title: Breaking the mould - novel diagnostic and therapeutic strategies for invasive pulmonary aspergillosis in the immune deficient patient.
abstract: Invasive pulmonary aspergillosis (IPA) caused by the ubiquitous environmental fungus Aspergillus is a frequently fatal lung disease of immunocompromised humans accounting for more than 200,000 infections each year, with an associated mortality rate of 30-90%. This review addresses the current status of IPA diagnosis and treatment and the urgent need to develop accurate, non-invasive strategies for identifying pulmonary infections in the ever-expanding population of immune deficient patients at risk of acquiring opportunistic fungal infections including hematological malignancy and hematopoetic stem cell transplant patients. Recent advances in the use of an Aspergillus-specific monoclonal antibody, JF5, for point-of-care diagnosis of IPA using lateral-flow technology is examined, as is its use in PET/MRI bioimaging and radio-immunotherapy using radionuclide-labeled single chain antibody fragments, Fab fragments, and a fully humanized JF5 derivative.
authors.affiliation: Biosciences, University of Exeter, Geoffrey Pope Building, Exeter, EX4 4QD, UK.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Thornton
mesh_terms: D000818:Animals; D000908:Antibodies, Fungal / Q000276:immunology / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000276:immunology / Q000627:therapeutic use; D001230:Aspergillus / Q000276:immunology*; D017074:Common Variable Immunodeficiency; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology / Q000627:therapeutic use; D049268:Positron-Emission Tomography; D055732:Pulmonary Aspergillosis / Q000000981:diagnostic imaging / Q000276:immunology / Q000628:therapy; D011859:Radiography
chemical_list: D000908:Antibodies, Fungal; D061067:Antibodies, Monoclonal, Humanized; D007140:Immunoglobulin Fab Fragments
keywords: PET/MRI; bioimaging; hematological malignancy; invasive pulmonary aspergillosis; monoclonal antibody; radioimmunotherapy; stem cell transplant; vaccine