A new phenolic glycoside from Juglans mandshurica.
A new phenolic glycoside, 6-O-(4'-hydroxy-3',5'-dimethoxybenzoyl)-d-glucopyranose (4), and nine known compounds (1-3 and 5-10) were isolated from Juglans mandshurica Maxim. Compound structures were elucidated by NMR, HR-ESI-MS and acid hydrolysis. Compounds 5 and 6 are reported from this genus for the first time. Among compounds 1-10, only 1 exhibited cytotoxicity against MGC-803, A549, K562, JAR, HeLa, CaSKi and SiHa cell lines (IC50: 2.0, 5.3, 2.3, 6.9, 4.0, 6.6 and 2.7 μM, respectively).
a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules , Ministry of Education, Yanbian University College of Pharmacy , Yanji 133002 , China.
Dalei
D
Yao
Mei
M
Jin
Changhao
C
Zhang
Jie
J
Luo
Ren
R
Li
Mingshan
M
Zheng
Jiongmo
J
Cui
Gao
G
Li
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D031324:Juglans / Q000737:chemistry*; D020014:K562 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry
C000592867:6-O-(4'-hydroxy-3',5'-dimethoxybenzoyl)-d-glucopyranose; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D010636:Phenols
Juglandaceae; Juglans mandshurica; phenolic glycoside