title: Face-to-face with anti-inflammatory therapy for rosacea.
abstract: In the past, our understanding of rosacea has been inadequate and limited to descriptions of factors that exacerbate and improve the disease. While the pathophysiology of rosacea is complex and multifactorial, cathelicidin peptides have emerged as key players in the pathogenesis of this common dermatological disorder. This article correlates recent findings in abnormal cathelicidin production and proteolytic processing in rosacea with therapeutic actions of current treatment options and, in this way, highlights potential points of intervention for the development of efficient therapeutic alternatives.
authors.affiliation: Department of Dermatology and Allergy, Ludwig-Maximilian-University, Munich, Germany.
authors.forename: Suzanna
authors.initials: S
authors.lastname: Salzer
authors.forename: Thomas
authors.initials: T
authors.lastname: Ruzicka
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schauber
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D012393:Rosacea / Q000188:drug therapy* / Q000503:physiopathology; D054804:Cathelicidins
chemical_list: D000893:Anti-Inflammatory Agents; D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins
keywords: cathelicidin; doxycycline; innate immunity; protease activity; rosacea