title: Effect of mydriasis induced by topical 0.5% tropicamide instillation on the corneal biomechanical properties in healthy individuals measured by ocular response analyzer.
abstract: OBJECTIVE
  This observational study aims to investigate the effects of tropicamide (0.5%) on corneal biomechanical properties, with the ocular response analyzer (ORA), in healthy individuals.
  
  
  METHODS
  Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) measurements of 38 (21 female and 17 male) healthy individuals, before and after 30 min of 0.5% tropicamide instillation, were performed by using the ORA.
  
  
  RESULTS
  The mean CH, CRF, IOPg and IOPcc measurements of the eyes were 10.2 ± 1.9 mmHg, 10.3 ± 2.1 mmHg, 15.7 ± 3.4 mmHg, 16.4 ± 3.3 mmHg pre-tropicamide, and 10.4 ± 1.7 mmHg, 10.3 ± 2.1 mmHg, 15.3 ± 3.4 mmHg, 15.8 ± 2.7 mmHg post-tropicamide, respectively. The differences between the pre- and post-tropicamide measurements of the eyes were insignificant (p = 0.184, p = 0.659, p = 0.294, p = 0.150, respectively; paired t-test).
  
  
  CONCLUSIONS
  A tropicamide instillation does not lead to significant changes in the corneal biomechanical properties. Therefore, it can be used safely in disease, i.e. in the diagnosis and follow-up ORA as it does not cause any change.
authors.affiliation: Department of Ophthalmology, Necmettin Erbakan University School of Medicine , Konya , Turkey.
authors.forename: Refik
authors.initials: R
authors.lastname: Oltulu
authors.forename: Gunhal
authors.initials: G
authors.lastname: Satirtav
authors.forename: Orhan
authors.initials: O
authors.lastname: Altunkaya
authors.forename: Gulfidan
authors.initials: G
authors.lastname: Bitirgen
authors.forename: Mehmet
authors.initials: M
authors.lastname: Okka
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D003315:Cornea / Q000187:drug effects* / Q000502:physiology; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D015878:Mydriasis / Q000139:chemically induced*; D009184:Mydriatics / Q000494:pharmacology*; D014331:Tropicamide / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D009184:Mydriatics; D014331:Tropicamide
keywords: Corneal biomechanics; ocular response analyzer; tropicamide