title: Histology of a novel injectable filler (polymethylmethacrylate and cross-linked dextran in hydroxypropyl methylcellulose) in a rat model.
abstract: A novel injectable filler of polymethylmethacrylate (PMMA) and cross-linked dextran in hydroxypropyl methylcellulose was introduced in the commercial filler market. For soft tissue augmentation, safety and biocompatibility should be evaluated and the stability at the implantation site should be assessed using histologic evaluation. In order to evaluate the biocompatibility of the novel soft tissue filler, PMMA and cross-linked dextran in hydroxypropyl methylcellulose was subdermally injected into the skin of Sprague-Dawley Rats. Histologic evaluation was performed at 13 weeks and 12 months after the injection. Inflammatory cell infiltration, neovascularization, and fibrosis were scored according to defined grading systems. The mean score of the histologic evaluation was 5.7 and 3.9 at 13 weeks and 12 months, respectively. At 12 months after injection, the PMMA and cross-linked dextran in hydroxypropyl methylcellulose appeared to be kept in place through fine fibrous capsules. The mixture of PMMA and cross-linked dextran in hydroxypropyl methylcellulose can be safely applied for soft tissue augmentation with longevity of greater than 12 months.
authors.affiliation: Department of Dermatology, College of Medicine, Catholic University of Korea , Seoul , Republic of Korea.
authors.forename: Young Bok
authors.initials: YB
authors.lastname: Lee
authors.forename: Sae Mi
authors.initials: SM
authors.lastname: Park
authors.forename: Eun Jong
authors.initials: EJ
authors.lastname: Song
authors.forename: Jun-Gyu
authors.initials: JG
authors.lastname: Park
authors.forename: Kyoung-Oh
authors.initials: KO
authors.lastname: Cho
authors.forename: Jin Wou
authors.initials: JW
authors.lastname: Kim
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Yu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000009:adverse effects*; D003911:Dextrans / Q000008:administration & dosage / Q000009:adverse effects*; D005355:Fibrosis; D065347:Hypromellose Derivatives / Q000008:administration & dosage / Q000009:adverse effects*; D018655:Lymphocyte Count; D008264:Macrophages; D009389:Neovascularization, Pathologic / Q000139:chemically induced; D009504:Neutrophils; D019904:Polymethyl Methacrylate / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000098:blood supply / Q000187:drug effects / Q000473:pathology*
chemical_list: D001672:Biocompatible Materials; D003911:Dextrans; D065347:Hypromellose Derivatives; D019904:Polymethyl Methacrylate
keywords: dextran; filler; hydroxypropyl methylcellulose; polymethylmethacrylate