Anti-MOG antibodies in adult patients with demyelinating disorders of the central nervous system.
The myelin oligodendrocyte glycoprotein (MOG) is considered as a candidate marker of demyelinating disorders of the central nervous system. Here, sera samples from 48 consecutive Japanese patients with myelitis or optic neuritis (ON), but negative for anti-aquaporin (AQP) 4 antibodies (Abs), and 14 anti-AQP4 Ab-positive patients were tested for anti-MOG Abs using a cell-based immunofluorescence assay with full-length human MOG cDNA. Anti-MOG Abs were detected in four male patients with myelitis or ON. Oveall, 13 neuromyelitis optica-seronegative and all anti-AQP4 Ab-positive patients were negative for anti-MOG Abs. Hence, these findings warrant further examinations in large cohort series.
Multiple Sclerosis Center, Utano National Hospital, 8 Ondoyama-machi, Ukyo-ku, Kyoto, 616-8255, Japan. Electronic address: tanaka@unh.hosp.go.jp.
Masami
M
Tanaka
Department of Neurology, Kanazawa Medical University, Uchinada, Ishikawa, 920-0265, Japan.
Keiko
K
Tanaka
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000276:immunology*; D009188:Myelitis, Transverse / Q000097:blood / Q000276:immunology*; D009902:Optic Neuritis / Q000097:blood / Q000276:immunology*; D055815:Young Adult
D001323:Autoantibodies; D001324:Autoantigens; C571326:MOG protein, human; D063308:Myelin-Oligodendrocyte Glycoprotein
Anti- myelin oligodendrocyte glycoprotein antibodies; Anti-aquaporin 4 antibodies; Cell-based immunofluorescence assay; Multiple sclerosis; Neuromyelitis optica; Optic neuritis