Conformational dynamics through an intermediate.
The self-assembly of biological and synthetic nanostructures commonly proceeds via intermediate states. In living systems in particular, the intermediates have the capacity to tilt the balance between functional and potentially fatal behavior. This work develops a statistical mechanical treatment of conformational dynamics through an intermediate under a variable force. An analytical solution is derived for the key experimentally measurable quantity-the distribution of forces at which a conformational transition occurs. The solution reveals rich kinetics over a broad range of parameters and enables one to locate the intermediate and extract the activation barriers and rate constants.
Department of Physics and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093, USA.
Ashok
A
Garai
Department of Physics and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093, USA.
Yaojun
Y
Zhang
Department of Physics and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093, USA.
Olga K
OK
Dudko
D001669:Biochemical Phenomena; D007700:Kinetics; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry; D013816:Thermodynamics