title: Evaluation of angiogenesis in non-small cell lung carcinoma by CD34 immunohistochemistry.
abstract: The objective of the study was to investigate angiogenesis in non-small lung cancer by measuring the expression of CD34. Immunohistochemistry was used to detect CD34 at the endothelial cell surface in 81 surgically resected non-small cell lung cancer specimens. CD34 immunohistochemistry had high specificity and sensitivity with minimal background, which enabled efficient identification of CD34-positive staining. Statistical analysis showed that increased microvessel density (MVD) was closely correlated to tumor progression as reflected by the clinical stage (P < 0.05). However, MVD was not significantly associated with lymph node metastasis and other clinical and pathological features (P > 0.05). In conclusion, microvascular density may play an important role in the development and progression of lung cancer.
authors.affiliation: Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Chongqing Medical University, Linjiang Road 74, Yuzhong District, Chongqing, 400010, China, drzhubing@tom.com.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Bing
authors.forename: Yang
authors.initials: Y
authors.lastname: Jian-ru
authors.forename: Jiang
authors.initials: J
authors.lastname: Yao-quan
authors.forename: Chen
authors.initials: C
authors.lastname: Shi-feng
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism*; D063646:Carcinogenesis; D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D055806:Microvessels / Q000378:metabolism; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism*
chemical_list: D018952:Antigens, CD34