title: Tremella Polysaccharides attenuated sepsis through inhibiting abnormal CD4⁺CD25(high) regulatory T cells in mice.
abstract: Tremella Polysaccharides (TPS) have been reported to play an important role in regulating immune responses. Tregs are widely identified as the critical reason for immune dysfunction during sepsis. However, whether TPS could influence the immunomodulatory activities of Tregs in post-burn sepsis mice remains unclear. In this experiment, we researched the effects of TPS on peripheral blood Tregs in sepsis mouse induced by burn plus Pseudomonas aeruginosa infection. Results showed that TPS reversed the influences of Tregs on CD4⁺T cells proliferation and polarization and declined the level of IL-10 in burn plus P. aeruginosa infection mice. In addition, TPS notably reduced the mortality of post-burn sepsis mice. Therefore, TPS could inhibit the abnormal activities of CD4⁺CD25(high) Tregs in burn with P. aeruginosa infection mice, at least in part via inhibiting IL-10 secretion, and trigger a shift of Th2 to Th1 with activation of CD4⁺T cells in burn with P. aeruginosa infection mice.
authors.affiliation: Department of Nephrology, China Meitan General Hospital, Beijing 100028, PR China.
authors.forename: Zhen-wei
authors.initials: ZW
authors.lastname: Shi
authors.affiliation: Department of Nephrology, China Meitan General Hospital, Beijing 100028, PR China; Hebei United University, Tangshan, Hebei 063000, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Nephrology, China Meitan General Hospital, Beijing 100028, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Nephrology, China Meitan General Hospital, Beijing 100028, PR China.
authors.forename: Yu-rong
authors.initials: YR
authors.lastname: Hong
authors.affiliation: Department of Nephrology, China Meitan General Hospital, Beijing 100028, PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Nephrology, China Meitan General Hospital, Beijing 100028, PR China.
authors.forename: Xiao-lu
authors.initials: XL
authors.lastname: Li
authors.affiliation: Department of Nephrology, China Meitan General Hospital, Beijing 100028, PR China. Electronic address: wangzhigang1666@gmail.com.
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Wang
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry; D002056:Burns / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D015704:CD4 Antigens / Q000235:genetics / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D062610:Fungal Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D015870:Gene Expression; D007155:Immunologic Factors / Q000302:isolation & purification / Q000494:pharmacology*; D016753:Interleukin-10 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D053645:Interleukin-2 Receptor alpha Subunit / Q000235:genetics / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D058408:Th1-Th2 Balance
chemical_list: D015704:CD4 Antigens; D062610:Fungal Polysaccharides; C556062:IL10 protein, mouse; C508017:IL2RA protein, human; D007155:Immunologic Factors; D053645:Interleukin-2 Receptor alpha Subunit; D016753:Interleukin-10
keywords: Burn; CD4(+)CD25(high)Tregs; IL-10; Sepsis; Tremella Polysaccharides