title: Change in serum CXCL10 levels during anti-tuberculosis treatment depends on vitamin D status [Short Communication].
abstract: Serum levels of the inflammatory C-X-C motif chemokine 10 (CXCL10) are raised in tuberculosis (TB). CXCL10 gene expression is downregulated in monocytes by metabolically active vitamin D3 (1,25dihydroxy vitamin D). Stratification of patients by serum 25hydroxyvitamin D (25[OH]D) levels at baseline showed that treatment-induced decrease in CXCL10 occurred in those with 'insufficient' and 'deficient' but not in those with 'optimal' levels. In the deficient group, 25(OH)D showed an inverse correlation with CXCL10 levels. CXCL10 may thus be a useful biomarker for the follow-up of response to treatment. However, CXCL10 levels should be interpreted taking into account the baseline serum vitamin D levels of the TB patients.
authors.affiliation: Department of Pathology and Microbiology, the Aga Khan University, Karachi, Pakistan.
authors.forename: Z
authors.initials: Z
authors.lastname: Hasan
authors.affiliation: Department of Medicine, the Aga Khan University, Karachi, Pakistan.
authors.forename: N
authors.initials: N
authors.lastname: Salahuddin
authors.affiliation: Ojha Institute for Chest Diseases, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: N
authors.initials: N
authors.lastname: Rao
authors.affiliation: Department of Medicine, the Aga Khan University, Karachi, Pakistan.
authors.forename: M
authors.initials: M
authors.lastname: Aqeel
authors.affiliation: Department of Medicine, the Aga Khan University, Karachi, pakistan.
authors.forename: F
authors.initials: F
authors.lastname: Mahmood
authors.affiliation: Department of Medicine, the Aga Khan University, Karachi, Pakistan.
authors.forename: F
authors.initials: F
authors.lastname: Ali
authors.affiliation: Department of Pathology and Microbiology, the Aga Khan University, Karachi, Pakistan.
authors.forename: M
authors.initials: M
authors.lastname: Ashraf
authors.affiliation: Department of Medicine, the Aga Khan University, Karachi, Pakistan.
authors.forename: F
authors.initials: F
authors.lastname: Rahman
authors.affiliation: Department of Pathology and Microbiology, the Aga Khan University, Karachi, Pakistan.
authors.forename: S
authors.initials: S
authors.lastname: Mahmood
authors.affiliation: Department of Pathology and Microbiology, the Aga Khan University, Karachi, Pakistan.
authors.forename: M
authors.initials: M
authors.lastname: Islam
authors.affiliation: Department of Medicine, the Aga Khan University, Karachi, Pakistan.
authors.forename: B
authors.initials: B
authors.lastname: Dildar
authors.affiliation: Ojha Institute for Chest Diseases, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: T
authors.initials: T
authors.lastname: Anwer
authors.affiliation: Department of Medicine, the Aga Khan University, Karachi, pakistan.
authors.forename: F
authors.initials: F
authors.lastname: Oiighor
authors.affiliation: Department of Medicine, the Aga Khan University, Karachi, Pakistan.
authors.forename: N
authors.initials: N
authors.lastname: Sharif
authors.affiliation: Department of Medicine, the Aga Khan University, Karachi, Pakistan.
authors.forename: A R
authors.initials: AR
authors.lastname: Ullah
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D054357:Chemokine CXCL10 / Q000097:blood*; D006801:Humans; D016896:Treatment Outcome; D014376:Tuberculosis / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000175:diagnosis
chemical_list: D000995:Antitubercular Agents; D015415:Biomarkers; C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; D014807:Vitamin D; C104450:25-hydroxyvitamin D