title: Comparison of the serum immunoglobulin IgM level in diabetic and nondiabetic patients with chronic periodontitis.
abstract: OBJECTIVE
  To evaluate and compare the serum IgM level in diabetic and nondiabetic patients with chronic periodontitis.
  
  
  METHODS
  A total of 60 patients were selected for the study and divided into four groups, diabetic with periodontitis, diabetic without periodontitis, nondiabetic with periodontitis and nondiabetic without periodontitis (control) were analyzed for the quantitative estimation of serum immunoglobulins M by turbidimetric immunoassay. The serum of the diabetic and nondiabetic patients was evaluated and turbidimetric method was used for immunological assay by using Quantia IgM turbidimetric immunoassay for estimation of immunoglobulin IgM in human serum. The data for the level of immunoglobulin thus obtained were compared with clinically healthy patient taken as control. Sugar level was estimated the by checking the random blood sugar level by glucose test kit based on end point and kinetic assay and compared with the HbA1c percentage of the patients, by using NycoCard Reader.
  
  
  RESULTS
  The group A patients having diabetes with periodontitis showed nonsignifcant increase in serum IgM level as compared to controls and other groups. Group B showed signifcance of p = 0.074. Group C showed signifcance of p = 0.982 and group D showed signifcance of p = 0.520. There was signifcant increase in HbA1c with an increase percentage serum IgM.
  
  
  CONCLUSIONS
  In the present study, significantly high concentrations of the IgM in serum of diabetic and nondiabetic patients were found as compared to the healthy subjects who had neither diabetes nor periodontitis. CLINICAL SIGNIFCANCE: By this study, we can emphasize on the fact of the importance of the immune system and its correlation with glycemic control, especially in patients diagnosed with periodontitis, also suggests that the alteration in immune response in poorly controlled diabetic patients may contribute to the pathogenesis of periodontitis and is the cause of increased incidence of periodontitis in patients with diabetes.
authors.affiliation: Professor, Department of Periodontics, Consultant Periodontist, HSRM Dental College and Hospital, Hingali, Maharashtra, India.
authors.forename: J
authors.initials: J
authors.lastname: Kranthi
authors.affiliation: Professor, Department of Oral and Maxillofacial Surgery, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha, India.
authors.forename: Knv
authors.initials: K
authors.lastname: Sudhakar
authors.affiliation: Research Scholar, Department of Microbiology, MATS University Raipur, Chhattisgarh, India, e-mail: reena_2k5@rediffmail.com.
authors.forename: Reena
authors.initials: R
authors.lastname: Kulshrestha
authors.affiliation: Professor, Department of Periodontics, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha, India.
authors.forename: Pv Krishnam
authors.initials: PK
authors.lastname: Raju
authors.affiliation: Reader, Department of Conservative Dentistry and Endodontics Rungta College of Dental Sciences and Research, Bhilai, Chhattisgarh India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Razdan
authors.affiliation: Reader, Department of Periodontics, Rungta College of Dental Sciences and Research, Bhilai, Chhattisgarh, India.
authors.forename: Ts
authors.initials: Ts
authors.lastname: Srinivasa
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D055113:Chronic Periodontitis / Q000097:blood / Q000150:complications* / Q000276:immunology; D003124:Colorimetry / Q000379:methods; D048909:Diabetes Complications / Q000097:blood* / Q000276:immunology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007118:Immunoassay; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry / Q000379:methods; D017622:Periodontal Attachment Loss / Q000097:blood / Q000150:complications; D010514:Periodontal Pocket / Q000097:blood / Q000150:complications
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007075:Immunoglobulin M