title: [Advances in hypoxia microenvironment and chemotherapy-resistant of lung cancer].
abstract: Lung cancer is one of the malignant tumors with highest incidence recently in our country. Tumor hypoxia phenomenon was first discovered in lung cancer. It plays important roles in tumor cell drug-resistance, apoptosis, invasion and metastasis, angiogenesis. Chemotherapy-resistant is one of the core reasons of treatment failure and disease progress, and many works on the study of chemotherapy-resistant have been done. This article reviewed the research progress of those mechanisms by which lung cancer hypoxia microenvironment could induce chemotherapy-resistance.
authors.affiliation: Qinghai University, Xining 810001, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Oncology, Affilitated Hospital of Qinghai University, Xining 810001, China.
authors.forename: Milu
authors.initials: M
authors.lastname: Wu
authors.affiliation: Department of Oncology, Affilitated Hospital of Qinghai University, Xining 810001, China.
authors.forename: Junhui
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Oncology, Affilitated Hospital of Qinghai University, Xining 810001, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy / Q000378:metabolism*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000503:physiopathology; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents