Chemical profiling of Jinqi Jiangtang tablets by HPLC-ESI-Q-TOF/MS.
OBJECTIVE
To profile the chemical constituents in Jinqi Jiangtang tablets.


METHODS
Based on the chromatographic retention behavior, fragmentation patterns of chemical components, and published literatures, a high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (HPLC-ESI-Q-TOF/MS) method was established to characterize and identify components in Jinqi Jiangtang tablets.


RESULTS
A total of 52 chemical compounds, including eight iridoid glycosides, seven phenolic acids, twelve alkaloids, six flavonoids, and nineteen saponins, were identified in Jinqi Jiangtang tablets.


CONCLUSIONS
The established method could serve as a powerful tool for structural characterization and quality control of this Chinese herbal preparation.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Shi
S
Sun
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Zhi-Shen
ZS
Xie
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
E-Hu
EH
Liu
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Yu-Ting
YT
Yan
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: xiaojunxu2000@163.com.
Xiao-Jun
XJ
Xu
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: liping2004@126.com.
Ping
P
Li
D000470:Alkaloids / Q000032:analysis; D027883:Astragalus Plant; D002851:Chromatography, High Pressure Liquid; D039323:Coptis; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005419:Flavonoids / Q000032:analysis; D057889:Iridoid Glycosides / Q000032:analysis; D031239:Lonicera; D010636:Phenols / Q000032:analysis; D012503:Saponins / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D057889:Iridoid Glycosides; C529953:Jinqi; D010636:Phenols; D012503:Saponins
Astragali Radix; Coptidis Rhizoma; HPLC-ESI-Q-TOF/MS; Jinqi Jiangtang tablets; Lonicerae Japonicae Flos; Mass spectrometry