title: Chromosomal anomalies in primary cutaneous follicle center cell lymphoma do not portend a poor prognosis.
abstract: BACKGROUND
  The t(14;18)(q32;q21) chromosomal translocation is found in the majority of nodal follicular lymphomas but only rarely in primary cutaneous follicle center cell lymphomas (PCFCL). Recent studies have postulated that the translocation is more prevalent in PCFCL than previously described and that it might be a molecular prognostic marker.
  
  
  OBJECTIVE
  The purpose of our study was to analyze cases of PCFCL for the presence of a t(14;18) translocation using fluorescence in situ hybridization to detect balanced translocations involving either the BCL2 or MALT1 loci and to correlate the results with growth pattern, immunophenotype, and clinical outcome.
  
  
  METHODS
  In all, 57 patients with PCFCL were extracted from our cutaneous lymphoma database. Retrospective analysis of clinical parameters including lesion type, location, diagnostic stage, lactate dehydrogenase, initial treatment, relapse rate, and survival was performed.
  
  
  RESULTS
  In all, 57 patients with PCFCL were included in this study. We detected 1 BCL2 chromosomal amplification, 4 translocations of BCL2, and 1 IGH/MALT1 translocation.
  
  
  CONCLUSIONS
  This was a case series retrospective study.
  
  
  CONCLUSIONS
  PCFCL has an excellent 5-year overall survival (100% disease-specific survival). Chromosomal abnormalities of either BCL2 or MALT1 were detected in 10% of cases but do not correlate with a specific immune pathology or clinical outcome.
authors.affiliation: Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom. Electronic address: alyawahab@gmail.com.
authors.forename: Alya
authors.initials: A
authors.lastname: Abdul-Wahab
authors.affiliation: Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom.
authors.forename: Soo-Yong
authors.initials: SY
authors.lastname: Tang
authors.affiliation: Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom.
authors.forename: Alistair
authors.initials: A
authors.lastname: Robson
authors.affiliation: Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom.
authors.forename: Stephen
authors.initials: S
authors.lastname: Morris
authors.affiliation: Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom.
authors.forename: Nita
authors.initials: N
authors.lastname: Agar
authors.affiliation: Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom.
authors.forename: E Mary
authors.initials: EM
authors.lastname: Wain
authors.affiliation: Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom.
authors.forename: Fiona
authors.initials: F
authors.lastname: Child
authors.affiliation: Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom.
authors.forename: Julia
authors.initials: J
authors.lastname: Scarisbrick
authors.affiliation: Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom.
authors.forename: Michael
authors.initials: M
authors.lastname: Neat
authors.affiliation: Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom.
authors.forename: Sean
authors.initials: S
authors.lastname: Whittaker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D015331:Cohort Studies; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D008224:Lymphoma, Follicular / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D016019:Survival Analysis; D014178:Translocation, Genetic; D016896:Treatment Outcome
chemical_list: D009363:Neoplasm Proteins
keywords: B-cell lymphoma; BCL2 translocation; disease-free survival; fluorescence in situ hybridization; primary cutaneous follicle center cell lymphoma; t(14;18) translocation