title: Magnetic resonance imaging reveals Creutzfeldt-Jakob disease in a patient with apparent dementia with Lewy bodies.
abstract: The differential diagnosis of dementia with Lewy bodies (DLB) and sporadic Creutzfeldt-Jakob disease (CJD) may be challenging. Patients with the original diagnosis of possible CJD may occasionally prove to have a pathological diagnosis of DLB, while other cases may fulfill the diagnostic clinical criteria for DLB but subsequent clinical course, cerebrospinal fluid (CSF) and neuropathology findings necessitate diagnostic revision to CJD. We describe a 79-year old patient recently diagnosed with dementia with Lewy bodies (DLB) on the basis of subacute cognitive decline, visual hallucinations and Parkinsonian features, who presented with increasing agitation. Brain neuroimaging with MRI raised the diagnostic suspicion of CJD and subsequent diagnostic work-up with electroencephalography (EEG) and CSF analysis led to the establishment of CJD diagnosis. The present case highlights the clinical utility of novel diagnostic CJD criteria that also incorporate neuroimaging findings in the diagnostic CJD panel.
authors.affiliation: Second Department of Neurology, University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece; International Clinical Research Center, St. Anne's University Hospital Brno, Czech Republic. Electronic address: tsivgoulisgiorg@yahoo.gr.
authors.forename: Georgios
authors.initials: G
authors.lastname: Tsivgoulis
authors.affiliation: Second Department of Neurology, University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.
authors.forename: Anastasios
authors.initials: A
authors.lastname: Bonakis
authors.affiliation: Second Department of Radiology, University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.
authors.forename: Matilda A
authors.initials: MA
authors.lastname: Papathanasiou
authors.affiliation: Second Department of Neurology, University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Chondrogianni
authors.affiliation: Second Department of Neurology, University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.
authors.forename: Sokratis G
authors.initials: SG
authors.lastname: Papageorgiou
authors.affiliation: Second Department of Neurology, University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Voumvourakis
authors.affiliation: Second Department of Neurology, University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.
authors.forename: Leonidas
authors.initials: L
authors.lastname: Stefanis
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging; D004569:Electroencephalography; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications / Q000175:diagnosis*; D008297:Male
keywords: Creutzfeldt–Jakob disease; Dementia with Lewy bodies; MRI; Neuroimaging