Catalytic asymmetric bromoetherification and desymmetrization of olefinic 1,3-diols with C2-symmetric sulfides.
An enantioselective and highly diastereoselective bromoetherification and desymmetrization of olefinic 1,3-diols has been developed using a C2-symmetric cyclic sulfide catalyst. This methodology has been successfully applied to the synthesis of the key intermediate of an orally active antifungal drug posaconazole (Noxafil).
Department of Chemistry, National University of Singapore , 3 Science Drive 3, Singapore 117543.
Zhihai
Z
Ke
Chong Kiat
CK
Tan
Feng
F
Chen
Ying-Yeung
YY
Yeung