title: A model of articular cruciate ligament reconstructive surgery: a validation construct and computational insights.
abstract: This study sought to develop a computational framework that emulates the articular cruciate ligament reconstruction surgery using transtibial portal technique. The proposed model included the tibia-femoral and patella-femoral joints, articular cartilage and menisci. Key surgical parameters were incorporated including bone-patellar-tendon-bone graft excision and pre-tensioning, tunnel morphology, bone plugs, and bone plug fixation. Several simulation steps were parameterized to reflect the clinically reported surgical procedure. Our focus was to explore the intra-operative effects of variations in tunnel directions on the selected metrics of joint mechanics during Lachman and Anterior Drawer tests. A mathematical construct capable of transforming the limited and heterogeneous experimental and surgical data to evidence-based validation was adopted to ensure the viability of the finite element models. We found that the proposed models, subject to a variation in tunnel directions, resulted in simulation outputs that favor the reported experimental data of Lachman and Anterior Drawer tests under uncertainty. Simulation results for a population of three-dimensional tunnel orientations provided insights into the graft-tunnel contact mechanics and the spatial stress distribution in the graft, insights that have been anecdotally observed in prior experimental studies. The intraarticular graft tension was found to be higher than the estimated in tunnel graft force, and larger differences were found for the least inclined tunnels exhibiting higher contact pressures, transverse bending and twisting of the graft and Von-Mises stress at the graft-femoral tunnel interface. Conversely, tunnels with high inclination angles exhibited higher intraarticular graft tension and Von-Mises stress at the graft-tibial bone plug interface.
authors.affiliation: Northwestern University, Physical Medicine and Rehabilitation Department, 345 East Superior Street, Chicago, IL 60611, USA; Rehabilitation Institute of Chicago, Sensory Motor Performance Program, 345 East Superior Street, Chicago, IL 60611, USA. Electronic address: salehghaffari@gmail.com.
authors.forename: Shahab
authors.initials: S
authors.lastname: Salehghaffari
authors.affiliation: Northwestern University, Physical Medicine and Rehabilitation Department, 345 East Superior Street, Chicago, IL 60611, USA; Rehabilitation Institute of Chicago, Sensory Motor Performance Program, 345 East Superior Street, Chicago, IL 60611, USA; Northwestern University, Biomedical Engineering Department, 2145 Sheridan Road, Evanston, IL 60208, USA.
authors.forename: Yasin Y
authors.initials: YY
authors.lastname: Dhaher
mesh_terms: D059549:Anterior Cruciate Ligament Reconstruction; D005269:Femur / Q000502:physiology; D020342:Finite Element Analysis; D006801:Humans; D007596:Joints / Q000502:physiology / Q000601:surgery; D008592:Menisci, Tibial / Q000502:physiology / Q000601:surgery; D008954:Models, Biological; D010329:Patella / Q000502:physiology; D013977:Tibia / Q000502:physiology; D035501:Uncertainty
keywords: Articular cartilage osteoarthritis; Experimental errors; Finite element model; Surgical variability; Tunnel direction; Validation under epistemic uncertainty