title: In vitro examination of surface light scattering in hydrophobic acrylic intraocular lenses.
abstract: OBJECTIVE
  To evaluate laboratory models using accelerated aging to assess surface light scattering in hydrophobic acrylic intraocular lenses (IOLs).
  
  
  METHODS
  Miyata Eye Hospital, Miyazaki, Japan.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Acrysof SA60AT IOLs manufactured before optimization of the IOL production process (non-optimized IOLs) and Acrysof SN60WF IOLs that were manufactured after optimization of the production process (optimized IOLs) were examined. After the IOLs were accelerated aged corresponding to 0, 3, 5, 10, 15, and 20 years, surface light scattering was measured with a Scheimpflug camera. Formation of water aggregates below the IOL surface was observed with cryogenic focused ion-beam scanning electron microscopy.
  
  
  RESULTS
  In the non-optimized IOLs, surface light scattering increased with aging (P<.001, R2=0.87). There was no significant increase in surface light scattering in the optimized IOLs. An increase in water aggregates with sizes of nanometer order was observed in the aged non-optimized IOLs.
  
  
  CONCLUSIONS
  An in vitro model using accelerated aging was effective for examining the incidence of surface light scattering. The laboratory results showed suppression of surface light scattering in the IOL manufactured with the optimized process.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From Miyata Eye Hospital, Miyakonojo, Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Minami
authors.affiliation: From Miyata Eye Hospital, Miyakonojo, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Maruyama
authors.affiliation: From Miyata Eye Hospital, Miyakonojo, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Honbo
authors.affiliation: From Miyata Eye Hospital, Miyakonojo, Japan.
authors.forename: Jiro
authors.initials: J
authors.lastname: Matsunaga
authors.affiliation: From Miyata Eye Hospital, Miyakonojo, Japan. Electronic address: kmiyata@miyata-med.ne.jp.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Miyata
mesh_terms: D000180:Acrylic Resins; D057927:Hydrophobic and Hydrophilic Interactions; D066298:In Vitro Techniques; D007910:Lenses, Intraocular; D008027:Light; D008962:Models, Theoretical; D012542:Scattering, Radiation; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins