title: Chemoselective intermolecular α-arylation of amides.
abstract: A new approach for the fully chemoselective α-arylation of amides is presented. By means of electrophilic amide activation, aryl groups can be regioselectively introduced α- to amides, even in the presence of esters and alkyl ketones. Mechanistic studies reveal key reaction intermediates and emphasize a remarkably subtle base effect in this transformation.
authors.affiliation: Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany).
authors.forename: Bo
authors.initials: B
authors.lastname: Peng
authors.forename: Danny
authors.initials: D
authors.lastname: Geerdink
authors.forename: Christophe
authors.initials: C
authors.lastname: Farès
authors.forename: Nuno
authors.initials: N
authors.lastname: Maulide
keywords: amides; arylation; chemoselectivity; keteniminium ions; sulfoxides