title: Midazolam and drug-drug interactions in dental conscious sedation.
abstract: Careful prescribing is paramount in clinical practice. Potential drug-drug interactions need to be considered. Midazolam is the drug of choice for the purpose of IV sedation. To ensure safe clinical practice, the patient's current medications need to be recorded.
  
  
  CONCLUSIONS
  An update on the drug interactions relating to midazolam are worthy of scrutiny as its use becomes more commonplace in clinical practice.
  
  
  OBJECTIVE
  The dentist should understand the possible implications for drug interactions when sedating patients using midazolam.
authors.forename: Damian
authors.initials: D
authors.lastname: Broderick
authors.forename: Mary
authors.initials: M
authors.lastname: Clarke
authors.forename: Leo
authors.initials: L
authors.lastname: Stassen
mesh_terms: D000766:Anesthesia, Dental; D000771:Anesthesia, Intravenous; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000924:Anticholesteremic Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D016292:Procedural Sedation / Q000379:methods*; D051544:Cytochrome P-450 CYP3A; D065692:Cytochrome P-450 CYP3A Inhibitors; D004347:Drug Interactions; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000494:pharmacology; D008874:Midazolam / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000924:Anticholesteremic Agents; D000935:Antifungal Agents; D000959:Antihypertensive Agents; D065692:Cytochrome P-450 CYP3A Inhibitors; D006993:Hypnotics and Sedatives; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D008874:Midazolam