Malignant peripheral nerve sheath tumors of the spine: a SEER database analysis.
Peripheral nerve sheath tumors are uncommon neoplasms that can affect any area of the body. Spinal lesions, especially those that are malignant, pose difficult management challenges, and data regarding these lesions are limited by the disease rarity. This study provides a population-based analysis using the Surveillance, Epidemiology, and End Results (SEER) database, focusing on patient characteristics and treatments. Surgery is associated with improved survival, whereas radiation therapy is associated with decreased survival in this cohort with malignant peripheral nerve sheath tumor in the spine.
Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
James A
JA
Stadler
Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Usama
U
Qadri
Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jessica A
JA
Tang
Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Justin K
JK
Scheer
MD Anderson Cancer Center, Department of Cancer Epidemiology, Houston, TX, USA.
Stephanie C
SC
Melkonian
Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Zachary A
ZA
Smith
Department of Neurosurgery, Baylor College of Medicine, Texas Children's Hospital, 6701 Fannin Street, CCC 1230, Houston, TX 77030, USA. Electronic address: sandi.lam@bcm.edu.
Sandi K
SK
Lam
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D018672:Community Health Planning; D016208:Databases, Factual / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010524:Peripheral Nervous System Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000601:surgery; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000601:surgery; D055815:Young Adult
MPNST; Peripheral nerve sheath tumor; Radiation therapy; SEER database; Spine surgery