title: Neutrophil-lymphocyte ratio and carotid-intima media thickness in patients with Behçet disease without cardiovascular involvement.
abstract: Behçet disease (BD) is associated with endothelial dysfunction and chronic inflammation. The neutrophil-lymphocyte (N/L) ratio and carotid intima-media thickness (cIMT) are markers of inflammation and vascular risk, respectively. We assessed the relationship between cIMT values and N/L ratio in BD (65 patients and 62 control participants). There were statistically significant differences in N/L ratios and cIMT values between the patients with BD and control group (P < .001). There were moderate positive correlations between cIMT value, C-reactive protein, and N/L ratio in patients with BD. Receiver-operating characteristic curve analysis suggested that the optimum N/L ratio cutoff point for patients with BD was 1.29, with a sensitivity, specificity, negative predictive value, and positive predictive value of 97, 77, 96, and 75%, respectively (area under curve: 0.691, 95% confidence interval = 0.600-0.782, P < .001). The N/L ratio may be a useful index of BD activity.
authors.affiliation: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozturk
authors.affiliation: Department of Cardiology, Eskişehir Military Hospital, Eskişehir, Turkey drsevketb@gmail.com.
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.affiliation: Department of Dermatology, Eskisehir State Hospital, Ankara, Turkey.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Balta
authors.affiliation: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Demirkol
authors.affiliation: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors.forename: Turgay
authors.initials: T
authors.lastname: Celik
authors.affiliation: Department of Epidemiology, Gulhane Medical Academy, Ankara, Turkey.
authors.forename: Turker
authors.initials: T
authors.lastname: Turker
authors.affiliation: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors.forename: Atila
authors.initials: A
authors.lastname: Iyisoy
authors.affiliation: Department of Dermatology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Meral
authors.initials: M
authors.lastname: Eksioglu
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001528:Behcet Syndrome / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein
keywords: Behçet disease; carotid intima–media thickness; disease activity; neutrophil–lymphocyte ratio