title: A novel therapeutic approach for the treatment of central sleep apnea: The remedē® system.
abstract: Central sleep apnea (CSA) occurs primarily in cardiovascular patients and is associated with high morbidity and mortality. The disorder often is unrecognized due to the overlap of symptoms with those of the underlying cardiac disease. CSA can be easily diagnosed with a sleep study. Following optimization of all co-morbidities, the therapeutic approach available currently focuses on mask-based therapies which suffer from poor patient adherence. A new therapy, the remedē® System, has been developed; it utilizes a transvenous, fully implantable system providing phrenic nerve stimulation intended to restore a more normal breathing pattern. The therapy demonstrated promising results based on an initial chronic study and a randomized trial is underway to further evaluate safety and efficacy of this novel system in patients with CSA.
authors.affiliation: University of Oklahoma School of Medicine. Electronic address: rgermany@respicardia.com.
authors.forename: Robin
authors.initials: R
authors.lastname: Germany
authors.affiliation: Washington University School of Medicine.
authors.forename: Susan
authors.initials: S
authors.lastname: Joseph
authors.affiliation: Respicardia, Inc.
authors.forename: Kristofer
authors.initials: K
authors.lastname: James
authors.affiliation: University of Missouri School of Medicine, Kansas City; St. Luke's Mid-America Heart Institute.
authors.forename: Andrew
authors.initials: A
authors.lastname: Kao
mesh_terms: D003964:Diaphragm / Q000294:innervation*; D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D010791:Phrenic Nerve / Q000503:physiopathology*; D015656:Respiratory Mechanics; D020182:Sleep Apnea, Central / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome
keywords: Central sleep apnea; Heart failure; Phrenic nerve stimulation