De novo hairy cell leukemia with a major BCR/ABL1 rearrangement: a case report with a literature review.
Hairy cell leukemia (HCL) is a very rare mature B-cell neoplasm and its simultaneous occurrence with chronic myeloid leukemia has been reported in only three cases. The pathogenesis and relationship of the two diseases are not clear. Here we report a case of HCL expressing a BCR/ABL1 clone, which showed molecular remission of the fusion clones and achieved partial remission over nine months of cladribine therapy. After a thorough analysis of previous studies and the results of this patient, we speculate that a subclone evolved to have an additional genetic BCR/ABL1 rearrangement. We also review all published literature on HCL with BCR/ABL1 rearrangement and discuss the pathophysiology of these unusual cases.
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea.
Young-Woong
YW
Won
Sung Jong
SJ
Kim
Tae Sung
TS
Park
Seung Hwan
SH
Oh
Thomas S K
TS
Wan
Eun Jung
EJ
Baek
D000328:Adult; D015321:Gene Rearrangement; D016313:Genes, abl / Q000235:genetics*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000235:genetics / Q000473:pathology*; D008297:Male; D016315:Proto-Oncogene Proteins c-abl / Q000235:genetics*
D016315:Proto-Oncogene Proteins c-abl
BCR/ABL1; cladribine; hairy cell leukemia; therapy