title: Genomic alterations in pulmonary adenocarcinoma in situ in an adolescent patient.
abstract: Lung cancer is a rare event in the pediatric and adolescent population. To date, only a few case reports and small case series have been published, and little is known about the risk factors associated with this entity in children and adolescents. We describe a case of adenocarcinoma in situ in a 15-year-old adolescent girl with previous surgical treatment for malignant melanoma. We provide a detailed genomic characterization of this neoplasm by comparative genomic hybridization, genome-wide single-nucleotide polymorphism array, and fluorescence in situ hybridization analyses. We identify chromosomal regions with copy number changes and correlate the corresponding genes within these regions with the available literature in the area.
authors.affiliation: From the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
authors.forename: Marcela
authors.initials: M
authors.lastname: Salomao
authors.forename: Brynn
authors.initials: B
authors.lastname: Levy
authors.forename: Odelia
authors.initials: O
authors.lastname: Nahum
authors.forename: Jinli
authors.initials: J
authors.lastname: Chen
authors.forename: Mahesh
authors.initials: M
authors.lastname: Mansukhani
authors.forename: Alain C
authors.initials: AC
authors.lastname: Borczuk
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000293:Adolescent; D002278:Carcinoma in Situ / Q000235:genetics / Q000473:pathology; D002869:Chromosome Aberrations; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D055028:Comparative Genomic Hybridization; D056915:DNA Copy Number Variations; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008545:Melanoma / Q000235:genetics; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012878:Skin Neoplasms / Q000235:genetics
chemical_list: D004273:DNA, Neoplasm