One-step semisynthesis method of spirocurcasone and pyracurcasone from curcusones A and B.
High contents of curcusones A and B and trace amounts of spirocurcasone exist in the roots of Jatropha curcas. Here, a one-step semisynthesis method of spirocurcasone and pyracurcasone was built, not only resulted an increased yield of spirocurcasone but also produced pyracurcasone, which exhibited greater cytotoxicity compared to curcusones A and B. The plausible mechanism of the formation of pyracurcasone was proposed, and the proposed biogenetic origin for spirocurcasone by Taglialatela-Scafati was confirmed.
State Key Laboratory of Photochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan People's Republic of China.
Xu-Yang
XY
Li
Yuan-Feng
YF
Yang
Xing-Rong
XR
Peng
Ming-Ming
MM
Li
Liang-Qun
LQ
Li
Xu
X
Deng
Hong-Bo
HB
Qin
Jie-Qing
JQ
Liu
Ming-Hua
MH
Qiu
D002945:Cisplatin / Q000494:pharmacology; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D018922:HL-60 Cells; D006801:Humans; D031286:Jatropha / Q000737:chemistry; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D013329:Structure-Activity Relationship
D004224:Diterpenes; C502434:curcusone B; C556077:spirocurcasone; D002945:Cisplatin