title: Longevity of Sm-p80-specific antibody responses following vaccination with Sm-p80 vaccine in mice and baboons and transplacental transfer of Sm-p80-specific antibodies in a baboon.
abstract: Based on data obtained using vaccine efficacy studies in mice, hamsters, and baboons, the credentials of Sm-p80 as a first tier vaccine candidate for schistosomiasis have been well established. Sm-p80-based vaccine formulation(s) have consistently exhibited potent prophylactic efficacy in reducing adult worm burden following cercarial challenge and induce killing of established adult worms in chronic infection. This vaccine is protective against both intestinal and urinary schistosomiasis. In this study, the longevity of Sm-p80-specific antibody responses was studied in mice and in baboons. Robust antibody titers were detected in mice for up to 60 weeks following vaccination with Sm-p80 recombinant vaccine (Sm-p80 + GLA-SE). In the follow-up experiments to our published studies, Sm-p80-specific IgG was also detected in baboons 5-8 years following the initial vaccination with an Sm-p80 DNA vaccine. In one baboon, transfer of Sm-p80-specific antibody was detected in umbilical cord blood and in the baby. These long-lasting humoral immune response data coupled with the vaccine efficacy data in rodents and nonhuman primates further strengthens the case for Sm-p80 to be moved forward through development leading to human clinical trials.
authors.affiliation: Center for Tropical Medicine and Infectious Diseases, Texas Tech University Health Sciences Center, 3601 4th Street, Mail Stop 6591, Lubbock, TX, 79430, USA.
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhang
authors.forename: Gul
authors.initials: G
authors.lastname: Ahmad
authors.forename: Loc
authors.initials: L
authors.lastname: Le
authors.forename: Juan U
authors.initials: JU
authors.lastname: Rojo
authors.forename: Souvik
authors.initials: S
authors.lastname: Karmakar
authors.forename: Kory A
authors.initials: KA
authors.lastname: Tillery
authors.forename: Workineh
authors.initials: W
authors.lastname: Torben
authors.forename: Raymond T
authors.initials: RT
authors.lastname: Damian
authors.forename: Roman F
authors.initials: RF
authors.lastname: Wolf
authors.forename: Gary L
authors.initials: GL
authors.lastname: White
authors.forename: David W
authors.initials: DW
authors.lastname: Carey
authors.forename: Darrick
authors.initials: D
authors.lastname: Carter
authors.forename: Steven G
authors.initials: SG
authors.lastname: Reed
authors.forename: Afzal A
authors.initials: AA
authors.lastname: Siddiqui
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000947:Antigens, Helminth / Q000276:immunology; D001700:Biomphalaria / Q000469:parasitology; D006224:Cricetinae; D005260:Female; D005312:Fetal Blood / Q000737:chemistry / Q000276:immunology; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood; D051379:Mice; D010215:Papio; D011247:Pregnancy; D012550:Schistosoma mansoni / Q000235:genetics / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000517:prevention & control*; D014611:Vaccination; D014612:Vaccines / Q000276:immunology*; D019444:Vaccines, DNA / Q000276:immunology
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007074:Immunoglobulin G; D014612:Vaccines; D019444:Vaccines, DNA
references.citation: Pediatr Allergy Immunol. 2009 Sep;20(6):528-35
references.pmid: 19220771
references.citation: Vaccine. 2014 Mar 5;32(11):1296-303
references.pmid: 24397898
references.citation: Vaccine. 2011 Apr 12;29(17):3341-55
references.pmid: 20713100
references.citation: PLoS One. 2013 Aug 05;8(8):e71185
references.pmid: 23940714
references.citation: Am J Trop Med Hyg. 2014 Jan;90(1):54-60
references.pmid: 24402703
references.citation: J Infect Dis. 2010 Apr 1;201(7):1105-12
references.pmid: 20187746
references.citation: Immunol Rev. 2010 Jul;236:139-50
references.pmid: 20636814
references.citation: Clin Vaccine Immunol. 2011 Feb;18(2):187-93
references.pmid: 21147936
references.citation: Parasitol Res. 2009 Nov;105(6):1767-77
references.pmid: 19809833
references.citation: Trends Parasitol. 2005 Mar;21(3):112-7
references.pmid: 15734657
references.citation: Acta Trop. 2013 Nov;128(2):423-40
references.pmid: 22580511
references.citation: Clin Vaccine Immunol. 2009 Jul;16(7):978-81
references.pmid: 19458206
references.citation: PLoS Negl Trop Dis. 2012;6(4):e1549
references.pmid: 22545163
references.citation: J Matern Fetal Neonatal Med. 2013 Jan;26(2):137-42
references.pmid: 23013166
references.citation: Vet Immunol Immunopathol. 2005 Apr 8;104(3-4):265-72
references.pmid: 15734547
references.citation: Vaccine. 2012 Nov 6;30(48):6753-8
references.pmid: 23000221
references.citation: PLoS Negl Trop Dis. 2013;7(3):e2106
references.pmid: 23505590
references.citation: Curr Opin HIV AIDS. 2010 Sep;5(5):409-13
references.pmid: 20978382
references.citation: Infect Immun. 2012 Apr;80(4):1583-92
references.pmid: 22252876
references.citation: Vaccine. 2005 Feb 10;23(12):1451-6
references.pmid: 15670880
references.citation: Acta Trop. 2002 May;82(2):183-92
references.pmid: 12020891
references.citation: J Infect Dis. 2010 Aug 15;202(3):470-9
references.pmid: 20575660
references.citation: Vaccine. 2012 Aug 10;30(37):5533-40
references.pmid: 22749797
references.citation: J Infect Dis. 2011 Nov;204(9):1437-49
references.pmid: 21921206
references.citation: Am J Trop Med Hyg. 2003 Jun;68(6):647-51
references.pmid: 12887021
references.citation: Parasite Immunol. 2002 Nov-Dec;24(11-12):521-5
references.pmid: 12694602
references.citation: Vaccine. 2011 Mar 9;29(12):2262-71
references.pmid: 21277404
references.citation: Transl Res. 2013 Sep;162(3):144-55
references.pmid: 23578479
references.citation: Scand J Immunol. 1992 Apr;35(4):429-37
references.pmid: 1557613
references.citation: Health Res Policy Syst. 2011 Jan 06;9:3
references.pmid: 21211001
references.citation: Clin Microbiol Rev. 2008 Jan;21(1):225-42
references.pmid: 18202444
references.citation: Vaccine. 2009 May 11;27(21):2830-7
references.pmid: 19366570
references.citation: Nat Med. 2013 Dec;19(12):1597-608
references.pmid: 24309663
references.citation: Expert Rev Vaccines. 2013 Jul;12(7):793-807
references.pmid: 23885824
references.citation: Urol Nurs. 2013 Jul-Aug;33(4):163-70
references.pmid: 24079113
references.citation: Acta Trop. 2010 Feb;113(2):95-104
references.pmid: 19962954
references.citation: Clin Vaccine Immunol. 2012 Jan;19(1):79-83
references.pmid: 22072721
references.citation: PLoS One. 2013 Jun 28;8(6):e67135
references.pmid: 23840604
references.citation: PLoS Negl Trop Dis. 2009 Aug 25;3(8):e412
references.pmid: 19707588
references.citation: J Infect Dis. 2014 Jun 15;209(12):1929-40
references.pmid: 24436452