title: [Bone and Stem Cells. Regulation of chondrocyte differentiation from mesenchymal stem cells].
abstract: Chondrocytes are derived from mesenchymal stem cells and play an essential role in endochondral ossification. Transcription factors, Sox9, Runx2, Runx3 and Osterix are critical for endochondral ossification, and regulate differentiation of mesenchymal stem cells into chondrocytes, and proliferation, maturation and apoptosis of chondrocytes. Recent advances in gene cloning approaches utilizing microarray and high-throughput sequencing technologies have revealed functional regulatory mechanisms of these transcription factors and contributed to understanding of molecular mechanisms of complex and harmonious chondrocyte differentiation.
authors.affiliation: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Japan.
authors.forename: Riko
authors.initials: R
authors.lastname: Nishimura
authors.forename: Eriko
authors.initials: E
authors.lastname: Nakamura
authors.forename: Junpei
authors.initials: J
authors.lastname: Kida
authors.forename: Hiroko
authors.initials: H
authors.lastname: Yagi
authors.forename: Kenji
authors.initials: K
authors.lastname: Hata
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000166:cytology* / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology*; D019902:Chondrocytes / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010012:Osteogenesis; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors