title: Concordance between prenatal ultrasound and autopsy findings in a tertiary center.
abstract: OBJECTIVE
  The aim of this study was to evaluate the ultrasound (US)/autopsy concordance in elective termination of pregnancies (TOP) due to fetal causes.
  
  
  METHODS
  We performed a retrospective evaluation of elective TOP from 2004 to 2012. Inclusion criteria were gestational age at termination <24 weeks, fetal pathology and availability of US/autopsy data. Based on the US-autopsy concordance, cases were divided into four groups: Group 1: agreement; Group 2: autopsy confirmed all US findings but provided additional information; Group 3: autopsy didn't confirm all US findings; Group 4: disagreement.
  
  
  RESULTS
  One hundred and fifty-one patients fulfilled the inclusion criteria during the study period. Central nervous system malformations (91.5%), cardiovascular anomalies (90.2%) and renal system malformations (91.3%) were confirmed by autopsy. We found less concordance in the abdominal and musculoskeletal anomalies (61.5% and 66.7%, respectively). There were 130 (86%) fetuses in group 1, 7 in group 2 (4.6%), 3 in group 3 (1.9%) and 11 in group 4 (7.2%). In 5.29% of cases, the autopsy added relevant information to the diagnosis and counselling.
  
  
  CONCLUSIONS
  Diagnosis concordance between US and necropsy is achieved in almost 90% of cases. An autopsy may help to adjust the diagnosis and help in counselling the parents for a future pregnancy.
authors.affiliation: Fetal Medicine Service, Obstetrics, Gynecology and Reproductive Medicine Department, Institut Universitari Quirón-Dexeus, Barcelona, Spain.
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Rodriguez
authors.forename: Pilar
authors.initials: P
authors.lastname: Prats
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rodríguez
authors.forename: Victoria
authors.initials: V
authors.lastname: Cusí
authors.forename: Carmina
authors.initials: C
authors.lastname: Comas
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D001344:Autopsy; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D062606:Tertiary Care Centers / Q000706:statistics & numerical data; D016216:Ultrasonography, Prenatal