title: Ginseng is useful to enhance cardiac contractility in animals.
abstract: Ginseng has been shown to be effective on cardiac dysfunction. Recent evidence has highlighted the mediation of peroxisome proliferator-activated receptors (PPARs) in cardiac function. Thus, we are interested to investigate the role of PPARδ in ginseng-induced modification of cardiac contractility. The isolated hearts in Langendorff apparatus and hemodynamic analysis in catheterized rats were applied to measure the actions of ginseng ex vivo and in vivo. In normal rats, ginseng enhanced cardiac contractility and hemodynamic dP/dt(max) significantly. Both actions were diminished by GSK0660 at a dose enough to block PPARδ. However, ginseng failed to modify heart rate at the same dose, although it did produce a mild increase in blood pressure. Data of intracellular calcium level and Western blotting analysis showed that both the PPARδ expression and troponin I phosphorylation were raised by ginseng in neonatal rat cardiomyocyte. Thus, we suggest that ginseng could enhance cardiac contractility through increased PPARδ expression in cardiac cells.
authors.affiliation: Department of Neurosurgery, Taipei Medical University-Shuang Ho Hospital and College of Medicine, Taipei Medical University, Taipei 10361, Taiwan.
authors.forename: Jia-Wei
authors.identifier: 0000-0002-3311-5379
authors.initials: JW
authors.lastname: Lin
authors.affiliation: Department of Anesthesiology, Taipei Medical University-Shuang Ho Hospital and College of Medicine, Taipei Medical University, Taipei 10361, Taiwan.
authors.forename: Yih-Giun
authors.initials: YG
authors.lastname: Cherng
authors.affiliation: Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
authors.forename: Li-Jen
authors.initials: LJ
authors.lastname: Chen
authors.affiliation: Department of Nursing, Tzu Chi College of Technology, Hualien City 97005, Taiwan.
authors.forename: Ho-Shan
authors.initials: HS
authors.lastname: Niu
authors.affiliation: Department of Neurosurgery, Taipei Medical University-Shuang Ho Hospital and College of Medicine, Taipei Medical University, Taipei 10361, Taiwan.
authors.forename: Chen Kuei
authors.initials: CK
authors.lastname: Chang
authors.affiliation: Department of Nursing, Tzu Chi College of Technology, Hualien City 97005, Taiwan.
authors.forename: Chiang-Shan
authors.initials: CS
authors.lastname: Niu
mesh_terms: D000758:Anesthesia; D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000494:pharmacology; D066298:In Vitro Techniques; D042541:Intracellular Space / Q000378:metabolism; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism; D047494:PPAR delta / Q000378:metabolism; D005894:Panax / Q000737:chemistry*; D010766:Phosphorylation / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D017208:Rats, Wistar; D013844:Thiazoles / Q000494:pharmacology; D019210:Troponin I / Q000378:metabolism; D010636:Phenols; D013438:Sulfhydryl Compounds
chemical_list: D002118:Calcium; D047494:PPAR delta; D010936:Plant Extracts; D013844:Thiazoles; D019210:Troponin I; C479979:(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid; D010636:Phenols; D013438:Sulfhydryl Compounds