title: Chemerin levels as predictor of acute coronary events: a case-control study nested within the veterans affairs normative aging study.
abstract: OBJECTIVE
  Chemerin is a recently identified adipocytokine that has been positively correlated with the presence and severity of coronary artery disease (CAD). However, no studies have examined circulating chemerin levels as a predictor of acute coronary syndrome (ACS). The purpose of this study is to evaluate whether chemerin levels predict the onset of ACS.
  
  
  METHODS
  We studied 90 men whose serum had been collected at least 2 years before the development of ACS, and 162 controls matched with the cases in a 1:2 fashion for age and year of collection. The mean age of the cohort was 66.3±9.6 years (range 34-84 years). Serum chemerin levels were measured with a commercially available enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Age was positively associated with chemerin levels (r=0.39, p<0.001). Logistic regression analysis, adjusting for years since blood collection, demonstrated a null association between chemerin levels and the odds ratio for development of ACS (OR: 0.99, 95% CI [0.99-1.001]). This association remained null after adjusting for age (OR: 0.99 95% CI [0.99-1.001]).
  
  
  CONCLUSIONS
  Although cross-sectional and case-control studies suggest a positive association between chemerin levels and CAD, we demonstrate that chemerin levels do not predict the development of ACS.
authors.affiliation: Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School; Division of Endocrinology Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School; Department of Medicine, Boston Medical Center, Boston University School of Medicine. Electronic address: konstantinos.aronis@bmc.org.
authors.forename: Konstantinos N
authors.initials: KN
authors.lastname: Aronis
authors.affiliation: Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School; Division of Endocrinology Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School.
authors.forename: Ayse
authors.initials: A
authors.lastname: Sahin-Efe
authors.affiliation: Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School; Division of Endocrinology Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School.
authors.forename: John P
authors.initials: JP
authors.lastname: Chamberland
authors.affiliation: Normative Aging Study, VA Boston Healthcare System and Boston University Schools of Public Health and Medicine.
authors.forename: Avron
authors.initials: A
authors.lastname: Spiro
authors.affiliation: Normative Aging Study, VA Boston Healthcare System and Boston University School of Medicine.
authors.forename: Pantel
authors.initials: P
authors.lastname: Vokonas
authors.affiliation: Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School; Division of Endocrinology Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School; Department of Medicine, Boston Medical Center, Boston University School of Medicine.
authors.forename: Christos S
authors.initials: CS
authors.lastname: Mantzoros
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D014481:United States / Q000453:epidemiology; D014728:Veterans / Q000706:statistics & numerical data*
chemical_list: D015415:Biomarkers; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human
keywords: Acute Coronary Events; Chemerin; Normative Aging Study