A new quinoline alkaloid from the roots of Dictamnus angustifolius.
OBJECTIVE
To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet (Rutaceae).


METHODS
The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis.


RESULTS
A new quinoline alkaloid, 5-methoxylrobustine (1), along with five known quinoline alkaloids were obtained, and their structures were identified as dictamnine (2), robustine (3), isopteleine (4), γ-fagarine (5), and skimmianine (6). Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells (MCF7).


CONCLUSIONS
Compound 1 is a new quinoline alkaloid. Alkaloid 3 showed stronger anti-proliferation effect than the other alkaloids.
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Jian-Bo
JB
Sun
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Wei
W
Qu
Institute of Botany, Jiangsu Province and Chinese Academy of Science, Nanjing 210014, China.
Fu-Qin
FQ
Guan
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Lin-Zhen
LZ
Li
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: jyliang08@126.com.
Jing-Yu
JY
Liang
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D036905:Dictamnus / Q000737:chemistry*; D006801:Humans; D006912:Hydroxyquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use
C000593246:5-methoxylrobustine; D000972:Antineoplastic Agents, Phytogenic; D006912:Hydroxyquinolines; D010936:Plant Extracts; D011804:Quinolines; C035932:skimmianine; C026398:dictamnine
5-Methoxylrobustine; Cytotoxicity; Dictamnus angustifolius; Quinoline alkaloids