Mullinamides A and B, new cyclopeptides produced by the Ruth Mullins coal mine fire isolate Streptomyces sp. RM-27-46.
Two new cyclopeptides, mullinamides A [cyclo-(-L-Gly-L-Glu-L-Val-L-Ile-L-Pro-)] and B [cyclo-(-L-Glu-L-Met-L-Pro-)] were isolated from the crude extract of terrestrial Streptomyces sp. RM-27-46 along with the three known cyclopeptides surugamide A [cyclo-(-L-Ile-D-Ile-L-Lys-L-Ile-D-Phe-D-Leu-L-Ile-D-Ala-)], cyclo-(-L-Pro-L-Phe-) and cyclo-(-L-Pro-L-Leu-). The structures of the new compounds were elucidated by the cumulative analyses of NMR spectroscopy and HRMS. Although mullinamides A and B displayed no appreciable antimicrobial/fungal activity or cytotoxicity, this study highlights the first reported antibacterial activity of surugamide A.
1] Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, USA [2] Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Xiachang
X
Wang
1] Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, USA [2] Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Khaled A
KA
Shaaban
1] Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, USA [2] Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Sherif I
SI
Elshahawi
1] Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, USA [2] Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Larissa V
LV
Ponomareva
Division of Cardiovascular Medicine, University of Kentucky, Lexington, KY, USA.
Manjula
M
Sunkara
Center for Applied Energy Research, University of Kentucky, Lexington, KY, USA.
Gregory C
GC
Copley
Center for Applied Energy Research, University of Kentucky, Lexington, KY, USA.
James C
JC
Hower
Division of Cardiovascular Medicine, University of Kentucky, Lexington, KY, USA.
Andrew J
AJ
Morris
School of Pharmacy, University of Maryland Eastern Shore, Princess Anne, Maryland, USA.
Madan K
MK
Kharel
1] Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, USA [2] Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Jon S
JS
Thorson
D003032:Coal Mining; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000145:classification* / Q000302:isolation & purification / Q000378:metabolism*; D013302:Streptomyces / Q000145:classification* / Q000302:isolation & purification / Q000378:metabolism*
D010456:Peptides, Cyclic; C000594029:mullinamide A; C000594030:mullinamide B