title: Secreted frizzled-related protein 4 (SFRP4) and fractalkine (CX3CL1) - Potential new biomarkers for β-cell dysfunction and diabetes.
abstract: The discovery of new risk factors for diabetes is a major challenge for contemporary science. Pathogenesis of type 2 diabetes mellitus (T2DM) is closely related to adipose tissue dysfunction. The aim of this review was to describe recently discovered cytokines: fractalkine (CX3CL1, FKN) and secreted frizzled-related protein 4 (SFRP4) as potential biomarkers of early β cell dysfunction and diabetes. The association of CX3CL1 and SFRP4 with low-grade inflammation in adipose tissue links obesity with disturbances in insulin secretion and impaired glucose metabolism, therefore it indicates new therapeutic and preventive targets in both healthy and diabetic subjects.
authors.affiliation: Department of Laboratory Medicine, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, Poland. Electronic address: bergmann@vp.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Bergmann
authors.affiliation: Department of Laboratory Medicine, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, Poland.
authors.forename: Grazyna
authors.initials: G
authors.lastname: Sypniewska
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D054428:Chemokine CX3CL1 / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D015415:Biomarkers; D054428:Chemokine CX3CL1; D011518:Proto-Oncogene Proteins; C118723:SFRP4 protein, human; D000094742:Secreted Frizzled-Related Proteins
keywords: Adipocytokines; Diabetes; Fractalkine; Insulin resistance; Secreted frizzled-related protein 4