Polyamine blockade promotes antitumor immunity.
The levels of polyamines are elevated in neoplastic lesions as compared with normal tissues, and cancer cells tend to manifest a robust dependence on these compounds for proliferation and survival. We have recently demonstrated that a novel approach to polyamine depletion suppresses tumor growth in a T cell-dependent manner, highlighting a poorly appreciated role of polyamines as strong modulators of antitumor immune responses.
Lankenau Institute for Medical Research; Wynnewood, PA USA.
Candace S
CS
Hayes
Aminex Therapeutics, Inc.; Kenmore, WA USA.
Mark R
MR
Burns
Lankenau Institute for Medical Research; Wynnewood, PA USA.
Susan K
SK
Gilmour
difluoromethylornithine; immunomodulation; polyamines; transport inhibitor; tumor microenvironment