title: The Glasgow Prognostic Score is an independent prognostic predictor of hepatocellular carcinoma following radical resection.
abstract: BACKGROUND
  Some prognostic evaluation systems were developed to postoperatively predict the outcome of hepatocellular carcinoma (HCC) patients, mainly based on the cancer itself and the underlying liver diseases. However, none of these prognostic evaluation systems have so far been universally accepted. A simple and feasible scoring system is still lacking for the prediction of prognosis of HCC patients following resection. We aimed to uncover the correlation between the preoperative Glasgow Prognostic Score (GPS) and the clinical outcome of HCC patients after radical resection.
  
  
  METHODS
  The patients were separated into 3 subgroups on the basis of their GPSs. The prognostic significance of the GPS in the patient cohort was evaluated by survival analysis.
  
  
  RESULTS
  On univariate analysis, the levels of C-reactive protein and albumin, the Child-Pugh class, vascular invasion, tumor number, tumor size, the tumor/node/metastasis (TNM) stage, and the GPS were associated with overall survival and time to recurrence of HCC patients after radical resection. On multivariate analysis, the tumor size, albumin level, and GPS were independently associated with the outcome of HCC postoperatively.
  
  
  CONCLUSIONS
  The GPS is an independent biomarker for prognostic prediction of HCC following radical resection.
authors.affiliation: Department of Oncosurgery, Affiliated Quanzhou First Hospital of Fujian Medical University, Quanzhou, Fujian, China.
authors.forename: Qun-Xiong
authors.initials: QX
authors.lastname: Pan
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Zhang
authors.forename: Zi-Jian
authors.initials: ZJ
authors.lastname: Su
authors.forename: Chong-Ren
authors.initials: CR
authors.lastname: Wang
authors.forename: Shao-Ying
authors.initials: SY
authors.lastname: Ke
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery*; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006498:Hepatectomy; D006801:Humans; D034141:Hypoalbuminemia / Q000097:blood / Q000401:mortality*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods*; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012709:Serum Albumin / Q000032:analysis; D013308:Streptonigrin; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D012709:Serum Albumin; C079133:retrostatin; D013308:Streptonigrin; D002097:C-Reactive Protein