Differences in MCT1 A1470T polymorphism prevalence between runners and swimmers.
Skeletal muscle is the major producer and user of lactate in the body. Therefore, transport of lactate across cells' membrane is of considerable importance. Lactate transport is mediated by proton-linked monocarboxylate transporter (MCT1). The A1470T polymorphism (rs1049434) in MCT1 gene influences lactate transport, with T allele associated with reduction of lactate transport rate and elevation in blood lactate levels. The aim of the current study was to compare allelic and genotype frequencies of MCT1 A1470T polymorphism among Israeli track-and-field athletes, swimmers, and non-athletes. Genomic DNA was extracted from 173 track-and-field athletes (age 17-50), 80 swimmers (age 16-49), and 128 non-athletes (age 19-29). Track-and-field athletes were assigned to three subgroups: long-distance runners, middle-distance runners, and power event athletes. Swimmers were assigned to two subgroups: long-distance swimmers and short-distance swimmers. Genotyping was performed using polymerase chain reaction. T-allele frequency was significantly higher among long-distance swimmers (45%) compared with long- and middle-distance runners (27% and 30%, respectively; P < 0.01). In addition, T-allele frequency was significantly higher among short-distance swimmers (40%) compared with power event athletes (25%, P < 0.01). Overall, T-allele frequency was significantly higher among swimmers (42%) compared with runners (27%, P < 0.001). More research is needed to clarify whether this polymorphism displays advantage for swimming performance.
Genetics and Molecular Biology Laboratory, The Zinman College of Physical Education and Sports Sciences at the Wingate Institute, Netanya, Israel.
S
S
Ben-Zaken
Pediatric Department, Child Health and Sports Center, Meir Medical Center, Kfar-Saba, Israel.
A
A
Eliakim
Pediatric Department, Child Health and Sports Center, Meir Medical Center, Kfar-Saba, Israel.
D
D
Nemet
Genetics and Molecular Biology Laboratory, The Zinman College of Physical Education and Sports Sciences at the Wingate Institute, Netanya, Israel.
M
M
Rabinovich
Pediatric Department, Hillel-Yafe Medical Center, Hadera, Israel.
E
E
Kassem
Genetics and Molecular Biology Laboratory, The Zinman College of Physical Education and Sports Sciences at the Wingate Institute, Netanya, Israel.
Y
Y
Meckel
D000293:Adolescent; D000328:Adult; D056352:Athletes; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D027501:Monocarboxylic Acid Transporters / Q000235:genetics*; D011110:Polymorphism, Genetic; D012420:Running; D013550:Swimming; D027981:Symporters / Q000235:genetics*; D055815:Young Adult; D000099233:Monocarboxylate Transport Protein 1
D027501:Monocarboxylic Acid Transporters; D027981:Symporters; D000099233:Monocarboxylate Transport Protein 1
MCT1 polymorphism; lactate transport; runners; swimmers