title: The efficacy and safety of topiramate for prophylaxis of migraine in children.
abstract: OBJECTIVE
  Migraine is the most common acute intermittent primary headache in children and prophylactic therapy is indicated in children with frequent or disabling headaches. The purpose of this study was to evaluate the efficacy and safety of topiramate (TPM) for migraine prophylaxis in children.
  
  
  METHODS
  In a quasi-experimental study, monthly frequency, severity and duration of headache, migraine disability, and side-effects were evaluated in 100 children who were referred to the Pediatric Neurology Clinic of Shahid Sadoughi University of Medical Sciences, Yazd, Iran from April 2011 to March 2012, and were treated with 3 mg/kg/day of TPM for three months.
  
  
  RESULTS
  Fifty eight (57.4%) girls and 42 (41.6%) boys with the mean age of 10.46±2.11 years were evaluated. Monthly frequency, severity, and duration of headache decreased with treatment from 15.34±7.28 to 6.07±3.16 attacks, from 6.21±1.74 to 3.15±2.22, and from 2.28±1.55 to 0.94±0.35 hours, respectively, and the Pediatric Migraine Disability Assessment score reduced with TPM from 32.48±9.33 to 15.54±6.16. Transient side-effects were seen in 21% of the patients, including hyperthermia in 11%, anorexia and weight loss in 6%, and drowsiness in 4%. No serious side-effects were reported.
  
  
  CONCLUSIONS
  TPM could be considered as a safe and effective drug in pediatric migraine prophylaxis.
authors.affiliation: Growth Disorders of Children Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ; Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Razieh
authors.initials: R
authors.lastname: Fallah
authors.affiliation: Growth Disorders of Children Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ; Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Sedighah
authors.initials: S
authors.lastname: Akhavan Karbasi
authors.affiliation: Department of Pediatrics, Aliebn-Abitaleb School of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Shajari
authors.affiliation: Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Fromandi
keywords: Headache; Migraine; Prophylaxis; Topiramate