title: Lipid droplet biogenesis.
abstract: Lipid droplets (LDs) are found in most cells, where they play central roles in energy and membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly understood process involving the formation of a monolayer bound organelle from a bilayer membrane. Additionally, large LDs can form either by growth of existing LDs or by the combination of smaller LDs through several distinct mechanisms. Here, we review recent insights into the molecular process governing LD biogenesis and highlight areas of incomplete knowledge.
authors.affiliation: Yale School of Medicine, Department of Cell Biology, New Haven, CT, USA.
authors.forename: Florian
authors.initials: F
authors.lastname: Wilfling
authors.affiliation: Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California-San Francisco, CA, USA.
authors.forename: Joel T
authors.initials: JT
authors.lastname: Haas
authors.affiliation: Yale School of Medicine, Department of Cell Biology, New Haven, CT, USA. Electronic address: tobias.walther@yale.edu.
authors.forename: Tobias C
authors.initials: TC
authors.lastname: Walther
authors.affiliation: Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California-San Francisco, CA, USA; Department of Medicine, University of California-San Francisco, CA, USA. Electronic address: bfarese@gladstone.ucsf.edu.
authors.forename: Robert V
authors.initials: RV
authors.lastname: Farese
mesh_terms: D000818:Animals; D001692:Biological Transport; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D015388:Organelles / Q000378:metabolism; D022161:Transport Vesicles / Q000378:metabolism*
chemical_list: D008055:Lipids
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