Severity of disability in patients with cerebral palsy secondary to symptomatic congenital cytomegalovirus encephalopathy.
OBJECTIVE
Cytomegalovirus (CMV) is a leading cause of congenital encephalopathy and cerebral palsy (CP). In this study we report the severity of disability in individuals who developed CP secondary to symptomatic congenital CMV encephalopathy.


METHODS
The medical records of patients with CP secondary to symptomatic congenital CMV encephalopathy diagnosed from 1995 to 2011 were retrospectively reviewed. Gross Motor Functional Classification Scale (GMFCS) level, language function, and swallowing function were collected.


RESULTS
Twenty-three patients were found. Of those 23 patients, 83% (19/23) were at a GMFCS level IV or V, 9% (2/23) each GMFCS level II or III and none (0%) at GMFCS I. Eighteen patients were non-verbal, 3 had minimal to moderate verbal skills and 2 had no verbal impairment. Eighteen patients also had severe dysphagia requiring gastrostomy tube (GT) feedings, and 5 ate orally. There was a strong correlation between the severity of GMFCS and having a gastrostomy tube (p< 0.0006) and GMFCS and verbal skills (p< 0.0023).


CONCLUSIONS
This study shows that patients with CP secondary to symptomatic congenital cytomegalovirus encephalopathy have a very high risk of having severe physical and cognitive disabilities. This information can help healthcare providers and caregivers plan for the potential long-term medical, rehabilitation, and financial needs of this group of patients.
Gillette Children's Specialty Healthcare, St. Paul, MN, USA.
Nathan A
NA
Cameron
Gillette Children's Specialty Healthcare, St. Paul, MN, USA Deptartment of Physical Medicine and Rehabilitation, University of Minnesota School of Medicine, Minneapolis, MN, USA.
Mark E
ME
Gormley
Gillette Children's Specialty Healthcare, St. Paul, MN, USA Deptartment of Physical Medicine and Rehabilitation, University of Minnesota School of Medicine, Minneapolis, MN, USA.
Supreet
S
Deshpande
D001925:Brain Damage, Chronic / Q000150:complications* / Q000151:congenital; D002547:Cerebral Palsy / Q000209:etiology*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000151:congenital; D003680:Deglutition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013064:Speech Disorders / Q000209:etiology*
Cerebral palsy; cytomegalovirus; encephalopathy; gross motor function classification system