The contemporary role of ablative treatment approaches in the management of renal cell carcinoma (RCC): focus on radiofrequency ablation (RFA), high-intensity focused ultrasound (HIFU), and cryoablation.
BACKGROUND
Currently, most of renal tumors are small, low grade, with a slow growth rate, a low metastatic potential, and with up to 30 % of these tumors being benign on the final pathology. Moreover, they are often diagnosed in elderly patients with preexisting medical comorbidities in whom the underlying medical conditions may pose a greater risk of death than the small renal mass. Concerns regarding overdiagnosis and overtreatment of patients with indolent small renal tumors have led to an increasing interest in minimally invasive, ablative as an alternative to extirpative interventions for selected patients.


OBJECTIVE
To provide an overview about the state of the art in radiofrequency ablation (RFA), high-intensity focused ultrasound, and cryoablation in the clinical management of renal cell carcinoma.


METHODS
A PubMed wide the literature search of was conducted.


RESULTS
International consensus panels recommend ablative techniques in patients who are unfit for surgery, who are not considered candidates for or elect against elective surveillance, and who have small renal masses. The most often used techniques are cryoablation and RFA. These ablative techniques offer potentially curative outcomes while conferring several advantages over extirpative surgery, including improved patient procedural tolerance, faster recovery, preservation of renal function, and reduction in the risk of intraoperative and postsurgical complications. While it is likely that outcomes associated with ablative modalities will improve with further advances in technology, their application will expand to more elective indications as longer-term efficacy data become available.


CONCLUSIONS
Ablative techniques pose a valid treatment option in selected patients.
Department of Urology, Medical University of Vienna, Vienna, Austria.
Tobias
T
Klatte
Nils
N
Kroeger
Uwe
U
Zimmermann
Martin
M
Burchardt
Arie S
AS
Belldegrun
Allan J
AJ
Pantuck
D002292:Carcinoma, Renal Cell / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D003452:Cryosurgery / Q000379:methods*; D019468:Disease Management; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D007680:Kidney Neoplasms / Q000601:surgery*