Tandem N-alkylation/vinylogous aldol reaction of β,γ-alkenyl α-iminoester.
This report describes a highly regioselective tandem N-alkylation/vinylogous aldol reaction of β,γ-alkenyl α-iminoesters. The sulfur group improves the regioselectivity of the directed vinylogous aldol reaction, providing a new synthetic method of 3-amino-2-pyrones.
Department of Chemistry for Materials, Graduate School of Engineering, Mie University , Tsu, Mie 514-8507, Japan.
Hirotaka
H
Tanaka
Isao
I
Mizota
Makoto
M
Shimizu