title: Effect of basic fibroblast growth factor on angiogenesis and bone regeneration in non-critical-size bone defects in rat calvaria.
abstract: We used microcomputed tomography (micro-CT) to evaluate the effects of basic fibroblast growth factor (FGF-2) contained in absorbable collagen sponges on angiogenesis and bone regeneration in rat calvarial non-critical-size bone defects. Two symmetrical non-critical-size calvarial bone defects (diameter, 2.7 mm) were created in male Fisher rats. An absorbable collagen sponge with or without FGF-2 (0.1% or 0.3%) was implanted into each defect. Blood vessel volume and bone volume were calculated using software. On day 28, blood vessel volume and bone volume were significantly greater in the 0.3% and 0.1% FGF-2 groups than in the control group. FGF-2 concentration-dependently increased blood vessels and bone formation in non-critical-size bone defects in rat calvaria.
authors.affiliation: Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry.
authors.forename: Risa
authors.initials: R
authors.lastname: Kigami
authors.forename: Shuichi
authors.initials: S
authors.lastname: Sato
authors.forename: Noriko
authors.initials: N
authors.lastname: Tsuchiya
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Sato
authors.forename: Daigo
authors.initials: D
authors.lastname: Suzuki
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Arai
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
authors.forename: Bunnai
authors.initials: B
authors.lastname: Ogiso
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D016222:Fibroblast Growth Factor 2 / Q000502:physiology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012886:Skull / Q000473:pathology*
chemical_list: D016222:Fibroblast Growth Factor 2