title: [Evaluation of haemostasis and endothelial dysfunction characteristics in patient with community-acquired pneumonia].
abstract: The article deals with a study of hemostasis (D-dimer soluble fibrin-monomer complex, time fibrin self-assemblance, antitrombin III, fibrinogen), endothelial dysfunction (f. Willebrand and activity of plasminogen activators inhibitor type 1) and CRP in 61 patients with CAP in the day of admission and before discharge from hospital 17 patients had a severe pneumonia, 6 people died. The levels of all markers (except AT-3) were increased on admission and were reduced before discharge, but within the normal range to include only FW, CRP and time fibrin self-assemblance. DD, CRP and PAI-1 were dependent on the severity of the CAP, severity of SIRS and extent of the inflammatory process. The risk of severe pneumonia increased with the level of D-dimer in the onset of the disease more than 2.0 mkg mL(-1) (OR = 21.8, 95% CI: 3.09-154.8), with the results of TP-test less than 0.5 (RR = 2.68, 95% CI: 1.23-5.84), with CRP greater than 200 mg l(-1) (OR = 4.6, 95% CI: 1.87-11.45) and PAI-1 activity more than 30 U l(-1) (OR = 2.05, 95% CI: 0.88-4.74). Rg-CAP outcomes best reflect the level of DD, measured prior to discharge patients.
authors.forename: N V
authors.initials: NV
authors.lastname: Bedilo
authors.forename: N A
authors.initials: NA
authors.lastname: Vorob'eva
authors.forename: N V
authors.initials: NV
authors.lastname: Ismaĭlova
authors.forename: N A
authors.initials: NA
authors.lastname: Veshchagina
authors.forename: I Ia
authors.initials: IIa
authors.lastname: Nasonov
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Malugin
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D017714:Community-Acquired Infections; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D018410:Pneumonia, Bacterial / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D011237:Predictive Value of Tests; D012720:Severity of Illness Index
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D002097:C-Reactive Protein