title: GSTM1-null and GSTT1-null genotypes are associated with essential arterial hypertension in patients with type 2 diabetes.
abstract: OBJECTIVE
  To evaluate whether the genetic polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1), Ile105Val of the GSTP1 (rs947894), and the Val16Ala polymorphism of the MnSOD (rs4880) are associated with essential arterial hypertension (EAH) in Caucasians with type 2 diabetes.
  
  
  METHODS
  1015 Slovenian subjects (Caucasians) with type 2 diabetes with/without EAH were enrolled in the cross-sectional study. Genotypes were determined by multiplex PCR amplification and PCR-restriction fragment length polymorphism method.
  
  
  RESULTS
  In the cross-sectional study, GSTM1-null genotype and GSTT1-null genotype were associated with EAH in subjects with type 2 diabetes (59.0% vs. 50.3%, p=0.007; 28.5% vs. 20.7%, p=0.008; consequently).
  
  
  CONCLUSIONS
  After adjustment for age, body mass index, and hsCRP level, GSTM1-null and GSTT1-null genotypes were found to be independent risk factors for the development of EAH in Slovenian patients with type 2 diabetes.
authors.affiliation: Institute of Histology and Embryology, Medical Faculty Ljubljana, University Ljubljana, Korytkova 2, SI-1000 Ljubljana, Slovenia. Electronic address: daniel.petrovic@mf.uni-lj.si.
authors.forename: Daniel
authors.initials: D
authors.lastname: Petrovič
authors.affiliation: Clinical Institute of Medical Genetics, University Clinical Centre Ljubljana, Zaloška 7, SI-1000 Ljubljana, Slovenia.
authors.forename: Borut
authors.initials: B
authors.lastname: Peterlin
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000503:physiopathology*; D000075222:Essential Hypertension; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D044465:White People / Q000235:genetics
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1
keywords: Diabetes mellitus type 2; Essential arterial hypertension; GSTM1; GSTP1; GSTT1; Gene polymorphism; Genes; Glutathione S-transferases; MnSOD; Oxidative stress