Renal biopsy: use of biomarkers as a tool for the diagnosis of focal segmental glomerulosclerosis.
Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since some biopsies lack a considerable quantifiable number of sclerotic glomeruli, given their focal aspect and the fact that FSGS occurs in less than half of the glomeruli. Therefore, many biological molecules have been evaluated as potential markers that would enhance the diagnosis of FSGS. Some of these molecules and receptors are associated with the pathogenesis of FSGS and have potential use in diagnosis.
Pathology Laboratory, Nephropathology Service, Federal University of Triângulo Mineiro, 38015-150 Uberaba, MG, Brazil.
Crislaine
C
Aparecida da Silva
Pathology Laboratory, Nephropathology Service, Federal University of Triângulo Mineiro, 38015-150 Uberaba, MG, Brazil.
Mariana
M
Molinar Mauad Cintra
Pathology Laboratory, Nephropathology Service, Federal University of Triângulo Mineiro, 38015-150 Uberaba, MG, Brazil.
Eliângela
E
de Castro Côbo
Immunology Laboratory, Department of Biological Sciences, Federal University of Triângulo Mineiro, 58051-900 Uberaba, MG, Brazil.
Marcos
M
Vinícius da Silva
Pathology Laboratory, Nephropathology Service, Federal University of Triângulo Mineiro, 38015-150 Uberaba, MG, Brazil.
Fabiano
F
Bichuette Custódio
Pathology Laboratory, Nephropathology Service, Federal University of Triângulo Mineiro, 38015-150 Uberaba, MG, Brazil.
Rosana
R
Rosa Miranda Corrêa
Human Immunology Research and Education Group, Technical Health School of UFPB, Federal University of Paraíba, 38025-180 João Pessoa, PB, Brazil.
Lúcio
L
Roberto Castellano
Pathology Laboratory, Nephropathology Service, Federal University of Triângulo Mineiro, 38015-150 Uberaba, MG, Brazil.
Marlene
M
Antônia dos Reis
Pathology Laboratory, Nephropathology Service, Federal University of Triângulo Mineiro, 38015-150 Uberaba, MG, Brazil.
Juliana
J
Reis Machado
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D005923:Glomerulosclerosis, Focal Segmental / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology*
D015415:Biomarkers