Skilled reach training influences brain recovery following intracerebral hemorrhage in rats.
[Purpose] The present study investigated how skilled reach training influences functional and neurological brain recovery via a rat model with intracerebral hemorrhage. [Subjects] Thirty rats with intracerebral hemorrhage were divided into 2 groups randomly: the control group (CON) that did not receive any treatment, and the experimental group (SRT) that received skilled reach training. [Methods] The experimental group was trained through skilled reaching training with the affected upper limb in 15-minute sessions administered 6 days per week for 4 weeks. [Results] In the behavioral test, the results showed that motor function was significantly improved in the skilled reach training group compared with the control group. In the neurological teat, the expression level of brain-derived neurotrophic factor (BDNF) was significantly increased in the skilled reach training group compared with the control group. [Conclusion] Skilled reach training is able to facilitate both the expression of neurotrophic factor in the motor cortex and motor function recovery following intracerebral hemorrhage.
Department of Rehabilitation Science, Graduate School, Daegu University, Republic of Korea.
Min-Sik
MS
Yong
Department of Physical Therapy, College of Rehabilitation Science, Daegu University, Republic of Korea.
Kak
K
Hwangbo
Brain-derived neurotrophic factor; Intracerebral hemorrhage; Skilled reach training