title: The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity.
abstract: Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7 receptor (P2X7R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to modify CNS activity.
authors.affiliation: School of Chemistry, ‡Faculty of Health Science, §Discipline of Pharmacology, and ∥School of Psychology, Sydney University , NSW 2006, Australia.
authors.forename: Shane M
authors.initials: SM
authors.lastname: Wilkinson
authors.forename: Hendra
authors.initials: H
authors.lastname: Gunosewoyo
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Barron
authors.forename: Aurelie
authors.initials: A
authors.lastname: Boucher
authors.forename: Michelle
authors.initials: M
authors.lastname: McDonnell
authors.forename: Peter
authors.initials: P
authors.lastname: Turner
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Morrison
authors.forename: Maxwell R
authors.initials: MR
authors.lastname: Bennett
authors.forename: Iain S
authors.initials: IS
authors.lastname: McGregor
authors.forename: Louis M
authors.initials: LM
authors.lastname: Rendina
authors.forename: Michael
authors.initials: M
authors.lastname: Kassiou
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000627:therapeutic use*; D002490:Central Nervous System / Q000187:drug effects* / Q000378:metabolism; D003863:Depression / Q000188:drug therapy*; D006801:Humans; D011083:Polycyclic Compounds / Q000737:chemistry / Q000627:therapeutic use*; D058920:Purinergic P2X Receptor Antagonists / Q000627:therapeutic use*; D058486:Receptors, Purinergic P2X7 / Q000378:metabolism*
chemical_list: D000928:Antidepressive Agents; D011083:Polycyclic Compounds; D058920:Purinergic P2X Receptor Antagonists; D058486:Receptors, Purinergic P2X7