title: PET and PET/CT with 68gallium-labeled somatostatin analogues in Non GEP-NETs Tumors.
abstract: Somatostatin (SST) is a 28-amino-acid cyclic neuropeptide mainly secreted by neurons and endocrine cells. A major interest for SST receptors (SSTR) as target for in vivo diagnostic and therapeutic purposes was born since a series of stable synthetic SST-analouges PET became available, being the native somatostatin non feasible for clinical use due to the very low metabolic stability. The rationale for the employment of SST-analogues to image cancer is both based on the expression of SSTR by tumor and on the high affinity of these compounds for SSTR. The primary indication of SST-analogues imaging is for neuroendocrine tumors (NETs), which usually express a high density of SSTR, so they can be effectively targeted and visualized with radiolabeled SST-analogues in vivo. Particularly, SST-analogues imaging has been widely employed in gastroenteropancreatic (GEP) NETs. Nevertheless, a variety of tumors other than NETs expresses SSTR thus SST-analogues imaging can also be used in these tumors, particularly if treatment with radiolabeled therapeutic SST-analouges PET is being considered. The aim of this paper is to provide a concise overview of the role of positron emission tomography/computed tomography (PET/CT) with (68)Ga-radiolabeled SST-analouges PET in tumors other than GEP-NETs.
authors.affiliation: Nuclear Medicine Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, 42123 Reggio Emilia, Italy.
authors.forename: Martina
authors.identifier: 0000-0003-2214-6492
authors.initials: M
authors.lastname: Sollini
authors.affiliation: Regional Center of Nuclear Medicine, University of Pisa, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, 56125 Pisa, Italy.
authors.forename: Paola Anna
authors.initials: PA
authors.lastname: Erba
authors.affiliation: Nuclear Medicine Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, 42123 Reggio Emilia, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fraternali
authors.affiliation: Nuclear Medicine Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, 42123 Reggio Emilia, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Casali
authors.affiliation: Nuclear Medicine Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, 42123 Reggio Emilia, Italy.
authors.forename: Maria Liberata
authors.initials: ML
authors.lastname: Di Paolo
authors.affiliation: Nuclear Medicine Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, 42123 Reggio Emilia, Italy.
authors.forename: Armando
authors.initials: A
authors.lastname: Froio
authors.affiliation: Endocrinology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, 42123 Reggio Emilia, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Frasoldati
authors.affiliation: Nuclear Medicine Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, 42123 Reggio Emilia, Italy.
authors.forename: Annibale
authors.initials: A
authors.lastname: Versari
mesh_terms: D002276:Carcinoid Tumor / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary*; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D064847:Multimodal Imaging / Q000379:methods; D015282:Octreotide / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D015282:Octreotide