title: Familial chylomicronemia syndrome related chronic pancreatitis: a single-center study.
abstract: BACKGROUND
  Hypertriglyceridemia induces acute recurrent pancreatitis, but its role in the etiology of chronic pancreatitis (CP) is controversial. This study aimed to evaluate the clinical, laboratory and radiological findings of 7 patients with CP due to type 1 hyperlipidemia compared to CP patients with other or undefined etiological factors.
  
  
  METHODS
  We retrospectively analyzed the clinical, laboratory and radiological findings of 7 CP patients with type 1 hyperlipidemia compared to CP patients without hypertriglyceridemia. These 7 patients had multiple episodes of acute pancreatitis and had features of CP on abdominal CT, endoscopic retrograde cholangiopancreatography and/or endoscopic ultrasonography.
  
  
  RESULTS
  All CP patients were classified into two groups: a group with type 1 hyperlipidemia (n=7) and a group with other etiologies (n=58). The mean triglyceride level was 2323+/-894 mg/dL in the first group. Age at the diagnosis of CP in the first group was significantly younger than that in the second group (16.5+/-5.9 vs 48.3+/-13.5, P<0.001). The number of episodes of acute pancreatitis in the first group was significantly higher than that in the second group (15.0+/-6.8 vs 4.0+/-4.6, P=0.011). The number of splenic vein thrombosis in the first group was significantly higher than that in the second group (4/7 vs 9/58, P=0.025). Logistic regression analysis found that younger age was an independent predictor of CP due to hypertriglyceridemia (r=0.418, P=0.000).
  
  
  CONCLUSIONS
  Type 1 hyperlipidemia appears to be an etiological factor even for a minority of patients with CP. It manifests at a younger age, and the course of the disease might be severe.
authors.affiliation: Division of Gastroenterology, Istanbul University Cerrahpasa Medical Faculty, Istanbul 34100, Turkey. dryusuferzin@yahoo.com.
authors.forename: Gurhan
authors.initials: G
authors.lastname: Sisman
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Erzin
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Hatemi
authors.forename: Erkan
authors.initials: E
authors.lastname: Caglar
authors.forename: Salih
authors.initials: S
authors.lastname: Boga
authors.forename: Vikesh
authors.initials: V
authors.lastname: Singh
authors.forename: Hakan
authors.initials: H
authors.lastname: Senturk
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D002648:Child; D002760:Cholangiopancreatography, Endoscopic Retrograde; D019160:Endosonography; D005260:Female; D006801:Humans; D008072:Hyperlipoproteinemia Type I / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D050500:Pancreatitis, Chronic / Q000175:diagnosis / Q000209:etiology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D014280:Triglycerides / Q000097:blood; D014421:Turkey; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014280:Triglycerides