title: The onset location of neuromyelitis optica spectrum disorder predicts the location of subsequent relapses.
abstract: We evaluated whether the location of the initial attack predicted the locations of subsequent events in neuromyelitis optica spectrum disorder (NMOSD). In the retrospective analysis from 164 patients with NMOSD, increased odds of a second attack occurring in the initial event location were seen in all locations (odds ratio [OR] brain: 16.00; brainstem: 4.42; optic nerve: 4.08; and spinal cord: 4.59), as was a positive linear trend when evaluating the number of previous events in the same location as the third event location (OR brain: 62.52; brainstem: 44.55; optic nerve: 6.48; and spinal cord: 2.98). This study suggests early clinical events of NMOSD tend to recur in the same anatomical location within the central nervous system (CNS).
authors.affiliation: Pontifical Catholic University of Rio Grande do Sul, Science Without Borders, Brazil/Department of Neurology, Research Institute and Hospital of National Cancer Center, Korea.
authors.forename: Manuella Edler
authors.initials: ME
authors.lastname: Zandoná
authors.affiliation: Department of Neurology, Research Institute and Hospital of National Cancer Center, Korea.
authors.forename: Su-Hyun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Neurology, Research Institute and Hospital of National Cancer Center, Korea.
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Hyun
authors.affiliation: Biometric Research Branch, Research Institute and Hospital of National Cancer Center, Korea.
authors.forename: Boram
authors.initials: B
authors.lastname: Park
authors.affiliation: Biometric Research Branch, Research Institute and Hospital of National Cancer Center, Korea.
authors.forename: Jungnam
authors.initials: J
authors.lastname: Joo
authors.affiliation: Department of Neurology, Research Institute and Hospital of the National Cancer Center, 323 Ilsan Street, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Korea hojinkim@ncc.re.kr.
authors.forename: Ho Jin
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D001933:Brain Stem / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000473:pathology* / Q000628:therapy; D009900:Optic Nerve / Q000473:pathology*; D010956:Plasmapheresis; D020127:Recovery of Function; D012008:Recurrence; D012189:Retrospective Studies; D013116:Spinal Cord / Q000473:pathology*; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone
keywords: Neuromyelitis optica; aquaporin-4; neuromyelitis optica spectrum disorder; onset location