A roadmap to understanding toll pathway changes: an educational primer for use with "regulation of toll signaling and inflammation by β-arrestin and the SUMO protease Ulp1".
An article by Anjum et al. in the December 2013 issue of GENETICS can be used to illustrate reverse genetic manipulation in a model organism, targeted RNA interference, synergistic gene interaction, and biochemical regulation of gene expression using post-translational modification. This Primer provides background information, technical explanations of methods and genetic approaches from the study, an example approach for classroom use, and discussion questions to promote understanding of the research article.
Department of Biology and Chemistry, Upper Iowa University, Fayette, Iowa 52142.
Rebecca L
RL
Schmidt
D000818:Animals; D035843:Biomedical Research / Q000193:education*; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000276:immunology* / Q000378:metabolism; D004843:Epistasis, Genetic; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D023421:Models, Animal; D011499:Protein Processing, Post-Translational; D034622:RNA Interference; D059386:Reverse Genetics / Q000379:methods*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism
D029721:Drosophila Proteins; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors
Drosophila; SUMO; education; krz; placeholder; toll pathway