title: [A clinical analysis of thyrotropin-secreting pituitary adenomas in 20 patients].
abstract: OBJECTIVE
  To explore the clinical characteristics of thyrotropin-secreting pituitary adenomas.
  
  
  METHODS
  A total of 20 patients with thyrotropin-secreting pituitary adenomas hospitalized in Shanghai Huashan Hospital from 2006 to 2013 were enrolled in the study. The clinical features, hormone levels, imaging findings, treatment and follow-up data were reviewed and analyzed.
  
  
  RESULTS
  Most of the patients were young and middle-aged with (40.0 ± 14.5) years old. The disease duration varied from 1 month to 15 years. Among them, 13 cases (65%) presented with thyrotoxicosis and/or thyroid goiters and 9 (45%) presented with symptoms of intracranial compression. All patients had unsuppressed levels of thyroid stimulating hormone (TSH) with elevated levels of thyroid hormones. Pituitary lesions were found in all patients by neuroimaging. Pituitary adenomectomy, and/or somatostatin analogs and/or radiotherapy were applied in all patients after definitive diagnosis. Restored euthyroidism and shrinks pituitary adenomas with no progression were observed in 18 patients. Relapse was found in 1 patient and another patient was lost to follow up.
  
  
  CONCLUSIONS
  Thyrotropin-secreting pituitary adenomas mainly present with thyrotoxicosis and/or pituitary tumor. Comprehensive therapy, including adenomectomy, somatostatin analogues and radiotherapy, is often needed for the management.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhao
authors.forename: Yehong
authors.initials: Y
authors.lastname: Yang
authors.forename: Hongying
authors.initials: H
authors.lastname: Ye
authors.forename: Zhaoyun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Lu
authors.forename: Xi
authors.initials: X
authors.lastname: Wu
authors.forename: Renming
authors.initials: R
authors.lastname: Hu
authors.forename: Linuo
authors.initials: L
authors.lastname: Zhou
authors.forename: Shiqi
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Huashan Hospital, Fudan University, Shanghai 200040, China. Email: yimingli@fudan.edu.cn.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D013972:Thyrotropin / Q000378:metabolism*; D055815:Young Adult
chemical_list: D013972:Thyrotropin