title: Short-term insulin requirements following gastric bypass surgery in severely obese women with type 1 diabetes.
abstract: BACKGROUND
  In severely obese type 2 diabetes patients, gastric bypass surgery (GB) reduces body mass index (BMI) and hemoglobin A1c (HbA1c) and allows reduced doses of insulin and other medications. Data regarding the effects of GB on severely obese patients with type 1 diabetes are limited.
  
  
  METHODS
  Severely obese women with type 1 diabetes (n = 9) were studied immediately before and after GB (7.7 ± 5.8 weeks, mean ± SD).
  
  
  RESULTS
  On average, GB reduced mean BMI by 11% and mean HbA1c by 0.9% (from 8.0 to 7.1%), with a parallel 38% decrease in basal insulin requirements (expressed per kilogram of body weight).
  
  
  CONCLUSIONS
  GB rapidly decreased BMI, HbA1c, and insulin requirements in severely obese women with type 1 diabetes. However, physiologic insulin replacement remains necessary in patients with type 1 diabetes.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, USA, rmiddelb@bidmc.harvard.edu.
authors.forename: Roeland J W
authors.initials: RJ
authors.lastname: Middelbeek
authors.forename: Tamarra
authors.initials: T
authors.lastname: James-Todd
authors.forename: Mary-Elizabeth
authors.initials: ME
authors.lastname: Patti
authors.forename: Florence M
authors.initials: FM
authors.lastname: Brown
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005260:Female; D015390:Gastric Bypass; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000150:complications / Q000601:surgery*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin