title: Effect of a chitosan sponge impregnated with platelet-derived growth factor on bone augmentation beyond the skeletal envelope in rat calvaria.
abstract: We evaluated the ability of platelet-derived growth factor (PDGF) to promote bone augmentation beyond the skeletal envelope in rat calvaria. The calvariae of 14 rats were exposed, and two plastic caps-one with 0.03% PDGF and a chitosan sponge and one with a chitosan sponge alone-were placed. Microcomputed tomography and histologic sections were used to determine the amount of bone augmentation within the plastic caps. Bone volume was calculated using measurement software. Bone volume and amount of bone augmentation were significantly greater in the PDGF group than in the control group. In conclusion, a chitosan sponge containing 0.03% PDGF enhanced bone formation beyond the skeletal envelope in rat calvaria.
authors.affiliation: Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry.
authors.forename: Noriko
authors.initials: N
authors.lastname: Tsuchiya
authors.forename: Shuichi
authors.initials: S
authors.lastname: Sato
authors.forename: Risa
authors.initials: R
authors.lastname: Kigami
authors.forename: Eisuke
authors.initials: E
authors.lastname: Kawano
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takane
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Arai
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
authors.forename: Bunnai
authors.initials: B
authors.lastname: Ogiso
mesh_terms: D000818:Animals; D001846:Bone Development; D048271:Chitosan / Q000008:administration & dosage*; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D010982:Platelet-Derived Growth Factor; D048271:Chitosan