[Chondrocyte microenvironment and application of microfluidic chips in constructing chondrocyte microenvironment].
OBJECTIVE
To review the chondrocyte survival microenvironment and the research progress of the application of microfluidic chips in constructing the chondrocyte microenvironment.


METHODS
Recent literature about the role of microenvironment in the regulation of chondrocytes and the application of microfluidic chips in constructing the chondrocyte microenvironment was reviewed and analyzed.


RESULTS
Regulating the microenvironment of chondrocyte mainly involves extracellular matrix microenvironment, mechanical microenvironment, electric microenvironment, and hypoxic microenvironment. Currently, the related research of chondrocyte microenvironment based on microfluidic system mainly involves biochemical stimuli, mechanical stimuli, production of biomimetic scaffold materials, and so on.


CONCLUSIONS
It will be helpful for constructing cartilage tissue being closer to the physiological function in the future to deeply understand chondrocyte survival environment and to mimic the microenvironment in vivo required by chondrocyte development as possible by using microfluidic chips.
Weiliang
W
Zhong
Weiguo
W
Zhang
D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000166:cytology / Q000502:physiology*; D018929:Cell Culture Techniques / Q000379:methods; D002454:Cell Differentiation; D002465:Cell Movement; D002478:Cells, Cultured; D060833:Cellular Microenvironment; D019902:Chondrocytes / Q000166:cytology / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000379:methods; D011509:Proteoglycans / Q000096:biosynthesis; D013314:Stress, Mechanical; D023822:Tissue Engineering / Q000379:methods
D016326:Extracellular Matrix Proteins; D011509:Proteoglycans