title: Serial optical frequency domain imaging in STEMI patients: the follow-up report of TROFI study.
abstract: OBJECTIVE
  To investigate the incidence of incomplete stent apposition and to explore the impact of the presence of thrombus and protruding plaque after stent implantation on neointima formation at follow-up in ST-segment elevation myocardial infarction (STEMI) patients with serial optical frequency domain imaging (OFDI) investigations.
  
  
  RESULTS
  In a multi-centre study, 141 patients with ST elevation myocardial infarction <12 h from onset were randomized to either PPCI with thrombectomy (TB) using an Eliminate catheter (TB: n = 71) or without TB (non-TB: n = 70). OFDI after drug-eluting stenting was performed using TERUMO OFDI system. Per protocol, at follow-up 49 patients segments were reimaged. At post-procedure and follow-up, there were no differences in stent and lumen areas between the two groups. At follow-up, per strut-level analysis, percentage of incompletely apposed struts was 0.42 ± 0.94 vs. 0.38 ± 0.77% (P = 0.76), and percentage of covered struts was 92.7 ± 7.2 vs. 94.4 ± 9.2% (P = 0.47) in the TB and non-TB groups, respectively. There was a positive correlation between intra-stent structure (ISS) volume at post-procedure and the neointima volume at 6-month follow-up (Pearson's r = 0.409, P = 0.04). Up to 12 months, there have been two and four patients having target vessel failure in the TB and in the non-TB groups, respectively.
  
  
  CONCLUSIONS
  In patients with STEMI, there were no significant differences in OFDI parameters between TB and non-TB groups at both post-procedure and 6-month follow-up. However, ISS volume at post-procedure was positively associated with neointimal volume at 6-month follow-up.
authors.affiliation: Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands Cardialysis B.V., Rotterdam, The Netherlands hect2701@gmail.com hgarcia@cardialysis.nl hect2701@yahoo.es.
authors.forename: Hector M
authors.initials: HM
authors.lastname: García-García
authors.affiliation: Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors.forename: Takashi
authors.initials: T
authors.lastname: Muramatsu
authors.affiliation: Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands Cardialysis B.V., Rotterdam, The Netherlands Aarhus University Hospital, Skejby 8200, Denmark Maasstad ziekenhuis, Rotterdam 3079 DZ, The Netherland Terumo Europe, Leuven, Belgium.
authors.forename: Shimpei
authors.initials: S
authors.lastname: Nakatani
authors.affiliation: Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors.forename: Il Soo
authors.initials: IS
authors.lastname: Lee
authors.affiliation: Aarhus University Hospital, Skejby 8200, Denmark.
authors.forename: Niels Ramsing
authors.initials: NR
authors.lastname: Holm
authors.affiliation: Aarhus University Hospital, Skejby 8200, Denmark.
authors.forename: Leif
authors.initials: L
authors.lastname: Thuesen
authors.affiliation: Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors.forename: Robert-Jan
authors.initials: RJ
authors.lastname: van Geuns
authors.affiliation: Maasstad ziekenhuis, Rotterdam 3079 DZ, The Netherland.
authors.forename: Martin
authors.initials: M
authors.lastname: van der Ent
authors.affiliation: Terumo Europe, Leuven, Belgium.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Borovicanin
authors.affiliation: Terumo Europe, Leuven, Belgium.
authors.forename: Dragica
authors.initials: D
authors.lastname: Paunovic
authors.affiliation: Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Onuma
authors.affiliation: Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D006328:Cardiac Catheterization; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods; D054855:Drug-Eluting Stents; D005060:Europe; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000628:therapy*; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D011857:Radiographic Image Interpretation, Computer-Assisted; D016037:Single-Blind Method; D017131:Thrombectomy; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media
keywords: acute myocardial infarction; coronary artery disease; coronary thrombosis; optical coherence tomography; prolapse