Development of retinal layers.
A noticeable characteristic of nervous systems is the arrangement of synapses into distinct layers. Such laminae are fundamental for the spatial organisation of synaptic connections transmitting different kinds of information. A major example of this is the inner plexiform layer (IPL) of the vertebrate retina, which is subdivided into at least ten sublayers. Another noticeable characteristic of these retina layers is that neurons are displayed in the horizontal plane in a non-random array termed as mosaic patterning. Recent studies of vertebrate and invertebrate systems have identified molecules that mediate these interactions. Here, we review the last mechanisms and molecules mediating retinal layering.
Institut national de la santé et de la recherche médicale, UMR S968, CNRS UMR 7210, Université Pierre et Marie Curie (Paris-6), Institut de la vision, 17, rue Moreau, 75012 Paris, France.
Kim Tuyen
KT
Nguyen-Ba-Charvet
Institut national de la santé et de la recherche médicale, UMR S968, CNRS UMR 7210, Université Pierre et Marie Curie (Paris-6), Institut de la vision, 17, rue Moreau, 75012 Paris, France. Electronic address: Alain.Chedotal@inserm.fr.
Alain
A
Chédotal
D000818:Animals; D006801:Humans; D007448:Invertebrates / Q000502:physiology; D051379:Mice; D012160:Retina / Q000033:anatomy & histology / Q000254:growth & development* / Q000502:physiology; D013569:Synapses / Q000502:physiology
Couche plexiforme externe; Couche plexiforme interne; Inner plexiform layer; Mosaic; Mosaïque; Outer plexiform layer; Retina; Rétine; Stratification