title: Quantifying the uncertainty in heritability.
abstract: The use of mixed models to determine narrow-sense heritability and related quantities such as SNP heritability has received much recent attention. Less attention has been paid to the inherent variability in these estimates. One approach for quantifying variability in estimates of heritability is a frequentist approach, in which heritability is estimated using maximum likelihood and its variance is quantified through an asymptotic normal approximation. An alternative approach is to quantify the uncertainty in heritability through its Bayesian posterior distribution. In this paper, we develop the latter approach, make it computationally efficient and compare it to the frequentist approach. We show theoretically that, for a sufficiently large sample size and intermediate values of heritability, the two approaches provide similar results. Using the Atherosclerosis Risk in Communities cohort, we show empirically that the two approaches can give different results and that the variance/uncertainty can remain large.
authors.affiliation: 1] Microsoft Research, Los Angeles, CA, USA [2] Computer Science Department, University of California, Los Angeles, CA, USA.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Furlotte
authors.affiliation: Microsoft Research, Los Angeles, CA, USA.
authors.forename: David
authors.initials: D
authors.lastname: Heckerman
authors.affiliation: Microsoft Research, Los Angeles, CA, USA.
authors.forename: Christoph
authors.initials: C
authors.lastname: Lippert
mesh_terms: D000465:Algorithms; D050197:Atherosclerosis / Q000235:genetics; D001499:Bayes Theorem; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D008957:Models, Genetic; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable; D044469:Racial Groups / Q000235:genetics; D012307:Risk Factors; D035501:Uncertainty