Improving outcomes in DCDD liver transplantation: there can only be strength in numbers.
In the United States, liver transplantation using donation after circulatory determination of death (DCDD) donors is challenged by persistently inferior graft survival compared with donation after neurological death (DND), along with declining rates of liver transplantation relative to the total number of DCDD donors. Advances in adult-to-adult living donor liver transplantation graft survival temporally related to the Adult-to-Adult Living Donor Liver Transplantation Cohort Study consortium suggest that a similarly focused collaborative effort may serve to stimulate evolution within DCDD liver transplantation. Without a multi-center consortium to support innovative trials, the current state of DCDD liver transplantation is unlikely to progress.
Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
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Goldberg
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Abt
D000328:Adult; D003643:Death; D046148:Donor Selection / Q000379:methods*; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D016031:Liver Transplantation; D009927:Tissue and Organ Procurement / Q000706:statistics & numerical data*
A2ALL; donor selection; ex vivo perfusion; living donor liver transplantation; warm ischemia