title: Regulation of immune reactivity by intercellular transfer.
abstract: It was recently proposed that T lymphocytes, which closely interact with APCs, can extract surface molecules from the presenting cells when they dissociate. These observations question the classical view of discrete interactions between phenotypically defined cell populations. In this review, we summarize some reports suggesting that membrane exchange at the immune synapse can be a vector for intercellular communication and envisage some consequences on the biology of T cells.
authors.affiliation: Laboratory of Immunobiology, Université Libre de Bruxelles , Gosselies , Belgium.
authors.forename: Maxime
authors.initials: M
authors.lastname: Dhainaut
authors.affiliation: Laboratory of Immunobiology, Université Libre de Bruxelles , Gosselies , Belgium.
authors.forename: Muriel
authors.initials: M
authors.lastname: Moser
keywords: T cell activation; T/APC interaction; costimulation; immune regulation; trogocytosis
references.citation: J Immunol. 1996 Aug 1;157(3):1062-70
references.pmid: 8757610
references.citation: Nat Immunol. 2013 Apr;14(4):356-63
references.pmid: 23475183
references.citation: J Immunol. 2011 Feb 15;186(4):2148-55
references.pmid: 21242518
references.citation: PLoS One. 2013;8(2):e56999
references.pmid: 23441229
references.citation: J Immunol. 2005 Jan 1;174(1):80-9
references.pmid: 15611230
references.citation: J Immunol. 2013 Jun 1;190(11):5856-65
references.pmid: 23626012
references.citation: J Exp Med. 2000 Apr 3;191(7):1137-48
references.pmid: 10748232
references.citation: Nat Immunol. 2002 Jan;3(1):27-32
references.pmid: 11731800
references.citation: Cell. 2009 May 29;137(5):974-4.e1
references.pmid: 19490900
references.citation: Nat Immunol. 2009 Aug;10(8):880-8
references.pmid: 19561613
references.citation: Science. 1967 Dec 22;158(3808):1573-5
references.pmid: 6060362
references.citation: J Exp Med. 2000 Oct 16;192(8):1105-13
references.pmid: 11034600
references.citation: J Immunol. 2001 Jul 15;167(2):875-83
references.pmid: 11441094
references.citation: Eur J Immunol. 2005 Aug;35(8):2284-94
references.pmid: 16021601
references.citation: J Immunol. 1999 Nov 15;163(10):5201-10
references.pmid: 10553040
references.citation: Nat Rev Immunol. 2007 Mar;7(3):238-43
references.pmid: 17290299
references.citation: Science. 1999 Oct 29;286(5441):952-4
references.pmid: 10542149
references.citation: J Immunol. 2001 Feb 15;166(4):2505-13
references.pmid: 11160311
references.citation: J Immunol. 2008 Aug 15;181(4):2271-5
references.pmid: 18684915
references.citation: J Immunol. 2002 Dec 1;169(11):6162-9
references.pmid: 12444120
references.citation: Blood. 2003 Apr 1;101(7):2704-10
references.pmid: 12433692
references.citation: Am J Transplant. 2005 Jul;5(7):1614-25
references.pmid: 15943619
references.citation: Immunity. 2011 Aug 26;35(2):208-22
references.pmid: 21820331
references.citation: J Immunol. 1981 Sep;127(3):888-92
references.pmid: 6167631
references.citation: Nat Rev Immunol. 2009 Aug;9(8):581-93
references.pmid: 19498381
references.citation: J Exp Med. 1973 Nov 1;138(5):1194-212
references.pmid: 4542806
references.citation: Cancer Res. 2008 Mar 15;68(6):2006-13
references.pmid: 18339883
references.citation: J Immunol. 2013 Sep 1;191(5):2282-9
references.pmid: 23913967
references.citation: J Immunol. 2008 Apr 15;180(8):5222-34
references.pmid: 18390703
references.citation: Cell Immunol. 2002 Jul-Aug;218(1-2):13-25
references.pmid: 12470610