title: Understanding tissue context influences on intratumour heterogeneity.
abstract: Although human cancers exhibit intratumour heterogeneity, the influence of the tumour environment on this property is unclear. Single basal-like mammary epithelial cells are now shown to engage a dynamic TGFBR3-JUND signalling circuit in an extracellular-matrix-dependent manner. Cell transition between the distinct gene expression states underlying this circuit alters their properties and may modulate their propensity to malignancy.
authors.affiliation: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02215, USA.
authors.forename: Franziska
authors.initials: F
authors.lastname: Michor
authors.affiliation: Center for Bioengineering and Tissue Regeneration and Departments of Surgery, Anatomy, Bioengineering and Therapeutics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Helen Diller Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA.
authors.forename: Valerie M
authors.initials: VM
authors.lastname: Weaver
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism*; D005260:Female; D006801:Humans; D053555:Keratin-5 / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: C559371:JunD protein, human; C503940:KRT5 protein, human; D053555:Keratin-5; D011509:Proteoglycans; D016755:Proto-Oncogene Proteins c-jun; D018125:Receptors, Transforming Growth Factor beta; C071736:betaglycan