title: Joint effects of physical activity and BMI on risk of hypertension in women: a longitudinal study.
abstract: BACKGROUND
  There is debate as to whether physical activity counteracts the adverse effect of weight on health outcomes. We investigated how physical activity modifies the effect of body mass index (BMI) on hypertension risk.
  
  
  METHODS
  BMI, physical activity, and hypertension were measured at baseline and at three-year interval for 14 years (from 1996 to 2010), in 10,339 participants in the Australian Longitudinal Study on Women's Health. Generalised estimating equation models for binary repeated measures were performed to determine the individual and joint effects of BMI and physical activity on incident hypertension.
  
  
  RESULTS
  At baseline (mean age 47.6 ± 1.5 SD), 57% were healthy weight, 28% overweight, and 14% obese. Increasing BMI and decreasing physical activity were associated with increased risk of hypertension. Physical activity attenuated the positive association between weight and risk of hypertension, especially for obese women. Compared to healthy weight high active women, risk of hypertension in obese high active women was 3.4 times greater (OR 3.43, 95% CI 2.68, 4.39) and in obese inactive women 4.9 times greater (OR 4.91, 95% CI 3.92, 6.13).
  
  
  CONCLUSIONS
  Both physical activity and maintenance of a healthy body weight are associated with lower risk of hypertension. Physical activity reduced but did not remove the effect of obesity on hypertension risk.
authors.affiliation: Centre for Longitudinal and Life Course Research, School of Population Health, University of Queensland, Herston Road, Brisbane, QLD 4006, Australia.
authors.forename: Caroline
authors.initials: C
authors.lastname: Jackson
authors.affiliation: Centre for Longitudinal and Life Course Research, School of Population Health, University of Queensland, Herston Road, Brisbane, QLD 4006, Australia.
authors.forename: Gerrie-Cor
authors.initials: GC
authors.lastname: Herber-Gast
authors.affiliation: School of Human Movement Studies, University of Queensland, Blair Drive, St. Lucia, Brisbane, QLD 4072, Australia.
authors.forename: Wendy
authors.initials: W
authors.lastname: Brown
mesh_terms: D001315:Australia; D015992:Body Mass Index; D015444:Exercise; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control; D008137:Longitudinal Studies; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D016017:Odds Ratio; D050177:Overweight; D012016:Reference Values; D012307:Risk Factors; D057185:Sedentary Behavior; D016387:Women's Health