title: [Effects of non-surgical periodontal treatment on clinical response, serum inflammatory parameters, and metabolic control of type 2 diabetes patients with moderate to severe periodontitis].
abstract: OBJECTIVE
  To evaluate the effects of periodontal treatment on the clinical response, systemic inflammatory parameters, and metabolic control of type 2 diabetes patients with moderate to severe periodontitis.
  
  
  METHODS
  A total of 56 patients with mean clinical attachment level (CAL)>3 mm were included in the subgroup analysis. A repeated-measures ANOVA (group factor: treatment group and control group; time factor: initial visit, 1.5, 3, and 6 months) was used to analyze the probing depth (PD), CAL, bleeding on probing (BOP), high-sensitivity C-reactive protein (hsCRP), glycated hemoglobin (HbA1c), and fasting plasma glucose.
  
  
  RESULTS
  Significantly lower PD (F=62.898, P-0.000), CAL (F=51.263, P-0.000), BOP (F=75.164, P=0.000), hsCRP (F=6.391, P=0.010), HbA1c(F=4.536, P=0.011), and fasting plasma glucose level (F= 3.073, P=0.031) were observed after therapeutic periodontal improvement. The inter-group differences for PD (t=-2.050, P=0.045), BOP (t=-4.538, P=0.000), and hsCRP (t=-2.261, P=0.028) were statistically significant after therapy.
  
  
  CONCLUSIONS
  Non-surgical periodontal treatment can effectively improve periodontal status, circulating inflammatory status, and metabolic control of diabetic patients with moderate to severe periodontitis.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Su
authors.forename: Jia
authors.initials: J
authors.lastname: Ni
authors.forename: Wei
authors.initials: W
authors.lastname: Luo
authors.forename: Dong-ying
authors.initials: DY
authors.lastname: Xuan
authors.forename: Jincai
authors.initials: J
authors.lastname: Zhang
mesh_terms: D002097:C-Reactive Protein; D055113:Chronic Periodontitis; D003924:Diabetes Mellitus, Type 2; D006442:Glycated Hemoglobin; D006801:Humans; D010518:Periodontitis
chemical_list: D002097:C-Reactive Protein; D006442:Glycated Hemoglobin