Genetic markers in a multi-ethnic sample for childhood acute lymphoblastic leukemia risk.
Genome-wide association studies have identified multiple risk loci for childhood acute lymphoblastic leukemia (ALL), but mostly in European/White populations, despite Hispanics having a greater risk. We re-examined single nucleotide polymorphisms (SNPs) of known associations with childhood ALL and known human leukocyte antigen (HLA) region lymphoma risk markers in a multi-ethnic population. Significant associations were found in two ARID5B variants (rs7089424 and rs10821936). We replicated a strong risk association in non-Hispanic White males with rs2395185, a protective marker for lymphoma. Another HLA region marker, rs2647012, showed a risk association among Hispanics only, while a strong protective association was found with rs1048456, a follicular lymphoma risk marker. Our study validated this new case-control sample by confirming genetic markers associated with childhood ALL, and yielded new associations with lymphoma markers. Despite positive results, our study did not provide any clues as to why Hispanics have a higher susceptibility to childhood leukemia, suggesting that environmental factors may have a strong contribution.
Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University , Miami, FL , USA.
Amy E
AE
Kennedy
Kala Y
KY
Kamdar
Philip J
PJ
Lupo
M Fatih
MF
Okcu
Michael E
ME
Scheurer
M Tevfik
MT
Dorak
D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
D005819:Genetic Markers; D006680:HLA Antigens
Genetic associations; childhood acute lymphoblastic leukemia; genetic predisposition to disease