Chinese herbal medicine for aspirin resistance: a systematic review of randomized controlled trials.
Aspirin resistance (AR) is a prevalent phenomenon and leads to significant clinical consequences, but the current evidence for effective interventional strategy is insufficient. The objective of this systematic review is thus to assess the efficacy and safety of Chinese herbal medicine (CHM) for AR. A systematical literature search was conducted in 6 databases until December 2012 to identify randomized controlled trials (RCTs) of CHM for AR. As a result, sixteen RCTs with a total of 1011 subjects were identified, suggesting that the interests of the medical profession and the public in the use of CHM for AR have grown considerably in the recent years. Tongxinluo capsule and Danshen-based prescriptions were the most frequently used herbal prescriptions, while danshen root, milkvetch root, Leech, and Rosewood were the most frequently used single herbs. Despite the apparent reported positive findings, it is premature to determine the efficacy and safety of CHM for the treatment of AR due to poor methodological quality and insufficient safety data. However, CHMs appeared to be well tolerated in all included studies. Thus, CHM as a promising candidate is worthy of improvement and development for further clinical AR trials. Large sample-size and well-designed rigorous RCTs are needed.
Department of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Ai-Ju
AJ
Liu
Department of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Hui-Qin
HQ
Li
Department of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Ji-Huang
JH
Li
Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Yuan-Yuan
YY
Wang
Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Dong
D
Chen
Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Yan
Y
Wang
Department of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Guo-Qing
0000-0001-5286-5696
GQ
Zheng