title: What are the predictors of major depression in adult patients with epilepsy?
abstract: Epilepsy is not only a chronic neurological disorder but also a condition associated with other comorbidities. The purpose of this study was to determine the prevalence of major depression in a cohort of adult patients with epilepsy (PWEs) living in north China, and investigate the predictors of major depression in PWEs. A total of 215 consecutive cases were enrolled and divided into two groups: PWEs with major depression and PWEs without major depression. Patients were assessed for demographic characteristics, epilepsy details, and social status. A total of 65 of 215 (30.23%) PWEs exhibited comorbid major depression. A binary logistic regression model revealed the strong predictor variables of major depression to be drug responsiveness (odds ratio [OR]=0.23; p=0<0.01; 95% CI [0.13-0.39]), presence of chronic medical illnesses (OR=0.19; p=0.015<0.05; 95% CI [0.05-0.72]), and employment status (OR=0.42; p=0.015<0.05; 95% CI [0.21-0.84]).
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Beijing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Kui
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Beijing, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Yingfu
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Beijing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Chenling
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Beijing, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Wenqing
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xiuhua
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Beijing, China.
authors.forename: Sun
authors.initials: S
authors.lastname: Di
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D015897:Comorbidity / Q000639:trends; D003865:Major Depressive Disorder / Q000150:complications / Q000453:epidemiology*; D004827:Epilepsy / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult
keywords: China; chronic illness; depression; drug responsiveness; epilepsy; predictor; social status