title: Differential adhesion drives angiogenesis.
abstract: New blood vessels sprout from existing vasculature to ensure vascularization of developing organs and tissues. A combination of computational modelling and experimental analysis shows that sprout elongation is mediated by differential adhesion dynamics among endothelial cells. The adhesiveness of an individual endothelial cell is governed by VEGF and Notch signalling.
authors.affiliation: 1] IFOM, FIRC institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy [2] Department of Biosciences, University of Milan, Via Celoria 26, 20133, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Dejana
authors.affiliation: 1] IFOM, FIRC institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy [2] Mario Negri Institute for Pharmacological Research, Via la Masa 19, 20156, Milan, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Lampugnani
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism*; D042783:Endothelial Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D000099152:Cadherin 5
chemical_list: D015703:Antigens, CD; D015820:Cadherins; D042461:Vascular Endothelial Growth Factor A; D000099152:Cadherin 5; C467480:vascular endothelial growth factor A, mouse