Consanguinity pattern and heritability of Vitiligo in Arar, Saudi Arabia.
BACKGROUND
Epidemiological studies have shown that vitiligo is a complex trait, involving combinations of pathogenic effects of multiple susceptibility genes as well as environmental risk factors.


OBJECTIVE
To observe whether consanguinity increased the incidence of vitiligo in Saudi patients from Arar.


METHODS
This study included 69 Saudi patients with vitiligo and their families. These patients, selected from the experience specialist dermatology center in Arar, from April 2011 to 2012, were interviewed by a dermatologist to confirm the diagnosis and complete a questionnaire.


RESULTS
A total of 69 patients, 40 males and 29 females were selected. Their mean age was 34.5 ± 11.8 years with the median age of 23 years. The mean age at onset of disease was 27.9 ± 12.9 years. The mean duration of the disease was 9.7 ± 5.3 years. The frequency of focal, vulgaris, universal, and acrofacial subtypes was 22 (31.9%), 21 (30.4%), 8 (11.6%), and 18 (26.1%), respectively. A positive family history of vitiligo was obtained in 45 (65.2%) cases. A comparison of the frequency of vitiligo among siblings in relation to the general population was more in accord with the multifactorial model.


CONCLUSIONS
Consanguinity in marriage increases the incidence of the disease. Therefore, genetic counseling and premarital examination would be important contributions to lower the prevalence of vitiligo.
Department of Dermatology, College of Medicine, Northern Borders University, Arar, Kingdom of Saudi Arabia.
Dhaifallah A
DA
Alenizi
Arar; consanguinity pattern; genetic; vitiligo