title: GPCR signaling along the endocytic pathway.
abstract: Many G protein-coupled receptors (GPCRs) internalize after agonist-induced activation. While endocytosis has long been associated with homeostatic attenuation of cellular responsiveness, accumulating evidence from study of a wide range of eukaryotes reveals that the endocytic pathway also contributes to generating receptor-initiated signals themselves. Here we review recent progress in this area, discussing primarily but not exclusively GPCR signaling in mammalian cells.
authors.affiliation: Department of Psychiatry, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA; Department of Cellular & Molecular Pharmacology, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA.
authors.forename: Roshanak
authors.initials: R
authors.lastname: Irannejad
authors.affiliation: Department of Psychiatry, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA; Department of Cellular & Molecular Pharmacology, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA. Electronic address: mark.vonzastrow@ucsf.edu.
authors.forename: Mark
authors.initials: M
authors.lastname: von Zastrow
mesh_terms: D000818:Animals; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D043562:Receptors, G-Protein-Coupled