title: The efficacy of nebulized salbutamol, magnesium sulfate, and salbutamol/magnesium sulfate combination in moderate bronchiolitis.
abstract: The aim of this paper is to compare the effect of nebulized magnesium sulfate to nebulized salbutamol and salbutamol/magnesium sulfate on successful discharge from the emergency department. A total of 56 infants were included in this double-blinded, prospective study. Infants were grouped according to the nebulized treatment they received: group 1-salbutamol/normal saline, group 2-magnesium sulfate and normal saline, and group 3-salbutamol plus magnesium sulfate. Heart beat, bronchiolitis, clinical severity scores (CSS), and oxygen saturation of the patients were determined before and after nebulization (0, 1, 4 h). The patients were monitored for adverse reactions. Post-treatment mean CSS results were significantly lower than pre-treatment scores in all groups at 4 h with no significant difference within groups. CSS scores were lower in the salbutamol/magnesium sulfate group when compared with the magnesium sulfate and salbutamol groups (3.4 (2.4-4.3), 4.7 (3.8-5.7), 4.0 (3.2-4.3)). CSS were significantly lower than those from the magnesium sulfate group.
  
  
  CONCLUSIONS
  Nebulized magnesium sulfate plus salbutamol may have additive effects for improving the short-term CSS.
authors.affiliation: Department of Pediatric Pulmonology, Erciyes University Faculty of Medicine, Pediatric Pulmonology Unit, Kayseri, 38000, Turkey, mhmtkose@yahoo.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kose
authors.forename: Mehmet Adnan
authors.initials: MA
authors.lastname: Ozturk
authors.forename: Hakan
authors.initials: H
authors.lastname: Poyrazoğlu
authors.forename: Tuba
authors.initials: T
authors.lastname: Elmas
authors.forename: Duygu
authors.initials: D
authors.lastname: Ekinci
authors.forename: Filiz
authors.initials: F
authors.lastname: Tubas
authors.forename: Tuba
authors.initials: T
authors.lastname: Kurt
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Goktas
mesh_terms: D000420:Albuterol / Q000008:administration & dosage*; D001988:Bronchiolitis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D009330:Nebulizers and Vaporizers; D014677:Pharmaceutical Vehicles; D011446:Prospective Studies; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D001993:Bronchodilator Agents; D014677:Pharmaceutical Vehicles; D012462:Saline Solution, Hypertonic; D008278:Magnesium Sulfate; D000420:Albuterol