The peptide Z-Aib-Aib-Aib-L-Ala-OtBu.
The title peptide, N-benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyryl-α-aminoisobutyryl-L-alanine tert-butyl ester or Z-Aib-Aib-Aib-L-Ala-OtBu (Aib is α-aminoisobutyric acid, Z is benzyloxycarbonyl and OtBu indicates the tert-butyl ester), C27H42N4O7, is a left-handed helix with a right-handed conformation in the fourth residue, which is the only chiral residue. There are two 4→1 intramolecular hydrogen bonds in the structure. In the lattice, molecules are hydrogen bonded to form columns along the c axis.
IMBB/FORTH, 70013 Iraklion Crete, Greece.
Renate
R
Gessmann
Department of Food Sciences, Interdisciplinary Research Center, Justus Liebig University of Giessen, 35392 Giessen, Germany.
Hans
H
Brückner
IMBB/FORTH, 70013 Iraklion Crete, Greece.
Kyriacos
K
Petratos
D000409:Alanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D000595:Amino Acid Sequence; D000621:Aminoisobutyric Acids / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D009842:Oligopeptides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
D000621:Aminoisobutyric Acids; C000589433:N-benzyloxycarbonyl-alpha-aminoisobutyryl-alpha-aminoisobutyryl-alpha-aminoisobutyryl-L-alanine tert-butyl ester; D009842:Oligopeptides; D010455:Peptides; C100049:2-aminoisobutyric acid; D000409:Alanine
Aib-Aib-Aib-Ala; crystal structure; hydrogen bonding; left-handed helix; peptaibol antibiotic peptides; peptide; α-aminoisobutyric acid