Preoperative hepatitis B virus DNA level is a risk factor for postoperative liver failure in patients who underwent partial hepatectomy for hepatitis B-related hepatocellular carcinoma.
OBJECTIVE
Our objective was to explore the short-term effects of preoperative serum hepatitis B virus DNA level (HBV DNA) on postoperative hepatic function in patients who underwent partial hepatectomy for hepatitis B-related hepatocellular carcinoma (HCC).


METHODS
The clinical data of 1,602 patients with hepatitis B-related HCC who underwent partial hepatectomy in our department were retrospectively studied. The patients were divided into three groups according to their preoperative HBV DNA levels: group A <200 IU/mL, group B 200-20,000 IU/mL, and group C >20,000 IU/mL. The rates of postoperative complications, especially the rate of postoperative liver failure, were compared.


RESULTS
There were significant differences among the three groups in the rates of postoperative liver failure. On multivariate logistic regression analysis, a high preoperative HBV DNA level was an independent risk factor for postoperative liver failure.


CONCLUSIONS
Preoperative HBV DNA level was a significant risk factor for postoperative hepatic dysfunction.
The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China.
Gang
G
Huang
Wan Yee
WY
Lau
Feng
F
Shen
Ze-Ya
ZY
Pan
Si-Yuan
SY
Fu
Yun
Y
Yang
Wei-Ping
WP
Zhou
Meng-Chao
MC
Wu
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000601:surgery* / Q000821:virology; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects*; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D017093:Liver Failure / Q000209:etiology* / Q000517:prevention & control; D008113:Liver Neoplasms / Q000601:surgery* / Q000821:virology; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D057234:Preoperative Period; D012189:Retrospective Studies; D012307:Risk Factors
D000998:Antiviral Agents; D004279:DNA, Viral