title: Automatic clustering and population analysis of white matter tracts using maximum density paths.
abstract: We introduce a framework for population analysis of white matter tracts based on diffusion-weighted images of the brain. The framework enables extraction of fibers from high angular resolution diffusion images (HARDI); clustering of the fibers based partly on prior knowledge from an atlas; representation of the fiber bundles compactly using a path following points of highest density (maximum density path; MDP); and registration of these paths together using geodesic curve matching to find local correspondences across a population. We demonstrate our method on 4-Tesla HARDI scans from 565 young adults to compute localized statistics across 50 white matter tracts based on fractional anisotropy (FA). Experimental results show increased sensitivity in the determination of genetic influences on principal fiber tracts compared to the tract-based spatial statistics (TBSS) method. Our results show that the MDP representation reveals important parts of the white matter structure and considerably reduces the dimensionality over comparable fiber matching approaches.
authors.affiliation: Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Laboratory of Neuro Imaging, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA.
authors.forename: Gautam
authors.initials: G
authors.lastname: Prasad
authors.affiliation: Department of Neurology, University of California Los Angeles, CA, USA.
authors.forename: Shantanu H
authors.initials: SH
authors.lastname: Joshi
authors.affiliation: Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Laboratory of Neuro Imaging, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA.
authors.forename: Neda
authors.initials: N
authors.lastname: Jahanshad
authors.affiliation: Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Laboratory of Neuro Imaging, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA.
authors.forename: Julio
authors.initials: J
authors.lastname: Villalon-Reina
authors.affiliation: Martinos Center for Biomedical Imaging, Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Iman
authors.initials: I
authors.lastname: Aganj
authors.affiliation: Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Christophe
authors.initials: C
authors.lastname: Lenglet
authors.affiliation: Dept. of Electrical and Computer Engineering, Computer Science, Duke University, NC, USA; Dept. of Biomedical Engineering, Duke University, NC, USA.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Sapiro
authors.affiliation: Center for Advanced Imaging, University of Queensland, Brisbane, Australia.
authors.forename: Katie L
authors.initials: KL
authors.lastname: McMahon
authors.affiliation: School of Psychology, University of Queensland, Brisbane, Australia.
authors.forename: Greig I
authors.initials: GI
authors.lastname: de Zubicaray
authors.affiliation: QIMR Berghofer Medical Research Institute, Herston, Australia.
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.affiliation: School of Psychology, University of Queensland, Brisbane, Australia; QIMR Berghofer Medical Research Institute, Herston, Australia.
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Wright
authors.affiliation: Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Laboratory of Neuro Imaging, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Dept. of Neurology, Psychiatry, Engineering, Radiology, University of Southern California, Los Angeles, CA, USA; Dept. of Ophthalmology, University of Southern California, Los Angeles, CA, USA.
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
authors.affiliation: Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Laboratory of Neuro Imaging, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Department of Neurology, University of California Los Angeles, CA, USA; Dept. of Neurology, Psychiatry, Engineering, Radiology, University of Southern California, Los Angeles, CA, USA; Dept. of Ophthalmology, University of Southern California, Los Angeles, CA, USA; Department of Pediatrics, University of Southern California, Los Angeles, CA, USA. Electronic address: pthomp@usc.edu.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D016000:Cluster Analysis; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D009412:Nerve Fibers; D009434:Neural Pathways / Q000033:anatomy & histology / Q000166:cytology; D015203:Reproducibility of Results; D066127:White Matter / Q000033:anatomy & histology* / Q000166:cytology; D055815:Young Adult
keywords: Atlas; Brain; Clustering; Connectivity; Curve registration; Dijkstra; Geodesic distance; HARDI; Hough; Longest path; MRI; Maximum density path; Shortest path; Tractography
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