title: Amygdala Activation and Emotional Processing in Adolescents at Risk for Substance Use Disorders.
abstract: Studies are needed that examine neurobiological characteristics in high risk individuals prior to substance use disorder (SUD) development. In this pilot study, 4 adolescent subjects at high risk (having at least 1 parent with a SUD) for SUD were compared with 4 adolescent reference subjects on a corticolimbic reactivity paradigm, where they were presented with affect-laden faces or geometric shapes. FMRI was used to measure cortical activation in response to these stimuli. High risk subjects, compared to low risk, exhibited greater left amygdala activation (t=3.60, df=6, p=0.01), suggesting they may exhibit hyper-responsivity of the amygdala in response to emotional stimuli.
authors.affiliation: Department of Psychiatry, University of Pittsburgh, 3811 O'Hara St., Oxford Bldg. Suite 800, Pittsburgh, PA 15213.
authors.forename: Dawn L
authors.initials: DL
authors.lastname: Thatcher
authors.affiliation: Department of Psychiatry, University of Pittsburgh, 3811 O'Hara St., Oxford Bldg. Suite 800, Pittsburgh, PA 15213.
authors.forename: Stefan
authors.initials: S
authors.lastname: Pajtek
authors.affiliation: Department of Psychiatry, University of Pittsburgh, 3811 O'Hara St., Oxford Bldg. Suite 800, Pittsburgh, PA 15213 ; Center for Education and Drug Abuse Research, School of Pharmacy, University of Pittsburgh, 711 Salk Hall, Pittsburgh, PA 15261.
authors.forename: Ralph
authors.initials: R
authors.lastname: Tarter
authors.affiliation: Department of Psychiatry, University of Pittsburgh, 3811 O'Hara St., Oxford Bldg. Suite 800, Pittsburgh, PA 15213.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Long
authors.affiliation: Department of Psychiatry, University of Pittsburgh, 3811 O'Hara St., Oxford Bldg. Suite 800, Pittsburgh, PA 15213.
authors.forename: Duncan B
authors.initials: DB
authors.lastname: Clark
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