Exhaled nitric oxide in interstitial lung diseases.
Nitric oxide (NO) is a biomarker of nitrosative stress, which is involved in the pathogenesis of idiopathic interstitial pneumonias (IIP). This study evaluates exhaled NO levels in IIP patients and relates alveolar concentrations of NO (CalvNO) to pulmonary function test (PFT) and 6-minute walking test (6MWT) parameters. We measured fractional exhaled nitric oxide (FeNO), CalvNO and maximum conducting airway wall flux (J'awNO) in 30 healthy subjects and 30 patients with IIP (22 idiopathic pulmonary fibrosis and 8 idiopathic non-specific interstitial pneumonias). IIP patients had higher FeNO at flow rates of 50-100-150 ml/s and higher CalvNO levels than healthy controls (p<0.0001). CalvNO was significantly correlated with 6-minute walking distance (p<0.0001), recovery time (p<0.0005), TLC (p<0.001), FVC (p=0.01) and TLCO (p<0.01). IIP patients showed abnormal nitric oxide production, probably due to lung fibrosis and oxidative-mediated lung injury. CalvNO was correlated with PFT and 6MWT parameters and is proposed as a potential biomarker of lung fibrosis and exercise tolerance.
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplantation Section, Le Scotte Hospital, Siena, Italy. Electronic address: paolocameli88@gmail.com.
P
P
Cameli
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplantation Section, Le Scotte Hospital, Siena, Italy.
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E
Bargagli
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplantation Section, Le Scotte Hospital, Siena, Italy.
R M
RM
Refini
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplantation Section, Le Scotte Hospital, Siena, Italy.
M G
MG
Pieroni
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplantation Section, Le Scotte Hospital, Siena, Italy.
D
D
Bennett
Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplantation Section, Le Scotte Hospital, Siena, Italy.
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P
Rottoli
D015415:Biomarkers / Q000378:metabolism; D001944:Breath Tests; D005080:Exercise Test; D045853:Exhalation; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000378:metabolism*; D017563:Lung Diseases, Interstitial / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis*; D012129:Respiratory Function Tests; D013997:Time Factors; D016138:Walking
D015415:Biomarkers; D009569:Nitric Oxide
Idiopathic pulmonary fibrosis; Nitric oxide; Nitrosative stress; Non-specific interstitial pneumonia; Oxidative stress; biomarker