title: [Advances of selenium supplementation in posttraumatic stress disorder risk group patients].
abstract: Posttraumatic stress disorder (PTSD) is a complex of symptoms developed in a patient after traumatic event. The basis of PTSD pathophysiology is hyper activation of neurones under stress factors influence, so-called excitotoxicity, followed by oxidative stress (OS) because of an accumulation of free radicals. Lipid peroxidation can lead to neurons damage. Neurons are especially susceptible to OS, changing signal transduction and information processing mechanisms. Clinically excitotoxicity preforms as different acute and/or chronic stress reactions and can cause PTSD. Selenium (Se) is involved on different stages of transport and metabolism of Glutamate. Research aim: to access PTSD incidence, OS parameters and their adjustment advances using organic Se in PTSD risk group patients. PTSD symptomatic severity (in PCL-M points) reduced for 5.85% to baseline, Prevalence Rate reduced for 46.03% to baseline in Se group patients. We can conclude that: 1) there is a statistically reliable correlations between the incidence of PTSD and OS parameters, between PTSD symptomatic severity and OS parameters; 2) the use of Se during the mission can reduce the OS parameters, minimize the incidence of PTSD and reduce the PTSD symptomatic severity.
authors.forename: V V
authors.initials: VV
authors.lastname: Voĭtsekhovskis
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Voĭtsekhovska
authors.forename: A
authors.initials: A
authors.lastname: Shkesters
authors.forename: G
authors.initials: G
authors.lastname: Antsane
authors.forename: A
authors.initials: A
authors.lastname: Silova
authors.forename: T
authors.initials: T
authors.lastname: Ivashchenko
authors.forename: Ia
authors.initials: Ia
authors.lastname: Michans
authors.forename: N
authors.initials: N
authors.lastname: Vaĭvads
mesh_terms: D000328:Adult; D019587:Dietary Supplements; D005609:Free Radicals / Q000037:antagonists & inhibitors / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007844:Latvia; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008889:Military Personnel; D018384:Oxidative Stress / Q000187:drug effects; D012307:Risk Factors; D012643:Selenium / Q000008:administration & dosage*; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology* / Q000523:psychology; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D005609:Free Radicals; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium