title: Ferritin H gene deletion in the choroid plexus and forebrain results in hydrocephalus.
abstract: Ferritin H, the major iron storage protein, has essential functions in early embryonic development as well as in adult liver and intestine. To address the question whether ferritin H has similarly essential functions in the brain we used the Cre/loxP system to generate mice with a forebrain-specific inactivation of the ferritin H gene. Ferritin H deficiency in most cells of the forebrain including cells of the choroid plexus caused accumulation of cerebrospinal fluid in the lateral ventricles and the subarachnoid space. Brain tissue iron content was unchanged.
authors.affiliation: Swiss Institute for Experimental Cancer Research (ISREC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
authors.forename: Claude
authors.initials: C
authors.lastname: Schweizer
authors.affiliation: Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Fraering
authors.affiliation: Swiss Institute for Experimental Cancer Research (ISREC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
authors.forename: Lukas C
authors.initials: LC
authors.lastname: Kühn
mesh_terms: D000818:Animals; D001052:Apoferritins / Q000134:cerebrospinal fluid / Q000172:deficiency / Q000235:genetics*; D002540:Cerebral Cortex / Q000378:metabolism; D002552:Cerebral Ventricles / Q000378:metabolism / Q000473:pathology; D002831:Choroid Plexus / Q000378:metabolism*; D017353:Gene Deletion; D018398:Homeodomain Proteins / Q000235:genetics; D006849:Hydrocephalus / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D007501:Iron / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D016548:Prosencephalon / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics; D000099260:Empty Spiracles Homeobox Proteins
chemical_list: D001052:Apoferritins; D018398:Homeodomain Proteins; D007501:Iron; D014157:Transcription Factors; D000099260:Empty Spiracles Homeobox Proteins
keywords: Blood brain barrier; Brain; Ferritin H; Iron; Mice