, especially in poorly symptomatic forms, and may require systematic screening based on measurement of autoantibodies and functional markers.
authors.forename: Bernard
authors.initials: B
authors.lastname: Vialettes
authors.forename: Noémie
authors.initials: N
authors.lastname: Dubois-Leonardon
mesh_terms: D015551:Autoimmunity / Q000502:physiology; D015415:Biomarkers; D004777:Environment; D020022:Genetic Predisposition to Disease; D006801:Humans; D008403:Mass Screening; D016884:Polyendocrinopathies, Autoimmune / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors
chemical_list: D015415:Biomarkers