title: Bdnf DNA methylation modifications in the hippocampus and amygdala of male and female rats exposed to different caregiving environments outside the homecage.
abstract: We have previously shown in infant rats that brief and repeated experiences with a stressed dam outside the homecage (maltreatment) alters methylation of DNA associated with the brain-derived neurotrophic factor (bdnf) gene within the developing and adult prefrontal cortex. BDNF is a key mediator of activity-dependent processes that have a profound influence on neural development and plasticity. Here we examined whether maltreatment also alters bdnf DNA methylation in two additional regions known to be prominently affected by diverse forms of early life adversity in humans- the hippocampus and amygdala. We found significant bdnf DNA methylation modifications present within the adult hippocampus (dorsal and ventral) and amygdala (central/basolateral complex). We observed that the nature of change differed between sexes, gene locus (bdnf I vs. IV), and brain region. Furthermore, a manipulation that did not produce any obvious behavior difference in infants (brief and repeated experiences with a nurturing foster dam) also had long-term effects on methylation. These data provide further empirical support of DNA methylation modifications as biological consequences of caregiving environments.
authors.affiliation: Department of Psychology, University of Delaware, 108 Wolf Hall, Newark, DE, 19716. troth@psych.udel.edu.
authors.forename: Tania L
authors.initials: TL
authors.lastname: Roth
authors.forename: Stephanie
authors.initials: S
authors.lastname: Matt
authors.forename: Kenneth
authors.initials: K
authors.lastname: Chen
authors.forename: Jennifer
authors.initials: J
authors.lastname: Blaze
mesh_terms: D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D019175:DNA Methylation / Q000502:physiology*; D004777:Environment; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D051381:Rats
chemical_list: D019208:Brain-Derived Neurotrophic Factor
keywords: DNA methylation; amygdala; bdnf; epigenetic; foster care; hippocampus; maltreatment
references.citation: Horm Behav. 2006 Nov;50(4):623-31
references.pmid: 16914153
references.citation: Pediatr Neurol. 1996 Sep;15(2):114-9
references.pmid: 8888044
references.citation: Arch Gen Psychiatry. 2010 Mar;67(3):258-67
references.pmid: 20194826
references.citation: Int J Epidemiol. 2012 Feb;41(1):62-74
references.pmid: 22422449
references.citation: PLoS One. 2011;6(8):e23881
references.pmid: 21912609
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2011 Sep;156B(6):700-8
references.pmid: 21714072
references.citation: Nucleic Acids Res. 2010 Jun;38(11):e125
references.pmid: 20371518
references.citation: Trends Neurosci. 2013 Jan;36(1):3-13
references.pmid: 23041052
references.citation: Ann N Y Acad Sci. 2010 Jun;1199:186-93
references.pmid: 20633124
references.citation: PLoS One. 2010 Jan 26;5(1):e8888
references.pmid: 20126651
references.citation: Nat Neurosci. 2009 Mar;12(3):342-8
references.pmid: 19234457
references.citation: Neuron. 2011 Jan 27;69(2):359-72
references.pmid: 21262472
references.citation: Science. 2008 May 30;320(5880):1224-9
references.pmid: 18511691
references.citation: Biol Psychiatry. 2009 May 1;65(9):760-9
references.pmid: 19150054
references.citation: Transl Psychiatry. 2013 Jan 15;3:e207
references.pmid: 23422958
references.citation: Dev Neurosci. 2012;34(2-3):101-14
references.pmid: 22571921
references.citation: Front Psychiatry. 2011 May 03;2:21
references.pmid: 21629839
references.citation: Dev Psychobiol. 2012 Sep;54(6):590-7
references.pmid: 22714649
references.citation: Nat Neurosci. 2009 Dec;12(12):1559-66
references.pmid: 19898468
references.citation: Dev Neurosci. 2013;35(4):306-16
references.pmid: 23751776
references.citation: Arch Gen Psychiatry. 2012 Jul;69(7):722-31
references.pmid: 22752237
references.citation: Parent Sci Pract. 2012 Apr 1;12(2-3):202-211
references.pmid: 23162380
references.citation: Front Psychiatry. 2013 Aug 01;4:78
references.pmid: 23914177
references.citation: Endocrinology. 2010 Oct;151(10):4871-81
references.pmid: 20702577
references.citation: Neurosci Lett. 2008 Jul 25;440(1):49-53
references.pmid: 18539393
references.citation: Science. 2013 Aug 9;341(6146):1237905
references.pmid: 23828890
references.citation: PLoS Genet. 2013 Apr;9(4):e1003433
references.pmid: 23593028
references.citation: Biol Psychiatry. 2012 Jul 1;72(1):41-8
references.pmid: 22444201
references.citation: J Comp Physiol Psychol. 1979 Aug;93(4):677-84
references.pmid: 479402
references.citation: Curr Protoc Neurosci. 2012 Jul;Chapter 7:Unit 7.24
references.pmid: 22752896
references.citation: Dev Psychobiol. 2012 Sep;54(6):578-89
references.pmid: 21432850
references.citation: Neuropharmacology. 2013 Dec;75:106-15
references.pmid: 23916482
references.citation: Neuropsychopharmacology. 2012 Jun;37(7):1647-55
references.pmid: 22353757
references.citation: Biol Psychiatry. 2010 Jun 15;67(12):1137-45
references.pmid: 20163787
references.citation: Neuroscience. 2008 Jun 26;154(3):1132-42
references.pmid: 18501521
references.citation: Child Dev. 2013 Jan-Feb;84(1):49-57
references.pmid: 22880724
references.citation: J Psychiatr Res. 2011 Jul;45(7):919-26
references.pmid: 21306736
references.citation: PLoS One. 2008 May 07;3(5):e2085
references.pmid: 18461137
references.citation: J Neurosci. 2009 Oct 14;29(41):12764-7
references.pmid: 19828787
references.citation: J Neurosci. 2008 Sep 3;28(36):9055-65
references.pmid: 18768700
references.citation: Br J Pharmacol. 2011 Nov;164(6):1711-21
references.pmid: 21585346
references.citation: J Neurosci. 2008 Oct 15;28(42):10576-86
references.pmid: 18923034
references.citation: Nat Rev Neurosci. 2013 Jan;14(1):7-23
references.pmid: 23254191
references.citation: Biol Psychiatry. 2005 Apr 15;57(8):823-31
references.pmid: 15820702
references.citation: Environ Mol Mutagen. 2008 Jan;49(1):46-60
references.pmid: 18095330
references.citation: Transl Psychiatry. 2012 Aug 14;2:e150
references.pmid: 22892716
references.citation: Annu Rev Psychol. 2007;58:145-73
references.pmid: 16903808
references.citation: Dev Psychobiol. 2014 Apr;56(3):392-406
references.pmid: 23460384
references.citation: Front Behav Neurosci. 2009 Sep 24;3:27
references.pmid: 19826614
references.citation: Proc Natl Acad Sci U S A. 2013 May 14;110(20):8302-7
references.pmid: 23630272