Resveratrol-induced potentiation of the antitumor effects of oxaliplatin is accompanied by an altered cytokine profile of human monocyte-derived macrophages.
The objective of this study was to investigate, whether the naturally occurring polyphenol resveratrol (Res) enhances the anti-tumor activities of the chemotherapeutic agent oxaliplatin (Ox) in a cell culture model of colorectal cancer, also with regard to a possible inflammatory response and cytotoxic side-effects. Res and Ox in combination synergistically inhibit cell growth of Caco-2 cells, which seems to be due to the induction of different modes of cell death and further leads to an altered cytokine profile of cocultured macrophages. Moreover, combinatorial treatment does not affect non-transformed cells as severe cytotoxicity is not detected in human foreskin fibroblasts and platelets.
Institute of Pharmaceutical Chemistry, Biozentrum, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.
Bettina M
BM
Kaminski
Andreas
A
Weigert
Maria-Christina
MC
Scherzberg
Stephanie
S
Ley
Bianca
B
Gilbert
Kerstin
K
Brecht
Bernhard
B
Brüne
Dieter
D
Steinhilber
Jürgen
J
Stein
Sandra
S
Ulrich-Rückert
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D018938:Caco-2 Cells; D018920:Coculture Techniques; D015179:Colorectal Neoplasms; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D004357:Drug Synergism; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D009944:Organoplatinum Compounds / Q000494:pharmacology* / Q000633:toxicity; D000077150:Oxaliplatin; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000633:toxicity; D059467:Transcriptome
D000970:Antineoplastic Agents; D016207:Cytokines; D009944:Organoplatinum Compounds; D013267:Stilbenes; D000077150:Oxaliplatin; D000077185:Resveratrol