title: Cytotoxic reaction mediators: granzymes A and B in women with ovarian cancer.
abstract: The purpose of this work was the assessment of cytotoxic reaction mediators - granzymes A and B in the serum of women with ovarian tumors. The study included 120 women with proven ovarian tumors. The control group consisted of 60 healthy women in whom no pathological changes within the reproductive system were detected. Concentrations of granzymes A and B were measured by enzyme-linked immunosorbent (ELISA) assay. The highest concentrations of the studied parameters were observed in serum of women with ovarian cancer. Moreover, the concentrations of granzymes A and B in patients with ovarian cancer were substantially increased in comparison to concentrations in patients with ovarian cystadenomas (P < 0.0001) or ovarian teratomas (P < 0.0001).
authors.affiliation: Department of Immunology and Serology, Medical University of Silesia, Katowice, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Mielczarek-Palacz
authors.forename: J
authors.initials: J
authors.lastname: Sikora
authors.forename: Z
authors.initials: Z
authors.lastname: Kondera-Anasz
authors.forename: I
authors.initials: I
authors.lastname: Bednarek
mesh_terms: D000328:Adult; D017209:Apoptosis; D018394:CA-125 Antigen / Q000097:blood; D016022:Case-Control Studies; D018284:Cystadenocarcinoma, Serous / Q000097:blood* / Q000276:immunology; D018293:Cystadenoma, Serous / Q000097:blood* / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D053804:Granzymes / Q000097:blood*; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000201:enzymology / Q000276:immunology; D008593:Menopause / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D010051:Ovarian Neoplasms / Q000097:blood* / Q000276:immunology; D013724:Teratoma / Q000097:blood* / Q000276:immunology; D055815:Young Adult
chemical_list: D018394:CA-125 Antigen; D009363:Neoplasm Proteins; D053804:Granzymes
keywords: granzyme A; granzyme B; ovarian cancer