title: Anti-inflammatory effects of green soybean extract irradiated with visible light.
abstract: We conducted a preliminary investigation of the effects of visible light irradiation on plant extracts, and we observed a strong suppressive effect on interleukin (IL) 2 expression with the inhibition of c-Jun amino-terminal kinase (JNK) phosphorylation in Jurkat cells by visible light irradiation to ethanol extract from green soybeans (LIEGS). This effect was produced only by extracts from green soybeans (Glycine max) and not other-color soybeans. LIEGS suppressed the lipopolysaccharide-induced IL-6, IL-12 and TNF-α expression levels in human monocyte THP-1 cells in a concentration-dependent manner. LIEGS was applied for 8 weeks to NC/Nga mice. LIEGS suppressed the development of atopic dermatitis (AD)-like skin lesions and reduced the dermatitis scores of the mice. The light irradiation changed the various types of small-molecule compounds in extracts. Visible light irradiation to daidzein with chlorophyll b induced a novel oxidative product of daidzein. This product suppressed IL-2 expression in Jurkat cells.
authors.affiliation: 1] Health Care Research Center, Nisshin Pharma Inc., 5-3-1, Fujimino, Saitama, 356-8511 Japan [2].
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: 1] Health Care Research Center, Nisshin Pharma Inc., 5-3-1, Fujimino, Saitama, 356-8511 Japan [2].
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohgo
authors.affiliation: Health Care Research Center, Nisshin Pharma Inc., 5-3-1, Fujimino, Saitama, 356-8511 Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Katayanagi
authors.affiliation: Health Care Research Center, Nisshin Pharma Inc., 5-3-1, Fujimino, Saitama, 356-8511 Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Yasui
authors.affiliation: Health Care Research Center, Nisshin Pharma Inc., 5-3-1, Fujimino, Saitama, 356-8511 Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Hiramoto
authors.affiliation: Health Care Research Center, Nisshin Pharma Inc., 5-3-1, Fujimino, Saitama, 356-8511 Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ikemoto
authors.affiliation: Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526 Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Nakata
authors.affiliation: Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526 Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Miyoshi
authors.affiliation: Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526 Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Isemura
authors.affiliation: Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526 Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Ohashi
authors.affiliation: Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526 Japan.
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Imai
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects*; D016207:Cytokines / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000188:drug therapy; D004195:Disease Models, Animal; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007376:Interleukin-2 / Q000096:biosynthesis; D019169:Jurkat Cells; D008027:Light; D020935:MAP Kinase Signaling System / Q000187:drug effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects*; D013025:Glycine max / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D018836:Inflammation Mediators; D007376:Interleukin-2; D010936:Plant Extracts
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