title: Risk of coronary artery disease in patients with idiopathic inflammatory myopathies: a systematic review and meta-analysis of observational studies.
abstract: OBJECTIVE
  To investigate the risk of coronary artery disease in patients with idiopathic inflammatory myopathies (IIM).
  
  
  METHODS
  We conducted a systematic review and meta-analysis of observational studies that reported odds ratios, relative risks, hazard ratios, or standardized incidence ratios comparing the risk of coronary artery disease in patients with IIM versus non-IIM participants. We searched published studies indexed in MEDLINE, EMBASE, and the Cochrane database from inception to December 2013 using the terms "coronary artery disease" OR "coronary heart disease" OR "myocardial infarction" OR "atherosclerosis" combined with the terms "dermatomyositis" OR "polymyositis" OR "Idiopathic inflammatory myopathy." Pooled risk ratio and 95% confidence interval were calculated using a random-effect, generic inverse variance method.
  
  
  RESULTS
  Overall, four studies were identified and included for data analysis. The pooled risk ratio of CAD in patients with IIM was 2.24 (95% CI: 1.02-4.92). The statistical heterogeneity of this meta-analysis was high with an I(2) of 97%.
  
  
  CONCLUSIONS
  Our study demonstrated a statistically significant increased risk of CAD among patients with IIM.
authors.affiliation: Department of Medicine, Faculty of medicine Siriraj hospital, Mahidol University, Bangkok 10700, Thailand. Electronic address: P.ungprasert@gmail.com.
authors.forename: Patompong
authors.initials: P
authors.lastname: Ungprasert
authors.affiliation: Department of Cardiology, University of Utah School of Medicine, Salt Lake City, UT.
authors.forename: Promporn
authors.initials: P
authors.lastname: Suksaranjit
authors.affiliation: Department of Internal Medicine, John A. Burns School of medicine, University of Hawaii, Honolulu, HI.
authors.forename: Ittikorn
authors.initials: I
authors.lastname: Spanuchart
authors.affiliation: Department of Internal Medicine, Bassett Medical Center, Columbia University College of Physicians and Surgeons, Cooperstown, NY.
authors.forename: Napat
authors.initials: N
authors.lastname: Leeaphorn
authors.affiliation: Department of Internal Medicine, Bassett Medical Center, Columbia University College of Physicians and Surgeons, Cooperstown, NY.
authors.forename: Nitipong
authors.initials: N
authors.lastname: Permpalung
mesh_terms: D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D015994:Incidence; D009220:Myositis / Q000150:complications* / Q000453:epidemiology; D012306:Risk
keywords: Atherosclerosis; Coronary artery disease; Dermatomyositis; Idiopathic inflammatory myopathies; Meta-analysis; Polymyositis