Expression of glycolysis-related proteins in solid papillary carcinoma of the breast according to basement membrane status.
OBJECTIVE
The aim of this study was to investigate the differences of expression in glycolysis-related proteins such as Glut-1, carbonic anhydrase (CA) IX, and monocarboxylate transporter (MCT) 4 according to the myoepithelial cell (MEC) and basement membrane (BM) status in solid papillary carcinoma (SPC) of the breast.


METHODS
Immunohistochemical evaluation of Glut-1, CAIX, and MCT4, as well as p63 and type IV collagen, were performed on 23 SPC cases.


RESULTS
Six and nine cases of SPC showed the presence and absence of myoepithelial cells, respectively, and eight cases belonged to the borderline status (p63-positive MEC on some areas of the outer tumor surface but not in others). BM was partially or completely absent in 14 cases and present in nine cases. SPC lacking BM more frequently showed high expression of CAIX than SPC with BM (p=0.037).


CONCLUSIONS
In SPC of the breast, a strong expression of CAIX seems to be associated with an increasing degree of loss of BM, which can be interpreted as BM degradation due to the induction of extracellular acidity with increasing expression of CAIX.
Department of Pathology, Ajou University College of Medicine, Suwon, Korea.
Ji Eun
JE
Kwon
Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Woo-Hee
WH
Jung
Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Ja Seung
JS
Koo
D000328:Adult; D000368:Aged; D001485:Basement Membrane / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism*; D002291:Carcinoma, Papillary / Q000378:metabolism*; D027342:Excitatory Amino Acid Transporter 2 / Q000378:metabolism; D005260:Female; D006019:Glycolysis; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism; D009124:Muscle Proteins / Q000378:metabolism
D014408:Biomarkers, Tumor; D027342:Excitatory Amino Acid Transporter 2; D027501:Monocarboxylic Acid Transporters; D009124:Muscle Proteins; C406962:SLC16A4 protein, human
Basement membrane; breast; metabolism; myoepithelial cell; solid papillary carcinoma