title: Two new antibiotic pyridones produced by a marine fungus, Trichoderma sp. strain MF106.
abstract: Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC₅₀ values of 24 μM and 4 μM, respectively.
authors.affiliation: Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany. wubin@zju.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.affiliation: Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany. vlutz@geomar.de.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Oesker
authors.affiliation: Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany. jwiese@geomar.de.
authors.forename: Jutta
authors.initials: J
authors.lastname: Wiese
authors.affiliation: Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany. rschmaljohann@geomar.de.
authors.forename: Rolf
authors.initials: R
authors.lastname: Schmaljohann
authors.affiliation: Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany. jimhoff@geomar.de.
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D001267:Atlantic Ocean; D001419:Bacteria / Q000187:drug effects; D001578:Benzopyrans / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D045744:Cell Line, Tumor; D003470:Culture Media; D003500:Cyclization; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D025282:Mycelium / Q000378:metabolism; D011728:Pyridones / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D012623:Seawater / Q000382:microbiology; D013212:Staphylococcus epidermidis / Q000187:drug effects; D014242:Trichoderma / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D003470:Culture Media; D011728:Pyridones; C000592879:trichodin A