Acute toxicity associated with analytically confirmed recreational use of methiopropamine (1-(thiophen-2-yl)-2-methylaminopropane).
OBJECTIVE
Methiopropamine use in Europe has been detected since January 2011, but there is limited information on its acute toxicity. Here, we describe a case of analytically confirmed methiopropamine acute toxicity.


METHODS
A 27-year-old woman with no previous medical history was brought to the emergency department with palpitations, chest tightness, anxiety, nausea, vomiting and visual hallucinations following the use of a 'Quicksilver'. Toxicological analysis of her urine collected at presentation to the ED detected methiopropamine at a concentration of 400 ng/mL. Other drugs were also detected but at a much lower concentration.


CONCLUSIONS
This is the first ever case report of analytically confirmed acute toxicity related to methiopropamine use. It confirms the potential for significant acute toxicity with cardiovascular, gastrointestinal and psychotic symptoms thus providing further information to help with managing these patients and allow legislative authorities to consider the need for its control.
Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, London, UK, hweemindhammika.lee@gstt.nhs.uk.
Hwee Min D
HM
Lee
David M
DM
Wood
Simon
S
Hudson
John R H
JR
Archer
Paul I
PI
Dargan
D000208:Acute Disease; D000328:Adult; D005260:Female; D006801:Humans; D013287:Illicit Drugs / Q000633:toxicity*; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000633:toxicity; D013876:Thiophenes / Q000633:toxicity*
C583008:1-(2-thienyl)-2-(methylamino)propane; D013287:Illicit Drugs; D013876:Thiophenes; D008694:Methamphetamine