title: Carboxypeptidase E (NF-α1): a new trophic factor in neuroprotection.
abstract: Carboxypeptidase E (CPE) is a prohormone-processing enzyme and sorting receptor that functions intracellularly. However, recent studies have demonstrated that CPE acts as a trophic factor extracellularly to up-regulate the expression of a pro-survival gene. This mini-review summarizes the roles of CPE in neuroprotection and the implications for neurodegenerative diseases.
authors.affiliation: Section on Cellular Neurobiology, Program on Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cheng
authors.forename: Niamh X
authors.initials: NX
authors.lastname: Cawley
authors.forename: Y Peng
authors.initials: YP
authors.lastname: Loh
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology*; D043423:Carboxypeptidase H / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D019636:Neurodegenerative Diseases / Q000201:enzymology*; D015398:Signal Transduction
chemical_list: D043423:Carboxypeptidase H