title: Multifunctional gold nanorods for siRNA gene silencing and photothermal therapy.
abstract: Cancer is a complex disease that usually requires several treatment modalities. A multifunctional nanotherapeutic system is designed, incorporating small interfering RNA (siRNA) and gold nanorods (Au NRs) for photothermal therapy. Surface-engineered Au NRs with polyethylenimine are synthesized using a layer-by-layer assembly and siRNA is absorbed on the surface. The siRNA is efficiently delivered into breast cancer cells, resulting in subsequent gene silencing. Cells are then irradiated with near-infrared (NIR) light, causing heat-induced anticancer activity. The combination of gene silencing and photothermal therapy results in effective inhibition of cell proliferation.
authors.affiliation: MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, China; Department of Nanomedicine, Houston Methodist Research Institute, Houston, 77030, USA.
authors.forename: Jianliang
authors.initials: J
authors.lastname: Shen
authors.forename: Han-Cheon
authors.initials: HC
authors.lastname: Kim
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Mu
authors.forename: Emanuela
authors.initials: E
authors.lastname: Gentile
authors.forename: Junhua
authors.initials: J
authors.lastname: Mai
authors.forename: Joy
authors.initials: J
authors.lastname: Wolfram
authors.forename: Liang-nian
authors.initials: LN
authors.lastname: Ji
authors.forename: Mauro
authors.initials: M
authors.lastname: Ferrari
authors.forename: Zong-wan
authors.initials: ZW
authors.lastname: Mao
authors.forename: Haifa
authors.initials: H
authors.lastname: Shen
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000628:therapy*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D020868:Gene Silencing; D015316:Genetic Therapy / Q000379:methods*; D006046:Gold / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D043942:Nanotubes / Q000737:chemistry*; D010789:Phototherapy / Q000379:methods*; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry / Q000235:genetics
chemical_list: D034741:RNA, Small Interfering; D006046:Gold
keywords: gold nanorods; layer-by-layer assembly; photothermal therapy; siRNA