Effect of Adiantum Capillus veneris Linn on an Animal Model of Testosterone-Induced Hair Loss.
Androgenetic alopecia is the most common form of hair loss in men. The present study was designed to evaluate the hair growth-promoting activity of a preparation of the Adiantum capillus-veneris Linn. (A. capillus-veneris) on albino mice using a testosterone-induced alopecia model. Five groups of albino mice were studied: (A) Testosterone solution only (n=6); (B) Testosterone + Finasteride solution (2%) (n=6); (C) Testosterone + vehicle (n=6); (D) Testosterone + A. capillus-veneris solution (1%) (n=6); (E) intact control (n=2, without testosterone). Alopecia was induced in all intervention groups by testosterone 1.0 mg subcutaneous. A. capillus-veneris solution was applied topically to the back skin of animals in the respective group. Hair growth was evaluated by visual observation and histological study of several skin sections via various parameters as follicle density (number of follicles/mm) and anagen/telogen ratio. After 21 days, a patch of diffuse hair loss was seen in animals received testosterone while animals treated with A. capillus-veneris showed less hair loss as compared to those treated with testosterone only. The follicular density observed in the A. capillus-veneris-treated group was 1.92 ± 0.47, compared to 1.05 ± 0.21 in testosterone-group and 2.05 ± 0.49 in finasteride-treated animals. Anagen/telogen ratio was significantly affected by A. capillus-veneris, which was 0.92 ± 0.06 as compared with 0.23 ± 0.03 and 1.12 ± 0.06 for testosterone and finasteride treated groups, respectively. According to visual observation and quantitative data (follicular density and anagen/telogen ratio), A. capillus-veneris was found to possess good activity against testosterone-induced alopecia.
Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran .
Maryam
M
Noubarani
School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran.
Hossein
H
Rostamkhani
School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran.
Mohammad
M
Erfan
School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran.
Mohammad
M
Kamalinejad
Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran .
Mohammad Reza
MR
Eskandari
School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran.
Mohammad
M
Babaeian
School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran.
Jamshid
J
Salamzadeh
Adiantum capillus-veneris linn; Anderogenetic alopecia; Hair growth; Testosterone