Oxidative stress and nasal polyposis: does it affect the severity of the disease?
BACKGROUND
Nasal polyposis (NP) is a chronic inflammatory disease and the waste products of this inflammation are reactive oxygen species composed of free radicals. Changes in oxidative status have already been revealed in NP. The aim of this study was to investigate the effect of oxidative status to the severity of the disease and the quality of life.


METHODS
The study group included 24 patients with NP and 20 controls. The Turkish version of the Rhinosinusitis Disability Index, visual analog scale (VAS), polyp stage, computed tomography (CT) score, and the eosinophilic cationic protein (ECP) levels in nasal lavage (NAL) fluid were used to assess the severity of the disease. Malondialdehyde, nitric oxide (NO), and the total antioxidant status (TAS) levels in NAL fluids were measured representing the oxidative stress.


RESULTS
NO values were correlated with nasal congestion (p = 0.031). TAS values were correlated with nasal obstruction (p = 0.039). ECP values showed correlation with all the nasal obstruction (p = 0.003), congestion (p = 0.009), rhinorrhea (p = 0.009), and VAS scores (p = 0.039).


CONCLUSIONS
In NP, ECP levels detected in NAL fluid were significantly high and were correlated with the severity of the disease. Moreover, the severity of oxidative stress, in the forms of TAS and NO, is significantly correlated with the severity of the nasal obstruction and congestion, respectively.
Department of Otolaryngology, Baskent University, Faculty of Medicine, Konya, Turkey.
Ozgul
O
Topal
Sevsen
S
Kulaksızoglu
Selim S
SS
Erbek
D000328:Adult; D000368:Aged; D018450:Disease Progression; D047150:Eosinophil Cationic Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D009298:Nasal Polyps / Q000276:immunology / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011788:Quality of Life; D017382:Reactive Oxygen Species / Q000378:metabolism; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D014421:Turkey
D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D008315:Malondialdehyde; D047150:Eosinophil Cationic Protein