Decarboxylative arylation of α-amino acids via photoredox catalysis: a one-step conversion of biomass to drug pharmacophore.
The direct decarboxylative arylation of α-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically α-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components.
Merck Center for Catalysis, Princeton University , Princeton, New Jersey 08544, United States.
Zhiwei
Z
Zuo
David W C
DW
MacMillan
D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D003653:Decarboxylation; D008027:Light; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D055668:Photochemical Processes
D000596:Amino Acids