title: Association between 17q12-21 variants and asthma in Japanese women: rs11650680 polymorphism as potential genetic marker for asthma.
abstract: Epidemiological evidence on the relationship between single-nucleotide polymorphisms (SNPs) rs7216389 and rs11650680 on chromosome 17q12-21 and asthma is inconsistent. We examined this issue in young adult Japanese women. Case subjects were 202 women who had been diagnosed with asthma by a doctor, while 1290 women without doctor-diagnosed asthma served as control subjects. Adjustments were made for age and the presence of older siblings. There were no significant associations between SNP rs7216389 and asthma. Compared with the CC genotype of SNP rs11650680, the CT genotype, but not the TT genotype, was significantly inversely associated with asthma: the adjusted odds ratio for the CT genotype was 0.67 (95% confidence interval: 0.46-0.96). This inverse relationship was significant in women with late-onset asthma, but not in those with early-onset asthma. Under the dominant model, a significant inverse association was found between rs11650680 and asthma in women without older siblings, but not in those with older siblings; the interaction, however, was not significant. This is the first study to show that the CT genotype of SNP rs11650680 was significantly inversely associated with asthma, especially adult-onset asthma. We could not find evidence for interactions between rs11650680 and older siblings affecting asthma.
authors.affiliation: 1 Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University , Fukuoka, Japan .
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyake
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Masashi
authors.initials: M
authors.lastname: Arakawa
mesh_terms: D000328:Adult; D001249:Asthma / Q000235:genetics*; D016022:Case-Control Studies; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007564:Japan; D020641:Polymorphism, Single Nucleotide
chemical_list: D005819:Genetic Markers
references.citation: J Allergy Clin Immunol. 2008 Apr;121(4):860-3
references.pmid: 18395550
references.citation: Genet Mol Res. 2012 Dec 19;11(4):4646-53
references.pmid: 23096927
references.citation: Eur Respir J. 2010 Jul;36(1):57-64
references.pmid: 20032010
references.citation: Ann Allergy Asthma Immunol. 2012 Jun;108(6):402-411.e9
references.pmid: 22626592
references.citation: Am J Respir Crit Care Med. 2009 Feb 1;179(3):179-85
references.pmid: 19029000
references.citation: J Allergy Clin Immunol. 2011 Jun;127(6):1587-94.e6
references.pmid: 21546069
references.citation: J Psychiatr Res. 2013 May;47(5):572-8
references.pmid: 23391129
references.citation: Genet Mol Res. 2012 Feb 10;11(1):340-7
references.pmid: 22370936
references.citation: Am J Respir Crit Care Med. 2008 Jun 1;177(11):1194-200
references.pmid: 18310477
references.citation: BMC Med Genet. 2011 Oct 11;12:133
references.pmid: 21985515
references.citation: Stat Med. 2002 Jan 15;21(1):35-50
references.pmid: 11782049
references.citation: Allergy. 2009 Apr;64(4):621-8
references.pmid: 19175592
references.citation: Pediatr Pulmonol. 2011 Jul;46(7):701-8
references.pmid: 21337730
references.citation: J Allergy Clin Immunol. 2008 Mar;121(3):769-70
references.pmid: 18155279
references.citation: Pharmacogenet Genomics. 2012 Jul;22(7):517-24
references.pmid: 22472724
references.citation: J Allergy Clin Immunol. 2008 Dec;122(6):1225-7
references.pmid: 18760456
references.citation: Eur J Hum Genet. 2010 Aug;18(8):902-8
references.pmid: 20372189
references.citation: N Engl J Med. 2013 Apr 11;368(15):1398-407
references.pmid: 23534543
references.citation: J Hum Genet. 2011 Jan;56(1):97-8
references.pmid: 20981039
references.citation: Nature. 2007 Jul 26;448(7152):470-3
references.pmid: 17611496
references.citation: Hum Immunol. 2012 Sep;73(9):954-9
references.pmid: 22732088
references.citation: Bioinformatics. 2005 Jan 15;21(2):263-5
references.pmid: 15297300