Synthesis and pharmacological evaluation of carvacrol propionate.
This study aimed at synthesizing the carvacrol propionate (CP) and evaluating its pharmacological profile. CP was obtained from carvacrol and propionyl chloride through an esterification reaction. Male Swiss mice were treated with CP (25, 50, or 100 mg/kg). We evaluated the analgesic effect, mechanical hyperalgesia, and anti-inflammatory effect. Pre-treatment with CP inhibited (p<0.01 and 0.001) the formalin-induced nociception in both phases. CP inhibited (p<0.05, 0.01, and 0.001) the development of mechanical hyperalgesia. CP was able to decrease the leukocyte recruitment (p<0.001) and the amount of TNF-α (p<0.001), IL-1β (p<0.05), and protein leakage (p<0.01) into the pleural cavity. In addition, the paw edema was inhibited by CP (p<0.05, 0.01, and 0.001). The CP attenuates nociception, mechanical hyperalgesia, and inflammation, through an inhibition of cytokines.
Department of Physiology, Federal University of Sergipe, Av. Marechal Rondom, s/n, São Cristovão, Brazil.
Marilia Trindade
MT
de Santana
Viviane Barros
VB
Silva
Renan Guedes
RG
de Brito
Priscila Laíse
PL
dos Santos
Sócrates Cabral
SC
de Holanda Cavalcanti
Emiliano Oliveira
EO
Barreto
Jamylle Nunes
JN
de Souza Ferro
Márcio Roberto Viana
MR
dos Santos
Adriano Antunes
AA
de Sousa Araújo
Lucindo José
LJ
Quintans-Júnior
D000818:Animals; D000081007:Cymenes; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D008297:Male; D051379:Mice; D039821:Monoterpenes / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000188:drug therapy / Q000473:pathology; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation
D000081007:Cymenes; D039821:Monoterpenes; D011422:Propionates; C073316:carvacrol; C029658:propionic acid