title: Unlocking the treasure trove: from genes to schizophrenia biology.
abstract: Significant progress is being made in defining the genetic etiology of schizophrenia. As the list of implicated genes grows, parallel developments in gene editing technology provide new methods to investigate gene function in model systems. The confluence of these two research fields--gene discovery and functional biology--may offer novel insights into schizophrenia etiology. We review recent advances in these fields, consider the likely obstacles to progress, and consider strategies as to how these can be overcome.
authors.affiliation: *To whom correspondence should be addressed; Department of Psychiatry & Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland; tel: +353-1-8962467, fax: +353-1-8963405, e-mail: acorvin@tcd.ie.
authors.forename: Shane E
authors.initials: SE
authors.lastname: McCarthy
authors.forename: W Richard
authors.initials: WR
authors.lastname: McCombie
authors.forename: Aiden
authors.initials: A
authors.lastname: Corvin
mesh_terms: D064112:Clustered Regularly Interspaced Short Palindromic Repeats; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics*; D017422:Sequence Analysis, DNA
keywords: CRISPR; genomics; model; schizophrenia; sequencing; systems