title: Mononeuritis multiplex: association with infectious condition and familial background in a tropical environment: a case report.
abstract: Mononeuritis multiplex is characterized by an asymmetric pattern with affection of the peripheral nervous system; this form of polyneuropathy is often seen in non-systemic vasculitis. We present a case of multiplex neuropathy in a patient with histologicaly verified Hailey-Hailey disease. With the exception of this comorbidity--in its characteristic form presenting additionally with a superinfected subdermal node--we did not find any other possible etiologic factor possibly causative of multiplex neuritis. The diagnosis was confirmed by electrophysiological testing. To our knowledge, this is the first case report indicating a possible relationship between Hailey-Hailey disease and multiplex neuritis. There exists only one related study in the literature, which was conducted in Columbia--our patient's home country. This study delineates a clinically similar dermal disease (pemphigus foliaceus) in patients from rural Colombia (El Bagre). The authors detected anti-neuronal antibodies which were interpreted to be responsible for the pathognomonic burning sensations.
authors.affiliation: Department of Neurology, Wagner Jauregg Hospital, Wagner Jauregg Weg 15, 4021, Linz, Austria, klaus.boeck@gespag.at.
authors.forename: Klaus
authors.initials: K
authors.lastname: Böck
authors.forename: Carmen
authors.initials: C
authors.lastname: Pschaid
authors.forename: Raffi
authors.initials: R
authors.lastname: Topakian
authors.forename: Karl
authors.initials: K
authors.lastname: Stieglbauer
authors.forename: Stefan
authors.initials: S
authors.lastname: Doppler
authors.forename: Joachim Tim
authors.initials: JT
authors.lastname: von Oertzen
authors.forename: Robert
authors.initials: R
authors.lastname: Pichler
mesh_terms: D000328:Adult; D000700:Analgesics / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001317:Austria; D003105:Colombia; D006801:Humans; D008297:Male; D020422:Mononeuropathies / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D016506:Pemphigus, Benign Familial / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D016896:Treatment Outcome; D014329:Tropical Climate
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents