Evaluation of PUVA-Induced Skin Side Effects in Patients Referred to the Imam Reza Hospital of Mashhad in 2005-2007.
BACKGROUND
Systemic oral psoralens plus UVA therapy (PUVA) is a therapeutic method used with considerable success in many different skin disorders. PUVA therapy causes some cutaneous and noncutaneous side effects and in the present research we deal with cutaneous side effects.


OBJECTIVE
Evaluation of patients to know the different skin side effects of PUVA and their importance.


METHODS
All patients referred to the phototherapy unit of Imam Reza Hospital of Mashhad entered the research and skin examination was taken place initially and every 3 months thereafter. Whenever any side effect appeared, it was recorded in the information sheet.


RESULTS
One hundred and twenty-eight patients were included in the research, 61 were male between 15 and 75 years and 67 were female between 10 and 61 years of age. Age of female patients at the time of cutaneous side effect appearance was less than male patients. The most common early side effect was pruritus (34.3%) and the rarest was telangiectasia (0.7%). One case of late side effect in the form of squamous cell carcinoma was observed in a patient who had received other carcinogenic drugs as well. Complications such as skin dryness, pruritus, erythema and burning sensation occurred at low doses of UVA, while dermatitis, severe limb pain and acne at moderate doses and PUVA lentigines, hypertrichosis and lichenoid lesions appeared at high doses of UVA.


CONCLUSIONS
Considering the significant therapeutic effects and few serious side effects, PUVA therapy is a suitable and safe method for treatment of certain skin diseases.
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Masoud
M
Maleki
Research Center for Skin Diseases and Cutaneous Leishmaniasis, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Javad
MJ
Yazdanpanah
Department of Dermatology, Arak University of Medical Sciences, Arak, Iran.
Hamid
H
Hamidi
Department of Dentistry, Arak University of Medical Sciences, Arak, Iran.
Leila
L
Jokar
Lentigines; Psoralen plus UVA; side effect