title: Magnetic resonance support vector machine discriminates essential tremor with rest tremor from tremor-dominant Parkinson disease.
abstract: BACKGROUND
  The aim of the current study was to distinguish patients who had tremor-dominant Parkinson's disease (tPD) from those who had essential tremor with rest tremor (rET).
  
  
  METHODS
  We combined voxel-based morphometry-derived gray matter and white matter volumes and diffusion tensor imaging-derived mean diffusivity and fractional anisotropy in a support vector machine (SVM) to evaluate 15 patients with rET and 15 patients with tPD. Dopamine transporter single-photon emission computed tomography imaging was used as ground truth.
  
  
  RESULTS
  SVM classification of individual patients showed that no single predictor was able to fully discriminate patients with tPD from those with rET. By contrast, when all predictors were combined in a multi-modal algorithm, SVM distinguished patients with rET from those with tPD with an accuracy of 100%.
  
  
  CONCLUSIONS
  SVM is an operator-independent and automatic technique that may help distinguish patients with tPD from those with rET at the individual level.
authors.affiliation: Neuroimaging Research Unit, Institute of Molecular Bioimaging and Physiology-National Research Council, Catanzaro, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Cherubini
authors.forename: Rita
authors.initials: R
authors.lastname: Nisticó
authors.forename: Fabiana
authors.initials: F
authors.lastname: Novellino
authors.forename: Maria
authors.initials: M
authors.lastname: Salsone
authors.forename: Salvatore
authors.initials: S
authors.lastname: Nigro
authors.forename: Giulia
authors.initials: G
authors.lastname: Donzuso
authors.forename: Aldo
authors.initials: A
authors.lastname: Quattrone
mesh_terms: D000368:Aged; D000465:Algorithms; D056324:Diffusion Tensor Imaging; D020329:Essential Tremor / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000000981:diagnostic imaging; D018709:Statistics, Nonparametric; D060388:Support Vector Machine; D015899:Tomography, Emission-Computed, Single-Photon; D014202:Tremor / Q000175:diagnosis* / Q000209:etiology*
keywords: computer-aided diagnosis; magnetic resonance imaging; resting tremor; support vector machine