A hypothesis: hydrogen sulfide might be neuroprotective against subarachnoid hemorrhage induced brain injury.
Gases such as nitric oxide (NO) and carbon monoxide (CO) play important roles both in normal physiology and in disease. Recent studies have shown that hydrogen sulfide (H2S) protects neurons against oxidative stress and ischemia-reperfusion injury and attenuates lipopolysaccharides (LPS) induced neuroinflammation in microglia, exhibiting anti-inflammatory and antiapoptotic activities. The gas H2S is emerging as a novel regulator of important physiologic functions such as arterial diameter, blood flow, and leukocyte adhesion. It has been known that multiple factors, including oxidative stress, free radicals, and neuronal nitric oxide synthesis as well as abnormal inflammatory responses, are involved in the mechanism underlying the brain injury after subarachnoid hemorrhage (SAH). Based on the multiple physiologic functions of H2S, we speculate that it might be a promising, effective, and specific therapy for brain injury after SAH.
Department of Neurology, Wendeng Center Hospital of Weihai, The Affiliated Hospital of Weifang Medical College, Weihai 264400, China.
Yong-Peng
YP
Yu
Department of Neurology, Wendeng Center Hospital of Weihai, The Affiliated Hospital of Weifang Medical College, Weihai 264400, China.
Xiang-Lin
XL
Chi
Department of Neurology, The Affiliated Hospital of the Medical College of Qingdao University, Shandong 266003, China.
Li-Jun
LJ
Liu
D000818:Animals; D001930:Brain Injuries / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D006862:Hydrogen Sulfide / Q000494:pharmacology / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000517:prevention & control*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
D018696:Neuroprotective Agents; D006862:Hydrogen Sulfide