title: Steroidal aglycones from stems of Marsdenia tenacissima that inhibited the hedgehog signaling pathway.
abstract: Two novel steroidal aglycones, together with four known ones, were isolated from the hydrolysis extract of the CHCl3 soluble extract of the stems of Marsdenia tenacissima. Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods, including 1D and 2D NMR spectroscopy. These compounds displayed inhibition of the Hedgehog signaling pathway in vitro.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Feng-Yang
authors.initials: FY
authors.lastname: Chen
authors.forename: Shi-Fang
authors.initials: SF
authors.lastname: Xu
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Ye
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Li
mesh_terms: D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors*; D031101:Marsdenia / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis; D018547:Plant Stems / Q000737:chemistry; D015398:Signal Transduction / Q000187:drug effects*; D013256:Steroids / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D053823:Hedgehog Proteins; D010936:Plant Extracts; D013256:Steroids