Diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD): a review.
This review presents an overview of studies investigating white-matter integrity in patients with obsessive-compulsive disorder (OCD) using diffusion tensor imaging (DTI). There is increasing evidence for white matter alterations in OCD. In adult patients the majority of all studies reported abnormalities in terms of decreased fractional anisotropy (FA) compared to healthy volunteers. Although findings are heterogeneous, the cingulate bundle, the corpus callosum and the anterior limb of the internal capsule are most commonly affected by decreased white matter integrity in adult OCD patients. In pediatric and adolescent patients initial evidence points more towards increased white matter connectivity. Thus, current results suggest alterations in various white matter regions in both pediatric and adult OCD patients. They indicate that alterations may vary as a function of clinical characteristics and may be amenable to pharmacologic treatment. Although the findings have important implications for the neurobiology of OCD they also raise a number of important questions that are discussed in this review and need to be taken into consideration in future studies.
Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany; TUM-Neuroimaging Center of Klinikum rechts der Isar (TUM-NIC), Technische Universität München TUM, Ismaninger Strasse 22, 81675 Munich, Germany; Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany. Electronic address: kathrin.koch@tum.de.
Kathrin
K
Koch
Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany; TUM-Neuroimaging Center of Klinikum rechts der Isar (TUM-NIC), Technische Universität München TUM, Ismaninger Strasse 22, 81675 Munich, Germany; Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Groβhaderner Strasse 2, 82152 Munich, Germany.
Tim J
TJ
Reess
Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany; TUM-Neuroimaging Center of Klinikum rechts der Isar (TUM-NIC), Technische Universität München TUM, Ismaninger Strasse 22, 81675 Munich, Germany; Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Groβhaderner Strasse 2, 82152 Munich, Germany.
O Georgiana
OG
Rus
Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany.
Claus
C
Zimmer
Windach Institute and Hospital of Neurobehavioural Research and Therapy (WINTR), Psychosomatic Hospital, Windach, Schützenstraße 100, 86949 Windach, Germany.
Michael
M
Zaudig
D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D003337:Corpus Callosum; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis*
Corpus callosum; DTI; FA; Internal capsule; OCD; Obsessive-compulsive; Review; White matter