title: Effect of articulatory rehabilitation after oral cancer surgery on higher brain activation.
abstract: The present study aimed to verify the importance of postoperative articulatory rehabilitation in patients with oral cancer and to clarify the neurological changes underlying articulatory functional recovery. A longitudinal assessment of oral function and accompanying brain activity was performed using non-invasive functional magnetic resonance imaging (fMRI). We assessed 13 patients with cancers of the tongue and oral floor before and after ablative surgery. Articulatory function was assessed preoperatively and postoperatively using a conversation intelligibility test and the Assessment of Motor Speech for Dysarthria test. Patients also performed a verbal task during fMRI scans. The assessments were then repeated after the patients had undergone 4-6 months of articulatory rehabilitation therapy. Compared to pretreatment levels, articulatory rehabilitation resulted in a significant increase in activation in the supplementary motor cortex, thalamus, and cingulate cortex. The present study offers a quantitative assessment of the effects of speech rehabilitation by investigating changes in brain activation sites.
authors.affiliation: Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan. Electronic address: naruo@jichi.ac.jp.
authors.forename: N
authors.initials: N
authors.lastname: Okada
authors.affiliation: Department of Craniofacial Growth and Development Dentistry, Kanagawa Dental College, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sasaguri
authors.affiliation: Department of Craniofacial Growth and Development Dentistry, Kanagawa Dental College, Kanagawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Otsuka
authors.affiliation: Department of Radiology, Jichi Medical University, Tochigi, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Fujita
authors.affiliation: Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.affiliation: Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
authors.affiliation: Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Jinbu
authors.affiliation: Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kusama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000503:physiopathology* / Q000601:surgery*; D019647:Oral Surgical Procedures; D020127:Recovery of Function; D013064:Speech Disorders / Q000503:physiopathology* / Q000534:rehabilitation*; D013065:Speech Intelligibility; D016896:Treatment Outcome
keywords: articulatory rehabilitation; functional magnetic resonance imaging; oral cancer surgery