title: Ozone as an adjunct to conventional nonsurgical therapy in chronic periodontitis: a randomized controlled clinical trial.
abstract: OBJECTIVE
  Currently, only limited data are available from controlled clinical trials regarding the effect of irrigation by ozonated water in the treatment of periodontitis. The aim of the present study was to determine the clinical and biological effects of the adjunctive use of ozone in nonsurgical periodontal treatment.
  
  
  METHODS
  Forty-one patients with chronic periodontitis were randomized to treatment with either subgingival scaling and root planing (SRP) followed by irrigation with ozonated water (test) or subgingival SRP followed by irrigation with distilled water irrigation (control). The following parameters were evaluated at baseline (T0), 3 mo (T1): plaque index; gingival index; bleeding on probing; probing pocket depth; gingival recession; and clinical attachment loss. In addition, the serum concentrations of high sensitivity C-reactive protein were measured at T0 and T1.
  
  
  RESULTS
  Forty-one patients with chronic periodontitis were included in the analysis (20 in the test group and 21 in the control group). There was statistically significant improvement in the study parameters in both groups between T0 and T1, except for gingival index. However, there were no significant differences in any study parameter between test and control groups.
  
  
  CONCLUSIONS
  Irrigation with ozonated water as an adjunctive therapy to SRP produces no statistically significant benefit compared with SRP plus distilled water irrigation.
authors.affiliation: Department of Preventive Dentistry, Jordan University of Science and Technology, Irbid, Jordan.
authors.forename: R
authors.initials: R
authors.lastname: Al Habashneh
authors.forename: W
authors.initials: W
authors.lastname: Alsalman
authors.forename: Y
authors.initials: Y
authors.lastname: Khader
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000032:analysis; D055113:Chronic Periodontitis / Q000628:therapy*; D003131:Combined Modality Therapy; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000145:classification / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010126:Ozone / Q000008:administration & dosage / Q000627:therapeutic use*; D017622:Periodontal Attachment Loss / Q000145:classification / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification / Q000628:therapy; D016745:Root Planing / Q000379:methods*; D007507:Therapeutic Irrigation / Q000379:methods; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D010126:Ozone; D002097:C-Reactive Protein
keywords: antimicrobial; dental plaque; gingival index; imflammatory mediator; periodontitis; treatment