title: Automated segmentation of the cerebellar lobules using boundary specific classification and evolution.
abstract: The cerebellum is instrumental in coordinating many vital functions ranging from speech and balance to eye movement. The effect of cerebellar pathology on these functions is frequently examined using volumetric studies that depend on consistent and accurate delineation, however, no existing automated methods adequately delineate the cerebellar lobules. In this work, we describe a method we call the Automatic Classification of Cerebellar Lobules Algorithm using Implicit Multi-boundary evolution (ACCLAIM). A multiple object geometric deformable model (MGDM) enables each boundary surface of each individual lobule to be evolved under different level set speeds. An important innovation described in this work is that the speed for each lobule boundary is derived from a classifier trained specifically to identify that boundary. We compared our method to segmentations obtained using the atlas-based and multi-atlas fusion techniques, and demonstrate ACCLAIM's superior performance.
authors.forename: John A
authors.initials: JA
authors.lastname: Bogovic
authors.forename: Pierre-Louis
authors.initials: PL
authors.lastname: Bazin
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Ying
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Prince
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D002531:Cerebellum / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique