title: Charged polymer brushes-grafted hollow silica nanoparticles as a novel promising material for simultaneous joint lubrication and treatment.
abstract: The fabrication of core/shell charged polymer brushes-grafted hollow silica nanoparticles (PSPMA-g-HSNPs) is reported. Because of the excellent hydration capability of the shells consisting of charged polymer brushes, the functional nanoparticles can achieve a good lubricating effect in aqueous media via hydration lubrication mechanism. The mesoporous hollow silica cores endow the nanoparticles with drug loading-release capability. Aspirin, as a useful drug for treating arthritis, was employed to carry out in vitro drug loading and release studies. It is clear that brushes-modified hollow silica exhibited long-term drug release performance. The combination of lubrication and drug loading capabilities results in the great clinical potential of new multifunctional nanoparticles as injectable joint lubricant fluid in arthritis treatment.
authors.affiliation: State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, Gansu, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Liu
authors.forename: Meirong
authors.initials: M
authors.lastname: Cai
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.forename: Weimin
authors.initials: W
authors.lastname: Liu
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001168:Arthritis / Q000188:drug therapy; D001241:Aspirin / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D054327:Lubricants / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012212:Rheology; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D054327:Lubricants; D011108:Polymers; D012822:Silicon Dioxide; D001241:Aspirin