Two-way communications between ubiquitin-like modifiers and DNA.
Many aspects of nucleic acid metabolism, such as DNA replication, repair and transcription, are regulated by the post-translational modifiers ubiquitin and SUMO. Not surprisingly, DNA itself plays an integral part in determining the modification of most chromatin-associated targets. Conversely, ubiquitination or SUMOylation of a protein can impinge on its DNA-binding properties. This review describes mechanistic principles governing the mutual interactions between DNA and ubiquitin or SUMO.
1] Institute of Molecular Biology, Mainz, Germany. [2].
Helle D
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Ulrich
D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D058207:Sumoylation; D025801:Ubiquitin / Q000737:chemistry*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism / Q000502:physiology; D054875:Ubiquitination
D004268:DNA-Binding Proteins; D025801:Ubiquitin; D004247:DNA; D044767:Ubiquitin-Protein Ligases