title: Dense calcification in a GH-secreting pituitary macroadenoma.
abstract: A 30-year-old female presented with a history of secondary amenorrhoea, acromegalic features and progressive visual deterioration. She had elevated serum IGF1 levels and unsuppressed GH levels after an oral glucose tolerance test. Magnetic resonance imaging revealed a heterogeneously enhancing space-occupying lesion with atypical extensive calcification within the sellar and suprasellar areas. Owing to the extent of calcification, the tumour was a surgical challenge. Postoperatively, there was clinical, radiological and biochemical evidence of residual disease, which required treatment with a somatostatin analogue and radiotherapy. Mutational analysis of the aryl hydrocarbon receptor-interacting protein (AIP) gene was negative. This case confirms the relatively rare occurrence of calcification within a pituitary macroadenoma and its associated management problems. The presentation, biochemical, radiological and pathological findings are discussed in the context of the relevant literature.
  
  
  CONCLUSIONS
  Calcification of pituitary tumours is relatively rare.Recognising calcification in pituitary adenomas on preoperative imaging is important in surgical decision-making.Gross total resection can be difficult to achieve in the presence of extensive calcification and dictates further management and follow-up to achieve disease control.
authors.affiliation: Royal Hallamshire Hospital Sheffield UK.
authors.forename: Ramez
authors.initials: R
authors.lastname: Ibrahim
authors.affiliation: University Hospital of Wales Cardiff UK.
authors.forename: Atul
authors.initials: A
authors.lastname: Kalhan
authors.affiliation: Cardiff University Cardiff UK.
authors.forename: Alistair
authors.initials: A
authors.lastname: Lammie
authors.affiliation: Bronglais Hospital Aberystwyth UK.
authors.forename: Christine
authors.initials: C
authors.lastname: Kotonya
authors.affiliation: University Hospital of Wales Cardiff UK.
authors.forename: Ravindra
authors.initials: R
authors.lastname: Nannapanenni
authors.affiliation: Institute of Molecular and Experimental Medicine, Cardiff University Cardiff UK.
authors.forename: Aled
authors.initials: A
authors.lastname: Rees