title: Protective effects of equimolar mixtures of monomer and dimer of dehydrozingerone with α-tocopherol and/or ascorbyl palmitate during bulk lipid autoxidation.
abstract: Protective effects of recently synthesised dehydrozingerone, M1OH (which is one half of the molecule of curcumin) and dimer of dehydrozingerone, D1(OH)2, as individual compounds (1 mM) and as equimolar binary (1:1) and ternary (1:1:1) mixtures with α-tocopherol (TOH) and/or ascorbyl palmitate (AscPH), were studied during bulk lipid autoxidation at 80 °C. The highest oxidation stability of lipid substrate, in the presence of individual compounds, was found for TOH, followed by D1(OH)2 and M1OH, determined from the main kinetic parameters (antioxidant efficiency, reactivity and capacity). AscPH did not show any protective effect. Synergism was obtained for the binary mixtures of (TOH+AscPH) [42.4%], (M1OH+TOH) [32.4%] and (M1OH+AscPH) [35.6%] and for the ternary mixture of (M1OH+TOH+AscPH) [28.7%]. Different protective effects observed were explained on the basis (of results) of TOH regeneration and its content determined by HPLC. These antioxidant binary and ternary mixtures can be used as functional components of foods with health-promoting effects.
authors.affiliation: Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, bl. 9, Sofia 1113, Bulgaria. Electronic address: vedeka@abv.bg.
authors.forename: Vessela
authors.initials: V
authors.lastname: Kancheva
authors.affiliation: Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, bl. 9, Sofia 1113, Bulgaria.
authors.forename: Adriana
authors.initials: A
authors.lastname: Slavova-Kazakova
authors.affiliation: CNR Istituto di Chimica Biomolecolare di Sassari, Traversa La Crucca 3, I-07100 Sassari-Baldinca, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Fabbri
authors.affiliation: CNR Istituto di Chimica Biomolecolare di Sassari, Traversa La Crucca 3, I-07100 Sassari-Baldinca, Italy.
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Dettori
authors.affiliation: CNR Istituto di Chimica Biomolecolare di Sassari, Traversa La Crucca 3, I-07100 Sassari-Baldinca, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Delogu
authors.affiliation: Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwina Street 10, 10-748 Olsztyn, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Janiak
authors.affiliation: Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwina Street 10, 10-748 Olsztyn, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Amarowicz
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013343:Styrenes / Q000737:chemistry*; D024502:alpha-Tocopherol / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D008055:Lipids; D013343:Styrenes; C052933:methyl-3-methoxy-4-hydroxystyryl ketone; D024502:alpha-Tocopherol; D003474:Curcumin; D001205:Ascorbic Acid; C031226:6-O-palmitoylascorbic acid
keywords: Ascorbyl palmitate; Bulk lipid autoxidation; Dehydrozingerone; Dimer of dehydrozingerone; Protective effect; α-Tocopherol