title: Toward an understanding of the gene-specific and global logic of inducible gene transcription.
abstract: Virtually all living organisms have evolved mechanisms to adapt to their environment by sensing environmental stresses and inducing the transcription of appropriate sets of response genes in a coordinated fashion. In the vertebrate immune system, the highly selective response to an environmental stimulus, often an invading microorganism, plays an especially important role in regulating the activities of, and interactions among, the many cell types involved in innate and adaptive immunity. It is now widely appreciated that the selective response to a stimulus requires the concerted action of signal transduction pathways, transcription factors, and chromatin structure. Many proteins and pathways that help to regulate a response have been characterized. However, our understanding of the gene-specific and global logic through which a highly selective response is elicited has only recently begun to emerge.
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095 smale@mednet.ucla.edu.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Smale
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095.
authors.forename: Scott E
authors.initials: SE
authors.lastname: Plevy
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095.
authors.forename: Amy S
authors.initials: AS
authors.lastname: Weinmann
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095.
authors.forename: Vladimir R
authors.initials: VR
authors.lastname: Ramirez-Carrozzi
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095.
authors.forename: Scott D
authors.initials: SD
authors.lastname: Pope
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095.
authors.forename: Dev M
authors.initials: DM
authors.lastname: Bhatt
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095.
authors.forename: Ann-Jay
authors.initials: AJ
authors.lastname: Tong
mesh_terms: D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D053762:Interleukin-12 Subunit p40 / Q000378:metabolism; D051379:Mice; D009707:Nucleosomes / Q000378:metabolism; D017423:Sequence Analysis, RNA; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; C500879:IL12B protein, human; D053762:Interleukin-12 Subunit p40; D009707:Nucleosomes; D014157:Transcription Factors