title: Survivin and related proteins in canine mammary tumors: immunohistochemical expression.
abstract: Survivin is reexpressed in most human breast cancers, where its expression has been associated with tumor aggressiveness, poor prognosis, and poor response to therapy. Survivin expression was evaluated in 41 malignant canine mammary tumors (CMTs) by immunohistochemistry, in relation to histological grade and stage, and correlated with that of some related molecules (β-catenin, caspase 3, heat shock proteins) to understand their possible role in canine mammary tumorigenesis. An increase in nuclear survivin expression, compared with healthy mammary glands, was observed in CMTs, where nuclear immunolabeling was related to the presence of necrosis. No statistically significant relation was found between the expression of the investigated molecules and the histological grade or stage. The present study may suggest an important involvement of survivin in CMT tumorigenesis. Its overexpression in most of the cases evaluated might suggest that targeting survivin in CMTs may be a valid anticancer therapy.
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bongiovanni
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Romanucci
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Malatesta
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: D'Andrea
authors.affiliation: Faculty of Political Sciences, University of Teramo, Teramo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ciccarelli
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy ldellasalda@unite.it.
authors.forename: L
authors.initials: L
authors.lastname: Della Salda
mesh_terms: D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D063646:Carcinogenesis; D053148:Caspase 3 / Q000378:metabolism; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006360:Heat-Shock Proteins / Q000378:metabolism; D007150:Immunohistochemistry / Q000662:veterinary; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D015674:Mammary Neoplasms, Animal / Q000378:metabolism* / Q000473:pathology; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism
chemical_list: D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor; D006360:Heat-Shock Proteins; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D051176:beta Catenin; D053148:Caspase 3
keywords: caspase; dog; heat shock protein; mammary tumor; survivin; β-catenin