An E3 ubiquitin ligase-independent role of LUBAC.
In this issue of Blood, Dubois et al show a catalytic-independent role of the linear ubiquitin chain assembly complex (LUBAC) in lymphocyte activation and B-cell malignancy.1 These data add a new layer of versatility to the recently established role of LUBAC in nuclear factor-kB (NF-kB) signaling.
GHENT UNIVERSITY;
Rudi
R
Beyaert
D006801:Humans; D008223:Lymphoma / Q000378:metabolism*; D016328:NF-kappa B / Q000737:chemistry* / Q000378:metabolism*; D054730:Protein Interaction Domains and Motifs / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*
D016328:NF-kappa B; D011948:Receptors, Antigen, T-Cell; D025801:Ubiquitin