Co-inheritance of mild hemophilia A and heterozygosity for type 2N von Willebrand disease: a diagnostic and therapeutic challenge.
Hemophilia A and von Willebrand disease are the two most common inherited bleeding disorders. Despite their frequency, however, there are very few reports of co-inheritance of the two disorders. We present the first report of a patient with mild hemophilia A and heterozygosity for type 2N von Willebrand disease (VWD). We discuss the patient's phenotype and highlight the diagnostic and therapeutic challenges caused by this co-inheritance.
Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas.
Holly
H
Lindsay
Katie
K
Bergstrom
Lakshmi
L
Srivaths
D002675:Child, Preschool; D005169:Factor VIII / Q000235:genetics; D006467:Hemophilia A / Q000150:complications / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008297:Male; D010641:Phenotype; D056728:von Willebrand Disease, Type 2 / Q000150:complications / Q000235:genetics*; D014841:von Willebrand Factor / Q000235:genetics
D014841:von Willebrand Factor; D005169:Factor VIII
bleeding disorders; hemophilia A; type 2N; von Willebrand disease