Association of alcohol use biomarkers and cognitive performance in veterans with problematic alcohol use and posttraumatic stress disorder: data from the mind your heart study.
The authors conducted a study of alcohol use biomarkers and cognitive performance among 85 veterans with problematic alcohol use and posttraumatic stress disorder (PTSD). All analyses were adjusted for demographics, depression, anxiety, and PTSD symptoms. Elevated levels of aspartate aminotransferase were associated with worse performance on the Trail Making Test Part A and Hopkins Verbal Learning Test. Two other biomarkers were not associated with any neurocognitive measures. Indirect alcohol use biomarkers (e.g., aspartate aminotransferase) may have a specific role in identifying veterans with problematic alcohol use and PTSD who show a change in psychomotor speed and immediate verbal memory performance.
a Department of Psychiatry , University of California , San Francisco , California , USA.
Raj K
RK
Kalapatapu
Thomas C
TC
Neylan
Mathilda C
MC
Regan
Beth E
BE
Cohen
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D019973:Alcohol-Related Disorders / Q000097:blood* / Q000150:complications; D001219:Aspartate Aminotransferases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003071:Cognition / Q000502:physiology*; D004909:Erythrocyte Indices / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013313:Stress Disorders, Post-Traumatic / Q000097:blood* / Q000150:complications; D014728:Veterans / Q000523:psychology
D015415:Biomarkers; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Alcohol use biomarkers; cognitive performance; posttraumatic stress disorder; problematic alcohol use