title: Melatonin in children with autism spectrum disorders: endogenous and pharmacokinetic profiles in relation to sleep.
abstract: Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melatonin profiles in relation to sleep in nine children with ASD. In endogenous samples, maximal melatonin concentration (C(max)) and time to peak concentration (T(max)) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children. In treatment samples (supplemental melatonin), melatonin parameters were also comparable to those previously published for typically developing children. Our findings support that children with ASD and insomnia responsive to low dose melatonin treatment have relatively normal profiles of endogenous and supplemental melatonin.
authors.affiliation: Departments of Neurology and Pediatrics Burry Chair in Cognitive Childhood Development, Sleep Disorders Division, Vanderbilt University Medical Center, 1161 21st Avenue South, Room A-0116, Nashville, TN, 37232-2551, USA.
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: Goldman
authors.forename: Karen W
authors.initials: KW
authors.lastname: Adkins
authors.forename: M Wade
authors.initials: MW
authors.lastname: Calcutt
authors.forename: Melissa D
authors.initials: MD
authors.lastname: Carter
authors.forename: Robert L
authors.initials: RL
authors.lastname: Goodpaster
authors.forename: Lily
authors.initials: L
authors.lastname: Wang
authors.forename: Yaping
authors.initials: Y
authors.lastname: Shi
authors.forename: Helen J
authors.initials: HJ
authors.lastname: Burgess
authors.forename: David L
authors.initials: DL
authors.lastname: Hachey
authors.forename: Beth A
authors.initials: BA
authors.lastname: Malow
mesh_terms: D002648:Child; D002659:Child Development Disorders, Pervasive / Q000097:blood* / Q000188:drug therapy; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000008:administration & dosage* / Q000097:blood*; D017286:Polysomnography / Q000379:methods; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D007319:Sleep Initiation and Maintenance Disorders / Q000097:blood* / Q000188:drug therapy
chemical_list: D008550:Melatonin
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