title: Influence of non-steroidal anti-inflammatory drugs (NSAIDs) on osseointegration of dental implants in rabbit calvaria.
abstract: OBJECTIVE
  Until recently, adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs) on osseointegration of dental implants were unknown. Hence, this study investigated the short- and long-term effects of a 7-day regimen of parecoxib and diclofenac sodium on osseointegration of dental implants in calvarial bone.
  
  
  METHODS
  Eighteen New Zealand White rabbits were randomly allocated into three groups (each n = 6): Control group with no postoperative pain killers (Group A), diclofenac group (Group B) and parecoxib group (Group C). In each animal, one dental implant was placed into the calvarial bone (total n = 18). Three rabbits from each group were sacrificed in Week 4. The other three rabbits from each group were sacrificed in Week 12 postoperatively. The implant together with the calvarial bone and dura mater was harvested and subjected to micro-computed tomography (micro-CT) and histomorphometric analysis.
  
  
  RESULTS
  Quantitative analysis of micro-CT data and histomorphometric data neither revealed any statistically significant (P ≤ 0.05) differences between the three different groups related to osseointegration nor between different time points of observation.
  
  
  CONCLUSIONS
  In rabbits, a 7-day regimen of appropriate doses of diclofenac sodium and parecoxib did not adversely affect osseointegration of dental implants and bone healing in calvaria, neither short nor long term (12 weeks).
authors.affiliation: Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
authors.forename: Wei Xin
authors.initials: WX
authors.lastname: Cai
authors.affiliation: Discipline of Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.affiliation: Discipline of Oral Diagnosis and Polyclinics, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
authors.forename: Li Wu
authors.initials: LW
authors.lastname: Zheng
authors.affiliation: Division of Craniomaxillofacial and Oral Surgery, University Hospital, University of Zurich, Zurich, Switzerland.
authors.forename: Astrid
authors.initials: A
authors.lastname: Kruse-Gujer
authors.affiliation: Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Zurich, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Stübinger
authors.affiliation: The University of Hong Kong, Prince Philip Dental Hospital, Hong Kong, China.|University of Zurich, Zurich, Switzerland.
authors.forename: Niklaus P
authors.initials: NP
authors.lastname: Lang
authors.affiliation: Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
authors.forename: Roger A
authors.initials: RA
authors.lastname: Zwahlen
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D015921:Dental Implants; D004008:Diclofenac / Q000494:pharmacology*; D020007:Implants, Experimental; D007555:Isoxazoles / Q000494:pharmacology*; D016348:Osseointegration / Q000187:drug effects*; D011817:Rabbits; D012886:Skull / Q000000981:diagnostic imaging / Q000601:surgery*; D055114:X-Ray Microtomography
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015921:Dental Implants; D007555:Isoxazoles; D004008:Diclofenac; C409945:parecoxib
keywords: dental implant; diclofenac; non-steroidal anti-inflammatory drugs; osseointegration; parecoxib