title: Prognosis associated with surgery for non-small cell lung cancer and synchronous brain metastasis.
abstract: OBJECTIVE
  Several reports have described extended survival after aggressive surgical treatment for non-small cell lung cancer (NSCLC) and synchronous brain metastasis. This retrospective analysis assesses the prognostic factors in this population.
  
  
  METHODS
  We reviewed retrospectively the medical records of 29 patients with synchronous brain metastasis from NSCLC, who underwent surgical treatment in our institution between 1980 and 2008. All patients underwent chest surgery to remove the primary lesion. The impact of several variables on survival was assessed.
  
  
  RESULTS
  The median follow-up period was 9.6 months and the 5-year survival rate from the time of lung cancer resection was 20.6 %. Univariate analysis demonstrated that the carcinoembryonic antigen (CEA) level, primary tumor size, and the presence of lymph node involvement were predictive of overall survival (p < 0.05). Multivariate analysis also identified those factors to be independent favorable prognostic factors.
  
  
  CONCLUSIONS
  Although the survival of patients with brain metastasis from non-small cell lung cancer remains poor, surgical resection may benefit a select group of patients, particularly those with a normal CEA level, small tumor size, and node-negative status.
authors.affiliation: Department of General Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3 Nakamichi 1-chome, Higashinari-ku, Osaka, 537-8511, Japan, kanoutakashi0999@yahoo.co.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanou
authors.forename: Jiro
authors.initials: J
authors.lastname: Okami
authors.forename: Toshiteru
authors.initials: T
authors.lastname: Tokunaga
authors.forename: Ayako
authors.initials: A
authors.lastname: Fujiwara
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ishida
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kuno
authors.forename: Masahiko
authors.initials: M
authors.lastname: Higashiyama
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001932:Brain Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D002272:Carcinoembryonic Antigen / Q000097:blood; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D018579:Patient Selection; D011013:Pneumonectomy; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen
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