title: Molecular epidemiology of Mycobacterium tuberculosis strains circulating in the penitentiary system of Kazakhstan.
abstract: A total of 60 Mycobacterium tuberculosis isolates collected from patients in prisons in Kazakhstan and 125 from the civilian sector were examined using mycobacterial interspersed repetitive units-variable number of tandem repeat analysis in 2012. The proportion of tuberculosis strains with unique genotypes isolated from the civilian patients was 50.4%, while that in the prison patients was 31.7%. This difference was statistically significant (χ(2) 4.42, P 0.035), and may reflect a low genetic diversity of M. tuberculosis strains isolated from prison patients. The frequencies of mutations in the rpoB531 and katG315 genes of the M. tuberculosis strains isolated from the civilians and in the penitentiary system were not significantly different (rpoB531: 82.4% vs. 88.3%, and katG315: 98.4% vs. 100%, respectively).
authors.affiliation: National Center for Biotechnology, Astana, Kazakhstan.
authors.forename: A
authors.initials: A
authors.lastname: Ibrayeva
authors.affiliation: National Center for Biotechnology, Astana, Kazakhstan.
authors.forename: U
authors.initials: U
authors.lastname: Kozhamkulov
authors.affiliation: National Center for Biotechnology, Astana, Kazakhstan.
authors.forename: D
authors.initials: D
authors.lastname: Raiymbek
authors.affiliation: National Tuberculosis Centre, Almaty, Kazakhstan.
authors.forename: A
authors.initials: A
authors.lastname: Alenova
authors.affiliation: National Tuberculosis Centre, Almaty, Kazakhstan.
authors.forename: S
authors.initials: S
authors.lastname: Igilikova
authors.affiliation: National Center for Biotechnology, Astana, Kazakhstan.
authors.forename: E
authors.initials: E
authors.lastname: Zholdybayeva
authors.affiliation: National Tuberculosis Centre, Almaty, Kazakhstan.
authors.forename: T
authors.initials: T
authors.lastname: Abildaev
authors.affiliation: National Center for Biotechnology, Astana, Kazakhstan.
authors.forename: K
authors.initials: K
authors.lastname: Momynaliev
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D015373:Bacterial Typing Techniques; D016009:Chi-Square Distribution; D016000:Cluster Analysis; D004269:DNA, Bacterial / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005838:Genotype; D006801:Humans; D007623:Kazakhstan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics*; D010641:Phenotype; D011237:Predictive Value of Tests; D011329:Prisoners; D011330:Prisons; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D004269:DNA, Bacterial