title: Antibiotic polymeric nanoparticles for biofilm-associated infection therapy.
abstract: Polymeric nanoparticles are highly attractive as drug delivery vehicles due to their high structural integrity, stability during storage, ease of preparation and functionalization, and controlled release capability. Similarly, lipid-polymer hybrid nanoparticles, which retain the benefits of polymeric nanoparticles plus the enhanced biocompatibility and prolonged circulation time owed to the lipids, have recently emerged as a superior alternative to polymeric nanoparticles. Drug nanoparticle complex prepared by electrostatic interaction of oppositely charged drug and polyelectrolytes represents another type of polymeric nanoparticle. This chapter details the preparation, characterization, and antibiofilm efficacy testing of antibiotic-loaded polymeric and hybrid nanoparticles and antibiotic nanoparticle complex.
authors.affiliation: Division of Chemical and Biomolecular Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, N1.2-B2-31, 62 Nanyang Drive, Singapore, 639798, Singapore.
authors.forename: Wean Sin
authors.initials: WS
authors.lastname: Cheow
authors.forename: Kunn
authors.initials: K
authors.lastname: Hadinoto
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects*; D016503:Drug Delivery Systems; D008055:Lipids / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D008055:Lipids; D011108:Polymers