title: A high sensitive biosensor based on FePt/CNTs nanocomposite/N-(4-hydroxyphenyl)-3,5-dinitrobenzamide modified carbon paste electrode for simultaneous determination of glutathione and piroxicam.
abstract: This study describes the development, electrochemical characterization and utilization of novel modified N-(4-hydroxyphenyl)-3,5-dinitrobenzamide-FePt/CNTs carbon paste electrode for the electrocatalytic determination of glutathione (GSH) in the presence of piroxicam (PXM) for the first time. The synthesized nanocomposite was characterized with different methods such as TEM and XRD. The modified electrode exhibited a potent and persistent electron mediating behavior followed by well-separated oxidation peaks of GSH and PXM. The peak currents were linearly dependent on GSH and PXM concentrations in the range of 0.004-340 and 0.5-550 µmol L(-1), with detection limits of 1.0 nmol L(-1) and 0.1 µmolL(-1), respectively. The modified electrode was successfully used for the determination of the analytes in real samples with satisfactory results.
authors.affiliation: Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran. Electronic address: h.karimi.maleh@gmail.com.
authors.forename: Hassan
authors.initials: H
authors.lastname: Karimi-Maleh
authors.affiliation: Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Tahernejad-Javazmi
authors.affiliation: Department of Chemistry, Isfahan University of Technology, Isfahan, Iran.
authors.forename: Ali A
authors.initials: AA
authors.lastname: Ensafi
authors.affiliation: Department of Physics, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Moradi
authors.affiliation: Department of Chemistry, Isfahan University of Technology, Isfahan, Iran.
authors.forename: Shadpour
authors.initials: S
authors.lastname: Mallakpour
authors.affiliation: Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Beitollahi
mesh_terms: D001549:Benzamides / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation*; D045424:Complex Mixtures / Q000032:analysis; D003217:Conductometry / Q000295:instrumentation*; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005978:Glutathione / Q000032:analysis*; D007501:Iron / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009824:Ointments; D010894:Piroxicam / Q000032:analysis*; D010984:Platinum / Q000737:chemistry
chemical_list: D001549:Benzamides; D045424:Complex Mixtures; D037742:Nanotubes, Carbon; D009824:Ointments; D010894:Piroxicam; D010984:Platinum; C008599:nitromide; D007501:Iron; D005978:Glutathione
keywords: Biosensor; FePt/CNTs; Glutathione; Piroxicam; Voltammetry