Total synthesis of dixiamycin B by electrochemical oxidation.
N-N-linked dimeric indole alkaloids represent an unexplored class of natural products for which chemical synthesis has no practical solution. To meet this challenge, an electrochemical oxidative dimerization method was developed, which was applied as the pivotal step of the first total synthesis of dixiamycin B. This method is also general for N-N dimerization of substituted carbazoles and β-carbolines, providing entry into seldom explored chemical space.
Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Brandon R
BR
Rosen
Erik W
EW
Werner
Alexander G
AG
O'Brien
Phil S
PS
Baran
D004563:Electrochemistry / Q000379:methods*; D010084:Oxidation-Reduction; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry
D012717:Sesquiterpenes; C000597254:dixiamycin B