title: The perivascular niche governs an autoregulatory network to support breast cancer metastasis.
abstract: Unravelling the autoregulatory network that induces and maintains cancer stem cell state may provide novel effective therapies against breast cancer metastasis. The perivascular niche develops elements that initiate the autoregulatory machine to induce and maintain cancer stem cells, but not EMT, among newly arrived tumour cells. Inhibition of one or more primary key elements that trigger this circuit may result in the prevention or cure of breast cancer metastasis.
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Fazilaty
authors.forename: Babak
authors.initials: B
authors.lastname: Behnam
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D015815:Cell Adhesion Molecules / Q000096:biosynthesis; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006706:Homeostasis; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology*; D000071250:Snail Family Transcription Factors; D019063:Tenascin / Q000096:biosynthesis; D019700:Thrombospondin 1 / Q000096:biosynthesis; D014157:Transcription Factors / Q000096:biosynthesis; D053782:Transforming Growth Factor beta3 / Q000096:biosynthesis; D059016:Tumor Microenvironment; D051176:beta Catenin / Q000096:biosynthesis
chemical_list: D015815:Cell Adhesion Molecules; C512835:POSTN protein, human; D000071250:Snail Family Transcription Factors; D019063:Tenascin; D019700:Thrombospondin 1; D014157:Transcription Factors; D053782:Transforming Growth Factor beta3; D051176:beta Catenin
keywords: autoregulatory network; breast cancer metastasis; cancer stem cell; epithelial to mesenchymal transition; transforming growth factor-beta