Urinary lysosomal enzyme excretion in pregnant women with hypertensive disorders.
BACKGROUND
The authors assessed proximal renal tubular dysfunction and/or damage in pregnant women with various types of hypertension by measuring the three urinary lysosomal enzyme levels: N-acetyl-β-d-glucosaminidase (NAG), arylsulfatase A and β-glucuronidase.


METHODS
The study consisted of 120 pregnant women divided into four groups: 41 women in 20th week of gestation or more, with pregnancy-induced hypertension (PIH group), 28 pregnant women after 20 weeks of pregnancy with pre-eclampsia (PE group), 21 pregnant women with chronic hypertension, identified before 20th week of pregnancy (CH group) and 30 healthy, pregnant women (healthy controls (HC) group).


RESULTS
Statistical analysis showed significantly higher levels of all the three of lysosomal enzymes in the urine of patients with PE compared with the healthy pregnant women, pregnant women with PIH and the ones with chronic hypertension. Additionally, significantly higher values of NAG were found in the group of pregnant women with PIH compared with healthy pregnancies. No correlation was found between the concentration of enzymes in urine and values of blood pressure in any of the analyzed groups of pregnant women.


CONCLUSIONS
The authors conclude that higher values of all the studied enzymes in PE group, in the comparison with the other groups, indicate proximal tubular damage at the cellular level. The lack of correlation between the concentration of lysosomal enzymes and blood pressure suggests that the damage to these parts of kidney is complex. In addition, mechanisms other than hypertension realizing intracellular enzymes may be involved in this process.
Department of Obstetrics and Gynecology .
Andrzej
A
Torbé
Ewelina
E
Chłapowska
Jolanta
J
Szymańska-Pasternak
Aneta
A
Sulecka
Joanna
J
Bober
Ewa
E
Kwiatkowska
Sebastian
S
Kwiatkowski
Rafał
R
Rzepka
Wioletta
W
Konstanty-Kurkiewicz
Bogdan
B
Torbé
D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D002553:Cerebroside-Sulfatase / Q000652:urine*; D005260:Female; D005966:Glucuronidase / Q000652:urine*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000201:enzymology* / Q000652:urine; D011247:Pregnancy; D055815:Young Adult
D002553:Cerebroside-Sulfatase; D005966:Glucuronidase; D000118:Acetylglucosaminidase
Hypertension; Lysosomal enzymes; Pre-eclampsia; Pregnancy