title: Soy lipophilic protein nanoparticles as a novel delivery vehicle for conjugated linoleic acid.
abstract: Soy lipophilic protein nanoparticles (LPP), which present a novel delivery vehicle for conjugated linoleic acid (CLA), were fabricated by ultrasonication of the soy lipophilic protein (LP), which exhibits unique characteristics including a high loading capacity, oxidation protection and a sustained releasing profile in vitro for CLA. The CLA-loaded LPP exhibited a mean diameter of 170 ± 0.63 nm and a loading capacity of 26.3 ± 0.40% (w/w). A coating of sodium caseinate (SC) on the surface improved the colloidal stability of the CLA-loaded LPP. This encapsulation conferred protection against the oxidation of CLA, by which the head space-oxygen consumption and hydrogen peroxide value were obviously decreased in comparison with the SC-encapsulated CLA and CLA alone. The delivery system enables a sustained releasing profile of CLA in a simulated gastrointestinal tract (GIT). These findings illustrate that the LPP could act as an effective delivery device for CLA, which could provide oxidation stability and a sustained release property.
authors.affiliation: Research and Development Centre of Food Proteins, Department of Food Science and Technology, South China University of Technology, Guangzhou 510640, People's Republic of China. fexqyang@scut.edu.cn.
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Gao
authors.forename: Le-Ping
authors.initials: LP
authors.lastname: Zhu
authors.forename: Xiao-Quan
authors.initials: XQ
authors.lastname: Yang
authors.forename: Xiu-Ting
authors.initials: XT
authors.lastname: He
authors.forename: Jin-Mei
authors.initials: JM
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Guo
authors.forename: Jun-Ru
authors.initials: JR
authors.lastname: Qi
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Wang
authors.forename: Shou-Wei
authors.initials: SW
authors.lastname: Yin
mesh_terms: D016503:Drug Delivery Systems; D005511:Food Handling; D057927:Hydrophobic and Hydrophilic Interactions; D044243:Linoleic Acids, Conjugated / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D030262:Soybean Proteins / Q000737:chemistry*; D014465:Ultrasonics / Q000379:methods
chemical_list: D044243:Linoleic Acids, Conjugated; D030262:Soybean Proteins