[Susceptibility to azithromycin and other antibiotics in recent isolates of Salmonella, Shigella and Yersinia].
BACKGROUND
Azithromycin represents an alternative option to treat bacterial diarrhea when the antibiotic therapy is indicated. Little is known regarding the susceptibility to azithromycin in enteropathogens in Spain.


METHODS
The MICs of azithromycin were determined by E-test against Salmonella non-typhi (SNT), Shigella and Yersinia isolates collected over the last three years (2010-2012). In addition, the susceptibility to other antibiotics usually used to treat gastrointestinal diseases was determined in these isolates by using a microdilution method.


RESULTS
A total of 139 strains of SNT, Shigella and Yersinia were studied. All of them, except one strain, had a MIC≤16mg/L of azithromycin. In the adult population, 14.7% and 40.6% of SNT and Shigella isolates, respectively, were resistant to at least 2 of following antibiotics: amoxicillin, trimethoprim-sulfamethoxazole and ciprofloxacin. In the pediatric population, 10% of SNT clinical isolates and 28.6% (2/7) of Shigella isolates were resistant to amoxicillin and trimethoprim-sulfamethoxazole.


CONCLUSIONS
In our experience, azithromycin would be a useful antibiotic alternative to treat bacterial diarrhea.
Servicio de Microbiología, Hospital Universitario de Getafe, Getafe, Madrid, España.
Angeles
A
Martín-Pozo
Servicio de Microbiología, Hospital Universitario de Getafe, Getafe, Madrid, España.
David M
DM
Arana
Servicio de Microbiología, Hospital Universitario de Getafe, Getafe, Madrid, España.
Miriam
M
Fuentes
Servicio de Microbiología, Hospital Universitario de Getafe, Getafe, Madrid, España; Facultad de Ciencias Biomédicas, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, España. Electronic address: nachoalos@telefonica.net.
Juan-Ignacio
JI
Alós
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology*; D002648:Child; D006801:Humans; D008826:Microbial Sensitivity Tests; D012475:Salmonella / Q000187:drug effects* / Q000302:isolation & purification; D012760:Shigella / Q000187:drug effects* / Q000302:isolation & purification; D015008:Yersinia enterocolitica / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D017963:Azithromycin
Azithromycin; Azitromicina; Bacterial diarrhea; Diarrea bacteriana; Salmonella; Shigella