Combined volatolomics for monitoring of human body chemistry.
Analysis of volatile organic compounds (VOCs) is a promising approach for non-invasive, fast and potentially inexpensive diagnostics. Here, we present a new methodology for profiling the body chemistry by using the volatile fraction of molecules in various body fluids. Using mass spectrometry and cross-reactive nanomaterial-based sensors array, we demonstrate that simultaneous VOC detection from breath and skin would provide complementary, non-correlated information of the body's volatile metabolites profile. Eventually with further wide population validation studies, such a methodology could provide more accurate monitoring of pathological changes compared to the information provided by a single body fluid. The qualitative and quantitative methods presented here offers a variety of options for novel mapping of the metabolic properties of complex organisms, including humans.
The Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa 3200003, Israel.
Yoav Y
YY
Broza
The Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa 3200003, Israel.
Liat
L
Zuri
The Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa 3200003, Israel.
Hossam
H
Haick
D000328:Adult; D001669:Biochemical Phenomena; D001944:Breath Tests; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D018594:Human Body; D006801:Humans; D008297:Male; D055432:Metabolomics; D025341:Principal Component Analysis; D012867:Skin / Q000737:chemistry*; D055549:Volatile Organic Compounds / Q000032:analysis*
D055549:Volatile Organic Compounds