title: Simulation and verification of macroscopic isotropy of hollow alginate-based microfibers.
abstract: A simulation of tensile strength of various alginate-based hollow microfibers using FEA analysis has been conducted with the hypothesis of macroscopic isotropy and linear elastic-plastic behavior. Results of student t-tests indicated that there was no significant difference between the experimental and simulated tensile strengths (p = 0.37, α = 0.05), while there was a significant reduction in elasticity as a result of chitosan coating (p = 0.024, α = 0.05). The hypothesis of macroscopic isotropy was verified by highly correlated (R(2) ≥ 0.92) theoretical and experimental elongation at break measurements, findings that could be extended to the failure analysis of alginate microfibers used in regenerative medicine.
authors.affiliation: a Biomedical, Chemical and Materials Engineering, San Jose State University , San Jose , CA , USA.
authors.forename: Sabra
authors.initials: S
authors.lastname: Djomehri
authors.affiliation: a Biomedical, Chemical and Materials Engineering, San Jose State University , San Jose , CA , USA.
authors.forename: Hanaa
authors.initials: H
authors.lastname: Zeid
authors.affiliation: a Biomedical, Chemical and Materials Engineering, San Jose State University , San Jose , CA , USA.
authors.forename: Alireza
authors.initials: A
authors.lastname: Yavari
authors.affiliation: b Department of Bioengineering , Santa Clara University , Santa Clara , CA , USA.
authors.forename: Maryam
authors.initials: M
authors.lastname: Mobed-Miremadi
authors.affiliation: c Mechanical and Aerospace Engineering, San Jose State University , San Jose , CA , USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Youssefi
authors.affiliation: d Department of Chemistry and Biochemistry , San Francisco State University , San Francisco , CA , USA.
authors.forename: Sindy
authors.initials: S
authors.lastname: Liao-Chan
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004548:Elasticity; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D019016:Mineral Fibers / Q000032:analysis*; D044968:Regenerative Medicine / Q000295:instrumentation; D013718:Tensile Strength
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D019016:Mineral Fibers; D020723:Glucuronic Acid; D048271:Chitosan
keywords: FEA; alginate; chitosan; hollow-fiber; isotropy; microfiber; stent