Morphological Features of Organelles during Apoptosis: An Overview.
An apoptotic program leading to controlled cell dismantling implies perturbations of nuclear dynamics, as well as changes affecting the organelle structure and distribution. In human cancer cells driven to apoptosis by different stimuli, we have recently investigated the morphological properties of several organelles, including mitochondria, lysosomes, endoplasmic reticulum and Golgi apparatus. In this review, we will discuss the body of evidence in the literature suggesting that organelles are generally relocated and/or degraded during apoptosis, irrespectively of the apoptogenic stimulus and cell type.
Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, 27100 Pavia, Italy. aredia@igm.cnr.it.
Maria Grazia
MG
Bottone
Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, 27100 Pavia, Italy. aredia@igm.cnr.it.
Giada
G
Santin
Istituto di Genetica Molecolare CNR, 27100 Pavia, Italy. aredia@igm.cnr.it.
Francesca
F
Aredia
Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, 27100 Pavia, Italy. graziella.bernocchi@unipv.it.
Graziella
G
Bernocchi
Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, 27100 Pavia, Italy. pelli@unipv.it.
Carlo
C
Pellicciari
Istituto di Genetica Molecolare CNR, 27100 Pavia, Italy. scovassi@igm.cnr.it.
Anna Ivana
AI
Scovassi