title: [Complete diagnostic work-up provides the rational basis for the most appropriate therapy of myelodysplastic syndromes].
abstract: Myelodysplastic syndromes are now classified according to the 2008 World Health Organization criteria. An accurate risk assessment requires a keen evaluation of disease-related factors to adapt treatment to patients age, expectations and comorbidities. A high proportion of MDS patients are not eligible for potentially curative and consequently intensive treatment because of advanced age and/or clinically relevant comorbidities and poor performance status. In these patients, a number of new agents are available or being developed but their use should be carefully guided by the chromosomal and genetic determinant of the disease.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Pane
mesh_terms: D000367:Age Factors; D015897:Comorbidity; D015195:Drug Design; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000145:classification / Q000175:diagnosis* / Q000628:therapy; D018570:Risk Assessment; D012307:Risk Factors; D014944:World Health Organization