title: [Functional connectivity of temporal parietal junction in online game addicts:a resting-state functional magnetic resonance imaging study].
abstract: OBJECTIVE
  To explore the functions of temporal parietal junction (TPJ) as parts of attention networks in the pathogenesis of online game addiction using resting-state functional magnetic resonance imaging (fMRI).
  
  
  METHODS
  A total of 17 online game addicts (OGA) were recruited as OGA group and 17 healthy controls during the same period were recruited as CON group. The neuropsychological tests were performed for all of them to compare the inter-group differences in the results of Internet Addiction Test (IAT) and attention functions. All fMRI data were preprocessed after resting-state fMRI scanning. Then left and right TPJ were selected as regions of interest (ROIs) to calculate the linear correlation between TPJ and entire brain to compare the inter-group differences.
  
  
  RESULTS
  Obvious differences existed between OGA group (71 ± 5 scores) and CON group (19 ± 7 scores) in the IAT results and attention function (P < 0.05). Compared with the controls, right TPJ in online game addicts showed decreased functional connectivity with bilateral ventromedial prefrontal cortex (VMPFC), bilateral hippocampal gyrus and bilateral amygdaloid nucleus, but increased functional connectivity with right cuneus.However, left TPJ demonstrated decreased functional connectivity with bilateral superior frontal gyrus and bilateral middle frontal gyrus, but increased functional connectivity with bilateral cuneus (P < 0.05).
  
  
  CONCLUSIONS
  Altered functional connectivity of TPJ reflected its dysfunction in online game addicts.It suggests that TPJ is an important component of attention networks participating in the generation of online game addiction.
authors.affiliation: Department of Neurosurgery, Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Email: qianruobing@163.com.
authors.forename: Ruobing
authors.initials: R
authors.lastname: Qian
authors.forename: Bin
authors.initials: B
authors.lastname: Lin
authors.forename: Xianming
authors.initials: X
authors.lastname: Fu
authors.forename: Xiangpin
authors.initials: X
authors.lastname: Wei
authors.forename: Chuanbo
authors.initials: C
authors.lastname: Weng
authors.forename: Chaoshi
authors.initials: C
authors.lastname: Niu
authors.forename: Yehan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D016739:Behavior, Addictive / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D017397:Prefrontal Cortex / Q000503:physiopathology*; D055815:Young Adult