The combination of CO2 laser vaporation and photodynamic therapy in treatment of condylomata acuminata.
The aim of this study was to investigate the effectiveness of CO2 laser vaporation and topical PDT combination on condylomata acuminate (CA) located in the perianal and external genital area. A total of 119 patients (perianal CA=52 cases and external genital CA=67 cases) with at least one CA lesion >2mm were treated with monopulse CO2 laser followed by topical ALA-PDT. PDT was repeated till complete response was achieved. Approximately half of the patients only needed one session of PDT treatment and another half needed multiple PDT treatments to achieve complete response. During the 6-month follow-up 7.1% of patients relapsed. In terms of complete response rate and recurrence rate there were no statistical differences between perianal and genital groups. No severe adverse effects were observed. CO2 laser vaporation plus ALA-PDT is a highly effective modality for treating CA.
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Jinhua
J
Huang
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Qinghai
Q
Zeng
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Chengxin
C
Zuo
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Shengbo
S
Yang
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Yaping
Y
Xiang
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Jianyun
J
Lu
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Jian
J
Kang
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Lina
L
Tan
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Xiaoli
X
Yu
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Caiyun
C
Xi
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Jian
J
Huang
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China.
Liyang
L
Kang
Xiangya Hospital, Central South University, Changsha 410008, PR China.
Fan
F
Fan
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, PR China. Electronic address: 43700351@qq.com.
Jing
J
Chen
D000328:Adult; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000473:pathology* / Q000628:therapy*; D062109:Dermatologic Surgical Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D016896:Treatment Outcome
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid
CO(2) laser; Condylomata acuminate; External genitals; Perianal; Photodynamic therapy