Structure-function correlations in glaucoma using matrix and standard automated perimetry versus time-domain and spectral-domain OCT devices.
OBJECTIVE
We examined the structure-function relationship between two perimetric tests, the frequency doubling technology (FDT) matrix and standard automated perimetry (SAP), and two optical coherence tomography (OCT) devices (time-domain and spectral-domain).


METHODS
This cross-sectional study included 97 eyes from 29 healthy individuals, and 68 individuals with early, moderate, or advanced primary open-angle glaucoma. The correlations between overall and sectorial parameters of retinal nerve fiber layer thickness (RNFL) measured with Stratus and Spectralis OCT, and the visual field sensitivity obtained with FDT matrix and SAP were assessed. The relationship also was evaluated using a previously described linear model.


RESULTS
The correlation coefficients for the threshold sensitivity measured with SAP and Stratus OCT ranged from 0.44 to 0.79, and those for Spectralis OCT ranged from 0.30 to 0.75. Regarding FDT matrix, the correlation ranged from 0.40 to 0.79 with Stratus OCT and from 0.39 to 0.79 with Spectralis OCT. Stronger correlations were found in the overall measurements and the arcuate sectors for both visual fields and OCT devices. A linear relationship was observed between FDT matrix sensitivity and the OCT devices. The previously described linear model fit the data from SAP and the OCT devices well, particularly in the inferotemporal sector.


CONCLUSIONS
The FDT matrix and SAP visual sensitivities were related strongly to the RNFL thickness measured with the Stratus and Spectralis OCT devices, particularly in the overall and arcuate sectors.
Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil.
Luciano Moreira
LM
Pinto
Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil.
Elaine Fiod
EF
Costa
Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil.
Luiz Alberto S
LA
Melo
Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil.
Paula Blasco
PB
Gross
Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil.
Eduardo Toshio
ET
Sato
Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil.
Andrea Pereira
AP
Almeida
Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil.
Andre
A
Maia
Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil.
Augusto
A
Paranhos
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D012684:Sensory Thresholds / Q000502:physiology; D041623:Tomography, Optical Coherence / Q000379:methods*; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields / Q000502:physiology*
automated perimetry; glaucoma posterior segment; optical coherence tomography