title: Povidone iodine in the treatment of adenoviral conjunctivitis in infants.
abstract: BACKGROUND
  Adenoviral conjunctivitis.
  
  
  OBJECTIVE
  To examine the effects of conjunctival irrigation with povidone iodine in infants with adenoviral conjunctivitis.
  
  
  METHODS
  An outbreak of adenovirus conjunctivitis occurred between September and December 2012 at the neonatal intensive care unit of our hospital. Forty-three infants with adenoviral conjunctivitis were examined in this study. Thirty-five eyes of 35 infants who had detailed ophthalmological examination and clinical scoring were included. The conjunctiva of 15 infants (Group 1) were irrigated with povidone iodine 2.5% solution and then treated with preservative-free artificial tears and preservative-free antibiotic drops. Twenty infants (Group 2) were treated only with the same drops with the same posology, without conjunctival irrigation with povidone iodine. Patients were examined two times a week until the complete recovery. Lid edema, conjunctival chemosis, fragility of conjunctival vasculature, pseudomembrane formation, and corneal involvement were scored clinically.
  
  
  RESULTS
  Twenty patients (57%) were female and 15 patients (43%) were male and mean age was 3.1 months (ranged from 1 to 4 months). No relation was found between gender and clinical scores. Statistically significant lower clinical scores were obtained from Group 1. The median recovery time was earlier in Group 1 (7 d) than Group 2 (12 d) (p = 0.001).
  
  
  CONCLUSIONS
  Conjunctival irrigation with 2.5% povidone iodine is effective in the treatment of adenoviral conjunctivitis in infants.
authors.affiliation: Department of Ophthalmology, Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey and.
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Özen Tunay
authors.forename: Ozdemir
authors.initials: O
authors.lastname: Ozdemir
authors.forename: Ikbal Seza
authors.initials: IS
authors.lastname: Petricli
mesh_terms: D000257:Adenoviridae Infections / Q000188:drug therapy* / Q000453:epidemiology; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D003236:Conjunctivitis, Viral / Q000188:drug therapy* / Q000453:epidemiology; D003428:Cross Infection / Q000188:drug therapy* / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007223:Infant; D015931:Intensive Care, Neonatal; D008297:Male; D011206:Povidone-Iodine / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine
keywords: Adenovirus; epidemic keratoconjunctivitis; infants; povidone iodine; pseudomembrane