title: High-frequency intra-operative ultrasound-guided surgery of superficial intra-cerebral lesions via a single-burr-hole approach.
abstract: The study described here examined the feasibility of using high-frequency intra-operative ultrasound (hfioUS) guidance to resect superficial intra-cerebral lesions through a single burr hole. A cohort of 23 consecutive patients with a total of 24 intra-cerebral lesions (9 intra-cerebral metastases, 8 gliomas, 4 infections, 2 lymphomas and 1 cavernoma) were studied. All lesions could be localized and successfully resected, biopsied or aspirated, and histopathological diagnoses were obtained in all cases. The mean operating time was 59.6 ± 23.9 min. The mean cross-sectional lesion size was 6.4 ± 7.6 cm(2), and the mean cortex surface-to-lesion distance was 0.6 ± 0.8 cm. Our results illustrate the feasibility of identifying and resecting superficial intra-cerebral lesions under hfioUS guidance via a single-burr-hole approach. We were able to achieve short resection times with no post-operative complications in all patients, favorable conditions under which to start adjuvant therapy when indicated.
authors.affiliation: Department of Neurosurgery, University Hospital of Zurich, Zurich, Switzerland. Electronic address: JanKarl.Burkhardt@gmail.com.
authors.forename: Jan-Karl
authors.initials: JK
authors.lastname: Burkhardt
authors.affiliation: Department of Neurosurgery, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Carlo
authors.initials: C
authors.lastname: Serra
authors.affiliation: Department of Neurosurgery, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Marian C
authors.initials: MC
authors.lastname: Neidert
authors.affiliation: Department of Neurosurgery, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Christoph M
authors.initials: CM
authors.lastname: Woernle
authors.affiliation: Department of Neurosurgery, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Jorn
authors.initials: J
authors.lastname: Fierstra
authors.affiliation: Department of Neurosurgery, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Luca
authors.initials: L
authors.lastname: Regli
authors.affiliation: Department of Neurosurgery, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Oliver
authors.initials: O
authors.lastname: Bozinov
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012886:Skull / Q000000981:diagnostic imaging* / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome; D014207:Trephining / Q000379:methods*; D014463:Ultrasonography / Q000379:methods
keywords: High-frequency intra-operative ultrasound; Navigated burr hole approach; Superficial intra-cerebral lesions