title: [Neuroendocrine neoplasms of the distal jejunum and ileum].
abstract: Neuroendocrine neoplasms (NEN) of the distal jejunum and ileum derive from serotonin-producing enterochromaffin (EC) cells. Due to their low proliferation rate and their infiltrative growth, they are often discovered at an advanced disease stage when metastasis has already occurred. The biology of these tumours is different from other NEN of the digestive tract. In order to standardise and improve diagnosis and therapy, the guidelines for the diagnosis and clinical management of jejuno-ileal NEN as well as for the management of patients with liver and other distant metastases from NEN were revised by the European Neuroendocrine Tumour Society (ENETS) in 2012. This review focuses on aspects relevant for surgical pathology.
authors.affiliation: Institut für Pathologie, Sektion für Neuroendokrine Neoplasien, Endokrines Tumorzentrum und Deutsches NET-Register, Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland, anlauf@patho-limburg.de.
authors.forename: M
authors.initials: M
authors.lastname: Anlauf
authors.forename: B
authors.initials: B
authors.lastname: Sipos
authors.forename: I
authors.initials: I
authors.lastname: Boeck
authors.forename: S E
authors.initials: SE
authors.lastname: Baldus
authors.forename: S
authors.initials: S
authors.lastname: Heikaus
authors.forename: M
authors.initials: M
authors.lastname: Krausch
authors.forename: W T
authors.initials: WT
authors.lastname: Knoefel
authors.forename: N
authors.initials: N
authors.lastname: Begum
authors.forename: P
authors.initials: P
authors.lastname: Goretzki
authors.forename: M
authors.initials: M
authors.lastname: Schott
authors.forename: C J
authors.initials: CJ
authors.lastname: Auernhammer
authors.forename: B
authors.initials: B
authors.lastname: Cremer
authors.forename: A
authors.initials: A
authors.lastname: Rinke
authors.forename: S
authors.initials: S
authors.lastname: Ezziddin
authors.forename: C
authors.initials: C
authors.lastname: Fottner
authors.forename: G
authors.initials: G
authors.lastname: Pöpperl
authors.forename: H
authors.initials: H
authors.lastname: Lahner
authors.forename: D
authors.initials: D
authors.lastname: Hörsch
authors.forename: H E
authors.initials: HE
authors.lastname: Gabbert
authors.forename: P
authors.initials: P
authors.lastname: Komminoth
authors.forename: A
authors.initials: A
authors.lastname: Perren
authors.forename: G
authors.initials: G
authors.lastname: Klöppel
authors.forename: B
authors.initials: B
authors.lastname: Wiedenmann
authors.forename: M
authors.initials: M
authors.lastname: Pavel
authors.forename: U
authors.initials: U
authors.lastname: Pape
mesh_terms: D049109:Cell Proliferation; D003937:Diagnosis, Differential; D018450:Disease Progression; D004759:Enterochromaffin Cells / Q000473:pathology; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology* / Q000601:surgery; D007082:Ileum / Q000473:pathology / Q000601:surgery; D007580:Jejunal Neoplasms / Q000473:pathology* / Q000601:surgery; D007583:Jejunum / Q000473:pathology / Q000601:surgery; D018358:Neuroendocrine Tumors / Q000473:pathology* / Q000601:surgery; D017410:Practice Guidelines as Topic; D017481:Receptors, Somatostatin / Q000032:analysis
chemical_list: D017481:Receptors, Somatostatin