Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities.
We investigated the relative biological effectiveness (RBE) of therapeutic proton beams at six proton facilities in Japan with respect to cell lethality of HSG cells. The RBE of treatments could be determined from experimental data. For this purpose, we used a cell survival assay to compare the cell-killing efficiency of proton beams. Among the five linear accelerator (LINAC) X-ray machines at 4 or 6 MeV that were used as reference beams, there was only a small variation (coefficient of variation CV = 3.1% at D10) in biological effectiveness. The averaged value of D10 for the proton beams at the middle position of the spread-out Bragg peak (SOBP) was 4.98. These values showed good agreement, with a CV of 4.3% among the facilities. Thus, the average RBE10 (RBE at the D10 level) at the middle position of the SOBP beam for six facilities in Japan was 1.05 with a CV of 2.8%.
Research Center for Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
Mizuho
M
Aoki-Nakano
Research Center for Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan furusawa@nirs.go.jp.
Yoshiya
Y
Furusawa
Research Center for Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
Akiko
A
Uzawa
Research Center for Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
Yoshitaka
Y
Matsumoto
Research Center for Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
Ryoichi
R
Hirayama
Research Center for Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
Chizuru
C
Tsuruoka
National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.
Takashi
T
Ogino
National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.
Teiji
T
Nishio
Hyogo Ion Beam Medical Center, 1-2-1 Koto, Shingu-cho, Tatsuno-shi, Hyogo 679-5165, Japan.
Kazufumi
K
Kagawa
Hyogo Ion Beam Medical Center, 1-2-1 Koto, Shingu-cho, Tatsuno-shi, Hyogo 679-5165, Japan.
Masao
M
Murakami
Wakasa Wan Energy Research Center, 64-52-1 Nagatani, Tsuruga, Fukui 914-0192, Japan.
Go
G
Kagiya
Wakasa Wan Energy Research Center, 64-52-1 Nagatani, Tsuruga, Fukui 914-0192, Japan.
Kyo
K
Kume
Wakasa Wan Energy Research Center, 64-52-1 Nagatani, Tsuruga, Fukui 914-0192, Japan.
Masanori
M
Hatashita
Wakasa Wan Energy Research Center, 64-52-1 Nagatani, Tsuruga, Fukui 914-0192, JapanResearch Center for Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
Shigekazu
S
Fukuda
Wakasa Wan Energy Research Center, 64-52-1 Nagatani, Tsuruga, Fukui 914-0192, Japan Proton Therapy Center, Fukui Prefectural Hospital, 2-8-1, Yotsui, Fukui 910-8526, Japan.
Kazutaka
K
Yamamoto
Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan.
Hiroshi
H
Fuji
Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan.
Shigeyuki
S
Murayama
Proton Medical Research Center, University of Tsukuba, 2-1-1 Amakubo, Tsukuba, Ibaraki 365-8576, Japan.
Masaharu
M
Hata
Proton Medical Research Center, University of Tsukuba, 2-1-1 Amakubo, Tsukuba, Ibaraki 365-8576, Japan.
Takeji
T
Sakae
University of Fukui, 23-3 Matsuoka-shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
Hideki
H
Matsumoto
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000528:radiation effects; D006801:Humans; D007564:Japan; D061766:Proton Therapy; D012062:Relative Biological Effectiveness; D012468:Salivary Gland Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D014410:Tumor Stem Cell Assay
cell survival; proton therapy; relative biological effectiveness; spread-out Bragg-peak