[Current status and future perspective in inherited cardiac arrhythmias].
Some patients with inherited cardiac arrhythmias such as congenital long QT syndrome (LQTS), Brugada syndrome, and early repolarization syndrome (ERS) have a link to mutations in genes encoding for ion channels or other membrane components. The diagnosis and management for inherited cardiac arrhythmias have been updated in recently published HRS/EHRA/APHRS Expert Consensus Statement. More recently, an exome study or whole genome study by using next generation sequencer as well as a genome-wide association study (GWAS) by using a gene array have been introduced to identify a new responsible gene or to explore the role of common genetic variants (polymorphisms) as a susceptible or modifier gene in inherited cardiac arrhythmias.
Wataru
W
Shimizu
D001145:Arrhythmias, Cardiac / Q000235:genetics*; D053840:Brugada Syndrome / Q000235:genetics; D006801:Humans; D008133:Long QT Syndrome / Q000235:genetics