Criteria for Diagnosis of Familial Hypercholesterolemia: A Comprehensive Analysis of the Different Guidelines, Appraising their Suitability in the Omani Arab Population.
Subjects with Familial hypercholesterolemia are at increased risk for cardiac events such as premature myocardial infarction and early death from coronary heart disease, especially in patients with severe forms of the disease if left unattended. Therefore, there is an ardent need for the early diagnosis followed by aggressive therapeutic intervention and lifestyle modification. Three groups have developed clinical diagnostic tools for Familial hypercholesterolemia: the US MedPed Program, the Simon Broome Register Group in the United Kingdom, and the Dutch Lipid Clinic Network. In this article, the individual criteria are reviewed with particular emphasis on their advantage(s) and disadvantage(s), and in turn assess their suitability in diagnosing Familial hypercholesterolemia in the Omani Arab population. A brief insight into the process of "Cascade Screening" is also provided, this is a procedure that we are in the process of establishing in Oman.
Department of Clinical Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman; Department of Clinical Physiology, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman.
Khalid
K
Al-Rasadi
Department of Clinical Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman; Department of Clinical Physiology, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman.
Khalid
K
Al-Waili
Department of Surgery, Cardiothoracic Surgery Division, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman.
Hilal Ali
HA
Al-Sabti
Department of Medicine, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman.
Ali
A
Al-Hinai
Department of Medicine, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman.
Khamis
K
Al-Hashmi
Department of Pharmacology & Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
Ibrahim
I
Al-Zakwani
Department of Clinical Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman; Department of Clinical Physiology, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman.
Yajnavalka
Y
Banerjee
Cascade-Screening; Dutch Criteria; Familial hypercholesterolemia; Omani Arab Population; Simon-Broome Criteria; US-Medped Criteria