Relation of carotid plaque with natural IgM antibodies in patients with systemic lupus erythematosus.
Noninvasive carotid measurements have proven value in the estimation of future cardiovascular (CV) outcomes in systemic lupus erythematosus (SLE). Natural IgM-antibodies to phosphorylcholine (PC) epitopes can enhance apoptotic-cell clearance and induce anti-inflammatory pathways. Herein, we show that subclinical CV disease, as detected by carotid ultrasound, in a cross-sectional SLE cohort was associated with lower levels of IgM anti-PC, as well as lower levels of the ratio of IgM anti-PC/total IgM, compared to patients without plaque (p=0.004 and p=0.02, respectively). The IgM anti-PC/total IgM association remained significant after adjusting for age, cholesterol and hypertension. Adiponectin and sE-selectin were significantly elevated in patients with plaque, and statistical models showed that combining adiponectin, sE-selectin and IgM anti-PC/total IgM was better for predicting plaque than either test alone. These results support the hypothesis that IgM-natural autoantibodies may inhibit atherogenesis, and confirm the utility of IgM anti-PC levels as a biomarker for subclinical CV disease.
Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, USA. Electronic address: caroline.gronwall@nyumc.org.
Caroline
C
Grönwall
Department of Medicine, Division of Cardiology, New York University School of Medicine, New York, NY, USA.
Harmony
H
Reynolds
Department of Population Health, Division of Biostatistics, New York University, New York, NY, USA.
June K
JK
Kim
Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, USA.
Jill
J
Buyon
Department of Population Health, Division of Biostatistics, New York University, New York, NY, USA.
Judith D
JD
Goldberg
Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, USA.
Robert M
RM
Clancy
Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, USA.
Gregg J
GJ
Silverman
D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D015415:Biomarkers; D002339:Carotid Arteries / Q000473:pathology*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010767:Phosphorylcholine / Q000276:immunology; D058226:Plaque, Atherosclerotic / Q000276:immunology*; D012307:Risk Factors
D001323:Autoantibodies; D015415:Biomarkers; D007075:Immunoglobulin M; D010767:Phosphorylcholine
Adiponectin; Atherosclerosis; E-selectin; IgM; Phosphorylcholine; Systemic lupus erythematosus