New flavonoids from Campylotropis hirtella with immunosuppressive activity.
In an effort to identify natural compounds with immunosuppressive activity, nine new flavonoids, including one isoflav-3-ene derivative (1), one coumaronochromone (2), two isoflavanones (3, 4), one isoflavone derivative (6), one isoflavone (7), three flavonols (8, 9, 10), as well as one known compound, hydroisoflavone C (5), were isolated from the roots of Campylotropis hirtella. The structures of these compounds were elucidated by extensive spectroscopic measurements. All of the compounds were assessed for immunosuppressive activity. Among the isolates, compound 2 showed good inhibitory activity against mitogen-induced splenocyte proliferation with an IC50 of 0.28 μM and relatively low cytotoxicity.
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; Suzhou Polytechnic Institute of Agriculture, Suzhou 215008, PR China.
Xiaoping
X
Li
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
Bixia
B
Xuan
Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, United States.
Qingyao
Q
Shou
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, PR China. Electronic address: jeff_shen_1999@yahoo.com.
Zhengwu
Z
Shen
D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008214:Lymphocytes / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal
D005419:Flavonoids; D007166:Immunosuppressive Agents; D010936:Plant Extracts
Campylotropis hirtella; Coumaronochromone; Flavonol; Immunosuppressive activity; Isoflavanone; Isoflavone