title: Chronic alcohol alters rewarded behaviors and striatal plasticity.
abstract: Chronic intermittent ethanol (CIE) alters neural functions and behaviors mediated by the dorsolateral striatum (DLS) and prefrontal cortex. Here, we examined the effects of prolonged (16-bout) CIE on DLS plasticity and DLS-mediated behaviors. Ex vivo electrophysiological recordings revealed loss in efficacy of DLS synaptically induced activation and absent long-term depression after CIE. CIE increased two-bottle choice drinking and impaired Pavlovian-to-instrumental transfer but not discriminated approach. These data suggest prolonged CIE impaired DLS plasticity, to produce associated changes in drinking and cue-controlled reward-seeking. Given recent evidence that less-prolonged CIE can promote certain dorsal striatal-mediated behaviors, CIE may drive chronicity-dependent adaptations in corticostriatal systems regulating behavior.
authors.affiliation: Laboratory for Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: DePoy
authors.forename: Rachel
authors.initials: R
authors.lastname: Daut
authors.forename: Tara
authors.initials: T
authors.lastname: Wright
authors.forename: Marguerite
authors.initials: M
authors.lastname: Camp
authors.forename: Nicole
authors.initials: N
authors.lastname: Crowley
authors.forename: Bianca
authors.initials: B
authors.lastname: Noronha
authors.forename: David
authors.initials: D
authors.lastname: Lovinger
authors.forename: Andrew
authors.initials: A
authors.lastname: Holmes
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D036881:Long-Term Synaptic Depression / Q000187:drug effects; D051379:Mice; D017072:Neostriatum / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects*; D012201:Reward; D014163:Transfer, Psychology / Q000187:drug effects
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol
keywords: Alcohol; dorsolateral striatum; reward