title: Rho GTPases at the crossroad of signaling networks in mammals: impact of Rho-GTPases on microtubule organization and dynamics.
abstract: Microtubule (MT) organization and dynamics downstream of external cues is crucial for maintaining cellular architecture and the generation of cell asymmetries. In interphase cells RhoA, Rac, and Cdc42, conspicuous members of the family of small Rho GTPases, have major roles in modulating MT stability, and hence polarized cell behaviors. However, MTs are not mere targets of Rho GTPases, but also serve as signaling platforms coupling MT dynamics to Rho GTPase activation in a variety of cellular conditions. In this article, we review some of the key studies describing the reciprocal relationship between small Rho-GTPases and MTs during migration and polarization.
authors.affiliation: Laboratory of Neurobiology; Instituto Mercedes y Martin Ferreyra (INIMEC) CONICET; Córdoba, Argentina.
authors.forename: José
authors.initials: J
authors.lastname: Wojnacki
authors.affiliation: Laboratory of Neurobiology; Instituto Mercedes y Martin Ferreyra (INIMEC) CONICET; Córdoba, Argentina.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Quassollo
authors.affiliation: Laboratorio de Tráfico Intracelular y Señalización; Departamento de Biología Celular y Molecular; Facultad de Ciencias Biológicas; Pontificia Universidad Católica de Chile; Santiago, Chile.
authors.forename: María-Paz
authors.initials: MP
authors.lastname: Marzolo
authors.affiliation: Laboratory of Neurobiology; Instituto Mercedes y Martin Ferreyra (INIMEC) CONICET; Córdoba, Argentina; Universidad Nacional Córdoba (UNC); Córdoba, Argentina; Instituto Universitario Ciencias Biomédicas Córdoba (IUCBC); Córdoba-Argentina.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Cáceres
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D016764:Cell Polarity; D022001:Focal Adhesions / Q000378:metabolism; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D015398:Signal Transduction; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D008869:Microtubule-Associated Proteins; D020764:cdc42 GTP-Binding Protein; D020741:rho GTP-Binding Proteins
keywords: actin filaments; microtubules; migration; polarity; protrusion; small GTPases; stabilization