title: Antioxidant, anti-inflammatory potential and chemical constituents of Origanum dubium Boiss., growing wild in Cyprus.
abstract: Origanum dubium Boiss. is a flavouring herb widely used in Cyprus. In this study, both lipophilic and polar extracts of the aerial parts of O. dubium were investigated for their chemical contents and their antioxidant potential. Overall, 20 constituents were isolated and identified, belonging mainly to three significant classes of compounds: terpenes, phenolic derivatives, such as hydroquinone glycosides and flavonoids and alicyclic derivatives. None of them was previously reported as constituent of O. dubium The inhibitory potencies of all total extracts and the isolated compounds on lipid peroxidation and their interaction with 1,1-diphenyl-picrylhydrazyl (DPPH) activity is discussed. The polar extract showed strong interaction with DPPH stable radical and significant inhibition of lipoxygenase and lipid peroxidation.
authors.affiliation: Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens , Athens , Greece .
authors.forename: Anastasia
authors.initials: A
authors.lastname: Karioti
authors.forename: Tanja
authors.initials: T
authors.lastname: Milošević-Ifantis
authors.forename: Nikitas
authors.initials: N
authors.lastname: Pachopos
authors.forename: Niki
authors.initials: N
authors.lastname: Niryiannaki
authors.forename: Dimitra
authors.initials: D
authors.lastname: Hadjipavlou-Litina
authors.forename: Helen
authors.initials: H
authors.lastname: Skaltsa
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors; D003535:Cyprus; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification; D019787:Linoleic Acid / Q000737:chemistry; D015227:Lipid Peroxidation; D008084:Lipoxygenase / Q000737:chemistry; D031341:Origanum / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification; D010851:Picrates / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000737:chemistry*; D010940:Plant Proteins / Q000037:antagonists & inhibitors; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005419:Flavonoids; D006027:Glycosides; D006873:Hydroquinones; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D010940:Plant Proteins; D013729:Terpenes; D019787:Linoleic Acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D008084:Lipoxygenase
keywords: 1,1-Diphenyl-picrylhydrazyl stable radical; flavonoids; hydroquinone glycosides; lipid peroxidation; lipoxygenase; terpenes