The Arabidopsis KIN17 and its homolog KLP mediate different aspects of plant growth and development.
Proteins harboring the kin17 domain (KIN17) constitute a family of well-conserved eukaryotic nuclear proteins involved in nucleic acid metabolism. In mammals, KIN17 orthologs contribute to DNA replication, RNA splicing, and DNA integrity maintenance. Recently, we reported a functional characterization of an Arabidopsis thaliana KIN17 homolog (AtKIN17) that uncovered a role for this protein in tuning physiological responses during copper (Cu) deficiency and oxidative stress. However, functions similar to those described in mammals may also be expected in plants given the conservation of functional domains in KIN17 orthologs. Here, we provide additional data consistent with the participation of AtKIN17 in controlling general plant growth and development, as well as in response to UV radiation. Furthermore, the Arabidopsis genome codes for a second homolog to KIN17, we referred to as KIN17-like-protein (KLP). KLP loss-of-function lines exhibited a reduced inhibition of root growth in response to copper excess and relatively elongated hypocotyls in etiolated seedlings. Altogether, our experimental data point to a general function of the kin17 domain proteins in plant growth and development.
Department of Comparative Development and Genetics; Max Planck Institute for Plant Breeding Research; Cologne, Germany.
Antoni
A
Garcia-Molina
Department of Comparative Development and Genetics; Max Planck Institute for Plant Breeding Research; Cologne, Germany.
Shuping
S
Xing
Department of Comparative Development and Genetics; Max Planck Institute for Plant Breeding Research; Cologne, Germany.
Peter
P
Huijser
D017360:Arabidopsis / Q000254:growth & development / Q000378:metabolism* / Q000528:radiation effects; D029681:Arabidopsis Proteins / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D063245:Plant Development; D016601:RNA-Binding Proteins / Q000378:metabolism*; D014466:Ultraviolet Rays
D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins; C000592238:KIN17 protein, Arabidopsis; C000596949:KLP protein, Arabidopsis; D016601:RNA-Binding Proteins; D003300:Copper
Arabidopsis; Cu response; UV response; abiotic stress; kin17 domain-proteins; plant growth