title: A novel vacuum assisted closure therapy model for use with percutaneous devices.
abstract: Long-term maintenance of a dermal barrier around a percutaneous prosthetic device remains a common clinical problem. A technique known as Negative Pressure Wound Therapy (NPWT) uses negative pressure to facilitate healing of impaired and complex soft tissue wounds. However, the combination of using negative pressure with percutaneous prosthetic devices has not been investigated. The goal of this study was to develop a methodology to apply negative pressure to the tissues surrounding a percutaneous device in an animal model; no tissue healing outcomes are presented. Specifically, four hairless rats received percutaneous porous coated titanium devices implanted on the dorsum and were bandaged with a semi occlusive film dressing. Two of these animals received NPWT; two animals received no NPWT and served as baseline controls. Over a 28-day period, both the number of dressing changes required between the two groups as well as the pressures were monitored. Negative pressures were successfully applied to the periprosthetic tissues in a clinically relevant range with a manageable number of dressing changes. This study provides a method for establishing, maintaining, and quantifying controlled negative pressures to the tissues surrounding percutaneous devices using a small animal model.
authors.affiliation: Orthopaedic Research Laboratory, University of Utah Orthopaedic Center, Salt Lake City, UT 84108, USA; Bone and Joint Research Laboratory, Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA.
authors.forename: Saranne J
authors.initials: SJ
authors.lastname: Cook
authors.affiliation: Orthopaedic Research Laboratory, University of Utah Orthopaedic Center, Salt Lake City, UT 84108, USA; Bone and Joint Research Laboratory, Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA.
authors.forename: Francesca R
authors.initials: FR
authors.lastname: Nichols
authors.affiliation: Bone and Joint Research Laboratory, Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA.
authors.forename: Lucille B
authors.initials: LB
authors.lastname: Brunker
authors.affiliation: Orthopaedic Research Laboratory, University of Utah Orthopaedic Center, Salt Lake City, UT 84108, USA; Bone and Joint Research Laboratory, Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA; Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: kent.bachus@hsc.utah.edu.
authors.forename: Kent N
authors.initials: KN
authors.lastname: Bachus
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006799:Housing, Animal; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D009779:Occlusive Dressings; D011312:Pressure; D019736:Prostheses and Implants; D054772:Rats, Hairless; D012867:Skin / Q000293:injuries* / Q000503:physiopathology; D014025:Titanium; D016896:Treatment Outcome; D014618:Vacuum; D014945:Wound Healing
chemical_list: D014025:Titanium
keywords: Animal model; Hairless rat; Negative-pressure wound therapy; Percutaneous device; Skin; Wound healing