Myxofibrosarcoma of the thyroid gland.
BACKGROUND
Myxofibrosarcoma of the thyroid is exceptional: a Medline search found a single case report. We report a new case which raised diagnostic and therapeutic problems.


METHODS
We report the case of a 74-year-old woman who presented with swelling of the left thyroid lobe and ipsilateral cervical lymphadenopathy. Total thyroidectomy with cervical lymph-node dissection was performed. Histological analysis diagnosed myxofibrosarcoma. Evolution was marked by rapid local recurrence, and chemotherapy based on doxorubicin and ifosfamide was introduced.


CONCLUSIONS
Head and neck myxofibrosarcoma is rare. MRI is essential and should always precede treatment. Diagnosis is histological. There is elevated risk of local recurrence after resection, accompanied by worsening tumor grade, whence the need for accurate diagnosis, appropriate treatment and regular MRI follow-up.
Service d'Oto-Rhino-Laryngologie, Hôpital Militaire d'Instruction Mohammed V, avenue des FAR Hay Riad, 10000 Rabat, Morocco. Electronic address: daryou@yahoo.fr.
Y
Y
Darouassi
Service d'Oto-Rhino-Laryngologie, Hôpital Militaire d'Instruction Mohammed V, avenue des FAR Hay Riad, 10000 Rabat, Morocco.
H
H
Attifi
Service d'Oto-Rhino-Laryngologie, Hôpital Militaire d'Instruction Mohammed V, avenue des FAR Hay Riad, 10000 Rabat, Morocco.
M
M
Zalagh
Service d'Anatomie Pathologique, Hôpital Militaire d'Instruction Mohammed V, avenue des FAR Hay Riad, 10000 Rabat, Morocco.
I
I
Rharrassi
Service d'Oto-Rhino-Laryngologie, Hôpital Militaire d'Instruction Mohammed V, avenue des FAR Hay Riad, 10000 Rabat, Morocco.
F
F
Benariba
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008197:Lymph Node Excision; D009364:Neoplasm Recurrence, Local; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000628:therapy; D013965:Thyroidectomy
D004317:Doxorubicin; D007069:Ifosfamide
Myxofibrosarcoma; Sarcoma; Thyroid