title: Comparing efficacy of three methods of tranexamic acid administration in reducing hemoglobin drop following total knee arthroplasty.
abstract: The ideal method of providing tranexamic acid (TXA) for decreasing hemoglobin drop after TKA is still controversial. In this clinical trial, 200 patients were randomly allocated to four groups. In group 1,500 mg TXA was administered intravenously. In group 2, the joint irrigated with 3 g of TXA in 100 cc of saline. In group 3, 1.5 g of TXA was injected through the drain. Group 4 did not take TXA. Albeit all methods had a statistical effect on hemoglobin drop, drainage and number of transfused units when compared to controls, but intravenous injection of TXA seems to be much more effective in terms of reducing hemoglobin drop and transfused units; and what's more TXA injection by drain is more effective regarding to reducing postoperative drainage.
authors.affiliation: Department of Orthopedics, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Sarzaeem
authors.affiliation: Department of Orthopedics, Hazrat-e-Roasul Akram Medical Center, Iran University of Medical Science, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Razi
authors.affiliation: Department of Orthopedics, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Gholamhosein
authors.initials: G
authors.lastname: Kazemian
authors.affiliation: Department of Orthopedics, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Emami
authors.initials: ME
authors.lastname: Moghaddam
authors.affiliation: Department of Orthopedics, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza Manafi
authors.initials: AM
authors.lastname: Rasi
authors.affiliation: Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
authors.forename: Meysam
authors.initials: M
authors.lastname: Karimi
mesh_terms: D000368:Aged; D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion; D004322:Drainage / Q000379:methods; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007270:Injections, Intra-Articular; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012965:Sodium Chloride / Q000008:administration & dosage; D014148:Tranexamic Acid / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000933:Antifibrinolytic Agents; D006454:Hemoglobins; D012965:Sodium Chloride; D014148:Tranexamic Acid
keywords: hemoglobin drop; intra-articular injection; intravenous injection; total knee arthroplasty; tranexamic acid