title: Influence of different methods of internal bone fixation on characteristics of bone callus in experimental animals.
abstract: BACKGROUND
  Correct choice of osteosynthesis method is a very important factor in providing the optimal conditions for appropriate healing of the fracture. There are still disagreements about the method of stabilization of some long bone fractures. Critically observed, no method of fracture fixation is ideal. Each osteosynthesis method has both advantages and weaknesses.
  
  
  OBJECTIVE
  The objective of this study was to compare the results of the experimental application of three different internal fixation methods: plate fixation, intramedullary nail fixation and self-dynamisable internal fixator (SIF).
  
  
  METHODS
  A series of 30 animals were used (Lepus cuniculus) as experimental animals, divided into three groups of ten animals each. Femoral diaphysis of each animal was osteotomized and fixed with one of three implants. Ten weeks later all animals were sacrificed and each specimen underwent histological and biomechanical testing.
  
  
  RESULTS
  Histology showed that the healing process with SIF was more complete and bone callus was more mature in comparison to other two methods. During biomechanical investigation (computerized bending stress test), it was documented with high statistical significance that using SIF led to stronger healing ten weeks after the operation.
  
  
  CONCLUSIONS
  According to the results obtained in this study, it can be concluded that SIF is a suitable method for fracture treatment.
authors.forename: Djordje
authors.initials: D
authors.lastname: Gajdobranski
authors.forename: Milorad
authors.initials: M
authors.lastname: Mitkovic
authors.forename: Nada
authors.initials: N
authors.lastname: Vucković
authors.forename: Miroslav
authors.initials: M
authors.lastname: Milankov
authors.forename: Slobodan
authors.initials: S
authors.lastname: Jovanović
authors.forename: Miodrag
authors.initials: M
authors.lastname: Manić
authors.forename: Milan
authors.initials: M
authors.lastname: Mitković
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001860:Bone Plates; D002146:Bony Callus / Q000473:pathology* / Q000503:physiopathology; D005269:Femur / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005593:Fracture Fixation, Internal / Q000379:methods*; D050723:Fractures, Bone / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D011817:Rabbits; D014945:Wound Healing