Sizing up models of heart failure: Proteomics from flies to humans.
Cardiovascular disease is the leading cause of death in the western world. Heart failure is a heterogeneous and complex syndrome, arising from various etiologies, which result in cellular phenotypes that vary from patient to patient. The ability to utilize genetic manipulation and biochemical experimentation in animal models has made them indispensable in the study of this chronic condition. Similarly, proteomics has been helpful for elucidating complicated cellular and molecular phenotypes and has the potential to identify circulating biomarkers and drug targets for therapeutic intervention. In this review, the use of human samples and animal model systems (pig, dog, rat, mouse, zebrafish, and fruit fly) in cardiac research is discussed. Additionally, the protein sequence homology between these species and the extent of conservation at the level of the phospho-proteome in major kinase signaling cascades involved in heart failure are investigated.
Department of Medicine, Division of Cardiology, The Johns Hopkins University, Baltimore, MD, USA.
Viola
V
Kooij
Vidya
V
Venkatraman
John
J
Tra
Jonathan A
JA
Kirk
Janelle
J
Rowell
Anna
A
Blice-Baum
Anthony
A
Cammarato
Jennifer E
JE
Van Eyk
D000818:Animals; D004195:Disease Models, Animal; D004330:Drosophila; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D040901:Proteomics; D015027:Zebrafish
Animal models; Heart failure; Posttranslational modifications