title: A method to predict edge strands in beta-sheets from protein sequences.
abstract: There is a need for rules allowing three-dimensional structure information to be derived from protein sequences. In this work, consideration of an elementary protein folding step allows protein sub-sequences which optimize folding to be derived for any given protein sequence. Classical mechanics applied to this system and the energy conservation law during the elementary folding step yields an equation whose solutions are taken over the field of rational numbers. This formalism is applied to beta-sheets containing two edge strands and at least two central strands. The number of protein sub-sequences optimized for folding per amino acid in beta-strands is shown in particular to predict edge strands from protein sequences. Topological information on beta-strands and loops connecting them is derived for protein sequences with a prediction accuracy of 75%. The statistical significance of the finding is given. Applications in protein structure prediction are envisioned such as for the quality assessment of protein structure models.
authors.affiliation: Analyse algébrique, Institut de Mathématiques de Jussieu, Université Pierre et Marie Curie, Paris VI, France.
authors.forename: Antonin
authors.initials: A
authors.lastname: Guilloux
authors.affiliation: Centre d'Informatique pour la Biologie, Institut Pasteur, Paris, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Caudron
authors.affiliation: Département de Virologie, Institut Pasteur, Paris, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Jestin
keywords: Protein structure; beta-strands; central strand; loop; structure prediction; topology; turn