title: A study of neuroprotective and antioxidant activities of heteropolysaccharides from six Sargassum species.
abstract: Heteropolysaccharides were extracted from Sargassum integerrimum (S.I), Sargassum maclurei (S.M), Sargassum naozhouense (S.N), Spiraea thunbergii (S.T), Sargassum hemiphyllum (S.H) and Sargassum fusiforme (S.F), and their neuroprotective effects and antioxidant activities were investigated. It showed that S.I, S.N, S.T and S.F exhibited neuroprotective activities, whereas S.H and S.M did not. For this reason, they were separated by anion-exchange chromatography. It was apparent that the fraction 2 represented the principal difference between the active and non-active compounds. However, it did not correlate with neuroprotective effect. In addition, the results on antioxidant activities showed that the hydroxyl-radical scavenging effect contribute to the neuroprotective effect of S.T and S.N, and the DPPH-radical scavenging effect and reducing power contribute to S.T, S.F and S.I. However, the superoxide-radical scavenging effect did not correlate with neuroprotective activity. The conclusion was that the neuroprotective activity of the family of compounds investigated depended on a variety of factors.
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China; Nantong Branch, Institute of Oceanology, Chinese Academy of Sciences, Nantong 226006, Jiangsu, PR China. Electronic address: jinweihua09@mails.ucas.ac.cn.
authors.forename: Weihua
authors.initials: W
authors.lastname: Jin
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China; Nantong Branch, Institute of Oceanology, Chinese Academy of Sciences, Nantong 226006, Jiangsu, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China.
authors.forename: Jianting
authors.initials: J
authors.lastname: Yao
authors.affiliation: Fisheries College, Guangdong Ocean University, Zhanjiang 524025, PR China.
authors.forename: Enyi
authors.initials: E
authors.lastname: Xie
authors.affiliation: Fisheries College, Guangdong Ocean University, Zhanjiang 524025, PR China.
authors.forename: Dongchao
authors.initials: D
authors.lastname: Liu
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China.
authors.forename: Delin
authors.initials: D
authors.lastname: Duan
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China. Electronic address: qbzhang@ms.qdio.ac.cn.
authors.forename: Quanbin
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry; D006801:Humans; D017665:Hydroxyl Radical / Q000737:chemistry; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000737:chemistry; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D011134:Polysaccharides / Q000008:administration & dosage*; D044647:Sargassum / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D018696:Neuroprotective Agents; D010936:Plant Extracts; D011134:Polysaccharides; D013481:Superoxides; D017665:Hydroxyl Radical
keywords: Antioxidant activity; Neuroprotective activity; Sargassum