title: Evaluation of granulocyte colony-stimulating factor effects on treatment-resistant thin endometrium in women undergoing in vitro fertilization.
abstract: The aim of the study was to assess the granulocyte colony-stimulating factor (G-CSF) effects on unresponsive thin (<7 mm) endometrium in women undergoing in vitro fertilization (IVF). We included thirty-seven subjects who had thin unresponsive endometrium on the day of triggering ovulation. These patients also failed to achieve an adequate endometrial thickness in at least one of their previous IVF cycles. In all the subjects at the time of infusion of G-CSF, endometrial thickness was 6,74 ± 1,75 mm, and, after infusion, it increased significantly to 8,42 ± 1,73 mm. When we divided the group into two subgroups according to whether the examined women conceived, we showed that the endometrium expanded significantly from 6,86 ± 1,65 to 8,80 ± 1,14 mm in the first group (who conceived) and from 6,71 ± 1,80 to 8,33 ± 1,85 mm in the second, respectively. There were no significant differences between the two subgroups in respect to the endometrial thickness both before and after G-CSF infusion. The clinical pregnancy rate was 18,9%. We concluded that the infusion of G-CSF leads to the improvement of endometrium thickness after 72 hours.
authors.affiliation: INVICTA Fertility and Reproductive Center, 00-019 Warszawa, Poland.
authors.forename: Michał
authors.identifier: 0000-0002-0222-7909
authors.initials: M
authors.lastname: Kunicki
authors.affiliation: Department of Obstetrics and Gynecological Nursing, Faculty of Health Sciences, Medical University of Gdansk, 80-952 Gdańsk, Poland ; Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Varmia and Masuria, 10-561 Olsztyn, Poland ; INVICTA Fertility and Reproductive Center, 80-850 Gdańsk, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Łukaszuk
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-747 Olsztyn, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Woclawek-Potocka
authors.affiliation: INVICTA Fertility and Reproductive Center, 80-850 Gdańsk, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Liss
authors.affiliation: INVICTA Fertility and Reproductive Center, 80-850 Gdańsk, Poland.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Kulwikowska
authors.affiliation: INVICTA Fertility and Reproductive Center, 80-850 Gdańsk, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Szczyptańska
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology*; D005260:Female; D005307:Fertilization in Vitro; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D011247:Pregnancy
chemical_list: D016179:Granulocyte Colony-Stimulating Factor