title: ABCA1 rs1883025 polymorphism shows no association with neovascular age-related macular degeneration or polypoidal choroidal vasculopathy in a Northern Chinese population.
abstract: OBJECTIVE
  To analyze the association between ABCA1 rs1883025 variants with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in a northern Chinese population.
  
  
  METHODS
  The study enrolled 900 subjects, including 300 controls, 300 cases with nAMD and 300 cases with PCV. Genomic DNA was extracted from venous blood leukocytes. Single-nucleotide polymorphisms in the ABCA1 (rs1883025) gene were genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
  
  
  RESULTS
  The ABCA1 rs1883025 polymorphism was not significantly associated with nAMD (22.5%; p > 0.05) or PCV (20.8%; p > 0.05) in a northern Chinese population. The association remained insignificant after adjustment for age and gender differences (p > 0.05).
  
  
  CONCLUSIONS
  This study suggests that ABCA1 rs1883025 variants are not associated with nAMD or PCV in a Chinese population, which is likely due to an ethnic difference.
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
authors.forename: Fangting
authors.initials: F
authors.lastname: Li
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Li
authors.forename: Mingwu
authors.initials: M
authors.lastname: Li
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Sun
authors.forename: Yujing
authors.initials: Y
authors.lastname: Bai
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.forename: Lvzhen
authors.initials: L
authors.lastname: Huang
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Li
mesh_terms: D064286:ATP Binding Cassette Transporter 1 / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D020256:Choroidal Neovascularization / Q000235:genetics*; D005260:Female; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011127:Polyps / Q000235:genetics*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D057135:Wet Macular Degeneration / Q000235:genetics*
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1