Fetus sound stimulation: cilia memristor effect of signal transduction.
BACKGROUND
This experimental study evaluates fetal middle cerebral artery (MCA) circulation after the defined prenatal acoustical stimulation (PAS) and the role of cilia in hearing and memory and could explain signal transduction and memory according to cilia optical-acoustical properties.


METHODS
PAS was performed twice on 119 no-risk term pregnancies. We analyzed fetal MCA circulation before, after first and second PAS.


RESULTS
Analysis of the Pulsatility index basic (PIB) and before PAS and Pulsatility index reactive after the first PAS (PIR 1) shows high statistical difference, representing high influence on the brain circulation. Analysis of PIB and Pulsatility index reactive after the second PAS (PIR 2) shows no statistical difference. Cilia as nanoscale structure possess magnetic flux linkage that depends on the amount of charge that has passed between two-terminal variable resistors of cilia. Microtubule resistance, as a function of the current through and voltage across the structure, leads to appearance of cilia memory with the "memristor" property.


CONCLUSIONS
Acoustical and optical cilia properties play crucial role in hearing and memory processes. We suggest that fetuses are getting used to sound, developing a kind of memory patterns, considering acoustical and electromagnetically waves and involving cilia and microtubules and try to explain signal transduction.
Department of Obstetrics and Gynecology "Narodni front", Kraljice Natalije Street 62, 11000 Belgrade, Serbia ; Belgrade University Medical School, Doktora Subotica Street 8, 11000 Belgrade, Serbia.
Svetlana
S
Jankovic-Raznatovic
Department of Obstetrics and Gynecology "Narodni front", Kraljice Natalije Street 62, 11000 Belgrade, Serbia ; Belgrade University Medical School, Doktora Subotica Street 8, 11000 Belgrade, Serbia.
Svetlana
S
Dragojevic-Dikic
Department of Obstetrics and Gynecology "Narodni front", Kraljice Natalije Street 62, 11000 Belgrade, Serbia ; Belgrade University Medical School, Doktora Subotica Street 8, 11000 Belgrade, Serbia.
Snezana
S
Rakic
Department of Obstetrics and Gynecology "Narodni front", Kraljice Natalije Street 62, 11000 Belgrade, Serbia ; Belgrade University Medical School, Doktora Subotica Street 8, 11000 Belgrade, Serbia.
Branka
B
Nikolic
Belgrade University Medical School, Doktora Subotica Street 8, 11000 Belgrade, Serbia ; Institute for Obstetrics and Gynecology, Clinical Center of Serbia, Majke Jevrosime 8, 11000 Belgrade, Serbia.
Snezana
S
Plesinac
Department of Obstetrics and Gynecology "Narodni front", Kraljice Natalije Street 62, 11000 Belgrade, Serbia ; Belgrade University Medical School, Doktora Subotica Street 8, 11000 Belgrade, Serbia.
Lidija
L
Tasic
Department of Obstetrics and Gynecology "Narodni front", Kraljice Natalije Street 62, 11000 Belgrade, Serbia ; Belgrade University Medical School, Doktora Subotica Street 8, 11000 Belgrade, Serbia.
Zivko
Z
Perisic
Institute for Experimental Phonetics and Speech Pathology, Gospodar Jovanova Street 35, 11000 Belgrade, Serbia ; Life Activities Advancement Center, Gospodar Jovanova Street 35, 11000 Belgrade, Serbia.
Mirjana
M
Sovilj
Institute for Experimental Phonetics and Speech Pathology, Gospodar Jovanova Street 35, 11000 Belgrade, Serbia ; Life Activities Advancement Center, Gospodar Jovanova Street 35, 11000 Belgrade, Serbia.
Tatjana
T
Adamovic
Biomedical engineering, Faculty of Mechanical Engineering, University of Belgrade, Kraljice Marije Street 8, 11000 Belgrade, Serbia.
Djuro
D
Koruga
D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D002923:Cilia / Q000378:metabolism / Q000648:ultrastructure; D004574:Electromagnetic Fields; D005260:Female; D005333:Fetus / Q000528:radiation effects; D005865:Gestational Age; D006801:Humans; D020768:Middle Cerebral Artery / Q000196:embryology* / Q000528:radiation effects; D011247:Pregnancy; D015398:Signal Transduction; D016216:Ultrasonography, Prenatal