Oxidative stress induced in nurses by exposure to preparation and handling of antineoplastic drugs in Mexican hospitals: a multicentric study.
The impact of involuntary exposure to antineoplastic drugs (AD) was studied in a group of nurses in diverse hospitals in Mexico. The results were compared with a group of unexposed nurses. Anthropometric characteristics and the biochemical analysis were analyzed in both groups. Also, lipid peroxidation level (LPX), protein carbonyl content (PCC), and activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated in blood of study participants as oxidative stress (OS) biomarkers. The group of occupationally exposed (OE) nurses consisted of 30 individuals ranging in age from 25 to 35 years. The control group included 30 nurses who were not occupationally exposed to the preparation and handling of AD and whose anthropometric and biochemical characteristics were similar to those of the OE group. All biomarkers evaluated were significantly increased (P < 0.5) in OE nurses compared to the control group. Results show that the assessment of OS biomarkers is advisable in order to evaluate exposure to AD in nurses.
Laboratorio de Toxicología Ambiental, Facultad de Química, Universidad Autónoma del Estado de México, 50120 Toluca, MEX, Mexico.
Leobardo Manuel
LM
Gómez-Oliván
Laboratorio de Toxicología Ambiental, Facultad de Química, Universidad Autónoma del Estado de México, 50120 Toluca, MEX, Mexico.
Gerardo Daniel
GD
Miranda-Mendoza
Centro Oncológico Estatal del Instituto de Seguridad Social del Estado de México y Municipios, 50180 Toluca, MEX, Mexico.
Paula Anel
PA
Cabrera-Galeana
Laboratorio de Toxicología Acuática, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 07700 México, DF, Mexico.
Marcela
M
Galar-Martínez
Laboratorio de Toxicología Ambiental, Facultad de Química, Universidad Autónoma del Estado de México, 50120 Toluca, MEX, Mexico.
Hariz
H
Islas-Flores
Laboratorio de Toxicología Ambiental, Facultad de Química, Universidad Autónoma del Estado de México, 50120 Toluca, MEX, Mexico.
Nely
N
Sanjuan-Reyes
Laboratorio de Toxicología Ambiental, Facultad de Química, Universidad Autónoma del Estado de México, 50120 Toluca, MEX, Mexico.
Nadia
N
Neri-Cruz
Laboratorio de Toxicología Acuática, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 07700 México, DF, Mexico.
Sandra
S
García-Medina
D000328:Adult; D000886:Anthropometry; D000970:Antineoplastic Agents / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D003710:Demography; D005260:Female; D006761:Hospitals; D006801:Humans; D008800:Mexico; D009726:Nurses; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D018384:Oxidative Stress / Q000187:drug effects*; D013048:Specimen Handling
D000970:Antineoplastic Agents; D015415:Biomarkers