title: Pd(II)-catalyzed mild C-H ortho arylation and intramolecular amination oriented by a phosphinamide group.
abstract: A novel protocol for the Pd-catalyzed ortho-arylation of aryl phosphinamide with boronic acid is reported. By using phosphinamide as a new directing group, the reaction proceeds efficiently under mild conditions at 408C. Mechanistic studies reveal that the reaction proceeds via a PdII to Pd0 cycle. The phosphinamide group is also shown to be an effective orienting group for direct C-H amination.
authors.forename: Jing
authors.initials: J
authors.lastname: Guan
authors.forename: Guo-Jie
authors.initials: GJ
authors.lastname: Wu
authors.forename: Fu-She
authors.initials: FS
authors.lastname: Han
mesh_terms: D000586:Amination; D001897:Boronic Acids / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D009943:Organophosphorus Compounds; D010165:Palladium