title: Three alkaloids from Reineckia carnea herba and their antitussive and expectorant activities.
abstract: Three alkaloids, (3-chloro-2-hydroxypropyl) trimethylammonium chloride (1), p-(acetylamino)-phenol (2) and 4,4'-diacetamidodiphenyl ether (3), were isolated from Reineckia carnea herba. Their structures were determined by detailed analysis of their 1D and 2D NMR spectra and MS. Compounds 1 and 3 were new natural products. Compound 2 was isolated for the first time from the Reineckia genus. Compound 1 displayed significant in vivo antitussive and expectorant activities.
authors.affiliation: a Development and Utilization Key Laboratory of Northeast Plant Materials , School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Na
authors.initials: N
authors.lastname: Han
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.forename: Yichun
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000627:Aminophenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000996:Antitussive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003371:Cough / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005100:Expectorants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019668:Liliaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010647:Phenyl Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D020005:Propanols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000627:Aminophenols; D000996:Antitussive Agents; D004365:Drugs, Chinese Herbal; D005100:Expectorants; D010647:Phenyl Ethers; D020005:Propanols; D000644:Quaternary Ammonium Compounds; C000593094:p-(acetylamino)phenol; C496948:(3-chloro-2-hydroxypropyl)trimethylammonium chloride; C000593093:4,4'-diacetamidodiphenyl ether
keywords: Reineckia carnea; alkaloid; antitussive; expectorant