title: Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats.
abstract: We aimed at investigating the effect of honokiol on heatstroke in an experimental rat model. Sprogue-Dawley rats were divided into 3 groups: normothermic diabetic rats treated with vehicle solution (NTDR+V), heatstroke-diabetic rats treated with vehicle (HSDR+V), and heatstroke rats treated with konokiol (0.5-5 mg/ml/kg) (HSDR+H). Sixty minutes before the start of heat stress, honokiol or vehicle solution was administered. (HSDR+H) significantly (a) attenuated hyperthermia, hypotension and hypothalamic ischemia, hypoxia, and neuronal apoptosis; (b) reduced the plasma index of the toxic oxidizing radicals; (c) diminished the indices of hepatic and renal dysfunction; (d) attenuated the plasma systemic inflammatory response molecules; (e) promoted plasma levels of an anti-inflammatory cytokine; (f) reduced the index of infiltration of polymorphonuclear neutrophils in the serum; and (g) promoted the survival time fourfold compared with the (HSDR+V) group. In conclusion, honokiol protected against the outcome of heatstroke by reducing inflammation and oxidative stress-mediated multiple organ dysfunction in diabetic rats.
authors.affiliation: Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 112, Taiwan ; Division of Cardiovascular Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei 112, Taiwan.
authors.forename: Chuan-Chih
authors.initials: CC
authors.lastname: Hsu
authors.affiliation: Nursing Department, Cheng Kung University Hospital, Tainan 701, Taiwan ; Department of Nursing, Chang Jung Christian University, Tainan 712, Taiwan.
authors.forename: Li-Fan
authors.initials: LF
authors.lastname: Chen
authors.affiliation: Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan.
authors.forename: Mao-Tsun
authors.initials: MT
authors.lastname: Lin
authors.affiliation: Department of Surgery, Chi Mei Medical Center, Tainan 710, Taiwan ; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 712, Taiwan.
authors.forename: Yu-Feng
authors.identifier: 0000-0002-5607-7088
authors.initials: YF
authors.lastname: Tian