Lupus flares in two established end-stage renal disease patients with on-line hemodiafiltration during pregnancy - case series.
Many patients with established end-stage renal disease on maintenance dialysis as a result of lupus nephritis are young females in their reproductive years. We report two such patients dialyzed with on-line hemodiafiltration who developed reactivation of lupus disease activity only when they conceived after initial systemic lupus erythematosus burnout. We believe that the flare was triggered by both efficient dialysis and hormonal changes during pregnancy. The flares were treated with oral corticosteroids with an excellent response. Both patients had live births but delivered preterm.
Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia moalthaf@kfshrc.edu.sa.
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Althaf
Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia Internal Medicine Department, Faculty of Medicine, Alexandria University, Egypt.
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Abdelsalam
Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia.
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Alfurayh
D000328:Adult; D005260:Female; D017583:Hemodiafiltration; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008181:Lupus Nephritis / Q000209:etiology*; D011247:Pregnancy
Systemic lupus erythematosus; lupus flare; on-line hemodiafiltration; pregnancy