title: The "Pulse Time Index of Norm" highly correlates with the left ventricular mass index in patients with arterial hypertension.
abstract: BACKGROUND
  Arterial stiffness, as measured by the pulse wave velocity (PWV), is recommended for routine use in clinical practice as an important parameter for the evaluation of cardiovascular risk.1 New 24-hour monitors (eg, with Vasotens technology; Petr Telegin Company, Nizhny Novgorod, Russian Federation) provide single PWV measurements as well as several PWV measurements over a period of 24 hours.2 Such 24-hour pulse wave analysis led to the development of the novel Pulse Time Index of Norm (PTIN), which is defined as the percentage of a 24-hour period during which the PWV does not exceed the 10 m/second PWV threshold. The aim of this study is to test the new PTIN for correlation with the left ventricular mass index (LVMI).
  
  
  METHODS
  Oscillometrically generated waveform files (n=137) used for clinical research studies were reanalyzed using the new 2013 version of the Vasotens technology program, which enables PTIN calculations.
  
  
  RESULTS
  A good correlation (r=-0.72) between the PTIN and the LVMI was shown, which was significantly above the blood pressure load (r=0.41).
  
  
  CONCLUSIONS
  The PTIN generated by the Vasotens technology can be recommended as an indicator of end organ damage via hypertension.
authors.affiliation: Hemodynamic Laboratory Ltd, Nizhny Novgorod, Russia.
authors.forename: Igor N
authors.initials: IN
authors.lastname: Posokhov
authors.affiliation: 3rd Republican Hospital, Saransk, Russia.
authors.forename: Natalya N
authors.initials: NN
authors.lastname: Kulikova
authors.affiliation: 3rd Republican Hospital, Saransk, Russia.
authors.forename: Irina V
authors.initials: IV
authors.lastname: Starchenkova
authors.affiliation: Chelyabinsk State Medical Academy, Chelyabinsk, Russia.
authors.forename: Elena A
authors.initials: EA
authors.lastname: Grigoricheva
authors.affiliation: Chelyabinsk State Medical Academy, Chelyabinsk, Russia.
authors.forename: Vitaly V
authors.initials: VV
authors.lastname: Evdokimov
authors.affiliation: National Research Nuclear University MEPhl, Moscow, Russia.
authors.forename: Artemy V
authors.initials: AV
authors.lastname: Orlov
authors.affiliation: Cardiology Research Center, Moscow, Russia.
authors.forename: Anatoly N
authors.initials: AN
authors.lastname: Rogoza
mesh_terms: D000328:Adult; D062186:Arterial Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009991:Oscillometry; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis; D012042:Registries; D012307:Risk Factors; D013997:Time Factors; D014463:Ultrasonography; D059289:Vascular Stiffness
keywords: 24-hour; LVMI; PTIN; ambulatory; arterial stiffness; monitoring; pulse wave velocity