title: microRNAs as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome.
abstract: Obesity is associated closely with the metabolic syndrome (MS). It is well known that obesity-induced chronic inflammation plays a fundamental role in the pathogenesis of MS. White adipose tissue (AT) is the primary site for the initiation and exacerbation of obesity-associated inflammation. Exploring the mechanisms of white AT inflammation and resetting the immunological balance in white AT could be crucial for the management of MS. Several prominent molecular mechanisms have been proposed to mediate inflammation in white AT, including hypoxia, endoplasmic reticulum stress, lipotoxicity, and metabolic endotoxemia. Recently, a growing body of evidence supports the role of miRNAs as a new important inflammatory mediator by regulating both the adaptive and innate immunity. This review will focus on the implication of miRNAs in white AT inflammation in obesity, and will also highlight the potential of miRNAs as targets for therapeutic intervention in MS as well as the challenges lying in miRNA-targeting therapeutics.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Ge
authors.affiliation: Endocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research, Medical Sector, University of Louvain, 1200 Brussels, Belgium.
authors.forename: Sonia
authors.initials: S
authors.lastname: Brichard
authors.affiliation: Neurology Unit, Daping Hospital, Research Institute of Surgery, The Third Military Medical University, Chongqing 400042, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yi
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: QiFu
authors.initials: Q
authors.lastname: Li
mesh_terms: D056704:Adaptive Immunity; D052436:Adipose Tissue, White / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D059865:Endoplasmic Reticulum Stress / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D006801:Humans; D000860:Hypoxia / Q000235:genetics / Q000276:immunology; D007113:Immunity, Innate; D007249:Inflammation / Q000150:complications / Q000235:genetics / Q000276:immunology / Q000628:therapy; D024821:Metabolic Syndrome / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics* / Q000276:immunology; D058990:Molecular Targeted Therapy; D009765:Obesity / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000628:therapy
chemical_list: D035683:MicroRNAs
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