Synthesis, characterization, biological activity of binuclear Co(II), Cu(II) and mononuclear Ni(II) complexes of bulky multi-dentate thiosemicarbazide.
The chelation behavior of 9,10-dihydro-9,10-ethanoanthracene-11,12-dicarbonyl) bis (N-ethylhydrazine-1-carbothioamide) (H6ETS)(1) towards Co(2+), Ni(2+)and Cu(2+) have been studied. The spectral data revealed that the ligand acts as a bi- and/or mono-negative multi-dentate. The isolated Ni(II) and Cu(II) complexes are square-planar while the Co(II) is tetrahedral. EPR spectrum of Cu(II) complex confirmed simulated an axial spin-Hamiltonian exhibiting a four-line pattern with nitrogen super-hyperfine couplings originating from imine hydrazinic nitrogen atoms and possess a significant amount of tetrahedral distortion leading to a pseudo-square-planar geometry with unpaired electron has d(x(2)-y(2)) ground state. Also, the thermal behavior and kinetic parameters were determined. Furthermore, the title compounds were investigated for their antibacterial activity using inhibition zone diameter and for DNA degradation, superoxide-scavenging activity as well as hydroxyl radicals that generated by the oxidation of cytochrome c in L-ascorbic acid/CuSO4-cytochrome c system.
Department of Chemistry, Faculty of Science, Mansoura University, P.O. Box 70, Mansoura 35566, Egypt. Electronic address: olaelgammal@yahoo.com.
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El-Gammal
Department of Chemistry, Faculty of Science, Mansoura University, P.O. Box 70, Mansoura 35566, Egypt.
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Abd Al-Gader
Department of Chemistry, Faculty of Science, Mansoura University, P.O. Box 70, Mansoura 35566, Egypt; Department of Chemistry, Faculty of Science, Kuwait University, Kuwait.
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El-Asmy
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001205:Ascorbic Acid / Q000737:chemistry; D001419:Bacteria / Q000254:growth & development; D001426:Bacterial Proteins / Q000737:chemistry; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003035:Cobalt / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D019327:Copper Sulfate / Q000737:chemistry; D045304:Cytochromes c / Q000737:chemistry; D004269:DNA, Bacterial / Q000737:chemistry; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction / Q000187:drug effects; D012663:Semicarbazides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002614:Chelating Agents; D004269:DNA, Bacterial; D012663:Semicarbazides; D003035:Cobalt; D003300:Copper; D009532:Nickel; D045304:Cytochromes c; D019327:Copper Sulfate; D001205:Ascorbic Acid
Antibacterial; Hydroxyl radical and superoxide dismutase; Molecular modeling; Multidentate thiosemicarbazide; Thermal