title: Treatment options for acute pancreatitis.
abstract: This Review covers the latest developments in the treatment of acute pancreatitis. The Atlanta Classification of acute pancreatitis has been revised, proposing several new terms and abandoning some of the old and confusing terminology. The 2012 Revised Atlanta Classification and the determinant-based classification aim to universally define the different local and systemic complications and predict outcome. The most important differences between these classifications are discussed. Several promising treatment options for the early management of acute pancreatitis have been tested, including the use of enteral nutrition and antibiotics as well as novel therapies such as haemofiltration and protease inhibitors. The results are summarized and the quality of evidence is discussed. Finally, new developments in the management of patients with infected pancreatic necrosis are addressed, including the use of the 'step-up approach' and results of minimally invasive necrosectomy.
authors.affiliation: Department of Surgery, Room G04.228, University Medical Center Utrecht Heidelberglaan 100, PO Box 85500, 3508 GA Utrecht, Netherlands.
authors.forename: Olaf J
authors.initials: OJ
authors.lastname: Bakker
authors.affiliation: Department of Surgery (Suite G4-136), Academic Medical Center, Meibergdreef 9, 1105 AZ, PO Box 22660, 1100 DD Amsterdam, Netherlands.
authors.forename: Yama
authors.initials: Y
authors.lastname: Issa
authors.affiliation: Department of Surgery, Room G04.228, University Medical Center Utrecht Heidelberglaan 100, PO Box 85500, 3508 GA Utrecht, Netherlands.
authors.forename: Hjalmar C
authors.initials: HC
authors.lastname: van Santvoort
authors.affiliation: Department of Surgery (Suite G4-136), Academic Medical Center, Meibergdreef 9, 1105 AZ, PO Box 22660, 1100 DD Amsterdam, Netherlands.
authors.forename: Marc G
authors.initials: MG
authors.lastname: Besselink
authors.affiliation: Department of Gastroenterology &Hepatology, Erasmus Medical Center, University Medical Center Rotterdam, 's-Gravendijkwal 230, 3015 CE Rotterdam, Netherlands.
authors.forename: Nicolien J
authors.initials: NJ
authors.lastname: Schepers
authors.affiliation: Department of Gastroenterology &Hepatology, Erasmus Medical Center, University Medical Center Rotterdam, 's-Gravendijkwal 230, 3015 CE Rotterdam, Netherlands.
authors.forename: Marco J
authors.initials: MJ
authors.lastname: Bruno
authors.affiliation: Department of Surgery (Suite G4-136), Academic Medical Center, Meibergdreef 9, 1105 AZ, PO Box 22660, 1100 DD Amsterdam, Netherlands.
authors.forename: Marja A
authors.initials: MA
authors.lastname: Boermeester
authors.affiliation: Department of Operation Rooms/Evidence Based Surgery, Radboud University Medical Centre, Geert Grooteplein zuid 10, PO Box 9101, 6500 HB Nijmegen, Netherlands.
authors.forename: Hein G
authors.initials: HG
authors.lastname: Gooszen
mesh_terms: D000208:Acute Disease; D006801:Humans; D010195:Pancreatitis / Q000145:classification / Q000150:complications / Q000628:therapy*