title: HSV-1 biology and life cycle.
abstract: Herpes simplex virus type 1 (HSV-1) is a common and important human pathogen that has been studied in a wide variety of contexts for several decades. This book presents chapters on protocols on many strands of HSV-1 research that are currently in use in leading laboratories. This chapter gives a brief overview of HSV-1 biology and life cycle, covering basic aspects of the virus and its replication in cultured cells, the diseases caused by the virus, viral latency, antiviral defenses, and the mechanisms that the virus uses to counteract these defenses.
authors.affiliation: MRC-University of Glasgow Centre for Virus Research, 8 Church Street, Glasgow, G11 5JR, Scotland UK, roger.everett@glasgow.ac.uk.
authors.forename: Roger D
authors.initials: RD
authors.lastname: Everett
mesh_terms: D002460:Cell Line; D018259:Herpesvirus 1, Human / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity; D006801:Humans; D008018:Life Cycle Stages; D008967:Molecular Biology / Q000379:methods*; D017735:Virus Latency; D014779:Virus Replication / Q000235:genetics*