Topical mitomycin C can effectively alleviate dysphagia in children with long-segment caustic esophageal strictures.
Caustic ingestion in children and the resulting long esophageal strictures are usually difficult to be managed, and eventually, esophageal replacement was required for cases refractory to frequent dilatation sessions. Topical mitomycin C (MMC) application has been used recently to improve the results of endoscopic dilatation for short esophageal strictures. The study aims to assess the role of MMC application in management of long-segment caustic esophageal strictures. From January 2009 to June December 2013, patients presented with long caustic esophageal stricture (>3 cm in length) were included in this study and subjected to topical MMC application after endoscopic esophageal dilatation on multiple sessions. Regular follow-up and re-evaluation were done. A dysphagia score was used for close follow-up clinically; verification was done radiologically and endoscopically. During the specified follow-up period, 21 patients with long caustic esophageal stricture were subjected to topical MMC application sessions. Clinical, radiological, and endoscopic resolution of strictures occurred in 18 patients (85.7% cure rate). Number of dilatation sessions to achieve resolution of dysphagia was (n = 14.3 ± 5.7) with application of mitomycin two to six times. There was no recurrence in short- and mid-term follow-up. No complications were encountered related to topical MMC application. MMC is a promising agent in management of long-segment caustic esophageal strictures. Long-term follow-up is needed to prove its efficacy and to evaluate potential long-term side-effects of MMC application.
Department of Pediatric Surgery, Ain Shams University, Cairo, Egypt.
K M
KM
El-Asmar
Department of Otolaryngology, Ain Shams University, Cairo, Egypt.
M A
MA
Hassan
Department of Pediatric Surgery, Ain Shams University, Cairo, Egypt.
H M
HM
Abdelkader
Department of Pediatric Surgery, Ain Shams University, Cairo, Egypt.
A F
AF
Hamza
D000287:Administration, Topical; D000477:Alkylating Agents / Q000008:administration & dosage*; D002057:Burns, Chemical / Q000150:complications*; D002424:Caustics / Q000633:toxicity; D002675:Child, Preschool; D003680:Deglutition Disorders / Q000188:drug therapy* / Q000209:etiology; D004106:Dilatation; D004311:Double-Blind Method; D004940:Esophageal Stenosis / Q000139:chemically induced / Q000150:complications* / Q000628:therapy; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D016896:Treatment Outcome
D000477:Alkylating Agents; D002424:Caustics; D016685:Mitomycin
caustic esophageal stricture; endoscopic dilatation; long strictures; mitomycin C