title: A new and efficient method for the synthesis of Ulipristal acetate.
abstract: In this study, we describe another new and efficient route for preparing Ulipristal acetate. The 1,4-addition compound 5 was greatly improved after the starting material ketone 1 was underwent epoxidation, cyanation, hydroxyl group protection and Grignard addition. The synthetic procedure is only 6 steps and the total yield is about 27.4%, which is much suitable for industrial process.
authors.affiliation: Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
authors.forename: Xu
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
authors.forename: Xiaocen
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Duan
authors.affiliation: Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
authors.forename: Yongguo
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China. Electronic address: smile@scu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Hai
authors.affiliation: Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China. Electronic address: wyong@scu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
mesh_terms: D009649:Norpregnadienes / Q000138:chemical synthesis*; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D009649:Norpregnadienes; C555622:ulipristal acetate
keywords: Diastereoisomers; Industrial process; Synthesis; Ulipristal acetate