title: Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation.
abstract: Herein we demonstrated that dinuclear zinc complexes could overcome drug resistance in R-HepG2 drug resistance hepatocellular carcinoma cells through induction of mitochondria-mediated apoptosis or by triggering mitochondria fragmentation, depletion of the membrane potential and intracellular ATP levels.
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou 510632, China. tchentf@jnu.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xie
authors.forename: Shenggui
authors.initials: S
authors.lastname: Liu
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Li
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.forename: Zuandi
authors.initials: Z
authors.lastname: Luo
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Fu
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Cao
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Lan
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zheng
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Chen
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D001554:Benzene / Q000737:chemistry*; D001562:Benzimidazoles / Q000737:chemistry; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D018360:Crystallography, X-Ray; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D008968:Molecular Conformation; D015032:Zinc / Q000737:chemistry*
chemical_list: D001562:Benzimidazoles; D056831:Coordination Complexes; D000255:Adenosine Triphosphate; C031000:benzimidazole; D015032:Zinc; D001554:Benzene