Bone marrow fat.
Bone marrow fat (BMF) results from an accumulation of fat cells within the bone marrow. Fat is not a simple filling tissue but is now considered as an actor within bone microenvironment. BMF is not comparable to other fat depots, as in subcutaneous or visceral tissues. Recent studies on bone marrow adipocytes have shown that they do not appear only as storage cells, but also as cells secreting adipokines, like leptin and adiponectin. Moreover bone marrow adipocytes share the same precursor with osteoblasts, the mesenchymal stem cell. It is now well established that high BMF is associated with weak bone mass in osteoporosis, especially during aging and anorexia nervosa. But numerous questions remain discussed: what is the precise phenotype of bone marrow adipocytes? What is the real function of BMF, and how does bone marrow adipocyte act on its environment? Is the increase of BMF during osteoporosis responsible for bone loss? Is BMF involved in other diseases? How to measure BMF in humans? A better understanding of BMF could allow to obtain new diagnostic tools for osteoporosis management, and could open major therapeutic perspectives.
Université Lille Nord-de-France, 59000 Lille, France; Université du Littoral Côte-d'Opale PMOI, boulevard Napoléon, BP 120, 62327 Boulogne-sur-Mer, France; PMOI EA 4490, 62327 Boulogne-sur-Mer, France. Electronic address: pierre.hardouin@univ-littoral.fr.
Pierre
P
Hardouin
Université Lille Nord-de-France, 59000 Lille, France; PMOI EA 4490, 59000 Lille, France; Université droit et santé Lille 2, 59000 Lille, France; Service d'imagerie musculo-squeletique, CHRU, 59000 Lille, France.
Vittorio
V
Pansini
Université Lille Nord-de-France, 59000 Lille, France; PMOI EA 4490, 59000 Lille, France; Université droit et santé Lille 2, 59000 Lille, France; Service de rhumatologie, CHRU, 59000 Lille, France.
Bernard
B
Cortet
D017667:Adipocytes / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism*; D006801:Humans; D010024:Osteoporosis / Q000378:metabolism*
Adipocyte; Anorexia nervosa; Bone marrow; Fat; Osteoblast; Osteoporosis