2013 new drug update: what do new approvals hold for the elderly?
Six new drugs that are used for medical problems often experienced by the elderly have been selected for consideration in this review. The uses and most important properties of these agents are reviewed, and a rating for each new drug is determined. The rating is based on a comparison of the new drug with related drugs already marketed. Advantages, disadvantages, and other important information regarding the new drug are identified and used as the basis for determining the rating.
Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania.
Daniel A
DA
Hussar
D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001067:Appetite Depressants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D017277:Drug Approval; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D014481:United States
D000925:Anticoagulants; D018501:Antirheumatic Agents; D001067:Appetite Depressants; D001993:Bronchodilator Agents; D007004:Hypoglycemic Agents
ACEI = Angiotensin-converting enzyme inhibitor; ARB = Angiotensin receptor blocker; Alogliptin; Anorexiant; Antiarthritic agent; Anticoagulant; Apixaban; Atrial fibrillation; BMI = Body mass index; Bronchodilator; COPD = Chronic obstructive pulmonary disease; CYP = Cytochrome P450; Canagliflozin; DMARD = Disease-modifying antirheumatic drug; DPP-4 = Dipeptidyl peptidase 4; DVT = Deep vein thrombosis; Diabetes; Elderly; FDA = Food and Drug Administration; Fluticasone; HbA1C = Hemoglobin A1C; INR = International normalized ratio; JAK = Janus kinases; LABA = Long-acting beta2-adrenergic receptor agonist; Lorcaserin; MDRD = Modification of diet in renal disease; MI = Myocardial infarction; NDCR = New Drug Comparison Rating; P-gp = P-glycoprotein; PE = Pulmonary embolism; Phentermine; SGLT2 = Sodium-glucose co-transporter 2; SNRI = Serotonin norepinephrine reuptake inhibitor; T2DM = Type 2 diabetes mellitus; TNF = Tumor necrosis factor; Tofacitinib; Topiramate; UGT = Uridine diphosphate glucuronosyl transferase; Vilanterol; eGFR = Estimated glomerular filtration rate