title: Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells.
abstract: Mitochondrial permeabilisation after NO donor application did not activate caspase-9. We have studied the X-linked apoptosis inhibitor (XIAP) and Aven protein content in NO-treated Jurkat cells. The level of both proteins increased in NO-treated cells. Thus the increase in XIAP and Aven content could be the cause of the lack of caspase-9 activity after mitochondrial permeabilisation in NO-treated Jurkat cells.
authors.affiliation: Siberian State Medical University of the Ministry of Health Care of the Russian Federation, 634055, Tomsk, Russia.
authors.forename: Elena G
authors.initials: EG
authors.lastname: Starikova
authors.forename: L A
authors.initials: LA
authors.lastname: Tashireva
authors.forename: V V
authors.initials: VV
authors.lastname: Novitsky
authors.forename: N V
authors.initials: NV
authors.lastname: Ryazantseva
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D053453:Caspase 9 / Q000378:metabolism; D006801:Humans; D019169:Jurkat Cells; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008565:Membrane Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D010539:Permeability / Q000187:drug effects; D014226:Triazenes / Q000494:pharmacology*; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000378:metabolism*
chemical_list: C114535:1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene; C412506:AVEN protein, human; D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D008565:Membrane Proteins; D020030:Nitric Oxide Donors; D014226:Triazenes; D051636:X-Linked Inhibitor of Apoptosis Protein; D053453:Caspase 9
keywords: Aven; XIAP; apoptosis; caspase; mitochondria; nitric oxide