title: [Clinical evaluation of lapatinib therapy in metastatic breast cancer using the Bayes meta-analysis].
abstract: The efficacy of treatments involving lapatinib for patients with metastatic breast cancers was evaluated in a Bayesian metaanalysis of published data from randomized controlled clinical trials. Four randomized controlled trials including 2,708 patients met the inclusion criteria. Among these patients, 568 were positive for the human epidermal growth factor receptor 2(HER2). The clinical benefit rate(CBR)for HER2-positive patients was the primary outcome of the analysis, and the overall survival(l OS) and the number needed to treat(NNT)were the secondary outcomes of the reported meta-analysis. The Bayesian metaanalysis was conducted according to the Markov-chain Monte-Carlo technique in WinBUGS. The CBR for HER2-positive patients was significantly improved(odds ratio[OR]: 2.281, 95% confidence interval[CI]: 1.490-3.628), whereas no statistically significant improvement was seen in the overall patient CBR(OR: 1.559, 95% CI: 0.768-3.238). The OS hazard ratio (HR)and NNT for the CBR were also estimated for HER2-positive patients. The difference in the OS HR was not statistically significant(HR: 0.789, 95% CI: 0.556-1.086)for HER2-positive patients. The improvement in the NNT for the CBR was statistically significant(NNT 5.164, 95% CI: 3.803-8.723)for HER2-positive patients.
authors.affiliation: Dept. of Hospital Administration, Tokyo Women's Medical University.
authors.forename: Tadao
authors.initials: T
authors.lastname: Inoue
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Iyoda
authors.forename: Wataru
authors.initials: W
authors.lastname: Yamamoto
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Uetsuka
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001499:Bayes Theorem; D001943:Breast Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D000077341:Lapatinib; D009362:Neoplasm Metastasis; D011799:Quinazolines / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000077341:Lapatinib; D011799:Quinazolines; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human