title: Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up.
abstract: BACKGROUND
  Recently, five branched-chain and aromatic amino acids were shown to be associated with the risk of developing type 2 diabetes (T2D).
  
  
  OBJECTIVE
  We set out to examine whether amino acids are also associated with the development of hypertriglyceridemia.
  
  
  METHODS
  We determined the serum amino acids concentrations of 1,125 individuals of the KORA S4 baseline study, for which follow-up data were available also at the KORA F4 7 years later. After exclusion for hypertriglyceridemia (defined as having a fasting triglyceride level above 1.70 mmol/L) and diabetes at baseline, 755 subjects remained for analyses.
  
  
  RESULTS
  Increased levels of leucine, arginine, valine, proline, phenylalanine, isoleucine and lysine were significantly associated with an increased risk of hypertriglyceridemia. These associations remained significant when restricting to those individuals who did not develop T2D in the 7-year follow-up. The increase per standard deviation of amino acid level was between 26 and 40 %.
  
  
  CONCLUSIONS
  Seven amino acids were associated with an increased risk of developing hypertriglyceridemia after 7 years. Further studies are necessary to elucidate the complex role of these amino acids in the pathogenesis of metabolic disorders.
authors.affiliation: Department of Physiology and Biophysics, Weill Cornell Medical College, Qatar, PO Box 24144, Doha, Qatar.
authors.forename: D O
authors.initials: DO
authors.lastname: Mook-Kanamori
authors.forename: W
authors.initials: W
authors.lastname: Römisch-Margl
authors.forename: G
authors.initials: G
authors.lastname: Kastenmüller
authors.forename: C
authors.initials: C
authors.lastname: Prehn
authors.forename: A K
authors.initials: AK
authors.lastname: Petersen
authors.forename: T
authors.initials: T
authors.lastname: Illig
authors.forename: C
authors.initials: C
authors.lastname: Gieger
authors.forename: R
authors.initials: R
authors.lastname: Wang-Sattler
authors.forename: C
authors.initials: C
authors.lastname: Meisinger
authors.forename: A
authors.initials: A
authors.lastname: Peters
authors.forename: J
authors.initials: J
authors.lastname: Adamski
authors.forename: K
authors.initials: K
authors.lastname: Suhre
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000097:blood*; D001120:Arginine / Q000097:blood; D001622:Betaine / Q000097:blood; D015992:Body Mass Index; D005215:Fasting; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D007532:Isoleucine / Q000097:blood; D007930:Leucine / Q000097:blood; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010649:Phenylalanine / Q000097:blood; D011392:Proline / Q000097:blood; D012372:ROC Curve; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014633:Valine / Q000097:blood
chemical_list: D000596:Amino Acids; D014280:Triglycerides; D007532:Isoleucine; D001622:Betaine; D010649:Phenylalanine; D001120:Arginine; D011392:Proline; D007930:Leucine; D014633:Valine