title: Gold-catalyzed enantioselective ring-expanding cycloisomerization of cyclopropylidene bearing 1,5-enynes.
abstract: An enantioselective ring-expanding cycloisomerization of 1,5-enynes bearing a cyclopropylidene moiety has been developed. This methodology provides a new approach to bicyclo[4.2.0]octanes, a structural motif present in many biologically active natural products.
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States.
authors.forename: Hongchao
authors.initials: H
authors.lastname: Zheng
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Felix
authors.forename: Michel R
authors.initials: MR
authors.lastname: Gagné
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D003521:Cyclopropanes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D009795:Octanes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001688:Biological Products; D001643:Bridged Bicyclo Compounds; D003521:Cyclopropanes; D009795:Octanes; D006046:Gold