Chemokines Responses to Ascaris Lumbricoides Sole Infection and Co-infection with Hookworm among Nigerians.
BACKGROUND
Geohelminth infections are predominant in Nigeria and communities at greatest risks are those with poor environmental/sanitary conditions and unhygienic habits. Chemokine ligands (CXCL) a class under chemokine group play important roles in the immune system by either mediating susceptible or protective immune responses to parasitic infections.


OBJECTIVE
This study was to assess the impact of Ascaris lumbricoides sole infection and co-infection on some serum chemokines (CXCL5, CXCL9, and CXCL11) in infected Nigerians.


METHODS
A total of 194 individuals attending Agbor general hospital were examined for A. lumbricoides and hookworm infections. Thereafter, sera were obtained from positive volunteers and control group using enzyme-linked immunosorbent assay to examine the impact of these helminth infections on the serum concentration of some chemokines (CXCL5, CXCL9, and CXCL11).


RESULTS
The mean sera levels of CXCL5 and CXCL9 in infected volunteers were higher than the control subjects. Also, positive correlation was recorded for CXCL9 (P > 0.05), while negative responses were seen for CXCL5 and CXCL11 (P > 0.05) in relation to increase in the intensities of infections. CXCL9 was more expressed in A. lumbricoides + hookworm co-infections than single. Furthermore, the mean concentration of CXCL5 was higher in infected females than males (P < 0.05).


CONCLUSIONS
The proinflammatory responses of CXCL5 and CXCL9 to A. lumbricoides and hookworm infections could be an indication of the meditating roles of these chemokines in the immune system to either confer some form of host/parasite immunity or susceptibility.
Department of Industrial Safety and Environmental Technology, Petroleum Training Institute, Warri, Delta State, Ekpoma, Nigeria ; Tropical Disease Research Unit, Department of Zoology, Ekpoma, Nigeria.
Omorodion Oriri
OO
Asemota
Tropical Disease Research Unit, Department of Zoology, Ekpoma, Nigeria.
O P G
OP
Nmorsi
Tropical Disease Research Unit, Department of Zoology, Ekpoma, Nigeria.
C
C
Isaac
Tropical Disease Research Unit, Department of Zoology, Ekpoma, Nigeria.
E M
EM
Odoya
Tropical Disease Research Unit, Department of Zoology, Ekpoma, Nigeria.
J
J
Akinseye
Department of Microbiology, Ambrose Alli University, Ekpoma, Nigeria.
O
O
Isaac
A. lumbricoides; Chemokines; Co-infection; Hookworm; Nigeria; Single infection