title: Manipulating mitochondrial genomes in the clinic: playing by different rules.
abstract: Recently, several publications have surfaced describing methods to manipulate mitochondrial genomes in tissues and embryos. With them, a somewhat sensationalistic uproar about the generation of children with 'three parents' has dominated the discussion in the lay media. It is important that society understands the singularities of mitochondrial genetics to judge these procedures in a rational light, so that this ongoing discussion does not preclude the helping of patients and families harboring mutated mitochondrial genomes.
authors.affiliation: University of Miami Miller School of Medicine, Department of Neurology and Cell Biology, 1420 NW 9th Avenue, Rm 229, Miami, FL 33136, USA. Electronic address: cmoraes@med.miami.edu.
authors.forename: Carlos T
authors.initials: CT
authors.lastname: Moraes
authors.affiliation: University of Miami Miller School of Medicine, Department of Neurology and Cell Biology, 1420 NW 9th Avenue, Rm 229, Miami, FL 33136, USA.
authors.forename: Sandra R
authors.initials: SR
authors.lastname: Bacman
authors.affiliation: University of Miami Miller School of Medicine, Department of Neurology and Cell Biology, 1420 NW 9th Avenue, Rm 229, Miami, FL 33136, USA.
authors.forename: Sion L
authors.initials: SL
authors.lastname: Williams
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics*; D019143:Evolution, Molecular; D054629:Genome, Mitochondrial / Q000235:genetics*; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D028701:Patient Rights
chemical_list: D004272:DNA, Mitochondrial