title: Central vestibular system modulation in vestibular migraine.
abstract: BACKGROUND
  Vestibular migraine affects 1% of the general population, and 30%-50% of all migraine patients describe occasionally associated vertigo or dizziness. We aimed to identify brain regions altered in vestibular migraine in order to evaluate the connection between migraine and the vestibular system.
  
  
  METHODS
  Seventeen patients with definite vestibular migraine were compared to 17 controls using magnetic resonance imaging-based voxel-based morphometry.
  
  
  RESULTS
  We found grey matter (GM) volume reduction in the superior, inferior and middle (MT/V5) temporal gyrus as well as in the mid. cingulate, dorsolateral prefontal, insula, parietal and occipital cortex. A negative correlation of disease duration and GM volume was observed in areas associated with pain and vestibular processing. Moreover, there was a negative correlation between headache severity and prefrontal cortex volume.
  
  
  CONCLUSIONS
  Alterations identified in vestibular migraine resemble those previously described for migraine, but also extend to areas involved in multisensory vestibular control and central vestibular compensation possibly representing the pathoanatomic connection between migraine and the vestibular system.
authors.affiliation: Department of Neurology, University of Duisburg-Essen, Germany mark.obermann@uni-due.de.
authors.forename: Mark
authors.initials: M
authors.lastname: Obermann
authors.affiliation: Department of Neurology, University of Duisburg-Essen, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Wurthmann
authors.affiliation: Department of Neurology, University of Duisburg-Essen, Germany.
authors.forename: Benedict Schulte
authors.initials: BS
authors.lastname: Steinberg
authors.affiliation: Institute for Diagnostic and Interventional Radiology and Neuroradiology, University of Duisburg-Essen, Germany.
authors.forename: Nina
authors.initials: N
authors.lastname: Theysohn
authors.affiliation: Department of Neurology, University of Duisburg-Essen, Germany.
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Diener
authors.affiliation: Department of Neurology, University of Duisburg-Essen, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Naegel
mesh_terms: D000328:Adult; D004244:Dizziness / Q000209:etiology; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000473:pathology*; D014717:Vertigo / Q000209:etiology; D055815:Young Adult
keywords: Voxel-based morphometry; dizziness; migraine; neuronal plasticity; pain processing; vertigo; vestibular migraine