Salivary testosterone and immunoglobulin A were increased by resistance training in adults with Down syndrome.
This study was designed to assess the influence of resistance training on salivary immunoglobulin A (IgA) levels and hormone profile in sedentary adults with Down syndrome (DS). A total of 40 male adults with DS were recruited for the trial through different community support groups for people with intellectual disabilities. All participants had medical approval for participation in physical activity. Twenty-four adults were randomly assigned to perform resistance training in a circuit with six stations, 3 days per week for 12 weeks. Training intensity was based on functioning in the eight-repetition maximum (8RM) test for each exercise. The control group included 16 age-, gender-, and BMI-matched adults with DS. Salivary IgA, testosterone, and cortisol levels were measured by ELISA. Work task performance was assessed using the repetitive weighted-box-stacking test. Resistance training significantly increased salivary IgA concentration (P=0.0120; d=0.94) and testosterone levels (P=0.0088; d=1.57) in the exercising group. Furthermore, it also improved work task performance. No changes were seen in the controls who had not exercised. In conclusion, a short-term resistance training protocol improved mucosal immunity response as well as salivary testosterone levels in sedentary adults with DS.
School of Medicine, University of Cadiz, Cadiz, Spain.
G
G
Fornieles
School of Sports Sciences, University of Cadiz, Cadiz, Spain.
M A
MA
Rosety
School of Medicine, University of Cadiz, Cadiz, Spain.
S
S
Elosegui
Division of Urology, University Hospital Puerta del Mar Cadiz, Cadiz, Spain.
J M
JM
Rosety
School of Sports Medicine, University of Cadiz, Cadiz, Spain.
J R
JR
Alvero-Cruz
School of Medicine, University of Cadiz, Cadiz, Spain.
N
N
Garcia
School of Sports Medicine, University of Malaga, Malaga, Spain.
M
M
Rosety
Division of Gynecology, University Hospital Jerez, Cadiz, Spain.
T
T
Rodriguez-Pareja
School of Medicine, University of Cadiz, Cadiz, Spain.
R
R
Toro
School of Medicine, University of Cadiz, Cadiz, Spain.
M
M
Rosety-Rodriguez
School of Sports Medicine, University of Malaga, Malaga, Spain.
F J
FJ
Ordonez
School of Medicine, University of Cadiz, Cadiz, Spain.
I
I
Rosety
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D065327:Circuit-Based Exercise; D004314:Down Syndrome / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D008297:Male; D055070:Resistance Training; D012463:Saliva / Q000737:chemistry*; D057185:Sedentary Behavior; D013195:Stanford-Binet Test; D013647:Task Performance and Analysis; D013739:Testosterone / Q000378:metabolism*
D007071:Immunoglobulin A, Secretory; D013739:Testosterone; D006854:Hydrocortisone