title: [Progress in research of the mechanisms related with the hepatic steatosis in the nonalcoholic fatty liver disease].
abstract: With the increased morbidity of Nonalcoholic fatty liver disease, the pathogenesis of which has become one of the focuses for researchers. Many details need to be clarified. The hepatic steatosis has been taken as the clinical pathological characters and the "golden standard of diagnosis" for the nonalcoholic fatty liver disease. More and more studies have shown that the hepatic steatosis (mainly as triglycerides) is the consequence of hepatic lipid metabolism disequilibrium. Generally, the related metabolism pathways including lipid input, lipid uptake, de novo lipogenesis, fatty acid oxidation, fatty acid reesterification, and lipid secretion etc. In this review, we focused on the progress of some key enzymes involved in these pathways in order to clarify the possible molecular mechanisms and the effective targets so that to broad our vision about the prevention and treatment of non-alcoholic fatty liver disease.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Shi
authors.forename: Guang-Yao
authors.initials: GY
authors.lastname: Song
mesh_terms: D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D050155:Lipogenesis; D008099:Liver / Q000503:physiopathology*; D065626:Non-alcoholic Fatty Liver Disease / Q000473:pathology*; D010084:Oxidation-Reduction; D014280:Triglycerides / Q000737:chemistry
chemical_list: D008055:Lipids; D014280:Triglycerides