Efficacy of ginseng adventitious root extract on hyperglycemia in streptozotocin-induced diabetic rats.
BACKGROUND
Ginseng has various bioactive effects on human health including its potential activity of improving the glucose homeostasis and insulin sensitivity.


METHODS
Tissue culture raised mountain ginseng adventitious root (TCMGARs) extract enriched with ginsenosides was used as experimental material. Streptozotocin-induced diabetic 'Sprague Dawley' male rats were used as experimental systems and were fed with Tissue culture raised mountain ginseng adventitious root extract. Field cultivated Korean ginseng root extract fed rats were used as positive control and several indices such as body weight, blood glucose level and other serological indicators were tested.


RESULTS
Chemical profile showed TCMGARs were rich in varied ginsenosides especially Rb1, Rb2, Rc, Rd, Rg3, and Rh2 when compared to field cultivated Korean ginseng. TCMGARs extract at dosage levels of 250 and 500 mg/kg body weight significantly lowered the blood glucose, total cholesterol and triglyceride content in streptozotocin-induced diabetic rats.


CONCLUSIONS
The data of in vivo experiments on anti-glycemic effects of TCMGARs proves their efficacy and also their use as dietary supplement.
Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju 361-763, Republic of Korea; Department of Botany, Karnatak University, Dharwad 580003, India. Electronic address: nmurthy60@yahoo.co.in.
Hosakatte Niranjana
HN
Murthy
Department of Botany, Karnatak University, Dharwad 580003, India.
Vijayalaxmi S
VS
Dandin
Cheongsol Biotech Co. Ltd., Industry Academic Cooperation Foundation Agribusiness Incubator Center, 205, Chungbuk National University, Cheongju 361-763, Republic of Korea.
Eun Jung
EJ
Lee
Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju 361-763, Republic of Korea; Cheongsol Biotech Co. Ltd., Industry Academic Cooperation Foundation Agribusiness Incubator Center, 205, Chungbuk National University, Cheongju 361-763, Republic of Korea. Electronic address: paekky@chungbuk.ac.kr.
Kee Yoeup
KY
Paek
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D036145:Ginsenosides / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D007004:Hypoglycemic Agents / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D005894:Panax; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D036145:Ginsenosides; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol
Antidiabetic; Blood glucose; Dietary supplement; Ginsenosides