title: Urine proteomics for acute kidney injury prognosis: another player and the long road ahead.
abstract: Urine represents a mine for proteomic markers of renal diseases, but its analysis is hindered by unresolved technical issues. Aregger et al. used an unbiased proteomics approach to analyze urine of critically ill patients. They discovered insulin-like growth factor-binding protein 7 (IGFBP-7) and linked it to acute kidney injury (AKI) outcome. Future efforts should address the biology of IGFBP-7 and related proteins to determine their role in AKI.
authors.affiliation: 1] Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada [2] Division of Nephrology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Ana
authors.initials: A
authors.lastname: Konvalinka
mesh_terms: D058186:Acute Kidney Injury / Q000652:urine*; D005260:Female; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000652:urine*; D008297:Male
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins; C102529:insulin-like growth factor binding protein-related protein 1