title: Significant mitral regurgitation left untreated at the time of aortic valve replacement: a comprehensive review of a frequent entity in the transcatheter aortic valve replacement era.
abstract: Significant mitral regurgitation (MR) is frequent in patients with severe aortic stenosis (AS). In these cases, concomitant mitral valve repair or replacement is usually performed at the time of surgical aortic valve replacement (SAVR). Transcatheter aortic valve replacement (TAVR) has recently been considered as an alternative for patients at high or prohibitive surgical risk. However, concomitant significant MR in this setting is typically left untreated. Moderate to severe MR after aortic valve replacement is therefore a relevant entity in the TAVR era. The purpose of this review is to present the current knowledge on the clinical impact and post-procedural evolution of concomitant significant MR in patients with severe AS who have undergone aortic valve replacement (SAVR and TAVR). This information could contribute to improving both the clinical decision-making process in and management of this challenging group of patients.
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada; Cardiovascular Institute, Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Nombela-Franco
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Henrique Barbosa
authors.initials: HB
authors.lastname: Ribeiro
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Marina
authors.initials: M
authors.lastname: Urena
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Allende
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Amat-Santos
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: DeLarochellière
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Dumont
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Doyle
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Hugo
authors.initials: H
authors.lastname: DeLarochellière
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Jerôme
authors.initials: J
authors.lastname: Laflamme
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Louis
authors.initials: L
authors.lastname: Laflamme
authors.affiliation: Cardiovascular Institute, Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain.
authors.forename: Eulogio
authors.initials: E
authors.lastname: García
authors.affiliation: Cardiovascular Institute, Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Macaya
authors.affiliation: Cardiovascular Institute, Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Jiménez-Quevedo
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Côté
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Bergeron
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Beaudoin
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Pibarot
authors.affiliation: Quebec Heart & Lung Institute, Quebec City, Quebec, Canada. Electronic address: josep.rodes@criucpq.ulaval.ca.
authors.forename: Josep
authors.initials: J
authors.lastname: Rodés-Cabau
mesh_terms: D000818:Animals; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000601:surgery*; D006328:Cardiac Catheterization / Q000379:methods / Q000639:trends; D019918:Heart Valve Prosthesis Implantation / Q000379:methods / Q000639:trends; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography
keywords: aortic stenosis; mitral regurgitation; percutaneous therapy; transcatheter aortic valve implantation