Important role of autophagy in regulation of metabolic processes in health, disease and aging.
Autophagy is the basic catabolic mechanism that involves degradation of dysfunctional cellular components through the action of lysosome as well as supplying energy and compounds for the synthesis of essential biomacromolecules. This process enables cells to survive stress from the external environment like nutrient deprivation. Autophagy is important in the breakdown of proteins, carbohydrates and lipids as well. Furthermore, recent studies have shown that autophagy is critical in wide range of normal human physiological processes, and defective autophagy is associated with diverse diseases, including lysosomal storage disease, myopathies, neurodegeneration and various metabolic disorders. This review summarizes the most up-to-date findings on what role autophagy plays in metabolism.
Institute for Clinical and Experimental Medicine, Department of Metabolism and Diabetes, Prague, Czech Republic. monika.cahova@ikem.cz.
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D000375:Aging / Q000502:physiology*; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D004194:Disease; D006262:Health; D006801:Humans; D008660:Metabolism / Q000502:physiology*