title: Diabetes. Cognitive decline and T2DM--a disconnect in the evidence?
abstract: Type 2 diabetes mellitus is associated with an increased risk of cognitive decline and dementia. Observational data suggest that hyperglycaemia, hypertension and dyslipidaemia might be involved in the causal pathway underlying this link, but data from the ACCORD MIND investigators challenge these findings. Why are the findings of observational and intervention studies so disconnected?
authors.affiliation: Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
authors.forename: Mark W J
authors.initials: MW
authors.lastname: Strachan
authors.affiliation: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
authors.forename: Jacqueline F
authors.initials: JF
authors.lastname: Price
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000523:psychology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D064887:Observational Studies as Topic
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents