Evaluation of DNA binding with some selected hydrazide and semicarbazide derivatives.
A group of hydrazide and semicarbazide derivatives containing isopropylidene, benzylidene, cyclohexylidene, and phospholidene groups was synthesized and characterized by spectroscopic techniques. These compounds were tested for DNA interaction studies monitored by UV-Vis and IR data as well as molecular docking. Investigations on interactions of these compounds with DNA revealed an intercalative mode of binding between them. It is interesting to note that semicarbazide derivatives with aliphatic substituents showed better DNA binding than the aromatic substituents.
Department of Chemistry, School of Advanced Sciences, VIT University, Vellore, 632 014, Tamil Nadu, India.
Sannapaneni
S
Janardan
Pothini
P
Suman
G
G
Swapna
A
A
Amrita
R
R
Priya
Ramamoorthy
R
Siva
Kari
K
Vijayakrishna
Akella
A
Sivaramakrishna
D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D018736:DNA Adducts / Q000737:chemistry / Q000378:metabolism; D062105:Molecular Docking Simulation; D009584:Nitrogen / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D012663:Semicarbazides / Q000737:chemistry* / Q000378:metabolism*; D013816:Thermodynamics
D018736:DNA Adducts; D012663:Semicarbazides; C010059:carbamylhydrazine; D004247:DNA; D009584:Nitrogen