Highly diastereo- and enantioselective Michael addition of 3-substituted benzofuran-2(3H)-ones to 4-oxo-enoates catalyzed by lanthanide(III) complexes.
An efficient lanthanide(III)-catalyzed diastereo- and enantioselective Michael addition of 3-substituted benzofuran-2(3H)-ones to 4-oxo-enoates was developed. The desired adducts with contiguous quaternary-tertiary stereocenters were obtained in up to 99% yield with up to >95/5 dr and 98% ee.
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn.
Zhen
Z
Wang
Qian
Q
Yao
Tengfei
T
Kang
Juhua
J
Feng
Xiaohua
X
Liu
Lili
L
Lin
Xiaoming
X
Feng
D001572:Benzofurans / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D007811:Lanthanum / Q000737:chemistry*; D013237:Stereoisomerism
D001572:Benzofurans; D056831:Coordination Complexes; D007811:Lanthanum; C105430:benzofuran