Decreased serum nesfatin-1 levels in endometriosis.
OBJECTIVE
To investigate serum nesfatin-1 levels in endometriosis patients.


METHODS
Twenty-five women who were laparoscopically and histopathologically diagnosed with endometriosis (endometriosis group) and 25 women without any pelvic pathology detected by laparoscopy (control group) were enrolled in the study. Serum nesfatin-1 levels were compared between the two groups before and after adjustment for body mass index (BMI) and age.


RESULTS
Patients in the endometriosis group had lower BMI than those in the control group (22.3 ± 4.8 kg/m(2) vs. 25.8 ± 4.2 kg/m(2), p=0.009). There was no statistically significant correlation between BMI and serum nesfatin-1 levels (p=0.870). Serum nesfatin-1 level was statistically significantly lower in the endometriosis group than in the control group (7.2 ± 1.3 pg/ml vs. 10.6 ± 2.8 pg/ml, p=0.0001). This result did not change after the adjustment for BMI and age.


CONCLUSIONS
Serum levels of nesfatin-1 are decreased in endometriosis patients but its exact role in the etiopathogenesis of endometriosis remains to be clarified.
Etlik Zübeyde Hanım Women's Health Teaching and Research Hospital, Ankara, Turkey. Electronic address: ozlem.sengul@yahoo.com.
Özlem
Ö
Şengül
Etlik Zübeyde Hanım Women's Health Teaching and Research Hospital, Ankara, Turkey.
Berna
B
Dilbaz
Atatürk University Faculty of Medicine, Department of Pharmacology, Erzurum, Turkey.
Zekai
Z
Halıcı
Atatürk University Faculty of Medicine, Department of Pharmacology, Erzurum, Turkey.
Irmak
I
Ferah
Atatürk University Faculty of Pharmacy, Erzurum, Turkey.
Elif
E
Çadırcı
Etlik Zübeyde Hanım Women's Health Teaching and Research Hospital, Ankara, Turkey.
Fatma
F
Yılmaz
D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002135:Calcium-Binding Proteins / Q000097:blood*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000097:blood*; D004715:Endometriosis / Q000097:blood*; D005260:Female; D006801:Humans; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D010532:Peritoneal Diseases / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins
Endometriosis; Laparoscopy; Nesfatin-1