Evaluation of Mood Disorder Questionnaire (MDQ) in patients with mood disorders: a multicenter trial across China.
BACKGROUND
The aim of this study was to test the ability of the Chinese version of the Mood Disorder Questionnaire (MDQ) to identify Bipolar Disorders (BD) in patients diagnosed with Major Depressive Disorder (MDD) or Unipolar Disorder (UD) in the clinical setting.


METHODS
1,487 being treated for MDD or UD at 12 mental health centers across China, completed the MDQ and subsequently examined by the Mini International Neuropsychiatric Interview (MINI). Receiver Operating Characteristic(ROC) curves were used to determine the ability of the MDQ to differentiate between BD (BD, BD-I and BD-II) and MDD or UD and patients with BD-I from patients with BD-II.


RESULTS
Of the 1,487 patients, 309 (20.8%) satisfied the DSM-IV criteria for BD: 118 (7.9%) for BD-I and 191 (12.8%) for BD-II. When only part one of the MDQ was used, the best cutoff was 7 between BD and UD (sensitivity 0.66, specificity 0.88, positive predictive value 0.59, negative predictive value 0.91), 6 between BD-II and UD, and 10 between BD-I and BD-II. If all three parts of the MDQ were used, the MDQ could not distinguish between BD and UD at a cutoff of 7 (or 6), and the sensitivity was only 0.22 (or 0.24).


CONCLUSIONS
The Chinese version of the MDQ had good psychometric features in screening bipolar disorders from depressive patients with mood disorders when part two and part three of the MDQ were ignored.
Division of Mood Disorders, Shenzhen Mental Health Centre, Shenzhen Key Lab for Psychological Healthcare, Guangdong, China.
Hai-Chen
HC
Yang
Division of Mood Disorders, Shenzhen Mental Health Centre, Shenzhen Key Lab for Psychological Healthcare, Guangdong, China.
Tie-Bang
TB
Liu
Division of Mood Disorders, Shenzhen Mental Health Centre, Shenzhen Key Lab for Psychological Healthcare, Guangdong, China.
Han
H
Rong
Division of Mood Disorders, Shenzhen Mental Health Centre, Shenzhen Key Lab for Psychological Healthcare, Guangdong, China.
Jian-Qiang
JQ
Bi
Division of Mood Disorders, Shenzhen Mental Health Centre, Shenzhen Key Lab for Psychological Healthcare, Guangdong, China.
Er-Ni
EN
Ji
Mental Health Institute, The Second Xiangya Hospital, Central South University, Hunan, China.
Hong-Jun
HJ
Peng
Mental Health Institute, The Second Xiangya Hospital, Central South University, Hunan, China.
Xiao-Ping
XP
Wang
Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yi-Ru
YR
Fang
Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Cheng-Mei
CM
Yuan
Peking University Institute of Mental Health, Beijing, China.
Tian-Mei
TM
Si
Shanghai Tongji Hospital, Tongji University Medical School, Shanghai, China.
Zheng
Z
Lu
The First Hospital of Harbin Medical University, Heilongjiang, China.
Jian
J
Hu
Hangzhou Seventh People's Hospital, Zhejiang, China.
Zhi-Yu
ZY
Chen
West China Hospital, Sichuan University, Sichuan, China.
Yi
Y
Huang
The Affiliated Brain Hospital, Nanjing Medical University, Jiangsu, China.
Jing
J
Sun
The Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
Hui-Chun
HC
Li
Mood Disorders Center, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Chen
C
Hu
The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, China.
Jin-Bei
JB
Zhang
Mental Health Institute, The Second Xiangya Hospital, Central South University, Hunan, China.
Ling-Jiang
LJ
Li
D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D003865:Major Depressive Disorder / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics / Q000379:methods*; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires