title: Cell-mediated delivery of nanoparticles: taking advantage of circulatory cells to target nanoparticles.
abstract: Cellular hitchhiking leverages the use of circulatory cells to enhance the biological outcome of nanoparticle drug delivery systems, which often suffer from poor circulation time and limited targeting. Cellular hitchhiking utilizes the natural abilities of circulatory cells to: (i) navigate the vasculature while avoiding immune system clearance, (ii) remain relatively inert until needed and (iii) perform specific functions, including nutrient delivery to tissues, clearance of pathogens, and immune system surveillance. A variety of synthetic nanoparticles attempt to mimic these functional attributes of circulatory cells for drug delivery purposes. By combining the advantages of circulatory cells and synthetic nanoparticles, many advanced drug delivery systems have been developed that adopt the concept of cellular hitchhiking. Here, we review the development and specific applications of cellular hitchhiking-based drug delivery systems.
authors.affiliation: Department of Chemical Engineering, Center for Bioengineering, University of California, Santa Barbara 93106, USA.
authors.forename: Aaron C
authors.initials: AC
authors.lastname: Anselmo
authors.affiliation: Department of Chemical Engineering, Center for Bioengineering, University of California, Santa Barbara 93106, USA. Electronic address: samir@engineering.ucsb.edu.
authors.forename: Samir
authors.initials: S
authors.lastname: Mitragotri
mesh_terms: D000818:Animals; D002477:Cells / Q000378:metabolism*; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism
keywords: Blood; Cell-mediated drug delivery; Cellular hitchhiking; Nanomedicine; Nanoparticles; Nanotechnology
references.citation: Nat Rev Cancer. 2003 Sep;3(9):666-75
references.pmid: 12951585
references.citation: J Control Release. 2004 Nov 5;100(1):111-9
references.pmid: 15491815
references.citation: Science. 2006 Oct 6;314(5796):126-9
references.pmid: 16946036
references.citation: Nanomedicine (Lond). 2010 Apr;5(3):379-96
references.pmid: 20394532
references.citation: J Drug Target. 2005 Feb;13(2):99-111
references.pmid: 15823961
references.citation: Exp Biol Med (Maywood). 2007 Jul;232(7):958-66
references.pmid: 17609513
references.citation: Biomacromolecules. 2010 Jul 12;11(7):1826-32
references.pmid: 20527876
references.citation: Adv Mater. 2011 Mar 25;23(12):H105-9
references.pmid: 21365691
references.citation: Nat Nanotechnol. 2007 Dec;2(12):751-60
references.pmid: 18654426
references.citation: Nat Rev Immunol. 2011 Oct 10;11(11):762-74
references.pmid: 21984070
references.citation: Nat Med. 2004 Sep;10(9):909-15
references.pmid: 15340416
references.citation: Nat Rev Immunol. 2007 Oct;7(10):790-802
references.pmid: 17853902
references.citation: ACS Nano. 2008 Jan;2(1):85-96
references.pmid: 19206551
references.citation: Cell Mol Biol Lett. 2002;7(2):286
references.pmid: 12097957
references.citation: ACS Nano. 2013 Dec 23;7(12):11129-37
references.pmid: 24182189
references.citation: Nat Med. 1995 Dec;1(12):1297-302
references.pmid: 7489412
references.citation: Cancer Nanotechnol. 2012 Dec;3(1-6):47-54
references.pmid: 23205151
references.citation: Nat Rev Immunol. 2012 Mar 22;12(4):269-81
references.pmid: 22437939
references.citation: Nat Rev Immunol. 2002 Jun;2(6):401-9
references.pmid: 12093006
references.citation: Drug Deliv. 2003 Jan-Mar;10(1):9-20
references.pmid: 12554359
references.citation: Nat Rev Cancer. 2008 Apr;8(4):299-308
references.pmid: 18354418
references.citation: J Pharmacol Exp Ther. 2000 Mar;292(3):1071-9
references.pmid: 10688625
references.citation: Nano Lett. 2008 Dec;8(12):4446-53
references.pmid: 19367972
references.citation: J Clin Invest. 2007 Jun;117(6):1466-76
references.pmid: 17549249
references.citation: Hematology Am Soc Hematol Educ Program. 2013;2013:234-46
references.pmid: 24319186
references.citation: Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E60-8
references.pmid: 23248266
references.citation: Antiviral Res. 2002 Dec;56(3):263-72
references.pmid: 12406509
references.citation: Nat Med. 2010 Sep;16(9):1035-41
references.pmid: 20711198
references.citation: Science. 2012 Nov 16;338(6109):903-10
references.pmid: 23161990
references.citation: Int J Pharm. 2006 Jan 3;307(1):93-102
references.pmid: 16303268
references.citation: J Cell Physiol. 2007 Nov;213(2):341-7
references.pmid: 17620285
references.citation: Biomaterials. 2012 Aug;33(23):5776-87
references.pmid: 22594972
references.citation: Adv Mater. 2012 Jul 24;24(28):3864-9
references.pmid: 22641451
references.citation: Nano Lett. 2007 Dec;7(12):3759-65
references.pmid: 17979310
references.citation: Nat Rev Immunol. 2004 Jun;4(6):432-44
references.pmid: 15173832
references.citation: Biotechnol Appl Biochem. 1993 Dec;18(3):217-26
references.pmid: 8297502
references.citation: Nat Rev Drug Discov. 2011 Jul 01;10(7):521-35
references.pmid: 21720407
references.citation: Nano Lett. 2006 Aug;6(8):1794-807
references.pmid: 16895376
references.citation: Cancer Res. 2006 Jun 1;66(11):5910-8
references.pmid: 16740731
references.citation: Pharmacol Rev. 2001 Jun;53(2):283-318
references.pmid: 11356986
references.citation: Annu Rev Med. 1999;50:507-29
references.pmid: 10073291
references.citation: Science. 2013 Feb 22;339(6122):971-5
references.pmid: 23430657
references.citation: J Immunol. 2004 Jul 15;173(2):1444-53
references.pmid: 15240741
references.citation: J Pharmacol Exp Ther. 2001 Aug;298(2):607-12
references.pmid: 11454922
references.citation: Expert Opin Drug Deliv. 2011 Apr;8(4):415-33
references.pmid: 21348773
references.citation: J Nanomed Nanotechnol. 2011 Sep 10;S4:
references.pmid: 22288024
references.citation: Nano Today. 2011 Jun 1;6(3):309-325
references.pmid: 21826117
references.citation: Adv Drug Deliv Rev. 2008 Jan 14;60(2):286-95
references.pmid: 17997501
references.citation: Biotechnol Appl Biochem. 2001 Apr;33(2):85-9
references.pmid: 11277860
references.citation: Nat Nanotechnol. 2013 Jan;8(1):61-8
references.pmid: 23241654
references.citation: Nat Rev Drug Discov. 2010 Aug;9(8):615-27
references.pmid: 20616808
references.citation: Biomacromolecules. 2010 Sep 13;11(9):2407-14
references.pmid: 20795701
references.citation: Expert Opin Drug Deliv. 2010 Apr;7(4):403-27
references.pmid: 20192900
references.citation: Nat Biotechnol. 2003 Aug;21(8):891-6
references.pmid: 12845330
references.citation: Am J Sports Med. 2009 Nov;37(11):2259-72
references.pmid: 19875361
references.citation: Blood. 2008 Sep 1;112(5):1570-80
references.pmid: 18725575
references.citation: Vaccine. 1997 Feb;15(3):276-80
references.pmid: 9139486
references.citation: Transfusion. 1990 May;30(4):358-62
references.pmid: 2190368
references.citation: Biotechnol Appl Biochem. 1996 Feb;23(1):29-36
references.pmid: 8867894
references.citation: Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):10980-5
references.pmid: 21690347
references.citation: Biomaterials. 2012 Jun;33(16):4195-203
references.pmid: 22398206
references.citation: Nature. 2011 Dec 21;480(7378):480-9
references.pmid: 22193102
references.citation: J Immunol. 2009 Jul 1;183(1):661-9
references.pmid: 19535632
references.citation: Annu Rev Immunol. 1989;7:145-73
references.pmid: 2523712
references.citation: J Immunother. 2011 May;34(4):343-52
references.pmid: 21499127
references.citation: Nat Med. 2005 Oct;11(10):1073-81
references.pmid: 16170322
references.citation: J Orthop Res. 2007 Jan;25(1):81-91
references.pmid: 17031861
references.citation: Blood. 2004 Oct 15;104(8):2224-34
references.pmid: 15231578
references.citation: Pharmacol Rev. 1997 Sep;49(3):279-95
references.pmid: 9311024
references.citation: J Cell Physiol. 1971 Apr;77(2):179-86
references.pmid: 4102021
references.citation: Cell Mol Immunol. 2013 May;10(3):230-52
references.pmid: 23604045
references.citation: Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21495-9
references.pmid: 20018694
references.citation: Annu Rev Immunol. 2004;22:745-63
references.pmid: 15032595
references.citation: Nat Rev Immunol. 2005 Dec;5(12):953-64
references.pmid: 16322748
references.citation: J Control Release. 2013 Nov 28;172(1):38-47
references.pmid: 23933235
references.citation: Bioconjug Chem. 2007 Sep-Oct;18(5):1498-506
references.pmid: 17760417
references.citation: Nat Med. 1996 Jan;2(1):52-8
references.pmid: 8564842
references.citation: Thromb Haemost. 1997 Jul;78(1):611-6
references.pmid: 9198225