title: DrugPath: a database for academic investigators to match oncology molecular targets with drugs in development.
abstract: OBJECTIVE
  Academic laboratories are developing increasingly large amounts of data that describe the genomic landscape and gene expression patterns of various types of cancers. Such data can potentially identify novel oncology molecular targets in cancer types that may not be the primary focus of a drug sponsor's initial research for an investigational new drug. Obtaining preclinical data that point toward the potential for a given molecularly targeted agent, or a novel combination of agents requires knowledge of drugs currently in development in both the academic and commercial sectors.
  
  
  METHODS
  We have developed the DrugPath database ( http://www.drugpath.org ) as a comprehensive, free-of-charge resource for academic investigators to identify agents being developed in academics or industry that may act against molecular targets of interest. DrugPath data on molecular targets overlay the Michigan Molecular Interactions ( http://mimi.ncibi.org ) gene-gene interaction map to facilitate identification of related agents in the same pathway.
  
  
  RESULTS
  The database catalogs 2,081 drug development programs representing 751 drug sponsors and 722 molecular and genetic targets.
  
  
  CONCLUSIONS
  DrugPath should assist investigators in identifying and obtaining drugs acting on specific molecular targets for biological and preclinical therapeutic studies.
authors.affiliation: Cancer Center and Departments of Cell Biology and Biochemistry, Pediatrics, and Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, 3601 4th St, STOP 9445, Lubbock, TX, 79430, USA.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Shah
authors.forename: Brandon M A
authors.initials: BM
authors.lastname: Fisch
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Arceci
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Buckley
authors.forename: Gregory H
authors.initials: GH
authors.lastname: Reaman
authors.forename: Poul H
authors.initials: PH
authors.lastname: Sorensen
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Triche
authors.forename: C Patrick
authors.initials: CP
authors.lastname: Reynolds
mesh_terms: D016208:Databases, Factual; D015195:Drug Design; D055808:Drug Discovery; D015507:Drugs, Investigational / Q000627:therapeutic use*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D015507:Drugs, Investigational