title: Statistical methods for the analysis of high-throughput metabolomics data.
abstract: Metabolomics is a relatively new high-throughput technology that aims at measuring all endogenous metabolites within a biological sample in an unbiased fashion. The resulting metabolic profiles may be regarded as functional signatures of the physiological state, and have been shown to comprise effects of genetic regulation as well as environmental factors. This potential to connect genotypic to phenotypic information promises new insights and biomarkers for different research fields, including biomedical and pharmaceutical research. In the statistical analysis of metabolomics data, many techniques from other omics fields can be reused. However recently, a number of tools specific for metabolomics data have been developed as well. The focus of this mini review will be on recent advancements in the analysis of metabolomics data especially by utilizing Gaussian graphical models and independent component analysis.
authors.affiliation: Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Bartel
authors.affiliation: Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Krumsiek
authors.affiliation: Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany ; Department of Mathematics, Technische Universität München, Boltzmannstr. 3, 85747 Garching, Germany.
authors.forename: Fabian J
authors.initials: FJ
authors.lastname: Theis