Inhibition of ceramide de novo synthesis with myriocin affects lipid metabolism in the liver of rats with streptozotocin-induced type 1 diabetes.
Nowadays diabetes is one of the most common metabolic diseases. Sphingolipids, which are vitally important constituents of intracellular signal transduction pathways, may be among the most pathogenic lipid moieties intermingled in the origin and development of diabetes. It is now well established that inhibition of de novo ceramide synthesis with myriocin exerts positive effects on lipid metabolism and glucose homeostasis in type 2 diabetes mellitus animal models. However, its influence on type I diabetes still remains unknown. Therefore, the scope of this paper is to fulfill that particular gap in our knowledge.
Department of Physiology, Medical University of Bialystok, Ulica Mickiewicza 2C, 15-222 Białystok, Poland.
Krzysztof
0000-0003-4927-4304
K
Kurek
Department of Physiology, Medical University of Bialystok, Ulica Mickiewicza 2C, 15-222 Białystok, Poland.
Patrycja
P
Wiesiołek-Kurek
Department of Public Health, Medical University of Bialystok, Poland.
Dominika M
DM
Piotrowska
Department of Physiology, Medical University of Bialystok, Ulica Mickiewicza 2C, 15-222 Białystok, Poland.
Bartłomiej
B
Łukaszuk
Department of Physiology, Medical University of Bialystok, Ulica Mickiewicza 2C, 15-222 Białystok, Poland.
Adrian
A
Chabowski
Department of Physiology, Medical University of Bialystok, Ulica Mickiewicza 2C, 15-222 Białystok, Poland.
Małgorzata
M
Żendzianendzian-Piotrowska
D000818:Animals; D002518:Ceramides / Q000096:biosynthesis*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000473:pathology; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D002518:Ceramides; D005229:Fatty Acids, Monounsaturated; D007166:Immunosuppressive Agents; C001996:thermozymocidin