title: Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates.
abstract: OBJECTIVE
  The preparation of novel PEGylated PAMAM (poly-amidoamine) dendrimers for delivery of anti-HIV drug Efavirenz is reported.
  
  
  METHODS
  About 5.0 G PAMAM dendrimers are prepared by ethylene diamine core via Michael addition by divergent method. PEGylation is done by polyethylene glycol 600 using epichlorhydrin as linker. PEGylated 5.0 G PAMAM dendrimers loaded with Efavirenz (EFV) are evaluated for FTIR, DSC, SEM, drug release, and stability studies.
  
  
  CONCLUSIONS
  From the results it is proved that this method is less time consuming, inexpensive, and reproducible. Drug-release studies indicate, PEGylated 5.0 G PAMAM-EFV dendrimers have shown prolonged drug-release property.
authors.affiliation: Department of Pharmaceutics, Hindu College of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.
authors.forename: Suneela
authors.initials: S
authors.lastname: Pyreddy
authors.affiliation: Department of Pharmaceutics, Hindu College of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.
authors.forename: Pandurangan Dinesh
authors.initials: PD
authors.lastname: Kumar
authors.affiliation: School of Pharmacy, University College Sadaya International University, JalanMenara Gading, Kuala Lumpur, Malaysia.
authors.forename: Palanirajan Vijayaraj
authors.initials: PV
authors.lastname: Kumar
keywords: Dendrimers; Michael addition; PEGylation; efavirenz; epichlorhydrin