title: Progression of 'OMICS' methodologies for understanding the pathogenicity of Corynebacterium pseudotuberculosis: the Brazilian experience.
abstract: Since the first successful attempt at sequencing the Corynebacterium pseudotuberculosis genome, large amounts of genomic, transcriptomic and proteomic data have been generated. C. pseudotuberculosis is an interesting bacterium due to its great zoonotic potential and because it causes considerable economic losses worldwide. Furthermore, different strains of C. pseudotuberculosis are capable of causing various diseases in different hosts. Currently, we seek information about the phylogenetic relationships between different strains of C. pseudotuberculosis isolates from different hosts across the world and to employ these data to develop tools to diagnose and eradicate the diseases these strains cause. In this review, we present the latest findings on C. pseudotuberculosis that have been obtained with the most advanced techniques for sequencing and genomic organization. We also discuss the development of in silico tools for processing these data to prompt a better understanding of this pathogen.
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Fernanda A
authors.initials: FA
authors.lastname: Dorella
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Gala-Garcia
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Anne C
authors.initials: AC
authors.lastname: Pinto
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Boutros
authors.initials: B
authors.lastname: Sarrouh
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Camila A
authors.initials: CA
authors.lastname: Antunes
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Dayana
authors.initials: D
authors.lastname: Ribeiro
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Flavia F
authors.initials: FF
authors.lastname: Aburjaile
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Karina K
authors.initials: KK
authors.lastname: Fiaux
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Luis C
authors.initials: LC
authors.lastname: Guimarães
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Núbia
authors.initials: N
authors.lastname: Seyffert
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Rachid A
authors.initials: RA
authors.lastname: El-Aouar
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Renata
authors.initials: R
authors.lastname: Silva
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Syed S
authors.initials: SS
authors.lastname: Hassan
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Thiago L P
authors.initials: TL
authors.lastname: Castro
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Wanderson S
authors.initials: WS
authors.lastname: Marques
authors.affiliation: Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém-PA, Brazil.
authors.forename: Rommel
authors.initials: R
authors.lastname: Ramos
authors.affiliation: Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém-PA, Brazil.
authors.forename: Adriana
authors.initials: A
authors.lastname: Carneiro
authors.affiliation: Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém-PA, Brazil.
authors.forename: Pablo
authors.initials: P
authors.lastname: de Sá
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Anderson
authors.initials: A
authors.lastname: Miyoshi
authors.affiliation: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Vasco
authors.initials: V
authors.lastname: Azevedo
authors.affiliation: Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém-PA, Brazil.
authors.forename: Artur
authors.initials: A
authors.lastname: Silva
keywords: Corynebacterium pseudotuberculosis; Ion Torrent next generation sequencing; RNA-seq; SDS-PAGE; SOLiD next generation sequencing; mass spectrometry