Insulin resistance as early sign of hepatic dysfunction in liver cirrhosis.
Glucose intolerance characterized by postprandial hyperglycemia and hyperinsulinemia is commonly seen in patients with liver cirrhosis (LC). The aim of this study is to clarify the relation between glucose intolerance and disorder of liver function in patients with LC. The 75 g oral glucose tolerance test (75 g OGTT) and the hyperinsulinemic euglycemic clamp combined with 0.2 g/kg oral glucose load (HECGL) were conducted in 61 patients with LC. Based on the results of 75 g OGTT, the 61 patients with LC were divided into groups, 21 (34.4%) patients with normal glucose tolerance (LC-NGT), 12 (19.7%) patients with impaired glucose tolerance (LC-IGT) and 28 (45.9%) patients with diabetes mellitus (LC-DM). Fasting plasma glucose (FPG) level was normal in 50 (82.0%) patients with LC. All patients with LC showed insulin resistance in both peripheral (skeletal and adipose) and hepatic tissues evaluated by HECGL, although significant correlation between the degree of glucose intolerance and the severity of hepatic dysfunction was not observed. Insulin resistance in both liver and peripheral tissues is the early sign in the patients with LC. This fact indicates that nutritional care from early stages of LC would be necessary in the patients.
Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School.
Kayo
K
Taguchi
Hisami
H
Yamanaka-Okumura
Akira
A
Mizuno
Taki
T
Nakamura
Mitsuo
M
Shimada
Toshio
T
Doi
Eiji
E
Takeda
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000378:metabolism / Q000503:physiopathology; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006509:Hepatitis B; D006526:Hepatitis C; D006525:Hepatitis, Viral, Human / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008099:Liver / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000378:metabolism / Q000503:physiopathology*; D008104:Liver Cirrhosis, Alcoholic / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged
D001786:Blood Glucose