title: Regeneration-associated genes on optic nerve regeneration in fish retina.
abstract: It has been well documented that fish central nervous system, including retina and optic nerve, can regenerate and recover its function after nerve injury. Within a few decades, a number of regeneration-associated genes (RAGs) have been identified in fish retina following optic nerve injury (ONI). RAGs can be classified into two groups: cell survival- and axonal outgrowth-related genes. In fish retina after ONI, cell survival-related genes were upregulated in 1-6 days after ONI, which corresponds to the preparation stage for cell survival and axonal sprouting. Subsequently, axonal outgrowth-related genes were upregulated in 1-6 weeks after ONI, which corresponds to the axonal regrowth stage. Recently, we've found a novel type of RAGs, dedifferentiation-related genes, that are upregulated in overlapping time between cell survival and axonal regrowth (3-10 days after ONI). In this chapter we summarize these three types of RAGs that promote optic nerve regeneration in the fish retina after ONI.
authors.affiliation: Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5-11-80 Kodatsuno, 920-0942, Kanazawa, Ishikawa, Japan, kazu0208@stu.kanazawa-u.ac.jp.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ogai
authors.forename: Maki
authors.initials: M
authors.lastname: Nishitani
authors.forename: Ayaka
authors.initials: A
authors.lastname: Kuwana
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Mawatari
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Koriyama
authors.forename: Kayo
authors.initials: K
authors.lastname: Sugitani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakashima
authors.forename: Satoru
authors.initials: S
authors.lastname: Kato
mesh_terms: D000818:Animals; D054337:Cell Dedifferentiation / Q000235:genetics; D002470:Cell Survival / Q000502:physiology; D005399:Fishes / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D009416:Nerve Regeneration / Q000235:genetics*; D009900:Optic Nerve / Q000166:cytology / Q000502:physiology*; D020221:Optic Nerve Injuries / Q000235:genetics / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000502:physiology*