Variations in mitochondrial tRNA(Thr) gene may not be associated with coronary heart disease.
Mutations in mitochondrial tRNAThr gene were recently reported to be associated with coronary heart disease. These mutations, such as T15889C, G15927A, G15930A and A15951G, were claimed to be pathogenic. To examine whether these mutations contributed to the genetic susceptibility to coronary heart disease, we analyzed the conservation index of these mutations between different species. In particular, reports concerning the role of the G15927A mutation was the most controversial. Therefore, based on the previous and this study, we conducted that mutations in mitochondrial tRNAThr gene may not be associated with coronary heart disease.
a Department of Emergency and.
Hui
H
Pei
b Department of Plastic Surgery , First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
Qian
Q
Peng
a Department of Emergency and.
Chao
C
Lan
a Department of Emergency and.
Bao Chi
BC
Liu
D001483:Base Sequence; D003324:Coronary Artery Disease / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D009690:Nucleic Acid Conformation; D010802:Phylogeny; D012363:RNA, Transfer, Thr / Q000235:genetics*; D016415:Sequence Alignment
D004272:DNA, Mitochondrial; D012363:RNA, Transfer, Thr
Coronary heart disease; mitochondrial tRNA; variants