title: Organocatalytic approach for C(sp3)-H bond arylation, alkylation, and amidation of isochromans under facile conditions.
abstract: A new catalytic approach for the synthesis of isochroman derivatives via direct C(sp(3))-H bond arylation is described. The oxidation reaction with [bis(trifluoroacetoxy)iodo]benzene facilitates the regeneration of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in the C(sp(3))-H bond arylation of isochroman. The reaction conditions can also be used for alkyl Grignard reagents and amides to afford the corresponding isochroman derivatives.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University , 1-14 Bunkyo-machi, Nagasaki, Nagasaki 852-8521, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Muramatsu
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Nakano
mesh_terms: D000478:Alkylation; D000577:Amides / Q000737:chemistry; D016227:Benzoquinones / Q000737:chemistry; D002384:Catalysis; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000577:Amides; D016227:Benzoquinones; D002839:Chromans; D007202:Indicators and Reagents; C000928:dichlorodicyanobenzoquinone