title: Association study of ARL15 and CDH13 with T2DM in a Han Chinese population.
abstract: Several studies indicate that plasma adiponectin levels are associated with the risk of type 2 diabetes mellitus (T2DM) or T2DM risk factors in diverse populations. In addition to the adiponectin gene, several other genes have been postulated to influence plasma adiponectin levels. In this study, we investigated two single nucleotide polymorphisms (SNPs), rs4311394 and rs4783244, located intronically in the ADP-ribosylation factor-like protein 15 (ARL15) and the T-cadherin (CDH13) genes, respectively. These SNPs were detected in a Han Chinese population using a TaqMan assay and evaluated for association with T2DM as well as with individual metabolic traits. Allele frequencies for rs4311394 were significantly different in T2DM and nondiabetes (NDM) groups (χ² = 4.49, P = 0.034). However, neither allele nor genotype frequencies for rs4783244 were associated with T2DM (χ² = 0.33, P = 0.56 and χ² = 2.35, P = 0.31 respectively). The SNPs did not exhibit significant association with individual metabolic traits in the T2DM and NDM groups. Our results indicated that the G allele of the rs4311394 might be a susceptibility factor for T2DM in the Han Chinese population (odds ratio: 1.20; 95% confidence interval: 1.01-1.41).
authors.affiliation: 1. School of Medicine, Yunnan University, Kunming 650091, Yunnan, China; ; 2. Department of Endocrinology and Metabolism, The Second People's Hospital of Yunnan Province, Kunming 650021, Yunnan, China;
authors.forename: Yiping
authors.initials: Y
authors.lastname: Li
authors.affiliation: 2. Department of Endocrinology and Metabolism, The Second People's Hospital of Yunnan Province, Kunming 650021, Yunnan, China;
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.affiliation: 3. Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China.
authors.forename: Yueting
authors.initials: Y
authors.lastname: Yao
authors.affiliation: 2. Department of Endocrinology and Metabolism, The Second People's Hospital of Yunnan Province, Kunming 650021, Yunnan, China;
authors.forename: Xianli
authors.initials: X
authors.lastname: Li
authors.affiliation: 3. Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shi
authors.affiliation: 2. Department of Endocrinology and Metabolism, The Second People's Hospital of Yunnan Province, Kunming 650021, Yunnan, China;
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 2. Department of Endocrinology and Metabolism, The Second People's Hospital of Yunnan Province, Kunming 650021, Yunnan, China;
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: 2. Department of Endocrinology and Metabolism, The Second People's Hospital of Yunnan Province, Kunming 650021, Yunnan, China;
authors.forename: Man
authors.initials: M
authors.lastname: Yan
authors.affiliation: 3. Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Yao
authors.affiliation: 1. School of Medicine, Yunnan University, Kunming 650091, Yunnan, China;
authors.forename: Chunjie
authors.initials: C
authors.lastname: Xiao
mesh_terms: D020727:ADP-Ribosylation Factors / Q000235:genetics*; D000483:Alleles; D015820:Cadherins / Q000235:genetics*; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000473:pathology; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D015820:Cadherins; C099972:H-cadherin; D020727:ADP-Ribosylation Factors; C585870:ARL15 protein, human
keywords: ARL15; CDH13.; Chinese population; SNP; T2DM