title: Current topics in the biotechnological production of essential amino acids, functional amino acids, and dipeptides.
abstract: Amino acids play important roles in both human and animal nutrition and in the maintenance of health. Here, amino acids are classified into three groups: first, essential amino acids, which are essential to nutrition; second, functional amino acids, recently found to be important in the promotion of physiological functions; and third, dipeptides, which are used to resolve problematic features of specific free amino acids, such as their instability or insolubility. This review focusses on recent researches concerning the microbial production of essential amino acids (lysine and methionine), functional amino acids (histidine and ornithine), and a dipeptide (L-alanyl-L-glutamine).
authors.affiliation: Bioprocess Development Center, Kyowa Hakko Bio Co., Ltd., 2 Miyukigaoka, Tsukuba, Ibaraki 305-0841, Japan. Electronic address: satoshi.mitsuhashi@kyowa-kirin.co.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mitsuhashi
mesh_terms: D000601:Amino Acids, Essential / Q000096:biosynthesis* / Q000378:metabolism / Q000600:supply & distribution*; D000818:Animals; D001709:Biotechnology / Q000379:methods*; D048230:Corynebacterium glutamicum / Q000378:metabolism; D004151:Dipeptides / Q000096:biosynthesis* / Q000378:metabolism / Q000600:supply & distribution*; D005285:Fermentation; D055951:Functional Food / Q000600:supply & distribution*; D006801:Humans; D060847:Metabolic Engineering; D010453:Peptide Synthases / Q000378:metabolism
chemical_list: D000601:Amino Acids, Essential; D004151:Dipeptides; D010453:Peptide Synthases