title: Neonatal leukemoid reaction associated with Candida albicans chorioamnionitis.
abstract: Chorioamnionitis due to Candida species is relatively rare, despite the high prevalence (20-25%) of Candida vulvovaginitis during pregnancy. We describe a case of neonatal leukemoid reaction (NLR) associated with Candida albicans chorioamnionitis. A male infant was born at 31 weeks' gestation and weighed 1864 g. Laboratory tests at birth indicated marked leukocytosis (i.e. total leukocyte count 89.8 × 10(9) /L including 66% polymorphonuclear leukocytes and 15% band forms). Samples of the infant's pharyngeal mucus and tracheal aspirate were positive for Candida albicans. On further histopathology of the placenta, C. albicans mycelia had invaded the placenta, chorioamniotic membrane, and umbilical cord. Although it is not very common, C. albicans chorioamnionitis should be considered in preterm infants with NLR.
authors.affiliation: Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital Perinatal Center, Kobe, Japan.
authors.forename: Sota
authors.initials: S
authors.lastname: Iwatani
authors.forename: Masami
authors.initials: M
authors.lastname: Mizobuchi
authors.forename: Toshiki
authors.initials: T
authors.lastname: Sofue
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanaka
authors.forename: Hitomi
authors.initials: H
authors.lastname: Sakai
authors.forename: Seiji
authors.initials: S
authors.lastname: Yoshimoto
authors.forename: Hideto
authors.initials: H
authors.lastname: Nakao
mesh_terms: D002177:Candidiasis; D002821:Chorioamnionitis / Q000382:microbiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007955:Leukemoid Reaction / Q000382:microbiology*; D008297:Male; D011247:Pregnancy
keywords: Candida albicans; chorioamnionitis; genetic amniocentesis; leukemoid reaction; preterm infant