title: Antioxidant marine algae phlorotannins and radioprotection: a review of experimental evidence.
abstract: Radiation has been widely used for cancer therapy in human medicine. However, the side effects of radiation are problematic and can limit its application. Radiation generates reactive oxygen species, leading to cell death via multiple signaling pathways. The blocking of certain signaling cascades using antioxidants represents a compensatory therapy of radiation-induced tissue injury. Although synthetic chemicals have been investigated in recent decades, anti-oxidants from natural resources have been searched for continuously. Among them, phlorotannins from marine algae, including Ecklonia cava, have been shown to protect cells from radiation-induced injury as well as oxidative stress. In the present review, the radioprotective capacity of phlorotannins derived from marine algae and the mechanisms involved are discussed.
authors.affiliation: Laboratory of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 690-756, South Korea; Institute for Nuclear Science and Technology, Jeju National University, Jeju 690-756, South Korea. Electronic address: shint@jejunu.ac.kr.
authors.forename: Taekyun
authors.initials: T
authors.lastname: Shin
authors.affiliation: College of Medicine, Jeju National University, Jeju 690-756, South Korea.
authors.forename: Meejung
authors.initials: M
authors.lastname: Ahn
authors.affiliation: Institute for Nuclear Science and Technology, Jeju National University, Jeju 690-756, South Korea; Department of Biochemistry, College of Medicine, Jeju National University, Jeju 690-756, South Korea.
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Hyun
authors.affiliation: Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, South Korea.
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, South Korea. Electronic address: moonc@chonnam.ac.kr.
authors.forename: Changjong
authors.initials: C
authors.lastname: Moon
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D059001:Aquatic Organisms / Q000737:chemistry / Q000502:physiology* / Q000528:radiation effects*; D000459:Phaeophyceae / Q000737:chemistry / Q000502:physiology* / Q000528:radiation effects*; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000528:radiation effects
chemical_list: D000975:Antioxidants; D011837:Radiation-Protective Agents
keywords: Brown seaweed; Gamma ray irradiation; Marine algae; Oxidative stress; Phlorotannin