title: Hippocampal perivascular spaces are related to aging and blood pressure but not to cognition.
abstract: The risk factors of hippocampal dilated perivascular spaces (H-dPVS), their radiological relevance and their impact on cognitive performance remain under investigation. These aspects were evaluated in 1818 stroke- and dementia-free participants enrolled in the 3C-Dijon MRI study, using logistic regression, multiple linear regression, and Cox models. At study entry, the load of H-dPVS was found strongly associated with age and hypertension (degree 2 vs. degree 0: odds ratio: 1.16; 95% confidence interval: 1.02-1.33 and odds ratio: 1.98; 95% confidence interval: 1.39-2.81, respectively) and positively related to the presence of lacunar infarcts, white-matter hyperintensities volume, and hippocampal volume (p ≤ 0.024). Load of H-dPVS was not related to baseline cognitive performance (p > 0.05). Cox regression modeling did not show a significant relationship between the load of H-dPVS and incident dementia risk (p > 0.05). The present results support that both aging and blood pressure do play a key role in the development of H-dPVS in the older population. In contrast with the dilated perivascular spaces located in white matter or basal ganglia, the load of H-dPVS does not appear associated with occurrence of dementia.
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Beijing, China; Univ Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Ming
authors.initials: M
authors.lastname: Yao
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Beijing, China.
authors.forename: Yi-Cheng
authors.initials: YC
authors.lastname: Zhu
authors.affiliation: Univ Pierre et Marie Curie Paris 6, Paris, France; INSERM UMR708, Bordeaux, France.
authors.forename: Aïcha
authors.initials: A
authors.lastname: Soumaré
authors.affiliation: Univ Pierre et Marie Curie Paris 6, Paris, France; INSERM UMR708, Bordeaux, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Dufouil
authors.affiliation: Institut Universitaire de France, Paris, France; CNRS-CEA UMR 6232, Caen, France; Groupe Imagerie Neurofonctionelle, Caen, France; University Caen Basse-Normandie, Caen, France; CHU de Caen, Caen, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Mazoyer
authors.affiliation: Univ Pierre et Marie Curie Paris 6, Paris, France; INSERM UMR708, Bordeaux, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
authors.affiliation: Univ Paris Diderot, Sorbonne Paris Cité, Paris, France; INSERM UMR 1161 and DHU NeuroVasc, Paris, France; Department of Neurology, AP-HP, Paris, France. Electronic address: hugues.chabriat@lrb.aphp.fr.
authors.forename: Hugues
authors.initials: H
authors.lastname: Chabriat
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001794:Blood Pressure / Q000502:physiology*; D003071:Cognition; D015331:Cohort Studies; D004108:Dilatation, Pathologic; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000473:pathology* / Q000503:physiopathology; D016015:Logistic Models; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D016016:Proportional Hazards Models; D012307:Risk Factors
keywords: Cognition; Hippocampal dilated perivascular spaces; MRI; Risk factors