Positional oximetry to screen for pulmonary arteriovenous malformations in HHT.
Orthodeoxia has been described in patients with hereditary haemorrhagic telangiectasia (HHT) and pulmonary arteriovenous malformations (PAVM), but its usefulness in screening children for PAVMs is unknown. We show here that while oximetry is overall lower in children with significant PAVMs, supine and upright oximetry is of no additional diagnostic value indicating that positional oximetry is not a useful screening test for PAVMs.
Division of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada.
Susan
S
Carpenter
Division of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada.
Janina
J
Josepovici
Division of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada.
Giuseppe
G
Latino
Division of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada Physiology & Experimental Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada University of Toronto, Toronto, Canada.
Felix
F
Ratjen
D001165:Arteriovenous Malformations / Q000175:diagnosis*; D002648:Child; D006801:Humans; D010092:Oximetry / Q000379:methods*; D011651:Pulmonary Artery / Q000002:abnormalities*; D011667:Pulmonary Veins / Q000002:abnormalities*; D015203:Reproducibility of Results
Rare lung diseases