Evaluation of vitamin D supplementation doses during pregnancy in a population at high risk for deficiency.
OBJECTIVE
Vitamin D supplementation during pregnancy is a well-accepted recommendation worldwide; however, the debate about the correct dose is ongoing. We aimed to compare daily doses of 600, 1,200, and 2,000 IU in this randomized, controlled study.


METHODS
The study group consisted of 91 pregnant women aged 16-42 years admitted to Kocaeli Maternity and Children Hospital between April 2011 and April 2012. The participants were randomly divided into 3 groups. 600, 1,200, and 2,000 IU/day of vitamin D was supplemented to group 1 (control group, n = 31), group 2 (n = 31), and group 3 (n = 32), respectively. Serum calcium, 25-hydroxyvitamin D (25OHD), and the calcium/creatinine ratio in spot urine samples were measured in the follow-up period. The serum calcium and 25OHD levels of the mothers' infants were measured as well.


RESULTS
The frequency of vitamin D sufficiency after supplementation was 80% in group 3 and it was significantly higher than in groups 1 (42%) and 2 (39%) (p = 0.03). The frequency of vitamin D sufficiency in the infants of the participants was 91% in group 3 and it was significantly higher than in groups 1 (36%) and 2 (52%) (p = 0.006).


CONCLUSIONS
At least 2,000 IU/day of vitamin D is needed to ensure adequate vitamin D status in pregnancy and early infancy.
Division of Pediatric Endocrinology and Diabetes, School of Medicine, Kocaeli University, Kocaeli, Turkey.
Gul
G
Yesiltepe Mutlu
Elif
E
Ozsu
Sibel
S
Kalaca
Aysegul
A
Yuksel
Yuksel
Y
Pehlevan
Filiz
F
Cizmecioglu
Sukru
S
Hatun
D000328:Adult; D002118:Calcium / Q000097:blood / Q000652:urine; D002762:Cholecalciferol / Q000008:administration & dosage*; D003404:Creatinine / Q000652:urine; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D011247:Pregnancy; D014421:Turkey / Q000453:epidemiology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology
D014807:Vitamin D; D002762:Cholecalciferol; C104450:25-hydroxyvitamin D; D003404:Creatinine; D002118:Calcium