9-1-1: HSCs respond to emergency calls.
In this issue of Cell Stem Cell, Zhao et al. (2014) and Schürch et al. (2014) describe two new stem cell mechanisms underlying protective responses to infection. In response to inflammatory signals, HSPCs and MSCs produce cytokines that stimulate HSC mobilization and differentiation toward innate immune cells at the expense of adaptive immune lineages.
Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02151, USA.
Robert S
RS
Welner
Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA. Electronic address: kincade@omrf.org.
Paul W
PW
Kincade
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D039902:Multipotent Stem Cells / Q000166:cytology*; D022423:Myeloid Cells / Q000166:cytology*; D038042:Myelopoiesis / Q000502:physiology*; D013312:Stress, Physiological; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D016207:Cytokines