title: Transient diabetes insipidus in a preterm neonate and the challenge of desmopressin dosing.
abstract: BACKGROUND
  As neonatal central diabetes insipidus is rare in preterm neonates with intraventricular hemorrhage (IVH), very little is known about dosing and the route of administration of desmopressin treatment.
  
  
  METHODS
  We present a preterm neonate born at 29 weeks' gestation. Within 24 h, she developed bilateral IVH with subsequent post-hemorrhagic hydrocephalus. On the 3rd postnatal day, she developed diabetes insipidus for which she was intranasally administered 0.2 mg desmopressin. This resulted in oliguria with several hours of anuria and a 25-point drop in sodium levels within 15 h.
  
  
  CONCLUSIONS
  The determination of the desmopressin dose in a preterm neonate is a challenge and there is no consistent literature about the dosing or the route of administration. We suggest starting with a low dose of intranasal desmopressin (0.05-0.1 μg) and titrate in accordance with clinical and laboratory parameters.
authors.forename: Danielle C M
authors.initials: DC
authors.lastname: Van der Kaay
authors.forename: Willemijn J M
authors.initials: WJ
authors.lastname: Van Heel
authors.forename: Jeroen
authors.initials: J
authors.lastname: Dudink
authors.forename: Erica L T
authors.initials: EL
authors.lastname: van den Akker
mesh_terms: D000281:Administration, Intranasal; D002543:Cerebral Hemorrhage / Q000150:complications / Q000188:drug therapy*; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage*; D003919:Diabetes Insipidus / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy*
chemical_list: D003894:Deamino Arginine Vasopressin