title: Impaired glucose regulation predicted 1-year mortality of Chinese patients with ischemic stroke: data from abnormal glucose regulation in patients with acute stroke across China.
abstract: OBJECTIVE
  It remains uncertain if impaired glucose regulation (IGR) as a predictor for stroke outcomes. This study aimed at observing the effect of IGR on the 1-year outcomes in Chinese patients with ischemic stroke.
  
  
  METHODS
  Patients with acute ischemic stroke were recruited consecutively in multihospitals across China. Oral glucose tolerance test was performed to identify IGR. Cox proportion hazard model was performed to investigate the effect of IGR on 1-year mortality or stroke recurrence in patients with ischemic stroke.
  
  
  RESULTS
  The study recruited 2639 patients with ischemic stroke. IGR was shown as an independent risk factor for the mortality of patients with ischemic stroke (hazard ratio [95% confidence interval], 3.088 [1.386-6.884]; P=0.006). However, IGR showed no significant effects on the dependency or stroke recurrence of patients (P=0.540 and 0.618, respectively).
  
  
  CONCLUSIONS
  IGR was an independent predictor for the mortality of patients with ischemic stroke. IGR should be highlighted and intervened actively in the patients with ischemic stroke.
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Jia
authors.forename: Gaifen
authors.initials: G
authors.lastname: Liu
authors.forename: Huaguang
authors.initials: H
authors.lastname: Zheng
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.forename: Chunxue
authors.initials: C
authors.lastname: Wang
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wang
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis* / Q000096:biosynthesis / Q000378:metabolism; D002545:Brain Ischemia / Q000453:epidemiology / Q000378:metabolism / Q000401:mortality*; D002681:China / Q000453:epidemiology; D005260:Female; D015600:Glasgow Coma Scale; D044882:Glucose Metabolism Disorders / Q000453:epidemiology*; D005951:Glucose Tolerance Test / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000453:epidemiology / Q000378:metabolism / Q000401:mortality*; D013997:Time Factors
chemical_list: D001786:Blood Glucose
keywords: cerebral infarction; mortality; prediabetes