Correlation research of carotid arterial sclerosis and left ventricular diastolic function in hyperthyroidism.
OBJECTIVE
This study aims to investigate the correlation of carotid arterial sclerosis and left ventricular diastolic function in hyperthyroidism.


METHODS
A total of 70 patients with newly-diagnosed hyperthyroidism, including 32 patients clinically cured or improved after I131 therapy, were compared with 74 healthy cases in the control group. Bilateral carotid ultrasound and echocardiography were performed in all subjects. The carotid sclerosis index B, compliance coefficient CC, pulse wave velocity (PWV) and left ventricular diastolic function parameters (mitral valve diastolic peak velocity ratio E/A, mitral annulus tissue Doppler diastolic peak velocity ratio e/a and E/e) were obtained.


RESULTS
The B, CC, PWV and E/e exhibited correlation. Pre-treatment CC was negatively correlated with E/e (r=-0.325, P<0.01), whereas B and PWV were positively correlated with E/e (r=0.270 and 0.297, P < 0.05). Post-treatment CC was negatively correlated with E/e (r=-0.462, P<0.01), whereas B and PWV were positively correlated with E/e (r=0.513 and 0.479, P<0.01).


CONCLUSIONS
Carotid artery function and left ventricular diastolic function of hyperthyroid patients were damaged before the treatment and recovered after the treatment. Thus, a correlation existed between them. The early detection of carotid artery function could help the early detection of cardiovascular disease in the hyperthyroid patients.
Department of Ultrasound Shanxi Academy of Medical Sciences & Shanxi DAYI Hospital, Taiyuan Shanxi Province, P. R. China - chunsongkangcn@163.com.
J
J
Fang
C
C
Kang
Z
Z
Li
J
J
Xue
H
H
Lv
D000328:Adult; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D016022:Case-Control Studies; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000628:therapy; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D012598:Sclerosis; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D055815:Young Adult
D007457:Iodine Radioisotopes