A new xanthone derivative from twigs of Garcinia nobilis.
Phytochemical investigation of the twigs of Garcinia nobilis led to the isolation of a new xanthone, named l-hydroxy-2,5-dimethoxyxanthone (1), together with 15 known compounds (2-16). The structures of the new and known compounds were established by means of spectroscopic methods and by comparison with previously reported data. The structure of compound 1 was confirmed by X-ray diffraction data. Compounds 1-16 were tested for their cytotoxic activity against human cervix carcinoma cell line KB-3-1. Compounds 5 and 11 showed moderate activity while others showed weak biological activity in these cytotoxicity assays. Compounds 4 and 9 were found to be inactive.
a Department of Organic Chemistry , Faculty of Science, University of Yaoundé I , P.O. Box 812, Yaoundé , Cameroon.
Hugues
H
Fouotsa
Simplice J N
SJ
Tatsimo
Beate
B
Neumann
Carmela
C
Michalek
Celine Djama
CD
Mbazoa
Augustin Ephrem
AE
Nkengfack
Norbert
N
Sewald
Alain Meli
AM
Lannang
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002163:Cameroon; D004354:Drug Screening Assays, Antitumor; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones; C000592501:l-hydroxy-2,5-dimethoxyxanthone
Garcinia nobilis; Guttiferae; cytotoxicity; xanthone