title: Association between postmenopausal osteoporosis and experimental periodontitis.
abstract: To investigate the correlation between postmenopausal osteoporosis (PMO) and the pathogenesis of periodontitis, ovariectomized rats were generated and the experimental periodontitis was induced using a silk ligature. The inflammatory factors and bone metabolic markers were measured in the serum and periodontal tissues of ovariectomized rats using an automatic chemistry analyzer, enzyme-linked immunosorbent assays, and immunohistochemistry. The bone mineral density of whole body, pelvis, and spine was analyzed using dual-energy X-ray absorptiometry and image analysis. All data were analyzed using SPSS 13.0 statistical software. It was found that ovariectomy could upregulate the expression of interleukin- (IL-)6, the receptor activator of nuclear factor- κB ligand (RANKL), and osteoprotegerin (OPG) and downregulate IL-10 expression in periodontal tissues, which resulted in progressive alveolar bone loss in experimental periodontitis. This study indicates that changes of cytokines and bone turnover markers in the periodontal tissues of ovariectomized rats contribute to the damage of periodontal tissues.
authors.affiliation: School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiao Zhong Road, Fuzhou, Fujian 350002, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Luo
authors.affiliation: School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiao Zhong Road, Fuzhou, Fujian 350002, China.
authors.forename: Souzhi
authors.initials: S
authors.lastname: Ma
authors.affiliation: School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiao Zhong Road, Fuzhou, Fujian 350002, China.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Guo
authors.affiliation: School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiao Zhong Road, Fuzhou, Fujian 350002, China.
authors.forename: Yongling
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China.
authors.forename: Fuhua
authors.identifier: 0000-0001-5632-9487
authors.initials: F
authors.lastname: Yan
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
authors.forename: Yin
authors.identifier: 0000-0003-1785-3491
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D016301:Alveolar Bone Loss / Q000097:blood / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D015519:Bone Density; D002452:Cell Count; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008963:Molar / Q000473:pathology; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D010388:Pelvis / Q000473:pathology / Q000503:physiopathology; D010513:Periodontal Ligament / Q000473:pathology; D010518:Periodontitis / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D017207:Rats, Sprague-Dawley; D013131:Spine / Q000473:pathology / Q000503:physiopathology
chemical_list: D016207:Cytokines