title: Structure-function relationships of ErbB RTKs in the plasma membrane of living cells.
abstract: We review the states of the ErbB family of receptor tyrosine kinases (RTKs), primarily the EGF receptor (EGFR, ErbB1, HER1) and the orphan receptor ErbB2 as they exist in living mammalian cells, focusing on four main aspects: (1) aggregation state and distribution in the plasma membrane; (2) conformational features of the receptors situated in the plasma membrane, compared to the crystallographic structures of the isolated extracellular domains; (3) coupling of receptor disposition on filopodia with the transduction of signaling ligand gradients; and (4) ligand-independent receptor activation by application of a magnetic field.
authors.affiliation: Laboratory of Cellular Dynamics, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Arndt-Jovin
authors.forename: Michelle G
authors.initials: MG
authors.lastname: Botelho
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Jovin
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D018360:Crystallography, X-Ray; D008322:Mammals / Q000378:metabolism; D018739:Oncogene Proteins v-erbB / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D066329:Protein Aggregates; D011554:Pseudopodia / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018739:Oncogene Proteins v-erbB; D066329:Protein Aggregates