Three clustered cases of candidemia caused by Candida quercitrusa and mycological characteristics of this novel species.
We investigated three nosocomial Candida quercitrusa candidemia cases occurring within 2 months in a Chinese hospital. Isolates were identifiable only by DNA sequencing of the rRNA genes. Genetic (via random amplified polymorphic DNA [RAPD]) and protein mass spectral (via matrix-assisted laser desorption ionization-time of flight mass spectrometry [MALDI-TOF MS]) analyses yielded identical profiles suggesting an outbreak. The fluconazole MICs of all the strains were 16 to 32 μg/ml.
Department of Clinical Laboratory, Peking Union Medical College Hospital, Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Meng
M
Xiao
Department of Clinical Laboratory, Peking Union Medical College Hospital, Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
He
H
Wang
Department of Clinical Laboratory, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Juan
J
Lu
Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR-Pathology West, University of Sydney, Westmead Hospital, Darcy Road, Westmead, New South Wales, Australia.
Sharon C-A
SC
Chen
Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR-Pathology West, University of Sydney, Westmead Hospital, Darcy Road, Westmead, New South Wales, Australia.
Fanrong
F
Kong
Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China drmaxiaojun@gmail.com xycpumch@139.com.
Xiao-Jun
XJ
Ma
Department of Clinical Laboratory, Peking Union Medical College Hospital, Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China drmaxiaojun@gmail.com xycpumch@139.com.
Ying-Chun
YC
Xu
D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology; D002175:Candida / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D058387:Candidemia / Q000175:diagnosis / Q000382:microbiology*; D002681:China; D003428:Cross Infection / Q000175:diagnosis / Q000382:microbiology*; D015725:Fluconazole / Q000494:pharmacology; D006761:Hospitals; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008969:Molecular Sequence Data; D012335:RNA, Ribosomal / Q000235:genetics; D019105:Random Amplified Polymorphic DNA Technique; D017422:Sequence Analysis, DNA; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D000935:Antifungal Agents; D012335:RNA, Ribosomal; D015725:Fluconazole