[Significance of SAMD9 expression in esophageal squamous cell carcinoma].
OBJECTIVE
To analyze the significance of sterile alpha motif domain-containing 9 (SAMD9) expression in esophageal squamous cell carcinoma (ESCC).


METHODS
Immunohistochemical staining was performed to detect the expression of SAMD9 in 72 primary ESCC and matched adjacent cancer-free tissues and analyze the significance of SAMD9 expression in ESCC tissues. In addition, Western blotting was used to detect the expression of SAMD9 in primary ESCC tissues which were taken from 3 metastatic and 3 non-metastatic patients during surgery.


RESULTS
The expression of SAMD9 in the ESCC tissues had no statistical difference from that in the matched adjacent cancer-free tissues. SAMD9 expression was significantly correlated with lymphatic invasion and metastasis in these patients (P<0.05), but not with age, gender, tumor differentiation and T stage (P>0.05). Western blotting showed that SAMD9 expression in primary ESCC tissues was significantly higher in the patients with metastasis than in the ones without metastasis(P<0.01).


CONCLUSIONS
Over-expression of SAMD9 is correlated with the metastasis of ESCC, indicating that it might play an important role in the metastasis of ESCC.
Department of Digestion, General Hospital of Chengdu Military Command, Chengdu 610000, China.
Shanhong
S
Tang
Department of Thoracic Surgery, General Hospital of Chengdu Military Command, Chengdu 610000, China.
Xiushan
X
Zheng
Department of Digestion, General Hospital of Chengdu Military Command, Chengdu 610000, China.
Li
L
He
Department of Digestion, General Hospital of Chengdu Military Command, Chengdu 610000, China.
Lijuan
L
Qiao
Department of Digestion, General Hospital of Chengdu Military Command, Chengdu 610000, China.
Dan
D
Jing
Department of Digestion, General Hospital of Chengdu Military Command, Chengdu 610000, China.
Zhen
Z
Ni
Department of Digestion, General Hospital of Chengdu Military Command, Chengdu 610000, China.
Weizheng
W
Zeng
Department of Digestion, General Hospital of Chengdu Military Command, Chengdu 610000, China.
Mingde
M
Jiang
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011506:Proteins / Q000378:metabolism*
D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; C514443:SAMD9 protein, human