Bi-directional activation of inflammation and coagulation in septic neonates.
Neonatal sepsis is frequently accompanied by significant and sometimes life-threatening coagulopathy. More complete understanding is needed of the molecular and cellular mechanisms underlying the interaction of the inflammatory and hemostatic systems. Such information may help focus future studies toward novel ways to improve the outcome of neonates who develop septic coagulopathy.
Division of Neonatology, Neonatal Intensive Care Unit, Di Venere Hospital, Bari, Italy. Electronic address: a.delvecchio@asl.bari.it.
Antonio
A
Del Vecchio
Neonatal Intensive Care Unit, Maternal-Infant Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Mauro
M
Stronati
Division of Neonatology, Neonatal Intensive Care Unit, Di Venere Hospital, Bari, Italy.
Caterina
C
Franco
Women and Newborns Program, Intermountain Healthcare, Salt Lake City, Utah, USA.
Robert D
RD
Christensen
D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000097:blood / Q000378:metabolism; D015539:Platelet Activation; D018805:Sepsis / Q000097:blood* / Q000378:metabolism
D016207:Cytokines
Coagulation; Inflammation; Inflammatory cytokines; Neonate; Sepsis