title: Lack of clinical pharmacodynamic and pharmacokinetic drug-drug interactions between warfarin and the antisense oligonucleotide mipomersen.
abstract: Mipomersen is a second-generation antisense oligonucleotide indicated as an adjunct therapy for homozygous familial hypercholesterolemia (HoFH). Warfarin is commonly prescribed for a variety of cardiac disorders in homozygous familial hypercholesterolemia population, and concurrent use of warfarin and mipomersen is likely. This open-label, single-sequence 2-period phase 1 study in healthy subjects evaluated the potential drug-drug interactions between mipomersen and warfarin. The subjects received a single oral 25 mg dose of warfarin alone on day 1, and after a 7-day washout period, received 200 mg mipomersen alone subcutaneously every other day on days 8-12, and received both concurrently on day 14. Coadministration of mipomersen did not change the pharmacodynamics (international normalized ratio, prothrombin time, and activated partial thromboplastin time) and pharmacokinetics (PK) of warfarin. There were no clinically significant changes in the PK of mipomersen with concurrent administration of warfarin. There were no events indicative of an increase in bleeding tendency when warfarin was coadministered with mipomersen, and the adverse event profile of mipomersen did not appear to be altered in combination with warfarin, as compared with that of the respective reference treatment. The combination of these 2 medications appeared to be safe and well tolerated. These results suggest that the dosage adjustment of warfarin or mipomersen is not expected to be necessary with coadministration.
authors.affiliation: *Genzyme, A Sanofi Company, Cambridge, MA; and †Isis Pharmaceuticals, Carlsbad, CA.
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Li
authors.forename: Marjie L
authors.initials: ML
authors.lastname: Hard
authors.forename: John S
authors.initials: JS
authors.lastname: Grundy
authors.forename: Tejdip
authors.initials: T
authors.lastname: Singh
authors.forename: Lisa L
authors.initials: LL
authors.lastname: von Moltke
authors.forename: Ingrid
authors.initials: I
authors.lastname: Boltje
mesh_terms: D000293:Adolescent; D000328:Adult; D004347:Drug Interactions; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D020319:Oligodeoxyribonucleotides, Antisense / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000494:pharmacology*; D009841:Oligonucleotides / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000494:pharmacology*; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D020319:Oligodeoxyribonucleotides, Antisense; D009841:Oligonucleotides; D014859:Warfarin; C524142:mipomersen