title: Selenium and selenoprotein function in brain disorders.
abstract: Selenoproteins are important for normal brain function, and decreased function of selenoproteins can lead to impaired cognitive function and neurological disorders. This review examines the possible roles of selenoproteins in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and epilepsy. Selenium deficiency is associated with cognitive decline, and selenoproteins may be helpful in preventing neurodegeneration in AD. PD is associated with impaired function of glutathione peroxidase selenoenzymes. In HD, selenium deters lipid peroxidation by increasing specific glutathione peroxidases. Selenium deficiency increases risk of seizures in epilepsy, whereas supplementation may help to alleviate seizures. Further studies on the mechanisms of selenoprotein function will increase our understanding of how selenium and selenoproteins can be used in treatment and prevention of brain disorders.
authors.affiliation: Department of Cell and Molecular Biology, University of Hawaii, John A. Burns School of Medicine, Honolulu, HI, USA.
authors.forename: Roshan
authors.initials: R
authors.lastname: Pillai
authors.forename: Jane H
authors.initials: JH
authors.lastname: Uyehara-Lock
authors.forename: Frederick P
authors.initials: FP
authors.lastname: Bellinger
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D012643:Selenium / Q000378:metabolism* / Q000627:therapeutic use; D051140:Selenoproteins / Q000378:metabolism*
chemical_list: D051140:Selenoproteins; D012643:Selenium
keywords: Alzheimer's disease; Huntington's disease; Parkinson's disease; epilepsy; glutathione; glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase; selenium; selenoprotein; thioredoxin reductase