title: Piceatannol attenuates cardiac hypertrophy in an animal model through regulation of the expression and binding of the transcription factor GATA binding factor 6.
abstract: Piceatannol is found in grapes, passion fruit, and Japanese knotweed. Piceatannol pretreatment suppresses cardiac hypertrophy induced by isoproterenol as assessed by heart weight/body weight ratio, cross-sectional area, and expression of hypertrophic markers. The anti-hypertrophic effect of piceatannol in rat neonatal cardiomyocytes is the same as that in vivo. Piceatannol inhibits lentiviral-GATA6-induced cardiomyocyte hypertrophy. Furthermore, piceatannol reduces the interaction between GATA4 and GATA6 as well as the DNA-binding activity of endogenous GATA6 in the ANP promoter. Our results suggest that piceatannol may be a novel therapeutic agent for the prevention of cardiac hypertrophy.
authors.affiliation: Heart Research Center of Chonnam National University Hospital, Gwangju 501-757, South Korea. Electronic address: sshjkee@hanmail.net.
authors.forename: Hae Jin
authors.initials: HJ
authors.lastname: Kee
authors.affiliation: Heart Research Center of Chonnam National University Hospital, Gwangju 501-757, South Korea.
authors.forename: Sangha
authors.initials: S
authors.lastname: Park
authors.affiliation: Heart Research Center of Chonnam National University Hospital, Gwangju 501-757, South Korea.
authors.forename: Wanseok
authors.initials: W
authors.lastname: Kang
authors.affiliation: Heart Research Center of Chonnam National University Hospital, Gwangju 501-757, South Korea.
authors.forename: Kyung Seob
authors.initials: KS
authors.lastname: Lim
authors.affiliation: Heart Research Center of Chonnam National University Hospital, Gwangju 501-757, South Korea.
authors.forename: Jung Ha
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Heart Research Center of Chonnam National University Hospital, Gwangju 501-757, South Korea.
authors.forename: Youngkeun
authors.initials: Y
authors.lastname: Ahn
authors.affiliation: Heart Research Center of Chonnam National University Hospital, Gwangju 501-757, South Korea. Electronic address: myungho@chollian.net.
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Jeong
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000188:drug therapy* / Q000473:pathology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D050991:GATA4 Transcription Factor / Q000378:metabolism; D050993:GATA6 Transcription Factor / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D057809:HEK293 Cells; D006801:Humans; D051379:Mice; D009206:Myocardium / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism; D061251:Primary Cell Culture; D011485:Protein Binding; D051381:Rats; D017207:Rats, Sprague-Dawley; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D002316:Cardiotonic Agents; D050991:GATA4 Transcription Factor; D050993:GATA6 Transcription Factor; C484171:Gata4 protein, mouse; C494760:Gata6 protein, mouse; D013267:Stilbenes; C041525:3,3',4,5'-tetrahydroxystilbene
keywords: Cardiomyocyte hypertrophy; GATA6; Piceatannol