Sarcoidosis associated with oxaliplatin-based chemotherapy for colorectal cancer.
Acute lung injury occasionally occurs after chemotherapy, but pulmonary toxicities by oxaliplatin-based chemotherapy have rarely been identified. A 76-year-old female with rectosigmoid colon cancer presented with ongoing dyspnea after the eighth cycle of standard chemotherapy (5-fluorouracil, sodium folinic acid, and oxaliplatin: FOLFOX). Nodular consolidation progressed despite antibiotics and BAL fluid analysis was compatible with the diagnosis of sarcoidosis. Corticosteroid therapy rapidly improved the symptoms and radiographic findings. We report this first case of secondary sarcoidosis related to FOLFOX therapy with review of references.
Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Daehwa-dong, Ilsanseo-gu, Goyang-si, Gyeonggi-do 2240, Republic of Korea.
Ji Hoon
JH
Choi
Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Daehwa-dong, Ilsanseo-gu, Goyang-si, Gyeonggi-do 2240, Republic of Korea.
Jung A
JA
Shin
Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Daehwa-dong, Ilsanseo-gu, Goyang-si, Gyeonggi-do 2240, Republic of Korea.
Hye Kyeong
HK
Park
Department of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Daehwa-dong, Ilsanseo-gu, Goyang-si, Gyeonggi-do 2240, Republic of Korea.
Su Young
SY
Kim
Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Daehwa-dong, Ilsanseo-gu, Goyang-si, Gyeonggi-do 2240, Republic of Korea.
Hoon
H
Jung
Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Daehwa-dong, Ilsanseo-gu, Goyang-si, Gyeonggi-do 2240, Republic of Korea.
Sung-Soon
0000-0001-6422-2313
SS
Lee
Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Daehwa-dong, Ilsanseo-gu, Goyang-si, Gyeonggi-do 2240, Republic of Korea.
Hye Ran
HR
Lee
Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Daehwa-dong, Ilsanseo-gu, Goyang-si, Gyeonggi-do 2240, Republic of Korea.
Hyeon-Kyoung
0000-0002-1200-9892
HK
Koo