1958-2014: after 56 years of research, cytochrome p450 reactivity is finally explained.
Nature's wisdom in enzyme design: Compounds I and II in the catalytic cycle of the Cytochrome P450 enzymes have been trapped and characterized recently. This work has provided further insight into the electronic structure and reactivity of these crucial intermediates, and key questions regarding the mechanism of these enzymes have finally been answered.
Department of Chemistry, University of Michigan, 930 N. University, Ann Arbor, MI 48109 (USA).
Ashley B
AB
McQuarters
Matthew W
MW
Wolf
Andrew P
AP
Hunt
Nicolai
N
Lehnert
D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D049673:History, 20th Century; D049674:History, 21st Century; D013056:Spectrophotometry, Ultraviolet
D003577:Cytochrome P-450 Enzyme System
Cytochrome P450; CH bond activation; hydroxylation; monooxygenases