Mantle cell lymphoma with in situ or mantle zone growth pattern: a study of five cases and review of literature.
We present two rare cases of in situ mantle cell lymphoma ("in situ MCL") and three cases of MCL with mantle zone growth pattern (MCL-MZGP). The patients include four males and one female, with a median age of 66 years (range, 52 to 86 years). Two present with isolated lymphadenopathy and three with multiple lymphadenopathy. At presentation, the complete blood count (CBC) and serum lactate dehydrogenase (LDH) are normal in all cases. Histologic examination reveals an in situ pattern in two cases and a mantle zone growth pattern in three cases. The staging bone marrow biopsies show minimal involvement by lymphoma in one case and no morphologic evidence of lymphoma in four cases. All cases are positive for cyclin D1, including two with typical MCL phenotype and three with CD5-negativity. Four out of five cases express kappa light chain. FISH study for t(11;14) is performed in three cases, of which one is positive and two are inconclusive. For four patients with a median follow-up of 38 months, three are in clinical remission and one has persistent disease. In conclusion, the "in situ MCL" is associated with incidental finding, indolent clinical course and lower tumor burden. The predominant usage of kappa light chain and frequent CD5-negativity observed in our cases are unusual. We review the clinical and laboratory features of "in situ MCL" cases in the literature.
Department of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Peihong
P
Hsu
Department of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Tianyu
T
Yang
Department of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Silvat
S
Sheikh-Fayyaz
Department of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Judith
J
Brody
Department of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Jela
J
Bandovic
Department of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Sarma
S
Roy
Department of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Jordan
J
Laser
Department of Internal Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Jonathan E
JE
Kolitz
Department of Internal Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Craig
C
Devoe
Department of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Xinmin
X
Zhang
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged
Mantle cell lymphoma; in situ mantle cell lymphoma; t(11;14)