Metabolism goes viral.
Viral and cellular oncogenes converge in targeting critical protein interaction networks to reprogram the cellular DNA and protein replication machinery for pathological replication. In this issue, Thai et al. (2014) show that adenovirus E4ORF1 activates MYC glycolytic targets to induce a Warburg-like effect that converts glucose into nucleotides for viral replication.
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA.
Shigeki J
SJ
Miyake-Stoner
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA. Electronic address: oshea@salk.edu.
Clodagh C
CC
O'Shea
D017504:Adenovirus E4 Proteins / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D008954:Models, Biological; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D014779:Virus Replication / Q000502:physiology*
D017504:Adenovirus E4 Proteins; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D005947:Glucose