Diphenyl ditelluride induces anxiogenic-like behavior in rats by reducing glutamate uptake.
Anxiety-related disorders are a common public health issue. Several lines of evidence suggest that altered glutamatergic neurotransmission underlies anxiety. The present study evaluated the effect of diphenyl ditelluride [(PhTe)2] exposure on the behavioral performance of rats and examined whether the behavioral effects could be attributed to changes in the modulation of glutamatergic function. Rats were exposed to (PhTe)2 (subcutaneously) during 8 weeks-final dose one third LD50 (124 μg/kg). The testing schedule included elevated plus-maze, open-field, T-maze, rotorod, and Morris water maze tests. Synaptosomal basal [(3)H] glutamate release and uptake were also evaluated. The time spent in the open arm and the ratio of time spent in the open arm/total were decreased in the (PhTe)2 group. Furthermore, the [(3)H] glutamate uptake was decreased in this experimental group. The results suggest that exposure to (PhTe)2 did not change motor abilities whereas it may result in anxiogenic-like behavior, induced by changes in the glutamatergic system at the pre-synaptic level.
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil.
Eluza Curte
EC
Stangherlin
Cristina Wayne
CW
Nogueira
D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001555:Benzene Derivatives / Q000737:chemistry / Q000633:toxicity*; D001692:Biological Transport / Q000187:drug effects; D018698:Glutamic Acid / Q000378:metabolism / Q000493:pharmacokinetics*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D009942:Organometallic Compounds / Q000737:chemistry / Q000633:toxicity*; D017208:Rats, Wistar; D013574:Synaptosomes / Q000378:metabolism; D014316:Tritium
D001555:Benzene Derivatives; D009942:Organometallic Compounds; C434247:diphenylditelluride; D014316:Tritium; D018698:Glutamic Acid