title: Anti-ulcer xanthones from the roots of Hypericum oblongifolium Wall.
abstract: Three new xanthones, hypericorin C (1), hypericorin D (2) and 3,4-dihydroxy-5-methoxyxanthone (3), along with eight known compounds; 2,3-dimethoxyxanthone (4), 3,4-dihydroxy-2-methoxyxanthone (5), 3,5-dihydroxy-1-methoxyxanthone (6), 3-acetylbetulinic acid (7), 10H-1,3-dioxolo[4,5-b]xanthen-10-one (8), 3-hydroxy-2-methoxyxanthone (9), 3,4,5-trihydroxyxanthone (10) and betulinic acid (11) were isolated from the roots of Hypericum oblongifolium. The structures of the new compounds 1, 2 and 3 were deduced by spectroscopic techniques [ESI MS, (1)H NMR, (13)C NMR, and 2D NMR (HMQC, HMBC, COSY and NOESY)]. The entire series of compounds were evaluated for anti-ulcer activity.
authors.affiliation: Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan. Electronic address: mumtazphd@gmail.com.
authors.forename: Mumtaz
authors.initials: M
authors.lastname: Ali
authors.affiliation: Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan. Electronic address: dralatif@uom.edu.pk.
authors.forename: Abdul
authors.initials: A
authors.lastname: Latif
authors.affiliation: Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan.
authors.forename: Khair
authors.initials: K
authors.lastname: Zaman
authors.affiliation: Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Arfan
authors.affiliation: Chemical and Forensic Sciences, University of Bradford, BD7 1DP, UK.
authors.forename: Derek
authors.initials: D
authors.lastname: Maitland
authors.affiliation: Department of Genetics, Hazara University, Mansehra, Pakistan.
authors.forename: Habib
authors.initials: H
authors.lastname: Ahmad
authors.affiliation: Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan.
authors.forename: Manzoor
authors.initials: M
authors.lastname: Ahmad
mesh_terms: D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020902:Hypericum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D014456:Ulcer / Q000188:drug therapy*; D014510:Urease / Q000037:antagonists & inhibitors; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C000594206:3,4-dihydroxy-5-methoxyxanthone; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D044004:Xanthones; C000594203:hypericorin C; C000594204:hypericorin D; D014510:Urease
keywords: 2D-NMR; Anti-ulcer; Hypericorin C; Hypericorin D; Hypericum oblongifolium Wall; Xanthones