Atypical plasma lipid profile in cancer patients: cause or consequence?
The aberrant blood lipoprotein levels in cancer patients are reported to be associated with cancer risk and mortality incidents however, there are several discrepancies in the previous reports. Hence the clinical usefulness of plasma/serum levels in risk stratification of a variety of cancers remains elusive. The present review highlights and compiles findings from different research groups regarding association of plasma lipoprotein levels with the risk of developing various types of cancer. We will discuss some prospective underlying mechanisms for this reported association. In addition to that the potential roles of plasma lipids in promoting carcinogenesis will be conferred.
Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.
Rimsha
R
Munir
Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.
Hina
H
Usman
Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.
Shahida
S
Hasnain
Department of Oncology, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
Karine
K
Smans
Medical and Natural Sciences Research Centre, University of Tubingen, Germany; Interfacultary Institute of Biochemistry, University of Tubingen, Germany.
Hubert
H
Kalbacher
Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan. Electronic address: nzzaidi@yahoo.com.
Nousheen
N
Zaidi
D008076:Cholesterol, HDL / Q000097:blood*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D009369:Neoplasms / Q000097:blood* / Q000145:classification / Q000473:pathology; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood*
D008076:Cholesterol, HDL; D008074:Lipoproteins; D014280:Triglycerides
Cancer; Lipoproteins; Plasma lipids; Serum lipids