title: Autoimmune response in children with dengue. Case reports.
abstract: Dengue is an infectious disease caused by the dengue virus (DV), which can progress to dengue hemorrhagic fever and dengue shock syndrome. DV causes the production of auto-antibodies against human cells. A variety of factors have been associated with macrophage activation syndrome, including infections, drugs and autoimmune pathologies (systemic lupus erythematosus, systemic onset juvenile idiopathic arthritis). We present three cases of patients that clinically developed an autoimmune response related to a DV infection. Our country currently has endemic cases of dengue, with hyperimmune responses. Therefore, the physician should consider this possibility in the presence of unusual conditions.
authors.affiliation: Servicio de Pediatría, Reumatología Pediátrica, Hospital Central del Instituto de Previsión Social, Asunción, Paraguay. Electronic address: zoiloma@hotmail.com.
authors.forename: Zoilo
authors.initials: Z
authors.lastname: Morel
authors.affiliation: Servicio de Pediatría, Hospital Central del Instituto de Previsión Social, Asunción, Paraguay.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ramírez
mesh_terms: D015551:Autoimmunity; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male
keywords: Autoinmune response; Dengue; Hemophagocytic syndrome; Macrophage activation syndrome; Respuesta autoinmune; Síndrome de activación de macrófagos; Síndrome hemofagocítico