title: Comparison of predictive value of cardiometabolic indices for subclinical atherosclerosis in Chinese adults.
abstract: OBJECTIVE
  Metabolic disturbances are well-known risk factors for atherosclerosis, but it remains unclear which cardiometabolic components are the predominant determinants. This study aimed to compare and identify the key determinants of carotid atherosclerosis in asymptomatic middle-aged and elderly Chinese.
  
  
  METHODS
  A community-based cross-sectional study including 3,162 apparently healthy residents aged 37-75 years was performed from July 2008 to June 2010 in Guangzhou, China. Carotid artery intima-media thickness (IMT) was assessed by B-mode ultrasound, and increased IMT was defined as IMT>1.00 mm. Obesity indices, blood pressure, fasting blood lipids, glucose and uric acid levels were determined. Principal components factor analysis was used to extract common factors underlying 11 metabolic factors.
  
  
  RESULTS
  Four common factors, defined as "adiposity," "blood lipids," "triglycerides/uric acid (TG/UA)" (in men) or "triglycerides/uric acid/glucose (TG/UA/Glu)" (in women), and "blood pressure," were retained for both sexes. After adjustment for potential covariates, the "adiposity" factor showed the strongest positive association with increased IMT in men. Comparing the extreme quartiles, ORs (95% CI) of increased IMT were 4.64 (2.04-10.59) at the CCA and 2.37 (1.54-3.64) at the BIF), followed by "blood pressure", the corresponding OR (95% CI) was 2.85 (1.37-5.90) at the CCA. Whereas, the four common factors showed comparable and weak relationship with increased IMTs, the ORs for quartile 4 vs. quartile 1 varied from 0.89 to 3.59 in women.
  
  
  CONCLUSIONS
  Among the metabolic factors, "adiposity" and "blood pressure" play predominant roles in the presence of carotid atherosclerosis in men, but no key factor is identified in women.
authors.affiliation: Guangdong Provincial Key Laboratory of Food, School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Guangdong Provincial Key Laboratory of Food, School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Fang-fang
authors.initials: FF
authors.lastname: Zeng
authors.affiliation: Guangdong Provincial Key Laboratory of Food, School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China; Guangzhou Panyu Central Hospital, Guangzhou, People's Republic of China.
authors.forename: Li-ping
authors.initials: LP
authors.lastname: He
authors.affiliation: Guangdong Provincial Key Laboratory of Food, School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Wen-hua
authors.initials: WH
authors.lastname: Ling
authors.affiliation: Guangdong Provincial Key Laboratory of Food, School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Wei-qing
authors.initials: WQ
authors.lastname: Chen
authors.affiliation: Guangdong Provincial Key Laboratory of Food, School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Chen
mesh_terms: D050154:Adiposity; D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases; D050197:Atherosclerosis / Q000175:diagnosis* / Q000378:metabolism*; D001794:Blood Pressure; D059168:Carotid Intima-Media Thickness; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D055442:Metabolome; D055432:Metabolomics; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D016017:Odds Ratio; D011379:Prognosis; D012307:Risk Factors
chemical_list: D008055:Lipids