Aggravation of hypertriglyceridemia and acute pancreatitis in a bipolar patient treated with quetiapine.
Pancreatitis is a very rare adverse effect of quetiapine treatment, with only 5 cases of quetiapine-associated pancreatitis reported in the English literature to date. Herein, we report one patient who developed severe hypertriglyceridemia (>1000 mg/dL) after quetiapine administration, resulting in acute pancreatitis. An analysis of the underlying pathogenic mechanisms and a review of relevant literature are also presented. Clinicians should be aware of the potentially life-threatening metabolic disturbances and/or pancreatitis associated with quetiapine therapy.
Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Li-Syue
LS
Liou
Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Yi-Jen
YJ
Hung
Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chang-Hsun
CH
Hsieh
Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Fone-Ching
FC
Hsiao
D000208:Acute Disease; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology*; D003987:Dibenzothiazepines / Q000627:therapeutic use*; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy* / Q000523:psychology*; D010195:Pancreatitis / Q000188:drug therapy* / Q000523:psychology*; D000069348:Quetiapine Fumarate
D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate
Quetiapine; hypertriglyceridemia; pancreatitis