Facile synthesis of halogenated spiroketals via a tandem iodocyclization.
A strategy for the synthesis of spiroketal compounds through a tandem iodocyclization of 1-(2-ethynylphenyl)-4-hydroxybut-2-yn-1-one derivatives is presented. This reaction could proceed under very mild conditions in a short time and avoid the use of expensive and toxic metal catalysts. Moreover, the resulting halides can be further exploited by subsequent palladium-catalyzed coupling reactions, which act as the important intermediates for building other valuable compounds.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P.R. China.
Jia
J
Wang
Hai-Tao
HT
Zhu
Ying-Xiu
YX
Li
Li-Jing
LJ
Wang
Yi-Feng
YF
Qiu
Zi-Hang
ZH
Qiu
Mei-jin
MJ
Zhong
Xue-Yuan
XY
Liu
Yong-Min
YM
Liang