The lifelong effects of early childhood adversity and toxic stress.
A rapidly expanding body of research indicates that early social environments characterized by adversity, subordination and stress, along with individual differences in susceptibility to such environments, create risks for lifelong chronic diseases, including declines in oral health. Emerging findings suggest that gene-environment interplay, resulting in epigenetically regulated differences in gene expression, underlie many such declines in health. The origins of these processes in early life reveal how many of the chronic morbidities of adulthood should be viewed as developmental disorders, with etiologic roots in childhood.
Professor of Pediatrics and Psychiatry and heads the Division of Developmental-Behavioral Pediatrics, University of California, San Francisco, Calif., USA. Tom.Boyce@ucsf.edu.
W Thomas
WT
Boyce
D000293:Adolescent; D001921:Brain / Q000254:growth & development; D002648:Child; D002653:Child Behavior Disorders / Q000209:etiology; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D002908:Chronic Disease; D004245:DMF Index; D003733:Dental Caries Susceptibility / Q000502:physiology; D004198:Disease Susceptibility / Q000503:physiopathology; D044127:Epigenesis, Genetic; D059647:Gene-Environment Interaction; D006304:Health Status; D006801:Humans; D011203:Poverty; D012307:Risk Factors; D012923:Social Class; D064890:Social Determinants of Health; D012931:Social Environment; D013312:Stress, Physiological / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology