A dysmorphic newborn with petechiae and a 'Big Heart'.
A male fetus was noted to have an isolated pericardial effusion. At birth, he had dysmorphic features of Down syndrome and extensive petechiae. He was diagnosed to have transient myeloproliferative disorder. The large pericardial effusion and TMD spontaneously resolved. At 4 years of age, he was diagnosed with acute megakaryoblastic leukaemia, underwent chemotherapy and achieved complete remission.
Department of Paediatrics, National University Hospital, Singapore, Singapore.
Ling Zhi Bernice
LZ
Oh
Peng Mei Yvonne
PM
Ng
Thuan Chong
TC
Quah
D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications*; D005333:Fetus; D006801:Humans; D007231:Infant, Newborn; D007947:Leukemia, Megakaryoblastic, Acute / Q000209:etiology*; D007955:Leukemoid Reaction / Q000150:complications*; D008297:Male; D009196:Myeloproliferative Disorders / Q000150:complications*; D010490:Pericardial Effusion / Q000209:etiology*; D010496:Pericardium / Q000473:pathology*; D011693:Purpura / Q000209:etiology*