title: Copper-catalyzed electrophilic amination of heteroarenes and arenes by C-H zincation.
abstract: Direct amination of heteroarenes and arenes has been achieved in a one-pot CH zincation/copper-catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using CH amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines.
authors.affiliation: Department of Chemistry, Duke University, Durham, NC 27708-0346 (USA).
authors.forename: Stacey L
authors.initials: SL
authors.lastname: McDonald
authors.forename: Charles E
authors.initials: CE
authors.lastname: Hendrick
authors.forename: Qiu
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000577:Amides / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D000577:Amides; D000588:Amines; D006841:Hydrocarbons, Aromatic; D009942:Organometallic Compounds; D003300:Copper
keywords: CH functionalization; amination; copper; heterocycles; synthetic methods