Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system.
The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system (CNS) malfunction has triggered intensive investigation of the biological roles played by DISC1, with the hope that this may shed new light on the pathobiology of psychiatric disease. Such work has ranged from investigations of animal behavior to detailed molecular-level analysis of the assemblies that DISC1 forms with other proteins. Here, we discuss the evidence for a role of DISC1 in synaptic function in the mammalian CNS.
School of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol, UK; Institute of Biomedical and Clinical Sciences, University of Exeter, The Hatherley Building, Prince of Wales Road, Exeter, EX4 4PS, UK.
Andrew D
AD
Randall
Mai
M
Kurihara
Nicholas J
NJ
Brandon
Jon T
JT
Brown
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism / Q000503:physiopathology*; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D001523:Mental Disorders / Q000235:genetics / Q000503:physiopathology*; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D009435:Synaptic Transmission
C412476:DISC1 protein, human; D009419:Nerve Tissue Proteins
elecrtophysiology; neurophysiology; psychiatric genetics; synaptic physiology; synaptic plasticity