title: Are baseline high molecular weight adiponectin levels associated with radiographic progression in rheumatoid arthritis and osteoarthritis?
abstract: OBJECTIVE
  To investigate whether high molecular weight adiponectin (hmwAPN) mediates the associations of total adiponectin (totAPN) with radiographic progression in rheumatoid arthritis (RA) and hand osteoarthritis (HOA).
  
  
  METHODS
  Associations between baseline hmwAPN or totAPN levels with radiographic progression were determined using multivariate linear regression or generalized estimated equations.
  
  
  RESULTS
  In patients with RA, totAPN associated positively, whereas in patients with HOA it associated negatively with radiographic progression. In contrast, hmwAPN did not associate significantly with radiographic progression in either cohort.
  
  
  CONCLUSIONS
  Our data indicate that the differential effects associated between totAPN and radiographic progression in either RA or HOA are not mediated by hmwAPN.
authors.affiliation: From the Department of Rheumatology, and the Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
authors.forename: Inge R
authors.initials: IR
authors.lastname: Klein-Wieringa
authors.forename: Stefan N
authors.initials: SN
authors.lastname: Andersen
authors.forename: Linda
authors.initials: L
authors.lastname: Herb-van Toorn
authors.forename: Joanneke C
authors.initials: JC
authors.lastname: Kwekkeboom
authors.forename: Anette H M
authors.initials: AH
authors.lastname: van der Helm-van Mil
authors.forename: Ingrid
authors.initials: I
authors.lastname: Meulenbelt
authors.forename: Tom W J
authors.initials: TW
authors.lastname: Huizinga
authors.forename: Margreet
authors.initials: M
authors.lastname: Kloppenburg
authors.forename: René E M
authors.initials: RE
authors.lastname: Toes
authors.forename: Andreea
authors.initials: A
authors.lastname: Ioan-Facsinay
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000000981:diagnostic imaging*; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D005260:Female; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D015999:Multivariate Analysis; D010003:Osteoarthritis / Q000097:blood* / Q000000981:diagnostic imaging*; D011859:Radiography
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers
keywords: HAND OSTEOARTHRITIS; HIGH MOLECULAR WEIGHT ADIPONECTIN; RADIOGRAPHIC PROGRESSION; RHEUMATOID ARTHRITIS; TOTAL ADIPONECTIN