An investigation of lateral geniculate nucleus volume in patients with primary open-angle glaucoma using 7 tesla magnetic resonance imaging.
OBJECTIVE
To investigate lateral geniculate nucleus (LGN) volume of primary open-angle glaucoma (POAG) patients compared with age- and sex-matched controls using ultra-high field 7.0-T magnetic resonance imaging (MRI).


METHODS
The study included 18 patients with POAG and 18 age- and sex-matched healthy volunteers. All subjects underwent imaging on a high-resolution 7.0-T MRI system. Bilateral LGNs were identified and manually delineated, and LGN volumes were compared. Peripapillary retinal nerve fiber layer (pRNFL) thickness, optic nerve head parameters (including optic disc size, rim area, and cup-to-disc ratio), and combined thickness of the ganglion cell layer and inner plexus layer (GC-IPL) were measured by Cirrus high-definition optical coherence tomography (OCT). Correlations between OCT parameters and LGN volume were investigated.


RESULTS
Mean LGN volumes were significantly smaller in the POAG group than in the control group (right, glaucoma 83.97 mm(3) [SD ± 26.65] versus control 106.12 mm(3) [SD ± 24.32]; left, glaucoma 65.12 mm(3) [SD ± 29.41] versus control 92.70 mm(3) [SD ± 24.42], both P < 0.05). In the POAG group, average GC-IPL thickness was correlated with contralateral LGN volume (right LGN: r = 0.605, P = 0.008; left LGN: r = 0.471, P = 0.049). The correlation for right LGN volume remained significant after correction for multiple comparisons. However, there was no correlation between LGN volume and average pRNFL thickness or optic disc parameters in the POAG group.


CONCLUSIONS
On high-resolution 7.0-T MRI, LGN volumes in POAG patients are significantly smaller than those of healthy subjects. Furthermore, in patients, LGN volume was found to be significantly correlated with GC-IPL thickness of the contralateral eye.
Department of Ophthalmology, Gachon University, Gil Hospital, Incheon, Korea.
Jong Yeon
JY
Lee
Neuroscience Research Institute, Gachon University, Incheon, Korea.
Hye Jin
HJ
Jeong
Department of Ophthalmology, Gachon University, Gil Hospital, Incheon, Korea.
Jong Hwan
JH
Lee
Department of Ophthalmology, Gachon University, Gil Hospital, Incheon, Korea.
Yu Jeong
YJ
Kim
Department of Radiology, Gachon University, Incheon, Korea.
Eung Yeop
EY
Kim
Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Yong Yeon
YY
Kim
Neuroscience Research Institute, Gachon University, Incheon, Korea.
Taekhyun
T
Ryu
Neuroscience Research Institute, Gachon University, Incheon, Korea.
Zang-Hee
ZH
Cho
Neuroscience Research Institute, Gachon University, Incheon, Korea.
Young-Bo
YB
Kim
D005260:Female; D005500:Follow-Up Studies; D005829:Geniculate Bodies / Q000473:pathology*; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology; D011446:Prospective Studies; D015203:Reproducibility of Results
7 tesla magnetic resonance imaging; GC-IPL; ganglion cell layer; glaucoma; inner plexiform layer; lateral geniculate nucleus; optical coherence tomography; retinal nerve fiber layer thickness