The role of notch signaling in bone marrow niche.
OBJECTIVE
Bone marrow (BM) niche is a three-dimensional structure composed of a series of cells and it is one of the most controversial topics in hematological malignancies, leukemia, and even metastasis. Here, we review the relationship between Notch signaling and different fates of stem cells and other BM niche cells.


METHODS
Relevant English-language literature were searched and retrieved from PubMed (2000-2013) using the terms Notch signaling, BM niche, and microRNAs (miRNAs).


CONCLUSIONS
Notch signaling pathway is a signaling system involved in cellular processes such as proliferation, differentiation, and apoptosis. The notch signaling pathway components are associated with interaction between leukemic, metastatic, and normal cells and their microenvironment. miRNAs play an important role in expression and regulation of signaling molecules. It is necessary to evaluate the relationship between aberrant miRNA expression and notch signaling such as miR-128 and miR-30 in glioma and angiogenesis with notch signaling, respectively.


CONCLUSIONS
Characterizing malignant cells and future studies focus on better understanding the variety of cancers and apoptosis with activated Notch signaling pathway, may remain promising this signaling system as a safe and effective therapeutic target.
Shirin
S
Azizidoost
Mehrnoosh Shanaki
MS
Bavarsad
Mahsa Shanaki
MS
Bavarsad
Saeid
S
Shahrabi
Kaveh
K
Jaseb
Fakher
F
Rahim
Mohammad
M
Shahjahani
Fakhredin
F
Saba
Mahdi
M
Ghorbani
Najmaldin
N
Saki
D001853:Bone Marrow / Q000378:metabolism* / Q000473:pathology; D001854:Bone Marrow Cells / Q000378:metabolism* / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D051880:Receptors, Notch / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D055153:Stem Cell Niche / Q000235:genetics*
C545189:MIRN128 microRNA, human; C546086:MIRN30b microRNA, human; D035683:MicroRNAs; D051880:Receptors, Notch
Bone marrow niche; Hematopoietic stem cell; Mesenchymal stem cell; Metastasis; Notch signaling; miRNA