[Adherence to patients antidepressant treatment and the factors associated of non-compiance].
OBJECTIVE
To know the adherence to treatment in patients who initiate antidepressant drugs and to analyze the determinant factors of non-compliance, so much clinical as sociodemographic.


METHODS
Prospective longitudinal observational study.


METHODS
Primary Health Care and Mental Health Surgeries of three Castilla-La Mancha Areas.


METHODS
185 adults patients who were started in antidepressant treatment were evaluated.


METHODS
Treatment adherence (test Haynes-Sackett, test Morisky-Green, count of tablets and MEMS), adverse effects, intensity of depressive symptoms, sociodemographic characteristics and other characteristics related to antidepressants or participants.


RESULTS
After 6months of beginning antidepressing treatment, 46.9% (95%IC: 36.5-57.3) showed an inadequate fulfilment by pill count method and 28.6% (95%IC: 19.1-38.0) with Morisky-Green's questionnaire. To 15 days the lack of adherence was 48.5% (95%IC: 40.6-56.4) and of 33.5% (95%IC: 26.1-41.0). The 38.4% (95%IC: 31.1-45.7) demonstrated some side effect during the follow-up. Using proportional risk model of Cox the variables related to compliance were: younger age, level of instruction lower than secondary studies, free medicines for pensioner, no psychotherapeutic treatment, consume a fewer antidepressants drugs and a frequency ≤ 3 visits to the family doctor 3 months previous to the study.


CONCLUSIONS
The non-compliance of antidepressant treatment in primary care is high from the first weeks after initiating it. The conditioning factors are related to sociodemographic characteristics and other patient characteristics as type of financing of pharmaceutical benefit and frequentness at primary care.
Centro de Salud de La Roda, Servicio de Salud de Castilla-La Mancha, La Roda, Albacete, España. Electronic address: iparraga@sescam.jccm.es.
Ignacio
I
Párraga Martínez
Centro de Salud Zona IV de Albacete, Servicio de Salud de Castilla-La Mancha, Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, Albacete, España.
Jesús
J
López-Torres Hidalgo
Centro de Salud de Almansa, Servicio de Salud de Castilla-La Mancha, Almansa, Albacete, España.
José M
JM
del Campo del Campo
Centro de Salud de San Clemente, Servicio de Salud de Castilla-La Mancha, San Clemente, Cuenca, España.
Alejandro
A
Villena Ferrer
Centro de Salud de Hellín 2, Servicio de Salud de Castilla-La Mancha, Hellín, Albacete, España.
Susana
S
Morena Rayo
Centro de Salud Zona IV de Albacete, Servicio de Salud de Castilla-La Mancha, Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, Albacete, España.
Francisco
F
Escobar Rabadán
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011320:Primary Health Care; D011446:Prospective Studies; D016903:Drug Monitoring
D000928:Antidepressive Agents
Antidepresivos; Antidepressive agents; Atención primaria de salud; Cumplimiento de la medicación; Efecto secundario; Medication adherence; Primary health care; Secondary effect