title: Quantitative Measurement of Dissection Resistance in Intimal and Medial Layers of Human Coronary Arteries.
abstract: The left anterior descending (LAD) coronary artery is the most frequently involved vessel in coronary artery dissection, a cause of acute coronary syndrome or sudden cardiac death. The biomechanical mechanisms underlying arterial dissection are not well understood. This study investigated the dissection properties of LAD specimens harvested from explanted hearts at the time of cardiac transplantation, from patients with primary dilated cardiomyopathy (n=12). Using a previously validated approach uniquely modified for these human LAD specimens, we quantified the local energy release rate,G, within different arterial layers during experimental dissection events (tissue tearing). Results show that the mean values ofGduring arterial dissection within the intima and within the media in human LADs are 20.7±16.5 J/m2and 10.3±5.0 J/m2, respectively. The difference in dissection resistance between tearing events occurring within the intima and within the media is statistically significant. Our data fall in the same order of magnitude as most previous measurements of adhesive strength in other human arteries, with the differences in measured values ofGwithin the layers most likely due to histologically observed differences in the structure and composition of arterial layers.
authors.affiliation: Biomedical Engineering Program, University of South Carolina, Columbia, SC.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC.
authors.forename: John A
authors.initials: JA
authors.lastname: Johnson
authors.affiliation: Biomedical Engineering Program, University of South Carolina, Columbia, SC ; Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC ; Cardiovascular Translational Research Center, University of South Carolina School of Medicine, and WJB Dorn Veteran Affairs Medical Center, Columbia, SC.
authors.forename: Francis G
authors.initials: FG
authors.lastname: Spinale
authors.affiliation: Biomedical Engineering Program, University of South Carolina, Columbia, SC ; Department of Mechanical Engineering, University of South Carolina, Columbia, SC.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Sutton
authors.affiliation: Biomedical Engineering Program, University of South Carolina, Columbia, SC ; Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Lessner
keywords: arterial dissection; coronary artery; energy release rate; intima; media; peeling experiments
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