title: Hepatic ischemia/reperfusion injury is diminished by atorvastatin in Wistar rats.
abstract: OBJECTIVE
  Temporal occlusion of the hepatoduodenal ligament (HDL) is often used during liver surgeries in order to reduce blood loss, resulting in ischemia/reperfusion injury (I/R). The aim of the study was to investigate the effects of atorvastatin (ATOR) on hepatic I/R injury and on serum levels of tumor necrosis factor-alpha (TNF-α), endothelin-1 (ET-1), antithrombin III (ATIII) and intracellular adhesion molecule-1 (ICAM-1).
  
  
  METHODS
  Liver ischemia was induced in Wistar rats by clamping the HDL for 60 min, followed by either 60 or 180 min reperfusion. Rats received either vehicle or 10 mg/kg ATOR before hepatic I/R. Control group received sham surgery. Livers were examined for histological damage and serum AST, ALT, TNF-α, ET-1, ATIII and ICAM-1 concentrations were measured.
  
  
  RESULTS
  After I/R, AST and ALT were significantly elevated, ATIII levels were significantly depleted, both TNF-α and ICAM-1 levels increased and ET-1 was significantly elevated (at 180 min). ATOR pretreatment attenuated these alterations and diminished histological injury scores.
  
  
  CONCLUSIONS
  Our results show that ATOR protects the liver from I/R injury.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico. Electronic address: crcamara83@hotmail.com.
authors.forename: Carlos Rodrigo
authors.initials: CR
authors.lastname: Cámara-Lemarroy
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Guzmán-de la Garza
authors.affiliation: Servicio de Anatomía Patológica y Citopatología, Hospital Universitario "José Eleuterio González," Monterrey, Nuevo León, Mexico.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Alarcón-Galván
authors.affiliation: Unidad de Hígado, Departamento de Medicina Interna, Universidad Autónoma de Nuevo León, School of Medicine, Monterrey, Nuevo León, Mexico.
authors.forename: Paula
authors.initials: P
authors.lastname: Cordero-Pérez
authors.affiliation: Unidad de Hígado, Departamento de Medicina Interna, Universidad Autónoma de Nuevo León, School of Medicine, Monterrey, Nuevo León, Mexico.
authors.forename: Linda
authors.initials: L
authors.lastname: Muñoz-Espinosa
authors.affiliation: Unidad de Hígado, Departamento de Medicina Interna, Universidad Autónoma de Nuevo León, School of Medicine, Monterrey, Nuevo León, Mexico.
authors.forename: Liliana
authors.initials: L
authors.lastname: Torres-González
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
authors.forename: Nancy Esthela
authors.initials: NE
authors.lastname: Fernández-Garza
mesh_terms: D000818:Animals; D000990:Antithrombin III / Q000032:analysis; D000069059:Atorvastatin; D019332:Endothelin-1 / Q000097:blood; D006538:Heptanoic Acids / Q000627:therapeutic use*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008297:Male; D011758:Pyrroles / Q000627:therapeutic use*; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D019332:Endothelin-1; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; D000990:Antithrombin III; D000069059:Atorvastatin
keywords: Atorvastatin; Endothelial adhesion molecules; Ischemia/Reperfusion; Liver; Pro-inflammatory cytokines; Rat