title: An efficient process for lactic acid production from wheat straw by a newly isolated Bacillus coagulans strain IPE22.
abstract: A thermophilic lactic acid (LA) producer was isolated and identified as Bacillus coagulans strain IPE22. The strain showed remarkable capability to ferment pentose, hexose and cellobiose, and was also resistant to inhibitors from lignocellulosic hydrolysates. Based on the strain's promising features, an efficient process was developed to produce LA from wheat straw. The process consisted of biomass pretreatment by dilute sulfuric acid and subsequent SSCF (simultaneous saccharification and co-fermentation), while the operations of solid-liquid separation and detoxification were avoided. Using this process, 46.12 g LA could be produced from 100g dry wheat straw with a supplement of 10 g/L corn steep liquid powder at the cellulase loading of 20 FPU (filter paper activity units)/g cellulose. The process by B. coagulans IPE22 provides an economical route to produce LA from lignocellulose.
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China; University of the Chinese Academy of Sciences, Beijing 100049, China; College of Life Sciences, Hebei University, Baoding 071002, China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Chemical and Biochemical Engineering, Center for Bioprocess Engineering, Technical University of Denmark, Building 229, DK-2800 Kgs. Lyngby, Denmark.
authors.forename: Jianquan
authors.initials: J
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Benkun
authors.initials: B
authors.lastname: Qi
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: yhwan@home.ipe.ac.cn.
authors.forename: Yinhua
authors.initials: Y
authors.lastname: Wan
mesh_terms: D001407:Bacillus / Q000302:isolation & purification / Q000378:metabolism*; D005285:Fermentation; D019344:Lactic Acid / Q000096:biosynthesis*; D014908:Triticum / Q000378:metabolism*
chemical_list: D019344:Lactic Acid
keywords: Bacillus coagulans; Hemicellulosic hydrolysates; Lactic acid; SSCF; Wheat straw