title: Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes.
abstract: Adults with type 1 diabetes have lower serum uric acid levels compared with nondiabetic adults. Little is known about the relationship between serum uric acid and blood pressure in type 1 diabetes and whether it differs from the positive relationship found in nondiabetic adults. The authors assessed the cross-sectional and longitudinal relationships over 6 years between serum uric acid and blood pressure in adults with (35±9 years [n=393]) and without (38±9 years [n=685]) type 1 diabetes in the Coronary Artery Calcification in Type 1 Diabetes study. In nondiabetic adults, serum uric acid was associated with systolic blood pressure in multivariable models adjusted for cardiovascular risk factors. In adults with type 1 diabetes, a negative association was observed between serum uric acid and systolic blood pressure after multivariable adjustments. A positive association was observed between serum uric acid and systolic blood pressure in nondiabetic adults. In contrast, an inverse relationship was demonstrated after multivariable adjustments in type 1 diabetes.
authors.affiliation: Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
authors.forename: Petter
authors.initials: P
authors.lastname: Bjornstad
authors.forename: R
authors.initials: R
authors.lastname: Paul Wadwa
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Sirota
authors.forename: Janet K
authors.initials: JK
authors.lastname: Snell-Bergeon
authors.forename: Kimberly
authors.initials: K
authors.lastname: McFann
authors.forename: Marian
authors.initials: M
authors.lastname: Rewers
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Rivard
authors.forename: Diana
authors.initials: D
authors.lastname: Jalal
authors.forename: Michel B
authors.initials: MB
authors.lastname: Chonchol
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Johnson
authors.forename: David M
authors.initials: DM
authors.lastname: Maahs
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015999:Multivariate Analysis; D012044:Regression Analysis; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid