title: Health status, function, productivity, and costs among individuals with idiopathic painful peripheral neuropathy with small fiber involvement in the United States: results from a retrospective chart review and cross-sectional survey.
abstract: OBJECTIVE
  To characterize the burden of idiopathic painful peripheral neuropathy with small fiber involvement (idiopathic SFN) by pain severity in the US.
  
  
  METHODS
  One hundred previously diagnosed idiopathic SFN subjects were enrolled during routine office visits. Subjects completed a one-time questionnaire, and investigators reported clinical characteristics and healthcare resource use, based on 6 month retrospective chart review. Annualized direct and indirect costs were estimated. Results were stratified across pain severity groups.
  
  
  RESULTS
  Mean age was 63.5 years; 53.0% were female; 76.0% had moderate or severe pain. Most common comorbidities were sleep disturbance/insomnia (37.0%), anxiety (34.0%), and depressive symptoms (33.0%). Overall mean health status (0.59; -0.11-1.00 scale), physical and mental health (31.7 and 45.6, respectively, 0-100 scale), sleep index (45.1; 0-100 scale), and pain interference with function (5.0; 0-10 scale) differed by pain severity, with worse outcomes among those with greater pain (all p < 0.002). 84.0% were prescribed ≥1 SFN medication. 16.0% were employed; mean overall work impairment was 36.9%. Annualized average adjusted direct and indirect costs per subject ($8055 and $13,733, respectively) differed by pain severity.
  
  
  CONCLUSIONS
  Idiopathic SFN subjects with pain experience moderate or severe pain, which negatively impacts health status, function, and productivity, and leads to substantial direct and indirect costs.
authors.affiliation: Covance Market Access Services Inc. , Gaithersburg, MD , USA.
authors.forename: Caroline
authors.initials: C
authors.lastname: Schaefer
authors.forename: Rachael
authors.initials: R
authors.lastname: Mann
authors.forename: Alesia
authors.initials: A
authors.lastname: Sadosky
authors.forename: Shoshana
authors.initials: S
authors.lastname: Daniel
authors.forename: Bruce
authors.initials: B
authors.lastname: Parsons
authors.forename: Srinivas
authors.initials: S
authors.lastname: Nalamachu
authors.forename: Brett R
authors.initials: BR
authors.lastname: Stacey
authors.forename: Michael
authors.initials: M
authors.lastname: Tuchman
authors.forename: Alan
authors.initials: A
authors.lastname: Anschel
authors.forename: Edward
authors.initials: E
authors.lastname: Nieshoff
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D017281:Cost of Illness; D003365:Costs and Cost Analysis; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D004526:Efficiency; D004916:Erythromelalgia / Q000191:economics* / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008603:Mental Health / Q000706:statistics & numerical data; D008875:Middle Aged; D010147:Pain Measurement; D011788:Quality of Life; D012189:Retrospective Studies; D012720:Severity of Illness Index
keywords: Burden; Costs; Function; Health status; Healthcare resource use; Idiopathic small fiber neuropathy; Neuropathic pain; Patient-reported outcomes; Productivity