title: The role of filaggrin in the skin barrier and disease development.
abstract: Filaggrin is a structural protein that is fundamental in the development and maintenance of the skin barrier. The function of filaggrin and its involvement in various cutaneous and extracutaneous disorders has been the subject of considerable research in recent years. Mutations in FLG, the gene that encodes filaggrin, have been shown to cause ichthyosis vulgaris, increase the risk of atopic dermatitis and other atopic diseases, and exacerbate certain conditions. The present article reviews the current knowledge on the role of filaggrin in the skin barrier, FLG mutations, and the consequences of filaggrin deficiency.
authors.affiliation: Servicio de Dermatología, Hospital Infantil Niño Jesús, Madrid, España. Electronic address: miquelarmengot@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Armengot-Carbo
authors.affiliation: Servicio de Dermatología, Hospital Infantil Niño Jesús, Madrid, España.
authors.forename: Á
authors.initials: Á
authors.lastname: Hernández-Martín
authors.affiliation: Servicio de Dermatología, Hospital Infantil Niño Jesús, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Torrelo
mesh_terms: D000091344:Filaggrin Proteins; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D012871:Skin Diseases / Q000209:etiology*; D012879:Skin Physiological Phenomena
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins
keywords: Allergic rhinitis; Asma; Asthma; Atopic dermatitis; Dermatitis atópica; Epidermis; Filaggrin; Filagrina; Ichthyosis vulgaris; Ictiosis vulgar; Rinitis alérgica