title: Glued versus stapled anastomosis of the colon: an experimental study to determine comparative resistance to intraluminal pressure.
abstract: BACKGROUND
  This study compared the resistance of glued versus stapled anastomosis of the colon to intraluminal pressures at different times during healing.
  
  
  METHODS
  Forty seven female domestic pigs, mean weight of 30.7 kg, were used. Maximum physiological luminal pressures, i.e. the pressure resisted by a catheter inserted into the intestinal lumen via a puncture without it being released and without injury to the surrounding intestinal wall, was performed in 5 control animals. The remaining 42 animals were divided into 3 groups of 14 animals each based on time from anastomosis construction. Each group was divided into 2 subgroups with stapled or glued anastomoses. Intraluminal pressure was measured on the first, third, and fifth day post-surgery.
  
  
  RESULTS
  The maximum pressures resisted by anastomoses were significantly higher than the physiological pressures in all groups. At all time points, stapled anastomoses resisted higher intraluminal pressures than glued ones. However, glued anastomoses resisted pressures significantly higher than physiological pressure. As healing advanced, glued anastomoses neared the resistance to intraluminal pressures of stapled anastomoses.
  
  
  CONCLUSIONS
  Healing with absorbable synthetic glue was as good as with staples. Glued anastomoses resisted pressures that were statistically significantly higher than physiological intraluminal colon pressures but lower than stapled ones.
authors.affiliation: Department of Field Surger, Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic. Electronic address: jiri.paral@seznam.cz.
authors.forename: Jiri
authors.initials: J
authors.lastname: Paral
authors.affiliation: Department of Field Surger, Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Lochman
authors.affiliation: Na Homolce Hospital, Department of Surgery, Prague, Czech Republic.
authors.forename: Slavomir
authors.initials: S
authors.lastname: Blazej
authors.affiliation: Department for Teaching, Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Pavlik
mesh_terms: D000269:Adhesives / Q000627:therapeutic use*; D000818:Animals; D003106:Colon / Q000601:surgery*; D005260:Female; D011312:Pressure; D013537:Sutures; D013552:Swine
chemical_list: D000269:Adhesives
keywords: anastomosis; colon; cyanoacrylate; glubran 2; intraluminal pressure; tissue glue