title: Modifications of the homeostasis model assessment of insulin resistance index with age.
abstract: The aim of the study was to analyze the association between aging and insulin resistance estimated by the homeostasis model assessment of insulin resistance (HOMA-IR). This work involved two studies: (1) the Di@bet.es study is a cross-sectional study including 4,948 subjects, comprising a representative sample of the adult Spanish population; (2) the Pizarra study is a population-based cohort study undertaken in Pizarra (Spain), in which 1,051 subjects were evaluated at baseline and 714 completed the 6-year follow-up study. Study variables included a clinical and demographic structured survey, a lifestyle survey, a physical examination, and an oral glucose tolerance test in subjects without diabetes. In the Di@bet.es study overall, an increase occurred in blood glucose until the age of 50, after which it remained stable (data adjusted for gender, body mass index, abnormal glucose regulation [AGR]). The HOMA-IR increased significantly with age (p = 0.01), due to a higher prevalence of obesity (p < 0.0001) and AGR (p < 0.001). In non-obese subjects without AGR, HOMA-IR values were not modified with age (p = 0.30), but they were with body mass index (p < 0.001). In the Pizarra study, the HOMA-IR was significantly lower after 6-year follow-up in the whole study population. Subjects with a HOMA-IR level higher than the 75th percentile at baseline were more likely to develop diabetes (OR 2.2, 95 % CI 1.2-3.9; p = 0.007) than subjects with a lower HOMA-IR. We concluded that age per se did not increase HOMA-IR levels, changes that might be related to higher rates of obesity and AGR in older subjects. The HOMA-IR was associated with an increased risk of developing type 2 diabetes 6 years later.
authors.affiliation: Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain.
authors.forename: Federico
authors.initials: F
authors.lastname: Soriguer
authors.forename: Natalia
authors.initials: N
authors.lastname: Colomo
authors.forename: Sergio
authors.initials: S
authors.lastname: Valdés
authors.forename: Alberto
authors.initials: A
authors.lastname: Goday
authors.forename: Elehazara
authors.initials: E
authors.lastname: Rubio-Martín
authors.forename: Isabel
authors.initials: I
authors.lastname: Esteva
authors.forename: Luis
authors.initials: L
authors.lastname: Castaño
authors.forename: María Soledad
authors.initials: MS
authors.lastname: Ruiz de Adana
authors.forename: Sonsoles
authors.initials: S
authors.lastname: Morcillo
authors.forename: Alfonso
authors.initials: A
authors.lastname: Calle
authors.forename: Eduardo
authors.initials: E
authors.lastname: García-Fuentes
authors.forename: Miguel
authors.initials: M
authors.lastname: Catalá
authors.forename: Carolina
authors.initials: C
authors.lastname: Gutiérrez-Repiso
authors.forename: Elias
authors.initials: E
authors.lastname: Delgado
authors.forename: Ramón
authors.initials: R
authors.lastname: Gomis
authors.forename: Emilio
authors.initials: E
authors.lastname: Ortega
authors.forename: Gemma
authors.initials: G
authors.lastname: Rojo-Martínez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005260:Female; D006305:Health Status Indicators; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D009765:Obesity / Q000453:epidemiology; D015995:Prevalence; D013030:Spain / Q000453:epidemiology; D055815:Young Adult