title: Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF.
abstract: The aim of the present study was to determine how Endostar inhibits tumor angiogenesis and increases radiation sensitivity when combined with radiotherapy.In vitrostudies were conducted to analyze the expression levels of transforming growth factor-β1 (TGF-β1), hypoxia-inducible factor 1 (HIF-1α) and basic fibroblast growth factor (bFGF) in lung adenocarcinoma A549 cells, using the antiangiogenesis drug Endostar combined with radiotherapy. In addition, lung adenocarcinoma A549 cell apoptosis was detected via Hoechst staining. The combination of Endostar with radiotherapy was investigated and the results indicated that this combination significantly inhibited tumor cell proliferation and TGF-β1, HIF-1α and bFGF expression. Changes in gene expression were found to promote apoptosis, thus, enhancing the inhibition of tumor angiogenesis and ultimately inhibiting tumor cell growth, invasion and metastasis.
authors.affiliation: Department of Oncology, Wuhan University, Renmin Hospital, Wuhan, Hubei 430060, P.R. China.
authors.forename: Yaogui
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Oncology, Wuhan University, Renmin Hospital, Wuhan, Hubei 430060, P.R. China.
authors.forename: Yongfa
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Gastroenterology, Wuhan University, Renmin Hospital, Wuhan, Hubei 430060, P.R. China.
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Shen
authors.affiliation: Department of Oncology, Wuhan University, Renmin Hospital, Wuhan, Hubei 430060, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ge
authors.affiliation: Department of Oncology, Wuhan University, Renmin Hospital, Wuhan, Hubei 430060, P.R. China.
authors.forename: Yishan
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Oncology, Wuhan University, Renmin Hospital, Wuhan, Hubei 430060, P.R. China.
authors.forename: Changhu
authors.initials: C
authors.lastname: Li
keywords: endostar; radiation sensitivity; radiotherapy; tumor angiogenesis