title: Prion protein and cancers.
abstract: The normal cellular prion protein, PrP(C) is a highly conserved and widely expressed cell surface glycoprotein in all mammals. The expression of PrP is pivotal in the pathogenesis of prion diseases; however, the normal physiological functions of PrP(C) remain incompletely understood. Based on the studies in cell models, a plethora of functions have been attributed to PrP(C). In this paper, we reviewed the potential roles that PrP(C) plays in cell physiology and focused on its contribution to tumorigenesis.
authors.affiliation: Department of the First Abdominal Surgery, Jiangxi Tumor Hospital, Nanchang 330029, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Molecular Endocrinology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Changhai Hospital of Second Military Medical University, Shanghai 200433, China.
authors.forename: Tianlin
authors.initials: T
authors.lastname: He
authors.affiliation: Department of Stomatology, The First Affiliated Hospital of Shihezi University Medical College, Shihezi 832000, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China cyli@wh.iov.cn.
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Li
mesh_terms: D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D011328:Prions / Q000472:pathogenicity* / Q000502:physiology
chemical_list: D011328:Prions
keywords: prion disease; prion protein; tumorigenesis