title: Endothelialization of novel magnesium-rare earth alloys with fluoride and collagen coating.
abstract: Magnesium (Mg) alloys are promising scaffolds for the next generation of cardiovascular stents because of their better biocompatibility and biodegradation compared to traditional metals. However, insufficient mechanical strength and high degradation rate are still the two main limitations for Mg materials. Hydrofluoric acid (HF) treatment and collagen coating were used in this research to improve the endothelialization of two rare earth-based Mg alloys. Results demonstrated that a nanoporous film structure of fluoride with thickness of ~20 µm was formed on the Mg material surface, which improved the corrosion resistance. Primary human coronary artery endothelial cells (HCAECs) had much better attachment, spreading, growth and proliferation (the process of endothelialization) on HF-treated Mg materials compared to bare- or collagen-coated ones.
authors.affiliation: Department of Chemical, Biological and Bio-Engineering, NSF Engineering Research Center-Revolutionizing Metallic Biomaterials, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA. nzhao@aggies.ncat.edu.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhao
authors.affiliation: Department of Chemical, Biological and Bio-Engineering, NSF Engineering Research Center-Revolutionizing Metallic Biomaterials, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA. bdworkma@live.unc.edu.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Workman
authors.affiliation: Department of Chemical, Biological and Bio-Engineering, NSF Engineering Research Center-Revolutionizing Metallic Biomaterials, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA. dzhu@ncat.edu.
authors.forename: Donghui
authors.initials: D
authors.lastname: Zhu
mesh_terms: D000497:Alloys / Q000737:chemistry; D001672:Biocompatible Materials; D002460:Cell Line; D049109:Cell Proliferation; D003094:Collagen / Q000737:chemistry / Q000378:metabolism*; D003331:Coronary Vessels / Q000166:cytology / Q000601:surgery*; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology; D005459:Fluorides / Q000737:chemistry; D006801:Humans; D006858:Hydrofluoric Acid / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D008674:Metals, Rare Earth / Q000737:chemistry; D015607:Stents; D013499:Surface Properties
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D008674:Metals, Rare Earth; D003094:Collagen; D008274:Magnesium; D005459:Fluorides; D006858:Hydrofluoric Acid