New formulation of functionalized bioactive glasses to be used as carriers for the development of pH-stimuli responsive biomaterials for bone diseases.
The aim of the present contribution is to prepare a functionalized bioactive glass potentially useful as prosthetic material, but also able to release organic molecules in response to a change of the pH environment. By this approach it is possible to develop devices which can be used for a triggered drug release in response to specific stimuli; this is an attractive research field, in order to avoid either systemic and/or local toxic effects of drugs. In particular, in the present paper we report data related to the development of a new formulation of bioactive glasses, their functionalization with organic molecules to obtain a pH-sensitive bond, their physicochemical characterization and in vitro bioactivity in simulated biological fluids (SBF), and organic molecule delivery tests at different pH. The glass functionalization, by means of a covalent reaction, allows us to produce a model of pH-responsive bioactive biomaterial: when it is exposed to specific pH changes, it can favor the release of the organic molecules directly at the target site. Cysteamine and 5-aminofluorescein are used as model molecules to simulate a drug. The materials, before and after the different functionalization steps and in vitro release tests at different pH, have been characterized by means of different experimental techniques such as X-ray powder diffraction (XRPD), Raman, FTIR and fluorescence spectroscopies, N2 adsorption, thermogravimetric (TGA) and elemental analysis.
Department of Chemistry, Interdepartmental Centre Nanostructured Interfaces and Surfaces - NIS; INSTM (Italian National Consortium for Materials Science and Technology), University of Torino , Via P. Giuria 7, 10125 Torino, Italy.
Valentina
V
Aina
Claudio
C
Magistris
Giuseppina
G
Cerrato
Gianmario
G
Martra
Guido
G
Viscardi
Gigliola
G
Lusvardi
Gianluca
G
Malavasi
Ledi
L
Menabue
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001847:Bone Diseases / Q000188:drug therapy; D003543:Cysteamine / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005452:Fluoresceins / Q000737:chemistry; D005898:Glass / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration
D001672:Biocompatible Materials; D005452:Fluoresceins; C030864:5-aminofluorescein; D003543:Cysteamine