title: Deoxysugars as antituberculars and alpha-mannosidase inhibitors.
abstract: A promising modified sugar molecule was identified which was active against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in mice, and targeted alpha-mannosidase as a competitive inhibitor with a Ki value of 353.9 μM.
authors.affiliation: Division of Microbiology, CSIR-Central Drug Research Institute, Janakipuram Extension, Lucknow, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Kashyap
authors.affiliation: Process & Medicinal Chemistry Division, CSIR Central Drug Research Institute, Janakipuram Extension, Lucknow, India.
authors.forename: Smriti
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Division of Microbiology, CSIR-Central Drug Research Institute, Janakipuram Extension, Lucknow, India.
authors.forename: Vinayak
authors.initials: V
authors.lastname: Singh
authors.affiliation: Division of Microbiology, CSIR-Central Drug Research Institute, Janakipuram Extension, Lucknow, India.
authors.forename: Sandeep K
authors.initials: SK
authors.lastname: Sharma
authors.affiliation: Process & Medicinal Chemistry Division, CSIR Central Drug Research Institute, Janakipuram Extension, Lucknow, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Saquib
authors.affiliation: Division of Microbiology, CSIR-Central Drug Research Institute, Janakipuram Extension, Lucknow, India akshaw55@yahoo.com ranjanasrivastava5@gmail.com.
authors.forename: Ranjana
authors.initials: R
authors.lastname: Srivastava
authors.affiliation: Process & Medicinal Chemistry Division, CSIR Central Drug Research Institute, Janakipuram Extension, Lucknow, India akshaw55@yahoo.com ranjanasrivastava5@gmail.com.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Shaw
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D003837:Deoxy Sugars / Q000494:pharmacology*; D004195:Disease Models, Animal; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000382:microbiology; D043323:alpha-Mannosidase / Q000037:antagonists & inhibitors*
chemical_list: D000995:Antitubercular Agents; D003837:Deoxy Sugars; D043323:alpha-Mannosidase