title: A gold-catalysed imine-propargylamine cascade sequence: synthesis of 3-substituted-2,5-dimethylpyrazines and the reaction mechanism.
abstract: The gold-catalysed coupling reaction between propargylamine-derived imines and propargylamine exclusively afforded pyrazines. Besides, in order to understand the mechanism of this sequence, deuterium labeling and computational studies have been performed.
authors.affiliation: Grupo de Lactamas y Heterociclos Bioactivos, Departamento de Química Orgánica, Unidad Asociada al CSIC, Facultad de Química, Universidad Complutense de Madrid, 28040-Madrid, Spain. alcaideb@quim.ucm.es.
authors.forename: Benito
authors.initials: B
authors.lastname: Alcaide
authors.forename: Pedro
authors.initials: P
authors.lastname: Almendros
authors.forename: José M
authors.initials: JM
authors.lastname: Alonso
authors.forename: Israel
authors.initials: I
authors.lastname: Fernández
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Gómez-Campillos
authors.forename: M Rosario
authors.initials: MR
authors.lastname: Torres
mesh_terms: D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D008958:Models, Molecular; D010293:Pargyline / Q000031:analogs & derivatives* / Q000737:chemistry; D011437:Propylamines / Q000737:chemistry*; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007097:Imines; D011437:Propylamines; D011719:Pyrazines; C009054:propargylamine; D006046:Gold; D010293:Pargyline; C075524:2,5-dimethylpyrazine