title: Early-life cocaine interferes with BDNF-mediated behavioral plasticity.
abstract: An important aspect of goal-directed action selection is differentiating between actions that are more or less likely to be reinforced. With repeated performance or psychostimulant exposure, however, actions can assume stimulus-elicited-or "habitual"-qualities that are resistant to change. We show that selective knockdown of prelimbic prefrontal cortical Brain-derived neurotrophic factor (Bdnf) increases sensitivity to response-outcome associations, blocking habit-like behavioral inflexibility. A history of adolescent cocaine exposure, however, occludes the "beneficial" effects of Bdnf knockdown. This finding highlights a challenge in treating addiction-that drugs of abuse may bias decision-making toward habit systems even in individuals with putative neurobiological resiliencies.
authors.affiliation: Department of Pediatrics, Emory School of Medicine, Atlanta, Georgia 30329, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Hinton
authors.forename: Marina G
authors.initials: MG
authors.lastname: Wheeler
authors.forename: Shannon L
authors.initials: SL
authors.lastname: Gourley
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage*; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D003042:Cocaine / Q000008:administration & dosage*; D003216:Conditioning, Operant / Q000187:drug effects* / Q000502:physiology*; D004334:Drug Administration Schedule; D005508:Food Deprivation; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000378:metabolism; D012055:Reinforcement Schedule
chemical_list: D000779:Anesthetics, Local; D019208:Brain-Derived Neurotrophic Factor; D049452:Green Fluorescent Proteins; D003042:Cocaine
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