title: Signaling by epithelial members of the CEACAM family - mucosal docking sites for pathogenic bacteria.
abstract: Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) comprise a group of immunoglobulin-related vertebrate glycoproteins. Several family members, including CEACAM1, CEA, and CEACAM6, are found on epithelial tissues throughout the human body. As they modulate diverse cellular functions, their signaling capacity is in the focus of current research. In this review we will summarize the knowledge about common signaling processes initiated by epithelial CEACAMs and suggest a model of signal transduction by CEACAM family members lacking significant cytoplasmic domains. As pathogenic and non-pathogenic bacteria exploit these receptors during mucosal colonization, we try to highlight the connection between CEACAMs, microbes, and cellular responses. Special emphasis in this context is placed on the functional interplay between CEACAMs and integrins that influences matrix adhesion of epithelial cells. The cooperation between these two receptor families provides an intriguing example of the fine tuning of cellular responses and their manipulation by specialized microorganisms.
authors.forename: Arnaud Kengmo
authors.initials: AK
authors.lastname: Tchoupa
authors.forename: Tamara
authors.initials: T
authors.lastname: Schuhmacher
authors.affiliation: Lehrstuhl für Zellbiologie, Universität Konstanz, 78457 Konstanz, Germany. christof.hauck@uni-konstanz.de.
authors.forename: Christof R
authors.initials: CR
authors.lastname: Hauck
mesh_terms: D018829:Adhesins, Bacterial / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000378:metabolism*; D058851:GPI-Linked Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D021962:Membrane Microdomains / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D018829:Adhesins, Bacterial; D015815:Cell Adhesion Molecules; D058851:GPI-Linked Proteins
references.citation: Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4218-23
references.pmid: 21368133
references.citation: Curr Opin Cell Biol. 1997 Oct;9(5):616-26
references.pmid: 9330864
references.citation: Curr Opin Cell Biol. 2006 Oct;18(5):565-71
references.pmid: 16919437
references.citation: Infect Immun. 2004 May;72(5):2742-52
references.pmid: 15102784
references.citation: Blood. 2005 May 15;105(10):3925-34
references.pmid: 15687237
references.citation: Cell Microbiol. 2001 Jan;3(1):33-44
references.pmid: 11207618
references.citation: Mol Microbiol. 1997 Dec;26(5):971-80
references.pmid: 9426134
references.citation: Arch Biochem Biophys. 2012 Aug 1;524(1):77-83
references.pmid: 22469950
references.citation: J Cell Sci. 2010 Dec 15;123(Pt 24):4280-91
references.pmid: 21098633
references.citation: Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):521-6
references.pmid: 12522268
references.citation: Genomics. 1994 Oct;23(3):669-84
references.pmid: 7851896
references.citation: J Clin Invest. 2007 Jun;117(6):1566-74
references.pmid: 17525800
references.citation: Mol Cell. 2000 Feb;5(2):311-20
references.pmid: 10882072
references.citation: PLoS One. 2010 Apr 09;5(4):e10067
references.pmid: 20404914
references.citation: Cancer Res. 2010 Oct 15;70(20):8159-68
references.pmid: 20889724
references.citation: J Clin Invest. 2006 Jun;116(6):1596-605
references.pmid: 16680193
references.citation: Cancer Res. 1994 Aug 1;54(15):4169-76
references.pmid: 8033149
references.citation: BMC Evol Biol. 2007 Oct 18;7:196
references.pmid: 17945019
references.citation: Am J Pathol. 2001 Aug;159(2):537-46
references.pmid: 11485912
references.citation: Mol Cancer. 2008 May 28;7:46
references.pmid: 18507857
references.citation: Cancer Res. 2005 Dec 1;65(23):11010-7
references.pmid: 16322250
references.citation: Mol Microbiol. 1998 Nov;30(3):657-71
references.pmid: 9822830
references.citation: Nat Rev Immunol. 2006 Jun;6(6):433-46
references.pmid: 16724098
references.citation: J Cell Biol. 2000 Aug 7;150(3):613-26
references.pmid: 10931872
references.citation: Oncogene. 2006 Sep 7;25(40):5527-36
references.pmid: 16619040
references.citation: Int J Breast Cancer. 2011;2011:381080
references.pmid: 22332010
references.citation: Cell Microbiol. 2008 May;10(5):1074-92
references.pmid: 18081725
references.citation: Infect Immun. 1991 Jun;59(6):2051-7
references.pmid: 1674739
references.citation: J Cell Biol. 1993 Aug;122(4):951-60
references.pmid: 8349740
references.citation: Mol Microbiol. 2001 Feb;39(4):850-62
references.pmid: 11251807
references.citation: Mol Microbiol. 2000 May;36(4):784-95
references.pmid: 10844667
references.citation: Cancer Metastasis Rev. 2013 Dec;32(3-4):643-71
references.pmid: 23903773
references.citation: Oncogene. 2007 Dec 6;26(55):7637-46
references.pmid: 17546042
references.citation: J Cell Sci. 1999 Dec;112 ( Pt 23):4193-205
references.pmid: 10564638
references.citation: PLoS Pathog. 2013;9(7):e1003509
references.pmid: 23935487
references.citation: J Biol Chem. 2013 Oct 11;288(41):29654-69
references.pmid: 24005674
references.citation: Infect Immun. 2009 Jan;77(1):517-31
references.pmid: 19015254
references.citation: Science. 2004 Feb 6;303(5659):839-42
references.pmid: 14764880
references.citation: Infect Immun. 2008 Nov;76(11):5322-9
references.pmid: 18678656
references.citation: Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14851-6
references.pmid: 8962144
references.citation: BMC Biol. 2010 Feb 04;8:12
references.pmid: 20132533
references.citation: Cancer Res. 2000 Mar 1;60(5):1236-44
references.pmid: 10728682
references.citation: Mol Microbiol. 1996 Dec;22(5):941-50
references.pmid: 8971715
references.citation: Infect Immun. 2008 Sep;76(9):3869-80
references.pmid: 18559426
references.citation: Oncogene. 2008 Mar 6;27(11):1545-53
references.pmid: 17891182
references.citation: Blood. 1995 Dec 15;86(12):4389-99
references.pmid: 8541526
references.citation: J Exp Med. 2004 Jan 5;199(1):35-46
references.pmid: 14707113
references.citation: J Biol Chem. 2011 Mar 18;286(11):9555-66
references.pmid: 21216968
references.citation: Infect Immun. 2008 Jan;76(1):48-55
references.pmid: 17938212
references.citation: Mol Microbiol. 2003 Apr;48(1):117-29
references.pmid: 12657049
references.citation: Exp Cell Res. 1999 Nov 1;252(2):243-9
references.pmid: 11501563
references.citation: J Cell Biol. 2005 Aug 29;170(5):825-36
references.pmid: 16115956
references.citation: J Cell Biol. 2006 Nov 20;175(4):647-59
references.pmid: 17101695
references.citation: Mol Microbiol. 2004 May;52(4):963-83
references.pmid: 15130118
references.citation: J Cell Biol. 2009 Nov 16;187(4):569-81
references.pmid: 19948503
references.citation: Cancer Res. 2007 May 15;67(10):4774-82
references.pmid: 17510406
references.citation: J Cell Physiol. 2007 Jun;211(3):791-802
references.pmid: 17286276
references.citation: Mol Ther. 2004 Jun;9(6):775-85
references.pmid: 15194045
references.citation: Nat Immunol. 2008 Nov;9(11):1270-8
references.pmid: 18836450
references.citation: J Cell Sci. 2005 Dec 1;118(Pt 23):5513-24
references.pmid: 16291724
references.citation: J Biol Chem. 1993 Nov 15;268(32):24303-10
references.pmid: 8226979
references.citation: J Cell Physiol. 2007 Mar;210(3):757-65
references.pmid: 17167768
references.citation: Blood. 2009 Feb 19;113(8):1818-28
references.pmid: 19008452
references.citation: J Biol Chem. 2014 Jan 31;289(5):2934-45
references.pmid: 24302721
references.citation: PLoS One. 2010 Jan 18;5(1):e8747
references.pmid: 20090913
references.citation: Science. 2010 Sep 3;329(5996):1197-201
references.pmid: 20813953
references.citation: J Biol Chem. 2007 Feb 23;282(8):5749-60
references.pmid: 17192268
references.citation: J Cell Biol. 1996 Dec;135(5):1249-60
references.pmid: 8947549
references.citation: J Leukoc Biol. 2009 Aug;86(2):205-18
references.pmid: 19454653
references.citation: Exp Cell Res. 1996 Sep 15;227(2):360-6
references.pmid: 8831574
references.citation: PLoS One. 2013;8(1):e53359
references.pmid: 23358633
references.citation: Semin Cancer Biol. 1999 Apr;9(2):67-81
references.pmid: 10202129
references.citation: Mol Microbiol. 1996 Dec;22(5):929-39
references.pmid: 8971714
references.citation: Infect Immun. 2007 Aug;75(8):4116-26
references.pmid: 17517873
references.citation: Exp Cell Res. 2009 Apr 15;315(7):1225-33
references.pmid: 19146852
references.citation: Eur J Immunol. 2005 Jun;35(6):1949-59
references.pmid: 15909305
references.citation: Nat Rev Microbiol. 2009 Apr;7(4):274-86
references.pmid: 19287450
references.citation: PLoS One. 2012;7(3):e32808
references.pmid: 22448228
references.citation: Blood. 2001 Sep 1;98(5):1469-79
references.pmid: 11520797
references.citation: Genomics. 2005 Nov;86(5):566-80
references.pmid: 16139472
references.citation: Blood. 1994 Jul 1;84(1):211-9
references.pmid: 7517208
references.citation: Cancer Res. 1997 Jul 1;57(13):2781-8
references.pmid: 9205090
references.citation: J Exp Med. 1965 Sep 1;122(3):467-81
references.pmid: 4953873
references.citation: J Mol Histol. 2004 Mar;35(3):287-99
references.pmid: 15339048
references.citation: PLoS One. 2012;7(6):e39908
references.pmid: 22768164
references.citation: PLoS One. 2012;7(1):e29606
references.pmid: 22235309
references.citation: Mol Cell Biol. 1993 Feb;13(2):1273-82
references.pmid: 8423792
references.citation: Gene. 2004 Sep 15;339:99-109
references.pmid: 15363850
references.citation: J Cell Biol. 2009 Nov 16;187(4):553-67
references.pmid: 19948502
references.citation: Cancer Res. 1993 Aug 15;53(16):3817-22
references.pmid: 7687926
references.citation: Cell. 1989 Apr 21;57(2):327-34
references.pmid: 2702691
references.citation: J Exp Med. 1997 May 5;185(9):1557-64
references.pmid: 9151893