On the origin of leukemic species.
Recent studies (Shlush et al., 2014; Corces-Zimmerman et al., 2014) have demonstrated that leukemias develop from hematopoietic stem cells that acquire preleukemic mutations, allowing clonal expansion and subsequent acquisition of mutations leading to cancer. Preleukemic cells survive chemotherapy and serve as reservoirs for disease, generating new clones and leading to relapse.
Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Aparna
A
Vasanthakumar
Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. Electronic address: lgodley@medicine.bsd.uchicago.edu.
Lucy A
LA
Godley
D000818:Animals; D060965:Clonal Evolution / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000737:chemistry* / Q000166:cytology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology*; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000166:cytology*; D011289:Preleukemia / Q000235:genetics*