title: Bioactive magnetic nanoparticles of Fe-Ga synthesized by sol-gel for their potential use in hyperthermia treatment.
abstract: Hyperthermia is one of the most recents therapies for cancer treatment using particles with nanometric size and appropriate magnetic properties for destroying cancer cells. Magnetic nanoparticles (MNP's) of Fe-Ga and synthesized using a polycondensation reaction by sol-gel method were obtained. MNP's of Fe(1.4)Ga(1.6)O(4) that possess an inverse spinel structure were identified by X-Ray Diffraction, Transmission Electron Microscopy, Scanning Electron Microscopy and Energy Dispersive Spectroscopy. The results showed that the MNP's are composed only by Fe, Ga and O and their size is between 15 and 20 nm. The magnetic properties measured by Vibration Sample Magnetometry demonstrated a saturation magnetization value of 37.5 emu/g. To induce the MNP's bioactivity, a biomimetic method was used which consisted in the immersion of MNP's in a Simulated Body Fluid (SBF) for different periods of time (7, 14 and 21 d) along with a wollastonite disk. The formation of a bioactive layer, which closely resembles that formed on the existing bioactive systems and with a Ca/P atomic ratio within a range of 1.37-1.73 was observed on the MNP's. Cytotoxicity of MNP's was evaluated by in vitro hemolysis testing using human red blood cells at concentrations between 0.25 and 6.0 mg/mL. It was found that the MNP's were not cytotoxic at none of the concentrations used. The results indicate that Fe-Ga MNP's are potential materials for cancer treatment of both hard and soft tissue by hyperthermia and drug carriers, among other applications.
authors.affiliation: Cinvestav-Unidad Saltillo, Ave. Industria Metalúrgica No. 1062, Parque Industrial Saltillo-Ramos Arizpe, CP 25900, Ramos Arizpe, Coah, México, h_javiersanchez@hotmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Sánchez
authors.forename: D A
authors.initials: DA
authors.lastname: Cortés-Hernández
authors.forename: J C
authors.initials: JC
authors.lastname: Escobedo-Bocardo
authors.forename: R A
authors.initials: RA
authors.lastname: Jasso-Terán
authors.forename: A
authors.initials: A
authors.lastname: Zugasti-Cruz
mesh_terms: D001672:Biocompatible Materials / Q000009:adverse effects / Q000138:chemical synthesis / Q000737:chemistry; D004912:Erythrocytes / Q000187:drug effects; D005290:Ferric Compounds / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry*; D005708:Gallium / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods; D058185:Magnetite Nanoparticles / Q000009:adverse effects / Q000737:chemistry; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology / Q000379:methods; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D005708:Gallium