title: The physiopathological role of IL-33: new highlights in bone biology and a proposed role in periodontal disease.
abstract: Interleukin-33 (IL-33) is a recently described member of the IL-1 family. IL-33 acts as an alarmin, chemoattractant, and nuclear factor. ST2, a member of the Toll-like receptor/IL-1R superfamily, the receptor of IL-33, triggers a plethora of downstream effectors and leads the activation of NFK-B, leading the expression of several genes. IL-33 and ST2 are expressed in the majority of cell types, and the IL-33/ST2 axis has a role in immune response, bone homeostasis, and osteoclastogenesis. Several studies show opposite roles of IL-33 in osteoclastogenesis and the implication in bone biology. Few works studied the role of IL-33 in periodontal disease, but we hypothesize a possible role of IL-33 in periodontal disease and bone loss.
authors.affiliation: Institute of Biomedical Sciences, Laboratory of Immunoparasitology, Federal University of Uberlândia, Avenida Pará 1720, Building 2B, Room 2B22, CP 592, 38400-902 Uberlândia, MG, Brazil.
authors.forename: Felipe Andrés Cordero
authors.initials: FA
authors.lastname: da Luz
authors.affiliation: Institute of Biomedical Sciences, Laboratory of Immunoparasitology, Federal University of Uberlândia, Avenida Pará 1720, Building 2B, Room 2B22, CP 592, 38400-902 Uberlândia, MG, Brazil.
authors.forename: Ana Paula Lima
authors.initials: AP
authors.lastname: Oliveira
authors.affiliation: Dentistry, Institute of Biomedical Sciences, Federal University of Uberlândia, CP 592, 38400-902 Uberlândia, MG, Brazil.
authors.forename: Daniella
authors.initials: D
authors.lastname: Borges
authors.affiliation: Institute of Biomedical Sciences, Laboratory of Immunoparasitology, Federal University of Uberlândia, Avenida Pará 1720, Building 2B, Room 2B22, CP 592, 38400-902 Uberlândia, MG, Brazil.
authors.forename: Paula Cristina
authors.initials: PC
authors.lastname: Brígido
authors.affiliation: Institute of Biomedical Sciences, Laboratory of Immunoparasitology, Federal University of Uberlândia, Avenida Pará 1720, Building 2B, Room 2B22, CP 592, 38400-902 Uberlândia, MG, Brazil.
authors.forename: Marcelo José Barbosa
authors.initials: MJ
authors.lastname: Silva
mesh_terms: D001842:Bone and Bones / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007107:Immune System; D007249:Inflammation; D007375:Interleukin-1 / Q000378:metabolism; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins / Q000502:physiology*; D008407:Mast Cells / Q000166:cytology; D009336:Necrosis; D010010:Osteoclasts / Q000166:cytology; D010510:Periodontal Diseases / Q000378:metabolism* / Q000503:physiopathology*; D053245:RANK Ligand / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D007375:Interleukin-1; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins; D053245:RANK Ligand; D011956:Receptors, Cell Surface