title: Bioglass®/chitosan-polycaprolactone bilayered composite scaffolds intended for osteochondral tissue engineering.
abstract: Polymer-coated 45S5 Bioglass(®) (BG)/chitosan-polycaprolactone (BG/CS-PCL) bilayered composite scaffolds were prepared via foam replication and freeze-drying techniques for application in osteochondral tissue engineering. The CS-PCL coated and uncoated BG scaffolds were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The mechanical properties of the coated scaffolds were significantly improved in comparison to uncoated scaffolds. The bioactivity and biodegradation behavior of scaffolds were studied in simulated body fluid (SBF) for up to 28 days. The interface between the BG scaffold and the polymer coating layer was observed by SEM and a suitable interpenetration of the polymer into the scaffold struts was found. The effects of coated and uncoated BG scaffolds on MG-63 osteoblast-like cells were evaluated by cell viability, adhesion and proliferation.
authors.affiliation: Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology & Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, 325027, China; Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstrasse 6, Erlangen, 91058, Germany; Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, People's Republic of China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Yao
authors.forename: Patcharakamon
authors.initials: P
authors.lastname: Nooeaid
authors.forename: Rainer
authors.initials: R
authors.lastname: Detsch
authors.forename: Judith A
authors.initials: JA
authors.lastname: Roether
authors.forename: Yanming
authors.initials: Y
authors.lastname: Dong
authors.forename: Ourania-Menti
authors.initials: OM
authors.lastname: Goudouri
authors.forename: Dirk W
authors.initials: DW
authors.lastname: Schubert
authors.forename: Aldo R
authors.initials: AR
authors.lastname: Boccaccini
mesh_terms: D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism; D002356:Cartilage / Q000166:cytology / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D005898:Glass / Q000737:chemistry; D006801:Humans; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D011091:Polyesters; C425330:bioactive glass 45S5; C016240:polycaprolactone
keywords: bilayered scaffolds; bioglass®; chitosan; osteochondral tissue engineering; polycaprolactone