title: Identification of novel anelloviruses with broad diversity in UK rodents.
abstract: Anelloviruses are a family of small circular ssDNA viruses with a vast genetic diversity. Human infections with the prototype anellovirus, torque teno virus (TTV), are ubiquitous and related viruses have been described in a number of other mammalian hosts. Despite over 15 years of investigation, there is still little known about the pathogenesis and possible disease associations of anellovirus infections, arising in part due to the lack of a robust cell culture system for viral replication or tractable small-animal model. We report the identification of diverse anelloviruses in several species of wild rodents. The viruses are highly prevalent in wood mice (Apodemus sylvaticus) and field voles (Microtus agrestis), detectable at a low frequency in bank voles (Myodes glareolus), but absent from house mice (Mus musculus). The viruses identified have a genomic organization consistent with other anelloviruses, but form two clear phylogenetic groups that are as distinct from each other as from defined genera.
authors.affiliation: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK.
authors.forename: Shoko
authors.initials: S
authors.lastname: Nishiyama
authors.affiliation: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK.
authors.forename: Bernadette M
authors.initials: BM
authors.lastname: Dutia
authors.affiliation: Department of Infection Biology, University of Liverpool, Liverpool Science Park, 146 Brownlow Hill, Liverpool L3 5RF, UK.
authors.forename: James P
authors.initials: JP
authors.lastname: Stewart
authors.affiliation: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Meredith
authors.affiliation: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK.
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Shaw
authors.affiliation: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Simmonds
authors.affiliation: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK.
authors.forename: Colin P
authors.initials: CP
authors.lastname: Sharp
mesh_terms: D049811:Anelloviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D000818:Animals; D003411:Arvicolinae / Q000821:virology*; D016000:Cluster Analysis; D004266:DNA Virus Infections / Q000662:veterinary* / Q000821:virology; D014644:Genetic Variation; D051379:Mice; D008969:Molecular Sequence Data; D051189:Murinae / Q000821:virology*; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D006113:United Kingdom
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