Do alpha-glucosidase inhibitors have the potential to induce portal venous gas? -Two clinical case reports.
We herein report two cases of portal venous gas (PVG) following alpha-glucosidase inhibitor (α-GI) therapy for diabetes mellitus. Anti-diabetic treatment with voglibose was commenced in the first case, while the second case was treated with miglitol. Both patients recovered without intensive treatment after discontinuing the α-GI therapy. α-GI medications may increase internal intestinal tract pressure by releasing carbon dioxide and hydrogen gas, potentially causing pneumatosis cystoides intestinalis (PCI) or PVG. Our experience suggests that α-GI therapy is an important potential cause of portal venous gas that can be treated conservatively.
Gastroenterological Center, Yokohama Shin-midori General Hospital, Japan.
Hiroaki
H
Makiyama
Ryoko
R
Kataoka
Masaru
M
Tauchi
Hiroki
H
Sumitomo
Rikiya
R
Fuita
D000368:Aged; D000369:Aged, 80 and over; D003920:Diabetes Mellitus / Q000188:drug therapy*; D003937:Diagnosis, Differential; D004618:Embolism, Air / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D065089:Glycoside Hydrolase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011006:Pneumatosis Cystoides Intestinalis / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D011169:Portal Vein / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
D065089:Glycoside Hydrolase Inhibitors