title: Expression of heat shock proteins (hsp) 27 and 70 in various organ systems in cases of death due to fire.
abstract: The expression of heat shock proteins (hsp) increases in case of variable types of endogenous and exogenous cellular stress, as for example thermal stress. Immunohistochemical staining with hsp antibodies can visualize these stress proteins. Fifty-three cases of death due to heat and a control group of 100 deaths without any antemortem thermic stress were examined regarding hsp27 and hsp70 expression in myocardial, pulmonary, and renal tissues. The results revealed a correlation between hsp expression, survival time, and cause of death. In cases of death due to fire, the expression of hsp is more extensive than in the control group, especially in pulmonary and renal tissues. The immunohistochemical investigation of an hsp expression can support the proof of vitality in cases of death related to fire.
authors.affiliation: Institute of Legal Medicine, University of Bonn, Stiftsplatz 12, 53111, Bonn, Germany, edoberen@uni-bonn.de.
authors.forename: E
authors.initials: E
authors.lastname: Doberentz
authors.forename: L
authors.initials: L
authors.lastname: Genneper
authors.forename: D
authors.initials: D
authors.lastname: Böker
authors.forename: E
authors.initials: E
authors.lastname: Lignitz
authors.forename: B
authors.initials: B
authors.lastname: Madea
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002056:Burns / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004848:Epithelium / Q000378:metabolism; D005260:Female; D005390:Fires; D049429:Forensic Pathology; D055551:HSP27 Heat-Shock Proteins / Q000378:metabolism*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D032342:Muscle Cells / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D012137:Respiratory System / Q000378:metabolism; D055815:Young Adult
chemical_list: D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins
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