Evaluation of brainstem involvement in multiple sclerosis.
OBJECTIVE
the aim of the present study was to determine the optimum method to detect brainstem lesions in patients with Multiple Sclerosis (MS).


METHODS
72 patients with the diagnosis of relapsing-remitting MS were prospectively included. brainstem functional system score (bSfS) (part of the expanded disability status scale (edSS) evaluating brainstem symptomatology) was calculated. Magnetic resonance imaging (Mri) was performed on 1.5t and t1, t2, pd and fluid-attenuated inversion recovery (flair) sequences were analyzed for presence of brainstem lesions. auditory evoked potentials (aep) and ocular and cervical vestibular evoked myogenic potentials (oVeMp and cVeMp) were performed according to the standardized protocol.


RESULTS
from 72 patients, 18 (25%) had clinical involvement of the brainstem. Mri showed brainstem involvement in 29 (40%) patients. of the neurophysiological tests, aep showed pathological result in 16 (22%) patients, oVeMp in 36 (50%) patients, cVeMp in 18 (25%) patients, and VeMp (combination of oVeMp and cVeMp) in 45 (63%) patients. VeMp detected brainstem lesions in higher percentage than clinical examination, Mri and aep, which was statistically significant (< 0.0001, 0.012 and < 0.0001, respectively).


CONCLUSIONS
results of the present study have shown that VeMps are the optimal method to detect brainstem lesions in multiple sclerosis and that they detect them significantly better than clinical examination, aep or Mri.
Magdalena Krbot
MK
Skorić
Ivan
I
Adamec
Vesna Nesek
VN
Mađarić
Mario
M
Habek
D000161:Acoustic Stimulation / Q000379:methods*; D000293:Adolescent; D000328:Adult; D001933:Brain Stem / Q000473:pathology* / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology; D011446:Prospective Studies; D055815:Young Adult