Role of the lncRNA-p53 regulatory network in cancer.
Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of lncRNAs is often associated with a variety of human diseases including cancer. Of significant interest, recent studies suggest that lncRNAs participate in the p53 tumor suppressor regulatory network. In this review, we discuss how lncRNAs serve as p53 regulators or p53 effectors. Further characterization of these p53-associated lncRNAs in cancer will provide a better understanding of lncRNA-mediated gene regulation in the p53 pathway. As a result, lncRNAs may prove to be valuable biomarkers for cancer diagnosis or potential targets for cancer therapy.
Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ali
A
Zhang
Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Min
M
Xu
Department of Pharmacology/Toxicology and Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA ymo@umc.edu.
Yin-Yuan
YY
Mo
D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D034441:Heterogeneous-Nuclear Ribonucleoproteins; D062085:RNA, Long Noncoding; D016159:Tumor Suppressor Protein p53
gene regulation; lncRNA; oncogenes; p53; tumor suppressor