Acute Pancreatitis and Diabetic Ketoacidosis following L-Asparaginase/Prednisone Therapy in Acute Lymphoblastic Leukemia.
Acute pancreatitis and diabetic ketoacidosis are unusual adverse events following chemotherapy based on L-asparaginase and prednisone as support treatment for acute lymphoblastic leukemia. We present the case of a 16-year-old Hispanic male patient, in remission induction therapy for acute lymphoblastic leukemia on treatment with mitoxantrone, vincristine, prednisone, and L-asparaginase. He was hospitalized complaining of abdominal pain, nausea, and vomiting. Hyperglycemia, acidosis, ketonuria, low bicarbonate levels, hyperamylasemia, and hyperlipasemia were documented, and the diagnosis of diabetic ketoacidosis was made. Because of uncertainty of the additional diagnosis of acute pancreatitis as the cause of abdominal pain, a contrast-enhanced computed tomography was performed resulting in a Balthazar C pancreatitis classification.
Internal Medicine Department, "Dr. José Eleuterio González" University Hospital and School of Medicine, Universidad Autónoma de Nuevo León, Avenida Francisco I. Madero pte. y Avenida Gonzalitos s/n, Colonia Mitras Centro, 64460 Monterrey, NL, Mexico.
Dania Lizet
DL
Quintanilla-Flores
Internal Medicine Department, "Dr. José Eleuterio González" University Hospital and School of Medicine, Universidad Autónoma de Nuevo León, Avenida Francisco I. Madero pte. y Avenida Gonzalitos s/n, Colonia Mitras Centro, 64460 Monterrey, NL, Mexico.
Miguel Ángel
MÁ
Flores-Caballero
Internal Medicine Department, "Dr. José Eleuterio González" University Hospital and School of Medicine, Universidad Autónoma de Nuevo León, Avenida Francisco I. Madero pte. y Avenida Gonzalitos s/n, Colonia Mitras Centro, 64460 Monterrey, NL, Mexico.
René
R
Rodríguez-Gutiérrez
Research Division, School of Medicine, Universidad Autónoma de Nuevo León, Avenida Francisco I. Madero pte. y Avenida Gonzalitos s/n, Colonia Mitras Centro, 64460 Monterrey, NL, Mexico.
Héctor Eloy
HE
Tamez-Pérez
Research Division, School of Medicine, Universidad Autónoma de Nuevo León, Avenida Francisco I. Madero pte. y Avenida Gonzalitos s/n, Colonia Mitras Centro, 64460 Monterrey, NL, Mexico.
José Gerardo
JG
González-González