Evaluation of green pepper (Capsicum annuum L.) juice on the weight gain and changes in lipid profile in C57BL/6 mice fed a high-fat diet.
BACKGROUND
Capsicum pepper (green pepper, Capsicum annuum L.), a natural product available in many countries, is considered to be a food additive, with healthful or medical applications. The aim of this study was to evaluate green pepper juice for its potential to reduce weight gain and to determine its effects on lipid profiles in C57BL/6 mice fed a high-fat diet.


RESULTS
Mice given a high-fat diet with green pepper juice gained significantly less weight and showed a significant decrease in serum triglycerides, total cholesterol, low density lipoproteins, and alanine aminotransferase compared to mice given only a high-fat diet (P < 0.05). Systolic and diastolic blood pressure, heart rate, and blood glucose levels (determined by using the intraperitoneal glucose tolerance test) in mice administered green pepper juice were similar to those in mice in the control group. In addition, abdominal fat volume (subcutaneous and visceral), which was quantified by using 4.7 T magnetic resonance imaging, including multi-slice spin-echo T2-weighted images, in mice administered a high-fat diet with green pepper juice tended to decrease compared to the fat volume of mice administered only a high-fat diet.


CONCLUSIONS
These results suggest that green pepper juice, as a drink, may possibly be helpful in reducing weight gain by regulating the levels of serum lipids.
Institute for Metabolic disease, Wonkwang University, Iksan, 344-2, Republic of Korea; Graduate School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Republic of Korea.
Na-Hyung
NH
Kim
Seong Hoon
SH
Park
D050153:Abdominal Fat / Q000033:anatomy & histology; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001628:Beverages; D002212:Capsicum / Q000737:chemistry; D002784:Cholesterol / Q000097:blood; D004032:Diet; D059305:Diet, High-Fat; D006293:Health Promotion; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain
D008055:Lipids; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol; D000410:Alanine Transaminase
abdominal fat volume; body weight; green pepper juice; non-invasive 4.7 T magnetic resonance imaging; triglycerides