title: Deep brain stimulation of the subthalamic nucleus improves pain in Parkinson's disease.
abstract: BACKGROUND
  In Parkinson's disease (PD), chronic pain is a common symptom which markedly affects the quality of life. Some physiological arguments proposed that Deep Brain Stimulation of the Subthalamic Nucleus (STN-DBS) could improve pain in PD.
  
  
  METHODS
  We investigated in 58 PD patients the effect of STN-DBS on pain using the short McGill Pain Questionnaire and other pain parameters such as the Bodily discomfort subscore of the Parkinson's disease Questionnaire 39 and the Unified Parkinson's Disease Rating Scale section II (UPDRS II) item 17.
  
  
  RESULTS
  All pain scores were significantly improved 12 months after STN-DBS. This improvement was not correlated with motor improvement, depression scores or L-Dopa reduction.
  
  
  CONCLUSIONS
  STN-DBS induced a substantial beneficial effect on pain in PD, independently of its motor effects and mood status of patients.
authors.affiliation: INSERM, UMR 825, Toulouse, France; Université de Toulouse, UPS, UMR 825, Toulouse, France. Electronic address: jean.pellaprat@inserm.fr.
authors.forename: Jean
authors.initials: J
authors.lastname: Pellaprat
authors.affiliation: Centre Hospitalier Universitaire de Toulouse, Service de Neurologie, Toulouse, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Ory-Magne
authors.affiliation: Centre Hospitalier Universitaire de Toulouse, Service de Neurologie, Toulouse, France.
authors.forename: Cindy
authors.initials: C
authors.lastname: Canivet
authors.affiliation: INSERM, UMR 825, Toulouse, France; Université de Toulouse, UPS, UMR 825, Toulouse, France; Centre Hospitalier Universitaire de Toulouse, Service de Neurologie, Toulouse, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Simonetta-Moreau
authors.affiliation: INSERM, UMR 825, Toulouse, France; Université de Toulouse, UPS, UMR 825, Toulouse, France; Centre Hospitalier Universitaire de Toulouse, Service de Médecine Nucléaire, Toulouse, France.
authors.forename: Jean-Albert
authors.initials: JA
authors.lastname: Lotterie
authors.affiliation: Centre Hospitalier Universitaire de Toulouse, Service de Neurologie, Toulouse, France.
authors.forename: Fatai
authors.initials: F
authors.lastname: Radji
authors.affiliation: INSERM, UMR 825, Toulouse, France; Université de Toulouse, UPS, UMR 825, Toulouse, France; Centre Hospitalier Universitaire de Toulouse, Service de Psychiatrie, Toulouse, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Arbus
authors.affiliation: INSERM, UMR 825, Toulouse, France; Université de Toulouse, UPS, UMR 825, Toulouse, France; Centre Hospitalier Universitaire de Toulouse, Service de Neurologie, Toulouse, France.
authors.forename: Angélique
authors.initials: A
authors.lastname: Gerdelat
authors.affiliation: Centre Hospitalier Universitaire de Toulouse, Service de Neurochirurgie, Toulouse, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Chaynes
authors.affiliation: INSERM, UMR 825, Toulouse, France; Université de Toulouse, UPS, UMR 825, Toulouse, France; Centre Hospitalier Universitaire de Toulouse, Service de Neurologie, Toulouse, France; Service de Pharmacologie Clinique, Faculté de Médecine, Toulouse, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Brefel-Courbon
mesh_terms: D000368:Aged; D059350:Chronic Pain / Q000209:etiology* / Q000628:therapy*; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010300:Parkinson Disease / Q000150:complications* / Q000628:therapy; D012189:Retrospective Studies; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D020531:Subthalamic Nucleus / Q000502:physiology*; D011795:Surveys and Questionnaires
keywords: Pain; Parkinson's disease; Subthalamic deep brain stimulation (STN-DBS)