XPF-673C>T polymorphism effect on the susceptibility to esophageal cancer in Chinese population.
OBJECTIVE
Xeroderma pigmentsum group F (XPF) plays a pivotal role in DNA nucleotide excision repair and has been linked to the development of various cancers. This study aims to assess the association of XPF genetic variants with the susceptibility to esophageal squamous cell carcinoma (ESCC) in Chinese population.


METHODS
This two-stage case-control study was conducted in a total of 1524 patients with ESCC and 1524 controls. Genotype of XPF -673C>T and 11985A>G variants were determined by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Logistic regression analysis was performed to estimate odd ratios (ORs) and 95% confidence intervals (95% CI).


RESULTS
Our case-control study showed that XPF -673TT genotype was associated with a decreased risk of ESCC compared with CC genotype in both case-control sets (Tangshan set: OR = 0.58; 95%CI = 0.34-0.99, P = 0.040; Beijing set: OR = 0.66; 95%CI = 0.46-0.95, P = 0.027). Stratified analyses revealed that a multiplicative interaction between -673C>T variant and age, sex or smoking status was evident (Gene-age: Pinteraction = 0.002; Gene-sex: Pinteraction = 0.002; Gene-smoking: Pinteraction = 0.002). For XPF 11985A>G polymorphism, there was no significant difference of genotype distribution between ESCC cases and controls.


CONCLUSIONS
These findings indicated that genetic variants in XPF might contribute to the susceptibility to ESCC.
Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan, China; Department of Epidemiology, College of Public Health, Hebei United University, Tangshan, China.
Yingwen
Y
Liu
Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan, China.
Lei
L
Cao
Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Jiang
J
Chang
Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan, China.
Jia
J
Lin
Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan, China.
Bing
B
He
Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan, China.
Juan
J
Rao
Hebei United University Affiliated Tangshan Gongren Hospital, Tangshan, China.
Zhi
Z
Zhang
Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan, China.
Xuemei
X
Zhang
D000368:Aged; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D004268:DNA-Binding Proteins; C095888:xeroderma pigmentosum group F protein