title: Hypothyroxinemia induced by maternal mild iodine deficiency impairs hippocampal myelinated growth in lactational rats.
abstract: Hypothyroxinemia induced by maternal mild iodine deficiency causes neurological deficits and impairments of brain function in offspring. Hypothyroxinemia is prevalent in developing and developed countries alike. However, the mechanism underlying these deficits remains less well known. Given that the myelin plays an important role in learning and memory function, we hypothesize that hippocampal myelinated growth may be impaired in rat offspring exposed to hypothyroxinemia induced by maternal mild iodine deficiency. To test this hypothesis, the female Wistar rats were used and four experimental groups were prepared: (1) control; (2) maternal mild iodine deficiency diet inducing hypothyroxinemia; (3) hypothyroidism induced by maternal severe iodine deficiency diet; (4) hypothyroidism induced by maternal methimazole water. The rats were fed the diet from 3 months before pregnancy to the end of lactation. Our results showed that the physiological changes occuring in the hippocampal myelin were altered in the mild iodine deficiency group as indicated by the results of immunofluorescence of myelin basic proteins on postnatal day 14 and postnatal day 21. Moreover, hypothyroxinemia reduced the expressions of oligodendrocyte lineage transcription factor 2 and myelin-related proteins in the treatments on postnatal day 14 and postnatal day 21. Our data suggested that hypothyroxinemia induced by maternal mild iodine deficiency may impair myelinated growth of the offspring.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China.|Department of Endocrinology and Metabolism and Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China.|Department of Endocrinology and Metabolism and Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China.|Department of Endocrinology and Metabolism and Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Min
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Song
authors.affiliation: Department of Endocrinology and Metabolism and Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Shan
authors.affiliation: Department of Endocrinology and Metabolism and Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Teng
authors.affiliation: Department of Physiology, the University of Tennessee Health Science Center, Memphis, Tennessee, 38163, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xi
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China.|Department of Endocrinology and Metabolism and Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D005260:Female; D006624:Hippocampus / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000378:metabolism; D007454:Iodides / Q000378:metabolism; D007455:Iodine / Q000172:deficiency*; D007774:Lactation / Q000378:metabolism; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D009186:Myelin Sheath / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007454:Iodides; D007455:Iodine
keywords: hippocampus; hypothyroxinemia; iodine deficiency; myelinated growth