Overview of vertebrate animal models of fungal infection.
Fungi represent emerging infectious threats to human populations worldwide. Mice and other laboratory animals have proved invaluable in modeling clinical syndromes associated with superficial and life-threatening invasive mycoses. This review outlines salient features of common vertebrate animal model systems to study fungal pathogenesis, host antifungal immune responses, and antifungal compounds.
Department of Medicine, Infectious Diseases Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 9, New York, NY 10075, United States. Electronic address: hohlt@mskcc.org.
Tobias M
TM
Hohl
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D009181:Mycoses / Q000276:immunology / Q000378:metabolism / Q000473:pathology
Animal model; Fungus; Immune response; Mouse; Pathogenesis; Yeast