[Does neuroendocrine differentiation have prognostic value in prostate core needle biopsies?].
OBJECTIVE
The biological behaviour of prostate cancer (PCa) varies significantly and cannot be, therefore, predicted. Better understanding of the mechanisms underpinning PCa oncogenesis and progression with its yet-to-be discovered poor prognostic factors is essential in order to optimise and tailor treatment to an individual patient. The aim of this paper was to investigate the association between the rate of focal PCa neuroendocrine activity, tumour cell proliferation index score, and the rate of PCa positive core needle biopsy results.


METHODS
92 men, with histologically confirmed PCa, which was clinically confined to the prostate and was graded with Gleason score > or =7, had their core needle biopsies under transrectal ultrasonography guidance performed. The PCa neuroendocrine activity was immunohistochemically confirmed using antibodies against Chromogranin-A and neuron specific enolase.


RESULTS
The neuroendocrine activity was detected in 14 (13%) out of 92 PCa patients participating in the study. The proliferative index was not increased in non-cancerous prostate cells. There was no relationship between PCa neuroendocrine activity, the number and percentage of PCa positive biopsies, prostate volume, serum PSA concentration, and Gleason score found.


CONCLUSIONS
No association between selected PCa prognostic factors and neuroendocrine activity could be found in patients with organ confined prostate cancer.
Jarosław
J
Jaskulski
Tomasz
T
Gołabek
Janusz
J
Kopczyński
Pawel
P
Orłowsk
Jakub
J
Bukowczan
Przemek
P
Dudek
Piotr
P
Chłosta
D000368:Aged; D062005:Biopsy, Large-Core Needle; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D053379:Chromogranin A / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D055099:Neuroendocrine Cells / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000473:pathology*
D053379:Chromogranin A; D010751:Phosphopyruvate Hydratase