title: Raman spectroscopy in the analysis of food and pharmaceutical nanomaterials.
abstract: Raman scattering is an inelastic phenomenon. Although its cross section is very small, recent advances in electronics, lasers, optics, and nanotechnology have made Raman spectroscopy suitable in many areas of application. The present article reviews the applications of Raman spectroscopy in food and drug analysis and inspection, including those associated with nanomaterials. Brief overviews of basic Raman scattering theory, instrumentation, and statistical data analysis are also given. With the advent of Raman enhancement mechanisms and the progress being made in metal nanomaterials and nanoscale metal surfaces fabrications, surface enhanced Raman scattering spectroscopy has become an extra sensitive method, which is applicable not only for analysis of foods and drugs, but also for intracellular and intercellular imaging. A Raman spectrometer coupled with a fiber optics probe has great potential in applications such as monitoring and quality control in industrial food processing, food safety in agricultural plant production, and convenient inspection of pharmaceutical products, even through different types of packing. A challenge for the routine application of surface enhanced Raman scattering for quantitative analysis is reproducibility. Success in this area can be approached with each or a combination of the following methods: (1) fabrication of nanostructurally regular and uniform substrates; (2) application of statistic data analysis; and (3) isotopic dilution.
authors.affiliation: Department of Chemistry, University of Memphis, Memphis, TN 38152, USA. Electronic address: Yingli@memphis.edu.
authors.forename: Ying-Sing
authors.initials: YS
authors.lastname: Li
authors.affiliation: CSIRO Materials Science and Engineering, PO Box 21, Belmont, VIC 3216, Australia.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Church
mesh_terms: D000818:Animals; D005504:Food Analysis / Q000379:methods; D005506:Food Contamination / Q000032:analysis; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry / Q000592:standards; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods
chemical_list: D004364:Pharmaceutical Preparations
keywords: Food; Nanomaterials; Pharmaceuticals; Raman cell imaging; Raman spectroscopy