title: Mathematical modeling of calcium waves induced by mechanical stimulation in keratinocytes.
abstract: Recent studies have shown that the behavior of calcium in the epidermis is closely related to the conditions of the skin, especially the differentiation of the epidermal keratinocytes and the permeability barrier function, and therefore a correct understanding of the calcium dynamics is important in explaining epidermal homeostasis. Here we report on experimental observations of in vitro calcium waves in keratinocytes induced by mechanical stimulation, and present a mathematical model that can describe the experimentally observed wave behavior that includes finite-range wave propagation and a ring-shaped pattern. A mechanism of the ring formation hypothesized by our model may be related to similar calcium propagation patterns observed during the wound healing process in the epidermis. We discuss a possible extension of our model that may serve as a tool for investigating the mechanisms of various skin diseases.
authors.affiliation: Research Institute for Electronic Science, Hokkaido University, Sapporo, Japan; CREST, Japan Science and Technology Agency, Tokyo, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Graduate School of Science and Technology, Kanazawa University, Kanazawa, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Sanno
authors.affiliation: Graduate School of Science and Technology, Kanazawa University, Kanazawa, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sakai
authors.affiliation: Research Institute for Electronic Science, Hokkaido University, Sapporo, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sawabu
authors.affiliation: Shiseido Research Center, Shiseido Co., Ltd., Yokohama, Japan.
authors.forename: Moe
authors.initials: M
authors.lastname: Tsutsumi
authors.affiliation: Shiseido Research Center, Shiseido Co., Ltd., Yokohama, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Goto
authors.affiliation: Department of Physics, Graduate School of Science, Chiba University, Chiba, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kitahata
authors.affiliation: Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nakata
authors.affiliation: CREST, Japan Science and Technology Agency, Tokyo, Japan; Shiseido Research Center, Shiseido Co., Ltd., Yokohama, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Kumamoto
authors.affiliation: CREST, Japan Science and Technology Agency, Tokyo, Japan; Shiseido Research Center, Shiseido Co., Ltd., Yokohama, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Denda
authors.affiliation: Research Institute for Electronic Science, Hokkaido University, Sapporo, Japan; CREST, Japan Science and Technology Agency, Tokyo, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nagayama
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001696:Biomechanical Phenomena; D020013:Calcium Signaling; D000078404:Epidermal Cells; D017629:Gap Junctions / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000378:metabolism; D055595:Mechanical Phenomena; D008954:Models, Biological
chemical_list: D000255:Adenosine Triphosphate