Controlled release of tinidazole and theophylline from chitosan based composite hydrogels.
Several composite hydrogels were synthesized by free radical crosslink copolymerization of acrylic acid (AA) and N' methylene bis-acrylamide (MBA) in the presence of chitosan (CS). During polymerization CS was incorporated in situ in the crosslinked polyacrylic acid gel to produce composite hydrogels. The structure and properties of the hydrogels were characterized by FTIR, (13)C NMR, DTA-TGA, XRD, swelling and diffusion characteristic and also network parameters. The loading and the in vitro release behaviours of theophylline and tinidazole model drugs were studied with these hydrogels. The wt% of CS and MBA and pH of the medium was found to strongly influence the drug release behaviour of the gels. Accordingly, the release rate of these two drugs was much faster at pH of 7.6 than at pH 1.5.
Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India.
Himadri Sekhar
HS
Samanta
Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India. Electronic address: samitcu2@yahoo.co.in.
Samit Kumar
SK
Ray
D000179:Acrylates / Q000737:chemistry*; D000477:Alkylating Agents / Q000008:administration & dosage / Q000737:chemistry; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D020100:Hydrogels / Q000008:administration & dosage* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013806:Theophylline / Q000008:administration & dosage* / Q000737:chemistry; D014011:Tinidazole / Q000008:administration & dosage* / Q000737:chemistry; D014961:X-Ray Diffraction
D000179:Acrylates; D000477:Alkylating Agents; D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D014011:Tinidazole; D048271:Chitosan; D013806:Theophylline; C036658:acrylic acid
Characterization; Chitosan; Composite hydrogels; Drug release; Polyacrylic acid; Synthesis