Immunomodulation regulates mesenchymal stem cell-based bone regeneration.
Mesenchymal stem cell (MSC)-based regenerative medicine represents a promising frontier for bone reconstruction. Significant efforts have been devoted to clarifying the capacities of MSCs to repair or reconstruct bone tissue. This review provides a concise summary of current knowledge pertaining to the possible mechanisms of MSC action in the regeneration of bone, with particular focus on the interplay between donor MSCs and host immune response in the process of new bone regeneration.
Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory for Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.
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Su
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Shi
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Liu
D000818:Animals; D001861:Bone Regeneration / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation / Q000502:physiology*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology*
immune response; mesenchymal stem cell; regeneration