title: Fecal microbiota transplantation inducing remission in Crohn's colitis and the associated changes in fecal microbial profile.
abstract: Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the intestine of unclear etiology. Increasing evidence has pointed to intestinal dysbiosis as a potential factor in a genetically susceptible individual. Fecal microbiota transplantation (FMT) has been used to treat inflammatory bowel disease with variable degrees of success. Herein, we report a patient with Crohn's colitis, previously failing an immunosuppressant, who achieved clinical, endoscopic, and histologic remission after a single fecal microbiota transplantation infusion. We have further characterized the changes in the fecal microbiota associated with this observation.
authors.affiliation: *Department of Medicine, University of Alberta, Edmonton, AB †Department of Environmental Science and Policy, George Mason University, Manassa, VA.
authors.forename: Dina
authors.initials: D
authors.lastname: Kao
authors.forename: Naomi
authors.initials: N
authors.lastname: Hotte
authors.forename: Patrick
authors.initials: P
authors.lastname: Gillevet
authors.forename: Karen
authors.initials: K
authors.lastname: Madsen
mesh_terms: D000328:Adult; D001691:Biological Therapy / Q000379:methods*; D003424:Crohn Disease / Q000382:microbiology* / Q000628:therapy*; D005243:Feces / Q000382:microbiology*; D006801:Humans; D008297:Male; D064307:Microbiota; D012336:RNA, Ribosomal, 16S / Q000032:analysis; D012074:Remission Induction
chemical_list: D012336:RNA, Ribosomal, 16S