title: Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network.
abstract: An open-source implementation of a previously published integrated testing strategy (ITS) for skin sensitization using a Bayesian network has been developed using R, a free and open-source statistical computing language. The ITS model provides probabilistic predictions of skin sensitization potency based on in silico and in vitro information as well as skin penetration characteristics from a published bioavailability model (Kasting et al., 2008). The structure of the Bayesian network was designed to be consistent with the adverse outcome pathway published by the OECD (Jaworska et al., 2011, 2013). In this paper, the previously published data set (Jaworska et al., 2013) is improved by two data corrections and a modified application of the Kasting model. The new data set implemented in the original commercial software package and the new R version produced consistent results. The data and a fully documented version of the code are publicly available (http://ntp.niehs.nih.gov/go/its).
authors.affiliation: Social and Scientific Systems, Inc., Durham, NC, USA.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Pirone
authors.forename: Marjolein
authors.initials: M
authors.lastname: Smith
authors.forename: Nicole C
authors.initials: NC
authors.lastname: Kleinstreuer
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Burns
authors.forename: Judy
authors.initials: J
authors.lastname: Strickland
authors.forename: Yuri
authors.initials: Y
authors.lastname: Dancik
authors.forename: Richard
authors.initials: R
authors.lastname: Morris
authors.forename: Lori A
authors.initials: LA
authors.lastname: Rinckel
authors.forename: Warren
authors.initials: W
authors.lastname: Casey
authors.forename: Joanna S
authors.initials: JS
authors.lastname: Jaworska
mesh_terms: D000826:Animal Testing Alternatives; D000818:Animals; D001499:Bayes Theorem; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D003877:Dermatitis, Contact; D066298:In Vitro Techniques; D010067:Ownership; D012882:Skin Tests; D012984:Software; D018675:Toxicity Tests / Q000379:methods*