title: PSY-1, a Taxus chinensis var. mairei extract, inhibits cancer cell metastasis by interfering with MMPs.
abstract: Cancer is the most common disease worldwide, with death often occurring as a result of metastasis. Thus, interfering with metastasis has been regarded as a promising strategy to improve the current cancer treatments. However, exploration and development of novel anti-metastatic agents remains a major challenge. Recent evidence indicated that a polysaccharide isolated from Taxus yunnanensis suppressed tumor cells proliferation. With the objective of seeking bioactive extracts, we had previously isolated, purified and characterized a complex, water-soluble polysaccharides, PSY-1, from the leaves of Taxus chinensis var. mairei, and identified its anti-neoplastic effects. In this study, we focused on the effects of PSY-1 on cancer metastasis and its mechanism(s). The results illustrated that PSY-1 effectively suppressed the migration and invasion ability of the melanoma cancer cell line B16-F10, caused down-regulation of MMP-2 and MMP-9, and that the NF-kappaB pathway was involved in the anti-metastatic effects imposed by PSY-1.
authors.forename: Zao-Qian
authors.initials: ZQ
authors.lastname: Zheng
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Fu
authors.forename: Bo-Heng
authors.initials: BH
authors.lastname: Li
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Zhang
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Yang
authors.forename: Chuan-Wei
authors.initials: CW
authors.lastname: Xin
authors.forename: Jia-Na
authors.initials: JN
authors.lastname: Shi
authors.forename: Yin
authors.initials: Y
authors.lastname: Ying
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000032:analysis / Q000502:physiology; D020780:Matrix Metalloproteinase 9 / Q000032:analysis / Q000502:physiology; D061965:Matrix Metalloproteinase Inhibitors / Q000494:pharmacology*; D051379:Mice; D009362:Neoplasm Metastasis / Q000517:prevention & control; D018515:Plant Leaves / Q000737:chemistry; D011134:Polysaccharides / Q000494:pharmacology*; D020946:Taxus / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D061965:Matrix Metalloproteinase Inhibitors; D011134:Polysaccharides; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9