title: Claudins in teleost fishes.
abstract: Teleost fishes are a large and diverse animal group that represent close to 50% of all described vertebrate species. This review consolidates what is known about the claudin (Cldn) family of tight junction (TJ) proteins in teleosts. Cldns are transmembrane proteins of the vertebrate epithelial/endothelial TJ complex that largely determine TJ permeability. Cldns achieve this by expressing barrier or pore forming properties and by exhibiting distinct tissue distribution patterns. So far, ~63 genes encoding for Cldn TJ proteins have been reported in 16 teleost species. Collectively, cldns (or Cldns) are found in a broad array of teleost fish tissues, but select genes exhibit restricted expression patterns. Evidence to date strongly supports the view that Cldns play a vital role in the embryonic development of teleost fishes and in the physiology of tissues and organ systems studied thus far.
authors.affiliation: Department of Biology; York University; Toronto, ON, Canada.
authors.forename: Dennis
authors.initials: D
authors.lastname: Kolosov
authors.affiliation: Department of Biology; York University; Toronto, ON, Canada.
authors.forename: Phuong
authors.initials: P
authors.lastname: Bui
authors.affiliation: Department of Biology; York University; Toronto, ON, Canada.
authors.forename: Helen
authors.initials: H
authors.lastname: Chasiotis
authors.affiliation: Department of Biology; York University; Toronto, ON, Canada.
authors.forename: Scott P
authors.initials: SP
authors.lastname: Kelly
keywords: Fugu; Tetraodon; claudin; epithelium; paracellular permeability; teleost fish; tight junction; whole genome duplication; zebrafish