title: Force measurement tools to explore cadherin mechanotransduction.
abstract: Cell-cell adhesions serve to mechanically couple cells, allowing for long-range transmission of forces across cells in development, disease, and homeostasis. Recent work has shown that such contacts also play a role in transducing mechanical cues into a wide variety of cellular behaviors important to tissue function. As such, understanding the mechanical regulation of cells through their adhesion molecules has become a point of intense focus. This review will highlight the existing and emerging technologies and models that allow for exploration of cadherin-based adhesions as sites of mechanotransduction.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Pennsylvania , Philadelphia, PA , USA.
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Stapleton
authors.forename: Anant
authors.initials: A
authors.lastname: Chopra
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Chen
mesh_terms: D015820:Cadherins / Q000378:metabolism*; D002448:Cell Adhesion; D006801:Humans; D040542:Mechanotransduction, Cellular
chemical_list: D015820:Cadherins
keywords: adherens junctions; cadherins; cell adhesions; force transduction; mechanotransduction; traction force microscopy
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