One Patient, Two Uncommon B-Cell Neoplasms: Solitary Plasmacytoma following Complete Remission from Intravascular Large B-Cell Lymphoma Involving Central Nervous System.
Second lymphoid neoplasms are an uncommon but recognized feature of non-Hodgkin's lymphomas, putatively arising secondary to common genetic or environmental risk factors. Previous limited evaluations of clonal relatedness between successive mature B-cell malignancies have yielded mixed results. We describe the case of a man with intravascular large B-cell lymphoma involving the central nervous system who went into clinical remission following immunochemotherapy and brain radiation, only to relapse 2 years later with a plasmacytoma of bone causing cauda equina syndrome. The plasmacytoma stained strongly for the cell cycle regulator cyclin D1 on immunohistochemistry, while the original intravascular large cell lymphoma was negative, a disparity providing no support for clonal identity between the 2 neoplasms. Continued efforts atcataloging and evaluating unique associations of B-cell malignancies are critical to improving understanding of overarching disease biology in B-cell malignancies.
Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Outram Road, Singapore 169610.
Joycelyn
J
Lee
Department of Pathology, Singapore General Hospital, 11 Jalan Tan Tock Seng, Singapore 169608.
Soo Yong
SY
Tan
Department of Pathology, Singapore General Hospital, 11 Jalan Tan Tock Seng, Singapore 169608.
Leonard H C
LH
Tan
Department of Pathology, Tan Tock Seng Hospital, Singapore 308433.
Hwei Yee
HY
Lee
Department of Pathology, Tan Tock Seng Hospital, Singapore 308433.
Khoon Leong
KL
Chuah
Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Outram Road, Singapore 169610.
Tiffany
T
Tang
Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Outram Road, Singapore 169610.
Richard
R
Quek
Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Outram Road, Singapore 169610.
Kevin
K
Tay
Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Outram Road, Singapore 169610.
Miriam
M
Tao
Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Outram Road, Singapore 169610.
Soon Thye
ST
Lim
Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Outram Road, Singapore 169610.
Mohamad
M
Farid