title: Ovarian metastasis of clear cell renal cell carcinoma: A case report.
abstract: We report on a 61-year-old woman with a history of right-sided nephrectomy for clear cell renal cell carcinoma (RCC) occurring 21 years ago; she currently presented with a bilateral ovarian tumour. Histologically, the tumour of both ovaries was clear cell carcinoma. Immunohistochemically, the tumour cells were positive for vimentin, RCC marker, epithelial membrane antigen, cytokeratin AE1/3 and CD10. Cytokeratin 7, CA125, HMWCK, estrogen and progesterone receptors were all negative. Based on the morphology and immunophenotype of the tumour, we established a diagnosis of late metastasis of RCC in the ovaries. A postoperative abdominal computed tomography scan, however, revealed a tumour mass solely in the left kidney, which had not been visible in the preoperative ultrasound. The patient underwent nephron-sparing surgery and a biopsy showed the tumour to be clear cell RCC. Metastasis of RCC to the ovaries is rare, and to the best of our knowledge, only 24 cases have been reported to date. However, due to the different treatments and prognosis, the distinction between a primary ovarian tumour and metastasis of RCC is important.
authors.affiliation: Institute of Pathology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic;
authors.forename: Lenka
authors.initials: L
authors.lastname: Bauerová
authors.affiliation: Institute of Pathology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic;
authors.forename: Pavel
authors.initials: P
authors.lastname: Dundr
authors.affiliation: Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic;
authors.forename: Daniela
authors.initials: D
authors.lastname: Fischerová
authors.affiliation: Department of Urology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic;
authors.forename: Michael
authors.initials: M
authors.lastname: Pešl
authors.affiliation: Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic;
authors.forename: Michal
authors.initials: M
authors.lastname: Zikán
authors.affiliation: Department of Radiology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: Andrea
authors.initials: A
authors.lastname: Burgetová