title: Inferring influenza global transmission networks without complete phylogenetic information.
abstract: Influenza is one of the most severe respiratory infections affecting humans throughout the world, yet the dynamics of its global transmission network are still contentious. Here, I describe a novel combination of phylogenetics, time series, and graph theory to analyze 14.25 years of data stratified in space and in time, focusing on the main target of the human immune response, the hemagglutinin gene. While bypassing the complete phylogenetic inference of huge data sets, the method still extracts information suggesting that waves of genetic or of nucleotide diversity circulate continuously around the globe for subtypes that undergo sustained transmission over several seasons, such as H3N2 and pandemic H1N1/09, while diversity of prepandemic H1N1 viruses had until 2009 a noncontinuous transmission pattern consistent with a source/sink model. Irrespective of the shift in the structure of H1N1 diversity circulation with the emergence of the pandemic H1N1/09 strain, US prevalence peaks during the winter months when genetic diversity is at its lowest. This suggests that a dominant strain is generally responsible for epidemics and that monitoring genetic and/or nucleotide diversity in real time could provide public health agencies with an indirect estimate of prevalence.
authors.affiliation: Department of Biology, Center for Advanced Research in Environmental Genomics, University of Ottawa Ottawa, ON, Canada ; Department of Mathematics and Statistics, University of Ottawa Ottawa, ON, Canada.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Aris-Brosou
keywords: PageRank algorithm; genetic diversity; global dynamics; influenza; prevalence; transmission network