title: Recent advances in the design of artificial corneas.
abstract: OBJECTIVE
  Artificial corneas are being developed to meet a shortage of donor corneas and to address cases in which allografting is contraindicated. A range of artificial corneas has been developed. Here we review several newer designs and especially those inspired by naturally occurring biomaterials found with the human body and elsewhere.
  
  
  RESULTS
  Recent trends in the development of artificial corneas indicate a move towards the use of materials derived from native sources including decellularized corneal tissue and tissue substitutes synthesized by corneal cells in vitro when grown either on their own or in conjunction with novel protein-based scaffolds. Biologically inspired materials are also being considered for implantation on their own with the view to promoting endogenous corneal tissue.
  
  
  CONCLUSIONS
  More recent attempts at making artificial corneas have taken a more nature-based or nature-inspired approach. Several will in the near future be likely to be available clinically.
authors.affiliation: aIntegrative Regenerative Medicine Centre, Department of Clinical and Experimental Medicine, Linköping University, -Linköping, Sweden bSchool of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, and Queensland Eye Institute, South Brisbane, QLD, Australia.
authors.forename: May
authors.initials: M
authors.lastname: Griffith
authors.forename: Damien G
authors.initials: DG
authors.lastname: Harkin
mesh_terms: D001187:Artificial Organs; D003315:Cornea; D016039:Corneal Transplantation; D006801:Humans; D023822:Tissue Engineering / Q000379:methods