title: FCGR3B copy number loss rather than gain is a risk factor for systemic lupus erythematous and lupus nephritis: a meta-analysis.
abstract: OBJECTIVE
  Some studies have been performed to elucidate the association between Fc gamma receptor 3B (FCGR3B) copy number (CN) and the risk of systemic lupus erythematosus (SLE) and/or lupus nephritis (LN), yet the results remain conflicting. Therefore, we have undertaken a systematic review of all the studies published and carried out a meta-analysis to obtain a better understanding of the role of FCGR3B CN in the susceptibility of SLE and LN.
  
  
  METHODS
  A computerized literature search was conducted in databases of PubMed, ISI Web of Knowledge for all studies investigating the association between FCGR3B CN and SLE and/or LN, published up to May 2013.
  
  
  RESULTS
  A total of six articles meeting all of the criteria were included in this study. There were five comparisons of SLE between 2490 patients and 4286 controls, and four comparisons of LN between 689 patients and 1924 controls. Our results showed that individuals with FCGR3B CN gain did not suffer an increased risk of SLE or LN as compared to the normal genotype in the total analysis (SLE: OR = 1.07, 95% CI = 0.79-1.45, P = 0.65; LN: OR = 0.83, 95% CI = 0.47-1.46, P = 0.52). However, individuals with FCGR3B CN loss exhibited an increased risk of SLE or LN (SLE: OR = 1.77, 95% CI = 1.51-2.06, P < 0.00001; LN: OR = 2.02, 95% CI = 1.59-2.57, P < 0.00001).
  
  
  CONCLUSIONS
  Our meta-analysis indicated that FCGR3B CN loss rather than CN gain was associated with susceptibility to SLE and LN.
authors.affiliation: Department of Dermatology, Huashan Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Rheumatology and Immunology, Changhai Hospital affiliated to Second Military Medical University, Shanghai, China.
authors.forename: Dongbao
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of Digestive Diseases, Huashan Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Rheumatology and Immunology, Changhai Hospital affiliated to Second Military Medical University, Shanghai, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Rheumatology and Immunology, Changhai Hospital affiliated to Second Military Medical University, Shanghai, China.
authors.forename: Yafei
authors.initials: Y
authors.lastname: Pang
authors.affiliation: Department of Digestive Diseases, Huashan Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Digestive Diseases, Huashan Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Jiucun
authors.initials: J
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D056915:DNA Copy Number Variations / Q000235:genetics*; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D008181:Lupus Nephritis / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D011379:Prognosis; D017452:Receptors, IgG / Q000235:genetics*; D018570:Risk Assessment
chemical_list: C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D017452:Receptors, IgG
keywords: Fc gamma receptor 3B; copy number variations; lupus nephritis; systemic lupus erythematosus