Health-related quality of life and productivity losses in patients with depression and anxiety disorders.
OBJECTIVE
To assess the explanatory power of disease severity and health-related quality of life (HRQOL) on absenteeism and presenteeism in a working population suffering from depression and/or anxiety disorders.


METHODS
We used data of a large, multicenter, randomized trial (n = 644). Pearson chi-squared tests, analysis of variance, and multinomial logistic regression analyses were performed to explore associations of the type of the disorder and HRQOL with different types of productivity losses. Multivariate regression analyses were performed to assess associations with the duration of absenteeism.


RESULTS
The type of the disorder, disease severity, and HRQOL were associated with different types of productivity losses. Health-related quality of life and age were significantly associated with the duration of absenteeism.


CONCLUSIONS
Our findings indicate that HRQOL may significantly explain the type of productivity loss as well as the duration of absenteeism.
From the Institute for Medical Technology Assessment (Drs Bouwmans, Vemer, Tan, and Hakkaart-van Roijen), Erasmus University, Rotterdam; and Department of Clinical Psychology (Dr van Straten), VU University Amsterdam, the Netherlands.
C A M
CA
Bouwmans
P
P
Vemer
A
A
van Straten
S S
SS
Tan
L
L
Hakkaart-van Roijen
D000041:Absenteeism; D000328:Adult; D001008:Anxiety Disorders / Q000453:epidemiology*; D003866:Depressive Disorder / Q000453:epidemiology*; D004526:Efficiency; D005260:Female; D006801:Humans; D008297:Male; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires