title: A meta-analysis of association of vitamin D receptor BsmI gene polymorphism with the risk of type 1 diabetes mellitus.
abstract: Association between vitamin D receptor (VDR) BsmI (rs1544410) gene polymorphism and the risk of type 1 diabetes mellitus (T1DM) from the published reports are still conflicting. This study was conducted to evaluate the relationship between VDR BsmI gene polymorphism and the risk of T1DM using meta-analysis method. The association studies were identified from PubMed, and Cochrane Library on 1 December 2013, and eligible investigations were included and synthesized using meta-analysis method. Twenty-three reports were recruited into this meta-analysis for the association of VDR BsmI gene polymorphism with T1DM susceptibility. In overall populations, bb genotype was associated with T1DM, but the B allele and BB genotype were not. In Asians and Latino population, B allele and bb genotype were associated with TIDM risk, but BB genotype was not. In Caucasians, VDR BsmI gene polymorphism was not associated with the T1DM risk. In Africans, B allele and BB genotype were associated with T1DM risk, but the bb genotype was not. However, the sample size for Latino population and Africans was small. In conclusion, VDR BsmI B allele, bb genotype was associated with T1DM risk in Asians, and bb genotype was associated with T1DM risk in overall populations. However, more studies should be conducted to confirm it.
authors.affiliation: Department of Endocrinology, People's Hospital of Beihai , Beihai , China.
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Qin
authors.forename: Han-Xiao
authors.initials: HX
authors.lastname: Wang
authors.forename: Jun-Lin
authors.initials: JL
authors.lastname: Qiu
authors.forename: Xue-Bin
authors.initials: XB
authors.lastname: Huang
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Nian-Rong
authors.initials: NR
authors.lastname: Wu
authors.forename: Hua-Sheng
authors.initials: HS
authors.lastname: Liang
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000208:ethnology* / Q000235:genetics*; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology* / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D044469:Racial Groups / Q000706:statistics & numerical data*; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D018167:Receptors, Calcitriol
keywords: Gene polymorphism; Type 1 diabetes mellitus; meta-analysis; vitamin D receptor