title: Kidney injuries related to ipilimumab.
abstract: Monoclonal antibodies directed against the immune checkpoint protein cytotoxic T-lymphocyte antigen-4 (CTLA-4; CD152) have been investigated in metastatic melanoma and other cancers and have shown promising results. Inhibition of CTLA-4 characteristically induces well-known side effects called "immune-related adverse events" (irAEs). IrAEs mainly include colitis, dermatitis, hepatitis, endocrinopathies; uveitis, iridocyclitis, neuropathies, and inflammatory myopathy have occasionally been reported. Kidney involvement is rare. We report 2 cases of acute granulomatous interstitial nephritis and present, based on literature review, renal disorders related to Ipilimumab therapy. Autoimmune symptoms have to be carefully checked for patients treated with CTLA-4 inhibitors. In order to reduce the risk of sequelae, early recognition of irAEs and treatment initiation are crucial.
authors.affiliation: Department of Nephrology, Pitie-Salpetriere, 47-80 Boulevard de l'Hôpital, 75013, Paris, France, hassan.izzedine@psl.aphp.fr.
authors.forename: Hassane
authors.initials: H
authors.lastname: Izzedine
authors.forename: Victor
authors.initials: V
authors.lastname: Gueutin
authors.forename: Chems
authors.initials: C
authors.lastname: Gharbi
authors.forename: Christine
authors.initials: C
authors.lastname: Mateus
authors.forename: Caroline
authors.initials: C
authors.lastname: Robert
authors.forename: Emilie
authors.initials: E
authors.lastname: Routier
authors.forename: Marina
authors.initials: M
authors.lastname: Thomas
authors.forename: Alain
authors.initials: A
authors.lastname: Baumelou
authors.forename: Philippe
authors.initials: P
authors.lastname: Rouvier
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D060908:CTLA-4 Antigen / Q000037:antagonists & inhibitors; D005260:Female; D006801:Humans; D000074324:Ipilimumab; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
chemical_list: D000911:Antibodies, Monoclonal; D060908:CTLA-4 Antigen; D000074324:Ipilimumab