title: Drug dosage in isolated limb perfusion: evaluation of a limb volume model for extremity volume calculation.
abstract: BACKGROUND
  Exact drug dosing in isolated limb perfusion (ILP) and infusion (ILI) is essential. We developed and evaluated a model for calculating the volume of extremities and compared this model with body weight- and height-dependent parameters.
  
  
  METHODS
  The extremity was modeled by a row of coupled truncated cones. The sizes of the truncated cone bases were derived from the circumference measurements of the extremity at predefined levels (5 cm). The resulting volumes were added. This extremity volume model was correlated to the computed tomography (CT) volume data of the extremity (total limb volume). The extremity volume was also correlated with the patient's body weight, body mass index (BMI) and ideal body weight (IBW). The no-fat CT limb volume was correlated with the circumference-measured limb volume corrected by the ideal-body-weight to actual-body-weight ratio (IBW corrected-limb-volume).
  
  
  RESULTS
  The correlation between the CT volume and the volume measured by the circumference was high and significant. There was no correlation between the limb volume and the bare body weight, BMI or IBW. The correlation between the no-fat CT volume and IBW-corrected limb volume was high and significant.
  
  
  CONCLUSIONS
  An appropriate drug dosing in ILP can be achieved by combining the limb volume with the simple circumference measurements and the IBW to body-weight ratio.
authors.affiliation: Department of Trauma Surgery and Musculoskeletal Surgical Oncology, University Hospital of Essen and Sarcoma Center at the West German Cancer Center (WTZ), University of Duisburg-Essen, Hufelandstr, 55, D-45122 Essen, Germany. lars.podleska@uk-essen.de.
authors.forename: Lars Erik
authors.initials: LE
authors.lastname: Podleska
authors.forename: Thorsten
authors.initials: T
authors.lastname: Poeppel
authors.forename: Michael
authors.initials: M
authors.lastname: Herbrik
authors.forename: Lisa
authors.initials: L
authors.lastname: Dahlkamp
authors.forename: Florian
authors.initials: F
authors.lastname: Grabellus
authors.forename: Georg
authors.initials: G
authors.lastname: Taeger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015992:Body Mass Index; D001835:Body Weight; D010478:Chemotherapy, Cancer, Regional Perfusion; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D035002:Lower Extremity / Q000473:pathology*; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents