A comprehensive review on controls in molecular imaging: lessons from MMP-2 imaging.
Metalloproteinases (MMPs), including MMP-2, play critical roles in tissue remodeling and are involved in a large array of pathologies, including cancer, arthritis and atherosclerosis. Their prognostic value warranted a large investment or resources in the development of noninvasive detection methods, based on probes for many current clinical and pre-clinical imaging modalities. However, the potential of imaging techniques is only matched by the complexity of the data they generate. This complexity must be properly assessed and accounted for in the early steps of probe design and testing in order to accurately determine the efficacy and efficiency of an imaging strategy. This review proposes basic rules for the evaluation of novel probes by addressing the specific case of MMP targeted probes.
Centre d'imagerie moléculaire de Sherbrooke, Département de médecine nucléaire et radiobiologie, Université de Sherbrooke, Sherbrooke, QC, Canada.
Réjean
R
Lebel
Martin
M
Lepage
D000818:Animals; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D057054:Molecular Imaging / Q000379:methods*; D015335:Molecular Probes; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism
D015335:Molecular Probes; D020778:Matrix Metalloproteinase 2
MMP; MMP-2; MRI; PET; SPECT; controls in molecular imaging; matrix metalloproteinase; optical imaging