Acute lymphocytic cholangitis and liver failure in an Amur tiger (Panthera tigris altaica).
An adult male Amur tiger (Panthera tigris altaica) with confirmed inflammatory bowel disease developed acute severe icterus, bilirubinuria, bilirubinemia, and elevated bile acids after a diet change. Liver biopsies showed moderate lymphoplasmacytic cholangiohepatitis (lymphocytic cholangitis). The tiger developed neurologic signs including ataxia, tremors, and seizures, as well as epistaxis. Therapy consisted of antibiotics, a steroid anti-inflammatory, vitamins, pro-coagulants, and liver-supportive medicines. The tiger improved from acute liver failure within 3 wk, while the epistaxis began at 3.5 wk and did not resolve until 10.5 wk. The long-term maintenance plan consists of oral prednisolone, metronidazole, ursodiol, and an all muscle-meat beef diet.
Erika K
EK
Crook
Nancy A
NA
Carpenter
D000818:Animals; D000836:Animals, Zoo; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D002761:Cholangitis / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D005938:Glucocorticoids / Q000627:therapeutic use; D017093:Liver Failure / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D046010:Tigers; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D000890:Anti-Infective Agents; D002756:Cholagogues and Choleretics; D005938:Glucocorticoids; D008795:Metronidazole; D014580:Ursodeoxycholic Acid; D011239:Prednisolone