IAPs, regulators of innate immunity and inflammation.
As indicated by their name, members of the Inhibitor of APoptosis (IAP) family were first believed to be functionally restricted to apoptosis inhibition. It is now clear that IAPs have a much wider spectrum of action, and recent studies even suggest that some of its members primarily regulate inflammatory responses. Inflammation, the first response of the immune system to infection or tissue injury, is highly regulated by ubiquitylation - a posttranslational modification of proteins with various consequences. In this review, we focus on the recently reported functions of XIAP, cIAP1 and cIAP2 as ubiquitin ligases regulating innate immunity and inflammation.
Inflammation Research Center, VIB, Technologiepark 927, Zwijnaarde-Ghent 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde-Ghent 9052, Belgium.
Yann
Y
Estornes
Inflammation Research Center, VIB, Technologiepark 927, Zwijnaarde-Ghent 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde-Ghent 9052, Belgium. Electronic address: Mathieu.Bertrand@irc.vib-UGent.be.
Mathieu J M
MJ
Bertrand
D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology*; D051034:Inhibitor of Apoptosis Proteins / Q000276:immunology*; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000276:immunology*
D051034:Inhibitor of Apoptosis Proteins; D044767:Ubiquitin-Protein Ligases
IAP; NOD; RIG-I; TLR; TNF