[Membrane protective properties of diastereomers of methylpheophorbide a 13(2)-n-n-octyl-N-(2-hydroxy-3-isobornyl-5-methylbenzyl)amide].
Two diastereomers of methylpheophorbide a 13(2)-N-n-octyl-N-(2-hydroxy-3-isobornyl-5-methylbenzyl)amide were obtained from (+)- and (-)-enantiomers of 2-isobornyl-4-methylphenol. Evaluation of membrane protective and antioxidant activity of individual diastereomers on the model of H2O2-induced hemolysis of blood erythrocytes showed that the stereochemistry of isobornyl substituent in the synthesized conjugates has no effect on their biological activity.
E V
EV
Buravlev
D V
DV
Belykh
I Iu
IIu
Chukicheva
I S
IS
Tarabukina
O G
OG
Shevchenko
A V
AV
Kutchin
D000818:Animals; D001892:Camphanes / Q000737:chemistry*; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003408:Cresols / Q000737:chemistry; D004912:Erythrocytes / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000737:chemistry; D008566:Membranes / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D020011:Protective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism
C588095:13(2)-n-n-octyl-N-(2-hydroxy-3-isobornyl-5-methylbenzyl)amide; D001892:Camphanes; D003408:Cresols; D020011:Protective Agents; D002734:Chlorophyll; C032538:4-cresol; C032625:methylpheophorbide; D006861:Hydrogen Peroxide