5-FU induced acute toxic leukoencephalopathy: early recognition and reversibility on DWI-MRI.
Acute toxic leukoencephalopathy (ATL) is a rare adverse effect of 5-Fluorouracil (5-FU) chemotherapeutic agent. It is imperative for the radiologist to confidently identify the white matter changes caused by this agent in case of toxicity. This will help in early detection and appropriate management of patient, as the condition is reversible both clinically and on imaging. We report a case of a 29 years old gentleman, known case of carcinoma of esophagus who suffered from acute toxic leukoencephalopathy secondary to leukotoxic therapeutic agent 5-FU, and illustrate the reversible imaging findings of this condition on withdrawal of the inciting agent.
Department of Radiology, The Aga Khan University Hospital, Karachi.
Shayan Sirat
SS
Maheen Anwar
Department of Radiology, The Aga Khan University Hospital, Karachi.
Fatima
F
Mubarak
Department of Radiology, The Aga Khan University Hospital, Karachi.
Zafar
Z
Sajjad
Department of Radiology, The Aga Khan University Hospital, Karachi.
Muhammad
M
Azeemuddin
D000208:Acute Disease; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D038524:Diffusion Magnetic Resonance Imaging; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D056784:Leukoencephalopathies / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil