Obtaining fast dissolving disintegrating tablets with different doses of melatonin.
Fast dissolving disintegrating tablets (FDDTs) containing different dosages of melatonin have been manufactured for administration to a specific target population: pediatric patients, having potential difficulties taking other oral forms. The lower dosages (3 and 5mg) are intended for epileptic children, migraine prevention, neurodevelopmental disability, sleep disorders and blindness. Dosages of 10 and 60 mg are intended for Duchenne muscular dystrophy. Two FDDT groups have been designed, one which has excipients for direct compression and others having direct compression and effervescent excipients. Tablets have been produced having disintegration times of less than 25s and with friability and hardness values that require no special storage or packaging conditions.
Pharmacy and Pharmaceutical Technology Deparment, School of Pharmacy, University of Granada, Campus de Cartuja s/n., 18071, Granada, Spain.
H
H
Muñoz
Pharmacy and Pharmaceutical Technology Deparment, School of Pharmacy, University of Granada, Campus de Cartuja s/n., 18071, Granada, Spain.
H
H
Castan
Pharmacy and Pharmaceutical Technology Deparment, School of Pharmacy, University of Granada, Campus de Cartuja s/n., 18071, Granada, Spain.
B
B
Clares
Pharmacy and Pharmaceutical Technology Deparment, School of Pharmacy, University of Granada, Campus de Cartuja s/n., 18071, Granada, Spain. Electronic address: adolfina@ugr.es.
M A
MA
Ruiz
D002626:Chemistry, Pharmaceutical; D005079:Excipients / Q000737:chemistry; D006244:Hardness; D006245:Hardness Tests; D007700:Kinetics; D008550:Melatonin / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
D005079:Excipients; D013607:Tablets; D008550:Melatonin
Disintegration times; Dysphagia; FDDTs; Friability; Melatonin; Polyvinylpyrrolidone