title: The effects of bioactive compounds from plant foods on mitochondrial function: a focus on apoptotic mechanisms.
abstract: Mitochondria are essential organelles for cellular integrity and functionality maintenance and their imparement is implicated in the development of a wide range of diseases, including metabolic, cardiovascular, degenerative and hyperproliferative pathologies. The identification of different compounds able to interact with mitochondria for therapeutic purposes is currently becoming of primary importance. Indeed, it is well known that foods, particularly those of vegetable origin, present several constituents with beneficial effects on health. This review summarizes and updates the most recent findings concerning the mechanisms through which different dietary compounds from plant foods affect mitochondria functionality in healthy and pathological in vitro and in vivo models, paying particular attention to the pathways involved in mitochondrial biogenesis and apoptosis.
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Italy.
authors.forename: Tamara Y
authors.initials: TY
authors.lastname: Forbes-Hernández
authors.affiliation: Dipartimento di Scienze Agrarie, Alimentari ed Ambientali, Università Politecnica delle Marche, Italy. Electronic address: f.giampieri@univpm.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Giampieri
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Gasparrini
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Mazzoni
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, University of Granada, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: Quiles
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Italy; Dipartimento di Scienze Agrarie, Alimentari ed Ambientali, Università Politecnica delle Marche, Italy.
authors.forename: José M
authors.initials: JM
authors.lastname: Alvarez-Suarez
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Italy. Electronic address: m.a.battino@univpm.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Battino
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D006801:Humans; D008928:Mitochondria / Q000187:drug effects*; D001678:Organelle Biogenesis; D018384:Oxidative Stress / Q000187:drug effects; D064209:Phytochemicals / Q000494:pharmacology*; D015398:Signal Transduction; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D004041:Dietary Fats; D064209:Phytochemicals; D014815:Vitamins
keywords: Apoptosis; Dietary bioactive compounds; Mitocondrial functionality; Oxidative stress