title: Heart failure and obesity in adults: pathophysiology, clinical manifestations and management.
abstract: Obesity is both a risk factor and a direct cause of heart failure (HF) in adults. Severe obesity produces hemodynamic alterations that predispose to changes in left ventricular morphology and function, which, over time, may lend to the development of HF (obesity cardiomyopathy). Certain neurohormonal and metabolic abnormalities as well as cardiovascular co-morbidities may facilitate this process. Substantial purposeful weight loss is capable of reversing most of the alterations in cardiac performance and morphology and may improve functional capacity and quality of life in patents with obesity cardiomyopathy.
authors.affiliation: University-Columbia Division of Cardiovascular Medicine, University of Missouri Health Sciences Center, Room CE-306, 5 Hospital Drive, Columbia, MO, 65212, USA, alpertm@health.missouri.edu.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Alpert
authors.forename: Harsh
authors.initials: H
authors.lastname: Agrawal
authors.forename: Kul
authors.initials: K
authors.lastname: Aggarwal
authors.forename: Senthil A
authors.initials: SA
authors.lastname: Kumar
authors.forename: Arun
authors.initials: A
authors.lastname: Kumar
mesh_terms: D006333:Heart Failure / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology; D009765:Obesity / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000209:etiology; D015431:Weight Loss
chemical_list: D018377:Neurotransmitter Agents