title: Roseola infantum and its causal human herpesviruses.
abstract: Roseola infantum, also known as exanthem subitum or sixth disease, is a generally benign febrile exanthem of infancy. It has a characteristic clinical course of high fever followed by the appearance of an exanthem upon defervescence. Febrile seizures are a frequent complication. Roseola is caused by infection with human herpesviruses 6 or 7 (HHV-6/7), which are acquired at a young age. Diagnosis is made by serology or by virus detection in body fluids and tissues. Treatment of roseola is supportive; recovery is usually complete with no significant sequelae. However, HHV-6/7 can reactivate in immunocompetent as well as immunocompromised individuals with severe systemic consequence.
authors.forename: Rivka C
authors.initials: RC
authors.lastname: Stone
authors.forename: Giuseppe A
authors.initials: GA
authors.lastname: Micali
authors.forename: Robert A
authors.initials: RA
authors.lastname: Schwartz
mesh_terms: D003937:Diagnosis, Differential; D005077:Exanthema Subitum / Q000821:virology*; D005334:Fever / Q000821:virology; D015654:Herpesvirus 6, Human; D016199:Herpesvirus 7, Human; D006801:Humans; D012640:Seizures / Q000821:virology