title: Oral administration of soy peptides suppresses cognitive decline by induction of neurotrophic factors in SAMP8 mice.
abstract: SAMP8 mice have a shorter lifespan and show the dysfunction of the central nervous system. We here investigated whether soy peptides (SP) composed mainly of di- and tripeptides has the potential to prevent age-dependent cognitive impairment. SAMP8 and normal aging mice, SAMR1, were fed a diet supplemented with SP or a control diet for 26 weeks to investigate the preventive effects on the progression of cognitive decline using the Morris water maze. The SP-fed groups in SAMP8 and SAMR1 prevented the decline of cognitive ability compared to their controls. Increased expression of neurotrophic factors such as BDNF and NT-3 at mRNA and protein levels were observed in the brain of SP-fed mice, especially SAMP8. Further, the phosphorylated CREB protein level of SAMP8 was markedly up-regulated by SP feeding. These suggest that SPs have the potential for prevention of cognitive impairment via neurotrophic effects.
authors.affiliation: Department of Bioscience and Biotechnology, Shinshu University , 8304 Minamiminowa, Ina, Nagano 399-4598, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Katayama
authors.forename: Rie
authors.initials: R
authors.lastname: Imai
authors.forename: Haruka
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Soichiro
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000284:Administration, Oral; D000375:Aging / Q000187:drug effects* / Q000378:metabolism / Q000523:psychology; D000818:Animals; D003071:Cognition / Q000187:drug effects*; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000235:genetics* / Q000378:metabolism; D010455:Peptides / Q000008:administration & dosage*; D010766:Phosphorylation / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage*; D013025:Glycine max / Q000737:chemistry*; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D009414:Nerve Growth Factors; D010455:Peptides; D010936:Plant Extracts