title: Pilot study of preoperative immunonutrition with antioxidants in living donor liver transplantation donors.
abstract: BACKGROUND
  Previous studies have demonstrated that oxidative stress by mediating the excessive production of reactive oxygen species is involved in tissue damage and organ failure during and after surgery. The impact of the preoperative immunonutrition including antioxidants on the postoperative course of patients undergoing hepatic surgery was investigated in this pilot study.
  
  
  METHODS
  Twenty-three living donor liver transplantation (LDLT) donors were randomly assigned to either an experimental (AO) group, received a commercial supplement enriched with antioxidant nutrients for each of the 5 days immediately prior to surgery while maintaining normal food intake, or a control (CT) group, administered no supplement. Antioxidative capacity was measured by spectrophotometry of patient serum using a free-radical analytical system.
  
  
  RESULTS
  The antioxidative capacity of 90.9% patients in the AO group increased after immunonutrition. Compared to the CT group, the AO group was found to have higher antioxidant capacity and transferrin levels; lower WBC, lymphocyte, and neutrophil counts; and briefer duration of postoperative fever during the postsurgical period. No significant differences were found between the 2 groups regarding the nutritional parameters; liver functioning parameters; immunological parameters; intraoperative factors; postoperative outcomes.
  
  
  CONCLUSIONS
  Preoperative immunonutrition including antioxidants might play a beneficial role in improving postsurgical immunological response but the modest biological advantage was not associated with any significant clinical outcome.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Nagata
authors.forename: Ken
authors.initials: K
authors.lastname: Shirabe
authors.forename: Keishi
authors.initials: K
authors.lastname: Sugimachi
authors.forename: Toru
authors.initials: T
authors.lastname: Ikegami
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Yoshizumi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Uchiyama
authors.forename: Yo-Ichi
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saeki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kawanaka
authors.forename: Koshi
authors.initials: K
authors.lastname: Mimori
authors.forename: Masayuki
authors.initials: M
authors.lastname: Watanabe
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Gion
authors.forename: Yuji
authors.initials: Y
authors.lastname: Soejima
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ikeda
authors.forename: Shunichi
authors.initials: S
authors.lastname: Tsujitani
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D019587:Dietary Supplements; D005260:Female; D005609:Free Radicals / Q000009:adverse effects / Q000097:blood; D006498:Hepatectomy; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D044623:Nutrition Therapy / Q000379:methods; D018384:Oxidative Stress / Q000502:physiology; D010865:Pilot Projects; D011300:Preoperative Care; D020858:Tissue and Organ Harvesting; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D005609:Free Radicals