Factors associated with diarrhoea in young children and incidence of symptomatic rotavirus infection in rural West Bengal, India.
Socio-behavioural factors and pathogens associated with childhood diarrhoea are of global public health concern. Our survey in 696 children aged ⩽2 years in rural West Bengal detected rotavirus as sole pathogen in 8% (17/199) of diarrhoeic stool specimens. Other organisms were detected along with rotavirus in 11% of faecal specimens. A third of the children with rotavirus diarrhoea, according to Vesikari score, had severe illness. The top four rotavirus genotypes were G9P[4] (28%), G1P[8] (19%), G2P[4] (14%) and G8P[4] (8%). In the multivariate model, the practice of 'drawing drinking water by dipping a pot in the storage vessel' [adjusted odds ratio (aOR) 2·21, 95% confidence interval (CI) 1·03-4·74, P = 0·041], and 'children aged ⩽6 months with non-exclusive breastfeeding' (aOR 2·07, 95% CI 1·1-3·82, P = 0·024) had twice the odds of having diarrhoea. Incidence of rotavirus diarrhoea was 24/100 child-years in children aged >6-18 months, 19/100 child-years in children aged >18-24 months and 5/100 child-years in those aged ⩽6 months. Results have translational implications for future interventions including vaccine development.
National Institute of Cholera & Enteric Diseases/ICMR,Kolkata,India.
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S
Panda
National Institute of Cholera & Enteric Diseases/ICMR,Kolkata,India.
A K
AK
Deb
National Institute of Cholera & Enteric Diseases/ICMR,Kolkata,India.
M
M
Chawla-Sarkar
National Institute of Cholera & Enteric Diseases/ICMR,Kolkata,India.
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T
Ramamurthy
National Institute of Cholera & Enteric Diseases/ICMR,Kolkata,India.
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S
Ganguly
National Institute of Cholera & Enteric Diseases/ICMR,Kolkata,India.
P
P
Pradhan
National Institute of Cholera & Enteric Diseases/ICMR,Kolkata,India.
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Chakraborty
Serum Institute of India Limited,Pune,India.
S
S
Desai
Serum Institute of India Limited,Pune,India.
M D
MD
Gupte
Serum Institute of India Limited,Pune,India.
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Dhere
D003967:Diarrhea / Q000453:epidemiology*; D005243:Feces / Q000821:virology; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D012401:Rotavirus / Q000235:genetics / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology*; D012424:Rural Population