title: Aldosterone to active renin ratio is associated with nocturnal blood pressure in obese and treated hypertensive patients: the Styrian Hypertension Study.
abstract: High aldosterone levels are considered to play a key role in arterial hypertension. Data on the relationship between the aldosterone to active renin ratio (AARR), a quantity of aldosterone excess, and ambulatory blood pressure (BP) monitoring (ABPM) during the night are, however, sparse. Hypertensive patients were recruited from local outpatient clinics who underwent 24-hour urine collection and in parallel ABPM. Plasma aldosterone and renin concentrations were measured by radioimmunoassay. A total of 211 patients (age, 60.2±10.2 years; 51.9% female) with a mean systolic/diastolic ABPM value of 128.7±12.8/77.1±9.2 mm Hg were evaluated. In backwards linear regression analyses adjusted for age, sex, body mass index, smoking, glomerular filtration rate, hemoglobin A1c , N-terminal prohormone of brain natriuretic peptide, urinary sodium/potassium ratio, and ongoing antihypertensive medication, AARR was significantly associated with nocturnal systolic (ß-coefficient: 0.177; P=.017) and diastolic BP (ß-coefficient: 0.162; P=.027). In patients with arterial hypertension, a significant association between AARR and nighttime BP even after adjustment for a broad panel of confounders was found.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria; Department of Cardiology, Medical University of Graz, Graz, Austria.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Grübler
authors.forename: Katharina
authors.initials: K
authors.lastname: Kienreich
authors.forename: Martin
authors.initials: M
authors.lastname: Gaksch
authors.forename: Nicolas
authors.initials: N
authors.lastname: Verheyen
authors.forename: Astrid
authors.initials: A
authors.lastname: Fahrleitner-Pammer
authors.forename: Johannes
authors.initials: J
authors.lastname: Schmid
authors.forename: Jana
authors.initials: J
authors.lastname: Grogorenz
authors.forename: Klemens
authors.initials: K
authors.lastname: Ablasser
authors.forename: Burkert
authors.initials: B
authors.lastname: Pieske
authors.forename: Andreas
authors.initials: A
authors.lastname: Tomaschitz
authors.forename: Stefan
authors.initials: S
authors.lastname: Pilz
mesh_terms: D000368:Aged; D000450:Aldosterone / Q000097:blood*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001317:Austria; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D015992:Body Mass Index; D002940:Circadian Rhythm / Q000502:physiology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood*
chemical_list: D000959:Antihypertensive Agents; D000450:Aldosterone; D012083:Renin