title: Integrated approaches to understanding antipsychotic drug action at GPCRs.
abstract: The G-protein coupled receptor (GPCR) family of genes represents one of the largest druggable families of genes in the human genome. This is evident by the fact that approximately 30% of currently marketed drugs target GPCRs. However, many of these drugs are limited in their clinical potential as they are associated with debilitating side effects-a consequence of our incomplete understanding of their pharmacology and the signaling pathways regulated by GPCRs. Because of the limited range of tools available to resolve these issues, integrated approaches are required to fully understand the pharmacological action of drugs and the biochemical repertoire regulated by GPCRs. In this review we will focus on the action of antipsychotic drugs on certain monoamine GPCRs in the central nervous system (CNS) and the approaches being developed to elucidate their distinct pharmacology.
authors.affiliation: Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, United States.
authors.forename: Nikhil M
authors.initials: NM
authors.lastname: Urs
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, United States.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Nicholls
authors.affiliation: Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, United States; Department of Medicine, Neurobiology, Duke University Medical Center, Durham, NC 27710, United States. Electronic address: m.caron@cellbio.duke.edu.
authors.forename: Marc G
authors.initials: MG
authors.lastname: Caron
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D006801:Humans; D040901:Proteomics; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D059467:Transcriptome
chemical_list: D014150:Antipsychotic Agents; D043562:Receptors, G-Protein-Coupled