title: Sweet's syndrome with idiopathic thrombocythemia.
abstract: Diagnosis of paraneoplastic skin syndromes associating neoplastic processes is assumed as the crucial aspect of dermatological practice. Knowledge of clinical findings of dermatoses suggesting coincidence of malignant proliferative processes facilitates diagnostic and therapeutic procedures. We would like to present a case of Sweet's syndrome, qualified for comparative paraneoplastic skin syndromes. Sweet's syndrome, acute, febrile neutrophilic dermatosis, was first described by Robert Douglas Sweet in 1964 as a disorder characterized by fever, skin lesions of erythematous-infiltrative character, leukocytosis with neutrophilia and dense infiltrations of dermis by mature neutrophils. Sweet's syndrome aetiology is not fully understood, although cytokine abnormalities suggest that Th1 lymphocytes play an important role in pathogenesis of the dermatosis. Factors inducing Sweet's syndrome include: haematopoietic hyperplasia; neoplasms: genitourinary, breast, gastrointestinal; infections of the respiratory and alimentary system; inflammatory bowel diseases; drugs; pregnancy and vaccinations. Systemic corticosteroids are the "gold standard" of Sweet's syndrome treatment; potassium iodide or colchicine may also be used. Indomethacin, clofazimine, cyclosporine A and sulfones are the second-line drugs.
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland. Head of Department: Rafał Czajkowski MD, PhD.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kaszewski
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland. Head of Department: Rafał Czajkowski MD, PhD.
authors.forename: Rafał
authors.initials: R
authors.lastname: Czajkowski
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland. Head of Department: Rafał Czajkowski MD, PhD.
authors.forename: Franciszka
authors.initials: F
authors.lastname: Protas-Drozd
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland. Head of Department: Prof. Waldemar Placek MD, PhD.
authors.forename: Waldemar
authors.initials: W
authors.lastname: Placek
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland. Head of Department: Prof. Waldemar Placek MD, PhD.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Jakubowski
keywords: Sweet's syndrome; acute febrile; neutrophilic dermatosis; paraneoplasia; thrombocythemia