title: Increased levels of circulating advanced glycation end-products in menopausal women with osteoporosis.
abstract: BACKGROUND
  Advanced glycation end-products (AGEs) can accumulate in organs and tissues during ageing and diabetes. Increased levels of AGEs are found in the bone tissue of patients with osteoporosis. The purpose of this study was to evaluate circulating AGEs in patients with osteoporosis.
  
  
  METHODS
  We evaluated plasma AGEs, osteoporosis-related biomarkers, and bone mass in 82 menopausal women with osteoporosis or osteopenia, 16 young women with osteopenia, and 43 healthy women without osteoporosis or osteopenia.
  
  
  RESULTS
  Higher levels of serum AGEs were found in the osteoporosis or osteopenia group compared to healthy women (P < 0.0001). A negative correlation was observed between serum AGEs and lumbar spine bone density (BMD of lumbar spine, r = -0.249, P = 0.028; T-score of lumbar spine, r = -0.261, P = 0.021). Women with a increased level of serum AGEs (> 8.12 U/mL) had a 5.34-fold risk of osteopenia regarding lumbar spine T-score and a 3.31-fold risk of osteopenia regarding the hip T-score.
  
  
  CONCLUSIONS
  Serum AGEs could be used to monitor the severity and progression of osteoporosis. An increased serum level of AGEs was associated with impaired bone formation and was a risk factor for the development of osteoporosis. Targeting AGEs may represent a novel therapeutic approach for primary or secondary osteoporosis.
authors.affiliation: 1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; ; 2. Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Taichung Armed-Forces General Hospital, Taichung, Taiwan;
authors.forename: Deng-Ho
authors.initials: DH
authors.lastname: Yang
authors.affiliation: 3. Department of Orthopedic Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan; ; 4. Department of Nursing, College of Medicine & Nursing, Hung Kuang University, Taichung, Taiwan;
authors.forename: Tsay-I
authors.initials: TI
authors.lastname: Chiang
authors.affiliation: 3. Department of Orthopedic Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan; ; 5. School of Medicine, Chung Shan Medical University, Taichung, Taiwan;
authors.forename: I-Chang
authors.initials: IC
authors.lastname: Chang
authors.affiliation: 6. School of Public Health, National Defense Medical Center, Taipei, Taiwan;
authors.forename: Fu-Huang
authors.initials: FH
authors.lastname: Lin
authors.affiliation: 1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; ; 7. Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung Taiwan;
authors.forename: Cheng-Chung
authors.initials: CC
authors.lastname: Wei
authors.affiliation: 1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; ; 8. Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Cheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000235:genetics; D001851:Bone Diseases, Metabolic / Q000097:blood* / Q000473:pathology; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000473:pathology
chemical_list: D017127:Glycation End Products, Advanced; D053495:Osteopontin
keywords: Advanced glycation end-products; Biomarker; Osteopenia; Osteopontin.; Osteoporosis