title: A comprehensive model of the phototransduction cascade in mouse rod cells.
abstract: Vertebrate visual phototransduction is perhaps the most well-studied G-protein signaling pathway. A wealth of available biochemical and electrophysiological data has resulted in a rich history of mathematical modeling of the system. However, while the most comprehensive models have relied upon amphibian biochemical and electrophysiological data, modern research typically employs mammalian species, particularly mice, which exhibit significantly faster signaling dynamics. In this work, we present an adaptation of a previously published, comprehensive model of amphibian phototransduction that can produce quantitatively accurate simulations of the murine photoresponse. We demonstrate the ability of the model to predict responses to a wide range of stimuli and under a variety of mutant conditions. Finally, we employ the model to highlight a likely unknown mechanism related to the interaction between rhodopsin and rhodopsin kinase.
authors.affiliation: IBE - Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), CEXS-UPF-PRBB, Barcelona, Catalonia, Spain.
authors.forename: Brandon M
authors.initials: BM
authors.lastname: Invergo
authors.forename: Daniele
authors.initials: D
authors.lastname: Dell'Orco
authors.forename: Ludovica
authors.initials: L
authors.lastname: Montanucci
authors.forename: Karl-Wilhelm
authors.initials: KW
authors.lastname: Koch
authors.forename: Jaume
authors.initials: J
authors.lastname: Bertranpetit
mesh_terms: D000465:Algorithms; D000663:Amphibians / Q000502:physiology*; D000818:Animals; D019295:Computational Biology / Q000379:methods*; D051606:G-Protein-Coupled Receptor Kinase 1 / Q000378:metabolism; D051379:Mice; D023421:Models, Animal; D008954:Models, Biological; D017948:Retinal Rod Photoreceptor Cells / Q000502:physiology*; D015398:Signal Transduction; D014785:Vision, Ocular
chemical_list: D051606:G-Protein-Coupled Receptor Kinase 1