title: A review of the solitary cutaneous T-cell lymphomas.
abstract: Cutaneous T-cell lymphomas (CTCL) account for almost 65-92% of all cutaneous lymphomas, many of which usually present with multiple lesions. However, a number of well-recognized and rare types of CTCL, including mycosis fungoides, can present in isolated fashion. These solitary lesions often run a relatively indolent clinical course but often pose diagnostic difficulties. We review histopathologically challenging solitary cutaneous T-cell lymphomas, including criteria for diagnosis, clinical course and prognosis, particularly for primary cutaneous CD4+ small/medium pleomorphic lymphoma and indolent CD8+ lymphoid proliferation of acral sites. In addition, we suggest an algorithm and nomenclature to aid in the diagnosis of such problematic lesions.
authors.affiliation: Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, USA.
authors.forename: Mina S
authors.initials: MS
authors.lastname: Ally
authors.forename: Alistair
authors.initials: A
authors.lastname: Robson
mesh_terms: D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology*; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology*
keywords: indolent CD8+ lymphoid proliferation of acral sites; pagetoid reticulosis; primary cutaneous CD4+ small/medium pleomorphic lymphoma; solitary mycosis fungoides