title: [Interventional hypertension therapy in diabetes mellitus. Effects on blood pressure and glucose metabolism?].
abstract: Hypertension is the most common chronic cardiovascular disease with increasing prevalence all over the world. Despite the availability of many effective antihypertensive drugs, blood pressure control to target values remains low. In the pathophysiology of therapy resistant hypertension, increased activity of the sympathetic nervous system with an imbalance between sympathetic and parasympathetic activity has been identified as a main contributor to the development and maintenance of hypertension. Catheter-based denervation of the renal sympathetic nerves has been described as reducing blood pressure and decreasing sympathetic activity in patients with resistant hypertension. Supplementary beneficial effects on common cardiovascular comorbidities, such as diabetes type 2, have been reported. The present review aims to give an overview about percutaneous renal denervation for treatment of hypertension and potential new therapeutic options to improve glycemic control.
authors.affiliation: Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Kirrberger Str., Geb. 40, 66421, Homburg/Saar, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Ewen
authors.forename: C
authors.initials: C
authors.lastname: Ukena
authors.forename: J
authors.initials: J
authors.lastname: Pöss
authors.forename: D
authors.initials: D
authors.lastname: Linz
authors.forename: M
authors.initials: M
authors.lastname: Böhm
authors.forename: F
authors.initials: F
authors.lastname: Mahfoud
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D048909:Diabetes Complications / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery*; D007668:Kidney / Q000294:innervation* / Q000601:surgery; D013562:Sympathectomy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose