A case of oxaliplatin-induced immune-mediated thrombocytopenia.
Oxaliplatin is a platinum compound used in patients with gastrointestinal malignancies. It is known to evoke a drug-induced immune-mediated thrombocytopenia, which has not been reported in Korea. We describe a 53-year-old man who developed oxaliplatin-induced immune-mediated thrombocytopenia during chemotherapy for colon cancer. Oxaliplatin-dependent IgG platelet antibodies were detected in his serum on flow cytometry. He was treated with immunoglobulin and corticosteroids without any complications. Physicians should consider oxaliplatin-induced immune-mediated thrombocytopenia, when a sudden, isolated thrombocytopenia develops during chemotherapy with oxaliplatin.
Department of Internal Medicine, School of Medicine, CHA University, Seongnam, Korea.
Seong Eun
SE
Suh
Department of Internal Medicine, School of Medicine, CHA University, Seongnam, Korea.
Moon Ju
MJ
Jang
Department of Internal Medicine, School of Medicine, CHA University, Seongnam, Korea.
So Young
SY
Chong
Platelet & Neutrophil Immunology Laboratory, Blood Center of Wisconsin, Milwaukee, WI, USA.
Richard H
RH
Aster
Platelet & Neutrophil Immunology Laboratory, Blood Center of Wisconsin, Milwaukee, WI, USA.
Brian R
BR
Curtis
Department of Internal Medicine, School of Medicine, CHA University, Seongnam, Korea.
Doyeun
D
Oh
Drug-dependent platelet antibody; Immune; Oxaliplatin; Thrombocytopenia