title: Diagnosis of posterior cortical atrophy delayed by coexisting Fuchs' Endothelial Corneal Dystrophy.
abstract: Posterior cortical atrophy (PCA), also known as the visual variant of Alzheimer's Disease, is a rare neurodegenerative disorder that affects the visuospatial systems in its initial stages. Due to the rarity of this condition and the presence of relatively preserved memory during its early stages compared to other dementias, its accurate diagnosis can be delayed. When accompanied by a comorbid visual disorder, the diagnostic process becomes even more challenging. This study describes the disease course of a patient whose diagnosis of Fuchs' Endothelial Corneal Dystrophy served to delay an additional diagnosis of PCA, illustrating the necessity of careful scrutiny of symptom presentation and especially its course.
authors.affiliation: 1Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA.
authors.forename: Dong Y
authors.initials: DY
authors.lastname: Han
authors.forename: Anne L
authors.initials: AL
authors.lastname: Shandera-Ochsner
authors.forename: Brian D
authors.initials: BD
authors.lastname: Bell
authors.forename: Susanne K
authors.initials: SK
authors.lastname: Seeger
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis; D001284:Atrophy / Q000150:complications / Q000175:diagnosis; D066276:Corticomedial Nuclear Complex / Q000473:pathology*; D057210:Delayed Diagnosis; D003937:Diagnosis, Differential; D005260:Female; D005642:Fuchs' Endothelial Dystrophy / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged
keywords: Fuchs’ endothelial corneal dystrophy; cognition; dementia; posterior cortical atrophy; visual variant of Alzheimer’s disease; visuospatial impairment