title: Transient nephrogenic diabetes insipidus caused by fetal exposure to haloperidol.
abstract: Haloperidol is commonly used in the treatment of psychiatric disorders. Data from animal experiments indicate haloperidol is not teratogenic, but is embryotoxic in high doses. For the first time, we report a neonate with transient nephrogenic diabetes insipidus (DI) caused by fetal exposure to haloperidol. The magnitude of risk associated with the use of haloperidol during pregnancy appears to be small, but nephrogenic DI secondary to haloperidol is a serious condition with the risk of hypernatremic dehydration. Haloperidol can have adverse effects on the fetus and newborn infant, that's why one should prevent the use of haloperidol during pregnancy and lactation.
authors.affiliation: Department of Neonatology, Diyarbakir Children Hospital , Diyarbakir , Turkey.
authors.forename: Melek
authors.initials: M
authors.lastname: Akar
authors.forename: Çiğdem Seher
authors.initials: ÇS
authors.lastname: Kasapkara
authors.forename: Mehmet Nuri
authors.initials: MN
authors.lastname: Özbek
authors.forename: Heybet
authors.initials: H
authors.lastname: Tüzün
authors.forename: Bedri
authors.initials: B
authors.lastname: Aldudak
authors.forename: Berat
authors.initials: B
authors.lastname: Kanar
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D018500:Diabetes Insipidus, Nephrogenic / Q000139:chemically induced*; D005260:Female; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D014150:Antipsychotic Agents; D006220:Haloperidol
keywords: Haloperidol; neonate; nephrogenic diabetes insipidus