title: Percutaneous closure of postinfarct muscular ventricular septal defects: a multicenter study in China.
abstract: BACKGROUND
  Surgical repair is an effective method to treat ventricular septal defect (VSD) complicating acute myocardial infarction (AMI). However, the mortality rate remains high. This study was designed to assess the immediate and mid-term results of transcatheter closure of postinfarct muscular VSDs.
  
  
  METHODS
  Data were retrospectively collected from 42 AMI patients who underwent attempted transcatheter VSD closure between 2008 and 2012 in seven heart centers of China.
  
  
  RESULTS
  Nine patients underwent emergent VSD closure in the acute phase (within two weeks from VSD) while the others underwent elective closure. The time between VSD occurrence and closure in emergency group and elective group was 7.7 ± 2.3 days and 35 ± 14.5 days, respectively (p<0.01). The percentage of procedure success in the emergency group and elective group was 77.8% (7/9) and 97% (32/33), respectively (p=0.048). The hospital mortality was higher for emergent closure in comparison to elective closure (66.7% vs. 6.1%, p<0.01). During a median follow-up of 25 months (0-58 months), two patients died at 8 and 29 months, respectively, and no serious complications occurred in other patients.
  
  
  CONCLUSIONS
  Interventional postinfarct VSD closure is a safe and effective approach that can be performed with a high procedural success rate, with favorable outcomes if it can be undertaken >14 days postinfarct.
authors.affiliation: Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China.
authors.forename: Su-Xuan
authors.initials: SX
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Henan Provincial Chest Hospital, Zhengzhou 450008, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou 450003, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, PR China.
authors.forename: Bai-Ming
authors.initials: BM
authors.lastname: Qu
authors.affiliation: Department of Cardiology, Fujian Provincial Hospital, Fuzhou 350001, PR China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Shanghai East Hospital, Shanghai 200120, PR China.
authors.forename: Dai-Fu
authors.initials: DF
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China. Electronic address: xianxianz2010@163.com.
authors.forename: Xian-Xian
authors.initials: XX
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China. Electronic address: qywsmmu@163.com.
authors.forename: Yong-Wen
authors.initials: YW
authors.lastname: Qin
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization; D002681:China; D017558:Elective Surgical Procedures; D004630:Emergencies; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications* / Q000401:mortality / Q000628:therapy*; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D012189:Retrospective Studies; D055989:Septal Occluder Device; D061665:Time-to-Treatment
keywords: Congenital heart disease; Postinfarct; Transcatheter; Ventricular septal defect