title: Hyperbilirubinemia complicating plasma-free hemoglobin and antifactor Xa level monitoring on venovenous extracorporeal membrane oxygenation.
abstract: Optical spectrophotometric methods are used to detect both plasma-free hemoglobin and antifactor Xa level, so hyperbilirubinemia can interfere with the measurement of both the monitoring laboratory tests for extracorporeal membrane oxygenation (ECMO) due to similar absorbance wavelengths. We present a seven-year-old child with acute respiratory failure on venovenous ECMO who developed an acute increase in plasma-free hemoglobin and undetectable antifactor Xa level due to acute hyperbilirubinemia from hepatic dysfunction related to antifungal therapy.
authors.affiliation: Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
authors.forename: Patrick I
authors.initials: PI
authors.lastname: McConnell
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Preston
authors.forename: Kathleen K
authors.initials: KK
authors.lastname: Nicol
mesh_terms: D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002648:Child; D054714:Echinocandins / Q000009:adverse effects / Q000627:therapeutic use; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects / Q000379:methods; D065427:Factor Xa Inhibitors; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D006932:Hyperbilirubinemia; D055666:Lipopeptides / Q000009:adverse effects / Q000627:therapeutic use; D017563:Lung Diseases, Interstitial / Q000628:therapy*; D008297:Male; D000077551:Micafungin; D013053:Spectrophotometry
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D065427:Factor Xa Inhibitors; D006454:Hemoglobins; D055666:Lipopeptides; D000077551:Micafungin
keywords: antifactor Xa level; extracorporeal membrane oxygenation; hepatic dysfunction; hyperbilirubinemia; plasma-free hemoglobin; venovenous