title: New schiartane-type triterpene from Kadsura heteroclita and their cytotoxic activities.
abstract: One new schiartane-type triterpene, heteroclitalactone N (1), and four known compounds (2-5), seco-coccinic acid F, dihydroguaiaretic acid, schizanrin F, and kadsuralignan B were isolated from the stems of Kadsura heteroclita. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-, 2D-NMR, and CD spectra as well as by comparing with the NMR data reported in the literature. The cytotoxic activities of all isolated compounds were evaluated on three human cancer cell lines. Compound 3 exhibited moderate to weak cytotoxic activities on three human cancer cell lines, OVCAR, HT-29, and A-549, with IC50 values ranging from 16.2 to 36.4 microM.
authors.forename: Pham Thi Hong
authors.initials: PT
authors.lastname: Minh
authors.forename: Do Tien
authors.initials: do T
authors.lastname: Lam
authors.forename: Nguyen Quyet
authors.initials: NQ
authors.lastname: Tien
authors.forename: Nguyen Ngoc
authors.initials: NN
authors.lastname: Tuan
authors.forename: Vu Phuong
authors.initials: VP
authors.lastname: Nhung
authors.forename: Nong
authors.initials: N
authors.lastname: Van Hai
authors.forename: Phan
authors.initials: P
authors.lastname: Van Kiem
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Chau
authors.initials: C
authors.lastname: Van Minh
authors.forename: Park Seon
authors.initials: PS
authors.lastname: Ju
authors.forename: Kim Seung
authors.initials: KS
authors.lastname: Hyun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D032135:Kadsura / Q000737:chemistry*; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C588203:heteroclitalactone N