title: BTNL2 associated with the immune response to hepatitis B vaccination in a Chinese Han population.
abstract: No response to hepatitis B vaccination is a complex phenomenon, which is induced by the combinations of environmental and genetic factors. The aim of the study was to investigate the association between the polymorphisms of the butyrophilin-like 2 (BTNL2) gene and the immune response to hepatitis B vaccination in a Chinese Han population. A total of 7 single nucleotide polymorphisms in the BTNL2 gene were analyzed in 566 non-responders and 1,040 high-responders to hepatitis B vaccination. The alleles T, T, C, A, G of rs3763316, rs3763311, rs9268494, rs3806156, and rs2076530 were associated with no response to hepatitis B vaccination (P = 0.015, odds ratio (OR) = 1.20; P = 0.029, OR = 1.18; P = 2.00E-07, OR = 1.58; P = 0.002, OR = 1.27; P = 2.90E-06, OR = 1.41, respectively). Whereas, the alleles T, C of rs9268501 and rs3763313 played significantly protective roles in the immune response to hepatitis B vaccination (P = 0.007, OR = 0.81; P = 0.004, OR = 0.74). Besides, the risks of no response to hepatitis B vaccination were increased significantly among individuals harbored the haplotypes of G-T-A-T-C-A-G (P = 0.038, OR = 1.48), G-T-A-T-C (P < 0.0001, OR = 2.34), A-A (P < 0.0001, OR = 4.08), and C-G (P < 0.0001, OR = 4.75). However, the haplotype of G-C-A-T-C (P = 1.00E-04, OR = 0.54) exhibited a protective role in the immune response to hepatitis B vaccination in the study. These findings suggest that polymorphisms in the BTNL2 gene might play a vital role in determining the outcome of the immune response to hepatitis B vaccination.
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Science, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.forename: Liping
authors.initials: L
authors.lastname: Pan
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiaopan
authors.initials: X
authors.lastname: Wu
authors.forename: Xilin
authors.initials: X
authors.lastname: Zhu
authors.forename: Bingyu
authors.initials: B
authors.lastname: Yan
authors.forename: Aiqiang
authors.initials: A
authors.lastname: Xu
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D000071797:Butyrophilins; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000276:immunology*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014611:Vaccination / Q000379:methods*
chemical_list: C408263:BTNL2 protein, human; D000071797:Butyrophilins; D017325:Hepatitis B Vaccines; D008562:Membrane Glycoproteins
keywords: butyrophilin-like 2; haplotype; hepatitis B vaccination; linkage disequilibrium; polymorphism