Interferon-stimulated genes: roles in viral pathogenesis.
Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo.
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States. Electronic address: john.schoggins@utsouthwestern.edu.
John W
JW
Schoggins
D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects*; D054884:Host-Pathogen Interactions / Q000187:drug effects / Q000235:genetics; D006801:Humans; D007372:Interferons / Q000378:metabolism / Q000494:pharmacology*; D014777:Virus Diseases / Q000235:genetics* / Q000378:metabolism / Q000821:virology*; D014780:Viruses / Q000472:pathogenicity*
D007372:Interferons