title: A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles.
abstract: This report describes a straightforward but robust tubing method for connecting polydimethylsiloxane (PDMS) microfluidic devices to external equipment. The interconnection is irreversible and can sustain a pressure of up to 4.5 MPa that is characterized experimentally and theoretically. To demonstrate applications of this high-pressure tubing technique, we fabricate a semicircular microfluidic channel to implement a high-throughput, size-controlled synthesis of poly(lactic-co-glycolic acid) (PLGA) nanoparticles ranging from 55 to 135 nm in diameter. This microfluidic device allows for a total flow rate of 410 mL h(-1), resulting in enhanced convective mixing which can be utilized to precipitate small size nanoparticles with a good dispersion. We expect that this tubing technique would be widely used in microfluidic chips for nanoparticle synthesis, cell manipulation, and potentially nanofluidic applications.
authors.affiliation: Beijing Engineering Research Center for BioNanotechnology & Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China. xingyujiang@nanoctr.cn sunjs@nanoctr.cn.
authors.forename: Jidong
authors.initials: J
authors.lastname: Wang
authors.forename: Wenwen
authors.initials: W
authors.lastname: Chen
authors.forename: Jiashu
authors.initials: J
authors.lastname: Sun
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Qifang
authors.initials: Q
authors.lastname: Yin
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.forename: Yunlei
authors.initials: Y
authors.lastname: Xianyu
authors.forename: Xinghua
authors.initials: X
authors.lastname: Shi
authors.forename: Guoqing
authors.initials: G
authors.lastname: Hu
authors.forename: Xingyu
authors.initials: X
authors.lastname: Jiang
mesh_terms: D004129:Dimethylpolysiloxanes / Q000737:chemistry; D004867:Equipment Design; D019344:Lactic Acid / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011312:Pressure
chemical_list: D004129:Dimethylpolysiloxanes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C013830:baysilon