Decompressive craniectomy for severe traumatic brain injury: the relationship between surgical complications and the prediction of an unfavourable outcome.
OBJECTIVE
To assess the impact that injury severity has on complications in patients who have had a decompressive craniectomy for severe traumatic brain injury (TBI).


METHODS
This prospective observational cohort study included all patients who underwent a decompressive craniectomy following severe TBI at the two major trauma hospitals in Western Australia from 2004 to 2012. All complications were recorded during this period. The clinical and radiological data of the patients on initial presentation were entered into a web-based model prognostic model, the CRASH (Corticosteroid Randomization After Significant Head injury) collaborators prediction model, to obtain the predicted risk of an unfavourable outcome which was used as a measure of injury severity.


RESULTS
Complications after decompressive craniectomy for severe TBI were common. The predicted risk of unfavourable outcome was strongly associated with the development of neurological complications such as herniation of the brain outside the skull bone defects (median predicted risk of unfavourable outcome for herniation 72% vs. 57% without herniation, p=0.001), subdural effusion (median predicted risk of unfavourable outcome 67% with an effusion vs. 57% for those without an effusion, p=0.03), hydrocephalus requiring ventriculo-peritoneal shunt (median predicted risk of unfavourable outcome 86% for those with hydrocephalus vs. 59% for those without hydrocephalus, p=0.001), but not infection (p=0.251) or resorption of bone flap (p=0.697) and seizures (0.987). We did not observe any associations between timing of cranioplasty and risk of infection or resorption of bone flap after cranioplasty.


CONCLUSIONS
Mechanical complications after decompressive craniectomy including herniation of the brain outside the skull bone defects, subdural effusion, and hydrocephalus requiring ventriculo-peritoneal shunt were more common in patients with a more severe form of TBI when quantified by the CRASH predicted risk of unfavourable outcome. The CRASH predicted risk of unfavourable outcome represents a useful baseline characteristic of patients in observational and interventional trials involving patients with severe TBI requiring decompressive craniectomy.
Department of Neurosurgery, Sir Charles Gairdner Hospital and Royal Perth Hospital, Western Australia, Australia. Electronic address: stephen.honeybul@health.wa.gov.au.
Stephen
S
Honeybul
Department of Intensive Care Medicine and School of Population Health, University of Western Australia, Australia.
Kwok M
KM
Ho
D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000401:mortality* / Q000601:surgery; D056424:Decompressive Craniectomy / Q000009:adverse effects* / Q000379:methods / Q000401:mortality*; D005260:Female; D018460:Fractures, Comminuted / Q000150:complications / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D006849:Hydrocephalus / Q000401:mortality*; D015601:Injury Severity Score; D007431:Intraoperative Complications / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012887:Skull Fractures / Q000150:complications / Q000401:mortality*; D013353:Subdural Effusion / Q000209:etiology / Q000401:mortality*; D013997:Time Factors; D016896:Treatment Outcome; D014904:Western Australia / Q000453:epidemiology
Complications; Decompressive craniectomy; Injury severity