title: Botulinum toxin A in functional popliteal entrapment syndrome: a new approach to a difficult diagnosis.
abstract: Functional Popliteal Entrapment Syndrome (FPES) is caused by compression of neurovascular structures in the popliteal fossa by hypertrophic muscles, provoking severe leg pain with exercise. Treatment is limited to myotomy of hypertrophic musculature. 8 FPES patients underwent imaging and exercise studies, before receiving botulinum toxin A injections (BTX-A) into the gastrocnemius and plantaris muscles. 81.3 % of patients reported clinical improvement on follow-up, and pathological ankle-brachial indices were normalized. BTX-A injection may present a new, safe, effective and non-invasive approach to FPES.
authors.affiliation: Movement Disorders Clinic, Paracelsusring 6A, 14547, Beelitz-Heilstätten, Germany, gandor@parkinson-beelitz.de.
authors.forename: Florin
authors.initials: F
authors.lastname: Gandor
authors.forename: Stephen
authors.initials: S
authors.lastname: Tisch
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Grabs
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Delaney
authors.forename: Lourens
authors.initials: L
authors.lastname: Bester
authors.forename: Paul
authors.initials: P
authors.lastname: Darveniza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D009408:Nerve Compression Syndromes / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D016896:Treatment Outcome; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A