Elevation of intra-abdominal pressure by pneumoperitoneum decreases pancreatic perfusion in an in vivo porcine model.
BACKGROUND
The goal of this study is to examine changes in pancreatic perfusion due to pneumoperitoneum using perfusion CT in vivo.


METHODS
Three pigs were studied. Under general anesthesia, pneumoperitoneum was induced to 16 mm Hg. Perfusion CT scans were acquired at a rate of 1 image per 2 seconds for 60 seconds. Scans were repeated 5 days later without pneumoperitoneum using the same protocol, in the same animals. The time density curve, color map, peak enhancement, time to peak, blood flow, blood volume, and permeability were evaluated.


RESULTS
In the presence of pneumoperitoneum, peak enhancement in radiodensity was decreased and time to peak was increased, and both blood flow and blood volume decreased. However, there was no consistent change in permeability observed.


CONCLUSIONS
This study demonstrates that pneumoperitoneum quantitatively results in decreased blood flow and blood volume to the pancreas in an in vivo animal model.
Departments of *Surgery †Radiology ‡The Center for Development of Advanced Medical Technology, Jichi Medical University, Tochigi, Japan.
Kazuhiro
K
Endo
Takahiro
T
Sasaki
Naohiro
N
Sata
Shuji
S
Hishikawa
Hideharu
H
Sugimoto
Alan T
AT
Lefor
Yoshikazu
Y
Yasuda
D034841:Abdominal Cavity / Q000503:physiopathology*; D000818:Animals; D002245:Carbon Dioxide / Q000008:administration & dosage; D004195:Disease Models, Animal; D007327:Insufflation; D010179:Pancreas / Q000098:blood supply* / Q000000981:diagnostic imaging; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects*; D011312:Pressure; D012039:Regional Blood Flow / Q000502:physiology*; D015427:Reperfusion Injury / Q000209:etiology / Q000503:physiopathology*; D013552:Swine; D014057:Tomography, X-Ray Computed
D002245:Carbon Dioxide