title: Everything you need to know about distal renal tubular acidosis in autoimmune disease.
abstract: Renal acid-base homeostasis is a complex process, effectuated by bicarbonate reabsorption and acid secretion. Impairment of urinary acidification is called renal tubular acidosis (RTA). Distal renal tubular acidosis (dRTA) is the most common form of the RTA syndromes. Multiple pathophysiologic mechanisms, each associated with various etiologies, can lead to dRTA. The most important consequence of dRTA is (recurrent) nephrolithiasis. The diagnosis is based on a urinary acidification test. Potassium citrate is the treatment of choice.
authors.affiliation: Division of Clinical Immunology, Department of Internal Medicine, Erasmus Medical Centre, PO Box 2040, Room D-XXX, 3000 CA, Rotterdam, The Netherlands, t.both.1@erasmusmc.nl.
authors.forename: Tim
authors.initials: T
authors.lastname: Both
authors.forename: Robert
authors.initials: R
authors.lastname: Zietse
authors.forename: Ewout J
authors.initials: EJ
authors.lastname: Hoorn
authors.forename: P Martin
authors.initials: PM
authors.lastname: van Hagen
authors.forename: Virgil A S H
authors.initials: VA
authors.lastname: Dalm
authors.forename: Jan A M
authors.initials: JA
authors.lastname: van Laar
authors.forename: Paul L A
authors.initials: PL
authors.lastname: van Daele
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects; D000141:Acidosis, Renal Tubular / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D000818:Animals; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D015551:Autoimmunity; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007686:Kidney Tubules, Distal / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D053040:Nephrolithiasis / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D019357:Potassium Citrate / Q000627:therapeutic use; D011237:Predictive Value of Tests; D012307:Risk Factors; D016896:Treatment Outcome; D016482:Urinalysis
chemical_list: D019357:Potassium Citrate