title: Experimental design in analytical chemistry--part I: theory.
abstract: This paper reviews the main concepts of experimental design applicable to the optimization of analytical chemistry techniques. The critical steps and tools for screening, including Plackett-Burman, factorial and fractional factorial designs, and response surface methodology such as central composite, Box-Behnken, and Doehlert designs, are discussed. Some useful routines are also presented for performing the procedures.
authors.forename: Heshmatollah
authors.initials: H
authors.lastname: Ebrahimi-Najafabadi
authors.forename: Riccardo
authors.initials: R
authors.lastname: Leardi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Jalali-Heravi
mesh_terms: D000465:Algorithms; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D008962:Models, Theoretical; D012107:Research Design