title: Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with ¹⁵O-H₂O PET.
abstract: OBJECTIVE
  This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against (15)O-H₂O positron-emission tomography (PET) and assesses the CFRs of coronary artery disease (CAD) patients.
  
  
  METHODS
  Thirty-two subjects underwent both dynamic CT perfusion (CTP) and PET perfusion imaging at rest and during pharmacological stress. In 12 normal subjects (pilot group), the calculation method for MBF and CFR was established. In the other 13 normal subjects (validation group), MBF and CFR obtained by dynamic CTP and PET were compared. Finally, the CFRs obtained by dynamic CTP and PET were compared between the validation group and CAD patients (n = 7).
  
  
  RESULTS
  Correlation between MBF of MDCT and PET was strong (r = 0.95, P < 0.0001). CFR showed good correlation between dynamic CTP and PET (r = 0.67, P = 0.0126). CFRCT in the CAD group (2.3 ± 0.8) was significantly lower than that in the validation group (5.2 ± 1.8) (P = 0.0011).
  
  
  CONCLUSIONS
  We established a method for measuring MBF and CFR with the relatively low-dose dynamic MDCT. Lower CFR was well demonstrated in CAD patients by dynamic CTP.
  
  
  CONCLUSIONS
  • MBF and CFR can be calculated using dynamic CTP with 320-row MDCT. • MBF and CFR showed good correlation between dynamic CTP and PET. • Lower CFR was well demonstrated in CAD patients by dynamic CTP.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Kita15, Nishi 7, kita-ku, Sapporo, 060-8638, Japan.
authors.forename: Yasuka
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Noriko
authors.initials: N
authors.lastname: Oyama-Manabe
authors.forename: Masanao
authors.initials: M
authors.lastname: Naya
authors.forename: Osamu
authors.initials: O
authors.lastname: Manabe
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Tomiyama
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
authors.forename: Chietsugu
authors.initials: C
authors.lastname: Katoh
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Kudo
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shirato
mesh_terms: D000328:Adult; D000368:Aged; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology*; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D010865:Pilot Projects; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D011829:Radiation Dosage; D012039:Regional Blood Flow / Q000502:physiology*; D015203:Reproducibility of Results
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