title: Non-alcoholic fatty liver disease and risk of in-stent restenosis after bare metal stenting in native coronary arteries.
abstract: In-stent restenosis (ISR) remains the most common complication of percutaneous coronary intervention. Due to shared risk factors, it is postulated that non-alcoholic fatty liver disease (NAFLD) patients have an increased risk of ISR. This study aimed to determine the association between NAFLD and ISR in patients after bare metal stenting. This study included a cohort of 210 consecutive patients (150 men and 60 women) undergoing follow-up angiography. The primary end-point was angiographic ISR. Multivariate logistic regression analysis was used to identify independent risk factors for ISR. The cumulative ISR rate during follow-up was analyzed by Kaplan-Meier method. Subgroup analyses were also done for different gender. The ISR rate was 29.5%. Patients with NAFLD had a significantly higher prevalence of ISR than patients without NAFLD (43.3 vs. 16.0%, P < 0.001). In logistic regression analysis, NAFLD was associated with increased ISR, independent of low-density lipoprotein cholesterol, body mass index (adjusted odds ratio: 2.688, 95% confidence intervals: 1.285-5.537, P < 0.001). Male NAFLD patients had a higher prevalence of ISR than patients without NAFLD (48.4 vs. 15.3%, P < 0.001), while the prevalence of ISR in female patients with and without NAFLD were comparable (7.7 vs. 17.0%, P = 0.404). Kaplan-Meier analysis showed a significant association between NAFLD and ISR in all patients (log-rank P = 0.008) and in male subgroup (log-rank P = 0.033), but not in female subgroup (log-rank P = 0.313). This preliminary study suggests that NAFLD could independently associate with a high prevalence of ISR, especially in male patients.
authors.affiliation: Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, No. 2 Fuxue lane, Wenzhou, 325000, China.
authors.forename: Ke-Qing
authors.initials: KQ
authors.lastname: Shi
authors.forename: Fa-Ling
authors.initials: FL
authors.lastname: Wu
authors.forename: Wen-Yue
authors.initials: WY
authors.lastname: Liu
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Zhao
authors.forename: Chang-Xi
authors.initials: CX
authors.lastname: Chen
authors.forename: Yao-Yao
authors.initials: YY
authors.lastname: Xie
authors.forename: Sheng-Jie
authors.initials: SJ
authors.lastname: Wu
authors.forename: Xian-Feng
authors.initials: XF
authors.lastname: Lin
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Chen
authors.forename: Danny Ka-Ho
authors.initials: DK
authors.lastname: Wong
authors.forename: Man-Fung
authors.initials: MF
authors.lastname: Yuen
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Zheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography / Q000009:adverse effects* / Q000295:instrumentation; D023903:Coronary Restenosis / Q000097:blood / Q000209:etiology* / Q000473:pathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000150:complications* / Q000473:pathology; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects* / Q000295:instrumentation; D012307:Risk Factors; D012737:Sex Factors; D013193:Stainless Steel; D015607:Stents
chemical_list: D008078:Cholesterol, LDL; D013193:Stainless Steel