New approaches to the diagnosis and treatment of cryptococcal meningitis.
Cryptococcal meningitis remains one of the leading causes of morbidity and mortality among immunosuppressed individuals, particularly those with advanced acquired immunodeficiency syndrome. The greatest burden of disease is in sub-Saharan Africa and Asia where there is limited access to diagnostics and treatment for the disease. The authors review the available tools for diagnosing cryptococcal meningitis and review treatment for cryptococcal meningitis, highlighting the evidence behind current treatment guidelines.
Department of Ragon Institute of MGH, MIT and Harvard, Medicine Harvard Medical School, Boston, Massachusetts.
Azure T
AT
Makadzange
Department of Medicine, Parirenyatwa Hospital Family Care Centre, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Grace
G
McHugh
D006678:HIV / Q000472:pathogenicity*; D006801:Humans; D016919:Meningitis, Cryptococcal / Q000175:diagnosis* / Q000628:therapy*