Role of KSRP in control of type I interferon and cytokine expression.
Cytokines and chemokines are key participants in pathways that drive inflammatory, immune, and other cellular responses to exogenous insults such as infection, trauma, and physiological stress. Persistent and aberrant expression of these factors has been linked to autoimmune, degenerative, and neoplastic diseases. Consequently, cytokine and chemokine expression is tightly governed at each level of gene regulation. Recent studies have demonstrated a role for KH-type splicing regulatory protein (KSRP) in curtailing cytokine and chemokine expression through transcriptional and post-transcriptional mechanisms, including promotion of microRNA maturation. Understanding the role of KSRP in cytokine mRNA metabolism should identify promising targets for the modulation of immune and inflammatory responses.
1 Department of Neurology, University of Alabama at Birmingham , Birmingham, Alabama.
Peter H
PH
King
Ching-Yi
CY
Chen
D000818:Animals; D015551:Autoimmunity; D005786:Gene Expression Regulation; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation / Q000276:immunology; D007370:Interferon Type I / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000276:immunology*; D034622:RNA Interference; D016601:RNA-Binding Proteins / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*
D007370:Interferon Type I; C105789:KHSRP protein, human; D035683:MicroRNAs; D016601:RNA-Binding Proteins; D015534:Trans-Activators