title: Multifunctional PEGylated multiwalled carbon nanotubes for enhanced blood pool and tumor MR imaging.
abstract: Long-circulating multifunctional Gd(III)-loaded multiwalled carbon nanotubes (MWCNTs) modified with polyethylene glycol are designed and synthesized. The formed MWCNTs are water-dispersible, stable, and have good cytocompatibility and antifouling property. With the low r 2 /r 1 relaxivity ratio and relatively long blood circulation time, the multifunctional MWCNTs are able to be used as a platform for enhanced blood pool and tumor MR imaging.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai, 201620, China; College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China.
authors.forename: Shihui
authors.initials: S
authors.lastname: Wen
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhao
authors.forename: Xiao
authors.initials: X
authors.lastname: An
authors.forename: Jingyi
authors.initials: J
authors.lastname: Zhu
authors.forename: Wenxiu
authors.initials: W
authors.lastname: Hou
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Huang
authors.forename: Mingwu
authors.initials: M
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Shi
mesh_terms: D000818:Animals; D015637:Gated Blood-Pool Imaging / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D011092:Polyethylene Glycols
chemical_list: D037742:Nanotubes, Carbon; D011092:Polyethylene Glycols
keywords: PEGylation; blood pool MR imaging; multiwalled carbon nanotubes; polyethyleneimine; tumor MR imaging