title: Management of localized esophageal cancer in the older patient.
abstract: Most patients with gastroesophageal cancers are older than 65 years of age. The management of older patients poses challenges because they have multiple comorbidities and physiological changes associated with aging. Furthermore, data are limited on tolerance of cancer therapy and the use of combined-modality treatments in this patient population to guide their treatment. In this article, we focus on the management of older patients with localized esophageal cancer, highlighting the role of comprehensive geriatric assessment to identify and better tailor treatment approaches in this patient population. We review the literature and discuss the role of surgical resection and potential complications specific to an older patient. We review the rationale of combined-modality treatment and the potential benefits of a chemoradiotherapy-based approach in this patient population.
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Won
authors.forename: David H
authors.initials: DH
authors.lastname: Ilson
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D001918:Brachytherapy; D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D015897:Comorbidity; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D015577:Geriatric Assessment; D006801:Humans; D008875:Middle Aged; D016879:Salvage Therapy
keywords: Chemoradiotherapy; Elderly; Esophageal cancer; Geriatric oncology