title: The association between influenza treatment and hospitalization-associated outcomes among Korean children with laboratory-confirmed influenza.
abstract: There are limited data evaluating the relationship between influenza treatment and hospitalization duration. Our purpose assessed the association between different treatments and hospital stay among Korean pediatric influenza patients. Total 770 children ≤ 15 yr-of-age hospitalized with community-acquired laboratory-confirmed influenza at three large urban tertiary care hospitals were identified through a retrospective medical chart review. Demographic, clinical, and cost data were extracted and a multivariable linear regression model was used to assess the associations between influenza treatment types and hospital stay. Overall, there were 81% of the patients hospitalized with laboratory-confirmed influenza who received antibiotic monotherapy whereas only 4% of the patients received oseltamivir monotherapy. The mean treatment-related charges for hospitalizations treated with antibiotics, alone or with oseltamivir, were significantly higher than those treated with oseltamivir-only (P < 0.001). Influenza patients treated with antibiotics-only and antibiotics/oseltamivir combination therapy showed 44.9% and 28.2%, respectively, longer duration of hospitalization compared to those treated with oseltamivir-only. Patients treated with antibiotics, alone or combined with oseltamivir, were associated with longer hospitalization and significantly higher medical charges, compared to patients treated with oseltamivir alone. In Korea, there is a need for more judicious use of antibiotics, appropriate use of influenza rapid testing.
authors.affiliation: International Vaccine Institute, Seoul, Korea.
authors.forename: Jacqueline K
authors.identifier: 0000-0001-6744-7825
authors.initials: JK
authors.lastname: Lim
authors.affiliation: Department of Pediatric Pulmonology & Allergy, Asan Medical Center, Seoul, Korea.
authors.forename: Tae Hee
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Kilgore
authors.affiliation: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Allison E
authors.initials: AE
authors.lastname: Aiello
authors.affiliation: Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Byung Min
authors.identifier: 0000-0003-0931-2353
authors.initials: BM
authors.lastname: Choi
authors.affiliation: Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Kwang Chul
authors.identifier: 0000-0003-3552-8721
authors.initials: KC
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Kee Hwan
authors.identifier: 0000-0001-6490-4293
authors.initials: KH
authors.lastname: Yoo
authors.affiliation: Department of Pediatrics, Inje College of Medicine, Seoul, Korea.
authors.forename: Young-Hwan
authors.identifier: 0000-0001-6355-9440
authors.initials: YH
authors.lastname: Song
authors.affiliation: Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Yun-Kyung
authors.identifier: 0000-0003-4396-8671
authors.initials: YK
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000956:Antigens, Viral / Q000032:analysis / Q000276:immunology; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003710:Demography; D004359:Drug Therapy, Combination; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009980:Influenza A virus / Q000378:metabolism; D009981:Influenza B virus / Q000378:metabolism; D007251:Influenza, Human / Q000188:drug therapy*; D008297:Male; D053139:Oseltamivir / Q000627:therapeutic use*; D056910:Republic of Korea; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D000956:Antigens, Viral; D000998:Antiviral Agents; D053139:Oseltamivir
keywords: Child; Hospitalizations; Influenza, Human; Oseltamivir; Therapeutics
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