title: A new life for an old pump: V-ATPase and neurotransmitter release.
abstract: Neurons fire by releasing neurotransmitters via fusion of synaptic vesicles with the plasma membrane. Fusion can be evoked by an incoming signal from a preceding neuron or can occur spontaneously. Synaptic vesicle fusion requires the formation of trans complexes between SNAREs as well as Ca(2+) ions. Wang et al. (2014. J. Cell Biol. http://dx.doi.org/jcb.201312109) now find that the Ca(2+)-binding protein Calmodulin promotes spontaneous release and SNARE complex formation via its interaction with the V0 sector of the V-ATPase.
authors.affiliation: Département de Biochimie, Université de Lausanne, 1066 Epalinges, Switzerland.
authors.forename: Stefano
authors.initials: S
authors.lastname: Vavassori
authors.forename: Andreas
authors.initials: A
authors.lastname: Mayer
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000201:enzymology*; D009469:Neuromuscular Junction / Q000201:enzymology*; D050765:Qa-SNARE Proteins / Q000378:metabolism*; D009435:Synaptic Transmission; D013572:Synaptic Vesicles / Q000201:enzymology*; D025262:Vacuolar Proton-Translocating ATPases / Q000378:metabolism*
chemical_list: D002147:Calmodulin; D029721:Drosophila Proteins; D050765:Qa-SNARE Proteins; C578392:syntaxin, Drosophila; D025262:Vacuolar Proton-Translocating ATPases; C550849:Vha100-1 protein, Drosophila; D002118:Calcium
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