title: Synthesis, characterization, and in vitro studies of PLGA-PEG nanoparticles for oral insulin delivery.
abstract: Therapeutic proteins and peptides are corresponding to a major area of research in biotechnology companies and current pharmaceutical. Because of their natural instability, the enormous majority of these drugs require parentéral administration. Oral insulin delivery would be a highly attractive alternative process of administration, though it continues to be a mysterious target due to the enzymatic digestion of insulin and low levels of absorption from the gastrointestinal region. Hydrogel polymers can be considered as potential carriers for oral insulin delivery. In particular, a pH responsive hydrogel composed of PLGA-PEG has shown the ability to protect insulin from enzymes in the gastric environment and release in small intestines. However, this material has not shown similar potential for oral protein delivery of further model drugs. To date, the unique interaction between PLGA-PEG and insulin, as a potential drug for oral delivery, is not completely understood. The focus of this research is synthetization and characterization of hydrogels PLGA-PEG insulin nanoparticles and also pH sensitivity of insulin nanoparticles was investigated.
authors.affiliation: Department of Medicinal Chemistry and Drug Applied Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 51368, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Hosseininasab
authors.forename: Roghiyeh
authors.initials: R
authors.lastname: Pashaei-Asl
authors.forename: Amir Ahmad
authors.initials: AA
authors.lastname: Khandaghi
authors.forename: Hamid Tayefi
authors.initials: HT
authors.lastname: Nasrabadi
authors.forename: Kazem
authors.initials: K
authors.lastname: Nejati-Koshki
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Joo
authors.forename: Younes
authors.initials: Y
authors.lastname: Hanifehpour
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Davaran
mesh_terms: D000284:Administration, Oral; D003920:Diabetes Mellitus / Q000188:drug therapy; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000008:administration & dosage / Q000737:chemistry*; D019344:Lactic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D004337:Drug Carriers; D007328:Insulin; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid
keywords: PLGA-PEG insulin; oral delivery; pH sensitivity