title: Bone involvement and osteoporosis in mastocytosis.
abstract: Bone involvement is frequent in patients with systemic mastocytosis. Osteoporosis is the most prevalent bone manifestation, but diffuse osteosclerosis or focal osteolytic or osteosclerotic lesions are not infrequent. The risk of osteoporotic fractures is high, especially at the spine and in men. Routine measurements of bone mineral density and vertebral morphometry are warranted. The bone turnover markers indicate the involvement of complex bone metabolism in mastocytosis-related manifestations. Bisphosphonates represent the first-line treatment for osteoporosis-related mastocytosis.
authors.affiliation: University of Verona, Policlinico Borgo Roma, Piazzale Scuro, 10, Verona 37134, Italy. Electronic address: maurizio.rossini@univr.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Rossini
authors.affiliation: University of Verona, Policlinico Borgo Roma, Piazzale Scuro, 10, Verona 37134, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Zanotti
authors.affiliation: University of Verona, Policlinico Borgo Roma, Piazzale Scuro, 10, Verona 37134, Italy.
authors.forename: Ombretta
authors.initials: O
authors.lastname: Viapiana
authors.affiliation: University of Verona, Policlinico Borgo Roma, Piazzale Scuro, 10, Verona 37134, Italy.
authors.forename: Gaia
authors.initials: G
authors.lastname: Tripi
authors.affiliation: University of Verona, Policlinico Borgo Roma, Piazzale Scuro, 10, Verona 37134, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Orsolini
authors.affiliation: University of Verona, Policlinico Borgo Roma, Piazzale Scuro, 10, Verona 37134, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Idolazzi
authors.affiliation: University of Verona, Policlinico Borgo Roma, Piazzale Scuro, 10, Verona 37134, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Bonadonna
authors.affiliation: University of Verona, Policlinico Borgo Roma, Piazzale Scuro, 10, Verona 37134, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Schena
authors.affiliation: University of Verona, Policlinico Borgo Roma, Piazzale Scuro, 10, Verona 37134, Italy.
authors.forename: Luis
authors.initials: L
authors.lastname: Escribano
authors.affiliation: University of Verona, Policlinico Borgo Roma, Piazzale Scuro, 10, Verona 37134, Italy.
authors.forename: Silvano
authors.initials: S
authors.lastname: Adami
authors.affiliation: University of Verona, Policlinico Borgo Roma, Piazzale Scuro, 10, Verona 37134, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Gatti
mesh_terms: D000328:Adult; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D034721:Mastocytosis, Systemic / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D013131:Spine / Q000473:pathology*
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates
keywords: Bone mineral density; Bone turnover markers; Fracture; Mastocytosis; Osteoporosis; Osteosclerosis