title: Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis.
abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disease which leads to destruction of joints. Current treatment modalities for RA either produce symptomatic relief (NSAIDs) or modify the disease process (DMARDs). Though effective, their use is also limited by their side effects. As a result, the interest in alternative, well tolerated anti-inflammatory remedies has re-emerged. Our aim was to evaluate the antioxidant and antiarthritic activity of Boswellia serrata gum resin extract (BSE) in collagen induced arthritis. Arthritis was induced in male Wistar rats by collagen induced arthritis (CIA) method. BSE was administered at doses of 100 and 200mg/kg body weight once daily for 21 days. The effects of treatment in the rats were assessed by biochemical (articular elastase, MPO, LPO, GSH, catalase, SOD and NO), inflammatory mediators (IL-1β, IL-6, TNF-α, IL-10, IFN-γ and PGE2), and histological studies in joints. BSE was effective in bringing significant changes on all the parameters (articular elastase, MPO, LPO, GSH, catalase, SOD and NO) studied. Oral administration of BSE resulted in significantly reduced levels of inflammatory mediators (IL-1β, IL-6, TNF-α, IFN-γ and PGE2), and increased level of IL-10. The protective effects of BSE against RA were also evident from the decrease in arthritis scoring and bone histology. The abilities to inhibit proinflammatory cytokines and modulation of antioxidant status suggest that the protective effect of Boswellia serrata extract on arthritis in rats might be mediated via the modulation of immune system.
authors.affiliation: Clinical Toxicology Laboratory, Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, India; Department of Biotechnology, Jamia Millia Islamia, New Delhi 110025, India. Electronic address: sadiq36@gmail.com.
authors.forename: Sadiq
authors.initials: S
authors.lastname: Umar
authors.affiliation: Department of Chemistry, Aligarh Muslim University, Aligarh, U.P. 200202, India.
authors.forename: Khalid
authors.initials: K
authors.lastname: Umar
authors.affiliation: CIRBSc, Jamia Millia Islamia, New Delhi 110025, India.
authors.forename: Abu Hasnath Md Golam
authors.initials: AH
authors.lastname: Sarwar
authors.affiliation: Research Centre, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Altaf
authors.initials: A
authors.lastname: Khan
authors.affiliation: Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi 110062, India.
authors.forename: Niyaz
authors.initials: N
authors.lastname: Ahmad
authors.affiliation: Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi 110062, India.
authors.forename: Sayeed
authors.initials: S
authors.lastname: Ahmad
authors.affiliation: Ayurvedic Research Lab., Dabur Research Centre, Ghaziabad, U.P. 201010, India.
authors.forename: Chandra Kant
authors.initials: CK
authors.lastname: Katiyar
authors.affiliation: Department of Biotechnology, Jamia Millia Islamia, New Delhi 110025, India.
authors.forename: Syed Akhtar
authors.initials: SA
authors.lastname: Husain
authors.affiliation: Clinical Toxicology Laboratory, Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, India. Electronic address: halitox@gmail.com.
authors.forename: Haider A
authors.initials: HA
authors.lastname: Khan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000097:blood / Q000188:drug therapy*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D029743:Boswellia; D003094:Collagen; D016207:Cytokines / Q000097:blood; D007249:Inflammation / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D017208:Rats, Wistar; D012116:Resins, Plant
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D018501:Antirheumatic Agents; D016207:Cytokines; D018836:Inflammation Mediators; D010936:Plant Extracts; D012116:Resins, Plant; D003094:Collagen
keywords: Boswellia serrata; Collagen induced arthritis; Cytokines; PGE(2)