Mixed bioengineering-chemical synthesis approach for the efficient preparation of Δ7-dafachronic acid.
Combining bioengineering with chemical synthesis has enabled an efficient method for producing Δ7-dafachronic acid, a steroidal hormone associated with nematode germline longevity. Saccharomyces cerevisiae was engineered to produce 7,24-cholestadienol, a convenient starting material for a four-step synthesis of Δ7-dafachronic acid.
Department of Chemistry and ‡Department of Biochemistry and Cell Biology, Rice University , Houston, Texas 77005, United States.
Matias I
MI
Kinzurik
Lachezar V
LV
Hristov
Seiichi P T
SP
Matsuda
Zachary T
ZT
Ball
D000818:Animals; D057005:Bioengineering; D002782:Cholestenes / Q000138:chemical synthesis* / Q000737:chemistry; D017238:Genes, Helminth / Q000502:physiology; D005854:Germ Cells / Q000378:metabolism; D008136:Longevity / Q000502:physiology; D015394:Molecular Structure; D009348:Nematoda / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013256:Steroids
D002782:Cholestenes; D013256:Steroids; C533798:delta7-dafachronic acid