title: Multiple roles of Equarin during lens development.
abstract: Since the days of Hans Spemann, the ocular lens has served as one of the most important developmental systems for elucidating the fundamental processes of induction and differentiation. Lens is an important source of signals that influence the eye development and a variety of genes expressed by the lens have been identified. The identification of additional molecule(s), especially secreted ones that might mediate signals, will extend our knowledge of the molecular mechanisms of eye and lens development. Here, we will introduce a soluble molecule, Equarin, and discuss its vital role in multiple aspects of lens development.
authors.affiliation: Division of Developmental Neurobiology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Song
authors.forename: Hideaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Kunimasa
authors.initials: K
authors.lastname: Ohta
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology*; D002642:Chick Embryo; D018076:DNA, Complementary / Q000235:genetics; D016326:Extracellular Matrix Proteins; D005136:Eye Proteins / Q000235:genetics / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology*; D006023:Glycoproteins / Q000235:genetics; D036341:Intercellular Signaling Peptides and Proteins; D007908:Lens, Crystalline / Q000196:embryology* / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: D030161:Avian Proteins; C492631:CCDC80 protein, human; D018076:DNA, Complementary; D016326:Extracellular Matrix Proteins; D005136:Eye Proteins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D025521:Tumor Suppressor Proteins; D005346:Fibroblast Growth Factors
keywords: Equarin; development; fibroblast growth factors; lens