Synthesis of 1H-indazoles from N-tosylhydrazones and nitroaromatic compounds.
A new method for the synthesis of 1H-indazoles from readily available N-tosylhydrazones and nitroaromatic compounds has been developed. This transformation occurs under transition-metal-free conditions and shows a wide substrate scope. The method has been successfully applied to the formal synthesis of a bioactive compound, WAY-169916.
Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China. wangjb@pku.edu.cn.
Zhenxing
Z
Liu
Long
L
Wang
Haocheng
H
Tan
Shiyi
S
Zhou
Tianren
T
Fu
Ying
Y
Xia
Yan
Y
Zhang
Jianbo
J
Wang
D001713:Biphenyl Compounds / Q000737:chemistry*; D002384:Catalysis; D006835:Hydrazones / Q000737:chemistry*; D007191:Indazoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D009578:Nitrobenzenes / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis*; D014105:Tosyl Compounds / Q000737:chemistry*
D001713:Biphenyl Compounds; D006835:Hydrazones; D007191:Indazoles; D009578:Nitrobenzenes; D011720:Pyrazoles; D014105:Tosyl Compounds; C499198:WAY-169916