title: Chromosome 13 deletion and hypodiploidy on conventional cytogenetics are robust prognostic factors in Korean multiple myeloma patients: web-based multicenter registry study.
abstract: This study was designed to evaluate the prevalence of chromosomal abnormalities and to identify the specific abnormalities associated with poor prognosis. A total of 2,474 patients whose conventional cytogenetics were available at the time of diagnosis were evaluated via a nationwide registry. Normal metaphase cytogenetics was observed in 2,012 patients (81.3%). Among the 462 patients with chromosomal abnormalities, there were 161 (34.8%) patients with hyperdiploidy, 197 (42.6%) with pseudodiploidy, 79 (17.1%) with hypodiploidy, and 25 (5.5%) with near-tetraploidy. Deletion 13 (Δ13) in metaphase was observed in 167 patients (6.8%). Fluorescent in situ hybridization (FISH) was carried out in 967 patients (39.1%), and 66 (13.7%) out of 482 and 63 (10.3%) out of 611 patients were positive for t(4;14) and del(17p), respectively. With a median follow-up duration of 25.1 months, the median overall survival (OS) was 51.2 months (95% confidence interval, 46.5-55.9 months). In univariate analysis, the following four chromosomal abnormalities were significantly associated with a poor survival outcome: Δ13, hypodiploidy, del(13q) in FISH, and del(17p) in FISH. In the subsequent multivariate analysis, in which del(13q) and del(17p) in FISH were excluded due to a relatively low number of patients, Δ13 and hypodiploid status were independently associated with a poor survival outcome after adjusting for important clinical factors, including age, sex, performance, beta2-microglobulin, albumin, and lactate dehydrogenase (LDH). Using conventional metaphase cytogenetics, we confirmed that both Δ13 and hypodiploid status were robust poor prognostic factors. The metaphase karyotyping should remain the primary cytogenetic tool and an essential investigation for risk stratification in newly diagnosed multiple myeloma patients.
authors.affiliation: Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, South Korea.
authors.forename: Sukjoong
authors.initials: S
authors.lastname: Oh
authors.forename: Dong Hoe
authors.initials: DH
authors.lastname: Koo
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Kwon
authors.forename: Kihyun
authors.initials: K
authors.lastname: Kim
authors.forename: Cheolwon
authors.initials: C
authors.lastname: Suh
authors.forename: Chang-Ki
authors.initials: CK
authors.lastname: Min
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Yoon
authors.forename: Ho-Jin
authors.initials: HJ
authors.lastname: Shin
authors.forename: Deog-Yeon
authors.initials: DY
authors.lastname: Jo
authors.forename: Jae-Yong
authors.initials: JY
authors.lastname: Kwak
authors.forename: Jin Seok
authors.initials: JS
authors.lastname: Kim
authors.forename: Sang Kyun
authors.initials: SK
authors.lastname: Sohn
authors.forename: Young-Don
authors.initials: YD
authors.lastname: Joo
authors.forename: Hyeon-Seok
authors.initials: HS
authors.lastname: Eom
authors.forename: Sung-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Yang Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: ChulSoo
authors.initials: C
authors.lastname: Kim
authors.forename: Yeung-Chul
authors.initials: YC
authors.lastname: Mun
authors.forename: Hawk
authors.initials: H
authors.lastname: Kim
authors.forename: Dong Soon
authors.initials: DS
authors.lastname: Lee
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D001856:Bone Marrow Examination; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000235:genetics* / Q000401:mortality; D009194:Myeloma Proteins / Q000032:analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012042:Registries; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D009194:Myeloma Proteins