title: Clinicopathological and EBV analysis of respiratory epithelial adenomatoid hamartoma.
abstract: BACKGROUND
  To investigate the clinicopathological characteristics of respiratory epithelial adenomatoid hamartoma (REAH) in residents of Southern China and to study the correlation between REAH and Epstein-Barr virus (EBV).
  
  
  METHODS
  Clinicopathological data of 53 cases of REAH were retrospectively analyzed. The immunoreactivity for CK 7, CK20, CEA, p53, and Ki-67, Alcian blue-periodic acid-Schiff (AB-PAS) staining and in situ hybridization for EBV-encoded RNA (EBER) were carried out.
  
  
  RESULTS
  REAH lesions were covered with ciliated columnar epithelium and proliferation of subepithelial glands, which were positive for CK7, and negative for CK20, CEA, and p53. Goblet cell metaplasia was stained blue by AB-PAS. The frequency of EBER positive cases in REAH located in nasopharynx was 27.78%, compared with that in the nasal cavity (15.79%) and paranasal sinuses (12.50%), there were no statistical differences.
  
  
  CONCLUSIONS
  REAH is an uncommon entity with distinctive morphologic features and EBV may have nothing to do with REAH.
  The virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/5875687401178748.
authors.forename: Xing
authors.initials: X
authors.lastname: Hua
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Huang
authors.forename: Zexiao
authors.initials: Z
authors.lastname: Liao
authors.forename: Qi
authors.initials: Q
authors.lastname: Xian
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University, 510515 Tonghe, Guangzhou, People's Republic of China. nana1800@sohu.com.
authors.forename: Lina
authors.initials: L
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D002681:China; D005260:Female; D006222:Hamartoma / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology* / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000302:isolation & purification; D020545:Respiratory Mucosa / Q000737:chemistry / Q000473:pathology* / Q000821:virology*; D012140:Respiratory Tract Diseases / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology* / Q000821:virology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012367:RNA, Viral