title: Synthesis of a multibranched porphyrin-oligonucleotide scaffold for the construction of DNA-based nano-architectures.
abstract: The interest in the functionalization of oligonucleotides with organic molecules has grown considerably over the last decade. In this work, we report on the synthesis and characterization of porphyrin-oligonucleotide hybrids containing one to four DNA strands (P1-P4). The hybrid P4, which inserts one porphyrin and four DNA fragments, was combined with gold nanoparticles and imaged by transmission electron microscopy.
authors.affiliation: CEA Saclay, IRAMIS, NIMBE, Laboratoire d'Innovation en Chimie des Surfaces et Nanosciences (LICSEN), F-91191 Gif sur Yvette, France. stephane.campidelli@cea.fr.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Clavé
authors.forename: Grégory
authors.initials: G
authors.lastname: Chatelain
authors.forename: Arianna
authors.initials: A
authors.lastname: Filoramo
authors.forename: Didier
authors.initials: D
authors.lastname: Gasparutto
authors.forename: Christine
authors.initials: C
authors.lastname: Saint-Pierre
authors.forename: Eric
authors.initials: E
authors.lastname: Le Cam
authors.forename: Olivier
authors.initials: O
authors.lastname: Piétrement
authors.forename: Vincent
authors.initials: V
authors.lastname: Guérineau
authors.forename: Stéphane
authors.initials: S
authors.lastname: Campidelli
mesh_terms: D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D009841:Oligonucleotides / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D009841:Oligonucleotides; D011166:Porphyrins; D006046:Gold; D004247:DNA