title: Thermal analysis study of antihypertensive drugs telmisartan and cilazapril.
abstract: OBJECTIVE
  The aim of the present work is to study the thermal analysis of telmisartan and cilazapril.
  
  
  METHODS
  Thermogravimetry (TGA), derivative thermogravimetry (DTG) and differential thermal analysis (DTA) were used through the work to achieve the thermal analysis study of some antihypertensive drugs, telmisartan and cilazapril.
  
  
  RESULTS
  The results led to thermal stability data and also to the interpretation concerning the thermal decomposition. Thermogravimetry data allowed determination of the kinetic parameters such as, activation energy and frequency factor.
  
  
  CONCLUSIONS
  The simplicity, speed and low operational costs of thermal analysis justify its application in the quality control of pharmaceutical compounds for medications.
authors.affiliation: Faculty of Technology and Development, Zagazig University, Egypt.
authors.forename: Refaat Ahmed
authors.initials: RA
authors.lastname: Saber
authors.affiliation: National Organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt.
authors.forename: Ali Kamal
authors.initials: AK
authors.lastname: Attia
authors.affiliation: National Organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt.
authors.forename: Waheed Mohamed
authors.initials: WM
authors.lastname: Salem
keywords: Antihypertensive; Cilazapril; Drugs; Quality control; Telmisartan; Thermal analysis
references.citation: Adv Pharm Bull. 2013;3(2):419-24
references.pmid: 24312870
references.citation: Eur Heart J. 1999 Jul;20(14):997-1008
references.pmid: 10381851
references.citation: Adv Pharm Bull. 2013;3(1):147-52
references.pmid: 24312828
references.citation: Spectrochim Acta A Mol Biomol Spectrosc. 2005 Mar;61(5):799-805
references.pmid: 15683781
references.citation: J Cardiovasc Pharmacol. 1985 May-Jun;7(3):569-80
references.pmid: 2410692
references.citation: J Med Chem. 1996 Feb 2;39(3):625-56
references.pmid: 8576904
references.citation: J Pharm Biomed Anal. 2005 Apr 29;37(5):949-55
references.pmid: 15862672
references.citation: Drugs. 1991;41 Suppl 1:18-24
references.pmid: 1712267