title: Surgical impact on serum anti-Müllerian hormone in women with benign ovarian cyst: A prospective study.
abstract: OBJECTIVE
  The aim of this study was to evaluate the surgical impact of benign ovarian mass on ovarian reserve as measured by serum follicle stimulating hormone (FSH), estradiol (E2) and anti-Müllerian hormone (AMH) levels, antral follicle count (AFC) and ovarian volumes. In addition, the differences in ovarian reserve impairment between endometrioma cystectomy and non-endometrioma cystectomy were investigated.
  
  
  METHODS
  In this prospective study, 22 patients of reproductive age (range, 18.35 years) with benign ovarian masses were enrolled to undergo laparoscopic cystectomy. Of whom 12 had endometriomas and 10 had non-endometriomas. On early follicular phase (day 3) of the cycle preceding the operation and three months after the laparoscopic cystectomy, serum levels of FSH, E2 and AMH, AFC and ovarian volumes were measured in all patients. Data were analyzed with Mann-Whitney U-test and Wilcoxon rank test using SPSS ver. 12.0 for statistic analysis.
  
  
  RESULTS
  Median level of serum AMH was significantly decreased from 5.48 ng/mL (interquartile range [IQR], 2.80-7.47) before cystectomy to 2.56 ng/mL (IQR, 1.74-4.32) 3 months postoperation (P<0.05). On the other hand, no significant differences in FSH, E2, AFC and ovarian volumes were found between the preoperative and three months postoperative levels. In a subgroup analysis of the pathologic type of the ovarian cyst, postoperative serum AMH levels were significantly decreased in the endometrioma group, but not in the non-endometrioma group.
  
  
  CONCLUSIONS
  Serum AMH levels were significantly decreased after laparoscopic cystectomy without any changes of other ovarian reserve tests.
authors.affiliation: Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Won Kyu
authors.initials: WK
authors.lastname: Jang
authors.affiliation: Department of Obstetrics and Gynecology, Hyosung Hospital, Daegu, Korea.
authors.forename: Su Yeon
authors.initials: SY
authors.lastname: Lim
authors.affiliation: Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Joon Cheol
authors.initials: JC
authors.lastname: Park
authors.affiliation: Department of Laboratory Medicine, Seoul Clinical Laboratories, Seoul, Korea.
authors.forename: Kyung Ryul
authors.initials: KR
authors.lastname: Lee
authors.affiliation: Department of Laboratory Medicine, Seoul Clinical Laboratories, Seoul, Korea.
authors.forename: Anna
authors.initials: A
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Jeong Ho
authors.initials: JH
authors.lastname: Rhee
keywords: Anti-Müllerian hormone; Benign ovarian mass; Endometrioma; Laparoscopic cystectomy