title: Endothelial progenitor cells and pulmonary arterial hypertension.
abstract: Pulmonary arterial hypertension (PAH) is a progressive disease characterised by lung endothelial cell dysfunction and vascular remodelling. A number of studies now suggest that endothelial progenitor cells (EPCs) may induce neovascularisation and could be a promising approach for cell based therapy for PAH. On the contrary EPCs may contribute to pulmonary vascular remodelling, particularly in end-stage pulmonary disease. This review article will provide a brief summary of the relationship between PAH and EPCs, the application of the EPCs to PAH and highlight the potential clinical application of the EPCs cell therapy to PAH.
authors.affiliation: Central Laboratory, and Key Laboratory of Oral Maxillofacial-Head and Neck Medical Biology, Liaocheng People's Hospital, and Affiliated Liaocheng People's Hospital of Shandong University, Liaocheng, Shandong, 252000, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Chen
authors.affiliation: School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2650, Australia.
authors.forename: Padraig
authors.initials: P
authors.lastname: Strappe
authors.affiliation: Central Laboratory, and Key Laboratory of Oral Maxillofacial-Head and Neck Medical Biology, Liaocheng People's Hospital, and Affiliated Liaocheng People's Hospital of Shandong University, Liaocheng, Shandong, 252000, China.
authors.forename: Shuangfeng
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Liaocheng People's Hospital and Affiliated Liaocheng People's Hospital of Shandong University, Liaocheng, Shandong, 252000, China; School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2650, Australia. Electronic address: lwang@csu.edu.au.
authors.forename: Le-Xin
authors.initials: LX
authors.lastname: Wang
mesh_terms: D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology; D066253:Vascular Remodeling
keywords: Cell therapy; Endothelial progenitor cells (EPCs); Pulmonary arterial hypertension (PAH); Pulmonary disease; Vascular remodelling