Bone disease in anorexia nervosa.
Anorexia nervosa is a serious psychiatric disorder accompanied by high morbidity and mortality. It is characterized by emaciation due to self-starvation and displays a unique hormonal profile. Alterations in gonadal axis, growth hormone resistance with low insulin-like growth factor I levels, hypercortisolemia and low triiodothyronine levels are almost universally present and constitute an adaptive response to malnutrition. Bone metabolism is likewise affected resulting in low bone mineral density, reduced bone accrual and increased fracture risk. Skeletal deficits often persist even after recovery from the disease with serious implications for future skeletal health. The pathogenetic mechanisms underlying bone disease are quite complicated and treatment is a particularly challenging task.
Department of Endocrinology and Metabolism, Hippokrateion General Hospital, Athens, Greece.
Anastasia D
AD
Dede
Hellenic Osteoporosis Foundation, Athens, Greece.
George P
GP
Lyritis
Laboratory for Research of Musculoskeletal System "Theodoros Garofalidis", University of Athens, KAT Hospital; Athens, Greece.
Symeon
S
Tournis
D000856:Anorexia Nervosa / Q000150:complications* / Q000378:metabolism; D015519:Bone Density / Q000502:physiology*; D001847:Bone Diseases / Q000209:etiology* / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D050723:Fractures, Bone / Q000209:etiology* / Q000378:metabolism; D006801:Humans