Nanoethosomes mediated transdermal delivery of vinpocetine for management of Alzheimer's disease.
OBJECTIVE
To develop and statistically optimize nanoethosomal formulation for transdermal delivery of vinpocetine as an anti-Alzheimer's drug.


METHODS
Box-Behnken experimental design was applied for optimization of nanoethosomes. The independent variables were phospholipid (X1), Tween 80 (X2) and Ethanol (X3) while entrapment efficiency (Y1), particle sizes (Y2), elasticity (Y3) and flux (Y4) were the dependent variables.


CONCLUSIONS
Optimized nanoethosomal vinpocetine formulation with mean particle size 50.57 ± 26.11 nm showed 97.51 ± 0.86% entrapment efficiency, achieved mean transdermal flux 925.60 ± 39.80 µg/cm2/h and elasticity of 86.61 ± 2.88. Ex-vivo study of nanoethosomal formulation showed a significant increase flux and entrapment efficiency compared with control vinpocetine solution. Our results suggest that nanoethosome is an efficient carrier for transdermal delivery of vinpocetine as compared to its oral form.
a Department of Pharmaceutics, Faculty of Pharmacy , Hamdard University , New Delhi , India.
Atefeh Afshar
AA
Moghaddam
a Department of Pharmaceutics, Faculty of Pharmacy , Hamdard University , New Delhi , India.
Mohd
M
Aqil
a Department of Pharmaceutics, Faculty of Pharmacy , Hamdard University , New Delhi , India.
Farhan J
FJ
Ahmad
a Department of Pharmaceutics, Faculty of Pharmacy , Hamdard University , New Delhi , India.
Mushir M
MM
Ali
a Department of Pharmaceutics, Faculty of Pharmacy , Hamdard University , New Delhi , India.
Yasmin
Y
Sultana
a Department of Pharmaceutics, Faculty of Pharmacy , Hamdard University , New Delhi , India.
Asgar
A
Ali
Alzheimer’s; Box–Behnken design; nanoethosome; transdermal; vinpocetine