Presence of Betapapillomavirus in Kaposi sarcoma lesions.
Human herpes virus 8 (HHV 8) is recognized as the necessary cause of Kaposi sarcoma (KS) and in the recent past the human papillomavirus (HPV) has been linked to the development of cutaneous basal cell and squamous cell carcinomas. In a cross sectional study investigating Beta-HPV infections in skin lesions, an unexpected occurrence of HPV DNA was found in KS lesions of HIV infected individuals. Of the 18 KS cases included in the study 16 (89%) had HPV DNA detected. The most common Betapapillomavirus types were HPV14 [15 cases (83.3%)], HPV12 [8 cases (44.4%)], and HPV24 [7 cases (39%)]. Multiple Beta-HPV types were detected in 10 (62.5%) of the participants with HPV DNA positive lesions; of these 7 had a CD4+ count below 350 cells/µl and 3 had CD4+ counts above 350 cells/µl. The presence of Beta-HPV DNA in KS lesions is a newly described phenomenon. Further studies to elucidate the role of Beta-HPV in KS need to be conducted as it is possible that HHV 8 may not be the solitary viral carcinogen in KS tumorigenesis.
Department of Immunology, College of Health Sciences, University of Zimbabwe, Avondale, Harare, Zimbabwe; Department of Medical Laboratory Sciences, College of Health Sciences, University of Zimbabwe, Avondale, Harare, Zimbabwe.
Alltalents T
AT
Murahwa
Faith C
FC
Muchemwa
Kerina
K
Duri
Margaret Z
MZ
Borok
Russell B
RB
Kanyera
Monalisa T
MT
Manhanzva
Munyaradzi P
MP
Mapingure
Babill
B
Stray-Pedersen
D000293:Adolescent; D000328:Adult; D052686:Betapapillomavirus / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000821:virology*; D012878:Skin Neoplasms / Q000821:virology*; D055815:Young Adult
D004279:DNA, Viral