title: Auditory event-related potentials (P300) and mesial temporal sclerosis in temporal lobe epilepsy patients.
abstract: OBJECTIVE
  To investigate the role of centrally recorded P300 in patients suffering from mesial temporal sclerosis-temporal lobe epilepsy (MTS-TLE).
  
  
  METHODS
  Sixteen patients (3 men and 13 women; median age: 32.5 years old) suffering from TLE with MTS and 43 healthy controls (12 men and 31 women; median age: 35 years old) participated in the study. P300 was elicited using an auditory two-stimulus oddball paradigm. In order to address the aim of the study, we adopted two statistical approaches; hierarchical linear regression analyses and ROC curves.
  
  
  RESULTS
  After adjusting for age, MTS patients had a mean reduction of P300 amplitude by 6.93 μV and a mean increase of P300 latency by 38.78 ms, compared to controls. Age and MTS-TLE status accounted for 32 and 16% of the variance of latency and amplitude, respectively. Diagnostic analyses to detect MTS-TLE status revealed a sensitivity and specificity of 88 and 65% for amplitude and 81 and 70% for latency, respectively. No association between duration of disease and P300 characteristics were found.
  
  
  CONCLUSIONS
  This study, along with other studies, contributes to our understanding and clinical significance of centrally recorded P300s in MTS-TLE patients. Future studies should focus on the association of these P300s with cognition in such patients.
authors.affiliation: Department of Neurology, 417 Army Share Fund Hospital.
authors.forename: Artemios K
authors.initials: AK
authors.lastname: Artemiadis
authors.affiliation: University of Athens, 1st Neurological Clinic.
authors.forename: Maria
authors.initials: M
authors.lastname: Fili
authors.affiliation: University of Athens, 1st Neurological Clinic.
authors.forename: George
authors.initials: G
authors.lastname: Papadopoulos
authors.affiliation: University of Athens, 1st Neurological Clinic.
authors.forename: Fotini
authors.initials: F
authors.lastname: Christidi
authors.affiliation: University of Athens, Neurosurgical Clinic, Athens, Greece.
authors.forename: Stergios
authors.initials: S
authors.lastname: Gatzonis
authors.affiliation: University of Athens, 1st Neurological Clinic.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Zalonis
authors.affiliation: Department of Neurology, 417 Army Share Fund Hospital.
authors.forename: George
authors.initials: G
authors.lastname: Nikolaou
authors.affiliation: University of Athens, 1st Neurological Clinic.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Triantafyllou
mesh_terms: D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000209:etiology / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012598:Sclerosis / Q000150:complications / Q000503:physiopathology*; D013702:Temporal Lobe / Q000503:physiopathology*; D055815:Young Adult
keywords: P300; cognitive; epilepsy; event-related; hippocampal sclerosis