A flexible solution to anion transport: powerful anionophores based on a cyclohexane scaffold.
Transmembrane anion carriers (anionophores) have potential for biological activity, including the treatment of channelopathies such as cystic fibrosis. A new family of anionophores has been synthesized, in which three thiourea groups are mounted on a cyclohexane-based scaffold. Though conceptually related to earlier polycyclic systems, these molecules are simpler and far more accessible. Preorganization is somewhat reduced compared to earlier systems, and anion affinities are correspondingly lower. However, transport activities set new records. This surprising performance suggests a role for controlled flexibility in the design of transmembrane anion carriers.
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS (UK).
James A
JA
Cooper
Steven T G
ST
Street
Anthony P
AP
Davis
D000838:Anions / Q000737:chemistry; D003510:Cyclohexanes / Q000737:chemistry*; D006860:Hydrogen Bonding; D017136:Ion Transport; D013890:Thiourea / Q000737:chemistry
D000838:Anions; D003510:Cyclohexanes; C506365:Cyclohexane; D013890:Thiourea
anion binding; anion transport; molecular recognition; receptors; supramolecular chemistry