title: [Two cases of primary malignant melanoma of the larynx: a rare pathology].
abstract: BACKGROUND
  Primary malignant melanoma of the larynx is a very rare entity. There are less than sixty cases described in the literature. Through both cases, we describe and discuss the clinical management of melanoma of the larynx.
  
  
  METHODS
  Two men aged 80 and 61 years were supported for MPL. The tumor was revealed by persistent dysphonia for the first. For the second, it was a second melanoma of laryngeal location. In both cases it was performed a total laryngectomy extended to the first tracheal rings with bilateral lymphadenectomy associated with adjuvant radiotherapy.
  
  
  CONCLUSIONS
  Excision margins with oncological safety are necessary to except a curative surgery. Still controversial, the adjuvant radiotherapy seems to provide a benefit in terms of local control. The place of targeted therapies remains unclear. However, no prognostic factor is currently clearly identified for this disease.
  
  
  CONCLUSIONS
  Rare tumor, the MPL is associated with a very poor prognosis. Resective surgery followed by adjuvant radiotherapy is for us the treatment of choice.
authors.forename: B
authors.initials: B
authors.lastname: Chaput
authors.forename: G
authors.initials: G
authors.lastname: De Bonnecaze
authors.forename: S
authors.initials: S
authors.lastname: Vergez
authors.forename: I
authors.initials: I
authors.lastname: Garrido
authors.forename: J L
authors.initials: JL
authors.lastname: Grolleau
authors.forename: A
authors.initials: A
authors.lastname: Benlyazid
mesh_terms: D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D018450:Disease Progression; D055154:Dysphonia / Q000209:etiology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D007825:Laryngectomy; D008197:Lymph Node Excision; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D011379:Prognosis; D018714:Radiotherapy, Adjuvant