Imaging Oxygen Metabolism In Acute Stroke Using MRI.
The ability to image the ischemic penumbra during hyper-acute stroke promises to identify patients who may benefit from treatment intervention beyond population-defined therapeutic time windows. MR blood oxygenation level dependent (BOLD) contrast imaging has been explored in ischemic stroke. This review provides an overview of several BOLD-based methods, including susceptibility weighted imaging (SWI), R2, R2*, R2', R2* under oxygen challenge, MR_OEF and MROMI approaches to assess cerebral oxygen metabolism in ischemic stroke. We will review the underlying pathophysiological basis of the imaging approaches, followed by a brief introduction of BOLD contrast. Finally, we will discuss the applications of the BOLD approaches in patients with ischemic stroke. BOLD-based methods hold promise for imaging tissue oxygenation during acute ischemia. Further technical refinement and validation studies in stroke patients against positron emission tomography (PET) measurements are needed.
Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill.
Hongyu
H
An
Department of Neurology, Washington University School of Medicine, St. Louis, MO.
Andria L
AL
Ford
Department of Radiology, Washington University School of Medicine, St. Louis, MO.
Katie D
KD
Vo
Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill.
Qingwei
Q
Liu
Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill.
Yasheng
Y
Chen
Department of Neurology, Washington University School of Medicine, St. Louis, MO ; Department of Radiology, Washington University School of Medicine, St. Louis, MO.
Jin-Moo
JM
Lee
Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill.
Weili
W
Lin
BOLD; MRI; cerebral blood flow; ischemia; oxygen extraction fraction; oxygen metabolism