Progressive multifocal cerebral infarction in a young kidney transplant recipient due to thrombotic microangiopathy.
BACKGROUND
Renal transplant recipients frequently experience neurological complications. Whereas ischemic stroke, cerebral haemorrhage or hypertensive encephalopathy often result from vascular alterations prior to transplantation, other cerebral diseases like CNS infections, primary brain tumors and drug induced neurotoxicity may develop as consequences of the required post-transplant immunosuppressive treatment.


METHODS
Here we report on an unusual clinical course of a young kidney transplant recipient with a cluster of fulminant necrotic brain lesions within a period of two months due to thrombotic microangiopathy.


CONCLUSIONS
Cerebral ischemia in organ transplant recipients should prompt one to consider thrombotic microangiopathy.
Center of Internal Medicine, Hannover Medical School, Hannover, Germany. haghikia.arash@mh-hannover.de.
Arash
A
Haghikia
Meike
M
Heeren
Clemens
C
Bockmeyer
Bernd
B
Haubitz
Wilfried
W
Gwinner
D000328:Adult; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D020767:Intracranial Thrombosis / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D057049:Thrombotic Microangiopathies / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control