title: Naphthalene-hydrophobized β-1,3-glucan nanogel for doxorubicin delivery to immunocytes.
abstract: A water soluble β-1,3-glucan schizophyllan (SPG) can be recognized by an immunocyte receptor called dectin-1. When we introduced naphthalene into the side chain of SPG (nSPG), it formed nanogel by physical cross-link and gained capability to ingest hydrophobic compounds such as doxorubicin. Our in vitro assay revealed that this nanogel can be used as specific delivery of anti-cancer drugs to immunocytes.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu, Fukuoka 8080135, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Maeda
authors.affiliation: Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu, Fukuoka 8080135, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Mochizuki
authors.affiliation: Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu, Fukuoka 8080135, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sanada
authors.affiliation: Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu, Fukuoka 8080135, Japan. Electronic address: sakurai@kitakyu-u.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sakurai
mesh_terms: D000938:Antigen-Presenting Cells / Q000187:drug effects*; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008954:Models, Biological; D015394:Molecular Structure; D000080385:Nanogels; D009281:Naphthalenes / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D047071:beta-Glucans / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000080385:Nanogels; D009281:Naphthalenes; D047071:beta-Glucans; C413692:polyethylene glycol polyethyleneimine nanogel; C031721:naphthalene; D011092:Polyethylene Glycols; D004317:Doxorubicin; D011094:Polyethyleneimine; C033363:beta-1,3-glucan
keywords: Doxorubicin; Hydrophobic interaction; Macrophage; Nanogel; Schizophyllan