title: Iron-catalyzed 1,2-addition of perfluoroalkyl iodides to alkynes and alkenes.
abstract: Iron catalysis has been developed for the intermolecular 1,2-addition of perfluoroalkyl iodides to alkynes and alkenes. The catalysis has a wide substrate scope and high functional-group tolerance. A variety of perfluoroalkyl iodides including CF3 I can be employed. The resulting perfluoroalkylated alkyl and alkenyl iodides can be further functionalized by cross-coupling reactions. This methodology provides a straightforward and streamlined access to perfluoroalkylated organic molecules.
authors.affiliation: Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISCI-LSCI, BCH 3305, 1015 Lausanne (Switzerland) http://lsci.epfl.ch.
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Chi Wai
authors.initials: CW
authors.lastname: Cheung
authors.forename: Xile
authors.initials: X
authors.lastname: Hu
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007454:Iodides / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000480:Alkynes; D007454:Iodides; D007501:Iron
keywords: alkyne; cross-coupling; fluorine; iron; synthetic methods