title: In vivo detection of inhalation injury in large airway using three-dimensional long-range swept-source optical coherence tomography.
abstract: We report on the feasibility of using long-range swept-source optical coherence tomography (OCT) to detect airway changes following smoke inhalation in a sheep model. The long-range OCT system (with axial imaging range of 25 mm) and probe are capable of rapidly obtaining a series of high-resolution full cross-sectional images and three-dimensional reconstructions covering 20-cm length of tracheal and bronchial airways with airway diameter up to 25 mm, regardless of the position of the probe within the airway lumen. Measurements of airway thickness were performed at baseline and postinjury to show mucosal thickness changes following smoke inhalation.
authors.affiliation: University of California, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612bOCT Medical Imaging Inc., 1002 Health Sciences Road East, Irvine, California 92612.
authors.forename: Lidek
authors.initials: L
authors.lastname: Chou
authors.affiliation: US Army Institute of Surgical Research, San Antonio Military Medical Center, Fort Sam Houston, San Antonio, Texas 78234.
authors.forename: Andriy
authors.initials: A
authors.lastname: Batchinsky
authors.affiliation: US Army Institute of Surgical Research, San Antonio Military Medical Center, Fort Sam Houston, San Antonio, Texas 78234.
authors.forename: Slava
authors.initials: S
authors.lastname: Belenkiy
authors.affiliation: University of California, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612dUniversity of California, Department of Biomedical Engineering, Irvine, California 92697.
authors.forename: Joseph
authors.initials: J
authors.lastname: Jing
authors.affiliation: OCT Medical Imaging Inc., 1002 Health Sciences Road East, Irvine, California 92612.
authors.forename: Tirunelveli
authors.initials: T
authors.lastname: Ramalingam
authors.affiliation: University of California, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612eUniversity of California, Irvine Medical Center, Division of Pulmonary and Critical Care, Orange, California 92868.
authors.forename: Matthew
authors.initials: M
authors.lastname: Brenner
authors.affiliation: University of California, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612dUniversity of California, Department of Biomedical Engineering, Irvine, California 92697.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000818:Animals; D001980:Bronchi / Q000473:pathology; D001999:Bronchoscopy; D021621:Imaging, Three-Dimensional / Q000379:methods*; D020545:Respiratory Mucosa / Q000473:pathology; D012756:Sheep; D015208:Smoke Inhalation Injury / Q000175:diagnosis* / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*