title: Pretreatment with buthionine sulfoximine enhanced uptake and retention of BSH in brain tumor.
abstract: To determine the influence of buthionine sulfoximine (BSO) on boron biodistribution after sulfhydryl borane (BSH) administration for boron neutron capture therapy, the effectiveness of the combination of BSO with sulfhydril- (BSH) and non-sulfhydril (B12H12 and BNH3) boron compounds, and the interval between BSO and BSH administration, the retention of boron in tissues have been evaluated using a 9L rat tumor model. Simultaneous administration of BSH and BSO showed significantly higher boron accumulation compared to that without BSO, however there was no difference in tissue boron level between B12H12 and BNH3 administration with BSO or without BSO. The longer interval (6h) between BSH and BSO administration related to the highest boron concentration in the brain and subcutaneous tumors compared to shorter intervals (0.5, 3h). Boron concentration in subcutaneous and brain tumors was maintained for 6 and 12h after the administration of BSH following BSO pretreatment.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Yoshida
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan. Electronic address: yamamoto_neurosurg@md.tsukuba.ac.jp.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakai
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Zaboronok
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Akutsu
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Ishikawa
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shirakawa
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Matsumura
mesh_terms: D000818:Animals; D001894:Borohydrides / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000532:radiotherapy; D019328:Buthionine Sulfoximine / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004357:Drug Synergism; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009928:Organ Specificity / Q000187:drug effects; D011292:Premedication / Q000379:methods*; D051381:Rats; D011916:Rats, Inbred F344; D013438:Sulfhydryl Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D001894:Borohydrides; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; D019328:Buthionine Sulfoximine
keywords: Buthionine sulfoximine; Neutron capture therapy; Sulfhydryl borane