Gallbladder cancer in Chile: Pathologic characteristics of survival and prognostic factors: analysis of 1,366 cases.
OBJECTIVE
To explore gallbladder cancer (GBC), the second leading cause of cancer-related death in women in Chile.


METHODS
Analysis of macroscopic and microscopic variables, morphometry, and survival in 1,366 patients with GBC.


RESULTS
Patients comprised 1,138 women and 228 men; diagnoses included 213 (15.6%) cases of mucosal carcinoma, 132 (9.7%) cases of muscular carcinoma, 316 (23.1%) cases of subserosal carcinoma, 382 (28.0%) cases of serosal carcinoma, and 323 (23.6%) cases beyond the serosa. Women older than 55 years with a gallbladder length greater than 9.5 cm had a five-times-greater relative risk of cancer. Those with a gallbladder wall thickness less than 7 mm had a better 5-year survival rate than those with a gallbladder wall thickness greater than 10 mm (P = .0001). Patients who had cholesterolosis of the gallbladder had 9.2 times less probability of having cancer. The infiltration level of the gallbladder wall was the most important independent prognostic factor (P < .001), followed by differentiation and lymphatic involvement (P < .001 and P = .05, respectively). Vascular infiltration had a mortality rate of 100%.


CONCLUSIONS
Morphologic features are strongly associated with the prognosis of GBC and must be taken into consideration when supplementary treatment is recommended.
Avenida Del Valle Norte 857, Oficina 102, Huechuraba Santiago, 8580702, Chile; e-mail: ivanroaesterio@gmail.com.
Iván
I
Roa
Gilda
G
Ibacache
Sergio
S
Muñoz
Xabier
X
de Aretxabala
D000328:Adult; D000368:Aged; D002677:Chile / Q000453:epidemiology; D002763:Cholecystectomy / Q000379:methods; D005260:Female; D005704:Gallbladder / Q000473:pathology*; D005706:Gallbladder Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012737:Sex Factors
Factor; Gallbladder; Prognostic; Survival