A mini library of novel triazolothiadiazepinylindole analogues: synthesis, antioxidant and antimicrobial evaluations.
A new series of novel triazolothiadiazepinylindole analogues were synthesized with an aim to examine possible antioxidant and antimicrobial activities. The titled compounds (3a-z) were obtained in good yield by reacting 5-(5-substituted-3-phenyl-1H-indol-2-yl)-4-amino-4H-1,2,4-triazole-3-thiols 1a-c with 3-(2,5-disubstituted-1H-indol-3-yl)-1(4-substituted phenyl)prop-2-en-1-ones 2a-i. All the newly synthesized compounds were characterized by IR, (1)H NMR, mass spectroscopic and analytical data. The synthesized analogues were tested for antioxidant and antimicrobial potency. Among the tested compounds 3a-c and 3j-l have shown very promising free radical scavenging activity and total antioxidant capacity. Compounds 3d-f, 3m-o, and 3s-z have shown excellent ferric reducing antioxidant activity. An outstanding antimicrobial activity is observed with compounds 3a-c and 3j-l.
Central Research Lab, Department of Chemistry, Gulbarga University, Gulbarga, Karnataka State 585 106, India.
Jaiprakash Sharanappa
JS
Biradar
Central Research Lab, Department of Chemistry, Gulbarga University, Gulbarga, Karnataka State 585 106, India ; Smt. V.G. Degree College for Women, Gulbarga, Karnataka State 585 102, India.
Parveen
P
Rajesab
Central Research Lab, Department of Chemistry, Gulbarga University, Gulbarga, Karnataka State 585 106, India.
Naveen Jaiprakash
NJ
Biradar
Central Research Lab, Department of Chemistry, Gulbarga University, Gulbarga, Karnataka State 585 106, India ; Organic Chemistry Section, Chemical Science and Technology Division, National Institute for Interdisciplinary Science and Technology (CSIR), Thiruvanthapuram-695 019, Kerala, India.
Sasidhar Balappa
SB
Somappa
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000975:Antioxidants; D014230:Triazoles