Genetic fuzzy system predicting contractile reactivity patterns of small arteries.
Monitoring of physiological surrogate end points in drug development generates dynamic time-domain data reflecting the state of the biological system. Conventional data analysis often reduces the information in these data by extracting specific data points, thereby discarding potentially useful information. We developed a genetic fuzzy system (GFS) algorithm that is capable of learning all information in time-domain physiological data. Data on isometric force development of isolated small arteries were used as a framework for developing and optimizing a GFS. GFS performance was improved by several strategies. Results show that optimized fuzzy systems (OFSs) predict contractile reactivity of arteries accurately. In addition, OFSs identified significant differences that were undetectable using conventional analysis in the responses of arteries between groups. We concluded that OFSs may be used in clustering or classification tasks as aids in the objective identification or prediction of dynamic physiological behavior.
Department of Drug Design and Pharmacology, Systems Pharmacology Section, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
J
J
Tang
Department of Drug Design and Pharmacology, Systems Pharmacology Section, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
M
M
Sheykhzade
Department of Drug Design and Pharmacology, Systems Pharmacology Section, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
B F
BF
Clausen
Department of Drug Design and Pharmacology, Systems Pharmacology Section, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
H C M
HC
Boonen