title: Incidence rates and trends of hip/femur fractures in five European countries: comparison using e-healthcare records databases.
abstract: Hip fractures represent a major public health challenge worldwide. Multinational studies using a common methodology are scarce. We aimed to estimate the incidence rates (IRs) and trends of hip/femur fractures over the period 2003-2009 in five European countries. The study was performed using seven electronic health-care records databases (DBs) from Denmark, The Netherlands, Germany, Spain, and the United Kingdom, based on the same protocol. Yearly IRs of hip/femur fractures were calculated for the general population and for those aged ≥50 years. Trends over time were evaluated using linear regression analysis for both crude and standardized IRs. Sex- and age-standardized IRs for the UK, Netherlands, and Spanish DBs varied from 9 to 11 per 10,000 person-years for the general population and from 22 to 26 for those ≥50 years old; the German DB showed slightly higher IRs (about 13 and 30, respectively), whereas the Danish DB yielded IRs twofold higher (19 and 52, respectively). IRs increased exponentially with age in both sexes. The ratio of females to males was ≥2 for patients aged ≥70-79 years in most DBs. Statistically significant trends over time were only shown for the UK DB (CPRD) (+0.7% per year, P < 0.01) and the Danish DB (-1.4% per year, P < 0.01). IRs of hip/femur fractures varied greatly across European countries. With the exception of Denmark, no decreasing trend was observed over the study period.
authors.affiliation: Pharmacology Unit, Department of Biomedical Sciences, School of Medicine and Health Sciences, University of Alcalá, Madrid, Spain, gema.requena@uah.es.
authors.forename: G
authors.initials: G
authors.lastname: Requena
authors.forename: V
authors.initials: V
authors.lastname: Abbing-Karahagopian
authors.forename: C
authors.initials: C
authors.lastname: Huerta
authors.forename: M L
authors.initials: ML
authors.lastname: De Bruin
authors.forename: Y
authors.initials: Y
authors.lastname: Alvarez
authors.forename: M
authors.initials: M
authors.lastname: Miret
authors.forename: U
authors.initials: U
authors.lastname: Hesse
authors.forename: H
authors.initials: H
authors.lastname: Gardarsdottir
authors.forename: P C
authors.initials: PC
authors.lastname: Souverein
authors.forename: J
authors.initials: J
authors.lastname: Slattery
authors.forename: C
authors.initials: C
authors.lastname: Schneider
authors.forename: M
authors.initials: M
authors.lastname: Rottenkolber
authors.forename: S
authors.initials: S
authors.lastname: Schmiedl
authors.forename: M
authors.initials: M
authors.lastname: Gil
authors.forename: M C H
authors.initials: MC
authors.lastname: De Groot
authors.forename: A
authors.initials: A
authors.lastname: Bate
authors.forename: A
authors.initials: A
authors.lastname: Ruigómez
authors.forename: L A
authors.initials: LA
authors.lastname: García Rodríguez
authors.forename: S
authors.initials: S
authors.lastname: Johansson
authors.forename: F
authors.initials: F
authors.lastname: de Vries
authors.forename: D
authors.initials: D
authors.lastname: Montero
authors.forename: R
authors.initials: R
authors.lastname: Schlienger
authors.forename: R
authors.initials: R
authors.lastname: Reynolds
authors.forename: O H
authors.initials: OH
authors.lastname: Klungel
authors.forename: F J
authors.initials: FJ
authors.lastname: de Abajo
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D016208:Databases, Factual; D003718:Denmark / Q000453:epidemiology; D057286:Electronic Health Records; D005260:Female; D005265:Femoral Neck Fractures / Q000453:epidemiology*; D005858:Germany / Q000453:epidemiology; D006620:Hip Fractures / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology; D006113:United Kingdom / Q000453:epidemiology