title: Role of high mobility group box 1 and its signaling pathways in renal diseases.
abstract: The high mobility group box 1 (HMGB1) protein, a member of the high mobility group nuclear protein family and an endogenous ligand for TLR2/4 and RAGE (receptor for advanced glycation end products), is one of the most evolutionarily conserved proteins and it has recently emerged as an extracellular signaling factor with key roles in cell differentiation, proliferation and disease pathogenesis. The present data indicate that HMGB1 is one of most important proinflammatory cytokines, and plays an important role in renal diseases. The literatures were searched extensively and this review was performed to sum up the role of HMGB1 in renal diseases.
authors.affiliation: Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , China.
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology*; D024243:HMGB1 Protein / Q000276:immunology*; D006801:Humans; D007668:Kidney / Q000276:immunology*; D007674:Kidney Diseases / Q000276:immunology*; D018448:Models, Immunological; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D016207:Cytokines; D024243:HMGB1 Protein
keywords: Acute kidney injury; HMGB1; chronic kidney disease; diabetic nephropathy; granulomatous nephritis; high mobility group box 1; signaling pathways