SysPTM 2.0: an updated systematic resource for post-translational modification.
Post-translational modifications (PTMs) of proteins play essential roles in almost all cellular processes, and are closely related to physiological activity and disease development of living organisms. The development of tandem mass spectrometry (MS/MS) has resulted in a rapid increase of PTMs identified on proteins from different species. The collection and systematic ordering of PTM data should provide invaluable information for understanding cellular processes and signaling pathways regulated by PTMs. For this original purpose we developed SysPTM, a systematic resource installed with comprehensive PTM data and a suite of web tools for annotation of PTMs in 2009. Four years later, there has been a significant advance with the generation of PTM data and, consequently, more sophisticated analysis requirements have to be met. Here we submit an updated version of SysPTM 2.0 (http://lifecenter.sgst.cn/SysPTM/), with almost doubled data content, enhanced web-based analysis tools of PTMBlast, PTMPathway, PTMPhylog, PTMCluster. Moreover, a new session SysPTM-H is constructed to graphically represent the combinatorial histone PTMs and dynamic regulation of histone modifying enzymes, and a new tool PTMGO is added for functional annotation and enrichment analysis. SysPTM 2.0 not only facilitates resourceful annotation of PTM sites but allows systematic investigation of PTM functions by the user. Database URL: http://lifecenter.sgst.cn/SysPTM/.
Key Laboratory of Biomedical Photonics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China, Shanghai Center for Bioinformation Technology, Shanghai Institutes of Biomedicine, Shanghai Academy of Science and Technology, Shanghai 201203, P. R. China, Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, P. R. China, Department of Bioinformatics and Biostatistics, Shanghai Jiaotong University, Shanghai 200240, P. R. China, Key Laboratory of Systems Biology, Chinese Academy of Sciences, Shanghai 200031, P. R. China and Proteome Center Rostock, Department for Proteome Research, Institute of Immunology, University of Rostock, Rostock 18055, Germany.
Jing
J
Li
Jia
J
Jia
Hong
H
Li
Jian
J
Yu
Han
H
Sun
Ying
Y
He
Daqing
D
Lv
Xiaojuan
X
Yang
Michael O
MO
Glocker
Liangxiao
L
Ma
Jiabei
J
Yang
Ling
L
Li
Wei
W
Li
Guoqing
G
Zhang
Qian
Q
Liu
Yixue
Y
Li
Lu
L
Xie
D000818:Animals; D030562:Databases, Protein; D006657:Histones / Q000378:metabolism; D006801:Humans; D011499:Protein Processing, Post-Translational; D012984:Software; D014584:User-Computer Interface; D064878:Web Browser
D006657:Histones