title: Endocrine and metabolic mechanisms linking postpartum glucose with early embryonic and foetal development in dairy cows.
abstract: Milk and milk solids production per cow is increasing annually in dairy systems. Peak milk production is in early lactation when the uterus and ovary are recovering from the previous pregnancy. The competing processes of milk production and restoration of reproductive function can be at odds, particularly if unique homeorhetic mechanisms that typify early lactation become imbalanced and cows experience metabolic disease. Homeorhesis leads to an increase in the synthesis of glucose that is irreversibly lost to milk lactose. Irreversible loss of glucose during lactation can invoke an endocrine and metabolic state that impinges upon postpartum uterine health, oestrous cyclicity and subsequent establishment of pregnancy. The first 30 days postpartum may be most critical in terms of the impact that metabolites and metabolic hormones have on reproduction. Depressed immune function caused in part by the postpartum metabolic profile leads to a failure in uterine involution and uterine disease. Oestrous cyclicity (interval to first ovulation and subsequent periodicity) is affected by the same hormones and metabolites that control postpartum immune function. Slower growth of the embryo or foetus perhaps explained by the unique metabolic profile during lactation may predispose cows to pregnancy loss. Understanding homeorhetic mechanisms that involve glucose and collectively affect postpartum uterine health, oestrous cyclicity and the establishment of pregnancy should lead to methods to improve postpartum fertility in dairy cows.
authors.affiliation: 1Division of Animal Sciences,University of Missouri,Columbia,MO,USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Lucy
authors.affiliation: 2Animal & Grasslands Research and Innovation Centre,Teagasc Moorepark,Fermoy Co Cork,Ireland.
authors.forename: S T
authors.initials: ST
authors.lastname: Butler
authors.affiliation: 1Division of Animal Sciences,University of Missouri,Columbia,MO,USA.
authors.forename: H A
authors.initials: HA
authors.lastname: Garverick
mesh_terms: D000818:Animals; D002417:Cattle / Q000196:embryology / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology*; D004703:Endocrine System / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D007774:Lactation / Q000502:physiology; D049590:Postpartum Period; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*
chemical_list: D005947:Glucose