Ibuprofen associated acute vanishing bile duct syndrome and toxic epidermal necrolysis in an infant.
Acute vanishing bile duct syndrome, a rare but rapidly progressive destruction of the intrahepatic bile ducts with unknown pathogenesis, is most often a drug- or toxin-related. Toxic epidermal necrolysis is a serious dermatologic condition and a potentially life threatening disease, which is drug or infection induced. Ibuprofen associated acute vanishing bile duct syndrome and toxic epidermal necrolysis have not been reported previously in infants. We report a 7-month-old infant with ibuprofen associated toxic epidermal necrolysis, followed by severe and rapidly progressive vanishing bile duct syndrome. She recovered totally with supportive care.
Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea. ; Medical Research Institute, Pusan National University Hospital, Busan, Korea.
Hye-young
HY
Kim
Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea.
Hea Kyoung
HK
Yang
Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea. ; Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Korea.
Seong Heon
SH
Kim
Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea. ; Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Korea.
Jae Hong
JH
Park
D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D007223:Infant; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis* / Q000209:etiology*
D007052:Ibuprofen
Acute vanishing bile duct syndrome; infant; toxic epidermal necrolysis