In vitro delivery of curcumin with cholesterol-based cationic liposomes.
A new cholesterol-based cationic lipid was synthesized; liposomes prepared on its basis were evaluated as drug delivery vehicles for curcumin. Free and liposome-encapsulated curcumin cytotoxicity against HeLa, A549, HepG2, K562 and 1301 cell lines was assessed. Liposomal curcumin with ED50 values ranging from 2.5-10 microM exhibited 2-8 times higher cytotoxicity than free curcumin. The synthetic cholesterol-based cationic lipid also enhanced cellular uptake of curcumin into tested cells. Cationic liposome alone showed low cytotoxicity at high doses with ED50 values of 90-210 microM.
N
N
Apiratikul
T
T
Penglong
K
K
Suksen
S
S
Svasti
A
A
Chairoungdua
B
B
Yingyongnarongkula
D002784:Cholesterol / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology*; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000494:pharmacology
D008081:Liposomes; D002784:Cholesterol; D003474:Curcumin