LOX-1 expression and oxidized LDL uptake and toxicity in the HN33 neuronal cell line.
Cardiovascular risk factors appear to influence the risk and progression of neurodegenerative disease, but the mechanisms involved are poorly understood. We investigated the possible involvement of oxidized low-density lipoprotein receptor (LOX-1) and oxidized low-density lipoprotein (Ox-LDL) in neurodegeneration by studying the expression of LOX-1 and the effects of Ox-LDL in HN33 cells, a neuronal cell line of central nervous system origin. HN33 cells showed LOX-1 protein expression, hypoxic induction of LOX-1, Ox-LDL uptake and Ox-LDL toxicity. LOX-1/Ox-LDL signaling may contribute to the association between cardiovascular risk factors and neurodegenerative disease.
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
Xiaoou
X
Mao
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
Lin
L
Xie
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA. Electronic address: dgreenberg@buckinstitute.org.
David A
DA
Greenberg
D000818:Animals; D002460:Cell Line; D008077:Lipoproteins, LDL / Q000378:metabolism* / Q000633:toxicity; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D051127:Scavenger Receptors, Class E / Q000187:drug effects / Q000378:metabolism*
D008077:Lipoproteins, LDL; C495138:Olr1 protein, mouse; D051127:Scavenger Receptors, Class E; C099252:oxidized low density lipoprotein
HN33 cells; Hypoxia; LOX-1; Neurodegeneration; Ox-LDL