Synthesis of N-(α-fluorovinyl)azoles by the reaction of difluoroalkenes with azoles.
A mild and versatile method for the construction of C-N bonds by the reaction of (2,2-difluorovinyl)arenes with various N-H-containing heterocycles in the presence of K3PO4 has been developed. The reaction proceeded efficiently at room temperature (25 °C) affording the (E)-N-α-fluorovinyl derivatives of azoles 3 in good to excellent yields with relatively high stereoselectivity.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Shanghai 200237, China.
Yang
Y
Xiong
Xuxue
X
Zhang
Tao
T
Huang
Song
S
Cao
D001393:Azoles / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure
D001393:Azoles; D006571:Heterocyclic Compounds; D006845:Hydrocarbons, Fluorinated