title: Assessment of tumor size as a useful marker for the surgical staging of endometrial cancer.
abstract: Accumulating evidence suggests that the estimation of tumor size may improve endometrial cancer treatment. We conducted an observational study aimed at elucidating the association between tumor size and other universally accepted prognostic factors in order to identify suitable preoperative parameters which can guide surgery in a subgroup of early corpus endometrial cancer. We found that when tumor size increased, both stage and grading were significantly increased. Tumor size was correlated with CA 125 serum values, node metastasis and peritoneal cytology status. Patients who have grade 1 or 2 endometrioid corpus cancer, myometrial invasion < 50% and ≤ 3 cm largest tumor diameter can only be treated with hysterectomy. The tumor largest diameter should be evaluated as a preoperative parameter that indicates patients who do not require lymphadenectomy.
authors.affiliation: Department of Surgical Sciences, University of Parma, Parma, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Berretta
authors.affiliation: Department of Surgical Sciences, University of Parma, Parma, Italy.
authors.forename: Tito Silvio
authors.initials: TS
authors.lastname: Patrelli
authors.affiliation: Department of Surgical Sciences, University of Parma, Parma, Italy.
authors.forename: Costanza
authors.initials: C
authors.lastname: Migliavacca
authors.affiliation: Department of Surgical Sciences, University of Parma, Parma, Italy.
authors.forename: Martino
authors.initials: M
authors.lastname: Rolla
authors.affiliation: Department of Surgical Sciences, University of Parma, Parma, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Franchi
authors.affiliation: Department of Surgical Sciences, University of Parma, Parma, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Monica
authors.affiliation: Department of Surgical Sciences, University of Parma, Parma, Italy.
authors.forename: Alberto Bacchi
authors.initials: AB
authors.lastname: Modena
authors.affiliation: Department of Women and Child Health, University of Padua, Padua, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gizzo
mesh_terms: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen / Q000097:blood; D018269:Carcinoma, Endometrioid / Q000601:surgery; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008565:Membrane Proteins / Q000097:blood; D009367:Neoplasm Staging; D012189:Retrospective Studies; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins