title: Impaired upper alpha synchronisation during working memory retention in depression and depression following traumatic brain injury.
abstract: Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are higher than in the general population. Individuals with depression following traumatic brain injury (TBI-MDD) exhibit working memory (WM) impairments. Electrophysiological evidence has suggested that parieto-occipital upper alpha synchronisation may enhance WM retention by inhibiting irrelevant processes. The current research assessed whether retention period WM parieto-occipital upper alpha activity is disrupted in groups with TBI-only (N=20), MDD (N=17), and TBI-MDD (N=15) compared to healthy controls (N=31). Behavioural data indicated poorer performance in MDD and TBI-MDD. Parietal-occipital upper alpha was reduced in the MDD and TBI-MDD groups, but was unaffected in TBI-only. These results suggest inhibitory deficits may account for WM impairments in MDD and TBI-MDD, and that for individuals with TBI-MDD it may be the depression rather than the TBI that impairs WM.
authors.affiliation: Monash Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, Central Clinical School, Melbourne, VIC, Australia. Electronic address: neilwbailey@gmail.com.
authors.forename: Neil W
authors.initials: NW
authors.lastname: Bailey
authors.affiliation: Monash Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, Central Clinical School, Melbourne, VIC, Australia.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Segrave
authors.affiliation: Monash Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, Central Clinical School, Melbourne, VIC, Australia.
authors.forename: Kate E
authors.initials: KE
authors.lastname: Hoy
authors.affiliation: Monash Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, Central Clinical School, Melbourne, VIC, Australia.
authors.forename: Jerome J
authors.initials: JJ
authors.lastname: Maller
authors.affiliation: Monash Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, Central Clinical School, Melbourne, VIC, Australia.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Fitzgerald
mesh_terms: D000293:Adolescent; D000328:Adult; D000513:Alpha Rhythm / Q000502:physiology*; D001930:Brain Injuries / Q000150:complications*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D003863:Depression / Q000150:complications* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012153:Retention, Psychology / Q000502:physiology*; D012720:Severity of Illness Index; D015599:Trauma Severity Indices; D055815:Young Adult
keywords: Alpha; EEG; Major depression; Traumatic brain injury; Working memory