title: New barbiturates and thiobarbiturates as potential enzyme inhibitors.
abstract: A series of 27 new barbiturates and thiobarbiturates have been synthesized by a convenient multi-component reaction in overall excellent yields (87-96%). All the synthesized compounds were characterized by 1H, 13C NMR, EIMS and elemental analysis (C, H, N and S). Furthermore, all compounds were screened for in vitro antioxidant (DPPH radical scavenging), lipoxygenase, chymotrypsin, α-glucosidase and anti-urease activities. Out of the series, 23 in DPPH, 14 in lipoxygenase, 2 in chymotrypsin have shown appreciable IC50 values.
authors.affiliation: Institute of Chemical Sciences, Bahauddin Zakariya University , Multan , Pakistan .
authors.forename: Ashfaq M
authors.initials: AM
authors.lastname: Qureshi
authors.forename: Saira
authors.initials: S
authors.lastname: Mumtaz
authors.forename: Abdul
authors.initials: A
authors.lastname: Rauf
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
authors.forename: Rumana
authors.initials: R
authors.lastname: Nasar
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D001463:Barbiturates / Q000138:chemical synthesis* / Q000737:chemistry; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors; D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000737:chemistry; D057075:Enzyme Assays; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D008084:Lipoxygenase / Q000737:chemistry; D010851:Picrates / Q000037:antagonists & inhibitors; D013858:Thiobarbiturates / Q000138:chemical synthesis* / Q000737:chemistry; D014510:Urease / Q000037:antagonists & inhibitors / Q000737:chemistry; D000520:alpha-Glucosidases / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001463:Barbiturates; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D010851:Picrates; D013858:Thiobarbiturates; C004931:1,1-diphenyl-2-picrylhydrazyl; D008084:Lipoxygenase; D000520:alpha-Glucosidases; D002918:Chymotrypsin; D014510:Urease
keywords: antioxidant (DPPH radical scavenging); barbituric acid; chymotrypsin; lipoxygenase; thiobarbituric acid; thiosemicarbazone; α-Glucosidase and anti-urease