title: Whisker barrel cortex delta oscillations and gamma power in the awake mouse are linked to respiration.
abstract: Current evidence suggests that delta oscillations (0.5-4 Hz) in the brain are generated by intrinsic network mechanisms involving cortical and thalamic circuits. Here we report that delta band oscillation in spike and local field potential (LFP) activity in the whisker barrel cortex of awake mice is phase locked to respiration. Furthermore, LFP oscillations in the gamma frequency band (30-80 Hz) are amplitude modulated in phase with the respiratory rhythm. Removal of the olfactory bulb eliminates respiration-locked delta oscillations and delta-gamma phase-amplitude coupling. Our findings thus suggest respiration-locked olfactory bulb activity as a main driving force behind delta oscillations and gamma power modulation in the whisker barrel cortex in the awake state.
authors.affiliation: 1] Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6), Jülich Research Centre and JARA, Building 15.22, 52425 Jülich, Germany [2].
authors.forename: J
authors.initials: J
authors.lastname: Ito
authors.affiliation: 1] Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Ave, Memphis, Tennessee 38163, USA [2].
authors.forename: S
authors.initials: S
authors.lastname: Roy
authors.affiliation: 1] Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Ave, Memphis, Tennessee 38163, USA [2].
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Ave, Memphis, Tennessee 38163, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Ave, Memphis, Tennessee 38163, USA.
authors.forename: M
authors.initials: M
authors.lastname: Fletcher
authors.affiliation: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Ave, Memphis, Tennessee 38163, USA.
authors.forename: L
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Ave, Memphis, Tennessee 38163, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Boughter
authors.affiliation: 1] Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6), Jülich Research Centre and JARA, Building 15.22, 52425 Jülich, Germany [2] Theoretical Systems Neurobiology, Institute for Biology II, RWTH Aachen University, 52056 Aachen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Grün
authors.affiliation: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Ave, Memphis, Tennessee 38163, USA.
authors.forename: D H
authors.initials: DH
authors.lastname: Heck
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000737:chemistry / Q000502:physiology*; D004569:Electroencephalography; D008297:Male; D051379:Mice / Q000502:physiology* / Q000523:psychology; D008810:Mice, Inbred C57BL; D009830:Olfactory Bulb / Q000737:chemistry / Q000502:physiology*; D012119:Respiration; D014738:Vibrissae / Q000502:physiology*; D014851:Wakefulness