title: Relationship between mean platelet volume elevation and left ventricular mass index in hypertensive patients.
abstract: OBJECTIVE
  To compare the mean platelet volume (MPV; a general marker of platelet activation) in groups of patients with and without hypertension and to analyse its relationship with left ventricular mass index (LVMI).
  
  
  METHODS
  This cross-sectional, observational study enrolled newly diagnosed patients with untreated stage I-II hypertension and healthy control subjects without hypertension. MPV was measured using a haematology analyser. Echocardiography was performed on all of the study participants.
  
  
  RESULTS
  A total of 50 newly diagnosed patients with hypertension and 50 healthy control subjects were enrolled in the study. The majority of the demographic characteristics and laboratory findings were not significantly different between the two groups. The mean ± SD MPV was significantly higher in the hypertensive group compared with the control group (10.3 ± 1.4 fl versus 9.2 ± 1.8 fl, respectively). The mean ± SD LVMI was significantly higher in the hypertensive group compared with the control group (115.9 ± 23.0 g/m(2) versus 95.7 ± 23.4 g/m(2), respectively). There was no significant correlation between MPV and LVMI.
  
  
  CONCLUSIONS
  In patients with untreated hypertension, despite elevated MPV levels there was no correlation between LVMI and MPV.
authors.affiliation: Department of Cardiology, School of Medicine, Firat University, Elazig, Turkey ferzeyn@hotmail.com.
authors.forename: Mustafa Ferzeyn
authors.initials: MF
authors.lastname: Yavuzkir
authors.affiliation: Department of Cardiology, Elazig Training and Research Hospital, Elazig, Turkey.
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Kurtoğlu
authors.affiliation: Department of Cardiology, Elazig Training and Research Hospital, Elazig, Turkey.
authors.forename: Mücahid
authors.initials: M
authors.lastname: Yilmaz
authors.affiliation: Department of Cardiology, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Korkmaz
authors.affiliation: Department of Cardiology, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Çakmak
authors.affiliation: Department of Cardiology, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Dogdu
authors.affiliation: Department of Cardiology, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Necati
authors.initials: N
authors.lastname: Dagli
authors.affiliation: Department of Cardiovascular Surgery, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Uysal
authors.affiliation: Department of Cardiovascular Surgery, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Özgüler
authors.affiliation: Department of Nephrology, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Gürel
authors.affiliation: Department of Cardiology, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Akbulut
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000473:pathology*; D001794:Blood Pressure; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015539:Platelet Activation; D014463:Ultrasonography
keywords: Hypertension; left ventricular mass index; mean platelet volume