title: Selective alpha(1)-adrenoceptor blockade prevents fructose-induced hypertension.
abstract: The purpose of this study was to investigate the effect of chronic treatment with prazosin, a selective α1-adrenoceptor antagonist, on the development of hypertension in fructose-fed rats (FFR). High-fructose feeding and treatment with prazosin (1 mg/kg/day via drinking water) were initiated simultaneously in male Wistar rats. Systolic blood pressure, fasted plasma parameters, insulin sensitivity, plasma norepinephrine (NE), uric acid, and angiotensin II (Ang II) were determined following 9 weeks of treatment. FFR exhibited insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension, as well as elevations in plasma NE and Ang II levels. Treatment with prazosin prevented the rise in blood pressure without affecting insulin levels, insulin sensitivity, uric acid, or Ang II levels, while normalizing plasma NE levels in FFR. These data suggest that over-activation of the sympathetic nervous system, specifically α1-adrenoceptors, contributes to the development of fructose-induced hypertension, however, this over-activation does not appear to an initial, precipitating event in FFR.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
authors.forename: Linda T
authors.initials: LT
authors.lastname: Tran
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: MacLeod
authors.forename: John H
authors.initials: JH
authors.lastname: McNeill
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001794:Blood Pressure; D005632:Fructose / Q000009:adverse effects*; D006973:Hypertension / Q000139:chemically induced / Q000517:prevention & control*; D007333:Insulin Resistance; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011224:Prazosin / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects*; D014527:Uric Acid / Q000097:blood
chemical_list: D000317:Adrenergic alpha-Antagonists; D018340:Receptors, Adrenergic, alpha-1; D000804:Angiotensin II; D014527:Uric Acid; D005632:Fructose; D009638:Norepinephrine; D011224:Prazosin