Animal models in studies of cardiotoxicity side effects from antiblastic drugs in patients and occupational exposed workers.
Cardiotoxicity is an important side effect of cytotoxic drugs and may be a risk factor of long-term morbidity for both patients during therapy and also for staff exposed during the phases of manipulation of antiblastic drugs. The mechanism of cardiotoxicity studied in vitro and in vivo essentially concerns the formation of free radicals leading to oxidative stress, with apoptosis of cardiac cells or immunologic reactions, but other mechanisms may play a role in antiblastic-induced cardiotoxicity. Actually, some new cytotoxic drugs like trastuzumab and cyclopentenyl cytosine show cardiotoxic effects. In this report we discuss the different mechanisms of cardiotoxicity induced by antiblastic drugs assessed using animal models.
Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine, Area of Occupational Medicine, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy.
Monica
M
Lamberti
Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine, Area of Occupational Medicine, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy.
Giancarlo
G
Giovane
Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine, Area of Occupational Medicine, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy.
Elpidio M
EM
Garzillo
National Institute for the Study and Treatment of Cancer, Foundation "G. Pascale", Via Mariano Semmola, 80131 Napoli, Italy.
Franca
F
Avino
Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy.
Antonia
A
Feola
Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy.
Stefania
S
Porto
Department of Radiology, Oncology and Pathological Anatomy Sciences, University of Rome, "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy ; Spencer-Lorillard Foundation, University of Rome, "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy.
Vincenzo
0000-0001-5359-9991
V
Tombolini
Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy ; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Building Suite 431, 1900 North 12th Street, Philadelphia, PA 19122, USA.
Marina
0000-0002-6201-4200
M
Di Domenico
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D066126:Cardiotoxicity / Q000188:drug therapy* / Q000473:pathology; D006321:Heart / Q000187:drug effects*; D006801:Humans; D051379:Mice; D023421:Models, Animal; D018384:Oxidative Stress; D051381:Rats
D000970:Antineoplastic Agents