title: Clinicopathological and immunohistochemical characterisation of gastric schwannomas in 29 cases.
abstract: Schwannomas are tumors arising from the nervous system that also occur infrequently in the gastrointestinal tract, most commonly in the stomach. This report characterizes 29 patients with benign or malignant gastric schwannomas. Surgical data and clinical follow-up information were available for 28 cases with a median postoperative duration of 57 months. Clinicopathological and immunohistochemical characteristics of benign and malignant schwannomas were analysed. Four cases (13.7%) were histologically diagnosed with malignant schwannoma. All tumors were positive for S-100 and CD56 proteins, displaying a diffuse staining pattern. Vimentin was expressed in 100% cases and all schwannomas were negative for smooth muscle actin, c-kit, and HMB-45. A significant difference was observed between the group of benign and malignant schwannomas as regards recurrences and metastasis after complete resection (P = 0.015). The survival time of patients with benign schwannomas was longer than the malignant group (P = 0.013), so gastric malignant schwannomas have a potential for recurrence and metastasis, with subsequently short survival. Complete resection with an attempt to remove all tumor tissue with negative margins is of paramount importance in the management of gastric schwannomas, particularly when they turn out to be malignant.
authors.affiliation: Department of General Surgery, Tenth People's Hospital of Shanghai, Tongji University, School of Medicine, Shanghai 200072, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of Surgery, Beijing Cancer Hospital, Peking University School of Oncology, Beijing 100036, China.
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Wu
authors.affiliation: Charité University Medicine, Department of General-, Visceral- and Vascular Surgery, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany.
authors.forename: Martin E
authors.initials: ME
authors.lastname: Kreis
authors.affiliation: Department of General Surgery, Tenth People's Hospital of Shanghai, Tongji University, School of Medicine, Shanghai 200072, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Pathology, Tenth People's Hospital of Shanghai, Tongji University, School of Medicine, Shanghai 200072, China.
authors.forename: Lijin
authors.initials: L
authors.lastname: Feng
authors.affiliation: Department of General Surgery, Tenth People's Hospital of Shanghai, Tongji University, School of Medicine, Shanghai 200072, China.
authors.forename: Chunqiu
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Tenth People's Hospital of Shanghai, Tongji University, School of Medicine, Shanghai 200072, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Surgery, Beijing Cancer Hospital, Peking University School of Oncology, Beijing 100036, China.
authors.forename: Zhaode
authors.initials: Z
authors.lastname: Bu
authors.affiliation: Department of Surgery, Beijing Cancer Hospital, Peking University School of Oncology, Beijing 100036, China.
authors.forename: Ziyu
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Surgery, Beijing Cancer Hospital, Peking University School of Oncology, Beijing 100036, China.
authors.forename: Jiafu
authors.initials: J
authors.lastname: Ji