[Function of oesophagus and gastro-oesophageal reflux in patients with cystic fibrosis].
Gastro-oesophageal reflux (GER) has a special meaning for patients with cystic fibrosis (CF). Twelve voluntary patients with CF up to the age of 25 underwent an oesophageal manometry and a 24-hour impedance-pH monitoring. These patients were without symptoms of GER. The examination proved an acid GER in 42 %. In the total population the frequency is ≤ 10 %. In 11 of 12 patients a pathologically low pressure of the lower oesophageal sphincter (LES) was found. No significant correlations between the DeMeester score and the pressure of the LES, the reflux and respiratory symptomatology, the lung function as well as the quality of life could be proven. However, there was a significant correlation between the DeMeester score and the acid clearance time. 37 % of the registered cough pushes were related to a GER, of which 78 % were associated with an acid GER. Therefore, coughing in patients with CF must not necessarily be caused by the underlying disease. The timely detection of a pathological GER in patients with CF, but without symptoms of GER, and its prompt therapy could protect the lung function.
Klinik für Kinderchirurgie, Martin-Luther-Universität, Halle.
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S
Höhne
Klinik für Kinderchirurgie, Martin-Luther-Universität, Halle.
R
R
Wachter
Klinik für Kinder- und Jugendmedizin, Martin-Luther-Universität, Halle.
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N
Merkel
Klinik für Kinderchirurgie, Martin-Luther-Universität, Halle.
V
V
Hesse
Klinik für Kinderchirurgie, Martin-Luther-Universität, Halle.
R
R
Finke
D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D050782:Esophageal pH Monitoring; D004943:Esophagogastric Junction / Q000503:physiopathology*; D004947:Esophagus / Q000737:chemistry* / Q000503:physiopathology*; D005260:Female; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity