title: Decreased serum zinc is an effect of ageing and not Alzheimer's disease.
abstract: We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.
authors.affiliation: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia. blaine.roberts@florey.edu.au.
authors.forename: Alan
authors.initials: A
authors.lastname: Rembach
authors.forename: Dominic J
authors.initials: DJ
authors.lastname: Hare
authors.forename: James D
authors.initials: JD
authors.lastname: Doecke
authors.forename: Samantha C
authors.initials: SC
authors.lastname: Burnham
authors.forename: Irene
authors.initials: I
authors.lastname: Volitakis
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Fowler
authors.forename: Robert A
authors.initials: RA
authors.lastname: Cherny
authors.forename: Catriona
authors.initials: C
authors.lastname: McLean
authors.forename: Rudolf
authors.initials: R
authors.lastname: Grimm
authors.forename: Ralph
authors.initials: R
authors.lastname: Martins
authors.forename: David
authors.initials: D
authors.lastname: Ames
authors.forename: Colin L
authors.initials: CL
authors.lastname: Masters
authors.forename: Ashley I
authors.initials: AI
authors.lastname: Bush
authors.forename: Blaine R
authors.initials: BR
authors.lastname: Roberts
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000544:Alzheimer Disease / Q000097:blood*; D053327:Apolipoprotein E4 / Q000097:blood / Q000235:genetics; D001315:Australia; D015415:Biomarkers / Q000097:blood; D060825:Cognitive Dysfunction / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008019:Life Style; D008137:Longitudinal Studies; D008297:Male; D015032:Zinc / Q000097:blood*
chemical_list: D053327:Apolipoprotein E4; D015415:Biomarkers; D015032:Zinc