title: [Lapatinib plus transtuzumab for HER-2 positiva metastatic breast cancer: experience of use].
abstract: OBJECTIVE
  To describe the outcomes produced by concomitant use of HER2-receptor inhibitors Lapatinib and Trastuzumab for the treatment of HER 2-positive metastatic breast cancer.
  
  
  METHODS
  Retrospective observational study. Patients treated with Trastuzumab and Lapatinib between January of 2010 and May of 2012 were selected. Demographical and clinical data were gathered.
  
  
  RESULTS
  23 patients with metastatic breast cancer (mean age 59.3 ± 13.3 years) were included. All of them had received an average of 5 treatment lines with at least one of them including Trastuzumab. The median progression-free survival rate with combined Lapatinib + Trastuzumab, with or without associated chemotherapy was 7 months (95% CI: 2.78-11.21) and 3 months for the patients only receiving Lapatinib and Trastuzumab. Seven patients experienced adverse events and in four patients the treatment was stopped due to toxicity.
  
  
  CONCLUSIONS
  The treatment with HER2-receptor inhibitors in our patients resulted in progression-free survival rates similar to those published in clinical trials with patients receiving Lapatinib + Trastuzumab not combined with any other anti-cancer therapy, with good treatment tolerability.
authors.affiliation: Servicio de Farmacia. Hospital Universitario 12 de Octubre. Madrid. España.. carmengarcia.m@hotmail.com.
authors.forename: C
authors.initials: C
authors.lastname: García-Muñoz
authors.affiliation: Servicio de Farmacia. Hospital Universitario 12 de Octubre. Madrid. España..
authors.forename: S
authors.initials: S
authors.lastname: Cortijo-Cascajares
authors.affiliation: Servicio de Farmacia. Hospital Universitario 12 de Octubre. Madrid. España..
authors.forename: I
authors.initials: I
authors.lastname: Cañamares-Orbis
authors.affiliation: Servicio de Farmacia. Hospital Universitario 12 de Octubre. Madrid. España..
authors.forename: M P
authors.initials: MP
authors.lastname: Goyache-Goñi
authors.affiliation: Servicio de Farmacia. Hospital Universitario 12 de Octubre. Madrid. España..
authors.forename: J M
authors.initials: JM
authors.lastname: Ferrari-Piquero
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D000077341:Lapatinib; D008875:Middle Aged; D011799:Quinazolines / Q000008:administration & dosage*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*; D012189:Retrospective Studies; D000068878:Trastuzumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000077341:Lapatinib; D011799:Quinazolines; D018719:Erb-b2 Receptor Tyrosine Kinases; D000068878:Trastuzumab; C508053:ERBB2 protein, human