title: [Inhibitory effects of high mobility group chromosomal protein N2 on human tongue carcinoma transplanted in nude mice].
abstract: OBJECTIVE
  To evaluate the inhibitory effect of high mobility group chromosomal protein N2 (HMGN2) on human tongue carcinoma tumor in nude mice.
  
  
  METHODS
  A transplantation tumor model in nude mice was constructed by injecting Tca8113 cells. After a week, negative control groups, masculine control groups, and HMGN2 groups were established. Cell culture of the three groups were separately injected with washing buffer II, cis-dichlorodiamineplatinum (DDP), and HMGN2 protein. The tumors were moved after four treatments, and then analyzed by hematoxylin-eosin (HE) staining.
  
  
  RESULTS
  A transplanted tumor model was established successfully. The volumes of HMGN2 groups and masculine control groups were smaller than those of the negative groups. Mouse weight did not differ among the three groups. Average tumor weight of the negative group was (0.38 +/- 0.19)g, that of the HMGN2 group was (0.21 +/- 0.15)g, and that of the DDP group was (0.23 +/- 0.16)g. These factors indicated no statistically significant difference among the three groups. The tumor inhibitory rate of HMGN2 group was 45.71%, and that of the positive group was 39.44%. Based on evaluation by naked eye, the tumor in the negative group was larger than that in other groups. In addition, cell necrosis was observed during HE staining.
  
  
  CONCLUSIONS
  HMGN2 could significantly inhibit growth of the transplanted tumor in nude mice.
authors.forename: Xiqian
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Dong
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
authors.forename: Sixiu
authors.initials: S
authors.lastname: Chen
authors.forename: Yun
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000818:Animals; D002277:Carcinoma; D045744:Cell Line, Tumor; D006609:High Mobility Group Proteins; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014062:Tongue Neoplasms
chemical_list: D006609:High Mobility Group Proteins