title: Safety and efficacy of a novel injectable filler in the treatment of nasolabial folds: polymethylmethacrylate and cross-linked dextran in hydroxypropyl methylcellulose.
abstract: Nasolabial folds are a sign of aging and increasing number of people want filler injections in their nasolabial folds to look younger. Various dermal fillers are used for the correction of nasolabial folds. Recently, a novel injectible filler, polymethylmethacrylate (PMMA) and cross-linked dextran in hydroxypropyl methylcellulose, was introduced for facial contouring. This study was designed as a six-month, prospective, single-blinded, and open-label study in two centers located in Korea. Nineteen Korean patients received the novel filler injections on both nasolabial folds. At Weeks 4, 12, and 24, the efficacy and safety of the dermal filler were evaluated by blinded-investigators using clinical photographs. The mean Wrinkle Severity Rating Scale revealed significant decrease after dermal filler injections at each study visit. The decreased Wrinkle Severity Rating Scale was maintained for 6 months (p < 0.0001). The Global Aesthetic Improvement score showed an improvement greater than 2 in 95% of the per-proto col population 24 weeks after the injections. All patients (100%) experienced an improvement of their nasolabial folds at Week 24. There were no complications related to the novel filler injection. The novel dermal filler, PMMA, and cross-linked dextran in hydroxylpropyl methylcellulose, can be another safe and effective treatment option in the treatment of nasolabial folds.
authors.affiliation: Department of Dermatology, College of Medicine, the Catholic University of Korea , Seoul , Republic of Korea.
authors.forename: Young Bok
authors.initials: YB
authors.lastname: Lee
authors.forename: Eun Jong
authors.initials: EJ
authors.lastname: Song
authors.forename: Sang Seok
authors.initials: SS
authors.lastname: Kim
authors.forename: Jin Wou
authors.initials: JW
authors.lastname: Kim
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Yu
mesh_terms: D000328:Adult; D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000009:adverse effects; D003911:Dextrans / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D065347:Hypromellose Derivatives / Q000008:administration & dosage* / Q000009:adverse effects; D007271:Injections, Intradermal; D007279:Injections, Subcutaneous; D008875:Middle Aged; D060052:Nasolabial Fold; D010781:Photography; D019904:Polymethyl Methacrylate / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D015361:Rhytidoplasty; D016037:Single-Blind Method; D015595:Skin Aging
chemical_list: D001672:Biocompatible Materials; D003911:Dextrans; D065347:Hypromellose Derivatives; D019904:Polymethyl Methacrylate
keywords: dermal filler; dextran; hydroxypropyl methylcellulose; polymethylmethacrylate