The location of pretreatment hyperdense middle cerebral artery sign predicts the outcome of intraarterial thrombectomy for acute stroke.
OBJECTIVE
Intraarterial (IA) mechanical thrombectomy has an excellent recanalization rate but does not always correlate with good clinical outcomes. We aimed to investigate whether hyperdense middle cerebral artery sign (HMCAS) on preintervention nonenhanced CT (NECT) predicts IA therapy outcome for acute stroke.


METHODS
Data were abstracted from our Hyperacute Ischemic Stroke database. Patients with occlusion in ICA, MCA, or MCA M2 branches who underwent IA therapy were included.


RESULTS
Among 126 patients who underwent IA treatment, 64 (51%) had hyperdense M1 MCA sign (M1 HMCAS), 11 (9%) had hyperdense M2, and 51 (40%) had No HMCAS (NHMCAS).M1 HMCAS and NHMCAS group has comparable baseline stroke severity and infarct volume (P > .05); and the differences of favorable outcome (modified Rankin Score 0-2) at 30 days were not significant (21% vs. 30%, P = .259). For those with HMCAS, favorable 30-day outcome was most frequent in Distal HMCAS (39%), followed by hyperdense M2 (27%), HMCAS proximal (11%), and HMCAS full length (0%).


CONCLUSIONS
For acute ischemic stroke due to large vessel occlusion, the lack of HMCAS on NECT does not predict favorable outcome after IA therapy. Among those with HMCAS, proximal and longer HMCAS predicts unfavorable outcome.
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Shumei
S
Man
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Muhammad Shazam
MS
Hussain
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Dolora
D
Wisco
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Irene L
IL
Katzan
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Junya
J
Aoki
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Yohei
Y
Tateishi
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Esteban
E
Cheng-Ching
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Ferdinand K
FK
Hui
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Thomas J
TJ
Masaryk
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Peter A
PA
Rasmussen
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Ken
K
Uchino
D000368:Aged; D002533:Cerebral Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D061185:Mechanical Thrombolysis / Q000379:methods*; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging*; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D020521:Stroke / Q000000981:diagnostic imaging* / Q000601:surgery*
Hyperdense MCA sign; mechanical thrombectomy; outcome; stroke