title: Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease.
abstract: Alzheimer's disease is the most common form of age-related neurodegenerative dementia. The disease is characterised by the presence of plaques in the cerebral cortex. The major constituent of these plaques is aggregated amyloid-β peptide. This review focuses on the molecular aspects of metal complexes designed to bind to amyloid-β. The development of radioactive metal-based complexes of copper and technetium designed as diagnostic imaging agents to detect amyloid burden in the brain is discussed. Separate sections of the review discuss the use of luminescent metal complexes to act as non-conventional probes of amyloid formation and recent research into the use of metal complexes as inhibitors of amyloid formation and toxicity.
authors.affiliation: School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, 3010, Australia. pauld@unimelb.edu.au.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hayne
authors.forename: SinChun
authors.initials: S
authors.lastname: Lim
authors.forename: Paul S
authors.initials: PS
authors.lastname: Donnelly
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D003300:Copper / Q000737:chemistry; D006801:Humans; D011485:Protein Binding; D019275:Radiopharmaceuticals / Q000737:chemistry; D013667:Technetium / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D056831:Coordination Complexes; D019275:Radiopharmaceuticals; D013667:Technetium; D003300:Copper