title: Using SV119-gold nanocage conjugates to eradicate cancer stem cells through a combination of photothermal and chemo therapies.
abstract: Cancer stem cells (CSCs) are believed to be responsible for the long-term growth of a tumor, as well as its metastasis and recurrence after conventional therapies. Here, it is demonstrated that the sigma-2 receptor is overexpressed on the surface of breast CSCs, and thus could serve as a biomarker for the purpose of targeting. Breast CSCs are targeted with Au nanocages (AuNCs) by functionalizing their surfaces with SV119, a synthetic small molecule capable of binding to the sigma-2 receptor with high specificity. The interiors of the AuNCs could also be loaded with an anticancer drug to be selectively delivered to breast CSCs and released in a controllable fashion. The results demonstrate that the SV119-AuNC conjugate can serve as a new platform to carry out photothermal and chemo therapies simultaneously, eradicating breast CSCs more effectively through a synergetic effect.
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.
authors.forename: Tianmeng
authors.initials: T
authors.lastname: Sun
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Yucai
authors.initials: Y
authors.lastname: Wang
authors.forename: Jinbin
authors.initials: J
authors.lastname: Xu
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Suwanna
authors.initials: S
authors.lastname: Vangveravong
authors.forename: Robert H
authors.initials: RH
authors.lastname: Mach
authors.forename: Younan
authors.initials: Y
authors.lastname: Xia
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D053961:Azabicyclo Compounds / Q000737:chemistry*; D001943:Breast Neoplasms / Q000188:drug therapy; D002219:Carbamates / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry; D005260:Female; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007834:Lasers; D049329:Nanostructures / Q000737:chemistry*; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D010789:Phototherapy; D011485:Protein Binding; D017480:Receptors, sigma / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D053961:Azabicyclo Compounds; D002219:Carbamates; D004337:Drug Carriers; D017480:Receptors, sigma; C579249:SV119; C106107:sigma-2 receptor; D006046:Gold; D004317:Doxorubicin
keywords: SV119; cancer stem cells; gold nanocages; sigma-2 receptor; synergetic effect