title: [Preparation and in vitro evaluation of doxorubicin-loaded magnetic iron oxide nanoparticles].
abstract: PEG-modified magnetic Fe3O4 (Fe3O4-PEG) nanoparticles were sythesized using a solvothermal reaction and characterized with transmission electron microscopy (TEM) and thermo gravimetric analysis (TGA). The photothermal effect and photothermal destruction of cancer cells were evaluated. Then the doxorubicin loaded Fe3O4-PEG (DOX-Fe3O4-PEG) nanoparticles were prepared. The cytotoxicity and combined chemotherapy/photothermal therapy (PTT) effect were investigated. Uniform PEG coated Fe3O4 nanoparticles with particle size of 155 nm were obtained in the experiment. The loading and release of doxorubicin on Fe3O4-PEG were pH-dependent. The drug loading capacity in water was 21%. The results of MTT indicated a good biocompatiblity of Fe3O4-PEG nanoparticles and high cytotoxicity of DOX-Fe3O4-PEG. In combined therapy experiment, photothermal therapy demonstrated unambiguously enhanced chemotherapy efficacy. In conclusion, the obtained Fe3O4-PEG nanoparticles which exhibit good photothermal effect and drug loading capacity can be used for chemotherapy and photothermal therapy. The synergetic anti-tumor activity indicates the potential for the combined application of chemotherapy and photothermal therapy in cancer treatment.
authors.forename: Song
authors.initials: S
authors.lastname: Shen
authors.forename: Lin
authors.initials: L
authors.lastname: Wu
authors.forename: Cheng-Run
authors.initials: CR
authors.lastname: Wang
authors.forename: Xue-Yong
authors.initials: XY
authors.lastname: Qi
authors.forename: Yan-Ru
authors.initials: YR
authors.lastname: Ge
authors.forename: Yi
authors.initials: Y
authors.lastname: Jin
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D004337:Drug Carriers; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced; D061986:MCF-7 Cells; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D011092:Polyethylene Glycols; D004317:Doxorubicin; D052203:Ferrosoferric Oxide