title: Two new phenolic compounds from Ficus rumphii and their antiproliferative activity.
abstract: Two new compounds 2 and 4, along with two known compounds 1 and 3, were isolated for the first time from 95% ethanolic extract of the leaves of Ficus rumphii. Their structures were elucidated on the basis of chemical and physical evidences (elemental analysis, UV, IR, (1)H NMR, (13)C NMR and mass spectra) and comparison with the literature compounds. Structural authentication of compound 4 was further validated by single-crystal X-ray analysis and DFT calculations. The compounds 1-4 were screened for in vitro cytotoxicity against cancer and non-cancer cells and also tested for genotoxicity (comet assay). Compounds 2 and 4 displayed significant activity against HL-60 with IC50 values of 3.3 and 2.3 μM, respectively. The results revealed that compound 4 has better prospectus to act as cancer chemotherapeutic candidate which warrants further in vivo anticancer investigations.
authors.affiliation: a Division of Natural Products, Department of Chemistry , Aligarh Muslim University , Aligarh 202002 , India.
authors.forename: Mehtab
authors.initials: M
authors.lastname: Parveen
authors.forename: Ali Mohammed
authors.initials: AM
authors.lastname: Malla
authors.forename: Mahboob
authors.initials: M
authors.lastname: Alam
authors.forename: Faheem
authors.initials: F
authors.lastname: Ahmad
authors.forename: P S Pereira
authors.initials: PS
authors.lastname: Silva
authors.forename: Manuela Ramos
authors.initials: MR
authors.lastname: Silva
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D030681:Ficus / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D007194:India; D020128:Inhibitory Concentration 50; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: C000591767:1-isopentyl-3,4-dioxomethylene-2-phenol; C000591768:3-(2-hydroxyphenyl)-1-(piperidin-1-yl) propan-1-one; D000972:Antineoplastic Agents, Phytogenic; D010636:Phenols; D010880:Piperidines
keywords: Ficus rumphii; X-ray study; anticancer activity; phenolic compounds