Paradigm lost: a perspective on the design and interpretation of regenerative endodontic research.
Regenerative endodontic procedures are rapidly gaining the attention of clinicians and investigators alike. However, it is often challenging to understand various regenerative studies and to interpret their results. The present review addresses this problem by focusing on recent strategies for developing standardized clinical protocols, understanding the full spectrum of clinical and translational research and its relationship to selection of proper outcome measures, as well as reviewing the fundamental role of paradigms in designing and interpreting regenerative studies.
Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas. Electronic address: Hargreaves@uthscsa.edu.
Kenneth M
KM
Hargreaves
Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Anibal
A
Diogenes
Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Fabricio B
FB
Teixeira
D002985:Clinical Protocols / Q000592:standards; D003782:Dental Pulp / Q000502:physiology*; D003788:Dental Pulp Diseases / Q000628:therapy*; D004708:Endodontics / Q000592:standards; D055094:Evidence-Based Dentistry; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D012107:Research Design / Q000592:standards
Mesenchymal stem cells; pulp biology; regenerative endodontics