Diversity study of 12 X-chromosomal STR loci in Hui ethnic from China.
X-chromosomal STRs (X-STRs) have been used as complements of autosomal STR application in recent years. In this work, we present population genetic data of 12 X-STRs including DXS101, DXS10159, DXS10162, DXS10164, DXS6789, DXS7133, DXS7423, DXS7424, DXS8378, DXS981, GATA165B12, and GATA31E08 loci in a sample of 231 unrelated healthy individuals from the Hui ethnic group in Ningxia Hui Autonomous Region, China. Allelic frequencies of the 12 X-STR loci and haplotypic frequencies of the reported linkage groups (DXS7424-DXS101 and DXS10159-DXS10164-DXS10162) were investigated in the group, respectively. No STR loci showed significant deviations from the Hardy-Weinberg equilibriums and no linkage disequilibriums of pairwise loci were found after Bonferroni correction, respectively. A combined power of discrimination in female individuals was 0.999999999985 and that in male individuals was 0.99999967, respectively. The combined mean exclusion chance in deficiency cases, normal trios and duo cases were 0.999934, 0.995754, and 0.999796, respectively. Significant differences were observed from 0 to 8 loci, when making comparisons between the data of Hui ethnic group and previously reported data from other 16 populations. The results indicated the new panel of 12 X-STR loci might be useful for forensic science application.
Xi'an Jiaotong University, Health Science Center, Xi'an, P. R. China***
Hao-Tian
HT
Meng
Jun-Tao
JT
Han
Yu-Dang
YD
Zhang
Wen-Juan
WJ
Liu
Tian-Ju
TJ
Wang
Jiang-Wei
JW
Yan
Jing-Feng
JF
Huang
Wei-An
WA
Du
Jian-Xin
JX
Guo
Hong-Dan
HD
Wang
Yu-Hong
YH
Zhang
Ru-Hua
RH
Zhou
Bo-Feng
BF
Zhu
Xing
X
Wei
D044466:Asian People / Q000235:genetics*; D002681:China; D041321:Chromosomes, Human, X; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005828:Genetics, Population / Q000379:methods*; D060005:Genotyping Techniques; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic
Genetic polymorphisms; Hui ethnic group; Population genetics; X-STRs