Stochastic genome-nuclear lamina interactions: modulating roles of Lamin A and BAF.
The nuclear lamina (NL) is thought to aid in the spatial organization of interphase chromosomes by providing an anchoring platform for hundreds of large genomic regions named lamina associated domains (LADs). Recently, a new live-cell imaging approach demonstrated directly that LAD-NL interactions are dynamic and in part stochastic. Here we discuss implications of these new findings and introduce Lamin A and BAF as potential modulators of stochastic LAD positioning.
Division of Gene Regulation; Netherlands Cancer Institute; Amsterdam, the Netherlands.
Jop
J
Kind
Division of Gene Regulation; Netherlands Cancer Institute; Amsterdam, the Netherlands.
Bas
B
van Steensel
D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D016678:Genome; D006801:Humans; D034904:Lamin Type A / Q000378:metabolism*; D034881:Nuclear Lamina / Q000378:metabolism*; D013269:Stochastic Processes
D002843:Chromatin; D004268:DNA-Binding Proteins; D034904:Lamin Type A
BAF; LADs; Lamin A; Lamin B1; chromatin domains; nuclear organization; single cell