title: CD30 in systemic mastocytosis.
abstract: CD30 is a transmembrane receptor, normally not expressed by mast cells, which regulates proliferation/apoptosis and antibody responses. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. This article highlights the expression profile and role of CD30 and CD30L in physiologic and pathologic conditions, the applicability of CD30 as a marker for systemic mastocytosis, the consequences of mast cell-expressed CD30, and the possibility of future anti-CD30 based cytoreductive therapies.
authors.affiliation: Department of Allergology, Groningen Research Institute of Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Bjorn
authors.initials: B
authors.lastname: van Anrooij
authors.affiliation: Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Philip M
authors.initials: PM
authors.lastname: Kluin
authors.affiliation: Department of Allergology, Groningen Research Institute of Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Joanne N G
authors.initials: JN
authors.lastname: Oude Elberink
authors.affiliation: Department of Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands. Electronic address: j.c.kluin@umcg.nl.
authors.forename: Johanna C
authors.initials: JC
authors.lastname: Kluin-Nelemans
mesh_terms: D000328:Adult; D000906:Antibodies / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D053285:CD30 Ligand / Q000097:blood / Q000235:genetics / Q000276:immunology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017730:Ki-1 Antigen / Q000037:antagonists & inhibitors / Q000097:blood / Q000235:genetics* / Q000276:immunology; D008213:Lymphocyte Activation; D008407:Mast Cells / Q000276:immunology / Q000473:pathology*; D034721:Mastocytosis, Systemic / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D011379:Prognosis; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*
chemical_list: D000906:Antibodies; D053285:CD30 Ligand; D017730:Ki-1 Antigen; C505774:TNFSF8 protein, human
keywords: CD153; CD30; CD30 ligand; Soluble CD30; Systemic mastocytosis