title: The biogenesis of chromosome translocations.
abstract: Chromosome translocations are catastrophic genomic events and often play key roles in tumorigenesis. Yet the biogenesis of chromosome translocations is remarkably poorly understood. Recent work has delineated several distinct mechanistic steps in the formation of translocations, and it has become apparent that non-random spatial genome organization, DNA repair pathways and chromatin features, including histone marks and the dynamic motion of broken chromatin, are critical for determining translocation frequency and partner selection.
authors.affiliation: National Cancer Institute, Bethesda, Maryland 20892, USA.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Roukos
authors.affiliation: National Cancer Institute, Bethesda, Maryland 20892, USA.
authors.forename: Tom
authors.initials: T
authors.lastname: Misteli
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002843:Chromatin / Q000235:genetics; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000235:genetics*; D006657:Histones / Q000235:genetics; D006801:Humans; D051379:Mice; D059645:Mutation Rate; D012441:Saccharomyces cerevisiae / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D002843:Chromatin; D006657:Histones