title: Human Papillomavirus (HPV)-associated Oral Cancers and Treatment Strategies.
abstract: Human papillomavirus (HPV) is known to be associated with several types of human cancer, including cervical, vulvar, vaginal, penile, anal, and head-and-neck cancers. Among these cancers, HPV-associated head-and-neck cancers, inclusive of oropharyngeal squamous cell carcinoma (OSCC) and oral cavity squamous cell carcinomas (OCSCC), have recently risen dramatically in men under 50 years old. Within 20 years, the percentage of HPV-positive OSCC in total OSCC went from less than 20% to more than 70% in the United States and some European countries. This article reviews the incidence trend and pathogenesis of HPV-associated head-and-neck cancers as well as current treatment modalities for the disease.
authors.affiliation: Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal - 462023, Madhya Pradesh, India.
authors.forename: N
authors.initials: N
authors.lastname: Sathish
authors.affiliation: Institute of Human Virology, Sun Yat-sen University, Guangzhou, 510081, China.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA yuan2@pobox.upenn.edu.
authors.forename: Y
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D052685:Alphapapillomavirus / Q000502:physiology*; D002294:Carcinoma, Squamous Cell / Q000628:therapy / Q000821:virology*; D002472:Cell Transformation, Viral / Q000502:physiology; D006258:Head and Neck Neoplasms / Q000628:therapy / Q000821:virology; D006801:Humans; D058990:Molecular Targeted Therapy; D009062:Mouth Neoplasms / Q000628:therapy / Q000821:virology*; D030361:Papillomavirus Infections / Q000628:therapy / Q000821:virology*
keywords: HPV vaccine; head-and-neck cancer; oral neoplasia; oral pathology; oropharyngeal squamous cell carcinoma (OSCC); treatment of head-and-neck cancers