Evaluation of ALS assay of TB-SA for diagnosis of pulmonary tuberculosis.
The study evaluated tuberculosis specific antigen (TB-SA) antibody in lymphocyte supernatant (ALS) assay for diagnosis of pulmonary tuberculosis (PTB). The mean concentration of TB-SA ALS in PTB patients was significantly higher than that of two control groups (non-PTB patients and healthy subjects, P < 0.001). The area under the curve of the ALS assay were 0.960 (0.904-0.988, PTB vs healthy subjects), and were 0.822 (0.739-0.887, PTB vs Non-PTB patients), respectively. Our data indicated the ALS assay for TB-SA can be used as a screening test and is a useful adjunct to current tests for diagnosis of PTB.
a Department of Lab Medicine , Shandong Provincial Chest Hospital , Jinan City , PR China.
Jin
J
Jiao
Mao-Shui
MS
Wang
Xiao-Guang
XG
Yang
Xin-Feng
XF
Wang
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D001681:Biological Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology; D008297:Male; D008654:Mesothelioma / Q000276:immunology; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000276:immunology; D055815:Young Adult
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007074:Immunoglobulin G
antibodies in lymphocyte supernatants; diagnosis; mycobacterium tuberculosis; pulmonary tuberculosis; specific antigen