Synthesis, spectral characterization, and antiproliferative studies of mixed ligand titanium complexes of adamantylamine.
Titanium complexes have been synthesized by the reaction between titanium tetrachloride (TiCl4), respective bidentate ligand [4,4' -dimethoxy-2,2' -bipyridine (bpome), 6,6'-dimethyl-2,2'-bipyridine (dpme), 1,2-diaminocyclohexane (dach), 1,10-phenanthroline (phen), and benzoylacetone (bzac)], and adamantylamine (ada) in 1 : 2 : 2 molar ratios, respectively. The structure of synthesized complexes was confirmed using elemental analysis, FTIR, UV-visible, (1)H NMR, and mass spectrometry techniques. The nanocrystalline nature of complexes was confirmed by powder XRD study. The complexes were evaluated for cytotoxic potential in HeLa (cervical), C6 (glioma), and CHO (Chinese hamster ovarian) cell lines. The complex E was found to be more effective cytotoxic agent against HeLa cell line with an IC50 value of 4.06 µM. Furthermore, the effect of synthesized complexes was studied on different stages of the cell cycle in CHO cells. All complexes exhibited the dose dependent increase in cytotoxicity. The results have shown an increase in sub-G0 population with increase in concentration which is an indicative measure of apoptosis.
Department of Chemistry, National Institute of Technology, Hamirpur, Himachal Pradesh 177005, India.
Raj
0000-0003-0198-581X
R
Kaushal
Department of Chemistry, National Institute of Technology, Hamirpur, Himachal Pradesh 177005, India.
Nitesh
0000-0002-1301-831X
N
Kumar
Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India.
Ashun
A
Chaudhary
Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India.
Saroj
S
Arora
Department of Chemistry, National Institute of Technology, Hamirpur, Himachal Pradesh 177005, India.
Pamita
P
Awasthi