title: Monte Carlo simulations of dose distributions with necrotic tumor targeted radioimmunotherapy.
abstract: Radio-resistant hypoxic tumor cells are significant contributors to the locoregional recurrences and distant metastases that mark failure of radiotherapy. Due to restricted tissue oxygenation, chronically hypoxic tumor cells frequently become necrotic and thus there is often an association between chronically hypoxic and necrotic tumor regions. This simulation study is the first in a series to determine the feasibility of hypoxic cell killing after first targeting adjacent areas of necrosis with either an α- or β-emitting radioimmunoconjugate.
authors.affiliation: Department of Medical Physics, Royal Adelaide Hospital, Adelaide, SA 5000, Australia; School of Chemistry and Physics, University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: scott.penfold@health.sa.gov.au.
authors.forename: Scott N
authors.initials: SN
authors.lastname: Penfold
authors.affiliation: Cancer Clinical Trials Unit, Royal Adelaide Hospital, Adelaide, SA 5000, Australia; School of Medicine, University of Adelaide, Adelaide, SA 5005, Australia; Translational Oncology Laboratory, Centre for Cancer Biology, SA Pathology, Adelaide, SA 5000, Australia.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Brown
authors.affiliation: Translational Oncology Laboratory, Centre for Cancer Biology, SA Pathology, Adelaide, SA 5000, Australia.
authors.forename: Alexander H
authors.initials: AH
authors.lastname: Staudacher
authors.affiliation: Department of Medical Physics, Royal Adelaide Hospital, Adelaide, SA 5000, Australia; School of Chemistry and Physics, University of Adelaide, Adelaide, SA 5005, Australia.
authors.forename: Eva
authors.initials: E
authors.lastname: Bezak
mesh_terms: D065638:Absorption, Radiation; D003198:Computer Simulation; D006801:Humans; D007856:Lead Radioisotopes / Q000627:therapeutic use*; D015233:Models, Statistical; D009010:Monte Carlo Method; D009336:Necrosis / Q000473:pathology / Q000532:radiotherapy; D009369:Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D016499:Radioimmunotherapy / Q000379:methods*; D011874:Radiometry / Q000379:methods*; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*
chemical_list: D007856:Lead Radioisotopes; D019275:Radiopharmaceuticals
keywords: Hypoxia; La antigen; Monte Carlo simulations; Radioimmunotherapy; Targeted alpha therapy