CLLonal selection: survival of the fittest?
In this issue of Blood, Rossi et al provide further evidence for clonal evolution in chronic lymphocytic leukemia (CLL) and demonstrate the clinical importance of small TP53-deleted subclones detected at diagnosis in determining the natural history of the disease.
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Claire
C
Dearden
D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000401:mortality*; D008297:Male; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53