title: Imperative role of dental pulp stem cells in regenerative therapies: a systematic review.
abstract: Stem cells are primitive cells that can differentiate and regenerate organs in different parts of the body such as heart, bones, muscles and nervous system. This has been a field of great clinical interest with immense possibilities of using the stem cells in regeneration of human organ those are damaged due to disease, developmental defects and accident. The knowledge of stem cell technology is increasing quickly in all medical specialties and in dental field too. Stem cells of dental origin appears to hold the key to various cell-based therapies in regenerative medicine, but most avenues are in experimental stages and many procedures are undergoing standardization and validation. Long-term preservation of SHED cells or DPSC is becoming a popular consideration, similar to the banking of umbilical cord blood. Dental pulp stem cells (DPSCs) are the adult multipotent cells that reside in the cell rich zone of the dental pulp. The multipotent nature of these DPSCs may be utilized in both dental and medical applications. A systematic review of the literature was performed using various internet based search engines (PubMed, Medline Plus, Cochrane, Medknow, Ebsco, Science Direct, Hinari, WebMD, IndMed, Embase) using keywords like "dental pulp stem cells", "regeneration", "medical applications", "tissue engineering". DPSCs appears to be a promising innovation for the re-growth of tissues however, long term clinical studies need to be carried out that could establish some authentic guidelines in this perspective.
authors.affiliation: Department of Conservative Dentistry and Endodontics, Seema Dental College and Hospital, Rishikesh, India.
authors.forename: Ramchandra
authors.initials: R
authors.lastname: Kabir
authors.affiliation: Department of Oral Medicine and Radiology, Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, Uttar Pradesh, India.
authors.forename: Manish
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Department of Oral Medicine and Radiology, Rajasthan Dental College, Jaipur, Rajasthan, India.
authors.forename: Avanti
authors.initials: A
authors.lastname: Aggarwal
authors.affiliation: Department of Conservative Dentistry and Endodontics, College of Dental Science and Hospital, Rau, Indore, Madhya Pradesh, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Sharma
authors.affiliation: Department of Conservative Dentistry, Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, Uttar Pradesh, India.
authors.forename: Anurag
authors.initials: A
authors.lastname: Sarin
authors.affiliation: Department of Prosthodontics, College of Dentistry, Salman bin Abdulaziz University, Alkharj (KSA).
authors.forename: Mohammed Zaheer
authors.initials: MZ
authors.lastname: Kola
keywords: Dental pulp stem cells; myocardial infarction; regenerative therapy; tissue engineering