title: Multifunctional Fe5 C2 nanoparticles: a targeted theranostic platform for magnetic resonance imaging and photoacoustic tomography-guided photothermal therapy.
abstract: Fe5 C2 NPs exhibit a high contrast in magnetic resonance imaging (MRI), superior photoacoustic tomography improvements, and efficient photothermal therapy (PTT) due to their unique core/shell structure, with a magnetic core and carbon shell. By conjugating a new class of affinity proteins (ZHER2:342), they can target to tumor cells with low cytotoxicity, and kill them through laser irritation. It is also possible to ablate tumors under guidance by MRI and PTT without noticeable side effects.
authors.affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, 100871, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.forename: Ce
authors.initials: C
authors.lastname: Yang
authors.forename: Jingdingsha
authors.initials: J
authors.lastname: Li
authors.forename: Yichen
authors.initials: Y
authors.lastname: Ding
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Muhammad Zubair
authors.initials: MZ
authors.lastname: Yousaf
authors.forename: Jian
authors.initials: J
authors.lastname: Lin
authors.forename: Rui
authors.initials: R
authors.lastname: Pang
authors.forename: Lanbin
authors.initials: L
authors.lastname: Wei
authors.forename: Lili
authors.initials: L
authors.lastname: Xu
authors.forename: Fugeng
authors.initials: F
authors.lastname: Sheng
authors.forename: Changhui
authors.initials: C
authors.lastname: Li
authors.forename: Gongjie
authors.initials: G
authors.lastname: Li
authors.forename: Lingyun
authors.initials: L
authors.lastname: Zhao
authors.forename: Yanglong
authors.initials: Y
authors.lastname: Hou
mesh_terms: D000818:Animals; D017554:Carbon Compounds, Inorganic / Q000627:therapeutic use; D045744:Cell Line, Tumor; D058085:Iron Compounds / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology* / Q000628:therapy*; D010316:Particle Size; D061088:Photoacoustic Techniques / Q000379:methods*; D010789:Phototherapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D017554:Carbon Compounds, Inorganic; D058085:Iron Compounds; C541825:iron carbide
keywords: iron carbides; magnetic resonance imaging; multifunctional probes; photoacoustic tomography; photothermal therapy