Maternal, placental and fetal exposure to bisphenol A in women with and without preeclampsia.
OBJECTIVE
We aimed to investigate potential association between the exposure of bisphenol A (BPA) and preeclampsia.


METHODS
Concentrations of BPA were assessed in 58 pregnancies including 35 normotensive and 23 preeclamptic women, using a highly sensitive gas chromatography-mass spectrometry (GC-MS) method.


RESULTS
BPA was detected in maternal blood, fetal blood and placental tissue; and actual concentrations of BPA were determined. Interestingly, significant accumulation of BPA in the placentas of women with preeclampsia compared to normotensive women has been shown.


CONCLUSIONS
This is the first study to highlight a significant correlation between preeclampsia and a high accumulation of BPA in the placenta.
Department of Obstetrics and Gynecology .
François
F
Leclerc
Marie-France
MF
Dubois
Aziz
A
Aris
D000328:Adult; D001559:Benzhydryl Compounds / Q000032:analysis* / Q000633:toxicity; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D018811:Maternal Exposure / Q000009:adverse effects*; D010636:Phenols / Q000032:analysis* / Q000633:toxicity; D010920:Placenta / Q000737:chemistry*; D011225:Pre-Eclampsia / Q000139:chemically induced*; D011247:Pregnancy; D055815:Young Adult; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
Bisphenol A; Fetal blood; Maternal blood; Placenta; Preeclampsia.