Relationships of indoleamine 2,3-dioxygenase activity and cofactors with asthma and nasal polyps.
BACKGROUND
Asthma and chronic rhinosinusitis with nasal polyps (CRSwNPs) are coexisting diseases that are multifactorial. The rural environment seems to protect from atopy, but its relation with nonatopic airway inflammations has been less investigated. Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in the catabolism of the essential amino acid tryptophan (Trp) to kynurenine (Kyn). Low IDO activity has been previously observed in atopy and asthma. The objective was to investigate the relationships of IDO activity, eosinophils, and cofactors during asthma and/or CRSwNPs.


METHODS
A Finnish population-based cohort of adult asthmatic patients (n = 245) and nonasthmatic patients (n = 405) was used. The presence of asthma and atopy were based on patient history and standardized diagnostic tests. The presence of acetyl salicylic acid intolerance, doctor-diagnosed NPs, and countryside environment during childhood were based on a questionnaire report. Serum IDO activity was evaluated by assessing the Kyn/Trp ratio by liquid chromatography.


RESULTS
Low IDO activity was associated significantly with atopy, CRSwNPs, and an urban background. IDO activity did not correlate with pulmonary function. As expected, CRSwNPs was more frequent among asthmatic patients. A rural background has a protective effect from atopy and atopic asthma but it did not affect the prevalence of CRSwNPs or nonatopic asthma.


CONCLUSIONS
Low IDO activity might result from the urban environment and influence the development of the atopic phenotype. On the other hand, low IDO activity, found in CRSwNPs, does not seem to be related to the urban background and thus may result from other, still unknown, factors.
Department of Clinical Medicine, Finn-Medi III, University of Tampere, Tampere, Finland.
Annika
A
Luukkainen
Jussi
J
Karjalainen
Mikko
M
Hurme
Timo
T
Paavonen
Heini
H
Huhtala
Sanna
S
Toppila-Salmi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000201:enzymology* / Q000276:immunology; D002853:Chromatography, Liquid; D002908:Chronic Disease; D015331:Cohort Studies; D004804:Eosinophils / Q000276:immunology; D005260:Female; D005387:Finland; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000097:blood*; D007737:Kynurenine / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000201:enzymology* / Q000276:immunology; D012220:Rhinitis / Q000201:enzymology* / Q000276:immunology; D012424:Rural Population; D012852:Sinusitis / Q000201:enzymology* / Q000276:immunology; D014364:Tryptophan / Q000378:metabolism
D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007737:Kynurenine; D014364:Tryptophan