Lymphangitic retroperitoneal carcinomatosis occurring from metastatic sarcomatoid chromophobe renal cell carcinoma.
Forty -five year-old man with left renal mass underwent nephrectomy to reveal 20cm tumor diagnosed as sarcomatoid chromophobe renal cell carcinoma (CRCC). Lymph node metastasis of chromophobe and sarcomatoid components, disseminated tumor in retroperitoneal fat, lymphatic vessels, peri-renal adipose tissue in lymphangitic carcinomatosis pattern were identified. Chromophobe epithelial cells EMA, c-Kit, cytokeratin 7 positive; sarcomatoid cells were CD10, SMA positive with high proliferation index . Chromophobe epithelial cells had loss of heterozygosity (LOH) in chromosomes 1p, 1q while sarcomatoid cells had LOH in 3p,1p, 1q. In conclusion, sarcomatoid CRCC has aggressive biologic behavior and potential to metastasize in unusual patterns.
Translational Surgical Pathology, Lab. Of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Meghna
M
Alimchandani
Translational Surgical Pathology, Lab. Of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Karlena
K
Lara
Translational Surgical Pathology, Lab. Of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Maria
M
Tsokos
Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
W M
WM
Linehan
Translational Surgical Pathology, Lab. Of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Maria J
MJ
Merino
chromophobe; immunohistochemistry; loss of heterozygosity; lymph node metastasis; lymphangitic carcinomatosis; renal cell carcinoma; sarcomatoid