Chemical constituents from Melastoma dodecandrum and their inhibitory activity on interleukin-8 production in HT-29 cells.
In search of anti-inflammatory lead compounds from traditional Chinese medicines, a bioassay-guided phytochemical study on Melastoma dodecandrum was carried out. As a result, 18 compounds have been isolated. Their chemical structures were determined on the basis of their physicochemical properties and spectral data. Among the isolates, three pentacyclic triterpenoids, ursolic acid (1), asiatic acid (3) and terminolic acid (6), together with one tannin casuarinin (17), were found to significantly decrease interleukin-8 (IL-8) production in human colon cancer cells. The results imply, at least in part, that the anti-inflammatory effect of M. dodecandrum could be due to inhibition of IL-8 production, demonstrated by these naturally occurring compounds described above.
a Department of Natural Products Chemistry , School of Pharmacy, Fudan University , No. 826 Zhangheng Road, Shanghai 201203 , P.R. China.
Guo-Xun
GX
Yang
Rui-Ze
RZ
Zhang
Bin
B
Lou
Ke-Jun
KJ
Cheng
Juan
J
Xiong
Jin-Feng
JF
Hu
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D047348:Hydrolyzable Tannins / Q000302:isolation & purification; D016209:Interleukin-8 / Q000187:drug effects* / Q000378:metabolism; D035322:Melastomataceae / Q000737:chemistry*; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry; D013634:Tannins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000097245:Ursolic Acid
D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D047348:Hydrolyzable Tannins; D016209:Interleukin-8; D053978:Pentacyclic Triterpenes; D013634:Tannins; D014315:Triterpenes; D000097245:Ursolic Acid; C472513:casuarinin; C017032:asiatic acid; C000593285:terminolic acid
Melastoma dodecandrum; Melastomataceae; anti-inflammatory; interleukin-8; tannin; triterpenoids