title: Comparative analysis of changes of myocardial angiogenesis and energy metabolism in postinfarction and diabetic damage of rat heart.
abstract: Comparative study of changes in myocardial activity of lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), and capillary density distribution in the experimental models of diabetic and postinfarction damage of rat heart was performed. Data showed that decrease in LDH and SDH activities was observed in both pathologies which can suggest abnormal processes of glycolysis and oxidative phosphorylation in cardiac mitochondria. Activity of LDH and SDH in combined pathologies was comparative with the corresponding values of these parameters in control group. The authors hypothesize that these differences can be caused by specifics of myocardial vascularization. The results of the study showed that an increase in capillary density was found in all groups of rats with pathologies compared with control group. However, no significant differences in the intensity of angiogenesis processes were found between groups with pathologies.
authors.affiliation: FSBI "RI Cardiology" SB RAMS, 111a Kievskaya Street, Tomsk 634012, Russia.
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Afanasiev
authors.affiliation: FSBI "RI Cardiology" SB RAMS, 111a Kievskaya Street, Tomsk 634012, Russia.
authors.forename: Margarita V
authors.initials: MV
authors.lastname: Egorova
authors.affiliation: FSBI "RI Cardiology" SB RAMS, 111a Kievskaya Street, Tomsk 634012, Russia.
authors.forename: Dina S
authors.initials: DS
authors.lastname: Kondratyeva
authors.affiliation: FSBI "RI Cardiology" SB RAMS, 111a Kievskaya Street, Tomsk 634012, Russia.
authors.forename: Roman E
authors.initials: RE
authors.lastname: Batalov
authors.affiliation: FSBI "RI Cardiology" SB RAMS, 111a Kievskaya Street, Tomsk 634012, Russia.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Popov
mesh_terms: D000818:Animals; D002196:Capillaries / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D003331:Coronary Vessels / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D003925:Diabetic Angiopathies / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D058065:Diabetic Cardiomyopathies / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D004734:Energy Metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D018919:Neovascularization, Physiologic; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase
chemical_list: D005230:Fatty Acids, Nonesterified; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase