[Plasma levels of anti-oxidant markers during general anesthesia--a comparison between remifentanil- and epidural-based anesthesia].
BACKGROUND
Anesthesia may influence oxidative stress responses to surgical stress during surgery. We performed a prospective study to investigate the impact of anesthesia on oxidative stress responses between patients receiving ropivacaine-based epidural anesthesia and patients receiving remifentanil-based general anesthesia


METHODS
Plasma levels of oxidative stress-related substances such as superoxide dismutase (SOD) and myeloperoxidase were measured during anesthesia in patients receiving ropivacaine-based epidural anesthesia (E group) and patients receiving remifentanil-based general anesthesia (R group).


RESULTS
SOD, which catalyzes the reduction of superoxide anions to hydrogen peroxide and has anti-oxidative effects, was significantly lower in E group at the end of surgery whereas the levels of myeloperoxydase were not different between the groups. Plasma levels of adrenaline and noradrenaline were significantly higher in R group than E groups after surgery.


CONCLUSIONS
Although activation of sympathetic nervous system was effectively inhibited by epidural anesthesia. SOD level was low in E group. Remifentanil might directly increase SOD, independent of sympathetic nervous system.
Kei
K
Enohata
Maiko
M
Hasegawa-Moriyama
Tamotsu
T
Kuniyoshi
Yuichi
Y
Kanmura
D000328:Adult; D000368:Aged; D000577:Amides; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D000779:Anesthetics, Local; D000975:Antioxidants / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007432:Intraoperative Period; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D009195:Peroxidase / Q000097:blood*; D010880:Piperidines; D000077208:Remifentanil; D000077212:Ropivacaine; D013482:Superoxide Dismutase / Q000097:blood*
D000577:Amides; D000779:Anesthetics, Local; D000975:Antioxidants; D015415:Biomarkers; D010880:Piperidines; D000077212:Ropivacaine; D009195:Peroxidase; D013482:Superoxide Dismutase; D000077208:Remifentanil; D009638:Norepinephrine; D004837:Epinephrine