title: The interaction of a single-nucleotide polymorphism with age on response to interferon-α and ribavirin therapy in female patients with hepatitis C infection.
abstract: Older female patients exhibit a poor response to the current standard treatment for hepatitis C, interferon-α, and ribavirin (PEG-IFN-α/RBV). In this study, we reported that the combination of age and the genotype of a novel SNP can predict response to standard treatment (P = 7.31 × 10(-8)). The model incorporating genotype of the novel SNP, rs1287948, predicts response more accurately (AUC = 0.934; 95% CI = 0.881-0.988) in women as compared with the model using age and the previously identified SNP, rs8099917.
authors.affiliation: Center for Information Biology, National Institute of Genetics, Mishima, Japan.
authors.forename: Jo
authors.initials: J
authors.lastname: Nishino
authors.forename: Masaya
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Nao
authors.initials: N
authors.lastname: Nishida
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Masashi
authors.initials: M
authors.lastname: Mizokami
authors.forename: Shuhei
authors.initials: S
authors.lastname: Mano
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012254:Ribavirin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D016898:Interferon-alpha; D012254:Ribavirin
keywords: SNP; hepatitis C; interaction with age; prediction; response to treatment