title: RASSF1A methylation may have two biological roles in neuroblastoma tumorigenesis depending on the ploidy status and age of patients.
abstract: RASSF1A methylation was frequent in neuroblastomas found in infants by mass-screening or infants and children diagnosed clinically, whereas CASP8 and DCR2 methylation was only frequent in tumors in children. When classified according to the ploidy status, RASSF1A and PCDHB methylation was only associated with MYCN amplification and poor outcomes in infants with a clinically diagnosed diploid, not triploid tumor. RASSF1A and PCDHB methylation was associated with poor outcomes in children with triploid and diploid tumors, respectively, and with MYCN amplification in children with diploid tumor. RASSF1A methylation may have two biological roles based on the ploidy status and patient's age.
authors.affiliation: Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Haruta
authors.affiliation: Research Institute, Chiba Cancer Center, Chiba, Japan.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Kamijo
authors.affiliation: Research Institute, Chiba Cancer Center, Chiba, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Nakagawara
authors.affiliation: Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan. Electronic address: kaneko@cancer-c.pref.saitama.jp.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kaneko
mesh_terms: D000367:Age Factors; D053181:Caspase 8 / Q000235:genetics; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D053208:Kaplan-Meier Estimate; D015999:Multivariate Analysis; D000071447:N-Myc Proto-Oncogene Protein; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics; D015513:Oncogene Proteins / Q000235:genetics; D010641:Phenotype; D011003:Ploidies; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D013997:Time Factors; D053319:Tumor Necrosis Factor Decoy Receptors / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C459801:MYCN protein, human; D000071447:N-Myc Proto-Oncogene Protein; D009687:Nuclear Proteins; D015513:Oncogene Proteins; C411762:RASSF1 protein, human; C451501:TNFRSF10D protein, human; D053319:Tumor Necrosis Factor Decoy Receptors; D025521:Tumor Suppressor Proteins; C505530:CASP8 protein, human; D053181:Caspase 8
keywords: Diploid; Mass-screening; Neuroblastoma; RASSF1A methylation; Triploid