TH17 cells are increased in the peripheral blood of patients with SAPHO syndrome.
To assess whether the immune derangement previously observed in SAPHO syndrome could be linked to variations in blood TH1, TH2 or TH17 lymphocytes frequency. Seven SAPHO patients with a protracted course of the disease were studied ex-vivo for intracellular cytokines production by means of flow-cytometry and compared with matched groups of Psoriatic Arthritis patients and healthy controls. The Kruskal-Wallis test on the median of the three categories showed that there is a significant association between the TH17 levels and the category (p value = 0.02474). The mean and variance for the proportion of IL-17 producing CD4+ cells were compared between groups showing significant differences between SAPHO versus PsA subgroup (p = 0.05) and SAPHO versus healthy controls (p = 0.008). Interestingly, activation of TH17 axis, but not of TH1 and TH2, has been found, and can be observed both in patients with different activity of the disease or treated with different drugs. The TH17 increase in peripheral blood of our SAPHO subjects resembles the one recently found in patients with different AIDs. Novel therapeutic options in these patients may therefore include IL-17 blockade.
Unit of Internal Medicine, Allergy and Clinical Immunology, Department of Medical Sciences "M. Aresu", University of Cagliari , Monserrato , Italy .
Davide
D
Firinu
Maria Pina
MP
Barca
Maria Maddalena
MM
Lorrai
Silvia
S
Perra
Stefano
S
Cabras
Emma
E
Muggianu
Maria Luisa
ML
Di Martino
Paolo Emilio
PE
Manconi
Stefano R
SR
Del Giacco
D020083:Acquired Hyperostosis Syndrome / Q000097:blood / Q000276:immunology*; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002452:Cell Count; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis / Q000276:immunology; D008213:Lymphocyte Activation; D008875:Middle Aged; D058504:Th17 Cells / Q000276:immunology* / Q000473:pathology
D020381:Interleukin-17
Autoinflammatory; CRMO; TH17; inflammation; interleukin-1β; osteitis