[Morpho functional state of the peripheral organs of the immune system in rats after the hypokinesia and in the period of rehabilitation].
Using the quantitative methods, the remodeling of the cytoarchitectonics of the morpho-functional zones in the grouped lymphoid nodules (GLN) or Peyer's patches and in the mesenteric lymph nodes (MLN) were studied in 30 rats after 30-day-long exposure to hypokinesia and during the period of rehabilitation (30 days after hypokinesia discontinuation). It was found that following the hypokinesia the germinal centers in lymphoid nodules in GLN retained the lymphocytopoiesis, while in the internodular zone the proportion of immature cells was increased and plasma cells appeared. In the similar structural zones of MLN, the complete suppression of lymphocytopoiesis and T-cell maturation was noted. During the rehabilitation period, the cytoarchitectonic indexes recovery was more pronounced in GLN than in MLN. However, the quantitative parameters of their cellular composition did not reach the values found in the group of intact of animals.
D E
DE
Grigorenko
G G
GG
Aminova
K A
KA
Vasianina
D000818:Animals; D018476:Hypokinesia / Q000473:pathology*; D007107:Immune System; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure*; D038041:Lymphopoiesis; D008643:Mesentery / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure*; D010581:Peyer's Patches / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D051381:Rats; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000648:ultrastructure