title: [Effects of sucralfate and acid-suppressive drugs on preventing ventilator- associated pneumonia of mechanically ventilated patients: a meta-analysis].
abstract: OBJECTIVE
  To evaluate the effect of sucralfate and acid-suppressive drugs on preventing ventilator-associated pneumonia (VAP) in mechanically ventilated patients.
  
  
  METHODS
  All randomized controlled trials (RCTs), which studied the effect of sucralfate and acid-suppressive drugs on the incidence of VAP in mechanically ventilated patients, were searched from PubMed, Embase and the Cochrane Library during January 1966 to March 2013 via manual and computer retrieval. All related data were extracted. Meta analysis was conducted using the statistical software RevMan 5.2 and the quality of the RCTs was strictly evaluated with the methods recommended by the Cochrane Collaboration.
  
  
  RESULTS
  A total of 15 RCTs involving 1315 patients in the sucralfate group and 1568 patients in the acid-suppressive drug group were included in this study. The incidence of VAP was significantly reduced in the sucralfate group (RR = 0.81, 95%CI 0.7-0.95, P = 0.008), while no difference was found between the two groups in the incidence of stress-related gastrointestinal bleeding (RR = 0.96, 95%CI 0.59-1.58, P = 0.88). No statistical difference was found in the days on ventilator, duration of ICU stay and ICU mortality in the two groups (all P values > 0.05).
  
  
  CONCLUSIONS
  In patients with mechanical ventilation, sucralfate could decrease the incidence of VAP, while has no such effect on the stress-related gastrointestinal bleeding, the days on ventilator, duration of ICU stay and ICU mortality.
authors.affiliation: Department of Critical Care Medicine, Affiliated Zhong-Da Hospital of Southeast University, Nanjing 210009, China.
authors.forename: Hongli
authors.initials: H
authors.lastname: He
authors.affiliation: Department of Critical Care Medicine, Affiliated Zhong-Da Hospital of Southeast University, Nanjing 210009, China.
authors.forename: Shuling
authors.initials: S
authors.lastname: Hu
authors.affiliation: Department of Critical Care Medicine, Affiliated Zhong-Da Hospital of Southeast University, Nanjing 210009, China.
authors.forename: Qihong
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Critical Care Medicine, Affiliated Zhong-Da Hospital of Southeast University, Nanjing 210009, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Critical Care Medicine, Affiliated Zhong-Da Hospital of Southeast University, Nanjing 210009, China.
authors.forename: Yingzi
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Critical Care Medicine, Affiliated Zhong-Da Hospital of Southeast University, Nanjing 210009, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Critical Care Medicine, Affiliated Zhong-Da Hospital of Southeast University, Nanjing 210009, China. Email: haiboq2000@gmail.com.
authors.forename: Haibo
authors.initials: H
authors.lastname: Qiu
mesh_terms: D000863:Antacids / Q000494:pharmacology / Q000627:therapeutic use*; D006471:Gastrointestinal Hemorrhage / Q000517:prevention & control*; D006801:Humans; D053717:Pneumonia, Ventilator-Associated / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D013392:Sucralfate / Q000494:pharmacology / Q000627:therapeutic use*; D014456:Ulcer / Q000517:prevention & control*
chemical_list: D000863:Antacids; D013392:Sucralfate