title: Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice.
abstract: Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin tumors and is the most common tumor in the western world. BCC arises due to mutations in the tumor suppressor gene Patched1 (Ptch). Analysis of the conditional Ptch knockout mouse model for BCC reveals that macrophages and dendritic cells (DC) of the skin play an important role in BCC growth restraining processes. This is based on the observation that a clodronate-liposome mediated depletion of these cells in the tumor-bearing skin results in significant BCC enlargement. The depletion of these cells does not modulate Ki67 or K10 expression, but is accompanied by a decrease in collagen-producing cells in the tumor stroma. Together, the data suggest that cutaneous macrophages and DC in the tumor microenvironment exert an antitumor effect on BCC.
authors.affiliation: Institute of Human Genetics, University Medical Center, Goettingen, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: König
authors.affiliation: Institute of Human Genetics, University Medical Center, Goettingen, Germany.
authors.forename: Frauke
authors.initials: F
authors.lastname: Nitzki
authors.affiliation: Institute of Human Genetics, University Medical Center, Goettingen, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Uhmann
authors.affiliation: Institute of Cellular and Molecular Immunology, University Medical Center, Goettingen, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Dittmann
authors.affiliation: Institute of Cellular and Molecular Immunology, University Medical Center, Goettingen, Germany.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Theiss-Suennemann
authors.affiliation: Department of Radiation Oncology, University Medical Center, Goettingen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Herrmann
authors.affiliation: Institute of Cellular and Molecular Immunology, University Medical Center, Goettingen, Germany.
authors.forename: Holger M
authors.initials: HM
authors.lastname: Reichardt
authors.affiliation: Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
authors.forename: Reto
authors.initials: R
authors.lastname: Schwendener
authors.affiliation: Department of Hematology and Oncology, University Medical Center, Goettingen, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Pukrop
authors.affiliation: Department of Neuropathology, University Medical Center, Goettingen, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Schulz-Schaeffer
authors.affiliation: Institute of Human Genetics, University Medical Center, Goettingen, Germany.
authors.forename: Heidi
authors.initials: H
authors.lastname: Hahn
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics*; D002280:Basal Cell Carcinoma / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004002:Clodronic Acid / Q000008:administration & dosage; D003713:Dendritic Cells / Q000187:drug effects / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage; D008264:Macrophages / Q000187:drug effects / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; D011956:Receptors, Cell Surface / Q000235:genetics*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D059016:Tumor Microenvironment / Q000187:drug effects / Q000235:genetics
chemical_list: D008081:Liposomes; C000606236:PTCH1 protein, human; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; C000606240:Ptch1 protein, mouse; D011956:Receptors, Cell Surface; D004002:Clodronic Acid