title: [Bronchioloalveolar carcinoma: an exceptional cause of diffuse lung disease in a patient with acute myeloid leukemia].
abstract: BACKGROUND
  Bronchiolo-alveolar carcinoma is a primary pulmonary adenocarcinoma developing in the terminal respiratory unit.
  
  
  METHODS
  An 84-year-old non-smoker woman with a history of untreated acute myeloid leukaemia was referred to the intensive care unit for pneumonia and acute respiratory failure. The patient reported dyspnoea and a productive cough for 3 months, treated by antibiotics and steroids without improvement. Thoracic CT-scan showed alveolar condensations and multiple nodular lesions. All microbiological samples were negative and the evolution was fatal within 72 hours despite empirical antibiotic therapy and noninvasive ventilation. Post-mortem lung biopsies gave a diagnosis of mucinous and non-mucinous bronchiolo-alveolar carcinoma with typical lepidic growth pattern of tumor cells and discrete septal thickening but no fibrosis, inflammation or local invasion.
  
  
  CONCLUSIONS
  Bronchiolo-alveolar carcinoma is an alternative diagnosis in alveolar condensations associated with pulmonary nodules even in a patient with immunosupression. Early diagnosis allows effective treatment in some cases.
authors.affiliation: Service des maladies respiratoires et réanimation respiratoire, université de Lorraine, hôpitaux de Brabois, CHU de Nancy, rue du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: A
authors.initials: A
authors.lastname: Boubaya
authors.affiliation: Service des maladies respiratoires et réanimation respiratoire, université de Lorraine, hôpitaux de Brabois, CHU de Nancy, rue du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: E
authors.initials: E
authors.lastname: Gomez
authors.affiliation: Service des maladies respiratoires et réanimation respiratoire, université de Lorraine, hôpitaux de Brabois, CHU de Nancy, rue du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: A
authors.initials: A
authors.lastname: Guerder
authors.affiliation: Service de radiologie, université de Lorraine, hôpitaux de Brabois, CHU de Nancy, rue du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: H
authors.initials: H
authors.lastname: Ropion-Michaux
authors.affiliation: Service des maladies respiratoires et réanimation respiratoire, université de Lorraine, hôpitaux de Brabois, CHU de Nancy, rue du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: A
authors.initials: A
authors.lastname: Kheir
authors.affiliation: Service d'anatomie et cytologie pathologiques, université de Lorraine, hôpital Central, CHU de Nancy, 54000 Nancy, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Vignaud
authors.affiliation: Service des maladies respiratoires et réanimation respiratoire, université de Lorraine, hôpitaux de Brabois, CHU de Nancy, rue du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: A
authors.initials: A
authors.lastname: Chaouat
authors.affiliation: Service des maladies respiratoires et réanimation respiratoire, université de Lorraine, hôpitaux de Brabois, CHU de Nancy, rue du Morvan, 54511 Vandœuvre-lès-Nancy, France. Electronic address: f.chabot@chu-nancy.fr.
authors.forename: F
authors.initials: F
authors.lastname: Chabot
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000175:diagnosis*; D000369:Aged, 80 and over; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008175:Lung Neoplasms / Q000175:diagnosis*; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*
keywords: Acute myeloid leukaemia; Acute respiratory failure; Bronchiolo-alveolar carcinoma; Carcinome bronchiolo-alvéolaire; Diffuse lung disease; Insuffisance respiratoire aiguë; Leucémie aiguë myéloïde; Pneumopathie diffuse