title: GWAS-identified common variants for obesity are not associated with the risk of developing colorectal cancer.
abstract: BACKGROUND
  Observational studies have consistently associated obesity with colorectal cancer risk. Because both traits are genetically determined and share some metabolic biomarkers, we hypothesized that obesity-related polymorphisms could also influence the risk of developing colorectal cancer.
  
  
  METHODS
  We conducted a comprehensive population-based case-control study in 1,792 German colorectal cancer cases and 1,805 controls to explore associations between 28 obesogenic variants identified through genome-wide association studies (GWAS) and colorectal cancer risk. We also evaluated interactions between polymorphisms and body mass index (BMI), type II diabetes (T2D), and gender.
  
  
  RESULTS
  No evidence of association between obesogenic variants and colorectal cancer risk was observed after correction for multiple testing. There was only a remarkable interaction between the LTArs1041981 polymorphism and gender, which modified the risk of colorectal cancer [Pinteraction = 0.002; males: odds ratio (OR), 1.14; 95% confidence intervals (CI), 1.00-1.30 vs. females: OR, 0.83; 95% CI, 0.71-0.97].
  
  
  CONCLUSIONS
  Our findings showed that obesogenic variants are not a major pathogenetic risk factor for colorectal cancer.
  
  
  CONCLUSIONS
  This comprehensive population-based case-control study does not provide evidence of a shared genetic component between obesity and colorectal cancer.
authors.affiliation: Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
authors.forename: Juan
authors.initials: J
authors.lastname: Sainz
authors.affiliation: Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
authors.forename: Bernd
authors.initials: B
authors.lastname: Frank
authors.affiliation: Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
authors.forename: Miguel I
authors.initials: MI
authors.lastname: da Silva Filho
authors.affiliation: Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
authors.forename: Michael
authors.initials: M
authors.lastname: Hoffmeister
authors.affiliation: Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
authors.forename: Anja
authors.initials: A
authors.lastname: Rudolph
authors.affiliation: Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
authors.forename: Katja
authors.initials: K
authors.lastname: Butterbach
authors.affiliation: Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
authors.forename: Jenny
authors.initials: J
authors.lastname: Chang-Claude
authors.affiliation: Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
authors.forename: Hermann
authors.initials: H
authors.lastname: Brenner
authors.affiliation: Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, SwedenAuthors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
authors.forename: Kari
authors.initials: K
authors.lastname: Hemminki
authors.affiliation: Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, SwedenAuthors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden A.Foersti@dkfz-heidelberg.de.
authors.forename: Asta
authors.initials: A
authors.lastname: Försti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D012307:Risk Factors