title: [Comparative analysis of the influence of nano- and ionic forms of silver on biochemical indices in laboratory animals].
abstract: A comparative analysis of the effect of silver nanoparticles (SNP) with a diameter of 14 nm and silver sulfate (SS) on biochemical indices of the state of the organism under the administration of preparations with drinking water to mice F1 CBAxC57Bl (from 0.1 to 500 mg Ag/l for 2 weeks) and nonlinear rats (from 0.01 to 5 mg Ag/l within 6 months) has been performed In the experiment on mice there was found an increase in activity of glutathione reductase (GR) in erythrocytes under the administration of both drugs and reduction of antiradical activity of serum--under the introduction of SNP only. The administration of low doses of SNP in the experiment on rats caused much less pronounced changes in serum markers of the state of the liver; kidneys, protein and lipids metabolism in comparison with equivalent doses of the SS, that as a whole with the qualitative differences on GR activity in erythrocytes satisfactorily was explained by activation of phagocytic cells with nanoparticles. Thus, for the first time the SNP biological effects in animals were shown to be caused both by the exposure to solubilized Ag+ ions and by the response of cells to the surface of the nanoparticles themselves.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Rakhmanin
authors.forename: L V
authors.initials: LV
authors.lastname: Khripach
authors.forename: R I
authors.initials: RI
authors.lastname: Mikhaylova
authors.forename: Z I
authors.initials: ZI
authors.lastname: Koganova
authors.forename: T D
authors.initials: TD
authors.lastname: Knyazeva
authors.forename: E V
authors.initials: EV
authors.lastname: Zheleznyak
authors.forename: O N
authors.initials: ON
authors.lastname: Savostikova
authors.forename: A V
authors.initials: AV
authors.lastname: Alekseeva
authors.forename: I V
authors.initials: IV
authors.lastname: Voinova
authors.forename: E V
authors.initials: EV
authors.lastname: Kruglova
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D053768:Metal Nanoparticles; D051379:Mice; D008810:Mice, Inbred C57BL; D010316:Particle Size; D051381:Rats; D012834:Silver / Q000737:chemistry*
chemical_list: D012834:Silver; D005980:Glutathione Reductase