title: Coexistence of lobular granulomatous mastitis and ductal carcinoma: a fortuitous association?
abstract: A 77-year-old female patient with a medical history significant for hypertension and epilepsy presented with right breast pain of 6-months duration. Examination revealed a hard sub-areola tender mass with irregular borders associated with mild right nipple retraction. Mammography showed a 2.2 x 2.4 cm stellate mass of the right breast. Ultrasound-guided core biopsies of the tumour were performed. Pathological examination revealed a grade II infiltrating ductal carcinoma. The patient underwent right radical mastectomy with homolateral axillary lymphadenectomy. Histological examination of the surgical specimen revealed grade II infiltrating ductal carcinoma concomitant with granulomatous lobular mastitis. To the best of our knowledge, the coexistence of granulomatous lobular mastitis and ductal carcinoma has been described only twice in the English language literature. The theory that chronic inflammation leads to cancer is well documented. Whether our patient had developed cancer from granulomatous lobular mastitis or otherwise is a matter of debate until more cases are encountered and more research is done in the area of breast cancer pathogenesis with regards to it arising from granulomatous lobular mastitis.
authors.forename: F
authors.initials: F
authors.lastname: Limaiem
authors.forename: A
authors.initials: A
authors.lastname: Khadhar
authors.forename: F
authors.initials: F
authors.lastname: Hassan
authors.forename: S
authors.initials: S
authors.lastname: Bouraoui
authors.forename: A
authors.initials: A
authors.lastname: Lahmar
authors.forename: S
authors.initials: S
authors.lastname: Mzabi
mesh_terms: D000368:Aged; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000150:complications* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000150:complications* / Q000473:pathology; D005260:Female; D058890:Granulomatous Mastitis / Q000150:complications* / Q000473:pathology; D006801:Humans