Endoplasmic reticulum targeted chemotherapeutics: the remarkable photo-cytotoxicity of an oxovanadium(IV) vitamin-B6 complex in visible light.
An oxovanadium(IV) vitamin-B6 Schiff base complex, viz. [VO(HL)(acdppz)]Cl, having (acridinyl)dipyridophenazine (acdppz) shows specific localization to endoplasmic reticulum (ER) and remarkable apoptotic photocytotoxicity in visible light (400-700 nm) in HeLa and MCF-7 cancer cells (IC50 < 0.6 μM) while being non-toxic in the dark and to MCF-10A normal cells (IC50 > 40 μM).
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India. arc@ipc.iisc.ernet.in.
Samya
S
Banerjee
Akanksha
A
Dixit
Radhika N
RN
Shridharan
Anjali A
AA
Karande
Akhil R
AR
Chakravarty
D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000528:radiation effects*; D006367:HeLa Cells; D006801:Humans; D008027:Light; D061986:MCF-7 Cells; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D012545:Schiff Bases / Q000737:chemistry; D014638:Vanadates / Q000737:chemistry*; D025101:Vitamin B 6 / Q000737:chemistry*
D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D012545:Schiff Bases; C075743:oxovanadium IV; D014638:Vanadates; D025101:Vitamin B 6