title: Clinical efficacy of add-back therapy in treatment of endometriosis: a meta-analysis.
abstract: OBJECTIVE
  A meta-analysis was conducted to determine the effectiveness of using gonadotropin-releasing hormone analogues (GnRH-a), both with and without hormonal add-back therapy, for the management of endometriosis.
  
  
  METHODS
  Cochrane library, Ovid (Embase) and Pubmed databases were searched between the years 1998 and 2013 for published, prospective, randomised controlled trials (RCT) that assessed the effectiveness of "add-back" therapy for EMs treatment. The meta-analysis was performed using RevMan V5.0. The main outcome measures were as follows: lumbar spine bone mineral density (BMD) immediately after treatment and after 6 months of follow-up; femoral neck BMD; serum estradiol levels; changes in the Kupperman index score; the pelvic pain score, including dysmenorrhoea and dyspareunia; and pelvic tenderness.
  
  
  RESULTS
  A total of 13 RCT, including 945 participants, were identified. The evidence suggested that "add-back" therapy was more effective for symptom relief than GnRH-a alone. BMD was significantly different when comparing "add-back" therapy to GnRH-a alone, both immediately after treatment and at 6 months. The "add-back" therapy increased serum oestrogen and did not reduce the efficacy of GnRH-a for treating dysmenorrhoea and dyspareunia. A variety of add-back regimens had a same effect for the treatment of endometriosis.
  
  
  CONCLUSIONS
  "Add-back" therapy, based on the GnRH-a dose, does not reduce the efficacy of using GNRH-a for the management of endometriosis. "Add-back" therapy reduced the occurrence of side effects that can occur with GnRH-a therapy alone, such as osteoporosis and menopausal syndrome. There were no statistically significant differences when comparing the effectiveness of a variety of "add-back" regimens to each other.
authors.affiliation: Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, Hubei, China.
authors.forename: Debin
authors.initials: D
authors.lastname: Wu
authors.forename: Min
authors.initials: M
authors.lastname: Hu
authors.forename: Li
authors.initials: L
authors.lastname: Hong
authors.forename: Shasha
authors.initials: S
authors.lastname: Hong
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Ding
authors.forename: Jie
authors.initials: J
authors.lastname: Min
authors.forename: Gui
authors.initials: G
authors.lastname: Fang
authors.forename: Wenjun
authors.initials: W
authors.lastname: Guo
mesh_terms: D015519:Bone Density / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004412:Dysmenorrhea / Q000188:drug therapy; D004414:Dyspareunia / Q000188:drug therapy; D004715:Endometriosis / Q000188:drug therapy*; D004967:Estrogens / Q000097:blood; D005260:Female; D005272:Femur Neck / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D020249:Hormone Replacement Therapy; D006801:Humans; D008159:Lumbar Vertebrae / Q000502:physiology; D010147:Pain Measurement; D016032:Randomized Controlled Trials as Topic; D014591:Uterine Diseases / Q000188:drug therapy*
chemical_list: D004967:Estrogens; D007987:Gonadotropin-Releasing Hormone