title: Organocatalyzed enantioselective Mannich reaction of pyrazoleamides with isatin-derived ketimines.
abstract: The first organocatalytic enantioselective Mannich reaction of pyrazoleamides with isatin-derived N-Boc ketimines has been developed to afford 2-oxindole-based chiral β-amino amides in good yields (84-97%) with excellent diastereo- and enantioselectivities (up to 99:1 dr and >99% ee).
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology , Shanghai 200237, PR China.
authors.forename: Tian-Ze
authors.initials: TZ
authors.lastname: Li
authors.forename: Xi-Bo
authors.initials: XB
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Sha
authors.forename: Xin-Yan
authors.initials: XY
authors.lastname: Wu