title: Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass.
abstract: Considerable debate and controversy surround the cause(s) of Alzheimer's disease (AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD.
authors.affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Bonda
authors.forename: Xinglong
authors.initials: X
authors.lastname: Wang
authors.forename: Hyoung-Gon
authors.initials: HG
authors.lastname: Lee
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: George
authors.initials: G
authors.lastname: Perry
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology*; D006801:Humans; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D018384:Oxidative Stress / Q000502:physiology*
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