title: Coming full circle-from endless complexity to simplicity and back again.
abstract: Cell has celebrated the powers of reductionist molecular biology and its major successes for four decades. Those who have participated in cancer research during this period have witnessed wild fluctuations from times where endless inexplicable phenomenology reigned supreme to periods of reductionist triumphalism and, in recent years, to a move back to confronting the endless complexity of this disease.
authors.affiliation: Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Ludwig/MIT Center for Molecular Oncology, Cambridge, MA 02142, USA; MIT Department of Biology, Cambridge, MA 02142, USA. Electronic address: weinberg@wi.mit.edu.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Weinberg
mesh_terms: D000818:Animals; D023281:Genomics; D006801:Humans; D008967:Molecular Biology; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D009857:Oncogenes; D012190:Retroviridae / Q000502:physiology