title: A liver-X-receptor ligand, T0901317, attenuates IgE production and airway remodeling in chronic asthma model of mice.
abstract: The liver-X-receptors have shown anti-inflammatory ability in several animal models of respiratory disease. Our purpose is to investigate the effect of LXR ligand in allergen-induced airway remodeling in mice. Ovalbumin-sensitized mice were chronically challenged with aerosolized ovalbumin for 8 weeks. Some mice were administered a LXR agonist, T0901317 (12.5, 25, 50 mg/kg bodyweight) before challenge. Then mice were evaluated for airway inflammation, airway hyperresponsiveness and airway remodeling. T0901317 failed to attenuate the inflammatory cells and Th2 cytokines in bronchoalveolar lavage fluid. But the application of T0901317 reduced the thickness of airway smooth muscle and the collagen deposition. Meanwhile, T0901317 treatment evidently abolished the high level of OVA-specific IgE, TGF-β1 and MMP-9 in lung. So LXRs may attenuate the progressing of airway remodeling, providing a potential treatment of asthma.
authors.affiliation: Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Xiantao
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Mao
authors.affiliation: Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Surong
authors.initials: S
authors.lastname: Fang
authors.affiliation: Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
mesh_terms: D056151:Airway Remodeling / Q000187:drug effects*; D000485:Allergens / Q000494:pharmacology; D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid; D003094:Collagen / Q000378:metabolism; D005260:Female; D006845:Hydrocarbons, Fluorinated / Q000494:pharmacology*; D007073:Immunoglobulin E / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism; D008024:Ligands; D000071518:Liver X Receptors; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D020780:Matrix Metalloproteinase 9; D051379:Mice; D008807:Mice, Inbred BALB C; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism; D057093:Orphan Nuclear Receptors / Q000378:metabolism*; D010047:Ovalbumin / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D005466:Fluorocarbons; D000096926:Benzenesulfonamides
chemical_list: D000485:Allergens; D003094:Collagen; D006845:Hydrocarbons, Fluorinated; D007073:Immunoglobulin E; D008024:Ligands; D000071518:Liver X Receptors; D020780:Matrix Metalloproteinase 9; D057093:Orphan Nuclear Receptors; D010047:Ovalbumin; D013449:Sulfonamides; D053773:Transforming Growth Factor beta1; C423915:T0901317; D005466:Fluorocarbons; D000096926:Benzenesulfonamides