title: Medicine at the limits of evidence: the fundamental limitation of the randomized clinical trial and the end of equipoise.
authors.affiliation: Department of Pediatrics/MCHE-DPN, Brooke Army Medical Center, Houston, TX, USA.
authors.forename: W
authors.initials: W
authors.lastname: Lefkowitz
authors.affiliation: Department of Pediatrics/MCHE-DPN, Brooke Army Medical Center, Houston, TX, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Jefferson
mesh_terms: D002983:Clinical Competence; D019317:Evidence-Based Medicine / Q000941:ethics; D006801:Humans; D009359:Neonatology / Q000941:ethics; D010102:Oxygen Inhalation Therapy / Q000941:ethics; D016032:Randomized Controlled Trials as Topic / Q000941:ethics / Q000592:standards; D057212:Therapeutic Equipoise