Coxsackievirus A6 and enterovirus 71 causing hand, foot and mouth disease in Cuba, 2011-2013.
Hand, foot and mouth disease (HFMD) is usually caused by coxsackievirus A16 or enterovirus 71 (EV71). Between 2011 and 2013, HFMD cases were reported from different Cuban provinces. A total of 42 clinical specimens were obtained from 23 patients. Detection, identification and phylogenetic analysis of enterovirus-associated HFMD were carried out by virus isolation, specific enterovirus PCR and partial VP1 sequences. HEV was detected in 11 HFMD cases. Emerging genetic variants of coxsackievirus A6 and EV71 were identified as the causative agents of the Cuban HFMD cases.
"Pedro Kourí" Tropical Medicine Institute, Avenida Novia del Mediodía KM 6 1/2, La Lisa, Marianao 13, P.O. Box 601, CP.11400, Havana, Cuba, magile@ipk.sld.cu.
Magilé C
MC
Fonseca
Luis
L
Sarmiento
Sonia
S
Resik
Yenisleidys
Y
Martínez
Lai Heng
LH
Hung
Luis
L
Morier
Alexander
A
Piñón
Odalys
O
Valdéz
Vivian
V
Kourí
Guelsys
G
González
D000328:Adult; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D003462:Cuba / Q000453:epidemiology; D004770:Enterovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D029821:Enterovirus A, Human / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D007223:Infant; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D015678:Viral Structural Proteins / Q000235:genetics
D012367:RNA, Viral; D015678:Viral Structural Proteins