title: Laparoscopic surgery for double gastrointestinal stromal tumor of the stomach: a report of two cases.
abstract: Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors that originate from interstitial cells of Cajal or their stem cell-like precursors. Generally, GISTs have specific c-KIT gene mutations. The incidence of GISTs is estimated to be 10 to 20 cases/one million individuals, and GISTs typically affect people over 50 years of age. The majority of GISTs are solitary. However, multifocal GISTs have been observed, especially in children. We report on two unusual adult cases of double GISTs that were treated by laparoscopic surgery. The first patient presented a polypoid mass of the fundus and a second isolated smaller tumor in the posterior wall of the lesser curvature of the stomach. A histopathological examination confirmed that both tumors were GISTs and were c-KIT-positive. A total laparoscopic gastrectomy was performed. In the second patient, GISTs were identified at the level of the fundus and the greater curvature of the stomach. A laparoscopic partial sleeve gastrectomy was performed. Both surgeries were successful with no complications or relapses at three to five years following surgery.
authors.affiliation: Digestive and Liver Transplant Surgery Unit, Henri-Mondor Hospital, Université Paris Est, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France. nic.deangelis@yahoo.it.
authors.forename: Nicola
authors.initials: N
authors.lastname: de'Angelis
authors.forename: Riccardo
authors.initials: R
authors.lastname: Memeo
authors.forename: Valeria
authors.initials: V
authors.lastname: Zuddas
authors.forename: Dalila
authors.initials: D
authors.lastname: Mehdaoui
authors.forename: Daniel
authors.initials: D
authors.lastname: Azoulay
authors.forename: Francesco
authors.initials: F
authors.lastname: Brunetti
mesh_terms: D005260:Female; D005743:Gastrectomy; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*