Strippers reveal their depressing secrets: removing AMPA receptors.
How do microglia regulate synaptic function? In this issue of Neuron, Zhang et al. (2014) describe a novel form of long-term depression of AMPA receptor-mediated synaptic transmission in the hippocampus involving the activation of microglia.
Centre for Synaptic Plasticity, University of Bristol, Bristol BS1 3NY, UK. Electronic address: glcollingridge@gmail.com.
Graham L
GL
Collingridge
Centre for Synaptic Plasticity, University of Bristol, Bristol BS1 3NY, UK; Inserm U1141/Université Paris Diderot Sorbonne Paris Cité/PremUP, Hôpital Robert Debré, 75019 Paris, France.
Stephane
S
Peineau
D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D016177:Macrophage-1 Antigen / Q000378:metabolism*; D017628:Microglia / Q000378:metabolism*; D019255:NADPH Oxidases / Q000378:metabolism*
D016177:Macrophage-1 Antigen; D019255:NADPH Oxidases