Polymer composites containing gated mesoporous materials for on-command controlled release.
Polyamidic nanofibrous membranes containing gated silica mesoporous particles, acting as carriers, are described as novel hybrid composite materials for encapsulation and on-command delivery of garlic extracts. The carrier system consists of MCM-41 solids functionalized in the outer surface, with linear polyamines (solid P1) and with hydrolyzed starch (solid P2), both acting as molecular gates. Those particles were adsorbed on electospun nylon-6 nanofibrous membranes yielding to composite materials M1 and M2. FE-SEM analysis confirmed the presence of particles incorporated on the nylon nanofibers. The release of the entrapped molecules (garlic extract) from the P1, P2, M1, and M2 materials was evaluated using cyclic voltammetry measurements. Electrochemical studies showed that at acidic pH P1 and M1 were unable to release their entrapped cargo (closed gate), whereas at neutral pH both materials release their loading (open gate). Dealing with P2 and M2 materials, in the absence of pancreatin a negligible release is observed (closed gate), whereas in the presence of enzyme the load is freely to diffuse to the solution. These newly developed composite nanomaterials, provide a homogeneous easy-to-handle system with controlled delivery and bioactive-protective features, having potential applications on pharmacology, medical and engineering fields.
Grupo de Investigación e Innovación alimentaria (CUINA), Universidad Politécnica de Valencia , 46022 Valencia, Spain.
Carolina
C
Acosta
Edgar
E
Pérez-Esteve
Carlos A
CA
Fuenmayor
Simona
S
Benedetti
Maria Stella
MS
Cosio
Juan
J
Soto
Félix
F
Sancenón
Saverio
S
Mannino
José
J
Barat
María D
MD
Marcos
Rámon
R
Martínez-Máñez
D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D033362:Powder Diffraction
D011108:Polymers