title: microRNA expression patterns across seven cancers are highly correlated and dominated by evolutionarily ancient families.
abstract: microRNAs (miRNAs) are involved in almost all normal and pathogenic eukaryotic cell processes. One area in which the influence of miRNAs is most prominent is cancer. Numerous expression surveys and more focused studies have revealed miRNA involvement in carcinogenesis, cellular pathology, cell behavior and prognosis. Large-scale comparisons of miRNA expression in varioius types of cancer have not been previously possible. However, The Cancer Genome Atlas (TCGA), an extensive multi-centered effort to characterize the genomes of hundreds of types of cancer, has enabled such comparisons. In the present study, the expression patterns of hundreds of miRNAs in thousands of tumors covering seven types of cancer: uterine corpus adenocarcinoma, ovarian serous adenocarcinoma, breast adenocarcinoma, prostate adenocarcinoma, pancreatic adenocarcinoma, colorectal adenocarcinoma, and lung adenocarcinoma were analyzed. The results showed that miRNA expression patterns among these cancer types are highly correlated (0.874>ρ>0.974) and that miRNA expression in all seven cancer types is dominated by miRNAs belonging to the most evolutionarily ancient miRNA families. This raises the possibility that more ancient miRNAs are involved in the fundamental cell processes that are central to tumor evolution.
authors.affiliation: Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Devor
authors.affiliation: Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
authors.forename: Brandon M
authors.initials: BM
authors.lastname: Schickling
authors.affiliation: Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA ; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
authors.forename: Kimberly K
authors.initials: KK
authors.lastname: Leslie
keywords: The Cancer Genome Atlas; microRNA; rank correlation
references.citation: Nat Commun. 2014;5:3231
references.pmid: 24488081
references.citation: Oncol Rep. 2011 Oct;26(4):995-1002
references.pmid: 21725615
references.citation: Nat Commun. 2013;4:2730
references.pmid: 24220575
references.citation: Nat Protoc. 2009;4(1):44-57
references.pmid: 19131956
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2946-50
references.pmid: 18287013
references.citation: J Exp Zool B Mol Dev Evol. 2006 Nov 15;306(6):575-88
references.pmid: 16838302
references.citation: Curr Opin Genet Dev. 2013 Feb;23(1):3-11
references.pmid: 23465882
references.citation: Nucleic Acids Res. 2009 Jan;37(1):1-13
references.pmid: 19033363
references.citation: Nat Genet. 2013 Oct;45(10):1113-20
references.pmid: 24071849
references.citation: Sci Am. 2007 Mar;296(3):50-7
references.pmid: 17348159
references.citation: BMC Genomics. 2006 Feb 15;7:25
references.pmid: 16480513
references.citation: Evol Dev. 2009 Jan-Feb;11(1):50-68
references.pmid: 19196333
references.citation: Nature. 2006 Apr 6;440(7085):757-63
references.pmid: 16598249
references.citation: Am J Psychol. 1987 Fall-Winter;100(3-4):441-71
references.pmid: 3322052
references.citation: Annu Rev Pathol. 2009;4:199-227
references.pmid: 18817506
references.citation: Nature. 2013 Oct 17;502(7471):333-339
references.pmid: 24132290
references.citation: RNA Biol. 2011 Sep-Oct;8(5):706-13
references.pmid: 21712654