title: [Autosomal dominant polycystic kidney disease in hemodialysis patients in Southern Brazil].
abstract: BACKGROUND
  Autosomal dominant polycystic kidney disease is the most common hereditary renal disease in humans.
  
  
  OBJECTIVE
  To examine the prevalence, clinical and laboratory characteristics of patients with polycystic kidneys and relate disease manifestations by gender.
  
  
  METHODS
  This was an observational and retrospective study. All the medical records of patients with polycystic kidneys who initiated hemodialysis between 1995 and 2012, in four centers that treat patients of the coverage area of the 15th regional health Paraná (Brazil), were analyzed.
  
  
  RESULTS
  The study included 48 patients with polycystic kidneys, the primary cause of stage 5 CKD. Disease prevalence was one in 10,912 people. The average age of dialysis initiation was 50.7 years and the follow-up time on dialysis until transplantation (36.5 months) was lower among men. Hypertension was the most frequent diagnosis in 73% of patients, predominantly in women (51.4%). The liver cyst was the most frequent extrarenal manifestations in men (60.0%). The death occurred in 10.4% of patients using hemodialysis, and 60% of men. The class of antihypertensive drug used was that acts on the renin-angiotensin system with higher frequency of use among women (53.3%). The post-dialysis urea was significantly higher in men.
  
  
  CONCLUSIONS
  The prevalence of the disease is low among hemodialysis patients in southern Brazil. The differences observed between genders, with the exception of the post-dialysis urea, were not significant. The findings are different from those reported in North America and Europe.
authors.affiliation: Universidade Estadual de Maringa.
authors.forename: Everton Fernando
authors.initials: EF
authors.lastname: Alves
authors.affiliation: Universidade Federal do Parana.
authors.forename: Luiza Tamie
authors.initials: LT
authors.lastname: Tsuneto
authors.affiliation: Universidade de Sao Paulo (USP).
authors.forename: Sandra Marisa
authors.initials: SM
authors.lastname: Pelloso
authors.affiliation: Universidade Estadual de Maringa.
authors.forename: Paulo Roberto Aranha
authors.initials: PR
authors.lastname: Torres
authors.affiliation: Instituto do Rim de Maringa.
authors.forename: Guido Luis Gomes
authors.initials: GL
authors.lastname: Otto
authors.affiliation: Clinica do Rim de Maringa.
authors.forename: Adaelson Alves
authors.initials: AA
authors.lastname: Silva
authors.affiliation: Universidade Estadual de Londrina.
authors.forename: José Miguel Viscarra
authors.initials: JM
authors.lastname: Obregon
authors.affiliation: Faculdade Evangelica do Parana.
authors.forename: Letícia Nicoletti
authors.initials: LN
authors.lastname: Silva
authors.affiliation: Universidade de Sao Paulo (USP).
authors.forename: Maria Dalva de Barros
authors.initials: MD
authors.lastname: Carvalho
mesh_terms: D001938:Brazil / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D015995:Prevalence; D006435:Renal Dialysis; D012189:Retrospective Studies