title: Surgical placement of biologic mesh spacers prior to external beam radiation for retroperitoneal and pelvic tumors.
abstract: OBJECTIVE
  To determine the feasibility of surgical placement of biologic mesh spacers to displace bowel and other radiation-sensitive organs prior to external beam radiation for difficult retroperitoneal and pelvic tumors.
  
  
  METHODS
  Tumors were resected if possible, and intraoperative electron radiation therapy (IOERT) was directed to the tumor or tumor bed in selected patients. Biologic mesh spacers comprised of cadaveric human skin treated to remove cells and preserve extracellular matrix (Alloderm; Lifecell, Branchburg, NJ) were then placed around the tumor or tumor bed. External radiation techniques included proton beam radiation therapy (PBRT) and intensity modulated radiation therapy (IMRT).
  
  
  RESULTS
  Patients had primary sarcomas (n = 2), radiation-associated sarcomas (n = 1), or isolated metastases (n = 2) in the retroperitoneum or pelvis. One patient received preoperative radiation. Three tumors were marginally resected (R1 resection) while 2 tumors were left in situ, and 3 patients received IOERT (10-17 Gy) to the tumor or tumor bed. Up to 4 sheets of biologic mesh were used as spacers around the tumor or tumor bed to displace small bowel, colon, ureter, bladder, or pancreas. The average distance of the 4 closest organs prior to mesh placement was 1.3-9 mm and after mesh placement was 8.0-23.5 mm. Preoperative or postoperative radiation 36-76 Gy was delivered by IMRT or PBRT. There were no early complications from mesh placement and late complications possibly related to radiation included 1 vertebral body compression fracture and 1 deep vein thrombosis. There were no mesh-related infections and none of the meshes required removal. All 5 patients currently remain free of disease progression after 3-38 months.
  
  
  CONCLUSIONS
  Biologic mesh spacers can be placed around tumors or tumor beds to displace radiation-sensitive organs and may allow for safer delivery of external beam radiation.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: syoon@partners.org.
authors.forename: Sam S
authors.initials: SS
authors.lastname: Yoon
authors.affiliation: Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Yen-Lin
authors.initials: YL
authors.lastname: Chen
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Avinash
authors.initials: A
authors.lastname: Kambadakone
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Schmidt
authors.affiliation: Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: DeLaney