title: Alternative translation initiation in immunity: MAVS learns new tricks.
abstract: Translational control of gene expression contributes to various aspects of immune function [1]. Recent results by Brubaker et al. [2] show how alternative translation initiation produces distinct isoforms of Mitochondrial Antiviral Signaling (MAVS), an adaptor protein associated with RIG-I and MDA5 that possess unique immunomodulatory properties.
authors.affiliation: Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: Pavel
authors.initials: P
authors.lastname: Ivanov
authors.affiliation: Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Anderson
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000276:immunology*; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D014176:Protein Biosynthesis
chemical_list: D048868:Adaptor Proteins, Signal Transducing