title: [Collagenase injection in Dupuytren's disease, evaluation of the ultrasound assisted technique].
abstract: Since October 2011, the enzymatic lysis of Dupuytren's cord was introduced in Switzerland (Xiapex(®), Auxilium Pharmaceuticals, Pfizer). Here we present our first university experience and underline the major role of ultrasound during the injection. Between December 2011 and February 2013, 52 injections were performed to eliminate 43 Dupuytren's cords in 33 patients. The mean age of the patients was 64.4 ± 8.5 years. Complications were documented for each patient. Before, directly after and after a minimum of 6 months post-injection, the contracture of the treated joint was measured with use of a goniometer. The DASH score was evaluated after a minimum of 6 months and the patients were asked to subjectively evaluate the outcome of the treatment (very good, good, mild, poor) and whether they would reiterate it if necessary. Four skin defects, one lymphangitis, and one CRPS were responsible for a complication rate of 18%. There was no infection and no tendon rupture in the series. The mean MCP joint contracture was respectively 36.8 ± 27.4°, 3.5 ± 7.8° (gain of mobility compared to the preoperative situation 33.3°, P<0.001), and 8.4 ± 13.9° (gain 28.4°, P<0.001) respectively before, just after and at the long-term clinical control. The mean PIP joint contracture was respectively 36.5 ± 29.1°, 5.9 ± 6.7° (gain 30.6°, P<0.001), and 15.1 ± 13.8° (gain 21.4°, P<0.001) respectively before injection, just after and at the long-term clinical control. The DASH score decreased from 24 ± 14 to 7 ± 9 (P<0.001). Eighty-one per cent of the patients were satisfied or very satisfied of the treatment. All but two would reiterate the treatment if necessary. Ultrasound is able to target the injection of collagenase in order to reduce complications. The short-term results of this non-invasive therapy are very promising however comparison with conventional procedures is difficult as the long-term results are lacking.
authors.affiliation: Service de chirurgie plastique, chirurgie de la main et des nerfs périphériques, Inselspital Berne, université de Berne, Freiburgstrasse, 3010 Bern, Suisse. Electronic address: franckleclere@yahoo.fr.
authors.forename: F-M
authors.initials: FM
authors.lastname: Leclère
authors.affiliation: Service de chirurgie plastique, chirurgie de la main et des nerfs périphériques, Inselspital Berne, université de Berne, Freiburgstrasse, 3010 Bern, Suisse.
authors.forename: L
authors.initials: L
authors.lastname: Mathys
authors.affiliation: Service de chirurgie plastique, chirurgie de la main et des nerfs périphériques, Inselspital Berne, université de Berne, Freiburgstrasse, 3010 Bern, Suisse.
authors.forename: E
authors.initials: E
authors.lastname: Vögelin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017364:Collagenases / Q000627:therapeutic use*; D004387:Dupuytren Contracture / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D016059:Range of Motion, Articular; D018084:Ultrasonography, Interventional
chemical_list: D017364:Collagenases; C570746:xiapex
keywords: Collagenase; Collagénase; Cordes; Cords; Dupuytren; Ultrasound; Xiapex(®); Échographie