title: Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM).
abstract: PGRMC1 function is implicated in maintaining fetal membrane (FM) integrity. PGRMC1 was detectable primarily in the cytoplasm of FM cells and was actively regulated in FMs and relevant for PGRMC1-mediated progesterone action. By cell type, PGRMC1 expression was higher in amnion and chorion compared with decidua. By clinical phenotype, PGRMC1 expression was higher among preterm-no-labor and term-no-labor subjects compared to PPROM. PGRMC1 expression appears to be diminished in PPROM subjects.
authors.affiliation: Department of Obstetrics and Gynecology, Duke University, Durham, NC, USA.
authors.forename: L
authors.initials: L
authors.lastname: Feng
authors.affiliation: Department of Obstetrics and Gynecology, Duke University, Durham, NC, USA.
authors.forename: B C
authors.initials: BC
authors.lastname: Antczak
authors.affiliation: Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
authors.forename: L
authors.initials: L
authors.lastname: Lan
authors.affiliation: Department of Obstetrics and Gynecology, Duke University, Durham, NC, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Grotegut
authors.affiliation: Department of Obstetrics and Gynecology, Duke University, Durham, NC, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Thompson
authors.affiliation: Department of Anesthesia, Duke University, Durham, NC, USA.
authors.forename: T K
authors.initials: TK
authors.lastname: Allen
authors.affiliation: Department of Obstetrics and Gynecology, Duke University, Durham, NC, USA. Electronic address: murth002@mc.duke.edu.
authors.forename: A P
authors.initials: AP
authors.lastname: Murtha
mesh_terms: D000650:Amnion / Q000378:metabolism; D002823:Chorion / Q000378:metabolism; D003656:Decidua / Q000378:metabolism; D005321:Extraembryonic Membranes / Q000378:metabolism*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D011247:Pregnancy; D011980:Receptors, Progesterone / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; C115296:PGRMC1 protein, human; D011980:Receptors, Progesterone
keywords: Expression; Fetal membrane cells; PGRMC1; PPROM