[The predictive value of plasma cystatin C for non-ST-elevation acute coronary syndrome treated with percutaneous coronary intervention].
OBJECTIVE
To evaluate the prognosis value of plasma cystatin C in predicting adverse cardiac events after percutaneous coronary intervention (PCI) for non-ST-elevation acute coronary syndrome (NSTEACS).


METHODS
A total of 277 patients (212 male, mean age 59 ± 12 years) with NSTEACS underwent successful PCI. The patients were then divided into MACE group and non-MACE group. Patients were divided into 4 groups according to the level of cystatinC : Q1 (<0.78 mg/L), Q2 (0.78-0.93 mg/L), Q3 (0.94-1.11 mg/L), and Q4 ( ≥ 1.12 mg/L) . Risk factors for MACE were analyzed by Cox regression analysis.


RESULTS
The plasma Cys-C level were higher in MACE group than in non-MACE group(P < 0.05). The areas under ROC curve of Cys-C, cTnI, hsCRP an CK-MB to predict cardiac event were 0.737,0.630,0.692 and 0.650 respectively. After a follow-up of 1 year, the MACE in the Q2, Q3, and Q4 groups was higher than in the Q1 group (Logrank = 23.751, P < 0.01). Multivariate Cox regression analysis showed that cystatin C elevation was an independent predictor of major adverse cardiac events (P < 0.01).


CONCLUSIONS
High plasma cystatin C concentration is an independent predictor of major adverse cardiac events in patients with NSTEACS treated with PCI.
Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China.
Shan
S
Yan
Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China. Email:13861561408@163.com.
Xuefeng
X
Zhang
Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China.
Xiaoyi
X
Tian
Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China.
Jiangjin
J
Li
Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China.
Ling
L
Zhuang
Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China.
Xiwen
X
Zhang
Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China.
Yicheng
Y
Jiang
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D000368:Aged; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D016896:Treatment Outcome
D055316:Cystatin C