title: Is symmetric dimethylarginine a sensitive biomarker of subclinical kidney injury in children born with low birth weight?
abstract: OBJECTIVE
  The aim of this study was to investigate if Symmetric Dimethylarginine (SDMA) is a sensitive biomarker of renal function and may predict subclinical kidney injury in low birth weight (LBW) children.
  
  
  METHODS
  We studied 68 LBW children and 20 children as reference group. An enzyme-linked immunosorbent assay was used to measure serum SDMA and Cystatin C (Cys C).
  
  
  RESULTS
  SDMA levels were higher in study groups compared to reference groups. There was a strong correlation between SDMA and Cys C, also SDMA negatively correlated with eGFR.
  
  
  CONCLUSIONS
  Elevated SDMA concentration may play an important role in pathogenesis of chronic kidney disease.
authors.affiliation: Department of Pediatric Nephrology, Medical University of Bialystok , Bialystok , Poland.
authors.forename: Piotr Tomasz
authors.initials: PT
authors.lastname: Protas
authors.forename: Edyta
authors.initials: E
authors.lastname: Tenderenda-Banasiuk
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Taranta-Janusz
authors.forename: Renata
authors.initials: R
authors.lastname: Fiłonowicz
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zając
authors.forename: Anna
authors.initials: A
authors.lastname: Wasilewska
mesh_terms: D000293:Adolescent; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007668:Kidney / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C487735:dimethylarginine; D001120:Arginine