title: Association study of newly identified age-related macular degeneration susceptible loci SOD2, MBP, and C8orf42 in Han Chinese population.
abstract: A recent genome-wide association study has reported three newly identified susceptible loci (rs2842992 near the gene SOD2, rs1789110 near the gene MBP and rs722782 near the gene C8orf42) to be associated with the geographic atrophy subtype of age-related macular degeneration in European-descent population. We investigated the correlation between these variants and advanced age-related macular degeneration for the first time in a Han Chinese cohort; however, no evidence supports these previously identified loci contribute to advanced age-related macular degeneration susceptibility in Chinese population.
authors.forename: Mengyuan
authors.initials: M
authors.lastname: Kan
authors.forename: Fatao
authors.initials: F
authors.lastname: Liu
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Weng
authors.forename: Junyi
authors.initials: J
authors.lastname: Ye
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.forename: Mingqing
authors.initials: M
authors.lastname: Xu
authors.affiliation: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, P, R, China. helin@bio-x.cn.
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D008297:Male; D004676:Myelin Basic Protein / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013482:Superoxide Dismutase / Q000235:genetics*; D000099156:Superoxide Dismutase 2
chemical_list: D004676:Myelin Basic Protein; D009687:Nuclear Proteins; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2; C499048:MBP protein, human; C548804:TDRP protein, human