Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms.
With the advent of new and improved high-throughput sequencing technologies in the last few years, a growing number of novel classes of small RNA, other than miRNAs or siRNA, has emerged, which appear as new actors in gene expression regulation. tRNA-derived small RNAs represent one of these novel members that are, surprisingly, among the most conserved class of small RNAs throughout evolution. They could represent the most primitive small RNA pathways from which the well-known canonical RNA silencing pathways reported in higher eukaryotes evolved. This review aims to make a compilation of the most relevant research literature in this field with the purpose of shedding light on the relation of these primitive tRNA-derived molecules with the gene silencing machinery.
Laboratory of Functional Genomics, Institute Pasteur of Montevideo, Mataojo 2020, Montevideo 11400, Uruguay. rgarcia@pasteur.edu.uy.
Maria Rosa
MR
Garcia-Silva
Laboratory of Functional Genomics, Institute Pasteur of Montevideo, Mataojo 2020, Montevideo 11400, Uruguay. fcabrera@pasteur.edu.uy.
Florencia
F
Cabrera-Cabrera
Laboratory of Functional Genomics, Institute Pasteur of Montevideo, Mataojo 2020, Montevideo 11400, Uruguay. mcguida@pasteur.edu.uy.
Maria Catalina
MC
Güida
Laboratory of Functional Genomics, Institute Pasteur of Montevideo, Mataojo 2020, Montevideo 11400, Uruguay. cayota@pasteur.edu.uy.
Alfonso
A
Cayota