title: Epigenetics of lung cancer.
abstract: Lung cancer is the leading cause of cancer-related mortality in the United States. Epigenetic alterations, including DNA methylation, histone modifications, and noncoding RNA expression, have been reported widely in the literature to play a major role in the genesis of lung cancer. The goal of this review is to summarize the common epigenetic changes associated with lung cancer to give some clarity to its etiology, and to provide an overview of the potential translational applications of these changes, including applications for early detection, diagnosis, prognostication, and therapeutics.
authors.affiliation: Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.
authors.forename: Scott M
authors.initials: SM
authors.lastname: Langevin
authors.affiliation: Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minn.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Kratzke
authors.affiliation: Department of Epidemiology, Brown University, Providence, RI; Department of Pathology and Laboratory Medicine, Brown University, Providence, RI. Electronic address: karl_kelsey@brown.edu.
authors.forename: Karl T
authors.initials: KT
authors.lastname: Kelsey
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics; D002986:Clinical Trials as Topic; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D011379:Prognosis; D012307:Risk Factors; D057170:Translational Research, Biomedical
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs