title: Metabolic interactions between vitamin A and conjugated linoleic acid.
abstract: Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner. Dietary conjugated linoleic acid (CLA) is a fatty acid with a conjugated diene structure that is found in low concentrations in ruminant products and available as a nutritional supplement. CLA has been shown to increase tissue levels of retinol (vitamin A alcohol) and its sole specific circulating carrier protein retinol-binding protein (RBP or RBP4). However, the precise mechanism of this action has not been elucidated yet. Here, we provide a summary of the current knowledge in this specific area of research and speculate that retinol and CLA may compete for catabolic pathways modulated by the activity of PPAR-α and RXR heterodimer. We also present preliminary data that may position PPAR-α at the crossroads between the metabolism of lipids and vitamin A.
authors.affiliation: Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554, km. 4500, Monserrato, Cagliari 09042, Italy. giacarta28@hotmail.com.
authors.forename: Gianfranca
authors.initials: G
authors.lastname: Carta
authors.affiliation: Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554, km. 4500, Monserrato, Cagliari 09042, Italy. m.elisabetta.murru@gmail.com.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Murru
authors.affiliation: Department of Bioscience and Nutrition, Karolinska Institute, Stockholm 141 83, Sweden. lina_c@hotmail.it.
authors.forename: Lina
authors.initials: L
authors.lastname: Cordeddu
authors.affiliation: Gerstner Sloan-Kettering Graduate School in Biomedical Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. OrtizB@mskcc.org.
authors.forename: Berenice
authors.initials: B
authors.lastname: Ortiz
authors.affiliation: Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM + CSIC, Madrid 28049, Spain. elen79@yahoo.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Giordano
authors.affiliation: Department of Human Nutrition, Ohio State University, Columbus, OH 43210, USA. belury.1@osu.edu.
authors.forename: Martha A
authors.initials: MA
authors.lastname: Belury
authors.affiliation: Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA. quadro@AESOP.Rutgers.edu.
authors.forename: Loredana
authors.initials: L
authors.lastname: Quadro
authors.affiliation: Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554, km. 4500, Monserrato, Cagliari 09042, Italy. banni@unica.it.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Banni
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D019587:Dietary Supplements; D004347:Drug Interactions; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism; D012177:Retinol-Binding Proteins / Q000235:genetics / Q000378:metabolism; D014801:Vitamin A / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D044243:Linoleic Acids, Conjugated; D047493:PPAR alpha; D012177:Retinol-Binding Proteins; D014801:Vitamin A