title: Prevalence of human Herpesviridae in cerebrospinal fluid of patients with multiple sclerosis and noninfectious neurological disease in the Netherlands.
abstract: Prevalence of eight human herpesviruses (HHV1-8) was determined by real-time PCR in cell-rich cerebrospinal fluid (CSF) samples, obtained early after disease symptoms, of Dutch patients with multiple sclerosis (MS) and other noninfectious central nervous system diseases (NIND). Whereas HHV1-8 DNA was undetectable in CSF samples of MS patients, HHV6 DNA was detected in a plexus neuritis case and HHV7 DNA in an ependymoma and a Behçets' disease patient. However, intrathecal HHV infection was not detected. Data indicate that HHV1-8 are rarely detected in CSF of Dutch NIND patients and do not support the role of intrathecal HHV infection early after onset of disease symptoms in MS.
authors.affiliation: Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Gijsbert P
authors.initials: GP
authors.lastname: van Nierop
authors.forename: Rogier Q
authors.initials: RQ
authors.lastname: Hintzen
authors.forename: Georges M G M
authors.initials: GM
authors.lastname: Verjans
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D005260:Female; D006564:Herpesviridae; D006566:Herpesviridae Infections / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000821:virology*; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000821:virology; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral