title: Polysomnographic differences associated with pulmonary hypertension in patients with advanced lung disease due to cystic fibrosis.
abstract: BACKGROUND
  Pulmonary hypertension (PH) commonly occurs in patients with cystic fibrosis (CF), but there is no current data regarding alterations of sleep in patients with PH.
  
  
  METHODS
  A single-center, retrospective review was performed in patients with advanced lung disease due to CF who completed both nocturnal polysomnography and right heart catheterization (RHC) from January 2010 to June 2013. For statistical analysis, two-tailed unpaired t tests and Pearson correlation coefficient analysis were performed after normal distribution was confirmed.
  
  
  RESULTS
  A total of 18 consecutive CF patients were enrolled with RHC identifying PH in 56 % (10/18) of patients. The PH group had significantly lower mean sleep efficiency (72 ± 4 vs. 87 ± 3 %, p = 0.01), significantly higher ETCO(2) levels (54.5 ± 2.2 vs. 43.8 ± 3.0 mmHg, p = 0.01) on capnography, and significantly lower PO(2) (53.8 ± 3.1 vs. 65.5 ± 3.9 mmHg, p = 0.03) on capillary blood gas. Correlations with poor sleep efficiency included mean PAP (r = - 0.55, p = 0.01), systolic PAP (r = -0.5, p = 0.03), ETCO(2) (r = - 0.53, p = 0.02), and PO(2)) (r = 0.62, p = 0.01); ETCO(2) with systolic PAP (r = 0.47, p = 0.04) and PCO(2) (r = - 0.57, p = 0.01); and PO(2) to 6-min walk distance (r = 0.55, p = 0.02).
  
  
  CONCLUSIONS
  We found significant differences in sleep efficiency and gas exchange associated with PH in CF patients with advanced lung disease.
authors.affiliation: Department of Pediatrics, The Ohio State University, Columbus, OH, USA, hayes.705@osu.edu.
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
authors.forename: Curt J
authors.initials: CJ
authors.lastname: Daniels
authors.forename: Stephen
authors.initials: S
authors.lastname: Kirkby
authors.forename: Benjamin T
authors.initials: BT
authors.lastname: Kopp
authors.forename: Kerri L
authors.initials: KL
authors.lastname: Nicholson
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Nance
authors.forename: Mark L
authors.initials: ML
authors.lastname: Splaingard
mesh_terms: D000328:Adult; D062186:Arterial Pressure; D001784:Blood Gas Analysis; D019296:Capnography; D006328:Cardiac Catheterization; D003550:Cystic Fibrosis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008168:Lung / Q000503:physiopathology*; D008297:Male; D009820:Ohio; D010865:Pilot Projects; D017286:Polysomnography; D011237:Predictive Value of Tests; D011651:Pulmonary Artery / Q000503:physiopathology; D011659:Pulmonary Gas Exchange; D012189:Retrospective Studies; D012307:Risk Factors; D012890:Sleep; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology