Genome-wide genetic study in autoimmune disease-prone mice.
Mouse models of autoimmune diseases provide invaluable insights into the cellular and molecular bases of autoimmunity. Genetic linkage studies focusing on their abnormal quantitative phenotypes in relation to the loss of self-tolerance will lead to the identification of polymorphic genes that play pivotal roles in the genetic predisposition to autoimmunity. In this chapter, we first overview the basic concepts in the statistical genetics and then provide guides to genotyping microsatellite DNA markers and to quantitative trait loci mapping using a MAPMAKER program.
Department of Bioengineering, Toin Human Science and Technology Center, Toin University of Yokohama, 1614 Kurogane-cho Aoba-ku, Yokohama, 225-8502, Japan.
Masaomi
M
Obata
Mareki
M
Ohtsuji
Yukiyasu
Y
Iida
Toshikazu
T
Shirai
Sachiko
S
Hirose
Hioroyuki
H
Nishimura
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D016678:Genome; D023281:Genomics / Q000379:methods; D005838:Genotype; D016013:Likelihood Functions; D051379:Mice; D018895:Microsatellite Repeats; D040641:Quantitative Trait Loci; D012984:Software
D005819:Genetic Markers