title: Primary immunodeficiency investigation in patients during and after hospitalization in a pediatric intensive care unit.
abstract: OBJECTIVE
  To analyze whether the patients with severe infections, admitted in the Pediatric Intensive Care Unit of the Hospital de Clínicas of the Universidade Federal de Uberlândia, underwent the active screening for primary immunodeficiencies (PID).
  
  
  METHODS
  Retrospective study that assessed the data records of patients with any severe infections admitted in the Pediatric Intensive Care Unit, covering a period from January 2011 to January 2012, in order to confirm if they performed an initial investigation for PID with blood count and immunoglobulin dosage.
  
  
  RESULTS
  In the studied period, 53 children were hospitalized with severe infections in the Pediatric Intensive Care Unit, and only in seven (13.2%) the initial investigation of PID was performed. Among these patients, 3/7 (42.8%) showed quantitative alterations in immunoglobulin G (IgG) levels, 1/7 (14.3%) had the diagnosis of cyclic neutropenia, and 1/7 (14.3%) presented thrombocytopenia and a final diagnosis of Wiskott-Aldrich syndrome. Therefore, the PID diagnosis was confirmed in 5/7 (71.4%) of the patients.
  
  
  CONCLUSIONS
  The investigation of PID in patients with severe infections has not been routinely performed in the Pediatric Intensive Care Unit. Our findings suggest the necessity of performing PID investigation in this group of patients.
authors.affiliation: Hospital de Clinicas, UFU, Uberlandia, MG, Brasil.
authors.forename: Érica
authors.initials: É
authors.lastname: Suavinho
authors.affiliation: Hospital de Clinicas, UFU, Uberlandia, MG, Brasil.
authors.forename: Ana Carolina R
authors.initials: AC
authors.lastname: de Nápolis
authors.affiliation: Departamento de Pediatria, UFU, Uberlandia, MG, Brasil.
authors.forename: Gesmar Rodrigues S
authors.initials: GR
authors.lastname: Segundo
mesh_terms: D001424:Bacterial Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006760:Hospitalization; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index