title: Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer.
abstract: Chronic ultraviolet (UV) radiation exposure is a major cause of skin cancer. A novel series of hybrid derivatives (I-VIII) for use in sunscreen formulations were synthesized by molecular hybridization of t-resveratrol, avobenzone, and octyl methoxycinnamate, and were characterized. The antioxidant activity values for VIII were comparable than to those of t-resveratrol. Compounds I-III and VI demonstrated Sun Protector Factor superior to that of t-resveratrol. Compounds I and IV-VIII were identified as new, broad-spectrum UVA filters while II-III were UVB filters. In conclusion, novel hybrid derivatives with antioxidant effects have emerged as novel photoprotective agents for the prevention of skin cancer.
authors.affiliation: Lapdesf-Laboratório de Pesquisa e Desenvolvimento de Fármacos, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista-UNESP, Rodovia Araraquara Jaú Km 01, 14801-902 Araraquara, SP, Brazil.
authors.forename: Juliana Santana
authors.initials: JS
authors.lastname: Reis
authors.affiliation: Lapdesf-Laboratório de Pesquisa e Desenvolvimento de Fármacos, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista-UNESP, Rodovia Araraquara Jaú Km 01, 14801-902 Araraquara, SP, Brazil.
authors.forename: Marcos Antonio
authors.initials: MA
authors.lastname: Corrêa
authors.affiliation: Lapdesf-Laboratório de Pesquisa e Desenvolvimento de Fármacos, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista-UNESP, Rodovia Araraquara Jaú Km 01, 14801-902 Araraquara, SP, Brazil.
authors.forename: Man Chin
authors.initials: MC
authors.lastname: Chung
authors.affiliation: Lapdesf-Laboratório de Pesquisa e Desenvolvimento de Fármacos, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista-UNESP, Rodovia Araraquara Jaú Km 01, 14801-902 Araraquara, SP, Brazil. Electronic address: santosjl@fcfar.unesp.br.
authors.forename: Jean Leandro
authors.initials: JL
authors.lastname: Dos Santos
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D002934:Cinnamates / Q000737:chemistry; D006801:Humans; D011427:Propiophenones / Q000737:chemistry; D000077185:Resveratrol; D012878:Skin Neoplasms / Q000517:prevention & control; D013267:Stilbenes / Q000737:chemistry; D059405:Sun Protection Factor; D013473:Sunscreening Agents / Q000138:chemical synthesis* / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D000975:Antioxidants; D002934:Cinnamates; D011427:Propiophenones; D013267:Stilbenes; D013473:Sunscreening Agents; C118580:octylmethoxycinnamate; C049935:avobenzone; D000077185:Resveratrol
keywords: Antioxidant; Avobenzone; Molecular hybridization; Octyl methoxycinnamate; Photoprotection; Sunscreens; UV filters; UV radiation; t-Resveratrol