title: Autoimmune neutropenia.
abstract: Autoimmune neutropenia (AIN) is a rare entity caused by antibodies directed against neutrophil-specific antigens. It includes primary and secondary autoimmune neutropenia. Acute autoimmune neutropenia can be related to drug-induced mechanism or viral infections. Chronic autoimmune neutropenias occur in the context of autoimmune diseases, hematological malignancies, such as large granular lymphocyte leukemia, primary immune deficiency syndromes or solid tumors. The therapeutic management depends on the etiology. Granulocyte growth factor is the main therapeutic option, raising the question of their long-term utilization safety. Corticosteroids or immunosuppressive therapy are indicated in infection-related AIN or in case of symptomatic autoimmune disease or LGL leukemia.
authors.affiliation: CHU de Rennes, service d'hématologie clinique, Rennes 35043, France.
authors.forename: Aline
authors.initials: A
authors.lastname: Autrel-Moignet
authors.affiliation: CHU de Rennes, service d'hématologie clinique, Rennes 35043, France; Université Rennes 1, Rennes 35043, France. Electronic address: thierry.lamy@univ-rennes1.fr.
authors.forename: Thierry
authors.initials: T
authors.lastname: Lamy
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009503:Neutropenia / Q000188:drug therapy* / Q000276:immunology; D009504:Neutrophils / Q000276:immunology
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D016179:Granulocyte Colony-Stimulating Factor