title: Pharmacological characterization of standard analgesics on oxaliplatin-induced acute cold hypersensitivity in mice.
abstract: Oxaliplatin, a platinum-based chemotherapeutic agent, causes an acute peripheral neuropathy triggered by cold in almost all patients during or within hours after its infusion. We recently reported that a single administration of oxaliplatin induced cold hypersensitivity 2 h after the administration in mice. In this study, we examined whether standard analgesics relieve the oxaliplatin-induced acute cold hypersensitivity. Gabapentin, tramadol, mexiletine, and calcium gluconate significantly inhibited and morphine and milnacipran decreased the acute cold hypersensitivity, while diclofenac and amitriptyline had no effects. These results suggest that gabapentin, tramadol, mexiletine, and calcium gluconate are effective against oxaliplatin-induced acute peripheral neuropathy.
authors.affiliation: Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhao
authors.forename: Saki
authors.initials: S
authors.lastname: Nakamura
authors.forename: Takahito
authors.initials: T
authors.lastname: Miyake
authors.forename: Kanako
authors.initials: K
authors.lastname: So
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shirakawa
authors.forename: Shogo
authors.initials: S
authors.lastname: Tokuyama
authors.forename: Minoru
authors.initials: M
authors.lastname: Narita
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Shuji
authors.initials: S
authors.lastname: Kaneko
mesh_terms: D000208:Acute Disease; D000588:Amines / Q000627:therapeutic use; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002125:Calcium Gluconate / Q000627:therapeutic use; D056587:Cryopyrin-Associated Periodic Syndromes / Q000139:chemically induced* / Q000188:drug therapy*; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D003521:Cyclopropanes / Q000627:therapeutic use; D000077206:Gabapentin; D008297:Male; D008801:Mexiletine / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D000078764:Milnacipran; D009020:Morphine / Q000627:therapeutic use; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D014147:Tramadol / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use
chemical_list: D000588:Amines; D000700:Analgesics; D000970:Antineoplastic Agents; D003509:Cyclohexanecarboxylic Acids; D003521:Cyclopropanes; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D008801:Mexiletine; D014147:Tramadol; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D009020:Morphine; D000078764:Milnacipran; D002125:Calcium Gluconate