Multi-institutional retrospective study for the evaluation of ocular function-preservation rates in maxillary sinus squamous cell carcinomas with orbital invasion.
BACKGROUND
The purpose of this retrospective analysis was to evaluate ocular function and survival rates among treatment modalities in patients with maxillary sinus cancer with orbital invasion.


METHODS
Eighty-seven patients were classified according to the main treatment modality. Ocular function preservation rates and survival rates were evaluated for each therapeutic modality.


RESULTS
The 5-year overall survival rate for the en bloc resection, conservative surgery, superselective intra-arterial chemotherapy, and radiotherapy (RADPLAT), intravenous chemoradiotherapy (IV-CRT) was 70%, 35%, 49%, and 31%, respectively. The ocular function preservation rate for each group was 15%, 27%, 30%, and 17%, respectively. In the en bloc resection group, there was no significant difference in the 5-year overall survival rate between patients with orbital exenteration and those without orbital exenteration (72% vs 71%; p = .9321).


CONCLUSIONS
The en bloc resection group showed a favorable survival rate but a low preservation rate. Preservation of orbital contents did not reduce the survival rate.
Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Tomohiro
T
Sakashita
Ryuichi
R
Hayashi
Akihiro
A
Homma
Kazuto
K
Matsuura
Kengo
K
Kato
Kazuyoshi
K
Kawabata
Nobuya
N
Monden
Yasuhisa
Y
Hasegawa
Tetsuro
T
Onitsuka
Yasushi
Y
Fujimoto
Shigemichi
S
Iwae
Kenji
K
Okami
Takashi
T
Matsuzuka
Kunitoshi
K
Yoshino
Masato
M
Fujii
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D059248:Chemoradiotherapy; D005123:Eye / Q000503:physiopathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial; D057194:Intention to Treat Analysis; D053208:Kaplan-Meier Estimate; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D008875:Middle Aged; D009915:Orbit / Q000473:pathology*; D017233:Orbit Evisceration; D009918:Orbital Neoplasms / Q000601:surgery; D020127:Recovery of Function; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck
D000970:Antineoplastic Agents
chemoradiotherapy; maxillary sinus cancer; ocular function; orbital invasion; squamous cell carcinoma