Correlation of fibroblast growth factor 21 serum levels with metabolic parameters in Japanese subjects.
OBJECTIVE
Since serum level of fibroblast growth factor 21 (FGF21) has been implicated as a potential biomarker for the early detection of the metabolic syndrome and type 2 diabetes, we examined how FGF21 serum levels are correlated with metabolic parameters in Japanese subjects.


METHODS
FGF21 levels were analyzed by enzyme-linked immunosorbent assays. Spearman's correlation and multiple stepwise regression analyses were used to examine the relationship between serum FGF21 and other factors. A Mann-Whitney U test was performed between the normal and high groups for triglycerides and systolic blood pressure (BP) respectively.


RESULTS
By univariate correlation analysis, serum FGF21 levels were significantly associated with triglyceride levels, systolic BP, diastolic BP, pulse pressure, body mass index (BMI), age, fasting plasma glucose (FPG) levels, and total cholesterol levels. Multiple regression analysis (adjusted for age, gender, and BMI) showed that serum FGF21 levels were independently and significantly associated with triglyceride levels and systolic BP. Serum FGF21 levels were significantly higher in subjects with high triglyceride levels and high systolic BP compared with those who had normal triglyceride levels and normal systolic BP respectively.


CONCLUSIONS
This study found that FGF21 levels might be a biomarker for some metabolic disorders associated with metabolic syndrome.
Department of Life Systems, Institute of Technology and Science, the University of Tokushima.
Qing-Ri
QR
Jin
Yukiko
Y
Bando
Katsuyuki
K
Miyawaki
Yosuke
Y
Shikama
Chisato
C
Kosugi
Nanako
N
Aki
Makoto
M
Funaki
Sumihare
S
Noji
D000328:Adult; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism* / Q000503:physiopathology*; D008875:Middle Aged; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D014280:Triglycerides; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors