Cutting edge: The transcription factor Bob1 counteracts B cell activation and regulates miR-146a in B cells.
Mice lacking the lymphocyte-specific transcription factor Bob1 (also called OBF-1 or OCA-B) fail to generate germinal centers and a robust Ig response. We show that peripheral B cells in Bob1(-/-) mice bear characteristics of chronically activated or anergic-like B cells and identify the immunosuppressive microRNA-146a, together with other microRNAs, as novel transcriptional targets of Bob1. The inability to restrict B cell signaling could contribute to the immunodeficient phenotype of these mice and is consistent with an important role for Bob1 in suppressing B cell activation in vivo.
Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany;
John M
JM
Lindner
Hiroyuki
H
Kayo
Sebastian
S
Hedlund
Yoko
Y
Fukuda
Taro
T
Fukao
Peter J
PJ
Nielsen
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D008213:Lymphocyte Activation / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000235:genetics / Q000276:immunology*
D035683:MicroRNAs; C534190:Mirn146 microRNA, mouse; C490424:Pou2af1 protein, mouse; D015534:Trans-Activators