Stem cell-based therapies for ischemic stroke.
In recent years, stem cell-based approaches have attracted more attention from scientists and clinicians due to their possible therapeutical effect on stroke. Animal studies have demonstrated that the beneficial effects of stem cells including embryonic stem cells (ESCs), inducible pluripotent stem cells (iPSCs), neural stem cells (NSCs), and mesenchymal stem cell (MSCs) might be due to cell replacement, neuroprotection, endogenous neurogenesis, angiogenesis, and modulation on inflammation and immune response. Although several clinical studies have shown the high efficiency and safety of stem cell in stroke management, mainly MSCs, some issues regarding to cell homing, survival, tracking, safety, and optimal cell transplantation protocol, such as cell dose and time window, should be addressed. Undoubtably, stem cell-based gene therapy represents a novel potential therapeutic strategy for stroke in future.
Department of Neurology, No.324 Hospital of PLA, Chongqing 400020, China.
Lei
L
Hao
Department of Chemical Defense and Toxicology, Institute of Toxicology, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
Zhongmin
Z
Zou
Department of Neurology, No.324 Hospital of PLA, Chongqing 400020, China.
Hong
H
Tian
Department of Neurology, No.324 Hospital of PLA, Chongqing 400020, China.
Yubo
Y
Zhang
Department of Neurology, No.324 Hospital of PLA, Chongqing 400020, China.
Huchuan
H
Zhou
Department of Neurology, No.324 Hospital of PLA, Chongqing 400020, China.
Lei
L
Liu
D000818:Animals; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D007511:Ischemia / Q000473:pathology / Q000628:therapy*; D059630:Mesenchymal Stem Cells / Q000166:cytology; D058953:Neural Stem Cells / Q000166:cytology; D055495:Neurogenesis; D033581:Stem Cell Transplantation / Q000379:methods*; D020521:Stroke / Q000473:pathology / Q000628:therapy*