title: Synthesis of steroidal and nonsteroidal vicinal heterocyclic alcohols, N-(1-cycloalkenyl)heterocycles and their antibacterial studies.
abstract: A solvent free steroidal and nonsteroidal epoxide ring opening reaction by nitrogen containing heterocycles under microwave irradiation is described. Some of the epoxide ring opening compounds were converted to their corresponding N-(1-cycloalkenyl)heterocycles via an acid catalyzed dehydration reaction. The antimicrobial activities of the epoxide ring opening compounds and N-(1-cycloalkenyl)heterocyclic compounds were tested by agar diffusion assay. Compounds 6, 9-12, 24 and 27 showed moderate inhibition against the growth of pathogenic bacteria Escherichia coli, Pseudomonas syringae, Bacillus subtilis, Proteus vulgaris and Staphylococcus aureus.
authors.affiliation: Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India.
authors.forename: Pallabi
authors.initials: P
authors.lastname: Saikia
authors.affiliation: Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India.
authors.forename: Partha Pratim
authors.initials: PP
authors.lastname: Kaishap
authors.affiliation: Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India.
authors.forename: Jonalee
authors.initials: J
authors.lastname: Goswami
authors.affiliation: Biotechnology Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Singh
authors.affiliation: Biotechnology Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India.
authors.forename: Hari Prasanna
authors.initials: HP
authors.lastname: Deka Boruah
authors.affiliation: Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India. Electronic address: skgogoi1@gmail.com.
authors.forename: Sanjib
authors.initials: S
authors.lastname: Gogoi
authors.affiliation: Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India. Electronic address: rc_boruah@yahoo.co.in.
authors.forename: Romesh C
authors.initials: RC
authors.lastname: Boruah
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D066244:Proton Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013256:Steroids / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000438:Alcohols; D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; D013256:Steroids
keywords: Antimicrobial; Epoxide; Heterosteroid; Microwave; N-(1-Cycloalkenyl)heterocycle