Development of an active site peptide analog of α-fetoprotein that prevents breast cancer.
Epidemiologic studies associate elevated maternal serum levels of α-fetoprotein (AFP) with reduced breast cancer risk for parous women. Laboratory studies demonstrate direct anti-breast cancer activity of AFP. Here, we review the development of a small cyclic peptide that is an active site analog of AFP, referred to as AFPep, which is composed exclusively of amino acids, is orally active, has no discernable toxicity, and is effective for the treatment and prevention of breast cancer in animal models.
Authors' Affiliations: Department of Obstetrics and Gynecology, Center for Cardiovascular Sciences, and Center for Immunology and Microbial Diseases, Albany Medical College, Albany, NYAuthors' Affiliations: Department of Obstetrics and Gynecology, Center for Cardiovascular Sciences, and Center for Immunology and Microbial Diseases, Albany Medical College, Albany, NY.
Herbert I
HI
Jacobson
Authors' Affiliations: Department of Obstetrics and Gynecology, Center for Cardiovascular Sciences, and Center for Immunology and Microbial Diseases, Albany Medical College, Albany, NY anderst@mail.amc.edu.
Thomas T
TT
Andersen
Authors' Affiliations: Department of Obstetrics and Gynecology, Center for Cardiovascular Sciences, and Center for Immunology and Microbial Diseases, Albany Medical College, Albany, NY.
James A
JA
Bennett
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D020134:Catalytic Domain / Q000187:drug effects; D018890:Chemoprevention / Q000379:methods; D055808:Drug Discovery; D005260:Female; D006801:Humans; D010298:Parity / Q000502:physiology; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D011247:Pregnancy; D000509:alpha-Fetoproteins / Q000737:chemistry*
D000970:Antineoplastic Agents; D010446:Peptide Fragments; D000509:alpha-Fetoproteins