Drosophila melanogaster as a genetic model system to study neurotransmitter transporters.
The model genetic organism Drosophila melanogaster, commonly known as the fruit fly, uses many of the same neurotransmitters as mammals and very similar mechanisms of neurotransmitter storage, release and recycling. This system offers a variety of powerful molecular-genetic methods for the study of transporters, many of which would be difficult in mammalian models. We review here progress made using Drosophila to understand the function and regulation of neurotransmitter transporters and discuss future directions for its use.
UCLA Interdepartmental Program in Molecular Toxicology, United States.
Ciara A
CA
Martin
Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine University of California, Los Angeles, CA 90095, United States. Electronic address: dkrantz@ucla.edu.
David E
DE
Krantz
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000378:metabolism*; D006801:Humans; D050479:Neurotransmitter Transport Proteins / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D050481:Vesicular Neurotransmitter Transport Proteins / Q000235:genetics / Q000378:metabolism
D029721:Drosophila Proteins; D050479:Neurotransmitter Transport Proteins; D050481:Vesicular Neurotransmitter Transport Proteins
Acetylcholine; ChT1; DAT; Dopamine; Drosophila; EAAT; GABA; GAT; Glutamate; Inebriated; Neurotransmitter transporter; Octopamine; Portabella; SERT; SLC1; SLC17; SLC18; SLC6; Serotonin; VAChT; VGAT; VGLUT; VMAT; VNUT; Vesicular transporter