Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens.
The biosynthesis of tropodithietic acid was investigated using a combinatorial approach of feeding experiments, gene knockouts and bioinformatic analyses. The mechanism of sulfur introduction is distinct from known mechanisms in holomycin, thiomarinol A and gliotoxin biosynthesis.
Institut für Organische Chemie, Hagenring 30, 38106 Braunschweig, Germany. j.dickschat@tu-braunschweig.de.
Nelson L
NL
Brock
Alexander
A
Nikolay
Jeroen S
JS
Dickschat
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry; D041902:Rhodobacteraceae / Q000378:metabolism*; D014334:Tropolone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
D000900:Anti-Bacterial Agents; C527336:tropodithietic acid; D014334:Tropolone