title: Feasibility of slice width reduction for spiral cranial computed tomography using iterative image reconstruction.
abstract: OBJECTIVE
  To prospectively compare image quality of cranial computed tomography (CCT) examinations with varying slice widths using traditional filtered back projection (FBP) versus sinogram-affirmed iterative image reconstruction (SAFIRE).
  
  
  METHODS
  29 consecutive patients (14 men, mean age: 72 ± 17 years) referred for a total of 40 CCT studies were prospectively included. Each CCT raw data set was reconstructed with FBP and SAFIRE at 5 slice widths (1-5mm; 1mm increments). Objective image quality was assessed in three predefined regions of the brain (white matter, thalamus, cerebellum) using identical regions of interest (ROIs). Subjective image quality was assessed by 2 experienced radiologists. Objective and subjective image quality parameters were statistically compared between FBP and SAFIRE reconstructions.
  
  
  RESULTS
  SAFIRE reconstructions resulted in mean noise reductions of 43.8% in the white matter, 45.6% in the thalamus and 42.0% in the cerebellum (p<0.01) compared to FBP on non contrast-enhanced 1mm slice width images. Corresponding mean noise reductions on 1mm contrast-enhanced studies were 45.7%, 47.3%, and 45.0% in the white matter, thalamus, and cerebellum, respectively (p<0.01). There was no significant difference in mean attenuation of any region or slice width between the two reconstruction methods (all p>0.05). Subjective image quality of IR images was mostly rated higher than that of the FBP images.
  
  
  CONCLUSIONS
  Compared to FBP, SAFIRE provides significant reductions in image noise while increasing subjective image in CCT, particularly when thinner slices are used. Therefore, SAFIRE may allow utilization of thinner slices in CCT, potentially reducing partial volume effects and improving diagnostic accuracy.
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Haubenreisser
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Fink
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: John W
authors.initials: JW
authors.lastname: Nance
authors.affiliation: Siemens Healthcare, Division CT, Forchheim, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Sedlmair
authors.affiliation: Siemens Healthcare, Division CT, Forchheim, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schmidt
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Schoenberg
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany. Electronic address: thomas.henzler@medma.uni-heidelberg.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Henzler
mesh_terms: D000368:Aged; D000465:Algorithms; D002533:Cerebral Angiography / Q000379:methods*; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D059629:Signal-To-Noise Ratio; D036542:Tomography, Spiral Computed / Q000379:methods*
keywords: Brain; CT; Head; Iterative reconstruction; SAFIRE