title: Accelerated stability assay (ASA) for colloidal systems.
abstract: Assessment of the stability of colloidal systems, in particular lyotropic liquid crystalline dispersions, such as cubosomes and hexosomes, is typically performed qualitatively or with limited throughput on specialized instruments. Here, an accelerated stability assay for colloidal particles has been developed in 384-well plates with standard laboratory equipment. These protocols enable quantitative assessments of colloidal stability. To demonstrate the applicability of the assay, several steric stabilizers for cubic phase nanostructured particles (cubosomes) have been compared to the current "gold standard" Pluronic F127.
authors.affiliation: CSIRO Materials Science and Engineering , Private Bag 10, Clayton, Victoria 3169, Australia.
authors.forename: Josephine Y T
authors.initials: JY
authors.lastname: Chong
authors.forename: Xavier
authors.initials: X
authors.lastname: Mulet
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Boyd
authors.forename: Calum J
authors.initials: CJ
authors.lastname: Drummond
mesh_terms: D003102:Colloids / Q000737:chemistry*; D050866:Liquid Crystals / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry*
chemical_list: D003102:Colloids; D020442:Poloxamer
keywords: accelerated stability assay; colloidal stability; cubosome; lyotropic liquid crystalline nanoparticle; steric stabilization