Molecular tumorigenesis of the skin.
Skin tumors are supposed to develop through accumulations of genetic and/or epigenetic events in normal cells of the skin. Among them, we focus on common skin tumors, including benign, seborrheic keratosis, and malignant, squamous cell carcinoma and melanoma. Many important molecules have been detected on the molecular tumorigenesis of each of them to date, and some drugs targeted for their molecules have been already developed. We review updates on the molecular tumorigenesis of these tumors with our current works.
Department of Dermatology, Institute of Health Biosciences, the University of Tokushima Graduate School.
Yoshiaki
Y
Kubo
Yoshihiro
Y
Matsudate
Nozomi
N
Fukui
Ayaka
A
Nakasuka
Maiko
M
Sogawa
Mika
M
Oshima
Tomoya
T
Mizutani
Masanobu
M
Otsu
Kazutoshi
K
Murao
Ichiro
I
Hashimoto
D063646:Carcinogenesis / Q000235:genetics / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology; D044127:Epigenesis, Genetic / Q000235:genetics; D006801:Humans; D008545:Melanoma / Q000235:genetics / Q000473:pathology; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*