Caspase-3, shears for synapse pruning.
Motor neurons regulate neuromuscular junction formation by using agrin to stimulate acetylcholine receptor clustering and using acetylcholine to disperse unnecessary receptor clusters on muscle fibers. Wang et al. (2014) now report in this issue of Developmental Cell a critical role for caspase-3 in intracellular mechanisms of acetylcholine-induced dispersal.
Department of Neuroscience and Regenerative Medicine and Department of Neurology, Medical College of Georgia, Georgia Regents University, 1120 15(th) Street, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA.
Chengyong
C
Shen
Department of Neuroscience and Regenerative Medicine and Department of Neurology, Medical College of Georgia, Georgia Regents University, 1120 15(th) Street, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA.
Wen C
WC
Xiong
Department of Neuroscience and Regenerative Medicine and Department of Neurology, Medical College of Georgia, Georgia Regents University, 1120 15(th) Street, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA. Electronic address: lmei@gru.edu.
Lin
L
Mei
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D053148:Caspase 3 / Q000378:metabolism*; D000072261:Dishevelled Proteins; D018482:Muscle, Skeletal / Q000378:metabolism*; D009469:Neuromuscular Junction / Q000502:physiology*; D010750:Phosphoproteins / Q000378:metabolism*; D055366:Synaptic Potentials / Q000502:physiology*; D009435:Synaptic Transmission
D048868:Adaptor Proteins, Signal Transducing; D000072261:Dishevelled Proteins; D010750:Phosphoproteins; D053148:Caspase 3