title: Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6).
abstract: Sulfur mustard (SM) is a blister agent with cytotoxic mechanism of action. There is no suitable treatment based on administration of an antidote. In this study, Wistar rats were exposed to SM in doses of 0-40 mg/kg body weight and treated with the compound HI-6. The treatment provided no significant effect on ferric reducing antioxidant power of blood and plasma. However, HI-6 caused an increase in the level of thiobarbituric acid reactive substances. This stressogenic response was presumably the cause of the significant elevation of the blood level of both glutathione reductase and reduced glutathione. HI-6 appears to be suitable for enhancing prophylactically oxidative stress protection from small oxidative insult.
authors.affiliation: Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 50001 Hradec Kralove, Czech Republic.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Pohanka
authors.affiliation: Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 50001 Hradec Kralove, Czech Republic.
authors.forename: Jakub
authors.initials: J
authors.lastname: Sobotka
authors.affiliation: Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 50001 Hradec Kralove, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Svobodova
authors.affiliation: Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 50001 Hradec Kralove, Czech Republic.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Stetina
keywords: acetylcholinesterase; blister agent; cholinergic anti-inflammatory pathway; oxidative insult; reactive oxygen species