Avascular necrosis of the hip and diffuse idiopathic skeletal hyperostosis during long-term isotretinoin treatment of epidermolytic ichthyosis due to a novel deletion mutation in KRT10.
Department of Dermatology, University Hospital Crosshouse, Kilmarnock, U.K. rlamb@nhs.net.
R C
RC
Lamb
J
J
Lang
A
A
Terron-Kwiatowski
D
D
Baty
W H I
WH
McLean
M
M
Zamiri
D000328:Adult; D003879:Dermatologic Agents / Q000009:adverse effects; D005260:Female; D006621:Hip Joint; D006801:Humans; D017488:Hyperkeratosis, Epidermolytic / Q000188:drug therapy / Q000235:genetics*; D004057:Hyperostosis, Diffuse Idiopathic Skeletal / Q000139:chemically induced* / Q000235:genetics; D015474:Isotretinoin / Q000009:adverse effects; D053550:Keratin-10 / Q000235:genetics*; D010020:Osteonecrosis / Q000139:chemically induced* / Q000235:genetics; D017384:Sequence Deletion / Q000235:genetics*
D003879:Dermatologic Agents; C507493:KRT10 protein, human; D053550:Keratin-10; D015474:Isotretinoin