title: Obesity-related gene ADRB2, ADRB3 and GHRL polymorphisms and the response to a weight loss diet intervention in adult women.
abstract: The individual response to diet may be influenced by gene polymorphisms. This study hypothesized that ADRB2 (Gln27Glu, rs1042714 and Arg16Gly, rs1042713), ADRB3 (Trp64Arg, rs4994) and GHRL (Leu72Met, rs696217) polymorphisms moderate weight loss. The study was a seven weeks dietary weight loss intervention with Brazilian adult obese women (n = 109). The body mass index (BMI) was calculated and polymorphisms in these genes were assessed by real-time PCR assays. Two-way repeated-measures ANOVA (2 × 2) were used to analyze the intervention effect between polymorphisms and BMI over the period and after stratification for age and socioeconomic status (SES). The weight loss intervention resulted in decreased BMI over the seven-week period (p < 0.001), for high and low SES (p < 0.05) and mainly for participants with 30-49 y. The intervention did not result in a statistically significant difference in weight loss between polymorphism carriers and non-carriers, and although, the ADRB2, ADRB3 and GHRL polymorphisms did not moderate weight loss, the Gln27Glu polymorphism carriers showed a lower BMI compared to non-carriers in the low SES (p = 0.018) and the 30-39 y (p = 0.036) groups, suggesting a role for this polymorphism related to BMI control.
authors.affiliation: Departamento de Genética, Universidade Federal do Paraná, Curitiba, PR, Brazil . ; Escola de Saúde e Biociências, Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil .
authors.forename: Louise F
authors.initials: LF
authors.lastname: Saliba
authors.affiliation: Escola de Saúde e Biociências, Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil . ; Departamento de Educação Física, Universidade Federal do Paraná, Curitiba, PR, Brazil .
authors.forename: Rodrigo S
authors.initials: RS
authors.lastname: Reis
authors.affiliation: Prevention Research Center in St. Louis, Brown School, Washington University in St. Louis, St. Louis, MO, USA . ; Division of Public Health Sciences and Alvin J. Siteman Cancer Center, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA .
authors.forename: Ross C
authors.initials: RC
authors.lastname: Brownson
authors.affiliation: Escola de Saúde e Biociências, Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil . ; Departamento de Educação Física, Universidade Federal do Paraná, Curitiba, PR, Brazil .
authors.forename: Adriano A
authors.initials: AA
authors.lastname: Hino
authors.affiliation: Departamento de Genética, Universidade Federal do Paraná, Curitiba, PR, Brazil .
authors.forename: Luciane V
authors.initials: LV
authors.lastname: Tureck
authors.affiliation: Prevention Research Center in St. Louis, Brown School, Washington University in St. Louis, St. Louis, MO, USA .
authors.forename: Cheryl
authors.initials: C
authors.lastname: Valko
authors.affiliation: Departamento de Genética, Universidade Federal do Paraná, Curitiba, PR, Brazil .
authors.forename: Ricardo L R
authors.initials: RL
authors.lastname: de Souza
authors.affiliation: Departamento de Genética, Universidade Federal do Paraná, Curitiba, PR, Brazil .
authors.forename: Lupe
authors.initials: L
authors.lastname: Furtado-Alle
keywords: adrenergic receptor polymorphism; ghrelin polymorphism; nutrigenetics; obesity; weight loss