Progesterone receptor expression in sinonasal leiomyoma: a case report and review of the literature.
Leiomyomas are benign myogenic tumors that seldom occur in the sinonasal cavity. They were commonly found in middle-aged adults with a female predominance. Clinical symptoms include nasal obstruction with discharge, nasal bleeding and pain. We describe the case of a 48 year-old woman with a leiomyoma arising from right inferior nasal turbinate. Transnasal endoscopic excision was performed with satisfied result. The tumor was found to be progesterone receptor positive on immunohistochemical analysis. The clinical findings are addressed with a review of the literature. To the best of our knowledge, this is the third reported case that supports the growth of the tumor may be hormone-dependent.
Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital Changhua, Taiwan.
Pao-Yu
PY
Tseng
Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital Changhua, Taiwan.
Yu-Shih
YS
Lai
Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital Changhua, Taiwan ; Institute of Medicine, Chung Shan Medical University Taichung, Taiwan.
Mu-Kuan
MK
Chen
Department of Pathology, Changhua Christian Hospital Changhua, Taiwan.
Ko-Hung
KH
Shen
D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000378:metabolism* / Q000473:pathology*; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology*; D010255:Paranasal Sinus Neoplasms / Q000378:metabolism / Q000473:pathology; D011980:Receptors, Progesterone / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D011980:Receptors, Progesterone
Paranasal sinuses; angioleiomyoma; intranasal surgery; nasal cavity; progesterone receptor; sex hormone-binding globulin receptor