title: The transcription factor CUTL1 is associated with proliferation and prognosis in malignant melanoma.
abstract: The transcription factor CUTL1 (CCAAT displacement protein 1) has been reported to participate in the proliferation of diverse types of cancer. In the present study, we investigated the potential involvement of CUTL1 in the proliferation of malignant melanoma. We found that CUTL1 expression was upregulated in malignant melanoma tissues and cell lines, and CUTL1 expression was selected as a prognostic predictor for malignant melanoma patients by both univariate and multivariate analysis. Knockdown of CUTL1 by short hairpin RNA significantly reduced the colony-forming ability of malignant melanoma cells in vitro and reduced tumor growth in vivo, whereas forced overexpression of CUTL1 produced the opposite results. Consistently, cell cycle progression was impaired upon downregulation of CUTL1 and enhanced when CUTL1 was upregulated. Additional experiments suggested that CUTL1 may regulate the proliferation of malignant melanoma by modulating the expression of cell cycle-related proteins.
authors.affiliation: aInstitute of Plastic Surgery of the Chinese PLA bDepartment of Dermatology, Xijing Hospital cState Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Fan
authors.forename: Honghong
authors.initials: H
authors.lastname: Wang
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Zhou
authors.forename: Shiping
authors.initials: S
authors.lastname: Wang
authors.forename: Xiangwei
authors.initials: X
authors.lastname: Zhang
authors.forename: Tong
authors.initials: T
authors.lastname: Li
authors.forename: Yongzhan
authors.initials: Y
authors.lastname: Nie
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D000818:Animals; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D018797:Cell Cycle Proteins / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D005260:Female; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D015999:Multivariate Analysis; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D034622:RNA Interference; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D013997:Time Factors; D014157:Transcription Factors; D014162:Transfection; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: C080632:CUX1 protein, human; D018797:Cell Cycle Proteins; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; D014157:Transcription Factors