Biological treatments given in patients with rheumatoid arthritis or ankylosing spondylitis modify HAT/HDAC (histone acetyltransferase/histone deacetylase) balance.
Clinical Investigation, Center Biotherapy, INSERM CIC-1431, INSERM CIC-1431, FHU INCREASE, University Hospital of Besançon, bâtiment St Joseph, 2, place Saint-Jacques, 25000 Besançon, France; Department of Rheumatology, University Hospital of Besançon, 25000 Besançon, France; Department of Therapeutics, University of Franche-Comté, 25000 Besançon, France; UPRES EA 4266, Pathogens and Inflammation Laboratory, SFR FED 4234, University of Franche-Comté, 25000 Besançon, France. Electronic address: etoussirot@chu-besancon.fr.
Eric
E
Toussirot
Department of Rheumatology, University Hospital of Besançon, 25000 Besançon, France; UPRES EA 4266, Pathogens and Inflammation Laboratory, SFR FED 4234, University of Franche-Comté, 25000 Besançon, France.
Daniel
D
Wendling
UPRES EA 4266, Pathogens and Inflammation Laboratory, SFR FED 4234, University of Franche-Comté, 25000 Besançon, France; Department of Virology, University Hospital of Besançon, 25000 Besançon, France.
Georges
G
Herbein
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000378:metabolism / Q000628:therapy*; D001691:Biological Therapy; D051548:Histone Acetyltransferases / Q000378:metabolism*; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000378:metabolism / Q000628:therapy*
D051548:Histone Acetyltransferases; D006655:Histone Deacetylases
Biologics; Epigenetics; Histone acetylation