A new diketopiperazine from South China Sea marine sponge Callyspongia sp.
Further chemical investigation on the marine sponge Callyspongia sp. collected from South China Sea led to the isolation of a new diketopiperazine, named callysponine A (1), as well as four known diketopiperazines, namely cyclo-(Gly-Pro) (2), cyclo-(Thr-Pro) (3), cyclo-(Ile-Pro) (4) and cyclo-(Pro-Pro) (5). The new structure was determined on the basis of NMR and MS analysis, and the absolute stereochemistry was defined by analysis of the coupling constants and optical rotation. The structures of the known compounds were identified by comparing their spectroscopic data with those reported in the literature. Compounds 1-5 did not inhibit the growth of HepG2 (hepatoma carcinoma cell), A549 (lung carcinoma cell) and HeLa (cervical cancer cell) cell lines.
a Key Laboratory of Plant Resource Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510-650 , China.
Yinning
Y
Chen
Yan
Y
Peng
Chenghai
C
Gao
Riming
R
Huang
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047128:Callyspongia / Q000737:chemistry*; D002681:China; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; D054659:Diketopiperazines; D010456:Peptides, Cyclic; C000592869:callysponine A; C062238:cyclo(prolylglycyl)
Callyspongia sp.; callysponine A; diketopiperazine