title: Anti-hyperglycemic and anti-oxidative activities of ginseng polysaccharides in STZ-induced diabetic mice.
abstract: Neutral (WGPN) and acidic (WGPA) polysaccharides were fractionated from ginseng polysaccharide. WGPN and WGPA decreased fasting blood glucose by different manners of administration. Intra-gastric administration of WGPA showed a marked hypoglycemic effect, which may be related to its anti-oxidative activity. The results indicated that WGPA may have anti-diabetic potential.
authors.affiliation: Jilin Province Key Laboratory on Chemistry and Biology of Changbai Mountain Natural Drugs, School of Life Sciences, Northeast Normal University, Changchun 130024, PR China. zhouyf383@nenu.edu.cn.
authors.forename: Chengxin
authors.initials: C
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Xinzhi
authors.initials: X
authors.lastname: Li
authors.forename: Guihua
authors.initials: G
authors.lastname: Tai
authors.forename: Yuying
authors.initials: Y
authors.lastname: Fan
authors.forename: Yifa
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018384:Oxidative Stress / Q000187:drug effects; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D011134:Polysaccharides / Q000008:administration & dosage*
chemical_list: D007004:Hypoglycemic Agents; D010936:Plant Extracts; D011134:Polysaccharides