Antioxidant and anticancer constituents from the leaves of Liriodendron tulipifera.
Sixteen compounds were extracted and purified from the leaves of Liriodendron tulipifera. These compounds include aporphines, oxoaporphine, coumarin, sesquiterpene lactone, benzenoids, cyclitol and steroids. (+)-Norstephalagine (2) (an aporphine) and scopoletin (8) (a coumarin) were isolated from Liriodendron tulipifera leaves from the first time. The identified compounds were screened for their antiradical scavenging, metal chelating and ferric reducing power activities. The results have showed that these compounds have antioxidative activity. The study has also examined the chemopreventive property of the isolated compounds against human melanoma cells A375. The results shown that (-)-anonaine (1), (-)-liridinine (3), (+)-lirinidine (6), lysicamine (7) and epitulipinolide diepoxide (9) significantly inhibited the proliferation of melanoma cells. These results revealed that these compounds have antioxidative activity and chemopreventive activity in skin melanoma cells.
Department of Health Beauty, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan. mt069@fy.edu.tw.
Ya-Fei
YF
Kang
Tzu Hui Institute of Technology, Pingtung County 92641, Taiwan. beagleliu@gmail.com.
Chi-Ming
CM
Liu
Department of Health Beauty, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan. beagleliu@gmail.com.
Chiu-Li
CL
Kao
Department of Nutrition and Health Science, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan. xx377@fy.edu.tw.
Chung-Yi
CY
Chen
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001060:Aporphines / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004149:Dioxoles / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D031567:Liriodendron / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D012603:Scopoletin / Q000302:isolation & purification / Q000494:pharmacology
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D001060:Aporphines; D004149:Dioxoles; D010936:Plant Extracts; C069090:lysicamine; C098138:anonaine; C054613:lirinidine; C064685:norstephalagine; D012603:Scopoletin