Construction of the N1-C3 linkage stereogenic centers by catalytic asymmetric amination reaction of 3-bromooxindoles with indolines.
The catalytic asymmetric amination reaction of 3-bromooxindoles with indolines for the construction of the N1-C3 linkage stereogenic centers has been realized for the first time. Moreover, the racemic substrates (3-substituted indolines) were also applicable under the same chiral conditions. The newly developed method conveniently led to a formal synthesis of (+)-psychotrimine.
School of Life Sciences, Key Laboratory of Preclinical Study for New Drug of Gansu Province, Lanzhou University Lanzhou 730000, P.R. China.
Hailong
H
Zhang
Hong
H
Kang
Liang
L
Hong
Weiping
W
Dong
Guolin
G
Li
Xin
X
Zheng
Rui
R
Wang
D000586:Amination; D002384:Catalysis; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D013237:Stereoisomerism
D026121:Indole Alkaloids; D007211:Indoles; D000078183:Oxindoles; C503380:psychotrimine; C022960:2-oxindole; C057812:indoline