title: Directed axonal outgrowth using a propagating gradient of IGF-1.
abstract: The temporospatial regulation of axon outgrowth is useful for guiding de novo connectivity or re-connectivity of neurons in neurological injury or disease. Here we report the successful construction of a biocompatible guidance device, in which a linear propagation of IGF-1 gradient sequentially directs axon outgrowth. We observe the extensive in vitro axonal extension over 5 mm with a desired growth rate of ∼ 1 mm/day.
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, CA, USA.
authors.forename: Wonjae
authors.initials: W
authors.lastname: Lee
authors.forename: Curtis W
authors.initials: CW
authors.lastname: Frank
authors.forename: Jon
authors.initials: J
authors.lastname: Park
mesh_terms: D001369:Axons / Q000187:drug effects* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry; D065546:Drug Liberation; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000737:chemistry / Q000494:pharmacology*; D019344:Lactic Acid / Q000737:chemistry; D009046:Motor Neurons / Q000166:cytology; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D007334:Insulin-Like Growth Factor I
keywords: axon guidance; controlled drug release; hydrogel; tissue engineering