title: A requiem to the nuclear matrix: from a controversial concept to 3D organization of the nucleus.
abstract: The first papers coining the term "nuclear matrix" were published 40 years ago. Here, we review the data obtained during the nuclear matrix studies and discuss the contribution of this controversial concept to our current understanding of nuclear architecture and three-dimensional organization of genome.
authors.affiliation: Institute of Gene Biology of the Russian Academy of Sciences, 119334, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Razin
authors.forename: O V
authors.initials: OV
authors.lastname: Iarovaia
authors.forename: Y S
authors.initials: YS
authors.lastname: Vassetzky
mesh_terms: D000818:Animals; D016678:Genome; D006801:Humans; D015530:Nuclear Matrix / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D011506:Proteins