Successful treatment of osseous blastomycosis without pulmonary or disseminated disease and review of the literature.
Blastomycosis commonly occurs following inhalation of Blastomyces dermatitidis conidia causing a pulmonary infection and can disseminate to extrapulmonary sites. Osseous involvement primarily results from hematogenous spread, but in rare cases, direct inoculation can occur. We describe a case of osseous blastomycosis without pulmonary or disseminated disease successfully treated with posaconazole.
Division of Infectious Diseases & International Health, University of Virginia Health System, Charlottesville, VA. Electronic address: sd9fw@virginia.edu.
Shandra R
SR
Day
Department of Orthopedic Surgery, University of Virginia Health System, Charlottesville, VA.
David B
DB
Weiss
Clinical Microbiology Laboratory, Department of Pathology, Duke University, Durham, NC.
Kevin C
KC
Hazen
Division of Infectious Diseases & International Health, University of Virginia Health System, Charlottesville, VA.
Christopher C
CC
Moore
D000935:Antifungal Agents / Q000627:therapeutic use*; D001758:Blastomyces; D001759:Blastomycosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D001847:Bone Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole
Blastomycosis; Cutaneous inoculation; Orthopedic infection