Effect of frequent application of low-level laser therapy on corticotomized tooth movement in dogs: a pilot study.
OBJECTIVE
The purposes of the present study were to evaluate the effects of frequent applications of low-level laser therapy (LLLT) on corticotomy-assisted tooth movement in a beagle dog model and to compare the effects in the mandible and maxilla.


METHODS
In 4 male beagles, the maxillary and mandibular second premolars were extracted. The third premolars were corticotomized and then protracted from the canines with a continuous force of 200 g. Daily LLLT (using an aluminum gallium indium phosphide [AlGaInP] diode) was applied at the buccal mucosa of the corticotomized premolars on 1 side only. The tooth movement was measured for 8 weeks. Fluorochromes were injected intravenously at the start of the experiment (T0) and after 2 (T2), 4 (T4), and 8 (T8) weeks to evaluate new bone formation on the tension sides. Histomorphometric and immunohistologic evaluations were performed.


RESULTS
In the mandible, the movement of the corticotomized premolars in the LLLT plus corticotomy group was less than that in the corticotomy-only group, although the difference was not statistically significant. In the maxilla, no significant differences between the 2 groups were found. Osteoclastic and proliferating cell activities and the amount of new bone formation were greater in the mandibular LLLT plus corticotomy group than in the corticotomy-only group.


CONCLUSIONS
The frequent application of LLLT showed no significant effect on the corticotomized tooth movement.
Private Practitioner, Former Graduate Student, Graduate School of Clinical Dental Science, The Catholic University of Korea, Seoul, Korea.
Kwang Heung
KH
Han
Associate Professor and Chair, Postgraduate Orthodontic Program, Arizona School of Dentistry & Oral Health, A.T. Still University, Mesa, AZ; and Adjunct Professor, the Graduate School of Dentistry, Kyung Hee University, Seoul, Korea.
Jae Hyun
JH
Park
Research Assistant Professor, Department of Dentistry, The Catholic University of Korea, Seoul, Korea; and Visiting Professor, Department of Postgraduate Studies, Universidad Autonóma del Paraguay, Asunción, Paraguay.
Mohamed
M
Bayome
Private Practitioner, Seoul, Korea.
In-Seong
IS
Jeon
Professor, Oral and Maxillofacial Surgery, Department of Dentistry, Uijeongbu St Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, GyeongGi, Korea.
Won
W
Lee
Professor, Department of Orthodontics, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address: kook190036@yahoo.com.
Yoon-Ah
YA
Kook
D000135:Acid Phosphatase / Q000032:analysis; D000539:Alveolar Process / Q000528:radiation effects / Q000601:surgery; D000818:Animals; D000880:Anthraquinones; D001641:Bicuspid / Q000528:radiation effects / Q000601:surgery; D001862:Bone Resorption / Q000145:classification; D049109:Cell Proliferation / Q000528:radiation effects; D004285:Dogs; D005452:Fluoresceins; D005456:Fluorescent Dyes; D007527:Isoenzymes / Q000032:analysis; D054023:Lasers, Semiconductor / Q000627:therapeutic use; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D008334:Mandible / Q000528:radiation effects / Q000601:surgery*; D008437:Maxilla / Q000528:radiation effects / Q000601:surgery; D023421:Models, Animal; D009969:Orthodontic Wires; D010010:Osteoclasts / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology / Q000528:radiation effects; D010865:Pilot Projects; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D012391:Root Resorption / Q000145:classification; D000071681:Tartrate-Resistant Acid Phosphatase; D013752:Tetracycline; D013997:Time Factors; D014087:Tooth Movement Techniques / Q000295:instrumentation / Q000379:methods*
D000880:Anthraquinones; D005452:Fluoresceins; D005456:Fluorescent Dyes; D007527:Isoenzymes; D018809:Proliferating Cell Nuclear Antigen; C010078:alizarin; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D013752:Tetracycline; C007740:fluorexon