Tyrosine-mediated two-dimensional peptide assembly and its role as a bio-inspired catalytic scaffold.
In two-dimensional interfacial assemblies, there is an interplay between molecular ordering and interface geometry, which determines the final morphology and order of entire systems. Here we present the interfacial phenomenon of spontaneous facet formation in a water droplet driven by designed peptide assembly. The identified peptides can flatten the rounded top of a hemispherical droplet into a plane by forming a macroscopic two-dimensional crystal structure. Such ordering is driven by the folding geometry of the peptide, interactions of tyrosine and crosslinked stabilization by cysteine. We discover the key sequence motifs and folding structures and study their sequence-specific assembly. The well-ordered, densely packed, redox-active tyrosine units in the YYACAYY (H-Tyr-Tyr-Ala-Cys-Ala-Tyr-Tyr-OH) film can trigger or enhance chemical/electrochemical reactions, and can potentially serve as a platform to fabricate a molecularly tunable, self-repairable, flat peptide or hybrid film.
1] School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea [2].
Hyung-Seok
HS
Jang
1] School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea [2] Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea [3].
Jung-Ho
JH
Lee
Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea.
Yong-Sun
YS
Park
School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea.
Young-O
YO
Kim
Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea.
Jimin
J
Park
Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea.
Tae-Youl
TY
Yang
Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea.
Kyoungsuk
K
Jin
Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea.
Jaehun
J
Lee
Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea.
Sunghak
S
Park
School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea.
Jae Myoung
JM
You
Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea.
Ki-Woong
KW
Jeong
Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea.
Areum
A
Shin
Department of Chemical Engineering, Inha University, Incheon 402-751, Korea.
In-Seon
IS
Oh
Department of Chemical Engineering, Inha University, Incheon 402-751, Korea.
Min-Kyung
MK
Kwon
Division of Industrial Metrology, Korea Research Institute of Standards and Science, Daejeon 305-340, Korea.
Yong-Il
YI
Kim
Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea.
Hoon-Hwe
HH
Cho
Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea.
Heung Nam
HN
Han
Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea.
Yangmee
Y
Kim
Department of Chemical Engineering, Inha University, Incheon 402-751, Korea.
Yoon Ho
YH
Chang
School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea.
Seung R
SR
Paik
Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea.
Ki Tae
KT
Nam
School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea.
Yoon-Sik
YS
Lee
D002384:Catalysis; D010455:Peptides / Q000737:chemistry*; D014443:Tyrosine / Q000737:chemistry*
D010455:Peptides; D014443:Tyrosine