title: Novel thermo- and pH-responsive hydroxypropyl cellulose- and poly (L-glutamic acid)-based microgels for oral insulin controlled release.
abstract: Novel smart microgel particles made of poly (L-glutamic acid-2-hydroxylethyl methacrylate) (PGH) and hydroxypropyl cellulose-acrylic acid (HPC-AA) have been successfully prepared via emulsion polymerization. The dynamic light scattering measurement reveals that the average hydrodynamic radius 〈Rh〉 and hydrodynamic radius distributions f (Rh) of the microgel particles depend on the temperature and pH value thus the microgel particles exhibit both pH- and temperature-sensitivity. In vitro release study shows that the amount of insulin released from microgels in the gastric juice (at pH 1.2) is significantly less than that in the intestinal fluid (at pH 6.8). These results indicate that the resultant microgels are of potential for use in intelligent oral drug delivery systems.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, PR China.
authors.forename: Yunyan
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, PR China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, PR China.
authors.forename: Aiping
authors.initials: A
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Changchun 130022, PR China.
authors.forename: Chaoliang
authors.initials: C
authors.lastname: He
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Changchun 130022, PR China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Zhuang
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Changchun 130022, PR China.
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D006358:Hot Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000493:pharmacokinetics; D007328:Insulin / Q000737:chemistry / Q000493:pharmacokinetics; D011099:Polyglutamic Acid / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D003692:Delayed-Action Preparations; D007004:Hypoglycemic Agents; D007328:Insulin; D011099:Polyglutamic Acid; D002482:Cellulose; C008079:hydroxypropylcellulose