title: Assessment of the effects of antihistamine drugs on mood, sleep quality, sleepiness, and dream anxiety.
abstract: OBJECTIVE
  There are limited comparative studies on classic and new-generation antihistamines that affect sleep quality and mood. The purpose of this study was to determine and compare the effects of classic and new-generation antihistamines on sleep quality, daytime sleepiness, dream anxiety, and mood.
  
  
  METHODS
  Ninety-two patients with chronic pruritus completed study in the dermatology outpatient clinic. Treatments with regular recommended therapeutic doses were administered. The effects of antihistaminic drugs on mood, daytime sleepiness, dream anxiety, and sleep quality were assessed on the first day and 1 month after.
  
  
  RESULTS
  Outpatients who received cetirizine and hydroxyzine treatments reported higher scores on the depression, anxiety, and fatigue sub-scales than those who received desloratadine, levocetirizine, and rupatadine. Pheniramine and rupatadine were found to be associated with daytime sleepiness and better sleep quality. UKU side effects scale scores were significantly elevated among outpatients receiving pheniramine. Classic antihistamines increased daytime sleepiness and decreased the sleep quality scores. New-generation antihistamines reduced sleep latency and dream anxiety, and increased daytime sleepiness and sleep quality.
  
  
  CONCLUSIONS
  Both antihistamines, significantly increased daytime sleepiness and nocturnal sleep quality. Daytime sleepiness was significantly predicted by rupadatine and pheniramine treatment. Cetirizine and hydroxyzine, seem to have negative influences on mood states. Given the extensive use of antihistamines in clinical settings, these results should be more elaborately examined in further studies.
authors.affiliation: Department of Psychiatry, Yuzuncu Yil University Medicine Faculty , Van , Turkey.
authors.forename: Pinar Guzel
authors.initials: PG
authors.lastname: Ozdemir
authors.forename: Ayşe Serap
authors.initials: AS
authors.lastname: Karadag
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Selvi
authors.forename: Murat
authors.initials: M
authors.lastname: Boysan
authors.forename: Serap Gunes
authors.initials: SG
authors.lastname: Bilgili
authors.forename: Adem
authors.initials: A
authors.lastname: Aydin
authors.forename: Sevda
authors.initials: S
authors.lastname: Onder
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects*; D001007:Anxiety / Q000139:chemically induced; D003863:Depression / Q000139:chemically induced; D004325:Dreams / Q000187:drug effects*; D005221:Fatigue / Q000139:chemically induced; D005260:Female; D006634:Histamine H1 Antagonists / Q000009:adverse effects* / Q000494:pharmacology* / Q000627:therapeutic use; D039563:Histamine H1 Antagonists, Non-Sedating / Q000009:adverse effects* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011537:Pruritus / Q000188:drug therapy; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects*; D055815:Young Adult
chemical_list: D006634:Histamine H1 Antagonists; D039563:Histamine H1 Antagonists, Non-Sedating
keywords: Antihistamines; daytime sleepiness; dream anxiety; mood; sleep quality