Prolonged (9 h) poikilocapnic hypoxia (12% O2) augments cutaneous thermal hyperaemia in healthy humans.
The primary aim of this study was to investigate the effect of systemic poikilocapnic hypoxia on forearm cutaneous thermal hyperaemia. A secondary aim was to examine the relationship between the individual susceptibility to oxygen desaturation and cutaneous vasodilator capacity. Twelve healthy participants (seven male) were exposed to 9 h of normoxia and 12% poikilocapnic hypoxia in a temperature- and humidity-controlled environmental chamber. Skin blood flow was assessed at the ventral forearm using laser Doppler flowmetry combined with rapid local heating. After 6 min at baseline (skin temperature clamped at 33°C), local skin temperature was elevated at a rate of 0.5°C every 5 s up to 42°C to elicit a sensory axon response and then held constant for 30 min to cause a plateau. Skin blood flow was calculated as cutaneous vascular conductance [CVC; in perfusion units/mean arterial blood pressure (APU mmHg(-1))] and expressed in raw format and relative to heating at 44°C in normoxia (%CVC44). During hypoxaemia, vasodilatation was greater during the initial peak (raw, Δ0.35 APU mmHg(-1), P = 0.09; %CVC44, Δ18%, P = 0.05) and the plateau phase (raw, Δ0.55 APU mmHg(-1), P = 0.03; %CVC44, Δ26%, P = 0.02). The rate of rise in cutaneous blood flow during the initial peak was significantly greater during poikilocapnic hypoxia (P < 0.01). We observed a negative relationship between oxygen saturation in poikilocapnic hypoxia and the change in baseline (P = 0.06), initial peak (P = 0.01) and plateau phase of thermal hyperaemia (P = 0.01). Prolonged poikilocapnic hypoxia causes robust increases in CVC during both phases of thermal hyperaemia that are dependent on the oxygen saturation of the individual.
Extremes Research Group, School of Sport, Health and Exercise Sciences, Bangor University, Gwynedd, UK Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX, USA justinlawley@texashealth.org.
Justin S
JS
Lawley
Extremes Research Group, School of Sport, Health and Exercise Sciences, Bangor University, Gwynedd, UK.
Samuel J
SJ
Oliver
Bangor Imaging Center, School of Psychology, Bangor University, Gwynedd, UK.
Paul G
PG
Mullins
Extremes Research Group, School of Sport, Health and Exercise Sciences, Bangor University, Gwynedd, UK.
Jamie H
JH
Macdonald
Extremes Research Group, School of Sport, Health and Exercise Sciences, Bangor University, Gwynedd, UK.
Jonathan P
JP
Moore
D000328:Adult; D001273:Atmosphere Exposure Chambers; D005260:Female; D006358:Hot Temperature; D006801:Humans; D006940:Hyperemia / Q000378:metabolism* / Q000503:physiopathology; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D016037:Single-Blind Method; D012867:Skin / Q000098:blood supply* / Q000378:metabolism*; D013997:Time Factors; D014664:Vasodilation / Q000502:physiology; D055815:Young Adult