title: Killer cell immunoglobulin-like receptors in Thai patients with leukemia and diffuse large B-cell lymphoma.
abstract: Natural killer (NK) cells are key components of the innate immune system that have been implicated in the immune response against tumor cells. Killer cell immunoglobulin-like receptors (KIR) regulate NK cell activity by interaction with specific human leukocyte antigen (HLA) class I. In this study, KIR gene polymorphisms and their HLA ligands were investigated in Thai patients with chronic myelogenous leukemia (CML) (n=60), acute myelogenous leukemia (AML) (n=60), acute lymphoblastic leukemia (ALL) (n=55), and diffuse large B-cell lymphoma (DLBCL) (n=60) compared with 150 healthy controls. The frequency of KIR3DL1 with HLA-Bw4 was significantly lower in DLBCL patients than in controls (P=0.0006, Pc=0.02), whereas no significant differences were seen in KIR gene frequencies and their ligands between leukemia patients and controls. This study suggest a role of inhibitory KIR with its ligand in the protection against DLBCL.
authors.affiliation: Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand. Electronic address: sasijit.vej@mahidol.ac.th.
authors.forename: Sasijit
authors.initials: S
authors.lastname: Vejbaesya
authors.affiliation: Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand.
authors.forename: Pradermchai
authors.initials: P
authors.lastname: Sae-Tam
authors.affiliation: Department of Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
authors.forename: Archrob
authors.initials: A
authors.lastname: Khuhapinant
authors.affiliation: Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand.
authors.forename: Duangporn
authors.initials: D
authors.lastname: Srinak
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D002648:Child; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000208:ethnology / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000208:ethnology / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008024:Ligands; D016403:Lymphoma, Large B-Cell, Diffuse / Q000208:ethnology / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000208:ethnology / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D054341:Receptors, KIR3DL1 / Q000235:genetics* / Q000276:immunology; D013785:Thailand
chemical_list: D015235:HLA-B Antigens; C042388:HLA-Bw4 antigen; C515083:KIR3DL1 protein, human; D008024:Ligands; D054341:Receptors, KIR3DL1
keywords: DLBCL; KIR; Leukemia; Thai