title: Effect of troxerutin on synaptic plasticity of hippocampal dentate gyrus neurons in a β-amyloid model of Alzheimer׳s disease: an electrophysiological study.
abstract: Alzheimer׳s disease (AD) is a neurodegenerative disorder with a progressive cognitive decline and memory loss. Multiple pathogenetic factors including aggregated β-amyloid (Aβ), neurofibrillary tangles (NFTs), cholinergic dysfunction and oxidative stress are involved in AD. Aβ, a major constituent of the senile plaques, is a potent neurotoxic peptide and has a pivotal role in cognitive deficit and reduced synaptic plasticity in AD. In the present study we examined the protective effect of troxerutin, as a multipotent bioflavonoid, on Aβ (1-42)-induced impairment of evoked field potential in hippocampal DG neurons. Male Wistar rats were divided into four groups including Aβ (42-1), Aβ (1-42), Aβ (1-42) plus troxerutin and Aβ (42-1) plus troxerutin groups. Aβ was injected intracerebroventricularly (i.c.v.) into right lateral ventricle and after two weeks the evoked field potential recorded from perforant path-DG synapses to assess paired pulse paradigm and long term potentiation (LTP). Administration of Aβ (1-42) drastically attenuated the LTP of DG neurons, while there was no significant difference in evoked field potentials between Aβ (1-42) plus troxerutin group with respect to Aβ (42-1) group. This study revealed that troxerutin improves the synaptic failure induced by Aβ peptide and can be introduced as a promising multi-potent pharmacological agent in prevention or treatment of AD in the future.
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Babri
authors.affiliation: Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Gisou
authors.initials: G
authors.lastname: Mohaddes
authors.affiliation: Department of Surgery, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Feizi
authors.affiliation: Department of Basic Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mohammadnia
authors.affiliation: Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Niapour
authors.affiliation: Department of Histology and Embryology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Alihemmati
authors.affiliation: Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, P.O. Box 56189-53142 Ardabil, Iran. Electronic address: mohammad.amani@arums.ac.ir.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Amani
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D016229:Amyloid beta-Peptides; D000818:Animals; D018891:Dentate Gyrus / Q000473:pathology*; D055724:Electrophysiological Phenomena / Q000187:drug effects; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives* / Q000494:pharmacology; D017774:Long-Term Potentiation / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control / Q000523:psychology; D009473:Neuronal Plasticity / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects
chemical_list: D016229:Amyloid beta-Peptides; D006896:Hydroxyethylrutoside; D018696:Neuroprotective Agents; C005865:troxerutin
keywords: Alzheimer׳s disease; Dentate gyrus; Synaptic plasticity; Troxerutin; β-Amyloid