Recent developments on thiourea based anticancer chemotherapeutics.
The recent emergence of anticancer activity of thiourea derivatives have inspired the medicinal chemist to design and synthesize new thiourea derivatives. These thiourea based anticancer chemotherapeutics inhibit cancer propagation by acting as inhibitors of topoisomerase, protein tyrosine kinase, somatostatin agonists, sirtuins, and carbonic anhydrase (CA). This review summarizes the recent developments on the thiourea based anticancer chemotherapeutics.
Vikas
V
Kumar
Department of Chemistry, U.G.C. Center of Advance Studies in Chemistry, Guru Nanak Dev University, Amritsar-143005, India. sschimni@yahoo.com.
Swapandeep Singh
SS
Chimni
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002256:Carbonic Anhydrases / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D037761:Sirtuins / Q000378:metabolism; D013004:Somatostatin / Q000819:agonists; D013890:Thiourea / Q000494:pharmacology* / Q000627:therapeutic use*; D059003:Topoisomerase Inhibitors
D000970:Antineoplastic Agents; D059003:Topoisomerase Inhibitors; D013004:Somatostatin; D011505:Protein-Tyrosine Kinases; D037761:Sirtuins; D002256:Carbonic Anhydrases; D013890:Thiourea