Considerations in individualizing prophylaxis in patients with haemophilia A.
Prophylaxis is considered optimal care for children and adults with severe haemophilia A because of its proven ability to reduce joint and other bleeding episodes. However, a 'one size fits all' approach to prophylaxis is not ideal, potentially leading to over-treatment in some individuals and under-treatment in others. Moreover, a generic plan fails to take into account a patient's lifestyle and personal preferences. This article reviews the factors contributing to bleeding risk and joint damage and uses case studies to illustrate how these contributors can be weighed to individualize the prophylactic regimen, thereby increasing the likelihood of therapeutic success.
Rush Hemophilia and Thrombophilia Center, Department of Pediatrics, Rush Children's Hospital and Rush University Medical Center, Chicago, IL, USA.
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Valentino
D000367:Age Factors; D000368:Aged; D003029:Coagulants / Q000008:administration & dosage*; D005169:Factor VIII / Q000008:administration & dosage*; D006395:Hemarthrosis / Q000517:prevention & control; D006467:Hemophilia A / Q000188:drug therapy*; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D057285:Precision Medicine / Q000379:methods*; D012307:Risk Factors; D055815:Young Adult
D003029:Coagulants; D005169:Factor VIII
FVIII; haemophilia; individualizing; personalizing; prophylaxis