title: Sol-gel hybrid methyltrimethoxysilane-tetraethoxysilane as a new dispersive solid-phase extraction material for acrylamide determination in food with direct gas chromatography-mass spectrometry analysis.
abstract: A sol-gel hybrid sorbent, methyltrimethoxysilane-tetraethoxysilane (MTMOS-TEOS) was successfully used as new dispersive solid phase extraction (dSPE) sorbent material in the determination of acrylamide in several Sudanese foods and analysis using GC-MS. Several important dSPE parameters were optimised. Under the optimised conditions, excellent linearity (r(2)>0.9998) was achieved using matrix matched standard calibration in the concentration range 50-1000 μg kg(-1). The limits of detection (LOD) and limit of quantification ranged from 9.1 to 12.8 μg/kg and 27.8-38.9 μg/kg, respectively. The precision (RSD%) of the method was ⩽6.6% and recoveries of acrylamide obtained were in the range of 88-103%, (n=3). The LOD obtained is comparable with the LODs of primary secondary amine dSPE. The proposed MTMOS-TEOS dSPE method is direct and safe for acrylamide analysis, showed reliable method validation performances and good cleanup effects. It was successfully applied to the analysis of acrylamide in real food samples.
authors.affiliation: Separation Science and Technology Group (SepSTec), Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia; Department of Chemistry, Faculty of Science, University of Khartoum, Khartoum, Sudan; Central Laboratory, Ministry of Sciences & Technology, P.O. Box Office 7099, Khartoum, Sudan.
authors.forename: Mei Musa Ali
authors.initials: MM
authors.lastname: Omar
authors.affiliation: Separation Science and Technology Group (SepSTec), Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia; Nanotechnology Research Alliance, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia. Electronic address: waini@utm.my.
authors.forename: Wan Aini
authors.initials: WA
authors.lastname: Wan Ibrahim
authors.affiliation: Department of Chemistry, Faculty of Science, University of Khartoum, Khartoum, Sudan.
authors.forename: Abdalla Ahmed
authors.initials: AA
authors.lastname: Elbashir
mesh_terms: D020106:Acrylamide / Q000032:analysis*; D000327:Adsorption; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D005782:Gels / Q000737:chemistry; D057230:Limit of Detection; D019904:Polymethyl Methacrylate; D012821:Silanes / Q000737:chemistry; D052616:Solid Phase Extraction / Q000295:instrumentation / Q000379:methods*
chemical_list: D005782:Gels; D012821:Silanes; C071718:methyltrimethoxysilane; D020106:Acrylamide; C040733:tetraethoxysilane; D019904:Polymethyl Methacrylate
keywords: Acrylamide; Dispersive solid phase extraction; Gas chromatography–mass spectrometry; Sample preparation; Sol–gel hybrid