title: Safety evaluation of lasalocid use in Chinese ring-necked pheasants (Phasianus colchicus).
abstract: Coccidiosis remains a significant threat to the welfare of game farm-reared pheasants in the United States. Although lasalocid has been demonstrated to be effective against pheasant specific coccidia, information regarding its safety in this species is lacking. The purpose of this study was to gather data on the safety of lasalocid when fed to Chinese ring-necked pheasants at one, two, and three times the recommended high dose of lasalocid used for prevention of coccidiosis in other poultry at three times the normal treatment period. Pheasant chicks (approximately 1 day-old; n = 160) were randomly blocked by sex into four treatment groups and given their respective diets continuously for 6 wk. No significant differences were observed in overall feed consumption, weight gain, feed conversion rates, clinical pathology measurements, or tissue gross and histopathologic evaluations between controls and treatment groups associated with lasalocid administration. Based on the results of this study it appears that lasalocid fed at the recommended rate of 125 ppm is safe in Chinese ring-necked pheasants.
authors.forename: R S
authors.initials: RS
authors.lastname: Dzikamunhenga
authors.forename: B
authors.initials: B
authors.lastname: Wilberts
authors.forename: M
authors.initials: M
authors.lastname: Yaeger
authors.forename: E
authors.initials: E
authors.lastname: Burrough
authors.forename: J
authors.initials: J
authors.lastname: Hostetter
authors.forename: H
authors.initials: H
authors.lastname: Bender
authors.forename: W
authors.initials: W
authors.lastname: Larson
authors.forename: R W
authors.initials: RW
authors.lastname: Griffith
mesh_terms: D000824:Animal Nutritional Physiological Phenomena / Q000187:drug effects; D000818:Animals; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D046094:Galliformes; D007832:Lasalocid / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D011201:Poultry Diseases / Q000188:drug therapy*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D003049:Coccidiostats; D007832:Lasalocid