title: In vitro virucidal effect of mouthrinse containing C31G on seasonal influenza viruses.
abstract: C31G is a potent antimicrobial agent and can disrupt the microbial membrane by the alkyl portion of the molecule. The objective of this study was to evaluate the virucidal effectiveness of C31G and mouthrinse containing C31G (Sense-Time) on seasonal influenza viruses. Evaluation of the virucidal activity against influenza viruses was performed with end-point titration in 10-day-old chicken embryos and Madin-Darby canine kidney cells. In vitro studies demonstrated that C31G and Sense-Time inhibited the growth of seasonal influenza viruses even in the presence of 5% organic material. Gargling with C31G or Sense-Time would enhance oropharyngeal hygiene, which would be helpful for reducing influenza transmission.
authors.affiliation: College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Dong-Hun
authors.initials: DH
authors.lastname: Lee
authors.forename: Ha-Na
authors.initials: HN
authors.lastname: Youn
authors.forename: Jae-Keun
authors.initials: JK
authors.lastname: Park
authors.forename: Byung-Hwa
authors.initials: BH
authors.lastname: Kang
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Kang
authors.forename: Joong-Bok
authors.initials: JB
authors.lastname: Lee
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Park
authors.forename: In-Soo
authors.initials: IS
authors.lastname: Choi
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Lee
authors.forename: Chang-Seon
authors.initials: CS
authors.lastname: Song
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001622:Betaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002642:Chick Embryo; D004285:Dogs; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D061985:Madin Darby Canine Kidney Cells; D009975:Orthomyxoviridae / Q000187:drug effects*; D019562:Viral Load / Q000187:drug effects*; D014776:Virus Cultivation
chemical_list: D000998:Antiviral Agents; D005231:Fatty Acids, Unsaturated; D001622:Betaine; C038360:C 31G