Preparation and characteristics of sodium alginate/Na(+)rectorite-g-itaconic acid/acrylamide hydrogel films.
Sodium alginate/Na(+)rectorite-graft-itaconic acid/acrylamide (SA/Na(+)REC-g-IA/AM) hydrogel film was prepared via solution polymerization. The effect of Na(+)REC, KPS, and NMBA content and the ratio of IA to AM on graft ratio, graft efficiency and absorption of liquids were investigated. The structure and morphology were analyzed by FTIR, XRD, TEM and SEM. Results revealed that the optimal Na(+)REC, KPS, and NMBA content and the ratio of IA to AM were 2wt%, 0.8wt%, 0.38wt% and 4, respectively. The hydrogel film was found to exhibit an intercalative structure and coarse surface. The mechanism of graft copolymerization was discussed. A slower and more continuous release of salicylic acid for SA/Na(+)REC-g-IA/AM composite hydrogel film was shown in vitro drug-controlled release studies, in comparison with SA film. The salicylic acid release mechanism of SA/Na(+)REC-g-IA/AM hydrogel film followed Fickian diffusion.
College of chemistry and chemical engineering, Xianyang Normal University Xianyang, Shaanxi 712000, PR China. Electronic address: lianli1968@163.com.
Lianli
L
Yang
Department of Applied Chemistry, School of Science Northwestern Polytechnical University Xi'an, Shaanxi 710072, PR China.
Xiaoyan
X
Ma
College of chemistry and chemical engineering, Xianyang Normal University Xianyang, Shaanxi 712000, PR China.
Naini
N
Guo
College of chemistry and chemical engineering, Xianyang Normal University Xianyang, Shaanxi 712000, PR China.
Yang
Y
Zhang
D020106:Acrylamide / Q000138:chemical synthesis / Q000737:chemistry*; D000464:Alginates / Q000138:chemical synthesis / Q000737:chemistry*; D000538:Aluminum Silicates / Q000138:chemical synthesis / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000008:administration & dosage; D002414:Cations, Monovalent / Q000138:chemical synthesis / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D020723:Glucuronic Acid / Q000138:chemical synthesis / Q000737:chemistry; D006603:Hexuronic Acids / Q000138:chemical synthesis / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis / Q000737:chemistry*; D008903:Minerals / Q000138:chemical synthesis / Q000737:chemistry*; D058105:Polymerization; D020156:Salicylic Acid / Q000008:administration & dosage; D013386:Succinates / Q000138:chemical synthesis / Q000737:chemistry*
D000464:Alginates; D000538:Aluminum Silicates; D000890:Anti-Infective Agents; D002414:Cations, Monovalent; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D008903:Minerals; D013386:Succinates; C546376:rectorite; D020106:Acrylamide; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D020723:Glucuronic Acid; D020156:Salicylic Acid; C005229:itaconic acid
Characteristics; Controlled release; Hydrogel film; Preparation; SA/Na(+)REC-g-IA/AM; Salicylic acid