title: Regulation of microRNAs and their role in liver development, regeneration and disease.
abstract: Since their discovery more than a decade ago microRNAs have been demonstrated to have profound effects on almost every aspect of biology. Numerous studies in recent years have shown that microRNAs have important roles in development and in the etiology and progression of disease. This review is focused on microRNAs and the roles they play in liver development, regeneration and liver disease; particularly chronic liver diseases such as alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, viral hepatitis and primary liver cancer. The key microRNAs identified in liver development and chronic liver disease will be discussed together with, where possible, the target messenger RNAs that these microRNAs regulate to profoundly alter these processes. This article is part of a Directed Issue entitled: The Non-coding RNA Revolution.
authors.affiliation: School of Chemistry and Biochemistry, University of Western Australia, Crawley 6009, WA, Australia. Electronic address: 10509477@student.uwa.edu.au.
authors.forename: Megan L
authors.initials: ML
authors.lastname: Finch
authors.affiliation: Department of Medicine I, Johannes Gutenberg University, Mainz, Germany. Electronic address: marquarj@uni-mainz.de.
authors.forename: Jens U
authors.initials: JU
authors.lastname: Marquardt
authors.affiliation: School of Chemistry and Biochemistry, University of Western Australia, Crawley 6009, WA, Australia; Harry Perkins Institute of Medical Research, Nedlands 6000, WA, Australia. Electronic address: George.Yeoh@uwa.edu.au.
authors.forename: George C
authors.initials: GC
authors.lastname: Yeoh
authors.affiliation: School of Chemistry and Biochemistry, University of Western Australia, Crawley 6009, WA, Australia. Electronic address: Bernard.Callus@uwa.edu.au.
authors.forename: Bernard A
authors.initials: BA
authors.lastname: Callus
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008107:Liver Diseases / Q000235:genetics*; D008115:Liver Regeneration; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: Development; Disease; Liver; MicroRNA; Regeneration