Loss of microstructural integrity in the limbic-subcortical networks for acute symptomatic traumatic brain injury.
Previous studies reported discrepant white matter diffusivity in mild traumatic brain injury (mTBI) on the base of Glasgow Coma Scale, which are unreliable for some TBI severity indicators and the frequency of missing documentation in the medical record. In the present study, we adopted the Mayo classification system for TBI severity. In this system, the mTBI is also divided into two groups as "probable and symptomatic" TBI. We aimed to investigate altered microstructural integrity in symptomatic acute TBI (<1 week) by using tract-based spatial statics (TBSS) approach. A total of 12 patients and 13 healthy volunteers were involved and underwent MRI scans including conventional scan, and SWI and DTI. All the patients had no visible lesions by using conventional and SWI neuroimaging techniques, while showing widespread declines in the fractional anisotropy (FA) of gray matter and white matter throughout the TBSS skeleton, particularly in the limbic-subcortical structures. By contrast, symptomatic TBI patients showed no significant enhanced changes in FA compared to the healthy controls. A better understanding of the acute changes occurring following symptomatic TBI may increase our understanding of neuroplasticity and continuing degenerative change, which, in turn, may facilitate advances in management and intervention.
Department of Medical Imaging, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China ; Medical Imaging Centre, An Kang Central Hospital, 85-Jinzhou South Road, AnKang 725000, China.
Yanan
Y
Zhu
Medical Imaging Centre, An Kang Central Hospital, 85-Jinzhou South Road, AnKang 725000, China.
Zhengjun
Z
Li
The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Lijun
L
Bai
The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Yin
Y
Tao
The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Chuanzhu
C
Sun
Department of Medical Imaging, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China.
Min
M
Li
Medical Imaging Centre, An Kang Central Hospital, 85-Jinzhou South Road, AnKang 725000, China.
Longmei
L
Zheng
Medical Imaging Centre, An Kang Central Hospital, 85-Jinzhou South Road, AnKang 725000, China.
Bao
B
Zhu
Medical Imaging Centre, An Kang Central Hospital, 85-Jinzhou South Road, AnKang 725000, China.
Jun
J
Yao
Medical Imaging Centre, An Kang Central Hospital, 85-Jinzhou South Road, AnKang 725000, China.
Heping
H
Zhou
Department of Medical Imaging, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China.
Ming
M
Zhang
D000328:Adult; D016880:Anisotropy; D001930:Brain Injuries / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D003710:Demography; D056324:Diffusion Tensor Imaging; D005260:Female; D066128:Gray Matter / Q000473:pathology; D006801:Humans; D008032:Limbic System / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000473:pathology; D066127:White Matter / Q000473:pathology; D055815:Young Adult