Palladium-catalyzed carbonylation of o-iodoanilines for synthesis of isatoic anhydrides.
A novel palladium-catalyzed oxidative double carbonylation of o-iodoanilines for the synthesis of isatoic anhydrides has been developed. The reaction employs readily available o-iodoanilines as the starting materials and proceeds under mild conditions. For extension, palladium-catalyzed oxidative carbonylation of anthranilic acids was developed for the synthesis of substituted isatoic anhydrides in high to excellent yields.
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry and Materials Science, Northwest University , Xi'an 710069, P. R. China.
Sha
S
Gao
Ming
M
Chen
Mi-Na
MN
Zhao
Wei
W
Du
Zhi-Hui
ZH
Ren
Yao-Yu
YY
Wang
Zheng-Hui
ZH
Guan