[Morphological tissue changes after the implantation of a biodegradable material on collagen basis].
The objective of this study was to examine the peculiarities of tissue reactions during the degradation of "Collost" bioplastic material on the collagen basis with completely preserved fibrous structure, after its implantation into the bone tissue defect. The defect in bone tissue sized 1-2 mm x 3-5 mm was created in tibial condyle. The study was performed on 24 Wistar rats using light microscopic methods. The tissue reactions were studied at different time intervals (1, 2, 6 and 12 months) after the implantation of collagenic material. It was found that after the implantation, the material became impregnated with blood, and due to fibrin, densely adhered to the damaged tissues. Further, the cells were found to migrate along the blood clot into its depth from the surrounding tissues. These were primarily the fibroblasts which were located in a network of fibers and started to absorb collagen from a surrounding material and to synthesize new collagen. Gradually, the collagenic material became similar to a cell-containing network. The volume of the newly synthesized collagen increased, and after some time all the foreign material was absorbed by fibroblasts and replaced with connective tissue. After 1 year, a large "Collost" fragment was completely degraded and replaced by loose connective tissue. The implantation of a collagenic material did not stimulate the formation of a delimiting connective tissue capsule
I V
IV
Maĭborodin
E A
EA
Beregovoĭ
A I
AI
Shevela
I V
IV
Kuznetsova
M I
MI
Barannik
A A
AA
Manaev
V I
VI
Maĭborodina
D020341:Absorbable Implants / Q000009:adverse effects*; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000601:surgery; D003094:Collagen / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use; D003238:Connective Tissue / Q000187:drug effects / Q000601:surgery; D005347:Fibroblasts / Q000187:drug effects; D051381:Rats
D003094:Collagen