Lipotoxicity, β cell dysfunction, and gestational diabetes.
Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed that CMPF directly induces β cell dysfunction.
Department of Endocrinology at Canberra Hospital and the Australian National University Medical School, Canberra, Australian Capital Territory 2605, Australia. Electronic address: christopher.nolan@anu.edu.au.
Christopher J
CJ
Nolan
D000818:Animals; D005663:Furans / Q000097:blood*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000473:pathology*; D008928:Mitochondria / Q000473:pathology*; D008954:Models, Biological; D029362:Organic Anion Transporters, Sodium-Independent / Q000378:metabolism*; D011422:Propionates / Q000097:blood*
C468134:3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid; D005663:Furans; D029362:Organic Anion Transporters, Sodium-Independent; D011422:Propionates; C114338:organic anion transport protein 3