Acute colchicine overdose: report of three cases.
Intentional acute toxicity by colchicine is not common but accompanies a high rate of complications and mortality. It is generally assumed to be an emergency in clinical toxicology. Rapid diagnosis and treatment can prevent death. The most common causes of death in this toxicity are acute cardiac failure, shock, and dysrhythmias with hematopoietic complications occurring in later stages. We report three cases of acute colchicine toxicity, two of which expired, with different presenting and ongoing signs and symptoms. We aimed to define the different possible clinical manifestations of the toxicity and review the probable treatments available for these patients.
Department of Forensic Medicine, Iran University of Medical Sciences, Tehran; Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran. hassanian@sbmu.ac.ir.
A
A
Aghabiklooei
N
N
Zamani
H
H
Hassanian-Moghaddam
S
S
Nasouhi
M
M
Mashayekhian
D000328:Adult; D000931:Antidotes / Q000008:administration & dosage; D002606:Charcoal / Q000008:administration & dosage; D002648:Child; D003078:Colchicine / Q000506:poisoning*; D062787:Drug Overdose / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D005751:Gastric Lavage; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D009102:Multiple Organ Failure / Q000139:chemically induced; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000139:chemically induced; D013406:Suicide, Attempted; D016896:Treatment Outcome; D050257:Tubulin Modulators / Q000506:poisoning*
D000931:Antidotes; D050257:Tubulin Modulators; D002606:Charcoal; D003078:Colchicine