Impact of dietary modification of advanced glycation end products (AGEs) on the hormonal and metabolic profile of women with polycystic ovary syndrome (PCOS).
OBJECTIVE
To investigate the impact of dietary intervention on Advanced Glycation End products (AGEs) intake on the hormonal and metabolic profile in women with polycystic ovary syndrome (PCOS).


METHODS
After baseline evaluation, 23 women with PCOS [mean ± SD, age: 23.4 ± 5.7 years; body mass index (BMI): 26 ± 5.7 kg/m2] underwent the following consecutive 2-month dietary regimens: a hypocaloric diet with ad-libitum AGEs content (Hypo), an isocaloric diet with high AGEs (HA) and an isocaloric diet with low AGEs (LA). Metabolic, hormonal and oxidative stress status was assessed and AGEs levels were determined in all subjects after the completion of each dietary intervention.


RESULTS
Serum levels of AGEs, testosterone, oxidative stress, insulin and HOMA-IR index were significantly increased on the HA compared to the Hypo diet and subsequently decreased on the LA diet (compared to HA) (p<0.05 for all parameters). BMI remained unaltered throughout the HA and LA periods compared to the Hypo period. Serum AGEs were strongly correlated with insulin, as well as with HOMA, during the LA dietary period (r=0.53, p=0.02 and r=0.51, p=0.03, respectively). For the same period, dietary AGEs were correlated with insulin levels (rho=0.49, p=0.04).


CONCLUSIONS
Modifications of dietary AGEs intake are associated with parallel changes in serum AGEs, metabolic, hormonal and oxidative stress biomarkers in women with PCOS. These novel findings support recommendations for a low AGEs dietary content along with lifestyle changes in women with PCOS.
Endocrine Unit, Third Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Greece.
Evangelia
E
Tantalaki
Department of Biological Chemistry, University of Athens Medical School; Athens, Greece.
Christina
C
Piperi
Endocrine Unit, Third Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Greece.
Sarantis
S
Livadas
Endocrine Unit, Third Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Greece.
Anastasios
A
Kollias
Department of Biological Chemistry, University of Athens Medical School; Athens, Greece.
Christos
C
Adamopoulos
Endocrine Unit, Third Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Greece.
Aikaterini
A
Koulouri
Endocrine Unit, Third Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Greece.
Charikleia
C
Christakou
Endocrine Unit, Third Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Greece.
Evanthia
E
Diamanti-Kandarakis
D000293:Adolescent; D000328:Adult; D004038:Diet, Reducing; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000178:diet therapy; D013739:Testosterone / Q000097:blood; D055815:Young Adult
D017127:Glycation End Products, Advanced; D007328:Insulin; D013739:Testosterone