title: Association study on ADAM33 polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.
abstract: BACKGROUND
  The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis.
  
  
  OBJECTIVE
  To assess whether the ADAM33 polymorphisms are associated with persistent allergic rhinitis (PER) due to house dust mites in a Chinese population.
  
  
  METHODS
  In a hospital-based case-control study of 515 patients with mite-sensitized PER and 495 healthy controls, we genotyped seven single nucleotide polymorphisms (SNPs) in ADAM33. Serum levels of eosinophil cationic protein, total IgE and allergen-specific IgE against Dermatophagoides pteronyssinus and Dermatophagoides farinae were measured by the ImmunoCAP assays.
  
  
  RESULTS
  In the single-locus analysis, three polymorphisms, rs3918392 (F1), rs528557 (S2) and rs2787093, were significantly associated with mite-sensitized PER. SNP S2 was associated with significantly increased risk both of asthmatic and nonasthmatic mite-sensitized PER. In the combined genotypes analysis, individuals with 2-4 risk alleles had a significantly higher risk of mite-sensitized PER (adjusted OR = 1.99, 95% CI = 1.50-2.62) than those with 0-1 risk alleles. Haplotype-based association analysis revealed that the ACAGCCT haplotype might have potential to protect against mite-sensitized PER (adjusted OR = 0.67; 95% CI = 0.49-0.90).
  
  
  CONCLUSIONS
  Polymorphisms in the ADAM33 gene may contribute to susceptibility of mite-sensitized PER in this Chinese population.
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Ruo-Xi
authors.initials: RX
authors.lastname: Chen
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Wen-Min
authors.initials: WM
authors.lastname: Lu
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Zhu
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Mei-Ping
authors.initials: MP
authors.lastname: Lu
authors.affiliation: Department of Molecular and Genetic Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China.
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Yun-Li
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Chen
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Xin-Jie
authors.initials: XJ
authors.lastname: Zhu
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China; International Centre for Allergy Research, Nanjing Medical University, Nanjing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yin
authors.affiliation: Department of Molecular and Genetic Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China.
authors.forename: Zheng-Dong
authors.initials: ZD
authors.lastname: Zhang
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China; International Centre for Allergy Research, Nanjing Medical University, Nanjing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cheng
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000150:complications; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007114:Immunization; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D065631:Rhinitis, Allergic / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000469:parasitology*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D051722:ADAM Proteins; C450441:ADAM33 protein, human
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