title: Combining genomic and genealogical information in a reproducing kernel Hilbert spaces regression model for genome-enabled predictions in dairy cattle.
abstract: Genome-enhanced genotypic evaluations are becoming popular in several livestock species. For this purpose, the combination of the pedigree-based relationship matrix with a genomic similarities matrix between individuals is a common approach. However, the weight placed on each matrix has been so far established with ad hoc procedures, without formal estimation thereof. In addition, when using marker- and pedigree-based relationship matrices together, the resulting combined relationship matrix needs to be adjusted to the same scale in reference to the base population. This study proposes a semi-parametric Bayesian method for combining marker- and pedigree-based information on genome-enabled predictions. A kernel matrix from a reproducing kernel Hilbert spaces regression model was used to combine genomic and genealogical information in a semi-parametric scenario, avoiding inversion and adjustment complications. In addition, the weights on marker- versus pedigree-based information were inferred from a Bayesian model with Markov chain Monte Carlo. The proposed method was assessed involving a large number of SNPs and a large reference population. Five phenotypes, including production and type traits of dairy cattle were evaluated. The reliability of the genome-based predictions was assessed using the correlation, regression coefficient and mean squared error between the predicted and observed values. The results indicated that when a larger weight was given to the pedigree-based relationship matrix the correlation coefficient was lower than in situations where more weight was given to genomic information. Importantly, the posterior means of the inferred weight were near the maximum of 1. The behavior of the regression coefficient and the mean squared error was similar to the performance of the correlation, that is, more weight to the genomic information provided a regression coefficient closer to one and a smaller mean squared error. Our results also indicated a greater accuracy of genomic predictions when using a large reference population.
authors.affiliation: Departamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain; Departamento Técnico Conafe, Madrid, Spain.
authors.forename: Silvia Teresa
authors.initials: ST
authors.lastname: Rodríguez-Ramilo
authors.affiliation: Departamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain.
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: García-Cortés
authors.affiliation: Departamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain; Department of Environment and Primary Industries, Biosciences Research Division, Melbourne, Victoria, Australia; Dairy Futures Cooperative Research Centre, Melbourne, Victoria, Australia.
authors.forename: Oscar
authors.initials: O
authors.lastname: González-Recio
mesh_terms: D000465:Algorithms; D000818:Animals; D001499:Bayes Theorem; D002417:Cattle / Q000235:genetics*; D023281:Genomics; D016014:Linear Models; D008390:Markov Chains; D008957:Models, Genetic; D009010:Monte Carlo Method; D010375:Pedigree