Pharmacologic prevention of perinatal HIV infection.
The goal of antiretroviral therapy for the prevention of mother-to-child transmission (PMTCT) of HIV is to achieve maximal suppression of maternal viral load with minimal maternal, fetal and infant toxicity during pregnancy, delivery and postpartum. In addition to the efficacy and toxicity of antiretroviral therapy, the consideration of HIV resistance in mothers and infected newborns further complicates therapeutic choices for PMTCT. This manuscript summarizes current approaches to PMTC in diverse international settings.
Division of Infectious Disease, Washington, DC, USA; Division of Pediatric Clinical Pharmacology, Children's National Health System, Washington, DC, USA; Elisabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA; Department of Pediatrics, the George Washington University School of Medicine and Health Sciences, Washington, DC, USA. Electronic address: nrakhman@childrensnational.org.
Natella Y
NY
Rakhmanina
Division of Pediatric Clinical Pharmacology, Children's National Health System, Washington, DC, USA; Department of Pediatrics, the George Washington University School of Medicine and Health Sciences, Washington, DC, USA; Department of Pharmacology and Physiology, the George Washington University School of Medicine and Health Sciences, Washington, DC, USA; Intensive Care, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Paediatric Pharmacology, University Children's Hospital Basel, Switzerland.
Johannes N
JN
van den Anker
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D005260:Female; D015658:HIV Infections / Q000151:congenital / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000517:prevention & control
D019380:Anti-HIV Agents
HIV; Perinatal; Prophylaxis; amntiretroviral