title: Complexation of alkyl groups and ghrelin in a deep, water-soluble cavitand.
abstract: A cavitand with ionic, but nonionizable "feet" folds around hydrophobic guests in D2O. Short alkanes and ibuprofen are included and exchange rates are slow on the NMR timescale. Normal octanoyl groups show good affinity for the cavitand and the gastric peptide ghrelin is bound at low pH and physiological temperature.
authors.affiliation: Skaggs Institute for Chemical Biology, The Scripps Research Institute, and Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. jrebek@scripps.edu.
authors.forename: Kang-Da
authors.initials: KD
authors.lastname: Zhang
authors.forename: Dariush
authors.initials: D
authors.lastname: Ajami
authors.forename: Jesse V
authors.initials: JV
authors.lastname: Gavette
authors.forename: Julius
authors.initials: J
authors.lastname: Rebek
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D017666:Deuterium Oxide / Q000737:chemistry; D004988:Ethers, Cyclic / Q000737:chemistry* / Q000378:metabolism; D054439:Ghrelin / Q000737:chemistry* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007052:Ibuprofen / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011485:Protein Binding; D012118:Resorcinols / Q000737:chemistry* / Q000378:metabolism; D012995:Solubility; D013696:Temperature; D014867:Water / Q000737:chemistry*
chemical_list: D000473:Alkanes; D004988:Ethers, Cyclic; D054439:Ghrelin; D012118:Resorcinols; C442939:cavitand; D014867:Water; D017666:Deuterium Oxide; D007052:Ibuprofen