title: Association between morphometric variables and nocturnal desaturation in sickle-cell anemia.
abstract: OBJECTIVE
  to evaluate associations between morphometric variables, cervical circumference (CC), and abdominal circumference (AC) with the presence of nocturnal desaturation in children and adolescents with sickle-cell anemia.
  
  
  METHODS
  all patients were submitted to baseline polysomnography, oral cavity measurements (maxillary intermolar distance, mandibular intermolar distance, and overjet), and CC and AC measurements.
  
  
  RESULTS
  a total of 85 patients were evaluated. A positive correlation was observed between the height/age Z-score and CC measurement (r = 0.233, p = 0.031). The presence of nocturnal desaturation was associated with CC (59.2± 9.3 vs. 67.5 ± 10.7, p = 0.006) and AC measurements (27.0 ± 2.0 vs. 29.0± 2.1, p = 0.028). There was a negative correlation between desaturation and maxillary intermolar distance (r = -0.365, p = 0.001) and mandibular intermolar distance (r = -0.233, p = 0.037).
  
  
  CONCLUSIONS
  the morphometric variables of CC and AC may contribute to raise suspicion of nocturnal desaturation in children and adolescents with sickle-cell anemia.
authors.affiliation: Faculdade de Medicina, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil. Electronic address: dra.cristinasalles@gmail.com.
authors.forename: Cristina
authors.initials: C
authors.lastname: Salles
authors.affiliation: Faculdade de Medicina, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Bispo
authors.affiliation: Faculdade de Medicina, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil.
authors.forename: Regina Terse
authors.initials: RT
authors.lastname: Trindade-Ramos
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000033:anatomy & histology; D008437:Maxilla / Q000033:anatomy & histology; D009055:Mouth / Q000033:anatomy & histology; D009333:Neck / Q000033:anatomy & histology*; D010100:Oxygen / Q000378:metabolism*; D017286:Polysomnography; D064346:Sagittal Abdominal Diameter / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology
chemical_list: D010100:Oxygen
keywords: Anemia falciforme; Apneia do sono; Desaturation; Dessaturação; Mandible; Mandíbula; Maxila; Maxilla; Sickle-cell anemia; Sleep apnea