Reduced amygdala volume is associated with deficits in inhibitory control: a voxel- and surface-based morphometric analysis of comorbid PTSD/mild TBI.
A significant portion of previously deployed combat Veterans from Operation Enduring Freedom and Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) are affected by comorbid posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI). Despite this fact, neuroimaging studies investigating the neural correlates of cognitive dysfunction within this population are almost nonexistent, with the exception of research examining the neural correlates of diagnostic PTSD or TBI. The current study used both voxel-based and surface-based morphometry to determine whether comorbid PTSD/mTBI is characterized by altered brain structure in the same regions as observed in singular diagnostic PTSD or TBI. Furthermore, we assessed whether alterations in brain structures in these regions were associated with behavioral measures related to inhibitory control, as assessed by the Go/No-go task, self-reports of impulsivity, and/or PTSD or mTBI symptoms. Results indicate volumetric reductions in the bilateral anterior amygdala in our comorbid PTSD/mTBI sample as compared to a control sample of OEF/OIF Veterans with no history of mTBI and/or PTSD. Moreover, increased volume reduction in the amygdala predicted poorer inhibitory control as measured by performance on the Go/No-go task, increased self-reported impulsivity, and greater symptoms associated with PTSD. These findings suggest that alterations in brain anatomy in OEF/OIF/OND Veterans with comorbid PTSD/mTBI are associated with both cognitive deficits and trauma symptoms related to PTSD.
Institute of Cognitive Science, University of Colorado at Boulder, Boulder, CO 80309, USA ; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA.
B E
BE
Depue
VISN 19 Mental Illness Research Education and Clinical Center, Denver, CO 80220, USA ; University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.
J H
JH
Olson-Madden
Institute of Cognitive Science, University of Colorado at Boulder, Boulder, CO 80309, USA.
H R
HR
Smolker
VISN 19 Mental Illness Research Education and Clinical Center, Denver, CO 80220, USA.
M
M
Rajamani
VISN 19 Mental Illness Research Education and Clinical Center, Denver, CO 80220, USA ; University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.
L A
LA
Brenner
Institute of Cognitive Science, University of Colorado at Boulder, Boulder, CO 80309, USA ; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA.
M T
MT
Banich
D000328:Adult; D000679:Amygdala / Q000473:pathology / Q000503:physiopathology; D001930:Brain Injuries / Q000401:mortality / Q000503:physiopathology / Q000523:psychology; D003072:Cognition Disorders / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D007175:Impulsive Behavior; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D013313:Stress Disorders, Post-Traumatic / Q000401:mortality / Q000473:pathology / Q000523:psychology