title: Comparative evaluation of antiproliferative effects of Brazilian green propolis, its main source Baccharis dracunculifolia, and their major constituents artepillin C and baccharin.
abstract: This study evaluated the antiproliferative activity of the Brazilian green propolis and Baccharis dracunculifolia extracts and their major compounds artepillin C and baccharin in different tumor cell lines. The lowest IC50 values observed for Brazilian green propolis and B. dracunculifolia extracts were 41.0 ± 4.5 µg/mL for U343 and 44.9 ± 7.1 µg/mL for HepG2, respectively. Regarding artepillin C and baccharin, the lowest IC50 values were 20.1 ± 2.9 for U343 and 13.0 ± 1.5 µg/mL for B16F10, respectively. For the association of artepillin C plus baccharin, the lowest IC50 result was 35.2 ± 0.5 µg/mL for B16F10. Artepillin C and baccharin were more cytotoxic than both Brazilian green propolis and B. dracunculifolia extracts. No additive or synergistic effect was observed for the association of artepillin C plus baccharin.
authors.affiliation: Universidade de Franca, Franca, São Paulo, Brazil.
authors.forename: Pollyanna Francielli
authors.initials: PF
authors.lastname: de Oliveira
authors.affiliation: Universidade de Franca, Franca, São Paulo, Brazil.
authors.forename: Ildercílio Mota
authors.initials: IM
authors.lastname: de Souza Lima
authors.affiliation: Universidade de Franca, Franca, São Paulo, Brazil.
authors.forename: Carla Carolina
authors.initials: CC
authors.lastname: Munari
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
authors.forename: Jairo Kenupp
authors.initials: JK
authors.lastname: Bastos
authors.affiliation: Faculdade de Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.
authors.forename: Ademar Alves
authors.initials: AA
authors.lastname: da Silva Filho
authors.affiliation: Universidade de Franca, Franca, São Paulo, Brazil.
authors.forename: Denise Crispim
authors.initials: DC
authors.lastname: Tavares
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use; D056705:Apitherapy; D031175:Baccharis / Q000737:chemistry*; D001938:Brazil; D019073:HT29 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D009369:Neoplasms / Q000188:drug therapy*; D010666:Phenylpropionates / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011429:Propolis / Q000494:pharmacology / Q000627:therapeutic use*; D014255:Trichothecenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D010666:Phenylpropionates; D010936:Plant Extracts; D014255:Trichothecenes; C102259:artepillin C; D011429:Propolis; C012764:baccharin