title: Primary non-clear-cell adenocarcinoma of the vagina in a diethylstilbestrol exposed woman.
abstract: A 54-year-old woman with a history of in-utero diethylstilbestrol (DES) exposure, who had a prior hysterectomy for symptomatic leiomyomata and dysmenorrhea, presented for vaginal bleeding. Vaginal biopsies showed a non-clear-cell adenocarcinoma, and the patient was subsequently treated with radiation therapy. We present a case of primary vaginal non-clear-cell adenocarcinoma in a patient with in-utero DES exposure. Continued monitoring of older DES-exposed women for vaginal lesions is warranted because of reported cases of non-clear-cell adenocarcinoma and persistent risk of clear cell adenocarcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Madigan Army Medical Center, 9040 Jackson Avenue, Tacoma, WA 98431.
authors.forename: Samit A
authors.initials: SA
authors.lastname: Patel
authors.affiliation: Department of Obstetrics and Gynecology, Multicare Health System, 311 S L Street, Tacoma, WA 98405.
authors.forename: Jan
authors.initials: J
authors.lastname: Sunde
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000139:chemically induced* / Q000473:pathology / Q000532:radiotherapy; D001706:Biopsy; D004054:Diethylstilbestrol / Q000009:adverse effects* / Q000627:therapeutic use; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007044:Hysterectomy; D018230:Leiomyoma, Epithelioid / Q000188:drug therapy / Q000601:surgery; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000601:surgery; D014625:Vaginal Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000532:radiotherapy
chemical_list: D004968:Estrogens, Non-Steroidal; D004054:Diethylstilbestrol