title: Assessment of intrarenal oxygenation in renal donor with blood oxygenation level-dependent magnetic resonance imaging.
abstract: OBJECTIVE
  To examine change of the apparent relaxation rate R2* values in living kidney donors after uninephrectomy using blood oxygenation level-dependent magnetic resonance imaging.
  
  
  METHODS
  Between July 2011 and January 2012, 45 kidney donors were enrolled into this study. Blood oxygenation level-dependent magnetic resonance imaging scanning was performed before surgery, 3 and 7 days postoperatively. Participants were followed up for 1 year.
  
  
  RESULTS
  The R2* values in medulla (mR2*) were significantly greater than that of cortex (cR2*), both in resected kidney and remaining one. cR2* values of the remaining kidney was 17.52 ± 1.36 s(-1) and then decrease significantly by 8.97% to 15.95 ± 1.14 s(-1) at 3 days (P <.001) and by 7.82% to 16.15 ± of 1.05 s(-1) at 7 days. No significant modification occurred in mR2* after surgery. Multivariate regression analysis showed that the decrease in cR2* values of the remaining kidney was positively associated with sex (r = 0.418), body surface area (r = 0.307), and preoperative cR2* values (r = 0.659). Comparing with glomerular filtration rate at 7 days, a further increment in the glomerular filtration rate was noted at 1 year in patients with cR2* values decrease of ≥ 10% at 1 week (62.63 ± 11.69 vs 56.97 ± 7.51 mL/min/1.73 m(2), P = .02) but not in the other patients (66.43 ± 10.89 vs 62.78 ± 13.74, P = .064).
  
  
  CONCLUSIONS
  Kidney donation will induce early, profound oxygenation modification within the renal cortex of the remaining kidney. Donors with cR2* value decrease of ≥ 10% at 1 week have a more favorable renal function compensation at 1 year.
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Turun
authors.initials: T
authors.lastname: Song
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
authors.affiliation: Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Zixing
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Fu
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Shaofeng
authors.initials: S
authors.lastname: He
authors.affiliation: Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Song
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: liangrenliu@126.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
mesh_terms: D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D019520:Living Donors; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D011446:Prospective Studies
chemical_list: D010100:Oxygen