title: Multiplying messages LRRK beneath Parkinson disease.
abstract: Parkinson Disease (PD) is a progressive neurodegenerative disorder with limited therapeutic options. In this issue of Cell, Martin et al. link PD protein leucine-rich repeat kinase 2 (LRRK2) to abnormalities of translational control, a pathogenic mechanism implicated in an increasing number of CNS neurodegenerative diseases, as well as in normal aging.
authors.affiliation: Department of Neurology, Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA.
authors.forename: William T
authors.initials: WT
authors.lastname: Dauer
authors.affiliation: Department of Neurology, Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, University of California, 695 Charles Young Drive South, Los Angeles, CA 90095, USA. Electronic address: mingfly@ucla.edu.
authors.forename: Ming
authors.initials: M
authors.lastname: Guo
mesh_terms: D000818:Animals; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D009474:Neurons / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012269:Ribosomal Proteins / Q000378:metabolism*
chemical_list: D012269:Ribosomal Proteins; C036004:ribosomal protein S15; C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases