Biocatalytic amide condensation and gelation controlled by light.
We report on a supramolecular self-assembly system that displays coupled light switching, biocatalytic condensation/hydrolysis and gelation. The equilibrium state of this system can be regulated by light, favouring in situ formation, by protease catalysed peptide synthesis, of self-assembling trans- in ambient light; however, irradiation with UV light gives rise to the cis-isomer, which readily hydrolyzes to its amino acid derivatives (cis- + ) with consequent gel dissolution.
WestCHEM, Department of Pure and Applied Chemistry, Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, UK. rein.ulijn@strath.ac.uk.
Jugal Kishore
JK
Sahoo
Siva Krishna Mohan
SK
Nalluri
Nadeem
N
Javid
Hannah
H
Webb
Rein V
RV
Ulijn
D000577:Amides / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry; D001407:Bacillus / Q000201:enzymology; D055162:Biocatalysis; D005782:Gels; D006868:Hydrolysis; D007536:Isomerism; D013820:Thermolysin / Q000378:metabolism; D014466:Ultraviolet Rays
D000577:Amides; D001391:Azo Compounds; D005782:Gels; D013820:Thermolysin; C009850:azobenzene