A web-based delphi study for eliciting helpful criteria in the positive diagnosis of hemophagocytic syndrome in adult patients.
The diagnosis of the reactive form of hemophagocytic syndrome in adults remains particularly difficult since none of the clinical or laboratory manifestations are specific. We undertook a study in order to elicit which features constitute helpful criteria for a positive diagnosis. In this Delphi study, the features investigated in the questionnaire and the experts invited to participate in the survey were issued from a bibliographic search. The questionnaire was iteratively proposed to experts via a web-based application with a feedback of the results observed at the preceding Delphi round. Experts were asked to label each investigated criterion in one of the following categories: absolutely required, important, of minor interest, or not assessable in the routine practice environment. A positive consensus was a priori defined as at least 75% answers observed in the categories absolutely required and important. The questionnaire investigated 26 criteria and 24 experts originating from 13 countries participated in the second and final Delphi round. A positive consensus was reached for the nine following criteria: unilineage cytopenia, bicytopenia, pancytopenia, presence of hemophagocytosis pictures on a bone marrow aspirate or on a tissue biopsy, high ferritin level, fever, organomegaly, presence of a predisposing underlying disease, and high level of lactate dehydrogenase. A negative consensus was reached for 13 criteria, and an absence of consensus was observed for 4 criteria. The study constitutes the first initiative to date for defining international guidelines devoted to the positive diagnosis of the reactive form of hemophagocytic syndrome.
INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France; AP-HP, Hôpital Saint-Antoine, Unité de Santé Publique, Paris, France.
Gilles
G
Hejblum
AP-HP, Hôpital de Bicêtre, Service de Médecine Interne, Le Kremlin Bicêtre, France; Université Paris-Sud 11, Faculté de Médecine Paris-Sud 11, Le Kremlin Bicêtre, France.
Olivier
O
Lambotte
AP-HP, Hôpital Saint-Louis, Service d'Immunologie Clinique, Paris, France.
Lionel
L
Galicier
AP-HP, Hôpital Saint-Antoine, Service d'Hématologie, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, Faculté de Médecine Pierre et Marie Curie, Paris, France.
Paul
P
Coppo
AP-HP, Hôpital Saint-Antoine, Service d'Hématologie Biologique, Paris, France.
Christophe
C
Marzac
Sorbonne Universités, UPMC Univ Paris 06, Groupe de Recherche Clinique n°7 MyPAC, Paris, France; AP-HP, Hôpital de Bicêtre, Service d'Hématologie Biologique, Le Kremlin Bicêtre, France.
Cédric
C
Aumont
Sorbonne Universités, UPMC Univ Paris 06, Faculté de Médecine Pierre et Marie Curie, Paris, France; AP-HP, Hôpital Saint-Antoine, Service de Médecine Interne, Paris, France.
Laurence
L
Fardet
D000328:Adult; D032921:Consensus; D003697:Delphi Technique; D006801:Humans; D020407:Internet; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis*; D011795:Surveys and Questionnaires