title: New fatty acids from the Red Sea sponge Mycale euplectellioides.
abstract: Chemical investigation of the Red Sea sponge Mycale euplectellioides afforded two new compounds; hexacosa-(6Z,10Z)-dienoic acid methyl ester (1) and hexacosa-(6Z,10Z)-dienoic acid (2), along with two known compounds: icosa-(8Z,11Z)-dienoic acid methyl ester (3) and β-sitosterol (4). The structures were elucidated by the interpretation of their spectral data. The total methanol extract (TME) of the sponge exhibited potent antimicrobial activity against the different strains at a concentration of 100 mg/mL. All tested fractions did not exhibit any activity against Serratia marcescens and tested fungal strains. The TME and different fractions displayed anti-inflammatory and antipyretic activities at doses of 100 and 200 mg/kg compared with indomethacin (8 mg). The TME exhibited a remarkable hepato-protective effect in CCl4-induced liver damage compared with silymarin. Furthermore, compounds 1 and 2 displayed weak activity against A549 non-small cell lung cancer, the U373 glioblastoma and the PC-3 prostate cancer cell lines.
authors.affiliation: a Department of Natural Products , Faculty of Pharmacy, King Abdulaziz University , Jeddah 21589 , Saudi Arabia.
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Mohamed
authors.forename: Ali E E
authors.initials: AE
authors.lastname: Abd-Elrazek
authors.forename: Hashim A
authors.initials: HA
authors.lastname: Hassanean
authors.forename: Abdulrahman M
authors.initials: AM
authors.lastname: Alahdal
authors.forename: Ameen
authors.initials: A
authors.lastname: Almohammadi
authors.forename: Diaa T A
authors.initials: DT
authors.lastname: Youssef
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001231:Aspergillus flavus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects; D005848:Geotrichum / Q000187:drug effects; D006801:Humans; D019156:Indian Ocean; D008099:Liver / Q000187:drug effects; D008297:Male; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D012855:Sitosterols / Q000302:isolation & purification; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D005231:Fatty Acids, Unsaturated; D012855:Sitosterols; C000592821:hexacosa-(6Z,10Z)-dienoic acid; C000592820:hexacosa-(6Z,10Z)-dienoic acid methyl ester; C025473:gamma-sitosterol
keywords: Mycale euplectellioides; Red Sea sponge; anti-inflammatory; cancer growth inhibitory activity; fatty acids; hepato-protective