title: Efficacy of a New Topical Nano-hyaluronic Acid in Humans.
abstract: BACKGROUND
  The aim of this study was to evaluate the efficacy of a new topical low molecular nano-hyaluronic acid preparation in treating wrinkles, skin hydration, and skin elasticity in humans.
  
  
  METHODS
  Thirty-three women with an average age of 45.2 were studied for a period of eight weeks to measure the anti-wrinkle efficacy of a new nano-hyaluronic acid. The measurements were performed in the periorbital regions by investigating the three-dimensional structure using a DermaTOP for wrinkles, Corneometer for skin hydration, Cutometer for skin elasticity, and a Chroma Meter for erythema. Thereafter, standardized images were taken and evaluated by six selected and trained raters at the end of the study for reduction of visible wrinkles as well as skin color uniformity and pigmentation.
  
  
  RESULTS
  The results of the study showed a statistically significant moisturizing effect of the product range (lotion, serum, and cream, after 2,4, and 8 weeks of treatment. Measurement of skin roughness showed a significantly finer skin structure after two weeks of treatment, and skin elasticity showed a significant improvement after 2 and 8 weeks of treatment.
  
  
  CONCLUSIONS
  The new nano-hyaluronic acid clearly demonstrated a significant benefit in decreasing the depth of wrinkles (up to 40%), and skin hydration (up to 96%) and skin firmness and elasticity were significantly enhanced (up to 55%) at the end of eight weeks.
authors.affiliation: President, Miami Skin Institute; Associate Clinical Professor of Dermatology, University of Miami, Miller School of Medicine.
authors.forename: S Manjula
authors.initials: SM
authors.lastname: Jegasothy
authors.affiliation: Dermatologist, Aesthetic Medicine Institute, St. Petersburg, Russia.
authors.forename: Valentina
authors.initials: V
authors.lastname: Zabolotniaia
authors.affiliation: Stephan Bielfeldt CTO and Director Research proDERM Institute for Dermatological Research, Hamburg, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Bielfeldt