Thrombocytopenia induced by diazoxide in a patient with an insulinoma.
A 24-year-old healthy woman presented at our hospital due to hypoglycemia. A fasting test provoked spontaneous hypoglycemia, and contrast-enhanced abdominal computed tomography revealed a pancreatic tumor. We diagnosed her with insulinoma and initiated diazoxide treatment to prevent hypoglycemia. After 13 days of treatment, she experienced nasal bleeding, and her platelet count decreased from 186,000 /μL to 28,000 /μL. The thrombocytopenia was ameliorated five days after diazoxide was discontinued. Although diazoxide has hyperglycemic effects associated with decreased insulin secretion, diazoxide-induced thrombocytopenia is rare. A complete blood count should be obtained periodically in patients receiving treatment with diazoxide.
Department of Internal Medicine, Yokohama City Minato Red Cross Hospital, Japan.
Junichiro
J
Adachi
Makiyo
M
Mimura
Isao
I
Minami
Kazuhiko
K
Kakihana
Takayuki
T
Watanabe
D001706:Biopsy; D003937:Diagnosis, Differential; D003981:Diazoxide / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007340:Insulinoma / Q000188:drug therapy*; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed; D014665:Vasodilator Agents / Q000009:adverse effects / Q000627:therapeutic use; D055815:Young Adult
D014665:Vasodilator Agents; D003981:Diazoxide