title: Pd(II)-catalyzed intermolecular arylation of unactivated C(sp3)-H bonds with aryl bromides enabled by 8-aminoquinoline auxiliary.
abstract: An example of using readily available, less reactive aryl bromides as arylating reagents in the Pd(II)-catalyzed intermolecular arylation of unactivated C(sp(3))-H bonds is described. This reaction was promoted by a crucial 8-aminoquinolinyl directing group and a K2CO3 base, enabling regiospecific installation of an aryl scaffold at the β-position of carboxamides. A mechanistic study by DFT calculations reveals a C(sp(3))-H activation-led pathway featuring the oxidative addition as the highest energy transition state.
authors.affiliation: Center for Organic Chemistry and Materials Physics Center, Frontier Institute of Science and Technology, ‡School of Materials Science and Engineering, Xi'an Jiaotong University , Xi'an, Shaanxi, 710054, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wei
authors.forename: Huarong
authors.initials: H
authors.lastname: Tang
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Cong
authors.forename: Bin
authors.initials: B
authors.lastname: Rao
authors.forename: Chao
authors.initials: C
authors.lastname: Wu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zeng