Psychophysical measurement of rod and cone thresholds in stargardt disease with full-field stimuli.
OBJECTIVE
To investigate psychophysical thresholds in Stargardt disease with the full-field stimulus test (FST).


METHODS
Visual acuity, spectral domain optical coherence tomography, full-field electroretinogram, and FST measurements were made in 1 eye of 24 patients with Stargardt disease. Dark-adapted rod FST thresholds were measured with short-wavelength stimuli, and cone FST thresholds were obtained from the cone plateau phase of dark adaptation using long-wavelength stimuli. Correlation coefficients were calculated for FST thresholds versus macular thickness, visual acuity, and electroretinogram amplitudes.


RESULTS
The Stargardt disease patients' FST cone thresholds correlated significantly with visual acuity, macular thickness, and electroretinogram cone response amplitudes (all P < 0.01). The patients' FST rod thresholds correlated with electroretinogram rod response amplitudes (P < 0.01) but not macular thickness (P = 0.05). All patients with Stargardt disease with flecks confined to the macula, and most of the patients with flecks extending outside of the macula had normal FST thresholds. All patients with extramacular atrophic changes had elevated FST cone thresholds and most had elevated FST rod thresholds.


CONCLUSIONS
Full-field stimulus test rod and cone threshold elevation in patients with Stargardt disease correlated well with measures of structure and function, as well as ophthalmoscopic retinal appearance. The Full-field stimulus test appears to be a useful tool for assessing rod and cone function in Stargardt disease.
*Pangere Center for Hereditary Retinal Diseases, The Chicago Lighthouse for People Who Are Blind or Visually Impaired, Chicago, Illinois; †Department of Ophthalmology, University of Illinois at Chicago, Chicago, Illinois; and Departments of ‡Ophthalmology, and §Pathology and Cell Biology, Columbia University, New York, New York.
Frederick T
FT
Collison
Gerald A
GA
Fishman
J Jason
JJ
McAnany
Jana
J
Zernant
Rando
R
Allikmets
D000328:Adult; D003623:Dark Adaptation; D004596:Electroretinography; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology*; D011601:Psychophysics; D012684:Sensory Thresholds / Q000502:physiology*; D000080362:Stargardt Disease; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult