Advances in acetabular osteolysis: biomarkers, imaging, and pharmacologic management.
Acetabular osteolysis can be difficult to diagnose because patients often have no clinical symptoms even when there is substantial bone loss. Ideally, early detection would lead to early interventions. Imaging continues to be the frontline modality for the early detection of acetabular osteolysis. Although plain radiography is the current imaging modality most commonly used in routine follow-up examinations, its low sensitivity limits its usefulness. CT and MRI have proven to be better imaging modalities for the early detection of osteolysis; however, their use is limited by cost, radiation exposure, and time. Biomarkers hold promise for the early detection of osteolysis; however, their efficacy requires more rigorous research for validation. Early diagnosis and treatment of osteolysis may lead to better outcomes for patients.
Resident, Department of Orthopaedic Surgery, Southern Illinois University School of Medicine, Springfield, Illinois.
Kenneth D
KD
Illingworth
Nathan
N
Wachter
William J
WJ
Maloney
Wayne G
WG
Paprosky
Michael D
MD
Ries
Khaled J
KJ
Saleh
D000077:Acetabulum; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000295:instrumentation; D015415:Biomarkers / Q000378:metabolism; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D006622:Hip Prosthesis / Q000009:adverse effects; D006801:Humans; D010014:Osteolysis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D011475:Prosthesis Failure
D015415:Biomarkers; D050071:Bone Density Conservation Agents