title: Contrast-induced nephropathy in aged critically ill patients.
abstract: BACKGROUND
  Aging is associated with renal structural changes and functional decline. The attributable risk for renal dysfunction from radiocontrast agents in critically ill older patients has not been well established.
  
  
  METHODS
  In this prospective study, we assessed the incidence of contrast-induced nephropathy (CIN) in critically ill patients with stable renal function who underwent computed tomography with intravenous contrast media. Patients were categorized into two age groups: <65 (YG) or ≥ 65 years old (OG). CIN was defined as 25% or greater increase from baseline of serum creatinine or as an absolute increase by 0.5 mg/dL until the 5th day after the infusion of contrast agent. We also evaluated the alterations in oxidative stress by assessing serum 8-isoprostane.
  
  
  RESULTS
  CIN occurred in 5 of 13 OG patients (38.46%) whereas no YG patient presented CIN (P = 0.015). Serum creatinine kinetics in older patients demonstrated a rise over five days following contrast infusion time while a decline was observed in the YG (P = 0.005).
  
  
  CONCLUSIONS
  Older critically ill patients are more prone to develop renal dysfunction after the intravenous infusion of contrast agent in relation to their younger counterparts.
authors.affiliation: Department of Critical Care, Surgical Department, University Hospital of Larissa, Biopolis, 41110 Larissa, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Palli
authors.affiliation: Department of Critical Care, Surgical Department, University Hospital of Larissa, Biopolis, 41110 Larissa, Greece.
authors.forename: Demosthenes
authors.initials: D
authors.lastname: Makris
authors.affiliation: Department of Critical Care, Surgical Department, University Hospital of Larissa, Biopolis, 41110 Larissa, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Papanikolaou
authors.affiliation: Department of Critical Care, Surgical Department, University Hospital of Larissa, Biopolis, 41110 Larissa, Greece.
authors.forename: Grigorios
authors.initials: G
authors.lastname: Garoufalis
authors.affiliation: Department of Critical Care, Surgical Department, University Hospital of Larissa, Biopolis, 41110 Larissa, Greece.
authors.forename: Epaminondas
authors.initials: E
authors.lastname: Zakynthinos
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood / Q000473:pathology*; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D016638:Critical Illness; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology*; D008297:Male; D014508:Urea / Q000097:blood
chemical_list: D003287:Contrast Media; C075750:8-epi-prostaglandin F2alpha; D014508:Urea; D003404:Creatinine; D015237:Dinoprost