Porphyria cutanea tarda in a child following multi-agent chemotherapy.
Porphyria cutanea tarda (PCT) is a blistering skin disorder that occurs most commonly in middle-aged individuals. It is caused by decreased uroporphyrinogen decarboxylase (UROD) activity, which results in elevated levels of uroporphyrinogen. Occurrence remains very rare in children with some sources quoting as few as 50 reports of childhood cases.1 The literature reports occasional cases of PCT onset with various drugs, including barbiturates, estrogens, griseofulvin, rifampicin, sulfonamides, imatinib, methotrexate, tamoxifen, and cyclophosphamide, however its incidence in childhood is uncommon.2-6 We present a case of new-onset PCT in an eight year-old following treatment of pre-B cell acute lymphoblastic leukemia with multi-agent chemotherapy.
Lindsay
L
LaPresto
Hoka
H
Nyanda
Charles F
CF
Knapp
Jennifer
J
Sopkovich
Christopher G
CG
Nelson
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D006983:Hypertrichosis / Q000139:chemically induced; D018962:Phlebotomy; D017119:Porphyria Cutanea Tarda / Q000139:chemically induced* / Q000628:therapy; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy