title: Label-free biosensing over a wide concentration range with photonic force microscopy.
abstract: We present a label-free biosensor that measures molecular interactions between biomolecules on the surface of a probe bead and substrate over a wide concentration range. This system is capable of detecting target biomolecules with concentrations varying from 10 nM to 0.1 pM, with high selectivity and sensitivity.
authors.affiliation: Graduate School of Nanoscience & Technology (WCU), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Republic of Korea).
authors.forename: Seungjin
authors.initials: S
authors.lastname: Heo
authors.forename: Kipom
authors.initials: K
authors.lastname: Kim
authors.forename: Yong-Hoon
authors.initials: YH
authors.lastname: Cho
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D019921:Biotinylation; D004247:DNA / Q000737:chemistry*; D018076:DNA, Complementary / Q000737:chemistry; D018625:Microscopy, Atomic Force / Q000295:instrumentation* / Q000379:methods*; D052898:Optical Tweezers; D012680:Sensitivity and Specificity
chemical_list: D018076:DNA, Complementary; D004247:DNA
keywords: biosensors; optical tweezers; photonic force microscopy; scanning force microscopy; single-molecule studies