title: Microstructure of subretinal drusenoid deposits revealed by adaptive optics imaging.
abstract: Subretinal drusenoid deposits (SDD), a recently recognized lesion associated with progression of age-related macular degeneration, were imaged with adaptive optics scanning laser ophthalmoscopy (AO-SLO) and optical coherence tomography (AO-OCT). AO-SLO revealed a distinct en face structure of stage 3 SDD, showing a hyporeflective annulus surrounded reflective core packed with hyperreflective dots bearing a superficial similarity to the photoreceptors in the unaffected retina. However, AO-OCT suggested that the speckled appearance over the SDD rendered by AO-SLO was the lesion material itself, rather than photoreceptors. AO-OCT assists proper interpretation and understanding of the SDD structure and the lesions' impact on surrounding photoreceptors produced by AO-SLO and vice versa.
authors.affiliation: Department of Ophthalmology, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, Al 35294, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Meadway
authors.affiliation: Department of Ophthalmology, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, Al 35294, USA.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, Al 35294, USA.
authors.forename: Christine A
authors.initials: CA
authors.lastname: Curcio
authors.affiliation: Department of Ophthalmology, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, Al 35294, USA ; Department of Vision Sciences, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294, USA ; Department of Biomedical Engineering, University of Alabama at Birmingham, 1825 University Boulevard, Birmingham, AL 35294, USA.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Zhang
keywords: (110.1080) Active or adaptive optics; (110.4500) Optical coherence tomography; (330.5310) Vision - photoreceptors; (330.7329) Visual optics, pathology