title: Effect of alcohols on filamentation, growth, viability and biofilm development in Candida albicans.
abstract: In this study we report the potential of alcohols as morphogenetic regulators in Candida albicans. All the alcohols tested influenced various modes of growth like planktonic as well as biofilm forms. Viability was affected at high concentrations. Among the alcohols, the response of C. albicans to amyl alcohol (pentanol) was noteworthy. Amyl alcohol at a concentration 0.5% which was not inhibitory to growth and viability specifically inhibited morphogenetic switching from yeast to hyphal forms. It also inhibited normal biofilm development favoring yeast dominated biofilms. Based on this study we hypothesize that alcohols produced under anaerobic conditions may not favor biofilm development and support dissemination of yeast cells. Since anaerobic conditions are not found to favor production of quorum sensing molecules like farnesol, the alcohols may play a role in morphogenetic regulation.
authors.affiliation: DST-FIST and UGC-SAP Sponsored School of Life Sciences, SRTM University, Nanded, M.S, India.
authors.forename: Nitin M
authors.initials: NM
authors.lastname: Chauhan
authors.affiliation: DST-FIST and UGC-SAP Sponsored School of Life Sciences, SRTM University, Nanded, M.S, India.
authors.forename: Ravikumar B
authors.initials: RB
authors.lastname: Shinde
authors.affiliation: DST-FIST and UGC-SAP Sponsored School of Life Sciences, SRTM University, Nanded, M.S, India.
authors.forename: S Mohan
authors.initials: SM
authors.lastname: Karuppayil
mesh_terms: D000438:Alcohols / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development*; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology*; D050296:Microbial Viability / Q000187:drug effects
chemical_list: D000438:Alcohols
keywords: Candida albicans; alcohols; biofilms; morphogenesis; signalling; yeast metabolism