Genome-wide association study of HPV-associated cervical cancer in Japanese women.
One of the important factors influencing the development of uterine cervical cancer is human papillomavirus infection in women. Usually, the infecting papillomavirus is eliminated from individuals; however, some retain the virus and this is believed to lead to the development of uterine cervical cancer. It is possible that virus elimination or persistent infection depends on an individual's genetic background. To identify single nucleotide polymorphisms associated with susceptibility to persistent infection or cervical cancer, a genome-wide association study was performed on 226 cases and 186 controls. Some of the single nucleotide polymorphisms showed a P-value < 10(-5); however, no polymorphisms that were significantly associated with susceptibility to cervical cancer were identified.
Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Kiyonori
K
Miura
Hiroyuki
H
Mishima
Akira
A
Kinoshita
Chisa
C
Hayashida
Shuhei
S
Abe
Katsushi
K
Tokunaga
Hideaki
H
Masuzaki
Koh-ichiro
K
Yoshiura
D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology*
GWAS; human papilloma virus; susceptibility; uterine cervical cancer