title: Electrospun nanofiber mat as a protector against the consequences of brain injury.
abstract: Traumatic/surgical brain injury can initiate a cascade of pathological changes that result, in the long run, in severe damage of brain parenchyma and encephalopathy. Excessive scarring can also interfere with brain function and the glial scar formed may hamper the restoration of damaged brain neural pathways. In this preliminary study we aimed to investigate the effect of dressing with an L-lactide-caprolactone copolymer nanofiber net on brain wound healing and the fate of the formed glial scar. Our rat model of surgical brain injury (SBI) of the fronto-temporal region of the sensorimotor cortex imitates well the respective human neurosurgery situation. Brains derived from SBI rats with net-undressed wound showed massive neurodegeneration, entry of systemic inflammatory cells into the brain parenchyma and the astrogliosis due to massive glial scar formation. Dressing of the wound with the nanofiber net delayed and reduced the destructive phenomena. We observed also a reduction in the scar thickness. The observed modification of local inflammation and cicatrization suggest that nanofiber nets could be useful in human neurosurgery.
authors.affiliation: Dorota Sulejczak, Department of Experimental Pharmacology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str., 02-106 Warsaw, Poland, phone: +48 22 608 65 81, fax: +48 22 608 65 90, e-mail: dsulejczak@imdik.pan.pl.
authors.forename: Dorota
authors.initials: D
authors.lastname: Sulejczak
authors.forename: Jarosław
authors.initials: J
authors.lastname: Andrychowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Kowalczyk
authors.forename: Paweł
authors.initials: P
authors.lastname: Nakielski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Frontczak-Baniewicz
authors.forename: Tomasz
authors.initials: T
authors.lastname: Kowalewski
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000473:pathology*; D002921:Cicatrix / Q000473:pathology* / Q000517:prevention & control*; D008297:Male; D057139:Nanofibers / Q000627:therapeutic use*; D011091:Polyesters / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing
chemical_list: D011091:Polyesters; C062968:lactide-caprolactone copolymer