title: Psychiatric disorders: diagnosis to therapy.
abstract: Recent findings in a range of scientific disciplines are challenging the conventional wisdom regarding the etiology, classification, and treatment of psychiatric disorders. This Review focuses on the current state of the psychiatric diagnostic nosology and recent progress in three areas: genomics, neuroimaging, and therapeutics development. The accelerating pace of novel and unexpected findings is transforming the understanding of mental illness and represents a hopeful sign that the approaches and models that have sustained the field for the past 40 years are yielding to a flood of new data and presaging the emergence of a new and more powerful scientific paradigm.
authors.affiliation: Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA; VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT 06516, USA. Electronic address: john.krystal@yale.edu.
authors.forename: John H
authors.initials: JH
authors.lastname: Krystal
authors.affiliation: Department of Psychiatry and Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: matthew.state@ucsf.edu.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: State
mesh_terms: D000818:Animals; D006801:Humans; D001523:Mental Disorders / Q000145:classification / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D059906:Neuroimaging; D009488:Neurosciences / Q000379:methods*