title: Double-pulsed diffusional kurtosis imaging.
abstract: Diffusional kurtosis imaging (DKI) is extended to double-pulsed-field-gradient (d-PFG) diffusion MRI sequences. This gives a practical approach for acquiring and analyzing d-PFG data. In particular, the leading d-PFG effects, beyond what conventional single-pulsed field gradient (s-PFG) provides, are interpreted in terms of the kurtosis for a diffusion displacement probability density function (dPDF) in a six-dimensional (6D) space. The 6D diffusional kurtosis encodes the unique information provided by d-PFG sequences up to second order in the b-value. This observation leads to a compact expression for the signal magnitude, and it suggests novel data acquisition and analysis methods. Double-pulsed DKI (DP-DKI) is demonstrated for in vivo mouse brain with d-PFG data obtained at 7 T. Copyright © 2014 John Wiley & Sons, Ltd.
authors.affiliation: Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA; Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Jens H
authors.initials: JH
authors.lastname: Jensen
authors.forename: Edward S
authors.initials: ES
authors.lastname: Hui
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Helpern
keywords: MRI; diffusion; double-pulsed field gradient; kurtosis; microscopic anisotropy; mouse; non-Gaussian; tensor