title: An assessment of wound healing potential of Argyreia speciosa leaves.
abstract: In North India, poultice of young unfolded leaves of Argyreia speciosa Linn. (Convolvulaceae) is used for healing wounds. In order to find scientific evidence for the traditional utilization of leaves of A. speciosa in wound healing, this investigation was carried out. A linear incision wound of about 3 cm in length and 2 mm in depth and circular excision wound of 177 mm(2) full thickness were made on the dorsal region of separate groups (n = 5) of anesthetized Swiss albino mice. A simple ointment, developed by including ethanol, ethanol-water, and water extracts (10% each, separately) of A. speciosa, was applied topically to mice once daily for 14 days after wounding. To evaluate the effect of each extract, wound contraction, epithelization period, wound breaking strength, and hydroxyproline content were determined. The water extract of A. speciosa showed accelerated wound healing activity as evidenced by fast wound contraction (96.30 ± 0.52%; P < 0.01), rapid epithelization period (11.40 ± 0.60 days; P < 0.001), greater wound breaking strength (376.56 ± 21.16 g; P < 0.001), and higher hydroxyproline content (16.49 ± 1.12 mg/g; P < 0.05) of granulation tissue. The present report supports the traditional use of Argyreia speciosa leaves for wound healing and signify its relevant therapeutic potential.
authors.affiliation: Herbal Medicinal Products Department, CSIR-Central Institute of Medicinal and Aromatic Plants, (CIMAP), Lucknow 226 015, India.
authors.forename: Kuldeep Singh
authors.identifier: 0000-0003-1185-5162
authors.initials: KS
authors.lastname: Yadav
authors.affiliation: Herbal Medicinal Products Department, CSIR-Central Institute of Medicinal and Aromatic Plants, (CIMAP), Lucknow 226 015, India.
authors.forename: Narayan Prasad
authors.initials: NP
authors.lastname: Yadav
authors.affiliation: Herbal Medicinal Products Department, CSIR-Central Institute of Medicinal and Aromatic Plants, (CIMAP), Lucknow 226 015, India.
authors.forename: Bindu
authors.initials: B
authors.lastname: Rawat
authors.affiliation: Herbal Medicinal Products Department, CSIR-Central Institute of Medicinal and Aromatic Plants, (CIMAP), Lucknow 226 015, India.
authors.forename: Vineet Kumar
authors.initials: VK
authors.lastname: Rai
authors.affiliation: Analytical Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants, (CIMAP), Lucknow 226 015, India.
authors.forename: Karuna
authors.initials: K
authors.lastname: Shanker
authors.affiliation: Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Rana Pratap Marg, Lucknow 226 001, India.
authors.forename: Chandana
authors.initials: C
authors.lastname: Venkateswara Rao
mesh_terms: D000287:Administration, Topical; D000818:Animals; D027741:Ipomoea / Q000737:chemistry*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology*; D014950:Wounds, Penetrating / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology
chemical_list: D010936:Plant Extracts