title: Conical scan polarization-sensitive optical coherence tomography.
abstract: We report on a new articular cartilage imaging technique with potential for clinical arthroscopic use, by supplementing the variable-incidence-angle polarization-sensitive optical coherence tomography method previously developed by us with a conical beam scan protocol. The technique is validated on bovine tendon by comparing experimental data with simulated data generated using the extended Jones matrix calculus. A unique capability of this new optical technique is that it can locate the "brushing direction" of collagen fibers in articular cartilage, which is structural information that extends beyond established methods such as split-line photography or birefringent fast-axis measurement in that it is uniquely defined over the full azimuthal-angle range of (-π, + π). The mapping of this direction over the cartilage surface may offer insights into the optimal design of tissue-engineering scaffolds for cartilage repair.
authors.affiliation: Department of Materials Science and Engineering, the Kroto Research Institute, University of Sheffield, North Campus, Broad Lane, Sheffield, S3 7HQ, UK ; Department of Electronic and Electrical Engineering, University of Sheffield, Mappin Street, Sheffield, S1 3JD, UK.
authors.forename: Zenghai
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Materials Science and Engineering, the Kroto Research Institute, University of Sheffield, North Campus, Broad Lane, Sheffield, S3 7HQ, UK ; Currently with the Computational Optics Group, University of Tsukuba, Tsukuba, Japan.
authors.forename: Deepa
authors.initials: D
authors.lastname: Kasaragod
authors.affiliation: Department of Materials Science and Engineering, the Kroto Research Institute, University of Sheffield, North Campus, Broad Lane, Sheffield, S3 7HQ, UK.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Matcher
keywords: (170.3880) Medical and biological imaging; (170.3890) Medical optics instrumentation; (170.4500) Optical coherence tomography; (260.1440) Birefringence; (260.5430) Polarization