title: Metabolomics in hypertension.
abstract: Hypertension is the most prevalent chronic medical condition and a major risk factor for cardiovascular morbidity and mortality. In the majority of hypertensive cases, the underlying cause of hypertension cannot be easily identified because of the heterogeneous, polygenic and multi-factorial nature of hypertension. Metabolomics is a relatively new field of research that has been used to evaluate metabolic perturbations associated with disease, identify disease biomarkers and to both assess and predict drug safety and efficacy. Metabolomics has been increasingly used to characterize risk factors for cardiovascular disease, including hypertension, and it appears to have significant potential for uncovering mechanisms of this complex disease. This review details the analytical techniques, pre-analytical steps and study designs used in metabolomics studies, as well as the emerging role for metabolomics in gaining mechanistic insights into the development of hypertension. Suggestions as to the future direction for metabolomics research in the field of hypertension are also proposed.
authors.affiliation: aMenzies Research Institute Tasmania, University of Tasmania, Hobart bSchool of Human Life Sciences, University of Tasmania, Launceston, Australia cCentre of Human & Aerospace Physiological Sciences, King's College London, London, UK.
authors.forename: Sonja B
authors.initials: SB
authors.lastname: Nikolic
authors.forename: James E
authors.initials: JE
authors.lastname: Sharman
authors.forename: Murray J
authors.initials: MJ
authors.lastname: Adams
authors.forename: Lindsay M
authors.initials: LM
authors.lastname: Edwards
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000401:mortality; D002986:Clinical Trials as Topic; D006801:Humans; D006973:Hypertension / Q000378:metabolism* / Q000401:mortality; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D055432:Metabolomics; D015203:Reproducibility of Results; D012307:Risk Factors
chemical_list: D015415:Biomarkers