Neuroinvasion by Chandipura virus.
Chandipura virus (CHPV) is an arthropod borne rhabdovirus associated with acute encephalitis in children below the age of 15 years in the tropical states of India. Although the entry of the virus into the nervous system is among the crucial events in the pathogenesis of CHPV, the exact mechanism allowing CHPV to invade the central nervous system (CNS) is currently poorly understood. In the present review, based on the knowledge of host interactors previously predicted for CHPV, along with the support from experimental data available for other encephalitic viruses, the authors have speculated the various plausible modes by which CHPV could surpass the blood-brain barrier and invade the CNS to cause encephalitis whilst evading the host immune surveillance. Collectively, this review provides a conservative set of potential interactions that can be employed for future experimental validation with a view to better understand the neuropathogenesis of CHPV.
Centre for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector 62, Noida, Uttar Pradesh 201 307, India.
Sreejith
S
Rajasekharan
Centre for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector 62, Noida, Uttar Pradesh 201 307, India.
Jyoti
J
Rana
Centre for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector 62, Noida, Uttar Pradesh 201 307, India.
Sahil
S
Gulati
Department of Microbiology, Ram Lal Anand College, University of Delhi South Campus (UDSC), Benito Juarez Marg, New Delhi 110021, India.
Vandana
V
Gupta
Centre for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector 62, Noida, Uttar Pradesh 201 307, India. Electronic address: sanjay.gupta@jiit.ac.in.
Sanjay
S
Gupta
D002490:Central Nervous System / Q000821:virology*; D004671:Encephalitis, Arbovirus / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007194:India; D018116:Vesiculovirus / Q000502:physiology*; D053586:Virus Internalization
Blood–brain barrier; CNS invasion; Chandipura virus; Encephalitis; Viral replication