title: The evaluation of fibrin sealants and tissue adhesives in oral surgery among patients with bleeding disorders.
abstract: OBJECTIVE
  The aim of this study was to evaluate the efficiency of two local hemostatic agents administered with apreoperative dose of replacement therapy in patients with bleeding disorders undergoing oral surgery.
  
  
  METHODS
  The study included 21 patients that were randomly divided into 3 groups. Patients in Group1 (n = 7) received preoperative replacement therapy and postoperative fibrin sealant applied to the surgical site. Patientsin Group 2 (n = 7) received preoperative replacement therapy and postoperative tissue adhesive applied to the surgicalsite. Patients in Group 3 (n = 7) were given replacement therapy pre- and postoperatively.
  
  
  RESULTS
  Postoperative bleeding was not observed in 17 of the 21 patients, including 5 in Group 1 (71.42%), 6 in Group2 (85.71%), and 6 in Group 3 (85.71%). Hemorrhagic complications occurred in only 4 of the 21 patients.
  
  
  CONCLUSIONS
  The use of fibrin sealant and tissue adhesive was beneficial, as they reduced the level of factor concentratesused for replacement therapy and resulted in rapid hemostasis at the surgical site, facilitating the ability to performserial surgical procedures concurrently.
authors.affiliation: Istanbul University, Faculty of Dentistry, Department of Oral Surgery and Medicine , İstanbul, Turkey.
authors.forename: Gülsüm
authors.initials: G
authors.lastname: Ak
authors.affiliation: Hospitadent Oral and Dental Health Rehabilitation Center, Oral Surgery Department, İstanbul, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Alpkılıç Başkırt
authors.affiliation: Istanbul University, Faculty of Dentistry, Department of Oral Surgery and Medicine , İstanbul, Turkey.
authors.forename: Esma
authors.initials: E
authors.lastname: Kürklü
authors.affiliation: Istanbul University, Faculty of Dentistry, Department of Oral Surgery and Medicine , İstanbul, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Koray
authors.affiliation: Istanbul University, Faculty of Dentistry, Department of Oral Surgery and Medicine , İstanbul, Turkey.
authors.forename: Hakkı
authors.initials: H
authors.lastname: Tanyeri
authors.affiliation: İstanbul University, Cerrahpaşa School of Medicine, Department of Pediatric Hematology-Oncology, İstanbul, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Zülfikar
keywords: Bleeding disorders; Fibrin sealants; Hemophilia; Tissue adhesive; Tooth extraction
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