title: Efficient synthesis of functionalized benzo[b][1,8]naphthyridine derivatives via three-component reaction catalyzed by L-proline.
abstract: A facile and efficient one-pot procedure for the preparation of functionalized benzo[b][1,8]naphthyridine derivatives by three-component reaction of 2-chloroquinoline-3-carbaldehyde, 1,3-dicarbonyl compounds, and enaminones catalyzed by l-proline is described. This new protocol has the advantages of environmental friendliness, good yields, and convenient operation.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Fu
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Hu
authors.forename: Xue-Cheng
authors.initials: XC
authors.lastname: Liu
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Huang
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Shi
mesh_terms: D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011392:Proline / Q000737:chemistry*
chemical_list: D001555:Benzene Derivatives; D009287:Naphthyridines; D011392:Proline
keywords: benzo[b][1,8]naphthyridine; l-proline; three-component reaction