title: Can treatment of nocturia increase testosterone level in men with late onset hypogonadism?
abstract: OBJECTIVE
  To assess the effect of desmopressin on serum testosterone level in men with nocturia and late onset hypogonadism.
  
  
  METHODS
  We prospectively enrolled men with nocturia and symptoms of late onset hypogonadism. Desmopressin (0.1 mg) was administered once daily to patients for 12 weeks, and we then compared serum testosterone levels, electrolytes, frequency volume chart indices, and changes in the International Prostate Symptom Score (IPSS), International Index of Erectile Function, and Aging Male's Symptom scales before and after treatment. Patients with a history of cardiovascular disease or hyponatremia, those using hypnotics, and those who had primary hypogonadism or hypogonadotrophic hypogonadism were excluded from the study.
  
  
  RESULTS
  Sixty-two men (mean age, 68.4 years) completed pre- and post-treatment questionnaires and underwent laboratory testing. At the end of the study, the testosterone levels in men with low testosterone levels (<3.5 ng/mL) increased after the 12-week desmopressin treatment (2.85 ± 0.58 to 3.97 ± 1.44 ng/mL; P = .001). Mean scores had decreased from 17.7 to 13.9 (IPSS), 3.8 to 3.2 (IPSS-Quality of Life), and 33.7 to 31.1 (Aging Male's Symptom). On the frequency volume chart, nocturnal urine volume, nocturnal polyuria index, actual number of nocturia events, nocturia index, and nocturnal bladder capacity index were significantly decreased.
  
  
  CONCLUSIONS
  Desmopressin improved nocturia and other urinary symptoms. Moreover, serum testosterone levels increased significantly in men with low testosterone levels after 12-week desmopressin treatment.
authors.affiliation: Korea University Medical Center, Seoul, Republic of Korea.
authors.forename: Jong Wook
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Korea University Medical Center, Seoul, Republic of Korea.
authors.forename: Ji Yun
authors.initials: JY
authors.lastname: Chae
authors.affiliation: Korea University Medical Center, Seoul, Republic of Korea.
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Korea University Medical Center, Seoul, Republic of Korea.
authors.forename: Cheol Yong
authors.initials: CY
authors.lastname: Yoon
authors.affiliation: Korea University Medical Center, Seoul, Republic of Korea.
authors.forename: Mi Mi
authors.initials: MM
authors.lastname: Oh
authors.affiliation: Korea University Medical Center, Seoul, Republic of Korea.
authors.forename: Hong Seok
authors.initials: HS
authors.lastname: Park
authors.affiliation: Korea University Medical Center, Seoul, Republic of Korea.
authors.forename: Je Jong
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Korea University Medical Center, Seoul, Republic of Korea. Electronic address: dgmoon@korea.ac.kr.
authors.forename: Du Geon
authors.initials: du G
authors.lastname: Moon
mesh_terms: D000368:Aged; D000375:Aging; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D004573:Electrolytes / Q000378:metabolism; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000150:complications / Q000188:drug therapy*; D010410:Penile Erection; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood*
chemical_list: D004573:Electrolytes; D013739:Testosterone; D003894:Deamino Arginine Vasopressin