title: Single nucleotide polymorphisms of microRNA processing machinery genes and outcome of hepatocellular carcinoma.
abstract: MicroRNA (miRNA)-related single nucleotide polymorphisms (miR-SNPs) can affect cancer development, treatment efficacy and patients prognosis. We examined 6 miR-SNPs in miRNA processing machinery genes including exportin 5 (XPO5) (rs11077), Ran-GTPase (RAN) (rs14035), Dicer (rs3742330), Trinucleotide Repeat Containing 6B (TNRC6B) (rs9623117), GEMIN3 (rs197412), GEMIN4 (rs2740348) in 108 surgically resected HCC patients and evaluated the impact of these miR-SNPs on HCC outcome. Among the 6 SNPs, only the A/A genotype of rs11077 located in XPO5 3'UTR was identified to associated independently with worse survival in HCC patients by multivariate analysis with relative risk, 0.395; 95% CI, 0.167-0.933; p = 0.034. This is the first study reporting that polymorphisms related to miRSNPs have prognostic value in hepatocellular carcinoma and identify the A/A genotype of rs11077 SNP site located in XPO5 3'UTR can help to predict worse prognosis in patients.
authors.affiliation: Department of Pathology, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Pathology, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Jie
authors.initials: J
authors.lastname: An
authors.affiliation: Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Pathology, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.
authors.forename: Lidao
authors.initials: L
authors.lastname: Bao
authors.affiliation: Department of Pathology, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D028884:Karyopherins / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D063868:Patient Outcome Assessment; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis
chemical_list: D028884:Karyopherins; D035683:MicroRNAs; C446511:XPO5 protein, human