Role of non-acid reflux in patients with non-erosive reflux disease.
Non-erosive reflux disease (NERD) is the most common presentation of gastroesophageal reflux disease. Although acid reflux is the most important cause of symptom generation in NERD patients, non-acid reflux is also associated with reflux symptoms. The temporal relation between symptoms and reflux episodes is of importance in evaluating the results of combined pH-impedance monitoring in NERD patients. Mucosal hypersensitivity and mechanical stimulation due to great volume of non-acid reflux are among the putative mechanisms of symptom generation.
Gastroenterology Unit, 2 Surgical Department, Aretaieion Hospital, Athens Medical School, Athens, Greece (Georgios P. Karamanolis).
Georgios P
GP
Karamanolis
Division of Gastroenterology, University Clinics of Visceral Surgery and Medicine, Bern University Hospital, Inselspital Bern, Bern, Switzerland (Radu Tutuian).
Radu
R
Tutuian
Non-acid reflux; non-erosive reflux disease