title: Free-fatty-acid-regulating effects of fermented red ginseng are mediated by hormones and by the autonomic nervous system.
abstract: BACKGROUND
  Understanding what causes changes in the flux of free fatty acids (FFA) is important to elucidate the etiology of metabolic syndrome. The first aim of this study was to test whether or not hormones and the autonomic nervous system influence blood FFA levels. A secondary aim was to test by means of a multiple group path analysis whether the consumption of fermented red ginseng (FRG; Panax ginseng) would influence those causal relationships.
  
  
  METHODS
  Ninety-three postmenopausal women (age 50-73 yr) were randomly divided into two groups. One group (44 women; age, 58.4 ± 5.9 yr; body mass index, 23.6 ± 2.5 kg/m(2)) was supplied placebo capsules and the other group (49 women, age 58.4 ± 5.5 yr; body mass index, 22.9 ± 2.4 kg/m(2)) was supplied FRG capsules. Both prior to and after the study (2 wk), blood samples were collected from the participants and several blood variables were measured and analyzed.
  
  
  RESULTS
  Squared multiple correlations of FFA were 0.699 in the placebo group and 0.707 in the FRG group. The unstandardized estimate of estradiol (E2) for FFA was 0.824 in both groups.
  
  
  CONCLUSIONS
  The path coefficients of cortisol and the branchial pulse for FFA were significantly different between the FRG group and the placebo group.
authors.affiliation: Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, Korea.
authors.forename: Kwang Jo
authors.initials: KJ
authors.lastname: Lee
authors.affiliation: Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, Korea ; Research Center, BIFIDO Co. Ltd, Kangwon, Korea.
authors.forename: Geun Eog
authors.initials: GE
authors.lastname: Ji
keywords: Panax ginseng; autonomic nervous system; cortisol; estradiol; free fatty acid
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