Relationship between target organ damage and blood pressure, retinal vessel calibre, oxidative stress and polymorphisms in VAV-2 and VAV-3 genes in patients with hypertension: a case-control study protocol (LOD-Hipertension).
BACKGROUND
Target organ damage (TOD) is associated with increased cardiovascular risk. The study objectives were to analyse the relationship of TOD to blood pressure, size of retinal arteries and veins, oxidative stress and different polymorphisms in the VAV-2 and VAV-3 genes in participants with hypertension.


METHODS
A case-control study to analyse the relationship between clinical, biochemical and genetic parameters and presence of cardiac, vascular and renal TOD in 486 patients with hypertension. Participants with TOD will be considered as cases, and those without TOD will be enrolled as controls. This will be a collaborative study conducted by the groups of Primary Care, Cardiovascular and Metabolic and Degenerative Diseases of the Instituto de Investigación Biomédica of Salamanca (IBSAL). Assessment of cardiac, renal and vascular TOD. Measurement of peripheral and central blood pressure, size of eye fundus arteries and veins, and oxidative stress, and polymorphisms in the VAV-2 and VAV-3 genes.


BACKGROUND
The study will be conducted after approval is obtained from the Ethics Committee of Hospital Clínico Universitario of Salamanca. All study participants will sign an informed consent to agree to participate in the study, and another consent to agree on the genetic study, in compliance with the Declaration of Helsinki and the WHO standards for observational studies. The results of this study will allow for an understanding of the relationship of the different TODs with blood pressure, retinal artery and vein diameters, oxidative stress and polymorphisms in VAV-2 and VAV-3 genes.


BACKGROUND
Clinical Trials. gov Identifier: NCT02022618.
Instituto de Investigación Biomédica de Salamanca (IBSAL). Primary Care Research Unit, La Alamedilla Health Center, Castilla and León Health Service-SACYL, Salamanca, Spain.
Manuel A
MA
Gomez-Marcos
Rogelio
R
Gonzalez-Sarmiento
José I
JI
Recio-Rodríguez
Cristina
C
Agudo-Conde
Luis
L
Gamella-Pozuelo
Nuria
N
Perretta-Tejedor
Carlos
C
Martínez-Salgado
Luis
L
García-Ortiz
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000503:physiopathology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011110:Polymorphism, Genetic; D051567:Proto-Oncogene Proteins c-vav / Q000235:genetics*; D012171:Retinal Vessels / Q000473:pathology*; D012307:Risk Factors; D055815:Young Adult
D051567:Proto-Oncogene Proteins c-vav; C093651:VAV2 protein, human; C496621:VAV3 protein, human
Blood pressure; Oxidative stress; Polymorphisms.; Retinal arteries and veins; Target organ damage