title: Increased dynamin-1 and -2 protein expression in the aged gerbil hippocampus.
abstract: Dynamin (DNM) plays roles in membrane dynamics, vesicle formation, and transport. In the present study, we compared DNM-1 and DNM-2 protein expressions between the adult (postnatal month 6) and aged (postnatal month 24) gerbil hippocampus using immunohistochemistry and western blot analysis. DNM-1 and DNM-2 immunoreactivities were primarily observed in hippocampal principal neurons: pyramidal cells in the hippocampus proper (CA1-CA3) and granule cells in the dentate gyrus. DNM-1 and DNM-2 immunoreactivities in principal neurons were significantly increased in the aged group compared with the adult group. In addition, DNM-1 and DNM-2 protein levels as well as phospho-DNM-1 level were significantly increased in the aged group. These results indicate that the increases of DNM-1 and DNM-2 protein expressions may reflect the age-related changes in hippocampal function.
authors.affiliation: Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, 330-714, South Korea.
authors.forename: Choong Hyun
authors.initials: CH
authors.lastname: Lee
authors.forename: Moo-Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D018891:Dentate Gyrus / Q000378:metabolism; D034284:Dynamin I / Q000378:metabolism*; D034285:Dynamin II / Q000378:metabolism*; D005849:Gerbillinae / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism*; D017966:Pyramidal Cells / Q000378:metabolism
chemical_list: D034284:Dynamin I; D034285:Dynamin II
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