title: The importance of sphingolipids and reactive oxygen species in cardiovascular development.
abstract: The heart is the first organ in the embryo to form. Its structural and functional complexity is the result of a thorough developmental program, where sphingolipids play an important role in cardiogenesis, heart maturation, angiogenesis, the regulation of vascular tone and vessel permeability. Sphingolipids are necessary for signal transduction and membrane microdomain formation. In addition, recent evidence suggests that sphingolipid metabolism is directly interconnected to the modulation of oxidative stress. However, cardiovascular development is highly sensitive to excessive reactive species production, and disturbances in sphingolipid metabolism can lead to abnormal development and cardiac disease. Therefore, in this review, we address the molecular link between sphingolipids and oxidative stress, connecting these pathways to cardiovascular development and cardiovascular disease.
authors.affiliation: Centro de Biotecnologia da Universidade Federal do Rio Grande do Sul, Departamento de Biologia Molecular e Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Joice
authors.initials: J
authors.lastname: de Faria Poloni
authors.forename: Henrique
authors.initials: H
authors.lastname: Chapola
authors.forename: Bruno César
authors.initials: BC
authors.lastname: Feltes
authors.forename: Diego
authors.initials: D
authors.lastname: Bonatto
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000196:embryology*; D006801:Humans; D051379:Mice; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D013107:Sphingolipids / Q000502:physiology*
chemical_list: D017382:Reactive Oxygen Species; D013107:Sphingolipids
keywords: Cardiogenesis; Cardiovascular development; ROS; Reactive oxygen species; Sphingolipids