title: An efficient and modular route to sequence-defined polymers appended to DNA.
abstract: Inspired by biological polymers, sequence-controlled synthetic polymers are highly promising materials that integrate the robustness of synthetic systems with the information-derived activity of biological counterparts. Polymer-biopolymer conjugates are often targeted to achieve this union; however, their synthesis remains challenging. We report a stepwise solid-phase approach for the generation of completely monodisperse and sequence-defined DNA-polymer conjugates using readily available reagents. These polymeric modifications to DNA display self-assembly and encapsulation behavior-as evidenced by HPLC, dynamic light scattering, and fluorescence studies-which is highly dependent on sequence order. The method is general and has the potential to make DNA-polymer conjugates and sequence-defined polymers widely available.
authors.affiliation: Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, H3A 0B8, Quebec (Canada) http://www.hanadisleiman.com.
authors.forename: Thomas G W
authors.initials: TG
authors.lastname: Edwardson
authors.forename: Karina M M
authors.initials: KM
authors.lastname: Carneiro
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Serpell
authors.forename: Hanadi F
authors.initials: HF
authors.lastname: Sleiman
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D060327:Solid-Phase Synthesis Techniques; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D004247:DNA
keywords: DNA; amphiphiles; polymers; self-assembly; solid-phase synthesis