title: Highly enantioselective Michael addition of diethyl malonate to chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors.
abstract: Chalcones are still challenge substrates in Michael reactions, and only limited success has been achieved. This work describes a highly enantioselective Michael addition of diethyl malonate with chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors.
authors.affiliation: Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, P. R. China. weihechem@fmmu.edu.cn.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Liu
authors.forename: Xie
authors.initials: X
authors.lastname: Wang
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: He
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D047188:Chalcones / Q000737:chemistry*; D002930:Cinchona Alkaloids / Q000737:chemistry*; D006860:Hydrogen Bonding; D008314:Malonates / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000588:Amines; D047188:Chalcones; D002930:Cinchona Alkaloids; D008314:Malonates; C498810:diethyl malonate; D013890:Thiourea