PRL-3 and E-cadherin show mutual interactions and participate in lymph node metastasis formation in gastric cancer.
E-cadherin, a transmembrane adhesion molecule, and phosphatase of regenerating liver 3 (PRL-3) protein, a member of the family of tyrosine phosphatases, seem to be responsible for cancer cell migration. Therefore, the study objective was to determine a correlation between PRL-3 and E-cadherin, to assess their expression in neoplastic tissue and normal mucosa of the stomach, to analyze their effect on cancer advancement, and to evaluate their potential as prognostic markers in gastric cancer. The expressions of PRL-3 and E-cadherin were assessed immunohistochemically in 71 patients with gastric cancer. Positive expression of PRL-3 was observed in 42.2 % of gastric cancer cases, whereas E-cadherin expression was abnormal in 38 % of cases. The study revealed that the positive PRL-3 expression and abnormal E-cadherin expression were associated with mucinous gastric carcinoma and lymph node involvement. The former was also related to the infiltrating type of tumor and abnormal E-cadherin expression. The expression of PRL-3, but not of E-cadherin, was associated with shorter survival of patients. PRL-3 and E-cadherin exhibit interactions in gastric cancer and are involved in the formation of lymph node metastases. The PRL-3 protein can be an independent predictive factor of overall survival in gastric cancer patients.
Department of General Pathomorphology, Medical University of Bialystok, ul. Waszyngtona 13, 15-269, Bialystok, Poland, pryczynicz.anna@gmail.com.
Anna
A
Pryczynicz
Katarzyna
K
Guzińska-Ustymowicz
Katarzyna
K
Niewiarowska
Dariusz
D
Cepowicz
Andrzej
A
Kemona
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D015820:Cadherins / Q000096:biosynthesis / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000378:metabolism*; D060066:Protein Interaction Maps / Q000235:genetics*; D017027:Protein Tyrosine Phosphatases / Q000096:biosynthesis / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
D014408:Biomarkers, Tumor; D015820:Cadherins; D015815:Cell Adhesion Molecules; D009363:Neoplasm Proteins; C484730:PTP4A3 protein, human; D017027:Protein Tyrosine Phosphatases