Factors associated with the quality of life of subjects with Parkinson's disease and burden on their caregivers.
BACKGROUND
Parkinson's disease affects the quality of life of the individual with the disease in addition to creating a burden on the caregiver. Factors related to these effects include motor and non-motor aspects of the disease, as well as traits inherent to the caregiver.


METHODS
We evaluated subjects with Parkinson's disease using the following instruments: Quality of Life Questionnaire PDQ-8, Movement Disorders Society Unified Parkinson's disease Rating Scale part i to iv (MDS-UPDRS), and Hoehn and Yahr staging. The Zarit Burden Inventory was used to assess all primary caregivers. Major demographic and clinical variables were also recorded.


RESULTS
A total of 250 subjects with Parkinson's disease were included, of whom 201 had a primary caregiver. In the multivariate analysis, predictors of poor quality of life for a subject with Parkinson's disease were the MDS-UPDRS I score (β=.39, P<.001), MDS-UPDRS II score (β=.21, P<.001), and MDS-UPDRS III score (β=.07, P=.004). Regarding caregiver burden, the MDS-UPDRS II score (β=.54, P=.007) was the most influential factor.


CONCLUSIONS
The present study shows a relationship between quality of life for the subject with Parkinson's disease and the caregiver's perceived burden. However, the factors that determine each situation appear to be distinct.
Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, México D.F., México; Neurología Clínica de Trastornos del Movimiento, Instituto Nacional de Neurología y Neurocirugía, México D.F., México. Electronic address: mrodriguez@innn.edu.mx.
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Rodríguez-Violante
Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, México D.F., México.
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Camacho-Ordoñez
Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, México D.F., México.
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Cervantes-Arriaga
Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, México D.F., México.
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González-Latapí
Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, México D.F., México; Neurología Clínica de Trastornos del Movimiento, Instituto Nacional de Neurología y Neurocirugía, México D.F., México.
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Velázquez-Osuna
D000328:Adult; D000368:Aged; D017028:Caregivers / Q000523:psychology; D017281:Cost of Illness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
Calidad de vida; Caregiver burden; Carga en el cuidador; Cuidador primario; Enfermedad de Parkinson; Motor symptoms; Non-motor symptoms; Parkinson's disease; Primary caregiver; Quality of life; Síntomas motores; Síntomas no motores