title: Mitochondrial pathology in osteoarthritic chondrocytes.
abstract: Osteoarthritis (OA) is a chronic degenerative disease leading to aberrance of cartilage structures with unclear or multifactorial mechanisms. Recently, a great portion of research endeavor to explore the molecular mechanisms of OA in focusing on the mitochondrial pathology. Mitochondrial respiratory chain (MRC) produces reactive oxygen species (ROS), which in turn impair mtDNA integrity and link to cartilage degradation in OA. The fine-tuning between ROS and antioxidant within chondrocytes ensures cartilage homeostasis. With disturbance from pro-inflammatory cytokines, oxidative stress synergistically instigates cellular signaling and exacerbates mitochondrial pathology, which may affect several pathways implicated in OA cartilage degradation, including oxidative stress, increase of cytokine-induced chondrocytes inflammation and matrix catabolism, aging and senescence, obesity-related pathology, and cartilage matrix calcification. Unveiling the molecular mechanisms of mitochondrial function in OA pathogenesis and progression is essential for providing relevant therapeutic targets. These suggest that efficient protection and improvement of mitochondrial activity can be a therapeutic alternative for OA patients.
authors.forename: Longhuo
authors.initials: L
authors.lastname: Wu
authors.forename: Haiqing
authors.initials: H
authors.lastname: Liu
authors.forename: Linfu
authors.initials: L
authors.lastname: Li
authors.forename: Hai
authors.initials: H
authors.lastname: Liu
authors.forename: Qilai
authors.initials: Q
authors.lastname: Cheng
authors.forename: Hongliang
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China. longhwu@hotmail.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
mesh_terms: D000375:Aging / Q000378:metabolism / Q000473:pathology; D000975:Antioxidants / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002356:Cartilage / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D019902:Chondrocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D016207:Cytokines / Q000276:immunology; D006801:Humans; D008928:Mitochondria / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000473:pathology; D010003:Osteoarthritis / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016207:Cytokines; D017382:Reactive Oxygen Species; D002118:Calcium