Effects of three Commercial Mouth Rinses on the Cultured Fibroblasts: An in Vitro Study.
BACKGROUND
An ideal antimicrobial agent should have minimal cytotoxic effect to host cells.


OBJECTIVE
The aim of this study was to determine the cytotoxic effect of three commercial mouthwashes (Chlorhexidine, Persica and Irsha) on the cultured fibroblasts.


METHODS
For determining the cytotoxic effect of Irsha, Chlorhexidine and Persica, uninfected cells were grown in the absence and presence of various concentration (2,4,8,16,32,64,128) of these mouth washes for 1, 2, 3 and 4 days.


RESULTS
In this study, three mouth washes show cytotoxic effect on the cultured cells, at commercially available concentration and even diluted and Irsha was found to be the most toxic one. Cytotoxicity of three mouthwashes was reduced with decreasing concentration.
Dept. of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
J
J
Ghabanchi
Dept. of Microbiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
A
A
Moattari
Dept. of Prosthodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
R
R
Darafshi
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
A
A
Andisheh Tadbir
Dept. of Periodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
H
H
Khorshidi
Undergraduate Student, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
M
M
Shakib
Chlorhexidine; Cytotoxicity; Irsha; Mouthwash; Persica