title: Lamotrigine in the treatment of psychotic depression associated with hereditary coproporphyria -- case report and a brief review of the literature.
abstract: OBJECTIVE
  We report a successful treatment with lamotrigine of a patient with hereditary coproporphyria presenting with affective and psychotic symptoms.
  
  
  METHODS
  M.F., a 38-year-old, single woman was admitted to an acute psychiatric ward because of suddenly emerging psychosis. Ms F's hereditary coproporphyria was diagnosed 9 years before the current admission. While on treatment with olanzapine (20mg/day) the psychotic symptoms have gradually disappeared. In view of her significant mood fluctuations predominantly with depressed phases, lamotrigine was started and titrated up to 125 mg/day. Ms F's mood gradually became euthymic, suicidal ideations and anxiety disappeared. At 5-month follow-up, while still on lamotrigine, her porphyria was asymptomatic.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first report about the safe administration of lamotrigine in hereditary coproporphyria. Lamotrigine did not trigger an acute porphyric attack as confirmed by clinical and laboratory findings.
authors.affiliation: Nyírő Gyula Hospital, 1st Department of Psychiatry, Budapest, Hungary. gazdag@lamb.hu.
authors.forename: Rozália
authors.initials: R
authors.lastname: Takács
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Makkos
authors.forename: Ákos
authors.initials: Á
authors.lastname: Kassai-Farkas
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Pusztai
authors.forename: Gábor S
authors.initials: GS
authors.lastname: Ungvári
authors.forename: Gábor
authors.initials: G
authors.lastname: Gazdag
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D046349:Coproporphyria, Hereditary / Q000150:complications*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome; D014227:Triazines / Q000627:therapeutic use*
chemical_list: D014150:Antipsychotic Agents; D014227:Triazines; D000077213:Lamotrigine