title: Drug delivery with PEGylated MoS2 nano-sheets for combined photothermal and chemotherapy of cancer.
abstract: MoS2 nanosheets functionalized with poly-ethylene glycol are for the first time used as a multifunctional drug delivery system with high drug loading capacities. Using doxorubicin as the model drug and taking advantages of the strong near-infrared absorbance of MoS2, combined photothermal and chemotherapy of cancer is realized in animal experiments, achieving excellent synergistic anti-tumor effect upon systemic administration.
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM) & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Liu
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Xing
authors.initials: X
authors.lastname: Gu
authors.forename: Hua
authors.initials: H
authors.lastname: Gong
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.forename: Xiaoze
authors.initials: X
authors.lastname: Shi
authors.forename: Liangzhu
authors.initials: L
authors.lastname: Feng
authors.forename: Baoquan
authors.initials: B
authors.lastname: Sun
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002735:Chlorophyllides; D003131:Combined Modality Therapy; D004220:Disulfides / Q000009:adverse effects / Q000138:chemical synthesis / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000009:adverse effects / Q000737:chemistry*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D000077146:Irinotecan; D007624:KB Cells; D008325:Mammary Neoplasms, Experimental / Q000628:therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008982:Molybdenum / Q000009:adverse effects / Q000737:chemistry*; D049329:Nanostructures / Q000009:adverse effects / Q000737:chemistry*; D010789:Phototherapy / Q000379:methods*; D010865:Pilot Projects; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000138:chemical synthesis / Q000737:chemistry*; D011166:Porphyrins / Q000008:administration & dosage / Q000493:pharmacokinetics; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D000970:Antineoplastic Agents; D002735:Chlorophyllides; D004220:Disulfides; D004337:Drug Carriers; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; D011092:Polyethylene Glycols; C062985:phytochlorin; D000077146:Irinotecan; D004317:Doxorubicin; D008982:Molybdenum; D002166:Camptothecin; C082964:molybdenum disulfide
keywords: 2D nanostructure; MoS2 nanosheet; combination therapy; drug delivery; photothermal therapy