title: Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise.
abstract: The senescence-accelerated SAMP8 mouse model displays features of cognitive decline and Alzheimer's disease. With the purpose of identifying potential epigenetic markers involved in aging and neurodegeneration, here we analyzed the expression of 84 mature miRNAs, the expression of histone-acetylation regulatory genes and the global histone acetylation in the hippocampus of 8-month-old SAMP8 mice, using SAMR1 mice as control. We also examined the modulation of these parameters by 8 weeks of voluntary exercise. Twenty-one miRNAs were differentially expressed between sedentary SAMP8 and SAMR1 mice and seven miRNAs were responsive to exercise in both strains. SAMP8 mice showed alterations in genes involved in protein acetylation homeostasis such as Sirt1 and Hdac6 and modulation of Hdac3 and Hdac5 gene expression by exercise. Global histone H3 acetylation levels were reduced in SAMP8 compared with SAMR1 mice and reached control levels in response to exercise. In sum, data presented here provide new candidate epigenetic markers for aging and neurodegeneration and suggest that exercise training may prevent or delay some epigenetic alterations associated with accelerated aging.
authors.affiliation: Unitat de Farmacologia, Facultat de Farmàcia Institut de Biomedicina Universitat de Barcelona (IBUB), Nucli Universitari de Pedralbes Barcelona, Spain ; Department of Brain Ischemia and Neurodegeneration, Institut d'Investigacions Biomèdiques de Barcelona (IIBB)-Consejo Superior de Investigaciones Científicas (CSIC) Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Cosín-Tomás
authors.affiliation: Unitat de Farmacologia, Facultat de Farmàcia Institut de Biomedicina Universitat de Barcelona (IBUB), Nucli Universitari de Pedralbes Barcelona, Spain ; Department of Brain Ischemia and Neurodegeneration, Institut d'Investigacions Biomèdiques de Barcelona (IIBB)-Consejo Superior de Investigaciones Científicas (CSIC) Barcelona, Spain.
authors.forename: María J
authors.initials: MJ
authors.lastname: Alvarez-López
authors.affiliation: Departamento de Psiquiatría y Medicina Legal, Facultad de Medicina, Instituto de Neurociencias, Universitat Autònoma de Barcelona Barcelona, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Sanchez-Roige
authors.affiliation: Departamento de Psiquiatría y Medicina Legal, Facultad de Medicina, Instituto de Neurociencias, Universitat Autònoma de Barcelona Barcelona, Spain.
authors.forename: Jaume F
authors.initials: JF
authors.lastname: Lalanza
authors.affiliation: Unitat de Farmacologia, Facultat de Farmàcia Institut de Biomedicina Universitat de Barcelona (IBUB), Nucli Universitari de Pedralbes Barcelona, Spain.
authors.forename: Sergi
authors.initials: S
authors.lastname: Bayod
authors.affiliation: Department of Brain Ischemia and Neurodegeneration, Institut d'Investigacions Biomèdiques de Barcelona (IIBB)-Consejo Superior de Investigaciones Científicas (CSIC) Barcelona, Spain.
authors.forename: Coral
authors.initials: C
authors.lastname: Sanfeliu
authors.affiliation: Unitat de Farmacologia, Facultat de Farmàcia Institut de Biomedicina Universitat de Barcelona (IBUB), Nucli Universitari de Pedralbes Barcelona, Spain.
authors.forename: Merce
authors.initials: M
authors.lastname: Pallàs
authors.affiliation: Departamento de Psiquiatría y Medicina Legal, Facultad de Medicina, Instituto de Neurociencias, Universitat Autònoma de Barcelona Barcelona, Spain.
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Escorihuela
authors.affiliation: Department of Brain Ischemia and Neurodegeneration, Institut d'Investigacions Biomèdiques de Barcelona (IIBB)-Consejo Superior de Investigaciones Científicas (CSIC) Barcelona, Spain.
authors.forename: Perla
authors.initials: P
authors.lastname: Kaliman
keywords: Alzheimer; SAMP8; aging; exercise; microRNAs