Pretreatment with Saccharomyces boulardii does not prevent the experimental mucositis in Swiss mice.
BACKGROUND
The antimetabolite chemotherapy 5-Fluorouracil is one of the most commonly prescribed drugs in clinical cancer treatment. Although this drug is not specific for cancer cells and also acts on healthy cells, it can cause mucositis, a common collateral effect. Dysbiosis has also been described in 5-fluorouracil-induced mucositis and is likely to contribute to the overall development of mucositis. In light of this theory, the use of probiotics could be a helpful strategy to alleviate mucositis. So the aim of this study was evaluate the impact of the probiotic Saccharomyces boulardii in a model of mucositis.


RESULTS
After induced of mucositis, mice from the Mucositis groups showed a decrease in food consumption (p < 0.05) and therefore had a greater weight loss (p < 0.05). The treatment with Saccharomyces boulardii did not reverse this effect (p > 0.05). Mucositis induced an increase in intestinal permeability and intestinal inflammation (p < 0.05). There were no differences in mucosal lesions, intestinal permeability and sIgA secretion (p > 0.05) in mice pretreated with S. boulardii.


CONCLUSIONS
S. boulardii was not able to prevent the effects of experimental mucositis induced by 5- Fluorouracil.
Tatiani Uceli
TU
Maioli
Brenda
B
de Melo Silva
Michelle Nobre
MN
Dias
Nivea Carolina
NC
Paiva
Valbert Nascimento
VN
Cardoso
Simone Odilia
SO
Fernandes
Cláudia Martins
CM
Carneiro
Flaviano
F
Dos Santos Martins
Departamento de Nutrição, Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil. simonenutufmg@gmail.com.
Simone
S
de Vasconcelos Generoso
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects; D005247:Feeding Behavior; D005472:Fluorouracil / Q000009:adverse effects; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D051379:Mice; D052016:Mucositis / Q000139:chemically induced / Q000517:prevention & control*; D019936:Probiotics; D012440:Saccharomyces; D015431:Weight Loss
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil