title: [Acute cough in infants: impact on families and pharmacists of contraindications of the Agence nationale de sécurité du médicament et des produits de santé (ANSM)].
abstract: OBJECTIVE
  Although commonplace and usually not serious, acute cough in the context of upper respiratory tract infection is a frequent reason for consultation and generates significant parental anxiety. Parents often request active drug intervention. Following the contraindications in infants of mucolytics, Hélicidine(®), antihistamines, and terpene-based suppositories, issued between 2010 and 2011 by the Agence nationale de sécurité du médicament et des produits de santé (ANSM), we wished to assess whether these contraindications were known by parents and applied in pharmacies.
  
  
  METHODS
  An assessment of compliance with these contraindications was made by a double declarative prospective observational study in Nice, first with 29 pharmacists and pharmacy technicians (4-25 August 2012) and then with 289 parents of infants (December 2011 to April 2012).
  
  
  RESULTS
  The rate of noncompliance with contraindications was 23.8 % for parents and 34.5 % of pharmacists and pharmacy technicians. Consumption of cough medicines was inversely correlated to the ability to perform a correct nasal wash (OR=2.3). Only 21 % of parents used nasal wash properly. Full-time work was a risk factor for noncompliance with contraindications (OR=1.91).
  
  
  CONCLUSIONS
  ANSM contraindications still have a limited impact on pharmacists and families. Therefore, efforts must be pursued to stop delivering cough medicines for infants. The information and educational campaigns should also involve parents and help to improve nasal wash use.
authors.affiliation: Médecine pédiatrique, pneumo-allergologie pédiatrique, hôpitaux pédiatriques de Nice, CHU Lenval, 57, avenue de la Californie, 06200 Nice, France. Electronic address: fabienalauzet@hotmail.com.
authors.forename: F
authors.initials: F
authors.lastname: Alauzet
authors.affiliation: Médecine pédiatrique, pneumo-allergologie pédiatrique, hôpitaux pédiatriques de Nice, CHU Lenval, 57, avenue de la Californie, 06200 Nice, France.
authors.forename: S
authors.initials: S
authors.lastname: Blanc
authors.affiliation: Urgences pédiatriques, pneumo-allergologie pédiatrique, hôpitaux pédiatriques de Nice, CHU Lenval, 57, avenue de la Californie, 06200 Nice, France.
authors.forename: I
authors.initials: I
authors.lastname: Montaudié
authors.affiliation: Urgences pédiatriques, pneumo-allergologie pédiatrique, hôpitaux pédiatriques de Nice, CHU Lenval, 57, avenue de la Californie, 06200 Nice, France.
authors.forename: C
authors.initials: C
authors.lastname: Piccini-Bailly
authors.affiliation: Médecine pédiatrique, pneumo-allergologie pédiatrique, hôpitaux pédiatriques de Nice, CHU Lenval, 57, avenue de la Californie, 06200 Nice, France.
authors.forename: M
authors.initials: M
authors.lastname: Berlioz-Baudoin
authors.affiliation: Médecine pédiatrique, pneumo-allergologie pédiatrique, hôpitaux pédiatriques de Nice, CHU Lenval, 57, avenue de la Californie, 06200 Nice, France.
authors.forename: M
authors.initials: M
authors.lastname: Bégassat
authors.affiliation: Médecine pédiatrique, pneumo-allergologie pédiatrique, hôpitaux pédiatriques de Nice, CHU Lenval, 57, avenue de la Californie, 06200 Nice, France.
authors.forename: M
authors.initials: M
authors.lastname: Albertini
authors.affiliation: Médecine pédiatrique, pneumo-allergologie pédiatrique, hôpitaux pédiatriques de Nice, CHU Lenval, 57, avenue de la Californie, 06200 Nice, France.
authors.forename: L
authors.initials: L
authors.lastname: Giovannini-Chami
mesh_terms: D000996:Antitussive Agents / Q000009:adverse effects / Q000627:therapeutic use; D001291:Attitude of Health Personnel; D000075202:Contraindications; D003371:Cough / Q000188:drug therapy*; D005100:Expectorants / Q000009:adverse effects / Q000627:therapeutic use; D005602:France; D019983:Guideline Adherence; D057220:Health Literacy; D006633:Histamine Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D055556:Nasal Lavage / Q000523:psychology; D010290:Parents / Q000193:education* / Q000523:psychology; D010595:Pharmacists / Q000523:psychology; D011446:Prospective Studies; D013488:Suppositories; D013729:Terpenes / Q000009:adverse effects / Q000627:therapeutic use; D014020:Tissue Extracts / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000996:Antitussive Agents; D005100:Expectorants; D006633:Histamine Antagonists; D013488:Suppositories; D013729:Terpenes; D014020:Tissue Extracts; C118524:helicidine