title: Primate short-wavelength cones share molecular markers with rods.
abstract: Macaca, Callithrix jacchus marmoset monkey, Pan troglodytes chimpanzee and human retinas were examined to define if short wavelength (S) cones share molecular markers with L&M cone or rod photoreceptors. S cones showed consistent differences in their immunohistochemical staining and expression levels compared to L&M cones for "rod" Arrestin1 (S-Antigen), "cone" Arrestin4, cone alpha transducin, and Calbindin. Our data verify a similar pattern of expression in these primate retinas and provide clues to the structural divergence of rods and S cones versus L&M cones, suggesting S cone retinal function is "intermediate" between them.
authors.affiliation: Mary D. Allen Laboratory for Vision Research, Doheny Eye Institute, Departments of Ophthalmology and Cell & Neurobiology, Keck School of Medicine of the University of Southern California, 1355 San Pablo St., DVRC 405, 90033, Los Angeles, CA, USA, ccraft@usc.edu.
authors.forename: Cheryl M
authors.initials: CM
authors.lastname: Craft
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Possin
authors.forename: Anita
authors.initials: A
authors.lastname: Hendrickson
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D064092:Calbindin 1 / Q000378:metabolism; D002144:Callithrix; D055358:Cone Opsins / Q000378:metabolism*; D006801:Humans; D008027:Light; D008251:Macaca; D002679:Pan troglodytes; D017949:Retinal Cone Photoreceptor Cells / Q000378:metabolism*; D017948:Retinal Rod Photoreceptor Cells / Q000378:metabolism*; D017299:Rod Opsins / Q000378:metabolism*; D015293:Transducin / Q000378:metabolism
chemical_list: D015415:Biomarkers; D064092:Calbindin 1; D055358:Cone Opsins; D017299:Rod Opsins; D015293:Transducin