title: Palladium-catalyzed stereoselective intramolecular oxidative amidation of alkenes in the synthesis of 1,3- and 1,4-amino alcohols and 1,3-diamines.
abstract: An efficient and practical Pd-catalyzed intramolecular oxidative allylic amidation provides facile access to derivatives of 1,3- and 1,4-amino alcohols and 1,3-diamines. The method operates under mild reaction conditions (RT) with molecular oxygen (1 atm) as the sole reoxidant of Pd. Excellent diastereoselectivities were attained with substrates bearing a secondary stereogenic center.
authors.affiliation: Department of Chemistry, Loughborough University, Loughborough, LE11 3TU (UK), Fax: (+44) 1509-22-3925. A.Malkov@lboro.ac.uk.
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Malkov
authors.forename: Darren S
authors.initials: DS
authors.lastname: Lee
authors.forename: Maciej
authors.initials: M
authors.lastname: Barłóg
authors.forename: Mark R J
authors.initials: MR
authors.lastname: Elsegood
authors.forename: Pavel
authors.initials: P
authors.lastname: Kočovský
keywords: allylic compounds; amination; cyclization; homogeneous catalysis; palladium