Immunoglobulin G in IgE-mediated allergy and allergen-specific immunotherapy.
Allergen-specific IgG antibodies play a significant role in allergen-specific tolerance, either naturally induced or generated by specific immunotherapy. Nevertheless, the underlying mechanisms are still debated, and allergen-specific IgG determinations are not recommended as a diagnostic tool in IgE-mediated allergy. This review summarizes the latest findings on the immunological and diagnostic role of IgG antibodies in respiratory and food allergies, and during allergen-specific immunotherapy.
Department of Pediatric Pneumology and Immunology, Charitá Medical School, Berlin, Germany. stephanie.hofmaier@charite.de.
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Hofmaier
Department of Pediatrics, University of Verona, G.B. Rossi Polyclinic, Verona, Italy.
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Comberiati
Department of Pediatric Pneumology and Immunology, Charité Medical School, Berlin, Germany.
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Matricardi
D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000175:diagnosis / Q000276:immunology; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000276:immunology; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood*
D000485:Allergens; D007074:Immunoglobulin G; D007073:Immunoglobulin E
Allergy; Immunoglobulin G; diagnosis; specific immunotherapy; tolerance