title: Ruthenium(II)-catalyzed synthesis of isochromenes by C-H activation with weakly coordinating aliphatic hydroxyl groups.
abstract: Cationic ruthenium(II) complexes have been employed for the highly effective oxidative annulation of alkynes with benzyl alcohols to deliver diversely decorated isochromenes. The hydroxyl-directed C-H/O-H functionalization process proceeded efficiently under an atmosphere of air. Detailed mechanistic studies were indicative of a kinetically relevant C-H metalation.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August Universität, Tammanstrasse 2, 37077 Göttingen (Germany), Fax: (+49) 551-39-6777.
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Nakanowatari
authors.forename: Lutz
authors.initials: L
authors.lastname: Ackermann
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D019905:Benzyl Alcohol / Q000737:chemistry*; D002384:Catalysis; D002412:Cations / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry*; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001578:Benzopyrans; D002412:Cations; D056831:Coordination Complexes; D012428:Ruthenium; D019905:Benzyl Alcohol
keywords: CH activation; annulations; homogeneous catalysis; reaction mechanisms; ruthenium