title: Factors associated with recurrence of cervical intraepithelial neoplasia 2+ after treatment among HIV-infected women in Western Kenya.
abstract: HIV-infected women are at increased risk for recurrence of cervical dysplasia after treatment. Short-term recurrence rates may reflect treatment efficacy and therefore impact screening protocols and follow-up planning. We conducted a prospective study of 297 HIV-infected women undergoing loop electrosurgical excision procedure for cervical intraepithelial neoplasia 2+ (CIN2+) in an HIV clinic in Kisumu, Kenya. By 6 months after the procedure, 20 (7.1%) of women had recurrent CIN2+. Recurrence was significantly associated with CD4 nadir but not with highly active antiretroviral therapy use. Longer-term follow-up of this cohort will illustrate the potential impact of highly active antiretroviral therapy and immune status on CIN2/3 disease recurrence.
authors.affiliation: *Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA; †Department of Epidemiology, University of California, Berkeley, CA; ‡Kenya Medical Research Institute, Nairobi, Kenya; and §.
authors.forename: Megan J
authors.initials: MJ
authors.lastname: Huchko
authors.forename: Hannah
authors.initials: H
authors.lastname: Leslie
authors.forename: May
authors.initials: M
authors.lastname: Maloba
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Bukusi
authors.forename: Craig R
authors.initials: CR
authors.lastname: Cohen
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000453:epidemiology* / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000453:epidemiology* / Q000601:surgery