Association of Ureaplasma urealyticum colonization with development of bronchopulmonary dysplasia: a systemic review and meta-analysis.
There is controversy regarding the roles of Ureaplasma urealyticum (U. urealyticum) colonization in the development of bronchopulmonary dysplasia (BPD). This study explored the association between U. urealyticum and bronchopulmonary dysplasia at 36 weeks post-menstrual age (BPD36). Studies published before December 31, 2013 were searched from Medline, Embase, Ovid, Web of Science, and Cochrane databases, with the terms "Ureaplasma urealyticum", "chronic lung disease", or "BPD36" used, and English language as a limit. The association between U. urealyticum colonization and BPD36 was analyzed with RevMan 4.2.10 software, using the odds ratio (OR) and relative risk (RR) for dichotomous variables. Out of the enrolled 81 studies, 11 investigated the BPD36 in total 1193 infants. Pooled studies showed no association between U. urealyticum colonization and subsequent development of BPD36, with the OR and RR being 1.03 (95% CI=0.78-1.37; P=0.84) and 1.01 (95% CI= 0.88-1.16, P=0.84), respectively. These findings indicated no association between U. urealyticum colonization and the development of BPD36.
Department of Stomatology, Huazhong University of Science and Technology, Wuhan, 430022, China.
Xiao-Dan
XD
Zheng
Department of Pediatric Surgery, Huazhong University of Science and Technology, Wuhan, 430022, China.
Dan
D
Li
Department of Pediatric Surgery, Huazhong University of Science and Technology, Wuhan, 430022, China.
De-Hua
DH
Yang
Department of Pediatric Surgery, Huazhong University of Science and Technology, Wuhan, 430022, China.
Xuan
X
Xiang
Department of Pediatric Surgery, Huazhong University of Science and Technology, Wuhan, 430022, China.
Hong
H
Mei
Department of Pediatric Surgery, Huazhong University of Science and Technology, Wuhan, 430022, China.
Jia-Rui
JR
Pu
Department of Pediatric Surgery, Huazhong University of Science and Technology, Wuhan, 430022, China.
Qiang-Song
QS
Tong
Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. ld_zheng@hotmail.com.
Li-Duan
LD
Zheng
D001997:Bronchopulmonary Dysplasia / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D016869:Ureaplasma Infections / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D016990:Ureaplasma urealyticum / Q000254:growth & development / Q000472:pathogenicity*