HELLP syndrome preceded by intrahepatic cholestasis of pregnancy: one serious itch.
We present four women with seven ongoing pregnancies. Five pregnancies were complicated by intrahepatic cholestasis of pregnancy (ICP) and severe haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome with uncommon maternal morbidity. The combination of ICP and HELLP syndrome has not previously been reported. Awareness is warranted to accurately identify this combination of pregnancy-specific diseases with severe maternal morbidity.
Women's and Children's Clinic, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Jiska
J
Jebbink
Merit
M
Tabbers
Gijs
G
Afink
Ulrich
U
Beuers
Ronald Oude
RO
Elferink
Carrie
C
Ris-Stalpers
Joris
J
van der Post
D000328:Adult; D002780:Cholestasis, Intrahepatic / Q000150:complications / Q000175:diagnosis*; D005260:Female; D017359:HELLP Syndrome / Q000175:diagnosis*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011537:Pruritus / Q000175:diagnosis* / Q000209:etiology