title: An Insight in to Paget's Disease of Bone.
abstract: Paget's disease of bone (PDB) is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. PDB is a focal disorder of bone turnover characterized by excessive bone resorption coupled with bone formation. PDB begins with a period of increased osteoclastic activity and bone resorption, followed by increased osteoblast production of woven bone that is poorly mineralized. In the final phase of the disease process, dense cortical and trabecular bone deposition predominates, but the bone is sclerotic and poorly organized and lacks the structural integrity and strength of normal bone. This article briefly reviews the etiopathogenesis, clinical radiographic and histological features of Paget's disease.
authors.affiliation: Department of Oral Pathology and Microbiology, Bhojia Dental College and Hospital, Baddi, India.
authors.forename: Robin
authors.initials: R
authors.lastname: Sabharwal
authors.affiliation: Department of Periodontology, DJ College of Dental Sciences and Research, Modinagar, Uttar Pradesh, India.
authors.forename: Shivangi
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Himachal Dental College and Hospital, Sundernagar, India.
authors.forename: Shipra
authors.initials: S
authors.lastname: Sepolia
authors.affiliation: Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bhubneshwar, India.
authors.forename: Rajat
authors.initials: R
authors.lastname: Panigrahi
authors.affiliation: Department of Conservative Dentistry, Institute of Dental Sciences, Bhubneshwar, India.
authors.forename: Saumyakanta
authors.initials: S
authors.lastname: Mohanty
authors.affiliation: Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Bhubneshwar, India.
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Subudhi
authors.affiliation: Department of Oral Pathology and Microbiology, MMCDSR, Ambala, India.
authors.forename: Manish
authors.initials: M
authors.lastname: Kumar
keywords: Osteoclast; osteoprotegerin; receptor activator of NF-κB; receptor activator of NF-κB ligand