Interleukin-28B polymorphisms and response of chronic hepatitis C patients from Indonesia to pegylated interferon/ribavirin treatment.
This study demonstrated that Indonesian patients with chronic hepatitis C (mostly ethnic Java people) mostly were infected with hepatitis C virus (HCV) genotype 1; however, they carried mainly the major genotypes of interleukin 28B (IL-28B) single nucleotide polymorphisms (SNPs) (rs12979860 CC, rs11881222 TT, rs8103142 AA, and rs8099917 TT), and they mostly achieved sustained virological responses to pegylated interferon/ribavirin treatment.
Department of Microbiology, School of Medicine, Airlangga University, Surabaya, East Java, Indonesia Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, East Java, Indonesia.
Juniastuti
Division of Gastroenterohepatology, Department of Internal Medicine, Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia.
Bogi P
BP
Wibowo
Division of Gastroenterohepatology, Department of Internal Medicine, Sanglah General Hospital, Denpasar, Bali, Indonesia.
I D N
ID
Wibawa
Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, East Java, Indonesia Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Takako
T
Utsumi
Division of Gastroenterohepatology, Department of Internal Medicine, Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia.
Syifa
S
Mustika
Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, East Java, Indonesia Institute of Tropical Disease, Airlangga University, Surabaya, East Java, Indonesia.
Mochamad
M
Amin
Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, East Java, Indonesia Institute of Tropical Disease, Airlangga University, Surabaya, East Java, Indonesia.
Rury M
RM
Wahyuni
Institute of Tropical Disease, Airlangga University, Surabaya, East Java, Indonesia.
Hendra
H
Kurniawan
Department of Microbiology, School of Medicine, Udayana University, Denpasar, Bali, Indonesia.
Agus
A
Hendrayana
Department of Internal Medicine, Dr. Soetomo General Hospital, Surabaya, East Java, Indonesia.
Poernomo B
PB
Setiawan
Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Laura N
LN
Yamani
Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, East Java, Indonesia Institute of Tropical Disease, Airlangga University, Surabaya, East Java, Indonesia Department of Biochemistry, School of Medicine, Airlangga University, Surabaya, East Java, Indonesia.
Soetjipto
Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Yoshihiko
Y
Yano
Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Hak
H
Hotta
Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Yoshitake
Y
Hayashi
Department of Microbiology, School of Medicine, Airlangga University, Surabaya, East Java, Indonesia Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, East Java, Indonesia Institute of Tropical Disease, Airlangga University, Surabaya, East Java, Indonesia ingelusida@yahoo.com.
Maria I
MI
Lusida
D000328:Adult; D000368:Aged; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D007214:Indonesia; D016898:Interferon-alpha / Q000627:therapeutic use*; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012254:Ribavirin / Q000627:therapeutic use*; D016896:Treatment Outcome; D000095022:Interferon Lambda
D016898:Interferon-alpha; D007372:Interferons; D007378:Interleukins; D012254:Ribavirin; C000624353:interferon-lambda, human; D000095022:Interferon Lambda