Two new bufadienolides from the rhizomes of Helleborus thibetanus with inhibitory activities against prostate cancer cells.
Two new bufadienolide glycosides (1 and 2) with an A/B trans ring fusion together with nine known compounds (3-11) were isolated from the rhizomes of Helleborus thibetanus. The structures of new compounds were elucidated by extensive spectroscopic analyses in combination with single-crystal X-ray diffraction. The bufadienolides 1 and 3-6 exhibited potent cytotoxic activities against the prostate cancer cells.
a Key Laboratory of Traditional Chinese Medicine Resource and Compound Prescription, Ministry of Education , Hubei University of Traditional Chinese Medicine , Wuhan 430065 , P.R. China.
Wei
W
Cheng
Ya-Fang
YF
Tan
Hai-Yan
HY
Tian
Xiang-Wen
XW
Gong
Ke-Li
KL
Chen
Ren-Wang
RW
Jiang
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002018:Bufanolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D039322:Helleborus / Q000737:chemistry*; D006801:Humans; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D027343:Rhizome / Q000737:chemistry
C000592533:14beta-hydroxy-3beta-(beta-D-glucopyranosyloxy)-5alpha-bufa-20,22-dienolide; C000592534:3beta-(beta-D-glucopyranosyloxy)-5alpha,14beta-bufa-20,22-dienolide; D000972:Antineoplastic Agents, Phytogenic; D002018:Bufanolides; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D006027:Glycosides
Helleborus thibetanus; X-ray crystallographic analyses; bufadienolide glycosides; cytotoxic activity