Prognostic value of CD117 in cancer: a meta-analysis.
BACKGROUND
The prognostic value of CD117 expression in cancers has been evaluated for several years while the results remain controversial. We thus performed a systematic review and meta-analysis of studies assessing the impact of CD117 expression on overall survival (OS) and disease-free survival (DFS) to clarify this issue.


METHODS
We searched Pubmed, Embase and Web of Science to identify studies on the prognostic impact of CD117 expression in cancers. A total of 4,458 patients from 39 eligible studies were included in the analysis. Pooled risk ratios (RRs) with 95% confidence interval (95% CI) were calculated to estimate the effect using random-effects model.


RESULTS
The analysis indicated that CD117 had significant association with poor OS of osteosarcoma (OR=1.36, 95% CI=1.03-1.79, I2=0%, fixed model) and renal carcinoma (OR=4.86, 95% CI=2.72-8.67, I2=0%, fixed model).However, no significant association between CD117 and DFS was found in overall studies.


CONCLUSIONS
CD117 expression might be a predictive factor of poor prognosis in some surgically treated cancers, particularly in renal carcinoma.
Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College Bengbu, Anhui 233000, China.
Fuyou
F
Zhao
Department of Respiratory Diseases, The First Affiliated Hospital of Bengbu Medical College Bengbu, Anhui 233000, China.
Yuqing
Y
Chen
Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College Bengbu, Anhui 233000, China.
Qiong
Q
Wu
Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College Bengbu, Anhui 233000, China.
Zian
Z
Wang
Department of Microbiology, Bengbu Medical College Bengbu, Anhui 233000, China.
Jie
J
Lu
D014408:Biomarkers, Tumor / Q000032:analysis*; D018572:Disease-Free Survival; D006801:Humans; D007150:Immunohistochemistry; D009369:Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000401:mortality*; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit
CD117; immunohistochemistry; meta-analysis; survival