Meta-analysis of protocolized goal-directed hemodynamic optimization for the management of severe sepsis and septic shock in the Emergency Department.
BACKGROUND
To perform a meta-analysis identifying studies instituting protocolized hemodynamic optimization in the emergency department (ED) for patients with severe sepsis and septic shock.


METHODS
We modeled the structure of this analysis after the QUORUM and MOOSE published recommendations for scientific reviews. A computer search to identify articles was performed from 1980 to present. Studies included for analysis were adult controlled trials implementing protocolized hemodynamic optimization in the ED for patients with severe sepsis and septic shock. Primary outcome data was extracted and analyzed by 2 reviewers with the primary endpoint being short-term mortality reported either as 28-day or in-hospital mortality.


RESULTS
We identified 1,323 articles with 65 retrieved for review. After application of inclusion and exclusion criteria 25 studies (15 manuscripts, 10 abstracts) were included for analysis (n=9597). The mortality rate for patients receiving protocolized hemodynamic optimization (n=6031) was 25.8% contrasted to 41.6% in control groups (n=3566, p<0.0001).


CONCLUSIONS
Protocolized hemodynamic optimization in the ED for patients with severe sepsis and septic shock appears to reduce mortality.
Yale University, Department of Emergency Medicine, New Haven, Connecticut.
Charles R
CR
Wira
Yale University, Department of Emergency Medicine, New Haven, Connecticut.
Kelly
K
Dodge
Yale University, Department of Emergency Medicine and Surgical Critical Care, New Haven, Connecticut.
John
J
Sather
Yale University, Department of Emergency Medicine, New Haven, Connecticut.
James
J
Dziura
D002985:Clinical Protocols; D004636:Emergency Service, Hospital; D006439:Hemodynamics; D006801:Humans; D010347:Patient Care Planning; D018805:Sepsis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D012772:Shock, Septic / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome