title: Transient residence of a seropositive organ is sufficient to transfer human cytomegalovirus to a seronegative recipient.
abstract: Many aspects of the pathogenesis of human cytomegalovirus (HCMV) infection in liver transplantation remain unclear. This study examined the transfer of HCMV from the transient residence of a seropositive organ in seronegative recipients. All subjects receiving >1 orthotopic liver transplant (LT) were identified from an LT database. The patients of interest were HCMV-seronegative LT recipients who received their first organ from a seropositive donor, and subsequently a second LT from a seronegative donor within 30 days. Of 98 patients identified, 6 met these criteria and 4 developed viremia; in 2 cases, after the seropositive organ was in situ for 28 and 109 h. We can therefore conclude that 28 h is sufficient to allow HCMV to transmit, but the minimum time has not yet been defined.
authors.affiliation: Centre for Virology, Division of Infection and Immunity, UCL Medical School, London, UK.
authors.forename: H A
authors.initials: HA
authors.lastname: Lumgair
authors.forename: N
authors.initials: N
authors.lastname: Rolando
authors.forename: J
authors.initials: J
authors.lastname: O'Beirne
authors.forename: D
authors.initials: D
authors.lastname: Sharma
authors.forename: P D
authors.initials: PD
authors.lastname: Griffiths
mesh_terms: D000914:Antibodies, Viral / Q000302:isolation & purification; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000097:blood / Q000635:transmission* / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000302:isolation & purification; D008099:Liver / Q000821:virology*; D016031:Liver Transplantation / Q000009:adverse effects*; D012189:Retrospective Studies; D013997:Time Factors; D014766:Viremia
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G
keywords: allograft; cytomegalovirus replication; liver