Lipid levels in dissociative disorders: effects of psychodynamic psychotherapy.
Although there are several data suggesting a link between lower lipids levels and the risk of suicide, there are few data concerning lower lipids levels in patients with dissociative disorders (DD). This is the first longitudinal study investigating the evolution of the lipids levels during a specific 8 weeks of psychodynamic psychotherapy (PP) for patients with DD. 32 patients diagnosed with DD (SCID for DSMIVR) were assessed with Dissociative Experiences Scale (DES), Clinical Global Impression and Improvement Scale and their lipids levels (total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein and very low density lipoprotein) were measured at inclusion and after 3 and 8 weeks of PP. 30 patients finished the study. There is a significant positive (p < 0.05) link between lower lipids levels (total cholesterol, LDL, triglycerids) and a higher level of dissociation (DES scores) at the beginning and at the end of the study. Interestingly, we found a significant (p = 0.018) positive link between the reduction of the dissociation (DES) and the increase of the triglycerides levels after 8 weeks of treatment. While lower lipids seems related to a higher level of dissociation before and after the treatment, an increasing triglycerides level was observed after 8 weeks of PP in patients with a better outcome. Further studies are needed with larger samples and control groups, in order to confirm these preliminary data. These findings could open the way for hypothesis about the role of lipids in the pathophysiology of DD and raise the question of the patients with DD receiving antilipidemiants agents.
Department of Psychiatry, Clinical Investigation Program, University of Colorado Health Sciences Center, 4455 East 12th Avenue, Denver, CO, 80220, USA, c.damsa@bluewin.ch.
Cristian
C
Damsa
Coralie
C
Lazignac
Nick
N
Miller
Susanne
S
Maris
Eric
E
Adam
Kevin
K
Rossignon
D000328:Adult; D004213:Dissociative Disorders / Q000097:blood* / Q000628:therapy*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D064889:Psychotherapy, Psychodynamic / Q000379:methods*; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood*
D008074:Lipoproteins; D014280:Triglycerides