title: Serum levels of fractalkine are associated with markers of insulin resistance in gestational diabetes.
abstract: OBJECTIVE
  Fractalkine has recently been introduced as an adipokine that improves glucose tolerance. Regulation of fractalkine in gestational diabetes, as well as its association with markers of obesity, glucose and lipid metabolism, inflammation and renal function, has not been elucidated.
  
  
  METHODS
  Circulating fractalkine was quantified by enzyme-linked immunosorbent assay in 74 women with gestational diabetes and 74 healthy, pregnant control subjects matched for age, BMI, and gestational age.
  
  
  RESULTS
  Median (interquartile range) levels of fractalkine were not significantly different between the two groups [gestational diabetes: 2.24 (2.16) μg/l; control: 2.45 (1.38) μg/l] (P = 0.461). In multivariate linear regression analysis, fractalkine remained independently associated with homeostasis model assessment of insulin resistance (β = -0.253, P = 0.002) and the proinflammatory adipokine progranulin (β = 0.218, P = 0.007).
  
  
  CONCLUSIONS
  Circulating fractalkine is not different between women with gestational diabetes and control subjects, but the adipokine is independently associated with markers of insulin resistance and proinflammatory progranulin in pregnancy.
authors.affiliation: Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany; IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Ebert
authors.forename: J
authors.initials: J
authors.lastname: Hindricks
authors.forename: S
authors.initials: S
authors.lastname: Kralisch
authors.forename: U
authors.initials: U
authors.lastname: Lossner
authors.forename: B
authors.initials: B
authors.lastname: Jessnitzer
authors.forename: J
authors.initials: J
authors.lastname: Richter
authors.forename: M
authors.initials: M
authors.lastname: Blüher
authors.forename: M
authors.initials: M
authors.lastname: Stumvoll
authors.forename: M
authors.initials: M
authors.lastname: Fasshauer
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D054428:Chemokine CX3CL1 / Q000097:blood*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood* / Q000378:metabolism; D005260:Female; D005858:Germany; D005951:Glucose Tolerance Test; D006785:Hospitals, University; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D010044:Outpatient Clinics, Hospital; D011247:Pregnancy; D000077153:Progranulins; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D015415:Biomarkers; C515538:CX3CL1 protein, human; D054428:Chemokine CX3CL1; C492314:GRN protein, human; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins