title: Low-grade gliomas.
abstract: Low-grade gliomas (LGGs) are a diverse group of primary brain tumors that often arise in young, otherwise healthy patients and generally have an indolent course with longer-term survival in comparison with high-grade gliomas. Treatment options include observation, surgery, radiation, chemotherapy, or a combined approach, and management is individualized based on tumor location, histology, molecular profile, and patient characteristics. Moreover, in this type of brain tumor with a relatively good prognosis and prolonged survival, the potential benefits of treatment must be carefully weighed against potential treatment-related risks. We review in this article current management strategies for LGG, including surgery, radiotherapy, and chemotherapy. In addition, the importance of profiling the genetic and molecular properties of LGGs in the development of targeted anticancer therapies is also reviewed. Finally, given the prevalence of these tumors in otherwise healthy young patients, the impact of treatment on neurocognitive function and quality of life is also evaluated.
authors.affiliation: Departments of Neurology, Neurosurgery, and Radiation Oncology, and Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Forst
authors.forename: Brian V
authors.initials: BV
authors.lastname: Nahed
authors.forename: Jay S
authors.initials: JS
authors.lastname: Loeffler
authors.forename: Tracy T
authors.initials: TT
authors.lastname: Batchelor
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D005910:Glioma / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology / Q000628:therapy; D006801:Humans; D011859:Radiography; D016896:Treatment Outcome; D055815:Young Adult
keywords: Astrocytoma; Glioma; Oligodendroglioma; Radiation; Surgery