title: Antibacterial activity of new oxazolidin-2-one analogues in methicillin-resistant Staphylococcus aureus strains.
abstract: Staphylococcus aureus is one of the most common causes of nosocomial infections. The purpose of this study was the synthesis and in vitro evaluation of antimicrobial activity of 10 new 3-oxazolidin-2-one analogues on 12 methicillin resistant S. aureus (MRSA) clinical isolates. S. aureus confirmation was achieved via catalase and coagulase test. Molecular characterization of MRSA was performed by amplification of the mecA gene. Antimicrobial susceptibility was evaluated via the Kirby-Bauer disc diffusion susceptibility test protocol, using commonly applied antibiotics and the oxazolidinone analogues. Only (R)-5-((S)-1-dibenzylaminoethyl)-1,3-oxazolidin-2-one (7a) exhibited antibacterial activity at 6.6 μg. These results, allow us to infer that molecules such as 7a can be potentially used to treat infections caused by MRSA strains.
authors.affiliation: Escuela de Ciencias de la Salud, Universidad Autónoma de Baja California, Ensenada, Baja California 22890, Mexico. jesus.cordova@uabc.edu.mx.
authors.forename: Jesús
authors.initials: J
authors.lastname: Córdova-Guerrero
authors.affiliation: Centro de Graduados e Investigación en Química, Instituto Tecnológico de Tijuana, Tijuana, Baja California 22000, Mexico. ehgm10@hotmail.com.
authors.forename: Esteban
authors.initials: E
authors.lastname: Hernández-Guevara
authors.affiliation: Centro de Graduados e Investigación en Química, Instituto Tecnológico de Tijuana, Tijuana, Baja California 22000, Mexico. Sandy_denys@hotmail.com.
authors.forename: Sandy
authors.initials: S
authors.lastname: Ramírez-Zatarain
authors.affiliation: Escuela de Ciencias de la Salud, Universidad Autónoma de Baja California, Ensenada, Baja California 22890, Mexico. bautistamk8814@hotmail.com.
authors.forename: Marco
authors.initials: M
authors.lastname: Núñez-Bautista
authors.affiliation: Centro de Graduados e Investigación en Química, Instituto Tecnológico de Tijuana, Tijuana, Baja California 22000, Mexico. ochoa@tectijuana.mx.
authors.forename: Adrián
authors.initials: A
authors.lastname: Ochoa-Terán
authors.affiliation: Escuela de Ciencias de la Salud, Universidad Autónoma de Baja California, Ensenada, Baja California 22890, Mexico. ramusal@uabc.edu.mx.
authors.forename: Raquel
authors.initials: R
authors.lastname: Muñiz-Salazar
authors.affiliation: Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa 80010, Mexico. julmontes@gmail.com.
authors.forename: Julio
authors.initials: J
authors.lastname: Montes-Ávila
authors.affiliation: Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa 80010, Mexico. gabylpz06@gmail.com.
authors.forename: Gabriela
authors.initials: G
authors.lastname: López-Angulo
authors.affiliation: Escuela de Ciencias de la Salud, Universidad Autónoma de Baja California, Ensenada, Baja California 22890, Mexico. arpaniagua@hotmail.com.
authors.forename: Armando
authors.initials: A
authors.lastname: Paniagua-Michel
authors.affiliation: Escuela de Ciencias de la Salud, Universidad Autónoma de Baja California, Ensenada, Baja California 22890, Mexico. gus_aryam19@hotmail.com.
authors.forename: Gustavo A Nuño
authors.initials: GA
authors.lastname: Torres
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D001426:Bacterial Proteins / Q000235:genetics; D052978:Disk Diffusion Antimicrobial Tests; D024901:Drug Resistance, Multiple, Bacterial; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D023303:Oxazolidinones / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology*; D046915:Penicillin-Binding Proteins; D011500:Protein Synthesis Inhibitors / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy*; D018440:beta-Lactam Resistance / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D023303:Oxazolidinones; D046915:Penicillin-Binding Proteins; D011500:Protein Synthesis Inhibitors; C487789:mecA protein, Staphylococcus aureus