title: Cytotoxic effects of four aescin types on human colon adenocarcinoma cell lines.
abstract: Four types of aescin that are available on the pharmaceutical market, beta-aescin crystalline, beta-aescin amorphous, beta-aescin sodium and aescin polysulfate, have been analyzed for their cytotoxic effects on human colon adenocarcinoma (LoVo) and doxorubicin-resistant human colon adenocarcinoma cell lines (LoVo/Dx). Their cytotoxic activities were evaluated by sulforhodamine B (SRB) and methyl tetrazolium (MTT) assays. All four types of aescin exerted strong dose-dependent cytotoxicity to LoVo and, to a lesser degree, LoVo/Dx cell lines. The IC50 value for the LoVo/Dx cell line was higher, but still dose-dependent. Results from both assays demonstrated that p-aescin crystalline has the most cytotoxic activity toward human colon adenocarcinoma cell lines.
authors.forename: Ewa
authors.initials: E
authors.lastname: Seweryn
authors.forename: Michal
authors.initials: M
authors.lastname: Gleńsk
authors.forename: Kamila
authors.initials: K
authors.lastname: Sroda-Pomianek
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Ceremuga
authors.forename: Maciej
authors.initials: M
authors.lastname: Wlodarczyk
authors.forename: Andrzej
authors.initials: A
authors.lastname: Gamian
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D031319:Aesculus; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004317:Doxorubicin; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D004928:Escin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004928:Escin; D004317:Doxorubicin