[NSAIDs and risk of anastomotic leakage after gastrointestinal surgery].
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most popular analgesics administered after open or laparoscopic gastrointestinal surgery. By blocking the cyclooxygenase, they are likely to inhibit fibroblastic response to tissue injury and therefore to impair the healing process. Recent publications, based on large cohorts of patients, have highlighted the significant association between AINS administration and the occurrence of postoperative anastomotic complications. Even if not yet supported by high level methodological proofs, cautions should be placed on the use of this pharmaceutical class in this setting. Many questions remain unresolved, especially concerning the influence of NSAIDs cox-2 selectivity, or administration duration.
AP-HP, université Paris VI, groupe hospitalier Est-Parisien, hôpital Saint-Antoine, département d'anesthésie-réanimation chirurgicale, 75012 Paris, France.
Valérie
V
Bitot
AP-HP, université Paris VI, groupe hospitalier Est-Parisien, hôpital Saint-Antoine, département d'anesthésie-réanimation chirurgicale, 75012 Paris, France. Electronic address: marc.beaussier@sat.aphp.fr.
Marc
M
Beaussier
D057868:Anastomotic Leak / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D015331:Cohort Studies; D003108:Colonic Diseases / Q000601:surgery; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008134:Long-Term Care; D010149:Postoperative Pain / Q000188:drug therapy; D011183:Postoperative Complications / Q000139:chemically induced*; D012002:Rectal Diseases / Q000601:surgery; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors