Cellular metabolism on T-cell development and function.
Cell metabolism is closely related to the host immunity in many respects. We herein briefly summarized the recent progress on the roles of cellular metabolism in T-cell development, homeostasis, differentiation and functions. Relatively quiescent naïve T cells only require energy for survival and migration, and they mainly metabolize glucose to carbon dioxide through oxidative phosphorylation. However, activated T cells engage in robust cell proliferation, produce of a range of effector molecules and migrate through peripheral tissues, so they utilizes glycolysis to convert glucose to lactate (termed aerobic glycolysis) to meet the significantly increased metabolic demands. Importantly, the differentiation of T-cell subsets and memory T cells (Tm) was also significantly shaped by distinct cellular metabolic pathways including glucose, amino acids (AA), fatty acids (FA), and others. Understanding the regulatory metabolic networks on immunity may offer new insights into the immune-related disorders and open novel potential therapies to prevent and treat immune diseases.
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Hui
H
Chen
Tao
T
Yang
Linnan
L
Zhu
Yong
Y
Zhao
D000596:Amino Acids / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D005227:Fatty Acids / Q000276:immunology / Q000378:metabolism; D005786:Gene Expression Regulation; D005947:Glucose / Q000276:immunology / Q000378:metabolism*; D006019:Glycolysis / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D010085:Oxidative Phosphorylation; D051880:Receptors, Notch / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000276:immunology; D060168:Thymocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology / Q000378:metabolism*
D000596:Amino Acids; D005227:Fatty Acids; D051880:Receptors, Notch; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D005947:Glucose
CD4+ T cells; aerobic glycolysis; glucose; immunity; mTOR; metabolism