title: [Testicular germ cell tumours and early exposures to pesticides: The TESTEPERA pilot study].
abstract: Testicular germ cell tumors (TGCT) represent the most frequent cancer in men aged between 15 and 45 years. Current hypotheses are focusing on environmental exposures occurring during prenatal periods. However, very few studies have explored intra-uterine environmental exposure related to TGCT. TESTEPERA is a pilot case-control study aiming to determine the effectiveness of different recruitment approaches in the French context and to verify our ability to collect relevant data on their prenatal periods. Between 2011 and 2012, 150 male subjects were contacted in the Rhône-Alpes region (58 cases from a cancer center and 92 controls from a regional maternity). Participation rate varied from 33% for cases diagnosed in 2008 vs 68% for cases diagnosed in 2010. Participation rate of controls varied depending on modalities of contact (13% for face-to-face recruitment; 0% for contact by phone only; 50% for face-to-face contact with phone reminder). Data collection allowed precise job identification and geolocation of subjects' addresses. Precision of geolocation was dependent upon the level of urbanization (p < 0.001) but not on the time period (p = 0.52). Our results support the feasibility of a case-control study focusing on the relation between TGCT and environmental pesticide exposures during early and later life.
authors.affiliation: Centre Léon-Bérard, Unité Cancer et Environnement, 28, rue Laennec, 69373 Lyon cedex, France, Centre international de recherche sur le cancer, Section Environnement et Rayonnements, 150, cours Albert-Thomas, 69372 Lyon cedex, France, Université Claude-Bernard Lyon 1, 43, boulevard du 11-Novembre-1918, 69622 Villeurbanne cedex, France.
authors.forename: Rémi
authors.initials: R
authors.lastname: Béranger
authors.affiliation: Centre Léon-Bérard, Unité Cancer et Environnement, 28, rue Laennec, 69373 Lyon cedex, France.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Blain
authors.affiliation: Centre Léon-Bérard, Unité Cancer et Environnement, 28, rue Laennec, 69373 Lyon cedex, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Baudinet
authors.affiliation: Centre Léon-Bérard, Unité Cancer et Environnement, 28, rue Laennec, 69373 Lyon cedex, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Faure
authors.affiliation: Centre Léon-Bérard, Département d'oncologie médicale, 28, rue Laennec, 69373 Lyon cedex, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Fléchon
authors.affiliation: Centre Léon-Bérard, Département d'oncologie médicale, 28, rue Laennec, 69373 Lyon cedex, France.
authors.forename: Helen
authors.initials: H
authors.lastname: Boyle
authors.affiliation: Université Jean-Moulin Lyon 3, EA 4129 « Santé, Individu, Société », 7, rue Chevreul, 69007 Lyon, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Chasles
authors.affiliation: Université Claude-Bernard Lyon 1, UMRESTTE UMR T 9405, 43, boulevard du 11-Novembre-1918, 69622 Villeurbanne cedex, France.
authors.forename: Barbara
authors.initials: B
authors.lastname: Charbotel
authors.affiliation: Centre international de recherche sur le cancer, Section Environnement et Rayonnements, 150, cours Albert-Thomas, 69372 Lyon cedex, France.
authors.forename: Joachim
authors.initials: J
authors.lastname: Schüz
authors.affiliation: Centre Léon-Bérard, Unité Cancer et Environnement, 28, rue Laennec, 69373 Lyon cedex, France, Université Claude-Bernard Lyon 1, 43, boulevard du 11-Novembre-1918, 69622 Villeurbanne cedex, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Fervers
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004781:Environmental Exposure; D005240:Feasibility Studies; D005260:Female; D005602:France; D057092:Geographic Atrophy; D006801:Humans; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D009373:Neoplasms, Germ Cell and Embryonal / Q000139:chemically induced*; D018579:Patient Selection; D010575:Pesticides / Q000633:toxicity*; D010865:Pilot Projects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D012307:Risk Factors; D013736:Testicular Neoplasms / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D010575:Pesticides
keywords: environmental exposures; feasibility study; geographic information systems; pesticides; testicular germ cell cancer