title: Inhibition of amyloid fibril growth and dissolution of amyloid fibrils by curcumin-gold nanoparticles.
abstract: Inhibition of amyloid fibrillation and clearance of amyloid fibrils/plaques are essential for the prevention and treatment of various neurodegenerative disorders involving protein aggregation. Herein, we report curcumin-functionalized gold nanoparticles (Au-curcumin) of hydrodynamic diameter 10-25 nm, which serve to inhibit amyloid fibrillation and disintegrate/dissolve amyloid fibrils. In nanoparticle form, curcumin is water-soluble and can efficiently interact with amyloid protein/peptide, offering enhanced performance in inhibiting amyloid fibrillation and dissolving amyloid fibrils. Our results imply that nanoparticle-based artificial molecular chaperones may offer a promising therapeutic approach to combat neurodegenerative disease.
authors.affiliation: Centre for Advanced Materials, Indian Association for the Cultivation of Science, Kolkata-700032 (India).
authors.forename: Sharbari
authors.initials: S
authors.lastname: Palmal
authors.forename: Amit Ranjan
authors.initials: AR
authors.lastname: Maity
authors.forename: Brijesh Kumar
authors.initials: BK
authors.lastname: Singh
authors.forename: Sreetama
authors.initials: S
authors.lastname: Basu
authors.forename: Nihar R
authors.initials: NR
authors.lastname: Jana
authors.forename: Nikhil R
authors.initials: NR
authors.lastname: Jana
mesh_terms: D000595:Amino Acid Sequence; D000682:Amyloid / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure*; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology*; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012995:Solubility / Q000187:drug effects
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D006046:Gold; D003474:Curcumin
keywords: amyloid beta-peptides; amyloid fibrils; curcumin; fibril dissolution; gold nanoparticles; neurochemistry