Diffuse large B-cell lymphoma of stomach presenting with paraneoplastic cerebellar degeneration syndrome.
Paraneoplastic syndromes are most often diagnosed in the setting of a known malignancy. It is not uncommon for a paraneoplastic disorder to develop before a cancer is identified. While syndrome of cerebellar degeneration has been identified as a paraneoplastic manifestation of Hodgkin's lymphoma, thymoma, lung and breast cancer, ovarian and testicular tumors, melanoma, renal cell carcinoma, follicular lymphoma and adenocarcinoma of stomach, its association with non-Hodgkin's lymphoma and particularly diffuse large B-cell lymphoma has not been established previously. This case report describes the primary presentation with signs of paraneoplastic cerebellar degeneration as the only manifestation of an underlying diffuse large B-cell lymphoma making it the first of its kind to be formally reported. Furthermore, it also includes the identification of associated paraneoplastic antibodies for this particular syndrome.
Department of Medicine, Khan Research Laboratories (KRL) Hospital, Islamabad.
Ali Zohair
AZ
Nomani
Department of Medicine, Khan Research Laboratories (KRL) Hospital, Islamabad.
Marina
M
Wazir
Department of Medicine, Khan Research Laboratories (KRL) Hospital, Islamabad.
Saba Binte
SB
Kashmir
Department of Medicine, Khan Research Laboratories (KRL) Hospital, Islamabad.
Muhammad Saleem
MS
Qureshi
D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003520:Cyclophosphamide; D004317:Doxorubicin; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000473:pathology*; D008875:Middle Aged; D020362:Paraneoplastic Cerebellar Degeneration / Q000473:pathology*; D011241:Prednisone; D000069283:Rituximab; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014750:Vincristine
D058846:Antibodies, Monoclonal, Murine-Derived; C571759:R-CHOP protocol; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone