title: Perineural administration of dexmedetomidine in combination with ropivacaine prolongs axillary brachial plexus block.
abstract: To evaluate the hypothesis that adding dexmedetomidine to ropivacaine prolongs axillary brachial plexus block. Forty-five patients of ASA I~II and aged 25-60 yr who were scheduled for elective forearm and hand surgery were randomly divided into 3 equal groups and received 40 ml of 0.33% ropivacaine + 1 ml dexmedetomidine (50 μg) (Group DR1), 40 ml of 0.33% ropivacaine + 1 ml dexmedetomidine (100 μg) (group DR2) or 40 ml of 0.33% ropivacaine + 1 ml saline (group R) in a double-blind fashion. The onset and duration of sensory and motor blocks and side effects were recorded. The demographic data and surgical characteristics were similar in each group. Sensory and motor block onset times were the same in the three groups. Sensory and motor blockade durations were longer in group DR2 than in group R (P < 0.05). There was no significant difference in the sensory blockade duration between group DR1 and group R. Bradycardia, hypertension and hypotension were not observed in group R and occurred more often in group DR2 than in group DR1. Dexmedetomidine added to ropivacaine for an axillary brachial plexus block prolongs the duration of the block. However, dexmedetomidine may also lead to side effects such as bradycardia, hypertension, and hypotension.
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: Chang-Song
authors.initials: CS
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Shi
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Sun
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: Shu-Jie
authors.initials: SJ
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: En-You
authors.initials: EY
authors.lastname: Li
keywords: Dexmedetomidine; brachial plexus; ropivacaine
references.citation: Anesth Analg. 1992 May;74(5):719-25
references.pmid: 1567041
references.citation: Rev Bras Anestesiol. 2004 Aug;54(4):473-8
references.pmid: 19471755
references.citation: Anesthesiology. 1996 Sep;85(3):655-74
references.pmid: 8853097
references.citation: Can J Anaesth. 1991 Oct;38(7):870-5
references.pmid: 1742820
references.citation: Anesthesiology. 1997 Aug;87(2):277-84
references.pmid: 9286891
references.citation: Anesthesiology. 2000 Nov;93(5):1345-9
references.pmid: 11046225
references.citation: Acta Anaesthesiol Scand. 2010 Jul;54(6):703-9
references.pmid: 20085547
references.citation: Neuroscience. 1995 May;66(2):427-32
references.pmid: 7477883
references.citation: Anesth Analg. 1996 Nov;83(5):1046-50
references.pmid: 8895283
references.citation: Anesth Analg. 2010 Dec;111(6):1548-51
references.pmid: 20889939
references.citation: Anesth Analg. 2000 May;90(5):1122-8
references.pmid: 10781465
references.citation: Br J Anaesth. 2009 Aug;103(2):268-74
references.pmid: 19541679
references.citation: Rev Bras Anestesiol. 2005 Oct;55(5):525-31
references.pmid: 19468643
references.citation: Anaesthesia. 1999 Dec;54(12):1136-42
references.pmid: 10594409
references.citation: Anesthesiology. 1991 Jan;74(1):3-8
references.pmid: 1670912
references.citation: Acta Anaesthesiol Scand. 2009 Feb;53(2):251-6
references.pmid: 19076110
references.citation: Acta Anaesthesiol Scand. 2006 Feb;50(2):222-7
references.pmid: 16430546
references.citation: Anesth Analg. 2008 Jul;107(1):96-101
references.pmid: 18635472
references.citation: Anesthesiology. 2009 Nov;111(5):1111-9
references.pmid: 19858875
references.citation: Anesthesiology. 2011 Oct;115(4):836-43
references.pmid: 21666435
references.citation: Eur J Anaesthesiol. 2010 Mar;27(3):280-4
references.pmid: 19935071