Replication study of ESCC susceptibility genetic polymorphisms locating in the ADH1B-ADH1C-ADH7 cluster identified by GWAS.
China was one of the countries with highest esophageal squamous cell carcinoma (ESCC) incidence and mortality worldwide. Alcohol drinking has been identified as a major environmental risk-factor related to ESCC. The alcohol dehydrogenase (ADH) family are major enzymes involved in the alcohol-metabolizing pathways, including alcohol dehydrogenase 1B (ADH1B) and ADH1C. Interestingly, ADH1B and ADH1C genes locate tandemly with ADH7 in a genomic segment as a gene cluster, and are all polymorphic. Several ESCC susceptibility single nucleotide polymorphisms (SNPs) of the ADH1B-ADH1C-ADH7 cluster have been identified previously through a genome-wide association study (GWAS). In the study, we examined the association between five ADH1B-ADH1C-ADH7 cluster SNPs (rs1042026, rs17033, rs1614972, rs1789903 and rs17028973) and risk of developing ESCC. Genotypes were determined in two independent case-control sets from two regions of China. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression. Our data demonstrated that these ADH1B-ADH1C-ADH7 cluster SNPs confer susceptibility to ESCC in these two case-control sets, which were consistent to results of the previous GWAS.
Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China; Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang Province, China.
Jiwen
J
Wang
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Jinyu
J
Wei
Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.
Xiaoling
X
Xu
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Wenting
W
Pan
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Yunxia
Y
Ge
Clinical Laboratory, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan, Shandong Province, China.
Changchun
C
Zhou
Clinical Laboratory, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.
Chao
C
Liu
Clinical Laboratory, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jia
J
Gao
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Ming
M
Yang
Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China; Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang Province, China; Thoracic Surgery Department, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.
Weimin
W
Mao
D000368:Aged; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D012307:Risk Factors; D012907:Smoking
C489332:ADH1B protein, human; C420272:ADH1C protein, human; C526911:ADH7 protein, human; D000426:Alcohol Dehydrogenase