title: The presence of metastases in regional lymph nodes is associated with tumor size and depth of invasion in sporadic gastric adenocarcinoma.
abstract: BACKGROUND
  Gastric adenocarcinoma is more often found in men over 50 years in the form of an antral lesion. The tumor has heterogeneous histopathologic features and a poor prognosis (median survival of 15% in five years).
  
  
  OBJECTIVE
  To estimate the relationship between the presence of nodal metastasis and other prognostic factors in sporadic gastric adenocarcinoma.
  
  
  METHODS
  Were evaluated 164 consecutive cases of gastric adenocarcinoma previously undergone gastrectomy (partial or total), without clinical evidence of distant metastasis, and determined the following variables: topography of the lesion, tumor size, Borrmann macroscopic configuration, histological grade, early or advanced lesions, Lauren histological subtype, presence of signet ring cell, degree of invasion, perigastric lymph node status, angiolymphatic/perineural invasion, and staging.
  
  
  RESULTS
  Were found 21 early lesions (12.8%) and 143 advanced lesions (87.2%), with a predominance of lesions classified as T3 (n=99/60, 4%) and N1 (n=62/37, 8%). The nodal status was associated with depth of invasion (p<0.001) and tumor size (p<0.001). The staging was related to age (p=0.048), histological grade (p=0.003), and presence of signet ring cells (p = 0.007), angiolymphatic invasion (p = 0.001), and perineural invasion (p=0.003).
  
  
  CONCLUSIONS
  In gastric cancer, lymph node involvement, tumor size and depth of invasion are histopathological data associated with the pattern of growth/tumor spread, suggesting that a wide dissection of perigastric lymph nodes is a fundamental step in the surgical treatment of these patients.
authors.affiliation: Porto Alegre Conceicao Hospital, Porto Alegre, RS, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Cambruzzi
authors.affiliation: Porto Alegre Conceicao Hospital, Porto Alegre, RS, Brazil.
authors.forename: Andreza Mariane de
authors.initials: AM
authors.lastname: Azeredo
authors.affiliation: Porto Alegre Conceicao Hospital, Porto Alegre, RS, Brazil.
authors.forename: Ardala
authors.initials: A
authors.lastname: Kronhart
authors.affiliation: Porto Alegre Conceicao Hospital, Porto Alegre, RS, Brazil.
authors.forename: Katia Martins
authors.initials: KM
authors.lastname: Foltz
authors.affiliation: Porto Alegre Conceicao Hospital, Porto Alegre, RS, Brazil.
authors.forename: Claudio Galeano
authors.initials: CG
authors.lastname: Zettler
authors.affiliation: Porto Alegre Conceicao Hospital, Porto Alegre, RS, Brazil.
authors.forename: Karla Lais
authors.initials: KL
authors.lastname: Pêgas
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary*; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology*; D047368:Tumor Burden