title: Cortical microinfarcts on 7T MRI in patients with spontaneous intracerebral hemorrhage.
abstract: In patients with spontaneous intracerebral hemorrhage (ICH) coexisting abnormalities on brain imaging can provide clues on the etiology of the underlying small vessel disease. We examined cortical cerebral microinfarcts as a novel marker of coexistent vascular damage in ICH. Twelve patients with spontaneous ICH and 15 controls underwent 7Tesla magnetic resonance imaging (MRI). Microinfarcts were present in 9 of 12 patients with spontaneous ICH, and in 5 of 15 controls. This explorative study shows, for the first time, that microinfarcts appear to be a very common vascular comorbidity in spontaneous ICH. Future larger studies should further assess the etiological significance of these lesions.
authors.affiliation: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Susanne J
authors.initials: SJ
authors.lastname: van Veluw
authors.affiliation: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Wilmar M T
authors.initials: WM
authors.lastname: Jolink
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hendrikse
authors.affiliation: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Mirjam I
authors.initials: MI
authors.lastname: Geerlings
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Luijten
authors.affiliation: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Geert Jan
authors.initials: GJ
authors.lastname: Biessels
authors.affiliation: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Catharina J M
authors.initials: CJ
authors.lastname: Klijn
mesh_terms: D000328:Adult; D000368:Aged; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000473:pathology*; D002544:Cerebral Infarction / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged
references.citation: J Cereb Blood Flow Metab. 2012 Mar;32(3):425-36
references.pmid: 22234334
references.citation: Brain Pathol. 2010 Mar;20(2):459-67
references.pmid: 19725828
references.citation: J Neurol Sci. 1993 Jun;116(2):135-41
references.pmid: 8336159
references.citation: Stroke. 2012 Aug;43(8):2258-63
references.pmid: 22821611
references.citation: Ann Neurol. 2013 Jun;73(6):795-6
references.pmid: 23494498
references.citation: J Cereb Blood Flow Metab. 2013 Mar;33(3):322-9
references.pmid: 23250109
references.citation: Ann Neurol. 2011 Nov;70(5):774-80
references.pmid: 22162060
references.citation: J Alzheimers Dis. 2014;39(1):163-7
references.pmid: 24121967
references.citation: Neurology. 2012 Dec 11;79(24):2335-41
references.pmid: 23197745
references.citation: Lancet Neurol. 2010 Feb;9(2):167-76
references.pmid: 20056489
references.citation: J Neurol Neurosurg Psychiatry. 2006 Nov;77(11):1244-52
references.pmid: 16690694
references.citation: J Alzheimers Dis. 2012;31(2):259-63
references.pmid: 22531417
references.citation: Neuroimage. 2012 Jul 16;61(4):1043-9
references.pmid: 22440643