Sesquiterpenes from the saprotrophic fungus Granulobasidium vellereum (Ellis & Cragin) Jülich.
Twelve sesquiterpenes comprising either the protoilludane or the rare cerapicane carbon skeletons were obtained from the saprotrophic wood decomposing fungus Granulobasidium vellereum; 2a-hydroxycoprinolone (1), 3-hydroxycoprinolone (2), coprinolone diol B (3), granulodiene A (4), granulodiene B (5), granulone A (6), 8-deoxy-4a-hydroxytsugicoline B (7), granulone B (8), demethylgranulone (9), cerapicolene (10), as well as the known compounds radudiol and Δ(6)-coprinolone. The structures were determined using spectroscopic methods and biosynthetic considerations. Granulone A had growth stimulating effect on the total elongation of lettuce seedlings. None of the isolated compounds showed any antifungal effect.
Department of Chemistry and Biotechnology, Uppsala BioCenter, Swedish University of Agricultural Sciences, P.O. Box 7015, SE-75007 Uppsala, Sweden.
Christina L
CL
Nord
Department of Forest Mycology and Plant Pathology, Uppsala BioCenter, Swedish University of Agricultural Sciences, P.O. Box 7026, SE-75007 Uppsala, Sweden.
Audrius
A
Menkis
Department of Chemistry and Biotechnology, Uppsala BioCenter, Swedish University of Agricultural Sciences, P.O. Box 7015, SE-75007 Uppsala, Sweden.
Christofer
C
Lendel
Department of Forest Mycology and Plant Pathology, Uppsala BioCenter, Swedish University of Agricultural Sciences, P.O. Box 7026, SE-75007 Uppsala, Sweden.
Rimvydas
R
Vasaitis
Department of Chemistry and Biotechnology, Uppsala BioCenter, Swedish University of Agricultural Sciences, P.O. Box 7015, SE-75007 Uppsala, Sweden. Electronic address: Anders.Broberg@slu.se.
Anders
A
Broberg
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry* / Q000187:drug effects*; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013045:Species Specificity; D013237:Stereoisomerism
D000935:Antifungal Agents; D012717:Sesquiterpenes
Cerapicane; Granulobasidium vellereum; Growth promotor; Protoilludane; Sesquiterpenes; Structural elucidation