title: The co-identity of lipiarmycin A3 and tiacumicin B.
abstract: The co-identity of the antibiotics lipiarmycin A3 obtained from Actinoplanes deccanensis and tiacumicin B obtained from Dactylosporangium aurantiacum was unambiguously demonstrated through a number of experimental means. Spectroscopic analyses performed on both the antibiotics themselves and on their derivatives showed no difference between the two series of compounds. Moreover, unambiguous confirmation of the postulated identity of the two compounds was achieved by chemical degradation of lipiarmycin A3 and isolation of (3S,4R)-pentane-1,3,4-triol triacetate whose relative configuration was assigned by comparison with the authentic erythro and threo pentane-1,3,4-triol triacetates, obtained by chemical synthesis.
authors.forename: Angelo
authors.initials: A
authors.lastname: Bedeschi
authors.forename: Piera
authors.initials: P
authors.lastname: Fonte
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fronza
authors.forename: Claudio
authors.initials: C
authors.lastname: Fuganti
authors.forename: Stefano
authors.initials: S
authors.lastname: Serra
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry / Q000302:isolation & purification*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D000077732:Fidaxomicin; D008968:Molecular Conformation
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000077732:Fidaxomicin