title: Structural elucidation and synthesis of vialinin C, a new inhibitor of TNF-α production.
abstract: A new inhibitor of TNF-α production (IC50=0.89 μM) named vialinin C (1) was isolated from dry fruiting bodies of an edible Chinese mushroom, Thelephora vialis. The structure of 1 was determined by high-resolution MS, NMR spectroscopic analysis, and confirmed by synthesis. Synthesis of ganbajunin B (5) obtained from the same origin was also described.
authors.affiliation: RIKEN, Wako-shi, Saitama 351-0198, Japan; Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
authors.forename: Yue Qi
authors.initials: YQ
authors.lastname: Ye
authors.affiliation: Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
authors.forename: Chiemi
authors.initials: C
authors.lastname: Negishi
authors.affiliation: RIKEN, Wako-shi, Saitama 351-0198, Japan.
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Hongo
authors.affiliation: RIKEN, Wako-shi, Saitama 351-0198, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koshino
authors.affiliation: Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Onose
authors.affiliation: Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan. Electronic address: abe@nodai.ac.jp.
authors.forename: Naoki
authors.initials: N
authors.lastname: Abe
authors.affiliation: RIKEN, Wako-shi, Saitama 351-0198, Japan. Electronic address: shunyat@riken.jp.
authors.forename: Shunya
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D000363:Agaricales / Q000737:chemistry / Q000378:metabolism; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010226:Parabens / Q000138:chemical synthesis* / Q000737:chemistry; D013730:Terphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D001572:Benzofurans; D010226:Parabens; D013730:Terphenyl Compounds; D014409:Tumor Necrosis Factor-alpha; C000593359:vialinin C
keywords: TNF-α; Vialinin A; Vialinin B; Vialinin C