Ultrasound tracking for intra-fractional motion compensation in radiation therapy.
Modern techniques as ion beam therapy or 4D imaging require precise target position information. However, target motion particularly in the abdomen due to respiration or patient movement is still a challenge and demands methods that detect and compensate this motion. Ultrasound represents a non-invasive, dose-free and model-independent alternative to fluoroscopy, respiration belt or optical tracking of the patient surface. Thus, ultrasound based motion tracking was integrated into irradiation with actively scanned heavy ions. In a first in vitro experiment, the ultrasound tracking system was used to compensate diverse sinusoidal target motions in two dimensions. A time delay of ∼200 ms between target motion and reported position data was compensated by a prediction algorithm (artificial neural network). The irradiated films proved feasibility of the proposed method. Furthermore, a practicable and reliable calibration workflow was developed to enable the transformation of ultrasound tracking data to the coordinates of the treatment delivery or imaging system - even if the ultrasound probe moves due to respiration. A first proof of principle experiment was performed during time-resolved positron emission tomography (4DPET) to test the calibration workflow and to show the accuracy of an ultrasound based motion tracking in vitro. The results showed that optical ultrasound tracking can reach acceptable accuracies and encourage further research.
Mediri GmbH, Heidelberg, Germany. Electronic address: j.schwaab@mediri.com.
J
J
Schwaab
GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany.
M
M
Prall
Mediri GmbH, Heidelberg, Germany.
C
C
Sarti
GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany.
R
R
Kaderka
GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany.
C
C
Bert
Heidelberg Ion-Beam Therapy Center (HIT) and Department of Radiation Oncology, Heidelberg University Hospital, Germany.
C
C
Kurz
Heidelberg Ion-Beam Therapy Center (HIT) and Department of Radiation Oncology, Heidelberg University Hospital, Germany; Ludwig Maximilian University, Munich, Germany.
K
K
Parodi
Mediri GmbH, Heidelberg, Germany; Fraunhofer MEVIS, Bremen, Germany.
M
M
Günther
Mediri GmbH, Heidelberg, Germany; Fraunhofer MEVIS, Bremen, Germany.
J
J
Jenne
D019583:Dose Fractionation, Radiation; D063193:Heavy Ion Radiotherapy; D009068:Movement; D049268:Positron-Emission Tomography; D061089:Radiotherapy, Image-Guided / Q000295:instrumentation / Q000379:methods*; D012119:Respiration; D014465:Ultrasonics
Motion correction; Particle therapy; Ultrasound