Pd-catalyzed oxidative annulation of hydrazides with isocyanides: synthesis of 2-amino-1,3,4-oxadiazoles.
An efficient palladium-catalyzed oxidative annulation reaction was developed through sequential isocyanide insertions into N-H and O-H bonds of hydrazides, which provides an efficient access to valuable 2-amino-1,3,4-oxadiazoles and their derivatives.
Department of Chemistry, Innovative Drug Research Center, Shanghai University , Shanghai 200444, China.
Tao
T
Fang
Qitao
Q
Tan
Zhengwei
Z
Ding
Bingxin
B
Liu
Bin
B
Xu
D003486:Cyanides / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
D003486:Cyanides; D006834:Hydrazines; D010069:Oxadiazoles; D010165:Palladium