title: Volumetric analysis of amygdala, hippocampus, and prefrontal cortex in therapy-naive PTSD participants.
abstract: OBJECTIVE
  In our study we have hypothesized that volume changes of amygdala, hippocampus, and prefrontal cortex are more pronounced in male posttraumatic stress disorder participants.
  
  
  METHODS
  We have conducted a study of 79 male participants who underwent MRI brain scanning. PTSD diagnosis was confirmed in 49 participants. After MRI was taken all scans were software based volume computed and statistically processed.
  
  
  RESULTS
  We found that left amygdala is the most significant parameter for distinction between PTSD participants and participants without PTSD. There were no significant differences in volumes of hippocampi and prefrontal cortices. Roc curve method outlined left amygdala AUC = 0.898 (95% CI = 0.830-0.967) and right amygdala AUC = 0.882 (95% CI = 0.810-0.954) in the group of PTSD participants which makes both variables highly statistically significant.
  
  
  CONCLUSIONS
  The present investigation revealed significant volume decrease of left amygdala in PTSD patients. Concerning important functions of the amygdala and her neuroanatomical connections with other brain structures, we need to increase number of participants to clarify the correlation between impared amygdala and possible other different brain structures in participants with PTSD.
authors.affiliation: Institute of Anatomy "NikoMiljanić", Medical Faculty, Dr Subotića 4, University of Belgrade, Belgrade, Serbia.
authors.forename: Ana
authors.identifier: 0000-0003-2117-4213
authors.initials: A
authors.lastname: Starcevic
authors.affiliation: Clinic of Dental Prosthetic, The Faculty of Stomatology, University of Belgrade, Serbia.
authors.forename: Srdjan
authors.identifier: 0000-0001-9640-3282
authors.initials: S
authors.lastname: Postic
authors.affiliation: Institute for Statistics, Faculty of Organizational Sciences, University of Belgrade, Serbia.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Radojicic
authors.affiliation: Institute for Traumatology, Emergency Center, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Serbia.
authors.forename: Branislav
authors.identifier: 0000-0001-9403-134X
authors.initials: B
authors.lastname: Starcevic
authors.affiliation: Institute for Psychiatry, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Serbia.
authors.forename: Srdjan
authors.initials: S
authors.lastname: Milovanovic
authors.affiliation: Institute for Psychiatry, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Serbia.
authors.forename: Andrej
authors.initials: A
authors.lastname: Ilankovic
authors.affiliation: Institute for Psychiatry, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Serbia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Dimitrijevic
authors.affiliation: Institute for Psychiatry, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Serbia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Damjanovic
authors.affiliation: Institute of Anatomy "NikoMiljanić", Medical Faculty, Dr Subotića 4, University of Belgrade, Belgrade, Serbia.
authors.forename: Milan
authors.initials: M
authors.lastname: Aksić
authors.affiliation: Institute of Anatomy "NikoMiljanić", Medical Faculty, Dr Subotića 4, University of Belgrade, Belgrade, Serbia.
authors.forename: Vidosava
authors.initials: V
authors.lastname: Radonjic
mesh_terms: D000328:Adult; D000679:Amygdala / Q000000981:diagnostic imaging*; D006624:Hippocampus / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging*; D011859:Radiography; D013313:Stress Disorders, Post-Traumatic / Q000000981:diagnostic imaging*
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