title: Ivorenolide B, an immunosuppressive 17-membered macrolide from Khaya ivorensis: structural determination and total synthesis.
abstract: Ivorenolide B (1), an unprecedented 17-membered macrolide featuring conjugated acetylenic bonds and four chiral centers, was isolated from Khaya ivorensis. The structure of 1 was fully determined by spectroscopic analysis and total syntheses of its four most possible stereoisomers. Compound 1 showed significant immunosuppressive activity.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.forename: Qun-Fang
authors.initials: QF
authors.lastname: Liu
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Xue
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Huang-Chao
authors.initials: HC
authors.lastname: Yu
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Yang
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Zuo
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: D007166:Immunosuppressive Agents; D018942:Macrolides; C000588843:ivorenolide B