Modular construction of dynamic nucleodendrimers.
Isoguanosine-containing dendritic small molecules self-assemble into decameric nucleodendrimers as observed by 1D NMR spectroscopy, 2D DOSY, and mass spectrometry. In particular, apolar building blocks readily form pentameric structures in acetonitrile while the presence of alkali metals promotes the formation of stable decameric assemblies with a preference for cesium ions. Remarkably, co-incubation of guanosine and isoguanosine-containing nucleodendrons results in the formation of decameric structures in absence of added salts. Further analysis of the mixture indicated that guanosine derivatives facilitate the formation, but are not involved in decameric structures; a process reminiscent of molecular crowding. This molecular system provides a powerful canvas for the rapid and modular assembly of polyfunctional dendritic macromolecules.
Centre de Recherche de Gif, Institut de Chimie des Substance Naturelles du CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette (France) http://rodchembiolab.com.
Valentina
V
Abet
Robert
R
Evans
Florian
F
Guibbal
Stefano
S
Caldarelli
Raphaël
R
Rodriguez
NMR spectroscopy; cesium; dendrimers; isoguanosine; self-assembly