title: A bubble-mediated intelligent microscale electrochemical device for single-step quantitative bioassays.
abstract: An intelligent microscale electrochemical device (iMED) for one-step, quantitative and multiplexed electrochemical detection of biomarkers for infectious diseases and tumors is developed. A "plug-in-cartridge" technology is introduced and adapted for use in screen-printed electrodes (SPEs) in electrochemical devices. Using this iMED, biomarkers for two types of tumors and one infectious disease are detected at sub-ng/mL levels in less than 30 min.
authors.affiliation: Division of Physical, Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Microscale Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China; School of Laboratory Medicine, Hubei University of Chinese Medicine, 1 Huangjia Lake West Road, Wuhan, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zuo
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Li
authors.forename: Wangping
authors.initials: W
authors.lastname: Deng
authors.forename: Jiye
authors.initials: J
authors.lastname: Shi
authors.forename: Guojun
authors.initials: G
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
authors.forename: Shiping
authors.initials: S
authors.lastname: Song
authors.forename: Chunhai
authors.initials: C
authors.lastname: Fan
mesh_terms: D001681:Biological Assay / Q000295:instrumentation*; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D004563:Electrochemistry / Q000295:instrumentation*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D007252:Influenza Vaccines / Q000032:analysis; D055616:Microtechnology / Q000295:instrumentation*; D017430:Prostate-Specific Antigen / Q000097:blood
chemical_list: D004129:Dimethylpolysiloxanes; D007252:Influenza Vaccines; C013830:baysilon; D017430:Prostate-Specific Antigen
keywords: bioassays; electrochemistry; electrodes; microfluidics; proteins