RANKL expression in periodontal disease: where does RANKL come from?
Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. In this review, we have summarized the sources of RANKL in periodontal disease and explored which factors may regulate RANKL expression in this disease.
Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China.
Bin
0000-0001-8690-1835
B
Chen
Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China.
Wenlei
W
Wu
Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China.
Weibin
W
Sun
Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China.
Qian
0000-0003-0412-5014
Q
Zhang
Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China.
Fuhua
0000-0001-5632-9487
F
Yan
Bone Research Laboratory, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane, Qld 4059, Australia.
Yin
0000-0003-1785-3491
Y
Xiao
D016301:Alveolar Bone Loss / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D010010:Osteoclasts / Q000378:metabolism* / Q000473:pathology; D053245:RANK Ligand / Q000096:biosynthesis*
D053245:RANK Ligand; C505688:TNFSF11 protein, human