Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
In plants, the activation of immunity is often inversely correlated with growth. Mechanisms that control plant growth in the context of pathogen challenge and immunity are unclear. Investigating Arabidopsis infection with the powdery mildew fungus, we find that the Arabidopsis atypical E2F DEL1, a transcriptional repressor known to promote cell proliferation, represses accumulation of the hormone salicylic acid (SA), an established regulator of plant immunity. DEL1-deficient plants are more resistant to pathogens and slightly smaller than wild-type. The resistance and size phenotypes of DEL1-deficient plants are due to the induction of SA and activation of immunity in the absence of pathogen challenge. Moreover, Enhanced Disease Susceptibility 5 (EDS5), a SA transporter required for elevated SA and immunity, is a direct repressed target of DEL1. Together, these findings indicate that DEL1 control of SA levels contributes to regulating the balance between growth and immunity in developing leaves.
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720-3102, USA.
Divya
D
Chandran
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720-3102, USA.
Joshua
J
Rickert
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720-3102, USA.
Yingxiang
Y
Huang
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720-3102, USA.
Michael A
MA
Steinwand
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720-3102, USA.
Sharon K
SK
Marr
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720-3102, USA. Electronic address: mwildermuth@berkeley.edu.
Mary C
MC
Wildermuth
D017360:Arabidopsis / Q000254:growth & development / Q000276:immunology* / Q000382:microbiology; D029681:Arabidopsis Proteins / Q000276:immunology / Q000378:metabolism*; D049109:Cell Proliferation; D018506:Gene Expression Regulation, Plant; D007113:Immunity, Innate; D026901:Membrane Transport Proteins / Q000276:immunology / Q000378:metabolism*; D010935:Plant Diseases / Q000276:immunology / Q000382:microbiology; D018515:Plant Leaves / Q000276:immunology; D004718:Saccharomycetales / Q000254:growth & development* / Q000276:immunology / Q000472:pathogenicity; D020156:Salicylic Acid / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology*
D029681:Arabidopsis Proteins; C500416:DEL1 protein, Arabidopsis; C455514:EDS5 protein, Arabidopsis; D026901:Membrane Transport Proteins; D014157:Transcription Factors; D020156:Salicylic Acid