title: Functional adaptation of bovine mesenteric lymphatic vessels to mesenteric venous hypertension.
abstract: Lymph flow is the primary mechanism for returning interstitial fluid to the blood circulation. Currently, the adaptive response of lymphatic vessels to mesenteric venous hypertension is not known. This study sought to determine the functional responses of postnodal mesenteric lymphatic vessels. We surgically occluded bovine mesenteric veins to create mesenteric venous hypertension to elevate mesenteric lymph flow. Three days after surgery, postnodal mesenteric lymphatic vessels from mesenteric venous hypertension (MVH; n = 7) and sham surgery (Sham; n = 6) group animals were evaluated and compared. Contraction frequency (MVH: 2.98 ± 0.75 min(-1); Sham: 5.42 ± 0.81 min(-1)) and fractional pump flow (MVH: 1.14 ± 0.30 min(-1); Sham: 2.39 ± 0.32 min(-1)) were significantly lower in the venous occlusion group. These results indicate that postnodal mesenteric lymphatic vessels adapt to mesenteric venous hypertension by reducing intrinsic contractile activity.
authors.affiliation: Michael E. DeBakey Institute, Texas A&M University, College Station, Texas; Department of Biomedical Engineering, Texas A&M University, College Station, Texas; cquick@tamu.edu.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Quick
authors.affiliation: Michael E. DeBakey Institute, Texas A&M University, College Station, Texas; Department of Biomedical Engineering, Texas A&M University, College Station, Texas;
authors.forename: John C
authors.initials: JC
authors.lastname: Criscione
authors.affiliation: Department Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada;
authors.forename: Akhilesh
authors.initials: A
authors.lastname: Kotiya
authors.affiliation: Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;
authors.forename: Ranjeet M
authors.initials: RM
authors.lastname: Dongaonkar
authors.affiliation: Michael E. DeBakey Institute, Texas A&M University, College Station, Texas; Large Animal Clinical Sciences, Texas A&M University, College Station, Texas; and.
authors.forename: Joanne
authors.initials: J
authors.lastname: Hardy
authors.affiliation: Michael E. DeBakey Institute, Texas A&M University, College Station, Texas; Systems Biology and Translational Medicine, Texas A&M Health Science Center, Temple, Texas.
authors.forename: Emily
authors.initials: E
authors.lastname: Wilson
authors.affiliation: Michael E. DeBakey Institute, Texas A&M University, College Station, Texas; Systems Biology and Translational Medicine, Texas A&M Health Science Center, Temple, Texas.
authors.forename: Anatoliy A
authors.initials: AA
authors.lastname: Gashev
authors.affiliation: Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;
authors.forename: Glen A
authors.initials: GA
authors.lastname: Laine
authors.affiliation: Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;
authors.forename: Randolph H
authors.initials: RH
authors.lastname: Stewart
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D002417:Cattle / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D006973:Hypertension / Q000503:physiopathology*; D008196:Lymph / Q000502:physiology; D008208:Lymphatic System / Q000502:physiology; D042601:Lymphatic Vessels / Q000502:physiology*; D008642:Mesenteric Veins / Q000503:physiopathology; D008643:Mesentery / Q000502:physiology*; D008833:Microcirculation / Q000502:physiology; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000502:physiology
keywords: interstitial fluid; lymph flow; lymphangion; postnodal lymphatic vessels