title: Synthesis of 2´-hydroxy-4´-isoprenyloxychalcone derivatives with potential antidepressant-like activity.
abstract: A series of 2´-hydroxy-4´-isoprenyloxychalcone derivatives was synthesized and evaluated for its antidepressant- like activity using the FST and TST. All compounds exhibited the potential antidepressant-like activity in the FST and the TST through intraperitoneal injection. Among them, compounds 4i, 4l and 4n exhibited more potent antidepressant- like activity at a dose of 10 mg/kg. And, compounds 4i, 4l and 4n were also adequately absorbed in mice after oral administration at a dose of 30 mg/kg. In the 5-HT induced head-twitch test and yohimbine induced mortality test, compound 4i could increase the head-twitch and rise mortality in mice. The results suggested that the antidepressant effects of compound 4i may be related to via the serotonergic and noradrenergic system.
authors.forename: Chao
authors.initials: C
authors.lastname: Xie
authors.forename: Zhou
authors.initials: Z
authors.lastname: Peng
authors.forename: Shui-Lian
authors.initials: SL
authors.lastname: Zhao
authors.forename: Cheng-Yan
authors.initials: CY
authors.lastname: Pan
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Guan
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University, Zhoushan City, Zhejiang Province, 316022, P.R. China. glp730@163.com.
authors.forename: Xian-Yu
authors.initials: XY
authors.lastname: Sun
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D047188:Chalcones / Q000138:chemical synthesis / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy* / Q000503:physiopathology; D005106:Exploratory Behavior / Q000187:drug effects; D019417:Hindlimb Suspension; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology; D013329:Structure-Activity Relationship; D013550:Swimming; D015016:Yohimbine / Q000009:adverse effects
chemical_list: D000928:Antidepressive Agents; D047188:Chalcones; D015016:Yohimbine; D006916:5-Hydroxytryptophan