title: Influence of aerobic training and detraining on serum BDNF, insulin resistance, and metabolic risk factors in middle-aged men diagnosed with metabolic syndrome.
abstract: OBJECTIVE
  To study the influence of aerobic exercise training on brain-derived neurotrophic factor (BDNF), insulin resistance, and lipid profile in middle-aged men diagnosed with metabolic syndrome (MetS).
  
  
  METHODS
  This is an experimental repeated measure study.
  
  
  METHODS
  Subjects participated in aerobic training programs (18 sessions of 25-40 minutes per session) in Guilan University gymnasium and court.
  
  
  METHODS
  A total of 21 middle-aged men (50-65 years old) diagnosed with MetS participated.
  
  
  METHODS
  We randomly divided 21 middle-aged men with MetS into exercise and control groups. The exercise group followed an aerobic training program (18 sessions, 3/wk) at 50% to 60% of V[Combining Dot Above]O2 peak (25-40 minutes per session) and 6 weeks of detraining. Blood samples were collected at baseline, end of the training, and detraining.
  
  
  METHODS
  High BDNF level in patients with MetS and its reduction after chronic aerobic exercise.
  
  
  RESULTS
  Aerobic training significantly decreased all the metabolic risk factors, including overall MetS z score, insulin resistance, and lipid profile (P < 0.05). After the detraining period, plasma triglyceride, high-density lipoprotein, and also overall MetS z score remained unchanged (P < 0.05); however, serum BDNF, which was decreased by aerobic training (P = 0.013), restored to the baseline at the end of the detraining (P = 0.018).
  
  
  CONCLUSIONS
  Improved metabolic risk factors along with decreased serum BDNF in response to aerobic training and the opposite direction during the detraining emphasize the importance of physical activity in the treatment of MetS and prevention of related diseases.
authors.affiliation: *Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran; †Cellular and Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran; ‡Department of Physical Education and Sport Sciences, Faculty of Psychology and Education, Azarbaijan Shahid Madani University, Tabriz, Iran; and §Department of Physiology, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Arsalan
authors.initials: A
authors.lastname: Damirchi
authors.forename: Bahram Soltani
authors.initials: BS
authors.lastname: Tehrani
authors.forename: Karim Azali
authors.initials: KA
authors.lastname: Alamdari
authors.forename: Parvin
authors.initials: P
authors.lastname: Babaei
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology / Q000628:therapy*; D008875:Middle Aged; D012307:Risk Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D008076:Cholesterol, HDL; D014280:Triglycerides; C579455:BDNF protein, human