Association between cyclooxygenase-2 gene polymorphisms and risk of periodontitis: a meta-analysis involving 5653 individuals.
There -765G > C, -1195G > A, and 8473T > C polymorphisms in cyclooxygenase-2 (COX-2) gene polymorphisms and periodontitis risk were investigated based on published studies; however, their results could not give a conclusive result. Hence, we performed this meta-analysis of six published studies with eight case-control studies including these three polymorphisms which searched from PubMed and Web of Science up to October 15th, 2013. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the association between the three polymorphisms of COX-2 and periodontitis risk. The results from 2,580 periodontitis patients and 3,073 healthy controls showed that none of -765G > C, -1195G > A, or 8473T > C polymorphism was not associated with periodontitis susceptibility [Take -765G > C for example: OR = 0.94, 95% CI = (0.57-1.53) for C vs. G; OR = 2.34, 95% CI = (0.72-7.62) for CC vs. GG; OR = 0.68, 95% CI = (0.46-1.01) for CG vs. GG; OR = 0.81, 95% CI = (0.52-1.27) for (CG+GG) vs. GG; OR = 2.57, 95% CI = (0.80-8.29) for CC vs. (GG+CG)]. In subgroup analyses according to the type of periodontitis and ethnicity for -765G > C and -1195G > A, and deviations in Hardy-Weinberg equilibrium for -765G > C, we only observe a boundary association between -1195G > A polymorphism and Asian population. However, due to limitations of this meta-analysis, the results should treat with caution and we suggest the further researches should be carried out to verify our results.
Department of Stomatology, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People's Republic of China.
Ling
L
Jiang
Hong
H
Weng
Ming-Yue
MY
Chen
Chao
C
Zhang
Xian-Tao
XT
Zeng
D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D010518:Periodontitis / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D044465:White People
D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human