The effects of whole green tea infusion on mouse urinary bladder chemical carcinogenesis.
OBJECTIVE
Green tea (GT) is one of the most popular beverages worldwide whose beneficial effects on health have been demonstrated. Recent studies suggest that GT may contribute to reduction of cancer risk and progression. The aim of this study was to evaluate the effects of whole GT on urinary bladder chemical carcinogenesis in male and female ICR mice.


METHODS
The GT characterization was performed using spectrophotometric methods. Urinary bladder lesions were induced using N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) by gavage during 10 weeks and whole GT (0.5%) was provided ad libitum during 20 weeks.


RESULTS
Animals from groups BBN+GT and BBN only developed preneoplastic lesions.


CONCLUSIONS
We did not observe any effects by GT infusion administration on urinary bladder cancer development.
Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Andreia
A
Henriques
Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Regina
R
Arantes-Rodrigues
Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Ana
A
I Faustino-Rocha
Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Catarina
C
I Teixeira-Guedes
Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Jacinta
J
Pinho-Oliveira
Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Daniela
D
Talhada
Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
José
J
H Teixeira
Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Andreia
A
Andrade
Department of Zootechnics, University of Trás-os-Montes and Alto Douro, 911 Vila Real, Portugal ; Center for the Study of Animal Sciences (CECA), University of Porto, 4485-661, Porto, Portugal ; Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Bruno
B
Colaço
Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Maria
M
N Paiva-Cardoso
Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal ; Center for the Study of Animal Sciences (CECA), University of Porto, 4485-661, Porto, Portugal ; Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Maria
M
J Pires
Chemistry Research Center, CQ-VR, University of Trás-os-Montes and Alto Douro, 5001-801, Vila Real, Portugal.
Ana
A
Mvd Ferreira
Chemistry Research Center, CQ-VR, University of Trás-os-Montes and Alto Douro, 5001-801, Vila Real, Portugal.
Fernando
F
M Nunes
Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal ; Center for the Study of Animal Sciences (CECA), University of Porto, 4485-661, Porto, Portugal ; Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
Paula
P
A Oliveira
Green tea; Mice; N-butyl-N-(4-hydroxybutyl)nitro- samine; Urinary bladder cancer