title: Concurrent saturation transfer contrast in in vivo brain by a uniform magnetization transfer MRI.
abstract: The development of chemical exchange saturation transfer (CEST) and magnetization transfer (MT) contrast in MRI has enabled the enhanced detection of metabolites and biomarkers in vivo. In brain MRI, the separation between CEST and MT contrast has been particularly difficult due to overlaps in the frequency responses of the contrast mechanisms. We demonstrate here that MT and CEST contrast can be separated in the brain by the so-called uniform-MT (uMT) technique, thus opening the door to addressing long-standing ambiguities in this field. These methods could be useful for keeping track of important endogenous metabolites and for providing an improved understanding of neurological and neurodegenerative disorders. Examples are shown from white and gray matter regions in healthy volunteers and patients with multiple sclerosis, which demonstrated that the MT effects in the brain were asymmetric and that the uMT method could make them uniform.
authors.affiliation: Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA; Department of Chemistry, New York University, New York, NY 10003, USA.
authors.forename: Jae-Seung
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA.
authors.forename: Ding
authors.initials: D
authors.lastname: Xia
authors.affiliation: Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Ge
authors.affiliation: Department of Chemistry, New York University, New York, NY 10003, USA.
authors.forename: Alexej
authors.initials: A
authors.lastname: Jerschow
authors.affiliation: Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA. Electronic address: Ravinder.Regatte@nyumc.org.
authors.forename: Ravinder R
authors.initials: RR
authors.lastname: Regatte
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009103:Multiple Sclerosis / Q000503:physiopathology
keywords: Chemical exchange saturation transfer; MRI; Magnetization transfer; Multiple sclerosis