Testosterone- and cortisol-secreting adrenocortical oncocytoma: an unusual cause of hirsutism.
Objective. Oncocytomas of the adrenal cortex are usually benign and nonfunctional. They are rarely seen as the cause of hirsutism. Therefore, we aimed to report a case of adrenocortical oncocytoma presenting with hirsutism. Methods. We report a testosterone- and cortisol-secreting adrenal oncocytoma in a 23-year-old female patient presenting with hirsutism. Results. The patient had the complaint of hirsutism for the last year. Laboratory tests revealed total testosterone level of 4.2 ng/mL, free testosterone of >100 pg/mL, and DHEAS level of 574 µg/dL. There was no suppression in cortisol levels with 2 mg dexamethasone suppression test (5.4 µg/dL). Adrenal MRI revealed a 27 × 25 mm isointense solid mass lesion in the left adrenal gland and the patient underwent laparoscopic left adrenalectomy. Pathological examination confirmed the diagnosis of benign adrenocortical oncoyctoma. Conclusion. This well-characterized case describes a testosterone- and cortisol-secreting adrenocortical oncocytoma as a possible cause of hirsutism. To our knowledge, this is the second report in the literature. Adrenal oncocytomas should always be considered in the differential diagnosis of hirsutism.
Department of Endocrinology and Metabolism Disease, Recep Tayyip Erdogan University Medical School, 53020 Rize, Turkey.
Serap Baydur
SB
Sahin
Department of Surgery, Recep Tayyip Erdogan University, 53020 Rize, Turkey.
Ahmet Fikret
AF
Yucel
Department of Pathology, Recep Tayyip Erdogan University, 53020 Rize, Turkey.
Recep
R
Bedir
Department of Radiology, Recep Tayyip Erdogan University, 53020 Rize, Turkey.
Sabri
S
Ogullar
Department of Internal Medicine, Recep Tayyip Erdogan University Medical School, 53020 Rize, Turkey.
Teslime
T
Ayaz
Department of Endocrinology and Metabolism Disease, Recep Tayyip Erdogan University Medical School, 53020 Rize, Turkey.
Ekrem
E
Algun