title: Insulin infusion therapy in critically ill patients.
abstract: While dysglycemia (hyperglycemia, hypoglycemia and glucose variability) is clearly associated with increased mortality in critically ill patients, target range of blood glucose control remains controversial. Standardized insulin infusion protocols constitute the basis of treatment of these patients. The choice of protocol and its implementation is a great challenge. In this article, we review the published data to help define the essential elements that compose a good protocol and apply the right conditions to make it safe and effective.
authors.affiliation: Département de Médecine, Service d'endocrinologie, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada. Electronic address: jm.boutin@umontreal.ca.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Boutin
authors.affiliation: Département de Pharmacie, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
authors.forename: Lyne
authors.initials: L
authors.lastname: Gauthier
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D002985:Clinical Protocols; D003422:Critical Care; D016638:Critical Illness; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D007003:Hypoglycemia / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage*; D017410:Practice Guidelines as Topic
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; C517652:hemoglobin A1c protein, human
keywords: computer-base protocol; critical care; hyperglycemia; hyperglycémie; intravenous insulin protocol; protocole d'insuline par voie intraveineuse; protocole informatisé; soins aux patients gravement atteints