title: Oxidative stress in Alzheimer's disease: why did antioxidant therapy fail?
abstract: Alzheimer's disease (AD) is the most common form of dementia in the elderly, with increasing prevalence and no disease-modifying treatment available yet. A remarkable amount of data supports the hypothesis that oxidative stress is an early and important pathogenic operator in AD. However, all clinical studies conducted to date did not prove a clear beneficial effect of antioxidant treatment in AD patients. In the current work, we review the current knowledge about oxidative stress in AD pathogeny and we suggest future paths that are worth to be explored in animal models and clinical studies, in order to get a better approach of oxidative imbalance in this inexorable neurodegenerative disease.
authors.affiliation: KI-Alzheimer's Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 14186 Huddinge, Sweden.
authors.forename: Torbjörn
authors.identifier: 0000-0002-9626-1621
authors.initials: T
authors.lastname: Persson
authors.affiliation: Department of Neurology, Colentina Clinical Hospital (CDPC), School of Medicine, "Carol Davila" University of Medicine and Pharmacy, 19-21 Sos. Stefan cel Mare, District 2, 020125 Bucharest, Romania ; Laboratory of Molecular Medicine and Neuroscience, "Victor Babeş" National Institute of Pathology, 99-101 Splaiul Independenţei, District 5, 050096 Bucharest, Romania.
authors.forename: Bogdan O
authors.identifier: 0000-0003-4826-2598
authors.initials: BO
authors.lastname: Popescu
authors.affiliation: KI-Alzheimer's Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 14186 Huddinge, Sweden.
authors.forename: Angel
authors.initials: A
authors.lastname: Cedazo-Minguez
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D018384:Oxidative Stress; D017211:Treatment Failure
chemical_list: D000975:Antioxidants