title: Randomized, controlled comparison of advanced hemostatic pads in hepatic surgical models.
abstract: Blood loss during hepatic surgery leads to poor patient outcomes. This study investigates the hemostatic efficacy of a novel sealing hemostatic pad (polyethylene glycol-coated collagen, PCC) and a fibrin sealant pad (fibrin-thrombin coated collagen, FTC) in a leporine hepatic segmentectomy and a porcine hepatic abrasion model. A segmentectomy was used to compare hemostatic success and hematoma incidence in 20 rabbits (10/group). Hepatic abrasions were used to compare hemostatic success up to 10 min after application in six pigs (42 lesions/group). In the segmentectomy model, PCC achieved 100% hemostatic success within 2 min (95% CI: 72.3% to 100%) and FTC achieved 80% hemostatic success within 3 min (49.0% to 94.3%). PCC had lower hematoma incidence at 15 min (0.0 versus 11.1%) and 24 h (20.0 versus 66.7%). In the abrasion model, PCC provided superior hemostatic success at 3 (odds ratio: 24.8, 95% CI: 8.86 to 69.2, P < 0.001), 5 (66.3, 28.5 to 153.9, P < 0.001), 7 (177.5, 64.4 to 489.1, P < 0.001), and 10 min (777.6, 148.2 to 4078, P < 0.001) leading to statistically significant less blood loss. The novel sealing hemostat provides faster and more sustained hemostasis than a fibrin sealant pad in a leporine hepatic segmentectomy and a porcine hepatic abrasion model of hepatic surgery.
authors.affiliation: Baxter Healthcare Corporation, One Baxter Parkway, Deerfield, IL 60015, USA.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Lewis
authors.affiliation: Baxter Healthcare Corporation, One Baxter Parkway, Deerfield, IL 60015, USA.
authors.forename: Jeff
authors.identifier: 0000-0002-4367-6508
authors.initials: J
authors.lastname: McKee
authors.affiliation: Baxter Innovations GmbH, Industriestraße 67, 1221 Vienna, Austria.
authors.forename: Alexandra
authors.identifier: 0000-0003-4936-5847
authors.initials: A
authors.lastname: Schiviz
authors.affiliation: Baxter Innovations GmbH, Industriestraße 67, 1221 Vienna, Austria.
authors.forename: Alexander
authors.identifier: 0000-0003-4836-8579
authors.initials: A
authors.lastname: Bauer
authors.affiliation: Baxter Innovations GmbH, Industriestraße 67, 1221 Vienna, Austria.
authors.forename: Martin
authors.identifier: 0000-0003-2419-4324
authors.initials: M
authors.lastname: Wolfsegger
authors.affiliation: Baxter Innovations GmbH, Industriestraße 67, 1221 Vienna, Austria.
authors.forename: Andreas
authors.identifier: 0000-0002-0780-1332
authors.initials: A
authors.lastname: Goppelt
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