title: Radiosurgery with Helical Tomotherapy: Outcomes for Patients with One or Multifocal Brain Metastasis.
abstract: To evaluate the feasibility and report the preliminary results for stereotactic radiosurgery (SRS) treatments of single or multiple brain metastases delivered with helical tomotherapy (HT) by means of the InterFix™ Radiosurgery kit. Between September 2010 and August 2012, thirty patients underwent SRS for treatment of 46 brain metastases with a median prescription dose of 20 Gy (range 15-21 Gy). Clinical response was assessed with 2-3 month intervals by magnetic resonance imaging (MRI). Dose distribution indexes were computed and compared with published data for SRS performed with dedicated machines. After a median follow-up of 14 months (range 4-31) the estimated overall survival (OS) rate was 70% at 6 months, 60% at 12 months and 44% at 18 months. Local control (LC) was 72% at 6 months, 65% at 12 months and 50% at 18 months. Acute toxicity as headache and epileptic crisis occurred in only two patients. The mean values of conformity, homogeneity and gradient score indexes were 1.36, 1.04 and 50 respectively. HT-SRS for single or multiple brain metastases appears a reliable technique with encouraging clinical outcomes and competitive dosimetrical results.
authors.affiliation: Department of Radiation Oncology, IRCCS San Martino IST, National Cancer Research Institute, L.go R. Benzi 10, 16132 Genoa, Italy.
authors.forename: Salvina
authors.initials: S
authors.lastname: Barra
authors.affiliation: Department of Medical Physics, IRCCS San Martino IST, National Cancer Research Institute, L.go R. Benzi 10, 16132 Genoa, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Agostinelli
authors.affiliation: Department of Radiation Oncology, IRCCS San Martino IST, National Cancer Research Institute, L.go R. Benzi 10, 16132 Genoa, Italy stefano.vagge@unige.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Vagge
authors.affiliation: Department of Radiation Oncology, IRCCS San Martino IST, National Cancer Research Institute, L.go R. Benzi 10, 16132 Genoa, Italy.
authors.forename: Flavio
authors.initials: F
authors.lastname: Giannelli
authors.affiliation: Department of Neurosurgery, IRCCS San Martino IST, National Cancer Research Institute, L.go R. Benzi 10, 16132 Genoa, Italy.
authors.forename: Desiderio
authors.initials: D
authors.lastname: Siccardi
authors.affiliation: Department of Medical Physics, IRCCS San Martino IST, National Cancer Research Institute, L.go R. Benzi 10, 16132 Genoa, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Garelli
authors.affiliation: Department of Radiation Oncology, IRCCS San Martino IST, National Cancer Research Institute, L.go R. Benzi 10, 16132 Genoa, Italy.
authors.forename: Deborah
authors.initials: D
authors.lastname: Aloi
authors.affiliation: Department of Radiation Oncology, IRCCS San Martino IST, National Cancer Research Institute, L.go R. Benzi 10, 16132 Genoa, Italy.
authors.forename: Liliana
authors.initials: L
authors.lastname: Belgioia
authors.affiliation: Department of Radiation Oncology, IRCCS San Martino IST, National Cancer Research Institute, L.go R. Benzi 10, 16132 Genoa, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Bosetti
authors.affiliation: Department of Medical Physics, IRCCS San Martino IST, National Cancer Research Institute, L.go R. Benzi 10, 16132 Genoa, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Zeverino
authors.affiliation: Department of Radiation Oncology, IRCCS San Martino IST, National Cancer Research Institute, L.go R. Benzi 10, 16132 Genoa, Italy.
authors.forename: Renzo
authors.initials: R
authors.lastname: Corvò
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D016896:Treatment Outcome
keywords: Brain metastases; Helical Tomotherapy; InterFix; Radiosurgery; Stereotactic radiotherapy