Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence.
BACKGROUND
Curcumin (Cur), an active ingredient of turmeric is known to have multiple activities, including an antioxidant property and has been suggested to be useful in treatment of several neurological diseases.


OBJECTIVE
To investigate the neuroprotective effects of Cur to mitigate the effect of the Fluoride (F) induced neurotoxicity in mice brain using the histological and the biochemical parameters.


METHODS
Exposure of mice (30 days old male) to F (120 ppm) daily for 30 days.


CONCLUSIONS
Treatment with the F causes an increase in lipid peroxidation (LPO) and also increase in the neurodegenerative cells in the hippocampal sub-regions. Interestingly, co-treatment with Cur (30 mg/kg BW) with F (120 ppm) for 30 days results in significant decreases in LPO with a concomitant decrease in neurodegeneration as compared with those treated with F alone.


CONCLUSIONS
Our study reveals that Cur is useful in ameliorating degenerative effects of F in mice brain.
Department of Zoology, University College of Science, M.L. Sukhadia University, Udaipur, India.
Chhavi
C
Sharma
Department of Zoology, University College of Science, M.L. Sukhadia University, Udaipur, India.
Pooja
P
Suhalka
Department of Zoology, University College of Science, M.L. Sukhadia University, Udaipur, India.
Piyu
P
Sukhwal
Department of Zoology, University College of Science, M.L. Sukhadia University, Udaipur, India.
Neha
N
Jaiswal
Department of Zoology, University College of Science, M.L. Sukhadia University, Udaipur, India.
Maheep
M
Bhatnagar
Curcumin; fluoride; histology.; lipid peroxidation; neurodegeneration; neuroprotection; oxidative stress