Regulation of metabolism by long, non-coding RNAs.
Our understanding of genomic regulation was revolutionized by the discovery that the genome is pervasively transcribed, giving rise to thousands of mostly uncharacterized non-coding ribonucleic acids (ncRNAs). Long, ncRNAs (lncRNAs) have thus emerged as a novel class of functional RNAs that impinge on gene regulation by a broad spectrum of mechanisms such as the recruitment of epigenetic modifier proteins, control of mRNA decay and DNA sequestration of transcription factors. We review those lncRNAs that are implicated in differentiation and homeostasis of metabolic tissues and present novel concepts on how lncRNAs might act on energy and glucose homeostasis. Finally, the control of circadian rhythm by lncRNAs is an emerging principles of lncRNA-mediated gene regulation.
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases Köln, Germany ; Max-Planck-Institute for Neurological Research Köln, Germany.
Jan-Wilhelm
JW
Kornfeld
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases Köln, Germany ; Max-Planck-Institute for Neurological Research Köln, Germany ; Department of Mouse Genetics and Metabolism and Center for Molecular Medicine Cologne, Institute for Genetics at the University Hospital of Cologne, University of Cologne Cologne, Germany ; Center for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, University of Cologne, Cologne Germany.
Jens C
JC
Brüning
cell differentiation; glucose homeostasis; lncRNAs; metabolism and obesity; non-coding RNA (ncRNA)