Myocardial blood flow quantification for evaluation of coronary artery disease by positron emission tomography, cardiac magnetic resonance imaging, and computed tomography.
The noninvasive detection of the presence and functional significance of coronary artery stenosis is important in the diagnosis, risk assessment, and management of patients with known or suspected coronary artery disease. Quantitative assessment of myocardial perfusion can provide an objective and reproducible estimate of myocardial ischemia and risk prediction. Positron emission tomography, cardiac magnetic resonance, and cardiac computed tomography perfusion are modalities capable of measuring myocardial blood flow and coronary flow reserve. In this review, we will discuss the technical aspects of quantitative myocardial perfusion imaging with positron emission tomography, cardiac magnetic resonance imaging, and computed tomography, and its emerging clinical applications.
Non-Invasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Alfonso H
AH
Waller
Ron
R
Blankstein
Raymond Y
RY
Kwong
Marcelo F
MF
Di Carli
D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis*; D003326:Coronary Circulation; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis*; D055414:Myocardial Perfusion Imaging; D018579:Patient Selection; D049268:Positron-Emission Tomography; D015203:Reproducibility of Results; D018570:Risk Assessment; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed