title: In-vitro anti-inflammatory and mosquito larvicidal efficacy of nickel nanoparticles phytofabricated from aqueous leaf extracts of Aegle marmelos Correa.
abstract: In recent years there is a tremendous growth in the interdisciplinary world of nanotechnology across the globe and emergence of its potential applications remains as a big revolution to the industry. Fusion of green nanotechnology and medicine represents one of the major breakthroughs of modern science with the aim of developing nanomaterials for diagnosis, treatment, prevention of various diseases and overall improving health for the beneficial of mankind. In the present study phytofabrication of nickel nanoparticles (nickel NPs) was carried out by using indigenous Aegle marmelos Correa aqueous leaf extracts as a reducing, stabilizing and capping agents. Nickel NPs were characterized by UV-spectroscopy, FTIR, XRD, SEM, AFM and TGA studies. Phytosynthesis of nickel NPs was monitored both at room temperature (25°C) and at 60°C for 5h. The green synthesis of triangular shape nickel NPs phytofabricated from A. marmelos Correa aqueous leaf extracts having face centered cubic structure showing an average particle size of 80-100nm which is in consistent with the particle size calculated by XRD Scherer equation. We further explored and compared nickel NPs of A. marmelos Correa with crude leaf extracts of A. marmelos Correa for its in-vitro anti-inflammatory and mosquito larvicidal efficacy against three blood feeding parasites. The results obtained clearly gives an idea that nickel NPs of A. marmelos Correa (NiNPs of AmC) possess an enhanced anti-inflammatory and larvicidal activity when compared to crude leaf extracts of A. marmelos Correa.
authors.affiliation: Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, Tamil Nadu, India.
authors.forename: Gangadhara
authors.initials: G
authors.lastname: Angajala
authors.affiliation: Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, Tamil Nadu, India.
authors.forename: R
authors.initials: R
authors.lastname: Ramya
authors.affiliation: Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, Tamil Nadu, India. Electronic address: dr.subashini.r@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Subashini
mesh_terms: D045471:Aegle / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D009033:Culicidae; D007306:Insecticides / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D018625:Microscopy, Atomic Force; D008854:Microscopy, Electron; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D009532:Nickel / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D000893:Anti-Inflammatory Agents; D007306:Insecticides; D010936:Plant Extracts; D009532:Nickel
keywords: Aegle marmelos Correa; Anti-inflammatory activity; Larvicidal efficacy; Nickel nanoparticles