Treatment outcome of ductal carcinoma in situ patients treated with postoperative radiation therapy.
OBJECTIVE
To evaluate the outcome of ductal carcinoma in situ (DCIS) patients who underwent surgery followed by radiation therapy (RT).


METHODS
We retrospectively reviewed 106 DCIS patients who underwent surgery followed by postoperative RT between 1994 and 2006. Ninety-four patients underwent breast-conserving surgery, and mastectomy was performed in 12 patients due to extensive DCIS. Postoperative RT was delivered to whole breast with 50.4 Gy/28 fx. Tumor bed boost was offered to 7 patients (6.6%). Patients with hormonal receptor-positive tumors were treated with hormonal therapy.


RESULTS
The median follow-up duration was 83.4 months (range, 33.4 to 191.5 months) and the median age was 47.8 years. Ten patients (9.4%) had resection margin <1 mm and high-grade and estrogen receptor-negative tumors were observed in 39 (36.8%) and 20 (18.9%) patients, respectively. The 7-year ipsilateral breast tumor recurrence (IBTR)-free survival rate was 95.3%. Resection margin (<1 or ≥1 mm) was the significant prognostic factor for IBTR in univariate and multivariate analyses (p < 0.001 and p = 0.016, respectively).


CONCLUSIONS
Postoperative RT for DCIS can achieve favorable treatment outcome. Resection margin was the important prognostic factor for IBTR in the DCIS patients who underwent postoperative RT.
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.
Yu Jin
YJ
Lim
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.
Kyubo
K
Kim
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea. ; Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea.
Eui Kyu
EK
Chie
Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Wonshik
W
Han
Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Dong Young
DY
Noh
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea. ; Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea.
Sung W
SW
Ha
DCIS; IBTR; Postoperative RT