title: Serum uric acid is associated with arterial stiffness in men with newly diagnosed type 2 diabetes mellitus.
abstract: BACKGROUND
  Increased serum uric acid levels and vascular atherosclerosis are very common in diabetes. However, few studies focused on the relationship between serum uric acid and aortic or peripheral arterial stiffness in newly diagnosed diabetic patients. This study investigated the association between serum uric acid levels and carotid-femoral pulse wave velocity (cfPWV) or carotid-radial (cr) PWV in male patients with newly diagnosed type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  106 male patients with newly diagnosed T2DM were recruited. cfPWV and crPWV as well as anthropometric parameters, blood pressure, serum uric acid, blood glucose, fasting insulin, C-reactive protein and blood lipids were measured.
  
  
  RESULTS
  The subjects were divided into low uric acid (UA) subgroup and high UA subgroup according to uric acid median. cfPWV and crPWV were significantly higher in high UA subgroup. Serum uric acid significantly correlated with cfPWV (r = 0.533, P < 0.001), crPWV (r = 0.334, P = 0.001), waist circumference (r = 0.350, P < 0.001), waist-to-hip ratio (r = 0.254, P = 0.009), fasting insulin (r = 0.432, P < 0.001), HOMA-IR (r = 0.173, P = 0.042), fasting blood glucose (r = -0.271, P = 0.005), haemoglobin A1c (r = -0.202, P = 0.038), and HDL-cholesterol (r = -0.267, P = 0.006) after correction for age. Stepwise multiple regressions showed that the independent determinants of cfPWV were serum uric acid, age, C-reactive protein, HDL-cholesterol, and smoking status. And the independent determinants of crPWV were serum uric acid, age, diastolic blood pressure, and HDL-cholesterol.
  
  
  CONCLUSIONS
  Serum uric acid is significantly associated with increased aortic and peripheral arterial stiffness in men with T2DM at the early stage.
authors.affiliation: Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuluo Road 627, Wuhan, 430070, Hubei, People's Republic of China, zhangjx666@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Xiang
authors.forename: L
authors.initials: L
authors.lastname: Xiang
authors.forename: H
authors.initials: H
authors.lastname: Sun
mesh_terms: D000328:Adult; D000367:Age Factors; D050197:Atherosclerosis / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D002097:C-Reactive Protein / Q000032:analysis; D002339:Carotid Arteries / Q000503:physiopathology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D042241:Early Diagnosis; D005263:Femoral Artery / Q000503:physiopathology; D006801:Humans; D033461:Hyperuricemia / Q000150:complications* / Q000175:diagnosis; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D017534:Radial Artery / Q000503:physiopathology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014527:Uric Acid / Q000097:blood*; D059289:Vascular Stiffness
chemical_list: D014527:Uric Acid; D002097:C-Reactive Protein