[Progression of research for the association between sex hormones and dry eye].
Researches of the correlation between sex hormones and dry eye have been concerned early.Ocular surface inflammation, epithelial apoptosis and abnormal expression of tear lipocalin and lipid may be important pathogenetic factors of various types of dry eye, and variedness of sex hormone level may have a certain correlation with these factors. The alteration of structure and function of tear film is the direct reason for dry eye. The change of sex hormone level likely gives influence to tear composition and pathological variation of related ocular surface tissues, then affects the structure and function of tear film, and finally lead to dry eye. Different sex hormones give certain different moderating effects to related ocular surface organization, so the recent correlational study of sex hormones and dry eye can be summarized in terms of androgen and estrogen, as these two sex hormones have certain impacts on tear composition and ocular surface organization respectively.
Department of Ophthalmology, EYE and ENT Hospital of Fudan University, Myopia Key Lab of Health Ministry, Shanghai 200032, China.
Tong
T
Lin
Department of Ophthalmology, EYE and ENT Hospital of Fudan University, Myopia Key Lab of Health Ministry, Shanghai 200032, China. Email: gong_lan70@aliyun.com.
Lan
L
Gong
D000728:Androgens / Q000737:chemistry; D015352:Dry Eye Syndromes; D004967:Estrogens / Q000737:chemistry; D012739:Gonadal Steroid Hormones / Q000737:chemistry*; D006801:Humans; D013666:Tears / Q000737:chemistry*
D000728:Androgens; D004967:Estrogens; D012739:Gonadal Steroid Hormones