title: Autologous bone marrow stromal cell transplantation for central nervous system disorders - recent progress and perspective for clinical application.
abstract: There is increasing evidence that the transplanted BMSC significantly promote functional recovery after CNS damage in the animal models of various kinds of CNS disorders, including cerebral infarct, traumatic brain injury and spinal cord injury. However, there are several shortages of information when considering clinical application of BMSC transplantation for patients with CNS disorders. In this review, therefore, we discuss what we should clarify to establish cell transplantation therapy as the scientifically proven entity in clinical situation and describe our recent works for this purpose. The BMSC have the ability to alter their gene expression profile and phenotype in response to the surrounding circumstances and to protect the neurons by producing some neurotrophic factors. They also promote neurite extension and rebuild the neural circuits in the injured CNS. The BMSC can be expanded in vitro using the animal serum-free medium. Pharmacological modulation may accelerate the in vitro proliferation of the BMSC. Using in vivo optical imaging technique, the transplanted BMSC can non-invasively be tracked in the living animals for at least 8 weeks after transplantation. It is urgent issues to develop clinical imaging technique to track the transplanted cells in the CNS and evaluate the therapeutic significance of BMSC transplantation in order to establish it as a definite therapeutic strategy in clinical situation in the future.
authors.affiliation: Department of Neurosurgery, Hokkaido University Graduate School of Medicine , Sapporo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kuroda
authors.affiliation: Department of Neurosurgery, Hokkaido University Graduate School of Medicine , Sapporo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Shichinohe
authors.affiliation: Department of Neurosurgery, Hokkaido University Graduate School of Medicine , Sapporo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Houkin
authors.affiliation: Department of Neurosurgery, Hokkaido University Graduate School of Medicine , Sapporo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iwasaki
keywords: Bone marrow stromal cell; cerebral stroke; spinal cord injury; translational study; transplantation