Sleep disorders and its related risk factors in patients undergoing chronic peritoneal dialysis.
BACKGROUND
The prevalence of sleep disorders has been shown to be high in patients with chronic dialysis patients and may contribute to impaired quality of life and higher mortality in this population. However, there are few data on the relationship of sleep disorders and their risk factors in chronic dialysis patients. The aim of this study was to evaluate the relationship of sleep disorders and their risk factors in chronic dialysis patients.


METHODS
A total of 42 continuous ambulatory peritoneal dialysis (CAPD) patients were involved in this cross-sectional study. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). Restless legs syndrome (RLS) was diagnosed according to the criteria of the International Restless Legs Syndrome Study Group. And depression was assessed by Hamilton depression scale. General information and laboratory data were collected.


RESULTS
The prevalence of sleep disorders was 47.6% in the CAPD patients. According to the PSQI, the 42 CAPD patients were divided into sleep disturbance group and non-sleep disorders group. There were no significant differences in age, gender, dialysis duration, hemoglobin, serum creatinine, urea nitrogen, β2-microglobulin, parathyroid hormone, calcium, and phosphorus between CAPD patients with sleep disorders and those without sleep disorders. But the level of serum albumin (Alb) in CAPD patients with sleep disorders was significantly lower than that in CAPD patients without sleep disorders (31.3 ± 1.4 vs. 34.3 ± 3.7, t = 3.603, P = 0.001) . And the prevalence of RLS and depression was significantly higher than that in CAPD patients without sleep disorders (RLS: 11/22 vs. 1/20, χ(2) = 10.395, P = 0.001; depression: 7/22 vs. 1/20, χ(2) = 4.886, P = 0.027). In CAPD patients with RLS, the prevalence of sleep disorders was significantly higher than that in CAPD patients without RLS (11/22 vs. 11/30, χ(2) = 10.395, P = 0.001). And in CAPD patients with depression, the prevalence of sleep disorders was significantly higher than that in CAPD patients without depression (7/8 vs. 15/34, χ(2) = 4.886, P = 0.027). In CAPD patients, bivariate correlation analysis showed that sleep disorders was negatively correlated with serum Alb (r = -0.606, P = 0.000) and positively correlated with RLS (r = 0.497, P = 0.001) and depression (r = 0.341, P = 0.029). Multivariate regression analysis revealed that the odds ratio of RLS, depression, and low serum Alb was 22.900, 42.209, and 0.597, respectively.


CONCLUSIONS
The prevalence of sleep disorders was relatively high in CAPD patients. RLS, depression, and low serum Alb were the risk factors for CAPD patients with sleep disorders.
Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University; Nephrology Faculty, Capital Medical University, Beijing 100020, China.
Han
H
Li
Institute of Urology, Capital Medical University, Beijing 100020, China.
Xiaobei
X
Li
Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University; Nephrology Faculty, Capital Medical University, Beijing 100020, China.
Sujuan
S
Feng
Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University; Nephrology Faculty, Capital Medical University, Beijing 100020, China.
Guizhi
G
Zhang
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China. Email: zico73@medmail.com.cn.
Wei
W
Wang
Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University; Nephrology Faculty, Capital Medical University, Beijing 100020, China.
Shixiang
S
Wang
D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000097:blood / Q000150:complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D011788:Quality of Life; D012148:Restless Legs Syndrome / Q000097:blood / Q000150:complications / Q000453:epidemiology; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism; D012893:Sleep Wake Disorders / Q000097:blood / Q000453:epidemiology* / Q000209:etiology
D012709:Serum Albumin