title: Bisphophonates related osteonecrosis of the jaw.
abstract: OBJECTIVE
  With sporadic reporting of BPs related osteonecrosis of jaw and in absence of definitive guidelines regarding the management of such patients, the dentists and the oral and maxillofacial surgeons need to be updated about this issue. The objective of this article was to produce an updated bibliographic review of BPs related ONJ. This paper reviews the literature regarding the same for better understanding of the problem and its management.
  
  
  BACKGROUND
  Bisphosphonates (BPs) are potent inhibitors of bone resorption and are widely used in the treatment of osteoporosis and other diseases that cause bone mass loss, such as Paget's disease, bone metastases, and multiple myeloma, to prevent pathological fractures. With increasing use, evidence is emerging that patients taking BP drugs are at risk of developing osteonecrosis of the jaws (ONJs), sometimes occurring spontaneously, but more commonly following dental extractions or oral bone surgery.
  
  
  METHODS
  A bibliographic search was carried out using PubMed, Medline, and search engines ending in April, 2013. The search terms used were: Oral BPs, dental implants, and osteonecrosis.
  
  
  CONCLUSIONS
  On the basis of available literature, the management of patients on bisphosphonates requiring dental treatment is classified according to the duration of BPs treatment, method of administration of BPs etc. Dental treatments when planned carefully in such patients have a fair to good prognosis.
authors.affiliation: Department of Prosthodontics, Babu Banarasi Das College of Dental Sciences, Lucknow, India.
authors.forename: Swati
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Oral and Maxillofacial Surgery, Babu Banarasi Das College of Dental Sciences, Lucknow, India.
authors.forename: Hemant
authors.initials: H
authors.lastname: Gupta
authors.affiliation: Department of Prosthodontics, Chandra Dental College and Research Centre, Lucknow, India.
authors.forename: Devendra
authors.initials: D
authors.lastname: Mandhyan
authors.affiliation: Department of Conservative Dentistry, Saraswati Dental College, Lucknow, Uttar Pradesh, India.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Srivastava
keywords: Bisphosphonate; implants; osteonecrosis of jaw