Pentafluorosulfanyldifluoroacetic acid: rebirth of a promising building block.
Three novel, easily scalable routes for the synthesis of pentafluorosulfanyldifluoroacetic acid, SF5CF2C(O)OH, are described. Reactions of its acid chloride with amines and alcohols led to a small library of 15 amides and five esters, respectively. The reaction of the acid chloride with phenylmagnesium bromide gave the corresponding acetophenone. Pentafluorosulfanyldifluoroacetonitrile was obtained from pentafluorosulfanyldifluoroacetamide by dehydration with diphosphorus pentoxide.
Department of Chemistry, Advanced Materials Research Laboratory, Clemson University , 91 Technology Drive, Anderson, South Carolina 29625, United States.
Andrej V
AV
Matsnev
Si-Yan
SY
Qing
Mark A
MA
Stanton
Kyle A
KA
Berger
Günter
G
Haufe
Joseph S
JS
Thrasher