title: Skull base embryology: a multidisciplinary review.
abstract: BACKGROUND
  The skull base represents a central and complex bone structure of the skull and forms the floor of the cranial cavity on which the brain lies. Anatomical knowledge of this particular region is important for understanding several pathologic conditions as well as for planning surgical procedures. Embryology of the cranial base is of great interest due to its pronounced impact on the development of adjacent regions including the brain, neck, and craniofacial skeleton.
  
  
  METHODS
  Information from human and comparative anatomy, anthropology, embryology, surgery, and computed modelling was integrated to provide a perspective to interpret skull base formation and variability within the cranial functional and structural system.
  
  
  CONCLUSIONS
  The skull base undergoes an elaborate sequence of development stages and represents a key player in skull, face and brain development. Furthering our holistic understanding of the embryology of the skull base promises to expand our knowledge and enhance our ability to treat associated anomalies.
authors.affiliation: Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, ON, Canada, M5B 1W8, diieva@hotmail.com.
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Ieva
authors.forename: Emiliano
authors.initials: E
authors.lastname: Bruner
authors.forename: Thomas
authors.initials: T
authors.lastname: Haider
authors.forename: Luigi F
authors.initials: LF
authors.lastname: Rodella
authors.forename: John M
authors.initials: JM
authors.lastname: Lee
authors.forename: Michael D
authors.initials: MD
authors.lastname: Cusimano
authors.forename: Manfred
authors.initials: M
authors.lastname: Tschabitscher
mesh_terms: D000883:Anthropology; D003198:Computer Simulation; D006801:Humans; D019291:Skull Base / Q000033:anatomy & histology* / Q000196:embryology*
references.citation: J Anat. 2005 Nov;207(5):437-46
references.pmid: 16313386
references.citation: Pediatr Dev Pathol. 2004 Nov-Dec;7(6):601-6
references.pmid: 15630528
references.citation: J Hum Evol. 2003 Feb;44(2):167-87
references.pmid: 12662941
references.citation: Clin Anat. 2002 Jun;15(4):297-312
references.pmid: 12112359
references.citation: Acta Otolaryngol Suppl. 1994;517:36-9
references.pmid: 7856446
references.citation: Development. 1992 Jan;114(1):1-15
references.pmid: 1576952
references.citation: J Hum Evol. 2007 Mar;52(3):262-74
references.pmid: 17097133
references.citation: J Anat Physiol. 1880 Oct;15(Pt 1):60-8
references.pmid: 17231367
references.citation: J Hum Evol. 2004 Feb;46(2):185-213
references.pmid: 14871562
references.citation: Clin Anat. 2005 Mar;18(2):92-5
references.pmid: 15696520
references.citation: Dev Biol. 2002 Jan 1;241(1):106-16
references.pmid: 11784098
references.citation: Anat Rec (Hoboken). 2009 Mar;292(3):364-70
references.pmid: 19248155
references.citation: Anat Rec A Discov Mol Cell Evol Biol. 2005 Oct;286(2):891-8
references.pmid: 16145660
references.citation: Anat Rec A Discov Mol Cell Evol Biol. 2005 May;284(1):491-9
references.pmid: 15803472
references.citation: Folia Morphol (Warsz). 2006 Nov;65(4):396-9
references.pmid: 17171622
references.citation: Dev Biol. 2006 Nov 1;299(1):272-82
references.pmid: 16935278
references.citation: Med Hypotheses. 2012 May;78(5):649-56
references.pmid: 22381659
references.citation: Am J Phys Anthropol. 2008 Sep;137(1):30-40
references.pmid: 18398846
references.citation: Plast Reconstr Surg. 2005 Oct;116(5):1363-9
references.pmid: 16217480
references.citation: Am J Phys Anthropol. 1995 Dec;98(4):575-93
references.pmid: 8599387
references.citation: J Anat. 2002 Feb;200(Pt 2):135-44
references.pmid: 11895111
references.citation: J Hum Evol. 2010 May;58(5):424-31
references.pmid: 20378153
references.citation: Dev Biol. 2012 Nov 15;371(2):203-14
references.pmid: 23009899
references.citation: J Hum Evol. 2001 Jan;40(1):41-66
references.pmid: 11139359
references.citation: Science. 1983 Apr 15;220(4594):268-73
references.pmid: 17732898
references.citation: J Anat. 2006 Nov;209(5):637-54
references.pmid: 17062021
references.citation: J Anat. 1994 Oct;185 ( Pt 2):251-8
references.pmid: 7961131
references.citation: Childs Nerv Syst. 2007 Dec;23(12):1357-65
references.pmid: 17680251
references.citation: AJNR Am J Neuroradiol. 1985 Jan-Feb;6(1):39-43
references.pmid: 3918419
references.citation: Anat Sci Int. 2006 Sep;81(3):173-80
references.pmid: 16955668
references.citation: Am J Phys Anthropol. 2002 Aug;118(4):324-40
references.pmid: 12124913
references.citation: Clin Anat. 2013 Nov;26(8):928-32
references.pmid: 23338989
references.citation: Am J Phys Anthropol. 2004 Jan;123(1):78-90
references.pmid: 14669239
references.citation: Dev Biol. 2008 Oct 1;322(1):121-32
references.pmid: 18680740
references.citation: Anat Anz. 1989;169(5):335-49
references.pmid: 2619081
references.citation: Acta Otolaryngol. 2012 Apr;132(4):349-54
references.pmid: 22201370
references.citation: Zoolog Sci. 2005 Jan;22(1):1-19
references.pmid: 15684579
references.citation: J Hum Evol. 1999 May;36(5):487-517
references.pmid: 10222166
references.citation: J Neurosurg. 1972 Feb;36(2):201-11
references.pmid: 5008734
references.citation: Am J Phys Anthropol. 2000;Suppl 31:117-69
references.pmid: 11123839
references.citation: Development. 1993 Feb;117(2):409-29
references.pmid: 8330517
references.citation: J Neurosurg. 1991 Aug;75(2):294-8
references.pmid: 2072168
references.citation: J Hum Evol. 2000 Feb;38(2):291-315
references.pmid: 10656780
references.citation: Br J Radiol. 1991 Jul;64(763):576-9
references.pmid: 1873656
references.citation: Arch Otolaryngol. 1981 Sep;107(9):550-4
references.pmid: 7271553
references.citation: Neurosurgery. 2007 Sep;61(3 Suppl):7-14; discussion 14
references.pmid: 17876228
references.citation: Asian J Neurosurg. 2012 Apr;7(2):84-6
references.pmid: 22870158
references.citation: Dev Dyn. 2006 May;235(5):1310-25
references.pmid: 16395689
references.citation: Am J Phys Anthropol. 2001 Apr;114(4):273-97
references.pmid: 11275958
references.citation: Am J Phys Anthropol. 1993 Jul;91(3):305-24
references.pmid: 8333488
references.citation: Neurosurg Rev. 2014 Jan;37(1):47-53
references.pmid: 24221055
references.citation: J Hum Evol. 1999 Nov;37(5):701-19
references.pmid: 10536088
references.citation: Dev Biol. 1978 Dec;67(2):296-312
references.pmid: 738529
references.citation: J Mol Histol. 2005 Sep;36(6-7):419-26
references.pmid: 16521043
references.citation: Clin Anat. 2004 Mar;17(2):118-22
references.pmid: 14974099
references.citation: Genes Dev. 2002 Sep 15;16(18):2365-78
references.pmid: 12231626
references.citation: Adv Otorhinolaryngol. 2013;74:1-11
references.pmid: 23257547
references.citation: Childs Nerv Syst. 2013 Jun;29(6):893-905
references.pmid: 23471493
references.citation: Clin Otolaryngol Allied Sci. 1985 Feb;10(1):21-5
references.pmid: 4006264
references.citation: Am J Phys Anthropol. 1960 Dec;18(4):281-92
references.pmid: 13773136
references.citation: Acta Anat (Basel). 1959;37:351-70
references.pmid: 14424622
references.citation: Am J Phys Anthropol. 2005 Sep;128(1):26-34
references.pmid: 15778978
references.citation: J Neurosurg. 1976 Aug;45(2):169-80
references.pmid: 939976
references.citation: Pediatr Radiol. 2006 Jul;36(7):647-62; quiz 726-7
references.pmid: 16532348
references.citation: Acta Odontol Scand. 2005 Jun;63(3):127-35
references.pmid: 16191905
references.citation: Anat Rec. 1950 Jan;106(1):1-16
references.pmid: 15404751