Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatric disorders.
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis of illicit drug use and drug-induced psychotic disorders (DIP), 187 substance users and 386 normal controls were recruited from Northern Taiwan. Substance users and normal controls significantly differed in allele frequencies of COMT Val158Met (p = 0.039) but not in allele frequencies of DAT1 3'-UTR VNTR (p = 0.879). However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 3'-UTR VNTR were associated with DIP. The findings should be confirmed in further studies of a larger sample size and a more homogenous patient group.
1Department of Psychiatry, Chang Gung Memorial Hospital at Keelung , Keelung , Taiwan.
Chih-Ken
CK
Chen
Shih-Ku
SK
Lin
Shu-Chuan
SC
Chiang
Lien-Wen
LW
Su
Liang-Jen
LJ
Wang
D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D013287:Illicit Drugs; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011605:Psychoses, Substance-Induced / Q000235:genetics*; D019966:Substance-Related Disorders / Q000235:genetics*; D013624:Taiwan; D055815:Young Adult
D050483:Dopamine Plasma Membrane Transport Proteins; D013287:Illicit Drugs; C493214:SLC6A3 protein, human; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase
COMT; DAT1; dopamine; genotype; mood disorder; psychosis; substance use; suicide