title: Genetic experimental preparations for studying atherosclerosis.
abstract: Atherosclerosis is a pathological process with several inputs (biological, chemical, physiological, and others) interacting slowly over a lifetime leading to coronary artery disease, significant morbidity, and a limited lifespan. Over the past two decades, biologists have used experimental preparations from cells, animals, and man to understand the biology of atherosclerosis. Much has been discovered but our use of the standard gene-targeted experimental preparations is now nearing its limit. Better preparations to answer the remaining questions in the field of atherosclerosis biology are needed.
authors.affiliation: Department of Cardiovascular Science, Medical School, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Sheila E
authors.initials: SE
authors.lastname: Francis
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency / Q000378:metabolism; D050197:Atherosclerosis / Q000235:genetics*; D004195:Disease Models, Animal; D018390:Gene Targeting; D006801:Humans; D008077:Lipoproteins, LDL / Q000172:deficiency / Q000378:metabolism; D057170:Translational Research, Biomedical
chemical_list: D001057:Apolipoproteins E; D008077:Lipoproteins, LDL
keywords: Atherosclerosis; Gene targeting; Mouse; Porcine; Zebrafish