title: Metal-free direct trifluoromethylation of activated alkenes with Langlois' reagent leading to CF3-containing oxindoles.
abstract: A metal-free and cost-effective synthesis protocol has been initially proposed for the construction of CF3-containing oxindoles via the direct oxidative trifluoromethylation of activated alkenes with Langlois' reagent (CF3SO2Na). The present methodology, which utilizes very cheap CF3 reagent and a simple oxidant, provides a convenient and practical approach to CF3-containing oxindoles with a wide variety of functional groups.
authors.affiliation: The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University , Qufu 273165, Shandong China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Jiangwei
authors.initials: J
authors.lastname: Wen
authors.forename: Daoshan
authors.initials: D
authors.lastname: Yang
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Liu
authors.forename: Mengyuan
authors.initials: M
authors.lastname: Guo
authors.forename: Ruimei
authors.initials: R
authors.lastname: Dong
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D005617:Chlorofluorocarbons, Methane / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008745:Methylation; D008968:Molecular Conformation; D000078183:Oxindoles
chemical_list: D000475:Alkenes; D005617:Chlorofluorocarbons, Methane; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole