Genetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate-induced Asthma.
OBJECTIVE
To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA).


METHODS
The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels.


RESULTS
The HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under dominant (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.37 to 16.6; OR, 2.79, 95% CI, 0.99 to 7.81, respectively) and recessive genetic models (OR, 6.27, 95% CI, 1.63 to 24.13; OR, 10.10, 95% CI, 3.16 to 32.33, respectively). The HLA-B rs1811197, HLA-DOA rs3128935, and HLA-DQA2 rs7773955 SNPs conferred an increased risk of DA in a dominant model (OR, 7.64, 95% CI, 2.25 to 26.00; OR, 19.69, 95% CI, 2.89 to 135.25; OR, 8.43, 95% CI, 3.03 to 23.48, respectively).


CONCLUSIONS
These results suggest that genetic variations within HLA genes play a role in DA risk.
From the Health Effects Laboratory Division (Drs Yucesoy and Kashon, Ms Frye, and Ms Wang) NIOSH/CDC, Morgantown, WVa; BRT-Burleson Research Technologies (Dr Johnson), Morrisville, NC; Division of Immunology, Allergy and Rheumatology, Department of Medicine (Drs Yucesoy, Lummus, and Bernstein) and Department of Environmental Health (Drs Rao and Bannerman-Thompson), University of Cincinnati, Ohio; Hôpital du Sacré-Cœur de Montréal (Drs Gautrin and Cartier), Université de Montréal; Hôpital Laval (Dr Boulet), Université Laval, Sainte-Foy, Québec, Canada; Department of Allergy (Dr Sastre), Fundación Jiménez Díaz and CIBER de Enfermedades Respiratorias CIBERES; Department of Allergy (Dr Quirce), Hospital La Paz-IdiPAZ and CIBER de Enfermedades Respiratorias CIBERES, Madrid, Spain; Department of Medicine (Dr Tarlo), University of Toronto, Ontario, Canada; Toxicology Branch (Dr Germolec), DNTP/NIEHS, Research Triangle Park, NC; and School of Public Health (Dr Luster), West Virginia University, Morgantown.
Berran
B
Yucesoy
Victor J
VJ
Johnson
Zana L
ZL
Lummus
Michael L
ML
Kashon
Marepalli
M
Rao
Hansen
H
Bannerman-Thompson
Bonnie
B
Frye
Wei
W
Wang
Denyse
D
Gautrin
André
A
Cartier
Louis-Philippe
LP
Boulet
Joaquin
J
Sastre
Santiago
S
Quirce
Susan M
SM
Tarlo
Dori R
DR
Germolec
Michael I
MI
Luster
David I
DI
Bernstein
D000328:Adult; D001249:Asthma / Q000139:chemically induced* / Q000235:genetics; D005260:Female; D005805:Genes, MHC Class I / Q000235:genetics*; D005802:Genes, MHC Class II / Q000235:genetics*; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D017953:Isocyanates / Q000633:toxicity*; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000235:genetics; D016273:Occupational Exposure / Q000009:adverse effects*; D020641:Polymorphism, Single Nucleotide; D012306:Risk
D017953:Isocyanates