Niosomes from glucuronic acid-based surfactant as new carriers for cancer therapy: preparation, characterization and biological properties.
Niosomes are vesicular systems composed of surfactant molecules, claimed to be used as drug delivery carriers thanks to their physico-chemical and biological properties. The aim of this work was to design niosomes obtained with a surfactant synthesized from glucuronic acid. Doxorubicin and 5FU were used as model drugs. Niosomes were prepared with different ratios between surfactant and cholesterol, and characterized in terms of size, morphology, drugs entrapment efficiency and in vitro releases, to identify the optimal formulation to be used in pharmaceutical fields. In addition, the hemolytic activity of all formulations have been also evaluated. Results showed that dodecylglucuronamide surfactant was able to produce vesicular systems with or without the presence of cholesterol. Niosomes resulted regular in size and shape and they have been found to encapsulate and release in a controlled manner both doxorubicin and 5-fluorouracil. Hemolytic tests showed that the capability of disrupting erythrocyte only depend on the size of colloidal aggregates. Finally, our formulations could be potentially used as antitumoral delivery systems in anticancer therapy.
Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende, 87036 Cosenza, Italy; Dipartimento di Ingegneria Informatica, Modellistica, Elettronica e Sistemistica, Università della Calabria, Via P. Bucci Cubo 39/C, Arcavacata di Rende, 87036 Cosenza, Italy.
Lorena
L
Tavano
Dipartimento di Scienze della Salute, Università Magna Graecia, Via T. Campanella 115, 88100 Catanzaro, Italy.
Rossana
R
Aiello
Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende, 87036 Cosenza, Italy.
Giuseppina
G
Ioele
Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende, 87036 Cosenza, Italy.
Nevio
N
Picci
Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende, 87036 Cosenza, Italy. Electronic address: rita.muzzalupo@unical.it.
Rita
R
Muzzalupo
D000970:Antineoplastic Agents / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology / Q000627:therapeutic use; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D005472:Fluorouracil / Q000494:pharmacology / Q000627:therapeutic use; D020723:Glucuronic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D057446:Hydrodynamics; D008081:Liposomes / Q000138:chemical synthesis* / Q000737:chemistry / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors
D000970:Antineoplastic Agents; D004337:Drug Carriers; D008081:Liposomes; D013501:Surface-Active Agents; D004317:Doxorubicin; D020723:Glucuronic Acid; D005472:Fluorouracil
5-Fluorouracil; Doxorubicin; Glucuronic acid; Hemolysis; Niosomes