title: Biomaterial-based scaffolds--current status and future directions.
abstract: BACKGROUND
  Biomaterial-based scaffold formulations (three-dimensional Porous matrix, nano-fibre mesh, hydrogels and microspheres) are the major components that are used to deliver the bioactive molecules into the body organs through different routes for an effective treatment of various diseases.
  
  
  METHODS
  Various fabrication techniques such as freeze-drying, polymerisation, spray drying, gas foaming, supercritical fluid technology, etc., are successfully used for fabrication of scaffold formulations. Due to their unique characteristics, these formulations are widely used against various diseases such as tuberculosis, bone defects, cartilage repair, skin diseases, cardiovascular diseases, periodontal diseases, wound dressing, etc.
  
  
  CONCLUSIONS
  The study of biomaterial-based scaffold formulations is exhilarating with novel approaches to drug/cell/gene delivery being developed all the time. At present, there is a huge extent of research being performed worldwide on all aspects of tissue engineering/drug or gene delivery. In the future, the main focus will be on the development of more patient compliant, sustained and controlled delivery systems against various diseases by modification of polymers, manufacturing technologies as well as carrier systems.
authors.affiliation: ISF College of Pharmacy, Department of Pharmaceutics , Moga, Punjab , India +91 814 626 5364 ; tarun.garg9@gmail.com.
authors.forename: Tarun
authors.initials: T
authors.lastname: Garg
authors.forename: Amit K
authors.initials: AK
authors.lastname: Goyal
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008863:Microspheres; D011108:Polymers; D016062:Porosity; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011108:Polymers