title: [Prevalence and clinical significance of interactions drug-enteral nutrition in Intensive Care Units].
abstract: This is a multicenter, cross-sectional retrospective study, which aimed to determine the prevalence of interactions drug-enteral nutrition (EN) in Intensive Care Units (ICU) of seven teaching hospitals in Brazil, and to analyze the clinical significance of them. Information on medications and EN administered with 24 hours and 120 hours of hospitalization were collected. For identification of drug-EN interaction was employed software Drug Reax®. It was investigated 1.124 records. Of these, 320 patients, with 24 hours of hospitalization, were on EN, and 20 (6.3%) had drug-EN interaction. Of the 504 patients with 120 hours of hospitalization, 39 (7.7%) had drug-EN interaction. The most frequent drug-EN interactions of clinical significance were phenytoin-EN, warfarin-EN and levothyroxine-EN. Drug-EN interactions may interfere with the quality and cost effectiveness of care in ICU, so it is essential that the health team has knowledge about them.
authors.affiliation: Departamento de Produtos Farmaceuticos, Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Adriano Max Moreira
authors.initials: AM
authors.lastname: Reis
authors.affiliation: Departamento de Enfermagem, Universidade Estadual do Ceara, Fortaleza, CE, Brasil.
authors.forename: Rhanna Emanuela Fontenele Lima
authors.initials: RE
authors.lastname: de Carvalho
authors.affiliation: Organizacao de Procura de Orgaos, Central de Transplantes do Estado de Goias, Secretaria de Estado da Saude de Goias, Goiania, GO, Brasil.
authors.forename: Leila Marcia Pereira
authors.initials: LM
authors.lastname: de Faria
authors.affiliation: Departamento de Enfermagem Medico-Cirurgica, Faculdade de Enfermagem Nossa Senhora das Gracas, Universidade de Pernambuco, Recife, PE, Brasil.
authors.forename: Regina Célia
authors.initials: RC
authors.lastname: de Oliveira
authors.affiliation: Unidade de Terapia Intensiva Adulta, Hospital de Clinicas, Universidade Federal de Uberlandia, Uberlandia, MG, Brasil.
authors.forename: Karine Santana de Azevedo
authors.initials: KS
authors.lastname: Zago
authors.affiliation: Escola de Enfermagem de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil.
authors.forename: Milena Ferreira
authors.initials: MF
authors.lastname: Cavelagna
authors.affiliation: Departamento de Enfermagem, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.
authors.forename: Adriano Gomes
authors.initials: AG
authors.lastname: Silva
authors.affiliation: Escola Superior de Ciencias da Saude, Universidade do Estado do Amazonas, Manaus, AM, Brasil.
authors.forename: Manoel Luis
authors.initials: ML
authors.lastname: Neto
authors.affiliation: Departamento de Enfermagem Geral e Especializada, Escola de Enfermagem de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil.
authors.forename: Silvia Helena de Bortoli
authors.initials: SH
authors.lastname: Cassiani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D004750:Enteral Nutrition; D005260:Female; D018565:Food-Drug Interactions; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult