'Auto-click' functionalization for diversified copper(I) and gold(I) NHCs.
Azide-tagged Cu(I)-NHC reacts in an 'auto-click' process to furnish complexes functionalized by 1,2,3-triazoles bearing diverse substituents. The resulting Cu(I) complexes are amenable to further transmetallation to Au(I). The whole strategy proceeds with mild conditions and constitutes an efficient entry to functionalised metal-NHCs with biorelevant moieties.
Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, F-63000 Clermont-Ferrand, France. federico.cisnetti@univ-bpclermont.fr.
Houssein
H
Ibrahim
Clémentine
C
Gibard
Cédric
C
Hesling
Régis
R
Guillot
Laurent
L
Morel
Arnaud
A
Gautier
Federico
F
Cisnetti
D045744:Cell Line, Tumor; D057930:Click Chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006046:Gold / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006801:Humans; D018613:Microscopy, Confocal; D008968:Molecular Conformation; D014230:Triazoles / Q000737:chemistry
D056831:Coordination Complexes; D006571:Heterocyclic Compounds; D014230:Triazoles; D006046:Gold; D003300:Copper