title: Value of coronary artery calcium score to predict severity or complexity of coronary artery disease.
abstract: BACKGROUND
  Prediction of severity or complexity of coronary artery disease (CAD) is valuable owing to increased risk for cardiovascular events. Although the association between total coronary artery calcium (CAC) score and severity of CAD, Gensini score was not used, it has been previously demonstrated. There is no information about the association between total CAC score and complexity of CAD.
  
  
  OBJECTIVE
  To investigate the association between severity or complexity of coronary artery disease (CAD) assessed by Gensini score and SYNTAX score (SS), respectively, and coronary artery calcium (CAC) score, which is a noninvasive method for CAD evaluation in symptomatic patients with accompanying significant CAD.
  
  
  METHODS
  Two-hundred-fourteen patients were enrolled. Total CAC score was obtained before angiography. Severity and complexity of CAD was assessed by Gensini score and SS, respectively. Associations between clinical and angiographic parameters and total CAC score were analyzed.
  
  
  RESULTS
  Median total CAC score was 192 (23.0-729.8), and this was positively correlated with both Gensini score (r: 0.299, p<0.001) and SS (r: 0.577, p<0.001). At multivariate analysis, it was independently associated with age (ß: 0.154, p: 0.027), male gender (ß: 0.126, p: 0.035) and SS (ß: 0.481, p<0.001). Receiver-operating characteristic (ROC) curve analysis revealed a cut-off value>809 for SS>32 (high SS tertile).
  
  
  CONCLUSIONS
  In symptomatic patients with accompanying significant CAD, total CAC score was independently associated with SS and patients with SS>32 may be detected through high Agatston score.
authors.affiliation: Departamento de Cardiologia, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital.
authors.forename: Tayyar
authors.initials: T
authors.lastname: Gökdeniz
authors.affiliation: Departamento de Cardiologia, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital.
authors.forename: Ezgi
authors.initials: E
authors.lastname: Kalaycıoğlu
authors.affiliation: Departamento de Cardiologia, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital.
authors.forename: Ahmet Çağrı
authors.initials: AÇ
authors.lastname: Aykan
authors.affiliation: Departamento de Cardiologia, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital.
authors.forename: Faruk
authors.initials: F
authors.lastname: Boyacı
authors.affiliation: Departamento de Cardiologia, Akcabat State Hospital, Trabzon, Turquia.
authors.forename: Turhan
authors.initials: T
authors.lastname: Turan
authors.affiliation: Departamento de Cardiologia, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital.
authors.forename: İlker
authors.initials: İ
authors.lastname: Gül
authors.affiliation: Departamento de Radiologia, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Çavuşoğlu
authors.affiliation: Departamento de Cardiologia, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital.
authors.forename: İhsan
authors.initials: İ
authors.lastname: Dursun
mesh_terms: D000367:Age Factors; D000368:Aged; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000175:diagnosis*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012737:Sex Factors; D061205:Vascular Calcification / Q000175:diagnosis*