diRNA-Ago2-RAD51 complexes at double-strand break sites.
The way in which the DNA damage response signals the presence of DNA lesions and mediates DNA repair has not been fully elucidated. Now, Gao et al. reveal that diRNA-Ago2 complexes recruit RAD51 to the break sites.
Department of Molecular Biology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Soichiro
S
Yamanaka
Department of Molecular Biology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Haruhiko
H
Siomi
D060565:Argonaute Proteins / Q000378:metabolism*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D059765:Homologous Recombination; D006801:Humans; D051135:Rad51 Recombinase / Q000378:metabolism*
C466422:AGO2 protein, human; D060565:Argonaute Proteins; D051135:Rad51 Recombinase