New chlamydosporol derivatives from the endophytic fungus Fusarium sp. #001.
Two new chlamydosporol derivatives, fusarilactone A (1) and fusarilactone B (2), together with nine known compounds (3-11), have been isolated from the crude extract of endophytic fungus Fusarium sp. #001. The structures of new compounds 1 and 2 were elucidated on the basis of extensive spectroscopic methods. Compound 1 showed mild cytotoxicities against three tumor cell lines (SMMC-7721, A-549, and MCF-7).
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
Zi-Ming
ZM
Chen
Wen-Bin
WB
Dong
Zheng-Hui
ZH
Li
Tao
T
Feng
Ji-Kai
JK
Liu
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005670:Fusarium / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D011753:Pyrones; C000589360:fusarilactone A; C000589361:fusarilactone B; C065449:chlamydosporal
Eupatorium adenophorum; Fusarium sp; chlamydosporol derivatives; cytotoxicity; endophytic fungi