Infective endocarditis after renal transplantation.
BACKGROUND
Infective endocarditis (IE) is a serious complication in immunosuppressive patients that has adverse effects.


OBJECTIVE
The aim of this study was to define the characteristics, outcomes, and correlating factors of mortality in renal transplant recipients.


METHODS
Infective endocarditis was diagnosed in 22 patients from three renal transplant centers in Iran between 2000 and 2010. Modified Duke criteria were applied to confirm the diagnosis.


RESULTS
Twenty-two renal transplant patients with IE were evaluated. Blood culture results were positive in 81%. Enteroccous and group D non-enterococcal were the causative microorganisms in 31% and 25% of patients, respectively. In-hospital and 12-month mortality was 41% and the mortality rate was higher in older patients in comparison to younger patients. Overall, the rates of one-year disease-free patient and graft survival were 49% and 88%, respectively.


CONCLUSIONS
Despite the availability of different and potent antibiotics, the mortality caused by IE remains considerably high. These patients are significantly prone to endovascular infections that affect the mortality and survival.
Cardiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Maryam
M
Moshkani Farahani
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Zohreh
Z
Rostami
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Behzad
B
Einollahi
Cardiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Arezoo
A
Khosravi
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Eghlim
E
Nemati
Departement of Nephrology, Tehran University of Medical Sciences, Tehran, IR Iran.
Mahboob
M
Lessan Pezeshki
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Vahid
V
Pourfarziani
Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Nematollah
N
Joneidi
Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Mohammad Javad
MJ
Hosseini
Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Gholam Ali
GA
Ghorbani
Endocarditis; Infection; Kidney Transplantation