title: A metabolomic perspective on coeliac disease.
abstract: Metabolomics is an "omic" science that is now emerging with the purpose of elaborating a comprehensive analysis of the metabolome, which is the complete set of metabolites (i.e., small molecules intermediates) in an organism, tissue, cell, or biofluid. In the past decade, metabolomics has already proved to be useful for the characterization of several pathological conditions and offers promises as a clinical tool. A metabolomics investigation of coeliac disease (CD) revealed that a metabolic fingerprint for CD can be defined, which accounts for three different but complementary components: malabsorption, energy metabolism, and alterations in gut microflora and/or intestinal permeability. In this review, we will discuss the major advancements in metabolomics of CD, in particular with respect to the role of gut microbiome and energy metabolism.
authors.affiliation: Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy ; Tuscany Referral Center for Adult Coeliac Disease, Viale Pieraccini 6, 50139 Florence, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Calabrò
authors.affiliation: Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.
authors.forename: Ewa
authors.identifier: 0000-0003-4412-5537
authors.initials: E
authors.lastname: Gralka
authors.affiliation: Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy ; Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy.
authors.forename: Claudio
authors.identifier: 0000-0003-2271-8921
authors.initials: C
authors.lastname: Luchinat
authors.affiliation: Biosystems Data Analysis Group, University of Amsterdam, 904 Science Park, 1098 XH Amsterdam, The Netherlands ; Laboratory of Systems and Synthetic Biology, Wageningen University and Research Center, Dreijenplein 10, 6703 HB Wageningen, The Netherlands.
authors.forename: Edoardo
authors.identifier: 0000-0001-8284-4829
authors.initials: E
authors.lastname: Saccenti
authors.affiliation: Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy ; FiorGen Foundation, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.
authors.forename: Leonardo
authors.identifier: 0000-0001-6438-059X
authors.initials: L
authors.lastname: Tenori