title: The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study.
abstract: BACKGROUND
  Cytomegalovirus (CMV) causes congenital infection with high mortality and morbidity rates in affected neonates.
  
  
  OBJECTIVE
  To evaluate the maternal IgG avidity value for the prediction of congenital CMV infection.
  
  
  METHODS
  The serum IgG avidity in all mothers was measured, and the urine of their neonates was assessed for CMV DNA in a prospective cohort study.
  
  
  RESULTS
  Of 759 women with a positive test for CMV IgG, 14 had congenital CMV infection. CMV IgG avidity indices in the congenital infection group (median 35.1%) were significantly lower than those in the non-congenital infection group (70.4%). A cutoff value of <40% IgG avidity index with 96.1% specificity and 64.3% sensitivity for congenital infection was determined by receiver operating characteristic curve analyses. The highest sensitivity (88.9%), 96.2% specificity, 27.6% positive predictive value, 99.8% negative predictive value, and 96.1% accuracy were found when IgG avidity was measured in <28 weeks of gestation.
  
  
  CONCLUSIONS
  The IgG avidity measurement with a cutoff value of <40% IgG avidity index might be helpful in predicting congenital CMV infection, especially in <28 weeks of gestation.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Ebina
authors.forename: Toshio
authors.initials: T
authors.lastname: Minematsu
authors.forename: Ayako
authors.initials: A
authors.lastname: Sonoyama
authors.forename: Ichiro
authors.initials: I
authors.lastname: Morioka
authors.forename: Naoki
authors.initials: N
authors.lastname: Inoue
authors.forename: Shinya
authors.initials: S
authors.lastname: Tairaku
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nagamata
authors.forename: Kenji
authors.initials: K
authors.lastname: Tanimura
authors.forename: Mayumi
authors.initials: M
authors.lastname: Morizane
authors.forename: Masashi
authors.initials: M
authors.lastname: Deguchi
authors.forename: Hideto
authors.initials: H
authors.lastname: Yamada
mesh_terms: D000915:Antibody Affinity; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015331:Cohort Studies; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000175:diagnosis / Q000276:immunology / Q000635:transmission; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G