title: [Roles of rs 6923761 gene variant in glucagon-like peptide 1 receptor on weight, cardiovascular risk factor and serum adipokine levels in morbid obese patients].
abstract: BACKGROUND
  Studies of the GLP-1 receptor have been directed at identifying polymorphisms in the GLP-1 receptor gene that may be a contributing factor in the pathogenesis of diabetes mellitus and cardiovascular risk factors. Nevertheless, the role of GLP-1 variants on body weight, cardiovascular risk factors and adipokines remains unclear in obese patients.
  
  
  OBJECTIVE
  Our aim was to analyze the effects of rs6923761 GLP-1 receptor polymorphism on body weight, cardiovascular risk factors and serum adipokine levels in morbid obese patients.
  
  
  METHODS
  A sample of 175 morbid obese patients was enrolled in a prospective way. Basal fasting glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides concentration and adipokines were measured. Weights, body mass index, waist circumference, fat mass by bioimpedance and blood pressure measures were measured.
  
  
  RESULTS
  87 patients (49,7%) had genotype GG and 88 (50,3%) had; GA (71 patients, 40,6%) or AA (17 patients, 9,7%) (second group). In the group with GG genotype, levels of glucose (4,4 ± 2,3 mg/dl, p < 0,05), tryglicerides (6,8 ± 4,3 mg/dl , p < 0,05), insulin (4,5 ± 2,3 UI/l , p < 0,05) and HOMA (1,5 ± 0,9 units, p < 0,05) were higher than mutant group. No differences were detected in other parameters.
  
  
  CONCLUSIONS
  Data from our study revealed an association with metabolic parameters and rs6923761. Levels of triglycerides, insulin and HOMA were higher in subjects with A alelle than non A allele subjects.
authors.affiliation: Center of Investigation of Endocrinology and Nutrition. Medicine School. Svo de Endocrinología y Nutrición. Hospital Clinico Universitario. University of Valladolid. Valladolid Spain.. dadluis@yahoo.es.
authors.forename: Daniel Antonio
authors.initials: DA
authors.lastname: de Luis
authors.affiliation: Center of Investigation of Endocrinology and Nutrition. Medicine School. Svo de Endocrinología y Nutrición. Hospital Clinico Universitario. University of Valladolid. Valladolid Spain..
authors.forename: David
authors.initials: D
authors.lastname: Pacheco
authors.affiliation: Center of Investigation of Endocrinology and Nutrition. Medicine School. Svo de Endocrinología y Nutrición. Hospital Clinico Universitario. University of Valladolid. Valladolid Spain..
authors.forename: Rocío
authors.initials: R
authors.lastname: Aller
authors.affiliation: Center of Investigation of Endocrinology and Nutrition. Medicine School. Svo de Endocrinología y Nutrición. Hospital Clinico Universitario. University of Valladolid. Valladolid Spain..
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.affiliation: Center of Investigation of Endocrinology and Nutrition. Medicine School. Svo de Endocrinología y Nutrición. Hospital Clinico Universitario. University of Valladolid. Valladolid Spain..
authors.forename: Rosario
authors.initials: R
authors.lastname: Bachiller
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D001835:Body Weight / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005838:Genotype; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000235:genetics*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D018027:Receptors, Glucagon / Q000235:genetics*; D012307:Risk Factors
chemical_list: D054392:Adipokines; C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D018027:Receptors, Glucagon