title: Perioperative blood transfusion is associated with worse clinical outcomes in resected lung cancer.
abstract: The deleterious effect of perioperative allogeneic blood transfusion in patients with resected lung cancer has been controversial. We conducted this meta-analysis to answer the question of whether perioperative allogeneic blood transfusion adversely affects recurrence and survival in patients with resected lung cancer. Included were 23 studies with 6,474 patients. The result showed allogeneic blood transfusion was significantly associated with earlier recurrence and worse survival in patients with surgically resected lung cancer. We suggest transfusion policy should be stricter in lung cancer patients undergoing resection, especially with early-stage disease. Prospective large-scale studies are still warranted.
authors.affiliation: Department of Medical Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Pediatric Intensive Care Unit, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Lili
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Anesthesiology, Sichuan Cancer Hospital & Institute, Chengdu, Sichuan, People's Republic of China.
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Medical Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, People's Republic of China.
authors.forename: Jingrui
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Medical Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, People's Republic of China.
authors.forename: Changchuan
authors.initials: C
authors.lastname: Pan
authors.affiliation: Department of Medical Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, People's Republic of China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Cai
authors.affiliation: Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Chengdu, Sichuan, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
authors.affiliation: Department of Medical Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, People's Republic of China. Electronic address: wt19811026@163.com.
authors.forename: Xude
authors.initials: X
authors.lastname: Yin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001804:Blood Transfusion, Autologous / Q000009:adverse effects* / Q000379:methods; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology; D019990:Perioperative Care / Q000379:methods; D011013:Pneumonectomy / Q000379:methods / Q000401:mortality*; D011379:Prognosis; D018570:Risk Assessment; D016019:Survival Analysis