title: Cellular transcriptome analysis reveals differential expression of pro- and antiapoptosis genes by varicella-zoster virus-infected neurons and fibroblasts.
abstract: Transcriptional changes following varicella-zoster virus (VZV) infection of cultured human neurons derived from embryonic stem cells were compared to those in VZV-infected human foreskin fibroblasts. Transcription of 340 neuronal genes significantly altered by VZV infection included 223 transcript changes unique to neurons. Strikingly, genes inhibiting apoptosis were upregulated in neurons, while proapoptotic gene transcription was increased in fibroblasts. These data are a basis for discovery of differences in virus-host interactions between these VZV targets.
authors.affiliation: Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Amos
authors.initials: A
authors.lastname: Markus
authors.affiliation: Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Hiba
authors.initials: H
authors.lastname: Waldman Ben-Asher
authors.affiliation: Departments of Ophthalmology, Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Kinchington
authors.affiliation: Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel ron.goldstein@biu.ac.il.
authors.forename: Ronald S
authors.initials: RS
authors.lastname: Goldstein
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D015415:Biomarkers / Q000378:metabolism*; D002478:Cells, Cultured; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism* / Q000821:virology; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism* / Q000821:virology; D020869:Gene Expression Profiling; D014645:Herpesvirus 3, Human / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000378:metabolism* / Q000821:virology; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D015415:Biomarkers
references.citation: J Virol. 2014 May;88(9):5079-86
references.pmid: 24574392
references.citation: J Virol. 2012 Mar;86(6):3143-51
references.pmid: 22238304
references.citation: Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):600-5
references.pmid: 22190485
references.citation: Viruses. 2012 Sep;4(9):1509-14
references.pmid: 23170169
references.citation: J Neuroimmune Pharmacol. 2010 Sep;5(3):418-27
references.pmid: 20401540
references.citation: Brain Res. 2008 Sep 16;1230:50-60
references.pmid: 18671952
references.citation: J Virol. 2006 Jun;80(11):5113-24
references.pmid: 16698992
references.citation: J Virol. 2003 Jan;77(2):1268-80
references.pmid: 12502844
references.citation: Virology. 2013 Sep 1;443(2):285-93
references.pmid: 23769240
references.citation: J Virol. 2003 Dec;77(23):12852-64
references.pmid: 14610206
references.citation: Antiviral Res. 2005 Nov;68(2):56-65
references.pmid: 16118026
references.citation: J Virol. 2011 Jul;85(13):6220-33
references.pmid: 21525353
references.citation: PLoS Pathog. 2014 Jan 30;10(1):e1003896
references.pmid: 24497829
references.citation: J Virol. 2014 Jan;88(2):1381-8
references.pmid: 24227856
references.citation: J Virol. 2006 Jan;80(2):1025-31
references.pmid: 16379003