title: Mechanical performance of a biocompatible biocide soda-lime glass-ceramic.
abstract: A biocompatible soda-lime glass-ceramic in the SiO2-Na2O-Al2O3-CaO-B2O3 system containing combeite and nepheline as crystalline phases, has been obtained at 750°C by two different routes: (i) pressureless sintering and (ii) Spark Plasma Sintering. The SPS glass-ceramic showed a bending strength, Weibull modulus, and toughness similar values to the cortical human bone. This material had a fatigue limit slightly superior to cortical bone and at least two times higher than commercial dental glass-ceramics and dentine. The in vitro studies indicate that soda-lime glass-ceramic is fully biocompatible. The in vivo studies in beagle jaws showed that implanted SPS rods presented no inflammatory changes in soft tissues surrounding implants in any of the 10 different cases after four months implantation. The radiological analysis indicates no signs of osseointegration lack around implants. Moreover, the biocide activity of SPS glass-ceramic versus Escherichia coli, was found to be >4log indicating that it prevents implant infections. Because of this, the SPS new glass-ceramic is particularly promising for dental applications (inlay, crowns, etc).
authors.affiliation: Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas (CSIC), Cantoblanco, 28049 Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: López-Esteban
authors.affiliation: Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas (CSIC), Cantoblanco, 28049 Madrid, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Bartolomé
authors.affiliation: Centro de Investigación en Nanomateriales y Nanotecnología (CINN), [Consejo Superior de Investigaciones Científicas-Universidad de Oviedo-Principado de Asturias], Parque Tecnológico de Asturias, 33428 Llanera, Spain.
authors.forename: L A
authors.initials: LA
authors.lastname: Dí Az
authors.affiliation: Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas (CSIC), Cantoblanco, 28049 Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Esteban-Tejeda
authors.affiliation: Centro de Investigación en Nanomateriales y Nanotecnología (CINN), [Consejo Superior de Investigaciones Científicas-Universidad de Oviedo-Principado de Asturias], Parque Tecnológico de Asturias, 33428 Llanera, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Prado
authors.affiliation: Centro de Investigación en Nanomateriales y Nanotecnología (CINN), [Consejo Superior de Investigaciones Científicas-Universidad de Oviedo-Principado de Asturias], Parque Tecnológico de Asturias, 33428 Llanera, Spain.
authors.forename: R
authors.initials: R
authors.lastname: López-Piriz
authors.affiliation: Centro de Investigación en Nanomateriales y Nanotecnología (CINN), [Consejo Superior de Investigaciones Científicas-Universidad de Oviedo-Principado de Asturias], Parque Tecnológico de Asturias, 33428 Llanera, Spain; Moscow State University of Technology STANKIN, Vadkovskij per. 1, Moscow Oblast, Moscow, Russian Federation.
authors.forename: R
authors.initials: R
authors.lastname: Torrecillas
authors.affiliation: Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas (CSIC), Cantoblanco, 28049 Madrid, Spain. Electronic address: jsmoya@icmm.csic.es.
authors.forename: J S
authors.initials: JS
authors.lastname: Moya
mesh_terms: D000818:Animals; D017610:Calcium Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D002516:Ceramics / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D004202:Disinfectants / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D004285:Dogs; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008422:Materials Testing; D055595:Mechanical Phenomena; D008903:Minerals / Q000737:chemistry; D010087:Oxides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D012463:Saliva / Q000378:metabolism; D012972:Sodium Hydroxide / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D017610:Calcium Compounds; D020099:Coated Materials, Biocompatible; D004202:Disinfectants; D008903:Minerals; D010087:Oxides; C004569:soda lime; D012972:Sodium Hydroxide; C023506:Glass ceramics
keywords: Biocide; Dental applications; Glass-ceramic; Mechanical properties; SPS