title: [Molecular biology in myelodysplastic syndromes and acute myeloid leukemias "smoldering"].
abstract: Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders of the myeloid lineage characterized by peripheral cytopenias and frequent leukemic evolution. MDS differ for clinical presentation, disease behavior and progression and this is the reflection of remarkable variability at molecular level. To this moment disease diagnosis is still dependent on bone marrow morphology that, although high concordance rates among experts are reported, remains subjective. Karyotype analysis is mandatory but diagnosis may be difficult in presence of normal karyotype or non-informative cytogenetics. Standardized molecular markers are needed to better define diagnosis, prediction of disease progression and prognosis. Furthermore, a molecular biology analysis could provide an important therapeutic tool towards tailored therapy and new insights in the disease's biology.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
authors.forename: Chiara
authors.initials: C
authors.lastname: Sartor
authors.forename: Cristina
authors.initials: C
authors.lastname: Papayannidis
authors.forename: Ilaria
authors.initials: I
authors.lastname: Iacobucci
authors.forename: Stefania
authors.initials: S
authors.lastname: Paolini
authors.forename: Cristina
authors.initials: C
authors.lastname: Clissa
authors.forename: Emanuela
authors.initials: E
authors.lastname: Ottaviani
authors.forename: Carlo
authors.initials: C
authors.lastname: Finelli
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001853:Bone Marrow / Q000473:pathology; D020732:Cytogenetic Analysis; D018450:Disease Progression; D006801:Humans; D007621:Karyotyping / Q000379:methods; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000473:pathology; D008967:Molecular Biology / Q000379:methods*; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000473:pathology; D011379:Prognosis
chemical_list: D015415:Biomarkers