Dexmedetomidine sedation with and without midazolam for third molar surgery.
Twenty-four patients were randomly divided into 2 groups. Intraoperatively, one group received a continuous intravenous infusion of dexmedetomidine alone, whereas the other received a continuous dexmedetomidine infusion plus a small dose of midazolam. Early measurements of patient anxiety and psychomotor performance were lower in patients who had received midazolam. This difference was not seen later in the appointment. An amnesic effect was observed in those patients who received midazolam. This effect, however, did not translate into increased patient satisfaction in the group receiving midazolam. Our findings suggest a prolonged discharge time for patients who had been given midazolam that may be clinically significant. Overall, dexmedetomidine showed an unpredictable sedative response and may be less practical than more common alternatives for oral surgery procedures.
Nationwide Children's Hospital, Columbus, Ohio, and.
Megann K
MK
Smiley
Simon R
SR
Prior
D000293:Adolescent; D000328:Adult; D000762:Anesthesia Recovery Period; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001364:Awareness / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D056805:Consciousness Monitors; D016854:Dental Anxiety / Q000145:classification / Q000523:psychology; D020927:Dexmedetomidine / Q000008:administration & dosage*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D007430:Intraoperative Care; D008297:Male; D008568:Memory / Q000187:drug effects; D008874:Midazolam / Q000008:administration & dosage / Q000627:therapeutic use*; D008964:Molar, Third / Q000601:surgery*; D010092:Oximetry; D017060:Patient Satisfaction; D011597:Psychomotor Performance / Q000187:drug effects; D014081:Tooth Extraction / Q000379:methods*; D055815:Young Adult
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D008874:Midazolam