title: [FXR and its influence on hepatobiliary and gastrointestinal diseases].
abstract: Farnesoid X receptor (FXR), a bile acid receptor, serves as a member of the nuclear receptor superfamily. It plays a pivotal role in regulating hepatic inflammation and regeneration. Recent evidence suggests, that FXR and the bile acid are involved in diseases such as cholestatic and inflammatory liver diseases, hepatocellular carcinoma, and bacterial translocation. In this review we discuss the pathophysiology influence of FXR and the bile acid on liver, biliary and gastrointestinal diseases and its mechanisms.
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Xu
authors.forename: Cong
authors.initials: C
authors.lastname: Zhao
authors.forename: Yan-Ru
authors.initials: YR
authors.lastname: Yin
mesh_terms: D001647:Bile Acids and Salts / Q000502:physiology*; D001660:Biliary Tract Diseases; D006528:Carcinoma, Hepatocellular; D005767:Gastrointestinal Diseases; D006801:Humans; D008107:Liver Diseases; D008113:Liver Neoplasms; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D001647:Bile Acids and Salts; D018160:Receptors, Cytoplasmic and Nuclear; D000099150:Receptor, Farnesoid X-Activated