title: Concomitant ovarian drilling and oocyte retrieval by laparoendoscopic single-site surgery led to live birth using in vitro maturation of oocyte and transfer of frozen-thawed blastocyst in woman with polycystic ovary syndrome.
abstract: This case report describes a case of concomitant ovarian drilling and retrieval of oocytes using laparoendoscopic single-site surgery and the resultant birth of a healthy infant after transfer of frozen-thawed blastocyst from in vitro matured oocyte in a woman with polycystic ovary syndrome. A 33-year-old woman presented with anovulatory, clomiphene-resistant polycystic ovary syndrome, and 1-year history of infertility. Thirty-seven immature oocytes were retrieved and multiperforation of ovaries was performed at the same time by laparoendoscopic single-site surgery. Twenty-three oocytes reached metaphase II after 24-h culture in in vitro maturation medium, which was followed by intracytoplasmic sperm injection. Eventually, seven embryos were vitrified and spontaneous ovulation was restored after the operation. Although the first single frozen-thawed blastocyst transferred in a natural cycle ended up a biochemical pregnancy, the second frozen-thawed blastocyst transfer resulted in successful pregnancy, followed by live birth of a healthy male infant.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hirata
authors.forename: Akihisa
authors.initials: A
authors.lastname: Fujimoto
authors.forename: Kaori
authors.initials: K
authors.lastname: Koga
authors.forename: Osamu
authors.initials: O
authors.lastname: Wada-Hiraike
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Fujii
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Osuga
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010535:Laparoscopy / Q000379:methods*; D050498:Live Birth; D008297:Male; D054315:Oocyte Retrieval / Q000379:methods*; D009865:Oocytes / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000628:therapy*; D011247:Pregnancy
keywords: frozen-thawed embryo transfer; in vitro maturation; laparoendoscopic single-site surgery; laparoscopic ovarian drilling; polycystic ovary syndrome