Wrapping of nanoparticles by membranes.
How nanoparticles interact with biomembranes is central for understanding their bioactivity. Biomembranes wrap around nanoparticles if the adhesive interaction between the nanoparticles and membranes is sufficiently strong to compensate for the cost of membrane bending. In this article, we review recent results from theory and simulations that provide new insights on the interplay of bending and adhesion energies during the wrapping of nanoparticles by membranes. These results indicate that the interplay of bending and adhesion during wrapping is strongly affected by the interaction range of the particle-membrane adhesion potential, by the shape of the nanoparticles, and by shape changes of membrane vesicles during wrapping. The interaction range of the particle-membrane adhesion potential is crucial both for the wrapping process of single nanoparticles and the cooperative wrapping of nanoparticles by membrane tubules.
Max Planck Institute of Colloids and Interfaces, Department of Theory and Bio-Systems, Science Park Golm, 14424 Potsdam, Germany.
Amir H
AH
Bahrami
Max Planck Institute of Colloids and Interfaces, Department of Theory and Bio-Systems, Science Park Golm, 14424 Potsdam, Germany.
Michael
M
Raatz
Max Planck Institute of Colloids and Interfaces, Department of Theory and Bio-Systems, Science Park Golm, 14424 Potsdam, Germany.
Jaime
J
Agudo-Canalejo
Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, 10623 Berlin, Germany.
Raphael
R
Michel
Department of Chemical and Biomolecular Engineering, North Carolina State University, Engineering Building I, 911 Partners Way, Raleigh, NC 27695-7905, USA.
Emily M
EM
Curtis
Department of Chemical and Biomolecular Engineering, North Carolina State University, Engineering Building I, 911 Partners Way, Raleigh, NC 27695-7905, USA.
Carol K
CK
Hall
Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, 10623 Berlin, Germany.
Michael
M
Gradzielski
Max Planck Institute of Colloids and Interfaces, Department of Theory and Bio-Systems, Science Park Golm, 14424 Potsdam, Germany.
Reinhard
R
Lipowsky
Max Planck Institute of Colloids and Interfaces, Department of Theory and Bio-Systems, Science Park Golm, 14424 Potsdam, Germany. Electronic address: thomas.weikl@mpikg.mpg.de.
Thomas R
TR
Weikl
D000268:Adhesiveness; D000465:Algorithms; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics / Q000379:methods* / Q000639:trends; D002462:Cell Membrane / Q000737:chemistry*; D004548:Elasticity; D004735:Energy Transfer; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D013499:Surface Properties
D008051:Lipid Bilayers
Bending energy; Membranes; Nanoparticles