Pharmacokinetics of carbon nanoparticle-paclitaxel suspension for use in intraperitoneal chemotherapy.
OBJECTIVE
To study the pharmacokinetics of carbon nanoparticle-paclitaxel suspension (CNPS) in intraperitoneal chemotherapy.


METHODS
Thirty-three Wistar rats were randomly assigned to an experimental group (A) and a control group (B), to which intraperitoneal injections of CNPS and paclitaxel were administered, respectively. At time points ranging from 10 min to 7 days, we measured the concentration of paclitaxel in blood, mesenteric lymph nodes and peritoneal lavage.


RESULTS
The ratio of the area under the curve (AUC) in plasma of group A to that of group B was 0.6263. The ratio of AUC in lymph nodes of group A to group B was 0.7495 and that in peritoneal lavage was 1.25. The metabolic half-life of paclitaxel (t1/2) in plasma of group A was 1.607 times as long as that of group B. The t1/2 of paclitaxel in peritoneal lavage of group A was 0.879 as long as that of Group B. The t1/2 of paclitaxel in lymph nodes of group A was 1.097 as long as that of Group B.


CONCLUSIONS
Intraperitoneal chemotherapy by CNPS was characterized by low drug concentration in blood, high drug concentration in peritoneal and high security, but lack of significant lymph targeting and lymphatic retention effect.
Yuankun
Y
Cai
Xingyuan
X
Zhang
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity; D019540:Area Under Curve; D001201:Ascites / Q000378:metabolism; D002244:Carbon / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D005260:Female; D006207:Half-Life; D007274:Injections, Intraperitoneal; D008198:Lymph Nodes / Q000378:metabolism; D008657:Metabolic Clearance Rate; D053758:Nanoparticles; D017239:Paclitaxel / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity; D010533:Peritoneal Lavage; D051381:Rats; D013535:Suspensions; D014018:Tissue Distribution
D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D013535:Suspensions; D002244:Carbon; D017239:Paclitaxel