title: [Clinical observation of intra-operative PTH assay in hyperparathyroidism due to parathyroid tumors].
abstract: OBJECTIVE
  To investigate the clinical manifestations and diagnostic method of hyperparathyroidism due to parathyroid tumors and to evaluate the intra-operative detection of parathyroid hormone in surgical treatment.
  
  
  METHODS
  Thirty-seven cases with functional parathyroid tumors from January 2003 to October 2012 were retrospectively analyzed. The clinical manifestation, examination and operation method, changes of parathyroid hormone before and after operation were collected.
  
  
  RESULTS
  All cases were definitely diagnosed before operation. The sensitivity and the positively predictive values of neck ultrasonography were 86.5% and 97.6% respectively, and the same data of Tc-99m-MIBI was 97.2% and 100.0%. The PTH levels declined by 84.9% ten minutes after tumor resecting compared with the level before operation. The serum calcium and PTH returned to normal levels and symptomatic relief occurred after operation.
  
  
  CONCLUSIONS
  Recurrent bone disease, long-term urinary calculus and obscure gastrointestinal symptoms were common symptoms of hyperparathyroidism due to parathyroid tumors. The neck ultrasonography and Tc-99m-MIBI were suitable for location of parathyroid tumors. Surgical operation was an effective treatment for parathyroid tumor. Intra-operative PTH assay would be able to ensure the radical excision and the operative safety for functional parathyroid tumors.
authors.forename: Shanting
authors.initials: S
authors.lastname: Liu
authors.forename: Junfu
authors.initials: J
authors.lastname: Wu
authors.forename: Lu
authors.initials: L
authors.lastname: Feng
authors.forename: Defeng
authors.initials: D
authors.lastname: Chen
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Jinxing
authors.initials: J
authors.lastname: Qi
authors.forename: Wenliang
authors.initials: W
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000209:etiology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010281:Parathyroid Hormone / Q000097:blood*; D010282:Parathyroid Neoplasms / Q000150:complications / Q000601:surgery*; D012189:Retrospective Studies
chemical_list: D010281:Parathyroid Hormone