title: Meta-analysis of infectious agents and depression.
abstract: Depression is a debilitating psychiatric disorder and a growing global public health issue. However, the relationships between microbial infections and depression remains uncertain. A computerized literature search of Medline, ISI Web of Knowledge, PsycINFO, and the Cochrane Library was conducted up to May 2013, and 6362 studies were initially identified for screening. Case-control studies detected biomarker of microorganism were included. Based on inclusion and exclusion criteria, 28 studies were finally included to compare the detection of 16 infectious agents in unipolar depressed patients and healthy controls with a positive incident being defined as a positive biochemical marker of microbial infection. A customized form was used for data extraction. Pooled analysis revealed that the majority of the 16 infectious agents were not significantly associated with depression. However, there were statistically significant associations between depression and infection with Borna disease virus, herpes simplex virus-1, varicella zoster virus, Epstein-Barr virus, and Chlamydophila trachomatis.
authors.affiliation: 1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3].
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: 1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [4].
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: 1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [4].
authors.forename: Yang
authors.initials: Y
authors.lastname: Lei
authors.affiliation: 1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [4].
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.affiliation: 1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Zhou
authors.affiliation: 1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: 1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Mingju
authors.initials: M
authors.lastname: Wang
authors.affiliation: 1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: 1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China.
authors.forename: Lujun
authors.initials: L
authors.lastname: Zhang
authors.affiliation: 1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Songhua
authors.initials: S
authors.lastname: Fan
authors.affiliation: 1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xie
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D023501:Chlamydophila; D023521:Chlamydophila Infections / Q000150:complications / Q000378:metabolism; D003141:Communicable Diseases / Q000150:complications* / Q000378:metabolism; D003863:Depression / Q000209:etiology* / Q000382:microbiology*; D006801:Humans; D014780:Viruses
chemical_list: D015415:Biomarkers