title: Safety and efficacy of preoperative autologous blood donation for high-risk pregnant women: experience of a large university hospital in Japan.
abstract: OBJECTIVE
  Preoperative autologous blood donation (PAD) has the advantages over allogeneic blood transfusion of theoretically no risk of viral infection and alloimmunization. However, there are some concerns regarding PAD in pregnant women, as they sometimes become anemic and adverse effects such as low blood pressure could be harmful to fetuses. In our hospital, the PAD program was implemented in 2006 and has been used in pregnant women at high risk of massive hemorrhage. In this study, the safety of PAD in pregnant women and its efficacy for avoiding allogeneic blood transfusion were investigated.
  
  
  METHODS
  The hospital records of pregnant women who delivered at our hospital from January 2009 to June 2012 were reviewed and those who were enrolled in the PAD program for predicted massive hemorrhage were analyzed.
  
  
  RESULTS
  Among the total of 3095 deliveries, 69 cases enrolled in the PAD program were analyzed. Blood donation was performed 189 times for the 69 cases. The median donated blood volume was 1200 mL (range, 400-2000). The mean blood loss during delivery was 1976 ± 1654 mL. Autologous blood was transfused in 64 cases. Allogeneic blood transfusion was required in five cases of massive blood loss exceeding 5000 mL. In the other 64 cases, no additional allogeneic blood transfusion was required. No adverse events were observed in either the pregnant women or fetuses.
  
  
  CONCLUSIONS
  For pregnant women at a high risk of massive hemorrhage, our PAD program was safe and effective for avoiding allogeneic blood transfusion.
authors.affiliation: Department of Obstetrics and Gynecology, The University of Tokyo Hospital, Tokyo, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamashita
authors.forename: Nelson Hirokazu
authors.initials: NH
authors.lastname: Tsuno
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagamatsu
authors.forename: Naoko
authors.initials: N
authors.lastname: Okochi
authors.forename: Hironobu
authors.initials: H
authors.lastname: Hyodo
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ikeda
authors.forename: Michiru
authors.initials: M
authors.lastname: Kawabata
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Kamei
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nagura
authors.forename: Shinji
authors.initials: S
authors.lastname: Sone
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Fujii
authors.forename: Koki
authors.initials: K
authors.lastname: Takahashi
authors.forename: Shiro
authors.initials: S
authors.lastname: Kozuma
mesh_terms: D001782:Blood Donors; D016063:Blood Loss, Surgical; D001804:Blood Transfusion, Autologous; D005260:Female; D006785:Hospitals, University; D006801:Humans; D011247:Pregnancy
keywords: allogeneic; autologous; hemorrhage; pregnancy; transfusion