title: Early therapy-related myeloid sarcoma and deletion of 9q22.32 to q31.1.
abstract: Survival following childhood neuroblastoma is improving with low rates of secondary myeloid neoplasms. We describe a 13-month-old male with intermediate risk neuroblastoma who developed an isolated scalp therapy-related myeloid sarcoma (t-MS). Developmental delays and two distinct malignancies prompted constitutional evaluation. Chromosomal microarray identified a 7.3 Mb deletion of 9q22.32 to 9q31.1. He remains in remission 11 months following hematopoietic cell transplant. Unusual presentations of rare diseases necessitate a multidisciplinary approach and adaptation of standardized protocols to accommodate increased risks imposed by genetic variants.
authors.affiliation: Pediatric Hematology, Oncology, and Bone Marrow Transplant, Medical College of Wisconsin, Milwaukee, Wisconsin; Midwest Center for Cancer and Blood Disorders, Milwaukee, Wisconsin.
authors.forename: Molly M
authors.initials: MM
authors.lastname: Brickler
authors.forename: Donald G
authors.initials: DG
authors.lastname: Basel
authors.forename: Gabriela
authors.initials: G
authors.lastname: Gheorghe
authors.forename: David M
authors.initials: DM
authors.lastname: Margolis
authors.forename: Michael E
authors.initials: ME
authors.lastname: Kelly
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Ehrhardt
mesh_terms: D002872:Chromosome Deletion; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003131:Combined Modality Therapy / Q000009:adverse effects*; D002658:Developmental Disabilities / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D009447:Neuroblastoma / Q000150:complications / Q000628:therapy*; D011379:Prognosis; D023981:Sarcoma, Myeloid / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D055502:Secondary Prevention
keywords: granulocytic sarcoma; myeloid sarcoma; neuroblastoma; therapy-related