title: [Post-training N-methyl-D-aspartate receptor blockade facilitates retention of acquired spatial memory in rats].
abstract: We investigated the effect of a post-training chronic infusion of N-methyl-D-aspartate (NMDA) receptor blocker on retention of spatial reference memory in rats. In Experiment 1, we trained 4 groups of rats for 4 days (4 trials/ day) in the Morris water maze task. In a single probe trial after retention intervals of 1, 7, 14, and 28 days, the 1-day group showed more goal crossings than shown by the other 3 groups. In Experiment 2, a chronic infusion of the NMDA receptor antagonist D-2-amino-5-phosphonovaleric acid (D-AP5) or a control vehicle into the lateral ventricle was initiated 1 day after the training session, and continued for 6 days. In the subsequent probe trial (7 days after training), the rats that had received the D-AP5 infusion showed significantly more goal crossings than the controls. These findings suggest that an NMDA receptor blockade following acquisition facilitates retention of spatial reference memory.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Shinohara
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Hata
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000818:Animals; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000502:physiology; D012153:Retention, Psychology / Q000187:drug effects*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate