Use of threshold-specific energy model for the prediction of effects of smoking and radon exposure on the risk of lung cancer.
Lung cancer is the leading cause of cancer death in both men and women. Smoking causes 80-90% of cases of lung cancer. In this study, an attempt was made to assess the impact of cigarette smoking on the risk of lung cancer by the so-called threshold-specific energy model. This model allows to analyse the biological effects of radon daughter products on the lung tissue, and is based on the assumption that the biological effect (i.e. cell inactivation) will manifest itself after the threshold-specific energy z0 deposited in the sensitive volume of the cell is exceeded. Cigarette smoking causes, among others, an increase in the synthesis of the survivin protein that protects cells from apoptosis and thereby reduces their radiosensitivity. Based on these facts, an attempt was made to estimate the shape of the curves describing the increase in the oncological effect of radiation as a function of daily cigarette consumption.
Department of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Informatics, Comenius University, Mlynská dolina F-1, Bratislava 841 04, Slovak Republic radoslav.bohm@fmp.uniba.sk.
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Böhm
National Radiation Protection Institute, Praha 140 00, Czech Republic.
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Sedlák
Department of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Informatics, Comenius University, Mlynská dolina F-1, Bratislava 841 04, Slovak Republic.
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Bulko
Department of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Informatics, Comenius University, Mlynská dolina F-1, Bratislava 841 04, Slovak Republic.
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Holý
D000396:Air Pollutants, Radioactive / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D015233:Models, Statistical; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011886:Radon / Q000009:adverse effects*; D012907:Smoking / Q000009:adverse effects*
D000396:Air Pollutants, Radioactive; D011886:Radon