title: Comparative study of cardio-ankle vascular index between Chinese and Japanese healthy subjects.
abstract: OBJECTIVE
  Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. However, there was little research about the CAVI value between different countries. The aim of the present study was to compare CAVI between Chinese and Japanese subjects and to assess related factors.
  
  
  METHODS
  2519 healthy persons [1245 Chinese (M/F, 524/721) and 1274 Japanese (M/F, 534/740)] from the Department of Physical Examination were enrolled into our study. CAVI was recorded using a VaseraVS-1000 vascular screening system.
  
  
  RESULTS
  CAVI was increasing with aging in all subjects. CAVI was significantly lower in Chinese compared with Japanese both in male and female. There was difference in lipid metabolism between these two groups. Multivariate analysis showed that age, systolic blood pressure (SBP), fasting plasma glucose (FPG), plasma creatinine (Cr) were significant independent associating factors of CAVI in Chinese persons (β = 0.548, p < 0.001; β = 0.129, p = 0.001; β = 0.105, p = 0.006; and β = 0.100, p = 0.012, respectively), whereas age, SBP, high-density lipoprotein cholesterol (HDL-C), Cr, body mass index (BMI), FPG were significant independent associating factors of CAVI in Japanese subjects (β = 0.669, p < 0.001; β = 0.198, p < 0.001; β = -0.079, p < 0.001; β = 0.090, p < 0.001; β = -0.124, p < 0.001; β = 0.055, p=0.009; respectively).
  
  
  CONCLUSIONS
  CAVI was increasing with aging in both Chinese and Japanese subjects. CAVI was significantly lower in Chinese than in Japanese subjects. Age, SBP, FPG and creatinine were independently associated with CAVI in both Chinese and Japanese subjects.
authors.affiliation: Department of Vascular Medicine, Peking University Shougang Hospital , Beijing , P.R. China .
authors.forename: Hongyu
authors.initials: H
authors.lastname: Wang
authors.forename: Kohji
authors.initials: K
authors.lastname: Shirai
authors.forename: Jinbo
authors.initials: J
authors.lastname: Liu
authors.forename: Na
authors.initials: N
authors.lastname: Lu
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhao
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Yu
authors.forename: Xiaobao
authors.initials: X
authors.lastname: Fu
authors.forename: Hongyan
authors.initials: H
authors.lastname: Shi
authors.forename: Lihong
authors.initials: L
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D000842:Ankle / Q000098:blood supply; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002681:China; D003404:Creatinine / Q000097:blood; D005260:Female; D064368:Healthy Volunteers; D006321:Heart / Q000502:physiology; D006801:Humans; D007564:Japan; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012016:Reference Values; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D003404:Creatinine
keywords: Arterial stiffness; Chinese; Japanese; arteriosclerosis; cardio-ankle vascular index