Clinical value of cystatin C and beta-trace protein in glomerular filtration rate in renal transplant cases with stable renal graft functions: comparison by the 99mTc-DTPA plasma sample method.
OBJECTIVE
The aim of this study was to investigate the value of cystatin C and beta-trace protein (BTP) levels in determination of the glomerular filtration rate (GFR) by accepting the technetium-99m diethylenetriamine pentaacetic acid (Tc-DTPA) method as the gold standard for GFR measurement in renal transplant patients with stable renal functions and to investigate the value of cystatin C and BTP levels in the determination of GFR in cases with or without renal tubular injury.


METHODS
A total of 89 (60 men and 29 women) renal transplant patients aged 19-67 years (mean 38.15 years) with stable graft functions were included in the study. GFR was calculated using three different methods: (a) the Tc-DTPA two plasma sample method; (b) eight different formulas containing cystatin C; and (c) three different formulas containing BTP. In addition, the cases were divided into two groups on the basis of N-acetyl-β-D-glucosaminidase and β2 microglobulin levels showing tubular damage.


RESULTS
GFR values obtained with cystatin C had a better correlation with the gold standard method compared with those obtained with BTP, and the GFR value obtained with cystatin C had the most reliable consistency. We found that cystatin C provided more accurate results in GFR follow-up in renal transplant patients with no tubular injury compared with those with tubular injury.


CONCLUSIONS
Cystatin C is a good marker of GFR in renal transplant patients, especially in those with no tubular injury; however, BTP is not as good as cystatin C in that regard.
aDepartment of Nuclear Medicine, Afyon Kocatepe University School of Medicine, Afyon Departments of bNuclear Medicine cBiochemistry dDepartment of Internal Medicine, Division of Nephrology, Akdeniz University School of Medicine, Antalya, Turkey.
Ali Ozan
AO
Oner
Funda
F
Aydin
Serkan
S
Demirelli
Evrim S
ES
Budak
Fatih
F
Davran
Halide
H
Akbas
Huseyin
H
Kocak
Gultekin
G
Suleymanlar
Firat
F
Gungor
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood*; D007677:Kidney Function Tests / Q000379:methods*; D016030:Kidney Transplantation; D054834:Lipocalins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016284:Technetium Tc 99m Pentetate / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; D055316:Cystatin C; D054834:Lipocalins; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase; D016284:Technetium Tc 99m Pentetate