title: Photodynamic therapy as a novel antimicrobial strategy against biofilm-based nosocomial infections: study protocols.
abstract: Hospital-acquired infections (HAIs), also known as nosocomial infections, are one of the most serious health-care issues currently influencing health-care costs. Among them, those sustained by microbial biofilm represent a major public health concern. Here, we describe the experimental protocols for microbial biofilm inactivation relying on antimicrobial photodynamic therapy (APDT) as a new strategy for the control of these kinds of infections.
authors.affiliation: Molteni Therapeutics srl, Via Barontini 8, 50018, Scandicci (Fi), Italy, f.giuliani@moltenitherapeutics.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Giuliani
mesh_terms: D000818:Animals; D018441:Biofilms / Q000187:drug effects*; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology*; D004195:Disease Models, Animal; D006801:Humans; D008027:Light; D051379:Mice; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000502:physiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology
chemical_list: D017319:Photosensitizing Agents