Structural joint damage in gout.
This article summarizes the structural damage that is observed in advanced gout and current understanding of the mechanisms by which this damage occurs. Interactions between monosodium urate crystals and cells within the joint are described as well as knowledge gained from imaging studies. Future research directions and potential therapeutic strategies for the prevention and treatment of joint damage in gout are also discussed.
Bone & Joint Research Group, Department of Medicine, Faculty of Medical & Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand.
Ashika
A
Chhana
Bone & Joint Research Group, Department of Medicine, Faculty of Medical & Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: n.dalbeth@auckland.ac.nz.
Nicola
N
Dalbeth
D016723:Bone Remodeling / Q000502:physiology; D002356:Cartilage / Q000378:metabolism / Q000473:pathology*; D006073:Gout / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy / Q000378:metabolism; D007596:Joints / Q000378:metabolism / Q000473:pathology*; D010006:Osteoblasts; D010010:Osteoclasts; D014527:Uric Acid / Q000378:metabolism
D006074:Gout Suppressants; D014527:Uric Acid
Bone; Cartilage; Gout; Tendon; Urate crystal