An uncommon cause of acquired osteosclerosis in adults: hepatitis C-associated osteosclerosis.
Hepatitis C-associated osteosclerosis (HCAO) is a rare sclerosing bone condition characterized by debilitating, predominantly lower extremity bone pain, accelerated bone turnover, and a generalized increase in histologically normal trabecular and cortical bone tissue. Herein we report the clinical presentation and imaging results of the 19th case of HCAO. Clinicians, particularly those caring for a population at risk for HCV infection, should be aware of this uncommon condition. The etio-pathogenesis of HCAO remains obscure but may bear important lessons in bone biology that could lead to new treatment options for osteoporosis.
Department of Internal Medicine, Marshfield Clinic, 1000 N. Oak Ave, Marshfield, WI, 54449, USA, enaren10@gmail.com.
Narendranath
N
Epperla
Fergus E
FE
McKiernan
D015502:Absorptiometry, Photon / Q000379:methods*; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000000981:diagnostic imaging*; D006801:Humans; D010026:Osteosclerosis / Q000000981:diagnostic imaging* / Q000209:etiology*; D051598:Whole Body Imaging