Trithiocyanurate complexes of iron, manganese and nickel and their anticholinesterase activity.
The complexes of Fe(II), Mn(II) and Ni(II) with a combination of a Schiff base, nitrogen-donor ligand or macrocyclic ligand and trithiocyanuric acid (ttcH3) were prepared and characterized by elemental analysis and spectroscopies. Crystal and molecular structures of the iron complex of composition [Fe(L1)](ttcH2)(ClO4)·EtOH·H2O (1), where L1 is Schiff base derived from tris(2-aminoethyl)amine and 2-pyridinecarboxaldehyde, were solved. It was found that the Schiff base is coordinated to the central iron atom by six nitrogens forming deformed octahedral arrangement, whereas trithiocyanurate(1-) anion, perchlorate and solvent molecules are not coordinated. The X-ray structure of the Schiff base sodium salt is also presented and compared with the iron complex. The anticholinesterase activity of the complexes was also studied.
Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic. paulko@centrum.cz.
Pavel
P
Kopel
Centre of the Region Hana for Biotechnological and Agricultural Research, Faculty of Science, Palacky University & Institute of Experimental Botany, Academy of Sciences of Czech Republic, Slechtitelu 11, CZ-783 71 Olomouc, Czech Republic.
Karel
K
Dolezal
Environmental Inorganic Chemistry, Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Göteborg, Sweden.
Vratislav
V
Langer
Faculty of Military Health Sciences, University of Defence, Trebesska 1575, CZ-50001 Hradec Kralove, Czech Republic.
Daniel
D
Jun
Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic.
Vojtech
V
Adam
Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, CZ-50005 Hradec Kralove, Czech Republic.
Kamil
K
Kuca
Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic.
Rene
R
Kizek
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002802:Cholinesterases / Q000378:metabolism*; D045424:Complex Mixtures / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D057075:Enzyme Assays; D005029:Ethylenediamines / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D008024:Ligands; D008345:Manganese / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D051381:Rats; D012545:Schiff Bases / Q000737:chemistry; D014227:Triazines / Q000737:chemistry*
D002800:Cholinesterase Inhibitors; D045424:Complex Mixtures; D056831:Coordination Complexes; D005029:Ethylenediamines; D008024:Ligands; D011725:Pyridines; D012545:Schiff Bases; D014227:Triazines; C522921:picolinaldehyde; C099539:tris(2-aminoethyl)amine; D008345:Manganese; C039408:trithiocyanuric acid; D009532:Nickel; D007501:Iron; D002802:Cholinesterases