Journey to the center of the centrosome.
Little is understood about how the centrosome, a complex organelle and signaling hub consisting of hundreds of components, is assembled. In this issue of Developmental Cell, Conduit et al. (2014) shed light on this issue, showing that modification and recruitment of Centrosomin to the centrosome center creates a dynamic pericentriolar matrix.
Department of Biology, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: stearns@stanford.edu.
Tim
T
Stearns
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D018385:Centrosome / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000378:metabolism*; D008938:Mitosis / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D000097869:Polo-Like Kinase 1
D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1; C098130:cnn protein, Drosophila; C072004:polo protein, Drosophila