Diagnosing thyroid lymphoma: steroid administration may result in rapid improvement of dyspnea : a report of two cases.
BACKGROUND
Thyroid nodules, whether benign or malignant, are slow growing masses. There are certain clinical situations where sudden rapid growth may occur and cause acute respiratory compromise secondary to tracheal compression.


METHODS
Here we describe two patients with suddenly enlarging thyroid nodules, who developed acute respiratory compromise in the absence of tracheal compression. Their symptoms rapidly improved with administration of corticosteroids, and in subsequent workup, both were diagnosed as thyroid lymphoma.


CONCLUSIONS
The potent effect of corticosteroids in the rapid improvement of respiratory compromise associated with thyroid lymphoma represents an important clinical finding. This opens the possibility for the favorable response to corticosteroid therapy to be regarded as a possible preliminary diagnostic tool for thyroid lymphoma in acute respiratory distress patients in the absence of tracheal compression. Subsequent retrospective studies are necessary to verify this hypothesis.
Department of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Oliver S
OS
Eng
Department of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Sebastian
S
Lesniak
Department of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Tomer
T
Davidov
Department of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Stanley Z
SZ
Trooskin
Diagnostic Tests; Dyspnea; Lymphoma; Steroids; Thyroid; Trachea