[Recipient of living kidney transplantation during which heparin-induced thrombocytopenia (HIT) was suspected: a case report].
A 67-year-old woman with a diabetic renal failure was scheduled for a living kidney transplantation. Heparin was first used during hemodialysis 5 days before operation. Thrombocytopenia was found immediately after induction of general anesthesia, and the diagnosis of HIT was wade based on clinical symptom and 4 T's scoring. The surgery was continued because of the progress of donor surgery. Argatoroban was administered based on APTT measurement as an anticoagulation therapy during and after the operation. Although deep vein thrombosis was found 13 days after the operation, the transplanted kidney was established successfully. It is necessary to take a great caution in HIT development after heparin use.
Satoshi
S
Sakakibara
Ritsuko
R
Hirade
Toru
T
Mihara
Junichi
J
Ota
Tetsuro
T
Nikai
Yoji
Y
Saito
D000368:Aged; D000768:Anesthesia, General; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D000991:Antithrombins / Q000008:administration & dosage; D001120:Arginine / Q000031:analogs & derivatives; D003928:Diabetic Nephropathies / Q000601:surgery*; D057915:Drug Substitution; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors; D019990:Perioperative Care; D010875:Pipecolic Acids / Q000008:administration & dosage; D011183:Postoperative Complications / Q000517:prevention & control*; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis*; D013923:Thromboembolism / Q000517:prevention & control*; D016896:Treatment Outcome
D000925:Anticoagulants; D000991:Antithrombins; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban