title: Hemi body irradiation: An economical way of palliation of pain in bone metastasis in advanced cancer.
abstract: BACKGROUND
  The primary aim of this prospective non-randomized study was to evaluate the effect of hemi-body irradiation (HBI) on pain and quality of life in cancer patients with extensive bone metastases. The secondary aim was to evaluate side-effects and cost-effectiveness of the treatment.
  
  
  METHODS
  Between March 2008 and December 2010, a total of 23 (male = 14, female = 9, median age = 60 years) diagnosed cases of metastatic cancer patients (prostate = 11, breast = 6, and lung = 6) received HBI, which was delivered as lower (n = 7) (dose = 8 Gy), upper (n = 8) (dose = 6 Gy), or sequential HBI (n = 8) with a Telecobalt unit (Theratron 780C). Among them, one lung cancer patient died at 2 months and one prostate cancer patient defaulted after the second follow-up. Thus, 21 patients (male = 13, female = 8, median age = 65 years) (prostatic cancer = 10, breast cancer = 6, and lung cancer = 5) were followed up for a minimum of 6 months. Evaluations were performed before and at 2, 4, 8, 16, and 24 weeks after treatment. Pain evaluation was done by Visual Analogue Scale (VAS), Verbal Rating Scale (VRS), Percentage of Pain Relief (PRR), and Global Pain Score (GPS). Toxicity was assessed by CTC v-3 toxicity scores in the medical record. Assessment of oral morphine consumption was done before and after radiation using paired t-test, and correlation analysis was also done with decrease of morphine consumption and reduction of pain score using statistical analysis.
  
  
  RESULTS
  Response (control of pain) was partial (PR) in 67% and complete (CR) in 22% of patients. For most patients, the pain control lasted throughout the follow-up period (6 months). From 66.66% patients requiring 13 or more Morphine (10 mg) tablets per day prior to HBI, none of the patients required to consume 13 or more Morphine (10 mg) tablets per day following HBI, which was correlated with significant reduction in various pain scores (P < 0.05). One way ANOVA with Dunnett's Multiple Comparison Test (P < 0.05) was significant in VAS score changes, VRS score changes, PPR score changes, and GPS score changes. Along with the decrease in morphine tablets, the Linear Correlation of various scales for pain reduction like VAS, VRS, PPR, and GPS were significant. As such, the quality of life was better due to decreased pain and also, a decrease in the dose of analgesics. Grade 1 and 2 hematological toxicity and grade 1 diarrhea were observed as common side-effects. The average total cost of treatment including hospital stay, medicines, and radiation charges was around INR 400.00.
  
  
  CONCLUSIONS
  This study shows that hemibody irradiation is not only an effective modality for palliation of severe bone pain in advanced cancer cases but also economical, involves short hospital stay, with acceptable side-effects, utilizes the simple Telecobalt machine, and is less cumbersome in comparison to other currently available pain palliation methods like oral morphine and radiopharmaceuticals.
authors.affiliation: Department of Radiotherapy, Medical College, Siliguri, India.
authors.forename: Santanu
authors.initials: S
authors.lastname: Pal
authors.affiliation: Department of Radiotherapy, North Bengal Medical College, Siliguri, India.
authors.forename: Samrat
authors.initials: S
authors.lastname: Dutta
authors.affiliation: Department of Radiotherapy, Medical College, Siliguri, India.
authors.forename: Shyam Sundar
authors.initials: SS
authors.lastname: Adhikary
authors.affiliation: Department of Radiotherapy, Medical College, Siliguri, India.
authors.forename: Biswamit
authors.initials: B
authors.lastname: Bhattacharya
authors.affiliation: Department of Pharmacology, Medical College, Kolkata, West Bengal, India.
authors.forename: Balaram
authors.initials: B
authors.lastname: Ghosh
authors.affiliation: Department of Radiotherapy, Medical College, Siliguri, India.
authors.forename: Niladri B
authors.initials: NB
authors.lastname: Patra
keywords: Bone metastasis; hemibody irradiation; pain; palliation