title: Molecular characterization of the complete genome of falconid herpesvirus strain S-18.
abstract: Falconid herpesvirus type 1 (FaHV-1) is the causative agent of falcon inclusion body disease, an acute, highly contagious disease of raptors. The complete nucleotide sequence of the genome of FaHV-1 has been determined using Illumina MiSeq sequencing. The genome is 204,054 nucleotides in length and has a class E organization. The genome encodes approximately 130 putative protein-coding genes, of which 70 are orthologs of conserved alphaherpesvirus and Mardivirus proteins. Three FaHV-1 genes (UL3.5, UL44.5 and CIRC) were identified that encode protein homologues unique to Mardivirus and Varicellovirus. The genome also encodes homologues to the Mardivirus genes LORF2, LORF3, LORF4, LORF5, SORF3 and SORF4. An opal mutation resulting in premature termination was identified in the FaHV-1 UL43 gene. Phylogenetically, FaHV-1 resides in a monophyletic group with the other Mardiviruses but, along with anatid herpesvirus 1, represents a more distant divergence from the rest of the Mardivirus genus.
authors.affiliation: Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA. Electronic address: Stephen.Spatz@ars.usda.gov.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Spatz
authors.affiliation: BASE2BIO, 1945 Arlington Drive, Oshkosh, WI 54904, USA. Electronic address: jeremy@base2bio.com.
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Volkening
authors.affiliation: Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA.
authors.forename: Teresa A
authors.initials: TA
authors.lastname: Ross
mesh_terms: D000818:Animals; D001715:Bird Diseases / Q000821:virology; D016000:Cluster Analysis; D004279:DNA, Viral / Q000737:chemistry* / Q000235:genetics*; D023061:Gene Order; D016679:Genome, Viral; D006564:Herpesviridae / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010802:Phylogeny; D020304:Raptors; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid
chemical_list: D004279:DNA, Viral
keywords: Falcon; Falconid herpesvirus1; Genome; Inclusion body disease; Sequence