A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy.
Here, we describe a model in which telomeric repeat-binding factor 2 (TERF2) can control tumorigenesis not only via cancer cell-intrinsic mechanisms but also via non-cancer cell autonomous pathways. Indeed, we have recently shown that TERF2 regulates tissue homeostasis as it promotes the elimination of aged, damaged, and neoplastic cells by the immune system, opening the way to new therapeutic options against cancer.
Institut for Research on Cancer and Aging; Nice (IRCAN); CNRS UMR7284/INSERM U1081; Faculty of Medicine; Nice University; Nice, France.
Julien
J
Cherfils-Vicini
Regina Elena National Cancer Institute; Rome, Italy.
Pasquale
P
Zizza
Institut for Research on Cancer and Aging; Nice (IRCAN); CNRS UMR7284/INSERM U1081; Faculty of Medicine; Nice University; Nice, France ; Department of Medical Genetics; Archet 2 Hospital; CHU of Nice; Nice, France.
Eric
E
Gilson
Regina Elena National Cancer Institute; Rome, Italy.
Annamaria
A
Biroccio
NK cells; TERF2; immunosurveillance; telomeres; tumorigenesis