title: [Clinical efficacy of tissue adhesive on intractable bleeding during endoscopic submucosal dissection].
abstract: OBJECTIVE
  To investigate the efficacy of tissue adhesive on intractable bleeding during endoscopic submucosal dissection(ESD) and delayed bleeding.
  
  
  METHODS
  A total of 9874 patients with gastrointestinal mucosal or submucosal tumors underwent ESD in our center from September 2006 to August 2013 and intractable bleeding occurred during ESD in 5 cases. Under the condition of no effective hemostasis methods, the tissue adhesive injection or spray were used to stop the bleeding. The efficacy and safety were evaluated.
  
  
  RESULTS
  All the 5 cases were successfully managed by the hemostasis method with tissue adhesive without any adverse event. In follow-up of two months after operation, wound healing and scar formation were observed under endoscopy.
  
  
  CONCLUSIONS
  Tissue adhesive is safe, effective and fast for intractable bleeding during ESD and delayed bleeding.
authors.affiliation: Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China. chen.shiyao@zs-hospital.sh.cn.
authors.forename: Lili
authors.initials: L
authors.lastname: Ma
authors.forename: Jingjing
authors.initials: J
authors.lastname: Lian
authors.forename: Pinghong
authors.initials: P
authors.lastname: Zhou
authors.forename: Meidong
authors.initials: M
authors.lastname: Xu
authors.forename: Liqing
authors.initials: L
authors.lastname: Yao
authors.forename: Shiyao
authors.initials: S
authors.lastname: Chen
mesh_terms: D004210:Dissection; D016099:Endoscopy, Gastrointestinal; D005753:Gastric Mucosa / Q000601:surgery*; D006470:Hemorrhage / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007413:Intestinal Mucosa / Q000601:surgery*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D014014:Tissue Adhesives