title: Intercellular adhesion molecule-1 as a drug target in asthma and rhinitis.
abstract: Intercellular adhesion molecule-1 (ICAM-1) is a transmembrane glycoprotein receptor of the immunoglobulin superfamily. Endothelial cells, epithelial cells, leukocytes and neutrophils are the major cells expressing ICAM-1. Ligands of ICAM-1 are macrophage adhesion ligand-1, leukocyte function-associated antigen-1 and fibrinogen (extracellular matrix protein). In normal physiological conditions, engagement of ICAM-1 receptor with immunological cells surface ligands assists in homing and trafficking of inflammatory cells to distant tissues. ICAM-1 has also long been known to mediate cell-to-cell interaction during antigen presentation and outside-in cell signalling pathways. ICAM-1-mediated elevated inflammation is implicated in asthma. On respiratory epithelial cells surface, ICAM-1 acts as natural binding site for human rhinovirus (HRV), a common cold virus that ultimately causes exacerbation of asthma. This review presents the findings on the role of ICAM-1 in the complication of asthma and in particular asthma exacerbation by HRV.
authors.affiliation: Department of Immunopathology, Research Block A, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Srirupa
authors.initials: S
authors.lastname: Mukhopadhyay
authors.forename: Parth
authors.initials: P
authors.lastname: Malik
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Arora
authors.forename: Tapan K
authors.initials: TK
authors.lastname: Mukherjee
mesh_terms: D001249:Asthma / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors*; D002450:Cell Communication / Q000187:drug effects / Q000276:immunology; D003139:Common Cold / Q000150:complications* / Q000276:immunology / Q000821:virology; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology*; D058990:Molecular Targeted Therapy; D020545:Respiratory Mucosa / Q000378:metabolism; D012220:Rhinitis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D012229:Rhinovirus / Q000472:pathogenicity
chemical_list: D015815:Cell Adhesion Molecules; D007155:Immunologic Factors; D018799:Intercellular Adhesion Molecule-1
keywords: ICAM-1; asthma; human rhinovirus; inflammation; rhinitis.