title: Inflammation and Coagulation as Mediators in the Relationships Between Religious Attendance and Functional Limitations in Older Adults.
abstract: OBJECTIVE
  The aim of this study was to examine inflammation and coagulation, which are positively linked to disability and inversely linked to increased religious attendance, as mediators in the cross-sectional relationships between religious attendance and functional status.
  
  
  METHODS
  Frequency of attendance and limitations in basic activities of daily living (ADLs), instrumental activities (IADLs), and mobility were assessed in 1,423 elders.
  
  
  RESULTS
  More frequent attendance was associated with fewer ADL, IADL, and mobility limitations, and with lower levels of inflammation and coagulation including interleukin-6, soluble vascular cell adhesion molecule, and D-dimer. Inflammation and coagulation partially mediated the associations between attendance and function. Eight percent of the effect of attendance on ADL (p = .014), 5% of the effect on IADL (p = .003), and 8% of the effect on mobility (p = .001) limitations were due to inflammation and coagulation.
  
  
  CONCLUSIONS
  Relationships between attendance and function may be due in part to lower levels of inflammation and coagulation among elders who attend services.
authors.affiliation: Duke University Medical Center, Durham, NC, USA celia.hybels@duke.edu.
authors.forename: Celia F
authors.initials: CF
authors.lastname: Hybels
authors.affiliation: Duke University Medical Center, Durham, NC, USA.
authors.forename: Linda K
authors.initials: LK
authors.lastname: George
authors.affiliation: Duke University Medical Center, Durham, NC, USA.
authors.forename: Dan G
authors.initials: DG
authors.lastname: Blazer
authors.affiliation: Duke University Medical Center, Durham, NC, USA.
authors.forename: Carl F
authors.initials: CF
authors.lastname: Pieper
authors.affiliation: Duke University Medical Center, Durham, NC, USA.
authors.forename: Harvey J
authors.initials: HJ
authors.lastname: Cohen
authors.affiliation: Duke University Medical Center, Durham, NC, USA King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Harold G
authors.initials: HG
authors.lastname: Koenig
keywords: aging; coagulation; functional status; inflammation; religion
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