title: Effect of age and calorie restriction on corpus callosal integrity in rhesus macaques: a fiber tractography study.
abstract: The rhesus macaque exhibits age-related brain changes similar to humans, making an excellent model of normal aging. Calorie restriction is a dietary intervention that reduces age-related comorbidities in short-lived animals, and its effects are still under study in rhesus macaques. Here, using deterministic fiber tracking method, we examined the effects of age and calorie restriction on a diffusion tensor imaging measure of white matter integrity, fractional anisotropy (FA), within white matter tracks traversing the anterior (genu) and posterior (splenium) corpus callosum in rhesus monkeys. Our results show: (1) a significant inverse relationship between age and mean FA of tracks traversing the genu and splenium; (2) higher mean FA of the splenium tracks as compared to that of genu tracks across groups; and (3) no significant diet effect on mean track FA through either location. These results are congruent with the age-related decline in white matter integrity reported in humans and monkeys, and the anterior-to-posterior gradient in white matter vulnerability to normal aging in humans. Further studies are warranted to critically evaluate the effect of calorie restriction on brain aging in this unique cohort of elderly primates.
authors.affiliation: Neuroscience Training Program, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA; Medical Scientist Training Program, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705, USA.
authors.forename: Aadhavi
authors.initials: A
authors.lastname: Sridharan
authors.affiliation: Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; Department of Medicine, University of Wisconsin-Madison, 2500 Overlook Terrace, Madison, WI 53705, USA.
authors.forename: Barbara B
authors.initials: BB
authors.lastname: Bendlin
authors.affiliation: Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA; Department of Neurology, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 52706, USA.
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Gallagher
authors.affiliation: Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; Department of Medicine, University of Wisconsin-Madison, 2500 Overlook Terrace, Madison, WI 53705, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Oh
authors.affiliation: Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; Department of Medicine, University of Wisconsin-Madison, 2500 Overlook Terrace, Madison, WI 53705, USA.
authors.forename: Auriel A
authors.initials: AA
authors.lastname: Willette
authors.affiliation: Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, WI 53705, USA.
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Alexander
authors.affiliation: Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA; Institute for Clinical and Translational Research, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705, USA.
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Kemnitz
authors.affiliation: Wisconsin National Primate Research Center, 1220 Capitol Court, Madison, WI 53705, USA.
authors.forename: Ricki J
authors.initials: RJ
authors.lastname: Colman
authors.affiliation: Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA.
authors.forename: Richard H
authors.initials: RH
authors.lastname: Weindruch
authors.affiliation: Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; Department of Medicine, University of Wisconsin-Madison, 2500 Overlook Terrace, Madison, WI 53705, USA.
authors.forename: Sterling C
authors.initials: SC
authors.lastname: Johnson
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000818:Animals; D016880:Anisotropy; D031204:Caloric Restriction; D003337:Corpus Callosum / Q000502:physiology*; D038524:Diffusion Magnetic Resonance Imaging; D008253:Macaca mulatta; D009412:Nerve Fibers / Q000502:physiology*
keywords: Aging; Corpus callosum; Diffusion tensor imaging; Macaque; Tractography