title: Xanthone glycosides from Swertia bimaculata with α-glucosidase inhibitory activity.
abstract: Seven new xanthone glycosides (1-7) were isolated from the n-butanol extract of Swertia bimaculata, together with six known compounds (8-13). Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. All the compounds were evaluated for their α-glucosidase inhibitory activities in vitro, and compounds 3, 4, and 7 exhibited significant activities to inhibit α-glucosidase. Meanwhile the effects of different substitutions on the α-glucosidase inhibitory activity of xanthone glycosides from S. bimaculata are also discussed.
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Yao-Dong
authors.initials: YD
authors.lastname: Yue
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Zhang
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Zhao-Xia
authors.initials: ZX
authors.lastname: Liu
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Qiu-Xia
authors.initials: QX
authors.lastname: Min
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Luo-Sheng
authors.initials: LS
authors.lastname: Wan
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Yong-Long
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Zuo-Qi
authors.initials: ZQ
authors.lastname: Xiao
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Jia-Chun
authors.initials: JC
authors.lastname: Chen
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D029967:Swertia / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: C000593455:1-O-(beta-D-xylopyranosyl-(1-4)-beta-D-glucopyranosyl)-3,8-dihydroxy-4,5-dimethoxyxanthone; C000593453:1-O-(beta-D-xylopyranosyl-(1-6)-beta-D-glucopyranosyl)-8-hydroxy-3,4,5-trimethoxyxanthone; C000593454:8-O-(beta-D-xylopyranosyl-(1-6)-beta-D-glucopyranosyl)-1-hydroxy-3,4,5-trimethoxyxanthone; D004791:Enzyme Inhibitors; D006027:Glycosides; D010936:Plant Extracts; D044004:Xanthones; D000520:alpha-Glucosidases