Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids.
Peroxidation of membranes and lipoproteins converts "inert" phospholipids into a plethora of oxidatively modified phospholipids (oxPL) that can act as signaling molecules. In this review, we will discuss four major classes of oxPL: mildly oxygenated phospholipids, phospholipids with oxidatively truncated acyl chains, phospholipids with cyclized acyl chains, and phospholipids that have been oxidatively N-modified on their headgroups by reactive lipid species. For each class of oxPL we will review the chemical mechanisms of their formation, the evidence for their formation in biological samples, the biological activities and signaling pathways associated with them, and the catabolic pathways for their elimination. We will end by briefly highlighting some of the critical questions that remain about the role of oxPL in physiology and disease.
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, United States. Electronic address: sean.davies@vanderbilt.edu.
Sean S
SS
Davies
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, United States.
Lilu
L
Guo
D000818:Animals; D006801:Humans; D015227:Lipid Peroxidation; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
D010743:Phospholipids
CD36; Lipid aldehydes; Lipid peroxidation; Oxidized phospholipids; Platelet-activating factor acetyl hydrolase; Toll-like receptors