title: Relation of the rs6923761 gene variant in glucagon-like peptide 1 receptor with weight, cardiovascular risk factor, and serum adipokine levels in obese female subjects.
abstract: BACKGROUND
  Studies of the glucagon-like peptide 1 (GLP-1) receptor have been directed at identifying polymorphisms in the GLP-1 receptor gene that may be a contributing factor in the pathogenesis of diabetes mellitus and cardiovascular risk factors. Nevertheless, the role of GLP-1 variants on body weight, cardiovascular risk factors, and adipokines remains unclear in obese patients.
  
  
  OBJECTIVE
  Our aim was to analyze the effects of rs6923761 GLP-1 receptor polymorphism on body weight, cardiovascular risk factors, and serum adipokine levels in nondiabetic obese females.
  
  
  METHODS
  A sample of 645 obese nondiabetic Caucasian females was enrolled in a prospective way. Basal fasting glucose, c-reactive protein (CRP), insulin, insulin resistance (homeostasis model assessment (HOMA)), total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides concentration, and adipokines were measured. Weights, body mass index (BMI), waist circumference, fat mass by bioimpedance, and blood pressure measures were measured.
  
  
  RESULTS
  Three hundred and twenty-seven participants (50.7%) had the genotype GG and 318 (49.3%) study subjects had the next genotypes; GA (270 study subjects, 41.9%) or AA (48 study subjects, 7.4%) (second group). In wild group (GG genotype), BMI (1.8 ± 2.3 kg/m(2) ; P < 0.05), weight (3.1 ± 1.3 kg; P < 0.05), fat mass (2.4 ± 1.1 kg; P < 0.05), waist circumference (2.7 ± 1.9 cm; P < 0.05), triglyceride levels (10.4 ± 5.3 mg/dl; P < 0.05), interleukin 6 (IL-6) (1.5 ± 0.9 ng/dl; P < 0.05), resistin (1.1 ± 0.3 ng/dl; P < 0.05), and leptin (30.1 ± 10.3 ng/dl; P < 0.05) levels were higher than mutant group (GA + AA).
  
  
  CONCLUSIONS
  Data from our study revealed an association with decreased metabolic and cardiovascular markers in obese females. BMI weight, fat mass, waist circumference, triglycerides, leptin, resistin, and IL-6 serum levels were lower in subjects with A allele than non-A allele subjects.
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.
authors.forename: Daniel Antonio
authors.initials: DA
authors.lastname: de Luis
authors.forename: Rocío
authors.initials: R
authors.lastname: Aller
authors.forename: B
authors.initials: B
authors.lastname: de la Fuente
authors.forename: D
authors.initials: D
authors.lastname: Primo
authors.forename: Rosa
authors.initials: R
authors.lastname: Conde
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.forename: Manuel Gonzalez
authors.initials: MG
authors.lastname: Sagrado
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000235:genetics*; D005260:Female; D005838:Genotype; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies; D018027:Receptors, Glucagon / Q000235:genetics*; D052243:Resistin / Q000097:blood; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D044465:White People
chemical_list: D054392:Adipokines; C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D015850:Interleukin-6; D020738:Leptin; D018027:Receptors, Glucagon; D052243:Resistin; D014280:Triglycerides
keywords: adipokines; cardiovascular risk factors; glucagon-like peptide 1 receptor; rs6923761; weight