title: β-Cyclodextrin assisted solubilization of Cu and Cr complexes of flavonoids in aqueous medium: a DNA-interaction study.
abstract: Cu and Cr complexes of three flavonoids (morin, quercetin and 6-hydroxyflavone) were synthesized and included in beta-cyclodextrin (βCD) with the objective of improving their pharmacokinetic profiles. Then binding with ds.DNA was studied to monitor their interactive tendencies at physiological conditions. The binding constants and other thermodynamic data from UV-vis spectroscopy and cyclic voltammetry revealed Cr-flavonoid-βCD to interact with ds.DNA at pH-7.4 through electrostatic mode of binding while Cu-flavonoid-βCD can intercalate into DNA. The strong binding propensity of Cu-flavonoid-βCD with ds.DNA encourages their application as anticancerous agent.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Erum
authors.initials: E
authors.lastname: Jabeen
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address: nkausarjanjua@yahoo.com.
authors.forename: Naveed Kausar
authors.initials: NK
authors.lastname: Janjua
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Shahid
authors.initials: S
authors.lastname: Hameed
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D002857:Chromium / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids; D047392:beta-Cyclodextrins; D002857:Chromium; D003300:Copper; D004247:DNA
keywords: DNA interactional study; Flavonoid–metal complexes; β-Cyclodextrin mediation