title: ZnCl2-mediated practical protocol for the synthesis of Amadori ketoses.
abstract: An efficient and practical protocol for the synthesis of Amadori ketoses N-(1-deoxy-D-fructose-1-yl) amino acid (amino acid=L-valine (1), L-leucine (2), L-isoleucine (3), L-tryptophan (4), L-phenylalanine (5), L-arginine (6) has been accomplished by employing ZnCl2 as a catalyst. The developed method circumvents protection and deprotection steps as well as tedious ion-exchange and column chromatographic techniques. The accomplished Amadori ketoses showed moderate to weak angiotensin I converting enzyme (ACE) inhibitory activity.
authors.affiliation: Food Safety and Analytical Quality Control Laboratory, CSIR-CFTRI, KRS Road, Mysore 570020, Karnataka, India. Electronic address: nani.shankar@gmail.com.
authors.forename: Nanishankar V
authors.initials: NV
authors.lastname: Harohally
authors.affiliation: Food Safety and Analytical Quality Control Laboratory, CSIR-CFTRI, KRS Road, Mysore 570020, Karnataka, India.
authors.forename: Sudhanva M
authors.initials: SM
authors.lastname: Srinivas
authors.affiliation: Food Safety and Analytical Quality Control Laboratory, CSIR-CFTRI, KRS Road, Mysore 570020, Karnataka, India.
authors.forename: Sushma
authors.initials: S
authors.lastname: Umesh
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D006801:Humans; D007661:Ketoses / Q000138:chemical synthesis* / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D000806:Angiotensin-Converting Enzyme Inhibitors; D002712:Chlorides; D007661:Ketoses; D017967:Zinc Compounds; C016837:zinc chloride
keywords: ACE; Amadori rearrangement; Zinc