title: Asthma incidence and risk factors in a national longitudinal sample of adolescent Canadians: a prospective cohort study.
abstract: BACKGROUND
  Estimates of asthma incidence and its possible determinants in adolescent populations have rarely been obtained using prospective designs. We sought to identify socio-demographic and other patterns in the incidence of asthma among Canadian adolescents and to examine possible behavioural and environmental determinants of asthma incidence using longitudinal analyses.
  
  
  METHODS
  We used data from the National Population Health Survey (NPHS), a nationally representative longitudinal survey of Canadians. All persons aged 12-18 years without asthma at baseline were followed up to a maximum of 12 years. The outcome was a reported diagnosis of asthma during the follow-up period. Analyses were weighted to the population and bootstrapping procedures were used to estimate variances.
  
  
  RESULTS
  Participants (n = 956) represented 2,038,890 adolescents of whom 293,450 (14.4%) developed asthma over the 21,274,890 person-years of follow-up. Overall, the incidence of asthma was 10.2 per 1000 person-years. In adjusted Cox regression analysis, being female (HR = 2.13, 95% CI = 1.26-3.62, p = 0.005) and being exposed to passive smoking (HR = 2.06, 95% CI = 1.27-3.34, p = 0.003) were associated with the development of asthma while no statistically significant associations were identified for rural residence, being overweight, and other health behaviours. There was also an apparent cohort effect among girls where girls who were older at baseline reported being diagnosed with asthma more over the follow-up than their younger counterparts. This was not observed among males.
  
  
  CONCLUSIONS
  Asthma prevention initiatives for adolescents should target girls and focus on smoking exposures. The role that differential diagnostic patterns play in these observations should be investigated to more accurately assess the incidence of asthma.
authors.affiliation: Canadian Centre for Health and Safety in Agriculture, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada. josh.lawson@usask.ca.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Lawson
authors.forename: Ian
authors.initials: I
authors.lastname: Janssen
authors.forename: Mark W
authors.initials: MW
authors.lastname: Bruner
authors.forename: Alomgir
authors.initials: A
authors.lastname: Hossain
authors.forename: William
authors.initials: W
authors.lastname: Pickett
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000453:epidemiology*; D002170:Canada / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors