Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages.
BACKGROUND
Due to the emergency of multidrug-resistant strains of Mycobacterium tuberculosis, is necessary the evaluation of new compounds.


RESULTS
Tedizolid, a novel oxazolidinone, and ACH-702, a new isothiazoloquinolone, were tested against M. tuberculosis infected THP-1 macrophages. These two compounds significantly decreased the number of intracellular mycobacteria at 0.25X, 1X, 4X and 16X the MIC value. The drugs were tested either in nanoparticules or in free solution.


CONCLUSIONS
Tedizolid and ACH-702 have a good intracellular killing activity comparable to that of rifampin or moxifloxacin.
Servicio de Dermatología, Hopital Universitario, UANL, C,P, Monterrey, NL 64460, Mexico. carmelia7@hotmail.com.
Carmen A
CA
Molina-Torres
Alejandra
A
Barba-Marines
Orestes
O
Valles-Guerra
Jorge
J
Ocampo-Candiani
Norma
N
Cavazos-Rocha
Michael J
MJ
Pucci
Jorge
J
Castro-Garza
Lucio
L
Vera-Cabrera
D000995:Antitubercular Agents / Q000494:pharmacology*; D058491:Bacterial Load; D002460:Cell Line; D006801:Humans; D008264:Macrophages / Q000382:microbiology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D010755:Organophosphates / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
C550937:ACH 702; D000995:Antitubercular Agents; D010755:Organophosphates; D010080:Oxazoles; D015363:Quinolones; D013844:Thiazoles; C515040:tedizolid phosphate