PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion.
Male BALB/c mice fed with either a regular or high fat diet were exposed to 0, 5 or 20 mg/kg perfluorooctane sulfonate (PFOS) for 14 days. Increased body weight, serum glucose, cholesterol and lipoprotein levels were observed in mice given a high fat diet. However, all PFOS-treated mice got reduced levels of serum lipid and lipoprotein. Decreasing liver glycogen content was also observed, accompanied by reduced serum glucose levels. Histological and ultrastructural examination detected more lipid droplets accumulated in hepatocytes after PFOS exposure. Moreover, transcripitonal activity of lipid metabolism related genes suggests that PFOS toxicity is probably unrelevant to PPARα's transcription. The present study demonstrates a lipid disturbance caused by PFOS and thus point to its role in inhibiting the secretion and normal function of low density lipoproteins.
1] State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P. O. Box 2871, Beijing 100085, P. R. China [2] Key Laboratory of Subtropical Agriculture and Environment, Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, P. R. China.
Ling
L
Wang
1] Key Laboratory of Subtropical Agriculture and Environment, Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, P. R. China [2] Department of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China.
Yu
Y
Wang
1] School of Medicine, Jianghan University, Wuhan 430056, P. R. China [2] Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University, Wuhan 430056, P. R. China.
Yong
Y
Liang
School of Medicine, Jianghan University, Wuhan 430056, P. R. China.
Jia
J
Li
School of Medicine, Jianghan University, Wuhan 430056, P. R. China.
Yuchen
Y
Liu
Key Laboratory of Subtropical Agriculture and Environment, Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, P. R. China.
Jie
J
Zhang
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P. O. Box 2871, Beijing 100085, P. R. China.
Aiqian
A
Zhang
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P. O. Box 2871, Beijing 100085, P. R. China.
Jianjie
J
Fu
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P. O. Box 2871, Beijing 100085, P. R. China.
Guibin
G
Jiang
D017738:Alkanesulfonic Acids / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat; D004958:Estradiol / Q000097:blood; D005466:Fluorocarbons / Q000633:toxicity*; D006003:Glycogen / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D047493:PPAR alpha / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D017738:Alkanesulfonic Acids; D005466:Fluorocarbons; D008077:Lipoproteins, LDL; D047493:PPAR alpha; D013739:Testosterone; D004958:Estradiol; D006003:Glycogen; C076994:perfluorooctane sulfonic acid