Ridge preservation using demineralized bone matrix gel with recombinant human bone morphogenetic protein-2 after tooth extraction: a randomized controlled clinical trial.
OBJECTIVE
The aim of the present randomized controlled trial was to determine the safety and efficacy of injectable demineralized bone matrix (DBM) gel combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) on alveolar ridge preservation after tooth extraction.


METHODS
A total of 69 patients were randomly assigned to either a test group (n = 35) or a control group (n = 34). In the test group, DBM, together with rhBMP-2 (0.05 mg/mL; rhBMP-2/DBM) was transplanted into the extraction sockets. The control group received DBM alone. The safety of rhBMP-2/DBM was evaluated by oral examination, serum chemistry, and hematologic examination. The radiographic changes in alveolar bone height and width were measured using computed tomography scans performed immediately after transplant and again 3 months thereafter.


RESULTS
Healing was uneventful in all subjects, with no anticipated adverse events and no clinically significant changes in the serum chemistry and hematologic findings. No meaningful immune response was found among the study groups. No significant difference was found in the radiographic changes of alveolar bone height and width (P > .05).


CONCLUSIONS
This new injectable biomaterial can be used easily and safely in clinical applications.
Resident, Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
Yu-Jin
YJ
Kim
Professor, Department of Prosthodontics, Institute for Clinical Dental Research, Korea University Guro Hospital, Korea University, Seoul, Korea.
Jeong-Yol
JY
Lee
Resident, Department of Prosthodontics, Institute for Clinical Dental Research, Korea University Guro Hospital, Korea University, Seoul, Korea.
Jong-Eun
JE
Kim
Clinical Research Assistant Professor, Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
Jung-Chul
JC
Park
Professor, Department of Prosthodontics, Institute for Clinical Dental Research, Korea University Guro Hospital, Korea University, Seoul, Korea.
Sang-Wan
SW
Shin
Professor, Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea. Electronic address: kscho@yuhs.ac.
Kyoo-Sung
KS
Cho
D000328:Adult; D016301:Alveolar Bone Loss / Q000517:prevention & control*; D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000601:surgery*; D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D016037:Single-Blind Method; D014057:Tomography, X-Ray Computed; D014081:Tooth Extraction / Q000009:adverse effects*; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000627:therapeutic use*
D055396:Bone Morphogenetic Protein 2; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2