title: Teratogenic effects of Mimosa tenuiflora in a rat model and possible role of N-methyl- and N,N-dimethyltryptamine.
abstract: Mimosa tenuiflora is a shrub/tree found in northeastern Brazil sometimes eaten by livestock and believed to be responsible for malformations observed in many animals from that region. The teratogenic compounds in M. tenuiflora are not known. This study used pregnant rats fed M. tenuiflora and components therefrom for bioassay and fractionation of possible teratogenic compounds. Rat pups were examined for cranial-facial defects and skeletal malformations. Experimental diets included M. tenuiflora leaf and seed material, extracts of leaf and seed, alkaloid extracts of leaf and seed, and N-methyltryptamine and N,N-dimethyltryptamine. Pups from mothers who received M. tenuiflora plant material, methanol extracts, alkaloid extracts, and purified N-methyltryptamines had a higher incidence of soft tissue cleft palate and skeletal malformations. Results are summarized as to the frequency of observed cleft palate and other noted malformations for each diet versus control.
authors.affiliation: Poisonous Plant Research Laboratory, Agriculture Research Service, U.S. Department of Agriculture , 1150 E. 1400 N., Logan, Utah 84341, United States.
authors.forename: Dale
authors.initials: D
authors.lastname: Gardner
authors.forename: Franklin
authors.initials: F
authors.lastname: Riet-Correa
authors.forename: Danilo
authors.initials: D
authors.lastname: Lemos
authors.forename: Kevin
authors.initials: K
authors.lastname: Welch
authors.forename: James
authors.initials: J
authors.lastname: Pfister
authors.forename: Kip
authors.initials: K
authors.lastname: Panter
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage; D000818:Animals; D001938:Brazil; D002972:Cleft Palate / Q000139:chemically induced / Q000473:pathology; D005260:Female; D031298:Mimosa / Q000737:chemistry*; D009139:Musculoskeletal Abnormalities / Q000139:chemically induced / Q000473:pathology; D004130:N,N-Dimethyltryptamine / Q000633:toxicity*; D018515:Plant Leaves / Q000737:chemistry; D011247:Pregnancy; D051381:Rats; D012639:Seeds / Q000737:chemistry; D013723:Teratogens / Q000633:toxicity*; D014197:Trees / Q000737:chemistry; D014363:Tryptamines / Q000633:toxicity*
chemical_list: D000470:Alkaloids; D013723:Teratogens; D014363:Tryptamines; C035668:N-methyltryptamine; C015293:indopan; D004130:N,N-Dimethyltryptamine