title: [Evaluation on the efficacy of prevention programs and relevant factors targeting mother-to-infant transmission on hepatitis B virus in Yunnan province].
abstract: OBJECTIVE
  To explore the efficacy of prevention programs and relevant factors targeting mother-to-infant transmission of HBV in Yunnan province.
  
  
  METHODS
  In Yunnan province, we selected HBsAg positive pregnant women that delivered in hospital from January 1st through June 30th, 2011. Newborns of these pregnant women were under PMTCT (prevention of mother to child treatment) program and followed. Every infant was drawn 2 ml venous blood and questionnaire survey was carried out when the baby was 7-12 month-old and completed the vaccination processes. Serum samples of them were then collected and detected on the 5 serological indicators of HBV.
  
  
  RESULTS
  were analyzed statistically.
  
  
  RESULTS
  There were 2 765 infants in the study program. The success rate of PMTCT was 95.88% . Rates of coverage on both timely-birth dose and 3 doses of HepB were 97.03% and 92.30% respectively. The overall vaccinated rate and timely-birth vaccinated rate on hepatitis B immunoglobulin (HBIG) were 68.97% and 94.49% respectively. The success rate of PMTCT was 97.16% after administration of passive-active immune-prophylaxis (HepB and HBIG), compared to the rate as 93.01% when vaccinated with HepB only. Significant differences were seen in the successful rates of PMTCT between combined and non-combined immunization. Either the combined or non-combined immunization, there were significant differences seen in the success rates of PMTCT regardless the positivity status of HBsAg or HBeAg, among the infected mothers.
  
  
  CONCLUSIONS
  The efficacy of passive-active immune-prophylaxis program seemed to be better than the one without combined immunization. It was vitally important for the infants whose mothers' HBsAg and HBeAg status were positive, to receive regular and timely combined immunization. In order to promote the PMTCT in Yunnan province, vaccinated rate on HBIG should be further improved.
authors.affiliation: Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
authors.forename: Wenyu
authors.initials: W
authors.lastname: Kang
authors.affiliation: Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China. Email: lulin.07@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention.
authors.forename: Liping
authors.initials: L
authors.lastname: Shen
authors.affiliation: Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
authors.forename: Zhixian
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
authors.forename: Guofei
authors.initials: G
authors.lastname: Huang
authors.affiliation: Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.affiliation: Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Kong
mesh_terms: D002681:China / Q000453:epidemiology; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000517:prevention & control*; D006515:Hepatitis B virus; D006801:Humans; D007114:Immunization; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D009035:Mothers; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control