Acetyl-CoA synthetase is a conserved regulator of autophagy and life span.
Autophagy is essential for the maintenance of cellular homeostasis during periods of stress. Eisenberg and colleagues (Eisenberg et al., 2014) now describe the central and conserved role for acetyl-CoA synthetase in regulating life span in yeast and flies by a mechanism involving autophagy.
Longevity Institute, School of Gerontology and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA.
Hamed
H
Mirzaei
Longevity Institute, School of Gerontology and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA. Electronic address: vlongo@usc.edu.
Valter D
VD
Longo
D000818:Animals; D001343:Autophagy; D003066:Coenzyme A Ligases / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D008136:Longevity
D029721:Drosophila Proteins; D003066:Coenzyme A Ligases