title: The dialysis procedure as a trigger for atrial fibrillation: new insights in the development of atrial fibrillation in dialysis patients.
abstract: OBJECTIVE
  Atrial fibrillation (AF) is common in dialysis patients and is associated with increased morbidity and mortality. The pathophysiology may be related to common risk factors for both AF and renal disease or to dialysis-specific factors. The purpose of this study was to determine whether and how AF onset relates to the dialysis procedure itself.
  
  
  METHODS
  All dialysis patients enrolled in the implantable cardioverter defibrillator-2 (ICD-2) trial until January 2012, who were implanted with an ICD, were included in this study. Using the ICD remote monitoring function, the exact time of onset of all AF episodes was registered. Subsequently, this was linked to the timing of dialysis procedures.
  
  
  RESULTS
  For the current study, a total of 40 patients were included, follow-up was 28 ± 16 months, 80% male, 70 ± 8 years old. A total of 428 episodes of AF were monitored in 14 patients. AF onset was more frequent on the days of haemodialysis (HD) (p<0.001) and specifically increased during the dialysis procedure itself (p=0.04). Patients with AF had a larger left atrium (p<0.001) and a higher systolic blood pressure before and after HD (p<0.001).
  
  
  CONCLUSIONS
  This study provides insight in the exact timing of AF onset in relation to the dialysis procedure itself. In HD patients, AF occurred significantly more often on a dialysis day and especially during HD. These findings might help to elucidate some aspects of the pathophysiology of AF in dialysis patients and could facilitate early detection of AF in these high-risk patients.
authors.affiliation: Department of Cardiology, Leiden University Medical Center (LUMC), , Leiden, The Netherlands.
authors.forename: M S
authors.initials: MS
authors.lastname: Buiten
authors.forename: M K
authors.initials: MK
authors.lastname: de Bie
authors.forename: J I
authors.initials: JI
authors.lastname: Rotmans
authors.forename: B A
authors.initials: BA
authors.lastname: Gabreëls
authors.forename: W
authors.initials: W
authors.lastname: van Dorp
authors.forename: R
authors.initials: R
authors.lastname: Wolterbeek
authors.forename: S A
authors.initials: SA
authors.lastname: Trines
authors.forename: M J
authors.initials: MJ
authors.lastname: Schalij
authors.forename: J W
authors.initials: JW
authors.lastname: Jukema
authors.forename: T J
authors.initials: TJ
authors.lastname: Rabelink
authors.forename: L
authors.initials: L
authors.lastname: van Erven
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D016757:Death, Sudden, Cardiac / Q000517:prevention & control*; D017147:Defibrillators, Implantable; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D006435:Renal Dialysis / Q000009:adverse effects*; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors
keywords: Renal Disease