title: Wound healing activity of Origanum vulgare engineered titanium dioxide nanoparticles in Wistar Albino rats.
abstract: The titanium dioxide nanoparticles (TiO2·NPs) were synthesized utilizing Origanum vulgare under room temperature. The green synthesized TiO2 NPs excitation was confirmed using UV-Vis spectrophotometer at 320 nm. Scanning electron microscopy analysis showed TiO2·NPs are spherical in shape and connected with one another. Dynamic light scattering analysis results specified high stability in nanoparticles, with an average particle size of 341 nm. Fourier transform infrared spectroscopy peaks revealed the presence of bioactive functional groups in Origanum vulgare aqueous leaf extract much needed for the TiO2·NPs formation. X-ray diffraction spectra showed the TiO2·NPs are amorphous in nature. Furthermore, the green synthesized TiO2·NPs wound healing activity was examined in the excision wound model by measuring wound closure, histopathology and protein profiling, revealed significant wound healing activity in Albino rats. In conclusion, our results bared TiO2·NPs have delivered a novel therapeutic route for wound treatment in clinical practice.
authors.affiliation: Department of Biochemistry, School of Life Science, Bharathidasan University, Tiruchirappalli, 620 024, Tamilnadu, India.
authors.forename: Renu
authors.initials: R
authors.lastname: Sankar
authors.forename: Ravishankar
authors.initials: R
authors.lastname: Dhivya
authors.forename: Kanchi Subramanian
authors.initials: KS
authors.lastname: Shivashangari
authors.forename: Vilwanathan
authors.initials: V
authors.lastname: Ravikumar
mesh_terms: D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D006863:Hydrogen-Ion Concentration; D008027:Light; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D031341:Origanum; D010316:Particle Size; D018515:Plant Leaves / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012542:Scattering, Radiation; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods*; D014025:Titanium / Q000737:chemistry*; D014945:Wound Healing; D014961:X-Ray Diffraction
chemical_list: C009495:titanium dioxide; D014025:Titanium