title: An inactivated oil-emulsion fowl Adenovirus serotype 4 vaccine provides broad cross-protection against various serotypes of fowl Adenovirus.
abstract: The number of clinical cases of inclusion body hepatitis (IBH) and hydropericardium-hepatitis syndrome (HHS) has been increasing, resulting in considerable economic losses in many countries. Currently, only fowl Adenovirus (FAdV) serotype 4 (FAdV-4) has been reported as the causative agent of HHS, whereas IBH can be caused by all 12 serotypes of FAdV. For protection against HHS, various live and killed FAdV serotype 4 vaccines have been developed. However, there is a concern whether these vaccines composed of FAdV-4 alone could provide protection against IBH, which is caused by other serotypes of virulent FAdVs. To date, there have been no reports evaluating the protective efficacy of the FAdV-4 vaccine against other serotypes of FAdV. Thus, we investigated the cross-protection efficacy of an inactivated oil-emulsion FAdV-4 vaccine against various serotypes of FAdV field isolates. Our study demonstrated that the inactivated oil-emulsion FAdV-4 vaccine could provide broad cross-protection against various serotypes of FAdV in not only vaccinated birds, but also the progenies of vaccinated breeder. Therefore, we conclude that the inactivated oil-emulsion FAdV-4 vaccine could be effective in preventing the spread of various other serotypes of FAdV as well as FAdV-4 infection in the poultry industry.
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors.forename: Myeong-Seob
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Lim
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors.forename: Dong-Hun
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors.forename: Ha-Na
authors.initials: HN
authors.lastname: Youn
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors.forename: Seong-Su
authors.initials: SS
authors.lastname: Yuk
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors.forename: Byoung-Yoon
authors.initials: BY
authors.lastname: Kim
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors.forename: Soo-Won
authors.initials: SW
authors.lastname: Choi
authors.affiliation: KBNP Technology Institute, 254-18, Dugok-Ri, Sinam, Yesan, Republic of Korea.
authors.forename: Cheong-Hwan
authors.initials: CH
authors.lastname: Jung
authors.affiliation: KBNP Technology Institute, 254-18, Dugok-Ri, Sinam, Yesan, Republic of Korea.
authors.forename: Jang-Hyuck
authors.initials: JH
authors.lastname: Han
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea. Electronic address: songcs@konkuk.ac.kr.
authors.forename: Chang-Seon
authors.initials: CS
authors.lastname: Song
mesh_terms: D000257:Adenoviridae Infections / Q000517:prevention & control*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D000259:Aviadenovirus / Q000145:classification; D002645:Chickens; D056738:Cross Protection; D006524:Hepatitis, Viral, Animal / Q000517:prevention & control; D011201:Poultry Diseases / Q000517:prevention & control*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines
keywords: Chicken; Cross-protection; Fowl adenovirus; Serotype; Vaccine