10p12.31-12.2 variants and risk of childhood acute lymphoblastic leukemia in a Chinese population.
Acute lymphoblastic leukemia (ALL) is a clonal hematologic disease, and is the most common cause of childhood malignancy. Recently, a new locus was identified at 10p12.31-12.2 through a genome-wide association study (GWAS) that included racially and ethnically diverse populations. We conducted a replication study with 570 cases of ALL and 673 cancer-free controls to validated the association of this locus with ALL susceptibility in a Chinese population. The results of our study confirmed that the 10p12.31-12.2 locus was linked to childhood ALL susceptibility in the Chinese population. Interestingly, we also found that the single nucleotide polymorphisms (SNPs) in this locus had a larger effect on susceptibility to high-risk ALL than on susceptibility to low-risk ALL.
Department of Hematology and Oncology, Nanjing Children's Hospital Affiliated to Nanjing Medical University , Nanjing , China.
Jianping
J
Deng
Yao
Y
Xue
Yaping
Y
Wang
Jing
J
Chen
Jie
J
Li
Qin
Q
Lu
Meilin
M
Wang
Na
N
Tong
Zhengdong
Z
Zhang
Yongjun
Y
Fang
D000293:Adolescent; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D002879:Chromosomes, Human, Pair 10; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
10p12.31-12.2; childhood ALL; risk; verification