title: [Bone and Stem Cells. Regulatory mechanism of mesenchymal stem cell differentiation to osteoblasts].
abstract: Differentiation of mesenchymal stem cells to osteoblastic lineage cells is regulated positively by factors such as mechanical strain and parathyroid hormone, and is negatively regulated by factors including aging and glucocorticoids. Wnt/β-catenin pathway plays an important role in controlling the bifurcation of mesenchymal stem cell differentiation between osteoblastic and adipocytic lineages. In this review, we overview the outline of the mechanism of action as well as interrelation of the actions of these factors in controlling osteoblast differentiation, with special reference to the role of interleukin-11 in these processes.
authors.affiliation: Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, Japan.
authors.forename: Itsuro
authors.initials: I
authors.lastname: Endo
authors.forename: Toshio
authors.initials: T
authors.lastname: Mastumoto
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000166:cytology* / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D010006:Osteoblasts / Q000166:cytology* / Q000378:metabolism; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D051153:Wnt Proteins