title: Autologous haematopoietic stem cell mobilisation in multiple myeloma and lymphoma patients: a position statement from the European Group for Blood and Marrow Transplantation.
abstract: Autologous haematopoietic SCT with PBSCs is regularly used to restore BM function in patients with multiple myeloma or lymphoma after myeloablative chemotherapy. Twenty-eight experts from the European Group for Blood and Marrow Transplantation developed a position statement on the best approaches to mobilising PBSCs and on possibilities of optimising graft yields in patients who mobilise poorly. Choosing the appropriate mobilisation regimen, based on patients' disease stage and condition, and optimising the apheresis protocol can improve mobilisation outcomes. Several factors may influence mobilisation outcomes, including older age, a more advanced disease stage, the type of prior chemotherapy (e.g., fludarabine or melphalan), prior irradiation or a higher number of prior treatment lines. The most robust predictive factor for poor PBSC collection is the CD34(+) cell count in PB before apheresis. Determination of the CD34(+) cell count in PB before apheresis helps to identify patients at risk of poor PBSC collection and allows pre-emptive intervention to rescue mobilisation in these patients. Such a proactive approach might help to overcome deficiencies in stem cell mobilisation and offers a rationale for the use of novel mobilisation agents.
authors.affiliation: Department of Haematology, Saint Antoine Hospital, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Mohty
authors.affiliation: University Hospital Cologne, Cologne, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Hübel
authors.affiliation: University Hospital Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Kröger
authors.affiliation: King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabi.
authors.forename: M
authors.initials: M
authors.lastname: Aljurf
authors.affiliation: Imperial College London, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Apperley
authors.affiliation: The Medical University of Warsaw, Warsaw, Poland.
authors.forename: G W
authors.initials: GW
authors.lastname: Basak
authors.affiliation: American University of Beirut, Beirut, Lebanon.
authors.forename: A
authors.initials: A
authors.lastname: Bazarbachi
authors.affiliation: Beatson West of Scotland Cancer Centre, Glasgow, UK.
authors.forename: K
authors.initials: K
authors.lastname: Douglas
authors.affiliation: Imperial College London, London, UK.
authors.forename: I
authors.initials: I
authors.lastname: Gabriel
authors.affiliation: Department of Haematology, Saint Antoine Hospital, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Garderet
authors.affiliation: University Hospital Coimbra, Coimbra, Portugal.
authors.forename: C
authors.initials: C
authors.lastname: Geraldes
authors.affiliation: University Hospital Dubrava, Zagreb, Croatia.
authors.forename: O
authors.initials: O
authors.lastname: Jaksic
authors.affiliation: Quantitative Health Sciences Cleveland Clinic, Cleveland, OH, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Kattan
authors.affiliation: Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic.
authors.forename: Z
authors.initials: Z
authors.lastname: Koristek
authors.affiliation: Cremona Hospital, Cremona, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Lanza
authors.affiliation: University of Genoa, Genoa, Italy.
authors.forename: R M
authors.initials: RM
authors.lastname: Lemoli
authors.affiliation: National Research Centre for Haematology, Moscow, Russia.
authors.forename: L
authors.initials: L
authors.lastname: Mendeleeva
authors.affiliation: St Istvan and St Laszlo Hospital, Budapest, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Mikala
authors.affiliation: Institute of Children Haematology and Transplantation n.a. R Gorbacheva, St Petersburg State Pavlov Medical University, St Petersburg, Russia.
authors.forename: N
authors.initials: N
authors.lastname: Mikhailova
authors.affiliation: Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Nagler
authors.affiliation: Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: H C
authors.initials: HC
authors.lastname: Schouten
authors.affiliation: Department of Haematology, AZ Sint-Jan, Brugge-Oostende, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Selleslag
authors.affiliation: EORTC Headquarters, Brussels, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Suciu
authors.affiliation: Addenbrooke's Hospital, Cambridge, UK.
authors.forename: A
authors.initials: A
authors.lastname: Sureda
authors.affiliation: Medical University Vienna, Vienna, Austria.
authors.forename: N
authors.initials: N
authors.lastname: Worel
authors.affiliation: Department of Medicine V, Heidelberg University, Heidelberg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Wuchter
authors.affiliation: Institut Paoli-Calmettes and Inserm CBT-510, Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Chabannon
authors.affiliation: Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: R F
authors.initials: RF
authors.lastname: Duarte
mesh_terms: D005060:Europe; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006801:Humans; D008223:Lymphoma / Q000628:therapy*; D009101:Multiple Myeloma / Q000628:therapy*; D014182:Transplantation, Autologous