Association Between 6-Minute Walk Test and All-Cause Mortality, Coronary Heart Disease-Specific Mortality, and Incident Coronary Heart Disease.
OBJECTIVE
To examine the association between 6-min walk test (6 MWT) performance and all-cause mortality, coronary heart disease mortality, and incident coronary heart disease in older adults.


METHODS
We conducted a time-to-event analysis of 1,665 Cardiovascular Health Study participants without prevalent cardiovascular disease with a 6 MWT.


RESULTS
During a mean follow-up of 8 years, there were 305 incident coronary heart disease events, and 504 deaths of which 100 were coronary heart disease-related deaths. The 6 MWT performance in the shortest two distance quintiles was associated with increased risk of all-cause mortality (290-338 m: hazard ratio [HR] = 1.7; 95% confidence interval [CI] = [1.2, 2.5]; <290 m: HR = 2.1; 95% CI = [1.4, 3.0]). The adjusted risk of coronary heart disease mortality incident events among those with a 6 MWT < 290 m was not significant.


CONCLUSIONS
Performance on the 6 MWT is independently associated with all-cause mortality and is of prognostic utility in community-dwelling older adults.
Reading Health System, West Reading, PA, USA a.yazzzd@gmail.com.
Ali
A
Yazdanyar
Atlantic Health System, Morristown, NJ, USA.
Michael M
MM
Aziz
University of Arizona, Tuscon, USA.
Paul L
PL
Enright
Temple University, Philadelphia, PA, USA.
Daniel
D
Edmundowicz
University of Pittsburgh, PA, USA.
Robert
R
Boudreau
University of Pittsburgh, PA, USA.
Kim
K
Sutton-Tyrell
University of Pittsburgh, PA, USA.
Lewis
L
Kuller
University of Pittsburgh, PA, USA.
Anne B
AB
Newman
exercise; geriatrics; mortality; physical function