Germline polymorphisms in RNF31 regulate linear ubiquitination and oncogenic signaling.
A new study proposes that the cancerous behavior of B cells in a subtype of diffuse large B-cell lymphoma is caused by excessive activity of the linear ubiquitin chain assembly complex (LUBAC) complex, which underlies abnormal NF-κB signaling. Two rare germline single-nucleotide polymorphisms in the RNF31 gene have been identified as being responsible. The use of a small inhibiting peptide may downregulate the abnormal LUBAC activity and counteract neoplastic cell growth.
Institute of Biochemistry II, Goethe University, School of Medicine, Frankfurt am Main, Germany.
Paolo
P
Grumati
Ivan
I
Dikic
D018095:Germ-Line Mutation; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics* / Q000378:metabolism*
D014157:Transcription Factors; C504507:RBCK1 protein, human; C558338:RNF31 protein, human; D044767:Ubiquitin-Protein Ligases