Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against induced infections of Ancylostoma spp. nematodes of cats.
Four studies were conducted to examine the efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel (BROADLINE(®), Merial) against Ancylostoma tubaeforme and Ancylostoma braziliense hookworms of cats. In each study, purpose-bred cats were randomly assigned to treatment groups of 10 or 12 cats per group. In three studies the cats were inoculated with A. tubaeforme and in one study with A. braziliense. The inoculations were undertaken on a schedule which resulted in the hookworms reaching the fourth larval stage in two of the studies, or the adult stage in four of the studies, by the day of treatment. In each study there was also an untreated control and 1 or 2 groups treated with the novel combination. In the two studies where efficacy against the fourth larval stage of A. tubaeforme was tested, the efficacy recorded was 100%. In the three studies where efficacy against the adult stage of A. tubaeforme was tested, efficacy of 100% was also confirmed. In the study where efficacy against the adult stage of A. braziliense was tested efficacy was 99.5%.
Merial Ltd., Duluth, GA 30096, USA. Electronic address: joseph.prullage@merial.com.
Joseph B
JB
Prullage
Merial GmbH, Kathrinhof Research Center, 83101 Rohrdorf, Germany.
Martin
M
Knaus
Cheri Hill Kennel and Supply, Stanwood, MI USA.
Dwight D
DD
Bowman
Merial Ltd., Duluth, GA 30096, USA.
S Theodore
ST
Chester
Merial GmbH, Kathrinhof Research Center, 83101 Rohrdorf, Germany.
Martin
M
Visser
Merial GmbH, Kathrinhof Research Center, 83101 Rohrdorf, Germany.
Steffen
S
Rehbein
Merial Ltd., Duluth, GA 30096, USA.
Joseph
J
Rosentel
D000722:Ancylostoma / Q000502:physiology; D000724:Ancylostomiasis / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004338:Drug Combinations; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives; D008726:Methoprene / Q000008:administration & dosage; D011223:Praziquantel / Q000008:administration & dosage; D011720:Pyrazoles / Q000008:administration & dosage; D011897:Random Allocation; D016896:Treatment Outcome
D000977:Antiparasitic Agents; D004338:Drug Combinations; D011720:Pyrazoles; D011223:Praziquantel; D007559:Ivermectin; C101434:eprinomectin; D008726:Methoprene; C082360:fipronil
(S)-methoprene; Ancylostoma braziliense; Ancylostoma tubaeforme; Eprinomectin; Fipronil; Praziquantel