title: Dynamics of blood count after rheohemapheresis in age-related macular degeneration: possible association with clinical changes.
abstract: BACKGROUND
  Rheohemapheresis (RHF) is a method that can stop the activity of the dry form of age-related macular degeneration (AMD). The pathophysiologic mechanisms are not well understood, and the effects of the RHF procedures extend beyond the time of the individual procedures.
  
  
  METHODS
  We present the data for 46 patients with AMD treated with a series of 8 rheohemapheretic procedures. Blood count parameters were measured before the first and the last procedures. The clinical effect was judged by changes in the drusenoid pigment epithelium detachment (DPED) area before and after the rheopheretic sessions.
  
  
  RESULTS
  Rheopheresis caused a decrease in hemoglobin (P<0.001), a decrease in leukocytes (P<0.034), and an increase in platelets (P<0.005). We found a negative correlation between the amount of platelets and their volume (P<0.001, Pearson correlation coefficient: -0.509). We identified the platelet/MPV ratio as a good predictor of the clinical outcome. Patients with a platelet/MPV ratio greater than 21.5 (before the last rheopheresis) had a significantly better outcome (P=0.003, sensitivity of 76.9% and specificity of 80%).
  
  
  CONCLUSIONS
  Several basic blood count parameters after RHF can be concluded to significantly change, with some of those changes correlating with the clinical results (reduction of the DPED area).
authors.affiliation: IVth Department of Internal Medicine-Hematology, Faculty Hospital, Faculty of Medicine in Hradec Králové-Charles University in Prague, Sokolska Street 581, 500 05 Hradec Králové, Czech Republic.
authors.forename: Milan
authors.initials: M
authors.lastname: Košťál
authors.affiliation: IVth Department of Internal Medicine-Hematology, Faculty Hospital, Faculty of Medicine in Hradec Králové-Charles University in Prague, Sokolska Street 581, 500 05 Hradec Králové, Czech Republic.
authors.forename: Milan
authors.initials: M
authors.lastname: Bláha
authors.affiliation: Department of Ophthalmology, Faculty Hospital, Faculty of Medicine in Hradec Králové-Charles University in Prague, Sokolska Street 581, 500 05 Hradec Králové, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Rencová
authors.affiliation: IVth Department of Internal Medicine-Hematology, Faculty Hospital, Faculty of Medicine in Hradec Králové-Charles University in Prague, Sokolska Street 581, 500 05 Hradec Králové, Czech Republic.
authors.forename: Miriam
authors.initials: M
authors.lastname: Lánská
authors.affiliation: Department of Ophthalmology, Faculty Hospital, Faculty of Medicine in Hradec Králové-Charles University in Prague, Sokolska Street 581, 500 05 Hradec Králové, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Rozsíval
authors.affiliation: Department of Ophthalmology, Faculty Hospital, Faculty of Medicine in Hradec Králové-Charles University in Prague, Sokolska Street 581, 500 05 Hradec Králové, Czech Republic.
authors.forename: Vera
authors.initials: V
authors.lastname: Kratochvilová
authors.affiliation: Department of Ophthalmology, Faculty Hospital, Faculty of Medicine in Hradec Králové-Charles University in Prague, Sokolska Street 581, 500 05 Hradec Králové, Czech Republic.
authors.forename: Hana
authors.identifier: 0000-0001-8488-7208
authors.initials: H
authors.lastname: Langrová
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001772:Blood Cell Count; D001792:Blood Platelets / Q000166:cytology; D016238:Cytapheresis / Q000379:methods*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000166:cytology; D008268:Macular Degeneration / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D015593:Retinal Drusen / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome
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