title: Recent research on the growth plate: Recent insights into the regulation of the growth plate.
abstract: For most bones, elongation is driven primarily by chondrogenesis at the growth plates. This process results from chondrocyte proliferation, hypertrophy, and extracellular matrix secretion, and it is carefully orchestrated by complex networks of local paracrine factors and modulated by endocrine factors. We review here recent advances in the understanding of growth plate physiology. These advances include new approaches to study expression patterns of large numbers of genes in the growth plate, using microdissection followed by microarray. This approach has been combined with genome-wide association studies to provide insights into the regulation of the human growth plate. We also review recent studies elucidating the roles of bone morphogenetic proteins, fibroblast growth factors, C-type natriuretic peptide, and suppressor of cytokine signaling in the local regulation of growth plate chondrogenesis and longitudinal bone growth.
authors.affiliation: Program in Developmental Endocrinology and GeneticsEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, CRC, Room 1-3330, 10 Center Drive, MSC 1103, Bethesda, Maryland 20892-1103, USACenter for Molecular Medicine and Pediatric Endocrinology UnitDepartment of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, SE-171 76 Stockholm, Sweden luichunk@mail.nih.gov.
authors.forename: Julian C
authors.initials: JC
authors.lastname: Lui
authors.affiliation: Program in Developmental Endocrinology and GeneticsEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, CRC, Room 1-3330, 10 Center Drive, MSC 1103, Bethesda, Maryland 20892-1103, USACenter for Molecular Medicine and Pediatric Endocrinology UnitDepartment of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, SE-171 76 Stockholm, SwedenProgram in Developmental Endocrinology and GeneticsEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, CRC, Room 1-3330, 10 Center Drive, MSC 1103, Bethesda, Maryland 20892-1103, USACenter for Molecular Medicine and Pediatric Endocrinology UnitDepartment of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
authors.forename: Ola
authors.initials: O
authors.lastname: Nilsson
authors.affiliation: Program in Developmental Endocrinology and GeneticsEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, CRC, Room 1-3330, 10 Center Drive, MSC 1103, Bethesda, Maryland 20892-1103, USACenter for Molecular Medicine and Pediatric Endocrinology UnitDepartment of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Baron
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000502:physiology; D020219:Chondrogenesis / Q000235:genetics / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D055106:Genome-Wide Association Study; D013006:Growth Hormone / Q000235:genetics / Q000502:physiology; D006132:Growth Plate / Q000166:cytology / Q000254:growth & development* / Q000502:physiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000502:physiology; D009154:Mutation; D020098:Natriuretic Peptide, C-Type / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics / Q000502:physiology
chemical_list: D019485:Bone Morphogenetic Proteins; D050826:Suppressor of Cytokine Signaling Proteins; D020098:Natriuretic Peptide, C-Type; D005346:Fibroblast Growth Factors; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
keywords: IGF; growth hormone; microarray; signal transduction; skeletal
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