Fetus dose estimation in thyroid cancer post-surgical radioiodine therapy.
Unrecognised pregnancy during radioisotope therapy of thyroid cancer results in hardly definable embryo/fetus exposures, particularly when the thyroid gland is already removed. Sources of such difficulty include uncertainty in data like pregnancy commencing time, amount and distribution of metastasized thyroid cells in body, effect of the thyroidectomy on the fetus dose coefficient etc. Despite all these uncertainties, estimation of the order of the fetus dose in most cases is enough for medical and legal decision-making purposes. A model for adapting the dose coefficients recommended by the well-known methods to the problem of fetus dose assessment in athyrotic patients is proposed. The model defines a correction factor for the problem and ensures that the fetus dose in athyrotic pregnant patients is less than the normal patients. A case of pregnant patient undergone post-surgical therapy by I-131 is then studied for quantitative comparison of the methods. The results draw a range for the fetus dose in athyrotic patients using the derived factor. This reduces the concerns on under- or over-estimation of the embryo/fetus dose and is helpful for personal and/or legal decision-making on abortion.
Nuclear Science & Technology Research Institute, End of North Kargar, Tehran, Iran Iran Nuclear Regulatory Authority, End of North Kargar, Tehran, Iran fmianji@aeoi.org.ir.
Fereidoun A
FA
Mianji
Iran Nuclear Regulatory Authority, End of North Kargar, Tehran, Iran.
Jila Karimi
JK
Diba
Nuclear Science & Technology Research Institute, End of North Kargar, Tehran, Iran Iran Nuclear Regulatory Authority, End of North Kargar, Tehran, Iran.
Asad
A
Babakhani
D005260:Female; D005333:Fetus / Q000378:metabolism / Q000528:radiation effects*; D005865:Gestational Age; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008431:Maternal-Fetal Exchange; D008954:Models, Biological; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000532:radiotherapy* / Q000601:surgery; D011829:Radiation Dosage; D019275:Radiopharmaceuticals / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013964:Thyroid Neoplasms / Q000150:complications* / Q000532:radiotherapy* / Q000601:surgery; D013965:Thyroidectomy
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals