title: The expression of Bcl-2 and BID in gastric cancer cells.
abstract: BACKGROUND
  Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence of Helicobacter pylori infection, and patients' survival.
  
  
  METHODS
  The study involved 88 patients operated on for gastric cancer. The expressions of Bcl-2 and BID were determined immunohistochemically.
  
  
  RESULTS
  Positive Bcl-2 expression was found in 55.7% and, BID in 53.6% of patients. The Bcl-2 expression correlated with stage pT3 and T4 gastric cancer (P < 0.05), with the intestinal type according to Lauren (P < 0.001), ulcerated type according to Bormann's classification (P < 0.01), and with local lymph node metastases (P < 0.05).
  
  
  CONCLUSIONS
  The Bcl-2 protein plays a key role in the process of gastric cancer formation and is associated with the growth of definite types of gastric cancer.
authors.affiliation: Second Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Gryko
authors.affiliation: Department of General Pathomorphology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, Poland.
authors.forename: Anna
authors.identifier: 0000-0002-2786-7179
authors.initials: A
authors.lastname: Pryczynicz
authors.affiliation: Second Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, Poland.
authors.forename: Konrad
authors.identifier: 0000-0002-8093-5214
authors.initials: K
authors.lastname: Zareba
authors.affiliation: Second Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, Poland.
authors.forename: Bogusław
authors.initials: B
authors.lastname: Kędra
authors.affiliation: Department of General Pathomorphology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, Poland.
authors.forename: Andrzej
authors.identifier: 0000-0003-0893-2198
authors.initials: A
authors.lastname: Kemona
authors.affiliation: Department of General Pathomorphology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Guzińska-Ustymowicz
mesh_terms: D000368:Aged; D017209:Apoptosis; D051023:BH3 Interacting Domain Death Agonist Protein / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D016481:Helicobacter Infections / Q000235:genetics* / Q000382:microbiology / Q000401:mortality / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification / Q000472:pathogenicity; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis
chemical_list: D051023:BH3 Interacting Domain Death Agonist Protein; C494814:BID protein, human; D019253:Proto-Oncogene Proteins c-bcl-2
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