title: Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD.
abstract: Impulsivity is a multidimensional construct, including impulsive decision-making and impulsive action, representing relatively independent neurocircuitries. ADHD is treated with methylphenidate, a drug that binds to dopamine transporters. This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity.
authors.affiliation: Cleo L. Crunelle, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Belgium; Amsterdam Institute for Addiction Research and Departments of Psychiatry and Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands; Wim van den Brink, MD, PhD, Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands; Geert Dom, MD, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, and Psychiatric Centre Alexian Brothers, Boechout, Belgium; Jan Booij, MD, PhD, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
authors.forename: Cleo L
authors.initials: CL
authors.lastname: Crunelle
authors.affiliation: Cleo L. Crunelle, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Belgium; Amsterdam Institute for Addiction Research and Departments of Psychiatry and Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands; Wim van den Brink, MD, PhD, Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands; Geert Dom, MD, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, and Psychiatric Centre Alexian Brothers, Boechout, Belgium; Jan Booij, MD, PhD, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
authors.forename: Wim
authors.initials: W
authors.lastname: van den Brink
authors.affiliation: Cleo L. Crunelle, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Belgium; Amsterdam Institute for Addiction Research and Departments of Psychiatry and Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands; Wim van den Brink, MD, PhD, Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands; Geert Dom, MD, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, and Psychiatric Centre Alexian Brothers, Boechout, Belgium; Jan Booij, MD, PhD, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
authors.forename: Geert
authors.initials: G
authors.lastname: Dom
authors.affiliation: Cleo L. Crunelle, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Belgium; Amsterdam Institute for Addiction Research and Departments of Psychiatry and Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands; Wim van den Brink, MD, PhD, Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands; Geert Dom, MD, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, and Psychiatric Centre Alexian Brothers, Boechout, Belgium; Jan Booij, MD, PhD, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: Booij
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000187:drug effects*; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use; D006801:Humans; D007175:Impulsive Behavior / Q000187:drug effects*; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D008774:Methylphenidate