Assessment of micronuclei and sister chromatid exchange frequency in the petroleum industry workers in province of Vojvodina, Republic of Serbia.
Persons who work with petroleum and petroleum derivatives (PPD) are potentially at risk of developing cancer mostly due to the carcinogenity of benzene. Therefore, the aim of this study was to determine in which degree occupational exposure of workers to PPD causes damage to DNA by analysis of micronuclei (MN), sister chromatid exchanges (SCE) and proliferation index (PI). 30 workers of refinery in Novi Sad, participated in the study as exposed and 30 volunteers as control group. Workers exposed to PPD had significantly higher values of MN and SCE in comparison to controls. Exposition time to PPD and type of working place have also significantly effects to DNA damage. The influence of confounding factor such as smoking and age were also evaluated.
Oncology Institute of Vojvodina, Experimental Oncology Department, Put Dr Goldmana 4, 21204 Sremska Kamenica, Serbia.
Jasminka
J
Mrdjanović
Oncology Institute of Vojvodina, Experimental Oncology Department, Put Dr Goldmana 4, 21204 Sremska Kamenica, Serbia.
Slavica
S
Šolajić
University of Kragujevac, Faculty of Science, Radoja Domanovića 12, Kragujevac, Serbia.
Sladjana
S
Dimitrijević
Oncology Institute of Vojvodina, Experimental Oncology Department, Put Dr Goldmana 4, 21204 Sremska Kamenica, Serbia.
Igor
I
Đan
Oncology Institute of Vojvodina, Experimental Oncology Department, Put Dr Goldmana 4, 21204 Sremska Kamenica, Serbia.
Ivan
I
Nikolić
University of Kragujevac, Faculty of Medical Science, P.O. Box 124, 34000 Kragujevac, Serbia. Electronic address: vdvd@mailcity.com.
Vladimir
V
Jurišić
D000328:Adult; D016022:Case-Control Studies; D004249:DNA Damage / Q000235:genetics; D019652:Extraction and Processing Industry; D006801:Humans; D015162:Micronucleus Tests; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D010578:Petroleum; D055771:Serbia; D012854:Sister Chromatid Exchange; D012907:Smoking / Q000009:adverse effects; D013997:Time Factors; D055815:Young Adult
D010578:Petroleum
Cigarette smoking; Micronuclei; Petroleum refinery; Proliferative index; Risk; Sister chromatid exchange