title: Risk factors for contact lens-induced papillary conjunctivitis associated with silicone hydrogel contact lens wear.
abstract: BACKGROUND
  Contact lens-induced papillary conjunctivitis (CLPC) continues to be a major cause of dropout during extended wear of contact lenses. This retrospective study explores risk factors for the development of CLPC during extended wear of silicone hydrogel lenses.
  
  
  METHODS
  Data from 205 subjects enrolled in the Longitudinal Analysis of Silicone Hydrogel Contact Lens study wearing lotrafilcon A silicone hydrogel lenses for up to 30 days of continuous wear were used to determine risk factors for CLPC in this secondary analysis of the main cohort. The main covariates of interest included substantial lens-associated bacterial bioburden and topographically determined lens base curve-to-cornea fitting relationships. Additional covariates of interest included history of adverse events, time of year, race, education level, gender, and other subject demographics. Statistical analyses included univariate logistic regression to assess the impact of potential risk factors on the binary CLPC outcome and Cox proportional hazards regression to describe the impact of those factors on time-to-CLPC diagnosis.
  
  
  RESULTS
  Across 12 months of follow-up, 52 subjects (25%) experienced CLPC. No associations were found between the CLPC development and the presence of bacterial bioburden, lens-to-cornea fitting relationships, history of adverse events, gender, or race. Contact lens-induced papillary conjunctivitis development followed the same seasonal trends as the local peaks in environmental allergens.
  
  
  CONCLUSIONS
  Lens fit and biodeposits, in the form of lens-associated bacterial bioburden, were not associated with the development of CLPC during extended wear with lotrafilcon A silicone hydrogel lenses.
authors.affiliation: Department of Ophthalmology and Visual Sciences (A.T., L.B.S.-F.), Case Western Reserve University, Cleveland, OH; Center for Health Care Research and Policy (T.E.L.), Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH; Department of Medicine (T.E.L.), Case Western Reserve University, Cleveland, OH; and Department of Epidemiology and Biostatistics (T.E.L., L.B.S.-F.), Case Western Reserve University, Cleveland, OH.
authors.forename: Angela
authors.initials: A
authors.lastname: Tagliaferri
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Love
authors.forename: Loretta B
authors.initials: LB
authors.lastname: Szczotka-Flynn
mesh_terms: D000293:Adolescent; D000328:Adult; D003233:Conjunctivitis, Allergic / Q000209:etiology*; D003262:Contact Lenses, Extended-Wear / Q000009:adverse effects*; D005260:Female; D006801:Humans; D020100:Hydrogels / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012826:Silicone Elastomers / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D020100:Hydrogels; D012826:Silicone Elastomers