title: Harnessing FOXP3+ regulatory T cells for transplantation tolerance.
abstract: Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression.
authors.forename: Herman
authors.initials: H
authors.lastname: Waldmann
authors.forename: Robert
authors.initials: R
authors.lastname: Hilbrands
authors.forename: Duncan
authors.initials: D
authors.lastname: Howie
authors.forename: Stephen
authors.initials: S
authors.lastname: Cobbold
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism / Q000637:transplantation; D023001:Transplantation Tolerance
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D011948:Receptors, Antigen, T-Cell