title: Leukocytosis, muscle damage and increased lymphocyte proliferative response after an adventure sprint race.
abstract: The effect of an adventure sprint race (ASR) on T-cell proliferation, leukocyte count and muscle damage was evaluated. Seven young male runners completed an ASR in the region of Serra do Espinhaço, Brazil. The race induced a strong leukocytosis (6.22±2.04×10(3) cells/mm3 before vs 14.81±3.53×10(3) cells/mm3 after the race), marked by a significant increase of neutrophils and monocytes (P<0.05), but not total lymphocytes, CD3+ CD4+ or CD3+ CD8+ cells. However, the T-cell proliferative response to mitogenic stimulation was increased (P=0.025) after the race, which contradicted our hypothesis that ASR, as a high-demand competition, would inhibit T-cell proliferation. A positive correlation (P=0.03, r=0.79) was observed between the proliferative response of lymphocytes after the race and the time to complete the race, suggesting that the proliferative response was dependent on exercise intensity. Muscle damage was evident after the race by increased serum levels of aspartate amino transferase (24.99±8.30 vs 50.61±15.76 U/L, P=0.003). The results suggest that humoral factors and substances released by damaged muscle may be responsible for lymphocyte activation, which may be involved in muscle recovery and repair.
authors.affiliation: Departamento de Fisioterapia, Faculdade de Ciências Biológicas e da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brasil.
authors.forename: R
authors.initials: R
authors.lastname: Tossige-Gomes
authors.affiliation: Departamento de Fisioterapia, Faculdade de Ciências Biológicas e da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brasil.
authors.forename: V O
authors.initials: VO
authors.lastname: Ottone
authors.affiliation: Departamento de Educação Física, Faculdade de Ciências Biológicas e da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brasil.
authors.forename: P N
authors.initials: PN
authors.lastname: Oliveira
authors.affiliation: Departamento de Educação Física, Faculdade de Ciências Biológicas e da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brasil.
authors.forename: D J S
authors.initials: DJ
authors.lastname: Viana
authors.affiliation: Departamento de Fisioterapia, Faculdade de Ciências Biológicas e da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brasil.
authors.forename: T L
authors.initials: TL
authors.lastname: Araújo
authors.affiliation: Departamento de Educação Física, Faculdade de Ciências Biológicas e da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brasil.
authors.forename: F J
authors.initials: FJ
authors.lastname: Gripp
authors.affiliation: Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brasil.
authors.forename: E
authors.initials: E
authors.lastname: Rocha-Vieira
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D049109:Cell Proliferation / Q000502:physiology*; D005434:Flow Cytometry; D006801:Humans; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D007964:Leukocytosis / Q000209:etiology / Q000276:immunology*; D008297:Male; D009000:Monocytes / Q000276:immunology; D018482:Muscle, Skeletal / Q000276:immunology / Q000293:injuries*; D009504:Neutrophils / Q000276:immunology; D010807:Physical Endurance / Q000276:immunology* / Q000502:physiology; D012420:Running / Q000293:injuries* / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology; D013997:Time Factors
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase