title: Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing.
abstract: Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of "epidermal" electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management.
authors.affiliation: Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hattori
authors.forename: Leo
authors.initials: L
authors.lastname: Falgout
authors.forename: Woosik
authors.initials: W
authors.lastname: Lee
authors.forename: Sung-Young
authors.initials: SY
authors.lastname: Jung
authors.forename: Emily
authors.initials: E
authors.lastname: Poon
authors.forename: Jung Woo
authors.initials: JW
authors.lastname: Lee
authors.forename: Ilyoun
authors.initials: I
authors.lastname: Na
authors.forename: Amelia
authors.initials: A
authors.lastname: Geisler
authors.forename: Divya
authors.initials: D
authors.lastname: Sadhwani
authors.forename: Yihui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yewang
authors.initials: Y
authors.lastname: Su
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Wang
authors.forename: Zhuangjian
authors.initials: Z
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Xia
authors.forename: Huanyu
authors.initials: H
authors.lastname: Cheng
authors.forename: R Chad
authors.initials: RC
authors.lastname: Webb
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Bonifas
authors.forename: Philip
authors.initials: P
authors.lastname: Won
authors.forename: Jae-Woong
authors.initials: JW
authors.lastname: Jeong
authors.forename: Kyung-In
authors.initials: KI
authors.lastname: Jang
authors.forename: Young Min
authors.initials: YM
authors.lastname: Song
authors.forename: Beatrice
authors.initials: B
authors.lastname: Nardone
authors.forename: Michael
authors.initials: M
authors.lastname: Nodzenski
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Fan
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Huang
authors.forename: Dennis P
authors.initials: DP
authors.lastname: West
authors.forename: Amy S
authors.initials: AS
authors.lastname: Paller
authors.forename: Murad
authors.initials: M
authors.lastname: Alam
authors.forename: Woon-Hong
authors.initials: WH
authors.lastname: Yeo
authors.forename: John A
authors.initials: JA
authors.lastname: Rogers
mesh_terms: D000368:Aged; D004582:Electronics, Medical / Q000295:instrumentation*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D012828:Silicones; D012881:Skin Temperature / Q000502:physiology; D053832:Surgical Tape; D013817:Thermography / Q000295:instrumentation; D014945:Wound Healing / Q000502:physiology*
chemical_list: D012828:Silicones
keywords: clinical study; epidermal electronics; multifunctional; skin-like; wound monitoring