title: The risk factors and quality of life in patients with overlapping functional dyspepsia or peptic ulcer disease with gastroesophageal reflux disease.
abstract: OBJECTIVE
  Gastroesophageal reflux disease (GERD), functional dyspepsia (FD), and peptic ulcer disease (PUD) impact the daily lives of affected individuals. The aim of this study was to compare the risk factors and impacts on life quality of overlapping FD or PUD in patients with GERD.
  
  
  METHODS
  Data from patients diagnosed with GERD were collected between January and November 2009. FD was defined using the Rome III diagnostic criteria. The overlapping GERD-FD or GERD-PUD groups were classified as concomitant GERD and FD or peptic ulcers. The characteristics of these individuals were analyzed.
  
  
  RESULTS
  There were 63, 48, and 60 patients in the GERD only, overlapping GERD-FD, and overlapping GERD-PUD groups, respectively. Significantly younger age, female gender, lower body weight and body mass index, and higher rates of tea consumption were noted in the GERD-FD group. Patients in the GERD-FD group exhibited the lowest quality of life scores, both with respect to physical and mental health, on the Short Form 36 domains.
  
  
  CONCLUSIONS
  Patients with concomitant GERD and FD were more likely to be younger and female. Overlapping GERD and FD had the worst impact on the quality of life of the affected individuals.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. ; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Shou-Wu
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. ; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Teng-Yu
authors.initials: TY
authors.lastname: Lee
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. ; Department of Medicine, Yang Ming University, Taipei, Taiwan.
authors.forename: Han-Chung
authors.initials: HC
authors.lastname: Lien
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. ; Department of Medicine, Yang Ming University, Taipei, Taiwan.
authors.forename: Hong-Zen
authors.initials: HZ
authors.lastname: Yeh
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. ; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Chi-Sen
authors.initials: CS
authors.lastname: Chang
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. ; Department of Medicine, Yang Ming University, Taipei, Taiwan.
authors.forename: Chung-Wang
authors.initials: CW
authors.lastname: Ko
mesh_terms: D000328:Adult; D000367:Age Factors; D004415:Dyspepsia / Q000150:complications*; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications*; D011788:Quality of Life; D012307:Risk Factors; D011795:Surveys and Questionnaires
keywords: Functional dyspepsia; Gastroesophageal reflux disease; Organic dyspepsia; Peptic ulcer disease; Quality of life