When PRRs collide: mincle meddles with dectin and toll.
Pattern recognition receptors (PRR) promote pathogen eradication and shape adaptive immunity. Although evidence suggests PRRs can antagonize each other, few detailed mechanisms are known. Wevers et al. (2014) uncover a mechanism of PRR antagonism where fungal-induced Mincle signaling suppresses IL-12 transcription induced by other PRRs and thereby abates antifungal immunity.
Department of Pediatrics, Center for Immunity and Inflammation, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07101, USA. Electronic address: Amariliz.Rivera@rutgers.edu.
Amariliz
A
Rivera
D006801:Humans; D053765:Interleukin-12 Subunit p35 / Q000096:biosynthesis*; D037181:Lectins, C-Type / Q000276:immunology*; D011971:Receptors, Immunologic / Q000276:immunology*; D004718:Saccharomycetales / Q000276:immunology*; D000099181:Dectin-1
D053765:Interleukin-12 Subunit p35; D037181:Lectins, C-Type; D011971:Receptors, Immunologic; D000099181:Dectin-1; C482593:CLEC4D protein, human; C508858:IL12A protein, human