title: Perspectives on antigen presenting cells in zebrafish.
abstract: Antigen presentation is a critical step in the activation of naïve T lymphocytes. In mammals, dendritic cells (DCs), macrophages, and B lymphocytes can all function as antigen presenting cells (APCs). Although APCs have been identified in zebrafish, it is unclear if they fulfill similar roles in the initiation of adaptive immunity. Here we review the characterization of zebrafish macrophages, DCs, and B cells and evidence of their function as true APCs. Finally, we discuss the conservation of APC activity in vertebrates and the use of zebrafish to provide a new perspective on the evolution of these functions.
authors.affiliation: Division of Biological Sciences, University of California, San Diego, La Jolla, CA, United States.
authors.forename: Kanako L
authors.initials: KL
authors.lastname: Lewis
authors.affiliation: Division of Biological Sciences, University of California, San Diego, La Jolla, CA, United States.
authors.forename: Natasha
authors.initials: N
authors.lastname: Del Cid
authors.affiliation: Division of Biological Sciences, University of California, San Diego, La Jolla, CA, United States. Electronic address: dtraver@ucsd.edu.
authors.forename: David
authors.initials: D
authors.lastname: Traver
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D014714:Vertebrates / Q000276:immunology; D015027:Zebrafish / Q000276:immunology*
chemical_list: D006649:Histocompatibility Antigens
keywords: Antigen-presenting cells; B lymphocytes; Dendritic cells; Macrophages; Zebrafish