Cancer Antigen-125 as a marker of ascites in patients with liver cirrhosis.
OBJECTIVE
To evaluate the correlation between Cancer Antigen-25 (CA-125) levels with the amount of ascites in patients with liver cirrhosis.


METHODS
Observational, analytical study.


METHODS
Shifa International Hospital, Islamabad, from March 2012 to February 2013.


METHODS
A total of 130 patients with liver cirrhosis (with and without ascites) had serum CA-125 levels measured. The amount of ascites was classified according to physical examination and ultrasound (USG) findings. CA-125 levels were compared and correlated with amount of ascites.


RESULTS
Majority of patients (57%) had hepatitis C virus and 60% were in class Child Pugh C. There was moderate correlation between amount of ascites and CA-125 levels (r = 0.642, p < 0.001) with significant raised levels of CA-125 in patients with ascites (p < 0.001).


CONCLUSIONS
There was a moderate correlation between CA-125 levels and presence and amount of ascites.
Department of Gastroenterology, Shifa International Hospital, Islamabad.
Muhammad Omar
MO
Qureshi
Department of Gastroenterology, Shifa International Hospital, Islamabad.
Faisal Saud
FS
Dar
Department of Gastroenterology, Shifa International Hospital, Islamabad.
Nasir
N
Khokhar
D000328:Adult; D000368:Aged; D001201:Ascites / Q000000981:diagnostic imaging / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography
D015415:Biomarkers; D018394:CA-125 Antigen