title: Development and regulation of RORγt(+) innate lymphoid cells.
abstract: RORγt(+) innate lymphoid cells (ILCs), or ILC3, play a fundamental role in the development of lymphoid tissues, as well as in homeostasis and defence of mucosal tissues. These cells produce IL-22, IL-17A and LTα1β2, key cytokines for the activation of epithelial defences and the recruitment of polymorphonuclear phagocytes. In the absence of ILC3, the early defence to infection and resistance to injury are compromised. Given the importance of ILC3 in mucosal immunity, significant efforts are made to discover their multiple functions and decipher their mode of action and regulation.
authors.affiliation: Institut Pasteur, Development of Lymphoid Tissues Unit, Paris, France.
authors.forename: Sascha
authors.initials: S
authors.lastname: Cording
authors.affiliation: Institut Pasteur, Development of Lymphoid Tissues Unit, Paris, France.
authors.forename: Jasna
authors.initials: J
authors.lastname: Medvedovic
authors.affiliation: INSERM U 1151, Institut Necker Enfants Malades - Faculté de Médecine Paris Descartes, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Cherrier
authors.affiliation: Institut Pasteur, Development of Lymphoid Tissues Unit, Paris, France. Electronic address: gerard.eberl@pasteur.fr.
authors.forename: Gérard
authors.initials: G
authors.lastname: Eberl
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000378:metabolism*
chemical_list: D057132:Nuclear Receptor Subfamily 1, Group F, Member 3
keywords: IL-22; Innate lymphoid cells; Mucosal immunity; RORγt