title: Ehlers-Danlos Syndrome and Postural Tachycardia Syndrome: a relationship study.
abstract: OBJECTIVE
  This study examines a possible relationship between Ehlers-Danlos Syndrome (EDS) and Postural Tachycardia Syndrome (POTS).
  
  
  METHODS
  We retrospectively reviewed 109 medical records of patients suffering from autonomic dysfunction exhibiting at least one POTS symptom from one urban clinic for EDS and POTS diagnoses between 2006 and 2013. The presence of EDS within the POTS and non-POTS populations was calculated and compared to that of the general population.
  
  
  RESULTS
  The review revealed 39 (36F:3M) patients with POTS (mean ± SD age, 32.5 ± 11.8 years) with 7 cases of EDS yielding a prevalence of 18% (95% exact CI: 8%, 34%), a statistically significant difference from the suggested prevalence of EDS in the general population of 0.02% (p<0.0001). 70 patients (53F:17M) without POTS (mean ± SD age, 51.1 ± 14.7 years) contained 3 cases of EDS, yielding a prevalence of 4% (95% exact CI: 1%, 12%), a statistically significant difference from the general population (p<0.0001). The prevalence of EDS was significantly higher in the POTS group compared to the non-POTS group (p=0.0329). The odds ratio comparing the odds of EDS for POTS versus non-POTS patients is 4.9 (95% CI: 1.2, 20.1).
  
  
  CONCLUSIONS
  The presence of EDS may be significantly higher in patients with POTS than that of the general population and in autonomic patients without POTS. We suspect an additional underlying mechanism of POTS caused by EDS.
authors.affiliation: Boston University School of Medicine, 72 East Concord St, A-302, Boston, MA 02118, USA. Electronic address: dwallman@bu.edu.
authors.forename: Daniel
authors.initials: D
authors.lastname: Wallman
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston University Medical Campus, 801 Massachusetts Avenue, 3rd Floor, Boston, MA 02118, USA. Electronic address: janicew@bu.edu.
authors.forename: Janice
authors.initials: J
authors.lastname: Weinberg
authors.affiliation: Boston University School of Medicine/BMC, 725 Albany Street, 7th Floor, Boston, MA 02118, USA. Electronic address: Anna.hohler@bmc.org.
authors.forename: Anna Depold
authors.initials: AD
authors.lastname: Hohler
mesh_terms: D000328:Adult; D004185:Disability Evaluation; D004535:Ehlers-Danlos Syndrome / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054972:Postural Orthostatic Tachycardia Syndrome / Q000453:epidemiology*; D012189:Retrospective Studies
keywords: Autonomic dysfunction; Ehlers–Danlos Syndrome; Postural Tachycardia Syndrome