title: Superficial radially resolved fluorescence and 3D photochemical time-dependent model for photodynamic therapy.
abstract: Photodynamic therapy (PDT) dosimetric tools are crucial for treatment planning and noninvasive monitoring by means of fluorescence. Present approaches consider usually a 1D problem, a simple photochemical process, or a spatially homogeneous photosensitizer. In this work, a radially resolved superficial photosensitizer fluorescence and 3D photochemical time-dependent PDT model are presented. The model provides a time-dependent estimation of tissue fluorescence and the photosensitizer and singlet oxygen 3D concentrations. The model is applied to a basal cell carcinoma treated by Metvix topical photosensitizer protocol. The analysis shows the potentiality in treatment planning and monitoring. The fluorescence results are in agreement with previous measurements.
authors.forename: Irene
authors.initials: I
authors.lastname: Salas-García
authors.forename: Félix
authors.initials: F
authors.lastname: Fanjul-Vélez
authors.forename: José Luis
authors.initials: JL
authors.lastname: Arce-Diego
mesh_terms: D002280:Basal Cell Carcinoma / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D055668:Photochemical Processes; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use; D011524:Protoporphyrins / Q000737:chemistry / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology; D013050:Spectrometry, Fluorescence; D013997:Time Factors
chemical_list: D017319:Photosensitizing Agents; D011524:Protoporphyrins; C028025:protoporphyrin IX