title: THADA gene polymorphism and prostate cancer risk: a meta-analysis.
abstract: BACKGROUND
  The single nucleotide polymorphism (SNP) rs1465618 in THADA at 2p21 has been identified as being associated with prostate cancer (PCa) risk in Europeans; however, it is not clear whether the SNP is related to PCa risk in multiple populations. We investigated the association of rs1465618 in THADA with PCa in a Chinese population and carried out a meta-analysis in multiple populations, testing the relevance of this SNP for PCa risk.
  
  
  METHODS
  We genotyped the SNP using high resolution melting (HRM) analysis and assessed its association with PCa risk in a case-control study of 289 PCa patients and 288 controls in a Chinese population. A meta-analysis was carried out with 36,313 PCa patients and 36,485 controls to evaluate the association of rs1465618 with PCa risk in multiple populations.
  
  
  RESULTS
  rs1465618 in THADA was significantly associated with PCa risk (p = 0.026; odds ratio (OR) 1.327, 95% confidence interval (CI) 1.035-1.700). Furthermore, the rs1465618 variant genotype was associated with PCa aggressiveness (p = 0.044; OR = 2.053, 95% CI = 1.015-6.602) in the Chinese population. The meta-analysis showed that rs1465618 was significantly associated with PCa risk in multiple populations (p = 1.0×10(-8); OR = 1.127, 95% CI = 1.085-1.171).
  
  
  CONCLUSIONS
  Our results showed that rs1465618 in THADA may be a shared susceptibility variant for PCa in multiple populations. THADA gene polymorphisms may impact PCa susceptibility and progression.
authors.affiliation: The Fifth School of Clinical Medicine, Peking University, Beijing, China [corrected].
authors.forename: Fan
authors.initials: F
authors.lastname: Zhao
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.forename: Kuo
authors.initials: K
authors.lastname: Yang
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Dong
authors.initials: D
authors.lastname: Wei
authors.forename: Yaoguang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Shi
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Siying
authors.initials: S
authors.lastname: Liang
authors.forename: Chengxiao
authors.initials: C
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Zhu
authors.forename: Nana
authors.initials: N
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: Hui
authors.forename: Yurong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.forename: Yige
authors.initials: Y
authors.lastname: Yang
authors.forename: Lei
authors.initials: L
authors.lastname: Tang
authors.forename: Jianye
authors.initials: J
authors.lastname: Wang
authors.forename: Ze
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D018570:Risk Assessment
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers; D009363:Neoplasm Proteins; C477698:THADA protein, human