[Ceftaroline, a new broad-spectrum cephalosporin in the era of multiresistance].
Antimicrobial resistance has increased during the last few years, representing a public health concern. Among Gram-positive organisms, methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae are paradigms of resistance and of the dispersion of multiresistant clones. Ceftaroline, a broad-spectrum cephalosporin that includes MRSA and penicillin-resistant S. pneumoniae, is the first β-lactam antibiotic useful in infections due to MRSA. Phase-III clinical trials have demonstrated its efficacy in the treatment of community-acquired pneumonia and in skin and soft tissue infections, which are the current indications for ceftaroline. Due to its microbiological and pharmacological (PK/PD) profiles, these indications could be expanded to include bacteremia, endocarditis, and even osteoarticular infections. Another notable feature is the activity of this drug against Gram-negative bacilli susceptible to third generation cephalosporins, indicating that ceftaroline could be useful when these organisms are suspected or demonstrated in polymicrobial infections. Clinical follow-up of ceftaroline use will more clearly define future ceftaroline indications.
Servicio de Enfermedades Infecciosas, Hospital Universitario del Mar, Institut Hospital del Mar d'Investigació Mèdica (IMIM), Barcelona, España.
Juan Pablo
JP
Horcajada
Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, España. Electronic address: rafael.canton@salud.madrid.org.
Rafael
R
Cantón
D002511:Cephalosporins / Q000494:pharmacology / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus; D013203:Staphylococcal Infections / Q000188:drug therapy*; D000097583:Ceftaroline
D002511:Cephalosporins; D000097583:Ceftaroline
Ceftarolina; Ceftaroline; MRSA; Multiresistant; Multirresistente; New antimicrobials; Nuevos antimicrobianos; SARM; Streptococcus pneumoniae