How human tumor viruses make use of autophagy.
Viruses commandeer regulatory pathways of their hosts to optimize their success as cellular parasites. The human tumor viruses, Epstein-Barr Virus (EBV), Kaposi's Sarcoma Herpesvirus (KSHV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) all affect autophagy for their own ends. EBV and KSHV regulate it during latent infections, a phase when no progeny virus is produced, while HBV and HCV use autophagy to promote their productive infections. Here we shall compare and contrast how these human tumor viruses regulate autophagy and what they gain by the appropriation of this cellular pathway.
Department of Bacteriology and Food Research Institute, Microbial Sciences Building, University of Wisconsin-Madison, Madison, WI 53706, USA. zpratt@wisc.edu.
Zachary L
ZL
Pratt
Department of Oncology, McArdle Laboratory for Cancer Research, Madison, WI 53706, USA. sugden@oncology.wisc.edu.
Bill
B
Sugden