Severe acute radiation dermatitis in a patient with argyria.
Argyria is a rare cutaneous condition due to dermal silver deposition leading to irreversible blue-grey discoloration. Acute radiation dermatitis (RD) is an expected toxicity in patients undergoing radiotherapy but it is unknown to what extent argyria affects the onset and severity of RD. We report a patient with argyria treated with concurrent chemoradiotherapy for Merkel cell carcinoma who experienced an unexpectedly brisk and severe RD during treatment. Possible mechanisms for this interaction are considered.
Radiation Oncology, Mater Centre, South Brisbane, QLD 4101, Australia ; University of Queensland, St Lucia, QLD 4067, Australia.
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Gorayski
Radiation Oncology, Mater Centre, South Brisbane, QLD 4101, Australia ; University of Queensland, St Lucia, QLD 4067, Australia.
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Pinkham
Department of Dermatology, Mater Adults Hospital, South Brisbane, QLD 4101, Australia.
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Muir
Radiation Oncology, Mater Centre, South Brisbane, QLD 4101, Australia ; University of Queensland, St Lucia, QLD 4067, Australia ; Department of Radiation Oncology, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia.
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Pullar