title: NADPH oxidase 1 and its derived reactive oxygen species mediated tissue injury and repair.
abstract: Reactive oxygen species are mostly viewed to cause oxidative damage to various cells and induce organ dysfunction after ischemia-reperfusion injury. However, they are also considered as crucial molecules for cellular signal transduction in biology. NADPH oxidase, whose only function is reactive oxygen species production, has been extensively investigated in many cell types especially phagocytes. The deficiency of NADPH oxidase extends the process of inflammation and delays tissue repair, which causes chronic granulomatous disease in patients. NADPH oxidase 1, one member of the NADPH oxidase family, is not only constitutively expressed in a variety of tissues, but also induced to increase expression in both mRNA and protein levels under many circumstances. NADPH oxidase 1 and its derived reactive oxygen species are suggested to be able to regulate inflammation reaction, cell proliferation and migration, and extracellular matrix synthesis, which contribute to the processes of tissue injury and repair.
authors.affiliation: Department of Burns and Plastic Surgery, No. 3 People's Hospital, Institute of Traumatic Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China.
authors.forename: Xiu-Jun
authors.initials: XJ
authors.lastname: Fu
authors.affiliation: Department of Burns and Plastic Surgery, No. 3 People's Hospital, Institute of Traumatic Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China.
authors.forename: Ying-Bo
authors.initials: YB
authors.lastname: Peng
authors.affiliation: Department of Burns and Plastic Surgery, No. 3 People's Hospital, Institute of Traumatic Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China ; Department of Burns, The Fourth Hospital Affiliated to Jinan University, Guangzhou 51022, China.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Hu
authors.affiliation: Department of Burns and Plastic Surgery, No. 3 People's Hospital, Institute of Traumatic Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China.
authors.forename: You-Zhen
authors.initials: YZ
authors.lastname: Shi
authors.affiliation: Department of Burns and Plastic Surgery, No. 3 People's Hospital, Institute of Traumatic Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China ; Department of Dermatology, Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Yao
authors.affiliation: Department of Burns and Plastic Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004847:Epithelial Cells / Q000201:enzymology / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D000074624:NADPH Oxidase 1; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014945:Wound Healing
chemical_list: D017382:Reactive Oxygen Species; D009247:NADH, NADPH Oxidoreductases; D000074624:NADPH Oxidase 1