title: Differences in pancreatic volume, fat content, and fat density measured by multidetector-row computed tomography according to the duration of diabetes.
abstract: Pancreatic volume and fat content might be associated with β-cell function or insulin resistance (IR). We investigated the difference in pancreatic volume and fat content between age- and body mass index (BMI)-matched normal subjects and patients with having different durations of type 2 diabetes (T2D). We compared pancreatic volume and fat parameters between 50 age- and BMI-matched normal subjects, 51 subjects with newly diagnosed type 2 diabetes (T2D-new), 53 subjects with T2D <5 years (T2D<5Y), and 52 subjects with T2D ≥5 years (T2D≥5Y). Age and BMI were matched to range of ±2 years and ±0.5 kg/m(2), respectively. Pancreatic volume and fat were measured by multidetector-row computed tomography with 64 detector-row scanner. The difference in Hounsfield units between pancreas and spleen (HUp-s) was investigated for fat density. Anthropometric and biochemical parameters including the homeostasis model assessment of IR (HOMA-IR) and the insulinogenic index (IGI) were measured. Compared with normal subjects, patients with T2D had significantly smaller pancreatic volume, greater pancreatic fat, and lower HUp-s. Among the groups with T2D, pancreatic volume decreased and pancreatic fat percentage and HUp-s increased from the T2D-new to the T2D<5Y and T2D>5Y groups. Pancreatic volume and fat and HUp-s values were associated with HbA1c and triglyceride levels. Pancreatic volume was correlated with IGI while pancreatic fat and HUp-s values were correlated with HOMA-IR. The current study suggests that pancreatic volume and fat deposition might be associated with the development and progression of T2D in Korean subjects.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Soo
authors.initials: S
authors.lastname: Lim
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Bae
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Chun
authors.forename: Haeryoung
authors.initials: H
authors.lastname: Kim
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Kim
authors.forename: Kyoung Min
authors.initials: KM
authors.lastname: Kim
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Choi
authors.forename: Kyong Soo
authors.initials: KS
authors.lastname: Park
authors.forename: Jose C
authors.initials: JC
authors.lastname: Florez
authors.forename: Hak Chul
authors.initials: HC
authors.lastname: Jang
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D005223:Fats / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D061330:Multidetector Computed Tomography; D009929:Organ Size; D010179:Pancreas / Q000737:chemistry / Q000000981:diagnostic imaging / Q000254:growth & development* / Q000378:metabolism; D013997:Time Factors
chemical_list: D005223:Fats