How Tets and cytoskeleton dynamics MET in reprogramming.
Two studies by Sakurai et al. (2014) and Hu et al. (2014) in this issue of Cell Stem Cell add a new level of understanding to the mesenchymal-to-epithelial transition taking place during reprogramming, showing how this morphological transformation is promoted by Tet enzymes and blocked by kinase-dependent cytoskeletal organization.
INSERM, UMR 1064, 44093 Nantes Cedex 1, France; Faculté de Médecine, Université de Nantes, 44035 Nantes Cedex 1, France; iPSC Core Facility, SFR F. Bonamy, Université de Nantes, France. Electronic address: laurent.david@univ-nantes.fr.
Laurent
L
David
Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada.
Calley L
CL
Hirsch
D000818:Animals; D002454:Cell Differentiation; D065150:Cellular Reprogramming / Q000235:genetics*; D003599:Cytoskeleton / Q000378:metabolism*; D045647:DNA Glycosylases / Q000502:physiology*; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000502:physiology*; D049308:Dioxygenases; D053595:Embryonic Stem Cells / Q000166:cytology*; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000502:physiology*
D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C540839:TET1 protein, mouse; D049308:Dioxygenases; C551914:Tet2 protein, mouse; C551915:Tet3 protein, mouse; D017346:Protein Serine-Threonine Kinases; D045647:DNA Glycosylases