Mechanisms and dynamics of nuclear lamina-genome interactions.
The nuclear lamina (NL) interacts with the genomic DNA and is thought to influence chromosome organization and gene expression. Both DNA sequences and histone modifications are important for NL tethering of the genomic DNA. These interactions are dynamic in individual cells and can change during differentiation and development. Evidence is accumulating that the NL contributes to the repression of transcription. Advances in mapping, genome-editing and microscopy techniques are increasing our understanding of the molecular mechanisms involved in NL-genome interactions.
Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Mario
M
Amendola
Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address: b.v.steensel@nki.nl.
Bas
B
van Steensel
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002843:Chromatin / Q000378:metabolism; D002875:Chromosomes / Q000378:metabolism; D015870:Gene Expression; D016678:Genome; D006801:Humans; D034881:Nuclear Lamina / Q000235:genetics / Q000378:metabolism*
D002843:Chromatin