Viral and cellular FLICE-inhibitory proteins: a comparison of their roles in regulating intrinsic immune responses.
FLICE-inhibitory proteins (FLIPs) are a family of viral (poxvirus and herpesvirus) and cellular proteins. The hallmark of this family is the presence of tandem death-effector domains (DEDs). Despite this shared motif, each protein possesses different abilities to modulate apoptosis, NF-κB, and interferon regulatory factor 3 (IRF3). These similarities and differences are discussed and highlighted here. The comparative study of FLIPs provides a unique basis to understand virus-host interactions, viral pathogenesis, and cellular regulation of immune system signal transduction pathways.
Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA jshisler@illinois.edu.
Joanna L
JL
Shisler
D017209:Apoptosis; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007109:Immunity; D050838:Interferon Regulatory Factor-3 / Q000235:genetics / Q000276:immunology; D005810:Multigene Family; D016328:NF-kappa B / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology* / Q000821:virology*; D014780:Viruses / Q000737:chemistry / Q000235:genetics / Q000276:immunology*
D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D050838:Interferon Regulatory Factor-3; D016328:NF-kappa B; D014764:Viral Proteins