title: p16INK4a, NAD(+) , and sestrins: new targets for combating aging-related chronic illness?
abstract: Aging-related chronic illness is a price we have to pay to live longer. Prevalent among the oldest old, the condition limits their functional independence and also aggravates the course of several age-related chronic diseases. Thus, the search is on for efficient therapies that will mitigate age-related pathologies. In this article, we point out the potential clinical implications of recent provocative basic research in the field. New possible targets have been recently discovered, are clearly involved in age-related pathologies and might benefit the treatment of other age-related conditions, particularly metabolic diseases.
authors.affiliation: Department of Physiology, Faculty of Medicine, Universidad de Valencia, Valencia, Spain; Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain.
authors.forename: Helios
authors.initials: H
authors.lastname: Pareja-Galeano
authors.forename: Fabian
authors.initials: F
authors.lastname: Sanchis-Gomar
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002908:Chronic Disease / Q000628:therapy*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy; D009132:Muscles / Q000378:metabolism / Q000473:pathology; D009243:NAD / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D019941:Cyclin-Dependent Kinase Inhibitor p16; D006360:Heat-Shock Proteins; D009243:NAD