title: On the use of metal purine derivatives (M=Ir, Rh) for the selective labeling of nucleosides and nucleotides.
abstract: The reactions of neutral or cationic IrIII and RhIII derivatives of phenyl purine nucleobases with unsymmetrical alkynes produce new metallacycles in a predictable manner, which allows for the incorporation of either photoactive (anthracene or pyrene) or electroactive (ferrocene) labels in the nucleotide or nucleoside moiety. The reported methodology (metalation of the purine derivative and subsequent marker insertion) could be used for the postfunctionalization and unambiguous labeling of oligonucleotides.
authors.forename: Marta
authors.initials: M
authors.lastname: Valencia
authors.forename: Mamen
authors.initials: M
authors.lastname: Martín-Ortiz
authors.forename: Mar
authors.initials: M
authors.lastname: Gómez-Gallego
authors.forename: Carmen
authors.initials: C
authors.lastname: Ramírez de Arellano
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Sierra
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000873:Anthracenes / Q000138:chemical synthesis* / Q000737:chemistry; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011684:Purine Nucleosides / Q000138:chemical synthesis*; D011685:Purine Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D011721:Pyrenes / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000873:Anthracenes; D009942:Organometallic Compounds; D011684:Purine Nucleosides; D011685:Purine Nucleotides; D011721:Pyrenes; D007495:Iridium; D012238:Rhodium