title: Multi-responsive and logic controlled release of DNA-gated mesoporous silica vehicles functionalized with intercalators for multiple delivery.
abstract: Novel DNA-gated mesoporous silica nanoparticle (MSN) vehicles functionalized with disulfide-linked acridinamine intercalators are constructed for multi-responsive controlled release. The DNA-gated MSN vehicles release cargo encapsulated in the MSN pores under different stimuli, including disulfide reducing agents, elevated temperature, and deoxyribonuclease I (DNase I), for codelivery of drugs and DNA/genes in different forms. Furthermore, the cascade release of encapsulated and intercalative drugs is controlled by AND logic gates in combination of dual stimuli. The ingeniously designed DNA-gated MSN vehicles integrates multiple responses and AND logic gate operations into a single smart nanodevice not only for codelivery of drugs and DNA/genes but also for cascade release of two drugs and has promising biological applications to meet diverse requirements of controlled release.
authors.forename: Shengwang
authors.initials: S
authors.lastname: Zhou
authors.forename: Xuezhong
authors.initials: X
authors.lastname: Du
authors.forename: Fangbo
authors.initials: F
authors.lastname: Cui
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D016503:Drug Delivery Systems; D004720:Endonucleases / Q000378:metabolism; D005452:Fluoresceins / Q000737:chemistry; D018014:Gene Transfer Techniques; D007364:Intercalating Agents / Q000737:chemistry*; D010084:Oxidation-Reduction; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013696:Temperature; D013997:Time Factors
chemical_list: D005452:Fluoresceins; D007364:Intercalating Agents; D012822:Silicon Dioxide; D004247:DNA; C427203:calf thymus DNA; D004720:Endonucleases; C007740:fluorexon