title: [Advances in the relationship between microRNA and cisplatin resistance of lung cancer].
abstract: MicroRNAs (miRNAs) are a class of small, about 22 nucleotides endogenous noncoding RNAs that negatively regulate their target genes' expression through post-transcriptional suppression. MicroRNA has a broad effect on tumorigenesis and tumor biological processes, including tumor development, differentiation, metastasis and chemoresistance. Chemoresistance represents a major obstacle in effective clinical treatment of tumors, how to conquer the chemoresistance in tumor arouses people's interst. A growing number of studies have proved that microRNAs play a crucial role in tumor chemoresistance. This view will discuss the the progress research between microRNA and tumor therapy, especially the cisplatin chemotherapy in tumor.
authors.affiliation: Tianjin Medical University, Tianjin 300070, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenviroment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenviroment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D035683:MicroRNAs; D002945:Cisplatin