Genetics and mechanisms of ovarian cancer: parallels between Drosophila and humans.
Considering the degree of detail available at the genetic and cellular levels, the Drosophila ovary stands out as a powerful system to identify new players in the regulation of key aspects of cancer progression. In this review, we will comment on how the use of the Drosophila ovary has helped to elucidate some of the molecular bases of ovarian malignancies and to identify and characterize critical tumour suppressor genes and oncogenes with an impact in human pathologies.
Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/CSIC/JA, Carretera de Utrera km 1, 41013 Sevilla, Spain.
Alicia E
AE
Rosales-Nieves
Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/CSIC/JA, Carretera de Utrera km 1, 41013 Sevilla, Spain. Electronic address: agonrey@upo.es.
Acaimo
A
González-Reyes
D000818:Animals; D002465:Cell Movement / Q000235:genetics* / Q000502:physiology; D004330:Drosophila; D004848:Epithelium / Q000378:metabolism*; D005260:Female; D006801:Humans; D009857:Oncogenes / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D010053:Ovary / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
Border cell migration; Follicular epithelium; Hippo pathway; Ovarian carcinoma; Ovarian surface epithelium