A host MicroRNA brokers truce with HSV-1.
Establishing lifelong infection and periodically shedding infectious progeny is a successful strategy employed by several persistent pathogens. In this issue of Cell Host & Microbe, Pan et al. (2014) demonstrate that a cell-type-specific host microRNA can restrict gene expression and pathogenicity of herpes simplex virus 1, thereby promoting long-term infection.
The University of Texas at Austin, Molecular Biosciences, 1 University Station A5000, Austin TX 78712-0162, USA.
Justin M
JM
Pare
The University of Texas at Austin, Molecular Biosciences, 1 University Station A5000, Austin TX 78712-0162, USA. Electronic address: chris_sullivan@austin.utexas.edu.
Christopher S
CS
Sullivan
D000818:Animals; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006801:Humans; D017874:Immediate-Early Proteins / Q000096:biosynthesis* / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D012668:Trigeminal Ganglion / Q000821:virology*; D044767:Ubiquitin-Protein Ligases / Q000096:biosynthesis* / Q000235:genetics*
D017874:Immediate-Early Proteins; C546110:MIRN138 microRNA, human; D035683:MicroRNAs; D044767:Ubiquitin-Protein Ligases; C051804:Vmw110 protein, Human herpesvirus 1