Efficacy of catheter ablation of atrial fibrillation in patients with obstructive sleep apnoea with and without continuous positive airway pressure treatment: a meta-analysis of observational studies.
OBJECTIVE
An association between obstructive sleep apnoea (OSA) and atrial fibrillation (AF) has been established. However, studies on the role of OSA in AF recurrence after catheter ablation have yielded conflicting results, and the effect of OSA treatment by continuous positive airway pressure (CPAP) on the success rate of AF catheter ablation is indeterminate. The aim of this meta-analysis was to investigate the rate of AF recurrence after catheter ablation in patients with AF with or without OSA and to evaluate the relationship between CPAP therapy and AF recurrence.


RESULTS
We performed an online search and identified five studies involving 3743 patients with AF. Patients with OSA had a 31% greater risk of AF recurrence after catheter ablation than did patients without OSA [relative ratio (RR) = 1.31, P = 0.00], and this risk increased by 57% in patients with OSA not undergoing CPAP therapy (RR = 1.57, P = 0.00). However, CPAP users had a risk of AF recurrence similar to that of patients without OSA (RR = 1.25, P = 0.37), and this similarity was maintained even after the removal of study heterogeneity (RR = 0.99, P = 0.39).


CONCLUSIONS
Obstructive sleep apnoea was associated with AF recurrence after catheter ablation. The efficacy of catheter ablation for AF was similar between patients without OSA and patients with OSA undergoing CPAP treatment.
Cardiovascular Center, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China ellentmc2010@hotmail.com chshma@vip.sina.com.
Li
L
Li
State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Disease, CAMC and PUMC, Beijing, China.
Zeng-wu
ZW
Wang
Cardiovascular Center, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China.
Jie
J
Li
Cardiovascular Center, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China.
Xing
X
Ge
Cardiovascular Center, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China.
Li-zhu
LZ
Guo
Cardiovascular Center, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China.
Ying
Y
Wang
Cardiovascular Center, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China.
Wei-hua
WH
Guo
Cardiology Department, Atrial Fibrillation Center, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.
Chen-xi
CX
Jiang
Cardiovascular Center, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China Cardiology Department, Atrial Fibrillation Center, Beijing An Zhen Hospital, Capital Medical University, Beijing, China ellentmc2010@hotmail.com chshma@vip.sina.com.
Chang-sheng
CS
Ma
D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000601:surgery*; D017115:Catheter Ablation / Q000706:statistics & numerical data*; D015897:Comorbidity; D045422:Continuous Positive Airway Pressure / Q000706:statistics & numerical data*; D006801:Humans; D064887:Observational Studies as Topic; D015995:Prevalence; D012008:Recurrence; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology* / Q000628:therapy*; D016896:Treatment Outcome
Atrial fibrillation; Catheter ablation; Continuous positive airway pressure (CPAP); Meta-analysis; Sleep apnoea