The phylogenetics of dynamics in DNA clamp proteins.
Using HXMS to measure protein dynamics, Fang and colleagues (in this issue of Structure) probe the dynamics of processivity clamp proteins from all kingdoms of life. The proteins have similar structures but divergent sequences. Their results show conserved dynamics correlating with primary functions and divergent dynamics for divergent functions.
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0378, USA.
Deepa
D
Balasubramaniam
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0378, USA. Electronic address: ekomives@ucsd.edu.
Elizabeth A
EA
Komives
D004258:DNA Polymerase III / Q000737:chemistry*; D006801:Humans; D056004:Molecular Dynamics Simulation
D004258:DNA Polymerase III