title: Distal cholangiocarcinoma.
abstract: Cholangiocarcinoma involving the distal common bile duct (distal cholangiocarcinoma [DCC]) is a periampullary neoplasm that is less common than, but often difficult to distinguish from, pancreatic adenocarcinoma (PDA). The prognosis and cure rate of DCC is improved over that of PDA, but it remains a highly lethal disease. Although the diagnostic and therapeutic management of DCC is not dissimilar from PDA, the pathophysiology is, in many instances, distinctly different. A multi-disciplinary approach toward DCC is important.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Tennessee Health Science Center, 910 Madison Avenue, Suite 329, Memphis, TN 38163, USA.
authors.forename: Paxton V
authors.initials: PV
authors.lastname: Dickson
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Tennessee Health Science Center, 910 Madison Avenue, Suite 329, Memphis, TN 38163, USA. Electronic address: sbehrman@uthsc.edu.
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Behrman
mesh_terms: D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000601:surgery*; D015209:Cholangitis, Sclerosing / Q000175:diagnosis; D015529:Choledochal Cyst / Q000175:diagnosis; D055088:Early Detection of Cancer; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008109:Liver Diseases, Parasitic / Q000175:diagnosis; D009154:Mutation / Q000235:genetics; D010166:Palliative Care / Q000379:methods; D011230:Precancerous Conditions / Q000175:diagnosis; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
keywords: Adjuvant therapy; Cholangiocarcinoma; Pathophysiology; Surgery