title: Prognostic factors affecting survival in malignant pleural mesothelioma: analysis of 125 subjects.
abstract: OBJECTIVE
  Determining the pre-treatment prognostic factors in malignant pleural mesothelioma is important in terms of estimating the course of the disease and selecting patients who are candidate for multimodal therapy. The aim of the study was to determine the prognostic factors affecting survival in patients with malignant pleural mesothelioma.
  
  
  METHODS
  One hundred and twenty-five patients who had been diagnosed histologically as having malignant pleural mesothelioma over the past 5 years were evaluated retrospectively. Relationships of survival of the patients with their age, gender, exposure to asbestos, smoking history, platelet, hemoglobin, leukocyte (WBC) and serum LDH values, histology, performance score and stage of disease were examined.
  
  
  RESULTS
  Advanced clinical stage, N2 nodal involvement and the presence of distant metastasis were found to be related to survival. Sarcomatous histology was found to be a poor prognostic factor independently of other factors.
  
  
  CONCLUSIONS
  We showed that histological subtype and stage of disease were the most important parameters in planning the treatment, especially in determining the patients who were candidate for multimodal treatment and in estimating the prognosis.
authors.forename: Berna
authors.initials: B
authors.lastname: Komurcuoglu
authors.forename: A Kadri
authors.initials: AK
authors.lastname: Cirak
authors.forename: S Cenk
authors.initials: SC
authors.lastname: Kirakli
authors.forename: Gulru
authors.initials: G
authors.lastname: Polat
authors.forename: Nur
authors.initials: N
authors.lastname: Yucel
authors.forename: Ozan
authors.initials: O
authors.lastname: Usluer
authors.forename: Onur
authors.initials: O
authors.lastname: Erer
authors.forename: Gunseli
authors.initials: G
authors.lastname: Balci
authors.forename: Mine
authors.initials: M
authors.lastname: Gayaf
authors.forename: Filiz
authors.initials: F
authors.lastname: Guldaval
authors.forename: Serir
authors.initials: S
authors.lastname: Aktogu
authors.forename: Salih
authors.initials: S
authors.lastname: Guclu
authors.forename: Ayse
authors.initials: A
authors.lastname: Ozsoz
authors.forename: Huseyin
authors.initials: H
authors.lastname: Halilcolar
mesh_terms: D000367:Age Factors; D000368:Aged; D001194:Asbestos / Q000633:toxicity; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008654:Mesothelioma / Q000097:blood / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D009367:Neoplasm Staging; D010997:Pleural Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D014421:Turkey / Q000453:epidemiology
chemical_list: D001194:Asbestos