Diagnosis and counseling of fetal and neonatal HCMV infection.
Fetal HCMV infection is investigated by amniocentesis when a maternal primary infection is diagnosed or ultrasound (US/MRI) abnormalities are observed. In fetal blood, prognostic markers of symptomatic congenital infection may be evaluated for parental counseling. At birth, viral load measurement in body fluids may correlate with long-term sequelae, but the prognostic accuracy of symptomatic infection increases when maternal, fetal, and neonatal parameters are combined.
Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: m.zavattoni@smatteo.pv.it.
Maurizio
M
Zavattoni
Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Milena
M
Furione
Department of Obstetrics and Gynaecology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Alessia
A
Arossa
Department of Obstetrics and Gynaecology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Angela
A
Iasci
Department of Obstetrics and Gynaecology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Arsenio
A
Spinillo
Neonatology and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Giuseppina
G
Lombardi
Neonatology and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Mauro
M
Stronati
Radiology and Neuroradiology Department, Children's Hospital V. Buzzi, Milano, Italy.
Andrea
A
Righini
Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Fausto
F
Baldanti
D000649:Amniocentesis; D015415:Biomarkers / Q000097:blood / Q000652:urine; D003376:Counseling; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000175:diagnosis*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy
D015415:Biomarkers
Congenital infection; HCMV; Prognostic markers