Interleukin 15 receptor alpha rs2228059 A > C polymorphism decreased risk of gastric cardiac adenocarcinoma in a Chinese population.
Gastric cardiac adenocarcinoma (GCA) is one of the common malignant tumors in the world and has a high incidence in China. Both environmental risk factors and genetic factors might play an essential role in the GCA carcinogenesis. We performed a hospital-based case-control study to evaluate the genetic effects of interleukin 15 (IL15) and IL15 receptor alpha (IL15RA) functional single nucleotide polymorphisms (SNPs) on the pathogenesis of GCA. A total of 243 GCA cases and 476 controls were enrolled in this study. The genotypes were determined using a custom-by-design 48-Plex SNPscan(TM) Kit. When the IL15RA rs2228059 AA homozygote genotype was used as the reference group, the CC genotype was correlated with a significantly decreased risk for GCA (CC vs. AA: adjusted OR = 0.61, 95 % CI = 0.37-0.98, p = 0.042). Our results revealed that functional variant IL15RA rs2228059 A > C might attenuate individual's risk of GCA. However, there was no significant association between the other five IL15 SNPs and GCA susceptibility. This present study demonstrated that IL15RA rs2228059 A > C polymorphism might modify GCA susceptibility. The results were based on a limited sample size; future larger studies with more rigorous designs are warranted to validate our findings.
Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, 212002, China.
Jun
J
Yin
Chao
C
Liu
Xu
X
Wang
Liming
L
Wang
Yijun
Y
Shi
Weifeng
W
Tang
Guowen
G
Ding
Ruiping
R
Liu
Suocheng
S
Chen
Haiyong
H
Gu
Liang
L
Zheng
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D053720:Interleukin-15 Receptor alpha Subunit / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
D053720:Interleukin-15 Receptor alpha Subunit