title: A Pd-based regioselective strategy to indole-1,2-fused 8- and 9-membered rings: their evaluation as potential scaffolds for apoptosis in zebrafish.
abstract: A strategy based on Pd-mediated ring closure of 1,2-disubstituted indoles containing an unactivated olefin leading to indole-1,2-fused 8- and 9-membered rings has been developed for the identification of new and potential scaffolds for apoptosis. A large number of fused indole derivatives containing an endocyclic double bond were synthesized using this robust methodology. A representative compound showed promising apoptotic properties in zebrafish embryos.
authors.affiliation: Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India. manojitpal@rediffmail.com.
authors.forename: Bagineni
authors.initials: B
authors.lastname: Prasad
authors.forename: B Yogi
authors.initials: BY
authors.lastname: Sreenivas
authors.forename: Araka
authors.initials: A
authors.lastname: Sushma
authors.forename: Swapna
authors.initials: S
authors.lastname: Yellanki
authors.forename: Raghavender
authors.initials: R
authors.lastname: Medisetti
authors.forename: Pushkar
authors.initials: P
authors.lastname: Kulkarni
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D015195:Drug Design; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007455:Iodine / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008727:Methotrexate / Q000494:pharmacology; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013997:Time Factors; D015027:Zebrafish / Q000196:embryology / Q000378:metabolism*
chemical_list: D007211:Indoles; D010165:Palladium; D007455:Iodine; D008727:Methotrexate