title: Universal area distributions in the monolayers of confluent mammalian cells.
abstract: When mammalian cells form confluent monolayers completely filling a plane, these apparently random "tilings" show regularity in the statistics of cell areas for various types of epithelial and endothelial cells. The observed distributions are reproduced by a model which accounts for cell growth and division, with the latter treated stochastically both in terms of the sizes of the dividing cells as well as the sizes of the "newborn" ones--remarkably, the modeled and experimental distributions fit well when all free parameters are estimated directly from experiments.
authors.affiliation: Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Wilk
authors.affiliation: Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
authors.forename: Masatomo
authors.initials: M
authors.lastname: Iwasa
authors.affiliation: Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
authors.forename: Patrick E
authors.initials: PE
authors.lastname: Fuller
authors.affiliation: Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
authors.forename: Kristiana
authors.initials: K
authors.lastname: Kandere-Grzybowska
authors.affiliation: Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA and Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
authors.forename: Bartosz A
authors.initials: BA
authors.lastname: Grzybowski
mesh_terms: D000818:Animals; D016466:CHO Cells; D002455:Cell Division / Q000502:physiology; D048708:Cell Growth Processes / Q000502:physiology; D002460:Cell Line; D003412:Cricetulus; D004285:Dogs; D042783:Endothelial Cells / Q000166:cytology*; D004847:Epithelial Cells / Q000166:cytology*; D006801:Humans; D061985:Madin Darby Canine Kidney Cells; D008954:Models, Biological; D013552:Swine
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