Preparation and antibacterial activity studies of degraded polysaccharide selenide from Enteromorpha prolifera.
Polysaccharide extracted from Enteromorpha prolifera possessed excellent biological activities, but its molecular weight was greatly high which influenced the activity. Organic Se had higher biological activities and was safer than inorganic Se species. In the present study, degraded polysaccharide selenide (Se-LEP) was synthesized from sodium selenite and degraded polysaccharide (LEP) with the catalysis of nitric acid. The preparation conditions of LEP and Se-LEP were optimized by orthogonal experiments. The selenite ester group was formed, and the selenium content was 1335.27 µg/g. The thermal stability of Se-LEP decreased. LEP had less inhibitory effects on bacteria and plant pathogenic fungi. Se-LEP had stronger inhibitory effect on Eschetichia coli, and weaker inhibitory effect on Staphylococcus aureus than polysaccharide selenide (Se-EP). Se-LEP also had better inhibitory effects on plant pathogenic fungi.
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China. Electronic address: htlu6@sina.com.
Haitao
H
Lü
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China.
Yujie
Y
Gao
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China.
Hu
H
Shan
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China.
Yingting
Y
Lin
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology*; D012643:Selenium / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013696:Temperature; D044445:Ulva / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D011134:Polysaccharides; D012643:Selenium
Antibacterial activity; Degraded polysaccharide selenide; Enteromorpha prolifera