title: Cohort Profile: The Malaysian Cohort (TMC) project: a prospective study of non-communicable diseases in a multi-ethnic population.
abstract: The Malaysian Cohort study was initiated in 2005 by the Malaysian government. The top-down approach to this population-based cohort study ensured the allocation of sufficient funding for the project which aimed to recruit 100,000 individuals aged 35-70 years. Participants were recruited from rural and urban areas as well as from various socioeconomic groups. The main objectives of the study were to identify risk factors, to study gene-environment interaction and to discover biomarkers for the early detection of cancers and other diseases. At recruitment, a questionnaire-based interview was conducted, biophysical measurements were performed and biospecimens were collected, processed and stored. Baseline investigations included fasting blood sugar, fasting lipid profile, renal profile and full blood count. From April 2006 to the end of September 2012 we recruited a total of 106,527 participants. The baseline prevalence data showed 16.6% participants with diabetes, 46.5% with hypertension, 44.9% with hypercholesterolaemia and 17.7% with obesity. The follow-up phase commenced in June 2013. This is the most comprehensive and biggest cohort study in Malaysia, and has become a valuable resource for epidemiological and biological research. For information on collaboration and also data access, investigators can contact the project leader at (rahmanj@ppukm.ukm.edu.my).
authors.affiliation: UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia rahmanj@ppukm.ukm.edu.my.
authors.forename: Rahman
authors.initials: R
authors.lastname: Jamal
authors.affiliation: UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia.
authors.forename: Syed Zulkifli
authors.initials: SZ
authors.lastname: Syed Zakaria
authors.affiliation: UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia.
authors.forename: Mohd Arman
authors.initials: MA
authors.lastname: Kamaruddin
authors.affiliation: UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia.
authors.forename: Nazihah
authors.initials: N
authors.lastname: Abd Jalal
authors.affiliation: UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia.
authors.forename: Norliza
authors.initials: N
authors.lastname: Ismail
authors.affiliation: UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia.
authors.forename: Norkhamiwati
authors.initials: N
authors.lastname: Mohd Kamil
authors.affiliation: UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia.
authors.forename: Noraidatulakma
authors.initials: N
authors.lastname: Abdullah
authors.affiliation: UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia.
authors.forename: Norhafizah
authors.initials: N
authors.lastname: Baharudin
authors.affiliation: UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia.
authors.forename: Noor Hamidah
authors.initials: NH
authors.lastname: Hussin
authors.affiliation: UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia.
authors.forename: Hanita
authors.initials: H
authors.lastname: Othman
authors.affiliation: UKM Medical Molecular Biology Institute (UMBI), Department of Paediatrics, Faculty of Medicine, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia and Malaysia Genome Institute, Bangi, Selangor, Malaysia.
authors.forename: Nor Muhammad
authors.initials: NM
authors.lastname: Mahadi
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D002423:Cause of Death; D002908:Chronic Disease / Q000208:ethnology* / Q000401:mortality; D003920:Diabetes Mellitus / Q000208:ethnology / Q000401:mortality; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D006937:Hypercholesterolemia / Q000208:ethnology / Q000401:mortality; D006973:Hypertension / Q000208:ethnology / Q000401:mortality; D008296:Malaysia / Q000453:epidemiology / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000208:ethnology / Q000401:mortality; D009765:Obesity / Q000208:ethnology / Q000401:mortality; D015995:Prevalence; D011446:Prospective Studies; D012111:Residence Characteristics / Q000706:statistics & numerical data; D012423:Rural Health / Q000706:statistics & numerical data; D017678:Sex Distribution; D012959:Socioeconomic Factors; D014504:Urban Health / Q000706:statistics & numerical data
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