title: CARd-3D: Carbon Distribution in 3D Structure Program for Globular Proteins.
abstract: Spatial arrangement of carbon in protein structure is analyzed here. Particularly, the carbon fractions around individual atoms are compared. It is hoped that it follows the principle of 31.45% carbon around individual atoms. The results reveal that globular protein's atoms follow this principle. A comparative study on monomer versus dimer reveal that carbon is better distributed in dimeric form than in its monomeric form. Similar study on solid versus liquid structures reveals that the liquid (NMR) structure has better carbon distribution over the corresponding solid (X-Ray) structure. The carbon fraction distributions in fiber and toxin protein are compared. Fiber proteins follow the principle of carbon fraction distribution. At the same time it has another broad spectrum of carbon distribution than in globular proteins. The toxin protein follows an abnormal carbon fraction distribution. The carbon fraction distribution plays an important role in deciding the structure and shape of proteins. It is hoped to help in understanding the protein folding and function.
authors.affiliation: Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Karunya Nagar, Coimbatore -641114, Tamil Nadu, India.
authors.forename: Rajasekaran
authors.initials: R
authors.lastname: Ekambaram
authors.affiliation: Department of Bioinformatics, Bishop Heber College, Trichy-620017, Tamil Nadu, India.
authors.forename: Akila
authors.initials: A
authors.lastname: Kannaiyan
authors.affiliation: Molecular Biophysics Unit, Indian Institute of Science, Bangalore - 560012, Karnataka, India.
authors.forename: Vijayasarathy
authors.initials: V
authors.lastname: Marimuthu
authors.affiliation: Department of Bioinformatics, Marudhu Pandiyar College, Vallam, Thanjavur - 613403, Tamil Nadu, India.
authors.forename: Vinobha Chinnaiah
authors.initials: VC
authors.lastname: Swaminathan
authors.affiliation: Department of Bioinformatics, Marudhu Pandiyar College, Vallam, Thanjavur - 613403, Tamil Nadu, India.
authors.forename: Senthil
authors.initials: S
authors.lastname: Renganathan
authors.affiliation: BioInformatics Research Centre, School of Computer Engineering, Nanyang Technological University, Block NS4-04-33, Singapore - 639798 Singapore.
authors.forename: Ananda Gopu
authors.initials: AG
authors.lastname: Perumal
keywords: CARd3D; carbon distribution; carbon fraction; crystal structure; hydrophobic scale; protein structure
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