[Differential diagnosis between keloid and hypertrophic scars: a new approach by full-field optical coherence tomography].
OBJECTIVE
To evaluate the efficacy of full-field optical coherence tomography to differentiate hypertrophic and keloid scars on ex-vivo tissues.


METHODS
All patients who underwent resection of pathological scar from November 2012 to September 2013 were analyzed. The scars were fixed in formalin and analyzed by conventional histology and full-field optical coherence tomography. The criteria for evaluation were: presence of dermal nodules, presence of cells and hyalinization of collagen.


RESULTS
Nineteen pathological scars were analyzed. Histology found 7 keloid scars, 7 mixed and 3 hypertrophic scars. The sensitivity of optical coherence tomography for the detection of dermal nodules was 100%. This technology was not helpful for detection of cells and hyalinized collagen.


CONCLUSIONS
In the present state of technology, optical coherence tomography did not identify the presence of cells, which makes the differential diagnosis difficult in the case of hypertrophic and keloid scars.
Service de chirurgie plastique et reconstructrice, hôpital Conception, 147, boulevard Baille, 13005 Marseille, France. Electronic address: julia.eraud@ap-hm.fr.
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J
Eraud
Service de chirurgie plastique et reconstructrice, hôpital Conception, 147, boulevard Baille, 13005 Marseille, France. Electronic address: david.gonnelli@ap-hm.fr.
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D
Gonnelli
Service d'anatomie et cytologie pathologique, hôpital Nord, chemin des Bourrely, 13015 Marseille, France. Electronic address: Marion.carmassi@ap-hm.fr.
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M
Carmassi
Service d'anatomie et cytologie pathologique, hôpital Nord, chemin des Bourrely, 13015 Marseille, France. Electronic address: Laurie.bruzzese@gmail.com.
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L
Bruzzese
Service d'anatomie et cytologie pathologique, hôpital Nord, chemin des Bourrely, 13015 Marseille, France. Electronic address: lucilemarie.andrac@ap-hm.fr.
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L
Andrac-Meyer
Service de chirurgie plastique et reconstructrice, hôpital Conception, 147, boulevard Baille, 13005 Marseille, France. Electronic address: Dominique.casanova@ap-hm.fr.
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D
Casanova
Service de chirurgie plastique et reconstructrice, hôpital Conception, 147, boulevard Baille, 13005 Marseille, France. Electronic address: guycamille.magalon@ap-hm.fr.
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G
Magalon
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D017439:Cicatrix, Hypertrophic / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007627:Keloid / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D041623:Tomography, Optical Coherence; D055815:Young Adult
Chéloïde; Cicatrices hypertrophiques; Diagnostic différentiel; Differential diagnosis; Full-field optical coherence tomography; Histologie; Histology; Hypertrophic scar; Keloid scar; Tomographie par cohérence optique plein-champ