title: Metabolic syndrome, insulin resistance, circadian disruption, antioxidants and pancreatic carcinoma: an overview.
abstract: The incidence and number of deaths caused by pancreatic tumours have been gradually rising, while the incidence and mortality of other common cancers have been declining. Risk factors for this malignant disease include cigarette smoking, family history of chronic pancreatitis, advancing age, male sex, diabetes mellitus, obesity, non-0 blood group, a high-fat diet, alcohol consumption and possibly Helicobacter pylori and hepatitis B virus infections. Metabolic diseases have become the leading cause of death in many countries. Our paper serves as a focused and updated discussion about the development of novel preventive strategies for this deadly disease.
authors.affiliation: Epidemiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale - IRCCS - Naples, Italy. epidemiologia.int@alice.it.
authors.forename: Aldo
authors.initials: A
authors.lastname: Giudice
authors.affiliation: Epidemiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale - IRCCS - Naples, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Crispo
authors.affiliation: Department of Experimental Medicine II University of Naples, Italy.
authors.forename: Galdiero
authors.initials: G
authors.lastname: Massimiliano
authors.affiliation: Department of Onco- Hematology, IRCCS Centro di Riferimento Oncologico della Basilicata,Rionero in Vulture, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: D'Arena
authors.affiliation: Department of Pharmacy, University of Salerno, Salerno, Italy.
authors.forename: Mario Felice
authors.initials: MF
authors.lastname: Tecce
authors.affiliation: Epidemiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale - IRCCS - Naples, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Grimaldi
authors.affiliation: Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale - IRCCS, Naples, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Amore
authors.affiliation: Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale - IRCCS, Naples Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Esposito
authors.affiliation: Epidemiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale - IRCCS - Naples, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Montella
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage*; D021081:Chronobiology Disorders / Q000150:complications* / Q000503:physiopathology; D057906:Circadian Clocks / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000150:complications* / Q000503:physiopathology; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D012307:Risk Factors
chemical_list: D000975:Antioxidants