title: Onabotulinum toxin A for the treatment of sialorrhea in familial dysautonomia.
abstract: Familial dysautonomia is a rare disease affecting the nervous system. Symptoms include speech and movement problems, anterior sialorrhea (drooling) due to hypersalivation as a consequence of poor oropharyngeal coordination; dysphagia and aspiration pneumonia secondary to recurrent posterior sialorrhea. The treatment for sialorrhea in this population is very challenging. Traditional drugs carry a number of side-effects that are difficult to control in this disease. We report the first documented case series of 3 patients with this condition that successfully responded to Onabotulinum toxin A injection into their salivary glands. This is an innovative, safe method for drooling control in this population.
authors.affiliation: Department of Otolaryngology Head & Neck Surgery, Montreal Children's Hospital, McGill University Health Center, Montreal, Quebec, Canada. Electronic address: sam.daniel@mcgill.ca.
authors.forename: Sam J
authors.initials: SJ
authors.lastname: Daniel
authors.affiliation: Department of Otolaryngology Head & Neck Surgery, Montreal Children's Hospital, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: Isabel
authors.initials: I
authors.lastname: Cardona
mesh_terms: D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D002648:Child; D003680:Deglutition Disorders / Q000175:diagnosis / Q000209:etiology; D004402:Dysautonomia, Familial / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D008297:Male; D011788:Quality of Life; D012469:Salivary Glands / Q000187:drug effects* / Q000378:metabolism; D012494:Sampling Studies; D012720:Severity of Illness Index; D012798:Sialorrhea / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D019274:Botulinum Toxins, Type A
keywords: Drooling; Familial dysautonomia; Onabotulinum toxin A; Riley day syndrome; Salivation; Sialorrhea