title: Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing.
abstract: OBJECTIVE
  The objective of this study was to evaluate the effect of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) on bone healing.
  
  
  METHODS
  Twelve rabbits were included in this randomized, blinded, prospective study. 15-mm×10-mm-sized defects were created in the parietal bone, filled with PRP, PRF, CGF, and void. The bone mineral density and bone volume were analyzed with microscopic computed tomography (micro-CT) and histomorphometrics at the 6th and 12th week.
  
  
  RESULTS
  In micro-CT analysis, bone mineral density and bone volume were greater in the experimental group than in controls at both 6th and 12th week, but not among the experimental groups. Similarly, histomorphometric examination revealed that more bone formation was seen in the experimental group.
  
  
  CONCLUSIONS
  The addition of PRP, PRF, and CGF had significantly increased bone formation at the 6th week. The effect of PRP, PRF, and CGF was similar and may be useful in the future to increase the success rate of bone grafting.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Dental Research Institute, and Institute for Translational Dental Sciences, School of Dentistry, Pusan National University, Yangsan, South Korea.
authors.forename: Tae-Hoon
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Oral and Maxillofacial Surgery, Dental Research Institute, and Institute for Translational Dental Sciences, School of Dentistry, Pusan National University, Yangsan, South Korea.
authors.forename: Sung-Hee
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Regea, BioMediTech, Institute of Biomedical Technology, University of Tampere, Tampere, Finland; Department of Oral and Maxillofacial Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.
authors.forename: George K
authors.initials: GK
authors.lastname: Sándor
authors.affiliation: Department of Oral and Maxillofacial Surgery, Dental Research Institute, and Institute for Translational Dental Sciences, School of Dentistry, Pusan National University, Yangsan, South Korea. Electronic address: ydkimdds@pusan.ac.kr.
authors.forename: Yong-Deok
authors.initials: YD
authors.lastname: Kim
mesh_terms: D000818:Animals; D015519:Bone Density; D005337:Fibrin / Q000494:pharmacology*; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D010012:Osteogenesis / Q000187:drug effects*; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D011817:Rabbits; D012886:Skull; D014945:Wound Healing / Q000187:drug effects*; D055114:X-Ray Microtomography
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D005337:Fibrin
keywords: Bone density; Bone graft; Bone volume; Cytokines; Histomorphometrics