title: Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-ovarian axis in adult female rats.
abstract: Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely present in the environment and some products with phthalate plasticizer. It has become a serious problem in recent years. The effect of DEHP on female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on hypothalamus-pituitary-ovarian axis in adult female rats. Compared with control rats, the DEHP-treated rats showed: (1) lower body weight; (2) lower organ coefficient of ovary; (3) higher GnRH level in the hypothalamus; (4) higher mRNA and protein levels of GnRHR in the pituitary; and (5) lower serum sex hormone levels. Our data reveal that DEHP exposure may lead to the disruption of estrogen biosynthesis pathways in female rats and imbalance of hypothalamus-pituitary-ovarian axis. DEHP may impose negative influence on the development and function of the reproductive system in female rats.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
authors.forename: Te
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
authors.forename: Guangyan
authors.initials: G
authors.lastname: Yu
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Guo
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
authors.forename: Liting
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
authors.forename: Dongchun
authors.initials: D
authors.lastname: Zheng
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Qu
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Emergency, China Japan Union Hospital, Jilin University, Changchun, China.
authors.forename: Shuyue
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China. Electronic address: jlyelin@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Ye
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004051:Diethylhexyl Phthalate / Q000633:toxicity*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000378:metabolism; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D010968:Plasticizers / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000187:drug effects
chemical_list: D012739:Gonadal Steroid Hormones; D010968:Plasticizers; D007987:Gonadotropin-Releasing Hormone; D004051:Diethylhexyl Phthalate
keywords: Di-(2-ethylhexyl) phthalate; Endocrine disruptors; HPOA; Reproductive toxicity; Sex hormone