title: Chemokines as potential markers in pediatric renal diseases.
abstract: Glomerular diseases and obstructive uropathies are the two most frequent causes of chronic kidney disease (CKD) in children. Recently, biomarkers have become a focus of clinical research as potentially useful diagnostic tools in pediatric renal diseases. Among several putative biomarkers, chemokines emerge as promising molecules since they play relevant roles in the pathophysiology of pediatric renal diseases. The evaluation of these inflammatory mediators might help in the management of diverse renal diseases in children and the detection of patients at high risk to develop CKD. The aim of this paper is to revise general aspects of chemokines and the potential link between chemokines and the most common pediatric renal diseases by including experimental and clinical evidence.
authors.affiliation: Unidade de Nefrologia Pediátrica, Departamento de Pediatria, Universidade Federal de Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, Brazil ; Instituto Nacional de Ciência e Tecnologia em Medicina Molecular (INCT-MM), Faculdade de Medicina, UFMG, 30130-100 Belo Horizonte, MG, Brazil ; Laboratório Interdisciplinar de Investigação Médica Faculdade de Medicina, UFMG, Avenida Alfredo Balena 190, 2nd Floor, Room No.281, 30130-100 Belo Horizonte, MG, Brazil.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Simões e Silva
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Medicina Molecular (INCT-MM), Faculdade de Medicina, UFMG, 30130-100 Belo Horizonte, MG, Brazil ; Laboratório Interdisciplinar de Investigação Médica Faculdade de Medicina, UFMG, Avenida Alfredo Balena 190, 2nd Floor, Room No.281, 30130-100 Belo Horizonte, MG, Brazil ; Departamento de Nefrologia, Santa Casa de Misericordia de Belo Horizonte, 30130-100 Belo Horizonte, MG, Brazil.
authors.forename: André Barreto
authors.initials: AB
authors.lastname: Pereira
authors.affiliation: Laboratório Interdisciplinar de Investigação Médica Faculdade de Medicina, UFMG, Avenida Alfredo Balena 190, 2nd Floor, Room No.281, 30130-100 Belo Horizonte, MG, Brazil ; Laboratório de Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, UFMG, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: Mauro Martins
authors.initials: MM
authors.lastname: Teixeira
authors.affiliation: Laboratório Interdisciplinar de Investigação Médica Faculdade de Medicina, UFMG, Avenida Alfredo Balena 190, 2nd Floor, Room No.281, 30130-100 Belo Horizonte, MG, Brazil.
authors.forename: Antônio Lúcio
authors.initials: AL
authors.lastname: Teixeira
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D018925:Chemokines / Q000235:genetics / Q000378:metabolism*; D002648:Child; D015870:Gene Expression; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D051436:Renal Insufficiency, Chronic / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D018925:Chemokines