title: An analysis of HLA-A, -B, and -DRB1 allele and haplotype frequencies of 21,918 residents living in Liaoning, China.
abstract: HLA-A, -B and -DRB1 allele frequencies and their haplotype frequencies in 21,918 Chinese residents living in Liaoning Province, who were registered as volunteer donors of China Marrow Donor Registry, were investigated. They are composed of 93.37% Han Chinese, 5.1% Manchus, 0.57% Mongols, 0.46% Hui persons, 0.29% Koreans and 0.14% Xibe ethnic group. In total eighteen different HLA-A alleles, forty-eight different HLA-B alleles and fourteen different HLA-DRB1 alleles have been identified. Their frequencies are in agreement with the Hardy-Weinberg equilibrium. For Han Chinese in Liaoning, 1,534 different HLA-A-B-DRB1 haplotypes were identified, with a frequency of higher than 0.01%. A*30-B*13-DRB1*07, A*02-B*46-DRB1*09 and A*02-B*13-DRB1*12 are the most frequent haplotypes among Liaoning Han. While Liaoning Han, Liaoning Manchu, Liaoning Mongol, Liaoning Hui and Liaoning Korean share the northern Han characteristic haplotypes, all minority ethnic groups with the exception of Liaoning Manchu have developed their own unique HLA profiles. This dataset characterizes the HLA allele and haplotype frequencies in the Liaoning area and suggests that it is different from those in other parts of China and ethnic groups, which implicates transplant donor searching strategies and studies on population genetics.
authors.affiliation: HLA Laboratory, Liaoning Blood Center, Shenyang, Liaoning, China; Liaoning Key Laboratory of Blood Safety Research, Shenyang, Liaoning, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Li
authors.affiliation: HLA Laboratory, Liaoning Blood Center, Shenyang, Liaoning, China; Liaoning Key Laboratory of Blood Safety Research, Shenyang, Liaoning, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: HLA Laboratory, Liaoning Blood Center, Shenyang, Liaoning, China; Liaoning Key Laboratory of Blood Safety Research, Shenyang, Liaoning, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.affiliation: HLA Laboratory, Liaoning Blood Center, Shenyang, Liaoning, China; Liaoning Key Laboratory of Blood Safety Research, Shenyang, Liaoning, China.
authors.forename: Kun-Lian
authors.initials: KL
authors.lastname: Zhang
authors.affiliation: BFR Diagnostics LTD, Beijing, China.
authors.forename: Xiang-Jun
authors.initials: XJ
authors.lastname: Liu
authors.affiliation: HLA Laboratory, Liaoning Blood Center, Shenyang, Liaoning, China; Liaoning Key Laboratory of Blood Safety Research, Shenyang, Liaoning, China; Shenyang Research Center for Stem Cell Clinical Application, Shenyang, Liaoning, China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D005843:Geography; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D008913:Minority Groups; D010802:Phylogeny; D014019:Tissue Donors; D055815:Young Adult
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059811:HLA-DRB1 Chains