title: [Detection of serum food specific antibodies of 6 common foods in patients with IgA nephropathy].
abstract: OBJECTIVE
  To explore the relationship between the major allergens of 6 common allergic foods and IgA nephropathy.
  
  
  METHODS
  A sensitive sandwich enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of food-specific IgA1, IgG and IgE in 31 patients with IgA nephropathy and 80 healthy volunteers. All the patients were examined for a history of food allergy using a questionnaire.
  
  
  RESULTS
  Serum levels of IgA1 and IgG against the major allergens of the 6 common allergic foods were significantly higher in patients with IgA nephropathy than in healthy volunteers (P<0.05). There was no detectable food-specific IgE antibodies in the two groups. No patients had a clear history of food allergy. All the patients with increased IgG levels specific to 4 or more foods simultaneously had proteinuria.
  
  
  CONCLUSIONS
  Some foods especially the highly allergic ones may participate in the pathogenesis and progression of IgA nephropathy.
authors.affiliation: Institute of Nephrology and Urology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. E-mail: 723729549@qq.com.
authors.forename: Chaomin
authors.initials: C
authors.lastname: Zhou
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Liu
authors.forename: Weiguo
authors.initials: W
authors.lastname: Sui
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Li
authors.forename: Hequn
authors.initials: H
authors.lastname: Zou
mesh_terms: D000328:Adult; D000918:Antibody Specificity; D016022:Case-Control Studies; D005260:Female; D005512:Food Hypersensitivity / Q000145:classification / Q000276:immunology*; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D055815:Young Adult
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007073:Immunoglobulin E