CuBr-promoted formal hydroacylation of 1-alkynes with glyoxal derivatives: an unexpected synthesis of 1,2-dicarbonyl-3-enes.
An efficient and concise protocol has been developed for the highly regio- and stereoselective synthesis of E-1,2-dicarbonyl-3-ene derivatives by a copper-promoted reaction of 1-alkynes with α-carbonyl aldehydes in the presence of morpholine. The products obtained are believed as the formal hydroacylation of the triple bond.
Department of Chemistry and Chemical Engineering, Inner Mongolia University , Hohhot 010021, People's Republic of China.
Shufeng
S
Chen
Xiaojie
X
Li
Haiying
H
Zhao
Baoguo
B
Li