title: Automatic detection of CT perfusion datasets unsuitable for analysis due to head movement of acute ischemic stroke patients.
abstract: Head movement during brain Computed Tomography Perfusion (CTP) can deteriorate perfusion analysis quality in acute ischemic stroke patients. We developed a method for automatic detection of CTP datasets with excessive head movement, based on 3D image-registration of CTP, with non-contrast CT providing transformation parameters. For parameter values exceeding predefined thresholds, the dataset was classified as 'severely moved'. Threshold values were determined by digital CTP phantom experiments. The automated selection was compared to manual screening by 2 experienced radiologists for 114 brain CTP datasets. Based on receiver operator characteristics, optimal thresholds were found of respectively 1.0°, 2.8° and 6.9° for pitch, roll and yaw, and 2.8 mm for z-axis translation. The proposed method had a sensitivity of 91.4% and a specificity of 82.3%. This method allows accurate automated detection of brain CTP datasets that are unsuitable for perfusion analysis.
authors.affiliation: Department of Biomedical Engineering and Physics, Academic Medical Centre, Amsterdam, the Netherlands Department of Electrical Engineering, University of Sumatra Utara, Indonesia.
authors.forename: Fahmi
authors.initials: F
authors.lastname: Fahmi
authors.affiliation: Department of Biomedical Engineering and Physics, Academic Medical Centre, Amsterdam, the Netherlands Department of Radiology, Academic Medical Centre, Amsterdam, the Netherlands.
authors.forename: Henk A
authors.initials: HA
authors.lastname: Marquering
authors.affiliation: Department of Biomedical Engineering and Physics, Academic Medical Centre, Amsterdam, the Netherlands Department of Radiology, Academic Medical Centre, Amsterdam, the Netherlands.
authors.forename: Geert J
authors.initials: GJ
authors.lastname: Streekstra
authors.affiliation: Department of Radiology, Academic Medical Centre, Amsterdam, the Netherlands.
authors.forename: Ludo F M
authors.initials: LF
authors.lastname: Beenen
authors.affiliation: Department of Biomedical Engineering and Physics, Academic Medical Centre, Amsterdam, the Netherlands.
authors.forename: Natasja N Y
authors.initials: NN
authors.lastname: Janssen
authors.affiliation: Department of Radiology, Academic Medical Centre, Amsterdam, the Netherlands.
authors.forename: Charles B L
authors.initials: CB
authors.lastname: Majoie
authors.affiliation: Department of Biomedical Engineering and Physics, Academic Medical Centre, Amsterdam, the Netherlands.
authors.forename: Ed
authors.initials: E
authors.lastname: van Bavel
mesh_terms: D001331:Automation; D001921:Brain / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000000981:diagnostic imaging; D019416:Head Movements; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D015588:Observer Variation; D010477:Perfusion; D019047:Phantoms, Imaging; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020521:Stroke / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
keywords: acute ischemic stroke; brain CT perfusion; computer aided detection; patient movement