Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds.
A virus-activated matrix is developed to overcome the challenge of forming vascularized bone tissue. It is generated by filling a 3D printed bioceramic scaffold with phage nanofibers displaying high-density RGD peptide. After it is seeded with mesenchymal stem cells (MSCs) and implanted into a bone defect, the phage nanofibers induce osteogenesis and angiogenesis by activating endothelialization and osteogenic differentiation of MSCs.
Department of Chemistry and Biochemistry, University of Oklahoma, Stephenson Life Sciences Research Center, Norman, OK 73019, USA.
Jianglin
J
Wang
Institute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Yuhangtang Road 866, Hangzhou, Zhejiang 310058, China.
Mingying
M
Yang
Department of Chemistry and Biochemistry, University of Oklahoma, Stephenson Life Sciences Research Center, Norman, OK 73019, USA.
Ye
Y
Zhu
Department of Chemistry and Biochemistry, University of Oklahoma, Stephenson Life Sciences Research Center, Norman, OK 73019, USA.
Lin
L
Wang
Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Antoni P
AP
Tomsia
Department of Chemistry and Biochemistry, University of Oklahoma, Stephenson Life Sciences Research Center, Norman, OK 73019, USA.
Chuanbin
C
Mao
D001435:Bacteriophages / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D001842:Bone and Bones / Q000098:blood supply / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D059630:Mesenchymal Stem Cells / Q000187:drug effects; D057139:Nanofibers; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D009842:Oligopeptides / Q000737:chemistry; D010012:Osteogenesis / Q000187:drug effects*; D066330:Printing, Three-Dimensional; D054457:Tissue Scaffolds / Q000737:chemistry
D001672:Biocompatible Materials; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid
3D printing; bone regeneration; nanofibers; phage display; scaffolds