title: Nanoengineered particles for enhanced intra-articular retention and delivery of proteins.
abstract: Localized intra-articular delivery of anti-inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self-assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra-articular joint spaces compared to bolus protein over a period of 14 d.
authors.affiliation: Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA; Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853, USA.
authors.forename: Ankur
authors.initials: A
authors.lastname: Singh
authors.forename: Rachit
authors.initials: R
authors.lastname: Agarwal
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Diaz-Ruiz
authors.forename: Nick J
authors.initials: NJ
authors.lastname: Willett
authors.forename: Peiyi
authors.initials: P
authors.lastname: Wang
authors.forename: L Andrew
authors.initials: LA
authors.lastname: Lee
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Robert E
authors.initials: RE
authors.lastname: Guldberg
authors.forename: Andrés J
authors.initials: AJ
authors.lastname: García
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D002460:Cell Line; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D005353:Fibronectins / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D010316:Particle Size; D011102:Polyhydroxyethyl Methacrylate / Q000008:administration & dosage / Q000737:chemistry; D011506:Proteins / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D011917:Rats, Inbred Lew; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000893:Anti-Inflammatory Agents; D004337:Drug Carriers; D005353:Fibronectins; D011506:Proteins; D011102:Polyhydroxyethyl Methacrylate; D012710:Serum Albumin, Bovine
keywords: biomaterials; nanoparticles; osteoarthritis; protein delivery