title: Combined liver-kidney transplantation: experience at a Brazilian university hospital.
abstract: BACKGROUND
  Combined liver-kidney transplant is a routine procedure in many transplant centers. The increase in its number coincided with the introduction in 2002 of the MELD (Model for End-stage Liver Disease) score for allocation of livers, prioritizing patients with renal dysfunction. Aim : To analyze the experience with combined liver-kidney transplantation in a liver transplant center in Brazil.
  
  
  METHODS
  A retrospective review was conducted. All transplants were performed using grafts from deceased donors.
  
  
  RESULTS
  Sixteen combined liver-kidney transplantations were performed in the same period, which corresponds to 2.7% and 2.5% of the kidney and liver transplants, respectively. Fourteen patients were male (87.5 %) and two were female (12.5%). The average patients and donors age was 57.3 ± 9.1 and 32.7 ± 13.1, respectively. The MELD score mean was 23.6 ± 3.67. The main cause of liver dysfunction were chronic hepatitis C virus (n=9). As for renal dysfunction, diabetic nephropathy (n=4) was the most frequent. There were six deaths, two of them by severe dysfunction of the liver graft and four by infectious causes. The 1, 3 and 5 years survival rate in patients undergoing liver-kidney transplantations was 68.8%, 57.3% and 57.3%, respectively.
  
  
  CONCLUSIONS
  The survival rates achieved in this series are considered satisfactory and show that this procedure has an acceptable morbidity and survival.
authors.affiliation: Department of Surgery, Federal University of Ceara, Fortaleza, CE, Brazil.
authors.forename: Francisca Jovita de Oliveira
authors.initials: FJ
authors.lastname: Veras
authors.affiliation: Department of Surgery, Federal University of Ceara, Fortaleza, CE, Brazil.
authors.forename: Gustavo Rêgo
authors.initials: GR
authors.lastname: Coelho
authors.affiliation: Department of Surgery, Federal University of Ceara, Fortaleza, CE, Brazil.
authors.forename: Bartolomeu Alves
authors.initials: BA
authors.lastname: Feitosa-Neto
authors.affiliation: Department of Surgery, Federal University of Ceara, Fortaleza, CE, Brazil.
authors.forename: João Batista Gadelha
authors.initials: JB
authors.lastname: Cerqueira
authors.affiliation: Department of Surgery, Federal University of Ceara, Fortaleza, CE, Brazil.
authors.forename: Regina Célia F Gomes
authors.initials: RC
authors.lastname: Garcia
authors.affiliation: Department of Surgery, Federal University of Ceara, Fortaleza, CE, Brazil.
authors.forename: José Huygens Parente
authors.initials: JH
authors.lastname: Garcia
mesh_terms: D000328:Adult; D001938:Brazil; D005260:Female; D006785:Hospitals, University; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods; D016031:Liver Transplantation / Q000379:methods; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies