title: Strawberry extract presents antiplatelet activity by inhibition of inflammatory mediator of atherosclerosis (sP-selectin, sCD40L, RANTES, and IL-1β) and thrombus formation.
abstract: Cardiovascular disease prevention is of high priority in developed countries. Healthy eating habits including the regular intake of an antithrombotic diet (fruit and vegetables) may contribute to prevention. Platelet function is a critical factor in arterial thrombosis and the effect strawberries have is still unclear. Therefore, the aim of this study was to systematically examine the action of strawberries in preventing platelet activation and thrombus formation. Strawberry extract concentration-dependently (0.1-1 mg/ml) inhibited platelet aggregation induced by ADP and arachidonic acid. At the same concentrations as strawberry inhibits platelet aggregation, it significantly decreased sP-selectin, sCD40L, RANTES, and IL-1β levels. The strawberry may exert significant protective effects on thromboembolic-related disorders by inhibiting platelet aggregation. Also, this suggests that antithrombotic activity may have novel anti-inflammatory effects.
authors.affiliation: Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca , Talca , Chile .
authors.forename: Marcelo
authors.initials: M
authors.lastname: Alarcón
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fuentes
authors.forename: Natalia
authors.initials: N
authors.lastname: Olate
authors.forename: Simon
authors.initials: S
authors.lastname: Navarrete
authors.forename: Gilda
authors.initials: G
authors.lastname: Carrasco
authors.forename: Iván
authors.initials: I
authors.lastname: Palomo
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D023201:CD40 Ligand / Q000378:metabolism*; D018946:Chemokine CCL5 / Q000378:metabolism*; D004195:Disease Models, Animal; D031985:Fragaria / Q000737:chemistry*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D053583:Interleukin-1beta / Q000378:metabolism*; D051379:Mice; D019007:P-Selectin / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D015539:Platelet Activation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013927:Thrombosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D018946:Chemokine CCL5; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D019007:P-Selectin; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D023201:CD40 Ligand
keywords: Antiplatelet; IL-1β; P-selectin; RANTES; antithrombotic; sCD40L; strawberry