title: Numerical simulations of the blood flow in the patient-specific arterial cerebral circle region.
abstract: The Cerebral Circle Region, also known as the Circle of Willis (CoW), is a loop of arteries that form arterial connections between supply arteries to distribute blood throughout the cerebral mass. Among the population, only 25% to 50% have a complete system of arteries forming the CoW. 3D time-varying simulations for three different patient-specific artery anatomies of CoW were performed in order to gain a better insight into the phenomena existing in the cerebral blood flow. The models reconstructed on the basis of computer tomography images start from the aorta and include the largest arteries that supply the CoW and the arteries of CoW. Velocity values measured during the ultrasound examination have been compared with the results of simulations. It is shown that the flow in the right anterior artery in some cases may be supplied from the left internal carotid artery via the anterior communicating artery. The investigations conducted show that the computational fluid dynamic tool, which provides high resolution in both time and space domains, can be used to support physicians in diagnosing patients of different ages and various anatomical arterial structures.
authors.affiliation: Institute of Turbomachinery, Lodz University of Technology, Medical Apparatus Division, 219/223 Wolczanska Str., 90-924 Lodz, Poland. Electronic address: piotr.reorowicz@p.lodz.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Reorowicz
authors.affiliation: Institute of Turbomachinery, Lodz University of Technology, Medical Apparatus Division, 219/223 Wolczanska Str., 90-924 Lodz, Poland. Electronic address: damian.obidowski@p.lodz.pl.
authors.forename: Damian
authors.initials: D
authors.lastname: Obidowski
authors.affiliation: Institute of Turbomachinery, Lodz University of Technology, Medical Apparatus Division, 219/223 Wolczanska Str., 90-924 Lodz, Poland. Electronic address: przemyslaw.klosinski@p.lodz.pl.
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Klosinski
authors.affiliation: Norbert Barlicki Memorial Teaching Hospital No. 1, Medical University of Lodz, 22 Kopcinskiego Str., 90-153 Lodz, Poland. Electronic address: szubertw@gmail.com.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Szubert
authors.affiliation: Norbert Barlicki Memorial Teaching Hospital No. 1, Medical University of Lodz, 22 Kopcinskiego Str., 90-153 Lodz, Poland. Electronic address: ludomir.stefanczyk@umed.lodz.pl.
authors.forename: Ludomir
authors.initials: L
authors.lastname: Stefanczyk
authors.affiliation: Institute of Turbomachinery, Lodz University of Technology, Medical Apparatus Division, 219/223 Wolczanska Str., 90-924 Lodz, Poland. Electronic address: krzysztof.jozwik@p.lodz.pl.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Jozwik
mesh_terms: D000369:Aged, 80 and over; D001011:Aorta / Q000502:physiology; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000502:physiology; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002941:Circle of Willis / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D008954:Models, Biological
keywords: Blood flow simulation; Cerebral arterial circle; Circle of Willis; Non-Newtonian blood model; Patient-specific arterial reconstruction