Postoperative hypoxia and length of intensive care unit stay after cardiac surgery: the underweight paradox?
OBJECTIVE
Cardiac operations with cardiopulmonary bypass can be associated with postoperative lung dysfunction. The present study investigates the incidence of postoperative hypoxia after cardiac surgery, its relationship with the length of intensive care unit stay, and the role of body mass index in determining postoperative hypoxia and intensive care unit length of stay.


METHODS
Single-center, retrospective study.


METHODS
University Hospital. Patients. Adult patients (N = 5,023) who underwent cardiac surgery with CPB.


METHODS
None.


RESULTS
According to the body mass index, patients were attributed to six classes, and obesity was defined as a body mass index >30. POH was defined as a PaO2/FiO2 ratio <200 at the arrival in the intensive care unit. Postoperative hypoxia was detected in 1,536 patients (30.6%). Obesity was an independent risk factor for postoperative hypoxia (odds ratio 2.4, 95% confidence interval 2.05-2.78, P = 0.001) and postoperative hypoxia was a determinant of intensive care unit length of stay. There is a significant inverse correlation between body mass index and PaO2/FiO2 ratio, with the risk of postoperative hypoxia increasing by 1.7 folds per each incremental body mass index class. The relationship between body mass index and intensive care unit length of stay is U-shaped, with longer intensive care unit stay in underweight patients and moderate-morbid obese patients.


CONCLUSIONS
Obese patients are at higher risk for postoperative hypoxia, but this leads to a prolonged intensive care unit stay only for moderate-morbid obese patients. Obese patients are partially protected against the deleterious effects of hemodilution and transfusions. Underweight patients present the "paradox" of a better lung gas exchange but a longer intensive care unit stay. This is probably due to a higher severity of their cardiac disease.
Department of Cardiothoracic - Vascular Anesthesia and Intensive Care, Fondazione Salvatore Maugeri, IRCCS Istituto Scientifico di Montescano, Montescano, Italy.
Marco
M
Ranucci
Department of Cardiothoracic - Vascular Anesthesia and Intensive Care, Fondazione Salvatore Maugeri, IRCCS Istituto Scientifico di Montescano, Montescano, Italy.
Andrea
A
Ballotta
Department of Cardiology, Fondazione Salvatore Maugeri, IRCCS Istituto Scientifico di Montescano, Montescano, Italy.
Maria Teresa
MT
La Rovere
Department of Cardiothoracic - Vascular Anesthesia and Intensive Care, Fondazione Salvatore Maugeri, IRCCS Istituto Scientifico di Montescano, Montescano, Italy.
Serenella
S
Castelvecchio
D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology*; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D011184:Postoperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D013851:Thinness / Q000150:complications*; D016896:Treatment Outcome