title: [The different contraction between rat gastric longitudinal and circular smooth muscle induced by extracellular nucleotides].
abstract: OBJECTIVE
  To test the different contrctile responses of extracellular nucleotides, such as ATP, UTP and nucleotide uridine adenosine tetraphosphate (Up4A) in gastric longitudinal muscle (LM) and circular muscle (CM). Examined the effect of P2X and P2Y receptor antagonists (in this study, we used IP5I and suramin) and cyclooxygenase inhibitor (indomethacin) on Up4A induced contractile responses in LM and CM.
  
  
  METHODS
  The rats were sacrificed and the stomachs were opened to gain LM and CM. Using organ bath system to assess contrctile responses of smooth muscle.
  
  
  RESULTS
  Up4A could induce contractile responses in both CM and LM, which were similar with ATP and UTP. IP5 did not attenuate Up4A could induce contractions in both LM and CM, but suramin and indomethacin significantly inhibited Up4A contraction in CM, but not in LM.
  
  
  CONCLUSIONS
  Our results suggest that extracellular nucleosides and their inhibitors induce different responses between LM and CM.
authors.forename: Wen-Su
authors.initials: WS
authors.lastname: Yuan
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Xu
authors.forename: Meng-Dan
authors.initials: MD
authors.lastname: Liu
authors.forename: Yue-Bing
authors.initials: YB
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Li
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D015226:Dinucleoside Phosphates / Q000494:pharmacology*; D007213:Indomethacin; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology*; D009711:Nucleotides / Q000494:pharmacology*; D051381:Rats; D013498:Suramin; D014544:Uridine Triphosphate / Q000494:pharmacology
chemical_list: D015226:Dinucleoside Phosphates; D009711:Nucleotides; C529314:uridine adenosine tetraphosphate; D013498:Suramin; D000255:Adenosine Triphosphate; D014544:Uridine Triphosphate; D007213:Indomethacin