Involvement of oxidative stress and inflammation in liver injury caused by perfluorooctanoic acid exposure in mice.
Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that the exposure to PFOA for 14 consecutive days led to serious hepatocellular injury and obvious inflammatory cell infiltration. In addition, malondialdehyde formation and hydrogen peroxide generation, indicators of oxidative stress, were significantly induced by PFOA treatment in the liver of mice. Furthermore, hepatic levels of interleukin-6, cyclooxygenase-2, and C-reactive protein, markers of inflammatory response, were markedly increased by exposure to PFOA in mice. These results demonstrated that PFOA-induced hepatic toxicity may be involved in oxidative stress and inflammatory response in mice.
Department of Physiology, Medical College of Nanchang University, Nanchang 330006, China.
Bei
B
Yang
Department of Physiology, Medical College of Nanchang University, Nanchang 330006, China.
Weiying
W
Zou
Department of Pathophysiology, Medical College of Nanchang University, Nanchang 330006, China.
Zhenzhen
Z
Hu
Library of Nanchang University, Nanchang 330006, China.
Fangming
F
Liu
Nanchang Medical School, Nanchang 330006, China.
Ling
L
Zhou
Department of Physiology, Medical College of Nanchang University, Nanchang 330006, China.
Shulong
S
Yang
Department of Physiology, Medical College of Nanchang University, Nanchang 330006, China.
Haibin
H
Kuang
Department of Physiology, Medical College of Nanchang University, Nanchang 330006, China.
Lei
L
Wu
Department of Physiology, Medical College of Nanchang University, Nanchang 330006, China.
Jie
J
Wei
Department of Physiology, Medical College of Nanchang University, Nanchang 330006, China.
Jinglei
J
Wang
Department of Physiology, Medical College of Nanchang University, Nanchang 330006, China.
Ting
T
Zou
Department of Physiology, Medical College of Nanchang University, Nanchang 330006, China.
Dalei
D
Zhang
D000818:Animals; D002210:Caprylates / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005466:Fluorocarbons / Q000633:toxicity*; D006505:Hepatitis / Q000209:etiology* / Q000378:metabolism*; D007155:Immunologic Factors / Q000378:metabolism; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D002210:Caprylates; D005466:Fluorocarbons; D007155:Immunologic Factors; D017382:Reactive Oxygen Species; C023036:perfluorooctanoic acid