title: Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system.
abstract: Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine expressed at barrier surfaces of the skin, gut, nose, lung, and the maternal/fetal interphase. At these sites, it is important for the generation and maintenance of non-inflammatory, tissue-resident dendritic cell responses. We show here that TSLP is also expressed in the central nervous system (CNS) where it is produced by choroid plexus epithelial cells and astrocytes in the spinal cord. Under conditions of low-grade myelin degeneration, the numbers of TSLP-expressing astrocytes increase, and microglia express transcripts for the functional TSLP receptor dimer indicating that these cells are targets for TSLP in the myelin-degenerative CNS.
authors.affiliation: Medical University Vienna, Center for Brain Research, Department of Neuroimmunology, Spitalgasse 4, 1090, Vienna, Austria.
authors.forename: Maja
authors.initials: M
authors.lastname: Kitic
authors.forename: Isabella
authors.initials: I
authors.lastname: Wimmer
authors.forename: Milena
authors.initials: M
authors.lastname: Adzemovic
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Kögl
authors.forename: Antonia
authors.initials: A
authors.lastname: Rudel
authors.forename: Hans
authors.initials: H
authors.lastname: Lassmann
authors.forename: Monika
authors.initials: M
authors.lastname: Bradl
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000502:physiology; D002478:Cells, Cultured; D002831:Choroid Plexus / Q000502:physiology* / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism*; D004847:Epithelial Cells / Q000502:physiology; D017628:Microglia / Q000502:physiology; D018991:Myelin Proteolipid Protein / Q000235:genetics / Q000378:metabolism; D009186:Myelin Sheath / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D012333:RNA, Messenger / Q000378:metabolism; D011917:Rats, Inbred Lew; D055647:Rats, Transgenic; D018121:Receptors, Cytokine / Q000378:metabolism; D013116:Spinal Cord / Q000502:physiology* / Q000503:physiopathology; D000094632:Thymic Stromal Lymphopoietin
chemical_list: C498764:Crlf2 protein, rat; D016207:Cytokines; D018991:Myelin Proteolipid Protein; C489071:Plp1 protein, rat; D012333:RNA, Messenger; D018121:Receptors, Cytokine; D000094632:Thymic Stromal Lymphopoietin; C000721968:TSLP protein, rat
keywords: astrocytes; microglia; myelin degeneration; thymic stromal lymphopoietin