The effect of recombinant human thyroid stimulating hormone on sustaining liver and renal function in thyroid cancer patients during radioactive iodine therapy.
OBJECTIVE
The aim of this study was to evaluate the effect of recombinant human thyroid stimulating hormone (rhTSH) on sustaining liver and renal function in thyroid cancer patients during radioiodine therapy (RIT).


METHODS
This study was conducted as a retrospective investigation between January 2005 and April 2012. Ninety-eight thyroid cancer patients who were treated with RIT using both thyroid hormone withdrawal (THW) and rhTSH were enrolled. The levels of cholesterol, aspartate aminotransaminase (AST), alanine transaminase (ALT), and serum creatinine (Cr) were analyzed before and after each RIT.


RESULTS
The cholesterol level before RIT with rhTSH was significantly lower than that after RIT with rhTSH (P<0.001). The cholesterol level increased before RIT with THW and decreased to within a normal range after RIT with THW (P<0.001). AST and ALT levels before RIT with THW were significantly higher than those before RIT with rhTSH (P<0.001). The serum Cr level before RIT with THW was higher than that before RIT with rhTSH (P<0.001). No significant differences in the serum values of AST, ALT, and Cr after RIT were observed between the THW and rhTSH groups. The remaining iodine was used to estimate radioiodine clearance and renal function indirectly. In 72 patients treated with the same activity of I for THW and rhTSH, the mean counts of regions of interest in the rhTSH group were significantly lower than those in the THW group (P<0.001).


CONCLUSIONS
rhTSH administration can sustain liver and renal function in thyroid cancer patients during RIT. Moreover, the use of rhTSH reduces unnecessary radiation exposure.
Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si, Korea.
Soo Jin
SJ
Lee
Ho-Young
HY
Lee
Won Woo
WW
Lee
Sang Eun
SE
Kim
D000293:Adolescent; D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D007677:Kidney Function Tests; D008099:Liver / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000494:pharmacology*; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000503:physiopathology* / Q000532:radiotherapy*; D013972:Thyrotropin / Q000494:pharmacology*; D055815:Young Adult
D007457:Iodine Radioisotopes; D011994:Recombinant Proteins; D013972:Thyrotropin; D002784:Cholesterol