Generation of C(2)F(5)CHN(2) in situ and its first reaction: [3+2] cycloaddition with alkenes.
The novel chemical reagent, C2 F5 CHN2 , is generated in situ from C2 F5 CH2 NH2 ⋅HCl and sodium nitrite. It reacts with mono- and disubstituted electron-deficient alkenes at room temperature to afford C2 F5 -pyrazolines in excellent yields.
Organic Chemistry Department, Taras Shevchenko National University of Kyiv, Volodymyrska 64, 01601 Kyiv (Ukraine); Enamine Ltd. Matrosova 23, 01103 Kyiv (Ukraine). Pavel.Mykhailiuk@gmail.com, Pavel.Mykhailiuk@mail.enamine.net.
Pavel K
PK
Mykhailiuk
D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D061565:Cycloaddition Reaction; D005461:Fluorine / Q000737:chemistry*; D054879:Halogenation; D007202:Indicators and Reagents; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000475:Alkenes; D007202:Indicators and Reagents; D011720:Pyrazoles; D005461:Fluorine
cycloaddition; diazo compounds; fluorine; in situ generation; pyrazolines