title: Metachronous multifocal myxoid liposarcoma involving the gastrointestinal tract. Management and literature review.
abstract: Multifocal soft tissue sarcoma is a rare clinical entity occurring in 1% of patients with extremity soft tissue sarcoma and in 4.5% of patients with liposarcoma. Multifocal disease may arise either synchronously or metachronously and has been associated with poor prognosis. Herein, we have described a rare case of metachronous multifocal myxoid liposarcoma involving the gastrointestinal tract that developed 14 months after the resection of a myxoid buttock liposarcoma. Diagnostic evaluation and management of the patient are discussed along with a review of the relevant literature. We conclude that multifocal myxoid liposarcoma is a rare clinical entity that usually represents metastatic disease with poor prognosis. A thorough imaging and careful physical examination are essential in the preoperative evaluation and postoperative follow-up of patients with myxoid extremity liposarcomas, as these tumors are known to have a tendency to spread toward extrapulmonary sites, frequently without pulmonary metastases.
authors.affiliation: Department of Surgery, Army General Hospital, Athens, Greece, Europe.
authors.forename: Nikolaos S
authors.initials: NS
authors.lastname: Salemis
authors.affiliation: Department of Surgery, Army General Hospital, Athens, Greece, Europe.
authors.forename: Charalambos
authors.initials: C
authors.lastname: Seretis
authors.affiliation: Department of Surgery, Army General Hospital, Athens, Greece, Europe.
authors.forename: Fotios
authors.initials: F
authors.lastname: Seretis
authors.affiliation: Department of Medical Oncology, Army General Hospital, Athens, Greece, Europe.
authors.forename: Charalambos
authors.initials: C
authors.lastname: Christofyllakis
authors.affiliation: Department of Surgery, Army General Hospital, Athens, Greece, Europe.
authors.forename: Georgios
authors.initials: G
authors.lastname: Karalis
keywords: Gastrointestinal; metachronous; multifocal; myxoid liposarcoma