[Reccurent mycobacterial diseases in patients with impaired axis IL-12/INF-gamma].
Mycobacteria is a large group of pathogens that are common in environment, in soil and tap water. Although mycobacteria [non tuberculosis mycobacteria] can inhabit body surface without causing any disease in the circumstances of primary or secondary immunodeficiency can cause clinically significant organ or systemic damage. Defect of IL-12/INFgamma axis is an example of primary immunodeficiency that predispose to mycobacterial infections while protection against other microorganisms is not damaged. We present review of known defects of IL-12/IFNgamma axis and brief presentation of our own experience.
Magdalena
M
Strach
Piotr
P
Nalepa
Joanna
J
Sulicka-Grodzicka
Izabella
I
Kierzkowska
Maciej
M
Siedlar
Tomasz
T
Grodzicki
D004476:Ectodermal Dysplasia / Q000235:genetics / Q000276:immunology*; D040181:Genetic Diseases, X-Linked / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology*; D018664:Interleukin-12 / Q000172:deficiency*; D009164:Mycobacterium Infections / Q000235:genetics / Q000276:immunology*; D000081207:Primary Immunodeficiency Diseases; D012008:Recurrence
D018664:Interleukin-12