Therapeutical potential of CB₂ receptors in immune-related diseases.
The cannabinoid receptor CB2 is highly expressed in immune cells suggesting an important role in numerous diseases such as inflammation, cancer, osteoporosis and liver diseases relating to modulation of the immune system. As a consequence, activation of receptor CB2 is a promising therapeutic strategy for the treatment of a large range of diseases. Indeed, selective CB2 agonists display beneficial anti-inflammatory, anti-cancer and antifibrogenic properties and positive effects on liver disease and osteoporosis. This article reviews the CB2 involvement in the immune system and the promising therapeutical potential of selective CB2 agonists in the treatment of several immune-related diseases.
Natascha
N
Leleu-Chavain
Pierre
P
Desreumaux
Philippe
P
Chavatte
Universite du Droit et de la Sante de Lille, EA 4481, Institut de Chimie Pharmaceutique Albert Lespagnol, 3 rue du Pr. Laguesse, B.P. 83, F-59006 Lille, France. regis.millet@univ-lille2.fr.
Régis
R
Millet
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D055808:Drug Discovery; D006801:Humans; D007107:Immune System / Q000187:drug effects* / Q000276:immunology; D008107:Liver Diseases / Q000188:drug therapy / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology; D010024:Osteoporosis / Q000188:drug therapy / Q000276:immunology; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists* / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D043885:Receptor, Cannabinoid, CB2