[Early maternal deprivation decreases the immunological function of F1 generation offspring in mice].
OBJECTIVE
To explore the changes of immunological function in F1 generation offspring after suffering early maternal deprivation.


METHODS
Using Wistar rats, the maternal deprivation models were established according to our previous study. Their F1 generation offspring were enrolled for this study. The mass and indexes of spleen and thymus were measured. The phagocytosis assay was used to detect the phagocytic function of peritoneal macrophages. The proliferation of T lymphocytes was detected by MTT assay. ELISA was employed to determine the IL-2 level in serum.


RESULTS
The maternal deprivation decreased the mass and indexes of spleen and thymus of their offspring. The phagocytic function of macrophage, proliferation of T lymphocytes and IL-2 level in serum of F1 generation offspring were also reduced.


CONCLUSIONS
The immunological function declines in F1 generation offspring after suffering early maternal deprivation in mice.
School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Fei
F
Xiao
First Affiliated Hospital, Jiamusi University, Jiamusi 154007, China.
Chaoyang
C
Liu
School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Tao
T
Zhang
School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Guozhong
G
Yu
First Affiliated Hospital, Jiamusi University, Jiamusi 154007, China.
Guoli
G
Cui
D000818:Animals; D049109:Cell Proliferation; D005260:Female; D007109:Immunity; D007376:Interleukin-2 / Q000097:blood; D017737:Macrophages, Peritoneal / Q000276:immunology; D008297:Male; D008426:Maternal Deprivation; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology
D007376:Interleukin-2