title: Metastatic hepatic epithelioid hemangio-endothelioma: long-term response to sunitinib malate.
abstract: BACKGROUND
  Epithelioid hemangio-endothelioma (EHE) is a rare malignant tumor of vascular origin that electively metastasizes to lungs and liver.
  
  
  METHODS
  We report the case of a 51-year-old woman with metastatic and progressive EHE of the liver. She was successfully treated with daily administration of sunitinib malate, an oral multi-target tyrosine kinase inhibitor, which particularly targets vascular endothelial growth factor (VEGF) receptors. Stabilization has lasted 6 years. We discuss the rationale for using antiangiogenic treatment for EHE.
  
  
  CONCLUSIONS
  This case adds to a growing body of evidence that suggests that antiangiogenic agents should be considered in patients who present with advanced EHE.
authors.affiliation: Department of Medical Oncology, Centre Antoine Lacassagne, Nice, France.
authors.forename: Esma
authors.initials: E
authors.lastname: Saada
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Saint Paul
authors.forename: Jean
authors.initials: J
authors.lastname: Gugenheim
authors.forename: Philippe
authors.initials: P
authors.lastname: Follana
authors.forename: Eric
authors.initials: E
authors.lastname: François
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D006801:Humans; D007211:Indoles / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D008137:Longitudinal Studies; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000473:pathology; D011758:Pyrroles / Q000008:administration & dosage*; D000077210:Sunitinib; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib