Histone phosphorylation: its role during cell cycle and centromere identity in plants.
As the main protein components of chromatin, histones can alter the structural/functional capabilities of chromatin by undergoing extensive post-translational modifications (PTMs) such as phosphorylation, methylation, acetylation, ubiquitination, sumoylation, and so on. These PTMs are thought to transmit signals from the chromatin to the cell machinery to regulate various processes. Histone phosphorylation is associated with chromosome condensation/segregation, activation of transcription, and DNA damage repair. In this review, we focus on how different histone phosphorylations mark for chromatin change during the cell cycle, the relationship between histone phosphorylation and functional centromeres, and the candidate kinases that trigger and the phosphatase or kinase inhibitors that alter histone phosphorylation. Finally, we review the crosstalk between different PTMs.
State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
B
B
Zhang
Q
Q
Dong
H
H
Su
J A
JA
Birchler
F
F
Han
D002453:Cell Cycle / Q000235:genetics*; D002503:Centromere / Q000235:genetics*; D002843:Chromatin / Q000235:genetics; D032461:Chromosomes, Plant / Q000235:genetics*; D006657:Histones / Q000235:genetics*; D006801:Humans; D010766:Phosphorylation / Q000235:genetics*; D011499:Protein Processing, Post-Translational / Q000235:genetics
D002843:Chromatin; D006657:Histones