title: Delayed onset of rotatory self-motion perception, dysdiadochokinesia and disturbed eye pursuit caused by low-dose pregabalin.
abstract: A 30-year-old woman with chronic foot pain after an orthopaedic surgery and chronic neck pain presented to the emergency department (ED) with a history of self-rotatory vertigo with unsteadiness. She had started low-dose pregabalin, 25 mg two times a day 9 months before experiencing symptoms with the dose gradually increased to 150 mg two times a day over this period. Clinical examination revealed difficulty performing eye pursuit with left eye and dysdiadochokinesia of the left arm. Owing to a suspicion of multiple sclerosis she underwent cerebral MRI, which was normal. Pregabalin was tapered over 2 months with a complete disappearance of the symptoms. We concluded that symptoms were due to pregabalin treatment.
authors.affiliation: Hôpital du Jura Bernois, Saint-Imier, Switzerland.
authors.forename: Patrice
authors.initials: P
authors.lastname: Hounnou
authors.forename: Keyvan
authors.initials: K
authors.lastname: Nicoucar
mesh_terms: D000328:Adult; D000700:Analgesics / Q000009:adverse effects*; D002524:Cerebellar Ataxia / Q000139:chemically induced*; D059350:Chronic Pain / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015835:Ocular Motility Disorders / Q000139:chemically induced*; D000069583:Pregabalin; D014717:Vertigo / Q000139:chemically induced*; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000700:Analgesics; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid
references.citation: Am J Psychiatry. 2010 Jul;167(7):869
references.pmid: 20595436
references.citation: Clin Ther. 2007 Jan;29(1):26-48
references.pmid: 17379045
references.citation: Eur J Neurol. 2010 Aug;17(8):1082-9
references.pmid: 20236172
references.citation: Epilepsy Behav. 2007 Nov;11(3):471-3
references.pmid: 17900992
references.citation: Epilepsy Behav. 2008 Aug;13(2):418-20
references.pmid: 18492617
references.citation: Epilepsia. 2011 Apr;52(4):826-36
references.pmid: 21320112
references.citation: BMJ Case Rep. 2012 Nov 28;2012:
references.pmid: 23192584