Vitamin D replacement therapy in patients with cardiac syndrome X.
OBJECTIVE
The aim of present study was to assess whether vitamin D, with proven beneficial effects on the cardiovascular system, has any effect on angina and exercise-induced ischemia in patients with cardiac syndrome X and low serum vitamin D.


METHODS
Patients with cardiac syndrome X and low serum vitamin D3 were studied before and after treatment with an intramuscular injection of vitamin D3 (300,000 units, every other week for 2 months). We determined the angina episode (per day) and several indices of exercise capacity.


RESULTS
At the end of the treatment course (75±6 day), a significant increase of serum vitamin D3 occurred and was within the normal range (45±8 ng/ml) and the frequency of angina improved significantly (p=0.003). Exercise duration and maximal work capacity increased significantly (p<0.001). Maximal ST-segment depression (mm) decreased significantly (p=0.001). The calculated Duck treadmill score improved significantly (p=0.001).


CONCLUSIONS
Our findings show that vitamin D replacement therapy in patients with cardiac syndrome X and vitamin D deficiency dramatically improves symptoms and signs of ischemia.
Cardiovascular Research Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
A
A
Andishmand
Cardiovascular Research Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Z
Z
Ansari
Cardiovascular Research Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
M H
MH
Soltani
Cardiovascular Research Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran mirshamsih@yahoo.com.
H
H
Mirshamsi
Cardiovascular Research Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
S
S
Raafat
D005080:Exercise Test; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007511:Ischemia / Q000097:blood / Q000517:prevention & control*; D008297:Male; D017566:Microvascular Angina / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D011379:Prognosis; D014807:Vitamin D / Q000008:administration & dosage*; D014808:Vitamin D Deficiency / Q000150:complications / Q000503:physiopathology*
D014807:Vitamin D
cardiac syndrome X; ischemia; replacement therapy; vitamin D; vitamin D deficiency