title: The cough suppressive activity of sulfated glucuronoxylan from Fagus sylvatica L.
abstract: Hemicellulose polysaccharides represent a large group of natural renewable polymers, however, their application potency is still low. In our study a hardwood 4-O-methylglucuronoxylan was isolated by alkali peroxide extraction of Fagus sylvatica sawdust and modified into sulfated water soluble derivative (MGXS). Highly sulfated MGXS was characterized by HPLC, FTIR and NMR spectroscopies, and tested in vivo on chemically induced cough reflex and smooth muscles reactivity. Farmacological tests revealed an interesting antitussive activity of MGXS. Comparative tests with drug commonly used in a clinical practice revealed that antitussive activity of MGXS was lower than that of opioid receptor agonist codeine, the strongest antitussive drug. Furthermore, the specific reactivity of airways smooth muscle was not significantly affected by MGXS, indicating thus that the polymer is not involved in the bronchodilation process.
authors.affiliation: Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, 036 01 Martin, Slovak Republic.
authors.forename: G
authors.initials: G
authors.lastname: Nosáľova
authors.affiliation: Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, 036 01 Martin, Slovak Republic.
authors.forename: L
authors.initials: L
authors.lastname: Jureček
authors.affiliation: Department of Glycomaterials, Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, 842 38 Bratislava, Slovak Republic.
authors.forename: J
authors.initials: J
authors.lastname: Turjan
authors.affiliation: Department of Glycomaterials, Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, 842 38 Bratislava, Slovak Republic. Electronic address: chemcape@savba.sk.
authors.forename: P
authors.initials: P
authors.lastname: Capek
authors.affiliation: Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, 036 01 Martin, Slovak Republic.
authors.forename: L
authors.initials: L
authors.lastname: Prisenžňáková
authors.affiliation: Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, 036 01 Martin, Slovak Republic.
authors.forename: S
authors.initials: S
authors.lastname: Fraňová
mesh_terms: D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage* / Q000737:chemistry; D003061:Codeine / Q000008:administration & dosage; D003371:Cough / Q000188:drug therapy*; D029964:Fagus / Q000737:chemistry; D006168:Guinea Pigs; D006801:Humans; D009130:Muscle, Smooth / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry; D014990:Xylans / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000996:Antitussive Agents; D010936:Plant Extracts; D013431:Sulfates; D014990:Xylans; C038910:glucuronoxylan; D003061:Codeine
keywords: Antitussive activity; Beech; Sulphated 4-O-methyl-glucuronoxylan