title: Nucleoside derivatives from the marine-derived fungus Aspergillus versicolor.
abstract: Four nucleoside derivatives (1-4) were isolated from the fungus Aspergillus versicolor derived from the gorgonian Dichotella gemmacea collected in the South China Sea. Their structures were elucidated by comprehensive spectroscopic method of NMR and MS analysis. All isolated metabolites were evaluated for their cytotoxicity, antibacterial activity and lethality towards brine shrimp Artemia salina. Compounds 1/2 exhibited selective antibacterial activity against Staphylococcus epidermidis with an MIC value of 12.5 μM. It should be noted that 1 and 2, whose structures were listed in SciFinder Scholar, had no associated reference. This is the first report about their isolation, structure elucidation and biological activities.
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , 5 Yushan Road, Qingdao 266003 , People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Xiu-Mei
authors.initials: XM
authors.lastname: Fu
authors.forename: Chui-Jian
authors.initials: CJ
authors.lastname: Kong
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D001156:Artemia / Q000187:drug effects; D001230:Aspergillus / Q000737:chemistry*; D002681:China; D005658:Fungi; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009705:Nucleosides / Q000737:chemistry / Q000302:isolation & purification*; D009792:Oceans and Seas; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D009705:Nucleosides
keywords: Aspergillus versicolor; antibacterial activity; marine-derived fungus; nucleoside derivative; transesterification