title: A study of noninvasive positive-pressure mechanical ventilation in the treatment of acute lung injury with a complex critical care ventilator.
abstract: OBJECTIVE
  To test the hypothesis that there would be better clinical outcomes following the treatment of patients with acute lung injury (ALI) using noninvasive positive-pressure mechanical ventilation (NIPPV) delivered via a complex critical care ventilator compared with a conventional mini-ventilator.
  
  
  METHODS
  Patients with ALI who required NIPPV were prospectively enrolled and randomly divided between three intervention groups: group A was ventilated using a mini-ventilator; groups B and C were ventilated using a complex critical care ventilator using different settings. Clinical parameters were recorded before and after 8 h of mechanical ventilation.
  
  
  RESULTS
  A total of 51 patients with ALI were enrolled in the study. Clinical parameters in groups B and C underwent greater improvements than those in group A. Group C demonstrated the lowest treatment failure rate (23.5%). Failure rates were highest in group A (58.8%).
  
  
  CONCLUSIONS
  The findings of this present study suggest that there were more satisfactory clinical outcomes following the treatment of patients with ALI when NIPPV was delivered using a complex critical care ventilator compared with a conventional mini-ventilator.
authors.affiliation: Department of Respiratory Diseases, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Diseases, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Respiratory Diseases, General Hospital of Tianjin Medical University, Tianjin, China Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA zyyhxkfj@126.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Respiratory Diseases, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Respiratory Diseases, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Bao-Yuan
authors.initials: BY
authors.lastname: Chen
mesh_terms: D055371:Acute Lung Injury / Q000401:mortality / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D000328:Adult; D003422:Critical Care; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration / Q000295:instrumentation* / Q000379:methods; D011446:Prospective Studies; D012129:Respiratory Function Tests; D016019:Survival Analysis; D016896:Treatment Outcome; D012122:Ventilators, Mechanical
keywords: Noninvasive ventilation; acute lung injury; acute respiratory distress syndrome; mask; mechanical ventilation