Serotonergic, noradrenergic and dopaminergic markers are related to cognitive function in adults with 22q11 deletion syndrome.
Patients with 22q11 deletion syndrome (22q11DS) have a high prevalence of psychiatric disorders and intellectual disability. At present the neurobiology underlying psychopathology in 22q11DS is still not understood. In the present study, we analyzed urinary serotonergic, dopaminergic and noradrenergic markers in 67 adults with 22q11DS. Levels of serotonin and the catecholamine metabolite homovanillic acid were significantly lower in the 22q11DS subjects compared to healthy controls. Within the 22q11DS group, levels of dopamine, homovanillic acid, norepinephrine, vanillyl mandelic acid and serotonin positively correlated with Full Scale Intelligence Quotient scores. Our results suggest that cognitive deficits in 22q11DS are associated with abnormal function of several neurotransmitters.
Koraalgroup, MFCG,Heel,The Netherlands.
Laurens J M
LJ
Evers
Governor Kremers Centre, Maastricht University Medical Centre,Maastricht,The Netherlands.
Leopold M G
LM
Curfs
Department Clinical Genetics,Maastricht University Medical Centre,Maastricht,The Netherlands.
Jaap A
JA
Bakker
Ipse de Bruggen, Centre for People with intellectual disability,Zwammerdam,The Netherlands.
Erik
E
Boot
Department of Psychiatry,Academic Medical Centre, University of Amsterdam,Amsterdam,The Netherlands.
Fabiana
F
da Silva Alves
Department of Genetic Metabolic Disorders,AMC,Amsterdam,The Netherlands.
Nico
N
Abeling
Department Clinical Genetics,Maastricht University Medical Centre,Maastricht,The Netherlands.
Jörgen
J
Bierau
Department of Psychiatry and Psychology,School for Mental Health and Neuroscience MHeNS, Maastricht University Medical Centre,Maastricht,The Netherlands.
Marjan
M
Drukker
Department of Psychiatry and Psychology,School for Mental Health and Neuroscience MHeNS, Maastricht University Medical Centre,Maastricht,The Netherlands.
Therese A M J
TA
van Amelsvoort
D058165:22q11 Deletion Syndrome / Q000150:complications* / Q000652:urine*; D000328:Adult; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000150:complications* / Q000652:urine*; D004298:Dopamine / Q000652:urine*; D005260:Female; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D009638:Norepinephrine / Q000652:urine*; D012701:Serotonin / Q000652:urine*; D014642:Vanilmandelic Acid / Q000652:urine; D055815:Young Adult
D015415:Biomarkers; D012701:Serotonin; D014642:Vanilmandelic Acid; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid