title: Biodegradable and thermosensitive monomethoxy poly(ethylene glycol)-poly(lactic acid) hydrogel as a barrier for prevention of post-operative abdominal adhesion.
abstract: Post-operative peritoneal adhesions are serious consequences of abdominal or pelvic surgery and cause severe bowel obstruction, chronic pelvic pain and infertility. In this study, a novel nano-hydrogel system based on a monomethoxy poly(ethylene glycol)-poly(lactic acid) (MPEG-PLA) di-block copolymer was studied for its ability to prevent abdominal adhesion in rats. The MPEG-PLA hydrogel at a concentration of 40% (w/v) was injected and was able to adhere to defect sites at body temperature. The ability of the hydrogel to inhibit adhesion of post-operative tissues was evaluated by utilizing a rat model of abdominal sidewall-cecum abrasion. It was possible to heal wounded tissue through regeneration of neo-peritoneal tissues ten days after surgery. Our data showed that this hydrogel system is equally as effective as current commercialized anti-adhesive products.
authors.forename: Shao Zhi
authors.initials: SZ
authors.lastname: Fu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.forename: Jun Ming
authors.initials: JM
authors.lastname: Fan
authors.forename: Xiao Hang
authors.initials: XH
authors.lastname: Meng
authors.forename: Kun
authors.initials: K
authors.lastname: Shi
authors.forename: Ying
authors.initials: Y
authors.lastname: Qu
authors.forename: Ling Lin
authors.initials: LL
authors.lastname: Yang
authors.forename: Jing Bo
authors.initials: JB
authors.lastname: Wu
authors.forename: Juan
authors.initials: J
authors.lastname: Fan
authors.forename: Feng
authors.initials: F
authors.lastname: Luot
authors.forename: Zhi Yong
authors.initials: ZY
authors.lastname: Qian
mesh_terms: D000005:Abdomen / Q000601:surgery*; D058107:Abdominal Wound Closure Techniques / Q000009:adverse effects; D020341:Absorbable Implants; D000818:Animals; D002429:Cecal Diseases / Q000517:prevention & control; D002432:Cecum; D004353:Drug Evaluation, Preclinical; D005260:Female; D020100:Hydrogels / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010532:Peritoneal Diseases / Q000517:prevention & control; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D013696:Temperature; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D020100:Hydrogels; C542623:monomethoxypolyethyleneglycol-polylactide block copolymer; D011092:Polyethylene Glycols