title: Effects of Momordica charantia L. on the blood rheological properties in diabetic patients.
abstract: An evaluation of the rheological properties and the effects of Momordica. charantia L. (M. charantia) nanoparticles and polyethylene glycol (PEG) microspheres adsorbed with M. charantia nanoparticles on the blood of hyperglycemic patients is presented. Blood samples were collected according to glycemic status: normoglycemic (N = 56) and hyperglycemic (N = 26). General and hematological characteristics were determined. Blood rheological parameters were determined at room temperature and under a temperature scan. We determined the effects on whole blood viscosity of treatment with an extract of M. charantia, PEG, or PEG microspheres adsorbed with plant extract. The viscosity of the blood of hyperglycemic patients is greater than that of normoglycemic patients. Nanoparticles of M. charantia extracts lowered blood viscosity at equivalent rates in normo- and hyperglycemic individuals. PEG microspheres did not reduce blood viscosity in hyperglycemic individuals. However, PEG microspheres adsorbed with nanofraction extracts of M. charantia reduced blood viscosity. These data suggest that the effects of diabetes on the viscosity of the blood should be considered. The use of a nanoparticles extract of M. charantia and its adsorption on PEG microspheres may represent an alternative for the control and treatment of blood disorders in diabetic patients.
authors.affiliation: Institute of Biological and Health Science, Federal University of Mato Grosso (UFMT), Rodovia BR070, Km 5 s/n º , 78600-000 Barra do Garças-MT, Brazil.
authors.forename: Eduardo Luzía
authors.initials: EL
authors.lastname: França
authors.affiliation: Institute of Biological and Health Science, Federal University of Mato Grosso (UFMT), Rodovia BR070, Km 5 s/n º , 78600-000 Barra do Garças-MT, Brazil.
authors.forename: Elton Brito
authors.initials: EB
authors.lastname: Ribeiro
authors.affiliation: Institute of Biological and Health Science, Federal University of Mato Grosso (UFMT), Rodovia BR070, Km 5 s/n º , 78600-000 Barra do Garças-MT, Brazil.
authors.forename: Edson Fredulin
authors.initials: EF
authors.lastname: Scherer
authors.affiliation: Institute of Biological and Health Science, Federal University of Mato Grosso (UFMT), Rodovia BR070, Km 5 s/n º , 78600-000 Barra do Garças-MT, Brazil.
authors.forename: Déborah Giovanna
authors.initials: DG
authors.lastname: Cantarini
authors.affiliation: Institute of Biological and Health Science, Federal University of Mato Grosso (UFMT), Rodovia BR070, Km 5 s/n º , 78600-000 Barra do Garças-MT, Brazil.
authors.forename: Rafael Souza
authors.initials: RS
authors.lastname: Pessôa
authors.affiliation: Federal University of Ouro Preto, Ouro Preto, MG, Brazil.
authors.forename: Fernando Luzía
authors.initials: FL
authors.lastname: França
authors.affiliation: Institute of Biological and Health Science, Federal University of Mato Grosso (UFMT), Rodovia BR070, Km 5 s/n º , 78600-000 Barra do Garças-MT, Brazil.
authors.forename: Adenilda Cristina
authors.initials: AC
authors.lastname: Honorio-França
mesh_terms: D000328:Adult; D001809:Blood Viscosity / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D018056:Hemorheology / Q000187:drug effects*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood; D008875:Middle Aged; D029777:Momordica charantia / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D013696:Temperature
chemical_list: D010936:Plant Extracts