Antifertility activity of Artemisia vulgaris leaves on female Wistar rats.
OBJECTIVE
To evaluate the antifertility activity of Artemisia vulgaris leaves on female Wistar rats.


METHODS
The plant extract was tested for its effect on implant formation at two dose levels, 300 and 600 mg·kg⁻¹, respectively. The effective methanolic plant extract was further studied for estrogenic potency on ovariectomised immature female Wistar rats.


RESULTS
The data presented in this study demonstrate the antifertility potential of Artemisia vulgaris methanolic leaf extract, which shows a strong and significant decrease in implant formation (100%), and a strong estrogenic effect resulting in a significant increase in uterine weight in immature ovariectomised rats. These observations suggest that the methanolic extract of Artemisia vulgaris leaves has strong anti-implantation activity and estrogenic activity.


CONCLUSIONS
The methanolic plant extract of A. vulgaris has antifertility activity.
Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India. Electronic address: afsarsk_14@yahoo.com.
Afsar
A
Shaik
Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
Rupesh S
RS
Kanhere
Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
Rajaram
R
Cuddapah
Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
Kumar S
KS
Nelson
Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
Prasanth Reddy
PR
Vara
Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
Saisaran
S
Sibyala
D000818:Animals; D019306:Artemisia; D003270:Contraceptive Agents / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D009929:Organ Size; D010052:Ovariectomy; D048789:Phytoestrogens / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D017208:Rats, Wistar; D014599:Uterus / Q000187:drug effects*
D003270:Contraceptive Agents; D048789:Phytoestrogens; D010936:Plant Extracts
Anti-implantation activity; Antifertility activity; Artemisia vulgaris; Estrogenic activity