title: Preparing to unwind.
abstract: A combination of protein crystallography and biochemistry has revealed how a ring-shaped helicase might trap a single DNA strand as the double helix melts, and before it is unwound.
authors.affiliation: Jin Chuan Zhou is at the London Research Institute, Cancer Research UK, Clare Hall Laboratories, London, United Kingdom.
authors.forename: Jin Chuan
authors.initials: JC
authors.lastname: Zhou
authors.forename: Alessandro
authors.initials: A
authors.lastname: Costa
mesh_terms: D017124:Conserved Sequence; D004261:DNA Replication / Q000502:physiology*; D004277:DNA, Single-Stranded / Q000378:metabolism*; D064110:Minichromosome Maintenance Proteins / Q000502:physiology*
chemical_list: D004277:DNA, Single-Stranded; D064110:Minichromosome Maintenance Proteins
keywords: DNA replication; archaea; biochemistry; crystallography; helicase