Little beneficial effect of maternal vitamin supplement on metabolic disturbances in the offspring from the obese mother mice.
OBJECTIVE
To examine whether vitamin supplement before and during pregnancy alters the detrimental effect of maternal obesity on the offspring.


METHODS
Obese C57BL/6 female mice were randomly divided into four groups and fed with the control, vitamin D, folic acid or multivitamin supplement diet before and during pregnancy. Physiologic and biochemical variables were obtained.


RESULTS
No significant differences were observed in glucose and lipid variables among offspring from each maternal obese group.


CONCLUSIONS
Overall, vitamin D, folic acid or multivitamin supplement cannot ameliorate the detrimental effect of maternal obesity on the metabolic disturbances in the offspring.
Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University , Harbin , P. R. China.
Yifan
Y
Huang
Tingting
T
Liu
Changhao
C
Sun
D000818:Animals; D001835:Body Weight; D019587:Dietary Supplements; D005260:Female; D005947:Glucose / Q000378:metabolism*; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena / Q000187:drug effects*; D008659:Metabolic Diseases / Q000503:physiopathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology*; D011247:Pregnancy; D014815:Vitamins / Q000008:administration & dosage*
D014815:Vitamins; D005947:Glucose
Diabetes; folic acid; insulin resistance; lipid disorder; transgenerational effect; vitamin D