title: IGF-1 colocalizes with muscle satellite cells following acute exercise in humans.
abstract: Insulin-like growth factor-1 (IGF-1) regulates stem cell proliferation and differentiation in vitro. The aim of this study was to quantify the change in satellite cell (SC) specific IGF-1 colocalization following exercise. We observed a significant increase (p < 0.05) in the percentage of SC with IGF-1 colocalization from baseline to 72 h after a bout of resistance exercise. This strongly supports a role for IGF-1 in human SC function following exercise.
authors.affiliation: a Department of Kinesiology, McMaster University, Hamilton, ON L8S 4L8, Canada.
authors.forename: Amanda
authors.initials: A
authors.lastname: Grubb
authors.forename: Sophie
authors.initials: S
authors.lastname: Joanisse
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Moore
authors.forename: Leeann M
authors.initials: LM
authors.lastname: Bellamy
authors.forename: Cameron J
authors.initials: CJ
authors.lastname: Mitchell
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Phillips
authors.forename: Gianni
authors.initials: G
authors.lastname: Parise
mesh_terms: D000293:Adolescent; D000328:Adult; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism*; D008297:Male; D032496:Satellite Cells, Skeletal Muscle / Q000737:chemistry / Q000378:metabolism*; D055815:Young Adult
chemical_list: D007334:Insulin-Like Growth Factor I