title: Using a holistic approach to assess the impact of engineered nanomaterials inducing toxicity in aquatic systems.
abstract: In this report, we critically reviewed selected intrinsic physicochemical properties of engineered nanomaterials (ENMs) and their role in the interaction of the ENMs with the immediate surroundings in representative aquatic environments. The behavior of ENMs with respect to dynamic microenvironments at the nano-bio-eco interface level, and the resulting impact on their toxicity, fate, and exposure potential are elaborated. Based on this literature review, we conclude that a holistic approach is urgently needed to fulfill our knowledge gap regarding the safety of discharged ENMs. This comparative approach affords the capability to recognize and understand the potential hazards of ENMs and their toxicity mechanisms, and ultimately to establish a quantitative and reliable system to predict such outcomes.
authors.affiliation: Department of Biology, Jackson State University, Jackson, MS 39217, USA.
authors.forename: Xiaojia
authors.initials: X
authors.lastname: He
authors.affiliation: Environmental Science Ph.D. Program, Jackson State University, Jackson, MS 39217, USA.
authors.forename: Winfred G
authors.initials: WG
authors.lastname: Aker
authors.affiliation: Interdisciplinary Nanotoxicity Center, Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39217, USA.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Leszczynski
authors.affiliation: Department of Biology, Jackson State University, Jackson, MS 39217, USA; Environmental Science Ph.D. Program, Jackson State University, Jackson, MS 39217, USA. Electronic address: huey-min.hwang@jsums.edu.
authors.forename: Huey-Min
authors.initials: HM
authors.lastname: Hwang
mesh_terms: D000818:Animals; D006801:Humans; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D014116:Toxicology / Q000379:methods*
chemical_list: D017382:Reactive Oxygen Species
keywords: Aquatic ecosystems; Engineered nanomaterials; Environmental health; Holistic approach