title: Potential role of IGF-1 z score to predict permanent linear growth impairment in children with IBD.
abstract: In this pilot study, we analyzed serum insulin-like growth factor 1 (IGF-1)- and IGF-binding protein-3-for-age z scores from 54 inflammatory bowel disease children with no, temporary, or permanent growth impairment. Although our findings did not reach statistical significance, patients with permanent linear growth impairment had lower IGF-1-for-age z scores (-1.76 [-2.25 to -0.43]) compared with those with no or temporary growth impairment (-0.84 [-1.49 to -0.3]) and -1.16 [-1.59 to -1.51], respectively). IGF-binding protein-3 levels were similar across the 3 groups. In the absence of significant inflammation and malnutrition, lower IGF-1-for-age z scores may help distinguish patients likely to have permanent growth impairment from those whose growth impairment is likely to be temporary.
authors.affiliation: *Division of Gastroenterology and Nutrition †Clinical Research Center, Design and Analysis Core ‡Division of Endocrinology, Boston Children's Hospital, Boston, MA.
authors.forename: Jessica J
authors.initials: JJ
authors.lastname: Lee
authors.forename: Paul D
authors.initials: PD
authors.lastname: Mitchell
authors.forename: Helen C
authors.initials: HC
authors.lastname: Hood
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Grand
authors.forename: Laurie E
authors.initials: LE
authors.lastname: Cohen
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000367:Age Factors; D001799:Blood Sedimentation; D015992:Body Mass Index; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002657:Child Development / Q000502:physiology*; D005260:Female; D006130:Growth Disorders / Q000097:blood* / Q000209:etiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D015596:Nutrition Assessment; D010865:Pilot Projects; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000305:Adrenal Cortex Hormones; C583557:IGF1 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D015850:Interleukin-6; D012709:Serum Albumin; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein