OPHA (oxidation-Passerini-hydrolysis-alkylation) strategy: a four-step, one-pot improvement of the alkylative Passerini reaction.
Multicomponent reactions are often recognized for their efficiency and convergency, if compared with multistep organic synthesis. Nevertheless, we here demonstrate that a four-step-one-pot approach (named OPHA strategy for the initials of the four steps involved) is not only able to afford compounds that could not be obtained by an alkylative Passerini reaction but also capable of generating them with minimal loss of atoms and high operational simplicity, as in a typical multicomponent approach.
Department of Chemistry and Industrial Chemistry, University of Genova , Via Dodecaneso 31, 16146 Genova, Italy.
Fabio
F
De Moliner
Martina
M
Bigatti
Luca
L
Banfi
Renata
R
Riva
Andrea
A
Basso