title: Schizophrenia and bipolar disorder show both common and distinct changes in cortical interneuron markers.
abstract: Schizophrenia and bipolar disorder are often viewed as distinct clinical disorders, however there is substantial overlap in their neuropathologies. While compromised cortical interneurons are implicated in both diseases, few studies have examined the relative contribution of the distinct interneuron populations to each psychotic disorder. We report reductions in somatostatin and vasoactive intestinal peptide mRNAs in prefrontal and orbitofrontal cortices in bipolar disorder (n=31) and schizophrenia (n=35) compared to controls (n=34) and increased calbindin mRNA in schizophrenia. We show, at the molecular level, shared deficits in interneuron markers in schizophrenia and bipolar disorder, and a unique interneuron marker increase in schizophrenia.
authors.affiliation: Schizophrenia Research Institute, Sydney, NSW, Australia; Schizophrenia Research Laboratory, Neuroscience Research Australia, Sydney, Australia; School of Psychiatry, University of New South Wales, Sydney, Australia. Electronic address: s.fung@neura.edu.au.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Fung
authors.affiliation: Schizophrenia Research Institute, Sydney, NSW, Australia; Schizophrenia Research Laboratory, Neuroscience Research Australia, Sydney, Australia; School of Psychiatry, University of New South Wales, Sydney, Australia.
authors.forename: Stu G
authors.initials: SG
authors.lastname: Fillman
authors.affiliation: Stanley Medical Research Institute, Chevy Chase, MD, USA.
authors.forename: Maree J
authors.initials: MJ
authors.lastname: Webster
authors.affiliation: Schizophrenia Research Institute, Sydney, NSW, Australia; Schizophrenia Research Laboratory, Neuroscience Research Australia, Sydney, Australia; School of Psychiatry, University of New South Wales, Sydney, Australia.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Shannon Weickert
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D001714:Bipolar Disorder / Q000473:pathology*; D064026:Calbindins / Q000235:genetics / Q000378:metabolism; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D007395:Interneurons / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D012559:Schizophrenia / Q000473:pathology*; D013004:Somatostatin / Q000235:genetics / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; D064026:Calbindins; D012333:RNA, Messenger; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin
keywords: Calbindin; Postmortem; Somatostatin; Vasoactive intestinal peptide; mRNA