title: Acceleration of Bone Regeneration by BMP-2-Loaded Collagenated Biphasic Calcium Phosphate in Rabbit Sinus.
abstract: OBJECTIVE
  The objective of this study was to determine the effectiveness of collagenated biphasic calcium phosphate (CBCP) as a carrier for bone morphogenetic protein-2 (BMP-2) at the early stage of healing in rabbit sinus.
  
  
  METHODS
  In 16 rabbits, BMP-2-loaded CBCP was grafted into one sinus (the BMP group) and saline-soaked CBCP was grafted into another sinus (the CTL group). The groups were assigned randomly. After 2 weeks (n = 8) or 4 weeks (n = 8), radiographic and histological analysis was performed.
  
  
  RESULTS
  Total augmented volume was significantly larger in the BMP group at both healing periods. Furthermore, new bone volume was significantly greater in the BMP group at 4 weeks. Marked bone formation near the schneiderian membrane was found in the BMP groups at the early healing period. At 4 weeks, evenly distributed new bone was observed in the BMP group, whereas the new bone was sparsely distributed in the central portion in the CTL group.
  
  
  CONCLUSIONS
  It can be concluded that the addition of BMP-2 to CBCP resulted in a greater initial augmented volume as a result of postoperative swelling, which is replaced by early bone formation, and it was prominent near the Schneiderian membrane.
authors.affiliation: Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Jung-Soo
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Jae-Kook
authors.initials: JK
authors.lastname: Cha
authors.affiliation: Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Ah-Ran
authors.initials: AR
authors.lastname: Cho
authors.affiliation: Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Jung-Seok
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Periodontology, School of Dentistry, Kyung Hee University, Seoul, South Korea.
authors.forename: Ji-Youn
authors.initials: JY
authors.lastname: Hong
authors.affiliation: Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Ui-Won
authors.initials: UW
authors.lastname: Jung
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology*; D006882:Hydroxyapatites / Q000494:pharmacology*; D021621:Imaging, Three-Dimensional; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects; D011817:Rabbits; D011897:Random Allocation; D059546:Sinus Floor Augmentation / Q000379:methods*; D013524:Surgical Flaps; D014945:Wound Healing / Q000502:physiology; D055114:X-Ray Microtomography
chemical_list: D019485:Bone Morphogenetic Proteins; D006882:Hydroxyapatites; C074950:hydroxyapatite-beta tricalcium phosphate; D003094:Collagen
keywords: bone regeneration; bone substitutes; bone tissue engineering; sinus augmentation