title: Dynamic self-assembly of polycationic clusters based on cyclodextrins for pH-sensitive DNA nanocondensation and delivery by component design.
abstract: The ability of cyclodextrin-based polycationic cluster to undergo reversible DNA condensation and release in a physiologically useful pH window has been finely tuned by the installation of a capping xylylene moiety at the secondary face of the cyclooligosaccharide. This strategy can be exploited advantageously in the design of self-assembling nonviral gene-delivery systems from molecular entities.
authors.affiliation: Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, c/Profesor García González 1, 41011 Sevilla (Spain), Fax: (+34) 954624960.
authors.forename: Laura
authors.initials: L
authors.lastname: Gallego-Yerga
authors.forename: M José
authors.initials: MJ
authors.lastname: González-Álvarez
authors.forename: Natalia
authors.initials: N
authors.lastname: Mayordomo
authors.forename: Francisco
authors.initials: F
authors.lastname: Santoyo-González
authors.forename: Juan M
authors.initials: JM
authors.lastname: Benito
authors.forename: Carmen
authors.initials: C
authors.lastname: Ortiz Mellet
authors.forename: Francisco
authors.initials: F
authors.lastname: Mendicuti
authors.forename: José M
authors.initials: JM
authors.lastname: García Fernández
mesh_terms: D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D002942:Circular Dichroism; D003505:Cyclodextrins / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D019281:Dimerization; D006863:Hydrogen-Ion Concentration; D049329:Nanostructures / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry; D000071228:Polyelectrolytes; D014162:Transfection
chemical_list: D003505:Cyclodextrins; D004247:DNA; D011073:Polyamines; D000071228:Polyelectrolytes
keywords: cyclodextrin; fluorescence; gene delivery; pH sensitivity; self-assembly