Gonadotrophin releasing hormone analogues for ovarian function preservation in young females undergoing chemotherapy.
Chemotherapy has significantly improved the prognosis of cancer patients with various malignancies. However, female patients, especially those whoich are premenopausal, suffer from significant chemotherapy induced ovarian function impairment, which decreases their quality of life. Many new techniques for ovarian preservation have been established in recent years. Although the use of gonadotrophin releasing hormone analogues (GnRHa) for this purpose is not a new concept, its effectiveness in protection of ovarian function is still debatable. This article deals with studies and metaanalyses which have been undertaken in the past, demonstrating the impact of GnRHa in ovarian function preservation, and whether their use can be implemented in routine practice.
Radiation Oncology, Medical Education and Research, Chandigarh, India E-mail : dranshubansal3@gmail.com.
Anshuma
A
Bansal
Firuza Darius
FD
Patel
Bhavana
B
Rai
Bhaswanth
B
Dhanireddy
Suresh Chand
SC
Sharma
D004358:Drug Therapy / Q000379:methods; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010053:Ovary / Q000187:drug effects*; D017697:Premenopause / Q000187:drug effects; D011788:Quality of Life
D007987:Gonadotropin-Releasing Hormone