Adhesion molecules as predictors of nasal polyposis recurrence.
BACKGROUND
Nasal polyposis is a chronic inflammation of nasal and paranasal sinuses in the pathogenesis of which adhesion molecules may have a significant role. This study investigates the possible role of certain adhesion molecules, mucins, and oncogenes in nasal polyposis recurrence.


METHODS
A sample study of 21 individuals (17 men and 4 women) aged 47.44 ± 15.10 years with nasal polyposis who had undergone nasal surgery twice was used. Twenty-one individuals aged 46.9 ± 12.8 years suffering from nasal polyposis who had undergone surgery only once in the same period were used as a control sample.


RESULTS
Statistically significant differences between the two groups were observed regarding epithelial membrane antigen (EMA/mucin 1) of stromal cells (p < 0.001) and CD86 stromal expression (p = 0.009). No patient of the control group exhibited high (++) CD86 stromal expression, whereas six patients of the resurgery group did so. When EMA and CD86 were included in a logistic regression model, stromal EMA was found to be positively related to recurrence.


CONCLUSIONS
Adhesion molecules may relate to nasal polyp prognosis and recurrence rates.
Ear, Nose, and Throat Department General Hospital of Larissa, Larissa, Greece.
Dimitrios
D
Batzakakis
Theodoros
T
Stathas
Nikos
N
Mastronikolis
Christos
C
Kourousis
Alexandros
A
Aletras
Stephanos
S
Naxakis
D000328:Adult; D051940:B7-2 Antigen / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D009298:Nasal Polyps / Q000175:diagnosis*; D010256:Paranasal Sinuses / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012008:Recurrence; D017154:Stromal Cells / Q000378:metabolism*
D051940:B7-2 Antigen; D015815:Cell Adhesion Molecules; D018396:Mucin-1