Visit-to-visit variability of blood pressure and renal function decline in patients with diabetic chronic kidney disease.
The authors previously reported that the visit-to-visit variability of blood pressure is correlated with renal function decline in nondiabetic chronic kidney disease. Little is known about the association between visit-to-visit variability and renal function decline in patients with diabetic chronic kidney disease. The authors retrospectively studied 69 patients with diabetic chronic kidney disease stage 3a, 3b, or 4. The standard deviation and coefficient of variation of blood pressure in 12 consecutive visits were defined as visit-to-visit variability of blood pressure. The median observation period was 32 months. In univariate correlation, the standard deviation and coefficient of variation of blood pressure were not significantly associated with the slope of estimated glomerular filtration rate. There was no significant association between the visit-to-visit variability of blood pressure and renal function decline in patients with diabetic chronic kidney disease, in contrast with our previous study of nondiabetic patients with chronic kidney disease.
Division of Cardiovascular Medicine, Department of Medicine, School of Medicine, Jichi Medical University, Tochigi, Japan; Department of Nephrology, Iwakuni Medical Center, Yamaguchi, Japan; Department of Nephrology and Hypertension, School of Medicine, St. Marianna University, Kanagawa, Japan.
Kei
K
Yokota
Masamichi
M
Fukuda
Yoshio
Y
Matsui
Kazuomi
K
Kario
Kenjiro
K
Kimura
D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D002908:Chronic Disease; D003928:Diabetic Nephropathies / Q000150:complications / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D009819:Office Visits; D011379:Prognosis; D012189:Retrospective Studies