title: New chromone and triglyceride from Cucumis melo seeds.
abstract: Re-investigation of the MeOH extract of the seeds of Cucumis melo L. var. reticulatus (Cucurbitaceae) led to the isolation of a new chromone derivative (5,7- dihydroxy-2-[2-(3-methoxy-4-hydroxyphenyl)ethyl]chromone (5) and a triglyceride (1,3-di-(6Z,9Z)-docosa-6,9-dienoyl-2-(6Z) hexacos-6-enoylglycerol (1), together with three known compounds; alpha-spinasterol (2), stigmasta-7,22,25-trien-3-ol (3), and D:B-friedoolean-5-ene-3-beta-ol (4), are reported from this species for the first time. Their structures were determined by extensive 1D (1H, 13C, and DEPT) and 2D (1H-1H COSY, HMQC, and HMBC) NMR and mass spectral measurements. Compound 5 displayed significant cytotoxic activity against L5178Y cells, with an ED50 of 5 microM. The MeOH extract and 5 showed antioxidant activity using the DPPH assay.
authors.forename: Sabrin R M
authors.initials: SR
authors.lastname: Ibrahim
mesh_terms: D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification*; D028463:Cucumis melo / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000032:analysis; D012639:Seeds / Q000737:chemistry; D014280:Triglycerides / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D002867:Chromones; D010936:Plant Extracts; D014280:Triglycerides