title: Blood pressure control and perceived health status in African Americans with subclinical hypertensive heart disease.
abstract: The role of antihypertensive therapy in reducing the risk of cardiovascular complications such as heart failure is well established, but the effects of different blood pressure goals on patient-perceived health status has not been well defined. We sought to determine if adverse effects on perceived health status will occur with lower blood pressure goals or more intensive antihypertensive therapy. Data were prospectively collected as a part of a single center, randomized controlled trial designed to evaluate standard (Seventh Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure-compliant) versus intense (<120/80 mm Hg) blood pressure goals for patients with uncontrolled hypertension and subclinical hypertensive heart disease. Blood pressure management was open label, and health status was measured at 3-month intervals over 1 year of follow-up using the short-form (SF)-36. Mixed linear models were constructed for each of the SF-36 summary scores. One hundred twenty-three (mean age 49.4 ± 8.2; 65% female; 95.1% African American) patients were randomized, 88 of whom completed the protocol. With the exception of a decrease in perceived health transition, health status did not change significantly on repeat measurement. Lower blood pressure goals and more intensive antihypertensive therapy appear to be well tolerated with limited effects on patients' perception of health status.
authors.affiliation: Department of Emergency Medicine, Wayne State University, Detroit, MI, USA; College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA. Electronic address: burlamic@msu.edu.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Burla
authors.affiliation: Department of Emergency Medicine, Wayne State University, Detroit, MI, USA.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Brody
authors.affiliation: Division of Translational Research and Clinical Epidemiology and Department of Medicine, Wayne State University, Detroit, MI, USA.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Ference
authors.affiliation: Division of Translational Research and Clinical Epidemiology and Department of Medicine, Wayne State University, Detroit, MI, USA; Cardiovascular Research Institute, Wayne State University, Detroit, MI, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Flack
authors.affiliation: Department of Emergency Medicine, Wayne State University, Detroit, MI, USA; School of Medicine, Wayne State University, Detroit, MI, USA.
authors.forename: James J
authors.initials: JJ
authors.lastname: Mahn
authors.affiliation: Department of Emergency Medicine, Wayne State University, Detroit, MI, USA; College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Marinica
authors.affiliation: Department of Emergency Medicine, Wayne State University, Detroit, MI, USA; School of Medicine, Wayne State University, Detroit, MI, USA.
authors.forename: Justin A
authors.initials: JA
authors.lastname: Carroll
authors.affiliation: College of Education, Health, and Human Services, University of Michigan-Dearborn, Dearborn, MI, USA.
authors.forename: Samar A
authors.initials: SA
authors.lastname: Nasser
authors.affiliation: Division of Translational Research and Clinical Epidemiology and Department of Medicine, Wayne State University, Detroit, MI, USA.
authors.forename: Shiling
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Emergency Medicine, Wayne State University, Detroit, MI, USA; Cardiovascular Research Institute, Wayne State University, Detroit, MI, USA.
authors.forename: Phillip D
authors.initials: PD
authors.lastname: Levy
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D044383:Black People; D005260:Female; D006304:Health Status; D006331:Heart Diseases / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology; D016014:Linear Models; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D011446:Prospective Studies; D057566:Self Report; D011795:Surveys and Questionnaires; D001741:Black or African American
chemical_list: D000959:Antihypertensive Agents
keywords: Health status; hypertension; short form-36; subclinical hypertensive heart disease