Infectious pathogens and bronchiolitis outcomes.
Bronchiolitis is a common early childhood illness and an important cause of morbidity, it is the number one cause of hospitalization among US infants. Bronchiolitis is also an active area of research, and recent studies have advanced our understanding of this illness. Although it has long been the conventional wisdom that the infectious etiology of bronchiolitis does not affect outcomes, a growing number of studies have linked specific pathogens of bronchiolitis (e.g., rhinovirus) to short- and long-term outcomes, such as future risk of developing asthma. The authors review the advent of molecular diagnostic techniques that have demonstrated diverse pathogens in bronchiolitis, and they review recent studies on the complex link between infectious pathogens of bronchiolitis and the development of childhood asthma.
Department of Emergency Medicine (KH, CAC), Boston, MA, USA.
Kohei
K
Hasegawa
Jonathan M
JM
Mansbach
Carlos A
CA
Camargo
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001249:Asthma / Q000209:etiology; D001988:Bronchiolitis / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D007223:Infant; D010850:Picornaviridae Infections / Q000150:complications / Q000188:drug therapy; D012135:Respiratory Sounds; D018357:Respiratory Syncytial Virus Infections / Q000150:complications / Q000188:drug therapy; D012307:Risk Factors
D000305:Adrenal Cortex Hormones
IgE; acute respiratory infection; asthma; atopy; bronchiolitis; recurrent wheeze; respiratory syncytial virus; rhinovirus