title: Segmenting the papillary muscles and the trabeculae from high resolution cardiac CT through restoration of topological handles.
abstract: We introduce a novel algorithm for segmenting the high resolution CT images of the left ventricle (LV), particularly the papillary muscles and the trabeculae. High quality segmentations of these structures are necessary in order to better understand the anatomical function and geometrical properties of LV. These fine structures, however, are extremely challenging to capture due to their delicate and complex nature in both geometry and topology. Our algorithm computes the potential missing topological structures of a given initial segmentation. Using techniques from computational topology, e.g. persistent homology, our algorithm find topological handles which are likely to be the true signal. To further increase accuracy, these proposals are measured by the saliency and confidence from a trained classifier. Handles with high scores are restored in the final segmentation, leading to high quality segmentation results of the complex structures.
authors.forename: Mingchen
authors.initials: M
authors.lastname: Gao
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Shaoting
authors.initials: S
authors.lastname: Zhang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Qian
authors.forename: Dimitris
authors.initials: D
authors.lastname: Metaxas
authors.forename: Leon
authors.initials: L
authors.lastname: Axel
mesh_terms: D000465:Algorithms; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D010210:Papillary Muscles / Q000000981:diagnostic imaging*; D010363:Pattern Recognition, Automated / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*