[Effects of penehyclidine inhalation on postoperative pulmonary complications of elderly patients after long-duration surgery].
OBJECTIVE
To explore the effects of penehyclidine inhalation on the incidence of pulmonary complications in elderly patients after long-duration surgery.


METHODS
For this prospective, double-blind and randomized controlled trial, 90 elderly patients undergoing long-duration surgery ( ≥ 3 hours) under general anesthesia and transferred into intensive care unit (ICU) of Peking University First Hospital during February 14, 2012 to September 13, 2012 were enrolled. After extubation, they were randomized into 3 groups to receive an inhalation of penehyclidine hydrochloride, ipratropium bromide or normal saline for 3 consecutive days. The primary endpoint was the incidence of pulmonary complications within 6 days post-extubation.


RESULTS
The incidence of bronchospasm was 3.3%, 3.2% and 20.7% respectively. And the rate of aminophylline use was 0,0 and 10.3% respectively (P = 0.025 and P = 0.038); the airway tract spasm-free duration within 6 days after extubation was 5.8 (5.5-6.2), 5.8 (5.5-6.2) and 5.3 (4.8-5.9) days (P = 0.028); the overall incidence of pulmonary complications was 70.0%, 71.0% and 75.9% (P = 0.865).


CONCLUSIONS
For elderly patients after long-duration surgery, a prophylactic atomizing inhalation of penehyclidine decreases the incidence of bronchospasm and the rate of aminophylline use after extubation.However, the overall incidence of pulmonary complications has no change.
Department of Anesthesiology and Surgical Intensive Care, Peking University First Hospital, Beijing 100034, China.
Ting
T
Yan
Department of Anesthesiology and Surgical Intensive Care, Peking University First Hospital, Beijing 100034, China. Email: wangdongxin@hotmail.com.
Dongxin
D
Wang
D000280:Administration, Inhalation; D000368:Aged; D000369:Aged, 80 and over; D000758:Anesthesia; D001986:Bronchial Spasm / Q000517:prevention & control; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008171:Lung Diseases / Q000517:prevention & control*; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011812:Quinuclidines / Q000008:administration & dosage* / Q000009:adverse effects*
D011812:Quinuclidines; C486140:penehyclidine