Ubiquitin carboxyl hydrolase L1 significance for human diseases.
Ubiquitin carboxyl hydrolase L1 (UCH-L1) is an abundant multifunctional neuron protein. It plays an important role in maintaining the ubiquitin proteasome system (UPS), vital for recognizing and degrading dysfunctional proteins in organisms. In recent decades, UCH-L1 has been implicated in the pathogenesis of many diseases, including neurodegenerative disorders, cancer and diabetes. However, the mechanisms of UCH-L1 involvement have yet to be revealed in detail. Since UCH-L1 contributes many different functions to cell metabolism, its role and regulation might be more complex than previously thought and it has become a research target in many laboratories. In this review, we summarize recent findings related to the actions of UCH-L1 in several human diseases.
Dang Ngoc Anh
DN
Suong
Dang Thi Phuong
DT
Thao
Yamaguchi
Y
Masamitsu
Department of Molecular and Environmental Biotechnology, University of Science, Vietnam National University in Ho Chi Minh City, Vietnam; Department of Applied Biology, Insect Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. thaodp@hcmus.edu.vn.
Tran Linh
TL
Thuoc
D015415:Biomarkers; D003920:Diabetes Mellitus / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase
D015415:Biomarkers; C482860:UCHL1 protein, human; D043222:Ubiquitin Thiolesterase