title: Valproate-induced hyperammonemic encephalopathy in a renal transplanted patient.
abstract: Neurological complications after renal transplantation constitute an important cause of morbidity and mortality. Their differential diagnosis is difficult and essential for subsequent patient's management. Valproate-induced hyperammonemic encephalopathy is an uncommon but serious effect of valproate treatment. Here, we describe the case of a 15-year-old girl who was on a long-term therapy with valproate due to epilepsy and revealed impaired consciousness with hyperammonemia 12 days after renal transplantation. After withdraw of valproate, patients' symptoms resolved within 24 h. Clinicians should increase their awareness for potential complication of valproate, especially in transplanted patients.
authors.affiliation: Department of Nephrology and Transplantation, Laiko General Hospital , Athens , Greece .
authors.forename: Christina
authors.initials: C
authors.lastname: Melexopoulou
authors.forename: Smaragdi
authors.initials: S
authors.lastname: Marinaki
authors.forename: Maria
authors.initials: M
authors.lastname: Darema
authors.forename: Chrysanthi
authors.initials: C
authors.lastname: Skalioti
authors.forename: Athina
authors.initials: A
authors.lastname: Efthimiou
authors.forename: George
authors.initials: G
authors.lastname: Zavos
authors.forename: John N
authors.initials: JN
authors.lastname: Boletis
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D001927:Brain Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D022124:Hyperammonemia / Q000139:chemically induced*; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000139:chemically induced; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid
keywords: Hyperammonemia; neurological complications; renal transplantation; valproate; valproate-induced hyperammonemic encephalopathy