Synthesis and in-vivo hypolipidemic activity of some novel substituted phenyl isoxazol phenoxy acetic acid derivatives.
The present study was undertaken to evaluate in-vivo hypolipidemic activity of a novel series of 2-methyl-2-(substituted phenyl isoxazol)phenoxyacetic acid derivatives by triton induced hyperlipidemia in rats. The newly synthesized compounds 5a, 5d and 5g showed significant decrease in the serum TCH, TG, LDL and VLDL along with an increase in serum HDL levels as compared to standard drug Fenofibrate. The treated groups also showed significant decrease in the atherogenic index and increase in % protective activity compared to control group.
Dr. Rafiq Zakaria Campus, Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Aurangabad 431001, M.S., India. Electronic address: santoshmokale@rediffmail.com.
Santosh N
SN
Mokale
Dr. Rafiq Zakaria Campus, Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Aurangabad 431001, M.S., India.
Manjusha C
MC
Nevase
Dr. Rafiq Zakaria Campus, Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Aurangabad 431001, M.S., India.
Nikhil S
NS
Sakle
Dr. Rafiq Zakaria Campus, Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Aurangabad 431001, M.S., India.
Pritam N
PN
Dube
Dr. Rafiq Zakaria Campus, Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Aurangabad 431001, M.S., India.
Vishakha R
VR
Shelke
Dr. Rafiq Zakaria Campus, Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Aurangabad 431001, M.S., India.
Swati A
SA
Bhavale
Dr. Rafiq Zakaria Campus, Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Aurangabad 431001, M.S., India.
Afreen
A
Begum
D000085:Acetates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000737:Androstenols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000085:Acetates; D000737:Androstenols; D000960:Hypolipidemic Agents; D008055:Lipids; C017039:azastene; C415326:phenoxyacetic acid
Anti-atherosclerotic; Hyperlipidemia; Isoxazol; Phenoxy acetic acid