title: Treatment of mild and moderate type-2 diabetes: open prospective trial with Hintonia latiflora extract.
abstract: BACKGROUND
  Extracts from the bark of Hintonia latiflora are used as dietetic measures to support the regulation of glucose metabolism and the stabilization of blood glucose values.
  
  
  METHODS
  A dry concentrated extract from the bark of Hintonia latiflora in capsule form was tested in an open, prospective clinical study in 41 dietetically stabilized subjects with type 2 diabetes. The effects on parameters of blood glucose control were documented over a period of six months.
  
  
  RESULTS
  Fasting and postprandial glucose and the HbA1c value declined significantly. In the case of HbA1c, this meant a reduction of the absolute value from 7.49 ± 0.72% to 6.82 ± 0.67% (from 58.4 to 51.0 mmol/mol Hb; intention to treat (ITT) population). Furthermore, cholesterol and triglycerides were slightly reduced and no negative effect on other laboratory parameters and no change of the liver values were observed. Tolerance was very good. In particular, no side effects and no hypoglycemic episodes or worsening of diabetic symptoms occurred.
  
  
  CONCLUSIONS
  The study confirms the positive effect of extracts from the bark of Hintonia latiflora on blood glucose values suggesting a potential benefit in the management of glucose metabolism in cases of type 2 diabetes.
  
  
  BACKGROUND
  Reg.-No. ISRCTN83308122.
authors.affiliation: Head of Diabetes Department, IDF President, Rc: 425201/734, Vel'komoravská 2, Trencin, SK 91101, Slovak Republic. statistika.hladikova@seznam.cz.
authors.forename: Marta
authors.initials: M
authors.lastname: Korecova
authors.forename: Marie
authors.initials: M
authors.lastname: Hladikova
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods*; D024301:Plant Bark; D010936:Plant Extracts / Q000627:therapeutic use*; D019666:Rubiaceae
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts