title: Atypical femoral fractures in association with bisphosphonate therapy: a case series.
abstract: Well-established clinically as frontline therapy in the management of osteoporosis, bisphosphonates have been shown in numerous trials to be highly effective in reducing the risk of both vertebral and hip fractures. More recently, however, in a multitude of exhaustive case reviews, attention has been raised to the small but by now well-established link between prolonged bisphosphonate usage and the risk for atypical subtrochanteric femoral stress fractures. We present herein a trio of illustrative cases highlighting both clinical presentation and characteristic radiological findings thereof, as well as a discussion of the background, management, and natural history of these oftentimes problematic injuries.
authors.affiliation: Department of Radiology, Henry Ford Hospital, Detroit, MI, USA, mrheinbold@yahoo.com.
authors.forename: Matthew
authors.initials: M
authors.lastname: Rheinboldt
authors.forename: Derrick
authors.initials: D
authors.lastname: Harper
authors.forename: Michael
authors.initials: M
authors.lastname: Stone
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D005264:Femoral Fractures / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006620:Hip Fractures / Q000139:chemically induced / Q000000981:diagnostic imaging; D006801:Humans; D008875:Middle Aged; D011859:Radiography
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates