title: Influence of interleukin-15 polymorphism on the survival of adult patients with acute lymphoblastic leukemia in Egypt.
abstract: The aim of this study was to analyze the association of the rs10519612 and rs17007695 polymorphisms with the risk of acute lymphoblastic leukemia (ALL) and also to evaluate their impact on the survival of adult patients with ALL. The study included 164 adult patients with ALL and 158 healthy subjects as a control group who were genotyped for the interleukin-15 (IL-15) gene using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. We observed a higher risk of developing ALL for rs10519612 CC, rs17007695 TC and rs17007695 CC genotype carriers. There was increased risk for T-cell type in patients with the rs10519612 CC genotype. Notably, increased risk to develop B-cell type was found with rs17007695 TC and CC genotypes. There was no impact on overall survival or disease-free survival at 3 years. It is concluded that there is an association between both gene polymorphisms and the risk of ALL and with disease immunophenotype. However, there was no impact on the outcome of patients.
authors.affiliation: Clinical Pathology Department, Faculty of Medicine, Mansoura University , Mansoura , Egypt.
authors.forename: Rabab M
authors.initials: RM
authors.lastname: Aly
authors.forename: Mona M
authors.initials: MM
authors.lastname: Taalab
authors.forename: Hayam F
authors.initials: HF
authors.lastname: Ghazy
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004534:Egypt; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D019409:Interleukin-15 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000401:mortality*; D011379:Prognosis
chemical_list: D019409:Interleukin-15
keywords: ALL; IL-15; polymorphism; survival