title: The single-port concept: combining optical glucose measurement with insulin infusion.
abstract: The aim of this study was to develop a single-port system that combines glucose monitoring and insulin infusion. In a preclinical proof-of-concept trial, the performance of the glucose measurement at the site of insulin infusion was assessed. Glucose levels were clamped from 40 to 250 mg/dL by intravenous glucose infusion and subcutaneous insulin infusion via the glucose sensor. Sensor-glucose values correlated well with reference blood-glucose values, despite infusion at the site of glucose measurement. The average median ARE value was 21.6 ± 5.7 % for sensors used for insulin infusion, 18.1 ± 5.8 % for sensors used for NaCl infusion and 19.2 ± 7.9 % for sensors without infusion. These preclinical in vivo results demonstrate that single-port glucose monitoring is feasible at the site of insulin infusion.
authors.affiliation: HEALTH - Institute for Biomedicine and Health Sciences, Joanneum Research, Graz, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Hajnsek
authors.forename: Barbara
authors.initials: B
authors.lastname: Nacht
authors.forename: Stefan
authors.initials: S
authors.lastname: Sax
authors.forename: Emil J W
authors.initials: EJ
authors.lastname: List
authors.forename: Ingo
authors.initials: I
authors.lastname: Klimant
authors.forename: Frank
authors.initials: F
authors.lastname: Sinner
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation / Q000379:methods*; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D007332:Insulin Infusion Systems
chemical_list: D001786:Blood Glucose; D007328:Insulin