title: Further mulinane and azorellane diterpenoids isolated from Mulinum crassifolium and Azorella compacta.
abstract: The new mulinane diterpenoids 1 and 2 were isolated from the EtOAc extract of Mulinum crassifolium, while the rearranged mulinane 5, which was isolated for the first time from a natural source, was isolated from Azorella compacta. Compounds 1-2 were prepared by semi-synthesis thorough acetylation of the diterpene 17-acetoxymulinic acid (3). A mechanism of reaction was proposed, while the structures of the new compounds were elucidated on the basis of comprehensive spectroscopic analysis and computational methods.
authors.affiliation: Laboratorio de Productos Naturales, Departamento de Química, Universidad de Antofagasta, Av. Coloso S-N, Antofagasta 1240000, Chile. jorge.borquez@uantof.cl.
authors.forename: Jorge
authors.initials: J
authors.lastname: Bórquez
authors.affiliation: Laboratorio de Productos Naturales, Departamento de Química, Universidad de Antofagasta, Av. Coloso S-N, Antofagasta 1240000, Chile. euro_ale@hotmail.com.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Ardiles
authors.affiliation: Laboratorio de Productos Naturales, Departamento de Química, Universidad de Antofagasta, Av. Coloso S-N, Antofagasta 1240000, Chile. alberto.loyola@uantof.cl.
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: Loyola
authors.affiliation: Grupo de Química Orgánica, Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43 No 130, Colonia Chuburná, Mérida, Yucatán 97200, Mexico. luispenarodriguez@yahoo.com.
authors.forename: Luis Manuel
authors.initials: LM
authors.lastname: Peña-Rodriguez
authors.affiliation: División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, San Luis Potosí y Dos de Abril, Colonia Independencia, Monterrey, Nuevo León 64720, Mexico. gmolina70@gmail.com.
authors.forename: Gloria María
authors.initials: GM
authors.lastname: Molina-Salinas
authors.affiliation: Departamento de Química, Universidad Católica del Norte, Av. Angamos 610, Antofagasta 1240000, Chile. jvallejos01@ucn.cl.
authors.forename: Javier
authors.initials: J
authors.lastname: Vallejos
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Apartado Postal 40, Puerto Real 11510, Spain. isidro.gonzalez@uca.es.
authors.forename: Isidro G
authors.initials: IG
authors.lastname: Collado
authors.affiliation: Laboratorio de Productos Naturales, Departamento de Química, Universidad de Antofagasta, Av. Coloso S-N, Antofagasta 1240000, Chile. mario.simirgiotis@uantof.cl.
authors.forename: Mario J
authors.initials: MJ
authors.lastname: Simirgiotis
mesh_terms: D019661:Apiaceae / Q000737:chemistry*; D019659:Asteraceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D004224:Diterpenes; D010936:Plant Extracts; C546876:azorellane; C113748:mulinane