title: Aminative umpolung synthesis of aryl vicinal diamines from aromatic aldehydes.
abstract: In this paper an aminative umpolung synthesis of aryl vicinal diamines from aldehydes and N-Ts imines is described. Electrophilic aromatic aldehydes were smoothly converted into delocalized 2-azaallylanions via condensation with 2,2-diphenylglycine in methanol and subsequent decarboxylation in THF and underwent further reaction with N-Ts imines to give a variety of 1,2-diamine derivatives in good yields with high syn/anti diastereoselectivity.
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University , Shanghai 200234, P. R. China.
authors.forename: Xuliang
authors.initials: X
authors.lastname: Liu
authors.forename: Ang
authors.initials: A
authors.lastname: Gao
authors.forename: Lei
authors.initials: L
authors.lastname: Ding
authors.forename: Juan
authors.initials: J
authors.lastname: Xu
authors.forename: Baoguo
authors.initials: B
authors.lastname: Zhao
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D003959:Diamines; D007097:Imines