title: Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events.
abstract: OBJECTIVE
  Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD).
  
  
  METHODS
  The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A; N = 2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B; N = 3548 cases, 5972 controls).
  
  
  RESULTS
  In study A, the prevalence of hypertension, diabetes and >50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p = 0.030; odds ratio = 1.29 [95% confidence interval 1.03‒1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke.
  
  
  CONCLUSIONS
  The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography.
authors.affiliation: School of Medicine, University of Tampere, Tampere, Finland; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Electronic address: kari-matti.makela@uta.fi.
authors.forename: Kari-Matti
authors.initials: KM
authors.lastname: Mäkelä
authors.affiliation: Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom.
authors.forename: Matthew
authors.initials: M
authors.lastname: Traylor
authors.affiliation: School of Medicine, University of Tampere, Tampere, Finland; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Division of Vascular Surgery, Department of Surgery, Tampere University Hospital, Tampere, Finland.
authors.forename: Niku
authors.initials: N
authors.lastname: Oksala
authors.affiliation: Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Germany.
authors.forename: Marcus E
authors.initials: ME
authors.lastname: Kleber
authors.affiliation: School of Medicine, University of Tampere, Tampere, Finland; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
authors.forename: Ilkka
authors.initials: I
authors.lastname: Seppälä
authors.affiliation: School of Medicine, University of Tampere, Tampere, Finland; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
authors.forename: Leo-Pekka
authors.initials: LP
authors.lastname: Lyytikäinen
authors.affiliation: School of Medicine, University of Tampere, Tampere, Finland; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Internal Medicine, North Karelia Central Hospital, Joensuu, Finland.
authors.forename: Jussi A
authors.initials: JA
authors.lastname: Hernesniemi
authors.affiliation: Department of Clinical Physiology, Tampere University Hospital and University of Tampere, Tampere, Finland.
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
authors.affiliation: Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: Steve
authors.initials: S
authors.lastname: Bevan
authors.affiliation: Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Rothwell
authors.affiliation: Division of Clinical Neurosciences and Insititute of Genetics and Molecular Medicine, University of Edinburgh, UK.
authors.forename: Cathie
authors.initials: C
authors.lastname: Sudlow
authors.affiliation: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Dichgans
authors.affiliation: Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Germany.
authors.forename: Graciela
authors.initials: G
authors.lastname: Delgado
authors.affiliation: Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Germany.
authors.forename: Tanja B
authors.initials: TB
authors.lastname: Grammer
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz, Graz, Austria.
authors.forename: Hubert
authors.initials: H
authors.lastname: Scharnagl
authors.affiliation: Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: Hugh S
authors.initials: HS
authors.lastname: Markus
authors.affiliation: Synlab Services GmbH, Mannheim, Germany; Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz, Graz, Austria.
authors.forename: Winfried
authors.initials: W
authors.lastname: März
authors.affiliation: School of Medicine, University of Tampere, Tampere, Finland; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
mesh_terms: D002545:Brain Ischemia / Q000097:blood / Q000150:complications / Q000235:genetics; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000235:genetics*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood* / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000097:blood / Q000209:etiology / Q000235:genetics
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein
keywords: Genetics; Oxidized low-density lipoprotein; Single nucleotide polymorphism; Stroke; Transient ischaemic attack