Invadopodia formation in blood clots: Not so SLUGgish after all.
Blood clotting specifically supports the metastatic dissemination of malignant cells to the lung. We have recently demonstrated that 2 tumor types that are prone to form lung metastases, renal cell carcinoma and soft tissue sarcoma, share specific adhesive mechanisms that support the invasion and colonization of blood clots in the pulmonary vasculature.
Department of Urology; University of Pittsburgh School of Medicine; Shadyside Medical Center; Pittsburgh, PA USA.
Lynn M
LM
Knowles
Department of Urology; University of Pittsburgh School of Medicine; Shadyside Medical Center; Pittsburgh, PA USA ; Prostate and Urological Cancers Program; University of Pittsburgh Cancer Institute; Pittsburgh, PA USA.
Jodi K
JK
Maranchie
Department of Urology; University of Pittsburgh School of Medicine; Shadyside Medical Center; Pittsburgh, PA USA ; Prostate and Urological Cancers Program; University of Pittsburgh Cancer Institute; Pittsburgh, PA USA.
Jan
J
Pilch
SLUG; fibrin; fibronectin; integrin αvβ3; metastasis