title: The influence of virus infections on the course of COPD.
abstract: Chronic obstructive pulmonary disease (COPD) is extensively influenced by viral infections. The mechanisms of how viral agents affect the pathogenesis and prognosis of COPD are numerous. In general, patients with infectious exacerbations are characterized by longer hospitalization periods and greater impairment of several lung function parameters than those with non-infectious exacerbations. Prodromal, clinical, and outcome parameters fail to distinguish virally from non-virally induced illnesses in cases of exacerbations. The importance of infections with respiratory and non-respiratory viral agents for pathogenesis and course of COPD is detailed. Human adenovirus, non-respiratory viruses including human immunodeficiency virus, human metapneumovirus, influenza virus, human rhinovirus, and respiratory syncytial virus are especially stressed.
authors.forename: H
authors.initials: H
authors.lastname: Frickmann
authors.forename: S
authors.initials: S
authors.lastname: Jungblut
authors.forename: T O
authors.initials: TO
authors.lastname: Hirche
authors.forename: U
authors.initials: U
authors.lastname: Groß
authors.forename: M
authors.initials: M
authors.lastname: Kuhns
authors.forename: A E
authors.initials: AE
authors.lastname: Zautner
keywords: COPD; chronic obstructive pulmonary disease; human adenovirus; human metapneumovirus; human rhinovirus; infection; influenza virus; respiratory syncytial virus; virus