title: The role of Notch pathway in cardiovascular diseases.
abstract: The recent increase in human lifespan, coupled with unhealthy diets and lifestyles have led to an unprecedented increase in cardiovascular diseases. Even in the presence of a wide range of therapeutic options with variable efficacy, mortality due to heart failure is still high and there is a need to identify new therapeutic targets. Genetic and in vitro studies have implicated the Notch signalling in the development and maintenance of the cardiovascular system through a direct effect on biological functions of vascular cells (endothelial and vascular smooth muscle cells) and cardiomyocytes. Notch signalling is also involved in the modulation of inflammation, which plays a major role in causing and exacerbating cardiovascular diseases. The Notch pathway could represent a new therapeutic target for the treatment of cardiovascular diseases.
authors.affiliation: Chair of Cardiology and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Aquila
authors.affiliation: Chair of Cardiology and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.
authors.forename: Micaela
authors.initials: M
authors.lastname: Pannella
authors.affiliation: Chair of Cardiology and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.
authors.forename: Marco Bruno
authors.initials: MB
authors.lastname: Morelli
authors.affiliation: Chair of Cardiology and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Caliceti
authors.affiliation: Chair of Cardiology and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Fortini
authors.affiliation: Chair of Cardiology and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Rizzo
authors.affiliation: Chair of Cardiology and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ferrari
keywords: apoptosis; atherosclerosis; cardiomyocytes; cardiotoxicity; endothelial cells; heart failure
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