title: [The effects of a very low carbohydrate diet intervention on improving cardiovascular risk factors in obese subjects].
abstract: OBJECTIVE
  To investigate the effects of a very low carbohydrate diet (VLCD) on improving cardiovascular risk factors in obese individuals.
  
  
  METHODS
  A 8-week VLCD was given to 35 healthy obese subjects and the control group was consisted of 35 healthy volunteers. Multi-cardiovascular risk factors were investigated, including weight, waist circumference, BMI, blood pressure, fasting plasma glucose (FPG), fasting insulin (FIns), lipid profiles, urinary albumin-creatinine ratio (UACR), C-reactive protein (CRP) , TNFα and adiponectin.
  
  
  RESULTS
  At the baseline of the study, compared with the healthy control group, all the cardiovascular risk factors were significantly more deteriorated in the obese subjects (all P values <0.05). At the end of the study, the obese subjects showed significant decrease in their mean weight and waist circumference [(8.5 ± 0.7) kg and (6.6 ± 1.1)cm, respectively; all P values < 0.01]. Significant decrease was also found in the levels of systolic blood pressure (SBP), diastolic blood pressure (DBP), FIns, TC and TG (all P values < 0.05), while no significant change of FPG, HDL-C and LDL-C. The levels of UACR, CRP and TNFα were all significantly decreased [(1.86 ± 0.86) µg/mg, (1.15 ± 0.45) mg/L and (0.94 ± 0.21) ng/L, respectively; all P values < 0.05], while the level of adiponectin was significantly increased [(2.12 ± 0.59) mg/L, P < 0.01].
  
  
  CONCLUSIONS
  VLCD is an effective intervention in obese subjects which could improve the cardiovascular risk factors by the modest weight loss.
authors.forename: Yunjuan
authors.initials: Y
authors.lastname: Gu
authors.forename: Shiwei
authors.initials: S
authors.lastname: Cui
authors.forename: Haoyong
authors.initials: H
authors.lastname: Yu
authors.forename: Cheng
authors.initials: C
authors.lastname: Hu
authors.forename: Junxi
authors.initials: J
authors.lastname: Lu
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Ma
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Key Laboratory of Diabetes Mellitus; Shanghai Diabetes Institute; Shanghai Clinical Centre of Diabetes, Shanghai 200233, China. Email: wpjia@sjtu.edu.cn.
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000517:prevention & control; D016022:Case-Control Studies; D050528:Diet, Carbohydrate-Restricted; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000453:epidemiology*; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D008055:Lipids; D002097:C-Reactive Protein