title: Carrier-based drug delivery system for treatment of acne.
abstract: Approximately 95% of the population suffers at some point in their lifetime from acne vulgaris. Acne is a multifactorial disease of the pilosebaceous unit. This inflammatory skin disorder is most common in adolescents but also affects neonates, prepubescent children, and adults. Topical conventional systems are associated with various side effects. Novel drug delivery systems have been used to reduce the side effect of drugs commonly used in the topical treatment of acne. Topical treatment of acne with active pharmaceutical ingredients (API) makes direct contact with the target site before entering the systemic circulation which reduces the systemic side effect of the parenteral or oral administration of drug. The objective of the present review is to discuss the conventional delivery systems available for acne, their drawbacks, and limitations. The advantages, disadvantages, and outcome of using various carrier-based delivery systems like liposomes, niosomes, solid lipid nanoparticles, and so forth, are explained. This paper emphasizes approaches to overcome the drawbacks and limitations associated with the conventional system and the advances and application that are poised to further enhance the efficacy of topical acne formulations, offering the possibility of simplified dosing regimen that may improve treatment outcomes using novel delivery system.
authors.affiliation: University Institute of Pharmacy, Pandit Ravishankar Shukla University, Raipur 492 010, India.
authors.forename: Amber
authors.initials: A
authors.lastname: Vyas
authors.affiliation: University Institute of Pharmacy, Pandit Ravishankar Shukla University, Raipur 492 010, India.
authors.forename: Avinesh
authors.initials: A
authors.lastname: Kumar Sonker
authors.affiliation: University Institute of Pharmacy, Pandit Ravishankar Shukla University, Raipur 492 010, India.
authors.forename: Bina
authors.identifier: 0000-0003-1257-723X
authors.initials: B
authors.lastname: Gidwani
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D006801:Humans
chemical_list: D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D004337:Drug Carriers