[A case of drug-induced hypersensitivity syndrome caused by levofloxacin used for treating pulmonary tuberculosis].
The patient was a 27-year-old man with pulmonary tuberculosis, who was initially treated with isoniazid, rifampicin, ethambutol, and pyrazinamide. However, because of hepatic dysfunction and visual impairment, the four-drug therapy was switched to a three-drug regimen with isoniazid, rifampicin, and levofloxacin. At 9 weeks after the initiation of levofloxacin, the patient developed cervical lymphadenopathy, fever, systemic erythema, and hepatic dysfunction. He was diagnosed with drug-induced hypersensitivity syndrome (DIHS) based on positive results in the human herpesvirus (HHV)-6 DNA test, an indicator of HHV-6 reactivation. The symptoms improved after withdrawal of the antituberculosis drugs and initiation of steroid administration. However, considering the risk of relapse of DIHS, the tuberculosis treatment, which was initially planned for 9 months, was stopped at 7 months. Neither DIHS nor tuberculosis recurred.
Otohiro
O
Katsube
Makiko
M
Anzai
Yushi
Y
Nomura
Naoya
N
Ikeda
Hidenori
H
Takizawa
Yasuko
Y
Kikkawa
Toshio
T
Numao
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology; D006801:Humans; D064704:Levofloxacin / Q000009:adverse effects*; D008297:Male; D013577:Syndrome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D064704:Levofloxacin