title: [Use of fish oil lipid emulsions in hospitalized patients under 18 years old with abnormal results in liver tests associated with total parental nutrition].
abstract: BACKGROUND
  Prolonged Total Parental Nutrition (TPN) is associated with life-threatening complications in the pediatric population, being cholestasis one of the most important ones. The source of fatty acids, the amount of phytosterols and the dose of lipids in the nutritional support, have been linked to the development of this complication.
  
  
  OBJECTIVE
  To describe the behavior of liver function tests in pediatric patients with TPN where lipid based omega 3 fatty acids (OmegavenR) were used.
  
  
  METHODS
  A retrospective research was made in a population of children under 18 years old where omega 3 fatty acids were used for a minimum of 8 days. Patients were initially classified into two groups: cholestasis and abnormal liver tests. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), direct bilirubin (DB) gamma glutamyl transferase (GGT) and alkaline phosphatase (AP) before and after treatment with OmegavenR was evaluated.
  
  
  RESULTS
  33 patients met the inclusion criteria. At the end of treatment with OmegavenR, 82.4% of patients who initially presented cholestasis showed resolution or improvement. The group of patients with abnormal liver tests 18.8% progressed to cholestasis.
  
  
  CONCLUSIONS
  Our study suggests that the use of OmegavenR in pediatric patients with TPN and DB ≥ 2 mg/dL, seem to reverse or improve cholestasis while in patients with abnormal liver tests we still don't have clear effect.
authors.affiliation: Nutricionista clínica. Magíster en epidemiología. Grupo de Soporte Nutricional Pediátrico. Hospital Pablo Tobón Uribe. Colombia. agiraldov85@yahoo.com.
authors.forename: Adriana
authors.initials: A
authors.lastname: Giraldo Villa
authors.affiliation: Nutricionista clínica. Magíster en nutrición infantil. Grupo de Soporte Nutricional Pediátrico. Hospital Pablo Tobón Uribe. Colombia.
authors.forename: Catherine
authors.initials: C
authors.lastname: Henao Roldan
authors.affiliation: Pediatra subespecialista en cuidado intensivo. Grupo de Soporte Nutricional Pediátrico. Hospital Pablo Tobón Uribe. Colombia.
authors.forename: Fanny
authors.initials: F
authors.lastname: García Loboguerrero
authors.affiliation: Enfermera especialista en cuidado al niño en estado crítico de salud. Grupo de Soporte Nutricional Pediátrico. Hospital Pablo Tobón Uribe. Colombia.
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Martínez Volkmar
authors.affiliation: Pediatra Gastroenteróloga. Grupo de Soporte Nutricional Pediátrico. Hospital Pablo Tobón Uribe. Colombia.
authors.forename: Mónica María
authors.initials: MM
authors.lastname: Contreras Ramírez
authors.affiliation: Pediatra Gastroenteróloga y nutrióloga. Grupo de Soporte Nutricional Pediátrico. Hospital Pablo Tobón Uribe. Colombia.
authors.forename: Patricia
authors.initials: P
authors.lastname: Ruiz Navas
mesh_terms: D002648:Child; D002675:Child, Preschool; D002779:Cholestasis / Q000178:diet therapy; D015331:Cohort Studies; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008111:Liver Function Tests; D008297:Male; D010289:Parenteral Nutrition, Total; D012189:Retrospective Studies; D012778:Short Bowel Syndrome / Q000628:therapy
chemical_list: D005217:Fat Emulsions, Intravenous; D015525:Fatty Acids, Omega-3; D005395:Fish Oils