Thermogenic effect of glucose in hypothyroid subjects.
The importance of thyroid hormone, catecholamines, and insulin in modification of the thermogenic effect of glucose (TEG) was examined in 34 healthy and 32 hypothyroid subjects. We calculated the energy expenditure at rest and during oral glucose tolerance test. Blood samples for determinations of glucose, plasma insulin, adrenaline (A), and noradrenaline (NA) were collected. It was found that TEG was lower in hypothyroid than in control group (19.68 ± 3.90 versus 55.40 ± 7.32 kJ, resp., P < 0.0004). Mean values of glucose and insulin areas under the curve were higher in women with hypothyroidism than in control group (286.79 ± 23.65 versus 188.41 ± 15.84 mmol/L·min, P < 0.003 and 7563.27 ± 863.65 versus 4987.72 ± 583.88 mU/L·min, P < 0.03 resp.). Maximal levels of catecholamines after glucose ingestion were higher in hypothyroid patients than in control subjects (Amax-0.69 ± 0.08 versus 0.30 ± 0.07 nmol/L, P < 0.0001, and NAmax-6.42 ± 0.86 versus 2.54 ± 0.30 nmol/L, P < 0.0002). It can be concluded that in hypothyroidism TEG and glucose tolerance are decreased while the adrenergic response to glucose administration is enhanced. Presumably, these changes are related to decreased insulin sensitivity and responsiveness to catecholamine action.
Mossakowski Medical Research Center, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.
Agnieszka
A
Kozacz
Mossakowski Medical Research Center, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.
Paulina
P
Grunt
Mossakowski Medical Research Center, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.
Marta
M
Steczkowska
Mossakowski Medical Research Center, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.
Tomasz
T
Mikulski
Mossakowski Medical Research Center, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.
Jan
J
Dąbrowski
Mossakowski Medical Research Center, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.
Monika
M
Górecka
Masovian Hospital Bródno, 8 Kondratowicza Street, 03-242 Warsaw, Poland.
Urszula
U
Sanocka
Mossakowski Medical Research Center, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.
Andrzej Wojciech
AW
Ziemba