Higher body mass index in adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus is associated with lower risk HLA genes.
We hypothesised that higher body weight, a proposed risk factor for type 1 diabetes mellitus, would be associated with increased penetrance of lower risk genes. In adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus we found that higher body mass index was associated with the absence of the highest risk HLA genes.
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, VIC; Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Parkville 3050, VIC, Australia.
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S
Fourlanos
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, VIC; Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Parkville 3050, VIC, Australia.
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S
Elkassaby
Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, West Melbourne 3003, VIC, Australia.
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MD
Varney
Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Parkville 3050, VIC, Australia.
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PG
Colman
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, VIC. Electronic address: harrison@wehi.edu.
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LC
Harrison
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000235:genetics*; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D050177:Overweight; D012307:Risk Factors
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens
Body weight; Gene penetrance; HLA; LADA; Type 1 diabetes mellitus