Dose adjustment of carboplatin in patients on peritoneal dialysis.
The Calvert equation has been extensively used to determine the dosage of carboplatin. However, in patients on dialysis, it predicts the same dosage regardless of the frequency of dialysis. Clearance of carboplatin during hemodialysis has been studied to a lesser extent, but there have been very few studies which have investigated the clearance of carboplatin in patients on peritoneal dialysis. A mathematical formula is proposed here to predict the dose of carboplatin for a given AUC in patients on peritoneal dialysis. This formula takes into account the frequency of dialysis sessions and the time delay between carboplatin infusion and the initiation of dialysis. The formula predicts an approximately similar dosage of carboplatin as that of the Calvert formula in patients undergoing peritoneal dialysis four times per day if dialysis is initiated 12 h after infusion. The formula may help in guiding the adjustment of carboplatin dose in patients who receive a lesser number of dialysis sessions per day and in those patients whose dialysis is initiated at different times (0-24 h) after carboplatin infusion. It is suggested that usage of this formula will result in a better dosage of carboplatin to suit specific dialysis frequencies in specific patients and eventually may result in a better efficacy and toxicity profile.
Department of Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard University, 50 Fruit Street, Boston, MA, 02114, USA, aguddati@partners.org.
Achuta K
AK
Guddati
Parijat S
PS
Joy
Creticus P
CP
Marak
D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016190:Carboplatin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000378:metabolism* / Q000628:therapy; D008962:Models, Theoretical; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D010530:Peritoneal Dialysis; D011379:Prognosis; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D016190:Carboplatin