title: Advances in metabolic engineering of yeast Saccharomyces cerevisiae for production of chemicals.
abstract: Yeast Saccharomyces cerevisiae is an important industrial host for production of enzymes, pharmaceutical and nutraceutical ingredients and recently also commodity chemicals and biofuels. Here, we review the advances in modeling and synthetic biology tools and how these tools can speed up the development of yeast cell factories. We also present an overview of metabolic engineering strategies for developing yeast strains for production of polymer monomers: lactic, succinic, and cis,cis-muconic acids. S. cerevisiae has already firmly established itself as a cell factory in industrial biotechnology and the advances in yeast strain engineering will stimulate development of novel yeast-based processes for chemicals production.
authors.affiliation: The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark.
authors.forename: Irina
authors.initials: I
authors.lastname: Borodina
authors.forename: Jens
authors.initials: J
authors.lastname: Nielsen
mesh_terms: D005285:Fermentation; D007218:Industrial Microbiology; D060847:Metabolic Engineering; D009930:Organic Chemicals / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D058615:Synthetic Biology
chemical_list: D009930:Organic Chemicals
keywords: Industrial biotechnology; Metabolic engineering; Saccharomyces cerevisiae; Synthetic biology; Yeast