title: Two sides of the same coin: stem cells in cancer and regenerative medicine.
abstract: Multipotent stromal cells (MSCs) derived from bone marrow, adipose tissue, cord blood, and other origins have recently received much attention as potential therapeutic agents with beneficial immunomodulatory and regenerative properties. In their native tissue environment, however, such cells also appear to have essential functions in building and supporting tumor microenvironments, providing metastatic niches, and maintaining cancer hallmarks. Here, we consider the varied roles of these tissue-resident stroma-associated cells, synthesize recent and emerging discoveries, and discuss the role, potential, and clinical applications of MSCs in cancer and regenerative medicine.-Ilmer, M., Vykoukal, J., Recio Boiles, A., Coleman, M., Alt, E. Two sides of the same coin: stem cells in cancer and regenerative medicine.
authors.affiliation: Department of Translational Molecular Pathology and.
authors.forename: Matthias
authors.initials: M
authors.lastname: Ilmer
authors.affiliation: Department of Translational Molecular Pathology and.
authors.forename: Jody
authors.initials: J
authors.lastname: Vykoukal
authors.affiliation: Department of Translational Molecular Pathology and.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Recio Boiles
authors.affiliation: InGeneron, Inc., Houston, Texas, USA; and.
authors.forename: Michael
authors.initials: M
authors.lastname: Coleman
authors.affiliation: Center for Stem Cell and Developmental Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA; Applied Stem Cell Laboratory, Heart and Vascular Institute, Department of Medicine, Tulane University Health Science Center, New Orleans, Louisiana, USA ealtmd@aol.com.
authors.forename: Eckhard
authors.initials: E
authors.lastname: Alt
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D044968:Regenerative Medicine / Q000379:methods*; D013234:Stem Cells / Q000473:pathology* / Q000502:physiology*
keywords: Warburg; epithelial-mesenchymal transition; exosomes; mesenchymal stromal cells