title: Association between common genetic variants of α2A-, α2B- and α2C-adrenoceptors and the risk of silent brain infarction.
abstract: Silent brain infarction (SBI) is an asymptomatic cerebrovascular disorder. The aim of the present study was to investigate the association between adrenoceptor-α2 (ADRA2) gene polymorphisms and SBI. A total of 361 patients with SBI and 467 healthy control subjects were examined. The polymerase chain reaction was performed to genotype the ADRA2A 1780G>A, ADRA2B 301-303 insertion/deletion (I/D) and ADRA2C 322-325I/D polymorphisms. The frequency of the ADRA2C 322-325I/D polymorphism was significantly different between patients with SBI and control subjects. When interaction analyses were performed for vascular risk factors, the ADRA2C 322-325ID genotype increased the risk for SBI in the presence of hypertension and elevated plasma homocysteine levels. The ADRA2C 322-325ID genotype and plasma homocysteine levels showed a significant synergistic effect for SBI. In addition, the ADRA2A 1780AA genotype was associated with elevated plasma homocysteine levels. Although further analysis of the association between ADRA2 polymorphisms and clinical risk factors of SBI is required, the present study of a limited set of SBI risk factors with ADRA2 polymorphisms provides the first evidence of the involvement of ADRA2 gene family members in the development of SBI. Further studies using larger and more heterogeneous populations are required to validate the association of ADRA2 polymorphisms with SBI.
authors.affiliation: Institute for Clinical Research, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Gyeonggi-do 463-712, Republic of Korea.
authors.forename: Jung O
authors.initials: JO
authors.lastname: Kim
authors.affiliation: Institute for Clinical Research, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Gyeonggi-do 463-712, Republic of Korea.
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Jeon
authors.affiliation: Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do 463-712, Republic of Korea.
authors.forename: Ok Joon
authors.initials: OJ
authors.lastname: Kim
authors.affiliation: Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do 463-712, Republic of Korea.
authors.forename: Seung Hun
authors.initials: SH
authors.lastname: Oh
authors.affiliation: Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do 463-712, Republic of Korea.
authors.forename: Hyun Sook
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Neurology, Chonbuk National University Hospital and Medical School, Jeonju 561-712, Republic of Korea.
authors.forename: Byoung Soo
authors.initials: BS
authors.lastname: Shin
authors.affiliation: Institute for Clinical Research, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Gyeonggi-do 463-712, Republic of Korea.
authors.forename: Doyeun
authors.initials: D
authors.lastname: Oh
authors.affiliation: Department of Medicine, College of Medicine, Chung-Ang University Seoul 156-756, Republic of Korea.
authors.forename: Eo Jin
authors.initials: EJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, CHA Gangnam Medical Center, CHA University, Seoul 135-913, Republic of Korea.
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Cho
authors.affiliation: Institute for Clinical Research, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Gyeonggi-do 463-712, Republic of Korea.
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D000368:Aged; D000483:Alleles; D058070:Asymptomatic Diseases; D020520:Brain Infarction / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D012306:Risk
chemical_list: C547768:ADRA2A protein, human; C547771:ADRA2B protein, human; C547774:ADRA2C protein, human; D018341:Receptors, Adrenergic, alpha-2; D006710:Homocysteine