Obstetric and gynecological diseases and complications resulting from vaginal dysbacteriosis.
Accurate knowledge of the composition and ecology of vaginal microbial environment of a healthy woman is necessary for the understanding of normal flora and how to reduce the risk for diseases. Vagina and its microflora form a balanced ecosystem in which dominated bacteria are vaginal lactobacilli. There are dynamic changes in this ecosystem having structure and composition depending on many factors. The term dysbacteriosis defines any movement outside the normal range for the given biotope of obligate and/or facultative microflora. Such a change in the quantity and quality of the respective microbial balance is fraught with danger and requires correction and recovery. The purpose of this overview is to examine obstetric and gynecological diseases that can cause vaginal impaired microbial balance. Vaginal dysbacteriosis is a cause, predecessor, and often also consequence of vaginal infections. In essence, any vaginal infection can be seen as dysbacteriosis, developed to the most severe extent. Here, there is a dominant microorganism other than lactic acid bacteria in the vagina (clinically manifested or not, respectively), depletion of defense mechanisms of the vagina associated with the shift of lactobacilli from their dominant role in the vaginal balance, decrease in their number and species diversity, and a resulting change in the healthy status of the vagina. Vaginal dysbacteriosis can be found in pathogenetic mechanism, whereby many obstetric and gynecological diseases develop. Most of these diseases lead directly to increased maternal and infant morbidity and mortality, so it is important to understand the reasons for them and the arrangements for their prevention.
Department of Gynecology, Military Medical Academy, "P.U.Todorov" bul. bl. No. 5, entr. B, fl. No. 25, 1404, Sofia, Bulgaria, stkovachev@abv.bg.
Stefan Miladinov
SM
Kovachev
D064806:Dysbiosis; D005260:Female; D005831:Genital Diseases, Female / Q000382:microbiology*; D006801:Humans; D007778:Lactobacillus; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D014621:Vagina / Q000382:microbiology*