Safety and tolerance of a new extensively hydrolyzed rice protein-based formula in the management of infants with cow's milk protein allergy.
Guidelines recommend the use of extensively hydrolyzed cow's milk protein-based formulas (eHF) in the treatment of infants with cow's milk protein allergy (CMPA). Extensively hydrolyzed rice protein infant formula (eRHF) has recently become available and could offer a valid alternative. A prospective trial was performed to evaluate the hypo-allergenicity and safety of a new eRHF in infants with a confirmed CMPA. Patients were fed the study formula for 6 months. Clinical tolerance of the eRHF was evaluated with a symptom-based score (SBS) and growth (weight and length) was monitored. Forty infants (mean age, 3.4 months; range, 1-6 months) with CMPA confirmed by a food challenge were enrolled. All infants tolerated the eRHF and the SBS significantly decreased as of the first month of intervention. Moreover, the eRHF allowed a catch-up to normal weight gain as of the first month as well as a normalization of the weight-for-age, weight-for length, and BMI z-scores within the 6-month study period.


CONCLUSIONS
In accordance with current guidelines, this eRHF was tolerated by more than 90 % of children with proven CMPA with a 95 % confidence interval. This eRHF is an adequate and safe alternative to cow milk-based eHF.
Department of Pediatrics, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium, yvan.vandenplas@uzbrussel.be.
Yvan
Y
Vandenplas
Elisabeth
E
De Greef
Bruno
B
Hauser
D000818:Animals; D001530:Belgium; D001827:Body Height; D001835:Body Weight; D002417:Cattle; D005260:Female; D005500:Follow-Up Studies; D006128:Growth; D017408:Guidelines as Topic; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D041943:Infant Formula / Q000008:administration & dosage / Q000379:methods; D007231:Infant, Newborn; D008297:Male; D016269:Milk Hypersensitivity / Q000178:diet therapy*; D008894:Milk Proteins / Q000009:adverse effects*; D012275:Oryza; D014674:Plant Proteins, Dietary / Q000008:administration & dosage*; D011446:Prospective Studies; D011492:Protein Hydrolysates / Q000008:administration & dosage*
D008894:Milk Proteins; D014674:Plant Proteins, Dietary; D011492:Protein Hydrolysates