title: The effect of geometry on tumor thermal profile and its use in tumor functional state estimation.
abstract: Thermal differences between transplanted tumors and tumors in humans prevent the implementation of thermographic methods developed in mice models to human models and vise-versa. Transplantable tumors tend to have an extruding shape, which may affect the thermal patterns. This hypothesis was studied in phantom experiments and simulations. A correlation between tumor dimensions and relative temperature was found and used to estimate tumor functional state from previously published in vivo experiments. A correlation was found between temperature differences and tumor growth rates (tumor aggressiveness) and the effect of tumor treatment was demonstrated, showing the potential for in vivo, non-invasive tumor monitoring.
authors.affiliation: Dept. of Biomedical Engineering, Tel Aviv University, Tel, Aviv, Israel. Michal_tepper@yahoo.com.
authors.forename: Michal
authors.initials: M
authors.lastname: Tepper
authors.forename: Asaf
authors.initials: A
authors.lastname: Shoval
authors.forename: Israel
authors.initials: I
authors.lastname: Gannot
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000473:pathology*; D019047:Phantoms, Imaging; D013696:Temperature
keywords: cancer; temperature mapping; tumor thermometry; xenografts