title: Update on testicular germ cell tumors.
abstract: OBJECTIVE
  This overview discusses several important developments in testicular germ cell tumors (TGCTs) over the past year.
  
  
  RESULTS
  Genomic studies continue to investigate gene expression as possible markers for disease relapse and metastatic potential. Optimal treatment strategies for early-stage seminomas continue to evolve toward surveillance versus chemotherapy, although developing radiation delivery modalities may ultimately provide a safe alternative. The role of retroperitoneal lymph node dissection in postorchiectomy early-stage nonseminoma germ cell tumors remains a topic of debate.
  
  
  CONCLUSIONS
  Treatment paradigms continue to be refined for TGCTs as research in these areas continues.
authors.affiliation: aDepartment of Medicine, University of Maryland School of Medicine bBaltimore Veterans Affairs Medical Center cDepartment of Medicine, Pathology and Biochemistry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
authors.forename: Anitha
authors.initials: A
authors.lastname: Nallu
authors.forename: Roja
authors.initials: R
authors.lastname: Chimakurthi
authors.forename: Arif
authors.initials: A
authors.lastname: Hussain
authors.forename: Heather D
authors.initials: HD
authors.lastname: Mannuel
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics / Q000628:therapy*; D012307:Risk Factors; D016879:Salvage Therapy / Q000379:methods; D013736:Testicular Neoplasms / Q000235:genetics / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents