Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes.
We have developed an automated photochemical microfluidics platform that integrates a 1 kW high-pressure Hg vapor lamp and allows for analytical pulse flow or preparative continuous flow reactions. Herein, we will discuss the use of this platform toward the discovery of new chemotypes through multidimensional reaction screening. We will highlight the ability to discretely control wavelengths with optical filters, allowing for control of reaction outcomes.
Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University , 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
Véronique I
VI
Martin
John R
JR
Goodell
Oscar J
OJ
Ingham
John A
JA
Porco
Aaron B
AB
Beeler
D044085:Microfluidics / Q000295:instrumentation; D008968:Molecular Conformation; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry*; D055668:Photochemical Processes
D009930:Organic Chemicals