H2O2-promoted reactions of aliphatic primary amines with 1,3-diketones for the synthesis of 1H-pyrrol-3(2H)-ones at ambient temperature in water.
A green organic reaction of aliphatic primary amines with 1,3-diketones promoted by 30% aqueous H2O2 has been developed. It provides an inexpensive, regioselective, and efficient approach to 1H-pyrrol-3(2H)-ones with high yields from the simple and readily available starting materials in one pot via multicomponent tandem cyclization reactions and C-C cleavage under very mild and environmentally friendly reaction conditions.
Department of Chemistry, Anhui Agricultural University , Hefei, Anhui 230036, P. R. China.
Xi
X
Sun
Pinhua
P
Li
Xiuli
X
Zhang
Lei
L
Wang
D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006861:Hydrogen Peroxide / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature; D014867:Water
D000588:Amines; D007659:Ketones; D011758:Pyrroles; D014867:Water; D006861:Hydrogen Peroxide