title: Malignant peripheral nerve sheath tumour of the maxilla.
abstract: A 38-year-old man was diagnosed with malignant peripheral nerve sheath tumour of the maxilla. He was treated with total maxillectomy. Histopathological examination of the resected specimen revealed a close resection margin. The tumour was of high grade with an MIB-1 labelling index of almost 60%. At six weeks following the surgery, he developed local tumour relapse. The patient succumbed to the disease at five months from the time of diagnosis. The present report underlines the locally aggressive nature of malignant peripheral nerve sheath tumour of the maxilla which necessitates an early therapeutic intervention. A complete resection with clear margins is the most important prognostic factor for malignant peripheral nerve sheath tumour in the head and neck region. Adjuvant radiotherapy may be considered to improve the local control. Future research may demarcate the role of targeted therapy for patients with malignant peripheral nerve sheath tumour.
authors.affiliation: Department of Radiation Oncology, Dr. B.R.A Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.
authors.forename: Puja
authors.initials: P
authors.lastname: Sahai
authors.affiliation: Department of Radiation Oncology, Dr. B.R.A Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.
authors.forename: Bidhu Kalyan
authors.initials: BK
authors.lastname: Mohanti
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Devajit
authors.initials: D
authors.lastname: Nath
authors.affiliation: Department of Radiation Oncology, Dr. B.R.A Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.
authors.forename: Suman
authors.initials: S
authors.lastname: Bhasker
authors.affiliation: Department of Radiation Oncology, Dr. B.R.A Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.
authors.forename: Subhash
authors.initials: S
authors.lastname: Chander
authors.affiliation: Department of Medical Oncology, Dr. B.R.A Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sameer
authors.initials: S
authors.lastname: Bakhshi
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Chirom Amit
authors.initials: CA
authors.lastname: Singh
references.citation: World J Surg Oncol. 2006 Aug 22;4:55
references.pmid: 16923196
references.citation: Am J Surg Pathol. 2003 Oct;27(10):1337-45
references.pmid: 14508395
references.citation: Cancer. 1977 Oct;40(4):1562-70
references.pmid: 907970
references.citation: Am J Surg. 1992 Apr;163(4):440-2
references.pmid: 1558285
references.citation: Arch Otolaryngol. 1977 Jun;103(6):365-8
references.pmid: 869773
references.citation: Ann Oncol. 2011 Jan;22(1):207-214
references.pmid: 20656792
references.citation: J Clin Oncol. 2005 Nov 20;23(33):8422-30
references.pmid: 16293873
references.citation: J Clin Pathol. 2003 Nov;56(11):826-30
references.pmid: 14600126
references.citation: Laryngoscope. 1991 Oct;101(10):1044-9
references.pmid: 1921630
references.citation: Cancer. 1973 Jan;31(1):184-90
references.pmid: 4683036
references.citation: Cancer. 1986 May 15;57(10):2006-21
references.pmid: 3082508
references.citation: Neuro Oncol. 2013 Feb;15(2):135-47
references.pmid: 23161774
references.citation: Indian J Otolaryngol Head Neck Surg. 1999 Jan;51(1):47-50
references.pmid: 23119484
references.citation: Head Neck. 2007 May;29(5):439-45
references.pmid: 17163467
references.citation: Mol Cancer Ther. 2009 May;8(5):1157-68
references.pmid: 19417153
references.citation: Clin Cancer Res. 2013 Jan 15;19(2):450-61
references.pmid: 23209032
references.citation: J Laryngol Otol. 2000 Feb;114(2):119-24
references.pmid: 10748827