The role of imaging in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline.
OBJECTIVE
Which imaging techniques most accurately differentiate true tumor progression from pseudo-progression or treatment related changes in patients with previously diagnosed glioblastoma?


METHODS
These recommendations apply to adults with previously diagnosed glioblastoma who are suspected of experiencing progression of the neoplastic process.
Magnetic resonance imaging with and without gadolinium enhancement is recommended as the imaging surveillance method to detect the progression of previously diagnosed glioblastoma.


METHODS
Magnetic resonance spectroscopy is recommended as a diagnostic method to differentiate true tumor progression from treatment-related imaging changes or pseudo-progression in patients with suspected progressive glioblastoma.


METHODS
The routine use of positron emission tomography to identify progression of glioblastoma is not recommended.


METHODS
Single-photon emission computed tomography imaging is recommended as a diagnostic method to differentiate true tumor progression from treatment-related imaging changes or pseudo-progression in patients with suspected progressive glioblastoma.
Department of Neurosurgery, Iowa Spine and Brain Institute, Waterloo, IA, USA, timothy-ryken@uiowa.edu.
Timothy Charles
TC
Ryken
Nafi
N
Aygun
Johnathan
J
Morris
Marin
M
Schweizer
Rajeshwari
R
Nair
Cassandra
C
Spracklen
Steven N
SN
Kalkanis
Jeffrey J
JJ
Olson
D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D018450:Disease Progression; D019317:Evidence-Based Medicine; D005682:Gadolinium; D005909:Glioblastoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D049268:Positron-Emission Tomography; D015899:Tomography, Emission-Computed, Single-Photon
D005682:Gadolinium