Structure-function studies of DNA polymerase λ.
DNA polymerase λ (pol λ) functions in DNA repair with its main roles considered to be filling short gaps during repair of double-strand breaks by nonhomologous end joining and during base excision repair. As indicated by structural and biochemical studies over the past 10 years, pol λ shares many common properties with other family X siblings (pol β, pol μ, and terminal deoxynucleotidyl transferase) but also has unique structural features that determine its specific functions. In this review, we consider how structural studies over the past decade furthered our understanding of the behavior and biological roles of pol λ.
Laboratory of Structural Biology and ‡Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, North Carolina 27709, United States.
Katarzyna
K
Bebenek
Lars C
LC
Pedersen
Thomas A
TA
Kunkel
D002384:Catalysis; D059766:DNA End-Joining Repair / Q000502:physiology; D019951:DNA Polymerase beta / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D004260:DNA Repair / Q000502:physiology*; D003854:Deoxyribonucleotides / Q000378:metabolism; D008958:Models, Molecular; D011487:Protein Conformation; D017434:Protein Structure, Tertiary / Q000502:physiology; D012265:Ribonucleotides / Q000378:metabolism
D003854:Deoxyribonucleotides; D012265:Ribonucleotides; C415367:DNA polymerase beta2; D019951:DNA Polymerase beta