title: Histopathological and immunohistochemical findings of primary and metastatic medullary thyroid carcinoma in a young dog.
abstract: This report describes the gross, histological, and immunohistochemical features of medullary thyroid carcinoma (MTC) with pulmonary metastases in a young dog. Sheets of pleomorphic cells supported by fibrous stroma characterized the primary mass, while metastatic nodules had a neuroendocrine pattern. Despite differing histologic features, all masses showed marked immunoreactivity against calcitonin and multiple neuroendocrine markers consistent with MTC. Although MTC is a well-recognized entity, it may be difficult to distinguish this mass from other thyroid neoplasms, necessitating immunohistochemical characterization.
authors.affiliation: Department of Biomedical Sciences and Pathobiology and 3Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.pablop@vt.edu.
authors.forename: Pablo
authors.initials: P
authors.lastname: Piñeyro
authors.forename: Miranda D
authors.initials: MD
authors.lastname: Vieson
authors.forename: José A
authors.initials: JA
authors.lastname: Ramos-Vara
authors.forename: Martha
authors.initials: M
authors.lastname: Moon-Larson
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Saunders
mesh_terms: D000818:Animals; D018278:Carcinoma, Neuroendocrine / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D004285:Dogs; D005260:Female; D007822:Laryngeal Neoplasms / Q000556:secondary / Q000662:veterinary; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D009362:Neoplasm Metastasis; D011859:Radiography; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*
keywords: calcitonin; histopathology; immunohistochemistry; medullary thyroid carcinoma