title: The role of 18F-FDG-PET and PET/CT in patients with colorectal liver metastases undergoing selective internal radiation therapy with yttrium-90: a first evidence-based review.
abstract: OBJECTIVE
  To provide a first evidence-based review of the literature on the role of fluorine-18-fluorodeoxyglucose positron emission tomography and positron emission tomography/computed tomography (FDG-PET and PET/CT) in patients with colorectal liver metastases (CRLM) undergoing selective internal radiation therapy (SIRT) with yttrium-90 ((90)Y) microspheres.
  
  
  METHODS
  A comprehensive computer literature search was conducted to find relevant published articles on whole-body FDG-PET or PET/CT in patients with CRLM undergoing SIRT.
  
  
  RESULTS
  We identified 19 studies including 833 patients with CRLM undergoing SIRT. The role of FDG-PET or PET/CT was analysed in treatment planning, treatment response evaluation, and as prognostic tool.
  
  
  CONCLUSIONS
  FDG-PET and PET/CT provide additional information in treatment evaluation of CRLM patients treated with SIRT and may have a role in treatment planning and patient selection. FDG-PET/CT is emerging as good prognostic tool in these patients.
authors.affiliation: Department of Bioimaging and Radiological Sciences, Institute of Nuclear Medicine, Catholic University of the Sacred Heart, Largo Agostino Gemelli 8, 00168 Rome, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Annunziata
authors.affiliation: Department of Nuclear Medicine and PET Center, Oncology Institute of Southern Switzerland, via Ospedale 12, 6500 Bellinzona, Switzerland.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Treglia
authors.affiliation: Department of Bioimaging and Radiological Sciences, Institute of Nuclear Medicine, Catholic University of the Sacred Heart, Largo Agostino Gemelli 8, 00168 Rome, Italy.
authors.forename: Carmelo
authors.identifier: 0000-0002-1047-3333
authors.initials: C
authors.lastname: Caldarella
authors.affiliation: School of Medicine, Catholic University of the Sacred Heart, Largo Agostino Gemelli 8, 00168 Rome, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Galiandro
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary*; D049268:Positron-Emission Tomography; D011379:Prognosis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes
chemical_list: D015021:Yttrium Radioisotopes; D019788:Fluorodeoxyglucose F18