First detection of CMY-2 plasmid mediated β-lactamase in Salmonella Heidelberg in South America.
Salmonella enterica serovar Heidelberg ranks among the most prevalent causes of human salmonellosis in the United States and Canada, although it has been infrequently reported in South American and European countries. Most Salmonella infections are self-limiting; however, some invasive infections require antimicrobial therapy. In this work we characterized an oxyimino-cephalosporin resistant S. Heidelberg isolate recovered from an inpatient in a Buenos Aires hospital. CMY-2 was responsible for the β-lactam resistance profile. S. Heidelberg contained a 97kb plasmid belonging to the Inc N group harboring blaCMY-2. ISEcp1 was located upstream blaCMY-2 driving its expression and mobilization. The isolate belonged to sequence type 15 and virotyping revealed the presence of sopE gene. In this study we identified the first CMY-2 producing isolate of S. Heidelberg in Argentina and even in South America.
Cátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
Daniela
D
Cejas
Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Rafael
R
Vignoli
Hospital de Infecciosas "F. Muñiz", Ciudad Autónoma de Buenos Aires, Argentina.
Mirta
M
Quinteros
Hospital de Infecciosas "F. Muñiz", Ciudad Autónoma de Buenos Aires, Argentina.
Ricardo
R
Marino
Hospital de Infecciosas "F. Muñiz", Ciudad Autónoma de Buenos Aires, Argentina.
Raquel
R
Callejo
Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Laura
L
Betancor
Cátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
Gabriel O
GO
Gutkind
Cátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: mradice@ffyb.uba.ar.
Marcela A
MA
Radice
D000328:Adult; D001118:Argentina; D001426:Bacterial Proteins / Q000235:genetics*; D004251:DNA Transposable Elements; D005759:Gastroenteritis / Q000150:complications / Q000382:microbiology; D023061:Gene Order; D005798:Genes, Bacterial; D015658:HIV Infections / Q000150:complications; D006801:Humans; D011815:R Factors / Q000235:genetics*; D012480:Salmonella Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D019779:Salmonella enterica / Q000145:classification / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D012703:Serotyping; D013020:South America / Q000453:epidemiology; D001618:beta-Lactamases / Q000235:genetics*
D001426:Bacterial Proteins; D004251:DNA Transposable Elements; C103022:beta-lactamase CMY-2; D001618:beta-Lactamases
CMY-2 β-lactamasa; CMY-2 β-lactamase; ST15; Salmonella Heidelberg