Clinical characteristics and oncological outcomes of testicular cancer patients registered in 2005 and 2008: the first large-scale study from the Cancer Registration Committee of the Japanese Urological Association.
OBJECTIVE
To describe the clinical and pathological characteristics and oncological outcomes of testicular cancer diagnosed in Japan, we report the results of the testicular cancer registration carried out by the Japanese Urological Association.


METHODS
Testicular cancer survey was conducted by the Japanese Urological Association in 2011 to register newly diagnosed testicular cancers in 2005 and 2008. The survey included details such as age, presenting symptoms, physical examination findings, tumor markers, histopathology, clinical stage, initial treatment and clinical outcomes.


RESULTS
We analyzed 1121 cases of testicular primary germ cell tumor among 1157 registered patients. The median age was 37.0 years. Seminomas and non-seminomatous germ cell tumors accounted for 61.9% and 38.1%, respectively. Measurements of tumor markers were documented in 98.6% of the patients; however, there was an unsatisfactory uniform measurement of human chorionic gonadotropin, which made it difficult to evaluate the International Germ Cell Consensus Classification in all patients. The 1- and 3-year overall survival rates from the entire cohort were 98.3% and 96.8%, respectively. According to the International Germ Cell Consensus Classification, 3-year overall survival rates in the good, intermediate, and poor prognosis group were 99.1%, 100% and 79.9%, respectively.


CONCLUSIONS
The present report is the first large-scale study of the characteristics and survival of testicular cancer patients in Japan based on multi-institutional registry data, and showed a good prognosis even in an advanced stage. The improved survival attributed substantially to accurate diagnosis and effective multimodal treatment.
The Cancer Registration Committee of the Japanese Urological Association, Kyoto, Japan; Department of Urology, Graduate School of Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Tsuneharu
T
Miki
Kazumi
K
Kamoi
Hiroyuki
H
Fujimoto
Hiro-omi
HO
Kanayama
Chikara
C
Ohyama
Kazuhiro
K
Suzuki
Hiroyuki
H
Nishiyama
Masatoshi
M
Eto
Seiji
S
Naito
Tomoharu
T
Fukumori
Yoshinobu
Y
Kubota
Satoru
S
Takahashi
Kazuya
K
Mikami
Yukio
Y
Homma
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012042:Registries; D018239:Seminoma / Q000097:blood / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D013736:Testicular Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D013737:Testis / Q000473:pathology; D055815:Young Adult
D014408:Biomarkers, Tumor
Japanese; epidemiology; germ cell tumor; survival; testicular cancer