title: Curcuma Contra Cancer? Curcumin and Hodgkin's Lymphoma.
abstract: Curcumin, a phytochemical isolated from curcuma plants which are used as coloring ingredient for the preparation of curry powder, has several activities which suggest that it might be an interesting drug for the treatment or prevention of cancer. Curcumin targets different pathways which are involved in the malignant phenotype of tumor cells, including the nuclear factor kappa B (NFKB) pathway. This pathway is deregulated in multiple tumor entities, including Hodgkin's lymphoma (HL). Indeed, curcumin can inhibit growth of HL cell lines and increases the sensitivity of these cells for cisplatin. In this review we summarize curcumin activities with special focus on possible activities against HL cells.
authors.affiliation: Martin-Luther-University Halle-Wittenberg, University Clinic and Polyclinic for Child and Adolescent Medicine, Halle, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Kewitz
authors.affiliation: Martin-Luther-University Halle-Wittenberg, University Clinic and Polyclinic for Child and Adolescent Medicine, Halle, Germany.
authors.forename: Ines
authors.initials: I
authors.lastname: Volkmer
authors.affiliation: Martin-Luther-University Halle-Wittenberg, University Clinic and Polyclinic for Child and Adolescent Medicine, Halle, Germany.
authors.forename: Martin S
authors.initials: MS
authors.lastname: Staege
keywords: Hodgkin’s lymphoma; cancer; curcumin; nuclear factor kappa B; vitamin D receptor