title: Cyclic lipodepsipeptides verlamelin A and B, isolated from entomopathogenic fungus Lecanicillium sp.
abstract: Verlamelin and its new derivative (verlamelin B) were isolated from fermentation broth of entomopathogenic fungus Lecanicillium sp. HF627. As the structural elucidation of verlamelin so far was only preliminary, we studied and determined the absolute structure of these two compounds to be cyclo(5S-hydroxytetradecanoic acid-D-alloThr/Ser-D-Ala-L-Pro-L-Gln-D-Tyr-L-Val). This is the first study that precisely analyzed the structure of verlamelin.
authors.affiliation: International Center for Biotechnology, Osaka University, Osaka, Japan.
authors.forename: Kei-Ichi
authors.initials: K
authors.lastname: Ishidoh
authors.affiliation: International Center for Biotechnology, Osaka University, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kinoshita
authors.affiliation: Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
authors.affiliation: National Institute of Fruit Tree Science, Ibaraki, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Ihara
authors.affiliation: 1] International Center for Biotechnology, Osaka University, Osaka, Japan [2] Mahidol University-Osaka University Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand.
authors.forename: Takuya
authors.initials: T
authors.lastname: Nihira
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D005285:Fermentation; D006999:Hypocreales / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D010456:Peptides, Cyclic; C051491:verlamelin