title: Factor analysis of risk variables associated with iron status in patients with coronary artery disease.
abstract: OBJECTIVE
  Epidemiological evidence concerning the role of iron, a lipid peroxidation catalyst, in atherosclerosis and coronary artery disease (CAD) is inconsistent.
  
  
  METHODS
  Exploratory factor analysis was used to examine the potential clustering of variables known to be associated with CAD using data from 188 patients with angiographically-approved disease. The resulting factors were then tested for their association with serum ferritin and soluble transferrin receptor (sTfR) as indicators of body iron status.
  
  
  RESULTS
  Factor analysis resulted in a reduction of a variable number from the original 15 to 5 composite clusters. These factors were interpreted as (1) "proatherogenic factor" with positive loadings of TC, LDL-C, apoB and TG; (2) "inflammatory factor" with positive loadings of hsCRP, fibrinogen and MDA; (3) "antiatherogenic factor" with positive loadings of HDL-C and apoA-I; (4) "obesity factor" with positive loadings of weight and waist; and (5) "antioxidative status factor" with positive loadings of SOD and age and negative loading of superoxide anion. "Inflammatory", "obesity" and "antiatherogenic" factors predicted high ferritin values and the "proatherogenic factor" predicted high sTfR values. We compared the ability of the "proatherogenic factor" with that of a multivariable logistic model that included the "proatherogenic factor" and sTfR values in predicting significant stenosis in patients. The area under the ROC curve was 0.692 vs. 0.821, respectively.
  
  
  CONCLUSIONS
  "Inflammatory", "obesity", "antiatherogenic" and "proatherogenic" factors were associated with increased parameters of body iron status. The measurement of sTfR improves the prediction of CAD based on clustered cardiovascular risk factors.
authors.affiliation: Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. Electronic address: vkalima@pharmacy.bg.ac.rs.
authors.forename: Vesna
authors.initials: V
authors.lastname: Spasojevic-Kalimanovska
authors.affiliation: Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
authors.forename: Natasa
authors.initials: N
authors.lastname: Bogavac-Stanojevic
authors.affiliation: Faculty of Medicine, University of Belgrade, Clinical Center of Serbia, Belgrade, Serbia.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Kalimanovska-Ostric
authors.affiliation: Clinical Chemistry Laboratory, Clinical Center "Bezanijska Kosa", Belgrade, Serbia.
authors.forename: Lidija
authors.initials: L
authors.lastname: Memon
authors.affiliation: Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
authors.forename: Slavica
authors.initials: S
authors.lastname: Spasic
authors.affiliation: Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Kotur-Stevuljevic
authors.affiliation: Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
authors.forename: Zorana
authors.initials: Z
authors.lastname: Jelic-Ivanovic
mesh_terms: D003324:Coronary Artery Disease / Q000378:metabolism*; D005163:Factor Analysis, Statistical; D005260:Female; D005293:Ferritins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D011990:Receptors, Transferrin / Q000378:metabolism; D012307:Risk Factors
chemical_list: D011990:Receptors, Transferrin; D005293:Ferritins; D007501:Iron
keywords: Coronary artery disease; Factor analysis; Iron status parameters; Risk factors