Seoritae extract reduces prostate weight and suppresses prostate cell proliferation in a rat model of benign prostate hyperplasia.
Seoritae is a type of black soybean that is known to have health-promoting effects due to its high isoflavone and anthocyanin contents. We evaluated whether Seoritae extract (SE) had beneficial effects on the reduction of prostate weight in a rat model of benign prostatic hyperplasia (BPH). BPH was induced by intramuscular injections of testosterone enanthate once a week for 5 weeks in Sprague-Dawley rats, and rats were treated with or without daily oral doses of SE during BPH induction. After 5 weeks, the oxidative stress (superoxide dismutase and 8-hydroxy-2-deoxyguanosine), apoptosis (caspase-3), and activity of 5-alpha reductase were evaluated in the serum and prostate. The SE treatment group showed a significant decrease in prostate weight, oxidative stress, apoptosis, and 5-alpha reductase activity compared to the nontreated BPH group. These results show that SE is effective in decreasing the weight and proliferation of the prostate, and suggest that SE may be an effective treatment for BPH.
Department of Urology, The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital, 222 Banpo-daero, Seocho-Gu, Seoul 137-701, Republic of Korea.
Hoon
0000-0003-0534-549X
H
Jang
Department of Urology, The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital, 222 Banpo-daero, Seocho-Gu, Seoul 137-701, Republic of Korea.
Woong-Jin
WJ
Bae
Department of Urology, The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital, 222 Banpo-daero, Seocho-Gu, Seoul 137-701, Republic of Korea.
Seung-Mo
SM
Yuk
Department of Urology, The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital, 222 Banpo-daero, Seocho-Gu, Seoul 137-701, Republic of Korea.
Dong-Seok
DS
Han
Department of Urology, The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital, 222 Banpo-daero, Seocho-Gu, Seoul 137-701, Republic of Korea.
U-Syn
US
Ha
Korea Bio Medical Science Institute, Prime Tower 1st Floor Sinmunno 2-ga, Jongno-gu, Seoul 110-062, Republic of Korea.
Seong-Yeon
SY
Hwang
The Catholic Agro-Medical Center, The Catholic University of Korea, Seoul St. Mary's Hospital, 222 Banpo-daero, Seocho-Gu, Seoul 137-701, Republic of Korea.
Shin-Hee
SH
Yoon
Department of Urology, The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital, 222 Banpo-daero, Seocho-Gu, Seoul 137-701, Republic of Korea.
Sae-Woong
SW
Kim
Department of Urology, The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital, 222 Banpo-daero, Seocho-Gu, Seoul 137-701, Republic of Korea ; The Catholic University of Korea, Uijeongbu, St. Mary's Hospital 271, Cheon Bo-Ro, Uijeongbu-Si, Gyeonggi-Do 480-717, Republic of Korea.
Chang-Hee
CH
Han