title: Chemoselective palladium-catalyzed cyanation of alkenyl halides.
abstract: A palladium-catalyzed cyanation of alkenyl halides using acetone cyanohydrin is described. A number of structurally diverse alkenylic nitrile containing compounds was prepared in one step under optimized conditions. The reaction proved to be efficient, chemoselective, easy to perform, and tolerant of a number of functional groups.
authors.affiliation: School of Chemistry, University of Nottingham , University Park, Nottingham, NG7 2RD, U.K.
authors.forename: Kimberley J
authors.initials: KJ
authors.lastname: Powell
authors.forename: Li-Chen
authors.initials: LC
authors.lastname: Han
authors.forename: Pallavi
authors.initials: P
authors.lastname: Sharma
authors.forename: John E
authors.initials: JE
authors.lastname: Moses
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D006842:Hydrocarbons, Brominated; D009570:Nitriles; D010165:Palladium; C010833:acetone cyanohydrin