title: Animal models to evaluate bacterial biofilm development.
abstract: Medical biofilms have attracted substantial attention especially in the past decade. Animal models are contributing significantly to understand the pathogenesis of medical biofilms. In addition, animal models are an essential tool in testing the hypothesis generated from clinical observations in patients and preclinical testing of agents showing in vitro antibiofilm effect. Here, we describe three animal models - two non-foreign body Pseudomonas aeruginosa biofilm models and a foreign body Staphylococcus aureus model.
authors.affiliation: Department of Clinical Microbiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Kim
authors.initials: K
authors.lastname: Thomsen
authors.forename: Hannah
authors.initials: H
authors.lastname: Trøstrup
authors.forename: Claus
authors.initials: C
authors.lastname: Moser
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology*; D018407:Bacterial Physiological Phenomena; D018441:Biofilms / Q000254:growth & development*; D002056:Burns / Q000382:microbiology; D004195:Disease Models, Animal; D051379:Mice; D010019:Osteomyelitis / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000382:microbiology