title: Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice.
abstract: Prevention of quality of life (QOL) deterioration is associated with the inhibition of geriatric diseases and the regulation of brain function. However, no substance is known that prevents the aging of both body and brain. It is known that polyamine concentrations in somatic tissues (including the brain) decrease with increasing age, and polyamine-rich foods enhance longevity in yeast, worms, flies, and mice, and protect flies from age-induced memory impairment. A main source of exogenous polyamines is the intestinal lumen, where they are produced by intestinal bacteria. We found that arginine intake increased the concentration of putrescine in the colon and increased levels of spermidine and spermine in the blood. Mice orally administered with arginine in combination with the probiotic bifidobacteria LKM512 long-term showed suppressed inflammation, improved longevity, and protection from age-induced memory impairment. This study shows that intake of arginine and LKM512 may prevent aging-dependent declines in QOL via the upregulation of polyamines.
authors.affiliation: 1] Benno Laboratory, RIKEN Innovation center, Wako, Saitama 351-0198, Japan [2].
authors.forename: Ryoko
authors.initials: R
authors.lastname: Kibe
authors.affiliation: 1] Division of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto 606-8585, Japan [2] Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan [3] [4].
authors.forename: Shin
authors.initials: S
authors.lastname: Kurihara
authors.affiliation: Division of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Sakai
authors.affiliation: Division of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Human Metabolome Technologies Inc., Tsuruoka, Yamagata 997-0052, Japan.
authors.forename: Takushi
authors.initials: T
authors.lastname: Ooga
authors.affiliation: Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode, Nishitama, Tokyo 190-0182, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Sawaki
authors.affiliation: Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode, Nishitama, Tokyo 190-0182, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Muramatsu
authors.affiliation: Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode, Nishitama, Tokyo 190-0182, Japan.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Nakamura
authors.affiliation: Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode, Nishitama, Tokyo 190-0182, Japan.
authors.forename: Ayano
authors.initials: A
authors.lastname: Yamashita
authors.affiliation: Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode, Nishitama, Tokyo 190-0182, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kitada
authors.affiliation: Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Kakeyama
authors.affiliation: Benno Laboratory, RIKEN Innovation center, Wako, Saitama 351-0198, Japan.
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Benno
authors.affiliation: Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode, Nishitama, Tokyo 190-0182, Japan.
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Matsumoto
mesh_terms: D000284:Administration, Oral; D000375:Aging; D000818:Animals; D001120:Arginine / Q000008:administration & dosage; D005243:Feces / Q000737:chemistry; D005260:Female; D007422:Intestines / Q000382:microbiology*; D008136:Longevity; D008297:Male; D055442:Metabolome; D055432:Metabolomics; D051379:Mice; D064307:Microbiota; D011073:Polyamines / Q000097:blood / Q000378:metabolism*; D019936:Probiotics; D011700:Putrescine / Q000378:metabolism; D011788:Quality of Life; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D011073:Polyamines; D001120:Arginine; D011700:Putrescine