Copper(II)-catalyzed carbon-carbon triple bond cleavage of internal alkynes for the synthesis of annulated indolizines.
Cleavage of C≡C bond in butynedioates via copper(II)-catalyzed reaction has been achieved, leading to the synthesis of benzo[f]pyrido[1,2-a]indole-6,11-diones in high yields by one-pot three-component reactions. In this unprecedented C≡C bond cleavage reaction of internal alkynes, both fragments from the alkyne are successively incorporated into the products.
Jiangsu Key Laboratory of Green Synthetic for Functional Materials and School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, Jiangsu, PR China.
Jinwei
J
Sun
Fuyao
F
Wang
Huayou
H
Hu
Xiangshan
X
Wang
Hui
H
Wu
Yun
Y
Liu