title: The effects of phase III cardiac rehabilitation in serum and salivary Hs-CRP and anthropometric measurements in patients with coronary artery disease.
abstract: OBJECTIVE
  Cardiac rehabilitation is a key part in the treatment of coronary artery disease (CAD) by its anti-infammatory effects. However, the effect of exercise training programs on salivary concentrations of high-sensitivity C-reactive protein (hs-CRP) in patients with coronary artery disease has not been well studied. The objective of this study was to evaluate the effect of phase III cardiac rehabilitation on serum and salivary levels of hs-CRP, in relation to the anthropometric measurements of obesity and the relationship between salivary and serum levels of hs-CRP in CAD male patients.
  
  
  METHODS
  Forty male volunteers (45-75 years) with CAD participated in 6 to 8 weeks of moderate intensity aerobic exercise training consisting of 45 minutes sessions of treadmill, stationary bicycle and arm ergometer. Anthropometric measurements of obesity, serum level of hs-CRP, stimulated and nonstimulated salivary level of hs-CRP were measured at the beginning, in the middle and at the end of exercise sessions.
  
  
  RESULTS
  All anthropometric measurements increased (p < 0.05) following cardiac rehabilitation except waist-hip ratio. Serum hs-CRP level reduced by 36% independent to the anthropometric measurements changes. Stimulated and nonstimulated salivary hs-CRP level decreased 68 and 54%, respectively, after 24 sessions of cardiac rehabilitation. Nonstimulated salivary hs-CRP levels correlated to serum levels of hs-CRP at baseline and after 24 sessions (p < 0.05).
  
  
  CONCLUSIONS
  Phase III cardiac rehabilitation seems to be effective to improve serum and salivary hs-CRP concentrations independent of anthropometric measurements.
  
  
  CONCLUSIONS
  Nonstimulated salivary hs-CRP measurement could be a surrogate for blood measurement of hs-CRP during cardiac rehabilitation in male patients with CAD.
authors.affiliation: Physical Therapist, Department of Physical Therapy, Tehran University of Medical Sciences, Iran.
authors.forename: Boshra
authors.initials: B
authors.lastname: Jamshidpour
authors.affiliation: Assistant Professor, Department of Physical Therapy, Tehran University of Medical Sciences, Iran, e-mail: attarbashi@tums.ac.ir.
authors.forename: Behrouz Attarbashi
authors.initials: BA
authors.lastname: Moghadam
authors.affiliation: Assistant Professor, Department of Basic Sciences-Rehabilitation Research Center, Iran University of Medical Sciences, Iran.
authors.forename: Behnoosh
authors.initials: B
authors.lastname: Vasaghi-Gharamaleki
authors.affiliation: Associate Professor, Department of Physiology, AJA University of Medical Sciences, Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Mirzaii-Dizgah
authors.affiliation: Director of Cardiac Rehabilitation Department, Tehran Heart Center Tehran University of Medical Sciences, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Nejatian
mesh_terms: D000368:Aged; D000886:Anthropometry / Q000379:methods; D001642:Bicycling / Q000502:physiology; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002097:C-Reactive Protein / Q000032:analysis*; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy / Q000534:rehabilitation*; D016552:Ergometry / Q000379:methods; D005081:Exercise Therapy / Q000145:classification; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D055686:Metabolic Equivalent / Q000502:physiology; D008875:Middle Aged; D009765:Obesity / Q000145:classification*; D012463:Saliva / Q000737:chemistry*; D055105:Waist Circumference; D065927:Waist-Height Ratio; D049629:Waist-Hip Ratio; D016138:Walking / Q000502:physiology
chemical_list: D002097:C-Reactive Protein