title: Convenient generation of quantum dot-incorporated photonic crystal beads for multiplex bioassays.
abstract: Barcode particles have a demonstrated value for multiplexed bioassays in clinical diagnostics, drug discovery, and so on. Attempts to develop this technology are focusing on the generation of novel particles with a large number of identifications to increase the throughput of the assays. Here we report a new type of barcode particles with quantum dot (QD)-photonic crystal (PC) joint spectrum encoding. These barcode particles are simply prepared by in-situ polymerization of CdTe QDs-contained acrylamide pre-gel in the colloidal photonic crystal beads (PCBs). By encapsulating different wavelength-and-intensity QDs into the PCBs with various-reflection spectra, thousands of available barcode particles could be obtained. Moreover, by employing magnetic nanoparticles into the PCBs, the achieved barcode particles could be conferred a function of controllable movement under magnetic field. This feature could significantly increase the sensitivity and simplify the processing of the bioassays.
authors.forename: Yao
authors.initials: Y
authors.lastname: Cheng
authors.forename: Yuanjin
authors.initials: Y
authors.lastname: Zhao
authors.forename: Fengqi
authors.initials: F
authors.lastname: Shangguan
authors.forename: Baofen
authors.initials: B
authors.lastname: Ye
authors.forename: Tingting
authors.initials: T
authors.lastname: Li
authors.forename: Zhongze
authors.initials: Z
authors.lastname: Gu
mesh_terms: D001681:Biological Assay / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008027:Light; D008863:Microspheres; D036103:Nanotechnology / Q000295:instrumentation*; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation*; D045663:Quantum Dots
chemical_list: D020099:Coated Materials, Biocompatible