title: Geometrical guidance and trapping transition of human sperm cells.
abstract: The guidance of human sperm cells under confinement in quasi-2D microchambers is investigated using a purely physical method to control their distribution. Transport property measurements and simulations are performed with diluted sperm populations, for which effects of geometrical guidance and concentration are studied in detail. In particular, a trapping transition at convex angular wall features is identified and analyzed. We also show that highly efficient microratchets can be fabricated by using curved asymmetric obstacles to take advantage of the spermatozoa specific swimming strategy.
authors.affiliation: Instituto de Investigaciones Biológicas y Tecnológicas, CONICET and Centro de Biología Celular y Molecular, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000-Córdoba, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Guidobaldi
authors.affiliation: Institute for Nanoscale Physics and Chemistry, KU Leuven, B-3001 Leuven, Belgium.
authors.forename: Y
authors.initials: Y
authors.lastname: Jeyaram
authors.affiliation: Facultad de Matemática, Astronomía y Física, Universidad Nacional de Córdoba and IFEG-CONICET, X5000HUA Córdoba, Argentina.
authors.forename: I
authors.initials: I
authors.lastname: Berdakin
authors.affiliation: Institute for Nanoscale Physics and Chemistry, KU Leuven, B-3001 Leuven, Belgium.
authors.forename: V V
authors.initials: VV
authors.lastname: Moshchalkov
authors.affiliation: Facultad de Matemática, Astronomía y Física, Universidad Nacional de Córdoba and IFEG-CONICET, X5000HUA Córdoba, Argentina.
authors.forename: C A
authors.initials: CA
authors.lastname: Condat
authors.affiliation: Facultad de Matemática, Astronomía y Física, Universidad Nacional de Córdoba and IFEG-CONICET, X5000HUA Córdoba, Argentina.
authors.forename: V I
authors.initials: VI
authors.lastname: Marconi
authors.affiliation: Instituto de Investigaciones Biológicas y Tecnológicas, CONICET and Centro de Biología Celular y Molecular, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000-Córdoba, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: Giojalas
authors.affiliation: Département de Physique, Université de Liège, B-4000 Sart Tilman, Belgium.
authors.forename: A V
authors.initials: AV
authors.lastname: Silhanek
mesh_terms: D002449:Cell Aggregation / Q000502:physiology*; D002469:Cell Separation / Q000379:methods*; D002478:Cells, Cultured; D003198:Computer Simulation; D006801:Humans; D008297:Male; D008954:Models, Biological; D013081:Sperm Motility / Q000502:physiology*; D013094:Spermatozoa / Q000166:cytology* / Q000502:physiology*