Phylogenetic positions of RH blood group-related genes in cyclostomes.
The RH gene family in vertebrates consists of four major genes (RH, RHAG, RHBG, and RHCG). They are thought to have emerged in the common ancestor of vertebrates after two rounds of whole genome duplication (2R-WGD). To analyze the detailed phylogenetic relationships within the RH gene family, we determined three types of cDNA sequence that belong to the RH gene family in lamprey (Lethenteron reissneri) and designated them as RHBG-like, RHCG-like1, and RHCG-like2. Phylogenetic analyses clearly showed that RHCG-like1 and RHCG-like2 genes, which were probably duplicated in the lamprey lineage, are orthologs of gnathostome RHCG. In contrast, the clear phylogenetic position of the RHBG-like gene could not be obtained. Probably some convergent events for cyclostome RHBG-like genes prevented the accurate identification of their phylogenetic positions.
Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, 4-12-1 Nakanarusawa-cho Hitachi 316-8511, Japan.
Akinori
A
Suzuki
Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, 4-12-1 Nakanarusawa-cho Hitachi 316-8511, Japan.
Kouhei
K
Endo
Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, 4-12-1 Nakanarusawa-cho Hitachi 316-8511, Japan. Electronic address: tkitano@mx.ibaraki.ac.jp.
Takashi
T
Kitano
D000818:Animals; D049810:Genetic Speciation; D006196:Hagfishes / Q000235:genetics; D006801:Humans; D007798:Lampreys / Q000235:genetics*; D005810:Multigene Family; D010802:Phylogeny; D012204:Rh-Hr Blood-Group System / Q000145:classification* / Q000235:genetics*
D012204:Rh-Hr Blood-Group System
Duplication; Gene family; Lamprey; Phylogeny; RH