title: Exserolides A-F, new isocoumarin derivatives from the plant endophytic fungus Exserohilum sp.
abstract: Six new isocoumarin derivatives, exserolides A-F (1-6), were isolated from solid cultures of the plant endophytic fungus Exserohilum sp., together with four known metabolites (7-10). The structures of 1-6 were elucidated primarily by NMR experiments. The absolute configuration of the C-3 methine carbon in 1-5 was deduced via the circular dichroism data, whereas that of the 1,3-diol moiety in 6 was assigned from the (1)H NMR data of its (R)- and (S)-MTPA diesters. Compounds 3 and 9 showed antifungal activity against the plant pathogen Fusarium oxysporum, whereas 6 displayed significant inhibitory effects against a small panel of bacteria.
authors.affiliation: Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China; State Key Laboratory of Antitoxic Drugs & Toxicology, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, PR China.
authors.forename: Ruxin
authors.initials: R
authors.lastname: Li
authors.affiliation: State Key Laboratory of Antitoxic Drugs & Toxicology, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, PR China.
authors.forename: Shenxi
authors.initials: S
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Antitoxic Drugs & Toxicology, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, PR China.
authors.forename: Shubin
authors.initials: S
authors.lastname: Niu
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Liangdong
authors.initials: L
authors.lastname: Guo
authors.affiliation: Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: yinjun2002@yahoo.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Antitoxic Drugs & Toxicology, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, PR China. Electronic address: cheys@im.ac.cn.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D060026:Endophytes; D005670:Fusarium / Q000187:drug effects; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010944:Plants / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D049934:Isocoumarins
keywords: (12R)-12-hydroxymonocerin (PubChem CID: 24896700); (12S)-12-hydroxymonocerin (PubChem CID: 24896699); (–)-mellein (PubChem CID: 114679); 11-hydroxymonocerin (PubChem CID: 25111599); Antibacterial activity; Antifungal activity; Endophytic fungus; Exserohilum sp.; Isocoumarins; Lasionectrin (PubChem CID: 60155242); Monocerin (PubChem CID: 92267)