title: Immunologic status and virologic outcomes in repeat pregnancies to HIV-positive women not on antiretroviral therapy at conception: a case for lifelong antiretroviral therapy?
abstract: During their second pregnancy with diagnosed HIV (n = 1177), two-fifths of women in the UK/Ireland not on antiretroviral therapy (ART) at conception had an immunological indication for treatment (CD4(+) <350 cells/μl), of whom nearly half had CD4(+) at least 350 cells/μl in their previous pregnancy. Those initiating ART during pregnancy had a 4.3-fold increased odds of detectable viral load at delivery compared with those conceiving on treatment, suggesting that continuation of ART after pregnancy may be beneficial for many women.
authors.affiliation: aPopulation, Policy and Practice Programme, UCL Institute of Child Health, University College London, UK bSchool of Health Sciences, City University London, UK.
authors.forename: Clare E
authors.initials: CE
authors.lastname: French
authors.forename: Claire
authors.initials: C
authors.lastname: Thorne
authors.forename: Shema
authors.initials: S
authors.lastname: Tariq
authors.forename: Mario
authors.initials: M
authors.lastname: Cortina-Borja
authors.forename: Pat A
authors.initials: PA
authors.lastname: Tookey
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D007494:Ireland; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000821:virology*; D016896:Treatment Outcome; D006113:United Kingdom
chemical_list: D044966:Anti-Retroviral Agents