title: A comparative study on the efficacy of Ibuprofen and celecoxib on the intensity of perineal pain following episiotomy: a randomized clinical trial.
abstract: BACKGROUND
  Pain is a worldwide problem that often originates from disease process, and diagnostic and treatment procedures such as surgical operations.
  
  
  OBJECTIVE
  This trial was performed to compare the effectiveness of two analgesics for the management of perineal pain caused by episiotomy.
  
  
  METHODS
  A total of 170 nulliparous women who gave birth vaginally with episiotomy between March 2009 and November 2010 were randomly assigned to receive either ibuprofen or celecoxib which were given orally every 6 or 12 hours, respectively. Pain levels were measured before the intervention, and at 1, 2, 4, 8 and 12 hours after providing the first dose on a 10-cm visual analogue scale.
  
  
  RESULTS
  The results showed that the two groups had no significant differences regarding demographic characteristics, maternal, neonatal, and post-delivery factors, and mean premedication pain severity. Means of pain severity were different between the two groups as patients in the celecoxib group had lower means than the other group at 1,2,4,8 and 12 hours (4.01 ± 1.8 vs. 4.46 ± 1.9, 3.17 ± 1.9 vs. 3.79 ± 1.7, 2.89 ± 1.3 vs. 2.96 ± 1.5, 2.19 ± 1.8 vs. 2.55 ± 1.4, and 1.98 ± 1.1 vs. 2.45 ± 1.2, respectively) after administration of analgesics.
  
  
  CONCLUSIONS
  Patients who received celecoxib had lower VAS in comparison with others. Although these differences were not significant, as celecoxib has longer half-life, fewer upper GI symptoms, and is better tolerated based on the previous studies, and this study is in favor of using it.
authors.affiliation: Department of Midwifery, Ilam University of Medical Sciences, Ilam, IR Iran.
authors.forename: Zainab
authors.initials: Z
authors.lastname: Suhrabi
authors.affiliation: Department of Midwifery, Ilam University of Medical Sciences, Ilam, IR Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Taghinejad
keywords: Celecoxib; Episiotomy; Ibuprofen; Neuralgia