title: Gestational trophoblastic neoplasia: A 6 year retrospective study.
abstract: OBJECTIVE
  To study the clinical presentations of gestational trophoblastic neoplasia and its response to chemotherapy.
  
  
  METHODS
  This is a retrospective study of 28 women of gestational trophoblastic neoplasia evaluated over a period of 6 years from January 2004 to December 2009. Patients were evaluated on the basis of their age, number of deliveries, history of abortion or molar pregnancy, and the treatment received. All patients were scored on the basis of WHO scoring system. Patients with low risk (score </=6) received single agent chemotherapy with methotrexate or actinomycin D. Patients with high risk (score >/=7) received multiple agent chemotherapy with EMACO regimen. After completion of chemotherapy patients were followed for a minimum of 2 years. The response to treatment was evaluated during follow-up by clinical examination, beta hCG levels and imaging as and when required.
  
  
  RESULTS
  Out of 28 women only 27 could be evaluated, because 1 patient was lost to follow-up. Out of 27 patients, 18 patients (66.67%) achieved complete remission with the first-line chemotherapy and additional 25.92% (7/27) achieved complete remission with second line chemotherapy resulting in complete remission of 92.5% (25/27).
  
  
  CONCLUSIONS
  Gestational trophoblastic neoplasia is curable if patient is properly evaluated and scored. It shows good response to chemotherapy.
authors.affiliation: Department of Gynaecologic Oncology, Dr. B. Borooah Cancer Institute (RCC), Gopinath Nagar, Guwahati, Assam, India.
authors.forename: Sushruta
authors.initials: S
authors.lastname: Shrivastava
authors.affiliation: Department of Gynaecologic Oncology, Dr. B. Borooah Cancer Institute (RCC), Gopinath Nagar, Guwahati, Assam, India.
authors.forename: Amal Chandra
authors.initials: AC
authors.lastname: Kataki
authors.affiliation: Department of Gynaecologic Oncology, Dr. B. Borooah Cancer Institute (RCC), Gopinath Nagar, Guwahati, Assam, India.
authors.forename: Debabrata
authors.initials: D
authors.lastname: Barmon
authors.affiliation: Department of Gynaecologic Oncology, Dr. B. Borooah Cancer Institute (RCC), Gopinath Nagar, Guwahati, Assam, India.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Deka
authors.affiliation: Department of Medical Oncology, Dr. B. Borooah Cancer Institute (RCC), Gopinath Nagar, Guwahati, Assam, India.
authors.forename: Chidananda
authors.initials: C
authors.lastname: Bhuyan
authors.affiliation: Department of Medical Oncology, Dr. B. Borooah Cancer Institute (RCC), Gopinath Nagar, Guwahati, Assam, India.
authors.forename: Saikia J
authors.initials: SJ
authors.lastname: Bhargav
keywords: Actinomycin-D; EMACO regimen; Methotrexate; chemotherapy; choriocarcinoma; gestational trophoblastic neoplasia