title: Acoustic behavior of microbubbles and implications for drug delivery.
abstract: Ultrasound contrast agents are valuable in diagnostic ultrasound imaging, and they increasingly show potential for drug delivery. This review focuses on the acoustic behavior of flexible-coated microbubbles and rigid-coated microcapsules and their contribution to enhanced drug delivery. Phenomena relevant to drug delivery, such as non-spherical oscillations, shear stress, microstreaming, and jetting will be reviewed from both a theoretical and experimental perspective. Further, the two systems for drug delivery, co-administration and the microbubble as drug carrier system, are reviewed in relation to the microbubble behavior. Finally, future prospects are discussed that need to be addressed for ultrasound contrast agents to move from a pre-clinical tool into a clinical setting.
authors.affiliation: Department of Biomedical Engineering, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands. Electronic address: k.kooiman@erasmusmc.nl.
authors.forename: Klazina
authors.initials: K
authors.lastname: Kooiman
authors.affiliation: Department of Biomedical Engineering, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands; Laboratory of Acoustical Wavefield Imaging, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.
authors.forename: Hendrik J
authors.initials: HJ
authors.lastname: Vos
authors.affiliation: Physics of Fluids Group, MIRA Institute of Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands.
authors.forename: Michel
authors.initials: M
authors.lastname: Versluis
authors.affiliation: Department of Biomedical Engineering, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands; Laboratory of Acoustical Wavefield Imaging, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.
authors.forename: Nico
authors.initials: N
authors.lastname: de Jong
mesh_terms: D000162:Acoustics; D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D045423:Microbubbles
keywords: Acoustic cavitation; Acoustic microstreaming; Co-administration; Drug carrier system; Drug release; Drug uptake; Microcapsule; Ultrasound contrast agent