title: The relationship of sex hormone-binding globulin (SHBG) gene polymorphisms with serum SHBG level and metabolic syndrome in Chinese Han males.
abstract: OBJECTIVE
  Epidemiological studies have shown that circulating sex hormone-binding globulin (SHBG) levels are lower in metabolic syndrome (MetS) patients than in non-MetS individuals. In this study, we investigated the relationship of polymorphisms in the SHBG gene with the serum SHBG levels and MetS in Han Chinese.
  
  
  METHODS
  We performed a cross-sectional study of 316 subjects who were recruited from a health checkup population at Zhongshan Hospital, Fudan University. Anthropometric measurements, blood pressure, fasting plasma glucose, lipid levels, total testosterone, and SHBG levels were obtained in addition to the seven SHBG single-nucleotide polymorphisms (SNPs).
  
  
  RESULTS
  The variant allele (AG or AA) carriers in rs6259, compared to the wild-type allele carriers (GG), have a lower risk for MetS [OR 0.56, 95% confidence interval (CI) 0.33-0.96] and higher serum SHBG and TT levels (P = 0.016, 0.004). CT or TT allele carriers in rs3760213, compared to CC allele carriers, also have a lower risk for MetS (OR 0.59, 95 % CI 0.34-1.00) and significantly higher SHBG and TT levels (P = 0.029, 0.009). Carriers having both of the variant alleles had the lowest risk of MetS (OR 0.51, 95 % CI 0.275-0.950) and the highest SHBG levels. The risk of MetS rose with the decrease in serum SHBG levels for rs6259 and rs376021 carriers.
  
  
  CONCLUSIONS
  rs6259 and rs3760213 SNPs are associated with the risk of MetS and lower serum SHBG level in Chinese Han males.
authors.affiliation: Department of Geriatrics, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Pang
authors.forename: Ying
authors.initials: Y
authors.lastname: Yuan
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Ji-Ping
authors.initials: JP
authors.lastname: Shen
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Zha
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D003430:Cross-Sectional Studies; D005838:Genotype; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000235:genetics* / Q000378:metabolism*
chemical_list: D012738:Sex Hormone-Binding Globulin