Glomerular disease: looking beyond pathology.
The National Institute of Diabetes and Digestive and Kidney Diseases-supported Kidney Research National Dialogue asked the scientific community to formulate and prioritize research objectives aimed at improved understanding of kidney function and disease progression. Over the past 2 years, 1600 participants posted almost 300 ideas covering all areas of kidney disease. An overriding theme that evolved through these discussions is the need to move beyond pathology to take advantage of basic science and clinical research opportunities to improve diagnostic classification and therapeutic options for people with primary glomerular disease. High-priority research areas included focus on therapeutic targets in glomerular endothelium and podocytes, regenerating podocytes through developmental pathways, use of longitudinal phenotypically defined disease cohorts to improve classification schemes, identifying biomarkers, disease-specific therapeutics, autoantibody triggers, and changing the clinical research culture to promote participation in clinical trials. Together, these objectives provide a path forward for improving clinical outcomes of glomerular disease.
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Roger C
RC
Wiggins
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Charles E
CE
Alpers
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Lawrence B
LB
Holzman
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John C
JC
He
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David J
DJ
Salant
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Sumant S
SS
Chugh
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Rama
R
Natarajan
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Howard
H
Trachtman
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Lauren
L
Brasile
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Robert A
RA
Star
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Krystyna E
KE
Rys-Sikora
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Marva M
MM
Moxey-Mims
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material. flessnermf@niddk.nih.gov.
Michael F
MF
Flessner
D001323:Autoantibodies; D035843:Biomedical Research; D004730:Endothelium, Vascular; D006801:Humans; D007674:Kidney Diseases / Q000145:classification / Q000209:etiology* / Q000628:therapy; D007678:Kidney Glomerulus / Q000098:blood supply; D050199:Podocytes / Q000166:cytology / Q000378:metabolism; D057285:Precision Medicine
D001323:Autoantibodies
GN; autoantibodies; endothelium; glomerulosclerosis; inflammation; nephrotic syndrome; podocytes; translational and clinical research