Reduced intensity allogeneic stem cell transplant for treatment of blastic plasmacytoid dendritic cell neoplasm.
Blastic plasmacytoid dendritic cell neoplasm is a rare, aggressive tumor characterized by skin and/or marrow infiltration by CD4(+) CD56(+) cells. Historically, the tumor was variably thought to arise from either monocytes, T cells or NK cells giving rise to terms such as CD4(+)/CD56(+) acute monoblastic leukemia, primary cutaneous CD4(+)/CD56(+) hematodermic tumor and blastic NK-cell lymphoma. Whilst considerable progress has been made in understanding the histogenesis, the best modality of treatment remains to be defined. We are therefore reporting this case which was successfully treated with a T-deplete allogeneic transplant and the patient is currently alive and in remission 4 years post transplant.
Hematology Department, University Hospital Walsgrave , Coventry, UK.
Anand
A
Lokare
Hematology Department, Heart of England Hospital NHS Trust , Birmingham, UK.
Emmanouil
E
Nikolousis
Hematology Department, University Hopital North Staffordshire , Stoke on Trent, UK.
Neil
N
Phillips
Histopathology Department, Heart of England NHS Trust , Birmingham, UK.
Zbigniew
Z
Rudzki
Hematology Department, Heart of England Hospital NHS Trust , Birmingham, UK.
Richard
R
Lovell
Hematology Department, Heart of England Hospital NHS Trust , Birmingham, UK.
Bhuvan
B
Kishore
Hematology Department, Heart of England Hospital NHS Trust , Birmingham, UK.
Don
D
Milligan
Hematology Department, Heart of England Hospital NHS Trust , Birmingham, UK.
Shankara
S
Paneesha
T-deplete; blastic plasmacytoid dendritic neoplasm; reduced intensity allograft