title: An enantioselective synthesis of the C24-C40 fragment of (-)-pulvomycin.
abstract: The C24-C40 fragment of (-)-pulvomycin was prepared in enantiomerically pure form using a concise synthesis method (15 linear steps from D-fucose, 6.8% overall yield) featuring a diastereoselective addition to an aldehyde, a β-selective glycosylation and a Stille cross-coupling as the key steps.
authors.affiliation: Lehrstuhl für Organische Chemie I, Technische Universität München, 85747 Garching, Germany. thorsten.bach@ch.tum.de.
authors.forename: Sandra
authors.initials: S
authors.lastname: Börding
authors.forename: Thorsten
authors.initials: T
authors.lastname: Bach
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000617:Aminoglycosides / Q000138:chemical synthesis* / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D005643:Fucose / Q000737:chemistry; D006031:Glycosylation; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C012521:pulvomycin; D005643:Fucose