Synthesis of new benzofuran-1,3-thiazolidin-4-one derivatives from natural sources and study of their antioxidant activity.
Synthesis of benzofuran-1,3-thiazolidinone derivatives is described herein. These compounds were prepared via a concise and short route by condensation reaction of khellinone with aromatic/aliphatic amines followed by cyclization using thioglycolic acid. The newly synthesized compounds were characterized using the well known spectroscopic tools (IR, 1H NMR, and mass spectroscopy), as well as microanalysis. In frames of biological screening of the compounds, antioxidant activity was assessed in vitro.
N A
NA
Abdel Latif
S H
SH
Abdel Hafez
L M
LM
Break
D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry* / Q000378:metabolism; D007666:Khellin / Q000737:chemistry; D010084:Oxidation-Reduction; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology
D000975:Antioxidants; D001572:Benzofurans; D005609:Free Radicals; D013844:Thiazoles; D007666:Khellin; C509273:khellinone