title: Meta-analysis: narrow band imaging for diagnosis of gastric intestinal metaplasia.
abstract: BACKGROUND
  Distinguishing early gastric cancer is challenging with current imaging techniques. Narrow band imaging (NBI) is effective for characterizing gastric lesions.
  
  
  OBJECTIVE
  The aim of this meta-analysis was to estimate the diagnostic accuracy of NBI in the gastric intestinal metaplasia (GIM).
  
  
  METHODS
  We performed data analysis using Meta-DiSc (version 1.4) and STATA (version 11.0) software. To assess study quality and potential for bias, we used the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool.
  
  
  RESULTS
  Six studies involving 347 patients were included. On a per-patient basis, the sensitivity of NBI for diagnosis of GIM was 0.65 (95% CI  =  0.56-0.74), and the specificity was 0.93 (95% CI  =  0.88-0.97). The area under the summary receiver operating characteristic (SROC) curve was 0.8731. However, on a per-lesion basis, the sensitivity and specificity of NBI were 0.69 (95% CI  =  0.63-0.74) and 0.91 (95% CI  =  0.87-0.94), respectively. The SROC was 0.9009. The pooled sensitivity and specificity of magnification endoscopy (NBI-ME) were 0.76 (95% CI  =  0.61-0.87) and 0.89 (95% CI  =  0.80-0.94), respectively, on per-patient analysis. On a per-lesion basis, the pooled sensitivity and specificity of NBI-ME were 0.84 (95% CI  =  0.76-0.89) and 0.93 (95% CI  =  0.89-0.96), respectively. Heterogeneity was observed with an I2 for diagnostic odds ratio (DOR) of 0.01% and 85.8%, respectively. There was no statistical significance for the evaluation of publication bias.
  
  
  CONCLUSIONS
  Our meta-analysis shows that NBI is a useful tool for differential diagnosis of GIM with relatively low sensitivity and high specificity.
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, P.R.C.
authors.forename: Jia
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, P.R.C.
authors.forename: Jixiang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, P.R.C.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, P.R.C.
authors.forename: Xufeng
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, P.R.C.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, P.R.C.
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, P.R.C.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Dong
mesh_terms: D006801:Humans; D008679:Metaplasia / Q000175:diagnosis; D062048:Narrow Band Imaging / Q000379:methods*; D013272:Stomach Diseases / Q000175:diagnosis* / Q000473:pathology
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