title: Elevated plasma IL-37, IL-18, and IL-18BP concentrations in patients with acute coronary syndrome.
abstract: OBJECTIVE
  More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in the foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting that IL-37 is involved in atherosclerosis-related diseases. However, the plasma levels of IL-37 in patients with acute coronary syndrome (ACS, including unstable angina pectoris and acute myocardial infarction) have yet to be investigated.
  
  
  METHODS
  Plasma IL-37, IL-18, and IL-18BP levels were measured in 50 patients with stable angina pectoris (SAP), 75 patients with unstable angina pectoris (UAP), 67 patients with acute myocardial infarction (AMI), and 65 control patients.
  
  
  RESULTS
  The plasma IL-37, IL-18, and IL-18BP levels were significantly increased in ACS patients compared to SAP and control patients. A correlation analysis showed that the plasma biomarker levels were positively correlated with each other and with the levels of C-reactive protein (CRP), N-terminal probrain natriuretic peptide (NT-proBNP), and left ventricular end-diastolic dimension (LVEDD) but negatively correlated with left ventricular ejection fraction (LVEF). Furthermore, the plasma IL-37, IL-18, and IL-18BP had no correlation with the severity of the coronary artery stenosis.
  
  
  CONCLUSIONS
  The results indicate that the plasma IL-37 levels are associated with the onset of ACS.
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China ; Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Ji
authors.affiliation: Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Qiutang
authors.initials: Q
authors.lastname: Zeng
authors.affiliation: Department of Ultrasound, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Yingzhong
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Zhengde
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Meng
authors.affiliation: Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Bangwei
authors.initials: B
authors.lastname: Wu
authors.affiliation: Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Kunwu
authors.initials: K
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Chai
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Yujie
authors.identifier: 0000-0002-4874-0556
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000208:Acute Disease; D000368:Aged; D000787:Angina Pectoris / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D017023:Coronary Angiography; D015150:Echocardiography, Doppler; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D007375:Interleukin-1 / Q000097:blood*; D020382:Interleukin-18 / Q000097:blood*; D007963:Leukocytes, Mononuclear / Q000166:cytology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D016277:Ventricular Function, Left
chemical_list: C508587:IL37 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D007375:Interleukin-1; D020382:Interleukin-18; D010446:Peptide Fragments; C118370:interleukin-18 binding protein; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein
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