Genome-wide screening and identification of long noncoding RNAs and their interaction with protein coding RNAs in bladder urothelial cell carcinoma.
To understand lncRNAs expression profiling and their potential functions in bladder cancer, we investigated the lncRNA and coding RNA expression on human bladder cancer and normal bladder tissues. Bioinformatic analysis revealed thousands of significantly differentially expressed lncRNAs and coding mRNA in bladder cancer relative to normal bladder tissue. Co-expression analysis revealed that 50% of lncRNAs and coding RNAs expressed in the same direction. A subset of lncRNAs might be involved in mTOR signaling, p53 signaling, cancer pathways. Our study provides a large scale of co-expression between lncRNA and coding RNAs in bladder cancer cells and lays biological basis for further investigation.
Department of Urology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China.
Longxin
L
Wang
Department of Urology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China.
Dian
D
Fu
Rehabilitation Center, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China.
Yongbin
Y
Qiu
Department of Urology, Maternal and Children Health Hospital of Nantong City, Nantong City, Jiangsu Province, People's Republic of China.
Xiaoxiao
X
Xing
Department of Urology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China.
Feng
F
Xu
Department of Urology, The Affiliated School of Clinical Medicine of Xuzhou Medical College, Xuzhou Central Hospital, Xuzhou, Jiangsu Province, People's Republic of China.
Conghui
C
Han
Department of Urology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China.
Xiaofeng
X
Xu
Department of Urology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China.
Zhifeng
Z
Wei
Department of Urology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China.
Zhengyu
Z
Zhang
Department of Urology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China.
Jingping
J
Ge
Department of Urology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China. Electronic address: Dr_chengwen@126.com.
Wen
W
Cheng
Institute of Cancer Research, School of Medicine, University of South China, Hengyang, Hunan Province, People's Republic of China. Electronic address: xhl0078@sina.com.cn.
Hai-Long
HL
Xie
D002295:Carcinoma, Transitional Cell / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D059467:Transcriptome; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D001743:Urinary Bladder / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000378:metabolism
D062085:RNA, Long Noncoding; D012333:RNA, Messenger; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases
Co-expression; Long noncoding RNA; Urothelial carcinoma of bladder; lncRNA