title: Hypolipidemic effect of the polysaccharides from Porphyra yezoensis.
abstract: This study was performed to investigate the hypolipidemic effect of the polysaccharides extracted from Porphyra yezoensis. Male Sprague-Dawley rats were divided into three groups and orally treated with diets containing either high fat, P. yezoensis polysaccharides (PPs), or normal fat. Treatment of male Sprague-Dawley rats with PPs led not only to significant decreases in plasma triacylglycerol, total cholesterol, and plasma low-density lipoprotein cholesterol and an increase in plasma high-density lipoprotein cholesterol, but also to significant decreases in liver weight, triacylglycerol and cholesterol. Therefore, the results suggest that PPs had a high hypolipidemic activity and could be used as a potential therapeutic agent for hyperlipidemia.
authors.affiliation: Department of Microbiology Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qian
authors.affiliation: Department of Microbiology Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China. Electronic address: zhoulygsh@sina.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Radiotherapy, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China. Electronic address: mjxlyg@sina.com.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Ma
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size; D011134:Polysaccharides / Q000494:pharmacology*; D044664:Porphyra / Q000737:chemistry*; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D000960:Hypolipidemic Agents; D011134:Polysaccharides; D014280:Triglycerides; D002784:Cholesterol
keywords: Hypolipidemic activity; Polysaccharides; Porphyra yezoensis