title: Identification of a characteristic copy number alteration profile by high-resolution single nucleotide polymorphism arrays associated with metastatic sporadic colorectal cancer.
abstract: BACKGROUND
  Metastatic dissemination is the most frequent cause of death in patients with sporadic colorectal cancer (sCRC). It is believed that the metastatic process is related at least in part to a specific background of genetic alterations accumulated in cells from primary tumors, and the ability to detect such alterations is critical for the identification of patients with sCRC who are at risk of developing metastases.
  
  
  METHODS
  The authors used high-resolution, 500-K single nucleotide polymorphism arrays to identify copy number alteration profiles present at diagnosis in primary tumors from patients with metastatic (n = 23) versus nonmetastatic (n = 26) sCRC.
  
  
  RESULTS
  The results revealed a characteristic pattern of copy number alterations in metastatic sCRC tumors that involved losses of 23 regions at chromosomes 1p, 17p, and 18q, together with gains of 35 regions at chromosomes 7 and 13q.
  
  
  CONCLUSIONS
  In line with expectations, the copy number profile investigated involved multiple genes that were associated previously with sCRC (ie, SMAD2) and/or the metastatic process (ie, podocalyxin-like [PODXL]), and it also was associated with a poorer outcome.
authors.affiliation: General Cytometry Service-Nucleus, Department of Medicine and Cancer Research Center, Institute of Molecular Biology and Cellular Oncology of the University of Salamanca and Salamanca Institute of Biomedical Research, University of Salamanca, Salamanca, Spain.
authors.forename: María
authors.initials: M
authors.lastname: González-González
authors.forename: Celia
authors.initials: C
authors.lastname: Fontanillo
authors.forename: María M
authors.initials: MM
authors.lastname: Abad
authors.forename: María L
authors.initials: ML
authors.lastname: Gutiérrez
authors.forename: Ines
authors.initials: I
authors.lastname: Mota
authors.forename: Oscar
authors.initials: O
authors.lastname: Bengoechea
authors.forename: Ángel
authors.initials: Á
authors.lastname: Santos-Briz
authors.forename: Oscar
authors.initials: O
authors.lastname: Blanco
authors.forename: Emilio
authors.initials: E
authors.lastname: Fonseca
authors.forename: Juana
authors.initials: J
authors.lastname: Ciudad
authors.forename: Manuel
authors.initials: M
authors.lastname: Fuentes
authors.forename: Javier
authors.initials: J
authors.lastname: De Las Rivas
authors.forename: José A
authors.initials: JA
authors.lastname: Alcazar
authors.forename: Jacinto
authors.initials: J
authors.lastname: García
authors.forename: Luís
authors.initials: L
authors.lastname: Muñoz-Bellvis
authors.forename: Alberto
authors.initials: A
authors.lastname: Orfao
authors.forename: José M
authors.initials: JM
authors.lastname: Sayagués
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002869:Chromosome Aberrations; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D056915:DNA Copy Number Variations; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide
chemical_list: D009363:Neoplasm Proteins
keywords: colorectal carcinoma; copy number change; liver metastases; single nucleotide polymorphism array