title: Dynamic introduction of cell adhesive factor via reversible multicovalent phenylboronic acid/cis-diol polymeric complexes.
abstract: In this work, dynamic introduction of bioactive RGD peptide on a matrix was successfully demonstrated via reversible multicovalent interactions within PBA/cis-diol polymeric complexes. These reversible, stable multiple interaction sites, in addition to a long accessible polymeric linker, enabled "reversible" control of cell adhesion by specific biomolecular exchange (e.g., glucose or fructose). This biomolecule-triggered, noninvasive strategy shows great promise for use in real-time biological research and mimics natural biomolecular feedback systems, thus having potential application in medical diagnoses and regenerative medicine.
authors.affiliation: Orthopedic Institute, Soochow University , 708 Renmin Road, Suzhou, Jiangsu 215007, China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Pan
authors.forename: Bingbing
authors.initials: B
authors.lastname: Guo
authors.forename: Yue
authors.initials: Y
authors.lastname: Ma
authors.forename: Wenguo
authors.initials: W
authors.lastname: Cui
authors.forename: Fan
authors.initials: F
authors.lastname: He
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Huilin
authors.initials: H
authors.lastname: Yang
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Shea
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D001897:Boronic Acids / Q000737:chemistry* / Q000378:metabolism; D002448:Cell Adhesion; D002460:Cell Line; D005632:Fructose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D001897:Boronic Acids; D009842:Oligopeptides; D011108:Polymers; D005632:Fructose; C047981:arginyl-glycyl-aspartic acid; D005947:Glucose; C010686:benzeneboronic acid