title: Point decoration of silicon nanowires: an approach toward single-molecule electrical detection.
abstract: Probing interactions of biological systems at the molecular level is of great importance to fundamental biology, diagnosis, and drug discovery. A rational bioassay design of lithographically integrating individual point scattering sites into electrical circuits is capable of realizing real-time, label-free biodetection of influenza H1N1 viruses with single-molecule sensitivity and high selectivity by using silicon nanowires as local reporters in combination with microfluidics. This nanocircuit-based architecture is complementary to more conventional optical techniques, but has the advantages of no bleaching problems and no fluorescent labeling. These advantages offer a promising platform for exploring dynamics of stochastic processes in biological systems and gaining information from genomics to proteomics to improve accurate molecular and even point-of-care clinical diagnosis.
authors.affiliation: School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (P. R. China).
authors.forename: Jindong
authors.initials: J
authors.lastname: Wang
authors.forename: Fangxia
authors.initials: F
authors.lastname: Shen
authors.forename: Zhenxing
authors.initials: Z
authors.lastname: Wang
authors.forename: Gen
authors.initials: G
authors.lastname: He
authors.forename: Jinwen
authors.initials: J
authors.lastname: Qin
authors.forename: Nongyi
authors.initials: N
authors.lastname: Cheng
authors.forename: Maosheng
authors.initials: M
authors.lastname: Yao
authors.forename: Lidong
authors.initials: L
authors.lastname: Li
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Guo
mesh_terms: D004560:Electricity; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D053770:Nanowires; D012825:Silicon / Q000737:chemistry*
chemical_list: D012825:Silicon
keywords: H1N1 antibody; biosensors; point decoration; silicon nanowires; single-molecule studies