title: Novel pH-sensitive biodegradable polymeric drug delivery systems based on ketal polymers.
abstract: This article reviews the recent developments on novel pH-sensitive ketal-based biodegradable polymeric drug delivery systems. Due to the degradation of ketal derivatives, neutral alcohols and ketones, ketal derivatives can be used to fabricate pH-degradable polymer with pH-degradable ketal linkages in new drug delivery systems by avoiding inflammatory problems. Due to the novelty of ketal polymers, there were few reports about ketal polymers. The review starts with a brief introduction to the pH-sensitive drug delivery system, followed by the structure, preparation and characterization techniques of ketal polymers. Thereafter, the promising applications in various diseases in relation to micro/nano drug carriers based on ketal polymers are summarized and discussed.
authors.forename: Daquan
authors.initials: D
authors.lastname: Chen
authors.forename: Hongbo
authors.initials: H
authors.lastname: Wang
mesh_terms: D020341:Absorbable Implants; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure*; D011108:Polymers / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D053769:Nanocapsules; D011108:Polymers