title: Satellite glial cells in dorsal root ganglia are activated in experimental autoimmune encephalomyelitis.
abstract: Pain is a serious and common problem with patients suffering from multiple sclerosis (MS). Very little has been done to investigate the peripheral mechanisms of pain in MS. Here we used a mouse model of experimental autoimmune encephalomyelitis (EAE) to investigate the possible contribution of satellite glial cells (SGCs) to pain in MS. EAE mice had reduced pain thresholds 10 days after disease induction. We examined dorsal root ganglia and found increased expression of glial fibrillary acidic protein in SGCs, a marker of SGC activation, and increased coupling among SGCs, a known component of activated SGCs. Activated SGCs have previously been shown to contribute to pain in other classical neuropathic pain models, suggesting that pain in multiple sclerosis has a peripheral component.
authors.affiliation: Laboratory of Experimental Surgery, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem 91240, Israel. Electronic address: rawarwick87@gmail.com.
authors.forename: Rebekah A
authors.initials: RA
authors.lastname: Warwick
authors.affiliation: Laboratory of Experimental Surgery, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem 91240, Israel.
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Ledgerwood
authors.affiliation: Department of Neurology, and the Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
authors.forename: Talma
authors.initials: T
authors.lastname: Brenner
authors.affiliation: Laboratory of Experimental Surgery, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem 91240, Israel.
authors.forename: Menachem
authors.initials: M
authors.lastname: Hanani
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005727:Ganglia, Spinal / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005904:Glial Fibrillary Acidic Protein; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010146:Pain / Q000503:physiopathology; D017288:Pain Threshold; D027161:Satellite Cells, Perineuronal / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D009419:Nerve Tissue Proteins; C528900:glial fibrillary astrocytic protein, mouse
keywords: Dorsal root ganglia; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Pain; Satellite glial cell