title: Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosis.
abstract: BACKGROUND
  The pathogenesis of glioma is unclear. The disturbance of the apoptosis process plays a critical role in glioma growth. Factors regulating the apoptosis process are to be further understood. This study aims to investigate the role of protease activated receptor-2 (PAR2) in regulation the apoptosis process in glioma cells.
  
  
  RESULTS
  The results showed that U87 cells and human glioma tissue expressed PAR2. Exposure to tryptase, or the PAR2 active peptide, increased STAT3 phosphorylation in the radiated U87 cells, reduced U87 cell apoptosis, suppressed the expression of p53 in U87 cells.
  
  
  CONCLUSIONS
  Activation of PAR2 can reduce the radiated U87 cell apoptosis via modulating the expression of p53. The results implicate that PAR2 may be a novel therapeutic target in the treatment of glioma.
authors.forename: Ran
authors.initials: R
authors.lastname: Luo
authors.affiliation: Department of Neurosurgery, Institute of Neurosurgery, Yichang Central People's Hospital & The First Clinical Medical College of Three Gorges University, Yichang, Hubei 443003, P,R, China. xiongweiwang4@163.com.
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Wang
authors.forename: Yuanxun
authors.initials: Y
authors.lastname: Dong
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Chunlei
authors.initials: C
authors.lastname: Tian
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D045744:Cell Line, Tumor; D004789:Enzyme Activation / Q000235:genetics; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D058990:Molecular Targeted Therapy; D044464:Receptor, PAR-2 / Q000096:biosynthesis* / Q000235:genetics; D050796:STAT3 Transcription Factor / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
chemical_list: D044464:Receptor, PAR-2; D050796:STAT3 Transcription Factor; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53