title: Enhancing Cancer Drug Discovery through Novel Cell Signaling Pathway Panel Strategy.
abstract: The link between signaling pathways and diseases suggests the importance of pathway analysis for drug discovery. This includes target identification and validation, compound mode of action and drug candidate optimization. Here, we propose to apply cell signaling pathway panel approaches for oncology drug discovery. The strategies and guiding principles of the pathway panel approach are discussed. 2 pathway analysis examples with related processes and technology platforms are illustrated to identify cancer drugs that target cancer growth and metastasis. Finally, we highlight potential challenges and opportunities presented by the pathway panel approach.
authors.affiliation: Lead Evaluation and Mechanistic Biochemistry, Bristol Myers Squibb Company, Princeton, NJ.
authors.forename: Liang
authors.initials: L
authors.lastname: Schweizer
authors.affiliation: Lead Evaluation and Mechanistic Biochemistry, Bristol Myers Squibb Company, Princeton, NJ.
authors.forename: Litao
authors.initials: L
authors.lastname: Zhang
keywords: Wnt signaling; apoptosis; drug discovery; oncology; pathway panel; technology platform