title: Ovarian aging-like phenotype in the hyperandrogenism-induced murine model of polycystic ovary.
abstract: There are prominently similar symptoms, effectors, and commonalities in the majority of characteristics between ovarian aging and polycystic ovarian syndrome (PCOS). Despite the approved role of oxidative stress in the pathogenesis of PCOS and aging, to our knowledge, the link between the PCO(S) and aging has not been investigated yet. In this study we investigated the possible exhibition of ovarian aging phenotype in murine model of PCO induced by daily oral administration of letrozole (1 mg/kg body weight) for 21 consecutive days in the female Wistar rats. Hyperandrogenization showed irregular cycles and histopathological characteristics of PCO which was associated with a significant increase in lipid peroxidation (LPO) and reactive oxygen species (ROS) and decrease in total antioxidant capacity (TAC) in serum and ovary. Moreover, serum testosterone, insulin and tumor necrosis factor-alpha (TNF-α) levels, and ovarian matrix metalloproteinase-2 (MMP-2) were increased in PCO rats compared with healthy controls, while estradiol and progesterone diminished. Almost all of these findings are interestingly found to be common with the characteristics identified with (ovarian) aging showing that hyperandrogenism-induced PCO in rat is associated with ovarian aging-like phenotypes. To our knowledge, this is the first report that provides evidence regarding the phenomenon of aging in PCO.
authors.affiliation: Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran ; Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
authors.forename: Mohammad Amin
authors.initials: MA
authors.lastname: Rezvanfar
authors.affiliation: Centre de Recherche en Biologie de la Reproduction, Université Laval, Québec City, QC, Canada G1V 0A6.
authors.forename: Habib A
authors.initials: HA
authors.lastname: Shojaei Saadi
authors.affiliation: Faculty of Medicine, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
authors.forename: Maziar
authors.initials: M
authors.lastname: Gooshe
authors.affiliation: Pharmacology and Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Alborz 141554364, Iran ; International Campus, Tehran University of Medical Sciences (ICTUMS), Tehran 1417653861, Iran.
authors.forename: Amir Hosein
authors.initials: AH
authors.lastname: Abdolghaffari
authors.affiliation: Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Baeeri
authors.affiliation: Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran ; Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
mesh_terms: D000375:Aging / Q000473:pathology; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001835:Body Weight; D004195:Disease Models, Animal; D030762:Estrous Cycle; D005260:Female; D017588:Hyperandrogenism / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D007249:Inflammation / Q000473:pathology; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D009929:Organ Size; D006080:Ovarian Follicle / Q000473:pathology / Q000503:physiopathology; D010053:Ovary / Q000201:enzymology / Q000473:pathology*; D018384:Oxidative Stress; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013256:Steroids / Q000378:metabolism
chemical_list: D015415:Biomarkers; D013256:Steroids; D020778:Matrix Metalloproteinase 2