Shigella stands up to the challenge of adhesion.
The invasion process of S. flexneri is well characterized, but mechanisms underlying this bacterium's adhesion to host cells have remained obscure. In this issue of Cell Host & Microbe, Brotcke Zumsteg et al. (2014) report a surprising role for the Shigella virulence factor IcsA (VirG) as an adhesin.
Laboratoire de Bactériologie Moléculaire, Université Libre de Bruxelles (ULB), Faculté de Médecine, 808 Route de Lennik, 1070 Brussels, Belgium.
Latéfa
L
Biskri
Laboratoire de Bactériologie Moléculaire, Université Libre de Bruxelles (ULB), Faculté de Médecine, 808 Route de Lennik, 1070 Brussels, Belgium. Electronic address: aallaoui@ulb.ac.be.
Abdelmounaaïm
A
Allaoui
D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology*; D001426:Bacterial Proteins / Q000378:metabolism*; D058947:Bacterial Secretion Systems; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D012763:Shigella flexneri / Q000472:pathogenicity*; D014157:Transcription Factors / Q000378:metabolism*
D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D004268:DNA-Binding Proteins; D014157:Transcription Factors; C058483:virG protein, Shigella flexneri