title: The association between therapeutic outcomes and VEGF G-1154A and C-936T gene polymorphisms in patients with glomerulonephritis.
abstract: BACKGROUND
  In this present study, we aimed to investigate the association between therapeutic outcomes and vascular endothelial growth factor (VEGF) G-1154A and C-936T gene polymorphisms in patients with glomerulonephritis.
  
  
  METHODS
  Thirty-eight patients with glomerulonephritis diagnosed by renal biopsy were included to the study. All patients had proteinuria at least 1 gram (g)/day in urine analysis. At the end of a yearly therapy, patients with proteinuria less than 0.5 g/day were accepted as in complete remission and they were termed as group 1. The patients with proteinuria over 0.5 g/day were accepted as in no remission and they were termed as group 2.
  
  
  RESULTS
  The mean age of patients in group 1 and group 2 was 35.88 ± 13.80 years and 37.30 ± 13.89 years, respectively. There were nine (50%) male and nine (50%) female patients in group 1. In group 2, seven (35%) male and 13 (65%) female patients were present. Although VEGF G-1154A (GG) gene polymorphism was found in 55% of group 2 patients, and 22.2% of group 1 patients, but the differences did not reach statistical significance. There were no statistical differences between groups in terms of other gene polymorphisms. Namely, we obtained no statistical differences between therapeutic outcomes and gene polymorphisms.
  
  
  CONCLUSIONS
  There is a significant difference between groups in terms of VEGF G-1154A (GG) gene polymorphism, but the minority of the patient population has led to not to reach statistical significance. So, this gene polymorphism has to be investigated in larger studies.
authors.affiliation: Department of Hematology, Faculty of Medicine, Cumhuriyet University , Sivas , Turkey .
authors.forename: Hatice
authors.initials: H
authors.lastname: Terzi
authors.forename: Mansur
authors.initials: M
authors.lastname: Kayatas
authors.forename: Serdal
authors.initials: S
authors.lastname: Korkmaz
authors.forename: Gürsel
authors.initials: G
authors.lastname: Yildiz
authors.forename: Ferhan
authors.initials: F
authors.lastname: Candan
mesh_terms: D000328:Adult; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D055815:Young Adult
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: Gene polymorphism; glomerulonephritis; proteinuria; therapeutic outcomes; vascular endothelial growth factor