Luliconazole demonstrates potent in vitro activity against dermatophytes recovered from patients with onychomycosis.
The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents. The in vitro potency of luliconazole was maintained regardless of the dermatophyte species.
The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Nathan P
NP
Wiederhold
The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Annette W
AW
Fothergill
The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Dora I
DI
McCarthy
Topica Pharmaceuticals, Inc., Los Altos, California, USA atavakkol@topicapharma.com.
Amir
A
Tavakkol
D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D000077768:Ciclopirox; D003881:Dermatomycoses / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009025:Morpholines / Q000494:pharmacology; D009281:Naphthalenes / Q000494:pharmacology; D014009:Onychomycosis / Q000150:complications / Q000382:microbiology*; D011728:Pyridones / Q000494:pharmacology; D000077291:Terbinafine
D000935:Antifungal Agents; D007093:Imidazoles; D009025:Morpholines; D009281:Naphthalenes; D011728:Pyridones; D000077768:Ciclopirox; C038974:amorolfine; D000077291:Terbinafine; C112528:luliconazole