title: Pulmonary function after lobectomy versus segmentectomy in patients with stage I non-small cell lung cancer.
abstract: BACKGROUND
  Several reports have shown that segmentectomy is superior to lobectomy for preservation of postoperative pulmonary function. The purpose of this study was to characterize the relationship between pulmonary function and the volume of the resected lung in patients undergoing segmentectomy or lobectomy.
  
  
  METHODS
  Patients undergoing open lobectomy (n = 126) and open segmentectomy (n = 52) for stage I non-small cell lung cancer were analyzed retrospectively. Pulmonary function testing, including vital capacity (VC) and forced expiratory volume in 1 second (FEV1), was performed preoperatively and at 1 and 6 months postoperatively.
  
  
  RESULTS
  The postoperative reduction of VC and FEV1, as indicated by the postoperative value/preoperative value, at 6 months after surgery was significantly less in the segmentectomy group than in the lobectomy group. However, the standardized functional loss ratio, as expressed by [(measured postoperative value)-(predicted postoperative value)] / (predicted postoperative value) × 100 (%), at 1 month after surgery was significantly lower in the segmentectomy group than in the lobectomy group. No significant difference in the standardized functional loss ratio was seen at 6 months postoperatively.
  
  
  CONCLUSIONS
  Pulmonary function at 6 months after surgery is better after segmental resection than after lobectomy. However, the absolute value of pulmonary function did not reach the predicted-postoperative value at 1 month after surgery. Thus, when segmentectomy is performed, clinicians should be aware that early postoperative pulmonary function may be significantly less than the expected value.
authors.affiliation: Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan, hsaito@doc.med.akita-u.ac.jp.
authors.forename: Hajime
authors.initials: H
authors.lastname: Saito
authors.forename: Taku
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Manabu
authors.initials: M
authors.lastname: Ito
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Imai
authors.forename: Takashi
authors.initials: T
authors.lastname: Ono
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Minamiya
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008175:Lung Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000379:methods*; D011184:Postoperative Period; D012129:Respiratory Function Tests / Q000379:methods; D012189:Retrospective Studies; D014797:Vital Capacity / Q000502:physiology