title: Multifaceted chitin/poly(lactic-co-glycolic) acid composite nanogels.
abstract: Cyto-compatible, 80nm sized chitin/PLGA composite nanogels (chit/PLGA-comp NGs) were prepared by regeneration method and characterized. The multifaceted chit/PLGA-comp NGs were surface modified with Au, Fe3O4, CdTe/ZnTe-QDs and umbelliferone, respectively. 185nm sized Au-chit/PLGA-comp NGs, 170nm sized QD-chit/PLGA-comp-NGs and 160nm sized Fe3O4-chit/PLGA-comp-NGs showed RF heating. The QD-chit/PLGA-comp-NGs and 180nm sized umb-chit/PLGA-comp-NGs were well uptaken by Escherichia coli, Staphylococcus aureus and Candida albicans. The chit/PLGA-comp NGs could be useful for microbial monitoring and RF application for cancer therapy. The preliminary data showed that multifaceted chit/PLGA-comp-NGs could be useful for hyperthermia for cancer treatment and microbial labelling and imaging.
authors.affiliation: Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Ponekkara, Kochi 682041, India.
authors.forename: N Sanoj
authors.initials: NS
authors.lastname: Rejinold
authors.affiliation: Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Ponekkara, Kochi 682041, India.
authors.forename: Raja
authors.initials: R
authors.lastname: Biswas
authors.affiliation: Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Ponekkara, Kochi 682041, India.
authors.forename: Gopi
authors.initials: G
authors.lastname: Chellan
authors.affiliation: Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Ponekkara, Kochi 682041, India. Electronic address: rjayakumar@aims.amrita.edu.
authors.forename: R
authors.initials: R
authors.lastname: Jayakumar
mesh_terms: D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D002686:Chitin / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D019344:Lactic Acid / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D053761:Nanocomposites / Q000008:administration & dosage / Q000737:chemistry; D000080385:Nanogels; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010316:Particle Size; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D011094:Polyethyleneimine / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D000080385:Nanogels; C413692:polyethylene glycol polyethyleneimine nanogel; D002686:Chitin; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; D011094:Polyethyleneimine
keywords: Chitin; Composite nanogels; Hyperthermia; Microbial and cellular imaging; PLGA