title: BMP2 shows neurotrophic effects including neuroprotection against neurodegeneration.
abstract: In this study, we found that BMP2 exerts neurotrophic effects, including a neuroprotective effect against nocodazole-induced neuritic degeneration, on neuronal cells. We also found that BMP2-induced neurotrophic effects are directly involved in Smad-dependent signaling as well as PI3K/PTEN-Akt-mTOR signaling. Moreover, BMP2-induced neurotrophic effects occur by stabilization of neuronal microtubules. Thus, these findings suggest that BMP2 can be a potential therapeutic target for nerve injury treatment.
authors.affiliation: aTissueGene Inc., Rockville, Maryland, USA bDepartment of Orthopedic Surgery, Gil Medical Center, Gachon University, Incheon cDepartment of Orthopedics, The Uniformed Force Capital Hospital, Kyunggido, Republic of Korea.
authors.forename: Aybike
authors.initials: A
authors.lastname: Saglam
authors.forename: Sukbum
authors.initials: S
authors.lastname: Kim
authors.forename: Kwangwook
authors.initials: K
authors.lastname: Ahn
authors.forename: Insuk
authors.initials: I
authors.lastname: Oh
authors.forename: Kwan-Hee
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000502:physiology; D055396:Bone Morphogenetic Protein 2 / Q000494:pharmacology*; D001921:Brain / Q000166:cytology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D018920:Coculture Techniques; D004791:Enzyme Inhibitors / Q000494:pharmacology; D051379:Mice; D009410:Nerve Degeneration / Q000517:prevention & control*; D016501:Neurites / Q000187:drug effects; D009447:Neuroblastoma / Q000473:pathology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016716:PC12 Cells; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects; D014404:Tubulin / Q000378:metabolism
chemical_list: C525720:Bmp2 protein, rat; D055396:Bone Morphogenetic Protein 2; D004791:Enzyme Inhibitors; D018696:Neuroprotective Agents; D014404:Tubulin