Potential anti-HPV and related cancer agents from marine resources: an overview.
Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of anti-HPV and related cancer activities. This paper will review the recent progress in research on the potential anti-HPV and related cancer agents from marine resources. In particular, it will provide an update on the anti-HPV actions of heparinoid polysaccharides and bioactive compounds present in marine organisms, as well as the therapeutic vaccines relating to marine organisms. In addition, the possible mechanisms of anti-HPV actions of marine bioactive compounds and their potential for therapeutic application will also be summarized in detail.
Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao 266003, China. shixinwang87@gmail.com.
Shi-Xin
SX
Wang
Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao 266003, China. xiaoshuangzhang89@126.com.
Xiao-Shuang
XS
Zhang
Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao 266003, China. hsguan@ouc.edu.cn.
Hua-Shi
HS
Guan
Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao 266003, China. wwwakin@ouc.edu.cn.
Wei
W
Wang
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000378:metabolism; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D030361:Papillomavirus Infections / Q000188:drug therapy; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014612:Vaccines / Q000008:administration & dosage / Q000302:isolation & purification
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001688:Biological Products; D011134:Polysaccharides; D014612:Vaccines