title: Luteolin protects against high fat diet-induced cognitive deficits in obesity mice.
abstract: The epidemic and experimental studies have confirmed that the obesity can lead to neuroinflammation, neurodegenerative diseases and adversely affect cognition. Despite the numerous elucidations on the impact of obesity on cognition decline, the contributors to the impairments in obesity remain unclear. Male C57BL/6J mice were fed either a control or high-fat diet (HFD) for 16 weeks and then randomized into four groups treated with their respective diets for 4 weeks including control diet (CD); control diet+luteolin (CDL); high-fat diet (HFD), high-fat diet+luteolin (HFDL). The dose of luteolin was 10mg/kg, oral. We showed that adding luteolin in high-fat diet can significantly reduce body weight gain, food intake and plasma cytokines as well as improving glucose metabolism of mice on HFD. Importantly, we showed that luteolin treatment had the effects of alleviating neuroinflammation, oxidative stress and neuronal insulin resistance in the mouse brain, restored blood adipocytokines level to normal. Furthermore, luteolin increased the level of brain-derived neurotrophic factor (BDNF), the action of synapsin I (SYP) and postsynaptic density protein 95 (PSD-95) in the cortex and hippocampus as to that the behavioral performance in Morris water maze (MWM) and step-through task were significantly improved. These results indicate a previously unrecognized potential of luteolin in alleviating obesity-induced cognitive impairment for type-2 diabetes mellitus and Alzheimer disease (AD).
authors.affiliation: Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: cbpe201087@gmail.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: cbpe201104@163.com.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Fu
authors.affiliation: Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: xinjingwutong@163.com.
authors.forename: Nuo
authors.initials: N
authors.lastname: Lan
authors.affiliation: Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: lisai0821@sina.com.
authors.forename: Sai
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: zjingzlove@163.com.
authors.forename: Jingzheng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: wszc0220@126.com.
authors.forename: Shuaishuai
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: lc510520@126.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: dashanlidenanhaiwo@163.com.
authors.forename: Yanguo
authors.initials: Y
authors.lastname: Shang
authors.affiliation: Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: tonghhuang@gmail.com.
authors.forename: Tonghui
authors.initials: T
authors.lastname: Huang
authors.affiliation: Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
mesh_terms: D054392:Adipokines / Q000097:blood; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D016207:Cytokines / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects*; D000076122:Disks Large Homolog 4 Protein; D004435:Eating / Q000187:drug effects; D051528:Guanylate Kinases / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D047311:Luteolin / Q000493:pharmacokinetics*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D008810:Mice, Inbred C57BL; D015213:Neuroimmunomodulation / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D009765:Obesity / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D016704:Synapsins / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
chemical_list: D054392:Adipokines; D019440:Anti-Obesity Agents; D001786:Blood Glucose; D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D000076122:Disks Large Homolog 4 Protein; C501447:Dlg4 protein, mouse; D008565:Membrane Proteins; D016704:Synapsins; D051528:Guanylate Kinases; D047311:Luteolin
keywords: C57BL/6J mice; High-fat diet; Luteolin; Neuronal insulin resistance; Obesity; Synaptic plasticity