Association of SLC6A4 5-HTTLPR and TRPV1 945G>C with functional dyspepsia in Korea.
OBJECTIVE
The association of various genetic polymorphisms with functional dyspepsia (FD) has been suggested, but the results were still controversial. The aim of the present study was to assess the association of GNB3 825C>T, SLC6A4 5-HTTLPR, ADRA2A-1291C>G, CCK-1R intron 779T>C, and TRPV1 945G>C polymorphisms with FD based on Rome III criteria in Korea.


METHODS
Study subjects were prospectively recruited from visitors to Seoul National University Bundang Hospital between 2009 and 2012. One hundred and twelve FD patients and 269 controls were enrolled.


RESULTS
In SLC6A4 5-HTTLPR polymorphism, the frequency of S/S genotype was significantly lower than that of L/L + L/S genotype in FD compared to controls (P < 0.05). After stratification according to Helicobacter pylori infection, the S/S genotype was significantly associated with H. pylori-positive epigastric pain syndrome (EPS) patients (adjusted odds ratio (OR) 0.46; 95% confidence interval (CI) 0.22-0.99; P = 0.048). In TRPV1 945G>C polymorphism, the frequency of C/C genotype was lower in FD compared to controls (P = 0.057). The C carrier and C/C genotype was significantly associated with postprandial distress syndrome (PDS) and EPS, respectively (adjusted OR 0.47 and 0.43; 95% CI 0.25-0.90 and 0.20-0.93; P = 0.021 and 0.033). After stratification, the significant associations remained in H. pylori-positive PDS and EPS patients (adjusted OR 0.37 and 0.28; 95% CI 0.16-0.88 and 0.09-0.85; P = 0.024 and 0.025).


CONCLUSIONS
The genetic polymorphism of SLC6A4 5-HTTLPR and TRPV1 945G>C could be one of the pathophysiological factors of FD, especially in the case of H. pylori-positive patients in Korea.
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Gyeonggi-do, Korea.
Sung Wook
SW
Hwang
Nayoung
N
Kim
Hye-Kyung
HK
Jung
Ji Hyun
JH
Park
Yoon Jin
YJ
Choi
Heebal
H
Kim
Jaemin
J
Kim
Joo Sung
JS
Kim
Hyun Chae
HC
Jung
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004415:Dyspepsia / Q000235:genetics*; D005260:Female; D005756:Gastritis / Q000235:genetics / Q000382:microbiology; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies; D056910:Republic of Korea; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D050916:TRPV Cation Channels / Q000235:genetics*; D055815:Young Adult
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human
Helicobacter pylori; functional dyspepsia; polymorphism; single nucleotide polymorphism