title: Role of intrahepatic innervation in regulating the activity of liver cells.
abstract: Liver innervation comprises sympathetic, parasympathetic and peptidergic nerve fibers, organized as either afferent or efferent nerves with different origins and roles. Their anatomy and physiology have been studied in the past 30 years, with different results published over time. Hepatocytes are the main cell population of the liver, making up almost 80% of the total liver volume. The interaction between hepatocytes and nerve fibers is accomplished through a wealth of neurotransmitters and signaling pathways. In this short review, we have taken the task of condensing the most important data related to how the nervous system interacts with the liver and especially with the hepatocyte population, how it influences their metabolism and functions, and how different receptors and transmitters are involved in this complex process.
authors.affiliation: Letitia Adela Maria Streba, Alin Gabriel Ionescu, University of Medicine and Pharmacy of Craiova, 200348 Craiova, Romania.
authors.forename: Letitia Adela Maria
authors.initials: LA
authors.lastname: Streba
authors.affiliation: Letitia Adela Maria Streba, Alin Gabriel Ionescu, University of Medicine and Pharmacy of Craiova, 200348 Craiova, Romania.
authors.forename: Cristin Constantin
authors.initials: CC
authors.lastname: Vere
authors.affiliation: Letitia Adela Maria Streba, Alin Gabriel Ionescu, University of Medicine and Pharmacy of Craiova, 200348 Craiova, Romania.
authors.forename: Alin Gabriel
authors.initials: AG
authors.lastname: Ionescu
authors.affiliation: Letitia Adela Maria Streba, Alin Gabriel Ionescu, University of Medicine and Pharmacy of Craiova, 200348 Craiova, Romania.
authors.forename: Costin Teodor
authors.initials: CT
authors.lastname: Streba
authors.affiliation: Letitia Adela Maria Streba, Alin Gabriel Ionescu, University of Medicine and Pharmacy of Craiova, 200348 Craiova, Romania.
authors.forename: Ion
authors.initials: I
authors.lastname: Rogoveanu
keywords: Cellular receptors; Hepatocytes; Liver innervations; Neurotransmitters