DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers.
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose polymerase), and both BRCA1 and BRCA2. In the present study, we have performed a comprehensive analysis of 18 genes involved in BER using a tagging SNP approach in a large series of BRCA1 and BRCA2 mutation carriers. 144 SNPs were analyzed in a two stage study involving 23,463 carriers from the CIMBA consortium (the Consortium of Investigators of Modifiers of BRCA1 and BRCA2). Eleven SNPs showed evidence of association with breast and/or ovarian cancer at p<0.05 in the combined analysis. Four of the five genes for which strongest evidence of association was observed were DNA glycosylases. The strongest evidence was for rs1466785 in the NEIL2 (endonuclease VIII-like 2) gene (HR: 1.09, 95% CI (1.03-1.16), p = 2.7 × 10(-3)) for association with breast cancer risk in BRCA2 mutation carriers, and rs2304277 in the OGG1 (8-guanine DNA glycosylase) gene, with ovarian cancer risk in BRCA1 mutation carriers (HR: 1.12 95%CI: 1.03-1.21, p = 4.8 × 10(-3)). DNA glycosylases involved in the first steps of the BER pathway may be associated with cancer risk in BRCA1/2 mutation carriers and should be more comprehensively studied.
Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
Ana
A
Osorio
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Roger L
RL
Milne
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Karoline
K
Kuchenbaecker
Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.
Tereza
T
Vaclová
Genotyping Unit (CeGen), Spanish National Cancer Centre (CNIO), Madrid, Spain.
Guillermo
G
Pita
Genotyping Unit (CeGen), Spanish National Cancer Centre (CNIO), Madrid, Spain.
Rosario
R
Alonso
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
Paolo
P
Peterlongo
Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
Ignacio
I
Blanco
Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain.
Miguel
M
de la Hoya
Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain.
Mercedes
M
Duran
Oncogenetics Laboratory, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Institut de Recerca (VHIR), and Universitat Autonoma de Barcelona, Barcelona, Spain.
Orland
O
Díez
Oncology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Teresa
T
Ramón Y Cajal
Molecular Diagnostics Laboratory IRRP, National Centre for Scientific Research Demokritos Aghia Paraskevi Attikis, Athens, Greece.
Irene
I
Konstantopoulou
Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain.
Cristina
C
Martínez-Bouzas
Medical Oncology Service, Hospital Clínico Lozano Blesa, San Juan Bosco, Zaragoza, Spain.
Raquel
R
Andrés Conejero
Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Canada.
Penny
P
Soucy
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Lesley
L
McGuffog
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Daniel
D
Barrowdale
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Andrew
A
Lee
Department of Oncology, Lund University, Lund, Sweden.
Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.
Brita
B
Arver
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Johanna
J
Rantala
Department of Oncology, Lund University Hospital, Lund, Sweden.
Niklas
N
Loman
Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.
Hans
H
Ehrencrona
Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, United States of America.
Olufunmilayo I
OI
Olopade
Departments of Medicine, Epidemiology, and Biostatistics, University of California, San Francisco, San Francisco, California, United States of America.
Mary S
MS
Beattie
Abramson Cancer Center and Department of Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.
Susan M
SM
Domchek
Abramson Cancer Center and Department of Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.
Katherine
K
Nathanson
Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Timothy R
TR
Rebbeck
University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Banu K
BK
Arun
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Beth Y
BY
Karlan
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Christine
C
Walsh
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Jenny
J
Lester
Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, United States of America.
Esther M
EM
John
Department of Health Research & Policy, Stanford University School of Medicine, Stanford, California, United States of America.
Alice S
AS
Whittemore
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.
Mary B
MB
Daly
Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia.
Melissa
M
Southey
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Victoria, Australia.
John
J
Hopper
Department of Epidemiology, Columbia University, New York, New York, United States of America.
Mary B
MB
Terry
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
Saundra S
SS
Buys
Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania.
Ramunas
R
Janavicius
Department of Genetics, University of Pretoria, Pretoria, South Africa.
Cecilia M
CM
Dorfling
Department of Genetics, University of Pretoria, Pretoria, South Africa.
Elizabeth J
EJ
van Rensburg
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States of America.
Linda
L
Steele
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States of America.
Susan L
SL
Neuhausen
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States of America.
Yuan Chun
YC
Ding
Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Thomas V O
TV
Hansen
Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Lars
L
Jønson
Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Bent
B
Ejlertsen
Department of Clinical Genetics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Anne-Marie
AM
Gerdes
Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain.
Mar
M
Infante
Genotyping Unit (CeGen), Spanish National Cancer Centre (CNIO), Madrid, Spain.
Belén
B
Herráez
Genotyping Unit (CeGen), Spanish National Cancer Centre (CNIO), Madrid, Spain.
Leticia Thais
LT
Moreno
Clinical Cancer Genetics, City of Hope, Duarte, California, United States of America.
Jeffrey N
JN
Weitzel
Clinical Cancer Genetics, City of Hope, Duarte, California, United States of America.
Josef
J
Herzog
Clinical Cancer Genetics, City of Hope, Duarte, California, United States of America.
Kisa
K
Weeman
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy.
Siranoush
S
Manoukian
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy.
Bernard
B
Peissel
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy.
Daniela
D
Zaffaroni
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy.
Giulietta
G
Scuvera
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy.
Bernardo
B
Bonanni
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
Frederique
F
Mariette
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
Sara
S
Volorio
Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.
Alessandra
A
Viel
Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
Liliana
L
Varesco
Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.
Laura
L
Papi
Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
Laura
L
Ottini
UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, Italy.
Maria Grazia
MG
Tibiletti
Unit of Molecular bases of genetic risk and genetic testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy.
Paolo
P
Radice
Molecular Diagnostics Laboratory IRRP, National Centre for Scientific Research Demokritos Aghia Paraskevi Attikis, Athens, Greece.
Drakoulis
D
Yannoukakos
Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
Judy
J
Garber
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Steve
S
Ellis
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Debra
D
Frost
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Radka
R
Platte
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Elena
E
Fineberg
Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
Gareth
G
Evans
Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
Fiona
F
Lalloo
South East Thames Regional Genetics Service, Guy's Hospital London, United Kingdom.
Louise
L
Izatt
Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom.
Ros
R
Eeles
Yorkshire Regional Genetics Service, Leeds, United Kingdom.
Julian
J
Adlard
Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Glasgow, United Kingdom.
Rosemarie
R
Davidson
West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, United Kingdom.
Trevor
T
Cole
Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom.
Diana
D
Eccles
Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom.
Jackie
J
Cook
Clinical Genetics Department, St Georges Hospital, University of London, London, United Kingdom.
Shirley
S
Hodgson
Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom.
Carole
C
Brewer
Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, United Kingdom.
Marc
M
Tischkowitz
Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.
Fiona
F
Douglas
South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, United Kingdom.
Mary
M
Porteous
North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
Lucy
L
Side
Oxford Regional Genetics Service, Churchill Hospital, Oxford, United Kingdom.
Lisa
L
Walker
Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, United Kingdom.
Patrick
P
Morrison
South West Regional Genetics Service, Bristol, United Kingdom.
Alan
A
Donaldson
Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire.
John
J
Kennedy
Cheshire & Merseyside Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Liverpool, United Kingdom.
Claire
C
Foo
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America.
Andrew K
AK
Godwin
Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
Rita Katharina
RK
Schmutzler
Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
Barbara
B
Wappenschmidt
Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
Kerstin
K
Rhiem
Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Christoph
C
Engel
Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Alfons
A
Meindl
Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Nina
N
Ditsch
Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Norbert
N
Arnold
Institute of Human Genetics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Hans Jörg
HJ
Plendl
Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Dieter
D
Niederacher
Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Christian
C
Sutter
Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
Shan
S
Wang-Gohrke
Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.
Doris
D
Steinemann
Institute of Human Genetics, University of Münster, Münster, Germany.
Sabine
S
Preisler-Adams
Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Karin
K
Kast
Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany.
Raymonda
R
Varon-Mateeva
Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany.
Andrea
A
Gehrig
Institut Curie, Department of Tumour Biology, Paris, France; Institut Curie, INSERM U830, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Dominique
D
Stoppa-Lyonnet
Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon, France; INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Olga M
OM
Sinilnikova
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Sylvie
S
Mazoyer
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Francesca
F
Damiola
Center for Medical Genetics, Ghent University, Ghent, Belgium.
Bruce
B
Poppe
Center for Medical Genetics, Ghent University, Ghent, Belgium.
Kathleen
K
Claes
Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, United States of America.
Marion
M
Piedmonte
Prince of Wales Hospital. Sydney, Australia.
Kathy
K
Tucker
Ohio State University, Columbus Cancer Council, Columbus, Ohio, United States of America.
Floor
F
Backes
Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, Illinois, United States of America.
Gustavo
G
Rodríguez
Division of Gynecologic Oncology, NorthShore University HealthSystem, Chicago, Illinois, United States of America.
Wendy
W
Brewster
For Tufts Medical Center, Boston, Massachusetts, United States of America.
Katie
K
Wakeley
Yale University School of Medicine, New Haven, Connecticut, United States of America.
Thomas
T
Rutherford
Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain.
Trinidad
T
Caldés
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Heli
H
Nevanlinna
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Kristiina
K
Aittomäki
Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Matti A
MA
Rookus
Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands.
Theo A M
TA
van Os
Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Lizet
L
van der Kolk
Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
J L
JL
de Lange
Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands.
Hanne E J
HE
Meijers-Heijboer
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
A H
AH
van der Hout
Department of Clinical Genetics, Leiden University Medical Center Leiden, Leiden, The Netherlands.
Christi J
CJ
van Asperen
Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, MUMC, Maastricht, The Netherlands.
Encarna B
EB
Gómez Garcia
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Nicoline
N
Hoogerbrugge
Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands.
J Margriet
JM
Collée
Department of Pathology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands.
Carolien H M
CH
van Deurzen
Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
Rob B
RB
van der Luijt
Department of Human Genetics & Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Peter
P
Devilee
The Hereditary Breast and Ovarian Cancer Research Group, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
Edith
E
Olah
Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
Conxi
C
Lázaro
Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
Alex
A
Teulé
Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
Mireia
M
Menéndez
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Anna
A
Jakubowska
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Cezary
C
Cybulski
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jacek
J
Gronwald
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jan
J
Lubinski
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Katarzyna
K
Durda
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland; Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland.
Katarzyna
K
Jaworska-Bieniek
Department of Oncology, Landspitali University Hospital and BMC, Faculty of Medicine, University of Iceland, Reykjavik Iceland.
Oskar Th
OT
Johannsson
Laboratoire de Diagnostic Génétique et Service d'Onco-hématologie, Hopitaux Universitaire de Strasbourg, CHRU Nouvel Hôpital Civil, Strasbourg, France.
Christine
C
Maugard
Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Marco
M
Montagna
Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Silvia
S
Tognazzo
Department of Genetics, Portuguese Oncology Institute, Porto, and Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal.
Manuel R
MR
Teixeira
Department of Genetics and Computational Biology, Queensland Institute of Medical Research, Brisbane, Australia.
Sue
S
Healey
Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia.
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
Curtis
C
Olswold
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America.
Lucia
L
Guidugli
Center for Individualized Medicine, Mayo Clinic, Scottsdale, Arizona, United States of America.
Noralane
N
Lindor
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
Susan
S
Slager
Center for Translational Cancer Research, Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America.
Csilla I
CI
Szabo
Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America; Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
Joseph
J
Vijai
Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
Mark
M
Robson
Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
Noah
N
Kauff
Diagnostic Molecular Genetics Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
Liying
L
Zhang
Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
Rohini
R
Rau-Murthy
Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Anneliese
A
Fink-Retter
Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Christian F
CF
Singer
Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Christine
C
Rappaport
Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Daphne
D
Geschwantler Kaulich
Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Georg
G
Pfeiler
Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Muy-Kheng
MK
Tea
Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Andreas
A
Berger
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Catherine M
CM
Phelan
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, United States of America.
Mark H
MH
Greene
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, United States of America.
Phuong L
PL
Mai
Clalit National Israeli Cancer Control Center, Haifa, Israel.
Flavio
F
Lejbkowicz
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, and Cancer Care Ontario, Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Irene
I
Andrulis
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.
Anna Marie
AM
Mulligan
Ontario Cancer Genetics Network: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Gord
G
Glendon
Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.
Amanda Ewart
AE
Toland
Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark.
Anders
A
Bojesen
Section of Molecular Diagnostics, Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
Inge Sokilde
IS
Pedersen
Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
Lone
L
Sunde
Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Mads
M
Thomassen
Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Torben A
TA
Kruse
Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
Uffe Birk
UB
Jensen
Sheba Medical Center, Tel Aviv, Israel.
Eitan
E
Friedman
Sheba Medical Center, Tel Aviv, Israel.
Yael
Y
Laitman
Sheba Medical Center, Tel Aviv, Israel.
Shani Paluch
SP
Shimon
Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Canada.
Jacques
J
Simard
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Douglas F
DF
Easton
Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America; Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
Kenneth
K
Offit
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America.
Fergus J
FJ
Couch
Department of Genetics and Computational Biology, Queensland Institute of Medical Research, Brisbane, Australia.
Georgia
G
Chenevix-Trench
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Antonis C
AC
Antoniou
Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain; Genotyping Unit (CeGen), Spanish National Cancer Centre (CNIO), Madrid, Spain.
Javier
J
Benitez
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D045647:DNA Glycosylases / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012306:Risk
D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human; D045647:DNA Glycosylases