title: Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids.
abstract: The synthesis and evaluation of 3-enaminetetramic acids as antibacterial agents is reported; contrary to the analogous 3-acyltetramic acids, the enaminetetramic acid class of compound exhibits modest antibacterial activity against a limited spectrum of organisms, and even that activity is strongly dependent on the identity of the tetramate ring substituents. Moreover, these compounds appear to have a different mode of action to the analogous 3-acyltetramic acids, and appear to offer more limited opportunity for further elaboration in drug discovery.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, Mansfield Rd, Oxford OX1 3TA, UK.
authors.forename: Yong-Chul
authors.initials: YC
authors.lastname: Jeong
authors.affiliation: Chemistry Research Laboratory, University of Oxford, Mansfield Rd, Oxford OX1 3TA, UK.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Anwar
authors.affiliation: Chemistry Research Laboratory, University of Oxford, Mansfield Rd, Oxford OX1 3TA, UK. Electronic address: mark.moloney@chem.ox.ac.uk.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Moloney
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibacterial; Enamine; Tetramate