title: Changes in inflammatory, coagulopathic, and fibrinolytic responses after endovascular repair of an abdominal aortic aneurysm: relationship between fibrinogen degradation product levels and endoleaks.
abstract: OBJECTIVE
  To compare the inflammatory, coagulopathic, and fibrinolytic responses after endovascular aneurysm repair (EVAR) of an abdominal aortic aneurysm between two stent grafts. Fibrinogen degradation product (FDP) levels were compared between patients with or without an endoleak.
  
  
  METHODS
  EVAR was performed in 88 patients using an Excluder (37 patients) or a Zenith (51 patients). White blood cell count (WBC), C-reactive protein (CRP) levels, platelet count, and FDP levels were measured before and after EVAR.
  
  
  RESULTS
  WBC and CRP increased and the platelet count decreased significantly on days 1 and 3 after EVAR in the Zenith group compared with the Excluder group. The change in FDP from baseline to 7 days after EVAR was -1.99 ± 7.46 vs. 8.59 ± 9.38 μg/mL in patients with (n = 24) vs. without (n = 64) an endoleak (p < 0.001). A change in FDP of 3.1 μg/mL was the optimal cutoff point for predicting the presence of an endoleak (accuracy 0.762; sensitivity 0.875; specificity 0.717).
  
  
  CONCLUSIONS
  Inflammatory, coagulopathic, and fibrinolytic responses were greater in the Zenith group than in the Excluder group. A change in FDP of ≤3.1 μg/mL was predictive of an endoleak after EVAR.
authors.affiliation: Department of Radiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama-shi, Wakayama, 641-8510, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ikoma
authors.forename: Motoki
authors.initials: M
authors.lastname: Nakai
authors.forename: Morio
authors.initials: M
authors.lastname: Sato
authors.forename: Hirotatsu
authors.initials: H
authors.lastname: Sato
authors.forename: Hinako
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Tanaka
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sanda
authors.forename: Kouhei
authors.initials: K
authors.lastname: Nakata
authors.forename: Hiroki
authors.initials: H
authors.lastname: Minamiguchi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Sonomura
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Okamura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation / Q000502:physiology*; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D002097:C-Reactive Protein / Q000378:metabolism; D057867:Endoleak / Q000097:blood* / Q000175:diagnosis* / Q000000981:diagnostic imaging; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007958:Leukocyte Count / Q000379:methods; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods; D010976:Platelet Count / Q000379:methods; D011474:Prosthesis Design; D012189:Retrospective Studies; D036542:Tomography, Spiral Computed / Q000379:methods
chemical_list: D015415:Biomarkers; D005340:Fibrinogen; D002097:C-Reactive Protein
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