Gene delivery for cancer therapy.
Gene therapy has potential in the treatment of human cancers. However, its clinical implication has only achieved little success due to the lack of an efficient gene delivery system. A major hurdle in the current available approaches is in the ability to transduce target tissues at very high efficiencies that ultimately lead to therapeutic levels of transgene expression. This review outlines the characteristics and utilities of several available gene delivery systems, including their advantages and drawbacks in the context of cancer treatment. A perspective of existing challenges and future directions is also included.
College of Computer, Mathematical, & Natural Sciences, University of Maryland, 2300 Symons Hall, College Park, MD 20742, United States. zhangt682@gmail.com.
Teng
T
Zhang
D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D008081:Liposomes; D008280:Magnetics; D053768:Metal Nanoparticles; D009369:Neoplasms / Q000628:therapy
D008081:Liposomes