title: TRPM4.
abstract: TRPM4 is a Ca(2+)-activated nonselective cation channel. The channel is activated by an increase of intracellular Ca(2+) and is regulated by several factors including temperature and Pi(4,5)P2. TRPM4 allows Na(+) entry into the cell upon activation, but is completely impermeable to Ca(2+). Unlike TRPM5, its closest relative in the transient receptor potential family, TRPM4 proteins are widely expressed in the body. Currents with properties that are reminiscent of TRPM4 have been described in a variety of tissues since the advent of the patch clamp technology, but their physiological role is only beginning to be clarified with the increasing characterization of knockout mouse models for TRPM4. Furthermore, mutations in the TRPM4 gene have been associated with cardiac conduction disorders in human patients. This review aims to overview the currently available data on the functional properties of TRPM4 and the current understanding of its physiological role in healthy and diseased tissue.
authors.affiliation: Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, bus 802, 3000, Leuven, Belgium.
authors.forename: Ilka
authors.initials: I
authors.lastname: Mathar
authors.forename: Griet
authors.initials: G
authors.lastname: Jacobs
authors.forename: Miklos
authors.initials: M
authors.lastname: Kecskes
authors.forename: Aurelie
authors.initials: A
authors.lastname: Menigoz
authors.forename: Koenraad
authors.initials: K
authors.lastname: Philippaert
authors.forename: Rudi
authors.initials: R
authors.lastname: Vennekens
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D008564:Membrane Potentials; D049990:Membrane Transport Modulators / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D011487:Protein Conformation; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D050053:TRPM Cation Channels / Q000737:chemistry / Q000172:deficiency / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*
chemical_list: D049990:Membrane Transport Modulators; D050053:TRPM Cation Channels; C437888:TRPM4 protein, human; C476766:TRPM4 protein, mouse