Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery.
We encapsulated gadolinium oxide (Gd2O3) nanoparticles within phospholipid micelles as a novel low cytotoxic T1-weighted MRI imaging contrast agent (MGdNPs) that can also deliver small molecules such as DNA plasmids. MGdNPs show relatively good MRI relaxivity values, negligible cytotoxicity, excellent cellular uptake and expression of DNA plasmidsin vivo. Biodistribution studies in mice show that intranasal and intraperitoneal administration of MGdNPs can effectively target specific organs.
Nanomedicine Research Center, USF Morsani College of Medicine, Tampa, FL, USA. ; Tel: +1-813-974-8568.
Suraj
S
Dixit
Nanomedicine Research Center, USF Morsani College of Medicine, Tampa, FL, USA. ; Tel: +1-813-974-8568 ; Department of Internal Medicine, Division of Translational Medicine, USF Morsani College of Medicine, Tampa, FL, USA.
Mahasweta
M
Das
Nanomedicine Research Center, USF Morsani College of Medicine, Tampa, FL, USA. ; Tel: +1-813-974-8568.
Subbiah
S
Alwarappan
Nanomedicine Research Center, USF Morsani College of Medicine, Tampa, FL, USA. ; Tel: +1-813-974-8568.
Nancy L
NL
Goicochea
Department of Molecular Medicine, USF Morsani College of Medicine, Tampa, FL, USA.
Mark
M
Howell
Nanomedicine Research Center, USF Morsani College of Medicine, Tampa, FL, USA. ; Tel: +1-813-974-8568 ; Department of Molecular Medicine, USF Morsani College of Medicine, Tampa, FL, USA ; James A Haley Veteran's Hospital and Medical Research Center, Tampa, FL, USA.
Subhra
S
Mohapatra
Nanomedicine Research Center, USF Morsani College of Medicine, Tampa, FL, USA. ; Tel: +1-813-974-8568 ; Department of Internal Medicine, Division of Translational Medicine, USF Morsani College of Medicine, Tampa, FL, USA ; James A Haley Veteran's Hospital and Medical Research Center, Tampa, FL, USA.
Shyam
S
Mohapatra