Experimental study of image-guided percutaneous microwave ablation in rabbit lung VX2 tumor model.
OBJECTIVE
To investigate the efficacy and safety of percutaneous microwave ablation.


METHODS
Twenty-six rabbits with lung VX2 tumor were randomly divided into experimental and control group. In the experimental group, microwave ablation guided by ultrasound or CT was performed based on location of the tumor. Enhanced CT scan was carried out immediately before and after the ablation for all animals. Two animals from each group were sacrificed immediately or 1 week after the ablation respectively and the others were followed for the rest of their lives.


RESULTS
CT scan revealed that the tumor was greatly reduced or ablated after ablation. Pathological examination immediately after ablation also confirmed the tumor reduction or ablation. The survival time of the animals in the experimental group was significantly longer than that in the control group.


CONCLUSIONS
Microwave ablation is a safe and effective method for treating lung cancer in rabbits, showing potential clinical applicability.
Department of Ultrasound, Chinese General Hospital of Armed Police Forces No. 69 Yongding Road, Beijing 100039, China ; Department of Interventional Ultrasound, Chinese PLA General Hospital No. 28 Fuxing Road, Beijing 100853, China.
Xin
X
Li
Department of Ultrasound, Chinese General Hospital of Armed Police Forces No. 69 Yongding Road, Beijing 100039, China.
Weixing
W
Liu
Department of Ultrasound, Chinese General Hospital of Armed Police Forces No. 69 Yongding Road, Beijing 100039, China.
Haiyan
H
Kou
Department of Ultrasound, Chinese General Hospital of Armed Police Forces No. 69 Yongding Road, Beijing 100039, China.
Weihua
W
Zhou
Department of Ultrasound, Chinese General Hospital of Armed Police Forces No. 69 Yongding Road, Beijing 100039, China.
Tao
T
Li
Department of Interventional Ultrasound, Chinese PLA General Hospital No. 28 Fuxing Road, Beijing 100853, China.
Baowei
B
Dong
Department of Interventional Ultrasound, Chinese PLA General Hospital No. 28 Fuxing Road, Beijing 100853, China.
Ping
P
Liang
D000279:Administration, Cutaneous; D000818:Animals; D017115:Catheter Ablation / Q000379:methods*; D004195:Disease Models, Animal; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy; D008872:Microwaves / Q000627:therapeutic use*; D011817:Rabbits
Microwave ablation; VX2 tumor; lung cancer