title: Hypertriglyceridemia and low high-density lipoprotein cholesterolemia are associated with increased hazard for urolithiasis.
abstract: OBJECTIVE
  To assess the association between dyslipidemia and urolithiasis, a propensity score-matching study was performed.
  
  
  METHODS
  Fasting blood samples were taken, and serum lipid profiles were measured in 655 stone formers (SF) and 1965 propensity score-matched controls between 2005 and 2011. The controls, from a health-screening program, did not have a history of dyslipidemia or statin use and have any evidence of stone disease, as determined by abdominal radiography, ultrasonography examination. Propensity score-matching with respect to age, sex, and body mass index was used to minimize selection bias, and the logistic regression analysis was adjusted for other components of metabolic syndrome.
  
  
  RESULTS
  Compared with controls, the SF group had significantly higher mean triglyceride and lower total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels (each P<0.001). The SF group was also more likely to have hypertriglyceridemia and low HDL-cholesterolemia, and less likely to have hypercholesterolemia and high LDL cholesterolemia compared with controls (each P<0.05). When adjusted for other components of metabolic syndrome including obesity, presence of diabetes mellitus or hypertension, the odds ratio (OR) for urinary stones appeared with hypercholesterolemia (OR=0.747, P=0.003), hypertriglyceridemia (OR=1.901, P<0.001), low HDL cholesterolemia (OR=1.886, P<0.001) and high LDL cholesterolemia (OR=0.610, P<0.001).
  
  
  CONCLUSIONS
  Our study implies that dyslipidemia may play a crucial part in urinary stone risk.
authors.affiliation: Department of Urology, Chungbuk National University , College of Medicine and Institute for Tumor Research, Cheongju, South Korea .
authors.forename: Ho Won
authors.initials: HW
authors.lastname: Kang
authors.forename: Sang Keun
authors.initials: SK
authors.lastname: Lee
authors.forename: Won Tae
authors.initials: WT
authors.lastname: Kim
authors.forename: Yong-June
authors.initials: YJ
authors.lastname: Kim
authors.forename: Seok-Joong
authors.initials: SJ
authors.lastname: Yun
authors.forename: Sang-Cheol
authors.initials: SC
authors.lastname: Lee
authors.forename: Wun-Jae
authors.initials: WJ
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000150:complications*; D007009:Hypolipoproteinemias / Q000150:complications*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D057216:Propensity Score; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D052878:Urolithiasis / Q000188:drug therapy / Q000209:etiology*; D055815:Young Adult
chemical_list: D008075:Lipoproteins, HDL; D002784:Cholesterol