title: A clinical perspective on mucoadhesive buccal drug delivery systems.
abstract: Mucoadhesion can be defined as a state in which two components, of which one is of biological origin, are held together for extended periods of time by the help of interfacial forces. Among the various transmucosal routes, buccal mucosa has excellent accessibility and relatively immobile mucosa, hence suitable for administration of retentive dosage form. The objective of this paper is to review the works done so far in the field of mucoadhesive buccal drug delivery systems (MBDDS), with a clinical perspective. Starting with a brief introduction of the mucoadhesive drug delivery systems, oral mucosa, and the theories of mucoadhesion, this article then proceeds to cover the works done so far in the field of MBDDS, categorizing them on the basis of ailments they are meant to cure. Additionally, we focus on the various patents, recent advancements, and challenges as well as the future prospects for mucoadhesive buccal drug delivery systems.
authors.affiliation: Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan 302025, India;
authors.forename: Ritu M
authors.initials: RM
authors.lastname: Gilhotra
authors.affiliation: Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan 302025, India;
authors.forename: Mohd
authors.initials: M
authors.lastname: Ikram
authors.affiliation: Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan 302025, India;
authors.forename: Sunny
authors.initials: S
authors.lastname: Srivastava
authors.affiliation: Faculty of Pharmacy, Maharshi Dayanand University, Rohtak, Haryana 124001, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Gilhotra
keywords: buccal mucosa; clinical perspective; mucoadhesion; patents; transmucosal route