Spontaneous Dissociation of Fluocinolone Acetonide Sustained Release Implant (Retisert) with Dislocation into the Anterior Chamber.
OBJECTIVE
To report two cases of spontaneous Retisert implant dissociation with dislocation of the medication reservoir into the anterior chamber.


METHODS
Case reports.


RESULTS
Two patients with chronic, noninfectious uveitis following Retisert implantation between 6 and 7 years prior presented with a complaint of a "white spot" in their right eyes. Both patients had previous pars plana vitrectomies. Anterior segment examination revealed a dislocated medication reservoir of the Retisert implant in the inferior portion of anterior chamber with associated reservoir-corneal endothelial touch and stromal edema. The reservoirs were subsequently retrieved via a pars plana approach and removed from the anterior chamber through a corneal incision.


CONCLUSIONS
Spontaneous dissociation of the Retisert implant with dislocation of the medication reservoir into the anterior chamber can be a late complication of Retisert implantation. Eye care professionals and patients should be aware of this complication, particularly with long-term intraocular retention of this device.
a Department of Ophthalmology , The New York Eye & Ear Infirmary of Mt. Sinai , New York , USA .|b Icahn School of Medicine at Mount Sinai , New York , NY , USA , and.
Peter Y
PY
Chang
a Department of Ophthalmology , The New York Eye & Ear Infirmary of Mt. Sinai , New York , USA .|b Icahn School of Medicine at Mount Sinai , New York , NY , USA , and.
Zvi
Z
Kresch
a Department of Ophthalmology , The New York Eye & Ear Infirmary of Mt. Sinai , New York , USA .|b Icahn School of Medicine at Mount Sinai , New York , NY , USA , and.
C Michael
CM
Samson
a Department of Ophthalmology , The New York Eye & Ear Infirmary of Mt. Sinai , New York , USA .|b Icahn School of Medicine at Mount Sinai , New York , NY , USA , and.|c Department of Ophthalmology , Winthrop University Hospital , Mineola , New York , USA.
Ronald C
RC
Gentile
D000328:Adult; D000867:Anterior Chamber; D003692:Delayed-Action Preparations; D004343:Drug Implants / Q000009:adverse effects; D005260:Female; D005446:Fluocinolone Acetonide / Q000008:administration & dosage* / Q000009:adverse effects; D005548:Foreign-Body Migration / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D015866:Uveitis, Posterior / Q000188:drug therapy*; D014821:Vitrectomy; D014822:Vitreous Body
D003692:Delayed-Action Preparations; D004343:Drug Implants; D005938:Glucocorticoids; D005446:Fluocinolone Acetonide
Anterior chamber; Retisert; dislocation; dissociation; fluocinolone acetonide; implant; separation; spontaneous; uveitis