HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A.
A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-Δ32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using controls from the general population. Our data indicate that HLA class I alleles, presence or absence of KIR genes, and functionally relevant combinations of the HLA/KIR genotypes are not involved in resistance to parenterally transmitted HIV-1 infection.
Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Maryland Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.
Nicolas
N
Vince
Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Maryland Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.
Arman A
AA
Bashirova
Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.
Alexandra
A
Lied
Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Maryland.
Xiaojiang
X
Gao
Nuffield Department of Medicine, University of Oxford, United Kingdom.
Lucy
L
Dorrell
School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Paul J
PJ
McLaren
School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Jacques
J
Fellay
Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Maryland Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.
Mary
M
Carrington
D060467:Disease Resistance; D056726:Genetic Association Studies; D015658:HIV Infections / Q000276:immunology*; D006467:Hemophilia A / Q000150:complications*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D054340:Receptors, KIR / Q000276:immunology*
D015395:Histocompatibility Antigens Class I; D054340:Receptors, KIR
HESN; HIV-1; HLA; KIR; hemophilia