title: Isoflavanones from Desmodium oxyphyllum and their cytotoxicity.
abstract: Two new isoflavanones, (3R)-7-hydroxy-4'-methoxy-5-methoxycarbonyl-isoflavanone (1) and (3R)-8-hydroxy-4'-methoxy-7-methoxycarbonyl-isoflavanone (2), together with seven known isoflavanones (3-9) were isolated from Desmodium oxyphyllum of the Leguminosae family. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 1 showed good cytotoxicity against NB4 and SHSY5Y cell lines with IC50 values of 3.1 and 2.5 μM; compound 2 exhibited cytotoxicity against PC3 cell lines with a IC50 value of 3.6 μM; compound 4 showed cytotoxicity against A549 and SHSY5Y cell lines with IC50 values of 3.6 and 2.8 μM; and compound 5 displayed cytotoxicity against NB4, SHSY5Y, and MCF7 cell lines with IC50 values of 2.6, 3.8, and 2.8 μM, respectively. Other compounds also showed moderate cytotoxicity for some tested cell lines with IC50 values between 5.4 and 8.8 μM.
authors.affiliation: a School of Pharmacy, Yunnan University of Traditional Chinese Medicine , Kunming 650500 , China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Li
authors.forename: Yin-Ke
authors.initials: YK
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Du
authors.forename: Hai-Yin
authors.initials: HY
authors.lastname: Yang
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Gao
authors.forename: Qiu-Fen
authors.initials: QF
authors.lastname: Hu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D061986:MCF-7 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: C000592294:(3R)-7-hydroxy-4'-methoxy-5-methoxycarbonyl-isoflavanone; C000592295:(3R)-8-hydroxy-4'-methoxy-7-methoxycarbonyl-isoflavanone; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007529:Isoflavones; C065753:isoflavanone
keywords: Desmodium oxyphyllum; cytotoxicity; isoflavanone