title: Kawasaki disease: pathophysiology, clinical manifestations, and management.
abstract: Kawasaki Disease, a systemic vasculitis of unknown origin with specific predilection for the coronary arteries, is the most common cause of childhood-acquired heart disease in western countries. Despite its world-wide incidence, the pathophysiology of this enigmatic disease is still under investigation. Diagnosis is made on a clinical basis, with supportive laboratory evidence and imaging. Once identified, timely initiation of treatment is imperative in order to quell the inflammatory response and decrease the incidence of long-term sequelae, specifically coronary artery aneurysms. Finally, longitudinal follow-up should be implemented based on risk stratification and individualized to each patient.
authors.affiliation: Division of Pediatric Rheumatology, Departments of Pediatrics, LSU Health Sciences Center and Children's Hospital, New Orleans, LA, USA.
authors.forename: Victoria R
authors.initials: VR
authors.lastname: Dimitriades
authors.forename: Amanda G
authors.initials: AG
authors.lastname: Brown
authors.forename: Abraham
authors.initials: A
authors.lastname: Gedalia
mesh_terms: D003323:Coronary Aneurysm / Q000209:etiology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D014409:Tumor Necrosis Factor-alpha
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