Perisaccadic perception of visual space in people with schizophrenia.
Corollary discharge signals are found in the nervous systems of many animals, where they serve a large variety of functions related to the integration of sensory and motor signals. In humans, an important corollary discharge signal is generated by oculomotor structures and communicated to sensory systems in concert with the execution of each saccade. This signal is thought to serve a number of purposes related to the maintenance of accurate visual perception. The properties of the oculomotor corollary discharge can be probed by asking subjects to localize stimuli that are flashed briefly around the time of a saccade. The results of such experiments typically reveal large errors in localization. Here, we have exploited these well-known psychophysical effects to assess the potential dysfunction of corollary discharge signals in people with schizophrenia. In a standard perisaccadic localization task, we found that, compared with controls, patients with schizophrenia exhibited larger errors in localizing visual stimuli. The pattern of errors could be modeled as an overdamped corollary discharge signal that encodes instantaneous eye position. The dynamics of this signal predicted symptom severity among patients, suggesting a possible mechanistic basis for widely observed behavioral manifestations of schizophrenia.
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada, and Department of Psychology, McGill University, Montreal, Quebec H3A 1B1, Canada.
Alby
A
Richard
Jan
J
Churan
Veronica
V
Whitford
Gillian A
GA
O'Driscoll
Debra
D
Titone
Christopher C
CC
Pack
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D010468:Perceptual Disorders / Q000209:etiology*; D010775:Photic Stimulation; D011569:Psychiatric Status Rating Scales; D011601:Psychophysics; D011930:Reaction Time; D012438:Saccades / Q000502:physiology*; D012559:Schizophrenia / Q000150:complications*; D013028:Space Perception / Q000502:physiology*
corollary discharge; oculomotor; perception; saccades; schizophrenia; vision