title: New anti-complement drugs: not so far away.
abstract: In this issue of Blood, Risitano et al demonstrate that small-molecule inhibitors of C3 cleavage prevent complement activation on erythrocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH); the authors demonstrate that these agents reach therapeutic concentrations after subcutaneous injection in nonhuman primates.
authors.affiliation: UNIVERSITY OF COLORADO DENVER.
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Thurman
mesh_terms: D000818:Animals; D003167:Complement Activation / Q000187:drug effects*; D003176:Complement C3 / Q000037:antagonists & inhibitors*; D006457:Hemoglobinuria, Paroxysmal / Q000188:drug therapy*; D006801:Humans; D010456:Peptides, Cyclic / Q000627:therapeutic use*
chemical_list: D003176:Complement C3; D010456:Peptides, Cyclic; C111828:compstatin