title: Scintigraphic Evaluation of Decontamination Lotion for Removal of Radioactive Contamination From Skin.
abstract: OBJECTIVE
  Skin contamination is one of the most likely risks after accidental or occupational radiological accidents. Using scintigraphy, we assessed a topical lotion for its decontamination efficacy (DE) after exposure with short-lived medical radioisotopes technetium Tc 99m (99mTc) and thallium 201Tl (201Tl).
  
  
  METHODS
  Using99mTc (300 ± 5 μCi/100 μl) and201Tl (100 ± 5 μCi/100 μl), the thoracoabdominal region (shaved skin) of Sprague Dawley rats and human tissue equivalent were contaminated and then decontaminated using cotton swabs soaked in formulated lotion at different time intervals. Static counts were recorded and calculated for DE. Histologic examination was performed on the animal model.
  
  
  RESULTS
  The DE of the formulation for99mTc and201Tl was 85% ± 5 and 88% ± 2, respectively. The prepared formulation effectively removed the radionuclides from the tissue surface.
  
  
  CONCLUSIONS
  The formulated lotion assisted in the effective removal of radiocontaminants by decontaminating the radionuclides. Moreover, minimal and easily manageable radioactive waste was generated by this process. Further investigation regarding the infusion of formulated lotion into ready-to-use skin wipes for self-decontamination may be useful for mass casualty scenarios. (Disaster Med Public Health Preparedness. 2014;0:-).
authors.affiliation: Division of Chemical, Biological, Radiological, and Nuclear Defence, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India.
authors.forename: Sudha
authors.initials: S
authors.lastname: Rana
authors.affiliation: Division of Chemical, Biological, Radiological, and Nuclear Medicine, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India.
authors.forename: Mita
authors.initials: M
authors.lastname: Dutta
authors.affiliation: Division of Chemical, Biological, Radiological, and Nuclear Defence, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India.
authors.forename: Navneet
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Division of Chemical, Biological, Radiological, and Nuclear Defence, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Goel
authors.affiliation: Department of Pharmaceutics, Jamia Hamdard University, New Delhi, India.
authors.forename: Abdul Wadood
authors.initials: AW
authors.lastname: Khan
authors.affiliation: Department of Pharmaceutics, Jamia Hamdard University, New Delhi, India.
authors.forename: Sabna
authors.initials: S
authors.lastname: Kotta
authors.affiliation: Department of Pharmaceutics, Jamia Hamdard University, New Delhi, India.
authors.forename: Javed
authors.initials: J
authors.lastname: Ali
authors.affiliation: Department of Pharmaceutics, Jamia Hamdard University, New Delhi, India.
authors.forename: Shahid Husain
authors.initials: SH
authors.lastname: Ansari
authors.affiliation: Department of Pharmaceutics and Medical Elementology and Toxicology, Jamia Hamdard University, New Delhi, India.
authors.forename: Sarwat
authors.initials: S
authors.lastname: Sultana
authors.affiliation: Division of Chemical, Biological, Radiological, and Nuclear Defence, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India.
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Sharma
keywords: decontamination; lotion; radionuclides; scintigraphy; skin