[A case-control study on the risk factors of hepatocellular carcinoma in Guizhou Province].
OBJECTIVE
To determine the risk factor of HCC in Guizhou.


METHODS
A group case-control study design was conducted between 762 cases and 798 controls in Guizhou province. The main related-factors were analyzed with unconditional logistic regression model and evaluated by odds ratio (OR) and 95% confidence interval (95% CI).


RESULTS
There are significant differences between cases and controls in regarding to cigarette smoking 210 (27.6%),non-alcoholic fatty liver disease 336 (44.1%), alcoholic liver disease 245 (32.2%), family history of HCC 141 (16.5%), alcohol consumption 300 (39.4%), HBV infection 436 (57.2%), pickled food 290 (38.1%), and economic status 5 years ago 420 (55.1%) in cases,and cigarette smoking 116 (14.5%),non-alcoholic fatty liver disease 160 (20.1%), alcoholic liver disease 101 (12.7%), family history of HCC 40 (5.0%), alcohol consumption 180 (22.6%), HBV infection 82 (10.3%), pickled food 225 (28.2%), and economic status 5 years ago 647 (81.1%) in controls, with OR of each variable was 3.520, 2.464, 4.330, 2.219, 2.451, 19.245, 6.212, 0.174 respectively, P less than 0.01.


CONCLUSIONS
HBV infection and pickled food were the most common risks for HCC in Guizhou. Alcohol consumption excessively and cigarette smoking may increase the risk too.
Department of Infectious Disease, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China.
Xueke
X
Zhao
Mingliang
M
Cheng
Quan
Q
Zhang
Shasha
S
Chen
Jiawu
J
Tan
Wenzhi
W
Wang
Xinhua
X
Luo
Sandu
S
Liu
Shide
S
Lin
Wenling
W
Wang
Zhong
Z
Li
Hong
H
Sun
Jiahui
J
Ning
Rong
R
Chen
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005247:Feeding Behavior; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult