title: [Instrumental and ethical aspects of experimental research with animal models].
abstract: Experimental animal models offer possibilities of physiology knowledge, pathogenesis of disease and action of drugs that are directly related to quality nursing care. This integrative review describes the current state of the instrumental and ethical aspects of experimental research with animal models, including the main recommendations of ethics committees that focus on animal welfare and raises questions about the impact of their findings in nursing care. Data show that, in Brazil, the progress in ethics for the use of animals for scientific purposes was consolidated with Law No. 11.794/2008 establishing ethical procedures, attending health, genetic and experimental parameters. The application of ethics in handling of animals for scientific and educational purposes and obtaining consistent and quality data brings unquestionable contributions to the nurse, as they offer subsidies to relate pathophysiological mechanisms and the clinical aspect on the patient.
authors.affiliation: University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Mirian
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Cassiane Dezoti
authors.initials: CD
authors.lastname: da Fonseca
authors.affiliation: University of Sao Paulo, School of Nursing, Sao Paulo, Brazil.
authors.forename: Maria de Fatima Fernandes
authors.initials: Mde F
authors.lastname: Vattimo
mesh_terms: D035661:Animal Care Committees; D032761:Animal Experimentation / Q000941:ethics*; D000818:Animals; D023421:Models, Animal