title: [Tissue fixation in clinical practice: the 120-year-old formalin].
abstract: Formalin, the saturated watery solution of formaldehyde is used in every health care institution worldwide as an effective and cheap tissue fixative. The beneficial effect of the formaldehyde solution was discovered and published exactly 120 years ago and, despite significant technological developments, the formula is still used in the same way. However, tissue based molecular techniques including multiple gene mutation testing from isolated DNA require a highly standardized tissue preservation procedure and the strict control of the composition of the fixative solution applied.
authors.affiliation: Debreceni Egyetem, Általános Orvostudományi Kar Pathologiai Intézet Debrecen Nagyerdei krt. 98. 4032.
authors.forename: Gábor
authors.initials: G
authors.lastname: Méhes
authors.affiliation: Debreceni Egyetem, Általános Orvostudományi Kar Pathologiai Intézet Debrecen Nagyerdei krt. 98. 4032.
authors.forename: Lívia
authors.initials: L
authors.lastname: Beke
mesh_terms: D005404:Fixatives / Q000266:history*; D005557:Formaldehyde / Q000266:history*; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D016707:Tissue Fixation / Q000266:history* / Q000379:methods / Q000592:standards
chemical_list: D005404:Fixatives; D005557:Formaldehyde
keywords: concentration; formaldehid; formaldehyde; histology; koncentráció; minőségbiztosítás; molecular diagnostics; molekuláris diagnosztika; quality control; sebészi kimetszés; surgical resection; szövettan