title: Plasma vitamin D and serum total immunoglobulin E levels in patients with seasonal allergic conjunctivitis.
abstract: OBJECTIVE
  To evaluate plasma 25-hydroxyvitamin D and serum total immunoglobulin E (IgE) levels in patients with seasonal allergic conjunctivitis (SAC).
  
  
  METHODS
  This observational case-control study involved 49 patients with SAC without any other ocular and systemic diseases, and 44 consecutive, age- and sex-matched healthy subjects. Plasma 25-hydroxyvitamin D and serum total IgE levels of all subjects were quantified with electrochemiluminescence technique. Results were compared between the groups, and p values of <0.05 were considered as statistically significant.
  
  
  RESULTS
  No significant differences were found between the groups with respect to age (p = 0.41) and sex (p = 0.98). Plasma vitamin D levels of the subjects with SAC (median 8.03 ng/ml, range 3.00-17.97 ng/ml) were significantly lower than the control group (median 10.52 ng/ml, range 3.30-25.92 ng/ml) (p = 0.007). Serum total IgE levels of patients with SAC (median 48.65 IU/ml, range 1.77-812.00 IU/ml) were significantly higher when compared to the control group (median 32.49 IU/ml, range 0.14-104.60 IU/ml) (p = 0.003).
  
  
  CONCLUSIONS
  We found lower plasma vitamin D levels and higher serum total IgE levels in patients with SAC.
authors.affiliation: Department of Ophthalmology, Mevlana (Rumi) University School of Medicine, Meram, Konya, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Dadaci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Borazan
authors.forename: Aysel
authors.initials: A
authors.lastname: Kiyici
authors.forename: Nursen
authors.initials: N
authors.lastname: Oncel Acir
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D016022:Case-Control Studies; D002648:Child; D003233:Conjunctivitis, Allergic / Q000097:blood*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008163:Luminescent Measurements; D008297:Male; D011446:Prospective Studies; D017678:Sex Distribution; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D014807:Vitamin D; D007073:Immunoglobulin E; C104450:25-hydroxyvitamin D
keywords: allergy; immunoglobulin E; seasonal allergic conjunctivitis; vitamin D