Insights into Protein Allostery in the CsoR/RcnR Family of Transcriptional Repressors.
CsoR/RcnR transcriptional repressors adopt a disc-shaped, all α-helical dimer of dimers tetrameric architecture, with a four-helix bundle the key structural feature of the dimer. Individual members of this large family of repressors coordinate Cu(I) or Ni(II)/Co(II) or perform cysteine sulfur chemistry in mitigating the effects of metal or metabolite toxicity, respectively. Here we highlight recent insights into the functional diversity of this fascinating family of repressors.
Department of Chemistry, Indiana University, 212 S. Hawthorne Drive, Bloomington, IN 47405, USA.
Khadine A
KA
Higgins
Department of Chemistry, Indiana University, 212 S. Hawthorne Drive, Bloomington, IN 47405, USA.
David
D
Giedroc