title: Influence of Comorbidities: Neuropathy, Vasculopathy, and Diabetes on Healing Response Quality.
abstract: CONCLUSIONS
  Prolonged and nonhealing connective tissue injuries are often seen associated with common diseases, such as metabolic disorders, obesity, hypertension, arteriosclerosis, neuropathy, and diabetes mellitus and these influences result in considerable burden on society via the health care system, the economy, and quality of life for patients.
  
  
  BACKGROUND
  Emerging findings have established important new links in our understanding of effective connective tissue healing. Thereby, the function of the nervous system, vascular supply, and metabolic state of the patient can be directly linked to the quality of the connective tissue healing process.
  
  
  RESULTS
  As some of these conditions are also more common in individuals as they age, and aging can also impact healing effectiveness, such complications will have an emerging significant impact as the demographics of many societies change with expanding percentages of the populations >60-65 years of age.
  
  
  CONCLUSIONS
  Comorbidities have to be early identified in patients with acute wounds or planned surgery. Necessary interactions between physicians with different subspecialties have to be initiated to optimize wound healing potentials.
authors.affiliation: Section of Orthopedics, Department of Molecular Medicine and Surgery, Karolinska University Hospital , Karolinska Institutet, Solna, Sweden .
authors.forename: Paul W
authors.initials: PW
authors.lastname: Ackermann
authors.affiliation: Department of Surgery, McCaig Institute for Bone and Joint Health, University of Calgary , Calgary, Canada .
authors.forename: David A
authors.initials: DA
authors.lastname: Hart