Fluorogenic resveratrol-confined graphene oxide for economic and rapid detection of Alzheimer's disease.
Developing an effective means for the real-time probing of amyloid β (Aβ) that is closely implicated in Alzheimer's disease (AD) could help better understand and monitor the disease. Here we describe an economic approach based on the simple composition of a natural product, resveratrol (Res), with graphene oxide (GO) for the rapid, fluorogenic recognition of Aβ. The Res@GO composite has proved specific for Aβ over a range of proteins and ions, and could sensitively capture both Aβ monomers and fibers in a physiological buffer solution within only 3 min. The composite can also fluorescently image amyloid deposits in a mouse brain section within 30 min. This new protocol is much cheaper and more timesaving than the conventional immunofluorescence staining technique employed clinically, providing an economic tool for the concise detection of AD.
Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, P. R. China.
Xiao-Peng
XP
He
Qiong
Q
Deng
Liang
L
Cai
Chang-Zheng
CZ
Wang
Yi
Y
Zang
Jia
J
Li
Guo-Rong
GR
Chen
He
H
Tian
D000544:Alzheimer Disease / Q000175:diagnosis* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D005453:Fluorescence; D005455:Fluorescent Antibody Technique / Q000295:instrumentation / Q000379:methods*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D051379:Mice; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry*
D016229:Amyloid beta-Peptides; D013267:Stilbenes; D006108:Graphite; D000077185:Resveratrol