title: Transglutaminase regulation of cell function.
abstract: Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding functions that participate in regulation of cell fate in a wide range of cellular systems and are implicated to have roles in development of disease. This review highlights the mechanism of action of these proteins with respect to their structure, impact on cell differentiation and survival, role in cancer development and progression, and function in signal transduction. We also discuss the mechanisms whereby TG level is controlled and how TGs control downstream targets. The studies described herein begin to clarify the physiological roles of TGs in both normal biology and disease states.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Eckert
authors.forename: Mari T
authors.initials: MT
authors.lastname: Kaartinen
authors.forename: Maria
authors.initials: M
authors.lastname: Nurminskaya
authors.forename: Alexey M
authors.initials: AM
authors.lastname: Belkin
authors.forename: Gozde
authors.initials: G
authors.lastname: Colak
authors.forename: Gail V W
authors.initials: GV
authors.lastname: Johnson
authors.forename: Kapil
authors.initials: K
authors.lastname: Mehta
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology; D015398:Signal Transduction; D014158:Transcription, Genetic; D011503:Transglutaminases / Q000235:genetics / Q000378:metabolism*
chemical_list: D011503:Transglutaminases