title: ADMA/SDMA in elderly subjects with asymptomatic carotid atherosclerosis: values and site-specific association.
abstract: Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase (NOS) inhibitor known as a mediator of endothelial dysfunction and atherosclerosis. Circulating ADMA levels are correlated with cardiovascular risk factors such as hypercholesterolemia, arterial hypertension, diabetes mellitus, hyperhomocysteinemia, age and smoking. We assessed the relationship between ADMA values and site-specific association of asymptomatic carotid atherosclerosis (intima-media thickness (CIMT) and plaque) in elderly subjects. One hundred and eighty subjects underwent a complete history and physical examination, determination of serum chemistries and ADMA levels, and carotid ultrasound investigation (CUI). All subjects had no acute or chronic symptoms of carotid atherosclerosis. Statistical analyses showed that high plasma levels of ADMA/SDMA were positively correlated to carotid atherosclerosis (CIMT and plaque) (p<0.001), with significant site-specific association. Total cholesterol, low density lipoprotein cholesterol, triglycerides and C-reactive protein plasma concentrations were significantly associated with asymptomatic carotid atherosclerosis (p<0.001). High serum concentrations of ADMA and SDMA were associated with carotid atherosclerotic lesions as measured by CIMT ad plaque and may represent a new marker of asymptomatic carotid atherosclerosis in elderly subjects.
authors.affiliation: Cardiology Unit, San Camillo de Lellis, "San Camillo De Lellis", Manfredonia, 71043 Foggia, Italy. griccioni@hotmail.com.
authors.forename: Graziano
authors.initials: G
authors.lastname: Riccioni
authors.affiliation: Department of Experimental and Clinical Science, University G. D'Annunzio, 61013 Chieti, Italy. Luca_Scotti@yahoo.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Scotti
authors.affiliation: Department of Experimental and Clinical Science, University G. D'Annunzio, 61013 Chieti, Italy. ndorazio@unich.it.
authors.forename: Nicolantonio
authors.initials: N
authors.lastname: D'Orazio
authors.affiliation: Department of Neuroscience and Imaging, University G. D'Annunzio, 61013 Chieti, Italy. s.gallina@unich.it.
authors.forename: Sabina
authors.initials: S
authors.lastname: Gallina
authors.affiliation: Cardiac Surgery Unit, Anthea Hospital, GVM Care & Research, 71024 Bari, Italy. g.speziale@libero.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Speziale
authors.affiliation: Department of Medicine and Science of Aging, University G. D'Annunzio, 66013 Chieti, Italy. l.speranza@unich.it.
authors.forename: Lorenza
authors.initials: L
authors.lastname: Speranza
authors.affiliation: Department of Experimental and Clinical Science, University G. D'Annunzio, 61013 Chieti, Italy. t.bucciarelli@dsb.unich.it.
authors.forename: Tonino
authors.initials: T
authors.lastname: Bucciarelli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002340:Carotid Artery Diseases / Q000097:blood* / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D014280:Triglycerides; C024917:symmetric dimethylarginine; C018524:N,N-dimethylarginine; D002097:C-Reactive Protein; D001120:Arginine; D002784:Cholesterol
references.citation: J Endocrinol Invest. 2012 Oct;35(9):824-7
references.pmid: 23135319
references.citation: Kidney Int. 2005 Nov;68(5):2230-6
references.pmid: 16221223
references.citation: Int J Mol Sci. 2012 Sep 26;13(10):12315-35
references.pmid: 23202900
references.citation: Hypertension. 2008 Dec;52(6):1051-9
references.pmid: 18852383
references.citation: Ann Med. 2006;38(2):126-36
references.pmid: 16581698
references.citation: Int J Mol Sci. 2012;13(6):7521-31
references.pmid: 22837709
references.citation: Anal Biochem. 2006 Jun 15;353(2):287-9
references.pmid: 16603118
references.citation: Eur Heart J. 2003 Nov;24(21):1912-9
references.pmid: 14585249
references.citation: Clin Exp Rheumatol. 2012 May-Jun;30(3):388-96
references.pmid: 22410121
references.citation: Int J Mol Sci. 2012 Nov 28;13(12):15983-6004
references.pmid: 23443106
references.citation: Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2536-40
references.pmid: 16931791
references.citation: Kidney Int. 2006 Jul;70(1):26-33
references.pmid: 16723985
references.citation: J Am Coll Cardiol. 2004 Apr 7;43(7):1177-84
references.pmid: 15063426
references.citation: Int J Mol Sci. 2013 Dec 16;14(12):24412-21
references.pmid: 24351825
references.citation: Circulation. 2001 Dec 4;104(23):2815-9
references.pmid: 11733400
references.citation: J Biol Regul Homeost Agents. 2010 Jul-Sep;24(3):351-8
references.pmid: 20846483
references.citation: Hypertens Res. 2008 Jun;31(6):1185-9
references.pmid: 18716367
references.citation: Eur Heart J. 2005 Sep;26(18):1846-51
references.pmid: 15860520
references.citation: Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1951-6
references.pmid: 15297277
references.citation: J Am Soc Nephrol. 2002 Feb;13(2):490-496
references.pmid: 11805179
references.citation: Atherosclerosis. 2007 Mar;191(1):206-10
references.pmid: 16672157
references.citation: Curr Cardiol Rev. 2010 May;6(2):82-90
references.pmid: 21532773
references.citation: Free Radic Biol Med. 2007 Nov 1;43(9):1255-62
references.pmid: 17893038
references.citation: J Am Coll Cardiol. 1997 Mar 1;29(3):479-85
references.pmid: 9060881
references.citation: Postgrad Med. 2013 Mar;125(2):108-23
references.pmid: 23816777