title: Altered frontal EEG asymmetry in obsessive-compulsive disorder.
abstract: Hemispheric topography of alpha band power in the electroencephalogram has been linked to approach/avoidance motivation and may index the risk for anxiety disorders and depression. We quantified lower alpha band power (8-10 Hz) in 20 patients with obsessive-compulsive disorder (OCD) and 20 matched healthy controls during blocks of rest and presentation of neutral, aversive, and OCD-related pictures. Compared to the control group, OCD patients showed altered asymmetry, with frontal alpha power in the 8-10 Hz band being more dominant in the left hemisphere across all conditions. This alteration was not observed over parietal areas, and also did not show in the upper alpha, and the theta and beta bands. This change in hemispheric topography of lower alpha band power supports the hypothesis of relatively increased avoidance motivation in OCD. Altered asymmetry appears to be traitlike in OCD, suggesting a link to depressive disorders.
authors.affiliation: Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Ischebeck
authors.forename: Tanja
authors.initials: T
authors.lastname: Endrass
authors.forename: Daniela
authors.initials: D
authors.lastname: Simon
authors.forename: Norbert
authors.initials: N
authors.lastname: Kathmann
mesh_terms: D000328:Adult; D000513:Alpha Rhythm; D004569:Electroencephalography; D004644:Emotions; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D007839:Functional Laterality; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D010775:Photic Stimulation; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors
keywords: Brain asymmetry; Electroencephalography; Emotion; Obsessive-compulsive disorder