PEEP role in ICU and operating room: from pathophysiology to clinical practice.
Positive end expiratory pressure (PEEP) may prevent cyclic opening and collapsing alveoli in acute respiratory distress syndrome (ARDS) patients, but it may play a role also in general anesthesia. This review is organized in two sections. The first one reports the pathophysiological effect of PEEP on thoracic pressure and hemodynamic and cerebral perfusion pressure. The second section summarizes the knowledge and evidence of the use of PEEP in general anesthesia and intensive care. More specifically, for intensive care this review refers to ARDS and traumatic brain injured patients.
Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Naples "Federico II," 80100 Naples, Italy.
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M
Vargas
Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
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Y
Sutherasan
Department of Critical Care Medicine, "Città della Salute e della Scienza" Hospital, 10121 Turin, Italy.
C
C
Gregoretti
Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, 16132 Genoa, Italy.
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P
Pelosi
D000768:Anesthesia, General / Q000379:methods; D001930:Brain Injuries / Q000503:physiopathology / Q000628:therapy; D006321:Heart / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D007362:Intensive Care Units; D008168:Lung / Q000503:physiopathology; D009873:Operating Rooms; D011175:Positive-Pressure Respiration / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy