title: Effects of bone cement on intervertebral disc degeneration.
abstract: Percutaneous vertebroplasty (PVP) is popular for the treatment of intractable pain due to vertebral collapse from various lesions, intervertebral disk leakage of cement is a frequent complication. The aim of this study was to determine whether bone cement causes disc degeneration, and to evaluate the degree of intervertebral disc degeneration (IDD) according to the time period following cement injection, and the type and volume of cement injected. Sixteen dogs were randomly divided into two groups that were sacrificed at 12 or 24 weeks following cement injection. Five intervertebral discs in each dog were studied, including one control untreated disc and four discs randomly injected with polymethylmethacrylate (PMMA) or calcium phosphate cement (CPC) in two quantities. Radiographic and magnetic resonance imaging (MRI) studies were performed prior to animal sacrifice. T2-weighted mid-sagittal images of the discs were qualitatively analyzed for evidence of degeneration by calculating the MRI index, and all harvested discs were studied histopathologically. IDD was not evident in control discs. Univariate analysis revealed significant differences in the MRI index and the histological grade of disc degeneration in terms of the time period following cement injection, as well as the type and volume of cement injected. Result indicate that direct contact with PMMA and CPC can lead to IDD. However, IDD induced by PMMA was more severe than that induced by CPC. The extent of IDD was found to correlate with the time period post-cement injection and the volume of cement injected into the disc. PMMA and CPC may lead to intervertebral disc degeneration. Intervertebral disc degeneration induced by PMMA is more serious than that of CPC. The degree of intervertebral disc degeneration is correlative to the time after operation and the doses of bone cement.
authors.affiliation: Department of Interventional Radiology, The Hospital Affiliated of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Nantong, Jiangsu 215006, P.R. China.
authors.forename: Cai-Fang
authors.initials: CF
authors.lastname: Ni
authors.affiliation: Department of Interventional Radiology, The Hospital Affiliated of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Interventional Radiology, The Hospital Affiliated of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Su-Ming
authors.initials: SM
authors.lastname: Zhao
authors.affiliation: Department of Interventional Radiology, The Hospital Affiliated of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Gu
authors.affiliation: Department of Interventional Radiology, The Hospital Affiliated of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Nantong, Jiangsu 215006, P.R. China.
authors.forename: Long
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Nantong, Jiangsu 215006, P.R. China.
authors.forename: Tian-Si
authors.initials: TS
authors.lastname: Tan
keywords: calcium phosphate cement; degeneration; intervertebral disc; magnetic resonance imaging; polymethyl methacrylate; vertebroplasty