title: New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer.
abstract: Gastric cancer is one of the most frequent cancers, and it ranks the third most common cancer in China. The most recently caudal-related homeobox transcription factor 2 (CDX2) is expressed in a large number of human gastrointestinal cancers. In addition, gastric epithelial cell mutations in CDX2 result in tumor promotion, which is characterized by cellular drug resistance and a high proclivity for developing cancer. A series of publications over the past years suggests a mechanism by which CDX2 overexpression results in multidrug resistance. CDX2 appears to forward control regenerating IV and the multidrug resistance 1 expression signaling pathway for regulation of cell drug resistance.
authors.affiliation: Lin-Hai Yan, Wei-Yuan Wei, Qiang Xiao, Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Lin-Hai
authors.initials: LH
authors.lastname: Yan
authors.affiliation: Lin-Hai Yan, Wei-Yuan Wei, Qiang Xiao, Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Wei-Yuan
authors.initials: WY
authors.lastname: Wei
authors.affiliation: Lin-Hai Yan, Wei-Yuan Wei, Qiang Xiao, Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Yu-Bo
authors.initials: YB
authors.lastname: Xie
authors.affiliation: Lin-Hai Yan, Wei-Yuan Wei, Qiang Xiao, Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xiao
mesh_terms: D017209:Apoptosis; D000071616:CDX2 Transcription Factor; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007422:Intestines / Q000473:pathology; D009154:Mutation; D009857:Oncogenes; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D018398:Homeodomain Proteins
keywords: Apoptosis; Caudal-related homeobox transcription factor 2; Drug resistance; Gastric cancer; Intestinal metaplasia
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