title: The utility of serial plasma sE-selectin measurements in the prediction of retinopathy of prematurity in premature infants.
abstract: BACKGROUND
  sE-selectin has recently been suggested as a surrogate marker for prediction of ROP development.
  
  
  OBJECTIVE
  The possible role of serial plasma sE-selectin measurements in early prediction and diagnosis of ROP was evaluated.
  
  
  METHODS
  Prospective observational study
  
  
  METHODS
  Forty six preterm infants aged <34weeks of gestation and weighing <1500 g were enrolled. Of these, 26 constituted the ROP group and 20 constituted the no-ROP group. sE-selectin levels were measured serially in blood samples on the 1st day and on 14th and 28th postnatal days.
  
  
  METHODS
  The primary outcome measure was to evaluate the role of sE-selectin concentrations in prediction of ROP.
  
  
  RESULTS
  The mean gestational age and birth weight were significantly lower in the ROP group. The mean sE-selectin concentrations in ROP group were significantly greater than those in no-ROP group at each time point (1st, 14th and 28th days of postnatal life). A receiver operating characteristic (ROC) analysis showed that at a plasma concentration of ≥86ng/mL on the 1st postnatal day, sE-selectin had a sensitivity of 100% and a specificity of 94.1% with a positive predictive value of 96.3% and a negative predictive value of 100%. Plasma sE-selectin concentrations were significantly greater in infants who developed ROP in three different time points.
  
  
  CONCLUSIONS
  This study shows for the first time that measurement of plasma sE-selectin concentrations as early as the first day of life might help identify preterm infants at risk of ROP.
authors.affiliation: Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey. Electronic address: drmerih@yahoo.com.
authors.forename: Merih
authors.initials: M
authors.lastname: Çetinkaya
authors.affiliation: Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
authors.forename: Tugba
authors.initials: T
authors.lastname: Erener-Ercan
authors.affiliation: Department of Pharmacology, Uludag University, Faculty of Medicine, Bursa,Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Cansev
authors.affiliation: Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Buyukkale
authors.affiliation: Department of Neonatology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Ferhat
authors.initials: F
authors.lastname: Cekmez
authors.affiliation: Department of Pediatrics, Gulhane Military Medical Faculty, Istanbul, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Aydemir
authors.affiliation: Department of Ophtalmology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
authors.forename: Dilara
authors.initials: D
authors.lastname: Pirhan
authors.affiliation: Department of Pediatrics, Gulhane Military Medical Faculty, Istanbul, Turkey.
authors.forename: Fatih Alparslan
authors.initials: FA
authors.lastname: Genc
authors.affiliation: Department of Pediatrics, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Acar
authors.affiliation: Department of Pediatrics, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
authors.forename: Necati
authors.initials: N
authors.lastname: Taskin
mesh_terms: D019040:E-Selectin / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D011446:Prospective Studies; D012178:Retinopathy of Prematurity / Q000097:blood*
chemical_list: D019040:E-Selectin
keywords: Preterm; Retinopathy of prematurity; sE-selectin