title: Impact of endovascular therapy on oxidative stress in patients with peripheral artery disease.
abstract: BACKGROUND
  Atherosclerosis is believed to be caused by oxidative stress. Endovascular therapy (EVT) is effective for claudication of patients with peripheral artery disease (PAD). However, its effect on oxidative stress in PAD patients is unknown. Here, the impact of EVT on oxidative stress in PAD patients is investigated.
  
  
  RESULTS
  Twenty-five PAD patients (Rutherford stage II or III) who underwent EVT were enrolled. The levels of diacron-reactive oxygen metabolite (d-ROM; an oxidative stress marker), ankle-brachial index (ABI), and maximum walking distance at baseline and at 3 months after EVT were measured. As compared with baseline values, the maximum walking distance and ABI improved significantly after EVT (109.9±104.2 vs. 313.7±271.8m, P<0.0001; 0.61±0.15 vs. 0.91±0.13m, P<0.0001, respectively). The improved exercise capacity and arterial flow induced a significant decrease in d-ROM levels (from 472.8±64.8 to 390.2±46.7U.CARR; P<0.0001). The decrease in d-ROM levels after EVT was more prominent in PAD patients with a high baseline d-ROM level. The increased ABI (r=0.524, P=0.0007) and maximum walking distance (r=-0.416, P=0.039) after EVT were significantly correlated with the decreased d-ROM levels.
  
  
  CONCLUSIONS
  The improved exercise capacity and peripheral blood flow induced by EVT decreases oxidative stress in PAD patients.
authors.affiliation: Department of Cardiovascular Medicine, Shinshu University School of Medicine.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ebisawa
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kashima
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Miyashita
authors.forename: Saeko
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Abe
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Saigusa
authors.forename: Takashi
authors.initials: T
authors.lastname: Miura
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Motoki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Izawa
authors.forename: Uichi
authors.initials: U
authors.lastname: Ikeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D001783:Blood Flow Velocity; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D058729:Peripheral Arterial Disease / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D017382:Reactive Oxygen Species / Q000097:blood*
chemical_list: D017382:Reactive Oxygen Species