title: Clearance of Pneumocystis murina infection is not dependent on MyD88.
abstract: To determine if myeloid differentiation factor 88 (MyD88), which is necessary for signaling by most TLRs and IL-1Rs, is necessary for control of Pneumocystis infection, MyD88-deficient and wild-type mice were infected with Pneumocystis by exposure to infected seeder mice and were followed for up to 106 days. MyD88-deficient mice showed clearance of Pneumocystis and development of anti-Pneumocystis antibody responses with kinetics similar to wild-type mice. Based on expression levels of select genes, MyD88-deficient mice developed immune responses similar to wild-type mice. Thus, MyD88 and the upstream pathways that rely on MyD88 signaling are not required for control of Pneumocystis infection.
authors.affiliation: Critical Care Medicine Department, NIH Clinical Center, NIH, Building 10, Room 2C145, MSC 1662, Bethesda, MD 20892-1662, USA.
authors.forename: Chiara
authors.initials: C
authors.lastname: Ripamonti
authors.affiliation: Critical Care Medicine Department, NIH Clinical Center, NIH, Building 10, Room 2C145, MSC 1662, Bethesda, MD 20892-1662, USA.
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Bishop
authors.affiliation: Laboratory of Immunopathogenesis and Bioinformatics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Laboratory of Immunopathogenesis and Bioinformatics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Lempicki
authors.affiliation: Critical Care Medicine Department, NIH Clinical Center, NIH, Building 10, Room 2C145, MSC 1662, Bethesda, MD 20892-1662, USA. Electronic address: jkovacs@mail.nih.gov.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Kovacs
mesh_terms: D000818:Animals; D051379:Mice; D008810:Mice, Inbred C57BL; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D011010:Pneumocystis / Q000472:pathogenicity*; D016720:Pneumocystis Infections / Q000235:genetics / Q000276:immunology*; D017472:Receptors, Interleukin-1 / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D053594:Myeloid Differentiation Factor 88; D017472:Receptors, Interleukin-1
keywords: Innate immunity; MyD88; PCP; Pneumocystis; TLR