How Do Gangliosides Regulate RTKs Signaling?
Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are located on the outer leaflet of the plasma membrane in glycolipid-enriched microdomains, where they interact with molecules of signal transduction pathways including receptors tyrosine kinases (RTKs). The role of gangliosides in the regulation of signal transduction has been reported in many cases and in a large number of cell types. In this review, we summarize the current knowledge on the biosynthesis of gangliosides and the mechanism by which they regulate RTKs signaling.
Structural and Functional Glycobiology Unit, UMR CNRS 8576, University of Sciences and Technologies of Lille, 59655 Villeneuve d'Ascq, France. sylvain.julien@univ-lille1.fr.
Sylvain
S
Julien
Structural and Functional Glycobiology Unit, UMR CNRS 8576, University of Sciences and Technologies of Lille, 59655 Villeneuve d'Ascq, France. marie.bobowski@hotmail.fr.
Marie
M
Bobowski
Structural and Functional Glycobiology Unit, UMR CNRS 8576, University of Sciences and Technologies of Lille, 59655 Villeneuve d'Ascq, France. agata.steenackers@hotmail.fr.
Agata
A
Steenackers
INSERM U908, University of Sciences and Technologies of Lille, 59655 Villeneuve d'Ascq, France. xuefen.lebourhis@univ-lille1.fr.
Xuefen
X
Le Bourhis
Structural and Functional Glycobiology Unit, UMR CNRS 8576, University of Sciences and Technologies of Lille, 59655 Villeneuve d'Ascq, France. philippe.delannoy@univ-lille1.fr.
Philippe
P
Delannoy