title: [Role of Sam68 in proliferation, invasion and migration of colorectal cancer cells in vitro].
abstract: OBJECTIVE
  To investigate the role of Sam68 (Src-associated substrate during mitosis 68 kD) in the occurrence and development of colorectal cancer.
  
  
  METHODS
  Colorectal cancer cell lines with stable Sam68 over-expressing and low Sam68 expression were established to test the effect of Sam68 in the proliferation, invasion, and migration of the cancer cells using colony formation, MTT and Transwell assays.
  
  
  RESULTS
  SW480 and Ls174t colorectal cell lines over-expressing Sam68 showed significantly enhanced cell proliferation, invasion and migration (P<0.05). Conversely, the low Sam68 expression in SW620 and HCT116 colorectal cell lines significantly suppressed the cell proliferation, invasion and migration (P<0.05).
  
  
  CONCLUSIONS
  The expression of Sam68 can promote the proliferation, invasion and migration of colorectal cancer cells lines in vitro.
authors.affiliation: Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail: 175252039@qq.com.
authors.forename: Liyang
authors.initials: L
authors.lastname: Wang
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Cui
authors.forename: Wenting
authors.initials: W
authors.lastname: Liao
authors.forename: Side
authors.initials: S
authors.lastname: Liu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D018797:Cell Cycle Proteins; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C489559:KHDRBS1 protein, human; D016601:RNA-Binding Proteins