Differential effect of 3-dimensional color Doppler echocardiography for the quantification of mitral regurgitation according to the severity and characteristics.
BACKGROUND
The aim of this study is to explore the differential effect of 3-dimensional color Doppler echocardiography for the quantification of mitral regurgitation (MR). Two-dimensional color Doppler echocardiography-based MR quantification has well-documented limitations.


RESULTS
We consecutively enrolled 221 patients with MR. Adequate image quality was obtained by 2D- and 3D-color Doppler echocardiography in 211 (95.5%) patients. The quantitative differences between the MR volumes obtained by 2D- and 3D-proximal isovelocity surface area (PISA) were analyzed in various MR subgroups. In the validation cohort (n=52), MR volume obtained by 3D-PISA showed a better agreement with phase-contrast cardiac MRI than 2D-PISA (r=0.97 versus 0.84). In all 211 patients, 2D-PISA underestimated the MR volume when compared with 3D-PISA (52.4±19.6 versus 59.5±25.6 mL; P=0.005). A total of 33.3% with severe MR based on 3D-PISA were incorrectly assessed by 2D-PISA as having nonsevere MR. In the subgroup analysis, the MR severity (odds ratio, 6.96; 95% confidence interval, 3.04-15.94; P<0.001) and having an asymmetrical orifice (odds ratio, 11.48; 95% confidence interval, 3.72-35.4; P<0.001), and an eccentric jet (odds ratio, 3.82; 95% confidence interval, 1.27-11.48; P=0.017) were predictors of significant difference in MR volume (>15 mL) between 2D- and 3D-PISA methods.


CONCLUSIONS
Quantification of MR by 3D-PISA method is clinically feasible and more accurate than the current 2D-PISA method. MR quantification by 2D-PISA significantly underestimated MR volume with severe, eccentric MR with an asymmetrical orifice. This article demonstrates that 3D-color Doppler echocardiography could be used as a valuable tool to confirm treatment strategy in patients with significant MR.
From the Division of Cardiology, Severance Cardiovascular Hospital (J.C., R.H., G.-R.H., H.-J.C., S.H.S., I.J.C., C.-Y.S., N.C.) and Severance Biomedical Science Institute (H.-J.C.), Yonsei University Health System, Seoul, South Korea; and Department of Statistics, Graduate School of Health and Welfare, CHA University, Seongnam, South Korea (J.M.S.).
Jaehuk
J
Choi
From the Division of Cardiology, Severance Cardiovascular Hospital (J.C., R.H., G.-R.H., H.-J.C., S.H.S., I.J.C., C.-Y.S., N.C.) and Severance Biomedical Science Institute (H.-J.C.), Yonsei University Health System, Seoul, South Korea; and Department of Statistics, Graduate School of Health and Welfare, CHA University, Seongnam, South Korea (J.M.S.).
Ran
R
Heo
From the Division of Cardiology, Severance Cardiovascular Hospital (J.C., R.H., G.-R.H., H.-J.C., S.H.S., I.J.C., C.-Y.S., N.C.) and Severance Biomedical Science Institute (H.-J.C.), Yonsei University Health System, Seoul, South Korea; and Department of Statistics, Graduate School of Health and Welfare, CHA University, Seongnam, South Korea (J.M.S.).
Geu-Ru
GR
Hong
From the Division of Cardiology, Severance Cardiovascular Hospital (J.C., R.H., G.-R.H., H.-J.C., S.H.S., I.J.C., C.-Y.S., N.C.) and Severance Biomedical Science Institute (H.-J.C.), Yonsei University Health System, Seoul, South Korea; and Department of Statistics, Graduate School of Health and Welfare, CHA University, Seongnam, South Korea (J.M.S.). hjchang@yuhs.ac.
Hyuk-Jae
HJ
Chang
From the Division of Cardiology, Severance Cardiovascular Hospital (J.C., R.H., G.-R.H., H.-J.C., S.H.S., I.J.C., C.-Y.S., N.C.) and Severance Biomedical Science Institute (H.-J.C.), Yonsei University Health System, Seoul, South Korea; and Department of Statistics, Graduate School of Health and Welfare, CHA University, Seongnam, South Korea (J.M.S.).
Ji Min
JM
Sung
From the Division of Cardiology, Severance Cardiovascular Hospital (J.C., R.H., G.-R.H., H.-J.C., S.H.S., I.J.C., C.-Y.S., N.C.) and Severance Biomedical Science Institute (H.-J.C.), Yonsei University Health System, Seoul, South Korea; and Department of Statistics, Graduate School of Health and Welfare, CHA University, Seongnam, South Korea (J.M.S.).
Sang Hoon
SH
Shin
From the Division of Cardiology, Severance Cardiovascular Hospital (J.C., R.H., G.-R.H., H.-J.C., S.H.S., I.J.C., C.-Y.S., N.C.) and Severance Biomedical Science Institute (H.-J.C.), Yonsei University Health System, Seoul, South Korea; and Department of Statistics, Graduate School of Health and Welfare, CHA University, Seongnam, South Korea (J.M.S.).
In Jeong
IJ
Cho
From the Division of Cardiology, Severance Cardiovascular Hospital (J.C., R.H., G.-R.H., H.-J.C., S.H.S., I.J.C., C.-Y.S., N.C.) and Severance Biomedical Science Institute (H.-J.C.), Yonsei University Health System, Seoul, South Korea; and Department of Statistics, Graduate School of Health and Welfare, CHA University, Seongnam, South Korea (J.M.S.).
Chi-Young
CY
Shim
From the Division of Cardiology, Severance Cardiovascular Hospital (J.C., R.H., G.-R.H., H.-J.C., S.H.S., I.J.C., C.-Y.S., N.C.) and Severance Biomedical Science Institute (H.-J.C.), Yonsei University Health System, Seoul, South Korea; and Department of Statistics, Graduate School of Health and Welfare, CHA University, Seongnam, South Korea (J.M.S.).
Namsik
N
Chung
D001783:Blood Flow Velocity; D018618:Echocardiography, Doppler, Color / Q000379:methods*; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016017:Odds Ratio; D015203:Reproducibility of Results; D012720:Severity of Illness Index
echocardiography; mitral valve insufficiency