title: Anti-cancer therapeutic potential of quinazoline based small molecules via global upregulation of miRNAs.
abstract: Three quinazoline based small molecules showed global upregulation of miRNA expression with a selective enrichment of tumor suppressor miRNAs. The target genes of the upregulated miRNAs were predicted to be enriched for apoptotic pathways. Apoptotic induction following treatment with quinazoline compounds was confirmed by in cellulo studies. Thus, these small molecules having the core structural moiety (2,4-diphenyl-quinazoline) can be used as scaffolds to design activators of miRNA expression paving the way for novel anti-cancer drugs.
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi-110001, India.
authors.forename: Smita
authors.initials: S
authors.lastname: Nahar
authors.forename: Debojit
authors.initials: D
authors.lastname: Bose
authors.forename: Sumit
authors.initials: S
authors.lastname: Kumar Panja
authors.forename: Satyen
authors.initials: S
authors.lastname: Saha
authors.forename: Souvik
authors.initials: S
authors.lastname: Maiti
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D020869:Gene Expression Profiling; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D011799:Quinazolines / Q000737:chemistry / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D035683:MicroRNAs; D011799:Quinazolines