title: Oral exposure of Kunming mice to diisononyl phthalate induces hepatic and renal tissue injury through the accumulation of ROS. Protective effect of melatonin.
abstract: Diisononyl phthalate (DINP) has been widely used in polyvinyl chloride (PVC) products and is ubiquitous as a substitute; however, its toxicity due to exposure remains to be determined. This study investigated the oxidative damage induced by DINP and the induced production of the pro-inflammation cytokines interleukin-1 (IL-1) and tumour necrosis factor-α (TNF-α). Oral exposure to DINP induced oxidative damage and inflammatory responses in liver and kidney tissues through the accumulation of ROS, which may be an underlying mechanism for its toxicity. These changes may contribute to hepatic and renal histopathological alterations. Our data suggest that oxidative stress is involved in DINP-induced toxicity and that the co-administration of melatonin exerts a protective effect against DINP-induced toxicity.
authors.affiliation: Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular and Metabolic Disorders, Hubei University of Science and Technology, Xianning 437100, China; Hubei Province Key Laboatory of Genetic Regulation and Integrative Biology, Central China Normal Unversity, Wuhan 430079, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Ma
authors.affiliation: Hubei Province Key Laboatory of Genetic Regulation and Integrative Biology, Central China Normal Unversity, Wuhan 430079, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Yan
authors.affiliation: Hubei Province Key Laboatory of Genetic Regulation and Integrative Biology, Central China Normal Unversity, Wuhan 430079, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zeng
authors.affiliation: Hubei Province Key Laboatory of Genetic Regulation and Integrative Biology, Central China Normal Unversity, Wuhan 430079, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular and Metabolic Disorders, Hubei University of Science and Technology, Xianning 437100, China; Hubei Province Key Laboatory of Genetic Regulation and Integrative Biology, Central China Normal Unversity, Wuhan 430079, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular and Metabolic Disorders, Hubei University of Science and Technology, Xianning 437100, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Jiao
authors.affiliation: Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular and Metabolic Disorders, Hubei University of Science and Technology, Xianning 437100, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular and Metabolic Disorders, Hubei University of Science and Technology, Xianning 437100, China. Electronic address: xywJL@163.com.
authors.forename: Jiliang
authors.initials: J
authors.lastname: Wu
authors.affiliation: Hubei Province Key Laboatory of Genetic Regulation and Integrative Biology, Central China Normal Unversity, Wuhan 430079, China. Electronic address: yangxu@mail.ccnu.edu.cn.
authors.forename: Xu
authors.initials: X
authors.lastname: Yang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004249:DNA Damage / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D007375:Interleukin-1 / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D010795:Phthalic Acids / Q000008:administration & dosage* / Q000009:adverse effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D007375:Interleukin-1; D010795:Phthalic Acids; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; C012125:diisononyl phthalate; D008550:Melatonin
keywords: Diisononyl phthalate; Interleukin-1; Melatonin; Oxidative stress; Reactive oxygen species; Tumour necrosis factor α