title: The prevalence and genetic diversity of group A rotaviruses on pig farms in the Mekong Delta region of Vietnam.
abstract: Group A rotaviruses (ARoVs) are a common cause of severe diarrhea among children worldwide and the cause of approximately 45% of pediatric hospitalizations for acute diarrhea in Vietnam. ARoVs are known to cause significant economic losses to livestock producers by reducing growth performance and production efficiencies, however little is known about the implications of asymptomatic endemic circulation of ARoV. We aimed to determine the prevalence and predominant circulating genotypes of ARoVs on pig farms in a southern province of Vietnam. We found overall animal-level and farm-level prevalence of 32.7% (239/730) and 74% (77/104), respectively, and identified six different G types and 4 P types in various combinations (G2, G3, G4, G5, G9, G11 and P[6], P[13], P[23], and P[34]). There was no significant association between ARoV infection and clinical disease in pigs, suggesting that endemic asymptomatic circulation of ARoV may complicate rotavirus disease attribution during outbreaks of diarrhea in swine. Sequence analysis of the detected ARoVs suggested homology to recent human clinical cases and extensive genetic diversity. The epidemiological relevance of these findings for veterinary practitioners and to ongoing pediatric ARoV vaccine initiatives in Vietnam merits further study.
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Viet Nam.
authors.forename: Hong Anh
authors.initials: HA
authors.lastname: Pham
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Viet Nam.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Carrique-Mas
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Viet Nam.
authors.forename: Van Cuong
authors.initials: VC
authors.lastname: Nguyen
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Viet Nam.
authors.forename: Thi Hoa
authors.initials: TH
authors.lastname: Ngo
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Viet Nam.
authors.forename: Lam Anh
authors.initials: LA
authors.lastname: Nguyet
authors.affiliation: Nong Lam University, Thu Duc, Viet Nam.
authors.forename: Tien Duy
authors.initials: TD
authors.lastname: Do
authors.affiliation: Sub-Department of Animal Health, Dong Thap, Viet Nam.
authors.forename: Be Hien
authors.initials: BH
authors.lastname: Vo
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Viet Nam.
authors.forename: Vu Tra My
authors.initials: VT
authors.lastname: Phan
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Viet Nam; University of Edinburgh, London, United Kingdom.
authors.forename: Maia A
authors.initials: MA
authors.lastname: Rabaa
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Viet Nam; Centre for Tropical Medicine, Nuffield Department of Medicine, Oxford University, London, United Kingdom.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Farrar
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Viet Nam; Centre for Tropical Medicine, Nuffield Department of Medicine, Oxford University, London, United Kingdom; The London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Stephen
authors.initials: S
authors.lastname: Baker
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Viet Nam; Centre for Tropical Medicine, Nuffield Department of Medicine, Oxford University, London, United Kingdom. Electronic address: jbryant@oucru.org.
authors.forename: Juliet E
authors.initials: JE
authors.lastname: Bryant
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005243:Feces / Q000821:virology; D014644:Genetic Variation; D005838:Genotype; D010802:Phylogeny; D015995:Prevalence; D012044:Regression Analysis; D012307:Risk Factors; D012401:Rotavirus / Q000145:classification / Q000235:genetics / Q000502:physiology*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology*; D013552:Swine; D014744:Vietnam / Q000453:epidemiology
keywords: Pigs; Rotaviruses; Vietnam