title: Nature's lab for derivatization: new and revised structures of a variety of streptophenazines produced by a sponge-derived Streptomyces strain.
abstract: Eight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I-K) also showed moderate activities against PDE 4B.
authors.affiliation: Kiel Center for Marine Natural Products at the Helmholtz Center for Ocean Research (GEOMAR), Am Kiel-Kanal 44, Kiel 24106, Germany. akunz@geomar.de.
authors.forename: Anna Lena
authors.initials: AL
authors.lastname: Kunz
authors.affiliation: Kiel Center for Marine Natural Products at the Helmholtz Center for Ocean Research (GEOMAR), Am Kiel-Kanal 44, Kiel 24106, Germany. alabes@geomar.de.
authors.forename: Antje
authors.initials: A
authors.lastname: Labes
authors.affiliation: Kiel Center for Marine Natural Products at the Helmholtz Center for Ocean Research (GEOMAR), Am Kiel-Kanal 44, Kiel 24106, Germany. jwiese@geomar.de.
authors.forename: Jutta
authors.initials: J
authors.lastname: Wiese
authors.affiliation: Institute of Organic Chemistry, University of Wuerzburg, Am Hubland, Wuerzburg 97074, Germany. torsten.bruhn@uni-wuerzburg.de.
authors.forename: Torsten
authors.initials: T
authors.lastname: Bruhn
authors.affiliation: Institute of Organic Chemistry, University of Wuerzburg, Am Hubland, Wuerzburg 97074, Germany. bringman@chemie.uni-wuerzburg.de.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Bringmann
authors.affiliation: Kiel Center for Marine Natural Products at the Helmholtz Center for Ocean Research (GEOMAR), Am Kiel-Kanal 44, Kiel 24106, Germany. jimhoff@geomar.de.
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D005285:Fermentation; D009792:Oceans and Seas; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011161:Porifera / Q000382:microbiology*; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D010619:Phenazines