Sevoflurane postconditioning provides neuroprotection against brain hypoxia-ischemia in neonatal rats.
Application of volatile anesthetics after brain ischemia provides neuroprotection in adult animals (anesthetic postconditioning). We tested whether postconditioning with sevoflurane, the most commonly used general anesthetic in pediatric anesthesia, reduced neonatal brain injury in rats. Seven-day-old Sprague-Dawley rats were subjected to brain hypoxia-ischemia (HI). They were postconditioned with sevoflurane in the presence or absence of 5-hydroxydecanoic acid, a mitochondrial KATP channel inhibitor. Sevoflurane postconditioning dose-dependently reduced brain tissue loss observed 7 days after brain HI. This effect was induced by clinically relevant concentrations and abolished by 5-hydroxydecanoic acid. These results suggest that sevoflurane postconditioning protects neonatal brain against brain HI via mitochondrial KATP channels.
Department of Anesthesiology, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Xiaoyan
X
Ren
Zhi
Z
Wang
Hong
H
Ma
Zhiyi
Z
Zuo
D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D003652:Decanoic Acids / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006880:Hydroxy Acids / Q000494:pharmacology; D020925:Hypoxia-Ischemia, Brain / Q000517:prevention & control*; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D026902:Potassium Channel Blockers / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077149:Sevoflurane
D003652:Decanoic Acids; D006880:Hydroxy Acids; D008738:Methyl Ethers; D018696:Neuroprotective Agents; D026902:Potassium Channel Blockers; D000077149:Sevoflurane; C052853:5-hydroxydecanoic acid