title: Modeling analysis of the lymphocytopoiesis dynamics in chronically irradiated residents of Techa riverside villages.
abstract: A biologically motivated dynamical model of the lymphocytopoietic system in irradiated humans is applied here to analyze the data obtained under hematological examinations of residents of Techa riverside villages. Those people were exposed to chronic irradiation with varying dose rates, due to the radioactive contamination of the river basin by the Mayak Production Association. Modeling studies revealed the relationship between the dynamics of the lymphocytopoietic system in the examined individuals and the variation of dose rate over the considered period of time. It is found that the developed model is capable of reproducing the decreased level of blood lymphocyte concentration observed during the period of maximum radiation exposure, the recovery processes in the system observed during the period of decreasing dose rate, as well as the enhanced mitotic activity of bone marrow precursor cells in this hematopoietic lineage observed during the entire period under consideration. Mechanisms of these effects of chronic irradiation on the human lymphocytopoietic system are elucidated based on the applied model. The results obtained demonstrate the efficiency of the developed model in the analysis, investigation, and prediction of effects of chronic irradiation with varying dose rate on the human lymphocytopoietic system. In particular, the developed model can be used for predicting any radiation injury of this vital system in people exposed to chronic irradiation due to environmental radiological events, such as anthropogenic radiation accidents or radiological terroristic attacks.
authors.affiliation: Federal State Unitary Enterprise Research and Technical Center of Radiation-Chemical Safety and Hygiene, 40 Shchukinskaya st., 123182 , Moscow, Russian Federation.
authors.forename: Olga A
authors.initials: OA
authors.lastname: Smirnova
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Akleyev
authors.forename: Georgy P
authors.initials: GP
authors.lastname: Dimov
mesh_terms: D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006798:Housing; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000528:radiation effects*; D008954:Models, Biological; D045483:Rivers / Q000737:chemistry*; D012426:Russia; D013997:Time Factors; D014878:Water Pollution, Radioactive / Q000009:adverse effects*