Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients.
Immunocompromised patients may develop severe chronic anaemia when infected by human parvovirus B19 (B19V). However, this is not the case in human immunodeficiency virus (HIV)-infected patients with good adherence to highly active antiretroviral treatment (HAART). In this study, we investigated the clinical evolution of five HIV-infected patients receiving HAART who had B19V infections confirmed by serum polymerase chain reaction. Four of the patients were infected with genotype 1a strains and the remaining patient was infected with a genotype 3b strain. Anaemia was detected in three of the patients, but all patients recovered without requiring immunoglobulin and/or blood transfusions. In all cases, the attending physicians did not suspect the B19V infections. There was no apparent relationship between the infecting genotype and the clinical course. In the HAART era, B19V infections in HIV-positive patients may be limited, subtle or unapparent.
Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brasil.
Renata Freire Alves
RF
Pereira
Departamento de Microbiologia e Parasitologia, Instituto Biomédico, Universidade Federal Fluminense, Niterói, RJ, Brasil.
Rita de Cássia Nasser Cubel
Rde C
Garcia
Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brasil.
Kátia Martins Lopes de
KM
Azevedo
Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brasil.
Sérgio
S
Setúbal
Laboratório de Vírus Respiratórios e Sarampo, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil.
Marilda Agudo Mendonça Teixeira de
MA
Siqueira
Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brasil.
Solange Artimos de
SA
Oliveira
D000328:Adult; D000740:Anemia / Q000150:complications / Q000175:diagnosis; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D023241:Antiretroviral Therapy, Highly Active; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000150:complications / Q000276:immunology*; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction
D000914:Antibodies, Viral; D015415:Biomarkers