title: PBSC vs BM grafts with myeloablative conditioning for unrelated donor transplantation in adults with high-risk ALL.
abstract: Few studies are available that compare PBSC and BM from unrelated donors, especially in adult high-risk ALL. To determine which graft source is superior in adult high-risk ALL, we analyzed the long-term outcomes of 106 consecutive transplants from 8/8-matched or 7/8-matched unrelated donors (38 PBSC vs 68 BM). All patients received a uniform strategy of pre-transplant therapy, myeloablative conditioning and GVHD prophylaxis. At 5 years, PBSC transplants showed higher incidence of chronic GVHD than did BM transplants (74.3% vs 46.7%, P=0.001). PBSC transplants showed outcomes comparable to those of BM transplants for relapse (23.7% vs 28.1%), non-relapse mortality (18.4% vs 25.0%), disease-free survival (57.9% vs 46.9%) and OS (57.9% vs 50.0%). In a separate comparison of outcomes between the two graft sources according to the presence of a Ph chromosome, no significant advantage of PBSC over BM was found in both subgroups of patients. Our data suggest that the outcomes of unrelated donor transplantation are similar between PBSC and BM in adult high-risk ALL. Whether PBSC should be the preferred graft source for a specific subgroup of adult ALL needs to be further investigated.
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: S-H
authors.initials: SH
authors.lastname: Shin
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: J-H
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: S-A
authors.initials: SA
authors.lastname: Yahng
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: S-E
authors.initials: SE
authors.lastname: Lee
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: B-S
authors.initials: BS
authors.lastname: Cho
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: K-S
authors.initials: KS
authors.lastname: Eom
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: C-K
authors.initials: CK
authors.lastname: Min
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: S-G
authors.initials: SG
authors.lastname: Cho
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: D-W
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: J-W
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: W-S
authors.initials: WS
authors.lastname: Min
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: C-W
authors.initials: CW
authors.lastname: Park
authors.affiliation: Department of Hematology, Catholic BMT Center, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: S
authors.initials: S
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D018572:Disease-Free Survival; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D019653:Myeloablative Agonists / Q000627:therapeutic use; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D013812:Therapeutics; D019172:Transplantation Conditioning; D061349:Unrelated Donors; D055815:Young Adult
chemical_list: D019653:Myeloablative Agonists