title: [Evaluation of the quality of scientific evidence of pharmaceutical interventions in an emergency department].
abstract: OBJECTIVE
  To assess the quality of Pharmaceutical Interventions of starting a drug treatment based on the available scientific evidence, in an Emergency Department with a Clinical Pharmacist working full-time. To analyze the rate of Pharmaceutical Interventions over chronic or acute treatments and the ATC group of drugs involved.
  
  
  METHODS
  The pharmacotherapy recommendations on Clinical Practice Guidelines (CPG) were classified and for every Pharmaceutical Intervention was assessed the quality of scientific evidence, strength of clinical recommendation, morbidity/mortality reduction, chronic or acute treatment and ATC group of drug involved.
  
  
  RESULTS
  During the study period 2776 Pharmaceutical Interventions were performed of which 47% were starting-drug interventions, being 73% justified with scientific evidence. The 84% of starting-drug interventions were assessed with quality of evidence and strength of recommendation IA, 9% IC and 4% IB and 67% have been shown to reduce the morbidity/mortality according the CPG. 73% of interventions were related with patients' chronic treatment and ATC groups most frequently involved were N group (nervous system) and C group (cardiovascular system). In acute treatment the most frequent were B group and A group (Alimentary tract and metabolism).
  
  
  CONCLUSIONS
  The starting-drug Pharmaceutical Interventions performed by an emergency department clinical pharmacist show a high adherence to CPG for most frequent pathologies, with good quality of evidence and good strength of recommendation as well as an associated morbidity/mortality reduction. Most starting-drug interventions were related to chronic treatment reconciliation, being drugs of N and C ATC group the most frequent involved.
authors.affiliation: Servicio de Farmacia. Hospital Universitario de Gran Canaria Doctor Negrín. Las Palmas de Gran Canaria. España.. mperleon@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Pérez León
authors.affiliation: Servicio de Farmacia. Hospital Universitario de Gran Canaria Doctor Negrín. Las Palmas de Gran Canaria. España..
authors.forename: H
authors.initials: H
authors.lastname: Alonso Ramos
authors.affiliation: Servicio de Farmacia. Hospital Universitario de Gran Canaria Doctor Negrín. Las Palmas de Gran Canaria. España..
authors.forename: S
authors.initials: S
authors.lastname: González Munguía
authors.affiliation: Servicio de Farmacia. Hospital Universitario de Gran Canaria Doctor Negrín. Las Palmas de Gran Canaria. España..
authors.forename: S M
authors.initials: SM
authors.lastname: Marrero Penichet
authors.affiliation: Servicio de Farmacia. Hospital Universitario de Gran Canaria Doctor Negrín. Las Palmas de Gran Canaria. España..
authors.forename: R
authors.initials: R
authors.lastname: Molero Gómez
mesh_terms: D004358:Drug Therapy / Q000592:standards*; D004632:Emergency Medical Services / Q000592:standards*; D004636:Emergency Service, Hospital / Q000458:organization & administration*; D019317:Evidence-Based Medicine / Q000592:standards*; D019983:Guideline Adherence; D017408:Guidelines as Topic; D017052:Hospital Mortality; D006801:Humans; D010607:Pharmacy Service, Hospital / Q000592:standards*; D012189:Retrospective Studies