title: [Clinical significance of MMP2 overexpression in endometrial adenocarcinoma].
abstract: OBJECTIVE
  To explore the expression of MMP2 and its correlation with the clinical features and prognosis of endometrial adenocarcinoma.
  
  
  METHODS
  We collected paraffin-embedded samples from 81 patients with endometrial adenocarcinoma aged 32 to 80 years to examine the expression of MMP2 using immunohistochemistry. The correlation of MMP2 expression with the clinical characteristics and prognosis of the patients was analyzed.
  
  
  RESULTS
  MMP2 protein was expressed in the cytoplasm of the tumor cells. MMP2 over-expression was negatively correlated with tumor differentiation (P=0.015) and prognosis (P=0.041) of endometrial adenocarcinoma.
  
  
  CONCLUSIONS
  MMP2 over-expression is a potential malignant biomarker in endometrial adenocarcinoma.
authors.affiliation: Tumor Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China. E-mail: lishujun2010@163.com.
authors.forename: Shujun
authors.initials: S
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Shen
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Yang
authors.forename: Aibing
authors.initials: A
authors.lastname: Wu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Tang
authors.forename: Mingchun
authors.initials: M
authors.lastname: Li
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Ling
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2