title: Therapeutic potential of leptin receptor modulators.
abstract: Leptin, a pleiotropic molecule mainly produced by adipose tissue, was first discovered as a hormone controlling body weight and energy expenditure. In addition, leptin can modulate several processes in peripheral tissues such as immune response, fertility, hematopoiesis and carcinogenesis. The development of molecules that block or stimulate leptin receptor may therefore serve as a potent tool for studying the role of leptin in mammalian physiology and pathology, but it also may open new possibilities for therapy. This article presents an overview of current knowledge on leptin receptor modulators focusing on leptin mutein, leptin peptide modulators as well as small molecules with heterocyclic structure.
authors.affiliation: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Edificio Polifunzionale, 87036 Arcavacata di Rende, CS, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Leggio
authors.affiliation: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Edificio Polifunzionale, 87036 Arcavacata di Rende, CS, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Catalano
authors.affiliation: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Edificio Polifunzionale, 87036 Arcavacata di Rende, CS, Italy.
authors.forename: Rosaria
authors.initials: R
authors.lastname: De Marco
authors.affiliation: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Edificio Polifunzionale, 87036 Arcavacata di Rende, CS, Italy.
authors.forename: Ines
authors.initials: I
authors.lastname: Barone
authors.affiliation: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Edificio Polifunzionale, 87036 Arcavacata di Rende, CS, Italy. Electronic address: sebastiano.ando@unical.it.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Andò
authors.affiliation: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Edificio Polifunzionale, 87036 Arcavacata di Rende, CS, Italy. Electronic address: a.liguori@unical.it.
authors.forename: Angelo
authors.initials: A
authors.lastname: Liguori
mesh_terms: D000818:Animals; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D008958:Models, Molecular; D054411:Receptors, Leptin / Q000378:metabolism; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D006571:Heterocyclic Compounds; D020738:Leptin; D054411:Receptors, Leptin; D054852:Small Molecule Libraries
keywords: Agonists; Antagonists; Leptin; Leptin receptor; Leptin receptor modulators; Leptin-related diseases