title: Resistant hypertension: is renal denervation the current treatment of choice?
abstract: BACKGROUND
  Resistant hypertension is simply defined as failure to control blood pressure <140/90 mmHg in an adherent non-diabetic patient with normal kidney function despite the use of optimal doses of three antihypertensive agents, including a diuretic. Also, control of blood pressure in any adherent patient with more than four antihypertensive agents defines resistant hypertension. In a patient with diabetes or chronic kidney disease, the goal blood pressure is <130/80 mmHg. One of the most important pathophysiological mechanisms of resistant hypertension is overactivity of the sympathetic nervous system (SNS). In selected patients with resistant hypertension, renal denervation has been shown to control blood pressure by suppressing SNS overactivity.
  
  
  CONCLUSIONS
  This review summarizes the results of the studies of renal denervation for resistant hypertension and suggests the use of this procedure in several other conditions that are associated with SNS overactivity.
  
  
  CONCLUSIONS
  Renal denervation seems to control blood pressure in patients with resistant hypertension.
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension, Rutgers, New Jersey Medical School , Newark, NJ , USA.
authors.forename: Alluru S
authors.initials: AS
authors.lastname: Reddi
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004351:Drug Resistance; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D007668:Kidney / Q000294:innervation*; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D013562:Sympathectomy / Q000009:adverse effects; D013564:Sympathetic Nervous System / Q000503:physiopathology; D017211:Treatment Failure
chemical_list: D000959:Antihypertensive Agents
keywords: Catheter devices; renal denervation; resistant hypertension