Apo B/Apo A-I Ratio is Statistically A Better Predictor of Cardiovascular Disease (CVD) than Conventional Lipid Profile: A Study from Kathmandu Valley, Nepal.
BACKGROUND
Apo B and Apo A-I, are structural and functional components of lipoprotein particles that serve as transporters of cholesterol. The apo B/apo A-I ratio reflects the cholesterol transport and has been shown to be strongly related to risk of Myocardial infarction, stroke and other Cardiovascular manifestations.


METHODS
Forty five participants with Cardiovascular Disease (CVD) and forty four healthy participants were included from different locations of Kathmandu valley, Nepal. Fasting blood samples were collected from ante-cubital vein and serum samples were used for lipid parameters, apo B and apo A-I levels measurement.


RESULTS
Statistically significant differences were found for apo B/apo A-I ratio, HDL-c and apo B between the groups. The other lipid parameters and lipid ratios such as total cholesterol, triglyceride, low density lipoprotein, TC/HDL-c, TG/HDL-c and LDL-c/HDL-c were not found to be significant.


CONCLUSIONS
Apo B/apo A-I ratio seems to have better predictive value than that of classical lipid parameters in cardiovascular risk assessment.
Lecturer, Department of Biochemistry, Kantipur Dental College Teaching Hospital , Dhapasi, Basundhara, Kathamandu, Nepal .
Hem Kumar
HK
Tamang
Phd Scholar, Department of Life Sciences and Biotechnology, South Asian University , New Delhi, India .
Uddhav
U
Timilsina
Lecturer, Department of Biochemistry, Institute of Medicine (TUTH) , Maharajgunj, Kathmandu, Nepal .
Khelanand Prasad
KP
Singh
Medical Laboratory Technologist, Department of Pathology, Kathmandu Model Hospital , Exhibition Road, Kathmandu, Nepal .
Sanjit
S
Shrestha
Lecturer, Department of Anatomy, Kantipur Dental college Teaching Hospital , Dhapasi, Basundhara, Kathmandu, Nepal .
Ramendra Kumar
RK
Raman
Faculty, Department of Medical Laboratory Technology, Nobel College , Sinamangal, Kathmandu, Nepal .
Pujan
P
Panta
Faculty, Department of Medical Laboratory Technology, Nobel College , Sinamangal, Kathmandu, Nepal .
Preeti
P
Karna
Faculty, Department of Medical Laboratory Technology, Nobel College , Sinamangal, Kathmandu, Nepal .
Laxmi
L
Khadka
Faculty, Department of Medical Laboratory Technology, Nobel College , Sinamangal, Kathmandu, Nepal.
Chandika
C
Dahal
Apo B/apo A-I ratio; Cardiovascular disease; Lipid parameters; Predictive value