Surfactant treatment for neonatal respiratory disorders other than respiratory distress syndrome.
BACKGROUND
It is suggested that there may be expanded use of surfactant replacement for the neonatal diseases such as meconium aspiration syndrome (MAS), pneumonia and possibly bronchopulmonary dysplasia (BPD).


OBJECTIVE
To evaluate the characteristics and short-term outcome of the neonates given exogenous surfactant because of the diseases other than respiratory disease syndrome (RDS).


METHODS
This retrospective study included 35 neonates admitted to the neonatal intensive care unit from January 2012 to December 2012 for an expanded use of surfactant. Data related to gestational age, birth weight, gender and perinatal risk factors were obtained from the patients' records. The short-term prognosis was also noted.


RESULTS
The diagnosis was sepsis in 16 patients, eight MAS, seven transient tachypnea of the newborns (TTN) and four BPD. Mean gestational age was 35.6 ± 4.5 weeks and mean birth weight was 2661 ± 981 g. Of overall cases, 65% were boys and 35% girls. The mortality rate was 17%. Of six fatal cases, three was with BPD, two with sepsis and one with MAS.


CONCLUSIONS
We think that surfactant replacement may be life saver in the neonatal diseases other than RDS such as BPD, MAS and sepsis by rapidly improving oxygenation. Further investigation is necessary to validate the significance of expanded use of surfactant.
Department of Neonatology, Tepecik Training and Research Hospital , Yenisehir, Izmir , Turkey.
Senem
S
Alkan
Esra Arun
EA
Ozer
Ozkan
O
Ilhan
Sumer
S
Sutcuoglu
Mansur
M
Tatli
D001997:Bronchopulmonary Dysplasia / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D007363:Intensive Care Units, Neonatal; D008297:Male; D008471:Meconium Aspiration Syndrome / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn; D012140:Respiratory Tract Diseases / Q000151:congenital / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D018805:Sepsis / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D059245:Transient Tachypnea of the Newborn / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology
D011663:Pulmonary Surfactants
Mortality; newborn; respiratory distress; surfactant