title: Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart.
abstract: The role of resveratrol (Res) in inflammation induced by ischemia/reperfusion is not well understood. The aim of the present study was to investigate whether Res modulates neutrophil accumulation and tumor necrosis factor-α (TNF-α) induction in an ischemia/reperfusion-injured rat heart model. The rats were randomly exposed to sham surgery, myocardial ischemia/reperfusion (MI/R) alone, MI/R + Res, MI/R + Res + L-NG-nitroarginine methyl ester (L-NAME) and MI/R + Res + methylene blue (MB). The results demonstrated that compared with MI/R, Res reduced the myocardial infarct area, myocardial myeloperoxidase levels, serum creatinine kinase and lactate dehydrogenase levels, and serum and myocardial TNF-α production. All the effects of Res demonstrated were inhibited by L-NAME (a nitric oxide (NO) synthase inhibitor) and MB [a cyclic guanosine monophosphate (cGMP) inhibitor]. Thus, Res produces cardioprotective and anti-inflammatory effects. These effects may be associated with an increase in NO production, the inhibition of neutrophil accumulation, TNF-α induction and cGMP signaling pathways in myocardium subjected to MI/R.
authors.affiliation: Department of Cardiology, Bethune First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Cong
authors.affiliation: Department of Emergency Internal Medicine, The People's Hospital of Jilin Province, Changchun, Jilin 130021, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Cardiology, Bethune First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Lu
authors.affiliation: Department of Internal Medicine, The Friendship Hospital of Linjiang, Linjiang, Jilin 134600, P.R. China.
authors.forename: Yajian
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Internal Medicine, The Friendship Hospital of Linjiang, Linjiang, Jilin 134600, P.R. China.
authors.forename: Huijie
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Bethune First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Nutrition and Toxicology, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D015428:Myocardial Reperfusion Injury / Q000150:complications* / Q000378:metabolism; D020556:Neutrophil Infiltration / Q000187:drug effects; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013267:Stilbenes; D014409:Tumor Necrosis Factor-alpha; D003402:Creatine Kinase; D000077185:Resveratrol