title: Spirobisnaphthalenes from the mangrove-derived fungus Rhytidhysteron sp. AS21B.
abstract: Three new spirobisnaphthalenes (1-3) were isolated from the mangrove-derived fungus Rhytidhysteron sp., together with five known derivatives (4-8). The structures of the compounds were established on the basis of extensive spectroscopic data, and the relative configurations of their stereogenic carbons were determined by a single-crystal X-ray crystallographic analysis. Compounds 3-5 displayed cytotoxicity against both cancer cell lines, MCF-7 and CaSki, while 2 was active only on CaSKi cells.
authors.affiliation: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. khanitha.p@chula.ac.th.
authors.forename: Khanitha
authors.initials: K
authors.lastname: Pudhom
authors.affiliation: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. thapong_sthc@hotmail.com.
authors.forename: Thapong
authors.initials: T
authors.lastname: Teerawatananond
authors.affiliation: Program in Biotechnology, Faculty of Science, Chulalongkorn Universtiy, Bangkok 10330, Thailand. bubu_keaw@hotmail.com.
authors.forename: Supichar
authors.initials: S
authors.lastname: Chookpaiboon
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D025282:Mycelium / Q000737:chemistry; D009281:Naphthalenes / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D043982:Rhizophoraceae / Q000382:microbiology*; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
chemical_list: D000903:Antibiotics, Antineoplastic; D009281:Naphthalenes