[Epigenetic mechanisms in physiologic and pathologic pregnancies].
Epigenetic factors are nowadays in the focus of scientific interest in medicine including obstetrics. The environment in utero and early neonatal life may induce a permanent response in the fetus and the newborn leading to enhanced susceptibility to later diseases. There is now growing evidence that the effects of developmental programming may also manifest themselves in the next generations without further suboptimal exposure. The so-called fetal programming may also highlight a tight connection between pathological conditions in pregnancy, environmental factors and the development of chronic diseases in adulthood. Investigation of epigenetic factors may yield new possibilities for the prevention of chronic diseases affecting a significant part of the population.
Semmelweis Egyetem, Általános Orvostudományi Kar I. Szülészeti és Nőgyógyászati Klinika Budapest Baross utca 27. 1088.
József Gábor
JG
Joó
Biotest Hungaria Kft. Budapest.
Csaba
C
Karabélyos
Semmelweis Egyetem, Általános Orvostudományi Kar I. Szülészeti és Nőgyógyászati Klinika Budapest Baross utca 27. 1088.
Hajnalka
H
Héjja
Egyesített Szent István és Szent László Kórház Budapest.
László
L
Kornya
Semmelweis Egyetem, Általános Orvostudományi Kar I. Szülészeti és Nőgyógyászati Klinika Budapest Baross utca 27. 1088.
János
J
Rigó
D016640:Diabetes, Gestational / Q000235:genetics; D044127:Epigenesis, Genetic; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D010920:Placenta / Q000502:physiology; D010922:Placenta Diseases / Q000235:genetics; D011225:Pre-Eclampsia / Q000235:genetics; D011247:Pregnancy / Q000235:genetics* / Q000502:physiology; D011248:Pregnancy Complications / Q000235:genetics*; D012907:Smoking / Q000235:genetics
DNA-methylation; DNS-metiláció; epigenetics; epigenetika; histon-modifications; hisztonmodifikáció; microRNA; mikro-RNS; pregnancy; terhesség