In situ cross-linked polysaccharide hydrogel as extracellular matrix mimics for antibiotics delivery.
Many synthetic hydrogels for drug delivery have been based on polyethylene glycol which is non-natural, non-biodegradable and only terminal-functionalizable. The polysaccharides dextran and chitosan not only are highly hydrophilic, biodegradable and pendant-functionalizable, but also more closely mimic the nature extracellular matrix glycosaminoglycans. Here, a biomimetic hydrogel based on chitosan and dextran was synthesized by the Michael addition reaction. The hydrogels have good swelling and cytocompatibility against NIH3T3. Moreover, vancomycin-loaded hydrogels were formed in situ, and could kill both Gram-positive bacteria and Gram-negative bacteria, indicating that the hydrogel as a wound dressing could provide protection against bacterial infection. Notably, the drug release was controlled via modifying the compositions. Therefore, the biomimetic polysaccharide hydrogels as a promising carrier have potential application for wound healing.
Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.
Yu
Y
Zhao
Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China. Electronic address: zhangxinge@nankai.edu.cn.
Xinge
X
Zhang
Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.
Yanan
Y
Wang
Metabolic Disease Hospital, Tianjin Medical University, Tianjin 300070, China.
Zhongming
Z
Wu
Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.
Jinxia
J
An
Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.
Zhentan
Z
Lu
Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.
Lin
L
Mei
Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.
Chaoxing
C
Li
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry*; D040761:Biomimetic Materials / Q000008:administration & dosage / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D016503:Drug Delivery Systems / Q000379:methods*; D005109:Extracellular Matrix / Q000737:chemistry*; D051379:Mice; D041681:NIH 3T3 Cells; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D011134:Polysaccharides
Antibacterial; Hydrogel; Polysaccharide; Wound dressing