A switchable peptide sensor for real-time lysosomal tracking.
A bis-spiropyran functionalized peptide 1, which exhibits good cell-permeability, excellent biocompatibility and low cytotoxicity, has been developed for reversible and real-time lysosomal tracking.
Key Labs for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China. jcwu@ecust.edu.cn tianhe@ecust.edu.cn.
Lei
L
Chen
Junchen
J
Wu
Carsten
C
Schmuck
He
H
Tian
D001578:Benzopyrans / Q000737:chemistry*; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry*; D008247:Lysosomes / Q000737:chemistry / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D009574:Nitro Compounds / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D059008:Time-Lapse Imaging; D014466:Ultraviolet Rays
D001578:Benzopyrans; D005456:Fluorescent Dyes; D007211:Indoles; D009574:Nitro Compounds; D010455:Peptides; C088184:spiropyran