title: Synchrotron-based X-ray-sensitive nanoprobes for cellular imaging.
abstract: It is one of the ultimate goals in cell biology to understand the complex spatio-temporal interplay of biomolecules in the cellular context. To this end, there have been great efforts on the development of various probes to detect and localize specific biomolecules in cells with a variety of microscopic imaging techniques. In this Research News, we first summarize several types of microscopy for visualizing specific biomolecular targets. Then we focus on recent advances in the design of X-ray sensitive nanoprobes for applications in synchrotron-based cellular imaging. With the availability of advanced synchrotron techniques, there has been rapid progress toward high-resolution and multi-color X-ray imaging in cells with various types of functional nanoprobes.
authors.affiliation: Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Thomas
authors.initials: T
authors.lastname: Earnest
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Cai
authors.forename: Zhili
authors.initials: Z
authors.lastname: Wang
authors.forename: Ziyu
authors.initials: Z
authors.lastname: Wu
authors.forename: Chunhai
authors.initials: C
authors.lastname: Fan
mesh_terms: D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D018625:Microscopy, Atomic Force; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism; D045663:Quantum Dots / Q000737:chemistry; D017356:Synchrotrons
chemical_list: D005456:Fluorescent Dyes
keywords: inverted device architecture; organic light emitting diode; solution processing; transparent; zinc oxide