Surface-based regional homogeneity in first-episode, drug-naïve major depression: a resting-state FMRI study.
BACKGROUND
Previous volume-based regional homogeneity (ReHo) studies neglected the intersubject variability in cortical folding patterns. Recently, surface-based ReHo was developed to reduce the intersubject variability and to increase statistical power. The present study used this novel surface-based ReHo approach to explore the brain functional activity differences between first-episode, drug-naïve MDD patients and healthy controls.


METHODS
Thirty-three first-episode, drug-naïve MDD patients and 32 healthy controls participated in structural and resting-state fMRI scans. MDD patients were rated with a 17-item Hamilton Rating Scale for Depression prior to the scan.


RESULTS
In comparison with the healthy controls, MDD patients showed reduced surface-based ReHo in the left insula. There was no increase in surface-based ReHo in MDD patients. The surface-based ReHo value in the left insula was not significantly correlated with the clinical information or the depressive scores in the MDD group.


CONCLUSIONS
The decreased surface-based ReHo in the left insula in MDD may lead to the abnormal top-down cortical-limbic regulation of emotional and cognitive information. The surface-based ReHo may be a useful index to explore the pathophysiological mechanism of MDD.
Laboratory for Functional Connectome and Development, Magnetic Resonance Imaging Research Center, Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China.
Hui-Jie
HJ
Li
Department of Psychiatry, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan 030001, China.
Xiao-Hua
XH
Cao
Laboratory for Functional Connectome and Development, Magnetic Resonance Imaging Research Center, Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China ; University of Chinese Academy of Sciences, Beijing 100049, China.
Xing-Ting
0000-0003-2121-8634
XT
Zhu
Department of Psychiatry, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan 030001, China.
Ai-Xia
AX
Zhang
Laboratory for Functional Connectome and Development, Magnetic Resonance Imaging Research Center, Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China ; University of Chinese Academy of Sciences, Beijing 100049, China.
Xiao-Hui
XH
Hou
Department of Psychiatry, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan 030001, China.
Yong
Y
Xu
Laboratory for Functional Connectome and Development, Magnetic Resonance Imaging Research Center, Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China.
Xi-Nian
XN
Zuo
Department of Psychiatry, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan 030001, China.
Ke-Rang
KR
Zhang
D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013499:Surface Properties