title: Functional core/shell drug nanoparticles for highly effective synergistic cancer therapy.
abstract: Gold (Au)-nanoshelled 10-hydroxycamptothecin nanoparticles (HCPT NPs) are developed with combination of photothermal therapy and chemotherapy for highly effective cancer therapy. The strong near-infrared (NIR) absorbance from Au nanoshells endows the nanocomposites photothermal effects and on-demand drug release. Notably, the drug-loading content reaches up to 63.7 wt%, which is much higher than that in the previously reported nanovehicles systems. Both in vitro and in vivo studies indicate that the combined local specific chemotherapy with external NIR photothermal therapy demonstrates a synergistic effect, which is significantly better than either of them alone. More importantly, due to the high drug-loading content and efficient photothermal effects of the nanocomposites, 100% in vivo tumor elimination is achieved at a low laser irradiation power density of 1 W cm(-) (2) without weight loss and tumor recurrence. No obvious systematic toxicity is observed for the injected mice, indicating the good biocompatibility of this kind of multifunctional drug nanocomposites. This work highlights the great potential of drug-nanostructure-based multifunctional core/shell nanpocomposite for highly efficient cancer therapy.
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou, Nano Science and Technology, Jiangsu Key Laboratory for Carbon-Based Functional Materials, Soochow University, Suzhou Jiangsu, 215123, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Mengjiao
authors.initials: M
authors.lastname: Zhou
authors.forename: Baishun
authors.initials: B
authors.lastname: Tian
authors.forename: Caitong
authors.initials: C
authors.lastname: Yu
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Jie
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Hao
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D005260:Female; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D053685:Laser Therapy; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000628:therapy; D014018:Tissue Distribution; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D006046:Gold; C028098:10-hydroxycamptothecin; D002166:Camptothecin
keywords: core-shell drug nanoparticles; photothermal therapy; synergistic effects