Elements in maternal blood and amniotic fluid determined by ICP-MS.
OBJECTIVE
Knowledge about levels of toxic and non-toxic elements in amniotic fluid is limited. The aims of this study were: (1) to measure levels of trace elements Cu, Fe, Zn, B, Sr and Co in amniotic fluid and maternal serum during second trimester of pregnancy; and (2) to determine what correlations exists between elements levels in amniotic fluid and maternal serum.


METHODS
The levels of, iron, copper, zinc, cobalt, strontium and boron were measured in blood and amniotic fluid during genetic amniocentesis using inductively coupled plasma mass spectrometry (ICP-MS).


RESULTS
Concentrations of the elements: Fe, Cu, Zn, Co, Sr and B in amniotic fluid were significantly lower than in maternal blood. For iron, zinc, cobalt, strontium and boron there was a linear correlation between levels in amniotic fluid and maternal serum.


CONCLUSIONS
The concentration of trace elements in amniotic fluid was found to be lower than maternal serum and linearly correlated to its level.
Department of Gynecology and Obstetrics, Soroka University Hospital , Beer-Sheva , Israel .
Tali
T
Silberstein
Magal
M
Saphier
Yardena
Y
Mashiach
Ofra
O
Paz-Tal
Oshra
O
Saphier
D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood*; D011446:Prospective Studies; D012016:Reference Values; D014131:Trace Elements / Q000378:metabolism*
D014131:Trace Elements
Amniotic fluid; inductively coupled plasma mass spectroscopy; trace elements