title: Tug of war between survival and death: exploring ATM function in cancer.
abstract: Ataxia-telangiectasia mutated (ATM) kinase is a one of the main guardian of genome stability and plays a central role in the DNA damage response (DDR). The deregulation of these pathways is strongly linked to cancer initiation and progression as well as to the development of therapeutic approaches. These observations, along with reports that identify ATM loss of function as an event that may promote tumor initiation and progression, point to ATM as a bona fide tumor suppressor. The identification of ATM as a positive modulator of several signalling networks that sustain tumorigenesis, including oxidative stress, hypoxia, receptor tyrosine kinase and AKT serine-threonine kinase activation, raise the question of whether ATM function in cancer may be more complex. This review aims to give a complete overview on the work of several labs that links ATM to the control of the balance between cell survival, proliferation and death in cancer.
authors.affiliation: Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, 00179 Rome, Italy. venturina.stagni@gmail.com.
authors.forename: Venturina
authors.initials: V
authors.lastname: Stagni
authors.affiliation: Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, 00179 Rome, Italy. veronica.oropallo@gmail.com.
authors.forename: Veronica
authors.initials: V
authors.lastname: Oropallo
authors.affiliation: Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, 00179 Rome, Italy. giulia.fianco@gmail.com.
authors.forename: Giulia
authors.initials: G
authors.lastname: Fianco
authors.affiliation: Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, 00179 Rome, Italy. martina.antonelli87@gmail.com.
authors.forename: Martina
authors.initials: M
authors.lastname: Antonelli
authors.affiliation: Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, 00179 Rome, Italy. irene.cina@libero.it.
authors.forename: Irene
authors.initials: I
authors.lastname: Cinà
authors.affiliation: Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, 00179 Rome, Italy. daniela.barila@uniroma2.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Barilà
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics*; D015687:Cell Hypoxia / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D002470:Cell Survival / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D042822:Genomic Instability; D006801:Humans; D051379:Mice; D009369:Neoplasms; D018384:Oxidative Stress / Q000235:genetics; D051057:Proto-Oncogene Proteins c-akt / Q000096:biosynthesis; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D025521:Tumor Suppressor Proteins; D020794:Receptor Protein-Tyrosine Kinases; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D051057:Proto-Oncogene Proteins c-akt