Basaloid squamous cell carcinoma in the nasal cavity treated with proton beam therapy concurrent with cisplatin: a case report.
BACKGROUND
Basaloid squamous cell carcinoma is a rare and aggressive variant of squamous cell carcinoma. Basaloid squamous cell carcinoma is mostly seen in the upper aerodigestive tract and has a propensity for lymph node spread and systemic metastases. Various treatment modalities have been reported, including surgical excision supplemented with radiotherapy/adjuvant chemotherapy. To the best of our knowledge, treatment of nasal basaloid squamous cell carcinoma with proton beam therapy and cisplatin has not been described in the literature.


METHODS
We report the case of a 56-year-old Japanese man with locally invasive basaloid squamous cell carcinoma in his right nasal cavity with invasion of the orbit, paranasal sinus, and buccal subcutaneous tissue. He underwent proton beam therapy concurrent with cisplatin. Acute and late side effects did not exceed grade 3. At 24-month follow up, he remains in complete remission.


CONCLUSIONS
Proton beam therapy concurrent with cisplatin may be one choice for locally invasive basaloid squamous cell carcinoma.
Proton Therapy Center, Fukui Prefectural Hospital, 2-8-1 Yotsui, Fukui City, Fukui 910-8526, Japan. shigerad@staff.kanazawa-u.ac.jp.
Shigeyuki
S
Takamatsu
Kazutaka
K
Yamamoto
Tamaki
T
Kondou
Mariko
M
Kawamura
Satoko
S
Asahi
Yuuji
Y
Tameshige
Yoshikazu
Y
Maeda
Makoto
M
Sasaki
Hiroyasu
H
Tamamura
Akira
A
Tsuji
Yasuharu
Y
Kaizaki
Tomoyasu
T
Kumano
Tsuyoshi
T
Takanaka
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000628:therapy*; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000175:diagnosis / Q000628:therapy*; D049268:Positron-Emission Tomography; D061766:Proton Therapy / Q000379:methods*; D012074:Remission Induction; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; D002945:Cisplatin