title: Bone mineral density of the femur in autopsy retrieved total knee arthroplasties.
abstract: Bone mineral density (BMD), as measured by DEXA, can vary depending on bone rotation and fat content of soft tissues. We performed DEXA measurements, under controlled positioning, on 24 autopsy-retrieved femora from patients who had fully functional and asymptomatic successful TKA to determine periprosthetic BMD changes and compared results to 24 normal cadaveric femora. In TKA specimens, BMD was affected by gender, preoperative diagnosis, and zone under analysis. The lowest mean BMD was in the anterior femoral condylar zone. Males had higher mean BMD at all zones while patients with preoperative diagnosis of osteoarthritis had higher BMD in the posterior condylar zone. The mean BMD in the anterior femoral condylar zone in TKA specimens was significantly lower than in normal specimens without arthroplasties, most likely due to stress shielding.
authors.affiliation: Center for Advanced Orthopedics at Larkin, Miami, Florida.
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Lavernia
authors.affiliation: Arthritis Surgery Research Foundation, Miami, Florida.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Rodriguez
authors.affiliation: Center for Advanced Orthopedics at Larkin, Miami, Florida; Arthritis Surgery Research Foundation, Miami, Florida.
authors.forename: David A
authors.initials: DA
authors.lastname: Iacobelli
authors.affiliation: Johns Hopkins Orthopaedics at Good Samaritan Hospital, Baltimore, Maryland.
authors.forename: David S
authors.initials: DS
authors.lastname: Hungerford
authors.affiliation: Department of Orthopaedic Surgery, Kaleida/Buffalo General Hospital, New York.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Krackow
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D058070:Asymptomatic Diseases; D001843:Bone Cements / Q000627:therapeutic use; D015519:Bone Density; D002102:Cadaver; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging* / Q000502:physiology / Q000601:surgery*; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000502:physiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000209:etiology; D011446:Prospective Studies; D012399:Rotation; D012727:Sex Characteristics; D013314:Stress, Mechanical; D016474:Weight-Bearing
chemical_list: D001843:Bone Cements
keywords: DEXA; bone mineral density; distal femur; knee arthroplasty; stress shielding; total knee arthroplasty