Rates of β-amyloid accumulation are independent of hippocampal neurodegeneration.
OBJECTIVE
To test the hypotheses predicted in a hypothetical model of Alzheimer disease (AD) biomarkers that rates of β-amyloid (Aβ) accumulation on PET imaging are not related to hippocampal neurodegeneration whereas rates of neurodegenerative brain atrophy depend on the presence of both amyloid and neurodegeneration in a population-based sample.


METHODS
A total of 252 cognitively normal (CN) participants from the Mayo Clinic Study of Aging had 2 or more serial visits with both amyloid PET and MRI. Subjects were classified into 4 groups based on baseline positive/negative amyloid PET (A+ or A-) and baseline hippocampal volume (N+ or N-). We compared rates of amyloid accumulation and rates of brain atrophy among the 4 groups.


RESULTS
At baseline, 148 (59%) were amyloid negative and neurodegeneration negative (A-N-), 29 (12%) amyloid negative and neurodegeneration positive (A-N+), 56 (22%) amyloid positive and neurodegeneration negative (A+N-), and 19 (8%) amyloid positive and neurodegeneration positive (A+N+). High rates of Aβ accumulation were found in those with abnormal amyloid at baseline and were not influenced by hippocampal neurodegeneration at baseline. In contrast, rates of brain atrophy were greatest in A+N+.


CONCLUSIONS
We describe a 2-feature biomarker approach to classifying elderly CN subjects that is complementary to the National Institute on Aging-Alzheimer's Association preclinical staging criteria. Our results support 2 key concepts in a model of the temporal evolution of AD biomarkers. First, the rate of Aβ accumulation is not influenced by neurodegeneration and thus may be a biologically independent process. Second, Aβ pathophysiology increases or catalyzes neurodegeneration.
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G., V.L., B.E.G.), Health Sciences Research (H.J.W., M.M.M., S.D.W., V.S.P.), and Neurology (D.S.K., R.C.P.), Mayo Clinic and Foundation, Rochester, MN.
Clifford R
CR
Jack
Heather J
HJ
Wiste
David S
DS
Knopman
Prashanthi
P
Vemuri
Michelle M
MM
Mielke
Stephen D
SD
Weigand
Matthew L
ML
Senjem
Jeffrey L
JL
Gunter
Val
V
Lowe
Brian E
BE
Gregg
Vernon S
VS
Pankratz
Ronald C
RC
Petersen
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001284:Atrophy; D003072:Cognition Disorders / Q000175:diagnosis; D005260:Female; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D016014:Linear Models; D008297:Male; D009410:Nerve Degeneration / Q000000981:diagnostic imaging / Q000473:pathology*; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D015898:Tomography Scanners, X-Ray Computed
D016229:Amyloid beta-Peptides