title: [Goodpasture's disease: a case series].
abstract: Goodpasture's disease (GD) is an uncommon and severe autoimmune disorder caused by circulating autoantibodies directed against the glomerular basement membrane cross-reacting with the alveolar basement membrane. GD is clinically characterized by rapidly progressive glomerulonephritis, often associated with pulmonary hemorrhage representing a nephrological emergency. We present the clinical features of 9 cases, diagnosed in 1997-2012, in our Renal Unit. Contrary to previous reports, we found a predominance of GD in females and we observed unusual clinical patterns, such as the association with renal vein thrombosis in a pregnant patient, thrombosis of the pulmonary arteries and a late isolated recurrence of alveolitis. In dialysis-dependent patients, renal transplantation can represent an available treatment option.
authors.forename: Mauro
authors.initials: M
authors.lastname: Dugo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pasi
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Gatti
authors.forename: Stefania
authors.initials: S
authors.lastname: Mastrosimone
authors.forename: Licia
authors.initials: L
authors.lastname: Laurino
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Barberio
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Farneti
authors.forename: Cesarina
authors.initials: C
authors.lastname: Facchini
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Maresca
mesh_terms: D000328:Adult; D000368:Aged; D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult