Post-translational modification of transcription factors: mechanisms and potential therapeutic interventions.
Transcription factors (TFs) orchestrate multiple cellular processes through tight regulation via post-translational modifications (PTMs). Thus, decoding the combinations of PTMs should provide critical layer of information that can be integrated into highly specific cellular outputs to reveal a network of genes and their target-specific regulation. Protein modifications play a decisive role in various drug responses and eventually in prognosis for many life-threatening diseases, and recent studies demonstrate that TF-based drug designing must consider structural and functional changes due to PTMs, yet we are just beginning to grasp this enormity and the impact on normal development and disease pathophysiology.
Sonia L
SL
Planey
Raj
R
Kumar
Basic Sciences, The Commonwealth Medical College, 525 Pine Street, Scranton, PA 18509, USA. jarnott@tcmedc.org.
John A
JA
Arnott
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*
D014157:Transcription Factors