title: Analysis of macular and peripapillary choroidal thickness in glaucoma patients by enhanced depth imaging optical coherence tomography.
abstract: BACKGROUND
  To compare the macular and peripapillary choroidal thickness between normal and glaucoma eyes and find out factors related to choroidal thickness using enhanced depth imaging (EDI) of Heidelberg Spectralis SD-OCT.
  
  
  METHODS
  Cross-sectional transverse study.
  
  
  METHODS
  A total of 108 glaucoma patients and 48 healthy controls were included in the analysis. Choroidal thickness was measured from 6 mm length radial B-scans at the macular and the optic nerve head by EDI OCT. Choroidal thickness was compared between normal controls, normal tension glaucoma (NTG) patients, and primary open-angle glaucoma (POAG) patients. Factors related to choroidal thickness were analyzed by regression analysis.
  
  
  RESULTS
  There were no differences in average, temporal, nasal, superior, and inferior macular choroidal thickness between normal, NTG, and POAG eyes. The peripapillary thickness did not differ between normal and POAG eyes; however, average, temporal, nasal, superior, and inferior peripapillary choroidal thickness were significantly thinner in NTG eyes. Axial length (β=-11.36, P<0.001) was the most significant factor associated with peripapillary choroidal thickness, followed by age (β=-5.10, P<0.001). Glaucoma type (β=-11.28, P<0.001) were also significantly associated with peripapillary choroidal thickness.
  
  
  CONCLUSIONS
  Peripapillary choroidal thickness was significantly reduced in NTG eyes based on EDI OCT measurements in vivo.
authors.affiliation: *Department of Ophthalmology and Visual Science, Seoul St Mary's Hospital †Department of Ophthalmology and Visual Science, Incheon St Mary's Hospital ‡Department of Ophthalmology and Visual Science, Uijeongbu St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Hae-Young Lopilly
authors.initials: HY
authors.lastname: Park
authors.forename: Na-Young
authors.initials: NY
authors.lastname: Lee
authors.forename: Hae-Young
authors.initials: HY
authors.lastname: Shin
authors.forename: Chan Kee
authors.initials: CK
authors.lastname: Park
mesh_terms: D002829:Choroid / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications* / Q000175:diagnosis; D006068:Gonioscopy; D064368:Healthy Volunteers; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D057066:Low Tension Glaucoma / Q000150:complications* / Q000175:diagnosis; D008266:Macula Lutea; D008297:Male; D008875:Middle Aged; D009898:Optic Disk; D009929:Organ Size; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology