title: Bionic design for surface optimization combining hydrophilic and negative charged biological macromolecules.
abstract: While polyethersulfone (PES) membrane represents a promising option for blood purification, the blood compatibility must be dramatically enhanced to meet today's ever-increasing demands for many emerging application. In this study, we report a bionic design for optimization and development of a modified PES membrane combining hydrophilic and negative charged biological macromolecules on its surface. The hydrophilic and ionic charged biological macromolecules sulfonated poly(styrene)-b-poly(methyl methacrylate)-b-poly-(styrene) (PSSMSS) and poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly-(vinyl pyrrolidone) were synthesized via reversible addition-fragmentation chain transfer polymerization and used together to modify PES membranes by blending method. A hydrophilic membrane surface with negative charged surface coating was obtained, imitating the hydrophilic and negatively charged structure feature of heparin. The modified PES membranes showed suppressed platelet adhesion, and a prolonged blood clotting time, and thereby improved blood compatibility. In addition, the blood clotting time of the modified membranes increased with the blended PSSMSS amounts increment, indicating that both the hydrophilic and negative charged groups play important roles in improving the blood compatibility of PES membranes.
authors.affiliation: School of Material Science and Engineering, State Key Laboratory of Gansu Advanced Non-Ferrous Metal Materials, Lanzhou University of Technology, Lanzhou 730050, People's Republic of China. Electronic address: ranfen@163.com.
authors.forename: Fen
authors.initials: F
authors.lastname: Ran
authors.affiliation: School of Material Science and Engineering, State Key Laboratory of Gansu Advanced Non-Ferrous Metal Materials, Lanzhou University of Technology, Lanzhou 730050, People's Republic of China.
authors.forename: Haiming
authors.initials: H
authors.lastname: Song
authors.affiliation: College of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, People's Republic of China.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Niu
authors.affiliation: College of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, People's Republic of China.
authors.forename: Aimei
authors.initials: A
authors.lastname: Yang
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.
authors.forename: Shengqiang
authors.initials: S
authors.lastname: Nie
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.
authors.forename: Lingren
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Material Science and Engineering, State Key Laboratory of Gansu Advanced Non-Ferrous Metal Materials, Lanzhou University of Technology, Lanzhou 730050, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.
authors.forename: Shudong
authors.initials: S
authors.lastname: Sun
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China. Electronic address: zhaochsh70@163.com.
authors.forename: Changsheng
authors.initials: C
authors.lastname: Zhao
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001701:Bionics; D006493:Heparin / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D046911:Macromolecular Substances / Q000737:chemistry*; D008567:Membranes, Artificial; D011108:Polymers / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*; D013499:Surface Properties; D014914:Whole Blood Coagulation Time
chemical_list: D001672:Biocompatible Materials; D046911:Macromolecular Substances; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C022840:polyether sulfone; D006493:Heparin
keywords: Amphiphilic triblock copolymer; Blood compatibility; Polyethersulfone membrane; Surface modification