title: Early onset Alzheimer's disease and oxidative stress.
abstract: Alzheimer's disease (AD) is the most common cause of dementia in elderly adults. It is estimated that 10% of the world's population aged more than 60-65 years could currently be affected by AD, and that in the next 20 years, there could be more than 30 million people affected by this pathology. One of the great challenges in this regard is that AD is not just a scientific problem; it is associated with major psychosocial and ethical dilemmas and has a negative impact on national economies. The neurodegenerative process that occurs in AD involves a specific nervous cell dysfunction, which leads to neuronal death. Mutations in APP, PS1, and PS2 genes are causes for early onset AD. Several animal models have demonstrated that alterations in these proteins are able to induce oxidative damage, which in turn favors the development of AD. This paper provides a review of many, although not all, of the mutations present in patients with familial Alzheimer's disease and the association between some of these mutations with both oxidative damage and the development of the pathology.
authors.affiliation: Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Instituto Politécnico Nacional 2508, 07360 Mexico City, Mexico.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Meraz-Ríos
authors.affiliation: Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Universidad 3000, Coyoacan, 04510 Mexico City, Mexico.
authors.forename: Diana
authors.initials: D
authors.lastname: Franco-Bocanegra
authors.affiliation: Departamento de Fisiología Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Instituto Politécnico Nacional 2508, 07360 Mexico City, Mexico.
authors.forename: Danira
authors.initials: D
authors.lastname: Toral Rios
authors.affiliation: Laboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Insurgentes Sur 3877, 14269 Mexico City, Mexico.
authors.forename: Victoria
authors.initials: V
authors.lastname: Campos-Peña
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000235:genetics; D006801:Humans; D016874:Neurofibrillary Tangles / Q000473:pathology; D018384:Oxidative Stress; D058225:Plaque, Amyloid / Q000150:complications / Q000473:pathology; D053763:Presenilins / Q000235:genetics
chemical_list: D016229:Amyloid beta-Peptides; D053763:Presenilins