Paracoccidioidomycosis in Mexico: clinical and epidemiological data from 93 new cases (1972-2012).
Paracoccidioidomycosis (PCM) is an endemic systemic infection in several countries of Latin America. The few registered cases in Mexico most likely do not reflect the real frequency. Disseminate the epidemiological and clinical data of unreported cases of PCM in Mexico from 1972 until 2012 is the aim of this work. Epidemiological and clinical information of non-published cases of PCM was requested from the principal mycological diagnosis centres in Mexico. A total of 93 cases were received. The infection was found predominantly in men (95.7%), peasants (88.5%) and individual between 31 and 60 years of age. Most of the cases were found in tropical areas of the Gulf of Mexico (54.84%) and the Pacific littoral (20.3%). The main sites of dissemination were the oral mucosa (39.38%) and skin (34.05%). The most effective treatments were itraconazole alone and the combination of itraconazole with sulfamethoxazole-trimethoprim. PCM is a subdiagnosed pathology in Mexico. Therefore, adequate training is necessary to determine the current status of this mycosis.
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D. F., México.
Rubén
R
López-Martínez
Francisca
F
Hernández-Hernández
Luis Javier
LJ
Méndez-Tovar
Patricia
P
Manzano-Gayosso
Alexandro
A
Bonifaz
Roberto
R
Arenas
María Del Carmen
Mdel C
Padilla-Desgarennes
Roberto
R
Estrada
Guadalupe
G
Chávez
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009061:Mouth Mucosa / Q000382:microbiology; D016273:Occupational Exposure; D010229:Paracoccidioidomycosis / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology*; D012737:Sex Factors; D012867:Skin / Q000382:microbiology; D019371:Topography, Medical; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D055815:Young Adult
D000935:Antifungal Agents; D017964:Itraconazole; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
Paracoccidioides brasiliensis; Paracoccidioidomycosis; systemic mycosis