title: Cell microenvironment stimuli-responsive controlled-release delivery systems based on mesoporous silica nanoparticles.
abstract: To develop novel tumor cell microenvironment stimuli-responsive smart controlled-release delivery systems is one of the current common interests of materials science and clinical medicine. Meanwhile, mesoporous silica nanoparticles as a promising drug carrier have become the new area of interest in the field of biomedical application in recent years because of their unique characteristics and abilities to efficiently and specifically entrap cargo molecules. This review describes the more recent developments and achievements of mesoporous silica nanoparticles in drug delivery. In particular, we focus on the stimuli-responsive controlled-release systems that are able to respond to tumor cell environmental changes, such as pH, glucose, adenosine-5'-triphosphate (ATP), glutathione (GSH), and H(2)O(2).
authors.affiliation: Department of Chemistry, Fuzhou University, Fuzhou, PR China. Electronic address: clzhu@fzu.edu.cn.
authors.forename: Chun-Ling
authors.initials: CL
authors.lastname: Zhu
authors.affiliation: Department of Chemistry, Fuzhou University, Fuzhou, PR China.
authors.forename: Xian-Wei
authors.initials: XW
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Fuzhou University, Fuzhou, PR China.
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Fuzhou University, Fuzhou, PR China.
authors.forename: Zeng-Hong
authors.initials: ZH
authors.lastname: Xie
authors.affiliation: Xiamen Huaxia Vocational College, Wenjiao Aera, Jimei Xiamen, Fujian, PR China.
authors.forename: Xiao-Ru
authors.initials: XR
authors.lastname: Wang
mesh_terms: D000255:Adenosine Triphosphate; D060833:Cellular Microenvironment; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D005947:Glucose; D005978:Glutathione; D006801:Humans; D006861:Hydrogen Peroxide; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012822:Silicon Dioxide; D000255:Adenosine Triphosphate; D006861:Hydrogen Peroxide; D005978:Glutathione; D005947:Glucose
keywords: Cell environmentally responsive mechanisms; Controlled-release delivery system; Mesoporous silica nanoparticles; Stimuli-responsive