title: Lethal cervical abscess following bisphosphonate related osteonecrosis of the jaw.
abstract: BACKGROUND
  Bisphosphonates are common drugs used in the management of bone metabolic diseases. Because of their recently increased use, their adverse effects, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), are monitored more frequently. BRONJ is a critical challenge in craniofacial surgery and is difficult to treat. Its occurrence is either spontaneous or follows dentoalveolar surgery. Typical complications of BRONJ are painful exposed bone, pathological fractures, extra-oral fistula, and local infections.
  
  
  OBJECTIVE
  The aim of this paper is to report a rare case of bacterial embolism in the internal jugular vein after a BRONJ-induced submandibular abscess resulting in bacterial sepsis, multi-organ failure syndrome, and death.
  
  
  METHODS
  A 59-year-old female patient developed severe BRONJ (stage II) with recurrent abscesses after oral osteoporosis therapy with alendronic acid. A subsequent submandibular abscess led to bacterial embolism of the left internal jugular vein, causing sepsis and death.
  
  
  CONCLUSIONS
  Prevention, early detection and management of BRONJ remain a crucial challenge in craniofacial clinical practice. Despite several therapeutic approaches described in the current literature, none have undergone bedside application.
  
  
  CONCLUSIONS
  Considering this report of death after recurrent abscesses following BRONJ, the use of bisphosphonates should be carefully monitored in order to prevent such severe complications.
authors.affiliation: Department of Cranio-Maxillo-Facial Surgery (Director: Prof. Dr. Dr. H.-P. Howaldt), Justus-Liebig-University, Klinikstraße 29, 35392 Gießen, Germany. Electronic address: Christopher.kaehling@uniklinikum-giessen.de.
authors.forename: Ch
authors.initials: Ch
authors.lastname: Kaehling
authors.affiliation: Department of Cranio-Maxillo-Facial Surgery (Director: Prof. Dr. Dr. H.-P. Howaldt), Justus-Liebig-University, Klinikstraße 29, 35392 Gießen, Germany.
authors.forename: Ph
authors.initials: P
authors.lastname: Streckbein
authors.affiliation: Department of Cranio-Maxillo-Facial Surgery (Director: Prof. Dr. Dr. H.-P. Howaldt), Justus-Liebig-University, Klinikstraße 29, 35392 Gießen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Schmermund
authors.affiliation: Department of Anesthesiology (Director: Prof. Dr. M. Weigand), Intensive Care Medicine and Pain Therapy, Justus-Liebig-University Giessen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Henrich
authors.affiliation: Department of Pathology (Director: Prof. Dr. S. Gattenloehner), Justus-Liebig-University Giessen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Burchert
authors.affiliation: Department of Pathology (Director: Prof. Dr. S. Gattenloehner), Justus-Liebig-University Giessen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Gattenloehner
authors.affiliation: Department of Cranio-Maxillo-Facial Surgery (Director: Prof. Dr. Dr. H.-P. Howaldt), Justus-Liebig-University, Klinikstraße 29, 35392 Gießen, Germany.
authors.forename: H-P
authors.initials: HP
authors.lastname: Howaldt
authors.affiliation: Department of Cranio-Maxillo-Facial Surgery (Director: Prof. Dr. Dr. H.-P. Howaldt), Justus-Liebig-University, Klinikstraße 29, 35392 Gießen, Germany.
authors.forename: J-F
authors.initials: JF
authors.lastname: Wilbrand
mesh_terms: D000038:Abscess / Q000209:etiology*; D019386:Alendronate / Q000009:adverse effects; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000150:complications*; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007601:Jugular Veins / Q000382:microbiology; D008336:Mandibular Diseases / Q000150:complications*; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000382:microbiology; D009333:Neck / Q000473:pathology*; D012772:Shock, Septic / Q000382:microbiology; D054556:Venous Thromboembolism / Q000382:microbiology
chemical_list: D050071:Bone Density Conservation Agents; D019386:Alendronate
keywords: BRONJ; Bacterial embolism; Bisphosphonate; Lethal cervical abscess; Osteonecrosis