title: Interleukin-6 dynamics as a basis for an early-warning monitor for sepsis and inflammation in individual pigs.
abstract: Static interleukin-6 (IL-6) levels of pigs contain considerable individual differences, which obstruct the practical use of IL-6 for disease monitoring purposes. It was hypothesised that interleukin-6 (IL-6) dynamics could be used to quantify these individual differences and carries critical information of the individual pig infection status. Time series of IL-6 responses in 25 pigs were analysed before and after infection by Actinobacillus pleuropneumoniae. The results indicated that amplitude increases of IL-6 fluctuations of individual pigs rather than static IL-6 values should be used as indicator of the infection state. This study shows the added value for IL-6 time series analyses of individual pigs. These results are a first step towards the development of objective individualised methods for monitoring and early detection of sepsis and inflammation processes in pigs by integrating animal response dynamics.
authors.affiliation: Division Measure, Model & Manage Bioresponses, Department of Biosystems, KU Leuven, Kasteelpark Arenberg 30, B-3001 Leuven, Belgium.
authors.forename: Tim
authors.initials: T
authors.lastname: Tambuyzer
authors.affiliation: Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium.
authors.forename: Tine
authors.initials: T
authors.lastname: De Waele
authors.affiliation: Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium.
authors.forename: Koen
authors.initials: K
authors.lastname: Chiers
authors.affiliation: Division Measure, Model & Manage Bioresponses, Department of Biosystems, KU Leuven, Kasteelpark Arenberg 30, B-3001 Leuven, Belgium.
authors.forename: Daniel
authors.initials: D
authors.lastname: Berckmans
authors.affiliation: Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium.
authors.forename: Bruno M
authors.initials: BM
authors.lastname: Goddeeris
authors.affiliation: Division Measure, Model & Manage Bioresponses, Department of Biosystems, KU Leuven, Kasteelpark Arenberg 30, B-3001 Leuven, Belgium. Electronic address: jean-marie.aerts@biw.kuleuven.be.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Aerts
mesh_terms: D000189:Actinobacillus Infections / Q000097:blood / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D016977:Actinobacillus pleuropneumoniae / Q000276:immunology*; D000818:Animals; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D007249:Inflammation / Q000097:blood / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D015850:Interleukin-6 / Q000097:blood*; D008137:Longitudinal Studies; D012372:ROC Curve; D018805:Sepsis / Q000097:blood / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000276:immunology* / Q000382:microbiology
chemical_list: D015415:Biomarkers; D015850:Interleukin-6
keywords: Disease outcome; Early warning monitoring; IL-6 dynamics; Sepsis and inflammation