title: Effect of aneurysm and ICA morphology on hemodynamics before and after flow diverter treatment.
abstract: BACKGROUND
  Flow diverter (FD) treatment aims to slow down blood flow inside the aneurysm and increase the average time that blood resides in the aneurysm.
  
  
  OBJECTIVE
  To investigate the relationship between vessel and aneurysm morphology and their influence on the way in which braided FDs change intra-aneurysmal hemodynamics.
  
  
  METHODS
  Twenty-three patient-specific intracranial aneurysm models at the supraclinoid segment of the internal carotid artery were studied. Vessel and aneurysm morphology was quantified and blood flow was modeled with computational fluid dynamics simulations. The relation between morphologic variables and the hemodynamic variables, WSS (wall shear stress) and totime (ratio between the aneurysm volume and inflow at the aneurysm neck), was assessed statistically.
  
  
  RESULTS
  Intra-aneurysmal flow was less dependent on the vessel than on aneurysm morphology. In summary, after treatment with a FD, a greater aneurysm flow reduction and redirection to the vessel main stream should be expected for (a) aneurysms located further away from the curvature peak, (b) aneurysms on the inner side of the bend, (c) aneurysms with no proximal stenosis, and (d) larger aneurysms.
  
  
  CONCLUSIONS
  Although the change in intra-aneurysmal hemodynamics after FD treatment strongly depends on the morphology of the aneurysm, the hemodynamic effect of a FD is also linked to the parent vessel morphology and the position and orientation of the aneurysm with respect to it.
authors.affiliation: Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain Center for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), Universitat Pompeu Fabra, Barcelona, Spain PLADEMA-CONICET and Universidad Nacional del Centro, Tandil, Buenos Aires, Argentina.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Larrabide
authors.affiliation: Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain Center for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Arjan J
authors.initials: AJ
authors.lastname: Geers
authors.affiliation: Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain Center for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Hernán G
authors.initials: HG
authors.lastname: Morales
authors.affiliation: Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain Center for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Martha L
authors.initials: ML
authors.lastname: Aguilar
authors.affiliation: Hirslanden Clinic, Zürich, Switzerland.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Rüfenacht
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D003198:Computer Simulation; D004621:Embolization, Therapeutic / Q000379:methods* / Q000639:trends; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D008955:Models, Cardiovascular; D016896:Treatment Outcome
keywords: Aneurysm; Angiography; Flow Diverter