Silencing SATB1 influences cell invasion, migration, proliferation, and drug resistance in nasopharyngeal carcinoma.
Special AT rich sequence binding protein 1 (SATB1) play an important role in many cancers, but the role of SATB1 in nasopharyngeal carcinoma (NPC) is still not full understand. Immunofluorescence staining showed that SATB1 was mainly localized in the nuclei in CNE-2 cell. After successful down-regulation of SABT1 in NPC cell line CNE-2 by shRNA, compared to parental CNE-2 and control shRNA group, the capacity of the proliferation, migration, invasion and drug resistance of CNE-2 cell was reduced, which indicated that SATB1 may be involved in NPC development and progression. SATB1 may be a promising therapeutic target for nasopharyngeal carcinoma.
Department of Otolaryngology-Head and Neck Surgery, Zhongshan Hospital, Xiamen University Xiamen, China.
Chun-Sheng
CS
Ye
Department of Pathology, Zhongshan Hospital, Xiamen University Xiamen, China.
Dong-Ni
DN
Zhou
Department of Otolaryngology-Head and Neck Surgery, Union School of Clinical Medicine, Fujian Medical University Fuzhou, China.
Qing-Qing
QQ
Yang
Department of Otolaryngology-Head and Neck Surgery, Zhongshan Hospital, Xiamen University Xiamen, China ; Department of Otolaryngology-Head and Neck Surgery, Union School of Clinical Medicine, Fujian Medical University Fuzhou, China.
Yan-Fei
YF
Deng
D015153:Blotting, Western; D002277:Carcinoma; D045744:Cell Line, Tumor; D002465:Cell Movement; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005455:Fluorescent Antibody Technique; D020868:Gene Silencing; D006801:Humans; D036961:Matrix Attachment Region Binding Proteins / Q000096:biosynthesis / Q000235:genetics*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014162:Transfection
D036961:Matrix Attachment Region Binding Proteins; C076189:SATB1 protein, human
Nasopharyngeal carcinoma; SATB1; drug resistance; invasion; proliferation