title: The combined use of antimullerian hormone and age to predict the ovarian response to controlled ovarian hyperstimulation in poor responders: A novel approach.
abstract: BACKGROUND
  Reduced ovarian response to stimulation represents one of the most intractable problems in infertility treatment. As failed cycle can cause considerable amount of emotional and economical loss, there are various attempts made to predict ovarian response.
  
  
  OBJECTIVE
  To evaluate different factors influencing outcome of assisted reproduction in women with predicted reduced response (antimullerian hormone between 1 and 5 pmol/L) and to develop a model using of AMH and age to predict the number of oocytes in poor responders.
  
  
  METHODS
  Retrospective study in a teaching hospital.
  
  
  METHODS
  We analyzed 85 cycles (57 women) with predicted reduced response with serum AMH value between 1 and 5 pmol/L. Standard ovarian stimulation protocol was used. Primary outcome measures were clinical pregnancy rates and oocytes retrieved.
  
  
  METHODS
  Data were analyzed using Microsoft excel and MetlabR software.
  
  
  RESULTS
  Clinical pregnancy rate/ET was 20.33%, in this group. AMH and age was analyzed using linear regression model which produced an equation to give predicted oocyte count if AMH and age are known. (Oocytes = age × (-ß) + Serum AMH × α) (Constant ß=0.0102 and α = 1.0407).
  
  
  CONCLUSIONS
  Combined use of serum AMH and age to predict ovarian response within reduced responder group should be further evaluated. For first time, we suggested combining both factors to predict ovarian response using a simple equation which allow developing tailored strategy.
authors.affiliation: Department Obstetrics and Gynaecology, University Hospitals of Leicester, Leicester, UK.
authors.forename: Yadava Bapurao
authors.initials: YB
authors.lastname: Jeve
keywords: Ovarian hyperstimulation; poor responders; serum antimullerian hormone