title: Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.
abstract: Efficacy of afoxolaner, a novel isoxazoline insecticide/acaricide, against Ixodes scapularis was evaluated in a laboratory study. One day prior to treatment, beagle dogs (n=16) were infested with 50 unfed wild adult ticks. Repeat infestations were performed weekly for four additional weeks. The number of live ticks remaining on each dog was determined 48 h after treatment and after each subsequent infestation. A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30.
authors.affiliation: Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096, USA. Electronic address: Elizabeth.Mitchell@Merial.com.
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Mitchell
authors.affiliation: TRS Labs, Inc., PO Box 5112, Athens, GA, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: McCall
authors.affiliation: Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096, USA.
authors.forename: S
authors.initials: S
authors.lastname: Theodore Chester
authors.affiliation: Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Larsen
mesh_terms: D056810:Acaricides / Q000008:administration & dosage*; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000517:prevention & control; D004285:Dogs; D005260:Female; D007555:Isoxazoles / Q000008:administration & dosage*; D018884:Ixodes; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage*; D059208:Parasite Load; D011897:Random Allocation; D013984:Tick Infestations / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D056810:Acaricides; D007555:Isoxazoles; D009281:Naphthalenes; C000589002:afoxolaner
keywords: Afoxolaner; Dogs; Ixodes scapularis; Oral; Ticks