The neurologic profile of children and adolescents with inflammatory bowel disease.
In recent years, there has been an increasing incidence of inflammatory bowel disease in children and adolescents. Neurologic involvement has been mainly reported in adults, and information in pediatrics is based primarily on individual case reports. In this study, we explored the prevalence and spectrum of neurologic manifestations of 50 children with inflammatory bowel disease in comparison to healthy controls. Based on clinical reports and neurologic evaluation, 34 patients (68%) exhibited neurologic manifestations compared with 10 children (23.8%) in the control group (P < .001). The main symptoms associated with inflammatory bowel disease in comparison to the control subjects were headache: 46% vs 3% (P < 0.001), dizziness: 26% vs none (P < .001), hypotonia: 10% vs none (P = .06), attention-deficit hyperactivity disorder (ADHD): 28% vs 7.1% (P < .001), tics and sensory complaints: 16% vs 2.4% (P = .036). Seizures and neuropsychiatric disorders were less characteristic. A larger-scale prospective study is required to further clarify this association.
The Department of Pediatrics, Carmel Medical Center, Haifa, Israel orlyben20@hotmail.com.
Orly
O
Ben-Or
The Department of Pediatrics, Carmel Medical Center, Haifa, Israel The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Nathanel
N
Zelnik
The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel The Pediatric Gastroenterology Unit, Rambam Medical Center, Haifa, Israel.
Ron
R
Shaoul
Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Haifa, Israel.
Avi
A
Pacht
The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Haifa, Israel.
Aaron
A
Lerner
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology* / Q000503:physiopathology*; D007557:Israel / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D011795:Surveys and Questionnaires; D055815:Young Adult
attention-deficit hyperactivity disorder (ADHD); headache; inflammatory bowel disease; neurologic manifestations