title: Influence of oral contraceptives on anthropomorphometric, endocrine, and metabolic profiles of anovulatory polycystic ovary syndrome patients.
abstract: OBJECTIVE
  To evaluate the influence of oral contraceptive pills (OCPs) on anthromorphometric, endocrine, and metabolic parameters in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Retrospective cross-sectional cohort study for the period 1993-2011.
  
  
  METHODS
  Tertiary university hospital.
  
  
  METHODS
  PCOS patients, who never, ever, or at time of screening were using OCPs were included. A total of 1,297 patients, of whom 827 were white, were included. All PCOS patients diagnosed according to the Rotterdam 2003 consensus criteria were divided into three groups: current users, (n = 76; 6% of total), ever users (n = 1,018; 78%), and never users (n = 203; 16%). Ever users were subdivided based on the OCP-free interval.
  
  
  METHODS
  None.
  
  
  METHODS
  Anthromorphometric (blood pressure, cycle duration) and ultrasound (follicle count, mean ovarian volume) parameters, endocrine (SHBG, testosterone, free androgen index, antimüllerian hormone [AMH]) and lipid profiles.
  
  
  RESULTS
  Current users and ever users were compared with never users. In current users, SHBG was increased and androgen levels decreased. Patients with an OCP-free interval of <1 year had a higher mean follicle count, higher AMH level, and increased serum androgen level compared with never users. SHBG levels remained increased until 5-10 years after cessation of OCP use.
  
  
  CONCLUSIONS
  OCP use causes a milder phenotypic presentation of PCOS regarding hyperandrogenism. However, it does not alter parameters associated with increased health risks.
authors.affiliation: Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. Electronic address: mmeskrowinkel@gmail.com.
authors.forename: Miranda G
authors.initials: MG
authors.lastname: Mes-Krowinkel
authors.affiliation: Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Yvonne V
authors.initials: YV
authors.lastname: Louwers
authors.affiliation: Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Annemarie G M G J
authors.initials: AG
authors.lastname: Mulders
authors.affiliation: Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Frank H
authors.initials: FH
authors.lastname: de Jong
authors.affiliation: Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Bart C J M
authors.initials: BC
authors.lastname: Fauser
authors.affiliation: Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Joop S E
authors.initials: JS
authors.lastname: Laven
mesh_terms: D000328:Adult; D000858:Anovulation / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D054304:Anti-Mullerian Hormone / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008055:Lipids / Q000097:blood; D008597:Menstrual Cycle / Q000187:drug effects; D006080:Ovarian Follicle / Q000000981:diagnostic imaging / Q000187:drug effects; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D062606:Tertiary Care Centers; D013739:Testosterone / Q000097:blood; D016896:Treatment Outcome; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003278:Contraceptives, Oral, Hormonal; D008055:Lipids; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D054304:Anti-Mullerian Hormone
keywords: Polycystic ovary syndrome; endocrine profile; oral contraceptive pills