Sonic hedgehog causes mural cells to jump 'n' run.
In this issue of Blood, Yao and colleagues report that the morphogen sonic hedgehog (Shh) is driven by platelet-derived growth factor B (PDGF-BB) in vascular smooth muscle cells, contributing to vessel maturation in an autocrine manner.
GOETHE UNIVERSITY HOSPITAL FRANKFURT.
Stefan
S
Liebner
D000818:Animals; D000077214:Becaplermin; D002465:Cell Movement / Q000502:physiology*; D053823:Hedgehog Proteins / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D020574:Proto-Oncogene Proteins c-sis / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D053823:Hedgehog Proteins; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin