Magnetic resonance imaging of a microvascular-interstitium model on a microfluidic device.
We report a microvascular-interstitium model on microfluidic devices to study leakage of drugs from blood vessels under in vivo-like flow conditions. We employed magnetic resonance imaging to demonstrate the compatibility of the model for experimental animals and humans. We observed transport of two types of different molecular-weight contrast agents into the model interstitium. The ratio of the transport rates of agents agreed with the ratio calculated from diffusion coefficients of the agents. We expect that the model will be useful for the estimation and evaluation of leakage of many kinds of agents in vivo.
Department of Chemical and Biological Sciences, Faculty of Science, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, Tokyo 112-8681, Japan; Department of Applied Chemistry, Faculty of Science and Engineering, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan. Electronic address: nsasaki@toyo.jp.
Naoki
N
Sasaki
Molecular Imaging Center, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage, Chiba 263-8555, Japan.
Jun-ichiro
J
Jo
Molecular Imaging Center, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage, Chiba 263-8555, Japan. Electronic address: aoki@nirs.go.jp.
Ichio
I
Aoki
Department of Chemical and Biological Sciences, Faculty of Science, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, Tokyo 112-8681, Japan.
Kae
K
Sato
D000818:Animals; D001808:Blood Vessels / Q000378:metabolism*; D003287:Contrast Media / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D046210:Microfluidic Analytical Techniques; D008954:Models, Biological
D003287:Contrast Media
Blood vessel; Gd-DTPA; Gd-labeled dextran; High-field MRI; Micro-imaging; Microfluidic device