title: Characteristics, in-hospital and long-term clinical outcomes of nonagenarian compared with octogenarian acute myocardial infarction patients.
abstract: We compared clinical characteristics, management, and clinical outcomes of nonagenarian acute myocardial infarction (AMI) patients (n=270, 92.3 ± 2.3 yr old) with octogenarian AMI patients (n=2,145, 83.5 ± 2.7 yr old) enrolled in Korean AMI Registry (KAMIR). Nonagenarians were less likely to have hypertension, diabetes and less likely to be prescribed with beta-blockers, statins, and glycoprotein IIb/IIIa inhibitors compared with octogenarians. Although percutaneous coronary intervention (PCI) was preferred in octogenarians than nonagenarians, the success rate of PCI between the two groups was comparable. In-hospital mortality, the composite of in-hospital adverse outcomes and one year mortality were higher in nonagenarians than in octogenarians. However, the composite of the one year major adverse cardiac events (MACEs) was comparable between the two groups without differences in MI or re-PCI rate. PCI improved 1-yr mortality (adjusted hazard ratio [HR], 0.50; 95% confidence interval [CI], 0.36-0.69, P<0.001) and MACEs (adjusted HR, 0.47; 95% CI, 0.37-0.61, P<0.001) without significant complications both in nonagenarians and octogenarians. In conclusion, nonagenarians had similar 1-yr MACEs rates despite of higher in-hospital and 1-yr mortality compared with octogenarian AMI patients. PCI in nonagenarian AMI patients was associated to better 1-yr clinical outcomes.
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Ki Hong
authors.identifier: 0000-0002-9938-3464
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Youngkeun
authors.identifier: 0000-0003-2022-9366
authors.initials: Y
authors.lastname: Ahn
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Sung Soo
authors.identifier: 0000-0002-5190-227X
authors.initials: SS
authors.lastname: Kim
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Si Hyun
authors.identifier: 0000-0001-8376-5946
authors.initials: SH
authors.lastname: Rhew
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Young Wook
authors.identifier: 0000-0001-8863-0071
authors.initials: YW
authors.lastname: Jeong
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Soo Young
authors.identifier: 0000-0001-5843-0802
authors.initials: SY
authors.lastname: Jang
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Jae Yeong
authors.identifier: 0000-0002-9393-2821
authors.initials: JY
authors.lastname: Cho
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Hae Chang
authors.identifier: 0000-0002-1273-3864
authors.initials: HC
authors.lastname: Jeong
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Keun-Ho
authors.initials: KH
authors.lastname: Park
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Nam Sik
authors.initials: NS
authors.lastname: Yoon
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Doo Sun
authors.initials: DS
authors.lastname: Sim
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Hyun Joo
authors.identifier: 0000-0003-1285-3660
authors.initials: HJ
authors.lastname: Yoon
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Kye Hun
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Young Joon
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Hyung Wook
authors.initials: HW
authors.lastname: Park
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Ju Han
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Jeong Gwan
authors.initials: JG
authors.lastname: Cho
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Jong Chun
authors.identifier: 0000-0002-3168-2054
authors.initials: JC
authors.lastname: Park
authors.affiliation: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Myung Ho
authors.identifier: 0000-0003-4173-1494
authors.initials: MH
authors.lastname: Jeong
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungbuk National University, Chungju, Korea.
authors.forename: Myeong-Chan
authors.identifier: 0000-0002-0047-0227
authors.initials: MC
authors.lastname: Cho
authors.affiliation: Department of Cardiovascular Medicine, East West Neo Medical Center, Seoul, Korea.
authors.forename: Chong Jin
authors.initials: CJ
authors.lastname: Kim
authors.affiliation: Department of Cardiovascular Medicine, Yeungnam University Hospital, Daegu, Korea.
authors.forename: Young Jo
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D004562:Electrocardiography; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D062645:Percutaneous Coronary Intervention; D016016:Proportional Hazards Models; D012042:Registries; D016896:Treatment Outcome
keywords: Aged, Eighty and over; Myocardial Infarction; Percutaneous Coronary Intervention
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