title: Cost-effectiveness analysis of pneumococcal conjugate vaccine 13-valent in older adults in Colombia.
abstract: BACKGROUND
  Nowadays, there are two vaccination strategies in Colombia to prevent pneumococcal diseases in people over 50 years. Our aim is to estimate cost-effectiveness of pneumococcal conjugate vaccine 13-valent (PCV13) versus pneumococcal polysaccharide vaccine 23-valent (PPSV23) to prevent pneumococcal diseases and their related mortality in people over 50 years old in Colombia.
  
  
  METHODS
  A Markov model was developed with national data, including pneumococcal serotypes distribution in Colombia between 2005 and 2010. Vaccination of a cohort was simulated and a five year time horizon was assumed. Analysis was done from a perspective of a third party payer. Direct costs were provided by a national insurance company; sensitive univariate and probabilistic analysis were done for epidemiological and clinical effectiveness parameters and costs.
  
  
  RESULTS
  PCV13 avoids 3 560 deaths by pneumococcal infections versus PPSV23 and 4 255 deaths versus no vaccine. PCV13 prevents 79 633 cases by all-cause pneumonia versus PPSV23 and 81 468 cases versus no vaccine. Total costs (healthcare and vaccines costs) with PCV13 would be U.S. $ 97,587,113 cheaper than PPSV23 and it would save U.S. $ 145,196,578 versus no vaccine.
  
  
  CONCLUSIONS
  PCV13 would be a cost-saving strategy in the context of a mass vaccination program in Colombia to people over 50 years old because it would reduce burden of disease and specific mortality by pneumococcal diseases, besides, it saves money versus PPSV23.
authors.affiliation: HEMO Group, Carrera 25 A # 1 A Sur-45, piso 5, Medellín, Colombia. gerencia@hemogroup.com.co.
authors.forename: Jaime E
authors.initials: JE
authors.lastname: Ordóñez
authors.forename: John J
authors.initials: JJ
authors.lastname: Orozco
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003105:Colombia / Q000453:epidemiology; D003362:Cost-Benefit Analysis; D006801:Humans; D008390:Markov Chains; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000191:economics* / Q000453:epidemiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000191:economics*; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: C538862:13-valent pneumococcal vaccine; D022242:Pneumococcal Vaccines