title: EEG-confirmed epileptic activity in a cat with VGKC-complex/LGI1 antibody-associated limbic encephalitis.
abstract: A 5-year-old, female client-owned cat presented with acute onset of focal epileptic seizures with orofacial twitching and behavioural changes. Magnetic resonance imaging showed bilateral temporal lobe hyperintensities and the EEG was consistent with ictal epileptic seizure activity. After antiepileptic and additional corticosteroid treatment, the cat recovered and by 10 months of follow-up was seizure-free without any problem. Retrospectively, antibodies to LGI1, a component of the voltage-gated potassium channel-complex, were identified. Feline focal seizures with orofacial involvement have been increasingly recognised in client-owned cats, and autoimmune limbic encephalitis was recently suggested as a possible aetiology. This is the first report of EEG, MRI and long-term follow-up of this condition in cats which is similar to human limbic encephalitis.
authors.affiliation: Clinic for Internal Medicine and Infectious Disease.
authors.forename: Akos
authors.initials: A
authors.lastname: Pakozdy
authors.affiliation: Clinic for Internal Medicine and Infectious Disease.
authors.forename: Ursula
authors.initials: U
authors.lastname: Glantschnigg
authors.affiliation: Clinic for Internal Medicine and Infectious Disease.
authors.forename: Michael
authors.initials: M
authors.lastname: Leschnik
authors.affiliation: Diagnostic Imaging, University of Veterinary Medicine, Vienna, Austria.
authors.forename: Harald
authors.initials: H
authors.lastname: Hechinger
authors.affiliation: Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
authors.forename: Teresa
authors.initials: T
authors.lastname: Moloney
authors.affiliation: Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
authors.forename: Bethan
authors.initials: B
authors.lastname: Lang
authors.affiliation: Institute of Experimental Medicine, Budapest, Hungary.
authors.forename: Peter
authors.initials: P
authors.lastname: Halasz
authors.affiliation: Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
authors.forename: Angela
authors.initials: A
authors.lastname: Vincent
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology*; D002415:Cats; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D020363:Limbic Encephalitis / Q000150:complications / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*; D012640:Seizures / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology
chemical_list: D024642:Potassium Channels, Voltage-Gated
keywords: EEG; epilepsy; feline; limbic encephalitis; seizure