title: Ageing and dementia in a longitudinal study of a cohort with Down syndrome.
abstract: BACKGROUND
  A population sample of people with Down syndrome has been studied from infancy and has now been followed up again at age 47 years.
  
  
  METHODS
  Intelligence and language skills were tested and daily living skills assessed. Memory/cognitive deterioration was examined using two test instruments.
  
  
  RESULTS
  Scores on verbal tests of intelligence changed little. Those on a non-verbal test, on self-help skills and on both memory tests showed some decline, even when the scores of those already suffering from dementia were discounted.
  
  
  CONCLUSIONS
  At age 47, scores on most tests of even the majority of the cohort (i.e. those not definitely diagnosed with dementia) showed some decline. While this includes the scores of people who may subsequently develop dementia, it may also reflect the normal ageing process in this population.
authors.affiliation: Gaston Cottages formerly at St George's Hospital, Cranmer Terrace, London, SW170RE, UK.
authors.forename: Janet
authors.initials: J
authors.lastname: Carr
authors.forename: Suzanne
authors.initials: S
authors.lastname: Collins
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D003704:Dementia / Q000523:psychology*; D004314:Down Syndrome / Q000523:psychology*; D006801:Humans; D007360:Intelligence; D007361:Intelligence Tests; D007807:Language Tests; D008137:Longitudinal Studies; D008875:Middle Aged; D014825:Vocabulary
keywords: Down syndrome; dementia; longitudinal