title: Cartilage-forming tumors.
abstract: Cartilage-forming tumors as a group are the most common primary bone tumors; this is largely due to the common occurrence of asymptomatic benign lesions such as osteochondroma and enchondroma. The common feature of these tumors is the presence of chondrocytic cells and the formation of cartilaginous tumor matrix. Some of these tumors are true neoplasms while others are hamartomas or developmental abnormalities. The morphologic heterogeneity of these tumors may be explained by a common multipotent mesenchymal cell differentiating along the lines of fetal-adult cartilage maturation. Recently mutations in IDH1 and IDH2 have been detected in a variety of benign and malignant cartilaginous tumors.(1-4.)
authors.affiliation: Department of Pathology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, North Carolina 27157. Electronic address: sqasem@wakehealth.edu.
authors.forename: Shadi A
authors.initials: SA
authors.lastname: Qasem
authors.affiliation: Department of Pathology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, North Carolina 27157.
authors.forename: Barry R
authors.initials: BR
authors.lastname: DeYoung
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D002356:Cartilage / Q000473:pathology*; D002804:Chondroblastoma / Q000175:diagnosis / Q000473:pathology; D002812:Chondroma / Q000175:diagnosis / Q000473:pathology; D002813:Chondrosarcoma / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D015831:Osteochondroma / Q000175:diagnosis / Q000473:pathology
keywords: Chest wall hamartoma; Chondroblastoma; Chondroma; Chondromyxoid fibroma; Chondrosarcoma; Osteochondroma