Short-term clinical outcomes among patients undergoing transcatheter aortic valve implantation in Switzerland: the Swiss TAVI registry.
OBJECTIVE
To evaluate short-term clinical outcomes following transcatheter aortic valve implantation (TAVI) using CE-mark approved devices in Switzerland.


RESULTS
The Swiss TAVI registry is a national, prospective, multicentre, monitored cohort study evaluating clinical outcomes in consecutive patients undergoing TAVI at cardiovascular centres in Switzerland. From February 2011 to March 2013, a total of 697 patients underwent TAVI for native aortic valve stenosis (98.1%), degenerative aortic bioprosthesis (1.6%) or severe aortic regurgitation (0.3%). Patients were elderly (82.4±6 years), 52% were females, and the majority highly symptomatic (73.1% NYHA III/IV). Patients with severe aortic stenosis (mean gradient 44.8±17 mmHg, aortic valve area 0.7±0.3 cm²) were either deemed inoperable or at high risk for conventional surgery (STS 8.2%±7). The transfemoral access was the most frequently used (79.1%), followed by transapical (18.1%), direct aortic (1.7%) and subclavian access (1.1%). At 30 days, rates of all-cause mortality, cerebrovascular events and myocardial infarction were 4.8%, 3.3% and 0.4%, respectively. The most frequently observed adverse events were access-related complications (11.8%), permanent pacemaker implantation (20.5%) and bleeding complications (16.6%). The Swiss TAVI registry is registered at ClinicalTrials.gov (NCT01368250).


CONCLUSIONS
The Swiss TAVI registry is a national cohort study evaluating consecutive TAVI procedures in Switzerland. This first outcome report provides favourable short-term clinical outcomes in unselected TAVI patients.
Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland.
Peter
P
Wenaweser
Stefan
S
Stortecky
Dik
D
Heg
David
D
Tueller
Fabian
F
Nietlispach
Volkmar
V
Falk
Giovanni
G
Pedrazzini
Raban
R
Jeger
Oliver
O
Reuthebuch
Thierry
T
Carrel
Lorenz
L
Räber
Franz W
FW
Amann
Enrico
E
Ferrari
Stefan
S
Toggweiler
Stephane
S
Noble
Marco
M
Roffi
Jürg
J
Gruenenfelder
Peter
P
Jüni
Stephan
S
Windecker
Christoph
C
Huber
D000368:Aged; D000369:Aged, 80 and over; D001022:Aortic Valve Insufficiency / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000601:surgery*; D001705:Bioprosthesis; D006328:Cardiac Catheterization / Q000379:methods; D015331:Cohort Studies; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011475:Prosthesis Failure; D012042:Registries; D012720:Severity of Illness Index; D013557:Switzerland; D065467:Transcatheter Aortic Valve Replacement / Q000379:methods*; D016896:Treatment Outcome