title: [Effect of casein osphopeptide-amorphous calcium phosphate solution in preventing enamel demineralization].
abstract: OBJECTIVE
  To evaluate the effects of casein osphopeptide-amorphous calcium phosphate (CPP-ACP) in preventing enamel demineralization.
  
  
  METHODS
  Enamel blocks were prepared from premolars extracted from orthodontic patients. The specimens were treated for 30 min daily for 7 days with one of the following agents: deionized water (negative control), CPP-ACP paste, and NaF solutions (positive controls) (0.2% and 2%). After the treatments, the specimens were immersed in a demineralizing solution (pH 4.5) for 7 days. The morphology and depth of the lesion were observed using scanning electron microscopy, and the content of Ca, P, Mg in the demineralized enamel was measured by electron probe micro-analyzer.
  
  
  RESULTS
  The demineralization rates in all the treatment groups were significantly smaller than those in the control group after 7 days of demineralization.
  
  
  CONCLUSIONS
  The application of CPP-ACP to the enamel surfaces can inhibit enamel demineralization with an equivalent effect to 0.2% NaF.
authors.affiliation: Department of Stomatology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China. E-mail: long_bj2008@163.com.
authors.forename: Baojun
authors.initials: B
authors.lastname: Long
authors.forename: Ke
authors.initials: K
authors.lastname: Chen
authors.forename: Dongjie
authors.initials: D
authors.lastname: Zhang
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Li
mesh_terms: D000293:Adolescent; D002364:Caseins / Q000627:therapeutic use*; D003743:Dental Enamel; D006801:Humans; D012969:Sodium Fluoride; D017001:Tooth Demineralization / Q000517:prevention & control*; D014089:Tooth Remineralization
chemical_list: D002364:Caseins; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D012969:Sodium Fluoride