Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization-amination cascade reaction.
The chiral gold(i) complex enables enantioselective cycloisomerization-amination of 2-(alkynyl)phenyl boronic acids and diazenes in high yields. A wide scope of substrates bearing various functional groups was tolerated to generate structurally different hydrazide derivatives as a new type of atropisomer.
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. gonglz@ustc.edu.cn.
Rui
R
Guo
Kang-Nan
KN
Li
Bin
B
Liu
Hua-Jie
HJ
Zhu
Yu-Meng
YM
Fan
Liu-Zhu
LZ
Gong
D000586:Amination; D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D006046:Gold / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D007094:Imides / Q000737:chemistry; D013237:Stereoisomerism
D001897:Boronic Acids; D006571:Heterocyclic Compounds; D007094:Imides; D006046:Gold; C038867:diazene