title: Effects of zoledronic acid on physiologic bone remodeling of condylar part of TMJ: a radiologic and histomorphometric examination in rabbits.
abstract: OBJECTIVE
  The purpose of the present study is to evaluate the effects of systemically administered zoledronic acid (ZA) on the physiological bone remodeling and the microarchitectural parameters of the condylar part of TMJ in a rabbit model.
  
  
  METHODS
  Thirty skeletally mature male New Zealand white rabbits were randomly divided into two groups. The experimental group was administered an intravenous, single dose of 0.1 mg/kg ZA diluted with 15 mL of saline in a 15-minute perfusion with an infusion pump. The control group was administered only saline infusion for 15 minutes. All rabbits were sacrificed on the 21st postoperative day. Radiodensitometric and histomorphometric examinations were performed on the harvested mandibular condyles. The data were analyzed statistically.
  
  
  RESULTS
  Radiodensitometric findings showed that ZA treatment resulted in a significant increase in the mineralization of mandibular condyle. This result was supported by the histomorphometric findings.
  
  
  CONCLUSIONS
  The present study has revealed that a temporary delay in the physiological bone remodeling using single dose of ZA increases bone mineral content and makes the microarchitecture of the mandibular condyle more compact. These effects may be regarded as base data and considered in numerous clinical situations including TMJ.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Saricam-Balcali, 01330 Adana, Turkey.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Tatli
authors.affiliation: Private Practice in Oral and Maxillofacial Surgery, 01120 Adana, Turkey.
authors.forename: Yakup
authors.initials: Y
authors.lastname: Ustün
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Saricam-Balcali, 01330 Adana, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kürkçü
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Saricam-Balcali, 01330 Adana, Turkey.
authors.forename: Mehmet Emre
authors.initials: ME
authors.lastname: Benlidayı
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects*; D004164:Diphosphonates / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D011859:Radiography; D013704:Temporomandibular Joint / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects*; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid