Synthesis of 3-mono-substituted binaphthyl-based secondary amine catalysts via monobromination of an axially chiral dicarboxylic acid derivative.
A facile synthetic route to a 3-bromo binaphthyl-based secondary amine through the monobromination of an axially chiral dicarboxylic acid derivative has been developed. The combination of this new procedure with coupling reactions established an efficient synthetic approach to a series of binaphthyl-based secondary amine catalysts containing various functional groups in an efficient way.
Department of Chemistry, Graduate School of Science, Kyoto University , Sakyo, Kyoto 606-8502, Japan.
Taichi
T
Kano
Momotaro
M
Takeda
Ryu
R
Sakamoto
Keiji
K
Maruoka