title: Pulmonary and retroperitoneal lesions induced by methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis.
abstract: A 78-year-old man had fatigue and appetite loss for 5 months. He had been receiving low-dose methotrexate for rheumatoid arthritis. Computed tomography revealed multiple pulmonary infiltrations and muddiness of the fatty tissue surrounding the right kidney, ureter wall thickening, and hydroureter/nephrosis, which were suspected retroperitoneal fibrosis. Lung biopsy revealed polymorphic/lymphoplasmacytic lymphoproliferative disorder. Methotrexate withdrawal resulted in spontaneous regression. Therefore, retroperitoneal lesion may account for the diagnosis as having retroperitoneal lymphoproliferative disorder, not retroperitoneal fibrosis.
authors.affiliation: a Department of Respiratory Medicine , Jikei University School of Medicine, Kashiwa Hospital , Chiba , Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yamakawa
authors.affiliation: a Department of Respiratory Medicine , Jikei University School of Medicine, Kashiwa Hospital , Chiba , Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshida
authors.affiliation: b Department of Diagnostic Pathology , Jikei University School of Medicine, Kashiwa Hospital , Chiba , Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Katagi
authors.affiliation: b Department of Diagnostic Pathology , Jikei University School of Medicine, Kashiwa Hospital , Chiba , Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Hirooka
authors.affiliation: a Department of Respiratory Medicine , Jikei University School of Medicine, Kashiwa Hospital , Chiba , Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Okuda
authors.affiliation: a Department of Respiratory Medicine , Jikei University School of Medicine, Kashiwa Hospital , Chiba , Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Ishikawa
authors.affiliation: a Department of Respiratory Medicine , Jikei University School of Medicine, Kashiwa Hospital , Chiba , Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Takagi
authors.affiliation: c Division of Respiratory Diseases, Department of Internal Medicine , Jikei University School of Medicine , Tokyo , Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kuwano
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D001706:Biopsy; D006801:Humans; D008168:Lung / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D012185:Retroperitoneal Fibrosis / Q000139:chemically induced* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate
keywords: Lymphoproliferative disorder; Methotrexate; Retroperitoneal fibrosis