title: Diagnostic accuracy of copeptin sensitivity and specificity in patients with suspected non-ST-elevation myocardial infarction with troponin I below the 99th centile at presentation.
abstract: OBJECTIVE
  To determine whether copeptin-us can rule out diagnosis of non-ST-segment elevation myocardial infarction (NSTEMI) without prolonged monitoring and serial blood sampling in patients with high-sensitive cardiac troponin I (hs-cTnI) below the 99th centile at presentation to the emergency department (ED) [corrected].
  
  
  METHODS
  Prospective, non-randomised, individual blinded diagnostic accuracy study.
  
  
  METHODS
  Two EDs of a rural region of France.
  
  
  METHODS
  Patients with chest pain suspected of NSTEMI with onset within the last 12 h were considered for enrollment.
  
  
  METHODS
  Serial clinical, electrographical and biochemical investigations were performed at admission and after 2, 4, 6 and 12 h. Hs-cTnI was measured using an assay with Dimension VISTA, Siemens [corrected]. Copeptin was measured by the BRAHMS copeptin-us assay on the KRYPTOR Compact Plus system. The follow-up period was 90 days.
  
  
  METHODS
  Copeptin, troponin, myoglobin and creatine kinase values. Clinical and paraclinical events. The final diagnosis was adjudicated blinded to copeptin result.
  
  
  RESULTS
  During 12 months, 102 patients were analysed. Final diagnosis was NSTEMI for 7.8% (n=8), unstable angina for 3.9% (n=4), cardiac but non-coronary artery disease for 8.8% (n=9), non-cardiac chest pain for 52% (n=53) and unknown for 27.5% (n=28). There was no statistical difference for copeptin values between patients with NSTEMI and others (respectively 5.5 pmol/L IQR (3.1-7.9) and 6.5 pmol/L IQR (3.9-12.1), p=0.49). Only one patient with NSTEMI had a copeptin value above the cut-off of 95th centile at admission.
  
  
  CONCLUSIONS
  In this study, copeptin does not add a diagnostic value at admission to ED for patients with suspected acute coronary syndrome without ST-segment elevation and with hs-cTnI below the 99th centile [corrected].
  
  
  BACKGROUND
  Clinicaltrials.gov identifier: NCT01334645.
authors.affiliation: Emergency Department, Henri Mondor Hospital, Aurillac, France. j.duchenne@ch-aurillac.fr
authors.forename: Jonathan
authors.initials: J
authors.lastname: Duchenne
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Mestres
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dublanchet
authors.forename: Nicolas
authors.initials: N
authors.lastname: Combaret
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Marceau
authors.forename: Laurent
authors.initials: L
authors.lastname: Caumon
authors.forename: Laurent
authors.initials: L
authors.lastname: Dutoit
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ughetto
authors.forename: Pascal
authors.initials: P
authors.lastname: Motreff
authors.forename: Vincent
authors.initials: V
authors.lastname: Sapin
authors.forename: Jeannot
authors.initials: J
authors.lastname: Schmidt
keywords: Accident & Emergency Medicine