title: Modulation of tolerogenic dendritic cells and autoimmunity.
abstract: A key function of dendritic cells (DCs) is to induce either immune tolerance or immune activation. Many new DC subsets are being recognized, and it is now clear that each DC subset has a specialized function. For example, different DC subsets may express different cell surface molecules and respond differently to activation by secretion of a unique cytokine profile. Apart from intrinsic differences among DC subsets, various immune modulators in the microenvironment may influence DC function; inappropriate DC function is closely related to the development of immune disorders. The most exciting recent advance in DC biology is appreciation of human DC subsets. In this review, we discuss functionally different mouse and human DC subsets both in lymphoid organs and non-lymphoid organs, the molecules that regulate DC function, and the emerging understanding of the contribution of DCs to autoimmune diseases.
authors.affiliation: The Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, United States.
authors.forename: Sun Jung
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: The Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, United States. Electronic address: Bdiamond@nshs.edu.
authors.forename: Betty
authors.initials: B
authors.lastname: Diamond
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D001854:Bone Marrow Cells / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation / Q000276:immunology*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D018448:Models, Immunological; D014157:Transcription Factors / Q000276:immunology / Q000378:metabolism
chemical_list: D016207:Cytokines; D014157:Transcription Factors
keywords: Autoimmunity; Dendritic cells; Tissue-resident dendritic cells; Tolerogenic dendritic cells
references.citation: Nat Immunol. 2008 Apr;9(4):405-14
references.pmid: 18327259
references.citation: J Immunol. 2009 Apr 15;182(8):4994-5002
references.pmid: 19342679
references.citation: Eur J Immunol. 2011 Sep;41(9):2585-95
references.pmid: 21660938
references.citation: Blood. 2012 Jan 19;119(3):756-66
references.pmid: 22031862
references.citation: Immunity. 2008 Jul 18;29(1):138-49
references.pmid: 18599325
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5282-7
references.pmid: 19289835
references.citation: PLoS One. 2012;7(7):e41050
references.pmid: 22815909
references.citation: Science. 2000 Dec 15;290(5499):2152-4
references.pmid: 11118150
references.citation: Nat Immunol. 2010 Feb;11(2):141-7
references.pmid: 19946272
references.citation: J Biol Chem. 2007 Sep 28;282(39):28929-28938
references.pmid: 17660297
references.citation: J Exp Med. 2002 Dec 2;196(11):1415-25
references.pmid: 12461077
references.citation: J Exp Med. 2009 Aug 31;206(9):1853-62
references.pmid: 19667061
references.citation: J Immunol. 2004 Jul 1;173(1):307-13
references.pmid: 15210788
references.citation: Blood. 2010 Dec 23;116(26):5885-94
references.pmid: 20852130
references.citation: J Exp Med. 2010 Apr 12;207(4):823-36
references.pmid: 20351058
references.citation: J Immunol. 2010 Oct 15;185(8):4738-49
references.pmid: 20844193
references.citation: Nat Immunol. 2006 Jun;7(6):663-71
references.pmid: 16680143
references.citation: J Immunol. 2008 Oct 15;181(8):5194-8
references.pmid: 18832670
references.citation: Eur J Immunol. 2004 Jan;34(1):221-30
references.pmid: 14971048
references.citation: J Immunol. 2007 Apr 15;178(8):5182-91
references.pmid: 17404301
references.citation: J Exp Med. 1981 Jun 1;153(6):1666-71
references.pmid: 6942092
references.citation: Immunity. 2012 Jun 29;36(6):1031-46
references.pmid: 22749353
references.citation: J Immunol. 2010 Jun 1;184(11):6053-9
references.pmid: 20410487
references.citation: Eur J Immunol. 2005 Jul;35(7):2184-90
references.pmid: 15915542
references.citation: Nat Rev Immunol. 2007 Oct;7(10):817-23
references.pmid: 17767193
references.citation: Immunity. 1999 Dec;11(6):753-61
references.pmid: 10626897
references.citation: Cell. 2007 Oct 5;131(1):33-45
references.pmid: 17923086
references.citation: J Immunol. 2005 Dec 15;175(12):8392-400
references.pmid: 16339581
references.citation: Cell. 2010 Oct 29;143(3):416-29
references.pmid: 21029863
references.citation: Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3012-7
references.pmid: 22315415
references.citation: Cell. 2009 Nov 13;139(4):693-706
references.pmid: 19878981
references.citation: J Immunol. 2007 Jan 1;178(1):271-9
references.pmid: 17182564
references.citation: Adv Immunol. 2010;108:111-65
references.pmid: 21056730
references.citation: Immunology. 2006 Feb;117(2):280-6
references.pmid: 16423064
references.citation: Nat Immunol. 2009 May;10(5):504-13
references.pmid: 19363483
references.citation: Gut. 2010 May;59(5):595-604
references.pmid: 20427394
references.citation: J Immunol. 2010 Nov 15;185(10):6226-33
references.pmid: 20937844
references.citation: J Immunol. 2009 Dec 1;183(11):7039-46
references.pmid: 19915049
references.citation: Immunity. 2009 Sep 18;31(3):502-12
references.pmid: 19733097
references.citation: Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2735-40
references.pmid: 19193853
references.citation: Blood. 2001 Jun 1;97(11):3333-41
references.pmid: 11369621
references.citation: Exp Hematol. 2010 Aug;38(8):629-640.e1
references.pmid: 20399246
references.citation: J Immunol. 2010 Dec 15;185(12):7244-51
references.pmid: 21068402
references.citation: Blood. 2001 Jun 1;97(11):3470-7
references.pmid: 11369639
references.citation: N Engl J Med. 2011 Jul 14;365(2):127-38
references.pmid: 21524210
references.citation: J Exp Med. 2009 Jan 16;206(1):69-78
references.pmid: 19139170
references.citation: Immunity. 2009 Sep 18;31(3):513-25
references.pmid: 19733489
references.citation: Immunity. 2003 Jul;19(1):71-82
references.pmid: 12871640
references.citation: J Immunol. 2010 Jul 1;185(1):400-9
references.pmid: 20530258
references.citation: J Exp Med. 2010 Jun 7;207(6):1261-71
references.pmid: 20479117
references.citation: J Immunol. 2000 Dec 1;165(11):6037-46
references.pmid: 11086035
references.citation: Nat Genet. 2009 Nov;41(11):1228-33
references.pmid: 19838195
references.citation: FEBS Lett. 2000 Dec 15;486(3):261-6
references.pmid: 11119715
references.citation: J Exp Med. 2005 Oct 3;202(7):919-29
references.pmid: 16186184
references.citation: PLoS One. 2009 Dec 30;4(12):e8508
references.pmid: 20041145
references.citation: J Exp Med. 2012 Jun 4;209(6):1153-65
references.pmid: 22615130
references.citation: J Exp Med. 2009 Dec 21;206(13):3115-30
references.pmid: 20008528
references.citation: J Exp Med. 2010 Jun 7;207(6):1247-60
references.pmid: 20479116
references.citation: J Exp Med. 2002 Oct 21;196(8):1099-104
references.pmid: 12391021
references.citation: Annu Rev Immunol. 2011;29:163-83
references.pmid: 21219184
references.citation: Immunity. 2011 Jun 24;34(6):932-46
references.pmid: 21636296
references.citation: J Exp Med. 2011 Oct 24;208(11):2193-9
references.pmid: 21948081
references.citation: Immunity. 2008 Dec 19;29(6):986-97
references.pmid: 19062318
references.citation: FASEB J. 2004 Sep;18(12):1439-41
references.pmid: 15247147
references.citation: J Biol Chem. 2010 Jul 2;285(27):20940-51
references.pmid: 20435889
references.citation: Arthritis Rheum. 2007 Jun;56(6):1910-20
references.pmid: 17530636
references.citation: Science. 2006 Jan 6;311(5757):83-7
references.pmid: 16322423
references.citation: J Exp Med. 2000 Nov 6;192(9):1213-22
references.pmid: 11067871
references.citation: Ann Rheum Dis. 2011 Jul;70(7):1330-7
references.pmid: 21622776
references.citation: Cell. 2002 Jul 26;110(2):191-202
references.pmid: 12150927
references.citation: J Immunol. 2005 Oct 1;175(7):4706-14
references.pmid: 16177118
references.citation: J Immunol. 2010 Mar 1;184(5):2638-45
references.pmid: 20124100
references.citation: J Immunol. 2007 Feb 15;178(4):2579-88
references.pmid: 17277168
references.citation: Blood. 2003 Jul 15;102(2):601-4
references.pmid: 12649155
references.citation: Immunity. 2005 Apr;22(4):439-50
references.pmid: 15845449
references.citation: Gut. 2012 Aug;61(8):1154-62
references.pmid: 22068168
references.citation: Nat Med. 2007 May;13(5):579-86
references.pmid: 17417651
references.citation: Curr Opin Immunol. 2012 Dec;24(6):665-70
references.pmid: 22999705
references.citation: Adv Exp Med Biol. 2007;601:113-9
references.pmid: 17712998
references.citation: Science. 2004 Jan 2;303(5654):83-6
references.pmid: 14657504
references.citation: Immunity. 2013 Apr 18;38(4):729-41
references.pmid: 23562161
references.citation: Curr Opin Immunol. 1998 Dec;10(6):649-55
references.pmid: 9914214
references.citation: J Biol Chem. 2010 Jul 2;285(27):20492-8
references.pmid: 20435894
references.citation: Ann N Y Acad Sci. 2003 Apr;987:249-57
references.pmid: 12727647
references.citation: Blood. 2007 Nov 15;110(10):3793-803
references.pmid: 17687106
references.citation: Mol Immunol. 2011 May;48(9-10):1128-38
references.pmid: 21429584
references.citation: Blood. 2009 Jul 9;114(2):404-14
references.pmid: 19398721
references.citation: Blood. 2010 Mar 11;115(10):1958-68
references.pmid: 20068222
references.citation: J Exp Med. 2012 Jun 4;209(6):1167-81
references.pmid: 22565823
references.citation: Arthritis Rheum. 2010 Jan;62(1):234-44
references.pmid: 20039395
references.citation: J Immunol. 2005 Oct 15;175(8):4839-46
references.pmid: 16210585
references.citation: BMC Immunol. 2009 Jan 27;10:5
references.pmid: 19173720
references.citation: J Exp Med. 2000 Dec 4;192(11):1545-52
references.pmid: 11104797
references.citation: Nature. 1992 Nov 19;360(6401):258-61
references.pmid: 1279441
references.citation: EMBO Rep. 2004 Aug;5(8):825-30
references.pmid: 15272298
references.citation: J Immunol. 2002 Aug 1;169(3):1228-35
references.pmid: 12133943
references.citation: Oncogene. 2008 Aug 7;27(34):4712-23
references.pmid: 18408758
references.citation: Nature. 1996 Sep 5;383(6595):81-5
references.pmid: 8779719
references.citation: Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5360-5
references.pmid: 21402950
references.citation: J Biol Chem. 2011 Mar 11;286(10):7893-7904
references.pmid: 21216962
references.citation: J Exp Med. 1994 Apr 1;179(4):1109-18
references.pmid: 8145033
references.citation: J Exp Med. 2009 Mar 16;206(3):549-59
references.pmid: 19237601
references.citation: J Immunol. 2004 Sep 15;173(6):3844-54
references.pmid: 15356132
references.citation: Blood. 2011 Jun 9;117(23):6172-83
references.pmid: 21474672
references.citation: Immunity. 2004 Nov;21(5):643-53
references.pmid: 15539151
references.citation: J Clin Invest. 2013 Feb;123(2):823-33
references.pmid: 23298838
references.citation: Eur J Immunol. 2007 Oct;37(10):2803-11
references.pmid: 17899552
references.citation: Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20377-81
references.pmid: 19918052
references.citation: J Leukoc Biol. 2006 Jul;80(1):87-95
references.pmid: 16617159
references.citation: J Exp Med. 2009 Mar 16;206(3):561-76
references.pmid: 19221396
references.citation: Science. 2009 Apr 17;324(5925):392-7
references.pmid: 19286519
references.citation: Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15136-41
references.pmid: 17018642
references.citation: J Immunol. 2009 Jan 15;182(2):1107-18
references.pmid: 19124754
references.citation: Mol Cell Biol. 2003 Jan;23(1):26-37
references.pmid: 12482958
references.citation: Blood. 2012 Jun 21;119(25):6052-62
references.pmid: 22442345
references.citation: Cell Mol Immunol. 2008 Feb;5(1):9-21
references.pmid: 18318990
references.citation: Nat Med. 2011 Nov 13;17(12):1663-7
references.pmid: 22081022
references.citation: Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3160-7
references.pmid: 23093673
references.citation: Arthritis Rheum. 2009 Oct;60(10):3081-90
references.pmid: 19790049
references.citation: PLoS Pathog. 2009 Jun;5(6):e1000494
references.pmid: 19557162
references.citation: Blood. 2012 Aug 9;120(6):1228-36
references.pmid: 22700724
references.citation: Nat Immunol. 2009 Apr;10(4):394-402
references.pmid: 19252492
references.citation: J Immunol. 2007 Oct 15;179(8):5082-9
references.pmid: 17911593
references.citation: J Exp Med. 2008 Sep 29;205(10):2437-48
references.pmid: 18809711
references.citation: J Immunol. 2011 Oct 15;187(8):3911-7
references.pmid: 21969315
references.citation: J Exp Med. 2007 Aug 6;204(8):1757-64
references.pmid: 17620361
references.citation: EMBO J. 2009 Feb 4;28(3):274-85
references.pmid: 19153607
references.citation: Immunol Rev. 2007 Dec;220:35-46
references.pmid: 17979838
references.citation: Immunity. 2009 Aug 21;31(2):220-31
references.pmid: 19699171
references.citation: J Exp Med. 2002 Aug 19;196(4):517-27
references.pmid: 12186843
references.citation: Cell. 2004 Jan 23;116(2):281-97
references.pmid: 14744438
references.citation: Immunity. 2005 Jun;22(6):717-28
references.pmid: 15963786
references.citation: Am J Respir Cell Mol Biol. 2010 Feb;42(2):190-9
references.pmid: 19372244
references.citation: J Immunol. 1999 Aug 1;163(3):1409-19
references.pmid: 10415041
references.citation: PLoS One. 2008;3(11):e3694
references.pmid: 19002258
references.citation: Nat Immunol. 2010 Sep;11(9):799-805
references.pmid: 20711193
references.citation: Mol Immunol. 2010 Nov-Dec;48(1-3):333-40
references.pmid: 20822813
references.citation: Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7113-8
references.pmid: 19359473
references.citation: J Immunol. 2011 Jan 1;186(1):255-63
references.pmid: 21131418
references.citation: Immunity. 2010 Dec 14;33(6):967-78
references.pmid: 21167752
references.citation: Immunity. 2003 Jul;19(1):59-70
references.pmid: 12871639
references.citation: Immunol Rev. 2010 Mar;234(1):142-62
references.pmid: 20193017
references.citation: J Exp Med. 2012 Jun 4;209(6):1135-52
references.pmid: 22615127
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12481-6
references.pmid: 16885212
references.citation: Genome Biol. 2008 Jan 24;9(1):R17
references.pmid: 18218067
references.citation: Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11942-7
references.pmid: 20547845
references.citation: Blood. 2006 Apr 1;107(7):2846-54
references.pmid: 16339401
references.citation: Nat Immunol. 2007 Jun;8(6):578-83
references.pmid: 17450143
references.citation: Blood. 2012 Mar 1;119(9):2003-12
references.pmid: 22238324