CTLA-4 CT60 (rs3087243) polymorphism and autoimmune thyroid diseases susceptibility: a comprehensive meta-analysis.
OBJECTIVE
To determine whether the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) CT60 polymorphism (rs3087243) confers susceptibility to autoimmune thyroid disease (AITDs).


METHODS
A meta-analysis was performed using: (1) allelic contrast, (2) recessive model and (3) dominant model. Electronic search of PubMed, Medline and Chinese National Knowledge Infrastructure (CNKI) was conducted to select studies.


RESULTS
Finally, a total of 20 separate studies were available for the current meta-analysis: Graves' disease (GD): 18 studies including 1 Iranian, 6 Caucasian and 11 Asian populations; Hashimoto's thyroiditis (HT): seven studies including one Iranian, three Caucasian and three Asian populations. A significant association was found between the CTLA-4 CT60 polymorphism (rs3087243) and GD, with regard to comparisons between allele and genotype frequencies (all p < 0.001). After stratification by ethnicity, significant relationships were consistently identified both in Caucasian and Asian populations. Furthermore, the association between this allelic variant and HT risk was also found in overall and Asian populations (OR: 1.26, 95% CI: 1.10-1.44; OR: 1.45, 95% CI: 1.19-1.76, respectively).


CONCLUSIONS
Taken together, our study suggested that the CT60 polymorphism (rs3087243) in CTLA-4 gene might confer susceptibility to the AITDs (GD/HT).
Department of Epidemiology and Biostatistics, School of Public Health and.
Jing
J
Ni
Li-Juan
LJ
Qiu
Min
M
Zhang
Peng-Fei
PF
Wen
Xiao-Ran
XR
Ye
Yan
Y
Liang
Hai-Feng
HF
Pan
Dong-Qing
DQ
Ye
D000483:Alleles; D015551:Autoimmunity / Q000235:genetics; D060908:CTLA-4 Antigen / Q000235:genetics* / Q000378:metabolism; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D050031:Hashimoto Disease / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D013961:Thyroid Gland / Q000276:immunology
D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human
Autoimmune thyroid diseases; CTLA-4; meta-analysis; single nucleoside polymorphisms; susceptibility