title: Effect of sugars in solutions on subjective appetite and short-term food intake in 9- to 14-year-old normal weight boys.
abstract: OBJECTIVE
  The role of sugars in solutions on subjective appetite and food intake (FI) has received little investigation in children. Therefore, we examined the effect of isocaloric solutions (200 kcal/250 ml) of sugars including sucrose, high-fructose corn syrup-55 (HFCS) or glucose, compared with a non-caloric sucralose control, on subjective appetite and FI in 9- to 14-year-old normal weight (NW) boys.
  
  
  METHODS
  NW boys (n=15) received each of the test solutions, in random order, 60 min before an ad libitum pizza meal. Subjective appetite was measured at baseline (0 min), and 15, 30, 45 and 60 min.
  
  
  RESULTS
  Only glucose (P=0.003), but neither sucrose nor HFCS, reduced FI compared with the sucralose control. This led to a higher cumulative energy intake, compared with sucralose, after sucrose (P=0.009) and HFCS (P=0.01), but not after glucose. In all treatment sessions, subjective average appetite increased from baseline to 60 min, but change from baseline average appetite was the highest after sucrose (P<0.005). Furthermore, sucrose (r=-0.59, P=0.02) and HFCS (r=-0.56, P=0.03), but not glucose, were inversely associated with test meal FI when the treatment dose (200 kcal) was expressed on a body weight (kg) basis.
  
  
  CONCLUSIONS
  Change from baseline subjective average appetite was the highest after sucrose, but only the glucose solution suppressed FI at the test meal 60 min later in NW boys.
authors.affiliation: Department of Applied Human Nutrition, Mount Saint Vincent University, Halifax, Nova Scotia, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Van Engelen
authors.affiliation: School of Nutrition, Ryerson University, Toronto, Ontario, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Khodabandeh
authors.affiliation: School of Nutrition, Ryerson University, Toronto, Ontario, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Akhavan
authors.affiliation: School of Nutrition, Ryerson University, Toronto, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Agarwal
authors.affiliation: School of Nutrition, Ryerson University, Toronto, Ontario, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Gladanac
authors.affiliation: School of Nutrition, Ryerson University, Toronto, Ontario, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Bellissimo
mesh_terms: D000293:Adolescent; D001066:Appetite / Q000187:drug effects*; D002648:Child; D004032:Diet; D019422:Dietary Sucrose / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects*; D005247:Feeding Behavior; D005947:Glucose / Q000494:pharmacology*; D066248:High Fructose Corn Syrup / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009765:Obesity / Q000209:etiology; D012016:Reference Values; D012528:Satiety Response / Q000187:drug effects; D016037:Single-Blind Method; D012996:Solutions; D013395:Sucrose / Q000031:analogs & derivatives / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology
chemical_list: D019422:Dietary Sucrose; D066248:High Fructose Corn Syrup; D012996:Solutions; D013549:Sweetening Agents; D013395:Sucrose; C026285:trichlorosucrose; D005947:Glucose