Calcium channel autoantibodies predicted sudden cardiac death and all-cause mortality in patients with ischemic and nonischemic chronic heart failure.
The purpose of this study was to evaluate whether CC-AAbs levels could predict prognosis in CHF patients. A total of 2096 patients with CHF (841 DCM patients and 1255 ICM patients) and 834 control subjects were recruited. CC-AAbs were detected and the relationship between CC-AAbs and patient prognosis was analyzed. During a median follow-up time of 52 months, there were 578 deaths. Of these, sudden cardiac death (SCD) occurred in 102 cases of DCM and 121 cases of ICM. The presence of CC-AAbs in patients was significantly higher than that of controls (both P < 0.001). Multivariate analysis revealed that positive CC-AAbs could predict SCD (HR 3.191, 95% CI 1.598-6.369 for DCM; HR 2.805, 95% CI 1.488-5.288 for ICM) and all-cause mortality (HR 1.733, 95% CI 1.042-2.883 for DCM; HR 2.219, 95% CI 1.461-3.371 for ICM) in CHF patients. A significant association between CC-AAbs and non-SCD (NSCD) was found in ICM patients (HR = 1.887, 95% CI 1.081-3.293). Our results demonstrated that the presence of CC-AAbs was higher in CHF patients versus controls and corresponds to a higher incidence of all-cause death and SCD. Positive CC-AAbs may serve as an independent predictor for SCD and all-cause death in these patients.
State Key Laboratory of Cardiovascular Disease, Physiology and Pathophysiology Laboratory, Fu wai Cardiovascular Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, China.
Haiyun
H
Yu
State Key Laboratory of Cardiovascular Disease, Physiology and Pathophysiology Laboratory, Fu wai Cardiovascular Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, China.
Juanhui
J
Pei
State Key Laboratory of Cardiovascular Disease, Physiology and Pathophysiology Laboratory, Fu wai Cardiovascular Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, China.
Xiaoyan
X
Liu
State Key Laboratory of Cardiovascular Disease, Physiology and Pathophysiology Laboratory, Fu wai Cardiovascular Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, China.
Jingzhou
J
Chen
State Key Laboratory of Cardiovascular Disease, Physiology and Pathophysiology Laboratory, Fu wai Cardiovascular Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, China.
Xian
X
Li
State Key Laboratory of Cardiovascular Disease, Physiology and Pathophysiology Laboratory, Fu wai Cardiovascular Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, China.
Yinhui
Y
Zhang
State Key Laboratory of Cardiovascular Disease, Physiology and Pathophysiology Laboratory, Fu wai Cardiovascular Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, China.
Ning
N
Li
State Key Laboratory of Cardiovascular Disease, Physiology and Pathophysiology Laboratory, Fu wai Cardiovascular Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, China.
Zengwu
Z
Wang
People's Hospital, Peking University, Beijing 100044, China.
Ping
P
Zhang
First People's Hospital of Jiangsu Province, Nanjing 210029, China.
Kejiang
K
Cao
State Key Laboratory of Cardiovascular Disease, Physiology and Pathophysiology Laboratory, Fu wai Cardiovascular Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, China.
Jielin
0000-0003-0746-955X
J
Pu
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D020746:Calcium Channels, L-Type / Q000276:immunology*; D016022:Case-Control Studies; D002908:Chronic Disease; D016757:Death, Sudden, Cardiac; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000276:immunology / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000276:immunology / Q000401:mortality; D011379:Prognosis
D001323:Autoantibodies; D015415:Biomarkers; D020746:Calcium Channels, L-Type