title: Maternal OGTT glucose levels at 26-30 gestational weeks with offspring growth and development in early infancy.
abstract: OBJECTIVE
  We aim to evaluate the association of maternal gestational oral glucose tolerance test (OGTT) glucose concentrations with anthropometry in the offspring from birth to 12 months in Tianjin, China.
  
  
  METHODS
  A total of 27,157 pregnant women underwent OGTT during 26-30 weeks gestation, and their children had body weight/length measured from birth to 12 months old.
  
  
  RESULTS
  Maternal OGTT glucose concentrations at 26-30 gestational weeks were positively associated with Z-scores for birth length-for-gestational age and birth weight-for-length. Compared with infants born to mothers with normal glucose tolerance, infants born to mothers with gestational diabetes mellitus (impaired glucose tolerance/new diabetes) had higher mean values of Z-scores for birth length-for-gestational age (0.07/0.23; normal group -0.08) and birth weight-for-length (0.27/0.57; normal group -0.001), smaller changes in mean values of Z-scores for length-for-age (0.75/0.62; normal group 0.94) and weight-for-length (0.18/-0.17; normal group 0.37) from birth to month 3, and bigger changes in mean values in Z-scores for weight-for-length (0.07/0.12; normal group 0.02) from month 9 to 12.
  
  
  CONCLUSIONS
  Abnormal maternal glucose tolerance during pregnancy was associated with higher birth weight and birth length, less weight and length gain in the first 3 months of life, and more weight gain in the months 9-12 of life.
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Gongshu
authors.initials: G
authors.lastname: Liu
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China ; Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Shurong
authors.initials: S
authors.lastname: Sun
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wen
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Fengjun
authors.initials: F
authors.lastname: Lyu
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Gao
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Li
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.affiliation: Departments of Epidemiology and Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Baccarelli
authors.affiliation: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Lifang
authors.initials: L
authors.lastname: Hou
authors.affiliation: Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA.
authors.forename: Gang
authors.identifier: 0000-0002-6172-8017
authors.initials: G
authors.lastname: Hu
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001827:Body Height; D001835:Body Weight; D002681:China; D005260:Female; D005865:Gestational Age; D005951:Glucose Tolerance Test; D048788:Growth and Development; D006801:Humans; D007223:Infant; D009035:Mothers; D011247:Pregnancy
chemical_list: D001786:Blood Glucose