Meta-analysis of the association between PTPN11 G/A polymorphism at intron 3 with risk of gastric atrophy among East Asians.
OBJECTIVE
Inconsistency of reported associations of the G/A polymorphism (rs2301756) in the PTPN11 gene and gastric atrophy prompted us to undertake a meta-analysis.


METHODS
We searched PubMed for published literature up to July 2013. Individual data from studies with case-control design were evaluated for the PTPN11 G/A polymorphism in Helicobacter pylori (-) (seronegative) and (+) (seropositive) subjects (four studies each, totaling 3,597 cases and 4,865 controls).


RESULTS
Associations of PTPN11 polymorphism with gastric atrophy in H. pylori (-) and (+) subjects are more readily interpreted in the homozygous and recessive models given that the dominant codominant effects skirted null associations. Thus, homozygous and recessive effects indicated reduced risk [odds ratio (OR) 0.92-0.96, p = 0.51-0.74], which is significant among H. pylori (+) subjects (OR 0.66-0.68, p = 0.04-0.05). Confined to the Japanese, reduced risk effects were unaltered in both groups, less protective among seronegative subjects (OR 0.85-0.86, p = 0.71-0.73) than seropositive subjects with significance in the recessive model (OR 0.67, p = 0.05). Sensitivity analysis demonstrated robustness of the seropositive findings, but probably not the seronegative results where homozygous and recessive pooled ORs were altered from protection to increased risk.


CONCLUSIONS
Evidence of overall and subgroup decreased risks, strong in seropositive subjects, demonstrates protective effects of the PTPN11 G/A polymorphism from gastric atrophy.
School of Natural Sciences and Nursing, Saint Louis University, 2600, Baguio City, Philippines.
Noel
N
Pabalan
Neetu
N
Singh
Maria Ruth
MR
Pineda
Hamdi
H
Jarjanazi
D000483:Alleles; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D001284:Atrophy; D001426:Bacterial Proteins / Q000235:genetics; D016022:Case-Control Studies; D005202:Asia, Eastern / Q000453:epidemiology; D005756:Gastritis / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology / Q000473:pathology; D005808:Genes, Recessive; D005838:Genotype; D016481:Helicobacter Infections / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D007438:Introns / Q000235:genetics*; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D011230:Precancerous Conditions / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000235:genetics*; D012306:Risk; D016036:Seroepidemiologic Studies; D013270:Stomach / Q000382:microbiology / Q000473:pathology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori; C516724:PTPN11 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11