Discovery of 2'-hydroxychalcones as autophagy inducer in A549 lung cancer cells.
A series of 2'-hydroxychalcone derivatives was synthesized and the effects of all the compounds on growth of A549 lung cancer cell were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound possessed the highest growth inhibitory effect and induced autophagy of A549 lung cancer cells.
Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, P.R. China. bxzhao@sdu.edu.cn miaojy@sdu.edu.cn.
Fang-Wu
FW
Wang
Sheng-Qing
SQ
Wang
Bao-Xiang
BX
Zhao
Jun-Ying
JY
Miao
D017209:Apoptosis / Q000187:drug effects; D001343:Autophagy / Q000187:drug effects*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D055808:Drug Discovery; D006801:Humans; D020128:Inhibitory Concentration 50; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008175:Lung Neoplasms / Q000473:pathology*; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009336:Necrosis
D047188:Chalcones; C477012:MAP1LC3A protein, human; D008869:Microtubule-Associated Proteins; D007770:L-Lactate Dehydrogenase; C013031:2'-hydroxychalcone