title: Mouse organ coefficient and abnormal sperm rate analysis with exposure to tap water and source water in Nanjing reach of Yangtze River.
abstract: Organ coefficients (including kidney, testis, liver and spleen coefficient) and abnormal sperm rate were used in our study to reflect the exposure to the Yangzte River water. The concentrations of total dissolved metals and semi-volatile organic compounds in tap and source water were measured by ICP-OES and GC-MS, respectively. After mice were fed with purified water (CK), Nanjing tap water (NJT) and Nanjing source water (NJS) for 90 day, the individual and organs (including kidney, testis, liver and spleen) of each mouse were weighted. And abnormal sperm types (such as hook less, banana-like form, amorphous, folded and two tails) were determined by microscope. The results showed that significant differences of liver coefficient between experimental group (NJT, NJS) and control group (CK) were observed; furthermore liver coefficient is positive correlation with the concentrations of total dissolved metals. However, no significant differences of abnormal sperm rates between experimental group (NJT, NJS) and control group (CK) were noted. So liver coefficient might be more sensitive than other organ coefficients to reflect the exposure to tap water and source water, while abnormal sperm rate could not be used to reveal the exposure to them.
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Xianlin Campus, Nanjing, 210023, People's Republic of China.
authors.forename: Rongfei
authors.initials: R
authors.lastname: Zhang
authors.forename: Liujun
authors.initials: L
authors.lastname: Zhang
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Jiang
authors.forename: Kai
authors.initials: K
authors.lastname: Zheng
authors.forename: Yibin
authors.initials: Y
authors.lastname: Cui
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Wu
authors.forename: Shupei
authors.initials: S
authors.lastname: Cheng
mesh_terms: D000818:Animals; D002681:China; D008297:Male; D008670:Metals / Q000032:analysis* / Q000633:toxicity; D008813:Mice, Inbred ICR; D045483:Rivers; D013094:Spermatozoa / Q000187:drug effects*; D055549:Volatile Organic Compounds / Q000032:analysis* / Q000633:toxicity; D014876:Water Pollution / Q000009:adverse effects*; D014881:Water Supply
chemical_list: D008670:Metals; D055549:Volatile Organic Compounds