Level of thyroid-stimulating hormone (TSH) in patients with acute schizophrenia, unipolar depression or bipolar disorder.
The aim of this study is to investigate differences in thyroid-stimulating hormone (TSH) level in patients with acute schizophrenia, unipolar depression, bipolar depression and bipolar mania. Serum level of TSH was measured in 1,685 Caucasian patients (1,064 women, 63.1%; mean age 46.4). Mean serum TSH concentration was: schizophrenia (n = 769) 1.71 μIU/mL, unipolar depression (n = 651) 1.63 μIU/mL, bipolar disorder (n = 264) 1.86 μIU/mL, bipolar depression (n = 203) 2.00 μIU/mL, bipolar mania (n = 61) 1.38 μIU/mL (H = 11.58, p = 0.009). Depending on the normal range used, the overall rate of being above or below the normal range was 7.9-22.3% for schizophrenia, 13.9-26.0% for unipolar depression, 10.8-27.6% for bipolar disorder, 12.2-28.5% for bipolar depression, and 11.4-24.5% for bipolar mania. We have also found differences in TSH levels between the age groups (≤20, >20 years and ≤40, >40 years and ≤60 years and >60 years). TSH level was negatively correlated with age (r = -0.23, p < 0.001). Weak correlations with age have been found in the schizophrenia (r = -0.21, p < 0.001), unipolar depression (r = -0.23, p < 0.001), bipolar depression (r = -0.25, p = 0.002) and bipolar disorder (r = -0.21, p = 0.005) groups. Our results confirm that there may be a higher prevalence of thyroid dysfunctions in patients with mood disorders (both unipolar and bipolar) and that these two diagnostic groups differ in terms of direction and frequency of thyroid dysfunctions.
Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Czechosłowacka 8/10, 92-216, Lodz, Poland, adam.wysokinski@gmail.com.
Adam
A
Wysokiński
Iwona
I
Kłoszewska
D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis; D013972:Thyrotropin / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; D013972:Thyrotropin