title: Synthesis and biological activity of quaternary ammonium salt-type agents containing cholesterol and terpenes.
abstract: New quaternary ammonium salt-type compounds with lipophilic cholesterol and terpene moieties were synthesized. The compounds showed promising antibacterial and antimycobacterial activities. Those compounds containing the cholesterol moiety showed significant activity against Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus faecium. On the contrary, the antimycobacterial activity increased with the presence of the terpene unit in the molecule.
authors.affiliation: Faculty of Pharmacy in Hradec Králové, Department of Biochemical Sciences, Charles University in Prague, Hradec Králové, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Novotná
authors.forename: Karel
authors.initials: K
authors.lastname: Waisser
authors.forename: Jiří
authors.initials: J
authors.lastname: Kuneš
authors.forename: Karel
authors.initials: K
authors.lastname: Palát
authors.forename: Vladimír
authors.initials: V
authors.lastname: Buchta
authors.forename: Jiřina
authors.initials: J
authors.lastname: Stolaříková
authors.forename: Rainer
authors.initials: R
authors.lastname: Beckert
authors.forename: Vladimír
authors.initials: V
authors.lastname: Wsól
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002784:Cholesterol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D016984:Enterococcus faecium / Q000187:drug effects / Q000254:growth & development; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects / Q000254:growth & development; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000644:Quaternary Ammonium Compounds; D013729:Terpenes; D002784:Cholesterol
keywords: Antibacterial activity; Antifungal activity; Cholesterol; Terpenes; Tuberculostatics