Drug targeting using solid lipid nanoparticles.
The present review aims to show the features of solid lipid nanoparticles (SLNs) which are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Because of some unique features of SLNs such as their unique size dependent properties it offers possibility to develop new therapeutics. A common denominator of all these SLN-based platforms is to deliver drugs into specific tissues or cells in a pathological setting with minimal adverse effects on bystander cells. SLNs are capable to incorporate drugs into nanocarriers which lead to a new prototype in drug delivery which maybe used for drug targeting. Hence solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence attracted wide attention of researchers. This review presents a broad treatment of targeted solid lipid nanoparticles discussing their types such as antibody SLN, magnetic SLN, pH sensitive SLN and cationic SLN.
Larestan School of Medical Science, Larestan, Iran.
Elham
E
Rostami
Faculty of Chemistry, Nanoscience and Nanotechnology Research Center and Sensor and Biosensor Research Center, Razi University, P.O. Box 67149, Kermanshah, Iran. Electronic address: kashanian_s@yahoo.com.
Soheila
S
Kashanian
Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.
Abbas H
AH
Azandaryani
Larestan School of Medical Science, Larestan, Iran.
Hossain
H
Faramarzi
Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
Jafar Ezzati Nazhad
JE
Dolatabadi
Endocrine and Metabolism Research Center, Tehran University of Medical Sciences, P.O. Box 14395/1179, Tehran, Iran.
Kobra
K
Omidfar
D000906:Antibodies / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods*
D000906:Antibodies; D004337:Drug Carriers; D008055:Lipids
Antibody; Drug targeting; Magnetic SLN; Solid lipid nanoparticle; pH-sensitive