title: Optimization of surgical ventricular restoration by in-silico simulations.
abstract: OBJECTIVE
  A hypothesis on left ventricular aneurysms states that there is better preservation of contractile myocardium when the aneurysm geometry is rectangular as opposed to circular. Pre-surgical planning of surgical ventricular restoration was performed on the basis of this hypothesis.
  
  
  METHODS
  The intraventricular patch used to exclude scarred or aneurysmal myocardium remains akinetic, hence it was used to define aneurysm geometry as circular or rectangular. Hausdorff distance analysis was carried out by mathematical computational methods on the baseline cardiac magnetic resonance images of 5 patients.
  
  
  RESULTS
  The mean Hausdorff distance for the full range of frequencies was significantly greater after endoventricular linear patch plasty (0.474 ± 0.190 vs. 0.722 ± 0.221 mm, p = 0.047), whereas after endoventricular circular patch plasty, the difference was not significant (0.474 ± 0.190 vs. 0.594 ± 0.193, p = 0.175). The mean Hausdorff distance <0.5 mm was also significantly greater after endoventricular linear patch plasty than after endoventricular circular patch plasty: 0.258 ± 0.03 mm at baseline vs. 0.40 ± 0.16 mm after linear patch plasty (p = 0.039) and 0.258 ± 0.03 vs. 0.32 ± 0.10 mm (p = 0.130) after circular patch plasty.
  
  
  CONCLUSIONS
  In-silico technology using the Hausdorff distance enables pre-surgical planning and optimization of the technique for surgical ventricular restoration.
authors.affiliation: Department of Cardiology, St. John's Medical College Hospital, Bangalore, India srili2881967@yahoo.com.
authors.forename: Srilakshmi M
authors.initials: SM
authors.lastname: Adhyapak
authors.affiliation: Department of Electrical and Computer Engineering, SYSU-CMU Joint Institute of Engineering, Pittsburgh, USA Shunde International Research Institute, Guangdong, China Quant MD, Pittsburgh, USA.
authors.forename: Prahlad G
authors.initials: PG
authors.lastname: Menon
authors.affiliation: Department of Cardiac Surger, Narayana Hrudayalaya Institute of Medical Sciences, Bangalore, India.
authors.forename: Venkateswara Rao
authors.initials: VR
authors.lastname: Parachuri
mesh_terms: D000328:Adult; D006348:Cardiac Surgical Procedures / Q000379:methods*; D003198:Computer Simulation; D005260:Female; D006322:Heart Aneurysm / Q000473:pathology / Q000601:surgery*; D006352:Heart Ventricles / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D019919:Prosthesis Implantation / Q000379:methods*
keywords: Heart aneurysm; cardiovascular; heart ventricles; models; myocardial infarction; prostheses and implants; ventricular remodeling