Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma.
About 61-72% of transcribed regions possess long noncoding RNAs in antisense orientation (Antisense long noncoding RNAs, aslncRNAs). However, the function of aslncRNAs in HCC remains unclear. We found numerous aslncRNAs were deregulated and might be involved in regulatory gene-net of HCC. The PCNA-AS1, antisense to PCNA, is significantly up-regulated in HCC and could promote tumor growth in vitro and in vivo. The effects of PCNA-AS1 rely on regulation of PCNA via forming RNA hybridization to increase PCNA mRNA stability. We concluded that aslncRNAs might act as upstream regulators in HCC and PCNA-AS1 could serve as a novel therapeutic target.
The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: yuanshengx@126.com.
Sheng-Xian
SX
Yuan
The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: tqftxl@163.com.
Qi-Fei
QF
Tao
Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. Electronic address: msswjw@163.com.
Jie
J
Wang
Department of Medical Genetics, Second Military Medical University, Shanghai, China. Electronic address: yangfusq1997@hotmail.com.
Fu
F
Yang
Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. Electronic address: leiliu@sibs.ac.cn.
Lei
L
Liu
The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: 362769189@qq.com.
Li-Li
LL
Wang
The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: Zhangjin_sh@126.com.
Jin
J
Zhang
The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: yangyuan.ehbh@gmail.com.
Yuan
Y
Yang
The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: liuhuigg@hotmail.com.
Hui
H
Liu
Department of Medical Genetics, Second Military Medical University, Shanghai, China. Electronic address: wfsjz70@gmail.com.
Fang
F
Wang
Department of Medical Genetics, Second Military Medical University, Shanghai, China. Electronic address: shsun@vip.sina.com.
Shu-Han
SH
Sun
The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: ehphwp3@126.com.
Wei-Ping
WP
Zhou
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics*; D016372:RNA, Antisense / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D015854:Up-Regulation
D018809:Proliferating Cell Nuclear Antigen; D016372:RNA, Antisense; D062085:RNA, Long Noncoding; D012333:RNA, Messenger
Antisense RNA; Long noncoding RNA; RNA hybridazation; RNA stability; Tumor growth