Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India.
OBJECTIVE
Genetic variants of the melanocortin-4 receptor gene (MC4R), agouti related protein (AGRP) and proopiomelanocortin (POMC) are reported to be associated with obesity. Therefore, the aim of this study is to examine MC4R rs17782313, MC4R rs17700633, AGRP rs3412352 and POMCrs1042571 for any association with obesity in North Indian subjects.


METHODS
The variants were investigated for association in 300 individuals with BMI ≥30 kg/m(2) and 300 healthy non-obese individuals BMI <30 kg/m(2.) The genotyping were analyzed by Taqman probes. The statistical analysis was performed by the SPSS software, ver.19 and p≤0.05 was considered statistically significant.


RESULTS
The genotypes of MC4R rs17782313 and POMC rs1042571 were significantly associated with obesity (C), (p=0.02; OR=1.7 and p=0.01; OR=1.6, respectively); however, MC4Rrs17700633 (p=0.001; OR=0.55) was associated with low risk. In addition, AGRPrs3412352 (p=0.93; OR=0.96) showed no association with obesity (BMI ≥30 kg/m(2)) in North Indian subjects.


CONCLUSIONS
This study provides the report about the significant association of MC4R (rs17782313) and POMC (rs1042571) with morbid obesity (BMI ≥30 kg/m(2)), but MC4R (rs17700633) and AGRP (rs34123523) did not show any association with obesity in the studied North Indian population.
Department of Physiology, King George's Medical University, (Erstwhile Chhatrapati Shahuji Maharaj Medical University), Chowk, Lucknow, Uttar Pradesh, India 226003.
Apurva
A
Srivastava
Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, Uttar Pradesh, India 226014.
Balraj
B
Mittal
Department of Pediatrics, King George's Medical University, (Erstwhile Chhatrapati Shahuji Maharaj Medical University), Chowk, Lucknow, Uttar Pradesh, India 226003.
Jai
J
Prakash
Department of Cardiology, King George's Medical University, (Erstwhile Chhatrapati Shahuji Maharaj Medical University), Chowk, Lucknow, Uttar Pradesh, India 226003.
Varun Shanker
VS
Narain
Department of Pathology, King George's Medical University, (Erstwhile Chhatrapati Shahuji Maharaj Medical University), Chowk, Lucknow, Uttar Pradesh, India 226003.
S M
SM
Natu
Department of Physiology, King George's Medical University, (Erstwhile Chhatrapati Shahuji Maharaj Medical University), Chowk, Lucknow, Uttar Pradesh, India 226003.
Neena
N
Srivastava
AGRP; Genetic variants; Genotype; MC4R; Obesity; POMC; Phenotype