title: Association between serum soluble low-density lipoprotein receptor levels and metabolic factors in healthy Japanese individuals.
abstract: BACKGROUND
  Soluble low-density lipoprotein receptor (sLDL-R) is formed by cleavage of the extracellular domain of low-density lipoprotein receptor (LDL-R). It is unclear whether serum sLDL-R is a marker of diseases associated with triglyceride (TG) metabolism. We investigated the association between serum sLDL-R concentrations and other biochemical parameters in healthy Japanese individuals.
  
  
  METHODS
  Study subjects consisted of 102 healthy adult Japanese volunteers (42 men, 60 women) with body mass index (BMI) < 30 kg/m(2) and serum TGs, LDL cholesterol (LDL-C), aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transpeptidase, and glucose concentrations within normal ranges. Serum sLDL-R concentrations were determined by enzyme-linked immunosorbent assay and their correlations with biochemical parameters were analyzed.
  
  
  RESULTS
  Mean serum sLDL-R concentration was 120.9 ± 39.9 ng/ml. Serum sLDL-R levels were significantly and positively correlated with BMI (rs = 0.252) and TG (rs = 0.408) and LDL-C (rs = 0.325) concentrations. Multiple regression analysis adjusted for age, gender, and smoking showed that BMI (β = 0.274), TG (β = 0.328), and LDL-C (β = 0.224) were factors independently correlated with sLDL-R levels.
  
  
  CONCLUSIONS
  Serum sLDL-R concentration may be a marker of diseases associated with TG metabolism. This is the first report to date describing the clinical relevance of sLDL-R.
authors.affiliation: Department of Pathobiological Science and Technology, School of Health Science, Faculty of Medicine, Tottori University, Yonago, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shimohiro
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Taniguchi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Koda
authors.forename: Chieko
authors.initials: C
authors.lastname: Sakai
authors.forename: Sadako
authors.initials: S
authors.lastname: Yamada
mesh_terms: D051722:ADAM Proteins / Q000097:blood; D000072198:ADAM17 Protein; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D044466:Asian People; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000502:physiology*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016014:Linear Models; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011973:Receptors, LDL / Q000097:blood*; D018709:Statistics, Nonparametric; D000637:Transaminases / Q000097:blood*; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D001786:Blood Glucose; D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D005723:gamma-Glutamyltransferase; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D051722:ADAM Proteins; D000072198:ADAM17 Protein; C000606462:ADAM17 protein, human
keywords: ADAM17; ELISA; TG metabolism; ectodomain shedding; sLDL-R