title: Lipase inhibitory activity of chlorophyll a, isofucosterol and saringosterol isolated from chloroform fraction of Sargassum thunbergii.
abstract: Three compounds (chlorophyll a, isofucosterol and saringosterol) were isolated from chloroform fraction of Sargassum thunbergii extract. The three compounds had two- to fourfold lower lipase inhibitory activity than that of the CHCl3:MeOH (C:M) (100:1) fraction (fraction I, 83.78% at 1 mg/mL). These results suggested that the high lipase inhibitory activity of fraction I was attributable to the actions of the three compounds. Therefore, S. thunbergii has potential for application as an anti-obesity agent.
authors.affiliation: a Institute of Fisheries Sciences, Pukyong National University , Busan 619-911 , Republic of Korea.
authors.forename: Koth-Bong-Woo-Ri
authors.initials: KB
authors.lastname: Kim
authors.forename: Min-Ji
authors.initials: MJ
authors.lastname: Kim
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Ahn
mesh_terms: D019440:Anti-Obesity Agents; D002725:Chloroform; D002734:Chlorophyll / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000077194:Chlorophyll A; D008049:Lipase / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D044647:Sargassum / Q000737:chemistry*; D013265:Stigmasterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D019440:Anti-Obesity Agents; C442582:saringosterol; D002734:Chlorophyll; C085815:chlorophyll a'; C015896:fucosterol; D002725:Chloroform; D013265:Stigmasterol; D008049:Lipase; D000077194:Chlorophyll A
keywords: Sargassum thunbergii; anti-obesity; chlorophyll a; isofucosterol; saringosterol