title: Pulmonary alveolar microlithiasis: report of two brothers with the same illness and review of literature.
abstract: Pulmonary alveolar microlithiasis (PAM) is a rare lung disease characterised by extensive deposition of calpospherites within the alveoli. The disease is caused by mutations in the gene SLC34A2 encoding sodium-dependent phosphate co-transporter. It is an autosomal recessive disease with sporadic cases worldwide. Most patients are asymptomatic at the time of diagnosis. It may progress slowly over years to respiratory failure and cor pulmonale.
authors.affiliation: Department of Medicine, Southend University Hospital, Southend-on-Sea, UK.
authors.forename: Hussain
authors.initials: H
authors.lastname: Al-Sardar
authors.forename: Dhaher J S
authors.initials: DJ
authors.lastname: Al-Habbo
authors.forename: Rami M A
authors.initials: RM
authors.lastname: Al-Hayali
mesh_terms: D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000235:genetics*; D030342:Genetic Diseases, Inborn / Q000000981:diagnostic imaging* / Q000235:genetics*; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D035781:Siblings; D050614:Sodium-Phosphate Cotransporter Proteins, Type IIb / Q000235:genetics
chemical_list: C493557:SLC34A2 protein, human; D050614:Sodium-Phosphate Cotransporter Proteins, Type IIb