title: Impact of Vitamin E Supplementation on Blood Pressure and Hs-CRP in Type 2 Diabetic Patients | doi: 10.5681/hpp.2012.009.
abstract: BACKGROUND
  Type 2 diabetes mellitus (T2DM) is a major public health problem worldwide. Hypertension and inflammation are well recognized as risk factors for the macrovascular complications of diabetes. The aim of this study was to assess the impact of vitamin E supplementation on blood pressure (BP), serum high-sensitivity C-reactive protein (hs-CRP) and fasting blood glucose in patients with T2DM.
  
  
  METHODS
  In a double blind, randomized, controlled clinical trial, 83 patients with T2DM were divided randomly into two groups of vitamin E (400 mg/d, n=42) and placebo (n=41). All patients received the pearls for 8 weeks. Baseline and eighth week BP, serum hs-CRP, fasting blood glucose, anthropometric and dietary intake data were obtained from each patient. Data were analyzed using SPSS version 11.5. &nbsp;
  
  
  RESULTS
  Vitamin E supplementation significantly increased serum levels of vitamin E (P &lt; 0.001) and decreased mean arterial pressure and fasting blood glucose (P = 0.047, P = 0.028, respectively) in vitamin E group as compared with placebo group. A significant decrease in systolic blood pressure and diastolic blood pressure was observed in the vitamin E group comparing with baseline values (all P &lt; 0.01). There were no significant changes in serum hs-CRP in both of the studied groups.
  
  
  CONCLUSIONS
  Vitamin E had beneficial effects on serum vitamin E, BP and blood glucose in patients with T2DM. Improvement in BP and glucose control may contribute to reducing complications of diabetes including cardiovascular risk in these patients.
authors.affiliation: Nutritional Research Center, Department of Community nutrition, Faculty of Health & Nutrition,Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Rafraf
authors.affiliation: Nutritional Research Center, Department of Community nutrition, Faculty of Health & Nutrition,Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Behnaz
authors.initials: B
authors.lastname: Bazyun
authors.affiliation: Endocrine and Metabolism Section, Faculty of Medicine, Imam Reza Teaching Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Sarabchian
authors.affiliation: Department of Statistics and Epidemiology, Faculty of Health and Nutrition,Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Abdolrasoul
authors.initials: A
authors.lastname: Safaeiyan
authors.affiliation: Department of Biochemistry and Diet therapy, Faculty of Health & Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Seyed Jamal
authors.initials: SJ
authors.lastname: Ghaemmaghami Hezaveh
keywords: Blood pressure; Inflammation; Type 2 diabetes; Vitamin E