title: Hypolipidaemic and antioxidant properties of ethanol extract from Flos populi.
abstract: This study was undertaken to evaluate antihyperlipidaemic and in vitro antioxidant activity of ethanolic extract of Flos populi (EFP). The results demonstrated that EFP contains 78.5% flavonoids and 10.4% phenolics, and it exhibited free radical-scavenging activity on 2,2-diphenyl-picrylhydrazyl (IC50 36.40 ± 0.62 μg/mL) and high reducing power (EC50 206.32 ± 1.6l μg/mL) under in vitro chemical assays. And irrespective of prophylactic administration or remedial administration, in high fat diet-induced hyperlipidaemic mice, oral treatment with EFP produced a decrease in the levels of serum total cholesterol, triglycerides, low-density lipoprotein-cholesterol and increase in high-density lipoprotein-cholesterol. In a word, in high fat diet-fed hyperlipidaemic mice, EFP (100, 200 and 400 mg/kg) significantly altered the plasma lipid levels to near normal. These results support a potential effect of EFP in cardiovascular disease.
authors.affiliation: a College of Chinese Medicinal Materials, Jilin Agriculture University , Changchun , 130118 , Jilin , P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Guosheng
authors.initials: G
authors.lastname: Tang
authors.forename: Enbo
authors.initials: E
authors.lastname: Cai
authors.forename: Shuangli
authors.initials: S
authors.lastname: Liu
authors.forename: Lianxue
authors.initials: L
authors.lastname: Zhang
authors.forename: Shijie
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat; D000431:Ethanol; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D051379:Mice; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology*; D010851:Picrates / Q000494:pharmacology; D032107:Populus / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005419:Flavonoids; D000960:Hypolipidemic Agents; D010636:Phenols; D010851:Picrates; D014280:Triglycerides; D000431:Ethanol; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Flos populi; antioxidant; flavonoids; hypolipidaemic; phenols