Surface anchored metal-organic frameworks as stimulus responsive antifouling coatings.
Surface-anchored, crystalline and oriented metal organic frameworks (SURMOFs) have huge potential for biological applications due to their well-defined and highly-porous structure. In this work we describe a MOF-based, fully autonomous system, which combines sensing, a specific response, and the release of an antimicrobial agent. The Cu-containing SURMOF, Cu-SURMOF 2, is stable in artificial seawater and shows stimulus-responsive anti-fouling properties against marine bacteria. When Cobetia marina adheres on the SURMOF, the framework's response is lethal to the adhering microorganism. A thorough analysis reveals that this response is induced by agents secreted from the microbes after adhesion to the substrate, and includes a release of Cu ions resulting from a degradation of the SURMOF. The stimulus-responsive antifouling effect of Cu-SURMOF 2 demonstrates the first application of Cu-SURMOF 2 as autonomous system with great potential for further microbiological and cell culture applications.
Analytical Chemistry-Biointerfaces, Ruhr-University Bochum, 44780, Bochum, Germany, arpa@uni-heidelberg.de.
Maria Pilar Arpa
MP
Sancet
Maximilian
M
Hanke
Zhengbang
Z
Wang
Stella
S
Bauer
Carlos
C
Azucena
Hasan K
HK
Arslan
Marita
M
Heinle
Hartmut
H
Gliemann
Christof
C
Wöll
Axel
A
Rosenhahn
D057219:Biofouling / Q000517:prevention & control; D008670:Metals / Q000737:chemistry*; D013499:Surface Properties
D008670:Metals