Galactosylated bovine serum albumin nanoparticles for parenteral delivery of oridonin: tissue distribution and pharmacokinetic studies.
Bovine serum albumin (BSA) nanoparticle is a promising drug carrier system. Oridonin (ORI)-loaded galactosylated BSA nanoparticle (ORI-GB-NP) was prepared for liver targeting delivery of ORI. This work was designed to investigate the in vitro release, in vivo pharmacokinetics and tissue distribution of ORI-GB-NP. ORI-GB-NP was prepared by the desolvation method. The particle size of ORI-GB-NP was 172.0 ± 8.3 nm with narrow size distribution. The in vitro release of ORI-GB-NP exhibited biphasic drug release pattern with an initial burst release and consequently sustained release. Pharmacokinetic analysis displayed that ORI-GB-NP and ORI-loaded BSA nanoparticle (ORI-BSA-NP) could enhance the drug plasma level and prolong the circulation time in contrast with ORI solution. Meanwhile, compared with ORI-BSA-NP, ORI-GB-NP could deliver more ORI to liver and simultaneously reduce the toxicity of ORI to heart, lung and kidney. In conclusion, ORI-GB-NP could be a promising drug delivery system for liver cancer therapy.
Department of Pharmaceutics, College of Pharmacy, Shandong University , Jinan , PR China.
Caiyun
C
Li
Dianrui
D
Zhang
Yuanyuan
Y
Guo
Hejian
H
Guo
Tingting
T
Li
Leilei
L
Hao
Dandan
D
Zheng
Guangpu
G
Liu
Qiang
Q
Zhang
D000818:Animals; D002417:Cattle; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D007263:Infusions, Parenteral; D053758:Nanoparticles / Q000737:chemistry*; D009928:Organ Specificity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
D003692:Delayed-Action Preparations; D045786:Diterpenes, Kaurane; C011959:oridonin; D012710:Serum Albumin, Bovine
Bovine serum albumin nanoparticles; galactosylated; oridonin; pharmacokinetics; tissue distribution