title: Structural polymorphism analysis of Chinese Mongolian ethnic group revealed by a new STR panel: genetic relationship to other groups.
abstract: Mongolian is the eighth largest ethnic minority on Chinese population data according to the 2010 census. In the present study, we presented the first report about the allelic frequencies and forensic statistical parameters at the 21 new STRs and analyzed linkage disequilibrium of pairwise loci in the Mongolian ethnic minority, China. Hardy-Weinberg equilibrium tests demonstrated no significant deviations except for the D1S1627 locus. The cumulative power of discrimination and power of exclusion of all the loci are 0.9999999999999999992576 and 0.9999997528, respectively. The results of analysis of molecular variance showed that significant differences between the Mongolian and the other eight populations were found at 1-9 STR loci. In population genetics, the results of principal component analysis, structure analysis, and phylogenetic reconstruction analysis indicated shorter genetic distance between the Mongolian group and the Ningxia Han. All the results suggest that the 21 new STR loci will contribute to Chinese population genetics and forensic caseworks in the Mongolian group.
authors.affiliation: Department of Pediatrics, Shaanxi Provincial People's Hospital, Xi'an, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.forename: Jun-Tao
authors.initials: JT
authors.lastname: Han
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Shen
authors.forename: Hua
authors.initials: H
authors.lastname: Wu
authors.forename: Guo-Lian
authors.initials: GL
authors.lastname: Yuan
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Zhao
authors.forename: Jiang-Wei
authors.initials: JW
authors.lastname: Yan
authors.forename: Hao-Tian
authors.initials: HT
authors.lastname: Meng
authors.forename: Yu-Dang
authors.initials: YD
authors.lastname: Zhang
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Liu
authors.forename: Hong-Dan
authors.initials: HD
authors.lastname: Wang
authors.forename: Richard E
authors.initials: RE
authors.lastname: White
authors.forename: Xing
authors.initials: X
authors.lastname: Wei
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D016000:Cluster Analysis; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D010802:Phylogeny; D011110:Polymorphism, Genetic; D025341:Principal Component Analysis
keywords: Mongolian; STR; Structural Polymorphisms