title: Red Si-rhodamine drug conjugates enable imaging in GFP cells.
abstract: Here we evaluated a series of Si-derivatized rhodamine (SiR) dyes for their ability to visualize a model drug in live cells. We show that a charge neutral SiR derivative (but not others) can indeed be used to follow the intracellular location of the model therapeutic drug in GFP cells.
authors.affiliation: Center for Systems Biology, Massachusettes General Hospital/Harvard Medical School, 185 Cambridge St, Boston, MA 02114, USA. rweissleder@mgh.harvard.edu.
authors.forename: Eunha
authors.initials: E
authors.lastname: Kim
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Yang
authors.forename: Randy J
authors.initials: RJ
authors.lastname: Giedt
authors.forename: Ralph
authors.initials: R
authors.lastname: Weissleder
mesh_terms: D045744:Cell Line, Tumor; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D018613:Microscopy, Confocal; D010793:Phthalazines / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry*
chemical_list: D010793:Phthalazines; D010879:Piperazines; D012235:Rhodamines; D049452:Green Fluorescent Proteins; C531550:olaparib; D012825:Silicon