title: Sustained autoimmune mechanisms in dermatomyositis.
abstract: Dermatomyositis is an autoimmune disease predominantly affecting skin and muscle. Its poorly understood pathogenesis is increasingly being linked to the overproduction of type 1 interferon-inducible gene transcripts and proteins. Mechanisms have been identified by which chronic sustained accumulation of these proteins might occur and thereby injure tissue in dermatomyositis.
authors.affiliation: Brigham and Women's Hospital, Department of Neurology, and Children's Hospital Informatics Program, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, USA.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Greenberg
mesh_terms: D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D003882:Dermatomyositis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000378:metabolism*; D011971:Receptors, Immunologic; D015398:Signal Transduction
chemical_list: D011971:Receptors, Immunologic; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases
keywords: dermatomyositis; innate immune system; type 1 interferon