title: Cationic Ir/Me-BIPAM-catalyzed asymmetric intramolecular direct hydroarylation of α-ketoamides.
abstract: Asymmetric intramolecular direct hydroarylation of α-ketoamides gives various types of optically active 3-substituted 3-hydroxy-2-oxindoles in high yields with complete regioselectivity and high enantioselectivities (84-98% ee). This is realized by the use of the cationic iridium complex [Ir(cod)₂](BAr(F)₄) and the chiral O-linked bidentate phosphoramidite (R,R)-Me-BIPAM.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Shirai
authors.forename: Hajime
authors.initials: H
authors.lastname: Ito
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D002412:Cations / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D000078183:Oxindoles
chemical_list: D000577:Amides; D002412:Cations; D007211:Indoles; D009943:Organophosphorus Compounds; D000078183:Oxindoles; C434331:phosphoramidite; C022960:2-oxindole; D007495:Iridium