Increased steroid receptor RNA activator protein (SRAP) accompanied by decreased estrogen receptor-beta (ER-β) levels during the malignant transformation of endometriosis associated ovarian clear cell carcinoma.
The modulating attributes of steroid receptor RNA activator protein (SRAP) on steroid receptors have been shown in some types of tumor cells. There is compelling evidence to suggest that this molecule may play a critical role in the development of the tumor. However, little has been reported on its expression in endometriosis associated ovarian clear cell carcinoma (EAOCCC). In order to investigate the role of SRAP and estrogen receptors (ERs) in EAOCCC, we have analyzed the distribution of these proteins in the malignant transformation tissues and endometrioma tissues by immunohistochemistry. Our results revealed that the positive ratio of ER-β expression was gradually reduced during the malignant transformation from endometriosis to atypical endometriosis to clear cell carcinoma. Conversely, during the process, a gradual increase in SRAP expression was observed. Furthermore, there is a negative relationship between the expressions of these two molecules. Overall an increase in SRAP and a reduction in ER-β expression might be associated with malignant transformation of EAOCCC.
Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, Zhejiang 310006, People's Republic of China.
Kaiqing
K
Lin
Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, Zhejiang 310006, People's Republic of China.
Hong
H
Zhan
Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, Zhejiang 310006, People's Republic of China.
Junyan
J
Ma
Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, Zhejiang 310006, People's Republic of China.
Kaihong
K
Xu
Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, Zhejiang 310006, People's Republic of China.
Ruijin
R
Wu
Department of Pathology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, Zhejiang 310006, People's Republic of China.
Caiyun
C
Zhou
Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, Zhejiang 310006, People's Republic of China. Electronic address: linjun1088@163.com.
Jun
J
Lin
D018262:Adenocarcinoma, Clear Cell / Q000150:complications* / Q000503:physiopathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D004715:Endometriosis / Q000150:complications*; D047629:Estrogen Receptor beta / Q000235:genetics / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000150:complications* / Q000503:physiopathology; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism
D047629:Estrogen Receptor beta; D062085:RNA, Long Noncoding; C405423:steroid receptor RNA activator
ER-β; Endometriosis; Malignant transformation; Ovarian clear cell carcinoma; SRAP