title: Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma.
abstract: BACKGROUND
  Spindle cell hemangioma is a benign vascular proliferation that usually occurs on acral sites. A recent report showed focal positive staining of Prox1 in spindle cell hemangioma.
  
  
  METHODS
  We performed an immunohistochemical study of spindle cell hemangioma with antibodies to CD31, D2-40, Prox1, smooth muscle actin (SMA) and Wilms tumor-1 (WT-1).
  
  
  RESULTS
  The endothelial cells in spindle cell hemangioma were positive for CD31 and Prox1, focally positive for D2-40 and negative for WT-1, whereas the myoid spindle cells around the endothelial cells were weakly positive for WT-1.
  
  
  CONCLUSIONS
  Our results suggest that spindle cell hemangioma is a lymphatic malformation.
authors.affiliation: Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Tianwen
authors.initials: T
authors.lastname: Gao
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D058846:Antibodies, Monoclonal, Murine-Derived / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D005260:Female; D006391:Hemangioma / Q000378:metabolism / Q000473:pathology*; D018398:Homeodomain Proteins / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis / Q000096:biosynthesis; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D025521:Tumor Suppressor Proteins / Q000032:analysis / Q000096:biosynthesis*; D025721:WT1 Proteins / Q000032:analysis / Q000096:biosynthesis*; D055815:Young Adult; D000098551:Prospero-Related Homeobox 1 Protein
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D014408:Biomarkers, Tumor; D018398:Homeodomain Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D025521:Tumor Suppressor Proteins; D025721:WT1 Proteins; C583751:WT1 protein, human; C500987:monoclonal antibody D2-40; D000098551:Prospero-Related Homeobox 1 Protein
keywords: D2-40; Prox1; Wilms tumor 1 (WT1); lymphatic; spindle cell hemangioma