Identification of thyroid carcinoma related genes with mRMR and shortest path approaches.
Thyroid cancer is a malignant neoplasm originated from thyroid cells. It can be classified into papillary carcinomas (PTCs) and anaplastic carcinomas (ATCs). Although ATCs are in an very aggressive status and cause more death than PTCs, their difference is poorly understood at molecular level. In this study, we focus on the transcriptome difference among PTCs, ATCs and normal tissue from a published dataset including 45 normal tissues, 49 PTCs and 11 ATCs, by applying a machine learning method, maximum relevance minimum redundancy, and identified 9 genes (BCL2, MRPS31, ID4, RASAL2, DLG2, MY01B, ZBTB5, PRKCQ and PPP6C) and 1 miscRNA (miscellaneous RNA, LOC646736) as important candidates involved in the progression of thyroid cancer. We further identified the protein-protein interaction (PPI) sub network from the shortest paths among the 9 genes in a PPI network constructed based on STRING database. Our results may provide insights to the molecular mechanism of the progression of thyroid cancer.
Department of Otolaryngology head and neck surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Yaping
Y
Xu
Department of Otolaryngology head and neck surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Yue
Y
Deng
Department of Otolaryngology head and neck surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Zhenhua
Z
Ji
Department of Otolaryngology head and neck surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Haibin
H
Liu
Department of Otolaryngology head and neck surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Yueyang
Y
Liu
Department of Otolaryngology head and neck surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Hu
H
Peng
Department of Otolaryngology head and neck surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Jian
J
Wu
Department of Otolaryngology head and neck surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Jingping
J
Fan
D000465:Algorithms; D002277:Carcinoma / Q000235:genetics*; D002291:Carcinoma, Papillary / Q000235:genetics*; D052138:Genes, Neoplasm; D056726:Genetic Association Studies; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D060066:Protein Interaction Maps; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D013961:Thyroid Gland / Q000737:chemistry; D013964:Thyroid Neoplasms / Q000235:genetics*; D046888:Tissue Array Analysis; D059467:Transcriptome
D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm