The three most important things about origins: location, location, location.
The reasons why some DNA replication origins fire earlier than others have remained elusive. New work by Gindin et al suggests that the distribution of replication origins, not their timing per se, is the major determinant of the timing of genome replication in human cells.
Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA.
Nicholas
N
Rhind
D002843:Chromatin / Q000648:ultrastructure*; D004261:DNA Replication / Q000235:genetics*; D042522:DNA Replication Timing / Q000235:genetics*; D006801:Humans
D002843:Chromatin