title: Maternal sleep duration and complaints of vital exhaustion during pregnancy is associated with placental abruption.
abstract: OBJECTIVE
  Sleep disorders are associated with cardiovascular complications and preterm delivery (PTD). Insufficient sleep results in metabolic alterations and increased inflammation, both known to contribute to placental abruption (abruption), a determinant of PTD. We examined associations of abruption with sleep duration and complaints of vital exhaustion.
  
  
  METHODS
  The study included 164 abruption cases and 160 controls in a multicenter study in Peru. Data on habitual sleep duration and vital exhaustion during the first 6 months of pregnancy were elicited during interviews conducted following delivery. Women were categorized according to short, normal and long sleep duration (≤6, 7-8 and ≥9 h); and frequency of feeling exhausted. Odds ratios (OR) and 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  Short and long sleep durations were associated with increased odds of abruption. The ORs of abruption in relation to short (≤6 h) and long (≥9 h) sleep duration were 2.0 (95% CI 1.1-3.7) and 2.1 (95% CI 1.1-4.1), compared with normal sleep duration (7-8 h). Complaints of vital exhaustion were also associated with abruption (OR = 2.37; 95% CI 1.46-3.85), and were independent of sleep duration.
  
  
  CONCLUSIONS
  We extend the existing literature and support the thesis that maternal sleep habits and disorders should be assessed among pregnant women.
authors.affiliation: Swedish Medical Center, Center for Perinatal Studies , Seattle, WA , USA .
authors.forename: Chunfang
authors.initials: C
authors.lastname: Qiu
authors.forename: Sixto E
authors.initials: SE
authors.lastname: Sanchez
authors.forename: Bizu
authors.initials: B
authors.lastname: Gelaye
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Enquobahrie
authors.forename: Cande V
authors.initials: CV
authors.lastname: Ananth
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Williams
mesh_terms: D000037:Abruptio Placentae / Q000503:physiopathology*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D012307:Risk Factors; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000503:physiopathology*; D013315:Stress, Psychological; D055815:Young Adult
keywords: Exhaustion; placental abruption; pregnancy; sleep duration
references.citation: Am J Epidemiol. 1991 Nov 1;134(9):965-72
references.pmid: 1951294
references.citation: J Obstet Gynaecol Res. 2009 Jun;35(3):446-52
references.pmid: 19527381
references.citation: Reprod Sci. 2007 Sep;14(6):560-7
references.pmid: 17959884
references.citation: Am J Hypertens. 1999 Jan;12(1 Pt 1):63-8
references.pmid: 10075386
references.citation: Am J Physiol. 1992 Sep;263(3 Pt 2):R708-15
references.pmid: 1357984
references.citation: Headache. 2005 Jul-Aug;45(7):904-10
references.pmid: 15985108
references.citation: Hypertension. 1996 Jun;27(6):1318-24
references.pmid: 8641742
references.citation: Biol Psychiatry. 1991 Mar 15;29(6):575-84
references.pmid: 1647222
references.citation: Am J Obstet Gynecol. 2010 Mar;202(3):261.e1-5
references.pmid: 20005507
references.citation: Am J Epidemiol. 2001 Feb 15;153(4):332-7
references.pmid: 11207150
references.citation: Am J Obstet Gynecol. 2007 Sep;197(3):273.e1-7
references.pmid: 17826417
references.citation: Chest. 2000 Jan;117(1):137-41
references.pmid: 10631211
references.citation: Sleep. 2005 Oct;28(10):1299-305
references.pmid: 16295215
references.citation: Sleep. 2010 Oct;33(10):1363-71
references.pmid: 21061859
references.citation: Am J Physiol. 1990 Sep;259(3 Pt 2):R439-46
references.pmid: 2396703
references.citation: Clin Exp Obstet Gynecol. 2009;36(3):166-8
references.pmid: 19860360
references.citation: Obstet Gynecol. 2004 Jul;104(1):71-7
references.pmid: 15229003
references.citation: J Clin Endocrinol Metab. 2004 Nov;89(11):5762-71
references.pmid: 15531540
references.citation: Epidemiology. 2011 Sep;22(5):738-44
references.pmid: 21734587
references.citation: Sleep. 2006 Aug;29(8):1009-14
references.pmid: 16944668
references.citation: Obstet Gynecol. 2010 Jan;115(1):77-83
references.pmid: 20027038
references.citation: Hypertension. 2000 May;35(5):1173-5
references.pmid: 10818083
references.citation: N Engl J Med. 2000 May 11;342(19):1378-84
references.pmid: 10805822
references.citation: Am J Obstet Gynecol. 2006 Jan;194(1):225-30
references.pmid: 16389036
references.citation: Paediatr Perinat Epidemiol. 2014 Mar;28(2):79-87
references.pmid: 24384058
references.citation: Matern Child Health J. 2013 May;17(4):723-31
references.pmid: 22782493
references.citation: Epidemiology. 2008 Nov;19(6):838-45
references.pmid: 18854708
references.citation: Sleep. 2004 Nov 1;27(7):1405-17
references.pmid: 15586794
references.citation: Sleep Med Rev. 2010 Apr;14(2):107-14
references.pmid: 19625199
references.citation: Best Pract Res Clin Haematol. 2003 Jun;16(2):135-51
references.pmid: 12763483