title: Risk of central serous chorioretinopathy in adults prescribed oral corticosteroids: a population-based study in Taiwan.
abstract: OBJECTIVE
  To investigate the incidence and risk factors for central serous chorioretinopathy (CSCR) in adults who use oral corticosteroids in Taiwan.
  
  
  METHODS
  This is a population-based nested case-control study between 2000 and 2008. From the Taiwan National Health Insurance Research Database, adults who were repetitively prescribed oral corticosteroids were included as the study cohort. Of those, newly diagnosed CSCR cases were identified and the CSCR incidence was calculated. Subjects matched for age, gender, and the enrollment time were randomly selected as the controls. Corticosteroids use was compared between the cases and controls. Poisson and conditional logistic regressions were used to analyze the potential risk factors for CSCR.
  
  
  RESULTS
  Among 142,035 oral corticosteroids users, 320 cases of CSCR were identified, and 1,554 matched controls were randomly selected. The incidence rate of CSCR was 44.4 (95% confidence interval, 39.5-49.3) cases per 100,000 person-years. Multivariate Poisson regression showed that male patients and those aged 35 years to 44 years had significantly higher incidence rates of CSCR. There were no differences in either median dosage or mean duration of systemic corticosteroid treatment between the cases and controls. After adjusting for other confounders, current use of oral corticosteroids was found to be significantly associated with the risk of CSCR (odds ratio, 2.40; 95% confidence interval, 1.49-3.89).
  
  
  CONCLUSIONS
  Male gender, middle age, and current use of oral corticosteroids were found to be the risk factors for CSCR. However, oral corticosteroids dosage and treatment duration were not associated with the CSCR risk.
authors.affiliation: *Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan; †Department of Ophthalmology, National Yang-Ming University Hospital, Yilan, Taiwan; ‡Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; §Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan; ¶Cardiovascular Research Center, School of Medicine, National Yang-Ming University, Taipei, Taiwan; **Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; ††Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan; ‡‡Institute of Biomedical Sciences, Academia Sinica, Taichung, Taiwan; §§Healthcare and Management Center, Taipei Veterans General Hospital, Taipei, Taiwan; ¶¶Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; ***Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; and †††Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Der-Chong
authors.initials: DC
authors.lastname: Tsai
authors.forename: Shih-Jen
authors.initials: SJ
authors.lastname: Chen
authors.forename: Chin-Chou
authors.initials: CC
authors.lastname: Huang
authors.forename: Pesus
authors.initials: P
authors.lastname: Chou
authors.forename: Chia-Min
authors.initials: CM
authors.lastname: Chung
authors.forename: Wan-Leong
authors.initials: WL
authors.lastname: Chan
authors.forename: Po-Hsun
authors.initials: PH
authors.lastname: Huang
authors.forename: Shing-Jong
authors.initials: SJ
authors.lastname: Lin
authors.forename: Jaw-Wen
authors.initials: JW
authors.lastname: Chen
authors.forename: Tseng-Ji
authors.initials: TJ
authors.lastname: Chen
authors.forename: Hsin-Bang
authors.initials: HB
authors.lastname: Leu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D056833:Central Serous Chorioretinopathy / Q000139:chemically induced / Q000453:epidemiology*; D016208:Databases, Factual; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009313:National Health Programs / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan; D055815:Young Adult
chemical_list: D005938:Glucocorticoids