title: Nanostructured lipid (NLCs) carriers as a bioavailability enhancement tool for oral administration.
abstract: BACKGROUND
  Nanostructured lipid carrier (NLCs) is the second generation solid lipid nanoparticles (NPs) made up of physiological, biocompatible, biodegradable, non-sensitizing and non-irritating lipids.
  
  
  OBJECTIVE
  The main objective of this review is to explore the role of NLCs system for delivering drugs by oral route and thus increasing the oral bioavailability.
  
  
  METHODS
  The present review article highlights the definition and types of NLCs and their importance as colloidal carriers including the production techniques and their formulation. This review article also deals with the fate of lipids used in the NLCs formulation and the NLCs toxicity.
  
  
  CONCLUSIONS
  On the basis of the literature survey done, it was concluded that the NLCs enhances the oral bioavailability of the drug and may decrease the side effects and toxicity of the lipids used in other polymeric NPs as NLCs uses physiological and biodegradable lipids.
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , Jamia Hamdard , Hamdard Nagar , New Delhi , India and.
authors.forename: Bharti
authors.initials: B
authors.lastname: Gaba
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , Jamia Hamdard , Hamdard Nagar , New Delhi , India and.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Fazil
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , Jamia Hamdard , Hamdard Nagar , New Delhi , India and.
authors.forename: Asgar
authors.initials: A
authors.lastname: Ali
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , Jamia Hamdard , Hamdard Nagar , New Delhi , India and.
authors.forename: Sanjula
authors.initials: S
authors.lastname: Baboota
authors.affiliation: b Khalsa College of Pharmacy , Amritsar , Punjab , India .
authors.forename: Jasjeet K
authors.initials: JK
authors.lastname: Sahni
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , Jamia Hamdard , Hamdard Nagar , New Delhi , India and.
authors.forename: Javed
authors.initials: J
authors.lastname: Ali
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D007408:Intestinal Absorption; D008055:Lipids / Q000737:chemistry* / Q000493:pharmacokinetics; D049329:Nanostructures / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature
chemical_list: D004337:Drug Carriers; D008055:Lipids; D013501:Surface-Active Agents
keywords: Bioavailability; biocompatibility; hydrophilic drugs; loading capacity; nano structured lipid carriers