The effects of stent interaction on porcine urinary bladder matrix employed as stent-graft materials.
Deployment of stent-grafts, derived from synthetic biomaterials, is an established minimally invasive approach for effectively treating abdominal aortic aneurysms (AAAs). However, a notable disadvantage associated with this surgical technique is migration of the deployed stent-graft due to poor biocompatibility and inadequate integration in vivo. Recently, tissue-engineered extracellular matrices (ECMs) have shown early promise as integrating stabilisation collars in this setting due to their ability to induce a constructive tissue remodelling response after in vivo implantation. In the present study the effects of stent loading on an ECM׳s mechanical properties were investigated by characterising the compression and loading effects of endovascular stents on porcine urinary bladder matrix (UBM) scaffolds. Results demonstrated that the maximum stress was induced when the stent force was 8-times higher than a standard commercially available stent-graft and this represented about 20% of the failure strength of the UBM material. In addition, the influence of stent shape was also investigated. Findings demonstrated that the stress induced was higher for circular stents at low forces and a higher stress was induced on square stents when increased force was applied. Our findings demonstrate that porcine UBM possesses sufficient mechanical strength to withstand the compression and loading effects of commercially available stent-grafts in the setting of endovascular aneurysm repair.
Institute for Bioengineering, School of Engineering, The University of Edinburgh, Edinburgh EH9 3JL, UK; Centre for Applied Biomedical Engineering Research, Department of Mechanical, Aeronautical and Biomedical Engineering and the Materials and Surface Science Institute, University of Limerick, Ireland. Electronic address: anthony.callanan@ed.ac.uk.
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Callanan
Centre for Applied Biomedical Engineering Research, Department of Mechanical, Aeronautical and Biomedical Engineering and the Materials and Surface Science Institute, University of Limerick, Ireland.
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Davis
Centre for Applied Biomedical Engineering Research, Department of Mechanical, Aeronautical and Biomedical Engineering and the Materials and Surface Science Institute, University of Limerick, Ireland; Department of Biomedical Engineering, Khalifa University of Science, Technology & Research (KUSTAR), P.O. Box: 127788, Abu Dhabi, UAE.
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McGloughlin
Centre for Applied Biomedical Engineering Research, Department of Mechanical, Aeronautical and Biomedical Engineering and the Materials and Surface Science Institute, University of Limerick, Ireland.
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Walsh
D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology* / Q000601:surgery*; D001672:Biocompatible Materials / Q000737:chemistry; D001696:Biomechanical Phenomena; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D008422:Materials Testing; D016062:Porosity; D015607:Stents; D013314:Stress, Mechanical; D013552:Swine; D013718:Tensile Strength; D023822:Tissue Engineering / Q000379:methods*; D001743:Urinary Bladder / Q000502:physiology* / Q000503:physiopathology
D001672:Biocompatible Materials
Abdominal aortic aneurysm; Bioengineering; Biomechanics; Stress analysis; Tissue engineering