COX-2 polymorphisms -765G→C and -1195A→G and hepatocellular carcinoma risk.
Cyclooxygenase-2 (COX-2) is overexpressed in hepatocellular carcinoma (HCC) and considered to play a role in hepatic carcinogenesis. Our aim was to examine the associations between polymorphisms in COX-2 -765G→C and -1195A→G and risk of HCC. We conducted a case-control study including 120 patients with HCC and 130 age- and gender-matched controls. Genotypes of the COX-2 polymorphisms -765G→C and -1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism. No significant difference was observed in the genotype distribution of the -765G→C polymorphism between patients and controls. The -1195AA genotype was associated with an increased risk of developing HCC (OR, 2.5; 95%CI, 1.18-5.37). The A allele was present significantly more often in HCC patients (OR 1.5; 95%CI, 1.05-2.14). In conclusion, our results demonstrated that the -1195AA genotype and A allele have an important role in HCC risk in Egyptian patients.
Department of Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Aml F
AF
Gharib
Department of Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt; Department of Biochemistry, Faculty of Medicine, Taif University, Al Taif, Saudi Arabia. Electronic address: rehab_atta@yahoo.com.
Rehab A
RA
Karam
Department of Surgery, Faculty of Medicine, Taif University, Al Taif, Saudi Arabia; Department of Surgery, Benha Teaching Hospital, Benha, Egypt.
Tamer M
TM
Abd El Rahman
Department of Oncology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Wael H
WH
Elsawy
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology* / Q000235:genetics*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D004534:Egypt / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human
Cyclooxygenase-2 gene; Hepatocellular carcinoma; Single nucleotide polymorphisms