Serum vanin-1 levels in renal transplant patients.
OBJECTIVE
Vascular noninflammatory molecule 1 is a plasma membrane enzyme, also known as pantetheinase. It has been shown that vascular noninflammatory molecule 1 urinary and serum concentrations of vascular noninflammatory molecule 1 increase in nephrotoxicant-induced renal injury before classic markers. Tacrolimus and cyclosporine used as immunosuppressive agents are nephrotoxic drugs. This study sought to investigate alterations of vascular noninflammatory molecule 1 levels after a kidney transplant.


METHODS
This study included 28 renal allograft recipients without acute rejection. Before transplant, and the first and sixth months after the transplant, vascular noninflammatory molecule 1 and creatinine levels were measured in renal transplant recipients using enzyme-linked immunosorbent assay and spectrophotometric methods.


RESULTS
During the first month after transplant, we observed a significant increase in vascular noninflammatory molecule 1 levels compared with previous levels (P < .0001). Also, during the sixth month, vascular noninflammatory molecule 1 levels were higher than values previously taken (P < .01), although they were lower compared with the first month values (P = .004). No correlation was found between vascular noninflammatory molecule 1 and creatinine before transplant or during the first and sixth months after transplant. When the patients were divided into subgroups according to the immunosuppressive drugs used, in tacrolimus-treated patients, serum vascular noninflammatory molecule 1 levels were no different from the cyclosporine-administered levels measured at 3 different times.


CONCLUSIONS
We conclude that serum vascular noninflammatory molecule 1 levels may be low in the end-stage renal failure and transiently increase after transplant owing to transient renal function deterioration, which does not lead to elevation of serum creatinine levels in renal transplant patients.
Department of Medical Biology, Ataturk University, Medical School, Erzurum, Turkey.
Ömer
Ö
Atış
Hülya
H
Aksoy
Mustafa
M
Keleş
Musa
M
Gümüşdere
D000293:Adolescent; D000328:Adult; D000581:Amidohydrolases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
D015415:Biomarkers; D058851:GPI-Linked Proteins; D007166:Immunosuppressive Agents; D003404:Creatinine; D000581:Amidohydrolases; C022314:pantetheinase