title: Chronic obstructive pulmonary disease (COPD) patients with osteoporotic vertebral compression fractures (OVCFs): improvement of pulmonary function after percutaneous vertebroplasty (VTP).
abstract: OBJECTIVE
  To investigate the changes of respiratory function in patients affected by chronic obstructive pulmonary disease (COPD) with single dorsal osteoporotic vertebral compression fractures (OVCFs) treated with vertebroplasty (VTP).
  
  
  METHODS
  Forty-five patients affected by COPD and single dorsal OVCF underwent VTP (29 men, 16 women; mean age 71.4 years, range 65-77 years). Inclusion criteria were magnetic resonance findings of bone marrow oedema, without intracanal bone fragments and refractory pain to medical treatment for at least 3 months. Osteoporosis was assessed by bone densitometry. Spirometry was performed before and after treatment.
  
  
  RESULTS
  A significant VAS-score decrease was observed 1 week after VTP, with a subsequent decrease over time; vital capacity (VC) and forced vital capacity (FVC) improved over time, reaching a plateau at 3 months. Forced expiratory volume at 1 s (FEV1) did not significantly differ between the pre-VTP values and follow-up values. A significant correlation was observed between VAS-score values and VC, and VAS-score values and FVC. No significant correlation was observed between VAS-score values and FEV1 values.
  
  
  CONCLUSIONS
  VTP improves restrictive ventilatory impairment in patients with moderate and severe COPD affected by single thoracic OVCFs. We recommend this treatment in the management of these patients.
  
  
  CONCLUSIONS
  • Osteoporosis is a major comorbidity in chronic obstructive pulmonary disease (COPD) patients. • Pain due to osteoporotic vertebral compression fractures worsens respiratory failure in COPD. • Vertebroplasty improves ventilatory impairment in COPD patients with osteoporotic vertebral compression fractures.
authors.affiliation: Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Masala
authors.forename: Andrea
authors.initials: A
authors.lastname: Magrini
authors.forename: Amedeo
authors.initials: A
authors.lastname: Taglieri
authors.forename: Giovanni
authors.initials: G
authors.lastname: Nano
authors.forename: Antonio
authors.initials: A
authors.lastname: Chiaravalloti
authors.forename: Eros
authors.initials: E
authors.lastname: Calabria
authors.forename: Roberta
authors.initials: R
authors.lastname: Di Trapano
authors.forename: Antonio
authors.initials: A
authors.lastname: Pietroiusti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Simonetti
mesh_terms: D000368:Aged; D005260:Female; D005471:Fluoroscopy; D005500:Follow-Up Studies; D050815:Fractures, Compression / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D058866:Osteoporotic Fractures / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000503:physiopathology*; D020127:Recovery of Function; D012129:Respiratory Function Tests; D012143:Respiratory Physiological Phenomena; D016103:Spinal Fractures / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome; D054854:Vertebroplasty / Q000379:methods*
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