title: Relationship between gut microbiota and development of T cell associated disease.
abstract: The interplay between the immune response and the gut microbiota is complex. Although it is well-established that the gut microbiota is essential for the proper development of the immune system, recent evidence indicates that the cells of the immune system also influence the composition of the gut microbiota. This interaction can have important consequences for the development of inflammatory diseases, including autoimmune diseases and allergy, and the specific mechanisms by which the gut commensals drive the development of different types of immune responses are beginning to be understood. Furthermore, sex hormones are now thought to play a novel role in this complex relationship, and collaborate with both the gut microbiota and immune system to influence the development of autoimmune disease. In this review, we will focus on recent studies that have transformed our understanding of the importance of the gut microbiota in inflammatory responses.
authors.affiliation: Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40205, USA.
authors.forename: Michele M
authors.initials: MM
authors.lastname: Kosiewicz
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of Louisville, Louisville, KY 40205, USA.
authors.forename: Gerald W
authors.initials: GW
authors.lastname: Dryden
authors.affiliation: Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40205, USA.
authors.forename: Anita
authors.initials: A
authors.lastname: Chhabra
authors.affiliation: Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40205, USA. Electronic address: p0alar01@louisville.edu.
authors.forename: Pascale
authors.initials: P
authors.lastname: Alard
mesh_terms: D000818:Animals; D004194:Disease; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology*; D006801:Humans; D007109:Immunity; D064307:Microbiota; D013601:T-Lymphocytes / Q000276:immunology
keywords: Androgen; Autoimmunity; DC; Gut microbiota; SCFA; Treg