title: Management of acute cholecystitis in cancer patients: a comparative effectiveness approach.
abstract: BACKGROUND
  Host factors and therapy characteristics predispose cancer patients to a high risk of acute cholecystitis. Management of cholecystitis is often difficult given complex decision making involving the underlying cancer, possible interruption of treatment, and surgical fitness of the patient.
  
  
  METHODS
  A management pathway was developed for cholecystitis in cancer patients which incorporated patient-specific survival and risks of recurrence. Estimates were obtained from a multistage systematic review. A decision tree with a lifetime horizon was constructed to compare conventional strategies [conservative treatment (CT), percutaneous cholecystostomy (PC) and definitive cholecystectomy (DC)] with the new pathway (NP). The decision tree was optimized for highest estimated survival. Sensitivity analyses were performed.
  
  
  RESULTS
  In low surgical risk patients with cancer-specific survival of 12 months, the NP yielded estimated survivals of 11.9 versus 11.8 (CT) versus 11.8 (PC) versus 11.9 months for the DC arm. For high-risk patients, the estimated survival was 11.6 (NP), 9.9 (DC), 11.4 (PC), and 11 (CT) months, respectively. The decision to perform a DC at 6 weeks after a PC was optimum in patients expected to survive 24 months (23.2 months from the NP) or with a shorter expected survival but a high recurrence risk (>20 %). Model estimates were robust in sensitivity analyses.
  
  
  CONCLUSIONS
  Incorporation of the surgical risk and the risk of recurrent cholecystitis, while balancing the patient-specific survival and the impact of antineoplastic therapy in the management of cholecystitis yields improved survival. This work provides measures to evaluate surgical judgment, and can augment the physician-patient decision making.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI, 53226, USA, tjayakri@mcw.edu.
authors.forename: Thejus T
authors.initials: TT
authors.lastname: Jayakrishnan
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Groeschl
authors.forename: Ben
authors.initials: B
authors.lastname: George
authors.forename: James P
authors.initials: JP
authors.lastname: Thomas
authors.forename: Sam
authors.initials: S
authors.lastname: Pappas
authors.forename: T Clark
authors.initials: TC
authors.lastname: Gamblin
authors.forename: Kiran K
authors.initials: KK
authors.lastname: Turaga
mesh_terms: D002763:Cholecystectomy / Q000379:methods*; D041881:Cholecystitis, Acute / Q000150:complications / Q000601:surgery*; D002767:Cholecystostomy / Q000379:methods*; D019468:Disease Management; D006801:Humans; D009369:Neoplasms / Q000150:complications*