title: Co-occurrence of monoclonal gammopathy and myelodysplasia: a retrospective study of fourteen cases.
abstract: We report a series of 14 patients with myelodysplastic syndrome (MDS) accompanied by a monoclonal gammopathy unrelated to therapy. Twelve of these had monoclonal gammopathy of undermined significance (MGUS) and two had smoldering multiple myeloma. These cases represent 10.2 % of all MDS cases seen at our institution over a 14-year period (January 2000 to December 2013). The incidence of MGUS was determined to be significantly higher in MDS than in age-matched concurrent controls by χ(2) test. Absence of prior chemotherapy and simultaneous presentation of MDS and MGUS in most cases suggest true co-occurrence of the two disorders. MGUS was found in all WHO subtypes of MDS with a wide range of risk factors. However, 11 out of the 12 MDS cases accompanied with MGUS had relatively low karyotypic risks. In addition, serum M protein levels remained largely unchanged in 4 cases of MGUS for which serial determinations were performed. These findings indicate that MGUS may not affect the prognosis of MDS.
authors.affiliation: The Center for Hematological Diseases, Takeda General Hospital, Fushimi, Kyoto, 601-1495, Japan, yoshida@takedahp.or.jp.
authors.forename: Yataro
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Shigeru
authors.initials: S
authors.lastname: Oguma
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohno
authors.forename: Yukiharu
authors.initials: Y
authors.lastname: Nakabo
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Katsurada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kawahara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawabata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D010265:Paraproteinemias / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D010641:Phenotype; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult