title: Synthesis, characterization and antibacterial activity of a Schiff base derived from cephalexin and sulphathiazole and its transition metal complexes.
abstract: Metal(II) coordination compounds of a cephalexin Schiff base (HL) derived from the condensation of cephalexin antibiotic with sulphathiazole were synthesized. The Schiff base ligand, mononuclear [ML(OAc)(H2O)2] (M(II)=Mn, Co, Ni, Zn) complexes and magnetically diluted trinuclear copper(II) complex [Cu3L(OH)5] were characterized by several techniques, including elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, EPR and (1)H NMR spectral studies. The analytical and molar conductance values indicated that the acetate ions coordinate to the metal ions. The Schiff base ligand HL behaves as a monoanionic tridentate NNO and tetradentate NNOO chelating agent in the mono and trinuclear complexes respectively.
authors.affiliation: Department of Chemistry, Universidad de Oriente, Cumana 6101, Venezuela. Electronic address: juananacona@hotmail.com.
authors.forename: J R
authors.initials: JR
authors.lastname: Anacona
authors.affiliation: Department of Chemistry, Universidad de Oriente, Cumana 6101, Venezuela.
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Rodriguez
authors.affiliation: Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Valparaíso, Chile.
authors.forename: Juan
authors.initials: J
authors.lastname: Camus
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002506:Cephalexin / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013057:Spectrum Analysis; D000077589:Sulfathiazole; D013432:Sulfathiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D012545:Schiff Bases; D013432:Sulfathiazoles; D002506:Cephalexin; D000077589:Sulfathiazole
keywords: Magnetic studies; Schiff base containing cephalexin; Schiff base metal complexes; Spectroscopic studies; Synthesis; Synthesis cephalexin derivative