title: A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin.
abstract: A 15-step synthesis of the iGluR antagonist kaitocephalin from aspartic acid is reported. The linchpin pyrrolidine ring of the target molecule is efficiently assembled with in a single operation via an asymmetric [C+NC+CC] reaction.
authors.affiliation: Department of Chemistry, Washington State University, Pullman, WA 99164-4630, USA. ppg@wsu.edu.
authors.forename: Philip
authors.initials: P
authors.lastname: Garner
authors.forename: Laksiri
authors.initials: L
authors.lastname: Weerasinghe
authors.forename: Ian
authors.initials: I
authors.lastname: Van Houten
authors.forename: Jieyu
authors.initials: J
authors.lastname: Hu
mesh_terms: D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D055324:Eupenicillium / Q000737:chemistry / Q000378:metabolism; D009584:Nitrogen / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry; D058468:Receptors, Ionotropic Glutamate / Q000037:antagonists & inhibitors / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D011758:Pyrroles; D011759:Pyrrolidines; D058468:Receptors, Ionotropic Glutamate; D002244:Carbon; C442421:kaitocephalin; C032519:pyrrolidine; D009584:Nitrogen