title: Association study in three different populations between the GPR88 gene and major psychoses.
abstract: GPR88, coding for a G protein-coupled orphan receptor that is highly represented in the striatum, is a strong functional candidate gene for neuropsychiatric disorders and is located at 1p22-p21, a chromosomal region that we have previously linked to bipolar disorder (BD) in the Sardinian population. In order to ascertain the relevance of GPR88 as a risk factor for psychiatric diseases, we performed a genetic association analysis between GPR88 and BD in a sample of triads (patient and both parents) recruited in the Sardinian and the Palestinian population as well as between GPR88 and schizophrenia (SZ) in triads from the Xhosa population in South Africa. We found a positive association between GPR88 and BD in the Sardinian and Palestinian triads. Moreover, we found a positive association between GPR88 and SZ in triads from the Xhosa population in South Africa. When these results were corrected for multiple testing, the association between GPR88 and BD was maintained in the Palestinian population. Thus, these results suggest that GPR88 deserves consideration as a candidate gene for psychiatric diseases and requires to be further investigated in other populations.
authors.affiliation: Section of Neurosciences and Clinical Psychopharmacology, Department of Biomedical Sciences, University of Cagliari Cagliari, Italy ; Unit of Clinical Pharmacology, Teaching Hospital of Cagliari, AOUCA Cagliari, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Del Zompo
authors.affiliation: Sanofi 13 quai Jules Guesde, Vitry, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Deleuze
authors.affiliation: Unit of Clinical Pharmacology, Teaching Hospital of Cagliari, AOUCA Cagliari, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Chillotti
authors.affiliation: Sanofi 13 quai Jules Guesde, Vitry, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Cousin
authors.affiliation: Department of Psychiatry, Faculty of Health Sciences, Stellenbosch University Stellenbosch, South Africa.
authors.forename: Dana
authors.initials: D
authors.lastname: Niehaus
authors.affiliation: Psychology Department, National University of Singapore Singapore.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Ebstein
authors.affiliation: Unit of Clinical Pharmacology, Teaching Hospital of Cagliari, AOUCA Cagliari, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Ardau
authors.affiliation: Sanofi 13 quai Jules Guesde, Vitry, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Macé
authors.affiliation: Department of Genetics, Stellenbosch University Stellenbosch, South Africa.
authors.forename: Louise
authors.initials: L
authors.lastname: Warnich
authors.affiliation: Palestinian Research Center for Genetics of Mental Disorders, Bethlehem Mental Hospital Bethlehem, Palestine.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Mujahed
authors.affiliation: Section of Neurosciences and Clinical Psychopharmacology, Department of Biomedical Sciences, University of Cagliari Cagliari, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Severino
authors.affiliation: Sanofi 13 quai Jules Guesde, Vitry, France.
authors.forename: Colette
authors.initials: C
authors.lastname: Dib
authors.affiliation: Biostatistics Unit, Medical Research Council Bellville, South Africa.
authors.forename: Esme
authors.initials: E
authors.lastname: Jordaan
authors.affiliation: Palestinian Research Center for Genetics of Mental Disorders, Bethlehem Mental Hospital Bethlehem, Palestine.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Murad
authors.affiliation: Sanofi 13 quai Jules Guesde, Vitry, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Soubigou
authors.affiliation: Department of Psychiatry, Faculty of Health Sciences, Stellenbosch University Stellenbosch, South Africa.
authors.forename: Liezl
authors.initials: L
authors.lastname: Koen
authors.affiliation: Palestinian Research Center for Genetics of Mental Disorders, Bethlehem Mental Hospital Bethlehem, Palestine.
authors.forename: Issam
authors.initials: I
authors.lastname: Bannoura
authors.affiliation: Sanofi 13 quai Jules Guesde, Vitry, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Rocher
authors.affiliation: Department of Child and Adolescent Psychiatry, Pierre and Marie Curie Faculty of Medicine Paris, France.
authors.forename: Claudine
authors.initials: C
authors.lastname: Laurent
authors.affiliation: Sanofi 13 quai Jules Guesde, Vitry, France.
authors.forename: Murielle
authors.initials: M
authors.lastname: Derock
authors.affiliation: Department of Biotechnology and Biotherapy C.R.I.C.M. UPMC/INSERM UMR_S975/CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière (ICM) GHU Pitié-Salpêtrière, Paris, France.
authors.forename: Nicole
authors.initials: N
authors.lastname: Faucon Biguet
authors.affiliation: Department of Biotechnology and Biotherapy C.R.I.C.M. UPMC/INSERM UMR_S975/CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière (ICM) GHU Pitié-Salpêtrière, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Mallet
authors.affiliation: Department of Biotechnology and Biotherapy C.R.I.C.M. UPMC/INSERM UMR_S975/CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière (ICM) GHU Pitié-Salpêtrière, Paris, France.
authors.forename: Rolando
authors.initials: R
authors.lastname: Meloni
keywords: Candidate gene; Palestine; Sardinia; South Africa; homogeneous populations