title: Regeneration of stalled immune responses to transformed and infected cells using γδ T cells.
abstract: Manipulation of the human immune system is becoming more of a therapeutic focus as a treatment option or complement. Prominent examples are the increasing use of monoclonal antibodies in combating malignant tumours, and the numerous adoptive immunotherapy trials underway. One important aspect of any use of the human immune system in this regard is to harness the power of professional antigen-presenting cells (pAPC), that is, dendritic cells (DC), to direct immune responses. Here, we review how recent findings regarding the biology of γδT cells have revealed that they, surprisingly, could serve as convenient tools for this purpose, in that they combine innate cytotoxic cell and pAPC functions in one cell type, with potential benefits in cancer immunotherapy and infectious disease.
authors.affiliation: Molecular Immunology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
authors.forename: Kenth
authors.initials: K
authors.lastname: Gustafsson
authors.affiliation: Molecular Haematology and Cancer Biology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
authors.forename: John
authors.initials: J
authors.lastname: Anderson
authors.affiliation: Molecular Haematology and Cancer Biology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
authors.forename: Jonathan P H
authors.initials: JPH
authors.lastname: Fisher
authors.affiliation: Molecular Immunology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.|Molecular Haematology and Cancer Biology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
authors.forename: Mengyong
authors.initials: M
authors.lastname: Yan
mesh_terms: D000818:Animals; D002461:Cell Line, Transformed; D003141:Communicable Diseases / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D012038:Regeneration / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000382:microbiology* / Q000473:pathology