Background rhythm frequency and theta power of quantitative EEG analysis: predictive biomarkers for cognitive impairment post-cerebral infarcts.
In clinical settings, cerebral infarct is a common disease of older adults, which usually increases the risk of cognitive impairment. This study aims to assess the quantitative electroencephalography (qEEG) as a predictive biomarker for the development of cognitive impairment, post-cerebral infarcts, in subjects from the Department of Neurology. They underwent biennial EEG recording. Cerebral infarct subjects, with follow-up cognitive evaluation, were analyzed for qEEG measures of background rhythm frequency (BRF) and relative δ, θ, α, and β band power. The relationship between cognitive impairment and qEEG, and other possible predictors, was assessed by Cox regression. The results showed that the risk hazard of developing cognitive impairment was 14 times higher for those with low BRF than for those with high BRF (P < .001). Hazard ratio (HR) was also significant for more than median θ band power (HR = 5, P = .002) compared with less than median θ band power. The HRs for δ, α, and β bands were equal to the baseline demographic, and clinical characteristics were not significantly different. In conclusion, qEEG measures of BRF, and relative power in θ band, are potential predictive biomarkers for cognitive impairment in patients with cerebral infarcts. These biomarkers might be valuable in early prediction of cognitive impairment in patients with cerebral infarcts.
Tianjin First Center Hospital, Tianjin, China songyang6713@yeah.net.
Yang
Y
Song
Tianjin First Center Hospital, Tianjin, China.
Da-Wei
DW
Zang
Tianjin First Center Hospital, Tianjin, China.
Yan-Yu
YY
Jin
Tianjin First Center Hospital, Tianjin, China.
Zhi-Jun
ZJ
Wang
Tianjin First Center Hospital, Tianjin, China.
Hong-Yan
HY
Ni
Tianjin First Center Hospital, Tianjin, China.
Jian-Zhong
JZ
Yin
Tianjin First Center Hospital, Tianjin, China.
Dong-Xu
DX
Ji
D000368:Aged; D015415:Biomarkers; D015984:Causality; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D002681:China / Q000453:epidemiology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004569:Electroencephalography / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013826:Theta Rhythm
D015415:Biomarkers
background rhythm frequency; biomarker; cerebral infarcts; quantitative EEG; θ band power