title: Syntheses of new tuberculosis inhibitors promoted by microwave irradiation.
abstract: Tuberculosis (TB) represents a major public health problem. The growing number of (extensively) multi-drug resistance cases indicates that there is an urgent need for discovery of new anti-TB entities, addressed towards new and specific targets, and continuous development of fast and efficient synthetic strategies to access them easily. Microwave-assisted chemistry is well suited for small-scale laboratory synthetic work, allowing full control of reaction conditions, such as temperature, pressure, and time. Microwave-assisted high-speed organic synthesis is especially useful in the lead optimization phase of drug discovery. To illustrate the advantages of modern microwave heating technology, we herein describe applications and approaches that have been useful for the synthesis of new drug-like anti-TB compounds.
authors.affiliation: Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, BMC, Uppsala University , Uppsala , Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: De Rosa
authors.forename: Johan
authors.initials: J
authors.lastname: Gising
authors.forename: Luke R
authors.initials: LR
authors.lastname: Odell
authors.forename: Mats
authors.initials: M
authors.lastname: Larhed
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D006801:Humans; D008872:Microwaves; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents
keywords: Extensive drug resistance; Mycobacterium tuberculosis; microwave; multi-drug resistance; tuberculosis