Hallucinations and negative symptoms differentially revealed by frontal and temporal responses to speech in schizophrenia.
BACKGROUND
Auditory verbal hallucinations (AVH) in schizophrenia may arise because of aberrant speech perception. We used an electroencephalography method to examine the neural processes underlying speech perception in schizophrenic patients with hallucinations.


METHODS
Cortical event-related potentials (ERPs) were analyzed topographically (scalp potential and scalp current density (SCD) mapping) in response to the vowel /a/ using a passive paradigm in 26 patients with schizophrenia.


RESULTS
From the SCD distribution of the P1 peak, we showed that, whereas the hallucination score (PSYRATS) was negatively correlated with the amplitude of the frontal currents, the PANSS negative symptom score was negatively correlated with the amplitude of the temporal currents in patients with schizophrenia.


CONCLUSIONS
These results provide evidence that AVH and negative symptoms are associated with abnormal early processing of speech. Whereas AVH are related to decreased early frontal activation, negative symptoms are associated with a reduced early temporal response.
UMR 930 Imagerie et Cerveau, INSERM, Université François Rabelais de Tours, Tours, France; CHRU de Tours, Tours, France. Electronic address: jerome.graux@univ-tours.fr.
Jérôme
J
Graux
Brain Dynamics and Cognition Team, Lyon Neuroscience Research Center (CRNL), INSERM, CNRS, Lyon F-69500, France; University Lyon 1, Lyon F-69500, France. Electronic address: aurelie.bidet-caulet@inserm.fr.
Aurélie
A
Bidet-Caulet
UMR 930 Imagerie et Cerveau, INSERM, Université François Rabelais de Tours, Tours, France; CHRU de Tours, Tours, France. Electronic address: frederique.brilhault@univ-tours.fr.
Frédérique
F
Bonnet-Brilhault
UMR 930 Imagerie et Cerveau, INSERM, Université François Rabelais de Tours, Tours, France; CHRU de Tours, Tours, France. Electronic address: vincent.camus@univ-tours.fr.
Vincent
V
Camus
UMR 930 Imagerie et Cerveau, INSERM, Université François Rabelais de Tours, Tours, France; CHRU de Tours, Tours, France. Electronic address: nicole.bruneau@univ-tours.fr.
Nicole
N
Bruneau
D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006212:Hallucinations / Q000209:etiology*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology*; D013067:Speech Perception / Q000502:physiology*; D013702:Temporal Lobe / Q000503:physiopathology*; D055815:Young Adult
Hallucinations; Negative symptoms; P1; Scalp current density; Schizophrenia; Speech auditory ERPs