The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children.
We investigated the relation of serum leptin, soluble leptin receptor (sLR) and free leptin index (FLI) with metabolic and anthropometric parameters in obese and healthy children. Height, weight, waist circumference (WC), fasting serum glucose, insulin, lipid profile, leptin and sLR levels of 35 obese children and 36 healthy children were measured and FLI was calculated as the ratio of leptin to sLR. In obese children, serum leptin and FLI were found significantly higher, while sLR level was significantly lower than the healthy children. Comparison of obese children regarding the insulin resistance showed significantly higher serum leptin and FLI in the insulin resistant group; however sLR level was not different between the insulin resistant and non-resistant obese children. In obese children, sLR was not correlated with any of the metabolic parameters except total cholesterol, while FLI was significantly and positively correlated with BMI, WC, TC, fasting insulin, and HOMA-IR. However, regression analysis confirmed that the HOMA-IR was the only independent variable significantly correlated with FLI in obese children. Findings of this study suggest that in obese children and adolescents (i) serum leptin and FLI were found significantly higher, while sLR level was significantly lower than the healthy children, (ii) increased FLI might be a compensatory mechanism for increasing leptin effect in peripheral tissue, (iii) FLI is a more accurate marker to evaluate leptin resistance than leptin or sLR alone, and (iv) increased FLI may contribute toward the development of hyperinsulinemia and insulin resistance.
Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
Gonul
G
Catli
Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
Ahmet
A
Anik
Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
Hale Ünver
HÜ
Tuhan
Department of Biochemistry, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
Tuncay
T
Kume
Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
Ece
E
Bober
Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. Electronic address: ayhanabaci@gmail.com.
Ayhan
A
Abaci
D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood*; D054411:Receptors, Leptin / Q000097:blood*; D055105:Waist Circumference / Q000502:physiology
D007328:Insulin; D020738:Leptin; D054411:Receptors, Leptin
Childhood; Insulin resistance; Leptin; Obesity; Soluble leptin receptor