Validation of a novel clinical prediction score for severe coronary artery diseases before elective coronary angiography.
OBJECTIVE
Coronary artery disease (CAD) severity is associated with patient prognosis. However, few efficient scoring systems have been developed to screen severe CAD in patients with stable angina and suspected CAD before coronary angiography. Here, we present a novel scoring system for CAD severity before elective coronary angiography.


METHODS
Five hundred fifty-one patients with stable angina who were admitted for coronary angiography were enrolled in this study. Patients were divided into training (n = 347) and validation (n = 204) cohorts. Severe CAD was defined as having a Gensini score of 20 or more. All patients underwent echocardiography (ECG) to detect ejection fraction and aortic valve calcification (AVC). Multivariable analysis was applied to determine independent risk factors and develop the scoring system.


RESULTS
In the training cohort, age, male sex, AVC, abnormal ECG, diabetes, hyperlipidemia, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were identified as independent factors for severe CAD by multivariable analysis, and the Severe Prediction Scoring (SPS) system was developed. C-indices of receiver operating characteristic (ROC) curves for severe CAD were 0.744 and 0.710 in the training and validation groups, respectively. The SPS system also performed well during calibration, as demonstrated by Hosmer-Lemeshow analysis in the validation group. Compared with the Diamond-Forrester score, the SPS system performed better for severe CAD prediction before elective coronary angiography.


CONCLUSIONS
Severe CAD prediction was achieved by analyzing age, sex, AVC, ECG, diabetes status, and lipid levels. Angina patients who achieve high scores using this predicting system should undergo early coronary angiography.
Department of Cardiology, Zhongshan Hospital affiliated to Fudan University, Shanghai, China.
Zhang-Wei
ZW
Chen
Department of Endocrinology Medicine, East Hospital affiliated to Tongji University, Shanghai, China.
Ying-Hua
YH
Chen
Department of Cardiology, Zhongshan Hospital affiliated to Fudan University, Shanghai, China.
Ju-Ying
JY
Qian
Department of Cardiology, Zhongshan Hospital affiliated to Fudan University, Shanghai, China.
Jian-Ying
JY
Ma
Department of Cardiology, Zhongshan Hospital affiliated to Fudan University, Shanghai, China.
Jun-Bo
JB
Ge
D000368:Aged; D000787:Angina Pectoris / Q000175:diagnosis; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index