Hikiokoshins A-I, diterpenes from the leaves of Isodon japonicus.
Diterpenes, hikiokoshins A-I, and twelve known diterpenes were isolated from the leaves of Isodon japonicus (Burm. f.) H. Hara (Lamiaceae). The hikiokoshins A-I possess various skeletons such as ternifonane {hikiokoshin A}, ent-6,7:8,15-diseco-6,8-cyclokauran-7,20-olide {hikiokoshin B}, ent-6,7-secokauran-7,20-olide {hikiokoshin C}, and ent-7,20-epoxykaurane {hikiokoshins D-I}. Their structures were elucidated on the basis of spectroscopic analysis. Antimicrobial activities of hikiokoshins A and B were evaluated.
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Naonobu
N
Tanaka
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Eri
E
Tsuji
Medicinal Mycology Research Center, Chiba University, Chiba 260-0856, Japan.
Kanae
K
Sakai
Medicinal Mycology Research Center, Chiba University, Chiba 260-0856, Japan.
Tohru
T
Gonoi
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. Electronic address: jkobay@pharm.hokudai.ac.jp.
Jun'ichi
J
Kobayashi
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D051379:Mice; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004224:Diterpenes
Diterpenes; Hikiokoshins A–I; Isodon japonicus; Lamiaceae