title: Bariatric surgery decreases the risk of uterine malignancy.
abstract: OBJECTIVE
  To describe the risk of uterine malignancy among women who have had weight loss surgery.
  
  
  METHODS
  We performed a retrospective cohort study among inpatient admissions of women 18years, or older, registered in the University HealthSystem Consortium (UHC) dataset. The rate of uterine malignancy per hospital admission was calculated. Rates were compared according to whether diagnoses at the time of discharge included history of bariatric surgery, and further, according to whether there was a diagnosis of obesity.
  
  
  RESULTS
  In admissions of patients who did not have a history of prior bariatric surgery, the rate of uterine malignancy was 599/100,000 (95% CI 590 to 610). Among obese women who had not previously undergone bariatric operations, the rate was 1409/100,000 (95% CI 1380 to 1440). Of women admitted who had a history of bariatric surgery, the rate of uterine malignancy was 408/100,000 (95% CI 370 to 450). The relative risk of uterine malignancy in all admissions for women who had prior bariatric surgery, compared to obese women who had not had bariatric surgery, was 0.29 (95% CI 0.26-0.32). Among women who had bariatric surgery and were not currently obese, the relative risk of uterine malignancy was 0.19 (95% CI 0.17-0.22) compared to obese women who had not undergone bariatric surgery.
  
  
  CONCLUSIONS
  A history of bariatric surgery is associated with a 71% reduced risk for uterine malignancy overall, and an 81% reduced risk if normal weight is maintained after surgery. This finding suggests that obesity may be a modifiable risk factor related to development of endometrial cancer.
authors.affiliation: Rebecca and John Moores UCSD Cancer Center, Department of Reproductive Medicine, Division of Gynecologic Oncology, La Jolla, CA, USA. Electronic address: kristy.kay.ward@gmail.com.
authors.forename: Kristy K
authors.initials: KK
authors.lastname: Ward
authors.affiliation: The University of Texas School of Public Health, Center for Health Promotion and Prevention Research, Houston, TX, USA.
authors.forename: Angelica M
authors.initials: AM
authors.lastname: Roncancio
authors.affiliation: Rebecca and John Moores UCSD Cancer Center, Department of Reproductive Medicine, Division of Gynecologic Oncology, La Jolla, CA, USA.
authors.forename: Nina R
authors.initials: NR
authors.lastname: Shah
authors.affiliation: Rebecca and John Moores UCSD Cancer Center, Department of Reproductive Medicine, Division of Gynecologic Oncology, La Jolla, CA, USA.
authors.forename: Mitzie-Ann
authors.initials: MA
authors.lastname: Davis
authors.affiliation: Rebecca and John Moores UCSD Cancer Center, Department of Reproductive Medicine, Division of Gynecologic Oncology, La Jolla, CA, USA.
authors.forename: Cheryl C
authors.initials: CC
authors.lastname: Saenz
authors.affiliation: Rebecca and John Moores UCSD Cancer Center, Department of Reproductive Medicine, Division of Gynecologic Oncology, La Jolla, CA, USA.
authors.forename: Michael T
authors.initials: MT
authors.lastname: McHale
authors.affiliation: Rebecca and John Moores UCSD Cancer Center, Department of Reproductive Medicine, Division of Gynecologic Oncology, La Jolla, CA, USA.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Plaxe
mesh_terms: D050110:Bariatric Surgery; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000601:surgery*; D012189:Retrospective Studies; D012306:Risk; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000453:epidemiology*
keywords: Bariatric surgery; Obesity; Uterine cancer; Weight reduction