title: Innate lymphoid cells and asthma.
abstract: Asthma is a complex and heterogeneous disease with several phenotypes, including an allergic asthma phenotype characterized by TH2 cytokine production and associated with allergen sensitization and adaptive immunity. Asthma also includes nonallergic asthma phenotypes, such as asthma associated with exposure to air pollution, infection, or obesity, that require innate rather than adaptive immunity. These innate pathways that lead to asthma involve macrophages, neutrophils, natural killer T cells, and innate lymphoid cells, newly described cell types that produce a variety of cytokines, including IL-5 and IL-13. We review the recent data regarding innate lymphoid cells and their role in asthma.
authors.affiliation: Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
authors.forename: Sanhong
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Medical Science, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hye Young
authors.initials: HY
authors.lastname: Kim
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: Ya-Jen
authors.initials: YJ
authors.lastname: Chang
authors.affiliation: Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
authors.forename: Rosemarie H
authors.initials: RH
authors.lastname: DeKruyff
authors.affiliation: Genentech, South San Francisco, Calif. Electronic address: umetsud@gene.com.
authors.forename: Dale T
authors.initials: DT
authors.lastname: Umetsu
mesh_terms: D000818:Animals; D001249:Asthma / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism
keywords: Airway hyperreactivity; allergy; asthma; influenza; innate lymphoid cells; natural killer T cells