title: Role of G protein-coupled receptor kinases in cell migration.
abstract: G protein-coupled receptor kinases (GRKs) are emerging as important integrative nodes in cell migration processes. Recent evidence links GRKs (particularly the GRK2 isoform) to the complex modulation of diverse aspects of cell motility. In addition to its well-established role in the desensitization of G protein-coupled receptors involved in chemotaxis, GRK2 can play an effector role in the organization of actin and microtubule networks and in adhesion dynamics, by means of novel substrates and transient interacting partners, such as the GIT1 scaffold or the cytoplasmic α-tubulin deacetylase histone deacetylase 6 (HDAC6). The overall effect of altering GRK levels or activity on chemotaxis would depend on how such different roles are integrated in a given cell type and physiological context, and may have relevant implications in inflammatory diseases or cancer progression.
authors.affiliation: Departamento de Biología Molecular and Centro de Biología Molecular "Severo Ochoa" (Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid), Universidad Autónoma de Madrid, 28049 Madrid, Spain; Instituto de Investigación Sanitaria La Princesa, 28006 Madrid, Spain.
authors.forename: Petronila
authors.initials: P
authors.lastname: Penela
authors.affiliation: Departamento de Biología Molecular and Centro de Biología Molecular "Severo Ochoa" (Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid), Universidad Autónoma de Madrid, 28049 Madrid, Spain; Instituto de Investigación Sanitaria La Princesa, 28006 Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Nogués
authors.affiliation: Departamento de Biología Molecular and Centro de Biología Molecular "Severo Ochoa" (Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid), Universidad Autónoma de Madrid, 28049 Madrid, Spain; Instituto de Investigación Sanitaria La Princesa, 28006 Madrid, Spain. Electronic address: fmayor@cbm.uam.es.
authors.forename: Federico
authors.initials: F
authors.lastname: Mayor
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D016764:Cell Polarity; D048430:Cell Shape; D002633:Chemotaxis; D022001:Focal Adhesions; D054769:G-Protein-Coupled Receptor Kinase 2 / Q000378:metabolism; D054768:G-Protein-Coupled Receptor Kinases / Q000378:metabolism*; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000473:pathology; D009369:Neoplasms / Q000473:pathology; D010766:Phosphorylation; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D014404:Tubulin / Q000378:metabolism
chemical_list: D043562:Receptors, G-Protein-Coupled; D014404:Tubulin; D054769:G-Protein-Coupled Receptor Kinase 2; D054768:G-Protein-Coupled Receptor Kinases; D006655:Histone Deacetylases