title: Sporadic Creutzfeldt-Jakob disease (sCJD) with asymmetric findings.
abstract: We report a case of a patient with probable Creutzfeldt-Jakob disease (CJD) who had psychiatric manifestation in the form of withdrawn depressive behaviour at the onset, followed by rapidly progressive ataxia, parkinsonism, mutism and cognitive decline with generalised asynchronous multifocal myoclonic jerks. His EEG exhibited focal (lateralised) periodic triphasic sharp waves on the background of generalised delta slowing, which later on became more generalised. MRI of the brain showed hyperintensity in basal ganglia with cortical ribbon sign in bilateral frontal region. Clinical course showed progressive deterioration to an akinetic-abulic stage. He died 2 months after the onset of symptoms.
authors.affiliation: Department of Neurology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Khilari
authors.forename: Sunitha Vellathussery
authors.initials: SV
authors.lastname: Chakkalakkoombil
authors.forename: Vaibhav
authors.initials: V
authors.lastname: Wadwekar
authors.forename: Pradeep Pankajakshan
authors.initials: PP
authors.lastname: Nair
mesh_terms: D001259:Ataxia / Q000209:etiology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003863:Depression / Q000209:etiology; D003937:Diagnosis, Differential; D004569:Electroencephalography; D017809:Fatal Outcome; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D020734:Parkinsonian Disorders / Q000209:etiology