Bis(2,2,2-trifluoroethyl) carbonate as a condensing agent in one-pot parallel synthesis of unsymmetrical aliphatic ureas.
One-pot parallel synthesis of unsymmetrical aliphatic ureas was achieved with bis(2,2,2-trifluoroethyl) carbonate. The procedure worked well for both the monosubstituted and functionalized alkyl amines and required no special conditions (temperature control, order, or rate of addition). A library of 96 diverse ureas was easily synthesized.
Enamine Ltd. , 23 Matrosova Street, Kyiv, 01103, Ukraine.
Andrey V
AV
Bogolubsky
Yurii S
YS
Moroz
Pavel K
PK
Mykhailiuk
Dmitry S
DS
Granat
Sergey E
SE
Pipko
Anzhelika I
AI
Konovets
Roman
R
Doroschuk
Andrey
A
Tolmachev
D004952:Esters / Q000737:chemistry*; D015394:Molecular Structure; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
D004952:Esters; D014508:Urea