title: Anti-fatigue and vasoprotective effects of quercetin-3-O-gentiobiose on oxidative stress and vascular endothelial dysfunction induced by endurance swimming in rats.
abstract: Chronic fatigue accumulation increases the incidence of cardiovascular disease while the treatment of antioxidants could prevent this development. We have previously shown that quercetin-3-O-gentiobiose (QG), a flavonoid isolated from tonic herb Okra, possesses anti-oxidative properties. In the present study, the protective effects of QG were evaluated in a rat model of load-induced endurance swimming. Oral administration of QG at the doses of 25-75mg/kg could significantly improve the endurance capability of rats to fatigue along with decrease serum lactic acid and blood urea nitrogen levels were decreased. Moreover, QG could alleviate vascular impairments, enhance the activities of antioxidant enzymes and attenuate the levels of inflammatory cytokines (MCP-1, IL-6 and TNF-α). The results indicated that QG had anti-fatigue and vasoprotective effects and represented a potential agent for the treatment of aortic pathology involved with fatigue- and related syndrome.
authors.affiliation: The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, Lin'an 311300, China; School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Lin
authors.affiliation: The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, Lin'an 311300, China.
authors.forename: Hua-Liang
authors.initials: HL
authors.lastname: Liu
authors.affiliation: Zhejiang Academy of Medical Sciences, Hangzhou 310013, China; Zhejiang Chinese Medical University, Hangzhou 310053, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Fang
authors.affiliation: Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Chen-Huan
authors.initials: CH
authors.lastname: Yu
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou 310053, China.
authors.forename: Yao-Kang
authors.initials: YK
authors.lastname: Xiong
authors.affiliation: The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, Lin'an 311300, China. Electronic address: yuan_ke001@126.com.
authors.forename: Ke
authors.initials: K
authors.lastname: Yuan
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D018932:Chemokine CCL2 / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000473:pathology*; D005221:Fatigue / Q000188:drug therapy*; D006027:Glycosides / Q000494:pharmacology*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010805:Physical Conditioning, Animal; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014652:Vascular Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology
chemical_list: D000975:Antioxidants; C491766:Ccl2 protein, rat; D018932:Chemokine CCL2; D006027:Glycosides; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; C088177:quercetin 3-O-gentobioside; D011794:Quercetin
keywords: Antioxidant; Fatigue; Flavonoid; Oxidative stress; Vascular endothelial dysfunction