title: Preparation and evaluation of three mucoadhesive dosage forms using (99m)Tc-Ofloxacin.
abstract: Preparation of three mucoadhesive formulations was optimized and pharmaceutically evaluated. Ofloxacin was radiolabeled with (99m)Tc and radiolabeled complex was characterized by HPLC. (99m)Tc-Ofloxacin was added as a tracer to the formulations namely Oflox C934, Oflox C940 and Oflox HPMC and the formulations were fed orally to rats. Imaging studies were carried out to assess the prolonged gastric retention of the formulations. (99m)Tc-Ofloxacin served as a good tracer for studying the pharmacokinetics of three controlled release mucoadhesive dosage forms by gamma scintigraphy studies.
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India. Electronic address: archanas@barc.gov.in.
authors.forename: Archana
authors.initials: A
authors.lastname: Mukherjee
authors.affiliation: Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela, Odisha, India.
authors.forename: Subhashree
authors.initials: S
authors.lastname: Sahoo
authors.affiliation: Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India.
authors.forename: Haladhar Dev
authors.initials: HD
authors.lastname: Sarma
authors.affiliation: Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela, Odisha, India.
authors.forename: Chandra Kanti
authors.initials: CK
authors.lastname: Chakraborti
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India.
authors.forename: Grace
authors.initials: G
authors.lastname: Samuel
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D003692:Delayed-Action Preparations; D065347:Hypromellose Derivatives / Q000737:chemistry; D007553:Isotope Labeling / Q000379:methods; D008855:Microscopy, Electron, Scanning; D015242:Ofloxacin / Q000008:administration & dosage* / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds / Q000008:administration & dosage* / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000179:Acrylates; D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D065347:Hypromellose Derivatives; C006903:carbopol 940; D015242:Ofloxacin; C453622:carbopol 934P
keywords: (99m)Tc–Ofloxacin; Carbopol 934; Carbopol 940; Hydroxypropyl methyl cellulose (HPMC); Mucoadhesive suspension