α-Adducin gene G614T polymorphisms in essential hypertension patients with high low density lipoprotein (LDL) levels.
OBJECTIVE
The association between α-adducin gene G614T polymorphism and essential hypertension (EH) is not clear. The present study was carried out to examine a possible association between α-adducin gene G614T mutation and essential hypertension in Chinese population.


METHODS
A total of 170 patients with essential hypertension (EH group) and 154 normotensive subjects (Control group) were genotyped for the cytoskeletal protein single nucleotide polymorphism G614T of the α-adducin gene by PCR-RFLP technique. Systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), low density lipoprotein (LDL), high-density lipoprotein (HDL), high-sensitivity C-reactive protein (hs-CRP), left atrial diameter (LA DIA), left ventricular diameter (LV DIA) and other parameters were recorded in EH group.


RESULTS
There was significant association between EH and α-adducin genotypes (P<0.05). GT and TT genotypes in EH group had higher LDL levels as compared to GG carriers (P<0.05). The LDL concentration was significantly elevated in patients with GT and TT genotypes. The LDL levels also differed significantly in male patients with all the three genotypes.


CONCLUSIONS
A significant association was found between ADD1 gene G614T polymorphism and EH in Chinese patients. Further studies need to be done to confirm these findings in a large sample.
Lifang
L
Wang
Bin
B
Zheng
Zhejiang Cancer Hospital, Hangzhou, China.
Hongguang
H
Zhao
Peng
P
Du
Aihua
A
Sun
Kouzhen
K
Hua
Yuyu
Y
Gao
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D000075222:Essential Hypertension; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics* / Q000473:pathology; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000099291:Adducins
D002097:C-Reactive Protein; D002148:Calmodulin-Binding Proteins; D008077:Lipoproteins, LDL; D000099291:Adducins