title: Hypertriglyceridemic waist phenotype and chronic kidney disease in a Chinese population aged 40 years and older.
abstract: OBJECTIVE
  To examine the relationship between the HW phenotype and risk for CKD in a community population aged 40 years and older.
  
  
  METHODS
  A cross-sectional study was conducted in Zhuhai from June to October 2012. The participants were divided into three groups: Group 1, Waist circumference >90 cm in men or >85 cm in women and triglycerides ≥2 mmol/l; Group 3, Waist circumference ≤90 cm in men or ≤85 cm in women and triglycerides <2 mmol/l; Group 2, The remaining participants. The prevalence of the three subgroups and CKD were determined. The association between HW phenotype and CKD was then analyzed using SPSS (version 13.0).
  
  
  RESULTS
  After adjusting for age and sex, Group 1 was associated with CKD (OR 3.08, 95% CI 2.01, 4.73, P<0.001), when compared with Group 3. Further adjustment for factors which were potential confounders and unlikely to be in the causal pathway between the HW phenotype and CKD, Group 1 was still significantly associated with CKD. The OR for CKD was 2.65 (95% CI 1.65, 4.26, P<0.001). When adjusted for diabetes and hypertension, the association of Group 1 and CKD was still significant (OR 2.09, 95% CI 1.26, 3.45, P = 0.004). Group 2 was associated with CKD (OR 1.81, 95% CI 1.29, 2.53, P = 0.001), when compared with Group 3. Further adjustment for factors which were potential confounders, Group 2 was still significantly associated with CKD. The OR for CKD was 1.75 (95% CI 1.22, 2.51, P = 0.002). When adjusted for diabetes and hypertension, the association between Group 2 and CKD still existed. The OR for CKD was 1.48 (95% CI 1.01, 2.16, P = 0.046).
  
  
  CONCLUSIONS
  Our results showed that HW phenotype was associated with CKD in the population aged 40 years and older.
authors.affiliation: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Chaomin
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Shao
authors.affiliation: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Honglei
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Kangping
authors.initials: K
authors.lastname: Deng
authors.affiliation: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Liu
authors.affiliation: National Centre for Sensor Research/BioAnalytical Sciences, Dublin City University, Dublin, Ireland.
authors.forename: Harry
authors.initials: H
authors.lastname: Holthöfer
authors.affiliation: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Hequn
authors.initials: H
authors.lastname: Zou
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D064250:Hypertriglyceridemic Waist / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000453:epidemiology*; D012111:Residence Characteristics / Q000706:statistics & numerical data