Severe lactic acidosis in a diabetic patient after ethanol abuse and floor cleaner intake.
An intoxication with drugs, ethanol or cleaning solvents may cause a complex clinical scenario if multiple agents have been ingested simultaneously. The situation can become even more complex in patients with (multiple) co-morbidities. A 59-year-old man with type 2 diabetes mellitus (without treatment two weeks before the intoxication) intentionally ingested a substantial amount of ethanol along with ~750 mL of laminate floor cleaner containing citric acid. The patient was admitted with severe metabolic acidosis (both ketoacidosis and lactic acidosis, with serum lactate levels of 22 mM). He was treated with sodium bicarbonate, insulin and thiamine after which he recovered within two days. Diabetic ketoacidosis and lactic acidosis aggravated due to ethanol intoxication, thiamine deficiency and citrate. The high lactate levels were explained by excessive lactate formation caused by the combination of untreated diabetes mellitus, thiamine deficiency and ethanol abuse. Metabolic acidosis in diabetes is multi-factorial, and the clinical situation may be further complicated, when ingestion of ethanol and toxic agents are involved. Here, we reported a patient in whom diabetic ketoacidosis was accompanied by severe lactic acidosis as a result of citric acid and mainly ethanol ingestion and a possible thiamine deficiency. In the presence of lactic acidosis in diabetic ketoacidosis, physicians need to consider thiamine deficiency and ingestion of ethanol or other toxins.
Department of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands.
Jeroen J M A
JJ
Hendrikx
Jurjen S
JS
Lagas
Ratana
R
Daling
Jan Hendrik
JH
Hooijberg
Jan H M
JH
Schellens
Jos H
JH
Beijnen
Desiderius P M
DP
Brandjes
Alwin D R
AD
Huitema
D000138:Acidosis / Q000139:chemically induced* / Q000188:drug therapy; D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000188:drug therapy; D000435:Alcoholic Intoxication / Q000150:complications*; D019343:Citric Acid / Q000506:poisoning*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D017693:Sodium Bicarbonate / Q000627:therapeutic use; D013831:Thiamine / Q000627:therapeutic use; D013832:Thiamine Deficiency / Q000150:complications
D007328:Insulin; D019343:Citric Acid; D017693:Sodium Bicarbonate; D013831:Thiamine