[Primary selective IgM deficiency--forgotten primary immunodeficiency?].
Immunoglobulin M is a pentamer found in the intravascular compartment and on the surface of B lymphocytes. It is the antibody isotype produced initially in the immune response, and the first immunoglobulin class to be synthesized by a fetus or newborn. IgM antibodies do not cross the placenta. Decreased levels of IgM have been associated with autoimmune disease, several primary immunodeficiency but exist also as selected primary immunodeficiency.
Danuta
D
Kowalczyk
Anna
A
Szaflarska
D001327:Autoimmune Diseases / Q000276:immunology*; D004406:Dysgammaglobulinemia / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000172:deficiency*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*
D007075:Immunoglobulin M