title: Mimicking the nanostructure of bone matrix to regenerate bone.
abstract: Key features of bone tissue structure and composition are capable of directing cellular behavior towards the generation of new bone tissue. Bone tissue, as well as materials derived from bone, have a long and successful history of use as bone grafting materials. Recent developments in design and processing of synthetic scaffolding systems has allowed the replication of the bone's desirable biological activity in easy to fabricate polymeric materials with nano-scale features exposed on the surface. The biological response to these new tissue-engineering scaffold materials oftentimes exceeds that seen on scaffolds produced using biological materials.
authors.affiliation: Department of Biologic and Materials Sciences, University of Michigan, 1011 North University Ave., Room 2209, Ann Arbor, MI 48109, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Kane
authors.affiliation: Department of Biologic and Materials Sciences, University of Michigan, 1011 North University Ave., Room 2209, Ann Arbor, MI 48109, USA ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA ; Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA ; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Peter X
authors.initials: PX
authors.lastname: Ma1
keywords: Biomimetic; Bone tissue engineering; Nanofiber; Scaffold; Thermally induced phase separation