Determination of the solubility of crystalline low molar mass compounds in polymers by differential scanning calorimetry.
A mathematical equation has been derived to calculate the liquidus for a binary system consisting of an amorphous polymer and a crystalline low molar mass compound. The experimental input to this equation is an interaction enthalpy, which is derived from the variation of the melting enthalpy with composition in differential scanning calorimetry (DSC) experiments. The predictive power of the equation has been tested with mixtures of acetylsalicylic acid, carbamazepine, or intraconazole with poly(ethylene glycol) as well as mixtures of carbamazepine with poly(acrylic acid), poly(hydroxystyrene), or poly(vinylpyrrolidone). It has been confirmed that the evaluation of the melting enthalpy in DSC is a suitable method to identify the preferred solute-polymer combinations for thermodynamically stable molecular dispersions.
Solvias AG, Department for Solid-State Development, Römerpark 2, 4303, Kaiseraugst, Switzerland.
Timo
T
Rager
D002152:Calorimetry, Differential Scanning / Q000379:methods*; D003460:Crystallization; D008970:Molecular Weight; D011108:Polymers / Q000737:chemistry*; D012995:Solubility
D011108:Polymers
amorphous; calorimetry (DSC); liquidus; mathematical model; polymeric drug carrier; solid dispersion; solid solution; solubility; stability; thermodynamics