title: 1,5-Anhydro-D-glucitol predicts coronary artery disease prevalence and complexity.
abstract: BACKGROUND
  The relationship between hemoglobin A1c (HbA1c) levels and coronary artery disease (CAD) has previously been confirmed. Serum 1,5-anhydro-D-glucitol (1,5-AG) levels are a useful clinical marker for short-term glycemic status that reflect glycemic excursions with greater sensitivity compared with HbA1c, specifically in the postprandial state. Postprandial hyperglycemia is an important CAD risk factor. Thus, the aim of this study was to compare HbA1c with 1,5-AG as a CAD predictor.
  
  
  METHODS
  The subjects consisted of 336 consecutive patients who underwent their first coronary angiography between July 2011 and March 2013. The relationship between CAD prevalence and HbA1c as well as CAD prevalence and 1,5-AG levels was evaluated. The correlation between CAD complexity and HbA1c or 1,5-AG was also assessed. CAD complexity was evaluated by the SYNTAX score.
  
  
  RESULTS
  CAD patients presented with significantly lower 1,5-AG and higher HbA1c values than patients without CAD (11.6 μg/ml [6.1, 19.1] vs. 17.6 μg/ml [11.9, 25.0], p<0.001, and 6.0% [5.6, 7.1] vs. 5.7% [5.4, 6.2], p<0.001, respectively) (median [25th, 75th percentiles]). According to logistic regression analysis, 1,5-AG was a predictor of CAD prevalence (odds ratio 0.94, 95% confidence interval 0.90-0.97). However, HbA1c levels did not present a predictive value for CAD. Levels of 1,5-AG and HbA1c were significantly correlated with SYNTAX scores (ρ=-0.27, p<0.001; and ρ=0.23, p<0.001, respectively).
  
  
  CONCLUSIONS
  The use of 1,5-AG, may be superior to HbA1c in predicting CAD prevalence. Both 1,5-AG and HbA1c correlate with CAD complexity.
authors.affiliation: Division of Cardiovascular Medicine, National Center for Global Health and Medicine, Tokyo, Japan. Electronic address: ikedanobutaka@yahoo.co.jp.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Ikeda
authors.affiliation: Division of Cardiovascular Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Hara
authors.affiliation: Division of Cardiovascular Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Hiroi
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood*; D003847:Deoxyglucose / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D003847:Deoxyglucose; D006442:Glycated Hemoglobin; C006584:1,5-anhydroglucitol
keywords: 1,5-Anhydro-d-glucitol; Coronary artery disease; Hemoglobin A1c; SYNTAX score