STIM1 for stimulation of phagocyte NADPH oxidase.
In this issue of Blood, Zhang et al show that mice lacking the stromal-interacting molecule 1 (STIM1) gene in bone marrow cells are more susceptible to bacterial infection but are resistant to ischemia/reperfusion injury because of defective activation of phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.
SHANGHAI JIAO TONG UNIVERSITY;
Richard D
RD
Ye
D000818:Animals; D015220:Calcium Channels; D007109:Immunity / Q000235:genetics*; D007249:Inflammation / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000502:physiology*; D010088:Oxidoreductases / Q000378:metabolism*; D010586:Phagocytes / Q000201:enzymology*; D000071737:Stromal Interaction Molecule 1
D015220:Calcium Channels; D008562:Membrane Glycoproteins; C100757:Stim1 protein, mouse; D000071737:Stromal Interaction Molecule 1; D010088:Oxidoreductases