title: Construction of multi-scale common brain networks based on DICCCOL.
abstract: Modeling the human brain as a network has been widely considered as a powerful approach to investigating the brain's structural and functional systems. However, many previous approaches focused on a single scale of brain network and the multi-scale nature of brain networks has been rarely explored yet. This paper put forward a novel framework to construct multi-scale common networks of brains via multi-scale spectral clustering of fiber connections among DICCCOLs. Specifically, the recently developed and publicly released DICCCOLs provide the nodal structural and functional correspondence across individuals, and thus the employed multi-scale spectral clustering algorithm divided the DICCCOL landmarks and their connections into sub-networks with correspondences on multiple scales. Experimental results showed the promise of the constructed multi-scale networks in applications of structural and functional connectivity mapping. As an application example, these multi-scale networks are used to guide the identification of multi-scale common fiber bundles across individuals and to facilitate the bundle's functional role analysis, which could enable other tract-based and network-based analyses in the future.
authors.forename: Bao
authors.initials: B
authors.lastname: Ge
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Dajiang
authors.initials: D
authors.lastname: Zhu
authors.forename: Tuo
authors.initials: T
authors.lastname: Zhang
authors.forename: Xintao
authors.initials: X
authors.lastname: Hu
authors.forename: Junwei
authors.initials: J
authors.lastname: Han
authors.forename: Tianming
authors.initials: T
authors.lastname: Liu
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology*; D063132:Connectome / Q000379:methods*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D009415:Nerve Net / Q000033:anatomy & histology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity