title: Helicobacter pylori: an overview on antimicrobials and drug delivery systems for its eradication.
abstract: Since the discovery of Helicobacter pylori (H. pylori) in the early 1980s, its eradication has been one of the most important global challenges in gastroenterology. Various circumstances make the treatment with antimicrobials particularly difficult. One problem has been that antibiotics commonly used were designed for the treatment of infections throughout the body rather than for delivering high concentrations locally within the stomach. Many gastroretentive dosage forms were developed in order to eradicate the infection, yet additional advancements are still needed to eliminate the infection completely and decrease its prevalence worldwide. An overview on different antimicrobials and a literature survey about different drug delivery systems used in eradication of H. pylori infection are presented in this review.
authors.forename: Sally A
authors.initials: SA
authors.lastname: El-Zahaby
authors.forename: Abeer A
authors.initials: AA
authors.lastname: Kassem
authors.affiliation: Department of Pharmaceutics, Pharos University in Alexandria, Canal El- Mahmoudia Street, Smouha. Alexandria, Egypt, P.O. Box 37, Sidi Gaber, Alexandria 21311, Egypt. sally.elzahaby@yahoo.com.
authors.forename: Amal H
authors.initials: AH
authors.lastname: El-Kamel
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D016480:Helicobacter pylori / Q000502:physiology; D006801:Humans; D015995:Prevalence; D013270:Stomach / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents