title: Survivin expression correlates with nodal metastasis in T1-T2 squamous cell carcinoma of the tongue.
abstract: In this study, the correlation between neck metastasis and recurrence was investigated by studying specimens of tongue squamous cell carcinoma patients immunohistochemical with survivin antibodies in the primary biopsy. A retrospective review was conducted at the Academic University Hospital. 46 patients who had squamous cell carcinoma of the tongue, who underwent various types of glossectomy and neck dissections between 1991 and 2008, were evaluated. The patient's sex, TNM staging, differentiation and recurrence rates were analyzed. There were 20 T1 patients and 26 T2 patients; 27 of the patients were N0 and 19 had metastatic lymph nodes in the neck. Survivin antibodies were applied with streptavidin-biotin method to the sections that were prepared from the primary tumor biopsy specimens of the patients. The correlation between neck metastasis and recurrence and survivins' immunohistochemical staining was analyzed with statistical methods. There were no significant differences between the patient's age, sex, tumor's T stage, tumor differentiation and survivin staining density. Survivin staining was positive in 15 (79 %) of 19 patients with neck metastasis, while it was positive in 16 (59 %) of 27 patients without neck metastasis. Eleven (79 %) of the 14 patients who had recurrence and all 6 patients who had neck recurrence only were stained by survivin. Expression of nuclear and cytoplasmic survivin can be a useful marker for predicting cervical lymph node metastasis in T1-T2 tumors in tongue SCC.
authors.affiliation: Research and Traınıng Hospital, Kayseri, Turkey, drmdogan@hotmail.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Doğan
authors.forename: Sedat
authors.initials: S
authors.lastname: Çağlı
authors.forename: İmdat
authors.initials: İ
authors.lastname: Yüce
authors.forename: Ali
authors.initials: A
authors.lastname: Bayram
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Somdaş
authors.forename: Duran
authors.initials: D
authors.lastname: Karataş
authors.forename: Mehmet Celalettin
authors.initials: MC
authors.lastname: Cihan
authors.forename: Fatih
authors.initials: F
authors.lastname: Yüksel
authors.forename: Ercihan
authors.initials: E
authors.lastname: Güney
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins / Q000276:immunology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D000077022:Survivin; D014062:Tongue Neoplasms / Q000473:pathology*
chemical_list: D000906:Antibodies; C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin