Extramedullary relapse of the AML transformed from MDS following auto-HSCT: a case report.
The treatment for AML (Acute myeloid/myelogenous leukemia) transformed from MDS (myelodysplastic syndrome) is difficult and controversial clinically, especially in elder patients. In this case report, we diagnosed a 59-year-old female patient with AML-M2a transformed form MDS which might be caused by her chemotherapy for mastocarcinoma. After achieving complete remission (CR) through combined chemotherapy, autologous peripheral blood stem cell transplantation (auto-PBSCT) was attempted. Following auto-HSCT, marrow showed continuous CR but the patient later developed extramedullary bone-infiltration relapse. Then local radiotherapy has been applied, and the patient now has prolonged survival. This is the first (or a successful) case report of auto-HSCT in an elderly patient with AML transformed from MDS.
Department of Hematology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China, wangj5768@yahoo.com.cn.
Jin
J
Wang
Yu
Y
Liu
Xu
X
Zhou
Zheng
Z
Li
Xiang
X
Li
Hualiang
H
Xiao
D002471:Cell Transformation, Neoplastic; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000473:pathology*; D012008:Recurrence; D014182:Transplantation, Autologous