Psoriasis and risk of venous thromboembolism: a systematic review and meta-analysis.
BACKGROUND
Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been shown to increase venous thromboembolism (VTE) risk but the data on psoriasis is unclear.


METHODS
We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio or standardized incidence ratio comparing VTE risk in patients with psoriasis vs. non-psoriasis participants. Pooled risk ratio and 95% confidence intervals were calculated using a random effect, generic inverse variance method.


RESULTS
Four studies were identified and included in our data analysis. The pooled risk ratio of VTE in patients with psoriasis was 1.46 (95% CI, 1.29-1.66). The statistical heterogeneity of this meta-analysis was high with an I(2) of 86%.


CONCLUSIONS
Our study demonstrated a statistically significant increased VTE risk among patients with psoriasis.
From the Department of Medicine, Faculty of Medicine Siriraj Hospital, Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang road, Bangkok, 10700, Thailand and Department of Cardiology, University of Utah, School of Medicine, 30 N 1900 E, Salt Lake City, Utah, 84132, USA patompong.ungprasert@bassett.org.
Patompong
P
Ungprasert
From the Department of Medicine, Faculty of Medicine Siriraj Hospital, Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang road, Bangkok, 10700, Thailand and Department of Cardiology, University of Utah, School of Medicine, 30 N 1900 E, Salt Lake City, Utah, 84132, USA.
Anawin
A
Sanguankeo
From the Department of Medicine, Faculty of Medicine Siriraj Hospital, Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang road, Bangkok, 10700, Thailand and Department of Cardiology, University of Utah, School of Medicine, 30 N 1900 E, Salt Lake City, Utah, 84132, USA.
Sikarin
S
Upala
From the Department of Medicine, Faculty of Medicine Siriraj Hospital, Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang road, Bangkok, 10700, Thailand and Department of Cardiology, University of Utah, School of Medicine, 30 N 1900 E, Salt Lake City, Utah, 84132, USA.
Promporn
P
Suksaranjit
D003625:Data Collection / Q000592:standards*; D006801:Humans; D064887:Observational Studies as Topic; D016017:Odds Ratio; D011565:Psoriasis / Q000150:complications*; D054556:Venous Thromboembolism / Q000453:epidemiology*