Surmounting retraining limits in musicians' dystonia by transcranial stimulation.
OBJECTIVE
Abnormal cortical excitability is evident in various movement disorders that compromise fine motor control. Here we tested whether skilled finger movements can be restored in musicians with focal hand dystonia through behavioral training assisted by transcranial direct current stimulation to the motor cortex of both hemispheres.


METHODS
The bilateral motor cortices of 20 pianists (10 with focal dystonia, 10 healthy controls) were electrically stimulated noninvasively during bimanual mirrored finger movements.


RESULTS
We found improvement in the rhythmic accuracy of sequential finger movements with the affected hand during and after cathodal stimulation over the affected cortex and simultaneous anodal stimulation over the unaffected cortex. The improvement was retained 4 days after intervention. Neither a stimulation with the reversed montage of electrodes nor sham stimulation yielded any improvement. Furthermore, the amount of improvement was positively correlated with the severity of the symptoms. Bihemispheric stimulation without concurrent motor training failed to improve fine motor control, underlining the importance of combined retraining and stimulation for restoring the dystonic symptoms. For the healthy pianists, none of the stimulation protocols enhanced movement accuracy.


CONCLUSIONS
These results suggest a therapeutic potential of behavioral training assisted by bihemispheric, noninvasive brain stimulation in restoring fine motor control in focal dystonia.
Institute for Music Physiology and Musicians' Medicine, Hanover University of Music, Drama, and Media, Hanover.
Shinichi
S
Furuya
Michael A
MA
Nitsche
Walter
W
Paulus
Eckart
E
Altenmüller
D000328:Adult; D004311:Double-Blind Method; D020821:Dystonic Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D005385:Fingers / Q000502:physiology; D006801:Humans; D007858:Learning / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D010865:Pilot Projects; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D055815:Young Adult