Placental expression of PHLDA2 in selective intrauterine growth restriction in monozygotic twins.
Studies have showed that increase of placental expression of imprinted genes PHLDA2 may have a potential regulatory role in fetal IUGR (intrauterine growth restriction) in singleton. In this study, we investigate the expression level of PHLDA2 in placenta of monozygotic twins (MZT) with selective intrauterine growth restriction (sIUGR) and normal MZT. Both mRNA levels and protein levels of PHLDA2 were signiﬁcantly increased in placenta sharings of small fetus in cases of sIUGR. Our results suggest upregulated PHLDA2 in placenta may be associated with the pathogenesis of sIUGR.
Fatal Medicine Center, The First Afﬁliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
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X
Shi
Fatal Medicine Center, The First Afﬁliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
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Z
He
Fatal Medicine Center, The First Afﬁliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
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Y
Gao
Fatal Medicine Center, The First Afﬁliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
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Luo
Fatal Medicine Center, The First Afﬁliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
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Gou
Fatal Medicine Center, The First Afﬁliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. Electronic address: fang_qun@163.com.
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Fang
D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics*; D015870:Gene Expression; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D009687:Nuclear Proteins / Q000032:analysis / Q000235:genetics*; D010920:Placenta / Q000737:chemistry / Q000378:metabolism*; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014430:Twins, Monozygotic / Q000235:genetics*
D009687:Nuclear Proteins; D012333:RNA, Messenger; C109277:TSSC3 protein
Monozygotic twin; PHLDA2; Placenta; sIUGR