title: Using positron emission tomography to study transporter-mediated drug-drug interactions in tissues.
abstract: Drug disposition is highly regulated by membrane transporters. Some transporter-mediated drug-drug interactions (DDIs) may not manifest themselves in changes in systemic exposure but rather in changes in tissue exposure of drugs. To better assess the impact of transporter-mediated DDIs in tissues, positron emission tomography (PET)-a noninvasive imaging method--plays an increasingly important role. In this article, we provide examples of how PET can be used to assess transporter-mediated DDIs in different organs.
authors.affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Wulkersdorfer
authors.affiliation: Health and Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
authors.forename: T
authors.initials: T
authors.lastname: Wanek
authors.affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Bauer
authors.affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Zeitlinger
authors.affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.affiliation: 1] Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria [2] Health and Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
authors.forename: O
authors.initials: O
authors.lastname: Langer
mesh_terms: D000818:Animals; D004347:Drug Interactions / Q000502:physiology*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods / Q000706:statistics & numerical data*; D014018:Tissue Distribution / Q000187:drug effects / Q000502:physiology
chemical_list: D026901:Membrane Transport Proteins; D004364:Pharmaceutical Preparations