title: Oral pyogenic granuloma in hemophilia: a report of 2 cases.
abstract: Pyogenic granulomas (PGs) are benign vascular lesions occurring in skin and mucous membranes, often secondary to trauma or chronic inflammation. Oral PGs have never been described previously in hemophilia. We describe 2 pediatric patients with hemophilia A, who developed PGs with inadequate factor therapy for bleeding. PG pathophysiology suggests an association with hemophilia given chronic vascular damage and low-grade inflammation at sites of bleeding in hemophilia patients. Knowledge about the occurrence of PGs in hemophilia patients is essential for prompt diagnosis and early institution of factor therapy, which in turn allows more rapid cessation of bleeding and lesion involution.
authors.affiliation: *Fellow in Pediatric Hematology and Oncology †Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX.
authors.forename: Holly
authors.initials: H
authors.lastname: Lindsay
authors.forename: Lakshmi V
authors.initials: LV
authors.lastname: Srivaths
mesh_terms: D002675:Child, Preschool; D003029:Coagulants / Q000627:therapeutic use*; D005169:Factor VIII / Q000627:therapeutic use*; D017789:Granuloma, Pyogenic / Q000175:diagnosis* / Q000209:etiology; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009059:Mouth Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D011379:Prognosis
chemical_list: D003029:Coagulants; D005169:Factor VIII