Emerging genetic basis of osteochondritis dissecans.
Genome-wide association studies (GWAS) provide an unbiased approach in the identification of genes that increase the risk for osteochondritis dissecans (OCD). Recent GWAS in humans, horses, and pigs are reviewed and genes identified. The identified genes tended to cluster with respect to function and biologic processes. GWAS in humans are a critical next step in the effort to provide a better understanding of the causes of OCD, which will, in turn, allow preventive strategies for treatment of adolescents and young adults who are at risk for the development of degenerative joint disease due to the effects of OCD.
Department of Biological Sciences, Biomolecular Research Center, Musculoskeletal Research Institute, Boise State University, 1910 University Drive, Boise, ID 83725, USA.
J Tyler
JT
Bates
University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA.
John C
JC
Jacobs
St. Luke's Sports Medicine, St. Luke's Health System, St. Luke's Children's Hospital, 600 North Robbins Road, Suite 400, Boise, ID 83702, USA; Department of Orthopedics, University of Utah, 590 Wakara Way, Salt Lake City, UT 84108, USA.
Kevin G
KG
Shea
Department of Biological Sciences, Biomolecular Research Center, Musculoskeletal Research Institute, Boise State University, 1910 University Drive, Boise, ID 83725, USA. Electronic address: joxford@boisestate.edu.
Julia Thom
JT
Oxford
D000818:Animals; D005109:Extracellular Matrix / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006734:Horse Diseases / Q000235:genetics; D006736:Horses / Q000235:genetics; D006801:Humans; D010008:Osteochondritis Dissecans / Q000235:genetics*; D013552:Swine / Q000235:genetics; D013553:Swine Diseases / Q000235:genetics
Equine; Genome-wide association study; Human; Osteoarthritis; Osteochondritis dissecans; Osteochondrosis; Single nucleotide polymorphism; Swine