Folates are potential ligands for ruthenium compounds in vivo.
Under physiologically relevant conditions, cis-bis(2,2'-bipyridine)dichlororuthenium(II), [cis-Ru(2,2'-bipy)2Cl2] was observed to bind to folic acid via replacement of the two chloride ligands. This binding was shown to be pH dependent and afforded diastereomers, the structures of which were determined by 1- and 2D NMR spectroscopic techniques. We propose that when studying the cytotoxicity of labile ruthenium complexes in cells, folate coordination should be considered.
The University of Cambridge Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK. pdb30@cam.ac.uk srb39@cam.ac.uk.
Tom G
TG
Scrase
Simon M
SM
Page
Paul D
PD
Barker
Sally R
SR
Boss
D015082:2,2'-Dipyridyl / Q000737:chemistry; D005492:Folic Acid / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D008024:Ligands; D009942:Organometallic Compounds; D015082:2,2'-Dipyridyl; D012428:Ruthenium; D005492:Folic Acid