title: In vivo chemoembolization and magnetic resonance imaging of liver tumors by using iron oxide nanoshell/doxorubicin/poly(vinyl alcohol) hybrid composites.
abstract: A hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an in vivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent.
authors.affiliation: Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR (P. R. China). yixiang_wang@cuhk.edu.hk.
authors.forename: Yi-Xiang J
authors.initials: YX
authors.lastname: Wang
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zhu
authors.forename: Qi
authors.initials: Q
authors.lastname: Liang
authors.forename: Christopher H K
authors.initials: CH
authors.lastname: Cheng
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Ken Cham-Fai
authors.initials: KC
authors.lastname: Leung
mesh_terms: D000818:Animals; D016461:Chemoembolization, Therapeutic; D004317:Doxorubicin / Q000008:administration & dosage*; D005290:Ferric Compounds / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D049329:Nanostructures; D011142:Polyvinyl Alcohol / Q000008:administration & dosage*; D011817:Rabbits
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D004317:Doxorubicin; D011142:Polyvinyl Alcohol
keywords: antitumor agents; chemoembolization; drug delivery; iron oxide; liver cancer