title: Competing endogenous RNA: the key to posttranscriptional regulation.
abstract: Competing endogenous RNA, ceRNA, vie with messenger RNAs (mRNAs) for microRNAs (miRNAs) with shared miRNAs responses elements (MREs) and act as modulator of miRNA by influencing the available level of miRNA. It has recently been discovered that, apart from protein-coding ceRNAs, pseudogenes, long noncoding RNAs (lncRNAs), and circular RNAs act as miRNA "sponges" by sharing common MRE, inhibiting normal miRNA targeting activity on mRNA. These MRE sharing elements form the posttranscriptional ceRNA network to regulate mRNA expression. ceRNAs are widely implicated in many biological processes. Recent studies have identified ceRNAs associated with a number of diseases including cancer. This brief review focuses on the molecular mechanism of ceRNA as part of the complex post-transcriptional regulatory circuit in cell and the impact of ceRNAs in development and disease.
authors.affiliation: Gyanxet, BF 286 Salt Lake, Kolkata, West Bengal 700064, India.
authors.forename: Rituparno
authors.initials: R
authors.lastname: Sen
authors.affiliation: Indian Association for the Cultivation of Science, Kolkata, West Bengal 700032, India.
authors.forename: Suman
authors.initials: S
authors.lastname: Ghosal
authors.affiliation: Indian Association for the Cultivation of Science, Kolkata, West Bengal 700032, India.
authors.forename: Shaoli
authors.initials: S
authors.lastname: Das
authors.affiliation: Indian Association for the Cultivation of Science, Kolkata, West Bengal 700032, India.
authors.forename: Subrata
authors.initials: S
authors.lastname: Balti
authors.affiliation: Gyanxet, BF 286 Salt Lake, Kolkata, West Bengal 700064, India ; Indian Association for the Cultivation of Science, Kolkata, West Bengal 700032, India.
authors.forename: Jayprokas
authors.initials: J
authors.lastname: Chakrabarti
mesh_terms: D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D012313:RNA / Q000235:genetics* / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D000079962:RNA, Circular; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D000079962:RNA, Circular; D012333:RNA, Messenger; D012313:RNA