title: New enzyme insights drive advances in commercial ethanol production.
abstract: Innovations at a small scale through enzyme discovery in the laboratory can have large scale impacts when rolled out in an industrial process, and this is evidenced in recent advances for commercial ethanol production. In the starch to ethanol processes, new enzyme product launches squeeze even more value from an already efficient process, as evidenced in new use of proteases for oil release and cellulases for downstream processing and ethanol yield. As for biomass to ethanol, diverse new thermophilic enzymes, expansins and auxiliary activity (AA) collections are growing rapidly. Our mechanistic understanding of the functions of AA family 9, cellulose binding modules, and cellulase/xylanase synergy will lead to continued improvements in overall enzymatic conversion, thus reducing cost for cellulosic ethanol (or other biofuel) production.
authors.affiliation: Novozymes Inc., 1445 Drew Ave, Davis, CA 95618, United States. Electronic address: PAHA@Novozymes.com.
authors.forename: Paul V
authors.initials: PV
authors.lastname: Harris
authors.affiliation: Novozymes Inc., 1445 Drew Ave, Davis, CA 95618, United States.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Novozymes North America, 77 Perrys Chapel Church Road, Franklinton, NC 27525, United States.
authors.forename: Nathaniel E
authors.initials: NE
authors.lastname: Kreel
authors.affiliation: Novozymes North America, 77 Perrys Chapel Church Road, Franklinton, NC 27525, United States.
authors.forename: Connie
authors.initials: C
authors.lastname: Kang
authors.affiliation: Novozymes Japan, Makuhari Techno Garden CB-6 3, Nakase 1-chome, Mihamaku-ku, Chiba-shi 261-8501, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Fukuyama
mesh_terms: D000681:Amylases / Q000378:metabolism; D000818:Animals; D056804:Biofuels; D018533:Biomass; D044602:Cellulases / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D056804:Biofuels; D000431:Ethanol; D000681:Amylases; D044602:Cellulases