title: Multifunctional wearable devices for diagnosis and therapy of movement disorders.
abstract: Wearable systems that monitor muscle activity, store data and deliver feedback therapy are the next frontier in personalized medicine and healthcare. However, technical challenges, such as the fabrication of high-performance, energy-efficient sensors and memory modules that are in intimate mechanical contact with soft tissues, in conjunction with controlled delivery of therapeutic agents, limit the wide-scale adoption of such systems. Here, we describe materials, mechanics and designs for multifunctional, wearable-on-the-skin systems that address these challenges via monolithic integration of nanomembranes fabricated with a top-down approach, nanoparticles assembled by bottom-up methods, and stretchable electronics on a tissue-like polymeric substrate. Representative examples of such systems include physiological sensors, non-volatile memory and drug-release actuators. Quantitative analyses of the electronics, mechanics, heat-transfer and drug-diffusion characteristics validate the operation of individual components, thereby enabling system-level multifunctionalities.
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea [3].
authors.forename: Donghee
authors.initials: D
authors.lastname: Son
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea [3].
authors.forename: Jongha
authors.initials: J
authors.lastname: Lee
authors.affiliation: Center for Mechanics of Solids, Structures and Materials, Department of Aerospace Engineering and Engineering Mechanics, Texas Materials Institute, University of Texas at Austin, 210 E 24th Street, Austin, Texas 78712, USA.
authors.forename: Shutao
authors.initials: S
authors.lastname: Qiao
authors.affiliation: MC10 Inc., 9 Camp Street, Cambridge, Massachusetts 02140, USA.
authors.forename: Roozbeh
authors.initials: R
authors.lastname: Ghaffari
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Jaemin
authors.initials: J
authors.lastname: Kim
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Changyeong
authors.initials: C
authors.lastname: Song
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Seok Joo
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Dong Jun
authors.initials: DJ
authors.lastname: Lee
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Samuel Woojoo
authors.initials: SW
authors.lastname: Jun
authors.affiliation: Center for Mechanics of Solids, Structures and Materials, Department of Aerospace Engineering and Engineering Mechanics, Texas Materials Institute, University of Texas at Austin, 210 E 24th Street, Austin, Texas 78712, USA.
authors.forename: Shixuan
authors.initials: S
authors.lastname: Yang
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Minjoon
authors.initials: M
authors.lastname: Park
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Jiho
authors.initials: J
authors.lastname: Shin
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Kyungsik
authors.initials: K
authors.lastname: Do
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Mincheol
authors.initials: M
authors.lastname: Lee
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Kwanghun
authors.initials: K
authors.lastname: Kang
authors.affiliation: WCU Hybrid Materials Program, Department of Materials Science and Engineering and Inter-university Semiconductor Research Center, Seoul National University, Seoul 151-744, Republic of Korea.
authors.forename: Cheol Seong
authors.initials: CS
authors.lastname: Hwang
authors.affiliation: Center for Mechanics of Solids, Structures and Materials, Department of Aerospace Engineering and Engineering Mechanics, Texas Materials Institute, University of Texas at Austin, 210 E 24th Street, Austin, Texas 78712, USA.
authors.forename: Nanshu
authors.initials: N
authors.lastname: Lu
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Taeghwan
authors.initials: T
authors.lastname: Hyeon
authors.affiliation: 1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Dae-Hyeong
authors.initials: DH
authors.lastname: Kim
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D009069:Movement Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D018482:Muscle, Skeletal / Q000503:physiopathology; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods