title: Monoterpene citral derivatives as potential antimalarials.
abstract: Conjugated acid derivatives containing nitrogen have been synthesized from the simple acyclic monoterpene citral, using various reactions, including Wittig, Baylis Hillman, amide and ester condensations. Similarly, amine peroxides were synthesized by subjecting citral to Mannich type reaction with amines and t-butyl hydroperoxide. Molecules 3-10 were evaluated for antimalarial activity against erythrocytic stages of chloroquine sensitive P. falciparum strain 3D7. Four derivatives displayed interesting activity with an IC50< 2.5 microM, and warrant further investigations.
authors.forename: Soni
authors.initials: S
authors.lastname: Singh
authors.forename: Reena P
authors.initials: RP
authors.lastname: Khandare
authors.forename: Manish
authors.initials: M
authors.lastname: Sharma
authors.forename: Virendra K
authors.initials: VK
authors.lastname: Bhasin
authors.forename: Sujata V
authors.initials: SV
authors.lastname: Bhat
mesh_terms: D000080462:Acyclic Monoterpenes; D000962:Antimalarials / Q000032:analysis* / Q000138:chemical synthesis; D006801:Humans; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000080462:Acyclic Monoterpenes; D000962:Antimalarials; D039821:Monoterpenes; C007076:citral