Association of the HLA-B*52 allele with non-progression to AIDS in Brazilian HIV-1-infected individuals.
Several human leukocyte antigen (HLA) class I alleles are associated with the susceptibility to human immunodeficiency virus-1 (HIV-1) infection and/or AIDS progression. Of these, the HLA-B alleles are considered the strongest genetic determinant of disease outcome. We evaluated the influence of the HLA-B alleles on AIDS progression among HIV-1-positive individuals from Rio de Janeiro, Brazil, who were categorized as rapid progressors (RPs), typical progressors (TPs) or long-term non-progressors (LTNPs). In this study, significant differences in HLA-B allele frequencies were observed among the three progression groups for the B*48, B*49 and B*52 alleles. After controlling for other factors associated with AIDS progression, the presence of the B*52 allele was shown to be a significant protective factor (hazard ratio (HR) 0.49 (95% confidence interval (CI) 0.27-0.90) P<0.03). Although no direct association was observed between the presence of the B*27 or B*57 allele and the LTNP profile compared with the TP or RP groups, the adjusted model confirmed that these alleles are protective factors against AIDS progression (HR 0.62 (95% CI 0.38-0.99) P<0.05), as previously described. These data corroborate the existence of significant differences in HLA-B allele frequencies among the distinct AIDS progression profiles and further elucidate the role of HLA alleles in the outcome of HIV infections in diverse populations.
Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
S L M
SL
Teixeira
Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
N B R
NB
de Sá
Evandro Chagas Clinical Research Institute, FIOCRUZ, Rio de Janeiro, Brazil.
D P
DP
Campos
Evandro Chagas Clinical Research Institute, FIOCRUZ, Rio de Janeiro, Brazil.
A B
AB
Coelho
Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
M L
ML
Guimarães
Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
T C N F
TC
Leite
Evandro Chagas Clinical Research Institute, FIOCRUZ, Rio de Janeiro, Brazil.
V G
VG
Veloso
Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
M G
MG
Morgado
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000483:Alleles; D001938:Brazil; D005260:Female; D005787:Gene Frequency / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D059950:HLA-B52 Antigen / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged
D059950:HLA-B52 Antigen