title: Quantitative 7T phase imaging in premanifest Huntington disease.
abstract: OBJECTIVE
  In vivo MR imaging and postmortem neuropathologic studies have demonstrated elevated iron concentration and atrophy within the striatum of patients with Huntington disease, implicating neuronal loss and iron accumulation in the pathogenesis of this neurodegenerative disorder. We used 7T MR imaging to determine whether quantitative phase, a measurement that reflects both iron content and tissue microstructure, is altered in subjects with premanifest Huntington disease.
  
  
  METHODS
  Local field shift, calculated from 7T MR phase images, was quantified in 13 subjects with premanifest Huntington disease and 13 age- and sex-matched controls. All participants underwent 3T and 7T MR imaging, including volumetric T1 and 7T gradient recalled-echo sequences. Local field shift maps were created from 7T phase data and registered to caudate ROIs automatically parcellated from the 3T T1 images. Huntington disease-specific disease burden and neurocognitive and motor evaluations were also performed and compared with local field shift.
  
  
  RESULTS
  Subjects with premanifest Huntington disease had smaller caudate volume and higher local field shift than controls. A significant correlation between these measurements was not detected, and prediction accuracy for disease state improved with inclusion of both variables. A positive correlation between local field shift and genetic disease burden was also found, and there was a trend toward significant correlations between local field shift and neurocognitive tests of working memory and executive function.
  
  
  CONCLUSIONS
  Subjects with premanifest Huntington disease exhibit differences in 7T MR imaging phase within the caudate nuclei that correlate with genetic disease burden and trend with neurocognitive assessments. Ultra-high-field MR imaging of quantitative phase may be a useful approach for monitoring neurodegeneration in premanifest Huntington disease.
authors.affiliation: From the Departments of Radiology and Biomedical Imaging (A.C.A., J.M.L., A.J., S.J.N., C.P.H.).
authors.forename: A C
authors.initials: AC
authors.lastname: Apple
authors.affiliation: Neurology (K.L.P., G.S., E.J., K.W., G.A.K., S.J.S., J.H.K., M.D.G.), University of California, San Francisco.
authors.forename: K L
authors.initials: KL
authors.lastname: Possin
authors.affiliation: Neurology (K.L.P., G.S., E.J., K.W., G.A.K., S.J.S., J.H.K., M.D.G.), University of California, San Francisco.
authors.forename: G
authors.initials: G
authors.lastname: Satris
authors.affiliation: Neurology (K.L.P., G.S., E.J., K.W., G.A.K., S.J.S., J.H.K., M.D.G.), University of California, San Francisco.
authors.forename: E
authors.initials: E
authors.lastname: Johnson
authors.affiliation: From the Departments of Radiology and Biomedical Imaging (A.C.A., J.M.L., A.J., S.J.N., C.P.H.).
authors.forename: J M
authors.initials: JM
authors.lastname: Lupo
authors.affiliation: From the Departments of Radiology and Biomedical Imaging (A.C.A., J.M.L., A.J., S.J.N., C.P.H.).
authors.forename: A
authors.initials: A
authors.lastname: Jakary
authors.affiliation: Neurology (K.L.P., G.S., E.J., K.W., G.A.K., S.J.S., J.H.K., M.D.G.), University of California, San Francisco.
authors.forename: K
authors.initials: K
authors.lastname: Wong
authors.affiliation: GE Healthcare (D.A.C.K.), Global Applied Sciences Laboratory, Menlo Park, California.
authors.forename: D A C
authors.initials: DA
authors.lastname: Kelley
authors.affiliation: Neurology (K.L.P., G.S., E.J., K.W., G.A.K., S.J.S., J.H.K., M.D.G.), University of California, San Francisco.
authors.forename: G A
authors.initials: GA
authors.lastname: Kang
authors.affiliation: Neurology (K.L.P., G.S., E.J., K.W., G.A.K., S.J.S., J.H.K., M.D.G.), University of California, San Francisco.
authors.forename: S J
authors.initials: SJ
authors.lastname: Sha
authors.affiliation: Neurology (K.L.P., G.S., E.J., K.W., G.A.K., S.J.S., J.H.K., M.D.G.), University of California, San Francisco.
authors.forename: J H
authors.initials: JH
authors.lastname: Kramer
authors.affiliation: Neurology (K.L.P., G.S., E.J., K.W., G.A.K., S.J.S., J.H.K., M.D.G.), University of California, San Francisco.
authors.forename: M D
authors.initials: MD
authors.lastname: Geschwind
authors.affiliation: From the Departments of Radiology and Biomedical Imaging (A.C.A., J.M.L., A.J., S.J.N., C.P.H.).
authors.forename: S J
authors.initials: SJ
authors.lastname: Nelson
authors.affiliation: From the Departments of Radiology and Biomedical Imaging (A.C.A., J.M.L., A.J., S.J.N., C.P.H.) Christopher.Hess@ucsf.edu.
authors.forename: C P
authors.initials: CP
authors.lastname: Hess
mesh_terms: D000328:Adult; D000368:Aged; D002421:Caudate Nucleus / Q000473:pathology*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D007090:Image Interpretation, Computer-Assisted; D007501:Iron / Q000032:analysis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
chemical_list: D007501:Iron
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