Hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition.
OBJECTIVE
Hyperglycemia worsens the neuronal death induced by cerebral ischemia. Previous studies demonstrated that diabetic hyperglycemia suppressed the expression of heat shock protein 70 and 60 (HSP70 and 60) in the liver. IgG antibody titres against heat shock protein 27 (anti HSP27) were measured to determine whether hyperglycemia exacerbates ischemic brain damage by suppressing the expression of heat shock protein 27 (HSP27) in the brain.


METHODS
A randomized controlled study of traumatic brain injury ICU patients treated either by intensive insulin treatment (IIT) or by conventional glucose control (CGC) was conducted. Patients received at least 50% of their estimated daily energy requirements parenterally. Serum anti HSP27 antibody concentration was assessed at baseline, day 7 and day 14.


RESULTS
Twenty-six out of 29 patients (n=13 in each group) completed the study. At baseline, there were no differences between the two groups. On day 14, there was a significant reduction in anti HSP27 titre concentration in the IIT compared to the GCG group (0.47±0.27 mg/dl vs 0.60±0.15 mg/dl, P=0.03).


CONCLUSIONS
In this study, intensive control of traumatic brain injury patients on parenteral nutrition reduced anti HSP27 titre, possibly suggesting a reduction in stress.
Department of Nutrition, Endoscopic and Minimally Invasive Surgery, and Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyedeh Neda
SN
Mousavi
Department of Neurosurgery, Research Center of Orthopedic Surgery of Shahid Kamyab Hospital, Mashhad, Iran.
Fariborz
F
Samini
Department of Nutrition, Endoscopic and Minimally Invasive Surgery, and Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohsen
M
Nematy
Department of Life and Health Sciences, School of Sciences and Engineering, University of Nicosia, Nicosia, Cyprus.
Elena
E
Philippou
Department of Nutrition, Endoscopic and Minimally Invasive Surgery, and Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad
M
Safarian
Department of Nutrition, Endoscopic and Minimally Invasive Surgery, and Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Shima
S
Tavallaiee
Department of Nutrition, Endoscopic and Minimally Invasive Surgery, and Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Abdolreza
A
Norouzy
Glucose control; Heat shock protein 27; Parenteral nutrition; Traumatic brain injury