title: pH-Responsive and near-infrared-emissive polymer nanoparticles for simultaneous delivery, release, and fluorescence tracking of doxorubicin in vivo.
abstract: Dextran modified with pendant acetals is used to load doxorubicin (DOX) and a near-infrared-emissive conjugated polymer (BTTPF), and this aims to provide selective drug release at therapeutic targets including tumors. The BTTPF is applicable to tracking the anticancer drug release through the change of Förster resonance energy transfer efficiency between doxorubicin and BTTPF during degradation of the nanoparticles in vivo.
authors.affiliation: Department of Polymer Science & Engineering, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210093, China. qdshen@nju.edu.cn.
authors.forename: Ji-Cheng
authors.initials: JC
authors.lastname: Yu
authors.forename: Yu-Lei
authors.initials: YL
authors.lastname: Chen
authors.forename: Yu-Qi
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Xi-Kuang
authors.initials: XK
authors.lastname: Yao
authors.forename: Cheng-Gen
authors.initials: CG
authors.lastname: Qian
authors.forename: Jun
authors.initials: J
authors.lastname: Huang
authors.forename: Sha
authors.initials: S
authors.lastname: Zhu
authors.forename: Xi-Qun
authors.initials: XQ
authors.lastname: Jiang
authors.forename: Qun-Dong
authors.initials: QD
authors.lastname: Shen
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
mesh_terms: D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods*; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism; D011108:Polymers / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D023041:Xenograft Model Antitumor Assays / Q000379:methods
chemical_list: D005456:Fluorescent Dyes; D011108:Polymers; D004317:Doxorubicin