title: Endo- and exocytic budding transformation of slow-diffusing membrane domains induced by Alzheimer's amyloid beta.
abstract: Cell-sized liposomes are a powerful tool for clarifying physicochemical mechanisms that govern molecular interactions. Herein, budding transformation of membrane domains was induced by amyloid beta peptides. The peptides increased the membrane viscosity as demonstrated by the Brownian motion of membrane domains. These results could aid in understanding the physicochemical mechanism of Alzheimer's disease.
authors.affiliation: School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1, Asahidai, Nomi City, Ishikawa 923-1292, Japan. t-hamada@jaist.ac.jp.
authors.forename: Masamune
authors.initials: M
authors.lastname: Morita
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hamada
authors.forename: Mun'delanji C
authors.initials: MC
authors.lastname: Vestergaard
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takagi
mesh_terms: D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D004058:Diffusion; D008081:Liposomes / Q000737:chemistry*; D021962:Membrane Microdomains; D010446:Peptide Fragments / Q000737:chemistry*; D014783:Viscosity
chemical_list: D016229:Amyloid beta-Peptides; D008081:Liposomes; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)