title: Next generation sequencing: potential and application in drug discovery.
abstract: The world has now entered into a new era of genomics because of the continued advancements in the next generation high throughput sequencing technologies, which includes sequencing by synthesis-fluorescent in situ sequencing (FISSEQ), pyrosequencing, sequencing by ligation using polony amplification, supported oligonucleotide detection (SOLiD), sequencing by hybridization along with sequencing by ligation, and nanopore technology. Great impacts of these methods can be seen for solving the genome related problems of plant and animal kingdom that will open the door of a new era of genomics. This may ultimately overcome the Sanger sequencing that ruled for 30 years. NGS is expected to advance and make the drug discovery process more rapid.
authors.affiliation: Hematological Facility, Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India.
authors.forename: Navneet Kumar
authors.initials: NK
authors.lastname: Yadav
authors.affiliation: Hematological Facility, Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India ; Academy of Scientific and Innovative Research, New Delhi 110 001, India.
authors.forename: Pooja
authors.initials: P
authors.lastname: Shukla
authors.affiliation: Hematological Facility, Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India ; Academy of Scientific and Innovative Research, New Delhi 110 001, India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Omer
authors.affiliation: Jaipur National University, Jaipur, Rajasthan 302017, India.
authors.forename: Shruti
authors.initials: S
authors.lastname: Pareek
authors.forename: A K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: F W
authors.initials: FW
authors.lastname: Bansode
authors.forename: R K
authors.initials: RK
authors.lastname: Singh
mesh_terms: D055808:Drug Discovery / Q000379:methods*; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*