Tetranuclear gadolinium(III) porphyrin complex as a theranostic agent for multimodal imaging and photodynamic therapy.
We describe herein the elaborate design of a Gd(III)-porphyrin complex as a theranostic agent for multimodal imaging and photodynamic therapy. Far-red-emitting (665 nm) and high relaxivity (14.1 mM(-1) s(-1)) with 107% increase upon binding to HSA (human serum albumin) (29.2 mM(-1) s(-1)) together with efficiently generating singlet oxygen upon exposure to far-red light irradiation at 650 ± 20 nm demonstrate that this Gd(III)-porphyrin complex with four Gd(III)-DTTA units bound to tetraphenylporphyrin acts as a potentially theranostic agent with excellent performance for magnetic resonance imaging, optical imaging, and photodynamic therapy.
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , 155 Yangqiao Road West, Fuzhou 350002, China.
Jian
J
Luo
Li-Feng
LF
Chen
Ping
P
Hu
Zhong-Ning
ZN
Chen
D045744:Cell Line, Tumor; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D008665:Metalloporphyrins / Q000138:chemical synthesis / Q000737:chemistry; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D064847:Multimodal Imaging; D061848:Optical Imaging; D010778:Photochemotherapy; D012709:Serum Albumin / Q000737:chemistry*; D026082:Singlet Oxygen / Q000032:analysis
D003287:Contrast Media; D008665:Metalloporphyrins; D012709:Serum Albumin; D026082:Singlet Oxygen; D005682:Gadolinium