title: Partial volume corrected 18F-FDG PET mean standardized uptake value correlates with prognostic factors in breast cancer.
abstract: OBJECTIVE
  The aim of this paper was to assess the prognostic role of pretherapy partial volume corrected (PVC) 18F-fluorodeoxyglucose mean standardized uptake value (SUV) in breast cancer (BC).
  
  
  METHODS
  Forty oncological patients, BC diagnosed by biopsy, with breast tumor mass diameter >1 cm measured to the mammography, designed for surgical intervention, underwent a pretherapy semi-quantitative 18F-FDG positron emission tomography/computed tomography (18F-FDG PET/CT) whole-body study for tumor staging. Mean Body-Weight Standardized Uptake Value with Correction for Partial Volume effect (PVC- SUVBW-mean) was calculated in all mammary detected lesions. Excised tissues from primitive BC were sectioned and classified according to the WHO guidelines, evaluating biological features. Univariate (Mann-Withney/Kruskal-Wallis) and multivariate (linear regression, hierarchical clustering) statistical tests were performed between PVC-SUVBW-mean and biological indexes. ROC analysis was performed. PVC-SUVBW-mean thresholds were derived allowing to distinguish groups of BC patients with different biological characteristics. Specificity and Sensitivity were also calculated.
  
  
  RESULTS
  Statistical and multiple correlations between pretherapy 18F-FDG PET PVC-SUVBW-mean and histological type, grade, ER/PgR hormone receptors and Mib-1 cellular proliferation index were found. In our samples, PVC-SUVBW-mean <≈4 g/cc was found correlated to BC patients with Invasive Lobular Carcinoma (ILC) or well differentiated Invasive Ductal Carcinoma (IDC), a positive expression of ER and PgR and a negative expression of MiB-1, while PVC-SUVBW-mean >≈7.00 is associated to BC patients with moderately and poorly differentiated IDC, negative expression of ER and PgR and a positive expression of MiB-1.
  
  
  CONCLUSIONS
  Pretherapy PVC 18F-FDG PET PVC-SUVBW-mean measurement correlates with prognostic factors in BC and could be used to stratify patients before intervention.
authors.affiliation: IBFM-CNR, Segrate, Milan, Italy - isabella.castiglioni@ibfm.cnr.it.
authors.forename: F
authors.initials: F
authors.lastname: Gallivanone
authors.forename: C
authors.initials: C
authors.lastname: Canevari
authors.forename: I
authors.initials: I
authors.lastname: Sassi
authors.forename: V
authors.initials: V
authors.lastname: Zuber
authors.forename: A
authors.initials: A
authors.lastname: Marassi
authors.forename: L
authors.initials: L
authors.lastname: Gianolli
authors.forename: M
authors.initials: M
authors.lastname: Picchio
authors.forename: C
authors.initials: C
authors.lastname: Messa
authors.forename: M C
authors.initials: MC
authors.lastname: Gilardi
authors.forename: I
authors.initials: I
authors.lastname: Castiglioni
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001835:Body Weight; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D016000:Cluster Analysis; D003627:Data Interpretation, Statistical; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008327:Mammography / Q000379:methods; D008875:Middle Aged; D015233:Models, Statistical; D064847:Multimodal Imaging; D015999:Multivariate Analysis; D049268:Positron-Emission Tomography / Q000379:methods*; D011379:Prognosis; D012372:ROC Curve; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D019788:Fluorodeoxyglucose F18