title: Protein S-nitrosylation in preconditioning and postconditioning.
abstract: The coronary artery disease is a leading cause of death and morbidity worldwide. This disease has a complex pathophysiology that includes multiple mechanisms. Among these is the oxidative/nitrosative stress. Paradoxically, oxidative/nitrosative signaling plays a major role in cardioprotection against ischemia/reperfusion injury. In this context, the gas transmitter nitric oxide may act through several mechanisms, such as guanylyl cyclase activation and via S-nitrosylation of proteins. The latter is a covalent modification of a protein cysteine thiol by a nitric oxide-group that generates an S-nitrosothiol. Here, we report data showing that nitric oxide and S-nitrosylation of proteins play a pivotal role not only in preconditioning but also in postconditioning cardioprotection.
authors.forename: Claudia
authors.initials: C
authors.lastname: Penna
authors.forename: Carmelina
authors.initials: C
authors.lastname: Angotti
authors.forename: Pasquale
authors.initials: P
authors.lastname: Pagliaro
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000378:metabolism* / Q000473:pathology; D019157:Ischemic Preconditioning, Myocardial; D009569:Nitric Oxide / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
chemical_list: D009569:Nitric Oxide