title: Recent progress in the chemical synthesis of proteins.
abstract: A methodology for chemical protein synthesis by ligation chemistry has become increasingly practical and applied to the synthesis of various proteins and glycoproteins for their structural and functional analyses. This is largely due to the advances in the synthesis of peptide thioester as well as to the progress in the extension of the ligation chemistry to a non-cysteine site, which are briefly summarized in this review.
authors.affiliation: Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Osaka 565-0871, Japan. Electronic address: hojo@protein.osaka-u.ac.jp.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Hojo
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004952:Esters; D005449:Fluorenes / Q000737:chemistry; D011506:Proteins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C496789:9-fluorenylmethoxycarbonyl; D004952:Esters; D005449:Fluorenes; D011506:Proteins