title: Luteinizing hormone and follicle stimulating hormone synergy: A review of role in controlled ovarian hyper-stimulation.
abstract: Luteinizing hormone (LH) in synergy with follicle stimulating hormone (FSH) stimulates normal follicular growth and ovulation. FSH is frequently used in assisted reproductive technology (ART). Recent studies have facilitated better understanding on the complementary role of the LH to FSH in regulation of the follicle; however, role of LH in stimulation of follicle, optimal dosage of LH in stimulation and its importance in advanced aged patients has been a topic of discussion among medical fraternity. Though the administration of exogenous LH with FSH is obligatory for controlled ovarian stimulation in patients with hypogonadotropic hypogonadism, there is still a paucity of information of its usage in other patient population. In this review we looked in to the multiple roles that LH plays complementary to FSH to better understand the LH requirement in patients undergoing ART.
authors.affiliation: Division of Gynaecology, Krishna IVF Clinic, Visakhapatnam, India.
authors.forename: Gottumukkala Achyuta Rama
authors.initials: GA
authors.lastname: Raju
authors.affiliation: Department of Pharmacology Medical Affairs, Merck Specialities Private Limited, Mumbai, Maharashtra, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Chavan
authors.affiliation: Department of Reproductive medicine, Infertility Institute and Research Centre, Secunderabad, Andhra Pradesh, India.
authors.forename: Mamata
authors.initials: M
authors.lastname: Deenadayal
authors.affiliation: Department of Obstetrics, Gynaecology & Infertility, Gunasheela Assisted Reproduction Centre, Bengaluru, Karnataka, India.
authors.forename: Devika
authors.initials: D
authors.lastname: Gunasheela
authors.affiliation: Department of Reproductive Medicine, NOVA IVI Fertility, Kolkata, West Bengal, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Gutgutia
authors.affiliation: Department of Reproductive Medicine, Prashanth Fertility Research Centre, Chennai, India.
authors.forename: Geetha
authors.initials: G
authors.lastname: Haripriya
authors.affiliation: Department of Obstetrics, Gynaecology & Reproductive Medicine, Womens Center and Hospitals, Coimbatore, Tamil Nadu, India.
authors.forename: Mirudhubashini
authors.initials: M
authors.lastname: Govindarajan
authors.affiliation: Department of Infertility, Akanksha IVF, Anand, Gujarat, India.
authors.forename: Nayana Hitesh
authors.initials: NH
authors.lastname: Patel
authors.affiliation: Department of Assisted Reproduction, Fertility Associates, Mumbai, Maharashtra, India.
authors.forename: Ameet Shashikant
authors.initials: AS
authors.lastname: Patki
keywords: Assisted reproductive techniques; follicle stimulating hormone; luteinizing hormone; ovarian hyper-stimulation