title: Prevalence and outcome of non-alcoholic fatty liver disease in adolescents and young adults undergoing weight loss surgery.
abstract: OBJECTIVE
  We evaluated the prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in 27 adolescents referred for weight loss surgery (WLS).
  
  
  RESULTS
  On biopsy, 18 patients (66.7%) had NAFLD, and of those, 10 (37.0%) had NASH and 11 (40.7%) had fibrosis. Insulin, HbA1C and homeostatic model assessment of insulin resistance (HOMA-IR) were significantly higher in patients with NASH than those without NASH. Following WLS, 40% of patients with NASH had persistently elevated aminotransferase levels despite weight loss.
  
  
  CONCLUSIONS
  We found that NASH is underdiagnosed in adolescents referred for WLS, and that hyperinsulinaemia, HOMA-IR and HbA1c can aid in identifying high-risk patients.
authors.affiliation: Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Weight Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Corey
authors.forename: T L
authors.initials: TL
authors.lastname: Stanley
authors.forename: J
authors.initials: J
authors.lastname: Misdraji
authors.forename: C
authors.initials: C
authors.lastname: Scirica
authors.forename: J
authors.initials: J
authors.lastname: Pratt
authors.forename: A
authors.initials: A
authors.lastname: Hoppin
authors.forename: M
authors.initials: M
authors.lastname: Misra
mesh_terms: D000293:Adolescent; D000328:Adult; D050110:Bariatric Surgery / Q000379:methods*; D015415:Biomarkers / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D008099:Liver / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000453:epidemiology / Q000473:pathology*; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D000637:Transaminases / Q000378:metabolism; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; D000637:Transaminases; C517652:hemoglobin A1c protein, human
keywords: Adolescence; Roux-en-Y gastric bypass; non-alcoholic fatty liver disease; obesity