title: Assessing Myocardial Disease Using T1ρMRI.
abstract: There is great interest to use magnetic resonance imaging (MRI) for non-invasive assessment of myocardial disease in ischemic and non-ischemic cardiomyopathies. Recently, there has been a renewed interest to use a magnetic resonance imaging (MRI) technique utilizing spin locking radiofrequency (RF) pulses, called T1ρMRI. The spin locking RF pulse creates sensitivity to some mechanisms of nuclear relaxation such as1H exchange between water and amide, amine and hydroxyl functional groups in molecules; consequently, there is the potential to non-invasively, and without exogenous contrast agents, obtain important molecular information from diseased myocardial tissue. The purpose of this article is to review and critically examine the recent published literature in the field related to T1ρMRI of myocardial disease.
authors.affiliation: Cardiovascular Division, Department of Medicine, Perelman School of Medicine, Hospital of the University of Pennsylvania, 9022 Gates, 3400 Spruce Street, Philadelphia, PA, USA.
authors.forename: Yuchi
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
authors.forename: Timo
authors.initials: T
authors.lastname: Liimatainen
authors.affiliation: Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Smilow Center for Translational Research, 3400 Civic Center Blvd, Bldg 421, 7th floor, Rm 103, Philadelphia, PA 19104, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Gorman
authors.affiliation: Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Smilow Center for Translational Research, 3400 Civic Center Blvd, Bldg 421, 7th floor, Rm 103, Philadelphia, PA 19104, USA.
authors.forename: Walter R T
authors.initials: WR
authors.lastname: Witschey
keywords: Heart disease; Ischemic; Magnetic resonance imaging; Non-ischemic; Spin lock radiofrequency pulse; T1ρ relaxation