title: Towards XNA nanotechnology: new materials from synthetic genetic polymers.
abstract: Nucleic acids display remarkable properties beyond information storage and propagation. The well-understood base pairing rules have enabled nucleic acids to be assembled into nanostructures of ever increasing complexity. Although nanostructures can be constructed using other building blocks, including peptides and lipids, it is the capacity to evolve that sets nucleic acids apart from all other nanoscale building materials. Nonetheless, the poor chemical and biological stability of DNA and RNA constrain their applications. Recent advances in nucleic acid chemistry and polymerase engineering enable the synthesis, replication, and evolution of a range of synthetic genetic polymers (XNAs) with improved chemical and biological stability. We discuss the impact of this technology on the generation of XNA ligands, enzymes, and nanostructures with tailor-made chemistry.
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
authors.forename: Vitor B
authors.initials: VB
authors.lastname: Pinheiro
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK. Electronic address: ph1@mrc-lmb.cam.ac.uk.
authors.forename: Philipp
authors.initials: P
authors.lastname: Holliger
mesh_terms: D004798:Enzymes / Q000737:chemistry; D019143:Evolution, Molecular; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D004798:Enzymes; D009696:Nucleic Acids; D011108:Polymers
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