title: Effect of BRMS1 on tumorigenicity and metastasis of human rectal cancer.
abstract: Breast cancer metastasis suppressor gene-1 (BRMS1) is newly discovered tumor metastasis gene, which has been reported to play an important role in the progression of human tumor. However, its role in rectal cancer has never been investigated. In this present study, we evaluated the associated of BRMS1 with colorectal cancer, its value in prognosis, and its role in metastasis of rectal cancer. BRMS1 expression examined in 80 patients and the role of BRMS1 in metastasis was studied using mice model. Our results showed that BRMS1 expression was significantly associated with clinicopathological parameters in rectal cancer patients and overexpression of BRMS1 in rectal cancer xenograft led to decreased growth, invasiveness and metastasis. Our findings indicate that high expression of BRSM1 in rectal cancer plays an essential role in tumor progression.
authors.affiliation: Department of Gastrointestinal Surgery, Shandong Tumor Hospital, Jinan, 250017, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Guan
authors.forename: Yanlai
authors.initials: Y
authors.lastname: Sun
authors.forename: Jie
authors.initials: J
authors.lastname: Chai
authors.forename: Tao
authors.initials: T
authors.lastname: Zou
authors.forename: Weipeng
authors.initials: W
authors.lastname: Gong
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhu
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Hou
authors.forename: Xilin
authors.initials: X
authors.lastname: Song
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000235:genetics; D012004:Rectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D012097:Repressor Proteins / Q000235:genetics*
chemical_list: C410024:BRMS1 protein, human; D012097:Repressor Proteins