Role of noncoding RNAs in the regulation of P-TEFb availability and enzymatic activity.
P-TEFb is a transcriptional factor that specifically regulates the elongation step of RNA polymerase II-dependent transcription and its activity strictly required for Human Immunodeficiency Virus (HIV) infection and during cardiac differentiation. P-TEFb role has emerged as a crucial regulator of transcription elongation and its activity found finely tuned in vivo at transcriptional level as well as posttranscriptionally by dynamic association with different multisubunit molecular particles. Both physiological and pathological cellular signals rapidly converge on P-TEFb regulation by modifying expression and activity of the complex to allow cells to properly respond to different stimuli. In this review we will give a panoramic view on P-TEFb regulation by noncoding RNAs in both physiological and pathological conditions.
Department of Biology, University of Naples Federico II, Naples, Italy.
Giuliana
0000-0002-1637-6016
G
Napolitano
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Italy.
Luigi
L
Lania
Department of Biology, University of Naples Federico II, Naples, Italy.
Barbara
B
Majello
D000818:Animals; D005786:Gene Expression Regulation; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism; D015497:HIV-1 / Q000235:genetics / Q000378:metabolism; D006801:Humans; D042925:Positive Transcriptional Elongation Factor B / Q000235:genetics / Q000378:metabolism*; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*; D061805:Transcription Elongation, Genetic
D022661:RNA, Untranslated; D042925:Positive Transcriptional Elongation Factor B; D012319:RNA Polymerase II