title: Glucose-6-phosphate dehydrogenase deficiency: an unusual cause of acute jaundice after paracetamol overdose.
abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the commonest human enzyme defect causing haemolytic anaemia after exposure to specific triggers. Paracetamol-induced haemolysis in G6PD deficiency is a rare complication and mostly reported in children. We report the first case (to the best of our knowledge) of acute jaundice without overt clinical features of a haemolytic crisis, in an otherwise healthy adult female following paracetamol overdose, due to previously undiagnosed G6PD deficiency. It is important that clinicians consider this condition when a patient presents following a paracetamol overdose with significant and disproportionate jaundice, without transaminitis or coagulopathy.
authors.affiliation: Department of Gastroenterology, Luton and Dunstable University Hospital NHS Trust, Luton, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Phillpotts
authors.forename: Elliot
authors.initials: E
authors.lastname: Tash
authors.forename: Sambit
authors.initials: S
authors.lastname: Sen
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000208:Acute Disease; D000328:Adult; D058633:Antipyretics / Q000009:adverse effects*; D062787:Drug Overdose / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000139:chemically induced* / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007565:Jaundice / Q000139:chemically induced* / Q000150:complications / Q000378:metabolism / Q000503:physiopathology
chemical_list: D058633:Antipyretics; D000082:Acetaminophen
keywords: Glucose-6-phosphate deficiency; Glucose-6-phosphate dehydrogenase; anaemia; haemolysis; paracetamol