title: The glutathione system: a new drug target in neuroimmune disorders.
abstract: Glutathione (GSH) has a crucial role in cellular signaling and antioxidant defenses either by reacting directly with reactive oxygen or nitrogen species or by acting as an essential cofactor for GSH S-transferases and glutathione peroxidases. GSH acting in concert with its dependent enzymes, known as the glutathione system, is responsible for the detoxification of reactive oxygen and nitrogen species (ROS/RNS) and electrophiles produced by xenobiotics. Adequate levels of GSH are essential for the optimal functioning of the immune system in general and T cell activation and differentiation in particular. GSH is a ubiquitous regulator of the cell cycle per se. GSH also has crucial functions in the brain as an antioxidant, neuromodulator, neurotransmitter, and enabler of neuron survival. Depletion of GSH leads to exacerbation of damage by oxidative and nitrosative stress; hypernitrosylation; increased levels of proinflammatory mediators and inflammatory potential; dysfunctions of intracellular signaling networks, e.g., p53, nuclear factor-κB, and Janus kinases; decreased cell proliferation and DNA synthesis; inactivation of complex I of the electron transport chain; activation of cytochrome c and the apoptotic machinery; blockade of the methionine cycle; and compromised epigenetic regulation of gene expression. As such, GSH depletion has marked consequences for the homeostatic control of the immune system, oxidative and nitrosative stress (O&NS) pathways, regulation of energy production, and mitochondrial survival as well. GSH depletion and concomitant increase in O&NS and mitochondrial dysfunctions play a role in the pathophysiology of diverse neuroimmune disorders, including depression, myalgic encephalomyelitis/chronic fatigue syndrome and Parkinson's disease, suggesting that depleted GSH is an integral part of these diseases. Therapeutical interventions that aim to increase GSH concentrations in vivo include N-acetyl cysteine; Nrf-2 activation via hyperbaric oxygen therapy; dimethyl fumarate; phytochemicals, including curcumin, resveratrol, and cinnamon; and folate supplementation.
authors.affiliation: Tir Na Nog, Bryn Road Seaside 87, Llanelli, SA152LW, Wales, UK.
authors.forename: Gerwyn
authors.initials: G
authors.lastname: Morris
authors.forename: George
authors.initials: G
authors.lastname: Anderson
authors.forename: Olivia
authors.initials: O
authors.lastname: Dean
authors.forename: Michael
authors.initials: M
authors.lastname: Berk
authors.forename: Piotr
authors.initials: P
authors.lastname: Galecki
authors.forename: Marta
authors.initials: M
authors.lastname: Martin-Subero
authors.forename: Michael
authors.initials: M
authors.lastname: Maes
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001927:Brain Diseases / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D015213:Neuroimmunomodulation / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology*; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D005978:Glutathione
references.citation: J Biol Chem. 2005 Nov 11;280(45):37423-9
references.pmid: 16144837
references.citation: Mol Cell Biochem. 2006 Jun;286(1-2):95-101
references.pmid: 16583144
references.citation: J Affect Disord. 2011 Dec;135(1-3):389-94
references.pmid: 21719110
references.citation: Med Gas Res. 2012 Apr 11;2(1):9
references.pmid: 22494892
references.citation: J Med Food. 2005 Spring;8(1):47-52
references.pmid: 15857209
references.citation: FASEB J. 2005 Sep;19(11):1504-6
references.pmid: 15972297
references.citation: Toxicology. 2011 May 10;283(2-3):65-87
references.pmid: 21414382
references.citation: J Biol Chem. 2007 Jul 13;282(28):20416-24
references.pmid: 17452333
references.citation: Neuropeptides. 1994 Jul;27(1):19-26
references.pmid: 7969817
references.citation: Behav Brain Res. 2009 Dec 28;205(2):414-20
references.pmid: 19643148
references.citation: Biochem J. 1996 Dec 15;320 ( Pt 3):1005-10
references.pmid: 9003392
references.citation: Nutrients. 2012 Oct 09;4(10):1399-440
references.pmid: 23201762
references.citation: Eur Respir J. 1999 Jul;14(1):98-105
references.pmid: 10489835
references.citation: Eur J Neurosci. 2000 Oct;12(10):3721-8
references.pmid: 11029642
references.citation: Antioxid Redox Signal. 2011 Jul 1;15(1):39-47
references.pmid: 20673163
references.citation: Antiviral Res. 2008 Feb;77(2):120-7
references.pmid: 18164447
references.citation: Mol Aspects Med. 2009 Feb-Apr;30(1-2):77-85
references.pmid: 19232542
references.citation: Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1967-72
references.pmid: 9050888
references.citation: Mol Pharmacol. 2004 Mar;65(3):550-7
references.pmid: 14978233
references.citation: Mol Biol Rep. 2011 Jun;38(5):3391-4
references.pmid: 21107728
references.citation: J Affect Disord. 1998 Mar;48(2-3):149-55
references.pmid: 9543204
references.citation: Eur J Clin Invest. 1998 Mar;28(3):194-6
references.pmid: 9568464
references.citation: J Biol Chem. 2010 Dec 31;285(53):41525-32
references.pmid: 21037289
references.citation: Immunobiology. 2009;214(1):33-9
references.pmid: 19159825
references.citation: Biochem Biophys Res Commun. 2010 Jul 2;397(3):420-4
references.pmid: 20510876
references.citation: Prostaglandins Leukot Essent Fatty Acids. 2009 Nov-Dec;81(5-6):303-5
references.pmid: 19906518
references.citation: Biochemistry (Mosc). 2005 Feb;70(2):200-14
references.pmid: 15807660
references.citation: J Neurosci. 1999 Jan 15;19(2):562-9
references.pmid: 9880576
references.citation: Arch Biochem Biophys. 2007 Mar 15;459(2):295-300
references.pmid: 17169322
references.citation: Annu Rev Pharmacol Toxicol. 2005;45:51-88
references.pmid: 15822171
references.citation: Biofactors. 2003;17(1-4):115-30
references.pmid: 12897434
references.citation: Cancer Biol Ther. 2006 May;5(5):492-7
references.pmid: 16582599
references.citation: Lancet. 2008 Oct 25;372(9648):1463-72
references.pmid: 18970976
references.citation: Metab Brain Dis. 2013 Dec;28(4):523-40
references.pmid: 22718491
references.citation: Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1261-4
references.pmid: 8108398
references.citation: Science. 1992 Oct 23;258(5082):597-603
references.pmid: 1329206
references.citation: Anal Biochem. 1996 Oct 1;241(1):75-81
references.pmid: 8921168
references.citation: CNS Spectr. 2007 Oct;12(10):739-44
references.pmid: 17934378
references.citation: Chem Res Toxicol. 2008 Nov;21(11):2134-47
references.pmid: 18828639
references.citation: Comp Biochem Physiol C Toxicol Pharmacol. 2011 Mar;153(2):175-90
references.pmid: 20959147
references.citation: Pharmacogenetics. 2001 Nov;11(8):663-9
references.pmid: 11692074
references.citation: AIDS Res Hum Retroviruses. 1996 Nov 1;12(16):1537-41
references.pmid: 8911579
references.citation: Antioxid Redox Signal. 2006 May-Jun;8(5-6):813-22
references.pmid: 16771672
references.citation: J Biol Chem. 2007 Oct 19;282(42):30452-65
references.pmid: 17724027
references.citation: Curr Neurol Neurosci Rep. 2013 Nov;13(11):394
references.pmid: 24061646
references.citation: Biol Psychiatry. 2008 Sep 15;64(6):468-75
references.pmid: 18534556
references.citation: Brain Res. 2001 Mar 9;894(1):131-40
references.pmid: 11245823
references.citation: Annu Rev Pharmacol Toxicol. 2002;42:585-600
references.pmid: 11807184
references.citation: ASN Neuro. 2011 Apr 07;3(2):
references.pmid: 21382015
references.citation: Redox Biol. 2013 Sep 12;1:441-5
references.pmid: 24191238
references.citation: Adv Exp Med Biol. 1992;317:131-6
references.pmid: 1288120
references.citation: Oral Dis. 2011 Oct;17(7):677-84
references.pmid: 21729219
references.citation: Hum Mol Genet. 2008 Sep 15;17(18):2790-802
references.pmid: 18562474
references.citation: Planta Med. 2008 Oct;74(13):1526-39
references.pmid: 18937164
references.citation: Immunobiology. 2013 Sep;218(9):1166-74
references.pmid: 23669236
references.citation: Am J Psychiatry. 2012 Dec;169(12):1267-74
references.pmid: 23212058
references.citation: J Pharmacol Sci. 2008 Nov;108(3):227-38
references.pmid: 19008644
references.citation: J Biol Chem. 2007 Oct 26;282(43):31124-30
references.pmid: 17690099
references.citation: J Exp Med. 1995 Dec 1;182(6):1785-92
references.pmid: 7500023
references.citation: Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8841-2
references.pmid: 15187230
references.citation: Int J Mol Med. 2007 Jan;19(1):165-72
references.pmid: 17143561
references.citation: Eur J Clin Pharmacol. 1996;50(6):457-61
references.pmid: 8858271
references.citation: Biochim Biophys Acta. 2008 Nov;1780(11):1273-90
references.pmid: 18267127
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):744-59
references.pmid: 20828592
references.citation: Cardiovasc Res. 2007 Jul 15;75(2):220-8
references.pmid: 17451659
references.citation: Ann Neurol. 1995 Sep;38(3):357-66
references.pmid: 7668820
references.citation: Free Radic Biol Med. 2005 Sep 1;39(5):584-9
references.pmid: 16085177
references.citation: Biochem Biophys Res Commun. 1998 Jun 18;247(2):481-6
references.pmid: 9642155
references.citation: Altern Med Rev. 2001 Oct;6(5):450-9
references.pmid: 11703165
references.citation: AIDS. 1992 Aug;6(8):815-9
references.pmid: 1418777
references.citation: J Biol Chem. 2001 Dec 21;276(51):48083-92
references.pmid: 11675377
references.citation: Antiviral Res. 1995 Jun;27(3):237-53
references.pmid: 8540746
references.citation: Biochim Biophys Acta. 2013 May;1830(5):3304-16
references.pmid: 23069719
references.citation: Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15565-70
references.pmid: 20713697
references.citation: Curr Opin Pharmacol. 2007 Aug;7(4):355-9
references.pmid: 17602868
references.citation: EMBO J. 2011 May 18;30(10):2044-56
references.pmid: 21478822
references.citation: Antioxid Redox Signal. 2009 Nov;11(11):2717-39
references.pmid: 19558211
references.citation: PLoS One. 2013 Apr 17;8(4):e61271
references.pmid: 23613825
references.citation: Mol Cell Biochem. 2006 Dec;293(1-2):161-71
references.pmid: 16786188
references.citation: J Biol Chem. 2006 Dec 29;281(52):40354-68
references.pmid: 17071618
references.citation: Biochem Biophys Res Commun. 2009 May 8;382(3):549-54
references.pmid: 19289108
references.citation: Arch Biochem Biophys. 2002 Dec 1;408(1):1-6
references.pmid: 12485597
references.citation: J Nutr. 2006 Jun;136(6 Suppl):1660S-1665S
references.pmid: 16702336
references.citation: Science. 1993 Oct 29;262(5134):689-95
references.pmid: 7901908
references.citation: Braz J Psychiatry. 2011 Dec;33(4):374-8
references.pmid: 22189927
references.citation: Neuro Endocrinol Lett. 2013;34(3):185-99
references.pmid: 23685416
references.citation: J Biol Chem. 2007 Jun 22;282(25):18427-18436
references.pmid: 17468103
references.citation: Free Radic Biol Med. 2008 Aug 15;45(4):385-95
references.pmid: 18482591
references.citation: Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1491-6
references.pmid: 11792859
references.citation: Curr Med Chem. 2005;12(10):1161-208
references.pmid: 15892631
references.citation: Free Radic Biol Med. 2008 Nov 1;45(9):1252-62
references.pmid: 18694818
references.citation: Cell Immunol. 2011;270(1):53-61
references.pmid: 21550026
references.citation: J Neurosci Res. 2001 Dec 1;66(5):1003-8
references.pmid: 11746430
references.citation: Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):117-22
references.pmid: 15618409
references.citation: Antioxid Redox Signal. 2005 Jan-Feb;7(1-2):32-41
references.pmid: 15650394
references.citation: Int J Biochem Cell Biol. 2012 Dec;44(12):2106-15
references.pmid: 22939972
references.citation: Pflugers Arch. 2001 May;442(2):286-96
references.pmid: 11417227
references.citation: J Neuroinflammation. 2004 Nov 04;1(1):22
references.pmid: 15527505
references.citation: Mol Cell Biol. 2008 Feb;28(4):1338-47
references.pmid: 18086890
references.citation: Neurochem Res. 1989 Dec;14(12):1223-7
references.pmid: 2576463
references.citation: Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13
references.pmid: 12193649
references.citation: J Biol Chem. 2004 Mar 5;279(10):8919-29
references.pmid: 14688281
references.citation: J Biol Chem. 2010 Sep 3;285(36):27850-8
references.pmid: 20558743
references.citation: Neuroreport. 1991 Jun;2(6):345-7
references.pmid: 1832987
references.citation: Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):665-70
references.pmid: 14704277
references.citation: Ann Clin Psychiatry. 1993 Jun;5(2):101-5
references.pmid: 8348200
references.citation: J Biol Chem. 1989 Aug 15;264(23):13519-23
references.pmid: 2788161
references.citation: Int J Neuropsychopharmacol. 2011 Sep;14(8):1069-74
references.pmid: 21733244
references.citation: Cell Immunol. 1992 Apr;140(2):390-9
references.pmid: 1544168
references.citation: Carcinogenesis. 1985 Dec;6(12):1735-45
references.pmid: 3905042
references.citation: Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):865-77
references.pmid: 20175987
references.citation: ScientificWorldJournal. 2009 Nov 01;9:1233-41
references.pmid: 19882093
references.citation: Mol Cancer Ther. 2006 Jan;5(1):39-51
references.pmid: 16432161
references.citation: Biochem Biophys Res Commun. 2007 Jun 8;357(3):575-8
references.pmid: 17434454
references.citation: Cancer Lett. 1997 Dec 9;120(2):149-56
references.pmid: 9461031
references.citation: J Altern Complement Med. 2013 Feb;19(2):134-40
references.pmid: 22757691
references.citation: Nat Chem Biol. 2009 Oct;5(10):721-3
references.pmid: 19718041
references.citation: J Biol Chem. 2009 Mar 27;284(13):8233-40
references.pmid: 19176520
references.citation: Int J Biochem Cell Biol. 2007;39(1):44-84
references.pmid: 16978905
references.citation: J Biol Chem. 2002 Nov 8;277(45):43505-11
references.pmid: 12189155
references.citation: J Geriatr Psychiatry Neurol. 2012 Mar;25(1):43-50
references.pmid: 22467846
references.citation: J Psychiatr Res. 2012 Oct;46(10):1326-32
references.pmid: 22841833
references.citation: Am J Clin Nutr. 2009 Dec;90(6):1615-22
references.pmid: 19828710
references.citation: Hum Pathol. 2004 Aug;35(8):1000-7
references.pmid: 15297967
references.citation: Neurosci Res. 2000 May;37(1):15-9
references.pmid: 10802340
references.citation: Allergy. 2011 Sep;66(9):1183-92
references.pmid: 21545428
references.citation: Mol Psychiatry. 2013 May;18(5):595-606
references.pmid: 22525486
references.citation: Antioxid Redox Signal. 2004 Feb;6(1):63-74
references.pmid: 14713336
references.citation: J Clin Invest. 1934 Nov;13(6):963-8
references.pmid: 16694262
references.citation: Toxicol Appl Pharmacol. 2012 Jun 1;261(2):181-8
references.pmid: 22521609
references.citation: BMC Psychiatry. 2013 Jul 25;13:196
references.pmid: 23886027
references.citation: Biochemistry. 2001 Feb 13;40(6):1688-93
references.pmid: 11327828
references.citation: Neuro Endocrinol Lett. 2009;30(4):462-9
references.pmid: 20010493
references.citation: J Pharmacol Exp Ther. 2011 Jan;336(1):206-14
references.pmid: 20876229
references.citation: Neoplasia. 2007 Dec;9(12):1111-21
references.pmid: 18084618
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2013 Apr 5;42:135-45
references.pmid: 23178231
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3941-5
references.pmid: 19223582
references.citation: J Biol Chem. 2009 Jan 2;284(1):436-445
references.pmid: 18990698
references.citation: Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3071-6
references.pmid: 9501217
references.citation: Neurology. 2002 May 14;58(9):1395-9
references.pmid: 12011287
references.citation: Carcinogenesis. 2000 Oct;21(10):1795-9
references.pmid: 11023535
references.citation: Arch Med Res. 2007 Jan;38(1):94-8
references.pmid: 17174731
references.citation: Arch Biochem Biophys. 2004 Mar 1;423(1):66-73
references.pmid: 14989266
references.citation: Pharmacol Biochem Behav. 2013 Mar;104:105-12
references.pmid: 23313551
references.citation: Toxicol Lett. 1996 Jan;84(1):7-12
references.pmid: 8597179
references.citation: Med Hypotheses. 2001 Aug;57(2):231-7
references.pmid: 11461179
references.citation: J Affect Disord. 2009 Mar;113(3):285-90
references.pmid: 18579214
references.citation: Arch Biochem Biophys. 2010 Nov 15;503(2):248-52
references.pmid: 20804722
references.citation: Biochem Biophys Res Commun. 2006 Mar 24;341(4):1007-16
references.pmid: 16460683
references.citation: Anal Bioanal Chem. 2008 Jan;390(2):679-88
references.pmid: 17965853
references.citation: Free Radic Biol Med. 2012 Aug 15;53(4):962-73
references.pmid: 22634394
references.citation: J Cell Physiol. 2011 Sep;226(9):2329-37
references.pmid: 21660956
references.citation: Neuron. 1989 Jun;2(6):1547-58
references.pmid: 2576375
references.citation: Biochemistry. 1991 Sep 10;30(36):8883-91
references.pmid: 1888746
references.citation: J Biol Chem. 2003 Jan 3;278(1):241-50
references.pmid: 12414812
references.citation: Fundam Clin Pharmacol. 2009 Feb;23(1):89-95
references.pmid: 19207541
references.citation: Mutat Res. 2001 Sep 1;480-481:231-41
references.pmid: 11506817
references.citation: Biochemistry. 2001 Nov 27;40(47):14134-42
references.pmid: 11714266
references.citation: J Inherit Metab Dis. 2005;28(1):81-8
references.pmid: 15702408
references.citation: J Amino Acids. 2012;2012:736837
references.pmid: 22500213
references.citation: Carcinogenesis. 2012 Apr;33(4):723-31
references.pmid: 22235026
references.citation: Sci Rep. 2012;2:667
references.pmid: 22993692
references.citation: Transl Psychiatry. 2012 Jul 10;2:e134
references.pmid: 22781167
references.citation: Free Radic Biol Med. 2000 Dec 15;29(12):1252-9
references.pmid: 11118815
references.citation: Exp Neurol. 2007 Feb;203(2):512-20
references.pmid: 17049515
references.citation: Arch Pediatr Adolesc Med. 2007 Apr;161(4):356-61
references.pmid: 17404132
references.citation: Biol Psychiatry. 1998 Mar 1;43(5):315-9
references.pmid: 9513745
references.citation: J Biol Chem. 2008 Oct 24;283(43):29126-34
references.pmid: 18708636
references.citation: Carcinogenesis. 2008 May;29(5):1022-32
references.pmid: 18321868
references.citation: Neurochem Res. 2008 Jan;33(1):194-203
references.pmid: 17605107
references.citation: Mutat Res. 2002 Oct 31;508(1-2):157-65
references.pmid: 12379471
references.citation: Free Radic Res. 2008 Aug;42(8):689-706
references.pmid: 18671159
references.citation: Arthritis Rheum. 2007 Jan;56(1):244-54
references.pmid: 17195228
references.citation: J Exp Med. 2000 Sep 18;192(6):907-12
references.pmid: 10993921
references.citation: Aging (Milano). 1993 Feb;5(1):63-71
references.pmid: 8257478
references.citation: Biochem J. 2010 Oct 15;431(2):169-78
references.pmid: 20874710
references.citation: Annu Rev Pharmacol Toxicol. 2003;43:233-60
references.pmid: 12359864
references.citation: Free Radic Biol Med. 2006 Mar 15;40(6):928-39
references.pmid: 16540388
references.citation: J Affect Disord. 2012 Dec 20;143(1-3):34-8
references.pmid: 22840610
references.citation: Cytokine. 2000 Sep;12(9):1391-4
references.pmid: 10976000
references.citation: Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4311-9
references.pmid: 16249513
references.citation: J Invest Dermatol. 2010 Dec;130(12):2781-9
references.pmid: 20664557
references.citation: Mutat Res. 1997 Apr 14;375(1):1-8
references.pmid: 9129674
references.citation: Phytother Res. 2014 Apr;28(4):579-85
references.pmid: 23832433
references.citation: Biochemistry. 2007 Jul 3;46(26):7765-80
references.pmid: 17555331
references.citation: Inflammopharmacology. 2012 Jun;20(3):127-50
references.pmid: 22271002
references.citation: Mol Interv. 2007 Dec;7(6):313-24
references.pmid: 18199853
references.citation: Int J Neuropsychopharmacol. 2011 Feb;14(1):123-30
references.pmid: 20633320
references.citation: Free Radic Res. 2010 Jul;44(7):721-33
references.pmid: 20528574
references.citation: J Immunol. 2004 Jul 1;173(1):285-96
references.pmid: 15210786
references.citation: Pharmacol Biochem Behav. 2008 Jun;89(4):563-71
references.pmid: 18336891
references.citation: J Toxicol Environ Health. 1994 Apr;41(4):387-409
references.pmid: 8145281
references.citation: J Neurochem. 2007 Jun;101(5):1205-13
references.pmid: 17403030
references.citation: Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1138-48
references.pmid: 20388492
references.citation: Blood. 1984 Jan;63(1):96-104
references.pmid: 6418237
references.citation: Dose Response. 2006 May 01;3(3):425-42
references.pmid: 18648617
references.citation: Biol Pharm Bull. 2011;34(3):354-9
references.pmid: 21372384
references.citation: Scand J Clin Lab Invest. 2012 Apr;72(2):152-7
references.pmid: 22208644
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3780-5
references.pmid: 15004285
references.citation: Diabetes Nutr Metab. 2004 Apr;17(2):95-102
references.pmid: 15244101
references.citation: PLoS One. 2013;8(1):e55407
references.pmid: 23383181
references.citation: Life Sci. 2007 Feb 27;80(12):1087-93
references.pmid: 17291539
references.citation: Biochem J. 2001 Nov 15;360(Pt 1):1-16
references.pmid: 11695986
references.citation: Brain Res. 2011 Sep 15;1412:63-72
references.pmid: 21803336
references.citation: Curr Pharm Des. 2014;20(23):3812-47
references.pmid: 24180395
references.citation: Cell Death Differ. 2009 Oct;16(10):1303-14
references.pmid: 19662025
references.citation: J Appl Physiol (1985). 2009 Mar;106(3):988-95
references.pmid: 18845776
references.citation: Cell Calcium. 2012 Jul;52(1):36-43
references.pmid: 22480931
references.citation: Biochem J. 2009 Jan 1;417(1):1-13
references.pmid: 19061483
references.citation: Antioxid Redox Signal. 2008 Aug;10(8):1343-74
references.pmid: 18522489
references.citation: Am J Psychiatry. 1997 Mar;154(3):426-8
references.pmid: 9054796
references.citation: BMJ. 2002 Jun 22;324(7352):1512-5
references.pmid: 12077044
references.citation: Int Rev Neurobiol. 1976;19:75-121
references.pmid: 13046
references.citation: Mol Genet Metab. 2013 Jun;109(2):208-14
references.pmid: 23583222
references.citation: PLoS One. 2011;6(5):e20676
references.pmid: 21655192
references.citation: Med Hypotheses. 2012 Nov;79(5):607-13
references.pmid: 22951418
references.citation: Redox Rep. 2000;5(2-3):146-7
references.pmid: 10939298
references.citation: Neuroscience. 2007 Nov 23;149(4):917-30
references.pmid: 17936517
references.citation: J Biol Chem. 2003 May 30;278(22):19603-10
references.pmid: 12649289
references.citation: Mol Cell Biochem. 2007 Nov;305(1-2):235-53
references.pmid: 17562131
references.citation: J Biol Chem. 2010 Jul 30;285(31):23557-67
references.pmid: 20498365
references.citation: Biochem Pharmacol. 2002 Sep;64(5-6):1049-56
references.pmid: 12213604
references.citation: J Biol Chem. 2007 Oct 5;282(40):29470-81
references.pmid: 17690092
references.citation: J Neurosci. 1995 Mar;15(3 Pt 1):1835-53
references.pmid: 7891138
references.citation: Eur J Clin Invest. 1996 Jan;26(1):38-44
references.pmid: 8682153
references.citation: Cell Immunol. 1990 Oct 15;130(2):520-8
references.pmid: 2208308
references.citation: Biochim Biophys Acta. 2004 Jul 23;1658(1-2):44-9
references.pmid: 15282173
references.citation: Oncogene. 2006 Mar 13;25(11):1639-48
references.pmid: 16550164
references.citation: Immunity. 1994 Apr;1(1):65-72
references.pmid: 7889400
references.citation: Cell Stress Chaperones. 2010 Jul;15(4):431-42
references.pmid: 19949909
references.citation: J Intern Med. 2005 Mar;257(3):299-310
references.pmid: 15715687
references.citation: Neurosci Biobehav Rev. 1997 Mar;21(2):151-66
references.pmid: 9062938
references.citation: Biochemistry. 2010 Feb 16;49(6):1059-66
references.pmid: 20070126
references.citation: Pulm Pharmacol Ther. 2007;20(1):9-22
references.pmid: 16458553
references.citation: Free Radic Biol Med. 2010 Dec 1;49(11):1617-28
references.pmid: 20851762
references.citation: J Biol Chem. 2001 Jun 1;276(22):19220-30
references.pmid: 11279091
references.citation: Chem Res Toxicol. 2009 Jun;22(6):1050-9
references.pmid: 19480392
references.citation: FASEB J. 2002 Aug;16(10):1263-5
references.pmid: 12060676
references.citation: Curr Neuropharmacol. 2009 Mar;7(1):60-4
references.pmid: 19721818
references.citation: Eur J Nutr. 2007 Jun;46(4):204-12
references.pmid: 17464446
references.citation: Neurochem Res. 1997 Sep;22(9):1165-71
references.pmid: 9251108
references.citation: Biochem J. 2009 Dec 23;425(2):313-25
references.pmid: 20025614
references.citation: Proc West Pharmacol Soc. 1994;37:59-62
references.pmid: 7984674
references.citation: J Neuroinflammation. 2012 Dec 23;9:275
references.pmid: 23259598
references.citation: Aquat Toxicol. 2011 Jan 17;101(1):13-30
references.pmid: 21074869
references.citation: Acta Biochim Pol. 2003;50(2):319-36
references.pmid: 12833161
references.citation: J Leukoc Biol. 1997 Jul;62(1):54-9
references.pmid: 9225993
references.citation: J Biol Chem. 2001 Aug 3;276(31):29596-602
references.pmid: 11395496
references.citation: Free Radic Res. 2003 Mar;37(3):293-9
references.pmid: 12688424
references.citation: Antioxid Redox Signal. 2009 Nov;11(11):2685-700
references.pmid: 19558212
references.citation: Antioxid Redox Signal. 2007 Nov;9(11):2027-33
references.pmid: 17845131
references.citation: Arch Surg. 1993 Jan;128(1):29-34; discussion 34-5
references.pmid: 8418777
references.citation: Antioxid Redox Signal. 2010 Sep 1;13(5):575-87
references.pmid: 20367278
references.citation: Pharmacol Rep. 2008 Sep-Oct;60(5):664-72
references.pmid: 19066412
references.citation: J Neurosci. 2006 Mar 22;26(12):3345-56
references.pmid: 16554485
references.citation: Biochem J. 2000 May 1;347 Pt 3:821-7
references.pmid: 10769188
references.citation: Nat Cell Biol. 2008 Dec;10(12):1477-83
references.pmid: 19029908
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13086-91
references.pmid: 16916935
references.citation: BMC Med. 2013 Sep 17;11:205
references.pmid: 24229326
references.citation: J Biol Chem. 1999 Mar 5;274(10):6366-73
references.pmid: 10037727
references.citation: J Cataract Refract Surg. 2009 Dec;35(12):2149-53
references.pmid: 19969222
references.citation: Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1913-7
references.pmid: 2000395
references.citation: Free Radic Biol Med. 2003 Apr 1;34(7):928-36
references.pmid: 12654482
references.citation: Proc Natl Acad Sci U S A. 1990 May;87(9):3343-7
references.pmid: 1970635
references.citation: Hepatology. 2001 May;33(5):1181-8
references.pmid: 11343247
references.citation: J Affect Disord. 1996 Sep 9;40(1-2):23-33
references.pmid: 8882911
references.citation: Redox Biol. 2013 Jan 18;1:45-9
references.pmid: 24024136
references.citation: Cell. 2005 Feb 25;120(4):483-95
references.pmid: 15734681
references.citation: Biofactors. 2008;32(1-4):179-83
references.pmid: 19096114
references.citation: Biochem Biophys Res Commun. 2002 Apr 26;293(1):610-6
references.pmid: 12054646
references.citation: Circ Res. 2010 Jan 8;106(1):193-202
references.pmid: 19910579
references.citation: J Cell Mol Med. 2004 Apr-Jun;8(2):201-12
references.pmid: 15256068
references.citation: Eur J Immunol. 2002 Oct;32(10):2866-73
references.pmid: 12355439
references.citation: Am J Respir Cell Mol Biol. 2009 Nov;41(5):509-15
references.pmid: 19684307
references.citation: Oxid Med Cell Longev. 2010 Jan-Feb;3(1):2-12
references.pmid: 20716923
references.citation: J Biol Chem. 2007 Nov 9;282(45):32640-54
references.pmid: 17848555
references.citation: Biomed Pharmacother. 2008 Apr-May;62(4):236-49
references.pmid: 18400456
references.citation: Free Radic Biol Med. 2009 Feb 15;46(4):443-53
references.pmid: 19028565
references.citation: J Periodontal Res. 2005 Oct;40(5):378-84
references.pmid: 16105090
references.citation: Carcinogenesis. 2007 Sep;28(9):1937-45
references.pmid: 17698970
references.citation: J Nutr Biochem. 2011 Dec;22(12):1186-94
references.pmid: 21334869
references.citation: Annu Rev Pharmacol Toxicol. 2007;47:143-83
references.pmid: 17029566
references.citation: Blood. 1997 Jun 1;89(11):4092-9
references.pmid: 9166850
references.citation: Clin Exp Metastasis. 1997 May;15(3):329-37
references.pmid: 9174132
references.citation: Free Radic Res. 1995 Aug;23(2):91-101
references.pmid: 7581815
references.citation: J Neurosci. 2007 Apr 11;27(15):3946-55
references.pmid: 17428968
references.citation: Psychiatry Res. 2011 May 30;187(3):454-6
references.pmid: 21093063
references.citation: Methods Enzymol. 1999;300:219-26
references.pmid: 9919524
references.citation: Biol Chem. 2003 Apr;384(4):505-16
references.pmid: 12751781
references.citation: PLoS One. 2008 Apr 09;3(4):e1944
references.pmid: 18398470
references.citation: Int J Cell Biol. 2012;2012:434971
references.pmid: 22745639
references.citation: Phytother Res. 2012 Jan;26(1):18-25
references.pmid: 21538625
references.citation: Clin Neuropharmacol. 2013 Nov-Dec;36(6):185-92
references.pmid: 24201233
references.citation: J Biol Chem. 2003 May 2;278(18):15720-6
references.pmid: 12595536
references.citation: Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L478-88
references.pmid: 18162601
references.citation: Cardiovasc Res. 2004 Apr 1;62(1):43-52
references.pmid: 15023551
references.citation: Methods Enzymol. 2002;348:93-112
references.pmid: 11885298
references.citation: J Gen Physiol. 2012 Jun;139(6):479-91
references.pmid: 22585969
references.citation: J Affect Disord. 2011 Jun;131(1-3):207-13
references.pmid: 21277635
references.citation: J Neurochem. 2005 Mar;92(5):1091-103
references.pmid: 15715660
references.citation: Neuroscience. 2006 Feb;137(3):807-19
references.pmid: 16330153
references.citation: Annu Rev Pharmacol Toxicol. 2013;53:59-87
references.pmid: 23020296
references.citation: Zhen Ci Yan Jiu. 2012 Feb;37(1):38-40, 58
references.pmid: 22574567
references.citation: J Neurochem. 1980 Nov;35(5):1242-5
references.pmid: 7452315
references.citation: Trends Pharmacol Sci. 2006 Dec;27(12):639-45
references.pmid: 17056127
references.citation: Neuro Endocrinol Lett. 2011;32(2):133-40
references.pmid: 21552194
references.citation: Free Radic Biol Med. 2012 May 1;52(9):1854-64
references.pmid: 22387197
references.citation: Arch Biochem Biophys. 1998 Aug 15;356(2):127-32
references.pmid: 9705202
references.citation: Mol Brain. 2012 Apr 09;5:11
references.pmid: 22487454
references.citation: J Neurosci. 2004 Sep 8;24(36):7779-88
references.pmid: 15356189
references.citation: Free Radic Biol Med. 2013 Oct;63:187-94
references.pmid: 23707456
references.citation: Parkinsons Dis. 2011 Mar 15;2011:716871
references.pmid: 21461368
references.citation: Antioxid Redox Signal. 2012 Dec 15;17(12):1748-63
references.pmid: 22530666
references.citation: Toxicol Appl Pharmacol. 1986 Mar 30;83(1):142-7
references.pmid: 3952743
references.citation: Neurochem Res. 1998 Aug;23(8):1085-91
references.pmid: 9704598
references.citation: Adv Pharmacol. 1997;38:205-27
references.pmid: 8895810
references.citation: J Immunol. 1989 Sep 15;143(6):1974-81
references.pmid: 2789253
references.citation: Nutrition. 2011 Feb;27(2):199-205
references.pmid: 20471805
references.citation: Obesity (Silver Spring). 2012 Oct;20(10):1974-83
references.pmid: 22327056
references.citation: J Neurosci. 2003 Jun 15;23(12):5088-95
references.pmid: 12832532
references.citation: Psychiatry Res. 2012 Jun 30;198(1):166-8
references.pmid: 22374552
references.citation: J Neurochem. 2002 Nov;83(4):984-91
references.pmid: 12421371
references.citation: Neurotoxicology. 2008 Jan;29(1):190-201
references.pmid: 18031821
references.citation: Neurosci Lett. 1991 Nov 25;133(1):11-4
references.pmid: 1838798
references.citation: Mol Carcinog. 2011 Aug;50(8):580-91
references.pmid: 21319226
references.citation: Free Radic Biol Med. 2007 Oct 1;43(7):1023-36
references.pmid: 17761298
references.citation: Biosci Rep. 1997 Jun;17(3):293-302
references.pmid: 9337484
references.citation: J Pharmacol Exp Ther. 1986 Jul;238(1):54-61
references.pmid: 3723405
references.citation: Science. 1997 Jun 13;276(5319):1699-702
references.pmid: 9180080
references.citation: Metab Brain Dis. 2014 Mar;29(1):19-36
references.pmid: 24557875
references.citation: Antioxid Redox Signal. 2008 Nov;10(11):1941-88
references.pmid: 18774901
references.citation: Nat Rev Cancer. 2008 Dec;8(12):967-75
references.pmid: 18987634
references.citation: Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3505-10
references.pmid: 11904414
references.citation: J Appl Physiol (1985). 2012 Jul;113(1):105-13
references.pmid: 22556393
references.citation: J Neurochem. 1999 Sep;73(3):889-902
references.pmid: 10461878
references.citation: Nurs Res Pract. 2013;2013:795784
references.pmid: 24058735
references.citation: Mol Immunol. 2005 May;42(9):987-1014
references.pmid: 15829290
references.citation: Nature. 1987 May 7-13;327(6117):77-9
references.pmid: 3574469
references.citation: Am Fam Physician. 2007 Aug 1;76(3):391-6
references.pmid: 17708140
references.citation: Neurochem Int. 2000 Aug-Sep;37(2-3):299-306
references.pmid: 10812215
references.citation: Indian J Exp Biol. 2002 Nov;40(11):1240-4
references.pmid: 13677625
references.citation: Biochem Pharmacol. 2002 Jan 15;63(2):305-20
references.pmid: 11841806
references.citation: PLoS One. 2009 Jul 29;4(7):e6413
references.pmid: 19641610
references.citation: J Cell Physiol. 1981 May;107(2):283-93
references.pmid: 7251686
references.citation: J Physiol. 2006 Dec 1;577(Pt 2):591-9
references.pmid: 17008380
references.citation: NMR Biomed. 2012 Sep;25(9):1073-87
references.pmid: 22281935
references.citation: Biochem Biophys Res Commun. 2010 May 21;396(1):120-4
references.pmid: 20494123
references.citation: Autism Res Treat. 2012;2012:190930
references.pmid: 22934169
references.citation: Annu Rev Pharmacol Toxicol. 2004;44:325-47
references.pmid: 14744249
references.citation: Biochim Biophys Acta. 2013 Aug;1830(8):4117-29
references.pmid: 23618697