Exercise-induced cardiac fatigue in low and normal birth weight young black adults.
The objective of the study was to compare the change in diastolic function, E/A ratio, in response to prolonged exercise in low birth weight and normal birth weight individuals. Using a case-control study design, 23 students of the University of Zimbabwe College of Health Sciences who had neonatal clinic cards as proof of birth weight were recruited into the study. Measurements of diastolic function, E/A ratio, were obtained using an echocardiogram before and after 75 minutes of exercise. Among the cohort, seven had low birth weight - <2500 g, three female patients and four male patients - and 16 had normal birth weight - six female patients and 10 male patients). The mean age was 20.7±3.3 years. After prolonged exercise for 75 minutes of running on a treadmill, decreases in diastolic function, E/A ratio, were significantly greater in low birth weight than in normal birth weight individuals (0.48±0.27 versus 0.19±0.18 p<0.05, respectively). There was a significant association between low birth weight and exercise-induced cardiac fatigue (the χ2 test p<0.05, odds ratio 4.64, 95% confidence interval 1.19-18.1). We conclude that low birth weight is associated with exercise-induced diastolic dysfunction in young adults.
1Department of Physiology,University of Zimbabwe,College of Health Sciences,Mount Pleasant,Harare,Zimbabwe.
Jephat
J
Chifamba
1Department of Physiology,University of Zimbabwe,College of Health Sciences,Mount Pleasant,Harare,Zimbabwe.
Chidochashe
C
Mapfumo
2Department of Radiology,Parirenyatwa Group of Hospitals,Avondale,Harare,Zimbabwe.
Dorcas W
DW
Mawoneke
1Department of Physiology,University of Zimbabwe,College of Health Sciences,Mount Pleasant,Harare,Zimbabwe.
Lenon T
LT
Gwaunza
3Section of Advanced Heart Failure and Transplant,University of Colorado School of Medicine,Aurora,United States of America.
Larry A
LA
Allen
1Department of Physiology,University of Zimbabwe,College of Health Sciences,Mount Pleasant,Harare,Zimbabwe.
Herbert M
HM
Chinyanga
D000293:Adolescent; D001741:Black or African American / Q000208:ethnology; D001724:Birth Weight / Q000502:physiology*; D016022:Case-Control Studies; D003971:Diastole / Q000502:physiology; D004452:Echocardiography; D005080:Exercise Test / Q000379:methods; D005221:Fatigue / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D007230:Infant, Low Birth Weight / Q000502:physiology*; D008297:Male; D012420:Running / Q000502:physiology*; D013334:Students; D016277:Ventricular Function, Left / Q000502:physiology; D055815:Young Adult
diastolic function