Interleukin-23 receptor polymorphisms are associated with Alzheimer's disease in Han Chinese.
Inhibition of interleukin-23 (IL-23) signaling was reported to reduce AD pathology, and IL-23 receptor gene (IL23R) which encodes IL-23 receptor may represent a candidate susceptibility gene for AD. Here, we conducted a case-control association study to assess the effect of IL23R genetic polymorphisms on the risk of AD in a Northern Han Chinese population. Two tag functional single polymorphisms (SNPs), rs10889677 and rs1884444 were selected, and their associations with AD risk factors were assessed in 1133 AD patients and 1156 matched controls. Our association analysis showed that C allele of rs10889677 was significantly associated with decreased AD risk even after adjusting for age, gender, and apolipoprotein E gene (APOE) ɛ4 status. The G allele of rs1884444 polymorphism is significantly associated with a higher risk of AD in APOE ɛ4 carriers. Our results demonstrate that IL23R genetic polymorphisms are associated with AD in a Northern Han Chinese population.
Department of Neurology, Dalian Medical University, Qingdao Municipal Hospital, China.
Ying
Y
Liu
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China; Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China. Electronic address: yu-jintai@163.com.
Jin-Tai
JT
Yu
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.
Wei
W
Zhang
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.
Yu
Y
Zong
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.
Rui-Chun
RC
Lu
Department of Neurology, Dalian Medical University, Qingdao Municipal Hospital, China.
Jing
J
Zhou
Department of Neurology, Dalian Medical University, Qingdao Municipal Hospital, China; Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China; Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China. Electronic address: dr.tanlan@163.com.
Lan
L
Tan
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000208:ethnology* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D002681:China / Q000208:ethnology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*
D001057:Apolipoproteins E; C515500:IL23R protein, human; D018123:Receptors, Interleukin
Alzheimer's disease; Association study; IL23R; Interleukin-23; Polymorphism