Statistical analysis of observational study of the influence of radon and other risk factors on lung cancer incidence.
An observational study is a type of epidemiological study when the researcher observes the situation but is not able to change the conditions of the experiment. The statistical analysis of the observational study of the population of Lermontov city (North Caucasus) was conducted. In the initial group, there were 121 people with lung cancer diagnosis and 196 people of the control group. Statistical analysis was performed only for men (95 cases and 76 controls). The use of logistic regression with correction on age gives the value of odds ratio 1.95 (0.87÷4.37; 90% CI) per 100 working levels per month of combined (occupational and domestic) radon exposure. It was demonstrated that chronic lung diseases are an additional risk factor for uranium miners but it is not a significant risk factor for general population. Thus, the possibility of obtaining statistically reliable results in the observational studies when using the correct methods of analysis is demonstrated.
Institute of Industrial Ecology UB RAS, Ekaterinburg, Russia michael@ecko.uran.ru.
Michael
M
Zhukovsky
Institute of Industrial Ecology UB RAS, Ekaterinburg, Russia.
Anatole
A
Varaksin
Institute of Industrial Ecology UB RAS, Ekaterinburg, Russia.
Olga
O
Pakholkina
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000396:Air Pollutants, Radioactive / Q000009:adverse effects*; D016022:Case-Control Studies; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D008906:Mining; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects*; D011379:Prognosis; D011886:Radon / Q000009:adverse effects*; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D014501:Uranium / Q000009:adverse effects
D000396:Air Pollutants, Radioactive; D014501:Uranium; D011886:Radon