Dispositional cognitive reappraisal modulates the neural correlates of fear acquisition and extinction.
Adverse learning experiences play a significant role in the etiology of anxiety disorders. However, not all individuals experiencing negative events develop heightened anxiety. This is possibly due to individual differences in the regulation of negative emotions associated with these negative events. Cognitive reappraisal is defined as reinterpreting an emotion-eliciting situation in a way that changes its emotional impact. A more frequent use of cognitive reappraisal in daily life has been shown to be more adaptive. However, no study to date examined the association of dispositional cognitive reappraisal with emotional learning, in order to elucidate individual differences in negative emotional responses towards aversive events. The goal of this functional magnetic resonance imaging (fMRI) study was to investigate the association of dispositional cognitive reappraisal with subjective, electrodermal and neural correlates of fear acquisition and extinction. Data of 41 healthy individuals, who participated in a socially relevant differential conditioning paradigm (acquisition and extinction learning: day 1, extinction recall: day 2), were acquired. Dispositional cognitive reappraisal was negatively associated with right insula, and hippocampus activation during acquisition. Furthermore, the reduction of self-reported conditioned fear during extinction learning as well as reduced insula and enhanced rostral anterior cingulate cortex activation during extinction learning was related to cognitive reappraisal. In addition, reduced recovery of conditioned arousal, reduced anterior cingulate and dorsomedial prefrontal cortex activation and enhanced ventromedial prefrontal cortex activation during extinction recall was observed in individuals with higher cognitive reappraisal scores. The results indicate that dispositional cognitive reappraisal modulates subjective and neural correlates of fear conditioning, probably leading to reduced acquisition and stronger extinction learning and recall. These results point to the important role of dispositional cognitive reappraisal in the development and modification of conditioned emotional responses and might further improve our understanding of anxiety disorders.
Department of Psychotherapy and Systems Neuroscience and Bender Institute of Neuroimaging, Justus Liebig University Giessen, Otto-Behaghel-Strasse 10F, 35394 Giessen, Germany. Electronic address: Andrea.Hermann@psychol.uni-giessen.de.
Andrea
A
Hermann
Department of Psychotherapy and Systems Neuroscience and Bender Institute of Neuroimaging, Justus Liebig University Giessen, Otto-Behaghel-Strasse 10F, 35394 Giessen, Germany.
Tanja
T
Keck
Department of Psychotherapy and Systems Neuroscience and Bender Institute of Neuroimaging, Justus Liebig University Giessen, Otto-Behaghel-Strasse 10F, 35394 Giessen, Germany.
Rudolf
R
Stark
D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology*; D005239:Fear / Q000502:physiology*; D005260:Female; D059907:Functional Neuroimaging; D005712:Galvanic Skin Response / Q000502:physiology; D006801:Humans; D007600:Judgment / Q000502:physiology*; D008032:Limbic System / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall / Q000502:physiology; D055815:Young Adult
Amygdala; Conditioning; Emotion regulation; Extinction; Reappraisal; Ventromedial prefrontal cortex; fMRI