A clinical and pathological overview of vulvar condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma.
Condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma are three relatively frequent vulvar lesions. Condyloma acuminatum is induced by low risk genotypes of human papillomavirus (HPV). Vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma have different etiopathogenic pathways and are related or not with high risk HPV types. The goal of this paper is to review the main pathological and clinical features of these lesions. A special attention has been paid also to epidemiological data, pathological classification, and clinical implications of these diseases.
Department of Pathology, University Hospital of Liège, 4000 Liège, Belgium.
Boris
B
Léonard
Department of Gynecology, University Hospital of Liège, 4000 Liège, Belgium.
Frederic
F
Kridelka
Department of Pathology, University Hospital of Liège, 4000 Liège, Belgium.
Katty
K
Delbecque
Department of Gynecology, University Hospital of Liège, 4000 Liège, Belgium.
Frederic
F
Goffin
Laboratory of Experimental Pathology, GIGA-Cancer, University of Liège, 4000 Liège, Belgium.
Stéphanie
S
Demoulin
Department of Gynecology, University Hospital of Liège, 4000 Liège, Belgium.
Jean
J
Doyen
Department of Pathology, University Hospital of Liège, 4000 Liège, Belgium.
Philippe
P
Delvenne
D002278:Carcinoma in Situ / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003218:Condylomata Acuminata / Q000473:pathology*; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology / Q000821:virology; D011230:Precancerous Conditions / Q000473:pathology / Q000821:virology; D014846:Vulvar Neoplasms / Q000150:complications / Q000473:pathology*