Anthocyanins: targeting of signaling networks in cancer cells.
It is becoming progressively more understandable that phytochemicals derived from edible plants have shown potential in modelling their interactions with their target proteins. Rapidly accumulating in-vitro and in- vivo evidence indicates that anthocyanins have anticancer activity in rodent models of cancer. More intriguingly, evaluation of bilberry anthocyanins as chemopreventive agents in twenty-five colorectal cancer patients has opened new window of opportunity in translating the findings from laboratory to clinic. Confluence of information suggests that anthocyanins treated cancer cells reveal up-regulation of tumor suppressor genes. There is a successive increase in the research-work in nutrigenomics and evidence has started to shed light on intracellular-signaling cascades as common molecular targets for anthocyanins. In this review we bring to limelight how anthocyanins induced apoptosis in cancer cells via activation of extrinsic and intrinsic pathways.
Department of Medical Biochemistry, Canakkale Onsekiz Mart University, Canakkale, Turkey E-mail : hilals@comu.edu.tr ammadahmad638@yahoo.com.
Muserref Hilal
MH
Sehitoglu
Ammad Ahmad
AA
Farooqi
Muhammad Zahid
MZ
Qureshi
Ghazala
G
Butt
Aliye
A
Aras
D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology* / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D015398:Signal Transduction / Q000187:drug effects*
D000872:Anthocyanins; D000970:Antineoplastic Agents