title: Dynamic hypoxia in scar tissue during human hypertrophic scar progression.
abstract: BACKGROUND
  The skin color of human hypertrophic scar changes dynamically during scar progression.
  
  
  OBJECTIVE
  To investigate whether hypoxia is dynamic during scar progression.
  
  
  METHODS
  Thirty-five patients with early, proliferative, regressive, and mature scars were involved in this study. Tissue oxygen tension was measured before scar surgery. After surgery, the scar stage was further defined using hematoxylin and eosin staining, and microvessel density and hypoxia inducible factor-1 (HIF-1) expression were detected using immunohistochemistry to determine a correlation with oxygen level.
  
  
  RESULTS
  Mild hypoxia is present in early scars, moderate hypoxia in proliferative scars, and severe hypoxia in regressive scars. Oxygen levels then return to normal in mature scars, which was consistent with the dynamic change in microvessel density. Meanwhile, HIF-1 expression also changed dynamically along with alteration in oxygen levels.
  
  
  CONCLUSIONS
  Hypoxia is dynamic in scar tissue and is possibly correlated with scar formation and regression.
authors.affiliation: Burn Center, Ruijin Hospital, Jiaotong University Medical School, Shanghai, China.
authors.forename: JieXing
authors.initials: J
authors.lastname: Zheng
authors.forename: Fei
authors.initials: F
authors.lastname: Song
authors.forename: Shu-Liang
authors.initials: SL
authors.lastname: Lu
authors.forename: Xi-Qiao
authors.initials: XQ
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D001785:Blood Gas Monitoring, Transcutaneous; D015687:Cell Hypoxia; D017439:Cicatrix, Hypertrophic / Q000097:blood* / Q000473:pathology*; D004396:Coloring Agents; D018450:Disease Progression; D004801:Eosine Yellowish-(YS); D005260:Female; D006416:Hematoxylin; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000032:analysis; D008297:Male; D055806:Microvessels; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D013194:Staining and Labeling; D055815:Young Adult
chemical_list: D018952:Antigens, CD34; D004396:Coloring Agents; D051793:Hypoxia-Inducible Factor 1; D010100:Oxygen; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin