title: The role of surface functionality in nanoparticle exocytosis.
abstract: Getting out is just as important for nano-therapeutics as getting in. Exocytosis rates determine residency time in the cell, an important determinant for therapeutic efficacy and also for eventual clearance from the cell. In this study, it is shown that exocytosis efficiency is determined by surface functionality, providing a strategy for optimizing nanocarriers.
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Kim
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
authors.forename: Ngoc D B
authors.initials: NDB
authors.lastname: Le
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
authors.forename: Bo
authors.initials: B
authors.lastname: Yan
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
authors.forename: Gulen Yesilbag
authors.initials: GY
authors.lastname: Tonga
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
authors.forename: Chaekyu
authors.initials: C
authors.lastname: Kim
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
authors.forename: Richard W
authors.initials: RW
authors.lastname: Vachet
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D005089:Exocytosis; D006046:Gold / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D006046:Gold
keywords: exocytosis; gold nanoparticle; inductively coupled plasma mass spectrometry; surface functionality