title: Chewing gum containing allyl isothiocyanate from mustard seed extract is effective in reducing volatile sulfur compounds responsible for oral malodor.
abstract: OBJECTIVE
  To evaluate the in vivo effect of chewing gum containing allyl isothiocyanate alone, and in combination with zinc salts on reduction of the level of volatile sulfur compounds responsible for oral malodor.
  
  
  METHODS
  15 healthy volunteers between the ages of 20-50 chewed either an experimental gum or a placebo gum for 12 minutes. Their mouth air was analyzed for volatile sulfur compounds by a gas chromatograph at baseline, immediately after chewing, and at 60, 120 and 180 minutes after treatment.
  
  
  RESULTS
  The study revealed that allyl isothiocyanate, a constituent of mustard seed extract, can effectively reduce the concentration of volatile sulfur compounds in mouth air. Chewing gum containing 0.1% zinc lactate and 0.01% of allyl isothiocyanate eliminated 89%, 55.5%, 48% and 24% of the total VSC concentration immediately after chewing and at 1, 2, and 3 hours after chewing, respectively.
authors.forename: Minmin
authors.initials: M
authors.lastname: Tian
authors.forename: Anthony Bryan
authors.initials: AB
authors.lastname: Hanley
authors.forename: Michael W J
authors.initials: MW
authors.lastname: Dodds
authors.forename: Ken
authors.initials: K
authors.lastname: Yaegaki
mesh_terms: D000328:Adult; D002638:Chewing Gum; D002849:Chromatography, Gas; D018592:Cross-Over Studies; D005260:Female; D005500:Follow-Up Studies; D006209:Halitosis / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D006862:Hydrogen Sulfide / Q000032:analysis; D017879:Isothiocyanates / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009149:Mustard Plant; D010919:Placebos; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D012639:Seeds; D016037:Single-Blind Method; D013438:Sulfhydryl Compounds / Q000032:analysis; D013997:Time Factors; D055549:Volatile Organic Compounds / Q000032:analysis; D055815:Young Adult; D017967:Zinc Compounds / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D002638:Chewing Gum; D017879:Isothiocyanates; D010919:Placebos; D010936:Plant Extracts; D013438:Sulfhydryl Compounds; D055549:Volatile Organic Compounds; D017967:Zinc Compounds; C005231:methylmercaptan; C004471:allyl isothiocyanate; D006862:Hydrogen Sulfide