title: Gene therapy for skin diseases.
abstract: The skin possesses qualities that make it desirable for gene therapy, and studies have focused on gene therapy for multiple cutaneous diseases. Gene therapy uses a vector to introduce genetic material into cells to alter gene expression, negating a pathological process. This can be accomplished with a variety of viral vectors or nonviral administrations. Although results are promising, there are several potential pitfalls that must be addressed to improve the safety profile to make gene therapy widely available clinically.
authors.affiliation: Department of Dermatology, Stanford School of Medicine, Palo Alto, California 94305.
authors.forename: Emily
authors.initials: E
authors.lastname: Gorell
authors.forename: Ngon
authors.initials: N
authors.lastname: Nguyen
authors.forename: Alfred
authors.initials: A
authors.lastname: Lane
authors.forename: Zurab
authors.initials: Z
authors.lastname: Siprashvili
mesh_terms: D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D012871:Skin Diseases / Q000235:genetics / Q000628:therapy*; D016896:Treatment Outcome; D014945:Wound Healing / Q000235:genetics