Obesity and cancer pathogenesis.
Overweight and obesity have reached pandemic levels on a worldwide basis and are associated with increased risk and worse prognosis for many but not all malignancies. Pathophysiologic processes that affect this association are reviewed, with a focus on the relationship between type 2 diabetes mellitus and cancer, lessons learned from the use of murine models to study the association, the impact of obesity on pancreatic cancer, the effects of dietary fats and cholesterol on cancer promotion, and the mechanisms by which the intestinal microbiome affects obesity and cancer.
Departments of Medicine, Biochemistry, and Genetics, Center for Science, Health and Society, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Nathan A
NA
Berger
D000818:Animals; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D004041:Dietary Fats; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009765:Obesity / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors
D004041:Dietary Fats
cancer and obesity; cholesterol; diabetes; dietary fats; intestinal microbiome; murine models; pancreatic cancer