Relationship of serum bisphenol A with diabetes in the Thai population, National Health Examination Survey IV, 2009.
BACKGROUND
Epidemiological studies of the association between bisphenol A (BPA) exposure and diabetes have been inconsistent. The present study determined serum BPA concentrations in the Thai population and their association with hyperglycemia and diabetes.


METHODS
In all, 2581 serum samples from the Thai National Health Examination Survey (2009) were used to determine BPA levels. Impaired fasting glucose (IFG) was defined as fasting plasma glucose ≥100 and <126 mg/dL. Diabetes was defined as a history of a physician's diagnosis or fasting plasma glucose ≥126 mg/dL. Multinomial logistic regression was used to examine the association of serum BPA with IFG and diabetes.


RESULTS
Of 2581 samples tested, BPA was detected in 2135 samples (weighted percentage 78.1%), with a geometric mean concentration of 0.34 ng/mL BPA. Serum BPA levels were significantly higher among those with diabetes or IFG compared with normoglycemic individuals (0.52 and 0.38 vs 0.33 ng/mL, respectively; P < 0.001). After adjusting for potential confounders, compared with the first quartile (≤0.071 ng/mL), the overall adjusted odds ratios (OR) of serum BPA concentration in the third and fourth quartiles (0.319-0.745 and ≥0.746 ng/mL, respectively) for IFG were 1.72 (95% confidence interval [CI] 1.19, 2.49) and 1.23 (95% CI 0.80, 1.89), respectively; for diabetes, the adjusted OR were 1.88 (95% CI 1.18, 2.99) and 1.83 (95% CI 1.12, 2.95), respectively, with a slightly stronger association among men than in women.


CONCLUSIONS
Serum BPA concentrations were not associated with IFG, but were positively associated with diabetes in the Thai population. Further prospective studies are needed to confirm the relationship.
Department of Community Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Wichai
W
Aekplakorn
La-Or
LO
Chailurkit
Boonsong
B
Ongphiphadhanakul
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001559:Benzhydryl Compounds / Q000097:blood* / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis*; D002681:China; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D016166:Free Radical Scavengers / Q000097:blood* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D010636:Phenols / Q000097:blood* / Q000627:therapeutic use; D011379:Prognosis; D013785:Thailand; D055815:Young Adult; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D001786:Blood Glucose; D016166:Free Radical Scavengers; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
bisphenol A; diabetes; endocrine disruptor; impaired fasting glucose; 关键词：双酚丙烷，糖尿病，内分泌干扰物，空腹葡萄糖受损