title: [Cytomegalovirus mononucleosis complicated with peripheral facial palsy].
abstract: A 36-year-old woman was admitted to our hospital for further examination of an acute febrile illness with liver dysfunction. A peripheral blood smear displayed atypical lymphocytes. Cytomegalovirus (CMV) mononucleosis was diagnosed based on the detection of CMV-specific IgM and conventional CMV pp65 antigen. The physical examination on admission revealed signs of lower motor neuron right facial palsy. There were no significant cerebrospinal fluid findings, nor were there other neurological abnormalities. After receiving a short-course of oral corticosteroids, the patient gradually recovered from the facial paralysis. A one-month follow-up examination indicated that she had fully recovered neurologically, showing disappearance of CMV-DNA and a significant increase in the anti-CMV IgG titer. To our knowledge, there has been only one previous report describing CMV as the cause of an isolated facial palsy combined with CMV mononucleosis.
authors.affiliation: Department of Clinical Hematology and Oncology, Kumamoto City Hospital.
authors.forename: Taichi
authors.initials: T
authors.lastname: Hirano
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsuji
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuda
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000031:analogs & derivatives; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000008:administration & dosage; D015415:Biomarkers / Q000097:blood; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D005158:Facial Paralysis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007244:Infectious Mononucleosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D010750:Phosphoproteins / Q000097:blood; D011239:Prednisolone / Q000008:administration & dosage; D016896:Treatment Outcome; D000077483:Valacyclovir; D014633:Valine / Q000008:administration & dosage / Q000031:analogs & derivatives; D014763:Viral Matrix Proteins / Q000097:blood
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D015415:Biomarkers; D007075:Immunoglobulin M; D010750:Phosphoproteins; D014763:Viral Matrix Proteins; C065418:cytomegalovirus matrix protein 65kDa; D011239:Prednisolone; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir