title: T₁ and T₂ dual-mode MRI contrast agent for enhancing accuracy by engineered nanomaterials.
abstract: One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here, we developed a dual-mode artifact filtering nanoparticle imaging agent (AFIA) that comprises a combination of paramagnetic and superparamagnetic nanomaterials. This AFIA has the ability to perform "AND logic gate" algorithm to eliminate false errors (artifacts) from the raw images to enhance accuracy of the MRI. We confirm the artifact filtering capability of AFIA in MRI phantoms and further demonstrate that artifact-free imaging of stem cell migration is possible in vivo.
authors.affiliation: Center for Evolutionary Nanoparticles (CEN), Department of Chemistry, Yonsei University , Seoul 120-749, Korea.
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Shin
authors.forename: Jin-sil
authors.initials: JS
authors.lastname: Choi
authors.forename: Seokhwan
authors.initials: S
authors.lastname: Yun
authors.forename: Il-Sun
authors.initials: IS
authors.lastname: Kim
authors.forename: Ho-Taek
authors.initials: HT
authors.lastname: Song
authors.forename: Youngmee
authors.initials: Y
authors.lastname: Kim
authors.forename: Kook In
authors.initials: KI
authors.lastname: Park
authors.forename: Jinwoo
authors.initials: J
authors.lastname: Cheon
mesh_terms: D000818:Animals; D016477:Artifacts; D001921:Brain / Q000166:cytology; D058948:Cell Tracking; D003287:Contrast Media / Q000737:chemistry; D053595:Embryonic Stem Cells / Q000166:cytology; D004738:Engineering; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D059346:Magnets / Q000737:chemistry; D008345:Manganese / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D011247:Pregnancy; D051381:Rats
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008345:Manganese