title: Clinical phenotype of scabies by age.
abstract: OBJECTIVE
  Scabies has a clinical presentation that seems to vary according to age. We conducted a prospective study with the goal of delineating the clinical presentation of the disease into 3 groups of age: infants, <2 years; children, 2 to 15 years; and adults, >15 years.
  
  
  METHODS
  This trial was a prospective, multicenter observational study in consecutive patients with a confirmed diagnosis of scabies who were seen in 13 French Departments of Dermatology and Pediatric Dermatology between April 2010 and April 2011. A standardized questionnaire was completed for each patient. To identify factors associated with patient age, comparisons between the 3 age groups were conducted by using univariate and multivariate multinomial logistic regression analyses.
  
  
  RESULTS
  A total of 323 individuals were included; the gender ratio (female:male) was 1.2:1. In univariate analysis, infants were more likely to have facial involvement. In multivariate logistic regression, relapse was more frequent in children (odds ratio [OR]: 2.45 [95% confidence interval (CI):1.23-4.88]) and infants (OR: 3.26 [95% CI: 1.38-7.71]). In addition, family members with itch (OR: 2.47 [95% CI: 1.04-5.89]), plantar (OR: 20.57 [95% CI: 7.22-58.60]), and scalp (OR: 16.94 [95% CI: 3.70-77.51]) involvement were also found to be independently associated with the age group <2 years.
  
  
  CONCLUSIONS
  There is a specific clinical presentation of scabies in infants and children. Taking into account these specificities may be helpful for the early diagnosis and the identification of cases to prevent the propagation of the disease.
authors.affiliation: Pediatric Dermatology Unit, Hôpital Pellegrin-enfants, Bordeaux University Hospital, Bordeaux, France;
authors.forename: Franck
authors.initials: F
authors.lastname: Boralevi
authors.forename: Abou
authors.initials: A
authors.lastname: Diallo
authors.forename: Juliette
authors.initials: J
authors.lastname: Miquel
authors.forename: Morgane
authors.initials: M
authors.lastname: Guerin-Moreau
authors.forename: Didier
authors.initials: D
authors.lastname: Bessis
authors.forename: Christine
authors.initials: C
authors.lastname: Chiavérini
authors.forename: Patrice
authors.initials: P
authors.lastname: Plantin
authors.forename: Thomas
authors.initials: T
authors.lastname: Hubiche
authors.forename: Annabel
authors.initials: A
authors.lastname: Maruani
authors.forename: Martin
authors.initials: M
authors.lastname: Lassalle
authors.forename: Lucile
authors.initials: L
authors.lastname: Boursault
authors.forename: Khaled
authors.initials: K
authors.lastname: Ezzedine
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D010641:Phenotype; D011446:Prospective Studies; D012532:Scabies / Q000235:genetics*
keywords: infants; phenotype; scabies