Focal adhesion kinase function in neuronal development.
During the development and maturation of the adult nervous system, several consecutive events, from neural induction to axon-dendrite arborization and synapse formation, contribute to the final exquisite specificity of neuronal networks. To accomplish this precise and healthy brain architecture, a coordinated rearrangement of the cytoskeleton in response to extracellular cues is essential. In this review, we propose focal adhesion kinase (FAK) as a key intracellular component for this command, and summarize different studies that support this hypothesis. We will discuss how FAK interacts with different extracellular molecules and the cytoskeleton and how FAK functions as a sort of "orchestra conductor" coordinating a broad range of signaling pathways during neuronal motility.
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain.
Ana I
AI
Navarro
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain. Electronic address: brico@umh.es.
Beatriz
B
Rico
D000818:Animals; D002465:Cell Movement; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism*; D009420:Nervous System / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D015398:Signal Transduction
D051416:Focal Adhesion Protein-Tyrosine Kinases