title: PONV in Ambulatory surgery: A comparison between Ramosetron and Ondansetron: a prospective, double-blinded, and randomized controlled study.
abstract: BACKGROUND
  postoperative nausea and vomiting (PONV) frequently hampers implementation of ambulatory surgery in spite of so many antiemetic drugs and regimens.
  
  
  OBJECTIVE
  the study was carried out to compare the efficacy of Ramosetron and Ondansetron in preventing PONV after ambulatory surgery.
  
  
  METHODS
  it was a prospective, double blinded, and randomized controlled study.
  
  
  METHODS
  124 adult patients of either sex, aged 25-55, of ASA physical status I and II, scheduled for day care surgery, were randomly allocated into Group A [(n=62) receiving (IV) Ondansetron (4 mg)] and Group B [(n=62) receiving IV Ramosetron (0.3 mg)] prior to the induction of general anesthesia in a double-blind manner. Episodes of PONV were noted at 0.5, 1, 2, 4 h, 6, 12, and 18 h postoperatively.
  
  
  RESULTS
  statistically significant difference between Groups A and B (P <0.05) was found showing that Ramosetron was superior to Ondansetron as antiemetic both regarding frequency and severity.
  
  
  CONCLUSIONS
  it was evident that preoperative prophylactic administration of single dose IV Ramosetron (0.3 mg) has better efficacy than single dose IV Ondansetron (4 mg) in reducing the episodes of PONV over 18 h postoperatively in patients undergoing day-care surgery under general anesthesia.
authors.affiliation: Department of Anaesthesiology, MNC and H, Berhampur, West Bengal, India.
authors.forename: Debasis
authors.initials: D
authors.lastname: Banerjee
authors.affiliation: C.M.S.D.H, Kolkata, West Bengal, India.
authors.forename: Anjan
authors.initials: A
authors.lastname: Das
authors.affiliation: NRS Medical College, Kolkata, West Bengal, India.
authors.forename: Saikat
authors.initials: S
authors.lastname: Majumdar
authors.affiliation: Department of G and O, Burdwan Medical College, Burdwan, West Bengal, India.
authors.forename: Rahul Deb
authors.initials: RD
authors.lastname: Mandal
authors.affiliation: Department of Orthopedics, R.G. Kar Medical College, Kolkata, West Bengal, India.
authors.forename: Soumyadip
authors.initials: S
authors.lastname: Dutta
authors.affiliation: NRS Medical College, Kolkata, West Bengal, India.
authors.forename: Anindya
authors.initials: A
authors.lastname: Mukherjee
authors.affiliation: C.M.S.D.H, Kolkata, West Bengal, India.
authors.forename: Aparna
authors.initials: A
authors.lastname: Chakraborty
authors.affiliation: C.M.S.D.H, Kolkata, West Bengal, India.
authors.forename: Sandip
authors.initials: S
authors.lastname: Chattopadhyay
keywords: Ambulatory (day care) surgery; American Society of Anaesthesiologists; Ondansetron; Ramosetron; postoperative nausea and vomiting; visual analogue score