Regional differences in recipient waitlist time and pre- and post-transplant mortality after the 2006 United Network for Organ Sharing policy changes in the donor heart allocation algorithm.
OBJECTIVE
This study examined the impact of the United Network for Organ Sharing (UNOS) policy changes for regional differences in waitlist time and mortality before and after heart transplantation.


BACKGROUND
The 2006 UNOS thoracic organ allocation policy change was implemented to allow for greater regional sharing of organs for heart transplantation.


METHODS
We analyzed 36,789 patients who were listed for heart transplantation from January 1999 through April 2012. These patients were separated into 2 eras centered on the July 12, 2006 UNOS policy change. Pre- and post-transplantation characteristics were compared by UNOS regions.


RESULTS
Waitlist mortality decreased nationally (up to 180 days: 13.3% vs. 7.9% after the UNOS policy change, p < 0.001) and within each region. Similarly, 2-year post-transplant mortality decreased nationally (2-year mortality: 17.3% vs. 14.6%; p < 0.001) as well as regionally. Waitlist time for UNOS status 1A and 1B candidates increased nationally 17.8 days on average (p < 0.001) with variability between the regions. The greatest increases were in Region 9 (59.2-day increase, p < 0.001) and Region 4 (41.2-day increase, p < 0.001). Although the use of mechanical circulatory support increased nearly 2.3-fold nationally in Era 2, significant differences were present on a regional basis. In Regions 6, 7, and 10, nearly 40% of those transplanted required left ventricular assist device bridging, whereas only 19.6%, 22.3%, and 15.5% required a left ventricular assist device in regions 3, 4, and 5, respectively.


CONCLUSIONS
The 2006 UNOS policy change has resulted in significant regional heterogeneity with respect to waitlist time and reliance on mechanical circulatory support as a bridge to transplantation, although overall both waitlist mortality and post-transplant survival are improved.
Department of Medicine, Division of Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York. Electronic address: pcs2121@cumc.columbia.edu.
P Christian
PC
Schulze
Department of Medicine, Division of Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York.
Shuichi
S
Kitada
Department of Medicine, Division of Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York.
Kevin
K
Clerkin
Division of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, New York.
Zhezhen
Z
Jin
Department of Medicine, Division of Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York.
Donna M
DM
Mancini
D000465:Algorithms; D005260:Female; D006291:Health Policy; D006333:Heart Failure / Q000601:surgery; D016027:Heart Transplantation / Q000401:mortality*; D006353:Heart-Assist Devices / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000401:mortality; D011300:Preoperative Care / Q000401:mortality; D040841:Resource Allocation; D009927:Tissue and Organ Procurement / Q000458:organization & administration*; D014481:United States / Q000453:epidemiology; D014850:Waiting Lists / Q000401:mortality*
United Network of Organ Sharing; heart transplantation; ventricular assist device