title: EHPG iron(III) complexes as potential contrast contrast agents for MRI.
abstract: A series of EHPG ligands and complexes were obtained. The derivatives of choice were p-OMe, 3,4-dimethyl, p-NHAc and p-Ph substituted ones. The complexes were characterized by NMR relaxation decay (T1), EPR and cyclic voltammetry (CV). r1 Relaxivity of the Fe-EHPG-OMe, Fe-EHPG-Ph derivatives was found higher than that of Fe-EHPG. EPR measurements at liquid nitrogen temperature indicate a typical rhombohedral structure for both rac- and meso-diastereoisomers of the EHPG complexes. CV revealed the redox inactivity of the Fe-EHPG complexes at physiological conditions. Interpretation and discussion of the results is presented.
authors.forename: Nikodem
authors.initials: N
authors.lastname: Kuźnik
authors.forename: Paweł
authors.initials: P
authors.lastname: Jewuła
authors.forename: Lidia
authors.initials: L
authors.lastname: Oczek
authors.forename: Sylwia
authors.initials: S
authors.lastname: Kozłowicz
authors.forename: Artur
authors.initials: A
authors.lastname: Grucela
authors.forename: Wojciech
authors.initials: W
authors.lastname: Domagała
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D005029:Ethylenediamines / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007501:Iron / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D005029:Ethylenediamines; D009942:Organometallic Compounds; C011813:ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid); D007501:Iron