[Atopic dermatitis severity and vitamin D concentration: a cross-sectional study].
BACKGROUND
Contradictory findings have recently been published on the association between atopic dermatitis (AD) severity and vitamin D deficiency. The aim of this study was to examine the correlation between 25-hydroxyvitamin D (25(OH)D) concentration and AD severity.


METHODS
A cross-sectional study was conducted from June 2011 to March 2013 in dermatology departments in adults and children with a diagnosis of AD. The severity of AD was assessed using the SCORAD and PO-SCORAD indexes and serum 25(OH)D concentrations were determined for all patients.


RESULTS
Sixty patients were included: 30 with severe AD and 30 with mild-to-moderate AD. The 25(OH)D concentration was lower in patients with severe AD than in patients with mild-to-moderate AD (15.9 ± 8.3 ng/mL vs. 21.5 ± 8.2 ng/mL; P=0.01). There was a negative correlation between 25(OH)D concentration and respectively, SCORAD (r=-0.47; P<0.001) and PO-SCORAD (r=-0.4; P=0.004) values. The correlation between 25(OH)D concentrations and SCORAD values remained valid after adjustment for age, phototype and season.


CONCLUSIONS
This study demonstrated an association between vitamin D deficiency and AD severity but showed no causal link between these variables. Confounding variables such as sun exposure and socioeconomic status were not recorded. A large-sale, comparative interventional study could confirm a real link between these two variables.
Service de dermatologie, CHU, 2, rue Henri-le-Guilloux, 35000 Rennes, France. Electronic address: sophieronceray@hotmail.fr.
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Ronceray
Service de dermatologie, CHU, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
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Benkalfate
Service de dermatologie, CHU, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
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Saillard
Service de dermatologie et dermatologie pédiatrique, hôpital Saint-André, CHU, 1, rue Jean-Burguet, 33000 Bordeaux, France.
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Ezzedine
Service de dermatologie, CHU, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
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Adamski
Service de dermatologie, CHU, 2, rue Henri-le-Guilloux, 35000 Rennes, France; Inserm EA 203, unité de pharmaco-épidémiologie, service de dermatologie, CIC, CHU de Rennes, université Rennes-1, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex 9, France.
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Dupuy
Service de dermatologie, CHU, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
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Droitcourt
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003876:Dermatitis, Atopic / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000175:diagnosis*
D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D
Atopic dermatitis; Deficiency; Dermatite atopique; Déficit; Vitamin D; Vitamine D