title: Two novel lignans from Gaultheria yunnanensis.
abstract: Two new lignans, 9-salicyl-(+)-isolariciresinol (1) and gaultheroside G (2), together with seven known compounds, were isolated from the ethanolic extract of the whole plant of Gaultheria yunnanensis. Their structures were determined by extensive NMR and MS analyses. Gaultheroside G (2) was found to have an unusual ether linkage between the 2 and 9' positions of aryl-tetralin lignan skeleton. All nine compounds were assayed for inhibitory effects against nitric oxide and pro-inflammatory cytokines TNF-α and IL-6 release in LPS-induced RAW 246.7 macrophages, while no significant activities were observed for the evaluated compounds.
authors.affiliation: a Department of Phytochemistry , School of Pharmacy, Second Military Medical University , Shanghai 200433 , China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Gao
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Xi-Ke
authors.initials: XK
authors.lastname: Xu
authors.forename: Jun-Mian
authors.initials: JM
authors.lastname: Tian
authors.forename: Hua-Wu
authors.initials: HW
authors.lastname: Zeng
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Liu
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031282:Gaultheria / Q000737:chemistry*; D015850:Interleukin-6 / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D011498:Protein Precursors; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects; D000093242:Interleukin-6 Inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D017705:Lignans; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D011498:Protein Precursors; D014409:Tumor Necrosis Factor-alpha; D000093242:Interleukin-6 Inhibitors; C000591808:9-salicyl-isolariciresinol; C000591809:gaultheroside G; C061153:tumor necrosis factor precursor
keywords: Ericaceae; Gaultheria yunnanensis; anti-inflammatory activity; lignans