Antioxidant and toxicological effects elicited by alpha-lipoic acid in aquatic organisms.
Lipoic acid (LA) is a disulfide-containing compound derived from octanoic acid that is synthesized in mitochondria. This molecule acts as a co-factor for mitochondrial enzymes that catalyze oxidative decarboxylation reactions. Several antioxidant properties of LA enable it to be considered as an "ideal antioxidant", having diverse benefits that allow it to deal with environmental or biological stress. Some of the effects induced by LA in aquatic organisms render it suitable for use in aquaculture. However, it is necessary to determine the appropriate dose(s) to be used with different species and even organs to maximize the beneficial antioxidant and detoxifying effects and to minimize the pro-oxidant toxic effects. This review analyzes and compiles existing data from aquatic organisms in which both benefits and drawbacks of LA have been described.
Programa de Pós-Graduação em Aquicultura, Universidade Federal do Rio Grande - FURG, Av. Itália km 8, Rio Grande, RS, C.P. 474, CEP 96.200-970, Brasil.
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Kütter
Programa de Pós-Graduação em Aquicultura, Universidade Federal do Rio Grande - FURG, Av. Itália km 8, Rio Grande, RS, C.P. 474, CEP 96.200-970, Brasil; Instituto de Oceanografia (IO), Laboratório de Patologia e Imunologia de Organismos Aquáticos, FURG, Brasil.
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Romano
Programa de Pós-Graduação em Ciências Fisiológicas - Fisiologia Animal Comparada, Universidade Federal do Rio Grande - FURG, Av. Itália km 8, Rio Grande, RS, C.P. 474, CEP 96.200-970, Brasil; Instituto de Ciências Biológicas (ICB), FURG, Brasil.
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Ventura-Lima
Programa de Pós-Graduação em Aquicultura, Universidade Federal do Rio Grande - FURG, Av. Itália km 8, Rio Grande, RS, C.P. 474, CEP 96.200-970, Brasil; Instituto de Oceanografia (IO), Laboratório de Nutrição de Organismos Aquáticos, FURG, Brazil.
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Tesser
Programa de Pós-Graduação em Aquicultura, Universidade Federal do Rio Grande - FURG, Av. Itália km 8, Rio Grande, RS, C.P. 474, CEP 96.200-970, Brasil; Programa de Pós-Graduação em Ciências Fisiológicas - Fisiologia Animal Comparada, Universidade Federal do Rio Grande - FURG, Av. Itália km 8, Rio Grande, RS, C.P. 474, CEP 96.200-970, Brasil; Instituto de Ciências Biológicas (ICB), FURG, Brasil. Electronic address: josemmonserrat@pq.cnpq.br.
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Monserrat
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity*; D059001:Aquatic Organisms / Q000502:physiology*; D008658:Inactivation, Metabolic; D008063:Thioctic Acid / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity*
D000975:Antioxidants; D008063:Thioctic Acid
Antioxidant status; Aquatic organisms; Detoxification reactions; Dihydrolipoic acid; Lipoate