Cancer mouse models: past, present and future.
The development and advances in gene targeting technology over the past three decades has facilitated the generation of cancer mouse models that recapitulate features of human malignancies. These models have been and still remain instrumental in revealing the complexities of human cancer biology. However, they will need to evolve in the post-genomic era of cancer research. In this review we will highlight some of the key developments over the past decades and will discuss the new possibilities of cancer mouse models in the light of emerging powerful gene manipulating tools.
Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK. Electronic address: wtk22@cam.ac.uk.
Walid T
WT
Khaled
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK. Electronic address: pl2@sanger.ac.uk.
Pentao
P
Liu
D000818:Animals; D035843:Biomedical Research / Q000639:trends; D052138:Genes, Neoplasm; D006801:Humans; D008822:Mice, Transgenic; D009374:Neoplasms, Experimental / Q000235:genetics*
Cancer models; Cas9; Gene targeting; PDX; Transgenics