Survival rate of early stage endometrioid adenocarcinoma of endometrium treated at Srinagarind Hospital.
OBJECTIVE
To evaluate the survival outcome of early stage endometrioid adenocarcinoma of the endometrium with risk factors for locoregional recurrence treated with combined pelvic external beam radiotherapy (EBRT) and vaginal brachytherapy (VBT) after comprehensive surgery.


METHODS
Post-operative radiotherapy by pelvic EBRT and VBT for early stage endometrioid endometrial carcinoma resulted in excellent pelvic control with acceptable complications. This study showed no significant relationships between age, stage, histologic grade and LVSI and overall survival rate.


RESULTS
The 5-year overall survival rate (OS) of early stage endometrioid type of endometrial carcinoma was 85.7%. Acute toxicity occurred in 38.1% of the patients, all of whom were grade 1 or 2. Total late toxicity developed in 42.9% of study group, in which 36.99% of them were grade 1-2 and 4.76% were grade 3-4.


CONCLUSIONS
Post-operative radiotherapy by pelvic EBRT and VBT is acceptable for early stage endometrioid endometrial carcinoma, independent of age, stage, histologic grade and LVSI.
Division of Radiotherapy, Department of Radiology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand E-mail : pmonti@kku.ac.th.
Srichai
S
Krusun
Montien
M
Pesee
Withee
W
Rasio
Vorachai
V
Tangvoraphonkchai
Chunsri
C
Supaadirek
Komsan
K
Thamronganantasakul
Narudom
N
Supakalin
Prawat
P
Padoongcharoen
D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods; D018269:Carcinoma, Endometrioid / Q000401:mortality* / Q000473:pathology*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006761:Hospitals; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology; D011184:Postoperative Period; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000379:methods; D012307:Risk Factors; D015996:Survival Rate