title: N-Bridged 1-deoxynojirimycin dimers as selective insect trehalase inhibitors.
abstract: A small set of N-bridged 1-deoxynojirimycin dimers has been synthesized and evaluated as potential inhibitors of insect trehalase from midge larvae of Chironomus riparius, porcine trehalase as the mammalian counterpart and α-amylase from human saliva. All the tested compounds (2-4) proved to be active (micromolar range activity) against insect trehalase, showing selectivity toward the insect glycosidase. No activity was observed against α-amylase.
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Cipolla
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Sgambato
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
authors.forename: Matilde
authors.initials: M
authors.lastname: Forcella
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Fusi
authors.affiliation: Department of Earth and Environmental Sciences, University of Milano-Bicocca, Piazza della Scienza 1, 20126 Milano, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Parenti
authors.affiliation: Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, I-50019 Sesto Fiorentino, Florence, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Cardona
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy. Electronic address: davide.bini@unimib.it.
authors.forename: Davide
authors.initials: D
authors.lastname: Bini
mesh_terms: D017485:1-Deoxynojirimycin / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D002683:Chironomidae / Q000201:enzymology*; D019281:Dimerization; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D007814:Larva / Q000201:enzymology; D009584:Nitrogen / Q000737:chemistry*; D014198:Trehalase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D017485:1-Deoxynojirimycin; D014198:Trehalase; D009584:Nitrogen
keywords: Deoxynojirimycin; Enzyme inhibitors; Iminosugars; Trehalase; Trehalose