title: Hemodiafiltration combined with resin-mediated absorption as a therapy for hyperlipidemic acute pancreatitis.
abstract: The aim of this study is to investigate whether hemodiafiltration combined with resin-mediated absorption is a better therapy for hyperlipidemic acute pancreatitis. Patients (n = 67) with acute pancreatitis treated in ICU from January 2009 to December 2012 were included in this study. Seven of these 67 cases were diagnosed hyperlipidemic acute pancreatitis (HLAP). All the 7 HLAP patients went through fast, gastrointestinal decompression, anti-shock treatment, inhibition of pancreatic secretion, antiseptic treatments, and hemoperfusion (HP) combined with continuous veno venous hemodiafiltration (CVVHDF). After one round of treatment by resin adsorption, there was a significant decrease in serum triglycerides (TG) (29.78 %) and total cholesterol (TC) (24.02 %) levels (p < 0.01). TG and TC levels dropped by 49.02 and 37.66 %, respectively, after 1-day treatment of HP + CVVHDF; by 62.81 and 47.37 % on day 2 post-treatment; and by 69.57 and 49.47 % on day 3 post-treatment. All the 7 patients survived. The average time spent in the ICU was 7 ± 3.8 days, and the average duration of hospitalization was 19 ± 15.1 days. Our results show that hemoperfusion combined with hemodiafiltration is an efficient treatment as this approach can reduce plasma lipid levels effectively and reduce the risk of acute pancreatitis due to hyperlipidemia.
authors.affiliation: Department of Intensive Care, Xuzhou Central Hospital, Xuzhou Hospital Affiliated to School of Medicine, Southeast University, 199 Jie Fang Road Xuzhou, Jiangsu, China, limaoqinxi@126.com.
authors.forename: Mao-qin
authors.initials: MQ
authors.lastname: Li
authors.forename: Zai-xiang
authors.initials: ZX
authors.lastname: Shi
authors.forename: Ji-yuan
authors.initials: JY
authors.lastname: Xu
authors.forename: Bo
authors.initials: B
authors.lastname: Lu
authors.forename: Jia-qiong
authors.initials: JQ
authors.lastname: Li
authors.forename: Yan-jun
authors.initials: YJ
authors.lastname: Xu
authors.forename: Xiao-Meng
authors.initials: XM
authors.lastname: Wang
authors.forename: Song-mei
authors.initials: SM
authors.lastname: Li
authors.forename: Xun
authors.initials: X
authors.lastname: Mo
mesh_terms: D065966:Absorption, Physicochemical; D000208:Acute Disease; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D017583:Hemodiafiltration; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications* / Q000378:metabolism / Q000628:therapy*; D012117:Resins, Synthetic / Q000737:chemistry*
chemical_list: D012117:Resins, Synthetic