title: Chronic kidney disease and nonalcoholic Fatty liver disease-is there a link?
abstract: Research in recent years has led to the recognition of the importance of nonalcoholic fatty liver disease (NAFLD) and its relationship to the metabolic syndrome (MS). This has led to a growing interest in the potential prognostic value of NAFLD for adverse cardiovascular disease (CVD) outcome. On the other hand, searching for new risk factors for chronic kidney disease (CKD) development and progression is very important. Growing evidence suggests that the MS is an important factor in the pathogenesis of CKD. The best confirmation of this pathogenic link is hypertensive and diabetic nephropathy as the main causes of CKD. Furthermore, the possible link between NAFLD and CKD has also attracted research interest and recent data suggest an association between these two conditions. These findings have fuelled concerns that NAFLD may be a new and added risk factor for the development and progression of CKD. NAFLD and CKD share some important cardiometabolic risk factors and possible common pathophysiological mechanisms, and both are linked to an increased risk of incident CVD events. Therefore, common factors underlying the pathogenesis of NAFLD and CKD may be insulin resistance, oxidative stress, activation of rennin-angiotensin system, and inappropriate secretion of inflammatory cytokines by steatotic and inflamed liver.
authors.affiliation: Division of Internal Medicine, Department of Nephrology and Dialysis, University Hospital Center Rijeka, 51000 Rijeka, Croatia.
authors.forename: L
authors.initials: L
authors.lastname: Orlić
authors.affiliation: Division of Internal Medicine, Department of Nephrology and Dialysis, University Hospital Center Rijeka, 51000 Rijeka, Croatia.
authors.forename: I
authors.initials: I
authors.lastname: Mikolasevic
authors.affiliation: Division of Internal Medicine, Department of Gastroenterology, University Hospital Center Rijeka, 51000 Rijeka, Croatia.
authors.forename: Z
authors.initials: Z
authors.lastname: Bagic
authors.affiliation: Division of Internal Medicine, Department of Nephrology and Dialysis, University Hospital Center Rijeka, 51000 Rijeka, Croatia.
authors.forename: S
authors.initials: S
authors.lastname: Racki
authors.affiliation: Division of Internal Medicine, Department of Gastroenterology, University Hospital Center Rijeka, 51000 Rijeka, Croatia.
authors.forename: D
authors.initials: D
authors.lastname: Stimac
authors.affiliation: Division of Internal Medicine, Department of Gastroenterology, University Hospital Center Rijeka, 51000 Rijeka, Croatia.
authors.forename: S
authors.initials: S
authors.lastname: Milic
references.citation: Atherosclerosis. 2009 Aug;205(2):533-7
references.pmid: 19159884
references.citation: Adv Ther. 2008 Nov;25(11):1141-74
references.pmid: 18972077
references.citation: Atherosclerosis. 2007 Apr;191(2):235-40
references.pmid: 16970951
references.citation: J Hepatol. 2006 Jun;44(6):1196-207
references.pmid: 16618516
references.citation: Clin J Am Soc Nephrol. 2010 Feb;5(2):335-40
references.pmid: 20056762
references.citation: Pediatr Nephrol. 2009 Jun;24(6):1211-7
references.pmid: 19242728
references.citation: Clin Chem. 2007 Jan;53(1):71-7
references.pmid: 17110470
references.citation: Intern Med J. 2010 Jun;40(6):437-42
references.pmid: 19460054
references.citation: Nephrol Dial Transplant. 2003 Aug;18 Suppl 7:vii2-9
references.pmid: 12953023
references.citation: Ultrasound Med Biol. 2010 Nov;36(11):1825-35
references.pmid: 20870345
references.citation: Dig Dis. 2012;30(2):158-62
references.pmid: 22722431
references.citation: Nat Rev Nephrol. 2009 Dec;5(12):677-89
references.pmid: 19935815
references.citation: Hepatology. 2006 Feb;43(2 Suppl 1):S99-S112
references.pmid: 16447287
references.citation: Arab J Gastroenterol. 2012 Dec;13(4):161-5
references.pmid: 23432982
references.citation: Clin J Am Soc Nephrol. 2012 Apr;7(4):588-94
references.pmid: 22383749
references.citation: Hepatology. 2014 Mar;59(3):1174-97
references.pmid: 24002776
references.citation: Diabetologia. 2010 Jul;53(7):1341-8
references.pmid: 20369224
references.citation: Am J Kidney Dis. 2003 Jan;41(1):1-12
references.pmid: 12500213
references.citation: Med Hypotheses. 2014 Jan;82(1):36-9
references.pmid: 24280560
references.citation: Aliment Pharmacol Ther. 2011 Mar;33(5):525-40
references.pmid: 21198708
references.citation: JAMA. 2009 Oct 28;302(16):1782-9
references.pmid: 19861670
references.citation: J Am Soc Nephrol. 2010 Mar;21(3):406-12
references.pmid: 20150538
references.citation: Clin J Am Soc Nephrol. 2010 Dec;5(12):2166-71
references.pmid: 20724519
references.citation: Kidney Blood Press Res. 2013;37(4-5):305-10
references.pmid: 24029696
references.citation: Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):127-33
references.pmid: 17095717
references.citation: J Am Soc Nephrol. 2008 Aug;19(8):1564-70
references.pmid: 18385424
references.citation: Metab Syndr Relat Disord. 2011 Oct;9(5):381-8
references.pmid: 21711121
references.citation: Nephrol Dial Transplant. 2005 Jun;20(6):1048-56
references.pmid: 15814534
references.citation: Cleve Clin J Med. 2008 Oct;75(10):721-8
references.pmid: 18939388
references.citation: J Clin Endocrinol Metab. 2012 Apr;97(4):1268-76
references.pmid: 22337909
references.citation: Nephrol Dial Transplant. 2012 Apr;27(4):1410-5
references.pmid: 21908415
references.citation: Metabolism. 2010 Sep;59(9):1327-30
references.pmid: 20096896
references.citation: Hepatology. 2012 Jun;55(6):2005-23
references.pmid: 22488764
references.citation: Med Hypotheses. 2014 Feb;82(2):205-8
references.pmid: 24365277
references.citation: Clin J Am Soc Nephrol. 2011 Oct;6(10):2364-73
references.pmid: 21852664
references.citation: J Hepatol. 2011 May;54(5):1020-9
references.pmid: 21145850
references.citation: Nutr Metab Cardiovasc Dis. 2010 Oct;20(8):583-90
references.pmid: 19699624
references.citation: Hepatology. 2010 May;51(5):1820-32
references.pmid: 20432259
references.citation: Diabetologia. 2008 Mar;51(3):444-50
references.pmid: 18058083
references.citation: Am J Kidney Dis. 2005 Oct;46(4):577-86
references.pmid: 16183411