title: Healthy Eating Index is associated with certain markers of inflammation and insulin resistance but not with lipid profile in individuals at cardiometabolic risk.
abstract: Eating habits may influence inflammatory status and insulin resistance, both involved in the genesis of cardiometabolic diseases; an index of overall diet quality may be useful to identify risk for these diseases. We investigated whether the Healthy Eating Index (HEI-2005), adapted to Brazilian habits (B-HEI), was associated with markers of inflammation, insulin resistance and lipid profile in individuals at cardiometabolic risk. Two hundred and four prediabetic individuals (64.7% women) were enrolled in this cross-sectional study. Anthropometric measurements, 24-h dietary recalls used to calculate the B-HEI, and blood samples were collected. ANOVA was used for comparisons of clinical variables across the B-HEI tertiles and multiple linear regressions employed to test associations between clinical variables and B-HEI total score. Significant trends to decrease mean values of body mass index (BMI) (p = 0.03) and C-reactive protein concentrations (p = 0.02) across the tertiles of B-HEI, but not other biomarkers, were observed. Waist circumference, HOMA-IR and C-reactive protein were inversely associated with the B-HEI (p < 0.05), after adjusting for age, sex, BMI, and physical activity level. Also, a direct association of adiponectin concentrations with B-HEI was detected after adjustments (p = 0.001). Data from this study indicate that the B-HEI may be useful to identify the body adiposity-induced pro-inflammatory status and insulin resistance in individuals at cardiometabolic risk.
authors.affiliation: School of Public Health, Department of Nutrition, University of São Paulo, Av. Dr. Arnaldo, 715 - São Paulo, SP, Brasil - CEP 01246-904.
authors.forename: Milena
authors.initials: M
authors.lastname: Monfort-Pires
authors.forename: Luciana Dias
authors.initials: LD
authors.lastname: Folchetti
authors.forename: Agatha Nogueira
authors.initials: AN
authors.lastname: Previdelli
authors.forename: Antonela
authors.initials: A
authors.lastname: Siqueira-Catania
authors.forename: Camila Risso
authors.initials: CR
authors.lastname: de Barros
authors.forename: Sandra Roberta Gouvea
authors.initials: SR
authors.lastname: Ferreira
mesh_terms: D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein; D003430:Cross-Sectional Studies; D005247:Feeding Behavior; D005260:Female; D015438:Health Behavior; D006331:Heart Diseases / Q000453:epidemiology / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008297:Male; D008659:Metabolic Diseases / Q000453:epidemiology / Q000378:metabolism*; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein