Microbial growth in neonatal intravenous fat emulsion administered over 12 versus 24 hours.
OBJECTIVE
To determine whether an extended infusion time (24 hours) of intravenous fat emulsion is associated with an increase in microbial growth, versus a shorter infusion time (12 hours).


METHODS
Samples were collected from intravenous fat emulsions (n=132), from intravenous fat emulsions prepared in the current 24-hour infusion method (n=55), and from intravenous fat emulsions prepared in the twice-daily (12-hour infusion) method (n=55). In addition, samples were collected from pharmacy (n=22) to test for possible contamination.


RESULTS
No growth was observed in either arm of the study.


CONCLUSIONS
Current Kern Medical Center policy of preparation and administration of neonatal intensive care unit intravenous fat emulsion is safe and effective in regard to microbial growth.
Department of Clinical Pharmacy, Kern Medical Center, Bakersfield, California.
Bethany M
BM
Dedonato
Department of Clinical Pharmacy, Kern Medical Center, Bakersfield, California.
Lisa I
LI
Bickford
Department of Clinical Pharmacy, Kern Medical Center, Bakersfield, California.
Ryan J
RJ
Gates
infection; intravenous fat emulsion; lipid; microbial; neonatal