title: Yanshu spraying agent, a traditional Chinese medicine, relieves chronic pharyngitis in animals by anti-inflammatory and antibacterial effects.
abstract: Chronic pharyngitis is chronic inflammation that is often caused by repeated occurrences of acute pharyngitis or upper respiratory tract infections, includingStreptococcusandStaphylococcus. The present study aimed to investigate the effects of Yanshu spraying agent (Yanshu) in relieving chronic pharyngitis, as well as the possible underlying mechanisms. The results revealed that Yanshu inhibited chronic inflammation in ammonia-induced chronic pharyngitis in rabbits and cotton pellet-induced granuloma tissue formation in rats. Yanshu also demonstrated antibacterial effects onStreptococcusandStaphylococcus in vitro. Yanshu did not exhibit any effects on the immune system, including the spleen and thymus indexes, immunocyte count and monocyte-macrophage function, when compared with the effects of dexamethasone. Therefore, the results of the present study indicate that Yanshu may relieve chronic pharyngitis via its anti-inflammatory and antibacterial activities.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China.
authors.forename: Chengwen
authors.initials: C
authors.lastname: Lu
authors.affiliation: Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China.
authors.forename: Yanqin
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China.
authors.forename: Jianqiao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: DU
authors.affiliation: Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China.
authors.forename: Tian
authors.initials: T
authors.lastname: Wang
authors.affiliation: Shandong Luye Pharmaceutical Company, Ltd., Yantai, Shandong 264003, P.R. China.
authors.forename: Yunli
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China.
authors.forename: Fenghua
authors.initials: F
authors.lastname: Fu
authors.affiliation: Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China.
authors.forename: Leiming
authors.initials: L
authors.lastname: Zhang
keywords: Yanshu spraying agent; anti-inflammatory effects; antibacterial effects; chronic pharyngitis