title: Immunological memory within the innate immune system.
abstract: Immune memory has traditionally been the domain of the adaptive immune system, present only in antigen-specific T and B cells. The purpose of this review is to summarize the evidence for immunological memory in lower organisms (which are not thought to possess adaptive immunity) and within specific cell subsets of the innate immune system. A special focus will be given to recent findings in both mouse and humans for specificity and memory in natural killer (NK) cells, which have resided under the umbrella of innate immunity for decades. The surprising longevity and enhanced responses of previously primed NK cells will be discussed in the context of several immunization settings.
authors.affiliation: Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, New York, NY, USA sunj@mskcc.org.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Sun
authors.affiliation: Centre d'Immunologie de Marseille-Luminy UM2 Aix-Marseille Université, Marseille, France INSERM U1104, Marseille, France CNRS UMR7280, Marseille, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Ugolini
authors.affiliation: Centre d'Immunologie de Marseille-Luminy UM2 Aix-Marseille Université, Marseille, France INSERM U1104, Marseille, France CNRS UMR7280, Marseille, France Service d'Immunologie, Assistance Publique-Hôpitaux de Marseille Hôpital de la Conception, Marseille, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Vivier
mesh_terms: D000818:Animals; D005075:Biological Evolution; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology*; D007448:Invertebrates / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008959:Models, Neurological; D013045:Species Specificity
keywords: NK cells; immunity; innate immunity; memory