Nontraditional applications in clinical pathology.
Most published reviews of preclinical toxicological clinical pathology focus on the fundamental aspects of hematology, clinical chemistry, coagulation, and urinalysis in routine toxicology animal species, for example, rats, mice, dogs, and nonhuman primates. The objective of this continuing education course was to present and discuss contemporary examples of nonroutine applications of clinical pathology endpoints used in the drug development setting. Area experts discussed bone turnover markers of laboratory animal species, clinical pathology of pregnant and growing laboratory animals, clinical pathology of nonroutine laboratory animal species, and unique applications of the Siemens Advia(®) hematology analyzer. This article is a summary based on a presentation given at the 31st Annual Symposium of the Society of Toxicologic Pathology, during the Continuing Education Course titled "Nontraditional Applications of Clinical Pathology in Drug Discovery and Preclinical Toxicology."
GlaxoSmithKline, Research Triangle Park, North Carolina, USA holly.l.jordan@gsk.com.
Holly L
HL
Jordan
Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Thomas C
TC
Register
Covance Laboratories, Inc., Madison, Wisconsin, USA.
Niraj K
NK
Tripathi
Charles River Laboratories, Preclinical Services Sherbrooke, Quebec, Canada.
Anne Provencher
AP
Bolliger
Amgen, Inc., Seattle, Washington, USA.
Nancy
N
Everds
LabThroughPut, Monsey, New York, USA.
David
D
Zelmanovic
Charles River Laboratories, Preclinical Services, Senneville, Quebec, Canada.
Florence
F
Poitout
Bristol-Myers Squibb Co, Princeton, New Jersey, USA.
Denise I
DI
Bounous
Bristol-Myers Squibb Co, Princeton, New Jersey, USA.
Debra
D
Wescott
Pfizer Inc, Cambridge, Massachusetts, USA.
Shashi K
SK
Ramaiah
D000818:Animals; D015415:Biomarkers / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism; D006224:Cricetinae; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D023381:Endpoint Determination; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D010338:Pathology, Clinical / Q000379:methods*; D011323:Primates; D011817:Rabbits; D051381:Rats
D015415:Biomarkers
Advia®; Wistar rat; bone biomarkers.; bone markers; clinical pathology; guinea pig; hamster; hematology; juvenile; minipig; pregnant; rabbit; transgenic