title: Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses.
abstract: Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1β and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.
authors.affiliation: Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, 74078.
authors.forename: Brian
authors.initials: B
authors.lastname: Krumm
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiang
authors.forename: Junpeng
authors.initials: J
authors.lastname: Deng
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000276:immunology; D053590:Interleukin 1 Receptor Antagonist Protein / Q000737:chemistry / Q000276:immunology; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000276:immunology*; D020382:Interleukin-18 / Q000737:chemistry / Q000276:immunology; D008958:Models, Molecular; D011487:Protein Conformation; D015398:Signal Transduction
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D020382:Interleukin-18; C118370:interleukin-18 binding protein
keywords: agonist; antagonist; cytokine; inflammation; interleukin; receptors