title: The Geogenomic Mutational Atlas of Pathogens (GoMAP) web system.
abstract: We present a new approach for pathogen surveillance we call Geogenomics. Geogenomics examines the geographic distribution of the genomes of pathogens, with a particular emphasis on those mutations that give rise to drug resistance. We engineered a new web system called Geogenomic Mutational Atlas of Pathogens (GoMAP) that enables investigation of the global distribution of individual drug resistance mutations. As a test case we examined mutations associated with HIV resistance to FDA-approved antiretroviral drugs. GoMAP-HIV makes use of existing public drug resistance and HIV protein sequence data to examine the distribution of 872 drug resistance mutations in ∼ 502,000 sequences for many countries in the world. We also implemented a broadened classification scheme for HIV drug resistance mutations. Several patterns for geographic distributions of resistance mutations were identified by visual mining using this web tool. GoMAP-HIV is an open access web application available at http://www.bio-toolkit.com/GoMap/project/
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: David P
authors.initials: DP
authors.lastname: Sargeant
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Hedden
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Deverasetty
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Christy L
authors.initials: CL
authors.lastname: Strong
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Izua J
authors.initials: IJ
authors.lastname: Alaniz
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Alexandria N
authors.initials: AN
authors.lastname: Bartlett
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Brandon
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Steven B
authors.initials: SB
authors.lastname: Brooks
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Brown
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Flaviona
authors.initials: F
authors.lastname: Bufi
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Monika
authors.initials: M
authors.lastname: Chakarova
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Roxanne P
authors.initials: RP
authors.lastname: David
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Karlyn M
authors.initials: KM
authors.lastname: Dobritch
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Horacio P
authors.initials: HP
authors.lastname: Guerra
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Kelvy S
authors.initials: KS
authors.lastname: Levit
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Kiran R
authors.initials: KR
authors.lastname: Mathew
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Ray
authors.initials: R
authors.lastname: Matti
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Dorothea Q
authors.initials: DQ
authors.lastname: Maza
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Sabyasachy
authors.initials: S
authors.lastname: Mistry
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Nemanja
authors.initials: N
authors.lastname: Novakovic
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Austin
authors.initials: A
authors.lastname: Pomerantz
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Rafalski
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Viraj
authors.initials: V
authors.lastname: Rathnayake
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Noura
authors.initials: N
authors.lastname: Rezapour
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Ross
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Steve G
authors.initials: SG
authors.lastname: Schooler
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Sarah
authors.initials: S
authors.lastname: Songao
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Sean L
authors.initials: SL
authors.lastname: Tuggle
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Helen J
authors.initials: HJ
authors.lastname: Wing
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Sandy
authors.initials: S
authors.lastname: Yousif
authors.affiliation: School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Schiller
mesh_terms: D003141:Communicable Diseases / Q000209:etiology*; D030541:Databases, Genetic; D064349:Genome, Microbial; D023281:Genomics / Q000379:methods*; D005843:Geography; D014943:Global Health; D015658:HIV Infections; D006801:Humans; D009154:Mutation; D011159:Population Surveillance / Q000379:methods*; D064878:Web Browser