title: Benefit of azilsartan on blood pressure elevation around rest-to-active phase in spontaneously hypertensive rats.
abstract: Abnormal elevation of blood pressure in early morning (rest-to-active phase) is suggested to cause cardiovascular events. We investigated whether azilsartan (AZL), a novel potent angiotensin receptor blocker, suppresses blood pressure elevation from the light-rest to dark-active phase in spontaneously hypertensive rats (SHRs). AZL has a sustained depressor effect around the rest-to-active phase in SHRs to a greater extent than candesartan (CAN), despite their similar depressor effects for over 24 h. AZL did not cause sympathoexcitation. These results suggest that AZL has a more sustained depressor effect than CAN around the rest-to-active phase in SHRs, and might have advantages for early morning hypertension.
authors.affiliation: Department of Cardiovascular Medicine .
authors.forename: Kengo
authors.initials: K
authors.lastname: Isegawa
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Hirooka
authors.forename: Takuya
authors.initials: T
authors.lastname: Kishi
authors.forename: Keiji
authors.initials: K
authors.lastname: Yasukawa
authors.forename: Hideo
authors.initials: H
authors.lastname: Utsumi
authors.forename: Kenji
authors.initials: K
authors.lastname: Sunagawa
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D001713:Biphenyl Compounds; D001794:Blood Pressure / Q000187:drug effects*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D010069:Oxadiazoles / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D012146:Rest / Q000502:physiology*; D013777:Tetrazoles / Q000494:pharmacology
chemical_list: D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D010069:Oxadiazoles; D013777:Tetrazoles; C521273:azilsartan; C081643:candesartan
keywords: Angiotensin receptor blocker; blood pressure; hypertension; morning surge; sympathetic nervous system