title: Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208.
abstract: Axinelline A, a new cyclooxygenase-2 (COX-2) inhibitor, was isolated from Streptomyces axinellae SCSIO02208. The structures of compounds 1-9 were determined by analysing the NMR and MS data. The absolute configuration of 1 was determined by using optical rotation and comparing with the reported data. Compound 1 exhibited COX-2 inhibitory activity, the IC50 value being 2.8 μM.
authors.affiliation: a Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Ai
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Lin
authors.forename: Zhengchao
authors.initials: Z
authors.lastname: Tu
authors.forename: Xin-Peng
authors.initials: XP
authors.lastname: Tian
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.forename: Fredimoses
authors.initials: F
authors.lastname: Mangaladoss
authors.forename: Zhi-Long
authors.initials: ZL
authors.lastname: Zhong
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D002396:Catechols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D002396:Catechols; D052246:Cyclooxygenase 2 Inhibitors; C000593051:axinelline A; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human
keywords: COX-2; Streptomyces axinellae; inhibitor