Desymmetrization of diolefinic diols by enantioselective amino-thiocarbamate-catalyzed bromoetherification: synthesis of chiral spirocycles.
A facile, efficient, and highly diastereo- and enantioselective bromoetherification of diolefinic diols has been developed using an amino-thiocarbamate catalyst. Further manipulations of the bromoether products enabled entry into a new class of spirocycles which are distinctively lacking in the literature.
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore) http://www.chemistry.nus.edu.sg/people/academic_staff/yeungyy.htm.
Daniel Weiliang
DW
Tay
Gulice Y C
GY
Leung
Ying-Yeung
YY
Yeung
Lewis base; asymmetric catalysis; chemoselectivity; cyclization; furans