A new benzyl ester and ergosterol derivatives from the fungus Gymnoascus reessii.
A new benzyl ester, reessiate (1), anthraquinone, islandicin (2), ergosterol and seven ergosterol derivatives (3-9) were isolated from the fungus Gymnoascus reessii. All structures were identified by spectroscopic methods. This is the first report of their isolation from this fungus. Compounds 4-7 and 9 exhibited antimalarial activity against Plasmodium falciparum with IC50 values in the range of 3.3-4.5 μg/mL. In addition, 4 showed cytotoxicity against KB, MCF7 and NCI-H187 cancer cell lines. It was found that 4 has cytotoxic effect to MCF7 (IC50 = 7.9 μg/mL) lower than Doxorubicin (IC50 = 8.5 μg/mL).
a Natural Products Research Unit, Department of Chemistry, and Center of Excellence for Innovation in Chemistry , Faculty of Science, Khon Kaen University , Khon Kaen 40002 , Thailand.
Sasiwimon
S
Kitchawalit
Kwanjai
K
Kanokmedhakul
Somdej
S
Kanokmedhakul
Kasem
K
Soytong
D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001593:Benzyl Compounds / Q000737:chemistry / Q000302:isolation & purification*; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004952:Esters; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*
D000880:Anthraquinones; D000962:Antimalarials; D001593:Benzyl Compounds; D004952:Esters; C000592817:reessiate; C015286:funiculosin (anthraquinone); D004875:Ergosterol
Gymnoascus reessii; antimalaria; benzyl ester; cytotoxicity; ergosterol derivative