[Cardiovascular and gastrointestinal safety of NSAIDs].
All NSAIDs may induce cardiotoxicity. In this respect naproxen is relatively the safest choice. Selective cyclo-oxygenase-2-inhibitors (coxibs) are at least as effective in preventing clinically relevant gastrointestinal toxicity as non-selective NSAIDs plus a protonpump inhibitor (PPI). Non-selective NSAIDs plus a PPI are more effective in prevention of dyspepsia than coxibs. After a serious gastrointestinal complication while using NSAIDs, in principal the patient should no longer use NSAIDs. If needed, a coxib plus a PPI is the first choice.
*Dit artikel is in iets gewijzigde vorm gepubliceerd in Pharmaceutisch Weekblad Wetenschappelijk Platform (Van den Bemt PMLA, Kuipers EJ, Tjwa ETTL. Cardiovasculaire en gastro-intestinale veiligheid van NSAID's. 2014;8:a1420).
Patricia  M L A
P
van den Bemt
Eric T T L
ET
Tjwa
Martijn G H
MG
van Oijen
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000517:prevention & control; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D009288:Naproxen; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D054328:Proton Pump Inhibitors; D009288:Naproxen