Indocyanine green angiography for the diagnosis of peripheral arterial disease with isolated infrapopliteal lesions.
BACKGROUND
In this study, we evaluated the accuracy of the indocyanine green angiography (ICGA) test to diagnose peripheral arterial disease (PAD) with isolated infrapopliteal lesions.


METHODS
This study was undertaken from a retrospective review of PAD patients with isolated infrapopliteal lesions who underwent ICGA between November 2012 and July 2013. We calculated the ICGA parameters while comparing the findings with the ankle-brachial index (ABI) and toe-brachial index (TBI) in patients with infrapopliteal lesions.


RESULTS
Twenty-three limbs with isolated infrapopliteal lesions in 14 PAD patients and 15 limbs without arterial lesions in 9 control patients were examined using ABI, TBI, and ICGA. The Td 90% (the time elapsed from the maximum intensity to 90% of the maximum intensity) correlated most significantly with the ABI value. A cutoff value of Td 90% >25 sec also significantly correlated with the presence of PAD (sensitivity, 82.6%).


CONCLUSIONS
ICGA might therefore be useful for assessing the peripheral perfusion quantitatively, even in PAD patients with isolated infrapopliteal lesions. The use of Td 90% on ICGA may also be effective for accurately estimating the presence of PAD.
Division of Vascular and Endovascular Surgery, Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: igari.srg1@tmd.ac.jp.
Kimihiro
K
Igari
Division of Vascular and Endovascular Surgery, Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Toshifumi
T
Kudo
Division of Vascular and Endovascular Surgery, Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Hidetoshi
H
Uchiyama
Division of Vascular and Endovascular Surgery, Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Takahiro
T
Toyofuku
Division of Vascular and Endovascular Surgery, Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Yoshinori
Y
Inoue
D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography / Q000379:methods*; D055109:Ankle Brachial Index; D005456:Fluorescent Dyes; D006439:Hemodynamics; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging / Q000379:methods*; D058729:Peripheral Arterial Disease / Q000175:diagnosis* / Q000503:physiopathology; D011150:Popliteal Artery / Q000503:physiopathology; D011237:Predictive Value of Tests; D012039:Regional Blood Flow; D012189:Retrospective Studies; D013997:Time Factors
D005456:Fluorescent Dyes; D007208:Indocyanine Green