title: Serum uric acid can predict higher C-reactive protein levels in apparently healthy men.
abstract: BACKGROUND
  Epidemiological studies have shown an association between coronary heart disease and emerging cardiovascular risk factors, such as, levels of fibrinogen and high-sensitivity C-reactive protein (hs-CRP).
  
  
  OBJECTIVE
  To verify the ability of biochemical indicators in discriminating changes in the levels of hs-CRP and fibrinogen, in apparently healthy adult men.
  
  
  METHODS
  Were evaluated 130 apparently healthy men (20-59 years), having measurement of weight and height. Biochemical measurements (lipid profile, fasting glucose, uric acid, hs-CRP and fibrinogen) were performed. Body mass index, total cholesterol/HDL-c and LDL-c/HDL-c ratios were calculated. It was considered as the cutoff point for hs-CRP values ≥ 0.12 mg/dL and for fibrinogen the 50th percentile of the evaluated sample.
  
  
  RESULTS
  The uric acid showed the best correlation (r = 0.325) and the higher area under the ROC curve (0.704 ± 0.054), showing greater ability to discriminate higher levels of hs-CRP (p < 0.01). The total cholesterol/HDL-c ratio (r = 0.222) and the LDL-c/HDL-c ratio (r = 0.235) showed the best correlations and the higher areas under the ROC curves (0.624 ± 0.049 and 0.624 ± 0.049) in identify higher levels of fibrinogen (p < 0.05).
  
  
  CONCLUSIONS
  The uric acid and the total cholesterol/HDL-c and the LDL-c/HDL-c ratios showed greater ability to identify changes in the levels of hs-CRP and fibrinogen, respectively. It was suggested the use of biochemical markers in the clinical practice, in order to establish preventive action for cardiovascular disease in apparently healthy adult men.
authors.affiliation: Department of Nutrition and Health. Universidade Federal de Viçosa. Minas Gerais. Brazil.. fcvidigal@gmail.com.
authors.forename: Fernanda
authors.initials: F
authors.lastname: de Carvalho Vidigal
authors.affiliation: Department of Nutrition and Health. Universidade Federal de Viçosa. Minas Gerais. Brazil..
authors.forename: Lina Enriqueta Frandsen Paez
authors.initials: LE
authors.lastname: de Lima Rosado
authors.affiliation: Department of Nutrition and Health. Universidade Federal de Viçosa. Minas Gerais. Brazil..
authors.forename: Gilberto
authors.initials: G
authors.lastname: Paixão Rosado
authors.affiliation: Department of Nutrition and Health. Universidade Federal de Viçosa. Minas Gerais. Brazil..
authors.forename: Rita de Cassia
authors.initials: Rde C
authors.lastname: Lanes Ribeiro
authors.affiliation: Department of Nutrition and Health. Universidade Federal de Viçosa. Minas Gerais. Brazil..
authors.forename: Sylvia do Carmo
authors.initials: Sdo C
authors.lastname: Castro Franceschini
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D018570:Risk Assessment / Q000379:methods; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D014527:Uric Acid; D002097:C-Reactive Protein