title: Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation.
abstract: Multiple sclerosis (MS) is a progressive degenerative disorder of the central nervous system (CNS), characterized by inflammation, demyelination and axonal loss. While the majority of MS patients experience relapsing-remitting symptoms followed by a secondary progressive phase, about 10-15% patients exhibit a primary progressive disease involving continuous progression from its onset. Here we review the role of lectin-glycan recognition systems, including those concerning siglecs, C-type lectins and galectins in the pathogenesis of MS and experimental autoimmune encephalomyelitis. Particularly, we will focus on the role of galectins in the fate of T cells, dendritic cells and CNS cell populations. Understanding the regulatory circuits governed by lectin-glycan interactions and their association with disease-associated cytokine networks will contribute to develop novel therapeutic strategies in MS.
authors.affiliation: Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), C1428 Buenos Aires, Argentina.
authors.forename: Santiago P
authors.initials: SP
authors.lastname: Mendez-Huergo
authors.affiliation: Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), C1428 Buenos Aires, Argentina.
authors.forename: Sebastián M
authors.initials: SM
authors.lastname: Maller
authors.affiliation: Departamento de Neurología, Instituto de Investigaciones Neurológicas Dr. Raúl Carrea, FLENI, C1428 Buenos Aires, Argentina.
authors.forename: Mauricio F
authors.initials: MF
authors.lastname: Farez
authors.affiliation: Laboratorio de Glicómica Funcional y Molecular, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), C1428 Buenos Aires, Argentina.
authors.forename: Karina
authors.initials: K
authors.lastname: Mariño
authors.affiliation: Departamento de Neurología, Instituto de Investigaciones Neurológicas Dr. Raúl Carrea, FLENI, C1428 Buenos Aires, Argentina.
authors.forename: Jorge
authors.initials: J
authors.lastname: Correale
authors.affiliation: Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), C1428 Buenos Aires, Argentina; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428 Buenos Aires, Argentina. Electronic address: gabriel.r@ibyme.conicet.gov.ar.
authors.forename: Gabriel A
authors.initials: GA
authors.lastname: Rabinovich
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology / Q000473:pathology; D037161:Galectins / Q000276:immunology*; D006801:Humans; D037181:Lectins, C-Type / Q000276:immunology*; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology; D011134:Polysaccharides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D016207:Cytokines; D037161:Galectins; D037181:Lectins, C-Type; D011134:Polysaccharides
keywords: C-type lectins; Galectins; Glycans; Multiple sclerosis; Siglecs