title: Nesfatin-1 correlates with hypertension in overweight or obese Han Chinese population.
abstract: We investigated blood nesfatin-1 levels in hypertension patients. We found that fasting plasma nesfatin-1 levels were significantly higher in hypertension patients than in control groups, especially in overweight/obese hypertension patients (4.5 ± 2.1 versus 3.3 ± 1.1 ng/ml, p < 0.01). Body mass index, systolic blood pressure and diastolic blood pressure were indeed positively correlated with fasting plasma nesfatin-1 levels (r = 0.234, p < 0.05; r = 0.304, p < 0.01; r = 0.251, p < 0.05; r = 0.461, p < 0.01; respectively). Logistic regression analysis revealed that the plasma level of nesfatin-1 could be independent of risk prediction over standard measures (OR = 1.547, 95% CI: 1.153-6.273, p = 0.026). Nesfatin-1 has the incremental contribution to hypertension risk prediction (IDI: 0.014, p = 0.018; NRI: 0.050, p = 0.043). The plasma nesfatin-1 level in hypertension patients with microalbuminuria are significantly higher than those without microalbuminuria patients (6.4 ± 2.1 ng/ml versus 3.9 ± 1.8 ng/ml, p < 0.01). Nesfatin-1 might play an important role in obesity hypertension, and its increase could be a risk factor for obesity-associated hypertension.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University , Zhengzhou , China and.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Ma
authors.forename: Qingzhu
authors.initials: Q
authors.lastname: Wang
authors.forename: Yingni
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lina
authors.initials: L
authors.lastname: Wu
authors.forename: Hongfei
authors.initials: H
authors.lastname: Ji
authors.forename: Guijun
authors.initials: G
authors.lastname: Qin
authors.forename: Jieli
authors.initials: J
authors.lastname: Lu
authors.forename: Yufang
authors.initials: Y
authors.lastname: Bi
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002135:Calcium-Binding Proteins / Q000097:blood*; D004268:DNA-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D050177:Overweight / Q000097:blood*; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins
keywords: Body mass index; Han Chinese; hypertension; nesfatin-1; obesity