Visual problem and low back pain as initial manifestation of multiple myeloma complicating pre-existing systemic sclerosis.
Some connective tissue diseases are associated with an increased risk of developing neoplastic disorders. Association of rheumatoid arthritis and systemic lupus erythematosus with lymphoma, and of dermatomyositis with different malignancies including ovarian and lung cancer has been reported in the literature. Here, we describe a 58 years old man with systemic sclerosis (SSc) for 15 years who developed severe lumbar pain when he was admitted for intravenous infusion of prostaglandin E1 for his fingertip ulcers. He was found to have abnormal skeletal imaging. Laboratory tests including bone marrow aspiration and biopsy determined multiple myeloma causing extensive bony infiltration. The patient expired after two cycles of VAD and Bortezomide chemotherapy.
Department of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Bagher
MB
Owlia
Department of Medicine, University Hospital Zurich, Zurich, Switzerland.
Oliver
O
Distler
Department of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad
M
Foratyazdi
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Mojtaba
M
Akhtari
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001706:Biopsy; D004172:Diplopia / Q000209:etiology*; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D017116:Low Back Pain / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D012595:Scleroderma, Systemic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
D005047:Etoposide; D004317:Doxorubicin