Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility.
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), represents a group of chronic inflammatory disorders caused by dysregulated immune responses in genetically predisposed individuals. Genetic markers are associated with disease phenotype and long-term evolution, but their value in everyday clinical practice is limited at the moment. IBD has a clear immunological background and interleukins play key role in the process. Almost 130 original papers were revised including meta-analysis. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but text often do not available for the doctors use these in the clinical practice nowadays. We conducted a systematic review of the current literature on interleukin and interleukin receptor gene polymorphisms associated with IBD, performing an electronic search of PubMed Database from publications of the last 10 years, and used the following medical subject heading terms and/or text words: IBD, CD, UC, interleukins and polymorphisms.
Lili Magyari, Erzsebet Kovesdi, Katalin Sumegi, Bela Melegh, Department of Medical Genetics, University of Pecs, 7624 Pecs, Hungary.
Lili
L
Magyari
Lili Magyari, Erzsebet Kovesdi, Katalin Sumegi, Bela Melegh, Department of Medical Genetics, University of Pecs, 7624 Pecs, Hungary.
Erzsebet
E
Kovesdi
Lili Magyari, Erzsebet Kovesdi, Katalin Sumegi, Bela Melegh, Department of Medical Genetics, University of Pecs, 7624 Pecs, Hungary.
Patricia
P
Sarlos
Lili Magyari, Erzsebet Kovesdi, Katalin Sumegi, Bela Melegh, Department of Medical Genetics, University of Pecs, 7624 Pecs, Hungary.
Andras
A
Javorhazy
Lili Magyari, Erzsebet Kovesdi, Katalin Sumegi, Bela Melegh, Department of Medical Genetics, University of Pecs, 7624 Pecs, Hungary.
Katalin
K
Sumegi
Lili Magyari, Erzsebet Kovesdi, Katalin Sumegi, Bela Melegh, Department of Medical Genetics, University of Pecs, 7624 Pecs, Hungary.
Bela
B
Melegh
D003093:Colitis, Ulcerative / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics; D005786:Gene Expression Regulation; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007107:Immune System; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D007378:Interleukins / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D018123:Receptors, Interleukin / Q000235:genetics*
D005819:Genetic Markers; D007378:Interleukins; D018123:Receptors, Interleukin
Crohn’s disease; Inflammatory bowel disease; Interleukin; Interleukin receptor; Polymorphisms; Ulcerative colitis