Identification of intermediate-risk patients with acute symptomatic pulmonary embolism.
The identification of normotensive patients with acute pulmonary embolism (PE) at high risk of adverse PE-related clinical events (i.e. intermediate-risk group) is a major challenge. We combined individual patient data from six studies involving 2874 normotensive patients with PE. We developed a prognostic model for intermediate-risk PE based on the clinical presentation and the assessment of right ventricular dysfunction and myocardial injury. We used a composite of PE-related death, haemodynamic collapse or recurrent PE within 30 days of follow-up as the main outcome measure. The primary outcome occurred in 198 (6.9%) patients. Predictors of complications included systolic blood pressure 90-100 mmHg (adjusted odds ratio (aOR) 2.45, 95% CI 1.50-3.99), heart rate ≥ 110 beats per min (aOR 1.87, 95% CI 1.31-2.69), elevated cardiac troponin (aOR 2.49, 95% CI 1.71-3.69) and right ventricular dysfunction (aOR 2.28, 95% CI 1.58-3.29). We used these variables to construct a multidimensional seven-point risk index; the odds ratio for complications per one-point increase in the score was 1.55 (95% CI 1.43-1.68; p<0.001). The model identified three stages (I, II and III) with 30-day PE-related complication rates of 4.2%, 10.8% and 29.2%, respectively. In conclusion, a simple grading system may assist clinicians in identifying intermediate-risk PE.
Dept of Medicine, University Hospital of Cosenza, Cosenza, Italy.
Carlo
C
Bova
Université Paris Descartes, Sorbonne Paris Cité, Paris, France Division of Respiratory and Intensive Care Medicine, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
Olivier
O
Sanchez
Dept of Medicine, Thromboembolism Unit, University Hospital of Padua, Padua, Italy.
Paolo
P
Prandoni
Center for Thrombosis and Hemostasis, University of Mainz, Mainz, Germany.
Mareike
M
Lankeit
Center for Thrombosis and Hemostasis, University of Mainz, Mainz, Germany.
Stavros
S
Konstantinides
Emergency Dept, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Simone
S
Vanni
Respiratory Dept, Ramón y Cajal Hospital, IRYCIS, Madrid, Spain djc_69_98@yahoo.com.
David
D
Jiménez
D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D009202:Cardiomyopathies / Q000150:complications / Q000175:diagnosis; D020000:Decision Support Systems, Clinical; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000150:complications / Q000175:diagnosis