title: Successful salvage of complicated calcaneal blastomycosis in disseminated disease with staged surgical reconstruction and local-systemic antifungal therapy.
abstract: Disseminated blastomycosis can be a devastating disease, affecting multiple organ systems, including the musculoskeletal system. Osteomyelitis from disseminated disease can be difficult to eradicate but is particularly important to successfully manage in the load-bearing bones of the lower extremity. We present a staged protocol for salvage of blastomycotic calcaneal osteomyelitis in the presence of disseminated disease.
authors.affiliation: Department of Orthopaedics, Marshfield Clinic, Marshfield, WI. Electronic address: bibbo.christopher@marshfieldclinic.org.
authors.forename: Christopher
authors.initials: C
authors.lastname: Bibbo
authors.affiliation: Department of Infectious Disease, Marshfield Clinic, Marshfield, WI.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Spellman
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001759:Blastomycosis / Q000628:therapy*; D002111:Calcaneus / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D010019:Osteomyelitis / Q000628:therapy*; D019651:Plastic Surgery Procedures; D016879:Salvage Therapy; D013203:Staphylococcal Infections / Q000382:microbiology / Q000628:therapy*
chemical_list: D000935:Antifungal Agents
keywords: amphotericin-B; calcaneus; fungal infection; iliac crest bone graft; organ failure; osteomyelitis; voriconazole