title: Association of the IL-10 receptor A536G (S138G) loss-of-function variant with recurrent miscarriage.
abstract: OBJECTIVE
  We investigated the association of interleukin-10 receptor (IL10R1) loss-of-function variant A536G/S138G with recurrent pregnancy loss (RPL).
  
  
  METHODS
  Study subjects comprised 300 women with ≥3 miscarriages, and 350 control women.
  
  
  RESULTS
  Significantly higher 536G-allele frequency was seen in RPL cases, thus assigning pathogenic role for this allele. Significant difference in A536G/S138G genotypes distribution was seen between RPL cases and controls, evidenced by enrichment of 536A/G and 536G/G genotypes in RPL cases. Setting A/A genotype as reference (OR = 1.00), increased RPL risk was seen with 536A/G, and more in 536G/G carriers, thereby establishing dose-dependency.
  
  
  CONCLUSIONS
  IL10R1 loss-of-function A536/S138G polymorphism may contribute to RPL pathogenesis.
authors.affiliation: Laboratory of Human Genome and Multifactorial Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.
authors.forename: Kalthoum
authors.initials: K
authors.lastname: Magdoud
authors.forename: Radhia
authors.initials: R
authors.lastname: Hellal
authors.forename: Ramzi
authors.initials: R
authors.lastname: Zemni
authors.forename: Renaud
authors.initials: R
authors.lastname: Touraine
authors.forename: Touhami
authors.initials: T
authors.lastname: Mahjoub
authors.forename: Wassim Y
authors.initials: WY
authors.lastname: Almawi
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D060885:Multiplex Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D053701:Receptors, Interleukin-10 / Q000235:genetics*; D012189:Retrospective Studies
chemical_list: D053701:Receptors, Interleukin-10
keywords: IL-10 receptor; polymorphisms; pregnancy; recurrent miscarriage