title: Early and late complications related to central venous catheters in hematological malignancies: a retrospective analysis of 1102 patients.
abstract: Several severe complications may be associated with the use of central venous catheters (CVC). We retrospectively evaluated on a large cohort of patients the incidence of CVC-related early and late complications. From 7/99 to 12/2005, 1102 CVC have been implanted at our Institution in 881 patients with hematological malignancies (142,202 total day number of implanted CVC). Early mechanic complications were 79 (7.2% - 0.55/1,000 days/CVC). Thirty-nine episodes of early infective complications (<1 week from CVC implant) occurred (3.5% - 0.3/1000 days/CVC): furthermore, 187 episodes of CVC-related sepsis (17% - 1.3/1000 days/CVC) were recorded. There were 29 episodes (2.6%) of symptomatic CVC-related thrombotic complications, with a median interval from CVC implant of 60 days (range 7 - 395). The rate of CVC withdrawal due to CVC-related complications was 26%. The incidence of CVC-related complications in our series is in the range reported in the literature notwithstanding cytopenia often coexisting in hematological patients.
authors.affiliation: Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" Università di Roma, Italy.
authors.forename: Salvatore Giacomo
authors.initials: SG
authors.lastname: Morano
authors.affiliation: Istituto di Ematologia "AOU" Sassari, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Coppola
authors.affiliation: Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" Università di Roma, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Latagliata
authors.affiliation: Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" Università di Roma, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Berneschi
authors.affiliation: Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" Università di Roma, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Chistolini
authors.affiliation: Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" Università di Roma, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Micozzi
authors.affiliation: Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" Università di Roma, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Girmenia
authors.affiliation: Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" Università di Roma, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Breccia
authors.affiliation: Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" Università di Roma, Italy.
authors.forename: Gregorio
authors.initials: G
authors.lastname: Brunetti
authors.affiliation: Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" Università di Roma, Italy.
authors.forename: Fulvio
authors.initials: F
authors.lastname: Massaro
authors.affiliation: Dipartimento Anestesia e Rianimazione, Azienda Policlinico Umberto I, "Sapienza" Università di Roma.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Rosa
authors.affiliation: Dipartimento Scienze Radiologiche, Azienda Policlinico Umberto I, "Sapienza" Università di Roma.
authors.forename: Pietro
authors.initials: P
authors.lastname: Guerrisi
authors.affiliation: Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" Università di Roma, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Mandelli
authors.affiliation: Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" Università di Roma, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Foà
authors.affiliation: Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" Università di Roma, Italy.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Alimena