Different expression of miRNAs in early esophageal squamous cell carcinoma with differential prognosis.
Patients at the same pathological stage of early esophageal squamous cell carcinoma (ESCC) have significantly different prognoses. The aim of this study was to explore the relationship between specific microRNAs (miRNAs) in two groups of early ESCC patients who had different prognoses at the pT1N0 stage, and to study the prognostic significance of different miRNAs in early ESCC metastasis. We tried to identify prognostic markers that may be helpful in the selection of appropriate treatment for patients with early ESCC. We used TaqMan Human miRNA Arrays to detect and analyze bioinformatically the expression profiles of miRNAs in two groups, and the reverse transcription polymerase chain reaction method to verify the differences in miRNA expression. The miRNA arrays revealed a total of 29 markedly downregulated miRNAs in the survival group compared with the deceased group. Such miRNAs were associated with lympho-vascular invasion and metastasis, and acted as predictive markers of lympho-vascular invasion and metastasis. The detection of these miRNAs forms an important basis for the treatment of early ESCC. It can also help determine those patients with early ESCC who are good candidates for endoscopic resection treatment and those who need additional treatment after endoscopic resection.
Department of Pathology, Beijing Chaoyang Hospital, Capital University, Beijing, China.
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J
Lu
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Lu
L
L
Xue
M
M
Jin
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology*; D015536:Down-Regulation; D055088:Early Detection of Cancer; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D020869:Gene Expression Profiling; D063990:Gene Ontology; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging
D035683:MicroRNAs
early esophageal squamous cell carcinoma; endoscopic resection; metastasis; microRNA; progression