title: Brain embolism secondary to cardiac myxoma in fifteen Chinese patients.
abstract: BACKGROUND
  Heart myxoma-related embolisms commonly involve the central nervous system, but data are lacking in Chinese patients.
  
  
  METHODS
  27 patients diagnosed with myxoma were reviewed retrospectively.
  
  
  RESULTS
  Among 27 patients, fourteen (51.9%) patients were women. Fifteen (55.6%) patients had brain embolisms. Rarely, patients were misdiagnosed with central nervous system vasculitis (n = 2), moyamoya disease (n = 1), and neuromyelitis optica (n = 1). We found positive associations between mRS (>3) and female gender (r = 0.873, P < 0.0001), infection (r = 0.722, P = 0.002), severe complications (r = 0.722, P = 0.002), systolic blood pressure (SBP) of <120 mmHg (r = 0.6, P = 0.018), WBC count of >10 × 10(9)/L (r = 0.722, P = 0.002), tumour size (r = 0.866, P < 0.0001), bilateral brain lesions (r = 0.60, P = 0.018), and total anterior circulation infarction (TACI) (r = 0.667, P = 0.007). The independent relationships among these factors and outcomes could not be confirmed (P > 0.05).
  
  
  CONCLUSIONS
  Neurologic manifestations in Chinese patients with cardiac myxoma-related stroke were complicated and multifarious. Female gender, infection, other severe complications, low SBP, tumour size, bilateral brain lesions, TACI, and high WBC counts could be associated with a poor prognosis.
authors.affiliation: Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Institute of Neuroscience and the Second Affiliated Hospital of GuangZhou Medical University, 250 Changgang East Road, Guangzhou, Guangdong 510260, China ; Department of Neurology, The Second Affiliated Hospital of GuangZhou Medical University, 250 Changgang East Road, Guangzhou, Guangdong 510260, China.
authors.forename: Youming
authors.initials: Y
authors.lastname: Long
authors.affiliation: Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Institute of Neuroscience and the Second Affiliated Hospital of GuangZhou Medical University, 250 Changgang East Road, Guangzhou, Guangdong 510260, China ; Department of Neurology, The Second Affiliated Hospital of GuangZhou Medical University, 250 Changgang East Road, Guangzhou, Guangdong 510260, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006338:Heart Neoplasms / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D020766:Intracranial Embolism / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000150:complications / Q000175:diagnosis*; D012189:Retrospective Studies; D012737:Sex Factors
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