Interleukin-10 inhibits bone resorption: a potential therapeutic strategy in periodontitis and other bone loss diseases.
Periodontitis and other bone loss diseases, decreasing bone volume and strength, have a significant impact on millions of people with the risk of tooth loss and bone fracture. The integrity and strength of bone are maintained through the balance between bone resorption and bone formation by osteoclasts and osteoblasts, respectively, so the loss of bone results from the disruption of such balance due to increased resorption or/and decreased formation of bone. The goal of therapies for diseases of bone loss is to reduce bone loss, improve bone formation, and then keep healthy bone density. Current therapies have mostly relied on long-term medication, exercise, anti-inflammatory therapies, and changing of the life style. However there are some limitations for some patients in the effective treatments for bone loss diseases because of the complexity of bone loss. Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine, and recent studies have indicated that IL-10 can contribute to the maintenance of bone mass through inhibition of osteoclastic bone resorption and regulation of osteoblastic bone formation. This paper will provide a brief overview of the role of IL-10 in bone loss diseases and discuss the possibility of IL-10 adoption in therapy of bone loss diseases therapy.
Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China.
Qian
0000-0003-0412-5014
Q
Zhang
Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China.
Bin
0000-0001-8690-1835
B
Chen
Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China.
Fuhua
0000-0001-5632-9487
F
Yan
School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiaozhong Road, Fuzhou, Fujian 350002, China.
Jianbin
J
Guo
School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiaozhong Road, Fuzhou, Fujian 350002, China.
Xiaofeng
X
Zhu
School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiaozhong Road, Fuzhou, Fujian 350002, China.
Shouzhi
S
Ma
School of Life and Environmental Science, Waurn Ponds Campus, Deakin University, 75 Pigdons Road, Geelong, VIC 3216, Australia.
Wenrong
W
Yang
D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D016753:Interleukin-10 / Q000494:pharmacology / Q000627:therapeutic use*; D010518:Periodontitis / Q000188:drug therapy*
D016753:Interleukin-10