title: Encapsulated cobalt-porphyrin as a catalyst for size-selective radical-type cyclopropanation reactions.
abstract: A cobalt-porphyrin catalyst encapsulated in a cubic M8 L6 cage allows cyclopropanation reactions in aqueous media. The caged-catalyst shows enhanced activities in acetone/water as compared to pure acetone. Interestingly, the M8 L6 encapsulated catalyst reveals size-selectivity. Smaller substrates more easily penetrate through the pores of the "molecular ship-in-a-bottle catalysts" and are hence converted faster than bigger substrates. In addition, N-tosylhydrazone sodium salts are easy to handle reagents for cyclopropanation reactions under these conditions.
authors.affiliation: Homogeneous and Supramolecular Catalysis Group, Van't Hoff Institute for Molecular Science (HIMS), University of Amsterdam (UvA), Science Park 904, 1098 XH Amsterdam (The Netherlands).
authors.forename: Matthias
authors.initials: M
authors.lastname: Otte
authors.forename: Petrus F
authors.initials: PF
authors.lastname: Kuijpers
authors.forename: Oliver
authors.initials: O
authors.lastname: Troeppner
authors.forename: Ivana
authors.initials: I
authors.lastname: Ivanović-Burmazović
authors.forename: Joost N H
authors.initials: JN
authors.lastname: Reek
authors.forename: Bas
authors.initials: B
authors.lastname: de Bruin
mesh_terms: D002384:Catalysis; D003035:Cobalt / Q000008:administration & dosage / Q000737:chemistry*; D003521:Cyclopropanes / Q000008:administration & dosage / Q000737:chemistry*; D058085:Iron Compounds / Q000737:chemistry; D008958:Models, Molecular; D016062:Porosity; D011166:Porphyrins / Q000737:chemistry*
chemical_list: D003521:Cyclopropanes; D058085:Iron Compounds; D011166:Porphyrins; D003035:Cobalt
keywords: cobalt; cyclopropanation; homogeneous catalysis; molecular flasks; porphyrins; radical chemistry