title: Clinical significance of optic disc progression by topographic change analysis maps in glaucoma: an 8-year follow-up study.
abstract: Aim. To investigate the ability of Heidelberg Retina Tomograph (HRT3) Topographic Change Analysis (TCA) map to predict the subsequent development of clinical change, in patients with glaucoma. Materials. 61 eyes of 61 patients, which, from a retrospective review were defined as stable on optic nerve head (ONH) stereophotographs and visual field (VF), were enrolled in a prospective study. Eyes were classified as TCA-stable or TCA-progressed based on the TCA map. All patients underwent HRT3, VF, and ONH stereophotography at 9-12 months intervals. Clinical glaucoma progression was determined by masked assessment of ONH stereophotographs and VF Guided Progression Analysis. Results. The median (IQR) total HRT follow-up period was 8.1 (7.3, 9.1) years, which included a median retrospective and prospective follow-up time of 3.9 (3.1, 5.0) and 4.0 (3.5, 4.7) years, respectively. In the TCA-stable eyes, VF and/or photographic progression occurred in 5/13 (38.4%) eyes compared to 11/48 (22.9%) of the TCA-progressed eyes. There was no statistically significant association between TCA progression and clinically relevant (photographic and/or VF) progression (hazard ratio, 1.18; P = 0.762). The observed median time to clinical progression from enrollment was significantly shorter in the TCA-progressed group compared to the TCA-stable group (P = 0.04). Conclusion. Our results indicate that the commercially available TCA progression criteria do not adequately predict subsequent photographic and/or VF progression.
authors.affiliation: Department of Ophthalmology, 401 Hellenic Army General Hospital, 138 Mesogion & Katehaki Avenue, 11525 Athens, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Kourkoutas
authors.affiliation: Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8.
authors.forename: Y M
authors.initials: YM
authors.lastname: Buys
authors.affiliation: Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8.
authors.forename: J G
authors.initials: JG
authors.lastname: Flanagan
authors.affiliation: Department of Ophthalmology, 401 Hellenic Army General Hospital, 138 Mesogion & Katehaki Avenue, 11525 Athens, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Karamaounas
authors.affiliation: 1st Department of Ophthalmology, Medical School, University of Athens, 154 Mesogion Avenue, 11527 Athens, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Georgopoulos
authors.affiliation: 1st Department of Ophthalmology, Medical School, University of Athens, 154 Mesogion Avenue, 11527 Athens, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Iliakis
authors.affiliation: 1st Department of Ophthalmology, Medical School, University of Athens, 154 Mesogion Avenue, 11527 Athens, Greece.
authors.forename: M M
authors.initials: MM
authors.lastname: Moschos
authors.affiliation: Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8.
authors.forename: G E
authors.initials: GE
authors.lastname: Trope