title: Oxidative stress regulation by DJ-1 in the retinal pigment epithelium.
abstract: DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson's Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.
authors.affiliation: Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, The Cole Eye Institute, i31, 9500 Euclid Avenue, 44195, Cleveland, OH, USA, bonilhav@ccf.org.
authors.forename: Vera L
authors.initials: VL
authors.lastname: Bonilha
authors.forename: Mary E
authors.initials: ME
authors.lastname: Rayborn
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yang
authors.forename: Chengsong
authors.initials: C
authors.lastname: Xie
authors.forename: Huaibin
authors.initials: H
authors.lastname: Cai
mesh_terms: D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008268:Macular Degeneration / Q000378:metabolism* / Q000473:pathology; D015513:Oncogene Proteins / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000378:metabolism*; D000071617:Protein Deglycase DJ-1; D055213:Retinal Pigment Epithelium / Q000378:metabolism* / Q000473:pathology
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1