title: Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived Streptomyces sp.
abstract: Three new acylated arylamine derivatives (1-3), carpatamides A-C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1-3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC50 values ranging from 2.2 to 8.4 μM.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas , Dallas, Texas 75390, United States.
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.forename: Melissa
authors.initials: M
authors.lastname: Johnson
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Posner
authors.forename: John B
authors.initials: JB
authors.lastname: MacMillan
mesh_terms: D000577:Amides; D000588:Amines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000577:Amides; D000588:Amines; D000970:Antineoplastic Agents; C000591940:carpatamide A; C000591941:carpatamide B; C000591942:carpatamide C
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