Cell-type-based model explaining coexpression patterns of genes in the brain.
Spatial patterns of gene expression in the vertebrate brain are not independent, as pairs of genes can exhibit complex patterns of coexpression. Two genes may be similarly expressed in one region, but differentially expressed in other regions. These correlations have been studied quantitatively, particularly for the Allen Atlas of the adult mouse brain, but their biological meaning remains obscure. We propose a simple model of the coexpression patterns in terms of spatial distributions of underlying cell types and establish its plausibility using independently measured cell-type-specific transcriptomes. The model allows us to predict the spatial distribution of cell types in the mouse brain.
Department of Mathematical Sciences, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.
Pascal
P
Grange
Jason W
JW
Bohland
Benjamin W
BW
Okaty
Ken
K
Sugino
Hemant
H
Bokil
Sacha B
SB
Nelson
Lydia
L
Ng
Michael
M
Hawrylycz
Partha P
PP
Mitra
D000818:Animals; D001921:Brain / Q000378:metabolism*; D015870:Gene Expression; D051379:Mice; D008954:Models, Biological
bioinformatics; neuroanatomy; neuroscience