title: [The correlation between serum uric acid level and abdominal obesity or metabolic syndrome].
abstract: OBJECTIVE
  To investigate the relationship between serum uric acid (UA) level and abdominal obesity or metabolic syndrome (MS).
  
  
  METHODS
  A total of 875 subjects, with 350 males and 525 females, aged 40-65 years old, were enrolled in this study. The clinical and biochemical data were collected and MRI was used to assess the visceral and subcutaneous adipose tissues. The relationships between UA level and abdominal obesity or MS were analyzed, and the cut-off values of UA for abdominal obesity and MS were determined.
  
  
  RESULTS
  Raised risks of abdominal obesity(OR = 4.35, 95%CI 1.91-9.90 in males; OR = 5.44, 95%CI 2.41-12.31 in females) and MS(OR = 4.47, 95%CI 2.08-9.62 in males; OR = 11.62, 95%CI 3.43-39.37 in females) were observed with the increase of UA level. The multiple logistic regression analysis showed that UA was an independent risk factor for hypertriglyceridemia(OR = 2.23, 95%CI 1.02-4.87 in males; OR = 3.04, 95%CI 1.49-6.23 in females) in all subjects and for abdominal obesity(OR = 3.23, 95%CI 1.32-7.91) and hypertension (OR = 2.35, 95%CI 1.37-4.05) in the females. Among the females, the regression line analyzed by simple correlation indicated that the UA level of 244.0 µmol/L was corresponded to the visceral adipose tissue area of 80 cm(2). The optimal cut-off point of UA for the diagnosis of MS was 258.8 µmol/L determined by the receiver operating characteristic curve.
  
  
  CONCLUSIONS
  The level of UA is closely correlated with abdominal obesity and MS in the middle-aged Chinese. The elevated UA level is an independent risk factor for abdominal obesity and MS in the female.
authors.forename: Xueyao
authors.initials: X
authors.lastname: Yin
authors.forename: Jiaqiang
authors.initials: J
authors.lastname: Zhou
authors.forename: Dan
authors.initials: D
authors.lastname: Yu
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Pan
authors.forename: Xuehong
authors.initials: X
authors.lastname: Dong
authors.forename: Fenping
authors.initials: F
authors.lastname: Zheng
authors.affiliation: Department of Endocrinology, the Sir Run Run Shaw Hospital affiliated to Medical College of Zhejiang University, Hangzhou 310016, China. Email: lihongheyi@126.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood / Q000453:epidemiology*; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid