title: Nucleic acid based logical systems.
abstract: Researchers increasingly visualize a significant role for artificial biochemical logical systems in biological engineering, much like digital logic circuits in electrical engineering. Those logical systems could be utilized as a type of servomechanism to control nanodevices in vitro, monitor chemical reactions in situ, or regulate gene expression in vivo. Nucleic acids (NA), as carriers of genetic information with well-regulated and predictable structures, are promising materials for the design and engineering of biochemical circuits. A number of logical devices based on nucleic acids (NA) have been designed to handle various processes for technological or biotechnological purposes. This article focuses on the most recent and important developments in NA-based logical devices and their evolution from in vitro, through cellular, even towards in vivo biological applications.
authors.affiliation: Center for Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL (USA), Fax: (+1) 352-392-1679.
authors.forename: Da
authors.initials: D
authors.lastname: Han
authors.forename: Huaizhi
authors.initials: H
authors.lastname: Kang
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Cuichen
authors.initials: C
authors.lastname: Wu
authors.forename: Cuisong
authors.initials: C
authors.lastname: Zhou
authors.forename: Mingxu
authors.initials: M
authors.lastname: You
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zhang
authors.forename: Weihong
authors.initials: W
authors.lastname: Tan
mesh_terms: D000818:Animals; D001483:Base Sequence; D015374:Biosensing Techniques / Q000295:instrumentation; D039301:Computers, Molecular; D004867:Equipment Design; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D036103:Nanotechnology / Q000295:instrumentation; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry*
chemical_list: D009696:Nucleic Acids
keywords: DNA computation; DNA nanobiotechnology; logical systems; nucleic acids