title: Population-based study of esophageal and small intestinal atresia/stenosis.
abstract: BACKGROUND
  The aim of this study was to describe the prevalence of esophageal atresia/stenosis and small intestinal atresia/stenosis in Nagano, Japan, together with associated anomalies, prenatal diagnosis and survival.
  
  
  METHODS
  A population-based cohort study of the prevalence of esophageal atresia/stenosis and small intestinal atresia/stenosis was conducted in Nagano in January 1993-December 2011. The Mann-Whitney test, χ(2) test and Kruskal-Wallis test were used to compare variables. P < 0.05 was considered statistically significant.
  
  
  RESULTS
  In total, 74 cases of esophageal atresia/stenosis and 87 cases of small intestinal atresia/stenosis (31 duodenal, 56 jejuno-ileal) were identified. Prevalences were 1.97 for esophageal atresia/stenosis and 2.23 for small intestinal atresia/stenosis (0.83 for duodenal atresia/stenosis and 1.49 for jejuno-ileal atresia/stenosis) per 10,000 births, respectively. The prevalence of esophageal atresia/stenosis increased significantly from 1993-2001 to 2002-2011 (relative risk [RR], 1.6), as did the prevalences of duodenal atresia/stenosis (RR, 2.2) and jejuno-ileal atresia/stenosis (RR, 3.1). Chromosomal anomalies, particularly trisomy 21, were seen significantly more often in association with duodenal atresia/stenosis (55%) than with esophageal atresia/stenosis (28%, P < 0.01) or jejuno-ileal atresia/stenosis (2%, P < 0.01). The proportion of patients associated with prenatally diagnosed chromosomal anomaly was higher compared to postnatal diagnosis (P < 0.01) in the esophageal atresia/stenosis group.
  
  
  CONCLUSIONS
  The prevalence of esophageal and small intestinal atresia/stenosis increased significantly from 1993-2001 to 2002-2011. Prenatally diagnosed esophageal atresia/stenosis is associated with multiple anomalies, particularly chromosomal anomalies, compared to other small intestine atresia/stenosis.
authors.affiliation: Division of Neonatology, Nagano Children's Hospital, Nagano, Japan.|Division of Pediatrics, Fukuda Hospital, Kumamoto, Japan.
authors.forename: Daijiro
authors.initials: D
authors.lastname: Takahashi
authors.affiliation: Division of Neonatology, Nagano Children's Hospital, Nagano, Japan.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Hiroma
authors.affiliation: Department of Surgery, Nagano Children's Hospital, Nagano, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Takamizawa
authors.affiliation: Division of Neonatology, Nagano Children's Hospital, Nagano, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D015331:Cohort Studies; D004933:Esophageal Atresia / Q000175:diagnosis / Q000453:epidemiology*; D004940:Esophageal Stenosis / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007409:Intestinal Atresia / Q000175:diagnosis / Q000453:epidemiology*; D007421:Intestine, Small / Q000002:abnormalities*; D007564:Japan / Q000453:epidemiology; D008297:Male; D015995:Prevalence
keywords: esophageal atresia/stenosis; population-based study; small intestinal atresia/stenosis