Tumor-infiltrating lymphocytes favor the response to chemoradiotherapy of head and neck cancer.
Tumor-infiltrating lymphocytes (TILs) play an important role in the response of neoplastic lesions to therapy. We have recently shown that a robust tumor infiltration by CD3+and CD8+T cells correlates with improved disease outcome upon definitive chemoradiotherapy in patients with head and neck cancer, in a manner that is influenced by tumor compartment and human papilloma virus status. Our data highlight the prognostic and therapeutic relevance of TILs in head and neck cancer.
Department of Radiation Therapy and Oncology; Johann Wolfgang Goethe University; Frankfurt, Germany.
Panagiotis
P
Balermpas
Department of Radiation Therapy and Oncology; Johann Wolfgang Goethe University; Frankfurt, Germany.
Franz
F
Rödel
Department of Radiation Therapy and Oncology; Johann Wolfgang Goethe University; Frankfurt, Germany.
Christian
C
Weiss
Department of Radiation Therapy and Oncology; Johann Wolfgang Goethe University; Frankfurt, Germany.
Claus
C
Rödel
Department of Radiation Therapy and Oncology; Johann Wolfgang Goethe University; Frankfurt, Germany.
Emmanouil
E
Fokas
HPV; head and neck cancer; prognostic value; radiotherapy; tumor infiltrating lymphocytes