Aging and its Impact on Innate Immunity and Inflammation: Implications for Periodontitis.
The elderly exhibit increased susceptibility to a number of inflammatory or degenerative pathologies. Aging is similarly thought to be associated with increased prevalence and severity of periodontitis, although the underlying causes are poorly understood. Among the plausible mechanisms whereby aging could contribute to increased susceptibility to periodontitis are age-dependent alterations in the innate immune and inflammatory status of the host. This hypothesis is supported by studies in humans and animal models outlined in this Review. Indeed, innate immune cells isolated from elderly subjects exhibit age-related cell-intrinsic defects that could predispose the elderly to deregulated immune and inflammatory responses. Moreover, the investigation of age-related alterations in the tissue environment where recruited inflammatory cells ultimately function could provide complementary, if not better, insights into the impact of aging on periodontitis. Integrative approaches combiningin vitroandin vivomechanistic models are underway and can potentially contribute to targeted molecular therapies that can reverse or mitigate the effects of aging on periodontitis and other inflammatory diseases.
Department of Microbiology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania, PA 19104, USA.
George
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Hajishengallis