AduoLa Fuzhenglin down-regulates microwave-induced expression of β1-adrenergic receptor and muscarinic type 2 acetylcholine receptor in myocardial cells of rats.
This paper is aimed to study the effect of ADL on expression of β1-AR and M2-AchR in myocardial cells of rats exposed to microwave radiation. Immunohistochemistry, Western blot and image analysis were used to detect the expression of β1-AR and M2-AchR in myocardial cells at 7 and 14 d after microwave exposure. The results show that the expression level was higher in microwave exposure group and 0.75 g/(kg•d) ADL group than in sham operation group and significantly lower in 1.5 and 3.0 g/(kg•d) ADL groups than in microwave group. So we have a conclusion that the expression of β1-AR and M2-AchR is down-regulated in myocardial cells of rats exposed to microwave radiation. ADL can protect rats against microwave-induced heart tissue injury.
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Jing
J
Zhang
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Rui Yun
RY
Peng
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Ya Bing
YB
Gao
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Shui Ming
SM
Wang
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Lei Lei
LL
Yang
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Li
L
Zhao
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Ji
J
Dong
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Bin Wei
BW
Yao
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Gong Min
GM
Chang
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Lu
L
Xiong
D000818:Animals; D015536:Down-Regulation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D008297:Male; D008872:Microwaves / Q000009:adverse effects*; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D020011:Protective Agents / Q000494:pharmacology; D017208:Rats, Wistar; D043585:Receptor, Muscarinic M2 / Q000378:metabolism*; D018342:Receptors, Adrenergic, beta-1 / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D043585:Receptor, Muscarinic M2; D018342:Receptors, Adrenergic, beta-1