title: Metal composition of fine particulate air pollution and acute changes in cardiorespiratory physiology.
abstract: BACKGROUND
  Studying the physiologic effects of components of fine particulate mass (PM2.5) could contribute to a better understanding of the nature of toxicity of air pollution.
  
  
  OBJECTIVE
  We examined the relation between acute changes in cardiovascular and respiratory function, and PM2.5-associated-metals.
  
  
  METHODS
  Using generalized linear mixed models, daily changes in ambient PM2.5-associated metals were compared to daily changes in physiologic measures in 59 healthy subjects who spent 5-days near a steel plant and 5-days on a college campus.
  
  
  RESULTS
  Interquartile increases in calcium, cadmium, lead, strontium, tin, vanadium and zinc were associated with statistically significant increases in heart rate of 1-3 beats per minute, increases of 1-3 mmHg in blood pressure and/or lung function decreases of up to 4% for total lung capacity.
  
  
  CONCLUSIONS
  Metals contained in PM2.5 were found to be associated with acute changes in cardiovascular and respiratory physiology.
authors.affiliation: Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada. Electronic address: sabit.cakmak@hc-sc.gc.ca.
authors.forename: Sabit
authors.initials: S
authors.lastname: Cakmak
authors.affiliation: Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Dales
authors.affiliation: Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada.
authors.forename: Lisa Marie
authors.initials: LM
authors.lastname: Kauri
authors.affiliation: Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada.
authors.forename: Mamun
authors.initials: M
authors.lastname: Mahmud
authors.affiliation: Water and Air Quality Bureau, Health Canada, Ottawa, Canada.
authors.forename: Keith
authors.initials: K
authors.lastname: Van Ryswyk
authors.affiliation: Texas Tech University, Department of Geosciences, Lubbock, TX, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Vanos
authors.affiliation: Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada.
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.affiliation: Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada.
authors.forename: Premkumari
authors.initials: P
authors.lastname: Kumarathasan
authors.affiliation: Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada.
authors.forename: Errol
authors.initials: E
authors.lastname: Thomson
authors.affiliation: Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada.
authors.forename: Renaud
authors.initials: R
authors.lastname: Vincent
authors.affiliation: Water and Air Quality Bureau, Health Canada, Ottawa, Canada.
authors.forename: Scott
authors.initials: S
authors.lastname: Weichenthal
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000032:analysis* / Q000633:toxicity; D000397:Air Pollution / Q000706:statistics & numerical data; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D008670:Metals / Q000032:analysis* / Q000633:toxicity; D052638:Particulate Matter / Q000032:analysis* / Q000633:toxicity; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000187:drug effects; D055815:Young Adult
chemical_list: D000393:Air Pollutants; D008670:Metals; D052638:Particulate Matter
keywords: Air pollution; Epidemiology; Fine particulate air pollution; Metals; Steel production