title: A randomized clinical trial comparing the efficacy and safety of ramosetron versus ondansetron in patients undergoing abdominal surgery under general anesthesia.
abstract: BACKGROUND
  Post-operative nausea and vomiting is one of the most common and distressing complications after anesthesia and surgery. It may lead to serious post-operative complications. Ramosetron is a newer 5-HT3 receptor antagonist and has more potent and longer duration of antiemetic effects compared to first generation 5HT3 receptor antagonists. The purpose of this study was to compare the efficacy of Ramosetron for the prevention of post-operative nausea and vomiting with that of Ondansetron in patients undergoing abdominal surgeries under general anesthesia.
  
  
  METHODS
  In this randomized, double-blind study, 60 patients, 18-60 years of both genders falling under ASA I-II category scheduled for abdominal surgery were included. Group I received I.V ramosetron 0.3 mg while group II received I.V Ondansetron 4 mg at the time of extubation. The standard general anesthetic technique was used throughout. Postoperatively the incidences of nausea, vomiting, and safety assessments were performed at 1, 2, 6, and 24 h during the first 24 h after surgery.
  
  
  RESULTS
  There were no differences between groups with respect to patient demographics. The percentage of patients who had complete response (no PONV, and no need for another rescue antiemetic) from 0 to 24 h after anesthesia was 56% with ramosetron and 33% with ondansetron. The corresponding rates at 1, 2, 6, and 24 h after anesthesia were 76% and 63%, 76% and 50%, 100 and 83%, 100 and 93%, respectively. Safety profiles of the two drugs were comparable, as no clinically serious adverse effects caused by study drugs were observed in either of the groups.
  
  
  CONCLUSIONS
  Our study concludes that prophylactic therapy with ramosetron is highly efficacious than ondansetron in preventing PONV in patients undergoing abdominal surgery under general anesthesia.
authors.affiliation: Department of Anesthesia, Mahadevappa Rampure Medical College, Gulbarga, Karnataka, India.
authors.forename: Sriramamurthy
authors.initials: S
authors.lastname: Kaja
authors.affiliation: Department of Anesthesia, Mahadevappa Rampure Medical College, Gulbarga, Karnataka, India.
authors.forename: Ravindra S
authors.initials: RS
authors.lastname: Giri
authors.affiliation: Department of Anesthesia, Mahadevappa Rampure Medical College, Gulbarga, Karnataka, India.
authors.forename: Deepak V
authors.initials: DV
authors.lastname: Tugave
authors.affiliation: Department of Anesthesia, Mahadevappa Rampure Medical College, Gulbarga, Karnataka, India.
authors.forename: Mukarram
authors.initials: M
authors.lastname: Iqbal
keywords: General anesthesia; ondansetron; post-operative vomiting; postoperative nausea; ramosetron