Macroautophagy and cell responses related to mitochondrial dysfunction, lipid metabolism and unconventional secretion of proteins.
Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion.
Laboratory of Biochemistry and Cell Biology (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (FUNDP), 61 rue de Bruxelles, Namur 5000, Belgium. stephane.demine@fundp.ac.be.
Stéphane
S
Demine
Laboratory of Biochemistry and Cell Biology (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (FUNDP), 61 rue de Bruxelles, Namur 5000, Belgium. sebastien.michel@fundp.ac.be.
Sébastien
S
Michel
Laboratory of Biochemistry and Cell Biology (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (FUNDP), 61 rue de Bruxelles, Namur 5000, Belgium. kayleen.vannuvel@fundp.ac.be.
Kayleen
K
Vannuvel
Laboratory of Biochemistry and Cell Biology (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (FUNDP), 61 rue de Bruxelles, Namur 5000, Belgium. s.wanet@fundp.ac.be.
Anaïs
A
Wanet
Laboratory of Biochemistry and Cell Biology (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (FUNDP), 61 rue de Bruxelles, Namur 5000, Belgium. patsy.renard@fundp.ac.be.
Patricia
P
Renard
Laboratory of Biochemistry and Cell Biology (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (FUNDP), 61 rue de Bruxelles, Namur 5000, Belgium. thierry.arnould@fundp.ac.be.
Thierry
T
Arnould