title: Neurotrophin signalling and transcription programmes interactions in the development of somatosensory neurons.
abstract: Somatosensory neurons of the dorsal root ganglia are generated from multipotent neural crest cells by a process of progressive specification and differentiation. Intrinsic transcription programmes active in somatosensory neuron progenitors and early post-mitotic neurons drive the cell-type expression of neurotrophin receptors. In turn, signalling by members of the neurotrophin family controls expression of transcription factors that regulate neuronal sub-type specification. This chapter explores the mechanisms by which this crosstalk between neurotrophin signalling and transcription programmes generates the diverse functional sub-types of somatosensory neurons found in the mature animal.
authors.affiliation: INSERM U1051, Institut des Neurosciences de Montpellier (INM), 80, rue Augustin Fliche, 34091, Montpellier, France.
authors.forename: F
authors.initials: F
authors.lastname: Marmigère
authors.forename: P
authors.initials: P
authors.lastname: Carroll
mesh_terms: D000818:Animals; D005727:Ganglia, Spinal / Q000166:cytology* / Q000502:physiology; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D020917:Receptor, trkA / Q000502:physiology; D011984:Sensory Receptor Cells / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D009414:Nerve Growth Factors; D014157:Transcription Factors; D020917:Receptor, trkA