title: Synthesis of enantiomerically enriched triarylmethanes by enantiospecific Suzuki-Miyaura cross-coupling reactions.
abstract: The Suzuki-Miyaura cross-coupling of chiral, enantiomerically enriched dibenzylic boronic esters is described. The reaction proceeds with almost complete retention of stereochemistry, providing access to triarylmethanes, compounds that have high biological activity and are difficult to prepare in enantiomerically pure form using other methods.
authors.affiliation: Department of Chemistry, Queen's University , 90 Bader Lane, Kingston, Ontario K7L 3N6, Canada.
authors.forename: Smitha C
authors.initials: SC
authors.lastname: Matthew
authors.forename: Ben W
authors.initials: BW
authors.lastname: Glasspoole
authors.forename: Patrick
authors.initials: P
authors.lastname: Eisenberger
authors.forename: Cathleen M
authors.initials: CM
authors.lastname: Crudden
mesh_terms: D001554:Benzene / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D008697:Methane / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D001554:Benzene; D008697:Methane