title: Secretion of interleukin-17 by CD8+ T cells expressing CD146 (MCAM).
abstract: Interleukin-17 (IL-17) has been associated with the pathogenesis of numerous autoimmune diseases. CD4+ T cells secreting IL-17 are termed Th17 cells. CD8+ T cells, designated Tc17 cells, are also capable of secreting IL-17. Here we describe a population of Tc17 cells characterized by the expression of surface CD146, an endothelial adhesion molecule. These cells display signatures of a human Tc17 genotype and phenotype. Circulating CD8+CD146+ T cells are present in low levels in healthy adults. Elevations in CD8+CD146+ T cells are found in Behcet's disease and birdshot retinochoroidopathy, which have been reported to have HLA class I associations. Sarcoidosis does not have a class I association and displays an increase in CD4+ CD146+ T cells but not in CD8+CD146+ T cells. CD146 on these cells may facilitate their ability to bind to, and migrate through, endothelium, as has been reported for CD4+CD146+ T cells.
authors.affiliation: Hematology Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
authors.forename: Pradeep K
authors.initials: PK
authors.lastname: Dagur
authors.affiliation: Center for Human Immunology, Autoimmunity and Inflammation, NIH, Bethesda, MD 20892, USA.
authors.forename: Angélique
authors.initials: A
authors.lastname: Biancotto
authors.affiliation: Hematology Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
authors.forename: Elena
authors.initials: E
authors.lastname: Stansky
authors.affiliation: Clinical Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: H Nida
authors.initials: HN
authors.lastname: Sen
authors.affiliation: Center for Human Immunology, Autoimmunity and Inflammation, NIH, Bethesda, MD 20892, USA; Clinical Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nussenblatt
authors.affiliation: Hematology Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA; Center for Human Immunology, Autoimmunity and Inflammation, NIH, Bethesda, MD 20892, USA. Electronic address: mccoyjp@mail.nih.gov.
authors.forename: J Philip
authors.initials: JP
authors.lastname: McCoy
mesh_terms: D001528:Behcet Syndrome / Q000276:immunology*; D000080365:Birdshot Chorioretinopathy; D051929:CD146 Antigen / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002825:Chorioretinitis / Q000276:immunology*; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D012507:Sarcoidosis / Q000276:immunology*
chemical_list: D051929:CD146 Antigen; D020381:Interleukin-17
keywords: CD146/MCAM; Class I antigen; Inflammation; Tc17