Role of corticosteroids during cardiopulmonary bypass.
Corticosteroids are commonly used in the peri-operative setting for patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). The inflammatory response to CPB is associated with organ dysfunction and increased mortality. Corticosteroids reduce biochemical inflammatory markers associated with CPB, however the impact on clinical outcomes is mixed. The purpose of this article is to evaluate the evidence of changes in clinical outcomes associated with the peri-operative administration of corticosteroids in patients undergoing cardiac surgery with CPB. Randomized, placebo-controlled trials and meta-analyses were reviewed for evidence evaluating the impact of corticosteroids on clinical outcomes including mortality, myocardial infarction, atrial fibrillation (AF), duration of intubation, length of intensive care unit (ICU) or hospital stay, hyperglycemia, and gastrointestinal complications. Most of the relevant studies are underpowered to assess major clinical outcomes. Although corticosteroids likely reduce the risk of AF, this needs to be evaluated when used in addition to or in lieu of other anti-arrhythmic agents. Evidence does not equivocally support the use of corticosteroids to improve clinical outcomes in cardiac surgery patients.
Associate Professor, Department of Pharmacy Practice, Wilkes University , Wilkes-Barre, Pennsylvania.
Judith L
JL
Kristeller
Clinical Pharmacist, Geisinger Medical Center , Danville, Pennsylvania.
Arthur
A
Jankowski
Critical Care Resident, Department of Pharmacy, York Hospital , York, Pennsylvania.
Travis
T
Reinaker
cardiac surgery; cardiopulmonary bypass; corticosteroids