title: Relationship between gestational fasting plasma glucose and neonatal birth weight, prenatal blood pressure and dystocia in pregnant Chinese women.
abstract: BACKGROUND
  Little is known about the optimal cut-off point of fasting plasma glucose for the diagnosis of gestational diabetes mellitus for pregnant Chinese women. This study investigates the relationship between gestational fasting plasma glucose and several variables: neonatal birth weight, prenatal blood pressure and dystocia rate of pregnant women. In this study, we hoped to provide a useful tool to screen gestational diabetes mellitus in pregnant Chinese women.
  
  
  METHODS
  For 1058 pregnant women enrolled in our hospital at pregnancy weeks 22-30, fasting plasma glucose, neonatal birth weight and prenatal blood pressure, as well as dystocia conditions, were examined. We analysed the correlations between the following: gestational fasting plasma glucose and neonatal birth weight; prenatal blood pressure and gestational fasting plasma glucose as well as dystocia rate and gestational fasting plasma glucose group.
  
  
  RESULTS
  A modest correlation was observed between gestational fasting plasma glucose and neonatal birth weight (r = 0.093, p = 0.003). The macrosomia rate was smallest when the gestational fasting plasma glucose was in the range 3.51-5.5 mmol/L. Prenatal blood pressure increased linearly with increasing gestational fasting plasma glucose (p = 0.000). There was a significant difference between the dystocia rates in different fasting plasma glucose groups (chi-squared = 13.015, p = 0.043). The results showed that the dystocia rate significantly increased when gestational fasting plasma glucose was >4.9 mmol/L; p = 0.03, OR = 2.156 (95% CI, 1.077-4.318).
  
  
  CONCLUSIONS
  We suggest that the optimal range of gestational fasting plasma glucose for pregnant Chinese women is in the range 3.5-4.9 mmol/L.
authors.affiliation: Department of Endocrinology, The Second People's Hospital of Fujian province, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Cai
authors.forename: Shujuan
authors.initials: S
authors.lastname: Liu
authors.forename: Mingwei
authors.initials: M
authors.lastname: Huang
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Lai
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhongwen
authors.initials: Z
authors.lastname: Zhao
authors.forename: Fangzhen
authors.initials: F
authors.lastname: Wu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
authors.forename: Haiyan
authors.initials: H
authors.lastname: Miu
authors.forename: Shenghan
authors.initials: S
authors.lastname: Lai
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis*; D002681:China / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D004420:Dystocia / Q000453:epidemiology / Q000209:etiology*; D042241:Early Diagnosis; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000209:etiology*; D005320:Fetal Macrosomia / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D058246:Prehypertension / Q000150:complications / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose
keywords: Chinese; dystocia; gestational fasting plasma glucose; neonatal birth weight; pregnant women; prenatal blood pressure