title: Expression of a novel recombinant fusion protein BVN-Tβ4 and its effects on diabetic wound healing.
abstract: A recombinant fusion protein BVN-Tβ4 is successfully expressed in Escherichia coli, purified in the laboratory and applied onto the wounds of diabetic mice to investigate its effects on diabetic wound healing. Our results show that the recombinant protein BVN-Tβ4 can promote diabetic wound healing in the murine model.
authors.affiliation: School of Life Science and Technology, Shangqiu Normal University, Shangqiu 476000, China.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: School of Environment and Planning, Shangqiu Normal University, Shangqiu 476000, China.
authors.forename: Shuna
authors.initials: S
authors.lastname: Jiang
authors.affiliation: School of Life Science and Technology, Shangqiu Normal University, Shangqiu 476000, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Ma
authors.affiliation: School of Life Science and Technology, Zhoukou Normal University, Zhoukou 466000, China. Electronic address: sqlichengwei@163.com.
authors.forename: Chengwei
authors.initials: C
authors.lastname: Li
mesh_terms: D029845:Amphibian Proteins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D048909:Diabetes Complications / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D015552:Injections, Intralesional; D051379:Mice; D008969:Molecular Sequence Data; D011898:Ranidae; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D012883:Skin Ulcer / Q000473:pathology / Q000628:therapy*; D013311:Streptozocin; D013947:Thymosin / Q000235:genetics / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*; D000099201:Thymosin beta(4)
chemical_list: D029845:Amphibian Proteins; D023181:Antimicrobial Cationic Peptides; D011993:Recombinant Fusion Proteins; D013311:Streptozocin; D013947:Thymosin; D000099201:Thymosin beta(4); C078414:brevinin-2, Rana
keywords: BVN-Tβ4; Diabetic; Escherichia coli; Fusion protein; Wound healing