title: Natural history of food protein-induced enterocolitis syndrome.
abstract: OBJECTIVE
  Because of the paucity of reports and variability in the diagnostic criteria utilized, little is known regarding the natural outcome of patients with food protein-induced enterocolitis syndrome (FPIES). Data extracted from referenced manuscripts, as well as allergists' unpublished observations from across the globe, were used to form a cohesive opinion regarding its natural outcome.
  
  
  RESULTS
  All authors concur that there is a generally high rate of recovery for FPIES. The most common foods causing FPIES are milk and soy. Depending upon which study is analyzed, by the age of 3-5 years, approximately 90% of patients recover from their disease. Recovery from FPIES to solid foods, occurs at a later age, but may reflect a later stage of introduction of the food into the diet. An important clinical outcome, although not common, is a shift from FPIES food hypersensitivity to an IgE-mediated food allergy. This necessitates a change in the oral food challenge protocol, if IgE-mediated sensitization is detected.
  
  
  CONCLUSIONS
  Over the past several years, there has been an increasing awareness of FPIES. This knowledge should lead to a more timely diagnosis and should reassure parents and practitioners alike regarding its favorable course.
authors.affiliation: aAllergy and Immunology Institute, Assaf Harofeh Medical Cente bDepartment of Pediatrics, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yitzhak
authors.initials: Y
authors.lastname: Katz
authors.forename: Michael R
authors.initials: MR
authors.lastname: Goldberg
mesh_terms: D000367:Age Factors; D000818:Animals; D004044:Dietary Proteins / Q000009:adverse effects*; D004760:Enterocolitis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008892:Milk / Q000009:adverse effects*; D013025:Glycine max / Q000009:adverse effects*; D013577:Syndrome
chemical_list: D004044:Dietary Proteins