title: Mesoporous silica-coated plasmonic nanostructures for surface-enhanced Raman scattering detection and photothermal therapy.
abstract: The design and fabrication of core-shell and yolk-shell nanostructures with surface plasmon resonance (SPR)-active center protected by permeable mesoporous channels can raise the new vitality into the catalysis and biological applications. Hybrid plasmonic-mesoporous silica nanocarriers consisting of Ag and Au-Ag alloy nanoparticles are fabricated through spatially confined galvanic replacement approach. The plasmonic absorption peaks can be finely controlled to the near-infrared (NIR) region (500-790 nm) that is beneficial for tissue transmittance. The mesoporous silica shell facilitates also protection of Au-Ag cores and affords the channels between the exterior and interior capsule environments, thereby endowing the multiple applications. In the present work, it is successfully demonstrated that mesoporous silica-coated Au-Ag alloy core-shell and yolk-shell nanocarriers can serve as good substrates for surface-enhanced Raman scattering (SERS) detection. The SERS signal intensities of nanocarriers are highly dependent on the SPR peaks and the contents of gold. Simultaneously, the synthesized Au-Ag@mSiO2 nanocarriers with SPR peak at ≈790 nm can be applied in NIR-sensitive SERS detection and photothermal therapy.
authors.affiliation: Shanghai Key Laboratory of Molecular Catalysis and Laboratory of Advanced Materials, Department of Chemistry, Fudan University, Shanghai, 200433, P. R. China; State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, P. R. China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Yang
authors.forename: Dengke
authors.initials: D
authors.lastname: Shen
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Jianwei
authors.initials: J
authors.lastname: Fan
authors.forename: Ahmed Mohamed
authors.initials: AM
authors.lastname: El-Toni
authors.forename: Wei-xian
authors.initials: WX
authors.lastname: Zhang
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Zhao
mesh_terms: D006046:Gold / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D010789:Phototherapy / Q000379:methods*; D012822:Silicon Dioxide / Q000737:chemistry*; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; D012834:Silver; D006046:Gold; D012822:Silicon Dioxide
keywords: core-shell; mesoporous materials; photothermal therapy; plasmonic nanostructures; surface-enhanced Raman scattering; yolk-shell