title: Genetic endowment of proinflammatory cytokine tumor necrosis factor-α (-) 308 G > A polymorphism to Parthenium hysterophorus-induced airborne contact dermatitis in an Indian cohort.
abstract: BACKGROUND
  Parthenium dermatitis is a common airborne allergic health problem that induces a cell-mediated hypersensitivity immune response involving activated T lymphocytes, which culminates in injury to the skin. The disease is manifested as itchy erythematous papules and plaques and primarily affects the exposed areas and flexures. This study aimed to identify the role of tumor necrosis factor (TNF)-α (-) 308 G>A polymorphism in the pathogenesis of parthenium dermatitis.
  
  
  METHODS
  A total of 120 subjects, including 60 patients exclusively diagnosed for parthenium dermatitis and 60 healthy individuals, were included in the study. The genotyping of the TNF-α (-) 308 G>A region was carried out by the amplification refractory mutational system.
  
  
  RESULTS
  In the present study, we demonstrated that polymorphism of the TNF-α (-) 308 position (A and/or G) was not statistically significant, and there was no difference in the distribution of any alleles of this locus in cases and controls.
  
  
  CONCLUSIONS
  The present study suggests that there is a lack of association of potent proinflammatory cytokine TNF-α (-) 308 G>A polymorphism in parthenium dermatitis in the Indian cohort. It interprets genetically endowed transcriptional capacity due to this particular single nucleotide polymorphism but does not support the prevalence of high serum levels of TNF-α in parthenium-induced skin allergic inflammation.
authors.affiliation: School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Khatri
authors.forename: Nasim
authors.initials: N
authors.lastname: Akhtar
authors.forename: Kasturi
authors.initials: K
authors.lastname: Mukhopadhyay
authors.forename: Kaushal K
authors.initials: KK
authors.lastname: Verma
authors.forename: Gomathy
authors.initials: G
authors.lastname: Sethuraman
authors.forename: Alpana
authors.initials: A
authors.lastname: Sharma
mesh_terms: D000328:Adult; D052179:Antigens, Plant / Q000276:immunology; D019659:Asteraceae / Q000276:immunology*; D016022:Case-Control Studies; D015331:Cohort Studies; D017449:Dermatitis, Allergic Contact / Q000235:genetics* / Q000276:immunology; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D010312:Parthenogenesis; D010328:Patch Tests; D010936:Plant Extracts / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D000097762:Parthenium hysterophorus
chemical_list: D052179:Antigens, Plant; C519376:Parthenium hysterophorus extract; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha