title: Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys.
abstract: Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. The value of CR as a tool to understand human ageing relies on translatability of CR's effects in primates. Here we show that CR significantly improves age-related and all-cause survival in monkeys on a long-term ~30% restricted diet since young adulthood. These data contrast with observations in the 2012 NIA intramural study report, where a difference in survival was not detected between control-fed and CR monkeys. A comparison of body weight of control animals from both studies with each other, and against data collected in a multi-centred relational database of primate ageing, suggests that the NIA control monkeys were effectively undergoing CR. Our data indicate that the benefits of CR on ageing are conserved in primates.
authors.affiliation: Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA.
authors.forename: Ricki J
authors.initials: RJ
authors.lastname: Colman
authors.affiliation: 1] Geriatrics Research, Education and Clinical Center, Birmingham/Atlanta Veterans Administration Hospital, Birmingham, Alabama 35233, USA [2] Department of Biostatistics, University of Alabama, Birmingham, Alabama 35294, USA.
authors.forename: T Mark
authors.initials: TM
authors.lastname: Beasley
authors.affiliation: Department of Cell and Regenerative Biology, University of Wisconsin, Madison, Wisconsin 53706, USA.
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Kemnitz
authors.affiliation: 1] Geriatrics Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA [2] Department of Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA.
authors.forename: Sterling C
authors.initials: SC
authors.lastname: Johnson
authors.affiliation: 1] Geriatrics Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA [2] Department of Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Weindruch
authors.affiliation: 1] Geriatrics Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA [2] Department of Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA.
authors.forename: Rozalyn M
authors.initials: RM
authors.lastname: Anderson
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D031204:Caloric Restriction; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008136:Longevity; D008253:Macaca mulatta; D008297:Male; D009026:Mortality; D016019:Survival Analysis