title: Neurotoxic impact of organophosphate pesticide phosphomedon on the albino rat.
abstract: Organophosphate pesticide phosphomedon was exposed to albino rat at a concentration of 35 ppm in the time interval of 30, 45 and 60 days. During the exposure period neurobehavioral symptoms such as reduce food intake, weight loss, increase water intake, low defecation frequency, increase locomotion frequency at high dose were observed. Locomotion frequency were less initially but higher in increasing dose concentration. The result was also different in both the sexes. A decrease social interaction and increase force swimming with increasing dose concentration, which was not significant as comparison to control. A significant histopathological changes observed in three dose concentrations. In 30 days phosphomedon exposure the nuclear shape changes to oval, pear shaped along with fibrosis, lipidosis, 45 days exposure showed the increase number of nucleus, Chromatolysis, inflammatory nucleus, pyknosis. In 60 days test group histopathological picture showed the swelling of cell body, lipidosis, demylination, necrosis in brain cells. Over all result indicated that due to impact of O. P pesticide phosphomedon a severe histopathological changes occurs which was distinctly observed in neurobehavioural changes.
authors.forename: Ranjit
authors.initials: R
authors.lastname: Hazarika
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects*; D003672:Defecation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008124:Locomotion; D008297:Male; D009474:Neurons / Q000187:drug effects*; D010707:Phosphamidon / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D012919:Social Behavior; D013550:Swimming
chemical_list: D007306:Insecticides; D010707:Phosphamidon