title: Adaptive control of artificial pancreas systems - a review.
abstract: Artificial pancreas (AP) systems offer an important improvement in regulating blood glucose concentration for patients with type 1 diabetes, compared to current approaches. AP consists of sensors, control algorithms and an insulin pump. Different AP control algorithms such as proportional-integral-derivative, model-predictive control, adaptive control, and fuzzy logic control have been investigated in simulation and clinical studies in the past three decades. The variability over time and complexity of the dynamics of blood glucose concentration, unsteady disturbances such as meals, time-varying delays on measurements and insulin infusion, and noisy data from sensors create a challenging system to AP. Adaptive control is a powerful control technique that can deal with such challenges. In this paper, a review of adaptive control techniques for blood glucose regulation with an AP system is presented. The investigations and advances in technology produced impressive results, but there is still a need for a reliable AP system that is both commercially viable and appealing to patients with type 1 diabetes.
authors.affiliation: Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
authors.forename: Kamuran
authors.initials: K
authors.lastname: Turksoy
authors.affiliation: Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA Department of Chemical and Biological Engineering, Illinois Institute of Technology, Chicago, IL, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Cinar
mesh_terms: D000465:Algorithms; D000818:Animals; D001698:Biomedical Engineering / Q000379:methods*; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy*; D004867:Equipment Design; D017143:Fuzzy Logic; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D007332:Insulin Infusion Systems; D008328:Man-Machine Systems; D019397:Pancreas, Artificial; D015203:Reproducibility of Results
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: Artificial pancreas; adaptive control; closed-loop systems; diabetes