title: Radiochemical synthesis of 2'-[18F]-labelled and 3'-[18F]-labelled nucleosides for positron emission tomography imaging.
abstract: This review article considers 2'-labelled and 3'-labelled nucleosides, which are of great importance as positron emission tomography (PET) probes in clinical diagnostics and PET research. Although the radiochemical preparation of several [(18)F]-labelled nucleosides such as [(18)F]fluorothymidine or [(18)F](fluoroarabinofuranosyl)cytosine has been accomplished within the last two decades, a number of potentially interesting nucleoside-based biomarkers are not yet available for automated good manufacturing practice production due to the lack of fast and efficient synthetic methods for late-stage [(18)F]-introduction. In order to meet recent demands for new PET-based biomarkers in various clinical applications, appropriate precursors that can easily be fluorinated and deprotected need to be developed.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, Wales, UK; Wales Research & Diagnostic PET Imaging Centre (PETIC), Institute for Translation, Innovation, Methodology & Engagement (TIME), School of Medicine, Heath Park, Cardiff University, Cardiff, CF14 4XN, Wales, UK.
authors.forename: Jan-Philip
authors.initials: JP
authors.lastname: Meyer
authors.forename: Katrin C
authors.initials: KC
authors.lastname: Probst
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Westwell
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007553:Isotope Labeling / Q000379:methods; D057054:Molecular Imaging / Q000379:methods; D009705:Nucleosides / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis
chemical_list: D003287:Contrast Media; D005462:Fluorine Radioisotopes; D009705:Nucleosides; D019275:Radiopharmaceuticals
keywords: [18F]-incorporation; late stage precursor; nucleoside analogues; radiosynthesis