title: Direct N-acylation of azoles via a metal-free catalyzed oxidative cross-coupling strategy.
abstract: The KI-catalyzed N-acylation of azoles via direct oxidative coupling of C-H and N-H bonds has been developed. It could be smoothly scaled up to gram synthesis of acyl azoles. The reaction occurred by the coupling of acyl radicals and azoles to form the acyl azole radical anion, followed by its further oxidation.
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China. fuweili@licp.cas.cn.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhao
authors.forename: Pan
authors.initials: P
authors.lastname: Li
authors.forename: Chungu
authors.initials: C
authors.lastname: Xia
authors.forename: Fuwei
authors.initials: F
authors.lastname: Li
mesh_terms: D000215:Acylation / Q000502:physiology; D001393:Azoles / Q000737:chemistry* / Q000378:metabolism*; D002384:Catalysis; D008670:Metals; D010084:Oxidation-Reduction; D058451:Oxidative Coupling
chemical_list: D001393:Azoles; D008670:Metals