title: [Determinants of sensitivity to proteasome inhibitors and strategies to overcome acquired resistance to bortezomib in multiple myeloma].
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Iida
authors.forename: Masaki
authors.initials: M
authors.lastname: Ri
mesh_terms: D051700:Activating Transcription Factor 3; D051701:Activating Transcription Factor 4; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001897:Boronic Acids / Q000008:administration & dosage* / Q000494:pharmacology; D000069286:Bortezomib; D051360:Cyclin-Dependent Kinase 5; D016207:Cytokines; D004268:DNA-Binding Proteins; D003907:Dexamethasone / Q000008:administration & dosage; D055808:Drug Discovery; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006801:Humans; D006877:Hydroxamic Acids / Q000008:administration & dosage; D007211:Indoles / Q000008:administration & dosage; D051741:Kruppel-Like Transcription Factors; D058990:Molecular Targeted Therapy; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D054409:Nicotinamide Phosphoribosyltransferase; D009842:Oligopeptides / Q000008:administration & dosage; D000077767:Panobinostat; D010767:Phosphorylcholine / Q000008:administration & dosage / Q000031:analogs & derivatives; D061988:Proteasome Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D011719:Pyrazines / Q000008:administration & dosage* / Q000494:pharmacology; D000071701:Regulatory Factor X Transcription Factors; D014127:Toyocamycin / Q000008:administration & dosage; D014157:Transcription Factors
chemical_list: C490449:ATF3 protein, human; C497109:ATF4 protein, human; D051700:Activating Transcription Factor 3; D001897:Boronic Acids; D016207:Cytokines; D004268:DNA-Binding Proteins; D006877:Hydroxamic Acids; D007211:Indoles; C489676:KLF9 protein, human; D051741:Kruppel-Like Transcription Factors; D009842:Oligopeptides; C498702:PMAIP1 protein, human; D061988:Proteasome Inhibitors; D019253:Proto-Oncogene Proteins c-bcl-2; D011719:Pyrazines; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D010767:Phosphorylcholine; D051701:Activating Transcription Factor 4; C105905:perifosine; D000069286:Bortezomib; C524865:carfilzomib; D003907:Dexamethasone; D000077767:Panobinostat; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human; D051360:Cyclin-Dependent Kinase 5; C495905:CDK5 protein, human; D014127:Toyocamycin