New terpenes from the Egyptian soft coral Sarcophyton ehrenbergi.
Chemical investigations of the Egyptian soft coral Sarcophyton ehrenbergi have led to the isolation of compounds 1-3 as well as the previously reported marine cembranoid diterpene sarcophine (4). Structures were elucidated by comprehensive NMR and HRMS experimentation. Isolated compounds were in vitro assayed for cytotoxic activity against human hepatocarcinoma (HepG2) and breast adenocarcinoma (MCF-7) cell lines.
Phytochemistry and Plant Systematic Department, National Research Centre, El-Tahrir St., Dokki, Giza 12311, Egypt. chem_ahmed@hotmail.com.
Ahmed
A
Elkhateeb
Department of Chemistry of Natural & Microbial Products, Center of Excellence Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12311, Egypt. aae2eg@yahoo.com.
Ahmed A
AA
El-Beih
Cancer Biology Lab, Center of Excellence for Advanced Sciences & Biochemistry Department, National Research Center, Dokki, Cairo 12311, Egypt. aeldeen7@yahoo.com.
Amira M
AM
Gamal-Eldeen
National Institute of Oceanography and Fisheries, Red Sea Branch, Hurghada 84511, Egypt. coralreef_niof1@yahoo.com.
Montaser A
MA
Alhammady
Graduate School of Biosphere Science, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima 739-852, Japan. ohta@hiroshima-u.ac.jp.
Shinji
S
Ohta
Department of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX 79409, USA. paul.pare@ttu.edu.
Paul W
PW
Paré
Chemistry of Medicinal Plants Department, Center of Excellence Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12311, Egypt. elamir77@live.com.
Mohamed-Elamir F
ME
Hegazy
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D037421:Anthozoa / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D004534:Egypt; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000970:Antineoplastic Agents; D013729:Terpenes; C014804:sarcophine; D015107:4-Butyrolactone