Nasal polyposis and immunoglobulin-G subclass deficiency.
OBJECTIVE
Study of the association between immunoglobulin-G (IgG) subclass deficiency and nasal polyposis.


METHODS
Longitudinal study (5 years) in a prospective cohort of 161 nasal polyposis patients. Analysis of the association between humoral immunodeficiency, rhinologic symptoms, endoscopy score and prescribed doses of local and systemic corticosteroids.


RESULTS
The prevalence of IgG subclass deficiency was 13.7% (22/161). One patient was diagnosed with common variable immunodeficiency (CVID). No significant differences were observed between the groups with and without pre-treatment deficiency for symptom severity, endoscopic score or local or systemic corticosteroid regimens at baseline or during the 5 years, following initiation of medical and surgical treatment. Only the Lund-Mackay CT score was significantly higher in the pre-treatment deficiency group.


CONCLUSIONS
There was no correlation between the presence of humoral deficiency and either symptom evolution after medical and surgical treatment or the dose of corticosteroids needed to control disease. Thus, a link between IgG subclass deficiency and nasal polyposis seems unlikely.
Département d'ORL et de chirurgie cervico-faciale, Hôpital Européen Georges-Pompidou, Faculté de Médecine Paris Descartes, Université Paris V, 20, rue Leblanc, 75015 Paris, France.
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Tran Khai Hoan
Service d'immunologie clinique, Hôpital Européen Georges-Pompidou, Faculté de Médecine Paris Descartes, Université Paris V, 20, rue Leblanc, 75015 Paris, France.
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Karmochkine
Département d'ORL et de chirurgie cervico-faciale, Hôpital Européen Georges-Pompidou, Faculté de Médecine Paris Descartes, Université Paris V, 20, rue Leblanc, 75015 Paris, France.
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Laccourreye
Département d'ORL et de chirurgie cervico-faciale, Hôpital Européen Georges-Pompidou, Faculté de Médecine Paris Descartes, Université Paris V, 20, rue Leblanc, 75015 Paris, France. Electronic address: pierre.bonfils@egp.aphp.fr.
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Bonfils
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001507:Beclomethasone / Q000627:therapeutic use; D017074:Common Variable Immunodeficiency / Q000175:diagnosis; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D017099:IgG Deficiency / Q000175:diagnosis*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015508:Nasal Obstruction / Q000209:etiology / Q000628:therapy; D009298:Nasal Polyps / Q000150:complications* / Q000628:therapy; D000857:Olfaction Disorders / Q000209:etiology / Q000628:therapy; D011446:Prospective Studies; D055815:Young Adult
D005938:Glucocorticoids; D001507:Beclomethasone
IgG; IgG subclasses; Immunodeficiency; Nasal polyposis; Sinus