title: [Prokineticins: new regulatory peptides in human reproduction].
abstract: During the last decade, there has been growing evidence for the involvement of prokineticins and their receptors (PROK/PROKR) in human reproduction, with multiple roles in the female and male reproductive systems. The PROK/PROKR signalling complex has been reported as a new actor in ovary, uterus, placenta, and testis physiology, with marked dysfunction in various pathological conditions such as polycystic ovary syndrome, recurrent pregnancy loss, preeclampsia, and ectopic pregnancy. Altogether, the results strongly suggest the involvement of prokineticins in spermatogenesis, oocyte competence, embryo implantation, pregnancy, and delivery, and argue for the clinical relevance of these cytokines and their receptors as diagnostic markers for several reproductive diseases.
authors.affiliation: Centre hospitalier universitaire de Grenoble, hôpital couple-enfant, centre d'aide médicale à la procréation, CS 10217, 38043 Grenoble Cedex 9, France - Inserm U1036, biologie du cancer et de l'infection, iRTSV, CEA Grenoble, 17, rue des Martyrs, 38054 Grenoble Cedex 9, France - Commissariat à l'énergie atomique, institut de recherche en technologie et sciences pour le vivant, 38054 Grenoble Cedex 9, France - Université Grenoble-Alpes, 38041 Grenoble, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Brouillet
authors.affiliation: Centre hospitalier universitaire de Grenoble, hôpital couple-enfant, centre d'aide médicale à la procréation, CS 10217, 38043 Grenoble Cedex 9, France - Inserm U1036, biologie du cancer et de l'infection, iRTSV, CEA Grenoble, 17, rue des Martyrs, 38054 Grenoble Cedex 9, France - Commissariat à l'énergie atomique, institut de recherche en technologie et sciences pour le vivant, 38054 Grenoble Cedex 9, France - Université Grenoble-Alpes, 38041 Grenoble, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Hoffmann
authors.affiliation: Inserm U1036, biologie du cancer et de l'infection, iRTSV, CEA Grenoble, 17, rue des Martyrs, 38054 Grenoble Cedex 9, France - Commissariat à l'énergie atomique, institut de recherche en technologie et sciences pour le vivant, 38054 Grenoble Cedex 9, France - Université Grenoble-Alpes, 38041 Grenoble, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Alfaidy
authors.affiliation: Inserm U1036, biologie du cancer et de l'infection, iRTSV, CEA Grenoble, 17, rue des Martyrs, 38054 Grenoble Cedex 9, France - Commissariat à l'énergie atomique, institut de recherche en technologie et sciences pour le vivant, 38054 Grenoble Cedex 9, France - Université Grenoble-Alpes, 38041 Grenoble, France.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Feige
mesh_terms: D000818:Animals; D005260:Female; D005768:Gastrointestinal Hormones / Q000502:physiology*; D006801:Humans; D008297:Male; D009479:Neuropeptides / Q000302:isolation & purification / Q000502:physiology*; D011247:Pregnancy; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D012098:Reproduction / Q000502:physiology*; D012910:Snake Venoms / Q000737:chemistry; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / Q000502:physiology*
chemical_list: D005768:Gastrointestinal Hormones; D009479:Neuropeptides; C467610:PROK1 protein, human; C423608:PROK2 protein, human; C470837:PROKR1 protein, human; D043562:Receptors, G-Protein-Coupled; D012910:Snake Venoms; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived