MR evaluation of breast lesions obtained by diffusion-weighted imaging with background body signal suppression (DWIBS) and correlations with histological findings.
OBJECTIVE
Diffusion imaging represents a new imaging tool for the diagnosis of breast cancer. This study aims to investigate the role of diffusion-weighted MRI with background body signal suppression (DWIBS) for evaluating breast lesions.


METHODS
90 patients were prospectively evaluated by MRI with STIR, TSE-T2, contrast enhanced THRIVE-T1 and DWIBS sequences. DWIBS were analyzed searching for the presence of breast lesions and calculating the ADC value. ADC values of ≤1.44×10(-3)mm(2)/s were considered suspicious for malignancy. This analysis was then compared with the histological findings. Sensitivity, specificity, diagnostic accuracy (DA), positive predictive value (PPV) and negative (NPV) were calculated.


RESULTS
In 53/90 (59%) patients, DWIBS indicated the presence of breast lesions, 16 (30%) with ADC values of >1.44 and 37 (70%) with ADC≤1.44. The comparison with histology showed 25 malignant and 28 benign lesions. DWIBS sequences obtained sensitivity, specificity, DA, PPV and NPV values of 100, 82, 87, 68 and 100%, respectively.


CONCLUSIONS
DWIBS can be proposed in the MRI breast protocol representing an accurate diagnostic complement.
Interdisciplinary Department of Medicine - Section of Diagnostic Imaging - Aldo Moro University of Bari Medical School, Piazza Giulio Cesare 11, 70124 Bari, Italy. Electronic address: marco.moschetta@gmail.com.
Marco
M
Moschetta
Interdisciplinary Department of Medicine - Section of Diagnostic Imaging - Aldo Moro University of Bari Medical School, Piazza Giulio Cesare 11, 70124 Bari, Italy.
Michele
M
Telegrafo
Interdisciplinary Department of Medicine - Section of Diagnostic Imaging - Aldo Moro University of Bari Medical School, Piazza Giulio Cesare 11, 70124 Bari, Italy.
Leonarda
L
Rella
Interdisciplinary Department of Medicine - Section of Diagnostic Imaging - Aldo Moro University of Bari Medical School, Piazza Giulio Cesare 11, 70124 Bari, Italy.
Arcangela
A
Capolongo
Interdisciplinary Department of Medicine - Section of Diagnostic Imaging - Aldo Moro University of Bari Medical School, Piazza Giulio Cesare 11, 70124 Bari, Italy.
Amato Antonio
AA
Stabile Ianora
Interdisciplinary Department of Medicine - Section of Diagnostic Imaging - Aldo Moro University of Bari Medical School, Piazza Giulio Cesare 11, 70124 Bari, Italy.
Giuseppe
G
Angelelli
D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008327:Mammography; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary
D003287:Contrast Media
Breast; DWIBS; Diffusion; MRI; Magnetic resonance