title: Hormone abnormalities are not related to the erectile dysfunction and decreased libido found in many men with infertility.
abstract: OBJECTIVE
  To evaluate whether hormonal markers predict erectile dysfunction (ED) and symptoms of T deficiency syndrome (TDS), which are commonly found in the population of infertile men.
  
  
  METHODS
  Retrospective study utilizing a prospectively maintained infertility database.
  
  
  METHODS
  A tertiary referral center.
  
  
  METHODS
  A total of 1,750 of 2,783 men presenting for evaluation of infertility between 1995 and 2010 completed validated questionnaires.
  
  
  METHODS
  Androgen Deficiency in the Aging Male (ADAM) and Sexual Health Inventory for Men questionnaires were administered. Baseline risk factors for ED and TDS were also measured. Subjects underwent serum hormone evaluation for total T, calculated bioavailable T, sex hormone-binding globulin, E2, LH, FSH, and PRL.
  
  
  METHODS
  Multivariable logistic regression modeling was used to determine the significance of hormonal markers in predicting ED (Sexual Health Inventory for Men score <22) and/or a positive ADAM score.
  
  
  RESULTS
  The prevalence of ED and a positive response to the ADAM questionnaire were 30.5% and 45.2%, respectively, in this population (mean age, 36 years). Low serum T (total T < 10 nmol/L) was found in 29.4%. Neither T nor bioavailable T was significantly associated with the symptoms of ED or TDS on multivariable regression analysis.
  
  
  CONCLUSIONS
  Erectile dysfunction and TDS in young, infertile men seem to be unrelated to hormone changes.
authors.affiliation: Division of Urology, Department of Surgery, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada; Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: Raj
authors.initials: R
authors.lastname: Satkunasivam
authors.affiliation: Division of Urology, Department of Surgery, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Ordon
authors.affiliation: Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: Brian
authors.initials: B
authors.lastname: Hu
authors.affiliation: Department of Pathology and Laboratory Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
authors.forename: Brendan
authors.initials: B
authors.lastname: Mullen
authors.affiliation: Division of Urology, Department of Surgery, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Kirk
authors.initials: K
authors.lastname: Lo
authors.affiliation: Division of Urology, Department of Surgery, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
authors.forename: Ethan
authors.initials: E
authors.lastname: Grober
authors.affiliation: Division of Urology, Department of Surgery, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada. Electronic address: KJarvi@mtsinai.on.ca.
authors.forename: Keith
authors.initials: K
authors.lastname: Jarvi
mesh_terms: D047649:Andropause; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D007172:Erectile Dysfunction / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D007248:Infertility, Male / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D007989:Libido; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D009864:Ontario / Q000453:epidemiology; D010410:Penile Erection; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D062606:Tertiary Care Centers; D013739:Testosterone / Q000097:blood / Q000172:deficiency*
chemical_list: D015415:Biomarkers; D013739:Testosterone
keywords: Infertility; andropause; erectile dysfunction