title: Strategy for modeling flow diverters in cerebral aneurysms as a porous medium.
abstract: Simulations using the patient-specific geometry of the aneurysm may help in a better planning of the treatment and in a consequent reduction of the associated risks. We propose, evaluate, and implement a methodology for the simulation of flow diverter (FD) devices in intracranial aneurysms by using a porous medium method (PMM), which greatly reduces the computational cost of these simulations compared with immersed method (IMM) approaches used to model complex FDs. The method relies on parameters from an empirical correlation derived from experimental observations in wire screens, consistent with CFD simulations. The verification of our PMM strategy was carried out by comparing the results of simulations in different (patient-specific) geometries and FDs, to those obtained under identical conditions by the IMM. Overall, both quantitative and qualitative results are consistent between IMM and PMM in cases where the local porosity remains roughly uniform throughout the neck, with differences in the reduction of the observables lower than 10%. This PMM strategy is up to 10 times faster than the IMM, which allows for a runtime of hours instead of days, bringing it closer for its application in the clinic.
authors.affiliation: Center for CFD, George Mason University, Farifax, VA 22030, U.S.A.
authors.forename: M
authors.initials: M
authors.lastname: Raschi
authors.forename: F
authors.initials: F
authors.lastname: Mut
authors.forename: R
authors.initials: R
authors.lastname: Löhner
authors.forename: J R
authors.initials: JR
authors.lastname: Cebral
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D001807:Blood Vessel Prosthesis; D003198:Computer Simulation; D004867:Equipment Design; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology / Q000628:therapy*; D008962:Models, Theoretical; D016062:Porosity
keywords: CFD; aneurysm; flow diverter; modeling; porous medium