title: Differentiating white matter lesions in multiple sclerosis and migraine using monoexponential and biexponential diffusion measurements.
abstract: OBJECTIVE
  To compare the white matter lesions seen in multiple sclerosis and migraine using monoexponential and high b-value biexponential diffusion measurements.
  
  
  METHODS
  Diffusion-weighted images were acquired on a 3.0-Tesla magnetic resonance imaging system. Diffusion parameters were estimated using monoexponential (0-1000 s/mm(2) ) and biexponential (0-5000 s/mm(2) ) approaches from 15 multiple sclerosis patients, 15 patients with migraine and 15 healthy control subjects. The study was performed in accordance with the approval of the Regional Research Ethics Committee. The apparent diffusion coefficient (ADC) values were measured in the lesions and the normal-appearing white matter of patients and in the white matter of controls.
  
  
  RESULTS
  High lesional ADCmono values were detected in both patient groups without significant differences between the groups (10.72 and 9.86 × 10(-4) mm(2) /s for MS and migraine respectively, P = 0.2134). The biexponential measurements showed significantly higher ADCfast , ADCslow , and Pslow values in the migraine lesions than in the multiple sclerosis lesions (16.47 versus 14.29, 1.41 versus 0.76, and 20.34 versus 12.01 all values in 10(-4) mm(2) /s; P = 0.0344, P = 0.0019, P = 0.0021, respectively).
  
  
  CONCLUSIONS
  Biexponential diffusion analysis may help to differentiate multiple sclerosis-related white matter lesions from migraine-related ones.
authors.affiliation: Diagnostic Centre of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, University of Pécs, Pécs, Hungary.
authors.forename: Gergely
authors.initials: G
authors.lastname: Orsi
authors.forename: Mihály
authors.initials: M
authors.lastname: Aradi
authors.forename: Szilvia Anett
authors.initials: SA
authors.lastname: Nagy
authors.forename: Gábor
authors.initials: G
authors.lastname: Perlaki
authors.forename: Anita
authors.initials: A
authors.lastname: Trauninger
authors.forename: Péter
authors.initials: P
authors.lastname: Bogner
authors.forename: József
authors.initials: J
authors.lastname: Janszky
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Illés
authors.forename: Tamás
authors.initials: T
authors.lastname: Dóczi
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Pfund
authors.forename: Attila
authors.initials: A
authors.lastname: Schwarcz
mesh_terms: D000328:Adult; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008881:Migraine Disorders / Q000473:pathology*; D009103:Multiple Sclerosis / Q000473:pathology*; D011446:Prospective Studies; D015203:Reproducibility of Results; D066127:White Matter / Q000473:pathology*
keywords: brain white matter lesion; migraine; monoexponential and biexponential diffusion analysis; multiple sclerosis