title: Pediatric subcutaneous panniculitis-like T-cell lymphoma with favorable result by immunosuppressive therapy: a report of two cases.
abstract: Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a rare type of skin lymphoma. Histopathology mimicking a lobular panniculitis makes it difficult to distinguish SPTL from benign autoimmune disease. We present cases of a 10-year-old female and an 11-year-old male with SPTL showing recurrent panniculitis and systemic manifestations. Initially, antibiotics and steroids were administered to treat infectious disease and benign panniculitis. However, they experienced recurrent fever and erythema nodosum. Additional immunohistochemistry and T-cell receptor (TCR) gene rearrangement analyses were performed, enabling the establishment of an SPTL diagnosis. The affected patients were given immunosuppressive therapy with favorable results.
authors.affiliation: Department of Hematology and Oncology, Shikoku Medical Center for Children and Adults , Kagawa , Japan.
authors.forename: Kozo
authors.initials: K
authors.lastname: Nagai
authors.forename: Naoko
authors.initials: N
authors.lastname: Nakano
authors.forename: Tsuyako
authors.initials: T
authors.lastname: Iwai
authors.forename: Asayuki
authors.initials: A
authors.lastname: Iwai
authors.forename: Hisamichi
authors.initials: H
authors.lastname: Tauchi
authors.forename: Kouichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ishii
mesh_terms: D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000188:drug therapy* / Q000276:immunology / Q000601:surgery; D008297:Male; D015434:Panniculitis / Q000175:diagnosis* / Q000188:drug therapy* / Q000276:immunology / Q000601:surgery; D012307:Risk Factors
chemical_list: D007166:Immunosuppressive Agents
keywords: T-cell receptor gene (TCR) rearrangement; immunosuppressive therapy; subcutaneous panniculitis-like T-cell lymphoma (SPTL)