Effect of intra-abdominal pressure on respiratory function in patients undergoing ventral hernia repair.
OBJECTIVE
To determine the influence of intra-abdominal pressure (IAP) on respiratory function after surgical repair of ventral hernia and to compare two different methods of IAP measurement during the perioperative period.


METHODS
Thirty adult patients after elective repair of ventral hernia were enrolled into this prospective study. IAP monitoring was performed via both a balloon-tipped nasogastric probe [intragastric pressure (IGP), CiMON, Pulsion Medical Systems, Munich, Germany] and a urinary catheter [intrabladder pressure (IBP), UnoMeterAbdo-Pressure Kit, UnoMedical, Denmark] on five consecutive stages: (1) after tracheal intubation (AI); (2) after ventral hernia repair; (3) at the end of surgery; (4) during spontaneous breathing trial through the endotracheal tube; and (5) at 1 h after tracheal extubation. The patients were in the complete supine position during all study stages.


RESULTS
The IAP (measured via both techniques) increased on average by 12% during surgery compared to AI (P < 0.02) and by 43% during spontaneous breathing through the endotracheal tube (P < 0.01). In parallel, the gradient between РаСО2 and EtCO2 [Р(а-et)CO2] rose significantly, reaching a maximum during the spontaneous breathing trial. The PаO2/FiO2 decreased by 30% one hour after tracheal extubation (P = 0.02). The dynamic compliance of respiratory system reduced intraoperatively by 15%-20% (P < 0.025). At all stages, we observed a significant correlation between IGP and IBP (r = 0.65-0.81, P < 0.01) with a mean bias varying from -0.19 mmHg (2SD 7.25 mmHg) to -1.06 mm Hg (2SD 8.04 mmHg) depending on the study stage. Taking all paired measurements together (n = 133), the median IGP was 8.0 (5.5-11.0) mmHg and the median IBP was 8.8 (5.8-13.1) mmHg. The overall r (2) value (n = 30) was 0.76 (P < 0.0001). Bland and Altman analysis showed an overall bias for the mean values per patient of 0.6 mmHg (2SD 4.2 mmHg) with percentage error of 45.6%. Looking at changes in IAP between the different study stages, we found an excellent concordance coefficient of 94.9% comparing ΔIBP and ΔIGP (n = 117).


CONCLUSIONS
During ventral hernia repair, the IAP rise is accompanied by changes in Р(а-et)CO2 and PаO2/FiO2-ratio. Estimation of IAP via IGP or IBP demonstrated excellent concordance.
Konstantin M Gaidukov, Elena N Raibuzhis, Ayyaz Hussain, Alexey A Smetkin, Vsevolod V Kuzkov, Mikhail Y Kirov, Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, 163001 Arkhangelsk, Russia.
Konstantin M
KM
Gaidukov
Konstantin M Gaidukov, Elena N Raibuzhis, Ayyaz Hussain, Alexey A Smetkin, Vsevolod V Kuzkov, Mikhail Y Kirov, Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, 163001 Arkhangelsk, Russia.
Elena N
EN
Raibuzhis
Konstantin M Gaidukov, Elena N Raibuzhis, Ayyaz Hussain, Alexey A Smetkin, Vsevolod V Kuzkov, Mikhail Y Kirov, Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, 163001 Arkhangelsk, Russia.
Ayyaz
A
Hussain
Konstantin M Gaidukov, Elena N Raibuzhis, Ayyaz Hussain, Alexey A Smetkin, Vsevolod V Kuzkov, Mikhail Y Kirov, Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, 163001 Arkhangelsk, Russia.
Alexey Y
AY
Teterin
Konstantin M Gaidukov, Elena N Raibuzhis, Ayyaz Hussain, Alexey A Smetkin, Vsevolod V Kuzkov, Mikhail Y Kirov, Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, 163001 Arkhangelsk, Russia.
Alexey A
AA
Smetkin
Konstantin M Gaidukov, Elena N Raibuzhis, Ayyaz Hussain, Alexey A Smetkin, Vsevolod V Kuzkov, Mikhail Y Kirov, Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, 163001 Arkhangelsk, Russia.
Vsevolod V
VV
Kuzkov
Konstantin M Gaidukov, Elena N Raibuzhis, Ayyaz Hussain, Alexey A Smetkin, Vsevolod V Kuzkov, Mikhail Y Kirov, Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, 163001 Arkhangelsk, Russia.
Manu Lng
ML
Malbrain
Konstantin M Gaidukov, Elena N Raibuzhis, Ayyaz Hussain, Alexey A Smetkin, Vsevolod V Kuzkov, Mikhail Y Kirov, Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, 163001 Arkhangelsk, Russia.
Mikhail Y
MY
Kirov
Bladder pressure; Gastric pressure; Hernia; Intra-abdominal hypertension; Intra-abdominal pressure; Oxygenation; Respiratory function