title: Alzheimer disease in post-menopausal women: Intervene in the critical window period.
abstract: Alzheimer disease (AD) is a crippling neurodegenerative disorder. It is more common in females after menopause. Estrogen probably has a protective role in cognitive decline. Large amount of research has been carried out to see the benefits of hormone replacement therapy with regards to Alzheimer still its neuroprotective effect is not established. Recent studies suggest a reduced risk of AD and improved cognitive functioning of post-menopausal women who used 17 β-estradiol in the critical period. Use of 17 β-estradiol in young and healthy post-menopausal women yields the maximum benefit when the neurons are intact or neuronal stress has just started. Hence intervention in the critical period is key in the prevention or delay of AD in post-menopausal women.
authors.affiliation: Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Nayer
authors.initials: N
authors.lastname: Jamshed
authors.affiliation: Department of Forensic Medicine, Hamdard Institute of Medical Sciences and Research, New Delhi, India.
authors.forename: Fouzia Firdaus
authors.initials: FF
authors.lastname: Ozair
authors.affiliation: Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Aggarwal
authors.affiliation: Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Meera
authors.initials: M
authors.lastname: Ekka
keywords: 17 β-estradiol; Alzheimer disease; critical period; post-menopausal