title: Immunolocalization of antimicrobial and cytoskeletal components in the serous glands of human sinonasal mucosa.
abstract: Secretory cells in the seromucous glands of paranasal sinuses secrete antibacterial proteins for innate immune mucosal integrity. We studied the localization of antimicrobial and cytoskeletal components of the human seromucous glands and respiratory epithelium of the maxillary sinus and the ethmoidal cells by immunohistochemical methods. The presence of a variety of defense proteins such as lysozyme, lactoferrin, cathelicidin, and defensin-1, -2, -3 point to a crucial role in the immune defense for the respiratory tract. Cytoskeletal proteins such as actin, myosin 2, cytokeratin 7 and 19, α- and β-tubulin, investigated for the first time in glands of paranasal sinuses, showed a stronger expression at the apical and lateral cell membrane. The localization of the cytoskeletal proteins might point to their participation in exocrine secretory processes and stabilizing effects.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Technische Universität München, Munich, Germany. stoeckelhuber@mkg.med.tum.de.
authors.forename: Mechthild
authors.initials: M
authors.lastname: Stoeckelhuber
authors.affiliation: Department of Otorhinolaryngology, Ludwig Maximilians University of Munich Medical Center, Munich, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Olzowy
authors.affiliation: Department of Otorhinolaryngology, University of Göttingen, Göttingen, Germany.
authors.forename: Friedrich
authors.initials: F
authors.lastname: Ihler
authors.affiliation: Department of Otorhinolaryngology, University of Göttingen, Göttingen, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Matthias
authors.affiliation: Department of Otorhinolaryngology, Technische Universität München, Munich, Germany.
authors.forename: Elias Q
authors.initials: EQ
authors.lastname: Scherer
authors.affiliation: Institute of Pathology, Technische Universität München, Munich, Germany.
authors.forename: Gregor
authors.initials: G
authors.lastname: Babaryka
authors.affiliation: Department of Oral and Maxillofacial Surgery, Technische Universität München, Munich, Germany.
authors.forename: Denys J
authors.initials: DJ
authors.lastname: Loeffelbein
authors.affiliation: Department of Oral and Maxillofacial Surgery, Technische Universität München, Munich, Germany.
authors.forename: Nils H
authors.initials: NH
authors.lastname: Rohleder
authors.affiliation: Department of Oral and Maxillofacial Surgery, Technische Universität München, Munich, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Nieberler
authors.affiliation: Department of Oral and Maxillofacial Surgery, Technische Universität München, Munich, Germany.
authors.forename: Marco R
authors.initials: MR
authors.lastname: Kesting
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000737:chemistry*; D005088:Exocrine Glands / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000737:chemistry*; D010256:Paranasal Sinuses / Q000737:chemistry*; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D003598:Cytoskeletal Proteins