Near complete resolution of refractory, relapsed, metastatic Wilms' tumour in an adolescent with bevacizumab.
Wilms' tumour is common among children but rare in adults. Children with Wilms' tumour have better prognosis even when diagnosed at advanced stage. We report the case of an adolescent girl with chemo-resistant metastatic Wilms' tumour treated previously with two lines of chemotherapy. Upon progression on second line chemotherapy, there was a partial response to Bevacizumab based combination chemotherapy in the third line. Patient was referred for high dose chemotherapy and autologous stem cell therapy. The latter could not be achieved. The patient had a relapse 3 months later and succumbed to the disease.
Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Shiyam
S
Kumar
Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Ikram A
IA
Burney
Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Mansour S
MS
Al-Moundhri
D000293:Adolescent; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000068258:Bevacizumab; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology; D059146:Metastasectomy; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D009396:Wilms Tumor / Q000188:drug therapy* / Q000473:pathology
D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab