title: Experience with a gonadotrophin-releasing hormone agonist prior to myomectomy--comparison of twice- vs thrice-monthly doses and a control group.
abstract: The aim of this randomised prospective study was to investigate the impact of preoperative gonadotrophin-releasing hormone agonist (GnRHa) compared with a control group with myomectomy. A total of 36 women (n = 36, group 1) with fibroids were randomised to receive either two monthly doses (n = 18/36, group 1a) or three monthly doses of goserelin (n = 18/36, group 1b) prior to myomectomy. The 32 women who received no treatment (group 2) comprised the controls. All patients had similar demographic features. There were no significant differences among the three groups with respect to: (1) mean intraoperative blood loss; (2) preoperative and postoperative blood transfusion or (3) length of hospital stay. The only advantage of administering GnRHa prior to myomectomy for symptomatic fibroids in our population was a higher haemoglobin level prior to surgery among the women who received three doses of the drug.
authors.affiliation: Department of Obstetrics and Gynaecology, Mt. Hope Maternity Hospital , Trinidad , West Indies.
authors.forename: B
authors.initials: B
authors.lastname: Bassaw
authors.forename: N
authors.initials: N
authors.lastname: Mohammed
authors.forename: A
authors.initials: A
authors.lastname: Jaggat
authors.forename: M
authors.initials: M
authors.lastname: Singh-Bhola
authors.forename: A
authors.initials: A
authors.lastname: Ramkissoon
authors.forename: P
authors.initials: P
authors.lastname: Singh
authors.forename: K
authors.initials: K
authors.lastname: Jones
authors.forename: S
authors.initials: S
authors.lastname: Maharaj
authors.forename: S
authors.initials: S
authors.lastname: Ramsewak
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D004334:Drug Administration Schedule; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D017273:Goserelin / Q000008:administration & dosage*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy* / Q000601:surgery; D007902:Length of Stay; D011300:Preoperative Care; D011446:Prospective Studies; D063186:Uterine Myomectomy; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D018931:Antineoplastic Agents, Hormonal; D006454:Hemoglobins; D017273:Goserelin; D007987:Gonadotropin-Releasing Hormone
keywords: Blood loss; GnRHa; blood transfusion; complications; myomectomy