title: Cardiac standstill and circulatory flow arrest in surgical treatment of intracranial aneurysms: a historical review.
abstract: Since the first surgery for an intracranial aneurysm in 1931, neurological surgeons have long strived to determine the optimal methods of surgical correction. Significant challenges of aneurysm clipping include intraoperative rupture and complex dome morphology. Hypothermia, cardiopulmonary bypass, pharmacologically induced hypotension, and cardiac standstill are a few of the methodologies historically and currently employed in the management of these issues. In the 1980s, significant advances in pharmacology and anesthesiology led to the use of agents such as adenosine for chemically induced hypotension and eventually complete circulatory arrest. Since the institution of the use of these agents, the traditional methods of circulatory arrest under conditions of hypothermia and cardiopulmonary bypass have fallen out of favor. However, there still exists a subset of technically difficult aneurysms for which cardiac standstill, both chemical and hypothermic, remains a viable therapeutic option. In this paper, the authors describe the history of cardiac standstill by both hypothermic and chemically induced means as well as provide examples in which these techniques are still necessary.
authors.affiliation: Department of Neurological Surgery, The Neurological Institute.
authors.forename: James M
authors.initials: JM
authors.lastname: Wright
authors.forename: Christina L
authors.initials: CL
authors.lastname: Huang
authors.forename: Rahul
authors.initials: R
authors.lastname: Sharma
authors.forename: Sunil
authors.initials: S
authors.lastname: Manjila
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Barbara
authors.initials: B
authors.lastname: Dabb
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Bambakidis
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D006324:Heart Arrest, Induced / Q000266:history* / Q000379:methods*; D049673:History, 20th Century; D006801:Humans; D007036:Hypothermia, Induced / Q000266:history* / Q000379:methods*; D002532:Intracranial Aneurysm / Q000266:history / Q000601:surgery*
chemical_list: D000241:Adenosine