title: High susceptibility to cytomegalovirus infection of pregnant women in Flanders, Belgium.
abstract: Maternal antibodies against cytomegalovirus (CMV) infection offer, to some extent, protection against congenital CMV infection. This study describes the seroprevalence of CMV-specific IgG in 220 parturient women during pregnancy, at delivery, at 3 months after delivery and in their cord blood (Flanders, Belgium, 2006-2008). ELISA was used to measure IgG. Of this population, 30% had positive IgG titres. Active transplacental transport was confirmed with a ratio 1.15/1. Elevated maternal IgG titre and increased parity, but not age, were significantly associated with higher seroprevalence of CMV-specific IgG in the cord blood. These data indicate a high susceptibility to CMV among fertile women. Prenatal prevention and other strategies to prevent intra-uterine infection are of critical importance in a highly susceptible population.
authors.affiliation: Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Universiteitsplein, 1a, 2610 Wilrijk, Antwerp, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Leuridan
authors.affiliation: Department of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, University of Antwerp.
authors.forename: M
authors.initials: M
authors.lastname: Ieven
authors.affiliation: Interuniversity Institute for Biostatistics and statistical Bioinformatics, Hasselt University, Campus Diepenbeek, Agoralaan 1, 3590 Diepenbeek & CHERMID, Vaccine and Infectious Disease Institute, Faculty of Medicine, University of Antwerp.
authors.forename: N
authors.initials: N
authors.lastname: Hens
authors.affiliation: Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Universiteitsplein, 1a, 2610 Wilrijk, Antwerp, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Van Damme
keywords: Cord blood; cytomegalovirus; maternal antibodies; pregnancy; seroprevalence; transplacental transport
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