title: [GRADE: Methodology for formulating and grading recommendations in clinical practice].
abstract: Clinical practice guidelines (CPG) provide recommendations on the benefits and harms of different healthcare interventions. Proper CPG development and implementation can potentially reduce variability in clinical practice while improving its quality and safety. The GRADE system is used to assess the quality of evidence and to grade the strength of recommendations in the context of the development of CPGs, systematic reviews or health technology assessments. The aim of this article is to describe the main characteristics of the GRADE system through relevant examples in the context of primary care.
authors.affiliation: Centro Cochrane Iberoamericano, Instituto de Investigación Biomédica (IIB-Sant Pau), Barcelona, España.
authors.forename: Andrea Juliana
authors.initials: AJ
authors.lastname: Sanabria
authors.affiliation: Centro Cochrane Iberoamericano, Instituto de Investigación Biomédica (IIB-Sant Pau), Barcelona, España.
authors.forename: David
authors.initials: D
authors.lastname: Rigau
authors.affiliation: Grupo Kronikgune sobre gestión del conocimiento, Centro de Salud de Alza, Donostia-San Sebastián, España.
authors.forename: Rafael
authors.initials: R
authors.lastname: Rotaeche
authors.affiliation: Centro Cochrane Iberoamericano, Instituto de Investigación Biomédica (IIB-Sant Pau), Barcelona, España.
authors.forename: Anna
authors.initials: A
authors.lastname: Selva
authors.affiliation: Unitat de Suport a la Recerca de Costa de Ponent-Institut d'Investigació en Atenció Primària (IDIAP) Jordi Gol, Direcció d'Atenció Primària Costa de Ponent, Institut Català de la Salut, Barcelona, España.
authors.forename: Mercè
authors.initials: M
authors.lastname: Marzo-Castillejo
authors.affiliation: Centro Cochrane Iberoamericano, Instituto de Investigación Biomédica (IIB-Sant Pau), Barcelona, España. Electronic address: palonso@santpau.cat.
authors.forename: Pablo
authors.initials: P
authors.lastname: Alonso-Coello
mesh_terms: D015510:Clinical Medicine; D019317:Evidence-Based Medicine; D006801:Humans; D017410:Practice Guidelines as Topic / Q000592:standards*
keywords: Adhesión a las guías; Evidence-based medicine; Guideline adherence; Guías de práctica clínica; Medicina basada en la evidencia; Practice guidelines