High-dose vaginal maintenance metronidazole for recurrent bacterial vaginosis: a pilot study.
The purpose of this study was to explore the benefit of high-dose intravaginal metronidazole as a maintenance therapy in reducing recurrence rates of bacterial vaginosis (BV). Eighteen women with a history of recurrent BV and symptomatic BV were treated with metronidazole 750 mg suppository intravaginally daily for 7 days. Those in remission by Amsel criteria received metronidazole 750 mg twice weekly for 3 months with further follow-up for 3 months. High-dose metronidazole intravaginally was associated with rare clinical recurrence during the period of use. After cessation of suppression therapy, recurrence was high.
From the Departments of *Obstetrics and Gynecology, †Biochemistry and Molecular Biology, and ‡Infectious Diseases, Wayne State University School of Medicine, Detroit, MI.
Tina
T
Aguin
Robert A
RA
Akins
Jack D
JD
Sobel
D000282:Administration, Intravaginal; D000328:Adult; D001741:Black or African American; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D010865:Pilot Projects; D055502:Secondary Prevention; D016896:Treatment Outcome; D014481:United States; D014621:Vagina / Q000382:microbiology*; D014627:Vaginitis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D016585:Vaginosis, Bacterial / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016387:Women's Health
D000900:Anti-Bacterial Agents; D008795:Metronidazole