title: Antenatal taurine supplementation increases taurine content in intrauterine growth restricted fetal rat brain tissue.
abstract: This study aimed to determine the influence of antenatal taurine supplementation on taurine content in the brains of fetal rats with intrauterine growth restriction (IUGR). Experiments were performed at the Central Laboratory of Bayi Children's Hospital Affiliated to Beijing Military General Hospital in China from January to June 2013. Fifteen pregnant rats were randomly divided into three groups: normal controls, an IUGR group and an IUGR + antenatal taurine supplement group (Taurine group) (n = 5). The IUGR model was induced using a low-protein diet throughout gestation. Rats in the taurine group were fed a diet supplemented with 300 mg/kg/day taurine for 12 days after conception until natural delivery. Two fetal rats were randomly selected in every litter, and taurine levels in the brains of rats were detected using high-performance liquid chromatography-mass spectrometry. Results showed that (1) the mean body weight of the fetal rats in the normal control, IUGR and IUGR + antenatal taurine supplement groups was 6.619 ± 0.4132, 4.509 ± 0.454, and 5.176 ± 0.436 g (F = 429.818, P < 0.01), respectively, and (2) that taurine levels in the brains of the fetal rats in the normal control, IUGR and taurine groups were (2.399 ± 0.134) × 10(5), (1.881 ± 0.166) × 10(5) and (2.170 ± 0.191) × 10(5) μg/g (F = 24.828, P < 0.01), respectively. Overall, our results indicated that taurine levels in IUGR fetal rat brains were lower than in the control animals, and that antenatal taurine supplementation could significantly increase taurine levels in the brains of fetal rats with IUGR.
authors.affiliation: Department of Pediatrics, The Second Artillery General Hospital of Chinese People's Liberation Army, Beijing, 100088, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.forename: Hui-Yun
authors.initials: HY
authors.lastname: Teng
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Hua-Wei
authors.initials: HW
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D013654:Taurine