title: An enteric nervous system progenitor cell implant promotes a behavioral and neurochemical improvement in rats with a 6-OHDA-induced lesion.
abstract: The enteric nervous system (ENS) of mammals is derived from neural crest (NC) cells during embryogenesis and at the beginning of postnatal life. However, neural progenitor cells from the ENS (or ENSPC) are also found in the adult intestine and can be used for neuronal regeneration in diseases that lead to a loss of cell population, such as Parkinson's disease (PD), in which there is a decrease of dopaminergic neurons. The objective of this study was to evaluate the capacity of ENSPC to restore damaged nervous tissue and to show that they are functional for a behavioral and neurochemical recovery. We found that animals with ENSPC implants exhibited a motor recovery of 35% vs. the lesion group. In addition, DA levels were partially restored in 34%, while Homovanillic acid (HVA) levels remained at 21% vs. the group with a 6-Hydroxydopamine (6-OHDA)-induced lesion, suggesting that ENSPC represent a possible alternative in the study of cell transplants and the preservation of functional dopaminergic neurons in PD.
authors.affiliation: Unidad de Ingeniería de Tejidos, Terapia Celular y Medicina Regenerativa, Instituto Nacional de Rehabilitación, Secretaría de Salud (SSA), Mexico City, Mexico. Electronic address: carmelapcid@yahoo.com.mx.
authors.forename: Carmen
authors.initials: C
authors.lastname: Parra-Cid
authors.affiliation: Unidad de Ingeniería de Tejidos, Terapia Celular y Medicina Regenerativa, Instituto Nacional de Rehabilitación, Secretaría de Salud (SSA), Mexico City, Mexico. Electronic address: garcia.juli2013@gmail.com.
authors.forename: Julieta
authors.initials: J
authors.lastname: García-López
authors.affiliation: Laboratorio de Neuroinmunología, Instituto Nacional de Neurología y Neurocirugía (INNN) MVS-SSA, Mexico City, Mexico. Electronic address: egarciainnn@gmail.com.
authors.forename: Esperanza
authors.initials: E
authors.lastname: García
authors.affiliation: Unidad de Ingeniería de Tejidos, Terapia Celular y Medicina Regenerativa, Instituto Nacional de Rehabilitación, Secretaría de Salud (SSA), Mexico City, Mexico. Electronic address: clementeibarra@yahoo.com.
authors.forename: Clemente
authors.initials: C
authors.lastname: Ibarra
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D004298:Dopamine / Q000378:metabolism*; D059290:Dopaminergic Neurons / Q000187:drug effects / Q000502:physiology; D017615:Enteric Nervous System / Q000166:cytology*; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D051379:Mice; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery*; D016627:Oxidopamine / Q000633:toxicity; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology; D013378:Substantia Nigra / Q000293:injuries / Q000378:metabolism*
chemical_list: D016627:Oxidopamine; D004298:Dopamine; D006719:Homovanillic Acid
keywords: 6-OHDA toxicity; Behavioral recovery; ENSPC; Enteric nervous system; Neurochemical imbalance