title: Clinical presentations of severe cutaneous drug reactions in HIV-infected Africans.
abstract: Sub-Saharan Africa is the epicenter of the HIV pandemic and HIV-infected people are more susceptible to inflammatory dermatoses, infections, and drug eruptions. Many of the drugs used for HIV-associated opportunistic infections are associated with a higher incidence of drug-related toxicities and drug interactions. This article discusses the epidemiology, pharmacogenetics, and clinical features of idiosyncratic drug reactions in HIV-infected Africans. Special considerations in this population, including immune reconstitution inflammatory syndrome, multiple drug hypersensitivity syndrome, drug reactions in pregnancy, drug rechallenge in lichenoid drug eruptions, and anxiety/depression after cutaneous adverse drug reactions, are also briefly discussed.
authors.affiliation: Division of Dermatology, Department of Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa 7925. Electronic address: rannakoe.lehloenya@uct.ac.za.
authors.forename: Rannakoe J
authors.initials: RJ
authors.lastname: Lehloenya
authors.affiliation: Department of Dermatology, University of Pretoria, and Steve Biko Hospital, Dr Savage Street, Pretoria, South Africa 0001.
authors.forename: Mahlatse
authors.initials: M
authors.lastname: Kgokolo
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects*; D044966:Anti-Retroviral Agents / Q000008:administration & dosage / Q000009:adverse effects*; D063926:Drug Hypersensitivity Syndrome / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D008297:Male
chemical_list: D019380:Anti-HIV Agents; D044966:Anti-Retroviral Agents
keywords: Africans; Clinical characteristics; Drug eruptions; HIV; Review