title: Controlled-release systems for metal-based nanomedicine: encapsulated/self-assembled nanoparticles of anticancer gold(III)/platinum(II) complexes and antimicrobial silver nanoparticles.
abstract: The therapeutic applications of many anticancer or antimicrobial metal complexes often suffer from low solubility and low stability in physiological conditions or from drug resistance. To circumvent these problems, nanoparticle systems that allow controlled release and specific accumulation in the targeted disease tissue are of advantage for efficient treatment with minimal toxicity. The focus of this Research News is metal-based nanomaterials comprising anticancer gold(III)/platinum(II) complexes or antimicrobial silver, highlighting the controlled-release properties of self-assembled metal systems.
authors.affiliation: State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong.
authors.forename: Chun-Nam
authors.initials: CN
authors.lastname: Lok
authors.forename: Taotao
authors.initials: T
authors.lastname: Zou
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Iris Wing-Shan
authors.initials: IW
authors.lastname: Lin
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry; D017612:Gold Compounds / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D050997:Nanomedicine / Q000295:instrumentation / Q000379:methods*; D017671:Platinum Compounds / Q000008:administration & dosage / Q000737:chemistry; D018030:Silver Compounds / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D017612:Gold Compounds; D017671:Platinum Compounds; D018030:Silver Compounds
keywords: anticancer; antimicrobial materials; gold/platinum/silver; nanoparticles