title: [Bone and Stem Cells. Mesenchymal stem cells and bone regeneration].
abstract: Mesenchymal stem cells (MSCs) have multi-differentiation potency, and enhance wound healing in various kinds of disease. Recently MSC not only differentiate into tissue-forming cells, but also secrete various kinds of cytokines and chemokines that are anti-apoptotic, immunomodulatory, angiogenic, and the cell-mobilizing to influence extracellular environment. In addition, we show that MSC has a novel intercellular communication mechanism. It hopes to suggest ways to make safer and reliable usage of MSC in bone regeneration.
authors.affiliation: Tokyo Medical and Dental University Graduate School of Medeical and Dentai Science, Department of Nanomedicine (DNP) , Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Komaki
authors.forename: Kengo
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Ikuo
authors.initials: I
authors.lastname: Morita
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D002450:Cell Communication; D002454:Cell Differentiation / Q000502:physiology*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology*