title: [Doramectin intoxication in 3 kittens].
abstract: This case report describes 3 kittens with suspected doramectin toxicity. In a litter of 7 kittens treated with doramectin, 3 developed neurological symptoms. One kitten showed mild apathy and tremors, while a second one additionally presented behavioral changes and seizures that had to be treated with diazepam. Both kittens recovered completely. A third kitten was presented to us in coma 3 days following treatment with doramectin. Subsequently, this kitten developed behavioral changes such as aggression, hyperesthesia, tremors, and seizures and died 36 hours after presentation. Histopathologic examination of the brain showed cytotoxic edema and polioencephalomalacia. The doramectin dosage of the deceased kitten was 380 μg/kg.
authors.affiliation: Departement für klinische Veterinärmedizin der Universität Bern.
authors.forename: A
authors.initials: A
authors.lastname: Nentwig
authors.affiliation: Departement für klinische Forschung und Veterinary Public Health der Universität Bern.
authors.forename: A
authors.initials: A
authors.lastname: Oevermann
authors.affiliation: Klinik für Kleintiere, Veterinärmedizinische Fakultät der Universität Leipzig.
authors.forename: I A
authors.initials: IA
authors.lastname: Burgener
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D000871:Anthelmintics / Q000506:poisoning; D000977:Antiparasitic Agents / Q000506:poisoning*; D001522:Behavior, Animal / Q000187:drug effects; D002371:Cat Diseases / Q000139:chemically induced*; D002415:Cats; D017809:Fatal Outcome; D006941:Hyperesthesia / Q000139:chemically induced / Q000662:veterinary; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000506:poisoning; D012640:Seizures / Q000139:chemically induced / Q000662:veterinary
chemical_list: D000871:Anthelmintics; D000977:Antiparasitic Agents; D007559:Ivermectin; C084101:doramectin
keywords: Doramectin; Ivermectin; Polioencephalomalazie; Toxizität; doramectin; epileptiforme Anfälle; ivermectin; polioencephalomalacia; seizures; toxicity