title: The TRPV4 channel.
abstract: The widely distributed TRPV4 cationic channel participates in the transduction of both physical (osmotic, mechanical, and heat) and chemical (endogenous, plant-derived, and synthetic ligands) stimuli. In this chapter we will review TRPV4 expression, biophysics, structure, regulation, and interacting partners as well as physiological and pathological insights obtained in TRPV4 animal models and human genetic studies.
authors.affiliation: Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Garcia-Elias
authors.forename: Sanela
authors.initials: S
authors.lastname: Mrkonjić
authors.forename: Carole
authors.initials: C
authors.lastname: Jung
authors.forename: Carlos
authors.initials: C
authors.lastname: Pardo-Pastor
authors.forename: Rubén
authors.initials: R
authors.lastname: Vicente
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Valverde
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008564:Membrane Potentials; D018345:Mice, Knockout; D011487:Protein Conformation; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D050916:TRPV Cation Channels / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
chemical_list: D050916:TRPV Cation Channels; C416986:TRPV4 protein, human; C486576:Trpv4 protein, mouse