Effect of endogenous sulfur dioxide in regulating cardiovascular oxidative stress.
In the middle of the 1980s, nitric oxide received extensive attention because of its significant effects in life science. Then, carbon monoxide and hydrogen sulfide were discovered to be gasotransmitters playing important roles in regulating cellular homeostasis. As a common air pollutant, sulfur dioxide (SO₂) can cause great harm to the human body by producing free radicals, which causes oxidative damage to various organs. Recently, endogenous SO2 was found to be produced in the cardiovascular system and might be a bioactive molecule regulating the physiological activities including cardiovascular oxidative stress.
Department of Pediatrics, Peking University First Hospital, Beijing, PR China.
Mingzhu
M
Zhu
Department of Pediatrics, Peking University First Hospital, and Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing, PR China.
Junbao
J
Du
Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Angie Dong
AD
Liu
Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Lukas
L
Holmberg
Key Laboratory of Molecular Cardiology, Ministry of Education, and Department of Physiology and Pathophysiology, Health Sciences Center, Peking University, PR China.
Chaoshu
C
Tang
Department of Pediatrics, Peking University First Hospital, Beijing, PR China. jinhongfang51@126.com.
Hongfang
H
Jin
D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D013458:Sulfur Dioxide / Q000378:metabolism*
D016877:Oxidants; D013458:Sulfur Dioxide