Relationship between insulin-like growth factor-1 receptor and human papillomavirus in patients with oropharyngeal cancer.
BACKGROUND
Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) is associated with better prognosis than HPV-negative oropharyngeal SCC. The purpose of this study was to assess the expression of insulin-like growth factor-1 receptor (IGF-1R) in patients with oropharyngeal SCC, its relationship to HPV status and various clinical parameters, and its relationship with clinical outcome.


METHODS
The study subjects were 59 patients with oropharyngeal SCC. IGF-1R expression was examined by immunohistochemistry in paraffin-embedded tumor tissues. HPV status was evaluated by in situ hybridization (ISH) in the same tissues.


RESULTS
IGF-1R did not correlate with clinical parameters, but IGF-1R expression was more common in HPV-negative tumors than in HPV-positive tumors. The prognosis was poorer in patients of the IGF-1R-positive group than in the IGF-1R-negative group.


CONCLUSIONS
The results suggested that IGF-1R expression in oropharyngeal SCC correlated with poor prognosis in HPV-negative patients. Treatment targeting IGF-1R could potentially improve the survival of patients with HPV-negative oropharyngeal SCC.
Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Fumihiko
F
Matsumoto
Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Mitsuhisa
M
Fujimaki
Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Shinichi
S
Ohba
Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Masataka
M
Kojima
Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Junkichi
J
Yokoyama
Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Katsuhisa
K
Ikeda
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D009959:Oropharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D011379:Prognosis; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis
D017526:Receptor, IGF Type 1
head and neck cancer; human papillomavirus; insulin-like growth factor-1 receptor; oropharyngeal squamous cell carcinoma; prognosis