MiR-421, miR-155 and miR-650: emerging trends of regulation of cancer and apoptosis.
It is becoming progressively more understandable that between transcription and translation there lies another versatile regulator that quantitatively controls the expression of mRNAs. Identification of miRNAs as key regulators of wide ranging signaling cascades and modulators of different cell-type and context dependent activities attracted basic and clinical scientists to study modes and mechanisms in details. In line with this approach overwhelmingly increasing in vivo and in vitro studies are deepening our understanding regarding miR-421, mir-155 and miR-650 mediated regulation of cellular activities. We also attempt to provide an overview of long non coding RNAs.
Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore, Pakistan E-mail : Ammadahmad638@yahoo.com ilhanyaylim@gmail.com.
Ammad Ahmad
AA
Farooqi
Muhammad Zahid
MZ
Qureshi
Ender
E
Coskunpinar
Syed Kamran-Ul-Hassan
SK
Naqvi
Ilhan
I
Yaylim
Muhammad
M
Ismail
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics
D035683:MicroRNAs; D062085:RNA, Long Noncoding