Motor neuron disease: a chemical perspective.
This Perspective provides a background to the pathogenesis of neurodegenerative disease and specifically amyotrophic lateral sclerosis (ALS) and gives an overview of the many pathways, both genetically inheritable and sporadic, that may lead to the premature activation of apoptotic pathways in neurons, as well as current and proposed approaches toward interrupting these pathways.
School of Chemistry, Monash University , Clayton, Victoria 3800, Australia.
Laura K
LK
Wood
Steven J
SJ
Langford
D027322:Amino Acid Transport System X-AG / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis; D004195:Disease Models, Animal; D015316:Genetic Therapy; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D008822:Mice, Transgenic; D008928:Mitochondria / Q000378:metabolism; D009154:Mutation; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D000072105:Superoxide Dismutase-1
D027322:Amino Acid Transport System X-AG; D000975:Antioxidants; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D017470:Receptors, Glutamate; C000606290:SOD1 protein, human; D018698:Glutamic Acid; C000606291:Sod1 protein, mouse; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1