Palladium-catalyzed C(sp(3))-H activation: a facile method for the synthesis of 3,4-dihydroquinolinone derivatives.
3,4-Dihydroquinolinones were synthesized by the palladium-catalyzed, oxidative-addition-initiated activation and arylation of inert C(sp(3) )H bonds. Pd(OAc)2 and P(o-tol)3 were used as the catalyst and ligand, respectively, to improve the efficiency of the reaction. A further advantage of this reaction is that it could be performed in air. A relatively rare seven-membered palladacycle was proposed as a key intermediate of the catalytic cycle.
Beijing National Laboratory of Molecular Sciences (BNLMS), PKU Green Chemistry Centre and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing, 100871 (China).
Jia-Xuan
JX
Yan
Hu
H
Li
Xiang-Wei
XW
Liu
Jiang-Ling
JL
Shi
Xin
X
Wang
Zhang-Jie
ZJ
Shi
D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D015363:Quinolones / Q000737:chemistry*
D015363:Quinolones; D010165:Palladium
CH activation; dihydroquinolinones; palladacycles; palladium; synthetic methods