Oxacycle synthesis via intramolecular reaction of carbanions and peroxides.
The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonation, provides a new approach to cyclic ethers. Applied in tandem with C-C bond formation, the strategy enables a one-step annelation to form oxaospirocycles.
Department of Chemistry, University of Nebraska-Lincoln , Lincoln, Nebraska 68588-0304, United States.
Rachel
R
Willand-Charnley
Benjamin W
BW
Puffer
Patrick H
PH
Dussault
D060326:Chemistry Techniques, Synthetic; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D010545:Peroxides / Q000737:chemistry*; D013379:Substrate Specificity
D004988:Ethers, Cyclic; D010545:Peroxides