title: The contribution of qualitative CEUS to the determination of malignancy in adnexal masses, indeterminate on conventional US - a multicenter study.
abstract: The aim of this study is to evaluate the efficacy of qualitative analysis of contrast-enhanced ultrasound (CEUS) in discrimination of adnexal masses which were undetermined by conventional ultrasound (US). A total of 120 patients underwent transabdominal CEUS. The initial enhancement time and intensity compared with the uterine myometrium, contrast agent distribution patterns and dynamic changes of enhancement were assessed. The sensitivity (Sen), specificity (Spe), positive predictive value (PPV), negative predictive value (NPV), accuracy (ACC) and Youden's index were calculated for contrast variables. The gold standard was the histological diagnosis. There were 48 malignant tumors and 72 benign tumors. The enhancement features of malignant masses were different from benign ones. Earlier or simultaneous enhancement with inhomogeneous enhancement yielded the highest capability in differential diagnosis, and Sen, Spe, PPV, NPV, ACC, Youden's index was 89.6%, 97.2%, 93.2%, 95.6%, 93.3%, and 0.88, respectively. The qualitative evaluation of CEUS is useful in the differential diagnosis of adnexal masses where conventional US is indeterminate.
authors.affiliation: Department of Ultrasound, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Xinling
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Yongjiang
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Department of Ultrasound, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Rongqin
authors.initials: R
authors.lastname: Zheng
authors.affiliation: Department of Ultrasound, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Department of Ultrasound, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Zeping
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Ultrasound, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Huang
authors.affiliation: Department of Ultrasound, General Hospital of Chinese People's Liberation Army, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, Peking Union Medical College Hospital, Beijing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Dai
authors.affiliation: Department of Ultrasound, Xi Jing Hospital of Fourth Military Medical University, Xi'an, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Ultrasound, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Wen
mesh_terms: D000291:Adnexal Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D000328:Adult; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007089:Image Enhancement; D009369:Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D003287:Contrast Media
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