title: Bronchoscopic lung volume reduction with endobronchial valves for patients with heterogeneous emphysema and intact interlobar fissures (the BeLieVeR-HIFi trial): study design and rationale.
abstract: Although lung volume reduction surgery improves survival in selected patients with emphysema, there has been ongoing interest in developing and evaluating bronchoscopic approaches to try to reduce lung volumes with less morbidity and mortality. The placement of endobronchial valves is one such technique, and although some patients have had a significant improvement, responses have been inconsistent because collateral ventilation prevents lobar atelectasis. We describe the protocol of a trial (ISRCTN04761234) aimed to show that a responder phenotype, patients with heterogeneous emphysema and intact interlobar fissures on CT scanning, can be identified prospectively, leading to a consistent benefit in clinical practice.
authors.affiliation: NIHR Respiratory Disease, Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Davey
authors.affiliation: NIHR Respiratory Disease, Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, UK.
authors.forename: Z
authors.initials: Z
authors.lastname: Zoumot
authors.affiliation: NIHR Respiratory Disease, Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Jordan
authors.affiliation: NIHR Respiratory Disease, Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, UK.
authors.forename: D H
authors.initials: DH
authors.lastname: Carr
authors.affiliation: NIHR Respiratory Disease, Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, UK.
authors.forename: M I
authors.initials: MI
authors.lastname: Polkey
authors.affiliation: NIHR Respiratory Disease, Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, UK.
authors.forename: P L
authors.initials: PL
authors.lastname: Shah
authors.affiliation: NIHR Respiratory Disease, Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, UK.
authors.forename: N S
authors.initials: NS
authors.lastname: Hopkinson
mesh_terms: D001980:Bronchi / Q000601:surgery*; D001999:Bronchoscopy; D004311:Double-Blind Method; D005541:Forced Expiratory Volume; D006801:Humans; D008176:Lung Volume Measurements; D019736:Prostheses and Implants / Q000009:adverse effects; D019919:Prosthesis Implantation; D011656:Pulmonary Emphysema / Q000503:physiopathology / Q000601:surgery*; D012107:Research Design
keywords: Emphysema; Lung Volume Reduction Surgery