title: Epidemiology and outcomes in community-acquired versus hospital-acquired AKI.
abstract: OBJECTIVE
  Compared with AKI in hospitalized patients, little is known about patients sustaining AKI in the community and how this differs from AKI in hospital. This study compared epidemiology, risk factors, and short- and long-term outcomes for patients with community-acquired (CA) and hospital-acquired (HA) AKI.
  
  
  METHODS
  A total of 15,976 patients admitted to two district general hospitals between July 11, 2011, and January 15, 2012 were studied. Through use of an electronic database and the AKI Network classification, 686 patients with CA-AKI and 334 patients with HA-AKI were identified. Patients were followed up for 14 months, and data were collated on short-term and long-term renal and patient outcomes.
  
  
  RESULTS
  The incidence of CA-AKI among all hospital admissions was 4.3% compared with an incidence of 2.1% of HA-AKI, giving an overall AKI incidence of 6.4%. Patients with CA-AKI were younger than patients with HA-AKI. Risks for developing HA and CA-AKI were similar and included preexisting CKD, cardiac failure, ischemic heart disease, hypertension, diabetes, dementia, and cancer. Patients with CA-AKI were more likely to have stage 3 AKI and had shorter lengths of hospital stay than patients with HA-AKI. Those with CA-AKI had better (multivariate-adjusted) survival than patients with HA-AKI (hazard ratio, 1.8 [95% CI, 1.44-2.13; P<0.001] for HA-AKI group). Mortality for the CA-AKI group was 45%; 43.7% of these deaths were acute in-hospital deaths. Mortality for the HA-AKI group was 62.9%, with 68.1% of these deaths being acute in-hospital deaths. Renal referral rates were low across the cohorts (8.3%). Renal outcomes were similar in both CA-AKI and HA-AKI groups, with 39.4% and 33.6% of patients in both groups developing de novo CKD or progression of preexisting CKD within 14 months, respectively.
  
  
  CONCLUSIONS
  Patients with CA-AKI sustain more severe AKI than patients with HA-AKI. Despite having risk factors similar to those of patients with HA-AKI, patients with CA AKI have better short- and long-term outcomes.
authors.affiliation: Institute of Nephrology, University Hospital of Wales, Cardiff, United Kingdom.
authors.forename: Alexa
authors.initials: A
authors.lastname: Wonnacott
authors.affiliation: Institute of Nephrology, University Hospital of Wales, Cardiff, United Kingdom merans@cf.ac.uk.
authors.forename: Soma
authors.initials: S
authors.lastname: Meran
authors.affiliation: Institute of Nephrology, University Hospital of Wales, Cardiff, United Kingdom.
authors.forename: Bethan
authors.initials: B
authors.lastname: Amphlett
authors.affiliation: Institute of Nephrology, University Hospital of Wales, Cardiff, United Kingdom.
authors.forename: Bnar
authors.initials: B
authors.lastname: Talabani
authors.affiliation: Institute of Nephrology, University Hospital of Wales, Cardiff, United Kingdom.
authors.forename: Aled
authors.initials: A
authors.lastname: Phillips
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000401:mortality; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D003704:Dementia / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006333:Heart Failure / Q000453:epidemiology; D017052:Hospital Mortality; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D015994:Incidence; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology; D009369:Neoplasms / Q000453:epidemiology; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology*; D012307:Risk Factors; D012720:Severity of Illness Index; D015996:Survival Rate; D014852:Wales / Q000453:epidemiology
keywords: acute renal failure; chronic kidney disease; clinical nephrology