title: Animal-type malignant melanoma associated with nevus of Ota in the orbit of a Japanese woman: a case report.
abstract: We present a patient with an animal-type malignant melanoma associated with the nevus of Ota in the orbit who showed a good prognosis after a combination of orbital extirpation, chemotherapy, stereotactic radiotherapy, and gamma knife. A 42-year-old Japanese woman presented with two tumors, one pathologically diagnosed as right-sided intraconal animal-type malignant melanoma and the other intracranially, presumed to be of the same pathogenesis and both were considered to have arisen from the nevus of Ota. She underwent an extirpation of the orbit, chemotherapy (DAV therapy, which is a combination of dacarbazine, nimustine, and vincristine), stereotactic radiotherapy (54 Gy in 27 fractions), and gamma knife (marginal dose was 17 Gy, target volume was 0.2 ml). She has been alive for 33 months since the extirpation, with no sign of local recurrence, new metastasis, nor enlargement of the intracranial tumor. Not just combination therapy but also the low malignancy of animal-type melanoma may have contributed toward the good prognosis.
authors.affiliation: aDepartment of Ophthalmology, Gunma University School of Medicine bClinical Department of Pathology, Gunma University Hospital, Gunma, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nitta
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kashima
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Mayuzumi
authors.forename: Hideo
authors.initials: H
authors.lastname: Akiyama
authors.forename: Tomomi
authors.initials: T
authors.lastname: Miyanaga
authors.forename: Junko
authors.initials: J
authors.lastname: Hirato
authors.forename: Shoji
authors.initials: S
authors.lastname: Kishi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000556:secondary* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D007564:Japan; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000556:secondary* / Q000628:therapy; D009507:Nevus of Ota / Q000473:pathology* / Q000628:therapy; D013508:Ophthalmologic Surgical Procedures; D009918:Orbital Neoplasms / Q000473:pathology* / Q000628:therapy; D016634:Radiosurgery; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome