title: G protein-coupled receptor 56 regulates matrix production and motility of lung fibroblasts.
abstract: Idiopathic pulmonary fibrosis is a chronic, progressive, and fatal fibrotic lung disease with a poor prognosis, but no effective treatment is available. G protein-coupled receptor 56 (GPR56) plays a role in cell adhesion and tumor progression, but its function in fibrogenesis has not been explored. In this in vitro study, we found that GPR56 in IPF fibroblasts was lower than in normal fibroblasts. GPR56 regulated the production of fibronectin and type I collagen, and also changed the migratory and invasive capacity of lung fibroblasts. However, it was not sufficient to activate some classic markers of fibroblast and myofibroblast, such as α-smooth muscle actin and fibroblast specific protein 1. These findings demonstrate that reduced expression of GPR56 in lung fibroblasts may be an important link with pulmonary fibrosis, playing a role in regulating some important fibroblast functions.
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Zhanyong
authors.initials: Z
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Leng
authors.forename: Huaping
authors.initials: H
authors.lastname: Dai
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Jiurong
authors.initials: J
authors.lastname: Liang
authors.forename: Dianhua
authors.initials: D
authors.lastname: Jiang
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
mesh_terms: D000199:Actins / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002465:Cell Movement; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000378:metabolism* / Q000473:pathology; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D043562:Receptors, G-Protein-Coupled / Q000096:biosynthesis*; D000071999:S100 Calcium-Binding Protein A4
chemical_list: C118925:ADGRG1 protein, human; D000199:Actins; D002135:Calcium-Binding Proteins; D043562:Receptors, G-Protein-Coupled; D000071999:S100 Calcium-Binding Protein A4; C077591:S100A4 protein, human