title: Effect of topical tetracycline on seroma formation in the Lichtenstein technique: a prospective randomized study.
abstract: We sought to investigate whether application of topical tetracycline has a limiting effect on seroma formation in patients undergoing hernia repair using a polypropylene mesh. This study was conducted in 96 patients undergoing an elective groin hernia repair. Patients were randomized and divided into 2 groups. After the graft was placed, and before external oblique muscle aponeurosis was closed, 5 mL tetracycline was administered on the graft in the tetracycline group (tetra group, n = 50), and 5 mL isotonic saline was administered in the control group (n = 46) without putting in a drain. Seroma checks via surface ultrasonography were done. Seroma amounts measured on the first day were significantly higher in the tetra group (P = 0.04). There were no significant differences regarding seroma measurements on the seventh day or in the first and second months. Topical tetracycline application has no limiting effect on seroma formation after a groin hernia operation.
authors.affiliation: 1 Department of General Surgery and 2Department of Radiology, Baskent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Turk
authors.forename: Erdal
authors.initials: E
authors.lastname: Karagulle
authors.forename: Gokcen
authors.initials: G
authors.lastname: Coban
authors.forename: Erkan
authors.initials: E
authors.lastname: Yildirim
authors.forename: Gokhan
authors.initials: G
authors.lastname: Moray
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017558:Elective Surgical Procedures / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006552:Hernia, Inguinal / Q000601:surgery*; D059685:Herniorrhaphy / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D049291:Seroma / Q000209:etiology / Q000517:prevention & control*; D016037:Single-Blind Method; D013526:Surgical Mesh; D013752:Tetracycline / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D013752:Tetracycline