Oral Administration of MBG to Modulate Immune Responses and Suppress OVA-Sensitized Allergy in a Murine Model.
Recently studies performed on mushroom isolated polysaccharides demonstrated that β -(1,3)-glucan may affect the balance of Th1/Th2 cell response. Using ovalbumin (OVA) as a hypersensitivity inducer, we evaluated the ability of mushroom beta-glucan (MBG) in modulating Th1/Th2 cell responses in B6 mice. As compared to the control group, administration of MBG resulted in an increase of phagocytic activities, Th1 cytokine productions, immunoglobulins including IgG2A and IgA, and a significant expression of the splenic surface markers including CD3, CD4, CD8, and F4/80. In contrast, administration of MBG has significantly suppressed IgE and IgG1 levels and Th2 cytokines including IL-4, IL-5, and IL-6. Histopathological observation of MBG-treated followed by OVA-treated mice showed less filtration of eosinophil in pulmonary tissue sections. Our data suggested that administration of MBG treatments alters the natural course of the IgE-mediated hypersensitivities. In this investigation, we realize the mushroom beta glucan alter the Th2 response toward the Th1 in the allergic, resulting in a reduction in IgE productions which played a substantive role in reducing the severity of IgE-mediated hypersensitivity.
College of Life Sciences, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Da'an District, Taipei City 10617, Taiwan.
Yu-Sheng
YS
Wu
Department of Research and Development, Super Beta Glucan Inc., Irvine, CA, USA.
Sherwin
S
Chen
Department of Research and Development, Super Beta Glucan Inc., Irvine, CA, USA.
William
W
Wang
College of Life Sciences, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Da'an District, Taipei City 10617, Taiwan.
Chung-Lun
CL
Lu
Graduate Institute of Integration of Traditional Chinese Medicine with Western Nursing, National Taipei University of Nursing and Health Sciences, Taipei 11031, Taiwan.
Chi-Feng
CF
Liu
College of Life Sciences, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Da'an District, Taipei City 10617, Taiwan.
Shiu-Nan
SN
Chen