title: Sonication-assisted drug encapsulation in layer-by-layer self-assembled gelatin-poly (styrenesulfonate) polyelectrolyte nanocapsules: process optimization.
abstract: We report the development of Layer-by-Layer (LbL) polyelectrolyte self-assembled nanocrystalline drug-delivery platform using two experimental factors, namely the number of coatings and temperature during deposition with three varying levels. The optimized formulation (Fopt) was assessed for zeta potential and particle size using Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM). Charge reversal along with an increase in particle size confirmed coating of polyelectrolyte on drug nanocrystals. The FT-IR study revealed no signs of incompatibility or change in formulation property during preformulation and stability study. This fact was further supported by DSC results.
authors.affiliation: a Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka, Shirpur, Maharashtra , India.
authors.forename: Abhijeet P
authors.initials: AP
authors.lastname: Pandey
authors.affiliation: a Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka, Shirpur, Maharashtra , India.
authors.forename: Saurabh S
authors.initials: SS
authors.lastname: Singh
authors.affiliation: a Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka, Shirpur, Maharashtra , India.
authors.forename: Ganesh B
authors.initials: GB
authors.lastname: Patil
authors.affiliation: a Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka, Shirpur, Maharashtra , India.
authors.forename: Pravin O
authors.initials: PO
authors.lastname: Patil
authors.affiliation: a Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka, Shirpur, Maharashtra , India.
authors.forename: Chetan J
authors.initials: CJ
authors.lastname: Bhavsar
authors.affiliation: a Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka, Shirpur, Maharashtra , India.
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Deshmukh
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000138:chemical synthesis*; D004339:Drug Compounding / Q000379:methods; D065546:Drug Liberation; D004355:Drug Stability; D004573:Electrolytes; D005780:Gelatin / Q000737:chemistry*; D007700:Kinetics; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D053758:Nanoparticles; D010316:Particle Size; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry*; D013010:Sonication; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D013696:Temperature
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D004573:Electrolytes; D053769:Nanocapsules; D011137:Polystyrenes; D010894:Piroxicam; C003321:polystyrene sulfonic acid; D005780:Gelatin; C059451:lornoxicam
keywords: Design of experiments; Lornoxicam; nanocrystals; probe sonication