title: [Expression of SOX11 transcription factor. Its implication in mantle cell lymphoma].
abstract: SOX11, belonging to the family of genes SOXC, is a transcript factor involved in the embryonic neurogenesis and tissue remodeling, also participating in the control of cell proliferation. Its role in lymphomagenesis still remains unknown. Recent studies have shown aberrant SOX11 nuclear protein expression as well as mRNA levels in patients with mantle cell lymphoma (MCL). Although the majority of these lymphomas have an aggressive clinical course, there is a subgroup of patients with an indolent clinical evolution, suggesting a greater heterogeneity of this disease. Currently, there are contradictions regarding the association of SOX11 gene expression and outcome in MCL, while some authors have related the lack of SOX11 expression with good prognosis, others find it associated with an adverse clinical course. This difference in the gene expression could be associated to epigenetic mechanisms such as modifications at the histone level and DNA methylation that would allow the aberrant expression of this gene in some lymphoid neoplasias, including LCM. More knowledge of gene SOX11 in LCM will lead to a greater understanding of those mechanisms involved in the pathogenesis and progression of this lymphoma, also the involvement of SOX11 in these processes.
authors.affiliation: Laboratorio de Genética de Neoplasias Linfoides; Instituto de Medicina Experimental, CONICET - Academia Nacional de Medicina de Buenos Aires, Argentina.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Roisman
authors.forename: Irma
authors.initials: I
authors.lastname: Slavutsky
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000235:genetics*; D055751:SOXC Transcription Factors / Q000235:genetics* / Q000502:physiology
chemical_list: D014408:Biomarkers, Tumor; C097473:SOX11 protein, human; D055751:SOXC Transcription Factors
keywords: SOX11 gene; epigenetics; gene expression; mantle cell lymphoma