title: The complement system: history, pathways, cascade and inhibitors.
abstract: Since its discovery in the 19th century, the complement system has developed into a clinically significant entity. The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. This article charts the historical progress of our understanding of the complement system and provides a synopsis on the activation pathways and its inherent regulators.
authors.forename: P N
authors.initials: PN
authors.lastname: Nesargikar
authors.forename: B
authors.initials: B
authors.lastname: Spiller
authors.forename: R
authors.initials: R
authors.lastname: Chavez
keywords: complement activation; complement cascade; complement history; complement inhibitors; complement system