title: An increase of interleukin-33 serum levels after coronary stent implantation is associated with coronary in-stent restenosis.
abstract: The study aim was to determine the predictive value of interleukin (IL)-33, a recently described member of the IL-1 family of cytokines, for the development of in-stent restenosis (ISR). IL-33 serum levels were measured in 387 consecutive patients undergoing percutaneous coronary intervention (PCI) of whom 193 had stable angina, 93 non-ST elevation myocardial infarction (NSTEMI), and 101 ST-elevation MI (STEMI), respectively. Blood was taken directly before and 24h after stent implantation. The presence of ISR was initially evaluated by clinical means after six to eight months. When presence of myocardial ischemia was suspected, coronary angiography was performed to confirm the suspected diagnosis of ISR. Clinical ISR was present in total in 34 patients (8.8%). IL-33 was detectable in 185 patients and was below detection limit in 202 patients. In patients with decreased IL-33 (n=95), unchanged or non-detectable levels (n=210) or increased levels of IL-33 after PCI (n=82), ISR-rate was 2.1%, 9.5% and 14.6%, respectively (p<0.05). Accordingly, patients with ISR showed a significant increase of IL-33 upon PCI (p<0.05). This association was independent from clinical presentation and risk factors as well as numbers and type of stents. In patients with both stable and unstable coronary artery disease, an increase of IL-33 serum levels after stent implantation is associated with a higher rate of in-stent restenosis.
authors.affiliation: Department of Internal Medicine II, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria. Electronic address: svitlana.demyanets@meduniwien.ac.at.
authors.forename: Svitlana
authors.initials: S
authors.lastname: Demyanets
authors.affiliation: 3rd Medical Department for Cardiology and Emergency Medicine, Wilhelminenhospital, Montleartstraße 37, 1160 Vienna, Austria.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Tentzeris
authors.affiliation: 3rd Medical Department for Cardiology and Emergency Medicine, Wilhelminenhospital, Montleartstraße 37, 1160 Vienna, Austria.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Jarai
authors.affiliation: Department of Internal Medicine II, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Währinger-Gürtel 18-20, 1090 Vienna, Austria.
authors.forename: Katharina M
authors.initials: KM
authors.lastname: Katsaros
authors.affiliation: 3rd Medical Department for Cardiology and Emergency Medicine, Wilhelminenhospital, Montleartstraße 37, 1160 Vienna, Austria.
authors.forename: Serdar
authors.initials: S
authors.lastname: Farhan
authors.affiliation: Department of Internal Medicine II, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria.
authors.forename: Anna
authors.initials: A
authors.lastname: Wonnerth
authors.affiliation: 3rd Medical Department for Cardiology and Emergency Medicine, Wilhelminenhospital, Montleartstraße 37, 1160 Vienna, Austria.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Weiss
authors.affiliation: Department of Internal Medicine II, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Währinger-Gürtel 18-20, 1090 Vienna, Austria.
authors.forename: Johann
authors.initials: J
authors.lastname: Wojta
authors.affiliation: Department of Internal Medicine II, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria.
authors.forename: Walter S
authors.initials: WS
authors.lastname: Speidl
authors.affiliation: 3rd Medical Department for Cardiology and Emergency Medicine, Wilhelminenhospital, Montleartstraße 37, 1160 Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Währinger-Gürtel 18-20, 1090 Vienna, Austria.
authors.forename: Kurt
authors.initials: K
authors.lastname: Huber
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000097:blood / Q000601:surgery; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis; D023903:Coronary Restenosis / Q000097:blood* / Q000175:diagnosis; D006331:Heart Diseases / Q000097:blood* / Q000601:surgery; D006801:Humans; D000067596:Interleukin-33; D007378:Interleukins / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood / Q000601:surgery; D062645:Percutaneous Coronary Intervention / Q000379:methods; D015607:Stents
chemical_list: C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins
keywords: Coronary artery disease; Interleukin-33; Myocardial infarction; Percutaneous coronary intervention; Restenosis
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