title: Tumor deposits in gastric carcinomas.
abstract: We performed this study to examine the prevalence of tumor deposits (TD) in gastric adenocarcinomas (GACa), and the relevance of their presence, size and type to clinical outcome. Ninety-six patients, histopathologically diagnosed as GACa following a total/subtotal gastrectomy were included, and clinicopathologic data were recorded. Due to the statistical analysis, the majority of TD(+) cases were of intestinal type and showed vascular invasion. In these cases, the incidence of local recurrence was significantly higher. The majority of GACa of intestinal type with TD were of high grade and showed vascular invasion. Recurrence and death were more commonly encountered among them. The recurrence-free survival (RFS) was significantly shorter in patients with TDs, which was also confirmed by multivariate analysis, and there was a significant difference between both RFS and overall survival of TD(+) and TD(-) cases of intestinal type GACa. In conclusion, in this study, we demonstrate that TDs are not infrequently observed in GACa, they are more commonly associated with the intestinal type and vascular invasive gastric cancers. Our study shows the prognostic impact of TDs, especially regarding the RFS. Therefore, the documentation of TDs might be considered for prospective studies, especially for the intestinal type GACa, a shortcoming of this study.
authors.affiliation: Dokuz Eylul University, Faculty of Medicine, Pathology Department, Turkey. Electronic address: aycaersen@gmail.com.
authors.forename: Ayca
authors.initials: A
authors.lastname: Ersen
authors.affiliation: Dokuz Eylul University, Faculty of Medicine, Pathology Department, Turkey.
authors.forename: Mehtat S
authors.initials: MS
authors.lastname: Unlu
authors.affiliation: Dokuz Eylul University, Faculty of Medicine, Department of Medical Oncology, Turkey.
authors.forename: Tulay
authors.initials: T
authors.lastname: Akman
authors.affiliation: Dokuz Eylul University, Faculty of Medicine, Pathology Department, Turkey.
authors.forename: Ozgul
authors.initials: O
authors.lastname: Sagol
authors.affiliation: Dokuz Eylul University, Faculty of Medicine, Department of Medical Oncology, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Oztop
authors.affiliation: Dokuz Eylul University, Faculty of Medicine, Department of General Surgery, Turkey.
authors.forename: Koray
authors.initials: K
authors.lastname: Atila
authors.affiliation: Dokuz Eylul University, Faculty of Medicine, Department of General Surgery, Turkey.
authors.forename: Seymen
authors.initials: S
authors.lastname: Bora
authors.affiliation: Dokuz Eylul University, Institute of Oncology, Turkey.
authors.forename: Huyla
authors.initials: H
authors.lastname: Ellidokuz
authors.affiliation: Dokuz Eylul University, Faculty of Medicine, Pathology Department, Turkey.
authors.forename: Sulen
authors.initials: S
authors.lastname: Sarioglu
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D009389:Neovascularization, Pathologic / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery
keywords: Gastric adenocarcinoma; Intestinal type; Tumor deposit; Vascular invasion