title: New myxothiazols from the predatory bacterium Myxococcus fulvus.
abstract: Extracts of the predatory bacterium Myxococcus fulvus HKI 722 showed promising antimicrobial activities in the agar diffusion assay. A combined chemical and computational analysis led to the identification of five thiazole-containing antibiotics. Two of the isolated compounds represent previously unrecognized members of the myxothiazol family of natural products. Their antibiotic properties were determined in comparison with those of the known myxothiazols A and Z.
authors.affiliation: Junior Research Group 'Secondary Metabolism of Predatory Bacteria', Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Jena, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Schieferdecker
authors.affiliation: Pharmaceutical Institute, Department of Pharmaceutical Chemistry, University of Tübingen, Tübingen, Germany.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Exner
authors.affiliation: 1] Pharmaceutical Institute, Department of Pharmaceutical Biology, University of Tübingen, Tübingen, Germany [2] German Centre for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Gross
authors.affiliation: Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Jena, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Roth
authors.affiliation: Junior Research Group 'Secondary Metabolism of Predatory Bacteria', Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Jena, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Nett
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D008689:Methacrylates / Q000737:chemistry / Q000494:pharmacology; D016940:Myxococcus / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D008689:Methacrylates; D013844:Thiazoles; C030517:myxothiazol