Aliphatic and eudesmalolide esters extracted from the roots of Inula racemosa Hook.
BACKGROUND
Phytochemical investigation of hydroalcoholic extract of the root of Inula racemosa Hook.


METHODS
Open silica gel column chromatographic techniques with different solvent systems was used for isolation of aliphatic and eudesmalolide esters from hydroalcoholic extract of the root of Inula racemosa. The structure elucidation of the compounds was done on the basis of spectral data analysis, chemical reactions and comparision with literature data.


RESULTS
Phytochemical investigation of the hydroalcoholic extract of the root of Inula racemosa Hook. f. led to the isolation of (5z, 13z)-n-decanyl-n-docos-5, 13-dienoate, a new fatty acid ester, two new sesquiterpenic ester identified as 15-[(13z, 18'z, 20'z)-n-tricos-13, 18, 20-trienyl]-eudesmal-4 (11), 6, 12 (13)-trien-8,14-olide-15-oate and 15- [(16'z), (21'z)-n- tetracos-16', 21'- dienyl]-eudesmal-4 (11) 6, 12 (13)-trien-8, 14-olide-15-oate, two new eudesmanolide ester i.e. 15-[(16z)-n-monadec-16'- enyl]-eudesmal-4 (11) 6, 12 (13)-trien-8,14-olide-15-oate and 15-[(16'z)-n-tetracos-16'- enyl]-endesmal-4 (11), 6, 12 (13)-trien-8,14-olide-15-oate along with the known compound n-Hexadecanyl n-docosanoate.


CONCLUSIONS
Five new phytoconstituents were identified along with one known compound as aliphatic and eudesmalolide esters from the hydroalcoholic extract of the root of Inula racemosa, as mentioned above.
Department of Pharmacognosy and Phytochemistry, Phytochemistry Research Laboratory, Jamia Hamdard, New Delhi, India.
Maria
M
Khan
Department of Pharmacognosy and Phytochemistry, Phytochemistry Research Laboratory, Jamia Hamdard, New Delhi, India.
S R
SR
Mir
Department of Pharmacognosy and Phytochemistry, Phytochemistry Research Laboratory, Jamia Hamdard, New Delhi, India.
Abuzar
A
Ali
Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi, India.
Mohammad
M
Yusuf
Department of Pharmacognosy and Phytochemistry, Phytochemistry Research Laboratory, Jamia Hamdard, New Delhi, India.
Mohammed
M
Ali
Aliphatic esters; Inula racemosa; eudesmalolide esters; phytoconstituents; root extract