An epigenetic way to forget those painful moments.
Traumatic experience can be overwhelming, thus erasing associated memories is desirable. Although exposure-based and reconsolidation methods have been developed for recently acquired associations, treatments to modify more distant memories are rare. Focusing on HDAC2 inhibition during reconsolidation, Gräff and colleagues recently demonstrated an epigenetic means to attenuate remote fear memory.
Department of Biology, Institute of Zoology, Chemin du Musée 10, CH-1700 Fribourg, Switzerland.
Sören
S
Diegelmann
Department of Biology, Institute of Zoology, Chemin du Musée 10, CH-1700 Fribourg, Switzerland. Electronic address: simon.sprecher@unifr.ch.
Simon G
SG
Sprecher
D000818:Animals; D001921:Brain / Q000502:physiology; D044127:Epigenesis, Genetic; D051548:Histone Acetyltransferases / Q000235:genetics; D056464:Histone Deacetylase 2 / Q000235:genetics; D006801:Humans; D008568:Memory / Q000502:physiology*; D009473:Neuronal Plasticity / Q000235:genetics
D051548:Histone Acetyltransferases; C533423:HDAC2 protein, human; D056464:Histone Deacetylase 2