title: Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo.
abstract: OBJECTIVE
  The aim of the presented article was investigation of anticancer efficacy of hydroxyethylthiamine diphosphate (HTD) in vivo.
  
  
  METHODS
  The study was carried out on 30 C57BL/6J mice subcutaneously transplanted with Ehrlich carcinoma. Animals were treated with intraperitoneal injections of the solution composed from pyruvic acid and thiamine bromide every other day during 10 days and thereafter, every day during 2 weeks. Treatment efficacy was evaluated by tumor growth inhibition.
  
  
  RESULTS
  In experimental animals treated with HTD, significant tumor growth inhibition has been registered: 73% at day 45(th) compared to the control group (p < 0.001).
  
  
  CONCLUSIONS
  Treatment with HTD demonstrated high anticancer efficacy in vivo.
authors.affiliation: Oncology National Center, Tbilisi, Georgia.
authors.forename: L
authors.initials: L
authors.lastname: Gevorkyan
authors.affiliation: Pathophysiology Department, Tbilisi State Medical University, Tbilisi, Georgia.
authors.forename: K
authors.initials: K
authors.lastname: Gambashidze
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D007274:Injections, Intraperitoneal; D051379:Mice; D010119:Oxythiamine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D010119:Oxythiamine; C008030:hydroxyethylthiamine