title: Cardiovascular function alterations induced by acute paradoxical sleep deprivation in rats.
abstract: Sleep loss has been implicated in triggering the hypertension. The goal of the present study was investigated the possible mechanisms underlying cardiovascular alterations after acute paradoxical sleep deprivation (PSD). Male Wistar rats were assigned in two experimental groups: (1) control and (2) PSD for 24 h using the modified single platform method. Paradoxical sleep deprived rats exhibited higher blood pressure, heart rate (HR) and impaired baroreceptor sensitivity. After pharmacological autonomic double blockade (propranolol and methylatropine administration), intrinsic heart rate was decreased after PSD. The PSD rats showed a reduction in the vagal tone without affecting sympathetic tone. Isoproterenol administration (0.001, 0.01 and 1 µg/kg) induced an increase in ΔHR responses in PSD group. Electrocardiographic analysis in response to β-adrenergic stimulation indicated that PSD contributed to ventricular cardiac arrhythmias. Our findings suggest that acute paradoxical sleep loss induce cardiovascular alterations, autonomic imbalance accompanied by impaired baroreflex sensitivity and increased arrhythmia susceptibility.
authors.affiliation: Cardiovascular Division, Department of Physiology, Universidade Federal de São Paulo , SP , Brazil .
authors.forename: F R
authors.initials: FR
authors.lastname: Almeida
authors.forename: J C
authors.initials: JC
authors.lastname: Perry
authors.forename: H A
authors.initials: HA
authors.lastname: Futuro-Neto
authors.forename: V R
authors.initials: VR
authors.lastname: Almeida
authors.forename: R M
authors.initials: RM
authors.lastname: Sebastião
authors.forename: M L
authors.initials: ML
authors.lastname: Andersen
authors.forename: S
authors.initials: S
authors.lastname: Tufik
authors.forename: R R
authors.initials: RR
authors.lastname: Campos
authors.forename: C T
authors.initials: CT
authors.lastname: Bergamaschi
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology; D001342:Autonomic Nervous System Diseases / Q000209:etiology / Q000503:physiopathology; D017704:Baroreflex; D001794:Blood Pressure; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D007545:Isoproterenol / Q000008:administration & dosage; D008297:Male; D011311:Pressoreceptors / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation / Q000150:complications / Q000503:physiopathology*; D012895:Sleep, REM / Q000502:physiology
chemical_list: D007545:Isoproterenol
keywords: Arrhythmia; heart rate; isoproterenol; paradoxical sleep deprivation; sleep