Enantioselective imine reduction catalyzed by imine reductases and artificial metalloenzymes.
Adding value to organic synthesis. Novel imine reductases enable the enantioselective reduction of imines to afford optically active amines. Likewise, novel bioinspired artificial metalloenzymes can perform the same reaction as well. Emerging proof-of-concepts are herein discussed.
Organic Chemistry Department, Universidad de la República (UdelaR), Gral. Flores 2124, 11800 Montevideo, Uruguay. dgamenar@fq.edu.uy.
Daniela
D
Gamenara
Pablo
P
Domínguez de María
D055162:Biocatalysis; D001710:Biotin / Q000378:metabolism; D007097:Imines / Q000737:chemistry / Q000378:metabolism*; D008667:Metalloproteins / Q000378:metabolism*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism*; D013237:Stereoisomerism; D019809:Streptavidin / Q000378:metabolism
D007097:Imines; D008667:Metalloproteins; D001710:Biotin; D019809:Streptavidin; D010088:Oxidoreductases