title: CD8+T Cell Responses toPlasmodiumand Intracellular Parasites.
abstract: Parasitic protozoa are major threats to human health affecting millions of people around the world. Control of these infections by the host immune system relies on a myriad of immunological mechanisms that includes both humoral and cellular immunity. CD8+T cells contribute to the control of these parasitic infections in both animals and humans. Here, we will focus on the CD8+T cell response against a subset of these protozoa:Plasmodium, Toxoplasma gondii, Leishmania and Trypanosoma cruzi, with an emphasis on experimental rodent systems. It is evident a complex interaction occurs between CD8+T cells and the invading protozoa. A detailed understanding of how CD8+T cells mediate protection should provide the basis for the development of effective vaccines that prevent and control infections by these parasites.
authors.affiliation: Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Villarino
authors.affiliation: Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Schmidt
keywords: CD8+ T cell; Leishmania; Plasmodium; Toxoplasma; Trypanosoma.; immunity; malaria; protozoa
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