title: Vortioxetine for the treatment of depression.
abstract: OBJECTIVE
  To evaluate the clinical literature and potential clinical role of vortioxetine (Brintellix) for the treatment of major depressive disorder (MDD).
  
  
  METHODS
  A MEDLINE search (1966-February 2014) was conducted using the search terms vortioxetine, Lu AA21004, and depression. Bibliographies of all articles retrieved were also reviewed. All references included were published between 1999 and 2014.
  
  
  METHODS
  All studies that included humans and were published in English, with data describing vortioxetine for the treatment of MDD, were reviewed.
  
  
  RESULTS
  Vortioxetine is a novel multimodal antidepressant agent, which inhibits the 5-HT transporter protein, acts as a 5-HT3 antagonist, 5-HT1A receptor agonist, 5-HT7 receptor antagonist, and a partial agonist of the 5-HT1B receptor. It has been studied in 10 short-term (6-8 weeks), 1 relapse-prevention, and 3 long-term extension trials. Vortioxetine demonstrated efficacy in reducing Montgomery-Asberg Depression Rating Scale or Hamilton Rating Scale for Depression scores in 6 of the short-term trials. The proportion of individuals who responded to treatment and achieved remission increased over time in all 3 long-term trials. The most common adverse effects, consistently reported by >10% of individuals in the clinical trials include nausea and headache.
  
  
  CONCLUSIONS
  Vortioxetine is an effective agent for the treatment of MDD, but it does not have any clear advantages over other available treatment options.
authors.affiliation: St. Louis College of Pharmacy, St. Louis, MO, USA.
authors.forename: Erica F
authors.initials: EF
authors.lastname: Pearce
authors.forename: Julie A
authors.initials: JA
authors.lastname: Murphy
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D010879:Piperazines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D018490:Serotonin Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D013440:Sulfides / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000078784:Vortioxetine
chemical_list: D000928:Antidepressive Agents; D010879:Piperazines; D018490:Serotonin Agents; D013440:Sulfides; D000078784:Vortioxetine
keywords: Lu AA21004; depression; major depressive disorder; vortioxetine