title: Synthesis of quinoxaline azido and amino reverse ribofuranoside and their O-regioisomers.
abstract: A series of quinoxaline azido reverse nucleosides 3a-c and their O-regioisomers 4a-c was prepared by reaction of quinoxaline 1a-c with 3-azido-3-deoxy-1,2-O-isopropylidene-5-p-toluenesulfonyl-D-ribofuranose (2) in the presence of sodium hydride. Structure modification of these interesting structures includes reduction and the subsequent acetylation reactions to give quinoxaline amino and acetyl amino reverse nucleosides and their O-regioisomers.
authors.affiliation: a Department of Chemistry, Faculty of Science , Suez Canal University , Ismailia , Egypt.
authors.forename: Ibrahim A I
authors.initials: IA
authors.lastname: Ali
mesh_terms: D000107:Acetylation; D001386:Azides / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry; D017670:Sodium Compounds
chemical_list: D001386:Azides; D004791:Enzyme Inhibitors; D009705:Nucleosides; D011810:Quinoxalines; D017670:Sodium Compounds; C524957:sodium hydride