title: The innate immune response to HIV-1: to sense or not to sense.
abstract: The immune responses to viruses provide a means to quickly alert the host to the presence of an invader, activating a range of intrinsic and adaptive antiviral mechanisms. Several research groups have made advances in understanding the innate immune response to HIV-1, although their findings differ. Some investigators find that the virus slips under the radar of the pattern recognition receptors that sense viruses by co-opting host factors that restrict accessibility of the viral nucleic acids, while others find that the virus is sensed and activates a type-I interferon response. This article reviews the recent findings and discusses the similarities and differences.
authors.affiliation: Department of Microbiology, NYU School of Medicine , New York, New York.
authors.forename: Nathaniel R
authors.initials: NR
authors.lastname: Landau
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D022423:Myeloid Cells / Q000276:immunology / Q000821:virology