Synthesis and properties of PDMS/montmorillonite-cetyltrimethylammonium bromide-heparin films.
In this study, poly(dimethylsiloxane)(PDMS)/montmorillonite-cetyltrimethylammonium bromide-heparin (PDMS/MMT-CTAB-HEP) films were prepared by solution intercalation technique. The cetyltrimethylammonium bromide-heparin (CTAB-HEP) was intercalated into montmorillonite (MMT) layers forming MMT-CTAB-HEP (modified MMT). The structure and properties of the film were characterized by XRD, TG and SEM. The modified MMT was homogeneously dispersed within the PDMS matrix. The effect of modified MMT on mechanical properties of the film was also investigated. As the modified MMT content was lower than 2wt%, the films showed excellent mechanical properties. The blood compatibility of PDMS/MMT-CTAB-HEP films was further evaluated by hemolysis test and platelet adhesion. Both hemolysis and platelet adhesions tests showed that PDMS/MMT-CTAB-HEP film had better blood compatibility than pure PDMS.
Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210046, China; Jiangsu Key Laboratory for Supramolecular Medicinal Materials and Applications, College of Life Science, Nanjing Normal University, Nanjing 210046, China.
Na Meng
Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210046, China; Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China; Jiangsu Technological Research Center for Interfacial Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. Electronic address: zhouninglin@njnu.edu.cn.
Ning-Lin
NL
Zhou
D001546:Bentonite / Q000032:analysis / Q000138:chemical synthesis*; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000032:analysis / Q000138:chemical synthesis*; D004129:Dimethylpolysiloxanes / Q000032:analysis / Q000138:chemical synthesis*; D006493:Heparin / Q000032:analysis / Q000138:chemical synthesis*; D014961:X-Ray Diffraction
D002593:Cetrimonium Compounds; D004129:Dimethylpolysiloxanes; D001546:Bentonite; C013830:baysilon; D006493:Heparin; D000077286:Cetrimonium
Blood compatibility; Films; Heparin; Na(+)-montmorillonite; Poly(dimethylsiloxane) (PDMS); Solution intercalation