title: Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes.
abstract: The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropylphenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coli. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3.
authors.affiliation: INQUISUR, Departamento de Química, Universidad Nacional del Sur, Av. Alem 1253, B8000CPB Bahía Blanca, Argentina.
authors.forename: Gabriela A
authors.initials: GA
authors.lastname: Fernández
authors.affiliation: INQUISUR, Departamento de Química, Universidad Nacional del Sur, Av. Alem 1253, B8000CPB Bahía Blanca, Argentina. Electronic address: svela@uns.edu.ar.
authors.forename: María S
authors.initials: MS
authors.lastname: Vela Gurovic
authors.affiliation: CENPAT, Bvd. Brown 2915, U9120ACD Puerto Madryn, Argentina.
authors.forename: Nelda L
authors.initials: NL
authors.lastname: Olivera
authors.affiliation: INQUISUR, Departamento de Química, Universidad Nacional del Sur, Av. Alem 1253, B8000CPB Bahía Blanca, Argentina.
authors.forename: Alicia B
authors.initials: AB
authors.lastname: Chopa
authors.affiliation: INQUISUR, Departamento de Química, Universidad Nacional del Sur, Av. Alem 1253, B8000CPB Bahía Blanca, Argentina. Electronic address: gsilbestri@uns.edu.ar.
authors.forename: Gustavo F
authors.initials: GF
authors.lastname: Silbestri
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006046:Gold / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects; D044124:Yersinia ruckeri / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D006571:Heterocyclic Compounds; C030011:carbene; D006046:Gold; D008697:Methane
keywords: Antibacterial; N-heterocyclic carbene; Water-soluble Au(I)