title: The molecular and systems biology of memory.
abstract: Learning and memory are two of the most magical capabilities of our mind. Learning is the biological process of acquiring new knowledge about the world, and memory is the process of retaining and reconstructing that knowledge over time. Most of our knowledge of the world and most of our skills are not innate but learned. Thus, we are who we are in large part because of what we have learned and what we remember and forget. In this Review, we examine the molecular, cellular, and circuit mechanisms that underlie how memories are made, stored, retrieved, and lost.
authors.affiliation: Kavli Institute for Brain Science, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA; Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA; Departments of Neuroscience, Biochemistry and Molecular Biophysics, and Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA. Electronic address: erk5@columbia.edu.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Kandel
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Yadin
authors.initials: Y
authors.lastname: Dudai
authors.affiliation: Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Mayford
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D007858:Learning; D008568:Memory; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D012890:Sleep; D013569:Synapses / Q000378:metabolism; D049490:Systems Biology