title: Metal-free photochemical aromatic perfluoroalkylation of α-cyano arylacetates.
abstract: We report here an operationally simple protocol for the direct aromatic perfluoroalkylation and trifluoromethylation of α-cyano arylacetates. This metal-free approach, which occurs at ambient temperature and under visible-light irradiation, is driven by the photochemical activity of electron donor-acceptor (EDA) complexes, formed in situ by the interaction of transiently generated enolates and perfluoroalkyl iodides. Preliminary mechanistic studies are reported.
authors.affiliation: ICIQ-Institute of Chemical Research of Catalonia, Avenida Països Catalans 16, 43007 Tarragona (Spain) http://www.iciq.es/portal/862/default.aspx.
authors.forename: Manuel
authors.initials: M
authors.lastname: Nappi
authors.forename: Giulia
authors.initials: G
authors.lastname: Bergonzini
authors.forename: Paolo
authors.initials: P
authors.lastname: Melchiorre
keywords: CH functionalization; perfluoroalkylation; photochemistry; synthetic methods; trifluoromethylation