Personalized platelet transfusions: one step closer to the clinic.
In this issue of Cell Stem Cell, Nakamura et al. (2014) use human pluripotent stem cells to generate immortalized megakaryocyte progenitor cell lines that can be cryopreserved, expanded in vitro, and induced to undergo terminal maturation and platelet release. This strategy advances efforts to produce clinically relevant numbers of tissue-culture-derived platelets for transfusion therapies.
Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Ji-Yoon
JY
Noh
Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Mitchell J
MJ
Weiss
Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: poncz@email.chop.edu.
Mortimer
M
Poncz
D000818:Animals; D001792:Blood Platelets / Q000166:cytology*; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D008533:Megakaryocytes / Q000166:cytology*; D013921:Thrombocytopenia / Q000473:pathology*