title: Skin Adverse Events During Dual and Triple Therapy for HCV-Related Cirrhosis.
abstract: BACKGROUND
  Dermatological adverse events are an existing concern during treatment of hepatitis C virus infection. Peginterferon/ribavirin treatment is associated with well-characterized dermatological lesions tending towards a uniform entity of dermatitis. New telaprevir- or boceprevir-based triple-therapy has led to significant improvements in sustained virological response rates, although associated with an increase in cutaneous adverse events compared peginterferon/ribavirin alone.
  
  
  METHODS
  We report a case of a patient who discontinued telaprevir because of severe skin eruptions and who, during ribavirin and interferon treatment, after a period free of skin lesions, developed new dermatological lesions different than those experienced during telaprevir treatment.
  
  
  CONCLUSIONS
  Several adverse effects are associated to anti-HCV drugs, hence appropriate skin care management and follow-up are very important. A careful anamnesis before the initiation of triple therapy is necessary to identify previous dermatological diseases that could increase skin adverse effects incidence.
authors.affiliation: Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Federico
authors.affiliation: Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, Naples, Italy.
authors.forename: Dolores
authors.initials: D
authors.lastname: Sgambato
authors.affiliation: Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, Naples, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Cotticelli
authors.affiliation: Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, Naples, Italy.
authors.forename: Antonietta Gerarda
authors.initials: AG
authors.lastname: Gravina
authors.affiliation: Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, Naples, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Dallio
authors.affiliation: Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, Naples, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Beneduce
authors.affiliation: Department of Dermatology, Second University of Naples, Naples, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Ruocco
authors.affiliation: Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, Naples, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Romano
authors.affiliation: Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, Naples, Italy.
authors.forename: Carmela
authors.initials: C
authors.lastname: Loguercio
keywords: Liver Cirrhosis; Skin Diseases; Telaprevir
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