Placotylene A, an inhibitor of the receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation, from a Korean sponge Placospongia sp.
A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively.
Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea. reihyoung@snu.ac.kr.
Hiyoung
H
Kim
Department of Pharmacy, Sunchon National University, 315 Maegok-dong, Suncheon, Jeollanam-do 540-742, Korea. mastiffk@naver.com.
Kwang-Jin
KJ
Kim
Research Institute of Basic Science, Sunchon National University, Suncheon 540-742, Korea. sa-dou@hanmail.net.
Jeong-Tae
JT
Yeon
Laboratory of Translational Therapeutics, Pharmacology Research Center, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea. hwan@krict.re.kr.
Seong Hwan
SH
Kim
Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea. dongfal2@snu.ac.kr.
Dong Hwan
DH
Won
College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 712-749, Korea. h5choi@yu.ac.kr.
Hyukjae
H
Choi
Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 120-750, Korea. sjnam@ewha.ac.kr.
Sang-Jip
SJ
Nam
Department of Pharmacy, Sunchon National University, 315 Maegok-dong, Suncheon, Jeollanam-do 540-742, Korea. sony@sunchon.ac.kr.
Young-Jin
YJ
Son
Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea. hjkang@snu.ac.kr.
Heonjoong
H
Kang
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D053280:Diynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008813:Mice, Inbred ICR; D010010:Osteoclasts / Q000187:drug effects* / Q000378:metabolism; D011161:Porifera / Q000737:chemistry*; D053245:RANK Ligand / Q000378:metabolism; D056910:Republic of Korea; D013237:Stereoisomerism
C000593350:14-iodotetradeca-13-en-3,5-diyn-1-ol; D053280:Diynes; D005233:Fatty Alcohols; D053245:RANK Ligand