title: Periapical tissue reaction to calcium phosphate root canal sealer in porcine model.
abstract: BACKGROUND
  Calcium phosphate cements (CPC) are a group of biomaterials possessing wide scope of use in various branches of medical science. These materials have been proposed to be highly biocompatible and osteoconductive. This study is based on a newly developed CPC formulation (Chitra-CPC) and is aimed at the evaluation of its biocompatibility through an Endodontic Usage Test in a porcine study model.
  
  
  OBJECTIVE
  To evaluate the periapical tissue reaction to Chitra-CPC when used as a root canal sealer/filler material in comparison with a resin sealer, AH Plus (Dentsply).
  
  
  METHODS
  The procedure was done on porcine animal model following the ISO 7405 criteria. The material was implanted intentionally into the periapical area of 36 teeth through a root canal procedure carried out in six animals which were divided equally among 1-month and 3-month time periods. Results were based on the histological evaluation of the autopsied specimens after the prescribed time periods.
  
  
  RESULTS
  Mild to moderate periapical tissue reaction was found in Chitra-CPC samples belonging to the 1-month time period, whereas majority of the 3-month CPC samples showed an absence of inflammation. Samples of AH Plus in 1-month period showed severe to moderate inflammation, whereas 3-month AH Plus samples had a mild to moderate inflammation.
  
  
  CONCLUSIONS
  Chitra-CPC is a biocompatible material.
authors.affiliation: Department of Conservative Dentistry and Endodontics, PSM College of Dental Science and Research, Akkikavu, Thrissur, Kerala, India.
authors.forename: George M
authors.initials: GM
authors.lastname: Jacob
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.forename: Jolly Mary
authors.initials: JM
authors.lastname: Varughese
authors.forename: N O
authors.initials: NO
authors.lastname: Varghese
authors.forename: P R Harikrishna
authors.initials: PR
authors.lastname: Varma
authors.forename: Manoj
authors.initials: M
authors.lastname: Komath
mesh_terms: D000818:Animals; D002130:Calcium Phosphates / Q000008:administration & dosage*; D002460:Cell Line; D023421:Models, Animal; D012387:Root Canal Filling Materials; D013552:Swine; D019227:Tooth Apex / Q000502:physiology*
chemical_list: D002130:Calcium Phosphates; D012387:Root Canal Filling Materials; C020243:calcium phosphate