Structure determination of two new indole-diterpenoids from Penicillium sp. CM-7 by NMR spectroscopy.
Two new indole-diterpenoids 4b-deoxy-1'-O-acetylpaxilline (1) and 4b-deoxypenijanthine A (2) were isolated from the fermentation broth and the mycelia of the soil fungus Penicillium sp. CM-7, along with three known structurally related compounds, 1'-O-acetylpaxilline (3), paspaline (4) and 3-deoxo-4b-deoxypaxilline (5). The structures of compounds 1 and 2 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data.
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Yu-Hong
YH
Zhang
Sheng-Dong
SD
Huang
Hua-Qi
HQ
Pan
Xi-Qing
XQ
Bian
Zai-Ying
ZY
Wang
Ai-Hong
AH
Han
Jiao
J
Bai
D004224:Diterpenes / Q000032:analysis / Q000737:chemistry*; D007211:Indoles / Q000032:analysis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008968:Molecular Conformation; D010407:Penicillium / Q000145:classification* / Q000378:metabolism*; D013045:Species Specificity
D004224:Diterpenes; D007211:Indoles
13C NMR; 1H NMR; Indole-diterpenoids; NMR; Penicillium sp