L-leucine supplementation worsens the adiposity of already obese rats by promoting a hypothalamic pattern of gene expression that favors fat accumulation.
Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat mass was increased in l-leucine-supplemented rats consuming the HFD. Accordingly, l-leucine produced a hypothalamic pattern of gene expression that favors fat accumulation. In conclusion, l-leucine supplementation worsened the adiposity of rats previously exposed to HFD possibly by central mechanisms.
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil. thaizampieri@gmail.com.
Thais T
TT
Zampieri
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil. torresleal@ufpi.edu.br.
Francisco L
FL
Torres-Leal
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil. amanda.baron@gmail.com.
Amanda B
AB
Campaña
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil. fabio@icb.usp.br.
Fabio B
FB
Lima
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil. jdonato@icb.usp.br.
Jose
J
Donato
D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D019587:Dietary Supplements; D002149:Energy Intake; D015870:Gene Expression; D007031:Hypothalamus / Q000378:metabolism*; D007930:Leucine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009765:Obesity / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D007930:Leucine