Co-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice.
Infection with multiple parasite species is clearly the norm rather than the exception, in animals as well as in humans. Filarial nematodes and Plasmodium spp. are important parasites in human public health and they are often co-endemic. Interactions between these parasites are complex. The mechanisms underlying the modulation of both the course of malaria and the outcome of filarial infection are poorly understood. Despite increasing activity in recent years, studies comparing co- and mono-infections are very much in their infancy and results are contradictory at first sight. In this study we performed controlled and simultaneous co-infections of BALB/c mice with Litomosoides sigmodontis filaria and with Plasmodium spp. (Plasmodium yoelii 17 XNL or Plasmodium chabaudi 864VD). An analysis of pathological lesions in the kidneys and lungs and a parasitological study were conducted at different times of infection. Whatever the plasmodial species, the filarial recovery rate was strongly decreased. The peak of parasitaemia in the plasmodial infection was decreased in the course of P. yoelii infection but not in that of P. chabaudi. Regarding pathological lesions, L. sigmodontis can reverse lesions in the kidneys due to the presence of both Plasmodium species but does not modify the course of pulmonary lesions. The filarial infection induces granulomas in the lungs.
UMR 7245 MCAM MNHN CNRS, Muséum National d'Histoire Naturelle, 61 rue Buffon, CP 52, 75231 Paris Cedex 05, France.
Gregory
G
Karadjian
Service d'Anatomie et de Cytologie Pathologique, Paris, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris France, and EA3102, Université Paris 7, France.
Dominique
D
Berrebi
UMR 7245 MCAM MNHN CNRS, Muséum National d'Histoire Naturelle, 61 rue Buffon, CP 52, 75231 Paris Cedex 05, France.
Nathalie
N
Dogna
UMR 7245 MCAM MNHN CNRS, Muséum National d'Histoire Naturelle, 61 rue Buffon, CP 52, 75231 Paris Cedex 05, France.
Nathaly
N
Vallarino-Lhermitte
UMR 7245 MCAM MNHN CNRS, Muséum National d'Histoire Naturelle, 61 rue Buffon, CP 52, 75231 Paris Cedex 05, France.
Odile
O
Bain
UMR 7245 MCAM MNHN CNRS, Muséum National d'Histoire Naturelle, 61 rue Buffon, CP 52, 75231 Paris Cedex 05, France.
Irène
I
Landau
UMR 7245 MCAM MNHN CNRS, Muséum National d'Histoire Naturelle, 61 rue Buffon, CP 52, 75231 Paris Cedex 05, France.
Coralie
C
Martin
D000818:Animals; D060085:Coinfection / Q000097:blood* / Q000469:parasitology; D016207:Cytokines / Q000097:blood; D005260:Female; D005368:Filariasis / Q000097:blood / Q000150:complications* / Q000469:parasitology; D005370:Filarioidea / Q000302:isolation & purification* / Q000502:physiology; D005921:Glomerulonephritis / Q000097:blood / Q000469:parasitology / Q000473:pathology; D006099:Granuloma / Q000469:parasitology; D006420:Hemeproteins / Q000032:analysis; D008174:Lung Diseases, Parasitic / Q000097:blood / Q000469:parasitology / Q000473:pathology; D008264:Macrophages / Q000737:chemistry; D008288:Malaria / Q000097:blood / Q000150:complications* / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D008842:Microfilariae / Q000302:isolation & purification; D009000:Monocytes / Q000737:chemistry; D059208:Parasite Load; D018512:Parasitemia / Q000469:parasitology*; D016788:Plasmodium chabaudi / Q000302:isolation & purification* / Q000502:physiology; D010967:Plasmodium yoelii / Q000302:isolation & purification* / Q000502:physiology; D035422:Pleural Cavity / Q000469:parasitology; D013163:Splenomegaly / Q000469:parasitology
D016207:Cytokines; D006420:Hemeproteins; C020753:hemozoin