Conformation sequence recovery of a non-periodic object from a diffraction-before-destruction experiment.
Knowledge of the sequence of different conformational states of a protein molecule is key to better understanding its biological function. A diffraction pattern from a single conformational state can be captured with an ultrafast X-ray Free-Electron Laser (XFEL) before the target is completely annihilated by the radiation. In this paper, we report the first experimental demonstration of conformation sequence recovery using diffraction patterns from randomly ordered conformations of a non-periodic object using the dimensional reduction technique Isomap and coherent diffraction imaging.
Chun Hong
CH
Yoon
Miriam
M
Barthelmess
Richard J
RJ
Bean
Flavio
F
Capotondi
Richard A
RA
Kirian
Maya
M
Kiskinova
Emanuele
E
Pedersoli
Lorenzo
L
Raimondi
Francesco
F
Stellato
Fenglin
F
Wang
Henry N
HN
Chapman