title: Increase in the number of tuberculosis cases treated following tuberculin skin testing in first-year schoolchildren in Madagascar.
abstract: BACKGROUND
  Tuberculosis continues to cause unacceptably high levels of disease and death worldwide. Active preventive strategies are required to improve tuberculosis control and to increase the number of cases treated in developing countries. The aim of this study was to evaluate the utility of the tuberculin skin test (TST) in first-year schoolchildren as a means of increasing the number of tuberculosis cases detected through the screening of close contacts.
  
  
  METHODS
  All members of the households of 90 schoolchildren assigned to three groups on the basis of TST category (≤ 5 mm, [5-15)mm, ≥ 15 mm) were screened for sputum smear-positive pulmonary tuberculosis. The percentage detection of tuberculosis in close contacts was compared between TST categories.
  
  
  RESULTS
  We identified 433 close contacts of the 90 schoolchildren, who were then evaluated for tuberculosis. We identified 11 cases of pulmonary tuberculosis among the close contacts (7 already on treatment and 4 previously undiagnosed): 0 in TST category ≤ 5 mm, 3 in TST category [5-15) mm and 8 in TST category ≥ 15 mm). This approach increased the detection of tuberculosis cases by a factor of 1.6 in first-year schoolchildren of the TST ≥ 5 mm group.
  
  
  CONCLUSIONS
  TST in first-year schoolchildren is a potentially effective method for improving the detection of tuberculosis in close contacts.
authors.affiliation: Epidemiology Unit, Pasteur Institute in Antananarivo, Antananarivo, Madagascar.
authors.forename: Rila
authors.initials: R
authors.lastname: Ratovoson
authors.affiliation: Epidemiology Unit, Pasteur Institute in Antananarivo, Antananarivo, Madagascar.
authors.forename: Voamalala
authors.initials: V
authors.lastname: Raharimanga
authors.affiliation: Mycobacteria Unit, Pasteur Institute in Antananarivo, Antananarivo, Madagascar.
authors.forename: Niaina
authors.initials: N
authors.lastname: Rakotosamimanana
authors.affiliation: Tuberculosis Treatment Center, Ministry of Health, Antananarivo, Madagascar.
authors.forename: B
authors.initials: B
authors.lastname: Ravaloson
authors.affiliation: Epidemiology Unit, Pasteur Institute in Antananarivo, Antananarivo, Madagascar.
authors.forename: Maherisosa
authors.initials: M
authors.lastname: Ratsitorahina
authors.affiliation: Epidemiology Unit, Pasteur Institute in Antananarivo, Antananarivo, Madagascar.
authors.forename: Rindra
authors.initials: R
authors.lastname: Randremanana
authors.affiliation: Mycobacteria Unit, Pasteur Institute in Antananarivo, Antananarivo, Madagascar.
authors.forename: Herimanana
authors.initials: H
authors.lastname: Ramarokoto
authors.affiliation: Epidemiology Unit, Pasteur Institute in Antananarivo, Antananarivo, Madagascar.
authors.forename: Soatiana
authors.initials: S
authors.lastname: Rajatonirina
authors.affiliation: Mycobacteria Unit, Pasteur Institute in Antananarivo, Antananarivo, Madagascar.
authors.forename: Voahangy
authors.initials: V
authors.lastname: Rasolofo
authors.affiliation: Epidemiology Unit, Pasteur Institute in Antananarivo, Antananarivo, Madagascar; Epidemiology Unit, Pasteur Institute in Dakar, Dakar, Senegal.
authors.forename: Vincent
authors.initials: V
authors.lastname: Richard
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D008270:Madagascar / Q000453:epidemiology; D008297:Male; D014373:Tuberculin / Q000032:analysis*; D014374:Tuberculin Test; D014376:Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology
chemical_list: D014373:Tuberculin
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