Relationship of renin-angiotensin-aldosterone system polymorphisms and phenotypes to mortality in Chinese coronary atherosclerosis patients.
We performed a large, long-term cohort study to evaluate the association of renin-angiotensin-aldosterone system gene polymorphisms and baseline phenotypes to all-cause mortality among patients with angiographically confirmed coronary atherosclerosis. The study included 1075 subjects who underwent coronary angiography. Patients were genotyped for eight polymorphisms (rs4343, rs5186, rs5182, rs5049, rs5051, rs699, rs4762, and rs1799998), and their baseline plasma angiotensin II and aldosterone levels were measured. The interval between baseline and follow-up time-points ranged from 6.39 to 9.59 years. The results of multivariate regression analysis further indicated that high baseline angiotensin II levels (1.226 (1.024-1.468), p = 0.027) were independently associated with all-cause death. Therefore, we found that an increased baseline plasma angiotensin II level was associated with higher long-term all-cause mortality, even after correcting for established cardiovascular risk factors.
1] Department of cardiovascular medicine, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China [2].
En-Zhi
EZ
Jia
1] Department of Cardiovascular Medicine, the Friendship Hospital of Ili Kazakh Autonomous Prefecture, China [2].
Zhao-Hong
ZH
Chen
Department of Cardiovascular Medicine, the Friendship Hospital of Ili Kazakh Autonomous Prefecture, China.
Feng-Hui
FH
An
Department of Cardiovascular Medicine, the Friendship Hospital of Ili Kazakh Autonomous Prefecture, China.
Li-Hua
LH
Li
Department of cardiovascular medicine, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Li-Li
Department of cardiovascular medicine, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Chang-Yan
CY
Guo
Department of cardiovascular medicine, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Yan
Y
Gu
Department of cardiovascular medicine, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Zhe
Z
Liu
Department of cardiovascular medicine, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Zhao-Yang
ZY
Li
Department of cardiovascular medicine, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Tie-Bing
TB
Zhu
Department of cardiovascular medicine, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Lian-Sheng
LS
Wang
Department of cardiovascular medicine, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Chun-Jian
CJ
Li
Department of cardiovascular medicine, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Xiang-Qing
XQ
Kong
Department of cardiovascular medicine, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Wen-Zhu
WZ
Ma
Department of cardiovascular medicine, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Zhi-Jian
ZJ
Yang
D000368:Aged; D000450:Aldosterone / Q000097:blood; D000483:Alleles; D000804:Angiotensin II / Q000097:blood; D044466:Asian People / Q000235:genetics*; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012084:Renin-Angiotensin System / Q000235:genetics*; D012307:Risk Factors
D000804:Angiotensin II; D000450:Aldosterone