Two new cytotoxic indole alkaloids from a deep-sea sediment derived metagenomic clone.
Two new indole alkaloids, metagenetriindole A (1) and metagenebiindole A (2), were identified from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth. The structures of new compounds were elucidated by spectroscopic methods. The two new indole alkaloids demonstrated moderately cytotoxic activity against CNE2, Bel7402 and HT1080 cancer cell lines in vitro.
Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China. 420912769@qq.com.
Xia
X
Yan
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography State Oceanic Administration, Xiamen 361005, China. tangxixiang@hotmail.com.
Xi-Xiang
XX
Tang
Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China. chenlin13405@126.com.
Lin
L
Chen
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography State Oceanic Administration, Xiamen 361005, China. xyxyyzw@163.com.
Zhi-Wei
ZW
Yi
Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China. fangmj@xmu.edu.cn.
Mei-Juan
MJ
Fang
Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China. wuzhen@xmu.edu.cn.
Zhen
Z
Wu
Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China. qyk@xmu.edu.cn.
Ying-Kun
YK
Qiu
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003001:Cloning, Molecular; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000235:genetics*; D005285:Fermentation; D019015:Geologic Sediments / Q000382:microbiology; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D056186:Metagenomics
D000970:Antineoplastic Agents; D026121:Indole Alkaloids