Delayed graft function in pediatric deceased donor kidney transplantation: donor-related risk factors and impact on two-yr graft function and survival: a single-center analysis.
There is mounting evidence that the quality of organs from cadaver donors may be influenced by events occurring around the time of brain death. Aim of this present study was to analyze the correlation of DGF with brain-dead donor variables in a single-center pediatric population and to evaluate DGF influence on patients- and grafts outcome. End-points of the study were DGF prevalence, DGF donor-related risk factors, graft function, patient- and graft survival rate, respectively, at six, 12, and 24 months FU. The univariate analysis showed that donor age above 15 yr and vascular cause of donor brain death represented risk factors for DGF. The multivariate analysis confirmed as independent risk factors for DGF donor age >15 yr. At six months FU, DGF showed a negative impact on graft function. In conclusion, among all considered brain-dead donor resuscitation parameters, just non-traumatic cause of death turned out to be of impact for DGF. Donor age >15 yr represented the only independent risk factor for prolonged DGF in our series of children. At two-yr FU, DGF showed a transient negative impact on six-month graft function.
Pediatric Surgery, University of Padova, Padova, Italy.
Eleonora
E
Cesca
Giulia
G
Ghirardo
Rim
R
Kiblawi
Luisa
L
Murer
Piergiorgio
P
Gamba
Giovanni Franco
GF
Zanon
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001926:Brain Death; D002648:Child; D051799:Delayed Graft Function / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D063868:Patient Outcome Assessment; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors; D055815:Young Adult
children; chronic renal failure; delayed graft function; graft function; graft survival; kidney transplantation