Preparation and characterization of in-situ crosslinked pectin-gelatin hydrogels.
Crosslinked hydrogels were developed by in-situ reaction of periodate oxidized pectin (OP) and gelatin. The reaction takes place through the formation of Schiff bases between aldehyde groups of OP and amino groups of gelatin. The effect of various process parameters such as reaction time, reaction temperature, pH of the reaction and composition on the efficacy of the crosslinking was investigated. Field emission scanning electron micrsocopy (FESEM) revealed that homogenous, single phase systems are obtained after the crosslinking of OP and gelatin. The swelling characteristics of the hydrogels were monitored. The equilibrium swelling varies in the range of 195-324% with a variation in the gelatin content (10-40%). Glycerol, when used as a plasticizer, improved the flexibility and the handling characteristics of the crosslinked hydrogels. Plasticized films retained good tensile strengths in the range of 19-48 MPa. By proper selection of the reaction conditions, the efficiency of crosslinking can be controlled to obtain the optimum results.
Bioengineering Lab, Department of Textile Technology, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India. Electronic address: bgupta@textile.iitd.ernet.in.
Bhuvanesh
B
Gupta
Bioengineering Lab, Department of Textile Technology, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India.
Mythili
M
Tummalapalli
Bioengineering Lab, Department of Textile Technology, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India.
B L
BL
Deopura
Department of Chemistry, Jamia Hamdard, New Delhi 110062, India.
M S
MS
Alam
D001672:Biocompatible Materials / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry*; D005990:Glycerol / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning / Q000379:methods; D010084:Oxidation-Reduction; D010368:Pectins / Q000737:chemistry*; D010504:Periodic Acid / Q000737:chemistry; D010968:Plasticizers / Q000737:chemistry; D018583:Pliability; D012545:Schiff Bases / Q000138:chemical synthesis; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013718:Tensile Strength; D014783:Viscosity
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D020100:Hydrogels; D010968:Plasticizers; D012545:Schiff Bases; D010504:Periodic Acid; D010368:Pectins; D005780:Gelatin; D005990:Glycerol
Crosslinking; Gelatin; Glycerol; Hydrogel; Oxidized pectin; Schiff base