title: Domoic acid epileptic disease.
abstract: Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic epileptic syndrome in California sea lions through investigation of a series of domoic acid poisoning cases between 1998 and 2006. The sea lion study provided a breadth of insight into clinical presentations, unusual behaviors, brain pathology, and epidemiology. A rat model that replicates key observations of the chronic epileptic syndrome in sea lions has been applied to identify the progression of the epileptic disease state, its relationship to behavioral manifestations, and to define the neural systems involved in these behavioral disorders. Here, we present the concept of domoic acid epileptic disease as a delayed manifestation of domoic acid poisoning and review the state of knowledge for this disease state in affected humans and sea lions. We discuss causative mechanisms and neural underpinnings of disease maturation revealed by the rat model to present the concept for olfactory origin of an epileptic disease; triggered in dendodendritic synapases of the olfactory bulb and maturing in the olfactory cortex. We conclude with updated information on populations at risk, medical diagnosis, treatment, and prognosis.
authors.affiliation: Marine Biotoxins Program, Center for Coastal Environmental Health and Biomolecular Research, NOAA, National Ocean Service, Charleston, SC 29414, USA. john.ramsdell@noaa.gov.
authors.forename: John S
authors.initials: JS
authors.lastname: Ramsdell
authors.affiliation: The Marine Mammal Center, 2000 Bunker Road, Marin Headlands, Sausalito, CA 94965, USA. gullandf@tmmc.org.
authors.forename: Frances M
authors.initials: FM
authors.lastname: Gulland
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D000647:Amnesia / Q000139:chemically induced / Q000523:psychology; D000820:Animal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D049872:Bivalvia; D004827:Epilepsy / Q000139:chemically induced* / Q000175:diagnosis / Q000662:veterinary*; D004833:Epilepsy, Temporal Lobe / Q000139:chemically induced / Q000503:physiopathology; D005260:Female; D005506:Food Contamination; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000506:poisoning; D008297:Male; D008387:Marine Toxins / Q000506:poisoning*; D008875:Middle Aged; D009467:Neuromuscular Depolarizing Agents / Q000506:poisoning*; D009498:Neurotoxins / Q000506:poisoning*; D009833:Olfactory Pathways / Q000503:physiopathology; D051381:Rats; D012008:Recurrence; D046070:Sea Lions / Q000502:physiology*; D012640:Seizures / Q000139:chemically induced / Q000175:diagnosis / Q000662:veterinary*; D057096:Shellfish Poisoning / Q000175:diagnosis / Q000503:physiopathology* / Q000662:veterinary*
chemical_list: D008387:Marine Toxins; D009467:Neuromuscular Depolarizing Agents; D009498:Neurotoxins; C012301:domoic acid; D007608:Kainic Acid