DNA vaccination as a treatment for chronic kidney disease.
Chronic kidney disease is one of the major health problems worldwide. DNA vaccination delivers plasmid DNA encoding the target gene to induce both humoral and cellular immune responses. Here, we describe the methods of CD40 DNA vaccine enhanced by dendritic cell (DC) targeting on the development of Heymann nephritis (HN), a rat model of human membranous nephropathy.
Centre for Kidney Research, Children's Hospital at Westmead, The University of Sydney, Level 2, Crn Hawkesbury Road, Hainsworth Street, Sydney, NSW, 2145, Australia, yuan.wang@health.nsw.gov.au.
Yuan Min
YM
Wang
Stephen I
SI
Alexander
D000818:Animals; D000941:Antigens / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007684:Kidney Tubules / Q000276:immunology; D008297:Male; D051381:Rats; D051436:Renal Insufficiency, Chronic / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D014611:Vaccination; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology*
D000941:Antigens; D019444:Vaccines, DNA