title: Synthesis of β-cyclodextrin modified chitosan-poly(acrylic acid) nanoparticles and use as drug carriers.
abstract: β-Cyclodextrin modified chitosan-poly(acrylic acid) nanoparticles (CS-PAACD NPs) were obtained by polymerizing acrylic acid (AA) and β-cyclodextrin (β-CD) substituted acrylic acid (AACD) in chitosan (CS) solution. These CS-PAACD NPs, characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM) as well as atomic force microscopy (AFM), were quite small in size about 40-50 nm. The size and the microstructure of these CS-PAACD NPs could be accurately controlled by changing the ration of AACD to AA. As the ratio of AACD to AA increased, the size of these NPs decreased. These as-prepared CS-PAACD NPs showed enhanced solubility for paclitaxel (PTX) in aqueous solution and exhibited a typical pH-sensitive release property for the encapsulated drug in vitro. The presence of the β-cyclodextrin inside the CS-PACD NPs greatly enhanced the ability to load hydrophobic drugs, which significantly broadened the application of CS-PAACD NPs in biomedical fields.
authors.affiliation: Nanjing National Laboratory of Microstructure, Department of Material Science & Engineering, Nanjing University, Nanjing 210093, PR China.
authors.forename: Xue
authors.initials: X
authors.lastname: Wang
authors.affiliation: Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
authors.forename: Changjing
authors.initials: C
authors.lastname: Chen
authors.affiliation: Nanjing National Laboratory of Microstructure, Department of Material Science & Engineering, Nanjing University, Nanjing 210093, PR China.
authors.forename: Da
authors.initials: D
authors.lastname: Huo
authors.affiliation: Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
authors.forename: Hanqing
authors.initials: H
authors.lastname: Qian
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Nanjing National Laboratory of Microstructure, Department of Material Science & Engineering, Nanjing University, Nanjing 210093, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
authors.forename: Xiqun
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage / Q000138:chemical synthesis*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D048271:Chitosan / Q000008:administration & dosage / Q000138:chemical synthesis*; D004337:Drug Carriers / Q000008:administration & dosage / Q000138:chemical synthesis*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D047392:beta-Cyclodextrins / Q000008:administration & dosage / Q000138:chemical synthesis*
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; D047392:beta-Cyclodextrins; C065246:chitosan-poly(acrylic acid); D048271:Chitosan; C031215:betadex