A role for primate subgenual cingulate cortex in sustaining autonomic arousal.
The subgenual anterior cingulate cortex (subgenual ACC) plays an important role in regulating emotion, and degeneration in this area correlates with depressed mood and anhedonia. Despite this understanding, it remains unknown how this part of the prefrontal cortex causally contributes to emotion, especially positive emotions. Using Pavlovian conditioning procedures in macaque monkeys, we examined the contribution of the subgenual ACC to autonomic arousal associated with positive emotional events. After such conditioning, autonomic arousal increases in response to cues that predict rewards, and monkeys maintain this heightened state of arousal during an interval before reward delivery. Here we show that although monkeys with lesions of the subgenual ACC show the initial, cue-evoked arousal, they fail to sustain a high level of arousal until the anticipated reward is delivered. Control procedures showed that this impairment did not result from differences in autonomic responses to reward delivery alone, an inability to learn the association between cues and rewards, or to alterations in the light reflex. Our data indicate that the subgenual ACC may contribute to positive affect by sustaining arousal in anticipation of positive emotional events. A failure to maintain positive affect for expected pleasurable events could provide insight into the pathophysiology of psychological disorders in which negative emotions dominate a patient's affective experience.
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892.
Peter H
PH
Rudebeck
Philip T
PT
Putnam
Teresa E
TE
Daniels
Tianming
T
Yang
Andrew R
AR
Mitz
Sarah E V
SE
Rhodes
Elisabeth A
EA
Murray
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D003214:Conditioning, Classical; D006179:Gyrus Cinguli / Q000502:physiology*; D000882:Haplorhini / Q000502:physiology*; D011680:Pupil / Q000502:physiology
Area 25; anticipatory arousal; infralimbic; pupil size