title: The first caprine rotavirus detected in Argentina displays genomic features resembling virus strains infecting members of the Bovidae and Camelidae.
abstract: Rotavirus group A (RVA) is a major cause of diarrhea in humans and young animals including small ruminants. The purpose of this study was to identify RVA in dairy goat kids, and to characterize the complete genomic constellation and genetic relatedness with other RVA strains. Four out of twenty fecal samples from diarrheic and non-diarrheic goat kids were positive for RVA by ELISA. A representative sample was selected for further genome analyses. The RVA strain RVA/Goat-wt/ARG/0040/2011/G8P[1] displayed the following genomic constellation: G8-P[1]-I2-R5-C2-M2-A3-N2-T6-E12-H3, reminiscent to guanaco and other bovine-like RVA strains detected in Argentina. Phylogenetic analyses revealed that most of the genome segments had a rather close relatedness with RVA strains typically obtained from cattle, sheep, South American camelids and goats. Interestingly, strain 0040 possessed the R5 and E12 genotypes which have up to date only been found in different animal species from Argentina. Overall, these findings suggest that strain 0040 could represent a typical goat RVA genome constellation similar to those previously found in other animal species within the order Artiodactyla.
authors.affiliation: Grupo de Sanidad Animal, Área de Producción Animal, EEA INTA Balcarce, Ruta 226 km 73.5, 7620 Balcarce, Buenos Aires, Argentina.
authors.forename: Enrique L
authors.initials: EL
authors.lastname: Louge Uriarte
authors.affiliation: Laboratorio de Virus Entéricos, Instituto de Virología, CICVyA INTA-Castelar, CC 25, 1712 Hurlingham, Buenos Aires, Argentina.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Badaracco
authors.affiliation: Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
authors.forename: Jelle
authors.initials: J
authors.lastname: Matthijnssens
authors.affiliation: Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
authors.forename: Mark
authors.initials: M
authors.lastname: Zeller
authors.affiliation: Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Heylen
authors.affiliation: Grupo de Sanidad Animal, Área de Producción Animal, EEA INTA Balcarce, Ruta 226 km 73.5, 7620 Balcarce, Buenos Aires, Argentina.
authors.forename: Jorge
authors.initials: J
authors.lastname: Manazza
authors.affiliation: Laboratorio de Virus Entéricos, Instituto de Virología, CICVyA INTA-Castelar, CC 25, 1712 Hurlingham, Buenos Aires, Argentina.
authors.forename: Samuel
authors.initials: S
authors.lastname: Miño
authors.affiliation: Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: Van Ranst
authors.affiliation: Grupo de Sanidad Animal, Área de Producción Animal, EEA INTA Balcarce, Ruta 226 km 73.5, 7620 Balcarce, Buenos Aires, Argentina.
authors.forename: Anselmo
authors.initials: A
authors.lastname: Odeón
authors.affiliation: Laboratorio de Virus Entéricos, Instituto de Virología, CICVyA INTA-Castelar, CC 25, 1712 Hurlingham, Buenos Aires, Argentina. Electronic address: vparreno@cnia.inta.gov.ar.
authors.forename: Viviana
authors.initials: V
authors.lastname: Parreño
mesh_terms: D000818:Animals; D001118:Argentina; D016679:Genome, Viral / Q000235:genetics*; D023281:Genomics; D005838:Genotype; D015511:Goat Diseases / Q000821:virology*; D006041:Goats; D008969:Molecular Sequence Data; D010802:Phylogeny; D012401:Rotavirus / Q000145:classification* / Q000235:genetics*; D012400:Rotavirus Infections / Q000662:veterinary* / Q000821:virology
keywords: Argentina; G8P[1]; Goat; Rotavirus