title: [Association between the single nucleotide polymorphisms of human CD36 gene and acute coronary syndrome].
abstract: OBJECTIVE
  The aim of the present study was to assess the association between the polymorphisms of CD36 gene and acute coronary syndrome(ACS).
  
  
  METHODS
  Genotypes of CD36 single nucleotide polymorphisms were detected under PCR-RFLP in 522 patients with ACS and 1 215 controls.
  
  
  RESULTS
  For people under Han and Uygur ethnicities, the distribution of genotypes and allele of rs1722505 was significantly different between ACS and the controls(all P < 0.05). For Han population, the frequency of A allele of rs17154181 was significantly lower in ACS group than that in the control group(P = 0.034). Results from logistic regression analysis showed that the AA+AG genotype of rs1722505 was significantly higher in ACS patients than that in controls both between the Hans and the Uygurs(OR = 1.436, 95%CI:1.047-1.970, P = 0.025;OR = 1.589, 95%CI:1.009-2.473, P = 0.046, respectively). For Han people,AA+AG genotype of rs17154181 was significantly lower in ACS patients than that in controls(OR = 0.667, 95% CI:0.494-0.900, P = 0.008).
  
  
  CONCLUSIONS
  Data from the present study suggested that the CD36 gene might serve as a genetic marker of ACS in both Han and Uygur populations.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Junyi
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. Email: myt-xj@163.com.
authors.forename: Yitong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Yining
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Zixiang
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: He
authors.affiliation: Key Laboratory of Cardiovascular Disease Research, Urumqi.
authors.forename: Bangdang
authors.initials: B
authors.lastname: Chen
authors.affiliation: Key Laboratory of Cardiovascular Disease Research, Urumqi.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
mesh_terms: D054058:Acute Coronary Syndrome / Q000453:epidemiology / Q000235:genetics*; D000483:Alleles; D018955:CD36 Antigens / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: D018955:CD36 Antigens