title: Lower risk for serious adverse events and no increased risk for cancer after PBSC vs BM donation.
abstract: We compared serious early and late events experienced by 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors who underwent collection of PBSC or BM between 2004 and 2009 as part of a prospective study through the National Marrow Donor Program. Standardized FDA definitions for serious adverse events (SAEs) were used, and all events were reviewed by an independent physician panel. BM donors had an increased risk for SAEs (2.38% for BM vs 0.56% for PBSC; odds ratio [OR], 4.13; P < .001), and women were twice as likely to experience an SAE (OR for men, 0.50; P = .005). Restricting the analysis to life-threatening, unexpected, or chronic/disabling events, BM donors maintained an increased risk for SAEs (0.99% for BM vs 0.31% for PBSC; OR, 3.20; P < .001). Notably, the incidence of cancer, autoimmune illness, and thrombosis after donation was similar in BM vs PBSC donors. In addition, cancer incidence in PBSC donors was less than that reported in the general population (Surveillance, Epidemiology, and End Results Program database). In conclusion, SAEs after donation are rare but more often occurred in BM donors and women. In addition, there was no evidence of increased risk for cancer, autoimmune illness, and stroke in donors receiving granulocyte colony-stimulating factor during this period of observation.
authors.affiliation: University of Utah School of Medicine, Primary Children's Hospital, Salt Lake City, UT;
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pulsipher
authors.affiliation: Center for International Blood and Marrow Transplant Research, Minneapolis, MN;
authors.forename: Pintip
authors.initials: P
authors.lastname: Chitphakdithai
authors.affiliation: Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;
authors.forename: Brent R
authors.initials: BR
authors.lastname: Logan
authors.affiliation: Center for International Blood and Marrow Transplant Research, Minneapolis, MN; National Marrow Donor Program, Minneapolis, MN;
authors.forename: Willis H
authors.initials: WH
authors.lastname: Navarro
authors.affiliation: The University of Michigan, Ann Arbor, MI;
authors.forename: John E
authors.initials: JE
authors.lastname: Levine
authors.affiliation: National Marrow Donor Program, Minneapolis, MN;
authors.forename: John P
authors.initials: JP
authors.lastname: Miller
authors.affiliation: Anthony Nolan Research Institute, London, United Kingdom;
authors.forename: Bronwen E
authors.initials: BE
authors.lastname: Shaw
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA; and.
authors.forename: Paul V
authors.initials: PV
authors.lastname: O'Donnell
authors.affiliation: Center for International Blood and Marrow Transplant Research, Minneapolis, MN; Cleveland Clinic, Cleveland, OH.
authors.forename: Navneet S
authors.initials: NS
authors.lastname: Majhail
authors.affiliation: Center for International Blood and Marrow Transplant Research, Minneapolis, MN; National Marrow Donor Program, Minneapolis, MN;
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Confer
mesh_terms: D000293:Adolescent; D000328:Adult; D001853:Bone Marrow; D016026:Bone Marrow Transplantation; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects; D006412:Hematopoietic Stem Cells; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D036102:Peripheral Blood Stem Cell Transplantation; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D012720:Severity of Illness Index; D014019:Tissue Donors / Q000706:statistics & numerical data; D020858:Tissue and Organ Harvesting / Q000009:adverse effects* / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D016179:Granulocyte Colony-Stimulating Factor
references.citation: Blood. 2009 Oct 29;114(18):3757-63
references.pmid: 19666868
references.citation: Blood. 1984 Sep;64(3):630-4
references.pmid: 6380620
references.citation: Blood. 2009 Apr 9;113(15):3604-11
references.pmid: 19190248
references.citation: Bone Marrow Transplant. 2010 May;45(5):832-8
references.pmid: 20173787
references.citation: Blood. 2013 Jan 3;121(1):197-206
references.pmid: 23109243
references.citation: Int J Hematol. 2010 Dec;92(5):765-8
references.pmid: 21120643
references.citation: Bone Marrow Transplant. 2011 Sep;46(9):1240-4
references.pmid: 21170092
references.citation: Bone Marrow Transplant. 2004 Jan;33(2):171-6
references.pmid: 14647251
references.citation: Blood. 1993 Apr 1;81(7):1940-6
references.pmid: 8461478
references.citation: Bone Marrow Transplant. 2004 Mar;33(6):661-5
references.pmid: 14716337
references.citation: Br J Haematol. 2006 Dec;135(5):642-50
references.pmid: 17054431
references.citation: Exp Hematol. 1996 Jun;24(7):839-47
references.pmid: 8647235
references.citation: Blood. 2011 Sep 1;118(9):2602-8
references.pmid: 21719598
references.citation: Bone Marrow Transplant. 2007 Aug;40(3):185-92
references.pmid: 17563736
references.citation: Haematologica. 2008 May;93(5):735-40
references.pmid: 18387976
references.citation: Bone Marrow Transplant. 2011 Jan;46(1):10-3
references.pmid: 20190845
references.citation: Blood. 1997 Aug 1;90(3):903-8
references.pmid: 9242518
references.citation: Bone Marrow Transplant. 2014 Feb;49(2):195-200
references.pmid: 24076552
references.citation: Bone Marrow Transplant. 2002 Nov;30(10):661-3
references.pmid: 12420204
references.citation: Biol Blood Marrow Transplant. 2014 Jan;20(1):118-27
references.pmid: 24184336
references.citation: Biol Blood Marrow Transplant. 2008 Sep;14(9 Suppl):29-36
references.pmid: 18721778
references.citation: Bone Marrow Transplant. 2000 Jan;25(1):85-9
references.pmid: 10654020
references.citation: Bone Marrow Transplant. 2001 Apr;27(7):689-92
references.pmid: 11360107
references.citation: Exp Hematol. 2004 Jan;32(1):122-30
references.pmid: 14725909
references.citation: Haematologica. 2009 Jan;94(1):94-101
references.pmid: 19059940
references.citation: J Natl Cancer Inst. 2007 Feb 7;99(3):196-205
references.pmid: 17284714
references.citation: Bone Marrow Transplant. 1996 Mar;17(3):433-4
references.pmid: 8704701
references.citation: Am J Hematol. 2003 Feb;72(2):82-93
references.pmid: 12555210