title: Assessment of relapse in patients with peritoneal carcinomatosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy using F-18-FDG-PET/CT.
abstract: OBJECTIVE
  In patients with peritoneal carcinomatosis (PC), cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is an evolving therapeutic approach with curative intention. The differentiation between posttherapeutic findings after HIPEC and relapse of PC is challenging. We evaluated the diagnostic value of F-18-FDG-PET/CT in patients with relapse of PC after HIPEC.
  
  
  METHODS
  36 patients with recurring PC after HIPEC were examined on a whole-body PET/CT system (44 examinations). The examination included 3 D F-18-FDG-PET and contrast-enhanced CT. Images were assessed by two experienced readers regarding the presence and the extent of PC using the peritoneal carcinomatosis index (PCI). Imaging results were correlated with surgical findings or follow-up.
  
  
  RESULTS
  Relapse was suspected in 40 of 44 examinations. Relapse was missed by F-18-FDG PET/CT in 4 patients and significantly underestimated in 8 patients. The diagnostic accuracy for the detection of PC on a patient basis was 91 %, the sensitivity was 91 % and the positive predictive value was 100 %. The mean PCI was 11.4 ± 11.9 for PET/CT, 8.4 ± 10.3 for CT and 16.6 ± 15.0 in the case of surgical exploration. The extent of PC was underestimated by PET/CT and even more by CT alone (p < 0.05).
  
  
  CONCLUSIONS
  The diagnostic value of F-18-FDG PET/CT after cytoreductive surgery and HIPEC in the detection of recurring PC is superior to contrast-enhanced CT. However, the quantification of the extent of PC is limited due to post-therapeutic tissue alterations.
  
  
  CONCLUSIONS
  • Imaging of recurrent PC after HIPEC is challenging due to posttherapeutic tissue alterations.• The extent of recurrent PC after HIPEC is systematically underestimated by F-18-FDG PET/CT.• F-18-FDG PET/CT provides improved sensitivity for recurrent PC compared to contrast-enhanced CT.• The correlation of the extent of recurrent PC depicted by F-18-FDG PET/CT and surgical exploration is better than that of contrast-enhanced CT and surgical exploration.
authors.affiliation: Diagnostic and Interventional Radiology, Eberhard-Karls-University Tuebingen.
authors.forename: B
authors.initials: B
authors.lastname: Klumpp
authors.affiliation: Diagnostic and Interventional Radiology, Eberhard-Karls-University Tuebingen.
authors.forename: N F
authors.initials: NF
authors.lastname: Schwenzer
authors.affiliation: Diagnostic and Interventional Radiology, Eberhard-Karls-University Tuebingen.
authors.forename: S
authors.initials: S
authors.lastname: Gatidis
authors.affiliation: General, Visceral and Transplantation Surgery, Eberhard-Karls-University Tuebingen.
authors.forename: I
authors.initials: I
authors.lastname: Koenigsrainer
authors.affiliation: General, Visceral and Transplantation Surgery, Eberhard-Karls-University Tuebingen.
authors.forename: A
authors.initials: A
authors.lastname: Koenigsrainer
authors.affiliation: General, Visceral and Transplantation Surgery, Eberhard-Karls-University Tuebingen.
authors.forename: S
authors.initials: S
authors.lastname: Beckert
authors.affiliation: Nuclear Medicine, Eberhard-Karls-University Tuebingen.
authors.forename: M
authors.initials: M
authors.lastname: Mueller
authors.affiliation: Diagnostic and Interventional Radiology, Eberhard-Karls-University Tuebingen.
authors.forename: C D
authors.initials: CD
authors.lastname: Claussen
authors.affiliation: Diagnostic and Interventional Radiology, Eberhard-Karls-University Tuebingen.
authors.forename: C
authors.initials: C
authors.lastname: Pfannenberg
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant / Q000379:methods; D003131:Combined Modality Therapy; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000517:prevention & control; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012008:Recurrence; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18