title: Does post-infectious olfactory loss affect mood more severely than chronic sinusitis with olfactory loss?
abstract: OBJECTIVE
  Olfactory deficits that develop after viral upper respiratory infection (URI) may have different effects on patient depression index compared to chronic sinusitis with olfactory loss. However, there have been no controlled trials to evaluate the different effects of chronic sinusitis and URI on depression index.
  
  
  METHODS
  Prospective study of 25 subjects in two groups.
  
  
  METHODS
  This study enrolled 25 participants who were diagnosed with post-URI olfactory loss as the study group and 25 patients with chronic sinusitis and olfactory loss as a control group. Control group participants were matched for age, sex, and degree of olfactory loss (threshold, discrimination, and identification [TDI]). We compared the Beck Depression Inventory (BDI) scores of each group and analyzed the correlation between TDI and BDI.
  
  
  RESULTS
  The mean BDI score of the post-URI group was significantly higher than that of the control group (14.52 ± 6.59 vs. 9.32 ± 5.23; P=.002). Age, sex, and TDI score did not affect BDI score in the post-URI olfactory loss group. However, BDI score in the sinusitis group was inversely correlated with TDI score (R=-0.423; P=.035), and the BDI score of female subjects (11.00 ± 5.13) was significantly higher than that of male subjects (5.00 ± 2.16; P = .047).
  
  
  CONCLUSIONS
  Post-URI olfactory loss affected patient mood more severely than chronic sinusitis with a similar degree of olfactory loss. This influence was not affected by sex, age, or TDI score in the post-URI olfactory loss group.
  
  
  METHODS
  3b.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Korea.
authors.forename: Yong G
authors.initials: YG
authors.lastname: Jung
authors.forename: Jun-Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Gi C
authors.initials: GC
authors.lastname: Park
mesh_terms: D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D002908:Chronic Disease; D003866:Depressive Disorder / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000209:etiology / Q000503:physiopathology; D000857:Olfaction Disorders / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology*; D055696:Olfactory Perception / Q000502:physiology; D011379:Prognosis; D011446:Prospective Studies; D011581:Psychological Tests; D012016:Reference Values; D012141:Respiratory Tract Infections / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors; D012852:Sinusitis / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D055815:Young Adult
keywords: Olfaction; age; anosmia; chronic sinusitis; depression; hyposmia; sex; upper respiratory infection