title: Combination and comparison of two models in prognosis of pulmonary embolism: results from TUrkey Pulmonary Embolism Group (TUPEG) study.
abstract: BACKGROUND
  Clinical parameters, biomarkers and imaging-based risk stratification are widely accepted in pulmonary embolism(PE). The present study has investigated the prognostic role of simplified Pulmonary Embolism Severity Index (sPESI) score and the European Society of Cardiology (ESC) model.
  
  
  METHODS
  This prospective cohort study included a total of 1078 patients from a multi-center registry, with objectively confirmed acute symptomatic PE. The primary endpoint was all-cause mortality during the first 30days, and the secondary endpoint included all-cause mortality, nonfatal symptomatic recurrent PE, or nonfatal major bleeding.
  
  
  RESULTS
  Of the 1078 study patients, 95 (8.8%) died within 30days of diagnosis. There was no significant difference between non-low-risk patients ESC [12.2% (103 of 754;)] and high-risk patients as per the sPESI [11.6% (103 of 796)] for 30-day mortality. The nonfatal secondary endpoint occurred in 2.8% of patients in the the sPESI low-risk and 1.9% in the ESC low-risk group. Thirty-day mortality occurred in 2.2% of patients the sPESI low-risk and in 2.2% the ESC low-risk group (P=NS). In the present study, in the combination of the sPESI low-risk and ESC model low-risk mortality rate was 0%.
  
  
  CONCLUSIONS
  The sPESI and the ESC model showed a similar performance regarding 30-day mortality and secondary outcomes in the present study. However, the combination of these two models appears to be particularly valuable in PE.
authors.affiliation: Karadeniz Technical University, School of Medicine, Department of Pulmonary Medicine, Trabzon, Turkey. Electronic address: savasozsu@gmail.com.
authors.forename: Savas
authors.initials: S
authors.lastname: Ozsu
authors.affiliation: Karadeniz Technical University, School of Medicine, Department of Pulmonary Medicine, Trabzon, Turkey. Electronic address: ozlutevfik@yahoo.com.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Ozlu
authors.affiliation: Ankara Atatürk Training and Research Hospital, Department of Pulmonary Medicine, Ankara,Turkey. Electronic address: asenturk1967@yahoo.com.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Sentürk
authors.affiliation: Atatürk University School of Medicine, Department of Pulmonary Medicine, Erzurum, Turkey. Electronic address: eucar1979@yahoo.com.
authors.forename: Elif Yılmazel
authors.initials: EY
authors.lastname: Uçar
authors.affiliation: Fırat University School of Medicine, Department of Chest, Pulmonary Medicine, Turkey. Electronic address: gamkirkil@yahoo.com.
authors.forename: Gamze
authors.initials: G
authors.lastname: Kırkıl
authors.affiliation: Erzurum Regional Training and Research Hospital, Department of Pulmonary Medicine, Erzurum, Turkey. Electronic address: esraekbic@hotmail.com.
authors.forename: Esra Ekbiç
authors.initials: EE
authors.lastname: Kadıoğlu
authors.affiliation: Bülent Ecevit University School of Medicine, Department of Pulmonary Medicine, Zonguldak, Turkey. Electronic address: balt1907@yahoo.com.
authors.forename: Bülent
authors.initials: B
authors.lastname: Altınsoy
authors.affiliation: Ümraniye Training and Research Hospital, Department of Pulmonary Medicine, İstanbul, Turkey. Electronic address: metebengu@yahoo.com.
authors.forename: Bengü
authors.initials: B
authors.lastname: Saylan
authors.affiliation: Dicle University School of Medicine, Department of Pulmonary Medicine, Diyarbakır, Turkey. Electronic address: dr.haticesen@hotmail.com.
authors.forename: Hatice Şen
authors.initials: HŞ
authors.lastname: Selimoğlu
authors.affiliation: Koşuyolu Training and Research Hospital, Department of Pulmonary Medicine, İstanbul, Turkey. Electronic address: dgrdabak@hotmail.com.
authors.forename: Gül
authors.initials: G
authors.lastname: Dabak
authors.affiliation: Erciyes University School of Medicine, Department of Pulmonary Medicine, Kayseri, Turkey. Electronic address: drnuritutar@gmail.com.
authors.forename: Nuri
authors.initials: N
authors.lastname: Tutar
authors.affiliation: Ege University School of Medicine, Department of Pulmonary Medicine, İzmir, Turkey. Electronic address: ahmet-bh@hotmail.com.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Uysal
mesh_terms: D000368:Aged; D015331:Cohort Studies; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000000981:diagnostic imaging; D018570:Risk Assessment; D014421:Turkey