title: Non-response to the intensive phase of anti-tuberculosis treatment in children: evaluation and outcome [Short Communication].
abstract: The present study evaluates the causes for the persistence of symptoms and radiological signs after at least 2 months of intensive anti-tuberculosis treatment in children. In this prospective observational study, 26 paediatric patients with partial or no response to anti-tuberculosis treatment after the 2-month intensive phase were enrolled. After a detailed history and workup, it was found that 9 (34.6%) patients had a wrong initial diagnosis, while 12 (46.2%) had either received inadequate treatment or had complications requiring prolonged treatment; 5 (19.2%) failed to respond. Failure to respond to anti-tuberculosis treatment in paediatric tuberculosis seems to be over-diagnosed.
authors.affiliation: Department of Paediatrics, Maulana Azad Medical College, New Delhi, India.
authors.forename: A
authors.initials: A
authors.lastname: Yadav
authors.affiliation: Department of Paediatrics, Maulana Azad Medical College, New Delhi, India.
authors.forename: G R
authors.initials: GR
authors.lastname: Sethi
authors.affiliation: Department of Paediatrics, Maulana Azad Medical College, New Delhi, India.
authors.forename: M
authors.initials: M
authors.lastname: Mantan
authors.affiliation: Department of Paediatrics, Maulana Azad Medical College, New Delhi, India.
authors.forename: D
authors.initials: D
authors.lastname: Dhingra
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003951:Diagnostic Errors; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D017211:Treatment Failure; D014376:Tuberculosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents