Evaluating effects of deferoxamine in a rat tibia critical bone defect model.
OBJECTIVE
Evaluate the use of deferoxamine in a calcium sulfate carrier to promote fracture healing in a critical bone defect model.


METHODS
43 female retired breeders were divided randomly into Control, Carrier, DFO and BMP groups and appropriate agents placed at the osteotomy site.


RESULTS
There was a significant difference in the mean gap between groups Control vs DFO and Control vs BMP. A higher mean number of cortices were bridged in the DFO group as compared to the Control group.


CONCLUSIONS
Our study demonstrated that DFO helped reduce the gap in this critical tibia defect.
Department of Orthopaedics, University of North Carolina Hospitals, NC 27514, USA.
Bikramjit S
BS
Grewal
Joint Department of Biomedical Engineering, University of North Carolina, NC 27599, USA.
Benjamin
B
Keller
Department of Orthopaedics, University of North Carolina Hospitals, NC 27514, USA ; Joint Department of Biomedical Engineering, University of North Carolina, NC 27599, USA.
Paul
P
Weinhold
Department of Orthopaedics, University of North Carolina Hospitals, NC 27514, USA.
Laurence E
LE
Dahners
Angiogenesis; Critical bone defect; Deferoxamine