Recurrent lymphadenopathy in children with Kikuchi-Fujimoto disease.
Kikuchi-Fujimoto disease (KFD) is characterized by self-limiting regional lymphadenopathy with prolonged fever. Although the reported recurrence rate of KFD is known to be 3-4 %, this rate appears to be higher in our clinical experience, and rates up to 38.5 % have been previously reported. In this retrospective study, we reviewed medical records of children with pathologically confirmed KFD to investigate the factors associated with recurrent KFD. Enrolled children were divided into two groups according to the recurrence of KFD, and clinical and laboratory factors were compared between the two groups. The recurrence of KFD was determined based not on repeated pathologic confirmation but on the presence of clinical febrile lymphadenopathy. A total of 33 children with KFD, 26 boys (78.8 %) and 7 girls (21.2 %), with a median age of 12 years (9 months to 19 years), were enrolled. Thirty-one children (93.9 %) complained of fever, and most of the children (90.9 %) complained of cervical lymphadenopathy. Neutropenia (<1,500/μL) or lymphopenia (<1,500/μL) was observed in 51.5 %. Lactate dehydrogenase level, erythrocyte sedimentation rate, and C-reactive protein level were elevated in 90.9, 96.9, and 54.5 % of children, respectively. Fourteen children (42.4 %) experienced recurrent KFD, including ten children after biopsy and four children before and after biopsy. In a multivariate analysis, a past history of other systemic illnesses (p = 0.013) and a higher absolute lymphocyte count (p = 0.023) were significantly associated with recurrent KFD. These systemic illnesses were chronic idiopathic thrombocytopenic purpura, autoimmune thyroiditis, nephrotic syndrome, perinatal cytomegalovirus infection, and hemophagocytic lymphohistiocytosis.


CONCLUSIONS
Our results suggest that recurrent KFD is more frequent than reported, and recurrent KFD should be considered in children with a history of other systemic illnesses such as immune disorders.
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, yoohymn@naver.com.
In Hyuk
IH
Yoo
Hyunju
H
Na
E Young
EY
Bae
Seung Beom
SB
Han
Soo Young
SY
Lee
Dae Chul
DC
Jeong
Jin Han
JH
Kang
D000293:Adolescent; D001365:Axilla / Q000473:pathology; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007223:Infant; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D009333:Neck / Q000473:pathology; D012008:Recurrence; D012189:Retrospective Studies