Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities.
Two new cucurbitane glycosides, hemslepenside A (1) and 16,25-O-diacetyl-cucurbitacin F-2-O-β-d-glucopyranoside (3), one new cucurbitacin, 16-O-acetyl-cucurbitacin F (2), along with three known cucurbitane compounds, were isolated from the roots of Hemsleya penxianensis. The structures of 1-6 were established on the basis of extensive spectroscopic and chemical methods. The isolated compounds were evaluated for their cytotoxic activities against different three human cancer cell lines, with IC50 values in the low microgram range.
Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China; School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
Xiaoting
X
Xu
Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
Hong
H
Bai
Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
Ling
L
Zhou
Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
Zhipeng
Z
Deng
Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
Hao
H
Zhong
Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
Zhongyu
Z
Wu
Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China. Electronic address: yao_imm@163.com.
Qingqiang
Q
Yao
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D019662:Cucurbitaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D018517:Plant Roots / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D014315:Triterpenes; C514277:cucurbitane
Cucurbitane triterpenoids; Cytotoxic activities; Hemsleya penxianensis