Short-term outcomes after incontinent conduit for gynecologic cancer: comparison of ileal, sigmoid, and transverse colon.
OBJECTIVE
The aim of this study is to estimate the overall rates of significant incontinent conduit-related complications and compare rates between conduit types.


METHODS
This was a retrospective review of 166 patients who underwent incontinent urinary diversion from April 1993 through April 2013. Patients were categorized by conduit type-ileal, sigmoid colon, and transverse colon. Significant conduit-related complications were assessed at 30 and 90days after surgery. Significant conduit-related complication was defined as any of the following: ureteral stricture, conduit leak, conduit obstruction, conduit ischemia, ureteral anastomotic leak, stent obstruction requiring intervention via interventional radiology procedure or reoperation, and renal failure.


RESULTS
A total of 166 patients underwent formation of an incontinent urinary conduit, most commonly during exenteration for gynecologic malignancy. There were 129 ileal, 11 transverse colon, and 26 sigmoid conduits. The overall significant conduit-related complication rate within 30days was 15.1%. Complication rates for ileal, transverse and sigmoid conduits were 14.7%, 0%, and 23.1%, respectively (Fisher's exact test, p=0.24). By 90days, the Kaplan-Meier estimated rates of significant complications were 21.8% overall, and 22.3%, 0%, and 28.9%, respectively, by conduit type (log-rank test, p=0.19). The most common significant conduit-related complications were conduit or ureteral anastomotic leaks and conduit obstructions. By 1 and 2years following surgery, the Kaplan-Meier estimated overall rate of significant conduit-related complication increased to 26.5% and 30.1%, respectively.


CONCLUSIONS
Our study suggests that there are multiple appropriate tissue sites for use in incontinent conduit formation, and surgical approach should be individualized. Most significant conduit-related complications occur within 90days after surgery.
Division of Gynecologic Surgery, Mayo Clinic, 200 1st St. SW, Rochester, MN 55905, USA.
Zaid M
ZM
Tabbaa
Division of Gynecologic Surgery, Mayo Clinic, 200 1st St. SW, Rochester, MN 55905, USA.
Jo Marie T
JM
Janco
Division of Gynecologic Surgery, Mayo Clinic, 200 1st St. SW, Rochester, MN 55905, USA.
Andrea
A
Mariani
Division of Gynecologic Surgery, Mayo Clinic, 200 1st St. SW, Rochester, MN 55905, USA.
Sean C
SC
Dowdy
Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Michaela E
ME
McGree
Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Amy L
AL
Weaver
Division of Gynecologic Surgery, Mayo Clinic, 200 1st St. SW, Rochester, MN 55905, USA. Electronic address: cliby.william@mayo.edu.
William A
WA
Cliby
D000368:Aged; D000714:Anastomosis, Surgical / Q000379:methods; D057868:Anastomotic Leak; D012809:Colon, Sigmoid / Q000637:transplantation*; D044684:Colon, Transverse / Q000637:transplantation*; D005260:Female; D005833:Genital Neoplasms, Female / Q000601:surgery*; D006801:Humans; D007082:Ileum / Q000637:transplantation*; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D010385:Pelvic Exenteration / Q000379:methods*; D011183:Postoperative Complications; D012189:Retrospective Studies; D014517:Ureteral Obstruction; D014547:Urinary Diversion / Q000379:methods*
Gynecologic malignancy; Incontinent; Outcomes; Urinary conduit