title: Volitional modulation of optically recorded calcium signals during neuroprosthetic learning.
abstract: Brain-machine interfaces are not only promising for neurological applications, but also powerful for investigating neuronal ensemble dynamics during learning. We trained mice to operantly control an auditory cursor using spike-related calcium signals recorded with two-photon imaging in motor and somatosensory cortex. Mice rapidly learned to modulate activity in layer 2/3 neurons, evident both across and within sessions. Learning was accompanied by modifications of firing correlations in spatially localized networks at fine scales.
authors.affiliation: Biophysics Program, UC Berkeley, University of California, Berkeley.
authors.forename: Kelly B
authors.initials: KB
authors.lastname: Clancy
authors.affiliation: Helen Wills Neuroscience Institute, UC Berkeley, University of California, Berkeley.
authors.forename: Aaron C
authors.initials: AC
authors.lastname: Koralek
authors.affiliation: Champalimaud Neuroscience Programme Champalimaud Center for the Unknown, Lisbon, Portugal.
authors.forename: Rui M
authors.initials: RM
authors.lastname: Costa
authors.affiliation: Helen Wills Neuroscience Institute, UC Berkeley, University of California, Berkeley.|Dept. of Molecular & Cell Biology, UC Berkeley, University of California, Berkeley.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Feldman
authors.affiliation: Helen Wills Neuroscience Institute, UC Berkeley, University of California, Berkeley.|Department of Electrical Engineering and Computer Sciences, University of California, Berkeley.|Joint Graduate Group in Bioengineering UCB/UCSF, University of California, Berkeley.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Carmena
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D062207:Brain-Computer Interfaces; D020013:Calcium Signaling / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D007858:Learning / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D036641:Microscopy, Fluorescence, Multiphoton / Q000379:methods; D014836:Volition / Q000502:physiology*
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