title: New perspectives for transcatheter aortic valve implantation: more than a "simple" alternative to surgery.
abstract: To date, the gold standard of aortic stenosis treatment is surgical valve replacement. However, in inoperable or high risk patients a valid alternative is transcatheter aortic valve implantation (TAVI). Several trials showed feasibility, efficacy and safety of TAVI, with a tailored strategy for these patients on the basis of their clinical and anatomical conditions. The selection of valve type (CoreValve® or Edwards Sapien®) and transcatheter approach (transfemoral, transapical, subclavian or direct aortic approach) is an important step in the management of aortic stenosis. However, mortality is high and it is mainly related to non-cardiac reasons, given the high clinical risk profile of these patients. Moreover, the less invasive approach, the faster recovery, the reduced morbidity and the improved psychological tolerance, typical of TAVI, suggest that this technique could be used in a broader spectrum of cases, becoming a valid therapeutic alternative even in patients with severe aortic stenosis with a low surgical risk or asymptomatics. The identification of aortic stenosis patients by the medical community and their assessment over time, before they become candidates only for "extreme" strategies, remains the main challenge.
authors.affiliation: Department of Advanced Biomedical Sciences Federico II University, Naples, Italy - gengalas@unina.it.
authors.forename: T
authors.initials: T
authors.lastname: Niglio
authors.forename: G
authors.initials: G
authors.lastname: Galasso
authors.forename: R
authors.initials: R
authors.lastname: Piccolo
authors.forename: G
authors.initials: G
authors.lastname: Di Gioia
authors.forename: T
authors.initials: T
authors.lastname: Strisciuglio
authors.forename: G
authors.initials: G
authors.lastname: Esposito
authors.forename: B
authors.initials: B
authors.lastname: Trimarco
authors.forename: F
authors.initials: F
authors.lastname: Piscione
mesh_terms: D001024:Aortic Valve Stenosis / Q000503:physiopathology / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006801:Humans; D012307:Risk Factors; D012720:Severity of Illness Index; D065467:Transcatheter Aortic Valve Replacement / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*