title: Antiproliferative effects of 12-oxoheteronemin vs heteronemin.
abstract: The antiproliferative activities of 12-oxoheteronemin and heteronemin were evaluated in six cancer cell lines and IC50 values ranging from 0.66 to 1.35 microM were obtained. In four of the cell lines, 12-oxoheteronemin and heteronemin were equipotent; however, in two estrogenic receptor-positive cell lines, heteronemin showed a stronger potency. Both compounds had no overt effects on cell cycle distribution in HeLa cells, but did rapidly initiate apoptosis as evidenced by increased sub-G1 populations of cells and caspase-dependent PARP cleavage.
authors.forename: Siriporn
authors.initials: S
authors.lastname: Kittiwisut
authors.forename: Cristina C
authors.initials: CC
authors.lastname: Rohena
authors.forename: Supreeya
authors.initials: S
authors.lastname: Yuenyongsawad
authors.forename: Susan L
authors.initials: SL
authors.lastname: Mooberry
authors.forename: Anuchit
authors.initials: A
authors.lastname: Plubrukarn
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D013729:Terpenes / Q000494:pharmacology*
chemical_list: C588199:12-oxoheteronemin; D013729:Terpenes; C493748:heteronemin