title: Serum cholesterol and triglyceride concentrations in diabetic patients with subclinical hypothyroidism.
abstract: OBJECTIVE
  To assess whether subclinical hypothyroidism is associated to elevations in serum cholesterol and triglyceride levels in patients with type 2 diabetes.
  
  
  METHODS
  From a total population of 1,112 patients with type 2 diabetes screened for thyroid dysfunction (thyrotropin measurement), a group of 325 patients with normal thyroid function and another group of 29 patients with subclinical hypothyroidism were selected. No patient had known dyslipidemia or was taking lipid lowering medication.
  
  
  RESULTS
  Patients with subclinical hypothyroidism had serum levels of total cholesterol (4.88 ± 0.74 mmol/L), HDL cholesterol (1.37 ± 0.34 mmol/L), LDL cholesterol (2.94 ± 0.58 mmol/L), and triglycerides (1.05 [0.88-1.41] mmol/L) that did not significantly differ from those found in euthyroid patients (4.79 ± 0.83, 1.33 ± 0.36, 2.87 ± 0.76, and 1.11 [0.81-1.43] mmol/L, respectively). Multiple regression analysis showed no association between TSH and serum lipid levels.
  
  
  CONCLUSIONS
  These results suggest that, in our population, there are no significant differences in serum cholesterol and triglyceride levels between diabetic patients with normal and reduced thyroid function.
authors.affiliation: Servicio de Endocrinología, Hospital Ramón y Cajal, Madrid, España; Universidad de Alcalá de Henares, Alcalá de Henares, Madrid, España. Electronic address: juanjose.diez@salud.madrid.org.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Díez
authors.affiliation: Servicio de Endocrinología, Hospital Ramón y Cajal, Madrid, España.
authors.forename: Pedro
authors.initials: P
authors.lastname: Iglesias
mesh_terms: D000368:Aged; D002784:Cholesterol / Q000097:blood*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D008297:Male; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides; D002784:Cholesterol
keywords: Cholesterol; Colesterol; Diabetes tipo 2; Hipotiroidismo subclínico; Subclinical hypothyroidism; Triglicéridos; Triglycerides; Type 2 diabetes