title: Endovascular treatment of unruptured wide-necked intracranial aneurysms: comparison of dual microcatheter technique and stent-assisted coil embolization.
abstract: BACKGROUND
  Endovascular treatment of wide-necked aneurysms is challenging. Stent-assisted coiling (SAC) is associated with increased complications and requires dual antiplatelet therapy.
  
  
  OBJECTIVE
  To compare treatment of unruptured, wide-necked aneurysms with a dual-microcatheter technique (DMT) versus SAC.
  
  
  METHODS
  Between 2006 and 2011, 100 patients with unruptured wide-necked intracranial aneurysms were treated with DMT and 160 with SAC. Over time there was a significant decrease in the use of SAC and a corresponding increase in DMT. The investigators matched 60 patients treated with DMT blinded to outcome in a 1:2 fashion based on maximal aneurysm dome diameter with 120 patients treated with SAC. Outcomes were determined with conditional (matched) multivariate analysis.
  
  
  RESULTS
  There were no significant differences in patient or aneurysm characteristics between cohorts, including aneurysm diameter, neck width, or volume. Overall packing density and coil volume achieved was not significantly different between cohorts. There were higher rates of overall complications in those receiving SAC (19.2%) compared with DMT (5.0%; p=0.012), but no significant difference in major complications (8.3% vs 1.7%, respectively; p=0.103). At a mean follow-up of 27.0 ± 18.9 months, rates of retreatment did not differ between DMT (15.1%) and SAC (17.7%). Delayed in-stent stenosis occurred in five patients and in-stent thrombosis in four patients treated with SAC. There was no difference in favorable functional outcome (modified Rankin score 0-2) between those treated with DMT (90.6%) compared with SAC (91.2%).
  
  
  CONCLUSIONS
  DMT and SAC are effective endovascular approaches for unruptured, wide-necked aneurysms; however, DMT may result in less morbidity. Further long-term studies are necessary to determine the optimal indications for these treatment options.
authors.affiliation: Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Starke
authors.affiliation: Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Durst
authors.affiliation: Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: Avery
authors.initials: A
authors.lastname: Evans
authors.affiliation: Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: Dale
authors.initials: D
authors.lastname: Ding
authors.affiliation: Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: Daniel M S
authors.initials: DM
authors.lastname: Raper
authors.affiliation: Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Jensen
authors.affiliation: Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Crowley
authors.affiliation: Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Liu
mesh_terms: D002404:Catheterization / Q000295:instrumentation / Q000379:methods; D004621:Embolization, Therapeutic / Q000379:methods*; D057510:Endovascular Procedures / Q000295:instrumentation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D015607:Stents; D016896:Treatment Outcome
keywords: Aneurysm; Catheter; Coil; Stenosis; Stent