title: KRAS and KIT Gatekeeper Mutations Confer Polyclonal Primary Imatinib Resistance in GI Stromal Tumors: Relevance of Concomitant Phosphatidylinositol 3-Kinase/AKT Dysregulation.
authors.affiliation: Brigham and Women's Hospital; Ludwig Center at Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.
authors.forename: César
authors.initials: C
authors.lastname: Serrano
authors.affiliation: Brigham and Women's Hospital, Boston, MA.
authors.forename: Yuexiang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Brigham and Women's Hospital, Boston, MA.
authors.forename: Adrián
authors.initials: A
authors.lastname: Mariño-Enríquez
authors.affiliation: Brigham and Women's Hospital, Boston, MA; National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Jen-Chieh
authors.initials: JC
authors.lastname: Lee
authors.affiliation: Brigham and Women's Hospital, Boston, MA; University of Bologna, Bologna, Italy.
authors.forename: Gloria
authors.initials: G
authors.lastname: Ravegnini
authors.affiliation: Ludwig Center at Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Morgan
authors.affiliation: Brigham and Women's Hospital, Boston, MA.
authors.forename: Monica M
authors.initials: MM
authors.lastname: Bertagnolli
authors.affiliation: Portland Veterans Affairs Medical Center and Knight Cancer Institute, Oregon Health and Science University, Portland, OR.
authors.forename: Carol
authors.initials: C
authors.lastname: Beadling
authors.affiliation: Ludwig Center at Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.
authors.forename: George D
authors.initials: GD
authors.lastname: Demetri
authors.affiliation: Knight Cancer Institute, Oregon Health and Science University, Portland, OR.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Corless
authors.affiliation: Portland Veterans Affairs Medical Center and Knight Cancer Institute, Oregon Health and Science University, Portland, OR.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Heinrich
authors.affiliation: Brigham and Women's Hospital; Ludwig Center at Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA jfletcher@partners.org.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Fletcher
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001120:Arginine; D001549:Benzamides / Q000008:administration & dosage / Q000494:pharmacology*; D002277:Carcinoma / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000235:genetics*; D005998:Glycine; D006801:Humans; D000068877:Imatinib Mesylate; D007532:Isoleucine; D008297:Male; D008875:Middle Aged; D009154:Mutation; D058539:Phosphatidylinositol 3-Kinase / Q000378:metabolism*; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D017422:Sequence Analysis, DNA; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000235:genetics*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D013912:Threonine; D013997:Time Factors; D018631:ras Proteins / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; C117307:KRAS protein, human; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011518:Proto-Oncogene Proteins; D011743:Pyrimidines; D007532:Isoleucine; D013912:Threonine; D000068877:Imatinib Mesylate; D001120:Arginine; C546842:MTOR protein, human; D058539:Phosphatidylinositol 3-Kinase; D019009:Proto-Oncogene Proteins c-kit; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins; D005998:Glycine