P300 amplitude variation is related to ventral striatum BOLD response during gain and loss anticipation: an EEG and fMRI experiment.
The anticipation of favourable or unfavourable events is a key component in our daily life. However, the temporal dynamics of anticipation processes in relation to brain activation are still not fully understood. A modified version of the monetary incentive delay task was administered during separate functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG) sessions in the same 25 participants to assess anticipatory processes with a multi-modal neuroimaging set-up. During fMRI, gain and loss anticipation were both associated with heightened activation in ventral striatum and reward-related areas. EEG revealed most pronounced P300 amplitudes for gain anticipation, whereas CNV amplitudes distinguished neutral from gain and loss anticipation. Importantly, P300, but not CNV amplitudes, were correlated to neural activation in the ventral striatum for both gain and loss anticipation. Larger P300 amplitudes indicated higher ventral striatum blood oxygen level dependent (BOLD) response. Early stimulus evaluation processes indexed by EEG seem to be positively related to higher activation levels in the ventral striatum, indexed by fMRI, which are usually associated with reward processing. The current results, however, point towards a more general motivational mechanism processing salient stimuli during anticipation.
Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna, Austria. Electronic address: daniela.pfabigan@univie.ac.at.
Daniela M
DM
Pfabigan
Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna, Austria.
Eva-Maria
EM
Seidel
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Ronald
R
Sladky
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Andreas
A
Hahn
Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna, Austria.
Katharina
K
Paul
Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna, Austria.
Arvina
A
Grahl
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Martin
M
Küblböck
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Christoph
C
Kraus
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Allan
A
Hummer
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Georg S
GS
Kranz
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Christian
C
Windischberger
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Rupert
R
Lanzenberger
Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna, Austria.
Claus
C
Lamm
D000328:Adult; D059031:Anticipation, Psychological / Q000502:physiology; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D004569:Electroencephalography / Q000379:methods*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009042:Motivation / Q000502:physiology*; D015203:Reproducibility of Results; D012201:Reward; D012680:Sensitivity and Specificity; D066328:Ventral Striatum / Q000502:physiology*
Anticipation; EEG; Monetary incentive delay task; Motivation; Reward; fMRI