title: Mesoporous silica nanoparticles/hydroxyapatite composite coated implants to locally inhibit osteoclastic activity.
abstract: In an attempt to improve implant-bone integration and accelerate bone fracture healing from resisting osteoclastic resorption point of view, we have employed a novel procedure to develop a mesoporous silica nanoparticles/hydroxyapatite (MSNs/HA) composite coating onto stainless Kirschner wire substrate. Characterizations of the surface microstructures indicated enlarged specific surface area compared to HA-coated wires as control, thus the MSNs/HA composite coated implants are endowed with abilities to locally deliver biomedical substances and enhance fracture healing. Herein, zoledronic acid (ZOL) as a model drug, different doses of which were immobilized in the mesoporous coating toward decreasing osteoclastic resorption activity. The loading capacities of ZOL increased almost eight-folds to that of pure HA coating, and the introduction of MSNs obviously retarded ZOL release to achieve a more sustained release profile. After certain periods of osteoclast like cells co-culturing with ZOL contained wires, tartrat-resistant acid phosphatases (TRAP) staining of polynucleated cells and a pit formation assay were performed to investigate the ZOL dose-dependent anti-resorption activity. The promoted local effect on osteoclasts will be of clinical benefit to support implant integration and bone repair.
authors.affiliation: School of Materials Science and Engineering, University of Shanghai for Science and Technology , Shanghai, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Yufang
authors.initials: Y
authors.lastname: Zhu
authors.forename: Bin
authors.initials: B
authors.lastname: Ni
authors.forename: Ning
authors.initials: N
authors.lastname: Xie
authors.forename: Xuhua
authors.initials: X
authors.lastname: Lu
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
authors.forename: Xiang
authors.initials: X
authors.lastname: Guo
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy*; D001864:Bone Wires; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004164:Diphosphonates / Q000737:chemistry / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D053758:Nanoparticles / Q000737:chemistry*; D010010:Osteoclasts / Q000187:drug effects / Q000502:physiology*; D016062:Porosity; D019736:Prostheses and Implants; D012822:Silicon Dioxide / Q000737:chemistry*; D000077211:Zoledronic Acid
chemical_list: D020099:Coated Materials, Biocompatible; D004164:Diphosphonates; D004337:Drug Carriers; D007093:Imidazoles; D000077211:Zoledronic Acid; D012822:Silicon Dioxide; D017886:Durapatite