Unlikely suspects identified in neuroblastoma conspiracy.
KIF1B is a candidate tumor-suppressor gene in neuroblastoma whose function is to mediate apoptosis when nerve growth factor becomes limiting in the developing nervous system. Chen and colleagues now provide mechanistic insight into how one of the protein products of this locus, KIF1Bβ, induces apoptosis.
Division of Molecular Carcinogenesis and Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Rene
R
Bernards
D000818:Animals; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D006801:Humans; D016547:Kinesins / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D020932:Nerve Growth Factor / Q000235:genetics*; D009447:Neuroblastoma / Q000235:genetics*
D009363:Neoplasm Proteins; D020932:Nerve Growth Factor; D053487:DEAD-box RNA Helicases; D016547:Kinesins