Amiodarone-induced SIADH: two cases report.
Amiodarone-induced SIADH is a rare but serious side effect of this drug. We report two cases of mild hyponatremia, observed in the last five years, and discuss the role played by age, sex and dose of amiodarone as well as the influence that this molecule may have on aquaporin-2 water channel expression in the renal collecting ducts.
Michele
M
Iovino
Nicola
N
Iovine
Antonio
A
Petrosino
Brunella
B
Licchelli
Vito A
VA
Giagulli
Massimo
M
Iacoviello
Edoardo
E
Guastamacchia
Endocrinology and Metabolic Diseases, Eboli Hospital, Salerno, Italy. micheleiovino06@tin.it.
Vincenzo
V
Triggiani
D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D008297:Male
D000638:Amiodarone