Hepatoprotective effect of Matricaria chamomilla.L in paraquat induced rat liver injury.
Paraquat (PQ), an effective and widely used herbicide, has been proven to be safe when appropriately applied to eliminate weeds. However, PQ poisoning is an extremely frustrating clinical condition with a high mortality and with a lack of effective treatments in humans. PQ is known to induce injury via a redox cyclic reaction. The purpose of this study was to investigate the effect of aqueous extract Matricaria chamomilla.L (M. chamomilla) against PQ-induced liver injury in association with its antioxidant activity.The male rats were treated by gastric gavage daily with PQ (5 mg/kg/day) and M. chamomilla (50 mg/kg/day) were administered alone or in combination for 7 days. After treatments, total antioxidant capacity (TAC), total thiol molecules (TTG) levels and catalase (CAT) activity in liver tissue were measured. At the end of the experiment, plasma and lung tissue of the animals was separated. The activity of enzymatic scavengers such as CAT, TAC and TTG were measured in liver homogenate.In this sample, the TAC and TTG were lower in the PQ group as compared with control group. Co-administration of PQ with M. chamomilla extract increased TAC and TTG in liver tissue as compared with PQ group.In conclusion, M. chamomilla as natural antioxidant may be considered beneficial for the protection oxidative liver injury in PQ poisoning.
Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
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Tavakol
Department of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
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Farzad
Laboratory of Plant Cell Biology, Department of Biology, Bu-Ali Sina University, Hamedan, Iran.
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Fariba
Laboratory of Plant Cell Biology, Department of Biology, Bu-Ali Sina University, Hamedan, Iran.
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Abdolkarim
Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
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Hassan
Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
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Seyed-Mostafa
Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
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Akram
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D019610:Cytoprotection / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D031168:Matricaria / Q000737:chemistry*; D018384:Oxidative Stress / Q000187:drug effects*; D010269:Paraquat / Q000633:toxicity*; D008517:Phytotherapy; D010936:Plant Extracts / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013438:Sulfhydryl Compounds / Q000378:metabolism
D000975:Antioxidants; D010936:Plant Extracts; D013438:Sulfhydryl Compounds; D002374:Catalase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010269:Paraquat