title: Resistin: a potential biomarker for periodontitis influenced diabetes mellitus and diabetes induced periodontitis.
abstract: Biomarkers are highly specific and sensitive indicators of disease activity. Resistin is a recently discovered adipocytokine, having a potent biomarker quality. Initially resistin was thought to be produced by adipocytes alone; however, emerging evidence suggests that it is also produced in abundance by various cells of the immunoinflammatory system, indicating its role in various chronic inflammatory diseases. Data suggests that resistin plays a role in obesity, insulin resistance, cardiovascular diseases, and periodontitis. Resistin derived its name from the original observation that it induced insulin resistance (resist-in: resist insulin) in mice and is downregulated in mature murine adipocytes cultured in the presence of insulin sensitizing drugs like thiazolidinediones. It is well recognized that obesity, is associated with insulin resistance and diabetes. A three-way relationship has been established between diabetes, obesity and periodontitis. Recent evidence also suggests an association between obesity and increased risk for periodontitis. Our previous research showed incremental elevation of resistin with periodontal disease activity and a reduced level of resistin, after periodontal therapy. Thus resistin would be one of the molecular links connecting obesity, periodontitis, and diabetes and may serve as a marker that links periodontal disease with other systemic diseases. A Medline/PubMed search was carried out for keywords "Diabetes Mellitus," "Periodontitis," and "Resistin," and all relevant research papers from 1990 in English were shortlisted and finalized based on their importance. This review provides an insight into the biological action of resistin and its possible role in periodontitis influenced diabetes mellitus and diabetes induced periodontitis.
authors.affiliation: Department of Periodontics, A.M.E's Dental College and Hospital, Raichur, Karnataka 584103, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Devanoorkar
authors.affiliation: Department of Periodontics and Oral Implantology, Dr. DY Patil Dental College and Hospital, Dr. DY Patil Vidyapeeth, Pune 411018, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Kathariya
authors.affiliation: Department of Periodontics, A.M.E's Dental College and Hospital, Raichur, Karnataka 584103, India.
authors.forename: Nagappa
authors.initials: N
authors.lastname: Guttiganur
authors.affiliation: Department of Periodontics and Oral Implantology, Dr. DY Patil Dental College and Hospital, Dr. DY Patil Vidyapeeth, Pune 411018, India.
authors.forename: D
authors.initials: D
authors.lastname: Gopalakrishnan
authors.affiliation: Department of Prosthodontics, Dr. DY Patil Dental School, Knowledge City, Lohegaon, Pune 412105, India.
authors.forename: Paulami
authors.initials: P
authors.lastname: Bagchi
mesh_terms: D054392:Adipokines / Q000502:physiology; D000818:Animals; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000209:etiology / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D009765:Obesity / Q000097:blood / Q000276:immunology; D010518:Periodontitis / Q000097:blood* / Q000209:etiology / Q000276:immunology; D052243:Resistin / Q000502:physiology*; D012307:Risk Factors
chemical_list: D054392:Adipokines; D015415:Biomarkers; D018836:Inflammation Mediators; C499624:RETN protein, human; D052243:Resistin