title: Effect of daily versus once-weekly home fortification with micronutrient Sprinkles on hemoglobin and iron status among young children in rural Bangladesh.
abstract: BACKGROUND
  The effectiveness of commonly suggested public health interventions to control childhood iron-deficiency anemia has been low.
  
  
  OBJECTIVE
  To determine whether iron provided in Sprinkles daily or in a higher dose once weekly affected hemoglobin, serum ferritin levels, and serum transferrin receptor levels, and to determine whether there were differences in the effects of the two regimens.
  
  
  METHODS
  In this cluster-randomized, community-based trial conducted in rural areas of Bangladesh, 136 children aged 12 to 24 months with mild to moderate anemia (hemoglobin 70-109 g/L) were randomly allocated to receive Sprinkles daily (12.5 mg of elemental iron, n = 79) or once weekly (30 mg of elemental iron, n = 73) for 8 weeks. Hemoglobin, serum ferritin, and serum transferrin receptor were assessed at the start and end of the intervention.
  
  
  RESULTS
  In both groups, there were significant increases in hemoglobin and serum ferritin and a significant decrease in serum transferrin receptor (p < .01). There were no significant differences between the groups in the increases in hemoglobin (16.1 +/- 13.2 g/L for the group receiving Sprinkles daily and 12.3 +/- 13.3 g/L for the group receiving Sprinkles once weekly) and serum ferritin (10.6 and 5.7 microg/L, respectively). The decrease in serum transferrin receptor also did not significantly differ between the groups (median, -2.5 and -1.8 mg/L, respectively). The prevalence rates of iron-deficiency anemia, depleted iron stores, and tissue iron deficiency decreased significantly within each group (p < .01), with no significant differences between the groups.
  
  
  CONCLUSIONS
  Home fortification of complementary foods with Sprinkles given either daily or once weekly improved iron-deficiency anemia and iron status among young children.
authors.forename: S M Ziauddin
authors.initials: SM
authors.lastname: Hyder
authors.forename: Farhana
authors.initials: F
authors.lastname: Haseen
authors.forename: Mizanur
authors.initials: M
authors.lastname: Rahman
authors.forename: Mélody C
authors.initials: MC
authors.lastname: Tondeur
authors.forename: Stanley H
authors.initials: SH
authors.lastname: Zlotkin
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000453:epidemiology; D001459:Bangladesh / Q000453:epidemiology; D019587:Dietary Supplements; D005260:Female; D005293:Ferritins / Q000097:blood*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007223:Infant; D019266:Iron, Dietary / Q000008:administration & dosage*; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage; D009752:Nutritional Status; D010349:Patient Compliance; D011990:Receptors, Transferrin / Q000097:blood*; D012424:Rural Population
chemical_list: D006454:Hemoglobins; D019266:Iron, Dietary; D018977:Micronutrients; D011990:Receptors, Transferrin; D005293:Ferritins