Microwave assisted synthesis and anti-lipase activity of some new fluorine-containing benzimidazoles.
In this study, a new series of fluorine containing benzimidazoles (4a-l) and bisbenzimidazoles (6a-c, 8) were synthesized by the reaction of o-phenylenediamines with iminoester hydrochlorides (3a-l, 7) in methanol under microwave irradiation. The structures of these newly synthesized compounds were identified by IR, (1)H-NMR, (13)C-NMR, mass spectroscopy and elemental analysis data. The synthesized compounds were screened for their pancreatic lipase activities. Our results indicate that the compounds 6a, 6b and 6c can serve as an anti-lipase agent. The compounds 6b and 6c inhibited pancreatic lipase activity by 84.03% and 97.49% at a concentration of 3 µg/mL, respectively.
Department of Chemistry,Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey.
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Menteşe
Department of Chemistry,Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey.
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Yilmaz
Department of Biology, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey.
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Ülker
Department of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Turkey.
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Kahveci
D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005461:Fluorine / Q000737:chemistry; D008049:Lipase / Q000037:antagonists & inhibitors*; D008872:Microwaves; D013057:Spectrum Analysis; D013552:Swine
D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D005461:Fluorine; D008049:Lipase