[Immune-mediated inflammatory diseases in patients with inflammatory bowel disease. Baseline data from the Aquiles study].
OBJECTIVE
To determine the prevalence of immune-mediated inflammatory diseases (IMID) in a cohort of patients with inflammatory bowel disease (IBD) enrolled in hospital gastroenterology outpatients units for the AQUILES study, a prospective 2-year follow-up study.


METHODS
We included patients ≥18 years old with a prior or new diagnosis of IBD (Crohn disease [CD], ulcerative colitis [UC] or indeterminate colitis). Diagnoses were collected in a cross-sectional manner from the clinical records at enrollment of a new patient in the study.


RESULTS
We included 526 patients (mean age 40.2 years; 47.3% men, 52.7% women), 300 with CD (57.0%), 218 with UC (41.4%) and 8 with indeterminate colitis. Other types of IMID were present in 71 patients (prevalence: 13.5%, 95% CI: 10.8-16.7): 47 were spondyloarthropathies (prevalence: 8.9%); 18 psoriasis (3.4%); 5 pyoderma gangrenosum (1.0%), and 11 uveitis (2.1%). The prevalence of IMID was higher in patients with CD than in those with UC (17.0% [95% CI: 13.2-21.7] vs 9.2% [95% CI: 6.0-13.8], p=0.011). In the multivariate analysis, the variables associated with the presence of IMID were diagnosis of CD (OR=1.8 [95% CI: 1.1-3.2]) and duration of IBD ≥4 years (OR=2.1 [95% CI: 1.1-4.1] in those with disease duration 4-8 years, and OR=2.1 [95% CI: 1.2-3.9] in those with ≥8 years vs. <4 years).


CONCLUSIONS
In the cohort of patients with IBD in the AQUILES study, 13.5% had another IMID, with a higher prevalence in patients with CD and>4 years since disease onset.
Servicio de Gastroenterología, Hospital Gregorio Marañón, Madrid, España. Electronic address: drnachomarin@hotmail.com.
Ignacio
I
Marín-Jiménez
Servicio de Gastroenterología, Hospital Reina Sofía, Córdoba, España.
Valle
V
García Sánchez
Servicio de Gastroenterología, Hospital Universitario de La Princesa/Instituto de Investigación Sanitaria Princesa (IISP), Madrid,/Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), España.
Javier P
JP
Gisbert
Servicio de Gastroenterología, Hospital Universitario Fundación Alcorcón, Madrid, España.
José
J
Lázaro Pérez Calle
Servicio de Gastroenterología, Consorcio Hospital General Universitario de Valencia, Valencia, España.
Marisol
M
Luján
Servicio de Gastroenterología, Hospital Santa Creu i Sant Pau, Barcelona, España.
Jordi
J
Gordillo Ábalos
Servicio de Gastroenterología, Hospital Príncipe de Asturias, Alcalá de Henares, Madrid, España.
Susana
S
Tabernero
Departamento Médico, Merck, Sharp & Dohme de España, España.
Berta
B
Juliá
Departamento Médico, Merck, Sharp & Dohme de España, España.
Cristina
C
Romero
Departamento Médico, Merck, Sharp & Dohme de España, España.
Luis
L
Cea-Calvo
Servicio de Reumatología, Hospital La Princesa, IISP/Instituto de Investigación Sanitaria Princesa (IISP), Madrid, España.
Rosario
R
García-Vicuña
Servicio de Dermatología, Hospital 12 de Octubre, Madrid, España.
Francisco
F
Vanaclocha
D000328:Adult; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000276:immunology; D003092:Colitis / Q000453:epidemiology; D003093:Colitis, Ulcerative / Q000453:epidemiology* / Q000276:immunology; D015897:Comorbidity; D003424:Crohn Disease / Q000453:epidemiology* / Q000276:immunology; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000453:epidemiology; D017511:Pyoderma Gangrenosum / Q000453:epidemiology; D025241:Spondylarthritis / Q000453:epidemiology; D014605:Uveitis / Q000453:epidemiology
Colitis ulcerosa; Crohn disease; Enfermedad de Crohn; Enfermedad inflamatoria intestinal; Enfermedad inflamatoria mediada inmunológicamente; Extraintestinal manifestation; Immune-mediate inflammatory disease; Inflammatory bowel disease; Manifestación extraintestinal; Ulcerative colitis