[Cavins: new sights of caveolae-associated protein].
Caveolae are specialized lipid rafts that form flask-shaped invaginations of the plasma membrane. Many researches show that caveolae are involved in cell signaling and transport. Caveolin-1 is the major coat protein essential for the formation of caveolae. Recently, several reports indicated that the other caveolae-associated proteins, Cavins, are required for caveola formation and organization. It's worth noting that Cavin-1 could cooperate with Caveolin-1 to accommodate the structural integrity and function of caveolae. Here, we reviewed that the relationship between Cavins and Caveolins and explore the role of them in regulating caveolae.
Dan
D
Shi
Yan
Y
Liu
Xin
X
Lian
Wei
W
Zou
D000818:Animals; D021941:Caveolae / Q000502:physiology*; D051242:Caveolin 1 / Q000378:metabolism / Q000502:physiology; D022461:Caveolins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology; D016601:RNA-Binding Proteins / Q000378:metabolism / Q000502:physiology
C495540:CAV1 protein, human; C497835:CAVIN1 protein, human; D051242:Caveolin 1; D022461:Caveolins; C112745:Cavin1 protein, mouse; D008565:Membrane Proteins; D016601:RNA-Binding Proteins