title: Endeavors to access molecular complexity: strategic use of free radicals in natural product synthesis.
abstract: Free radicals, which in the past were considered unruly chemical species, have become manageable and indispensable for synthetic organic chemistry. The unique nature of free radicals has allowed practitioners in organic synthesis to design flexible approaches to produce various materials ranging from small molecules to polymers. The present Personal Account describes the author's endeavors to create molecular complexity by the strategic use of free radicals, with an emphasis on the synthesis of bioactive natural products.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. yoshimit@phs.osaka-u.ac.jp.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yoshimitsu
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis*; D004987:Ethers / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry*; D007608:Kainic Acid / Q000138:chemical synthesis / Q000737:chemistry; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000470:Alkaloids; D000596:Amino Acids; D001688:Biological Products; D004987:Ethers; D005609:Free Radicals; D023303:Oxazolidinones; D028561:Transition Elements; C464968:agelastatin A; D007608:Kainic Acid
keywords: C-H transformations; boranes; natural products; radical reactions; total synthesis