title: Molecule 16673-34-0: a new tool in our arsenal against inflammation.
abstract: The NLRP3 inflammasome has been shown to modulate IL-1B and IL-18 production, both key molecular regulators of inflammation. This editorial discusses a new molecule 16673-34-0 that inhibits the NLRP3 inflammasome and decreases caspase 1 production following ischemia reperfusion or acute peritonitis in mice.
authors.affiliation: *MedStar Cardiovascular Research Network, MedStar Heart Institute, Medstar Washington Hospital Center, Washington, DC; and †Departamento Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Valencia, Spain.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Lipinski
authors.forename: Juan C
authors.initials: JC
authors.lastname: Frias
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001549:Benzamides / Q000138:chemical synthesis / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D002460:Cell Line; D058847:Inflammasomes / Q000037:antagonists & inhibitors*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D010538:Peritonitis / Q000139:chemically induced / Q000517:prevention & control; D013449:Sulfonamides / Q000138:chemical synthesis / Q000627:therapeutic use*
chemical_list: C000593118:5-chloro-2-methoxy-N-(2-(4-sulfamoylphenyl)ethyl)benzamide; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001549:Benzamides; D001786:Blood Glucose; D002352:Carrier Proteins; D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C492716:Nlrp3 protein, mouse; D013449:Sulfonamides