title: [Primary systemic AL amyloidosis with remarkable calcification in the spleen].
abstract: We report a 50-year-old female patient with diffuse and rapidly progressing splenic calcification. She had developed nephrotic syndrome and been diagnosed with renal amyloid light-chain amyloidosis in 2010. Although she had been given melphalan and dexamethasone therapy and high-dose melphalan followed by autologous blood stem-cell transplantation, her renal function worsened and hemodialysis was started in May 2011. Since November 2011, splenic calcification, probably associated with amyloidosis, had progressed, and diffuse calcification was observed throughout the splenic area in September 2012. During the same period, the patient was hospitalized for thrombocytopenia. Although splenic dysfunction due to calcification was suspected to be the cause of thrombocytopenia, the association between the two could not be established. The platelet count rose with an improvement in hepatic congestion due to reinforced fluid removal during dialysis.
authors.affiliation: Department of Hematology, Japanese Red Cross Medical Center.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Uchiyama
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tsukada
authors.forename: Kanji
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Yu
authors.initials: Y
authors.lastname: Abe
authors.forename: Rieko
authors.initials: R
authors.lastname: Sekine
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Kenshi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000686:Amyloidosis / Q000150:complications* / Q000628:therapy*; D002114:Calcinosis / Q000209:etiology*; D003907:Dexamethasone / Q000008:administration & dosage; D018450:Disease Progression; D005260:Female; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications; D036102:Peripheral Blood Stem Cell Transplantation; D051437:Renal Insufficiency / Q000209:etiology / Q000628:therapy; D013158:Splenic Diseases / Q000209:etiology*; D013921:Thrombocytopenia / Q000209:etiology; D014182:Transplantation, Autologous
chemical_list: D003907:Dexamethasone; D008558:Melphalan