title: The effect of intraoperative fluid volume administration on pancreatic fistulas after pancreaticoduodenectomy.
abstract: BACKGROUND
  Fluid therapy may be one of the most controversial topics in perioperative management. However, data concerning the influence of perioperative fluid administration on complications after pancreaticoduodenectomy are sparse.
  
  
  METHODS
  A group of 147 patients underwent pancreaticoduodenectomy for benign or malignant pathology of the pancreas or the periampullary region between 2005 and 2009. Clinical data, overall morbidity, and long-term outcomes were recorded.
  
  
  RESULTS
  We categorized the patients into two groups according to intraoperative fluid volume administration: a low fluid volume group (LFVG, <8.2 ml kg(-1) hr(-1), n = 90) group, and a high fluid volume group (HFVG, ≥8.2 ml kg(-1) hr(-1), n = 57). In terms of colloid administration, the high fluid volume group received significantly more colloid both during the intraoperative period and 0-12 hr after surgery (p < .001 and p < .007, respectively). Pancreatic fistula rates were significantly greater in the high fluid volume group (p = .035). However, the long-term survival rate was not different between the two groups.
  
  
  CONCLUSIONS
  High intraoperative fluid volume administration is associated with an increased incidence of pancreatic fistulas after pancreaticoduodenectomy.
authors.affiliation: Medical School of Nanjing University, Research Institute of General Surgery, Jinling Hospital Nanjing 210002 China.
authors.forename: Sizhen
authors.initials: S
authors.lastname: Wang
authors.forename: Xinbo
authors.initials: X
authors.lastname: Wang
authors.forename: Hongshan
authors.initials: H
authors.lastname: Dai
authors.forename: Jianming
authors.initials: J
authors.lastname: Han
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Jieshou
authors.initials: J
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality; D000328:Adult; D000368:Aged; D003102:Colloids / Q000008:administration & dosage; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010185:Pancreatic Fistula / Q000209:etiology*; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*; D019990:Perioperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies
chemical_list: D003102:Colloids