title: Update on medical management of Peyronie's disease.
abstract: The treatment of Peyronie's disease (PD) is a challenge for the clinician. In the quest to straighten the penis, alleviate pain, prevent further shortening, and restore erectile function, many non-surgical treatments have been offered in lieu of an operative approach, which is still considered the gold standard for definitive treatment. This communication is an update on the different approaches used in the minimally invasive management of this frustrating and yet intriguing condition.
authors.affiliation: Department of Urology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore, ronny_bw_tan@ttsh.com.sg.
authors.forename: Ronny B W
authors.initials: RB
authors.lastname: Tan
authors.forename: Premsant
authors.initials: P
authors.lastname: Sangkum
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Mitchell
authors.forename: Wayne J G
authors.initials: WJ
authors.lastname: Hellstrom
mesh_terms: D010129:4-Aminobenzoic Acid / Q000627:therapeutic use*; D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D019468:Disease Management; D019220:High-Energy Shock Waves / Q000627:therapeutic use*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D007478:Iontophoresis / Q000379:methods*; D008297:Male; D010411:Penile Induration / Q000628:therapy*; D010431:Pentoxifylline / Q000627:therapeutic use; D011878:Radiotherapy / Q000379:methods*; D011994:Recombinant Proteins / Q000627:therapeutic use; D033581:Stem Cell Transplantation / Q000379:methods*; D014143:Traction / Q000379:methods; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use*; D014700:Verapamil / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D014665:Vasodilator Agents; D014815:Vitamins; D014451:Ubiquinone; D014810:Vitamin E; D014700:Verapamil; C024989:coenzyme Q10; D010431:Pentoxifylline; D010129:4-Aminobenzoic Acid
references.citation: J Androl. 2009 Jul-Aug;30(4):397-405
references.pmid: 18974422
references.citation: J Sex Med. 2012 Feb;9(2):625-31
references.pmid: 22145832
references.citation: J Drug Target. 2009 Nov;17(9):690-700
references.pmid: 19845485
references.citation: J Urol. 1967 May;97(5):874-5
references.pmid: 6025934
references.citation: Expert Opin Pharmacother. 2011 Apr;12(6):931-44
references.pmid: 21405946
references.citation: Urology. 1994 Aug;44(2):291-5
references.pmid: 8048212
references.citation: J Sex Med. 2010 Apr;7(4 Pt 1):1391-400
references.pmid: 20141586
references.citation: Urology. 1998 Apr;51(4):620-6
references.pmid: 9586617
references.citation: Stem Cells Dev. 2012 Oct 10;21(15):2770-8
references.pmid: 22621212
references.citation: J Sex Med. 2009 Feb;6(2):558-66
references.pmid: 19138361
references.citation: N Engl J Med. 2009 Sep 3;361(10):968-79
references.pmid: 19726771
references.citation: J Sex Med. 2008 Jun;5(6):1468-73
references.pmid: 18373527
references.citation: Int J Impot Res. 2004 Jun;16(3):238-43
references.pmid: 14973528
references.citation: Nat Rev Urol. 2010 Apr;7(4):215-21
references.pmid: 20212516
references.citation: J Urol. 1993 Jan;149(1):56-8
references.pmid: 8417217
references.citation: J Urol. 2013 Jul;190(1):199-207
references.pmid: 23376148
references.citation: J Endourol. 1999 Oct;13(8):549-52
references.pmid: 10597123
references.citation: J Urol. 1999 Jun;161(6):1980-3
references.pmid: 10332485
references.citation: J Urol. 2000 Jun;163(6):1992-8
references.pmid: 10799245
references.citation: BJU Int. 2001 Jul;88(1):63-7
references.pmid: 11446848
references.citation: Asian J Androl. 2011 Mar;13(2):322-5
references.pmid: 21102473
references.citation: Int J Androl. 2012 Aug;35(4):521-7
references.pmid: 21950543
references.citation: J Urol. 1995 Feb;153(2):372-7
references.pmid: 7815587
references.citation: BJU Int. 2001 Jun;87(9):849-52
references.pmid: 11412225
references.citation: J Sex Med. 2010 Jun;7(6):2077-2085
references.pmid: 20367772
references.citation: J Sex Med. 2009 Mar;6(3):848-61
references.pmid: 19138374
references.citation: J Sex Med. 2010 Nov;7(11):3743-9
references.pmid: 20584114
references.citation: J Urol. 2006 Jul;176(1):394-8
references.pmid: 16753449
references.citation: J Sex Med. 2012 May;9(5):1435-41
references.pmid: 22781084
references.citation: J Urol. 2012 Jun;187(6):2268-74
references.pmid: 22503048
references.citation: BJU Int. 2003 Apr;91(6):522-4
references.pmid: 12656907
references.citation: J Sex Med. 2010 Jul;7(7):2359-74
references.pmid: 20497306
references.citation: Pathol Annu. 1988;23 Pt 1:297-330
references.pmid: 3387138
references.citation: BJU Int. 2010 Jul;106(2):240-8
references.pmid: 19863517
references.citation: J Urol. 2002 Aug;168(2):621-5; discussion 625-6
references.pmid: 12131321
references.citation: J Urol. 2004 Apr;171(4):1605-8
references.pmid: 15017231
references.citation: J Sex Med. 2004 Jul;1(1):6-23
references.pmid: 16422979
references.citation: Expert Rev Pharmacoecon Outcomes Res. 2004 Apr;4(2):235-42
references.pmid: 19807528
references.citation: Eur Urol. 2013 Mar;63(3):551-60
references.pmid: 23040209
references.citation: BJU Int. 2010 Nov;106(9):1352-6
references.pmid: 20438568
references.citation: BJU Int. 2002 Jun;89(9):895-900
references.pmid: 12010235
references.citation: Urology. 2006 May;67(5):1038-42
references.pmid: 16581113
references.citation: J Urol. 1975 Dec;114(6):898-900
references.pmid: 1195471
references.citation: J Sex Med. 2008 Aug;5(8):1985-90
references.pmid: 18554257
references.citation: J Urol. 1959 Jun;81(6):770-2
references.pmid: 13655401
references.citation: J Sex Med. 2008 Apr;5(4):954-964
references.pmid: 18042214
references.citation: Nitric Oxide. 2002 May;6(3):283-94
references.pmid: 12009846
references.citation: Int J Impot Res. 2010 Sep-Oct;22(5):298-309
references.pmid: 20720560
references.citation: J Androl. 1999 Jul-Aug;20(4):444-8
references.pmid: 10452584
references.citation: Int J Urol. 2006 Mar;13(3):244-7
references.pmid: 16643617
references.citation: Scand J Urol Nephrol. 1991;25(2):89-94
references.pmid: 1651559
references.citation: J Androl. 2012 Jan-Feb;33(1):3-14
references.pmid: 21350241
references.citation: J Urol. 1994 Jun;151(6):1522-4
references.pmid: 8189561
references.citation: J Sex Med. 2011 May;8(5):1472-7
references.pmid: 21324095
references.citation: J Urol. 1997 Oct;158(4):1388-90
references.pmid: 9302127
references.citation: Radiother Oncol. 1999 Jun;51(3):197-203
references.pmid: 10435813
references.citation: J Urol. 1999 Dec;162(6):2003-5
references.pmid: 10569556
references.citation: Int Urol Nephrol. 2009;41(3):467-71
references.pmid: 19199072
references.citation: Urol Clin North Am. 2011 May;38(2):195-205
references.pmid: 21621086
references.citation: J Bone Joint Surg Br. 1998 Jan;80(1):126-9
references.pmid: 9460968
references.citation: Actas Urol Esp. 2010 May;34(5):444-9
references.pmid: 20470717
references.citation: J Urol. 2007 Mar;177(3):972-5
references.pmid: 17296390
references.citation: Andrology. 2013 Jan;1(1):120-8
references.pmid: 23258640
references.citation: J Urol. 1997 Dec;158(6):2284-90
references.pmid: 9366377
references.citation: Drugs. 2007;67(4):527-45
references.pmid: 17352513
references.citation: Eur Urol. 2005 Apr;47(4):530-5; discussion 535-6
references.pmid: 15774254
references.citation: Eur J Dermatol. 2010 Mar-Apr;20(2):217-9
references.pmid: 20153994
references.citation: J Sex Med. 2011 Nov;8(11):3227-35
references.pmid: 21718447
references.citation: J Sex Med. 2009 Jun;6(6):1743-1754
references.pmid: 19453924
references.citation: BJU Int. 2001 May;87(7):654-7
references.pmid: 11350406
references.citation: J Urol. 2002 Dec;168(6):2483-5
references.pmid: 12441945
references.citation: J Urol. 2007 Oct;178(4 Pt 1):1398-403; discussion 1403
references.pmid: 17706714
references.citation: Inflamm Allergy Drug Targets. 2012 Feb;11(1):48-57
references.pmid: 22309083
references.citation: J Sex Med. 2007 Mar;4(2):477-84
references.pmid: 17367443
references.citation: J Sex Med. 2008 Jan;5(1):180-7
references.pmid: 18173766
references.citation: J Hand Surg Br. 1994 Aug;19(4):522-7
references.pmid: 7964107
references.citation: Trans West Sect Am Urol Assoc. 1953;20:32-5
references.pmid: 13179263
references.citation: J Urol. 1967 Jan;97(1):114-6
references.pmid: 6016195
references.citation: Nat Clin Pract Urol. 2005 Jun;2(6):291-7
references.pmid: 16474811
references.citation: South Med J. 1948 Feb;41(2):173-7
references.pmid: 18898262
references.citation: Eur Urol. 2009 Aug;56(2):363-9
references.pmid: 19473751
references.citation: Eur Urol. 2007 Mar;51(3):640-7
references.pmid: 17092631
references.citation: Br J Urol. 1996 Oct;78(4):613-22
references.pmid: 8944520
references.citation: J Sex Med. 2004 Jul;1(1):110-5
references.pmid: 16422991