The interplay of reovirus with autophagy.
Autophagy participates in multiple fundamental physiological processes, including survival, differentiation, development, and cellular homeostasis. It eliminates cytoplasmic protein aggregates and damaged organelles by triggering a series of events: sequestering the protein substrates into double-membrane vesicles, fusing the vesicles with lysosomes, and then degrading the autophagic contents. This degradation pathway is also involved in various disorders, for instance, cancers and infectious diseases. This paper provides an overview of modulation of autophagy in the course of reovirus infection and also the interplay of autophagy and reovirus.
Institute of Molecular Biology, National Chung Hsing University, Taichung 402, Taiwan.
Hung-Chuan
HC
Chiu
Department of Biology and Chemistry, Azusa Pacific University, Azusa, CA 91702, USA.
Sarah
S
Richart
Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 402, Taiwan.
Fong-Yuan
FY
Lin
Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 402, Taiwan.
Wei-Li
WL
Hsu
Institute of Molecular Biology, National Chung Hsing University, Taichung 402, Taiwan ; Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan ; Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Hung-Jen
0000-0002-1460-1494
HJ
Liu
D001343:Autophagy / Q000235:genetics*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism / Q000821:virology; D066263:Protein Aggregation, Pathological; D012087:Reoviridae / Q000235:genetics* / Q000472:pathogenicity; D012088:Reoviridae Infections / Q000235:genetics* / Q000378:metabolism