[Pitfalls in determining resistance].
Selection of the optimal antimicrobial therapy is often crucial for the morbidity and mortality associated with an infection. A reliable antibiogram provides the basis for antibiotic therapy optimization. In case of life-threatening infections, minimal inhibitory concentration values should be available so that, in conjunction with knowledge of the pharmacokinetic properties of the respective antibiotics, a rational selection addressing the individual case is feasible. If only categorized results (susceptible, intermediate, resistant: S-I-R) are available, they should be established according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines in order to avoid therapeutic failures.
Institut für Medizinische Mikrobiologie und Infektionsepidemiologie, Liebigstr. 21, 04103, Leipzig, Deutschland, acr@medizin.uni-leipzig.de.
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Rodloff
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D001424:Bacterial Infections / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology*; D003428:Cross Infection / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology*; D004305:Dose-Response Relationship, Drug; D019983:Guideline Adherence; D006801:Humans; D007362:Intensive Care Units; D008826:Microbial Sensitivity Tests / Q000379:methods*; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology*
D000900:Anti-Bacterial Agents