The relationship between serum sialic acid and high-sensitivity C-reactive protein with prehypertension.
BACKGROUND
The aim of our study was to evaluate the serum concentration of sialic acid (SA) and high-sensitivity C-reactive protein (hs-CRP) in prehypertensive patients and the possible correlations between these 2 factors with blood pressure in such patients.


METHODS
We studied 61 prehypertensive patients, 70 hypertensive patients, and 50 controls with normal blood pressure. Lipid profile, hs-CRP, SA, and body mass index (BMI) were estimated in all groups. Associations between SA and hs-CRP and blood pressure were analyzed using multiple linear regressions.


RESULTS
SA and hs-CRP levels were higher in the prehypertension group than that in the control group and were lower than that in the hypertension group. Multiple linear regression demonstrated that fasting glucose, BMI, SA, and hs-CRP correlated with systolic blood pressure and that low-density lipoprotein, BMI, SA, and hs-CRP correlated independently with diastolic pressure (P<0.05).


CONCLUSIONS
Our findings suggest that in prehypertension, there is an association between serum SA and hs-CRP levels and blood pressure.
Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China (mainland).
Li
L
Jinghua
Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China (mainland).
Zhang
Z
Tie
Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China (mainland).
Wang
W
Ping
Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China (mainland).
Cao
C
Yongtong
D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003971:Diastole; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology; D016014:Linear Models; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D058246:Prehypertension / Q000097:blood* / Q000503:physiopathology; D013599:Systole
D002097:C-Reactive Protein; D019158:N-Acetylneuraminic Acid