The Relationship between Serum 25-Hydroxyvitamin D, Parathyroid Hormone and the Glomerular Filtration Rate in Korean Adults: The Korea National Health and Nutrition Examination Survey between 2009 and 2011.
BACKGROUND
The glomerular filtration rate (GFR) decreases with age, while parathyroid hormone (PTH) increases. There are a few reports only on the relationship between GFR and PTH under the category of serum 25-hydroxyvitamin D (25[OH]D) concentration.


METHODS
Using the Korea National Health and Nutrition Examination Survey (KNHANES) data, a cross-sectional study was conducted on the association between serum 25(OH)D concentration, GFR and PTH in Korean adults aged 50 years or older. Serum PTH concentration was compared to the tertiles of GFR after adjustment for relevant variables. In addition, the serum PTH concentration was compared with the GFR under the category of serum 25(OH) D concentration (<20, 20-30, >30 ng/mL).


RESULTS
The mean estimated GFR (eGFR) was 74.8 mL/min in men and 73.1 mL/min in women. The mean PTH and 25(OH) D was 66.8 pg/mL, 20.5 ng/mL in men and 69.0 pg/mL, 18.2 ng/mL in women. The serum PTH concentration showed a significant negative correlation with the serum 25(OH) D and eGFR in both genders. The serum PTH concentration significantly increased at the lower tertile of eGFR in male adults In addition, a decrease of serum PTH concentration was marked in the vitamin D sufficient male adults (>30 ng/mL).


CONCLUSIONS
This present study demonstrated that serum PTH concentration showed negative correlation with eGFR, however, serum PTH increase may be minimized by maintaining proper serum 25(OH)D concentrations under similar eGFR status in Korean adults aged 50 and above.
Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea.
Sung-Woo
SW
Han
Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea.
Sung-Jin
SJ
Kim
Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea.
Duck-Joo
DJ
Lee
Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea.
Kwang-Min
KM
Kim
Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea.
Nam-Seok
NS
Joo
25-Hydroxyvitamin D; Glomerular Filtration Rate; Parathyroid Hormone