Tumor heterogeneity confounds and illuminates: a case for Darwinian tumor evolution.
Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Kornelia
K
Polyak
D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics*; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D058750:Epithelial-Mesenchymal Transition; D047628:Estrogen Receptor alpha / Q000235:genetics*; D019143:Evolution, Molecular; D005260:Female; D018740:Genetic Heterogeneity; D006801:Humans; D012641:Selection, Genetic; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use; D013629:Tamoxifen / Q000627:therapeutic use
C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen