Study of endothelial dysfunction in patients of psoriatic arthritis by flow mediated and nitroglycerine mediated dilatation of brachial artery.
OBJECTIVE
To study endothelial dysfunction in patients with psoriatic arthritis (PsA) without risk factors for cardiovascular disease.


METHODS
Forty patients with PsA according to Classification Criteria for Psoriatic Arthritis (CASPAR) criteria and forty age- and sex-matched controls were included. Patients with risk factors for cardiovascular disease were excluded. Endothelial function was assessed by measuring endothelial-dependent flow-mediated vasodilatation (FMD%) and endothelial-independent nitroglycerin-mediated dilatation (NMD%) in the brachial artery.


RESULTS
There was a significant impairment of FMD% in patients as compared to controls (mean 8.3% vs. 10.8%, P = 0.007), but there was no significant difference in NMD%.


CONCLUSIONS
There is presence of endothelial dysfunction in patients with PsA independent of risk factors for cardiovascular disease.
Rheumatology Wing, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Aman
A
Sharma
Rheumatology Wing, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Mallapu Hithesh
MH
Reddy
Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Kusum
K
Sharma
Department of Dermatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Sunil
S
Dogra
Department of Cardiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Rajesh
R
Vijayvergiya
D000328:Adult; D015535:Arthritis, Psoriatic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage*; D011237:Predictive Value of Tests; D012039:Regional Blood Flow; D012307:Risk Factors; D014463:Ultrasonography; D014664:Vasodilation; D014665:Vasodilator Agents / Q000008:administration & dosage*; D055815:Young Adult
D014665:Vasodilator Agents; D005996:Nitroglycerin
cardiovascular morbidity; endothelial dysfunction; endothelial-dependent flow-mediated vasodilatation; endothelial-independent nitroglycerine-mediated vasodilatation; flow-mediated vasodilatation; psoriatic arthritis