title: Hippocampal subfield volumes at 7T in early Alzheimer's disease and normal aging.
abstract: We compared hippocampal subfield and entorhinal cortex (ERC) volumes between patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls without cognitive impairment. Additionally, we investigated the relation between age and hippocampal subfields and ERC in controls. We performed ultra-high field 0.7 mm(3) 7Tesla magnetic resonance imaging in 16 patients with amnestic MCI, 9 with AD, and 29 controls. ERC, subiculum, cornu ammonis (CA)1, CA2, CA3, and dentate gyrus (DG)&CA4 were traced on T2-weighted images. Analyses of covariance, adjusted for age, sex, and intracranial volume showed that compared with controls and patients with MCI, patients with AD had significantly smaller ERC, subiculum, CA1, CA3, and DG&CA4 volumes. Trend analyses revealed similar associations between ERC and hippocampal subfields and diagnostic group. Older age was significantly associated with smaller CA1 and DG&CA4 volumes. In conclusion, almost all hippocampal subfields and ERC show volume reductions in patients with AD compared with controls and patients with MCI. Future, larger studies should determine which subfields are affected earliest in the disease process and what mechanisms underlie the volume loss.
authors.affiliation: Department of Neurology, Brain Center Rudolf Magnus, UMC Utrecht, Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, the Netherlands.
authors.forename: Laura E M
authors.initials: LE
authors.lastname: Wisse
authors.affiliation: Department of Neurology, Brain Center Rudolf Magnus, UMC Utrecht, Utrecht, the Netherlands.
authors.forename: Geert Jan
authors.initials: GJ
authors.lastname: Biessels
authors.affiliation: Department of Neurology, Brain Center Rudolf Magnus, UMC Utrecht, Utrecht, the Netherlands.
authors.forename: Sophie M
authors.initials: SM
authors.lastname: Heringa
authors.affiliation: Image Sciences Institute, UMC Utrecht, Utrecht, the Netherlands.
authors.forename: Hugo J
authors.initials: HJ
authors.lastname: Kuijf
authors.affiliation: Department of Geriatrics, UMC Utrecht, Utrecht, the Netherlands.
authors.forename: Dineke H L
authors.initials: DH
authors.lastname: Koek
authors.affiliation: Department of Radiology, UMC Utrecht, Utrecht, the Netherlands.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Luijten
authors.affiliation: Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, the Netherlands. Electronic address: m.geerlings@umcutrecht.nl.
authors.forename: Mirjam I
authors.initials: MI
authors.lastname: Geerlings
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000473:pathology*; D056547:CA1 Region, Hippocampal / Q000473:pathology*; D056651:CA2 Region, Hippocampal / Q000473:pathology*; D056654:CA3 Region, Hippocampal / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000473:pathology*; D018891:Dentate Gyrus / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D018728:Entorhinal Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D009929:Organ Size
keywords: 7Tesla; Aging; Alzheimer disease; Entorhinal cortex; Hippocampal subfields; Manual segmentation