title: Orchestration of cell surface proteins by Rab11.
abstract: The organization of cells into interconnected structures such as animal tissues requires a sophisticated system directing receptors and adhesion proteins to the cell surface. The Rab11 small G proteins (Rab11a, b, and Rab25) of the Ras superfamily are master regulators of the surface expression of receptors and adhesion proteins. Acting as a molecular switch, Rab11 builds distinct molecular machinery such as motor protein complexes and the exocyst to transport proteins to the cell surface. Recent evidence reveals Rab11 localization at the trans-Golgi network (TGN), post-Golgi vesicles, and the recycling endosome, placing it at the intersection between the endocytic and exocytic trafficking pathways. We review Rab11 in various cellular contexts, and discuss its regulation and mechanisms by which Rab11 couples with effector proteins.
authors.affiliation: Molecular Cell Biology Laboratory, Department of Neurology, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, Regensburg, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Welz
authors.affiliation: Molecular Cell Biology Laboratory, Department of Neurology, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, Regensburg, Germany.
authors.forename: Joel
authors.initials: J
authors.lastname: Wellbourne-Wood
authors.affiliation: Molecular Cell Biology Laboratory, Department of Neurology, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, Regensburg, Germany. Electronic address: eugen.kerkhoff@klinik.uni-regensburg.de.
authors.forename: Eugen
authors.initials: E
authors.lastname: Kerkhoff
mesh_terms: D000818:Animals; D011992:Endosomes / Q000378:metabolism / Q000502:physiology; D006056:Golgi Apparatus / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D020691:rab GTP-Binding Proteins / Q000378:metabolism*; D021601:trans-Golgi Network / Q000378:metabolism / Q000502:physiology; D000099193:rab11 GTP-Binding Proteins
chemical_list: D008565:Membrane Proteins; D020691:rab GTP-Binding Proteins; D000099193:rab11 GTP-Binding Proteins
keywords: Crag-DENN; Evi5-TBC; Rab11; Rab11-FIP; motor proteins; protruding