Double trouble--the art of synthesis of chiral dimeric natural products.
Double or nothing! Recently the total synthesis of secalonic acids A and D was reported. This work and other natural product syntheses with a dimerization step as a common feature are featured in this Highlight. The significant biological activity of the secalonic acids and the fact that their synthesis has fascinated synthetic chemists for the past forty years make this work a milestone in natural product synthesis.
Institute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany).
Tim
T
Wezeman
Kye-Simeon
KS
Masters
Stefan
S
Bräse
D001688:Biological Products / Q000138:chemical synthesis* / Q000378:metabolism; D019281:Dimerization; D015394:Molecular Structure; D044004:Xanthones / Q000138:chemical synthesis* / Q000378:metabolism
D001688:Biological Products; D044004:Xanthones; C009218:secalonic acid
Diels-Alder reactions; dimerization; natural products; oxidative coupling; secalonic acid