title: A novel cell death gene acts to repair patterning defects in Drosophila melanogaster.
abstract: Cell death is a mechanism utilized by organisms to eliminate excess cells during development. Here, we describe a novel regulator of caspase-independent cell death, Mabiki (Mabi), that is involved in the repair of the head patterning defects caused by extra copies of bicoid in Drosophila melanogaster. Mabiki functions together with caspase-dependent cell death mechanisms to provide robustness during development.
authors.affiliation: Department of Population Genetics, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540, Japan Department of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, United Kingdom fruitfly@kit.ac.jp p0037755@brookes.ac.uk.
authors.forename: Kentaro M
authors.initials: KM
authors.lastname: Tanaka
authors.affiliation: Department of Population Genetics, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540, Japan Department of Biological Sciences, Tokyo Metropolitan University, Hachioji, 192-0397, Japan Research Center for Genomics and Bioinformatics, Tokyo Metropolitan University, Hachioji, 192-0397, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Takahashi
authors.affiliation: Department of Biophysics, Kyoto University, Kitashirakawa-Oiwake-cho, Sakyo-ku, Kyoto, 606-8502, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Fuse
authors.affiliation: Department of Population Genetics, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540, Japan Drosophila Genetic Resource Center, Kyoto Institute of Technology, Saga Ippongi-cho, Ukyo-ku, Kyoto, 616-8354, Japan fruitfly@kit.ac.jp p0037755@brookes.ac.uk.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takano-Shimizu-Kouno
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D016923:Cell Death / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D055785:Gene Knockdown Techniques; D006257:Head / Q000196:embryology
chemical_list: D029721:Drosophila Proteins
keywords: Drosophila melanogaster; bicoid; developmental robustness; embryogenesis; p35-insensitive cell death