title: Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus.
abstract: Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers specific for the capsid protein of swine HEV were significantly higher for all groups of mice immunized with the VLPs than those of the negative control mice. Splenocytes from mice immunized with the VLPs also produced significantly greater quantities of interferon (IFN)-γ than interleukin (IL)-4 and IL-10. These newly developed swine HEV VLPs have the capacity to induce antigen-specific antibody and IFN-γ production in immunized mice.
authors.affiliation: Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
authors.forename: Young-Jo
authors.initials: YJ
authors.lastname: Song
authors.forename: Woo-Jung
authors.initials: WJ
authors.lastname: Park
authors.forename: Seul-Kee
authors.initials: SK
authors.lastname: Lee
authors.forename: Joong-Bok
authors.initials: JB
authors.lastname: Lee
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Park
authors.forename: Chang-Seon
authors.initials: CS
authors.lastname: Song
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Lee
authors.forename: Kun-Ho
authors.initials: KH
authors.lastname: Seo
authors.forename: Young-Sun
authors.initials: YS
authors.lastname: Kang
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Song
authors.forename: In-Soo
authors.initials: IS
authors.lastname: Choi
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D036022:Capsid Proteins / Q000276:immunology; D005260:Female; D016751:Hepatitis E / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D016752:Hepatitis E virus / Q000276:immunology*; D007114:Immunization / Q000662:veterinary*; D007371:Interferon-gamma / Q000097:blood; D051379:Mice; D008807:Mice, Inbred BALB C; D013552:Swine; D013553:Swine Diseases / Q000276:immunology* / Q000821:virology; D058425:Vaccines, Virus-Like Particle / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D036022:Capsid Proteins; D058425:Vaccines, Virus-Like Particle; D014761:Viral Hepatitis Vaccines; D007371:Interferon-gamma
keywords: interferon-γ; swine hepatitis E virus; virus-like particle