Trigonella foenum-graecum L. seed mucilage-gellan mucoadhesive beads for controlled release of metformin HCl.
Fenugreek (Trigonella foenum-graecum L.) seed mucilage (FSM)-gellan gum (GG) mucoadhesive beads containing metformin HCl for oral use were developed through ionotropic-gelation technique. Effects of GG to FSM ratio and cross-linker (CaCl2) concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release after 10h (R10h, %) of ionotropically-gelled FSM-GG mucoadhesive beads containing metformin HCl were optimized by 3(2) factorial design. The optimized mucoadhesive beads showed DEE of 92.53 ± 3.85% and R10h of 55.28 ± 1.58% and mean diameter of 1.62 ± 0.22 mm. The in vitro metformin HCl release from these ionotropically-gelled FSM-GG beads was prolonged over 10h and followed zero-order model with super case-II transport mechanism. The optimized mucoadhesive beads also exhibited pH-dependent swelling, good mucoadhesivity with biological mucosal membrane and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.
Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, Odisha, India.
Amit Kumar
AK
Nayak
Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur 495 009, C.G., India. Electronic address: drdilip2003@yahoo.co.in.
Dilipkumar
D
Pal
D000268:Adhesiveness; D000818:Animals; D002214:Capsules; D003692:Delayed-Action Preparations; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D008297:Male; D008687:Metformin / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D008863:Microspheres; D009092:Mucous Membrane / Q000737:chemistry*; D062087:Plant Mucilage / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D051381:Rats; D012639:Seeds / Q000737:chemistry*; D029910:Trigonella / Q000737:chemistry*
D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D062087:Plant Mucilage; D011135:Polysaccharides, Bacterial; C048288:gellan gum; D008687:Metformin
Controlled drug release; Fenugreek seed mucilage; Gellan gum; Metformin HCl; Mucoadhesion; Polymer-blend