title: Comparative uptake of ¹⁸F-FEN-DPAZn2, ¹⁸F-FECH, ¹⁸F-fluoride, and ¹⁸F-FDG in fibrosarcoma and aseptic inflammation.
abstract: The aim of this study is to evaluate uptake of 2-(18)F-fluoroethyl-bis(zinc(II)-dipicolylamine) ((18)F-FEN-DPAZn2) as a promising cell death imaging agent, a choline analog (18)F-fluoroethylcholine ((18)F-FECH), (18)F-fluoride as a bone imaging agent, and a glucose analog 2-(18)F-fluoro-2-deoxy-d-glucose ((18)F-FDG) in the combined S180 fibrosarcoma and turpentine-induced inflammation mice models. The results showed that (18)F-FDG had the highest tumor-to-blood uptake ratio and tumor-to-muscle ratio, and high inflammation-to-blood ratio and inflammation-to-muscle ratio. (18)F -FECH showed moderate tumor-to-blood ratio and tumor-to-muscle ratio, and low inflammation-to-blood ratio and inflammation-to-muscle ratio. However, accumulation of (18)F FEN-DPAZn2 in tumor was similar to that in normal muscle. Also, (18)F-FEN-DPAZn2 and (18)F-fluoride exhibited the best selectivity to inflammation. (18)F-FECH positron emission tomography (PET) imaging demonstrates some advantages over (18)F-FDG PET for the differentiation of tumor from inflammation. (18)F FEN-DPAZn2 and (18)F-fluoride can be used for PET imaging of aseptic inflammation.
authors.affiliation: PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Liang
authors.affiliation: PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: gtang0224@126.com.
authors.forename: Ganghua
authors.initials: G
authors.lastname: Tang
authors.affiliation: PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Wang
authors.affiliation: PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Kongzhen
authors.initials: K
authors.lastname: Hu
authors.affiliation: Department of Applied Chemistry, South China Agricultural University, Guangzhou 510642, China. Electronic address: tangtxl1972@163.com.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Tang
authors.affiliation: PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Dahong
authors.initials: D
authors.lastname: Nie
authors.affiliation: PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Sun
authors.affiliation: PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Huang
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000378:metabolism*; D045744:Cell Line, Tumor; D002794:Choline / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D003937:Diagnosis, Differential; D005260:Female; D005354:Fibrosarcoma / Q000000981:diagnostic imaging / Q000378:metabolism*; D005459:Fluorides / Q000493:pharmacokinetics; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics*; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D007249:Inflammation / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D009928:Organ Specificity; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D010848:Picolinic Acids / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D014425:Turpentine
chemical_list: D005462:Fluorine Radioisotopes; D009942:Organometallic Compounds; D010848:Picolinic Acids; C529174:bis-dipicolylamine-Zinc(II); D019788:Fluorodeoxyglucose F18; C448902:fluoroethylcholine; D002794:Choline; D005459:Fluorides; D014425:Turpentine
keywords: (18)F-FDG; (18)F-FECH; (18)F-FEN-DPAZn2; (18)F-Fluoride; Inflammation; Tumor