Mesenchymal stem cells and transplant tolerance.
Different strategies are being tried to induce transplant tolerance in clinical settings; however, none of them are both safe and effective. Mesenchymal stem cells have been found to be potent immunomodulators and immunosuppressants. We discuss in this review different sources of mesenchymal stem cells and the potent role of adipose tissue-derived mesenchymal stem cells in induction of transplant tolerance including when to use them and how to use them for achieving the Utopian dream of transplant tolerance.
Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Centre (IKDRC) - Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, India.
Aruna V
AV
Vanikar
Hargovind L
HL
Trivedi
Ashutosh
A
Kumar
Saroj Chooramani
SC
Gopal
Vivek B
VB
Kute
D006085:Graft Survival; D006801:Humans; D056747:Immunomodulation; D007166:Immunosuppressive Agents / Q000276:immunology / Q000494:pharmacology; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000145:classification / Q000276:immunology; D023001:Transplantation Tolerance / Q000187:drug effects / Q000276:immunology
D007166:Immunosuppressive Agents
immune suppression; immunology; immunopathology; stem cell; transplantation