title: Combined heterogeneous metal/chiral amine: multiple relay catalysis for versatile eco-friendly synthesis.
abstract: Herein is described a versatile and broad synergistic strategy for expansion of chemical space and the synthesis of valuable molecules (e.g. carbocycles and heterocycles), with up to three quaternary stereocenters, in a highly enantioselective fashion from simple alcohols (31 examples, 95:5 to >99.5:0.5 e.r.) using integrated heterogeneous metal/chiral amine multiple relay catalysis and air/O₂ as the terminal oxidant. A novel highly 1,4-selective heterogeneous metal/amine co-catalyzed hydrogenation of enals was also added to the relay catalysis sequences.
authors.forename: Luca
authors.initials: L
authors.lastname: Deiana
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Carlos
authors.initials: C
authors.lastname: Palo-Nieto
authors.forename: Samson
authors.initials: S
authors.lastname: Afewerki
authors.forename: Celia A
authors.initials: CA
authors.lastname: Incerti-Pradillos
authors.forename: Oscar
authors.initials: O
authors.lastname: Verho
authors.forename: Cheuk-Wai
authors.initials: CW
authors.lastname: Tai
authors.forename: Eric V
authors.initials: EV
authors.lastname: Johnston
authors.forename: Armando
authors.initials: A
authors.lastname: Córdova