title: Rho'ing in and out of cells: viral interactions with Rho GTPase signaling.
abstract: Rho GTPases are key regulators of actin and microtubule dynamics and organization. Increasing evidence shows that many viruses have evolved diverse interactions with Rho GTPase signaling and manipulate them for their own benefit. In this review, we discuss how Rho GTPase signaling interferes with many steps in the viral replication cycle, especially entry, replication, and spread. Seen the diversity between viruses, it is not surprising that there is considerable variability in viral interactions with Rho GTPase signaling. However, several largely common effects on Rho GTPases and actin architecture and microtubule dynamics have been reported. For some of these processes, the molecular signaling and biological consequences are well documented while for others we just begin to understand them. A better knowledge and identification of common threads in the different viral interactions with Rho GTPase signaling and their ultimate consequences for virus and host may pave the way toward the development of new antiviral drugs that may target different viruses.
authors.affiliation: Department of Virology, Parasitology, and Immunology; Faculty of Veterinary Medicine; Ghent University; Ghent, Belgium.
authors.forename: Céline
authors.initials: C
authors.lastname: Van den Broeke
authors.affiliation: Department of Virology, Parasitology, and Immunology; Faculty of Veterinary Medicine; Ghent University; Ghent, Belgium.
authors.forename: Thary
authors.initials: T
authors.lastname: Jacob
authors.affiliation: Department of Virology, Parasitology, and Immunology; Faculty of Veterinary Medicine; Ghent University; Ghent, Belgium.
authors.forename: Herman W
authors.initials: HW
authors.lastname: Favoreel
mesh_terms: D000199:Actins / Q000378:metabolism; D002966:Clathrin / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D004705:Endocytosis; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D014780:Viruses / Q000378:metabolism / Q000472:pathogenicity; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D000199:Actins; D002966:Clathrin; D020741:rho GTP-Binding Proteins
keywords: Rho GTPase; actin; egress; entry; gene expression; immune system; transformation; virus