Synthesis and characterization of a novel semi-IPN hydrogel based on Salecan and poly(N,N-dimethylacrylamide-co-2-hydroxyethyl methacrylate).
Salecan is a novel water-soluble, high molecular mass extracellular β-glucan produced by Agrobacterium sp. ZX09. Salecan has excellent physicochemical and biological properties, making it very suitable for hydrogel preparation. In this study, a series of novel semi-interpenetrating polymer network (semi-IPN) hydrogels containing Salecan and poly(N,N-dimethylacrylamide-co-2-hydroxyethylmethacrylate) (poly(DMAA-co-HEMA)) were synthesized by radical polymerization and semi-IPN technology. Structure and morphology of the hydrogels were characterized by FTIR, XRD, TGA and SEM. The semi-IPNs had a well-interconnected porous structure with tunable pore size ranging from 6 to 41μm. Swelling capability of the hydrogels was improved by introducing the hydrophilic Salecan. Rheological results indicated that the incorporation of poly(DMAA-co-HEMA) into hydrogels enhanced the storage modulus. Compression tests revealed that these semi-IPNs were robust materials with compressive modulus between 13.3 and 90.5kPa, the addition of Salecan increased the fracture strain from 71.1% to 88.8%. Degradation and cytotoxicity tests demonstrated that semi-IPNs were degradable and non-toxic.
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China.
Xinyu
X
Hu
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China.
Liandong
L
Feng
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China.
Wei
W
Wei
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China.
Aming
A
Xie
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China.
Shiming
S
Wang
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China.
Jianfa
J
Zhang
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China. Electronic address: dongwei@njust.edu.cn.
Wei
W
Dong
D000178:Acrylamides / Q000138:chemical synthesis* / Q000378:metabolism; D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000378:metabolism; D008689:Methacrylates / Q000138:chemical synthesis* / Q000378:metabolism; D011108:Polymers / Q000138:chemical synthesis / Q000378:metabolism; D012212:Rheology; D014961:X-Ray Diffraction; D047071:beta-Glucans / Q000138:chemical synthesis* / Q000378:metabolism
D000178:Acrylamides; D008689:Methacrylates; D011108:Polymers; D047071:beta-Glucans; C429790:poly(N,N-dimethylacrylamide); C577623:salecan; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C005044:hydroxyethyl methacrylate
Poly(DMAA-co-HEMA); Porous structure; Robust materials; Salecan; Semi-IPN hydrogels