title: NF-κB mediated regulation of adult hippocampal neurogenesis: relevance to mood disorders and antidepressant activity.
abstract: Adult hippocampal neurogenesis is a peculiar form of process of neuroplasticity that in recent years has gained great attention for its potential implication in cognition and in emotional behavior in physiological conditions. Moreover, a vast array of experimental studies suggested that adult hippocampal neurogenesis may be altered in various neuropsychiatric disorders, including major depression, where its disregulation may contribute to cognitive impairment and/or emotional aspects associated with those diseases. An intriguing area of interest is the potential influence of drugs on adult neurogenesis. In particular, several psychoactive drugs, including antidepressants, were shown to positively modulate adult hippocampal neurogenesis. Among molecules which could regulate adult hippocampal neurogenesis the NF- κ B family of transcription factors has been receiving particular attention from our and other laboratories. Herein we review recent data supporting the involvement of NF- κ B signaling pathways in the regulation of adult neurogenesis and in the effects of drugs that are endowed with proneurogenic and antidepressant activity. The potential implications of these findings on our current understanding of the process of adult neurogenesis in physiological and pathological conditions and on the search for novel antidepressants are also discussed.
authors.affiliation: Laboratory of Neuroplasticity, Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
authors.forename: Valeria
authors.identifier: 0000-0001-9932-1805
authors.initials: V
authors.lastname: Bortolotto
authors.affiliation: Laboratory of Neuroplasticity, Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
authors.forename: Bruna
authors.identifier: 0000-0001-6234-5264
authors.initials: B
authors.lastname: Cuccurazzu
authors.affiliation: Laboratory of Neuroplasticity, Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
authors.forename: Pier Luigi
authors.identifier: 0000-0003-2879-9064
authors.initials: PL
authors.lastname: Canonico
authors.affiliation: Laboratory of Neuroplasticity, Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Grilli
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy* / Q000473:pathology; D016328:NF-kappa B / Q000378:metabolism*; D055495:Neurogenesis / Q000187:drug effects*
chemical_list: D000928:Antidepressive Agents; D016328:NF-kappa B