Mink S38G gene polymorphism and atrial fibrillation in the Chinese population: a meta-analysis of 1871 participants.
Mink gene S38G polymorphism in the β -subunit of slow activating component of the delayed rectifier potassium channel current potassium channel has been associated with increased atrial fibrillation (AF) risk. However, the individual studies results were still controversial. To investigate the association of Mink S38G gene polymorphisms with AF, a meta-analysis including 1871 subjects from six individual studies was conducted. Mink S38G gene polymorphism was significantly related to AF under allelic (OR:1.380, 95% CI:1.200-1.600, P < 0.00001), recessive (OR:1.193, 95% CI:1.033-1.377, P = 0.017), dominant (OR:1.057, 95% CI:1.025-1.089, P < 0.00001), additive (OR:1.105, 95% CI:1.036-1.178, P = 0.002), homozygous (OR:1.128, 95% CI:1.068-1.191, P < 0.00001), and heterozygous genetic models (OR:1.078, 95% CI:1.014-1.146, P = 0.016). A significant association between Mink S38G gene polymorphism and AF risk was found. G allele carriers may predispose to AF.
Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Yan-yan
YY
Li
Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Lian-sheng
LS
Wang
Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Xin-zheng
XZ
Lu
D001281:Atrial Fibrillation / Q000235:genetics*; D002681:China; D006801:Humans; D011110:Polymorphism, Genetic; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics*
C489622:KCNE1 protein, human; D024642:Potassium Channels, Voltage-Gated