Pentraxin 3, long expression in mononuclear cells of patients with acute coronary syndrome: Correlation with C-reactive protein and matrix metalloproteinase-9 levels.
OBJECTIVE
To investigate expression of pentraxin 3, long (PTX3) in patients with acute coronary syndrome (ACS) and its correlation with matrix metalloproteinase-9 (MMP-9) and C-reactive protein (CRP) levels.


METHODS
Patients with ACS were randomly assigned to the ACS group (subdivided into unstable angina pectoris [UAP] and acute myocardial infarction [AMI]). Healthy participants and patients with stable angina pectoris (SAP) were enrolled as controls. Mononuclear cell PTX3 expression, and serum MMP-9 and CRP levels, were measured by enzyme-linked immunosorbent assay.


RESULTS
The ACS group comprised 200 patients (80 in the UAP subgroup; 120 in the AMI subgroup). The control group comprised 130 participants (80 healthy volunteers and 50 patients with SAP). PTX3 expression was significantly higher in the ACS group compared with controls (3.64 ± 0.49 versus 1.85 ± 0.65 ng/ml), and significantly higher in the AMI compared with the UAP subgroup (5.44 ± 0.47 versus 3.39 ± 0.59 ng/ml). Serum MMP-9 and CRP levels were significantly higher in the ACS group compared with controls (48.55 ± 14.22 versus 23.14 ± 0.62 ng/ml; 4.88 ± 1.76 versus 1.26 ± 0.19 ng/ml, respectively), and significantly higher in the AMI compared with the UAP subgroup (58.13 ± 7.24 versus 31.77 ± 3.61 ng/ml; 5.80 ± 1.46 versus 3.27 ± 0.83 ng/ml, respectively). PTX3 expression, and MMP-9 and CRP levels in the SAP subgroup, were not significantly different from the healthy participants. PTX3 expression positively correlated with MMP-9 and CRP levels.


CONCLUSIONS
In patients with ACS, peripheral blood mononuclear cell PTX3 expression, and serum MMP-9 and CRP levels, were significantly enhanced compared with controls; in addition, PTX3 expression positively correlated with MMP-9 and CRP levels. PTX3 may be involved in ACS pathogenesis.
Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan, China.
Ruilian
R
Ma
Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan, China.
Wei
W
Zhang
Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan, China.
Tiansong
T
Wang
Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan, China.
Ximin
X
He
The Hospital of the Chinese People's Armed Police Force Academy, Langfang, Hebei, China.
Zichong
Z
Huang
Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan, China.
Jinguo
J
Zhu
Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan, China yao.zhen@126.com.
Zhen
Z
Yao
D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D000368:Aged; D060050:Angina, Stable / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D000789:Angina, Unstable / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002097:C-Reactive Protein / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D011379:Prognosis; D000683:Serum Amyloid P-Component / Q000235:genetics* / Q000378:metabolism; D000099153:Pentraxins
D002097:C-Reactive Protein; D020780:Matrix Metalloproteinase 9; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
C-reactive protein; Pentraxin-related protein PTX3; acute coronary syndrome; matrix metalloproteinase-9; mononuclear cell