Polymorphisms of the heart-type fatty acid-binding protein as a prognostic factor in patients with atherosclerosis.
The amount of heart-type fatty acid-binding protein (FABP3) in cardiomyocytes may affect the prognosis of patients with coronary atherosclerosis. In this study, we examined whether single nucleotide polymorphisms (SNPs) of the FABP3 gene were prognostic factors in patients with coronary atherosclerosis. We enrolled 100 patients with myocardial infarction and coronary atherosclerosis and 100 healthy individuals to assess the genotypes of four SNPs of the FABP3 gene (RS2271072, RS16834408, RS2279885, and RS10914367). The MI patients with coronary atherosclerosis exhibited a higher frequency (16%) of the C/G-G/G haplotype of RS2271072 and RS10914367 than healthy individuals (7%). Koreans with the C/G-G/G haplotype for these SNPs had a higher risk of MI than did Koreans with the G/G-A/A haplotype. We calculated an odds ratio of 2.83 (95% confidence interval: 1.01-7.96). In conclusion, the C/G-G/G haplotype at RS2271072 and RS10914367 SNPs of FABP3 might be a prognostic factor in patients with coronary atherosclerosis.
Departments of Laboratory Medicine, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, 271, Cheon bo-Ro, Uijeong bu, Korea, 480-717; phone: 82 31 820 3159; fax: 82 31 847 6266; email: hkl@cathlic.ac.kr.
Yeongsic
Y
Kim
Soo-Young
SY
Kim
Yonggoo
Y
Kim
Hi Jeong
HJ
Kwon
Jung Rok
JR
Kim
Hae Kyung
HK
Lee
Ki-Dong
KD
Yoo
D044466:Asian People / Q000235:genetics; D050197:Atherosclerosis / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis
C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins
heart-type fatty acid-binding protein; myocardial infarction; polymorphism