Generation of prostate IMAT plans adaptable to the inter-fractional changes of patient geometry.
We present the results of 2-Step generation of adaptable IMAT plans for prostate carcinoma cases. The 2-Step IMAT plans show clinical and dosimetric equivalence to the reference SmartArc™-generated VMAT plans. The 2-Step plans are adapted to inter-fractional changes of prostate-rectum geometry using 2-Step adaptation rules for a cohort of ten adaptation cases. The adapted 2-Step IMAT plans show statistically significant improvement (Wilcoxon 1-tail p < 0.05) of target coverage and of rectum sparing when compared to isocenter relocated plans.
Klinik und Poliklinik für Strahlentherapie, Universitätsklinikum Würzburg, Joseph-Schneider Str. 11, D-97080 Würzburg, Germany.
K
K
Holubyev
M
M
Gainey
K
K
Bratengeier
B
B
Polat
M
M
Flentje
D019583:Dose Fractionation, Radiation; D006801:Humans; D008297:Male; D058958:Organs at Risk / Q000033:anatomy & histology / Q000528:radiation effects; D011467:Prostate / Q000473:pathology* / Q000528:radiation effects; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects; D012007:Rectum / Q000033:anatomy & histology / Q000528:radiation effects