title: Chromoendoscopy and Advanced Imaging Technologies for Surveillance of Patients with IBD.
abstract: Inflammatory bowel disease patients with long-standing colitis have an increased risk of colorectal cancer. The high rate of interval colitis-associated cancers among patients who adhere to a nontargeted, random biopsy surveillance strategy underlies the need for improved methods of early dysplasia detection. Compelling evidence supports the efficacy of chromoendoscopy for increasing the detection rate of dysplasia; however, this technology is currently underutilized in the clinical setting. Other contrast-based technologies-including confocal laser endomicroscopy (Pentax), endocytoscopy, multiband imaging, i-scan (Pentax), and molecular-targeted techniques-show promise in the detection of dysplasia in patients with inflammatory bowel disease. The strategies currently available for identifying patients with dysplasia or colitis-associated cancers remain inadequate and need to demonstrate both cost and time efficiency before they can be adopted in community-based practices.
authors.affiliation: Dr. Barkin is an Internal Medicine Resident at the University of Miami Leonard M. Miller School of Medicine and Jackson Memorial Hospital, both in Miami, Florida. Dr. Sussman is an Assistant Professor of Medicine in the Division of Gastroenterology at the University of Miami Leonard M. Miller School of Medicine in Miami, Florida. Dr. Abreu is a Professor of Medicine, a Professor of Microbiology and Immunology, and the Martin Kalser Chair in Gastroenterology at the University of Miami Leonard M. Miller School of Medicine in Miami, Florida.
authors.forename: Jodie A
authors.initials: JA
authors.lastname: Barkin
authors.affiliation: Dr. Barkin is an Internal Medicine Resident at the University of Miami Leonard M. Miller School of Medicine and Jackson Memorial Hospital, both in Miami, Florida. Dr. Sussman is an Assistant Professor of Medicine in the Division of Gastroenterology at the University of Miami Leonard M. Miller School of Medicine in Miami, Florida. Dr. Abreu is a Professor of Medicine, a Professor of Microbiology and Immunology, and the Martin Kalser Chair in Gastroenterology at the University of Miami Leonard M. Miller School of Medicine in Miami, Florida.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Sussman
authors.affiliation: Dr. Barkin is an Internal Medicine Resident at the University of Miami Leonard M. Miller School of Medicine and Jackson Memorial Hospital, both in Miami, Florida. Dr. Sussman is an Assistant Professor of Medicine in the Division of Gastroenterology at the University of Miami Leonard M. Miller School of Medicine in Miami, Florida. Dr. Abreu is a Professor of Medicine, a Professor of Microbiology and Immunology, and the Martin Kalser Chair in Gastroenterology at the University of Miami Leonard M. Miller School of Medicine in Miami, Florida.
authors.forename: Maria T
authors.initials: MT
authors.lastname: Abreu
keywords: Chromoendoscopy; confocal laser endomicroscopy; dysplasia; inflammatory bowel disease; narrow-band imaging; screening