Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics.
Inward rectifier potassium (Kir) channels play fundamental roles in cardiac and renal function and may represent unexploited drug targets for cardiovascular diseases. However, the limited pharmacology of Kir channels has slowed progress toward exploring their integrative physiology and therapeutic potential. Here, we review recent progress toward developing the small-molecule pharmacology for Kir2.x, Kir4.1, and Kir7.1 and discuss common mechanistic themes that may help guide future Kir channel-directed drug discovery efforts.
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, United States.
Daniel R
DR
Swale
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, United States.
Sujay V
SV
Kharade
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, United States; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, United States; Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, United States; Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN 37232, United States. Electronic address: Jerod.S.Denton@Vanderbilt.Edu.
Jerod S
JS
Denton
D000818:Animals; D006331:Heart Diseases / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy* / Q000378:metabolism; D008958:Models, Molecular; D024661:Potassium Channels, Inwardly Rectifying / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
D024661:Potassium Channels, Inwardly Rectifying