Meta analysis of the association of rs7702187 SNP in SEMA5A gene with risk of Parkinson's disease.
OBJECTIVE
The aim of our study was to derive a more precise estimation of the association between the SEMA5A rs7702187 polymorphism and the susceptibility for PD by using meta-analysis.


METHODS
We searched and collected articles in English or Chinese from the databases of Medline, PubMed, Embase, and Web of Science (updated to September 31, 2010) by using the search terms "semaphorin gene", "Parkinson's disease", "SNPs" and "polymorphism".


RESULTS
All of these selected studies should meet all of the inclusion criterias such as "case-control studies", "similar study method", "sufficient published data for estimating an odds ratio (OR) with 95% confidence interval (CI)". As a result, 12 studies in different populations including 3539 cases and 3250 controls were selected.


CONCLUSIONS
Our meta-analysis suggests that the Single-Nucleotide Polymorphism (SNP) of rs7702187 within the SEMA5A gene would be a high-penetrant risk factor for PD development in western population (p = 0.20 for heterogeneity, OR = 0.87, 95% CI = [0.79, 0.96]).
X
X
Yu
F
F
Wang
J-P
JP
Zhang
D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016017:Odds Ratio; D010300:Parkinson Disease / Q000209:etiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012306:Risk; D012307:Risk Factors; D039961:Semaphorins; D044465:White People / Q000235:genetics
D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C491228:SEMA5A protein, human; D039961:Semaphorins