title: Streptococcus suis infection: an emerging/reemerging challenge of bacterial infectious diseases?
abstract: Streptococcus suis (S. suis) is a family of pathogenic gram-positive bacterial strains that represents a primary health problem in the swine industry worldwide. S. suis is also an emerging zoonotic pathogen that causes severe human infections clinically featuring with varied diseases/syndromes (such as meningitis, septicemia, and arthritis). Over the past few decades, continued efforts have made significant progress toward better understanding this zoonotic infectious entity, contributing in part to the elucidation of the molecular mechanism underlying its high pathogenicity. This review is aimed at presenting an updated overview of this pathogen from the perspective of molecular epidemiology, clinical diagnosis and typing, virulence mechanism, and protective antigens contributing to its zoonosis.
authors.affiliation: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases & State Key Laboratory for Diagnosis and Treatment of Infectious Disease; First Affiliated Hospital; Zhejiang University School of Medicine; Hangzhou, Zhejiang, PR China; Department of Medical Microbiology and Parasitology; Zhejiang University School of Medicine; Hangzhou, Zhejiang, PR China.
authors.forename: Youjun
authors.initials: Y
authors.lastname: Feng
authors.affiliation: University of Illinois at Urbana-Champaign (UIUC); Urbana, IL USA.
authors.forename: Huimin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Veterinary Microbiology and Preventive Medicine; Iowa State University; Ames, IA USA.
authors.forename: Zuowei
authors.initials: Z
authors.lastname: Wu
authors.affiliation: College of Life Sciences; Fujian Agriculture and Forestry University; Fuzhou, Fujian, PR China.
authors.forename: Shihua
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Epidemiology; Research Institute for Medicine of Nanjing Command; Nanjing, Jiangsu, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Cao
authors.affiliation: Department of Epidemiology; Research Institute for Medicine of Nanjing Command; Nanjing, Jiangsu, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Epidemiology; Research Institute for Medicine of Nanjing Command; Nanjing, Jiangsu, PR China.
authors.forename: Changjun
authors.initials: C
authors.lastname: Wang
mesh_terms: D000818:Animals; D021821:Communicable Diseases, Emerging / Q000382:microbiology* / Q000635:transmission; D006801:Humans; D013290:Streptococcal Infections / Q000382:microbiology* / Q000635:transmission / Q000662:veterinary*; D017011:Streptococcus suis / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D015047:Zoonoses / Q000382:microbiology* / Q000635:transmission
keywords: Streptococcus suis; pathogenesis; zoonosis