title: Mean platelet volume is related with ischemic stroke in patients with sinus rhythm.
abstract: Stroke is the leading cause of disability worldwide. It is known that atrial fibrillation and left atrial enlargement contribute ischemic stroke, and mean platelet volume (MPV) increases in patients with ischemic stroke and atrial fibrillation. We aimed to determine whether higher MPV is associated with ischemic stroke in patients with sinus rhythm. We evaluated 74 patients in sinus rhythm and with ischemic stroke (Group 1) and 90 age-matched and sex-matched healthy individuals as control group (Group 2). After physical and echocardiographic examination, 24-48 h Holter monitoring and complete blood counts were studied. There were no statistically significant differences in age, sex rates, and comorbidities between groups. Left atrial diameter was higher in Group 1 than Group 2 (P = 0.001), but both were in normal range. MPV was significantly higher in Group 1 (P < 0.001) and was an independent determinant [odds ratio (OR): 1.840; P < 0.001; 95% confidence interval (CI) 1.330-2.545] of ischemic stroke with left atrial (OR: 1.138; P = 0.006; 95% CI 1.037-1.248). In conclusion, higher MPV is associated with acute ischemic stroke in patients with sinus rhythm and without heart failure or left atrial enlargement. MPV and left atrial diameter are independent predictors of ischemic stroke in this patient population.
authors.affiliation: aDepartment of Cardiology, Bucak State Hospital, Burdur bDepartment of Cardiology, Gümüşhane State Hospital, Gümüşhane cDepartment of Internal Medicine, Mersin State Hospital, Mersin dDepartment of Cardiology, Adana Numune Training and Research Hospital, Adana eDepartment of Cardiology, Gazi University Faculty of Medicine, Ankara fDepartment of Cardiology, Kayseri Training and Research Hospital, Kayseri and gDepartment of Neurology, Bucak State Hospital, Burdur Turkey.
authors.forename: Buğra
authors.initials: B
authors.lastname: Özkan
authors.forename: Osman Z
authors.initials: OZ
authors.lastname: Arik
authors.forename: Mehmet Y
authors.initials: MY
authors.lastname: Gözükara
authors.forename: Durmuş Y
authors.initials: DY
authors.lastname: Şahin
authors.forename: Salih
authors.initials: S
authors.lastname: Topal
authors.forename: Onur K
authors.initials: OK
authors.lastname: Uysal
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Tuncay
authors.initials: T
authors.lastname: Epçeliden
authors.forename: Murat
authors.initials: M
authors.lastname: Çayli
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
mesh_terms: D000368:Aged; D001146:Arrhythmia, Sinus / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D001281:Atrial Fibrillation / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000473:pathology*; D006332:Cardiomegaly / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D016022:Case-Control Studies; D005260:Female; D006325:Heart Atria / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D020521:Stroke / Q000097:blood / Q000150:complications / Q000175:diagnosis*
chemical_list: D015415:Biomarkers