title: Serotonin transporter polymorphic region 5-HTTLPR modulates risk for Parkinson's disease.
abstract: The association between the serotonin transporter gene (SLC6A4) polymorphisms, that is, 5-HTTLPR and rs25531, and Parkinson's disease (PD) remains to be further defined. We investigated this relationship in a Chinese cohort that comprised 504 PD patients and 504 controls. A total of 8 haplotypes and 14 genotypes of SLC6A4 were found in this population including a new variant of 5-HTTLPR, that is, 20G. Our results presented that 5-HTTLPR was associated with an aggravated risk for PD (p = 0.005). The rs25531 alone is not associated with PD susceptibility. However, in a sub-classification based on the impact of 5-HTTLPR and rs25531 on 5-HTT expression, we observed a significant difference in 5-HTT expressing distribution in the cohort, accompanied by an apparently lower level of 5-HTT high expressing group, that is, the LALA genotype, in the PD patients. Taken together, our data provide novel insight in support that the SLC6A4 polymorphisms, particularly 5-HTTLPR, and the serotonergic system are associated with PD etiology.
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Yan-Bing
authors.initials: YB
authors.lastname: Hu
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Jun-Mei
authors.initials: JM
authors.lastname: Lai
authors.affiliation: Department of Preventive Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Hui
authors.initials: H
authors.lastname: You
authors.affiliation: Department of Preventive Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Pei-Long
authors.initials: PL
authors.lastname: Hu
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zou
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Preventive Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: jianhong.zhu@gmail.com.
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Zhu
mesh_terms: D000368:Aged; D044466:Asian People; D015331:Cohort Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
keywords: 5-HTTLPR; Parkinson's disease; Polymorphism; Serotonin transporter; rs25531