title: Food allergen sensitization pattern in adults in relation to severity of atopic dermatitis.
abstract: BACKGROUND
  Limited data are available on the frequency of IgE mediated food sensitization and food allergy (FA) in adults with atopic dermatitis (AD).
  
  
  OBJECTIVE
  We investigated the pattern of food sensitization in adults with AD in relation to AD severity using multiplexed allergen microarray.
  
  
  METHODS
  211 adult patients referred between January 2010-July 2011 for evaluation of AD were unselectively included. Severity of AD was determined by therapy intensity, SASSAD-skin-score and sTARC levels. Allergen specific sIgE levels were measured by ImmunoCAP ISAC® microarray. FA was defined as convincing history taken by physician and sensitization to the corresponding allergen.
  
  
  RESULTS
  Sensitization to food was found in 74.4% of the AD patients, 54% had a positive history of FA and 20.4% asymptomatic sensitization. There was no association between severity of AD and frequency of food sensitization or history of FA.Sensitization to PR-10 related food allergens occurred most frequently (63.5%) and was independent from AD severity. Correspondingly, pollen-food syndrome accounted for most of the FA, being also independent from AD severity. Of all plant food allergens only sensitization to nAra h 1 was significantly more frequent in patients with severe AD. In the total group 75 (35.5%) patients with AD showed sensitization to any animal food allergen. The percentage was significantly higher in patients with severe AD (51.4%) compared to patients with mild/moderate AD (27.7%). Sensitization to cow's milk allergens, in particular to nBos d lactoferrin, was more frequent in severe AD patients.
  
  
  CONCLUSIONS
  AD was frequently associated with food sensitization. The percentage of sensitization to animal food allergens was significantly higher in severe AD patients.
authors.affiliation: Department of Dermatology/Allergology, University Medical Center Utrecht, Heidelberglaan 100, G 02,124, 3584 Utrecht, CX, The Netherlands. h.rockmann@umcutrecht.nl.
authors.forename: Heike
authors.initials: H
authors.lastname: Röckmann
authors.forename: Maartje J
authors.initials: MJ
authors.lastname: van Geel
authors.forename: Andre C
authors.initials: AC
authors.lastname: Knulst
authors.forename: Jorike
authors.initials: J
authors.lastname: Huiskes
authors.forename: Carla Afm
authors.initials: CA
authors.lastname: Bruijnzeel-Koomen
authors.forename: Marjolein S
authors.initials: MS
authors.lastname: de Bruin-Weller