title: Total synthesis of the putative structure of xylarinol B.
abstract: The total synthesis of the putative structure of xylarinol B is described and the need to revise its structure is demonstrated. The central benzoxepine skeleton was constructed by employing a cobalt-mediated bimolecular [2+2+2] Reppe-Vollhardt alkyne cycloaddition reaction.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune - 411 008 (India), Fax: (+91) 20-25902629.
authors.forename: Atul A
authors.initials: AA
authors.lastname: More
authors.forename: Chepuri V
authors.initials: CV
authors.lastname: Ramana
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001584:Benzoxepins / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry; D003500:Cyclization; D061565:Cycloaddition Reaction; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry; D013098:Xylariales / Q000737:chemistry
chemical_list: D000480:Alkynes; D001584:Benzoxepins; C544246:xylarinol A; D003035:Cobalt; D012238:Rhodium
keywords: chiral pool; cobalt; natural products; structure elucidation; total synthesis