title: Cardenolides from the bark of Calotropis gigantea.
abstract: Three new cardenolides (1-3) were isolated from the 90% ethanolic extract of the bark of a wild-type Calotropis gigantea. Their structures were determined by using NMR spectra and LC-MS analysis. Their inhibitory activities were evaluated against non-small cell lung carcinoma (A549) and human cervix epithelial adenocarcinoma (HeLa) cell lines. Compounds 1 and 3 exhibited strong inhibitory effect on two cancer cell lines.
authors.affiliation: a Shanghai Key Laboratory of New Drug Design , School of Pharmacy, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237 , P.R. China.
authors.forename: Pham
authors.initials: P
authors.lastname: Van Khang
authors.forename: Zhong-Guo
authors.initials: ZG
authors.lastname: Zhang
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Meng
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Hu
authors.forename: Lei
authors.initials: L
authors.lastname: Ma
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031107:Calotropis / Q000737:chemistry*; D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006367:HeLa Cells; D006801:Humans; D014744:Vietnam
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides
keywords: A459; Asclepiadaceae; Calotropis gigantea; HeLa; cardenolide