title: Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure.
abstract: BACKGROUND
  Long noncoding RNAs represent a novel class of molecules regulating gene expression. Long noncoding RNAs are present in body fluids, but their potential as biomarkers was never investigated in cardiovascular disease.
  
  
  OBJECTIVE
  To study the role of long noncoding RNAs as potential biomarkers in heart disease.
  
  
  RESULTS
  Global transcriptomic analyses were done in plasma RNA from patients with or without left ventricular remodeling after myocardial infarction. Regulated candidates were validated in 3 independent patient cohorts developing cardiac remodeling and heart failure (788 patients). The mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) was downregulated early after myocardial infarction but upregulated during later stages. LIPCAR levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths.
  
  
  CONCLUSIONS
  LIPCAR is a novel biomarker of cardiac remodeling and predicts future death in patients with heart failure.
authors.affiliation: From the Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx (R.K., I.V., J.F., A.H., T.T.) and REBIRTH Excellence Cluster (T.T.), Hannover Medical School, Hannover, Germany; Inserm, U744, University Lille Nord de France, Lille, France (C.B., F.M., G.L., P.d.G., F.P.); Institut Pasteur de Lille, Lille, France (C.B., F.M., G.L., P.d.G., F.P.); Centre Hospitalier Régional et Universitaire de Lille, Lille, France (C.B., G.L., P.d.G., F.P.); Faculté de Médecine de Lille, Lille, France (C.B., G.L.); and National Heart and Lung Institute, Imperial College London, London, United Kingdom (T.T.).
authors.forename: Regalla
authors.initials: R
authors.lastname: Kumarswamy
authors.forename: Christophe
authors.initials: C
authors.lastname: Bauters
authors.forename: Ingo
authors.initials: I
authors.lastname: Volkmann
authors.forename: Fleur
authors.initials: F
authors.lastname: Maury
authors.forename: Jasmin
authors.initials: J
authors.lastname: Fetisch
authors.forename: Angelika
authors.initials: A
authors.lastname: Holzmann
authors.forename: Gilles
authors.initials: G
authors.lastname: Lemesle
authors.forename: Pascal
authors.initials: P
authors.lastname: de Groote
authors.forename: Florence
authors.initials: F
authors.lastname: Pinet
authors.forename: Thomas
authors.initials: T
authors.lastname: Thum
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D062085:RNA, Long Noncoding / Q000097:blood*; D015996:Survival Rate / Q000639:trends; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: D015415:Biomarkers; D062085:RNA, Long Noncoding
keywords: RNA, long noncoding; cardiac biomarkers; cardiac remodeling; circulating lncRNA; heart failure; mitochondria; myocardial infarction