Effectiveness of infliximab in the treatment of perianal fistulas in ulcerative colitis: report of two cases.
Ulcerative colitis is a chronic inflammatory bowel disease of unknown etiopathogenesis and increasing incidence in recent years. Perianal complications of ulcerative colitis are rare and seem to be associated with higher extent of inflammation and a more severe course of the disease. The cases of two male patients with severe corticoid-dependent ulcerative colitis of protracted clinical course who developed perianal fistulas and abscesses successfully treated with infliximab are reported. Treatment with infliximab was followed by perianal fistula closure with marked improvement in the quality of life over 2-year follow-up period.
Service of Gastroenterology, Hospital Universitario de Álava (HUA)-Sede Txagorritxu, Vitoria-Gasteiz, Spain.
Patricia Ramírez
PR
de la Piscina
Service of Gastroenterology, Hospital Universitario de Álava (HUA)-Sede Txagorritxu, Vitoria-Gasteiz, Spain.
Ileana
I
Duca
Service of Gastroenterology, Hospital Universitario de Álava (HUA)-Sede Txagorritxu, Vitoria-Gasteiz, Spain.
Silvia
S
Estrada
Service of Gastroenterology, Hospital Universitario de Álava (HUA)-Sede Txagorritxu, Vitoria-Gasteiz, Spain.
Katerina
K
Spicakova
Service of Gastroenterology, Hospital Universitario de Álava (HUA)-Sede Txagorritxu, Vitoria-Gasteiz, Spain.
Rosario
R
Calderón
Service of Gastroenterology, Hospital Universitario de Álava (HUA)-Sede Txagorritxu, Vitoria-Gasteiz, Spain.
Leire
L
Urtasun
Universidad del País Vasco, Vitoria-Gasteiz, Spain.
Carlos
C
Marra-López
Universidad del País Vasco, Vitoria-Gasteiz, Spain.
Marta
M
Salvador
Universidad del País Vasco, Vitoria-Gasteiz, Spain.
Elvira
E
Delgado
Universidad del País Vasco, Vitoria-Gasteiz, Spain.
Francisco García
FG
Campos
Infliximab; Ulcerative colitis; perianal fistulas