title: [Vascular normalization and cancer immunotherapy].
abstract: Immunotherapies, as a promising anticancer therapy stratrgy, has been paid more and more attentions. However, the abnormal tumor vasculature creates a hypoxic microenvironment that make immune cells toward immune suppression. The immunosuppressive microenvironment seems to impede the development of immunotherapies. Hence, normalization tumor vascular by anti-angiogenesis properly could improve the immunosuppressive miroenvironment. Consequently, the efficacy of the immunotherapies was enhanced. Here, we discuss the effects of vascular normalizing on tumor immunity and propose a potentially strategy to re-engineer the tumor-immune microenvironment and improve cancer immunotherapy.
authors.affiliation: Graduate School, Nanfang Medical University, 510515 Guangzhou, China;Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China.
authors.forename: Junli
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yuan
authors.affiliation: Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Song
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage; D000818:Animals; D006801:Humans; D007167:Immunotherapy; D008168:Lung / Q000098:blood supply* / Q000187:drug effects / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D009389:Neovascularization, Pathologic; D059016:Tumor Microenvironment
chemical_list: D020533:Angiogenesis Inhibitors