Muscle VO2 and forearm blood flow repeatability during venous and arterial occlusions in healthy and coronary heart disease subjects.
This study aims were: 1) to assess forearm blood flow (FBF) and muscle oxygen consumption (mVO2) repeatability assessed with near-infra red spectroscopy (NIRS) during venous occlusions (VO) in middle aged healthy subjects and patients with stable coronary heart disease (CHD), 2) to assess the agreement between mVO2 calculated from NIRS signals during VO and arterial occlusion (AO) in 18 middle aged healthy subjects and 12 patients with CHD. FBF and mVO2 were measured using NIRS during 2 successive VO (1-min duration), followed by a 5-min AO. Repeatability for FBF and mVO2 during VO was assessed with intra class correlation (ICC), coefficient of variation (CV %) and agreement between VO and AO mVO2 was assessed with a Bland and Altman analysis. FBF and mVO2 during VO were highly reproducible in healthy (FBF: ICC 0.73, CV% 9.75; mVO2: ICC 0.89, CV% 12.6) and CHD subjects (FBF: ICC 0.95, CV% 10.26; mVO2: ICC 0.98, CV% 7.92). VO and AO mVO2 were in agreement in healthy (mean bias: 0.002 mL O2.min-1.100g-1) and CHD subjects (mean bias: 0.014 mL O2.min-1.100g-1). FBF and mVO2 measured with NIRS during VO and/or AO are highly reproducible methods to assess microvascular function in healthy subjects and stable CHD patients.
Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montreal Heart Institute and "Université de Montréal", Montreal, QC, Canada Research Center, Montreal Heart Institute and "Université de Montréal", Montreal, QC, Canada Department of Medicine, Faculty of Medicine, "Université de Montréal", Montreal, Canada.
Mathieu
M
Gayda
Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montreal Heart Institute and "Université de Montréal", Montreal, QC, Canada Research Center, Montreal Heart Institute and "Université de Montréal", Montreal, QC, Canada Department of Medicine, Faculty of Medicine, "Université de Montréal", Montreal, Canada INSERM - U1093 "Cognition, Action, et Plasticité Sensorimotrice", Dijon, France Plateforme d'Investigation Technologique, CIC Inserm 1432, CHU de Dijon, 23 rue Gaffarel, 21079 Dijon, France.
Vincent
V
Gremeaux
Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montreal Heart Institute and "Université de Montréal", Montreal, QC, Canada Research Center, Montreal Heart Institute and "Université de Montréal", Montreal, QC, Canada.
Joffrey
J
Drigny
Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montreal Heart Institute and "Université de Montréal", Montreal, QC, Canada Research Center, Montreal Heart Institute and "Université de Montréal", Montreal, QC, Canada Department of Medicine, Faculty of Medicine, "Université de Montréal", Montreal, Canada.
Martin
M
Juneau
Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montreal Heart Institute and "Université de Montréal", Montreal, QC, Canada Research Center, Montreal Heart Institute and "Université de Montréal", Montreal, QC, Canada Department of Medicine, Faculty of Medicine, "Université de Montréal", Montreal, Canada.
Anil
A
Nigam
D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology*
Near-infra red spectroscopy; agreement; healthy middle aged subjects; patients with coronary heart disease; repeatability; vascular occlusions