Platelet glycoprotein IIIa gene polymorphism (Leu33Pro) and aspirin resistance in a very elderly Chinese population.
OBJECTIVE
To study the relationship between platelet glycoprotein IIIa gene (GP IIIa) polymorphism (Leu33Pro) and aspirin resistance in a very elderly Chinese population.


METHODS
Four hundred fifty very elderly Chinese people receiving aspirin therapy were enrolled in the study. Patients who underwent arachnoid acid-induced platelet aggregation were then divided into two groups based on their resistance to aspirin: aspirin-resistant (AR) group (n=236) and aspirin-sensitive (AS) group (n=214). The Leu33Pro polymorphism of the GP IIIa gene was scanned by polymerase chain reaction-restriction fragment-length polymorphism.


RESULTS
In the AR group, 224 participants had the A1/A1 genotype and 12 had the A1/A2 genotype. All patients in the AS group had the A1/A1 genotype. Thus, there was significant difference between these two groups in the genotype distribution (p<0.05).


CONCLUSIONS
The genetic polymorphism of the GP IIIa gene was associated with AR in a very elderly Chinese population.
Department of Geratology, Sixth People's Hospital, affiliated to Shanghai Jiaotong University , Shanghai, China .
Bei-Yun
BY
Wang
Shi-Jin
SJ
Tan
D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000008:administration & dosage*; D001483:Base Sequence; D018955:CD36 Antigens / Q000235:genetics*; D017931:DNA Primers; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D006801:Humans; D007930:Leucine / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011392:Proline / Q000235:genetics*
D018955:CD36 Antigens; D017931:DNA Primers; D011392:Proline; D007930:Leucine; D001241:Aspirin