title: Uniform iron oxide hollow spheres for high-performance delivery of insoluble anticancer drugs.
abstract: As an intrinsic characteristic of many anticancer drugs, low solubility in physiological conditions limits the usage of these active ingredients in clinics. To overcome this bottleneck, we attempt to design and construct a high-performance magnetic-targeted delivery system based on uniform iron oxide hollow spheres. Via a facile one-pot solvothermal route, well-defined iron oxide hollow spheres were prepared with inexpensive inhesion. Compared with previously reported mesoporous Fe3O4 nanoparticles, our iron oxide hollow spheres have a larger void space giving the structures a higher storage capacity for guest molecules. In our present work, camptothecin (CPT) was selected as a model insoluble anticancer drug to confirm the efficiency of drug-loading and chemotherapy in vitro. Detailed anticancer efficacy was further investigated by using MTT assays and microscope imaging methods, indicating that these iron oxide hollow spheres are promising for insoluble drug delivery.
authors.affiliation: Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100069, P. R. China. tianyebfh@gmail.com.
authors.forename: Yichen
authors.initials: Y
authors.lastname: Zhu
authors.forename: Jie
authors.initials: J
authors.lastname: Lei
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity; D002166:Camptothecin / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry; D051379:Mice; D041681:NIH 3T3 Cells
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D052203:Ferrosoferric Oxide; D002166:Camptothecin