title: [Scientific production on the applicability of phenytoin in wound healing].
abstract: Phenytoin is an anticonvulsant that has been used in wound healing. The objectives of this study were to describe how the scientific production presents the use ofphenytoinas a healing agent and to discuss its applicability in wounds. A literature review and hierarchy analysis of evidence-based practices was performed. Eighteen articles were analyzed that tested the intervention in wounds such as leprosy ulcers, leg ulcers, diabetic foot ulcers, pressure ulcers, trophic ulcers, war wounds, burns, preparation of recipient graft area, radiodermatitis and post-extraction of melanocytic nevi. Systemic use ofphenytoinin the treatment of fistulas and the hypothesis of topical use in the treatment of vitiligo were found. In conclusion, topical use ofphenytoinis scientifically evidenced. However robust research is needed that supports a protocol for the use ofphenytoinas another option of a healing agent in clinical practice.
authors.affiliation: National Cancer Institute, Rio de Janeiro, Brazil, flare_br@yahoo.com.br.
authors.forename: Flávia
authors.initials: F
authors.lastname: Firmino
authors.affiliation: Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: Alessandra Maria Pereira
authors.initials: AM
authors.lastname: de Almeida
authors.affiliation: Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: Rita de Jesus Grijó
authors.initials: Rde J
authors.lastname: e Silva
authors.affiliation: Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: Graziela da Silva
authors.initials: Gda S
authors.lastname: Alves
authors.affiliation: Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: Daniel da Silva
authors.initials: Dda S
authors.lastname: Grandeiro
authors.affiliation: Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: Lúcia Helena Garcia
authors.initials: LH
authors.lastname: Penna
mesh_terms: D006801:Humans; D010672:Phenytoin / Q000627:therapeutic use*; D011643:Publishing / Q000706:statistics & numerical data; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010672:Phenytoin