title: [Impact of surgery in the management of pancreatic metastases of renal cell cancer].
abstract: BACKGROUND
  Incidence of renal cell carcinoma (RCC) is increasing over the 25 last years. Pancreatic metastases of RCC are rare. The aim of this work was to study overall survival of patients operated for pancreatic metastases of RCC in Montpellier cancer institute.
  
  
  METHODS
  Between 2000 and 2012, a retrospective monocentric study was performed at Montpellier cancer institute. We evaluated the outcomes of curative pancreatic metastases from renal primary and the impact of targeted therapies.
  
  
  RESULTS
  Thirty-eight patients were treated in our center for pancreatic metastases of RCC. Twelve patients had a curative surgery of metachronous pancreatic metastases. Four patients were without recurrence after pancreatic resection (33.3%). None had adjuvant therapy. Six patients were treated by targeted therapies, because of metastatic progression. Five of 6 died, the sixth evolved with targeted therapies by thyrosine kinase inhibitor. Average deadline between appearance of metastases and death was 89.9 months for operated patients. Average deadline between appearance of c metastases and death was 33.1 months for the others (P=0.004).
  
  
  CONCLUSIONS
  Surgical treatment of pancreatic metastases should increase life expectancy of patients. Others studies are necessary to prove the impact of targeted therapies in metastatics patients in this indication.
  
  
  METHODS
  5.
authors.affiliation: Institut du cancer de Montpellier (ICM), 208, avenue des Apothicaires, 34298 Montpellier cedex 5, France. Electronic address: j.bertrand06@laposte.net.
authors.forename: J
authors.initials: J
authors.lastname: Bertrand
authors.affiliation: Institut du cancer de Montpellier (ICM), 208, avenue des Apothicaires, 34298 Montpellier cedex 5, France.
authors.forename: B
authors.initials: B
authors.lastname: Saint-Aubert
authors.affiliation: Institut du cancer de Montpellier (ICM), 208, avenue des Apothicaires, 34298 Montpellier cedex 5, France.
authors.forename: E
authors.initials: E
authors.lastname: Joly
authors.affiliation: Institut du cancer de Montpellier (ICM), 208, avenue des Apothicaires, 34298 Montpellier cedex 5, France.
authors.forename: C
authors.initials: C
authors.lastname: Philippe
authors.affiliation: Institut du cancer de Montpellier (ICM), 208, avenue des Apothicaires, 34298 Montpellier cedex 5, France.
authors.forename: F
authors.initials: F
authors.lastname: Quenet
authors.affiliation: Institut du cancer de Montpellier (ICM), 208, avenue des Apothicaires, 34298 Montpellier cedex 5, France.
authors.forename: S
authors.initials: S
authors.lastname: Carrere
authors.affiliation: Institut du cancer de Montpellier (ICM), 208, avenue des Apothicaires, 34298 Montpellier cedex 5, France.
authors.forename: P
authors.initials: P
authors.lastname: Rouanet
authors.affiliation: Institut du cancer de Montpellier (ICM), 208, avenue des Apothicaires, 34298 Montpellier cedex 5, France.
authors.forename: J
authors.initials: J
authors.lastname: Domergue
mesh_terms: D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D047428:Protein Kinase Inhibitors
keywords: Cancer du rein; Chirurgie; Métastases pancréatiques; Pancreatic metastases; Renal cell cancer; Surgery; Targeted therapies; Thérapies ciblées