title: Marsupellins A-F, ent-longipinane-type sesquiterpenoids from the Chinese liverwort Marsupella alpine with acetylcholinesterase inhibitory activity.
abstract: Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of the Chinese liverwort Marsupella alpine afforded six new [marsupellins A-F (1-6)] and three known (7-9) ent-longipinane-type sesquiterpenoids. The structures were determined from MS and NMR spectroscopic data, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compounds 1-9 exhibited moderate to weak AChE inhibitory activity.
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University , Jinan 250012, People's Republic of China.
authors.forename: Jiaozhen
authors.initials: J
authors.lastname: Zhang
authors.forename: Peihong
authors.initials: P
authors.lastname: Fan
authors.forename: Rongxiu
authors.initials: R
authors.lastname: Zhu
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Li
authors.forename: Zhaomin
authors.initials: Z
authors.lastname: Lin
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.forename: Chunmei
authors.initials: C
authors.lastname: Zhang
authors.forename: Jinchuan
authors.initials: J
authors.lastname: Zhou
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Lou
mesh_terms: D000465:Algorithms; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D035926:Hepatophyta / Q000737:chemistry*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes