title: Comparative assessment of selected metals in the scalp hair and nails of lung cancer patients and controls.
abstract: Lung cancer is seriously threatening human health and exposure to trace metals is the most important aetiology for lung cancer. Selected essential/toxic metals (Ca, Mg, Na, K, Fe, Zn, Cu, Sr, Li, Co, Mn, Ni, Cr, Cd and Pb) are measured in the scalp hair and nails of lung cancer patients and controls by atomic absorption spectrophotometric method employing nitric acid-perchloric acid-based wet digestion. Average concentrations of Pb, Cd, Mn, Co and Cu are found to be significantly higher (p < 0.05) in the scalp hair and nails of lung cancer patients compared with the controls, however, appreciably higher concentrations of Zn, Ca, Na, Mg and Cr are noted in the scalp hair of the controls. Most of the metal levels reveal higher dispersion and asymmetry in the scalp hair/nails of the patients compared with the controls. Average metal levels are also compared to investigate probable differences based on sex, abode, food and smoking habits. The correlation study shows significantly diverse mutual variations of the metals in the scalp hair and nails of the patients and controls. Considerable variations in the metal levels are also noted for various stages and types of lung cancer (adenocarcinoma, squamous cell carcinoma, large cell carcinoma and small cell lung cancer). Multivariate apportionment of the metals in the scalp hair and nails of the patients and controls are also significantly diverse. The study reveals considerably divergent variations in the metal levels in lung cancer patients in comparison with healthy subjects.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
authors.forename: Muhammad Abdul
authors.initials: MA
authors.lastname: Qayyum
authors.forename: Munir H
authors.initials: MH
authors.lastname: Shah
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008670:Metals / Q000032:analysis*; D008875:Middle Aged; D015999:Multivariate Analysis; D009262:Nails / Q000737:chemistry*; D012535:Scalp; D013054:Spectrophotometry, Atomic; D055815:Young Adult
chemical_list: D008670:Metals