Internal dosimetry through GATE simulations of preclinical radiotherapy using a melanin-targeting ligand.
The GATE Monte Carlo simulation platform based on the Geant4 toolkit is under constant improvement for dosimetric calculations. In this study, we explore its use for the dosimetry of the preclinical targeted radiotherapy of melanoma using a new specific melanin-targeting radiotracer labeled with iodine 131. Calculated absorbed fractions and S values for spheres and murine models (digital and CT-scan-based mouse phantoms) are compared between GATE and EGSnrc Monte Carlo codes considering monoenergetic electrons and the detailed energy spectrum of iodine 131. The behavior of Geant4 standard and low energy models is also tested. Following the different authors' guidelines concerning the parameterization of electron physics models, this study demonstrates an agreement of 1.2% and 1.5% with EGSnrc, respectively, for the calculation of S values for small spheres and mouse phantoms. S values calculated with GATE are then used to compute the dose distribution in organs of interest using the activity distribution in mouse phantoms. This study gives the dosimetric data required for the translation of the new treatment to the clinic.
Clermont Université, CNRS/IN2P3, Laboratoire de Physique Corpusculaire de Clermont-Ferrand (LPC), F-63177 Aubière, France.
Y
Y
Perrot
F
F
Degoul
P
P
Auzeloux
M
M
Bonnet
F
F
Cachin
J M
JM
Chezal
D
D
Donnarieix
P
P
Labarre
N
N
Moins
J
J
Papon
L
L
Rbah-Vidal
A
A
Vidal
E
E
Miot-Noirault
L
L
Maigne
D000818:Animals; D008024:Ligands; D008297:Male; D008543:Melanins / Q000378:metabolism*; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D051379:Mice; D058990:Molecular Targeted Therapy; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods*; D014057:Tomography, X-Ray Computed
D008024:Ligands; D008543:Melanins