[Ceftaroline fosamil in community-acquired and nosocomial pneumonia].
Community-acquired pneumonia (CAP) is a common infection in developed countries and causes a large number of hospital admissions and deaths. In recent years, the incidence of this disease has increased, caused by progressive population aging. Following the introduction of the conjugate vaccine against Streptococcus pneumoniae, there have been significant epidemiological changes that require close monitoring because of the possible emergence of new patterns of resistance. This article aims to review the role of ceftaroline fosamil, a new parenteral cephalosporin with antibacterial activity against Gram-negative and Gram-positive pathogens, in the treatment of pneumonia. Several in vitro and in vivo studies have shown the efficacy of ceftaroline fosamil against penicillin-resistant S. pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). Additionally, ceftaroline has shown similar efficacy and safety to ceftriaxone in the treatment of community-acquired pneumonia with severe prognosis (prognostic severity index III and IV) in two phase III clinical trials. Although a non-inferiority design was used for these clinical trials, some data suggest a superior efficacy of ceftaroline, with earlier clinical response and higher cure rate in infections caused by S. pneumoniae, making this drug particularly interesting for critically-ill patients admitted to the intensive care unit. Ceftaroline may also be considered for empirical and directed treatment of MRSA pneumonia.
Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas, Hospital Universitario Mutua de Terrassa, Terrassa, Barcelona, España; Universidad Internacional de Catalunya, Valencia, España. Electronic address: ecalbo@mutuaterrassa.es.
Esther
E
Calbo
Servicio de Medicina Intensiva, Hospital Universitario Dr. Peset, Valencia, España; Coordinador del Programa Interdisciplinar de Atención en la Sepsis Grave, Hospital Universitario Dr. Peset, Valencia, España.
Rafael
R
Zaragoza
D000818:Animals; D002511:Cephalosporins / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D017714:Community-Acquired Infections / Q000188:drug therapy; D003428:Cross Infection / Q000188:drug therapy*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy; D011023:Pneumonia, Staphylococcal / Q000188:drug therapy; D013296:Streptococcus pneumoniae; D000097583:Ceftaroline
D002511:Cephalosporins; D000097583:Ceftaroline
Ceftarolina fosamil; Ceftaroline fosamil; Methicillin resistant Staphylococcus aureus; Neumonía; Penicillin resistance; Pneumonia; Resistencia a la penicilina; Staphylococcus aureus resistente a meticilina; Streptococcus pneumoniae