title: Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue.
abstract: The quinolinium chloride salt of 8-hydroxyqinolinecarbaldehyde (2-Formyl-8-hydroxy-quinolinium chloride) was prepared as Galipea longiflora alkaloid analogue and its anticancer activity was evaluated both in vitro and in vivo. This chloride salt was found to show certain degree of selectivity between hepatoma cells and normal hepatocytes in vitro. Athymic nude mice Hep3B xenograft model further demonstrated that this 2-Formyl-8-hydroxy-quinolinium chloride could execute strong anti-tumour activity with the identification of extensive necrotic feature from the tumour xenograft and limited adverse toxicological effect.
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, People's Republic of China. Electronic address: kim.hung.lam@polyu.edu.hk.
authors.forename: Kim-Hung
authors.initials: KH
authors.lastname: Lam
authors.affiliation: School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: Kenneth Ka-Ho
authors.initials: KK
authors.lastname: Lee
authors.affiliation: Centre of Biotechnology, Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.affiliation: School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: Stanton Hon-Lung
authors.initials: SH
authors.lastname: Kok
authors.affiliation: School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: Tsz-Wai
authors.initials: TW
authors.lastname: Kok
authors.affiliation: Institute of Creativity, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, People's Republic of China; Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, People's Republic of China.
authors.forename: Albert Sun-Chi
authors.initials: AS
authors.lastname: Chan
authors.affiliation: Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, People's Republic of China.
authors.forename: Zhao-Xiang
authors.initials: ZX
authors.lastname: Bian
authors.affiliation: Institute of Creativity, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, People's Republic of China.
authors.forename: Wai-Yeung
authors.initials: WY
authors.lastname: Wong
authors.affiliation: School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: Raymond Siu-Ming
authors.initials: RS
authors.lastname: Wong
authors.affiliation: School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: Fung-Yi
authors.initials: FY
authors.lastname: Lau
authors.affiliation: School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: See-Wai
authors.initials: SW
authors.lastname: Tong
authors.affiliation: School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: Kit-Wah
authors.initials: KW
authors.lastname: Chan
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, People's Republic of China.
authors.forename: Chor-Hing
authors.initials: CH
authors.lastname: Cheng
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, People's Republic of China; School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China; Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, People's Republic of China. Electronic address: chchui@graduate.hku.hk.
authors.forename: Chung-Hin
authors.initials: CH
authors.lastname: Chui
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, People's Republic of China. Electronic address: bccotang@polyu.edu.hk.
authors.forename: Johnny Cheuk-On
authors.initials: JC
authors.lastname: Tang
mesh_terms: D000470:Alkaloids / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D002712:Chlorides / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D022781:Hepatocytes / Q000187:drug effects; D064593:Heterografts; D066298:In Vitro Techniques; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D009336:Necrosis; D008517:Phytotherapy; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D011806:Quinolinium Compounds / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D027821:Rutaceae / Q000737:chemistry*; D012492:Salts
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D002712:Chlorides; D010936:Plant Extracts; D011806:Quinolinium Compounds; D012492:Salts
keywords: Alkaloid analogues; Anti-tumour; Galipea longiflora