Propionylcarnitine and methionine concentrations in newborns with hypospadias.
BACKGROUND
Of interest is if factors like maternal diet can influence the risk of hypospadias-affected pregnancy. Increased propionylcarnitine (C3) is regarded as a biomarker of vitamin B12 deficiency. The retrospective study was undertaken to determine whether increased propionylcarnitine and low methionine in newborns are associated with hypospadias.


METHODS
41 newborns with hypospadias and 90 control newborns without congenital anomalies were investigated. Whole blood propionylcarnitine and methionine concentrations were measured using tandem mass spectrometry.


RESULTS
The mean concentration of propionylcarnitine was higher in newborns with hypospadias compared with newborns without congenital anomalies (p = 0.026). The mean methionine level in cases was insignificantly lower than in controls.


CONCLUSIONS
There appears to be an association between decreased vitamin B12, as indexed by an increase of propionylcarnitine, and hypospadias in the investigated group of patients.
Department of Pediatric Surgery.
Andrzej
A
Kowal
Department of Pediatric Surgery.
Dariusz
D
Mydlak
Neonatal Screening Laboratory.
Mariusz
M
Ołtarzewski
Department of Pediatrics, Institute of Mother and Child, Warsaw, Poland.
Anna
A
Bauer
Department of Pediatric Surgery.
Ewa
E
Sawicka
Department of Pediatrics, Institute of Mother and Child, Warsaw, Poland.
Kamil K
KK
Hozyasz
MS/MS; hypospadias; methionine; propionylcarnitine; vitamin B12