Formulation optimization of arecoline patches.
The response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K30 (PVP), plasticizers (PEG 400), and drug. In addition, using terpenes as enhancers could increase the flux of the drug. Menthol showed the highest enhancement effect on the flux of arecoline.
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.
Pao-Chu
PC
Wu
Department of Business Administration, I-Shou University, No. 1, Section 1, Syuecheng Road, Dashu, Kaohsiung 84001, Taiwan.
Pi-Ju
PJ
Tsai
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.
Shin-Chen
SC
Lin
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.
Yaw-Bin
YB
Huang
D000818:Animals; D001115:Arecoline / Q000008:administration & dosage* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D051381:Rats; D057968:Transdermal Patch
D001115:Arecoline