title: Development of intrinsically photoluminescent and photostable polylactones.
abstract: A method of introducing intrinsically photo luminescent properties to biodegradable polymer is introduced, exemplified by the synthesis of intrinsically photoluminescent polylactones that enable non-invasive monitoring and tracking of material degradation in vivo in realtime, as well as the formation of theranostic nanoparticles for cancer imaging and drug delivery.
authors.affiliation: Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Xie
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Weng
authors.forename: Ralph P
authors.initials: RP
authors.lastname: Mason
authors.forename: Liping
authors.initials: L
authors.lastname: Tang
authors.forename: Kytai T
authors.initials: KT
authors.lastname: Nguyen
authors.forename: Jer-Tsong
authors.initials: JT
authors.lastname: Hsieh
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001943:Breast Neoplasms / Q000175:diagnosis; D003952:Diagnostic Imaging; D016503:Drug Delivery Systems; D005260:Female; D064593:Heterografts; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D007783:Lactones / Q000737:chemistry*; D049449:Luminescence; D061986:MCF-7 Cells; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry; D055668:Photochemical Processes; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D007783:Lactones; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)
keywords: biodegradable polymers; fluorescence imaging; in vivo degradation; theranostic drug delivery; tissue engineering