title: Critical parameters involved in producing microspheres by prilling of molten lipids: from theoretical prediction of particle size to practice.
abstract: The aim of this work was to identify the key parameters which influence the running of the prilling process with lipid material from the initial melting to the formation of solid microspheres. The microsphere size would essentially result from break-up at the Rayleigh-Weber's wavelength which mostly depends on the liquid properties (mass density, surface tension and dynamic viscosity). After molten liquid extrusion through the nozzle, the cooling rate is very fast and the instantaneous temperature of the liquid jet decreases rapidly of 0.2-0.3 °C during the duration of the droplet formation (1-2 ms). This leads to no significant modification of the physical characteristics of the lipids and only a very slight change in the dynamic viscosity. Consequently, no significant effect on the optimal wavelength λ(W) and on droplet formation can occur. However, coalescence of liquid droplets has been observed during their fall, probably caused by turbulence into the air column, leading to a minor population of larger microspheres.
authors.affiliation: Institut Galien Paris-Sud, Châtenay-Malabry, France; Sanofi, Carbon Blanc Cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Séquier
authors.affiliation: Institut Galien Paris-Sud, Châtenay-Malabry, France. Electronic address: vincent.faivre@u-psud.fr.
authors.forename: V
authors.initials: V
authors.lastname: Faivre
authors.affiliation: Sanofi, Carbon Blanc Cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Daste
authors.affiliation: Sanofi, Carbon Blanc Cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Renouard
authors.affiliation: Institut Galien Paris-Sud, Châtenay-Malabry, France.
authors.forename: S
authors.initials: S
authors.lastname: Lesieur
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D008055:Lipids / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D013499:Surface Properties; D013500:Surface Tension; D013696:Temperature; D014783:Viscosity
chemical_list: D008055:Lipids
keywords: Jet break-up; Lipid; Microsphere; Orifice coefficient; Prilling; Rayleigh–Weber; Viscosity