Review: higher vitamin D status and supplementation may be associated with risks.
The prevalence of low vitamin D levels and associated risks has led to an increase in supplementation. However, a "U-shaped" relationship has been suggested between vitamin D status and adverse effects, with risks observed both in low and high levels. While risks associated with low levels of vitamin D have been extensively studied, the risks of higher levels of vitamin D have not been as widely circulated. We sought to describe key observed adverse risks with vitamin D supplementation and higher serum 25(OH)-D levels in healthy adult populations.
Dermatoepidemiology Unit, VA Medical Center, 830 Chalkstone Avenue, 514, Providence, Rhode Island 02908, USA, Department of Dermatology.
Kaveri
K
Korgavkar
Dermatoepidemiology Unit, VA Medical Center, 830 Chalkstone Avenue, 514, Providence, Rhode Island 02908, USA, Department of Dermatology.
Michael
M
Xiong
Dermatoepidemiology Unit, VA Medical Center, 830 Chalkstone Avenue, 514, Providence, Rhode Island 02908, USA, Department of Dermatology,, Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island, USA, Department of Epidemiology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Martin A
MA
Weinstock
D000058:Accidental Falls / Q000706:statistics & numerical data; D001249:Asthma / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology; D019587:Dietary Supplements / Q000009:adverse effects*; D050723:Fractures, Bone / Q000453:epidemiology; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D009026:Mortality; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality; D017410:Practice Guidelines as Topic; D015995:Prevalence; D012307:Risk Factors; D014807:Vitamin D / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood*; D014808:Vitamin D Deficiency / Q000453:epidemiology / Q000517:prevention & control; D014815:Vitamins / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood*
D006887:Hydroxycholecalciferols; D014815:Vitamins; D014807:Vitamin D
epidemiology; vitamin D