title: [The concept of infectious diseases pathogenesis].
abstract: In this article a concept of infectious disease pathogenesis as consisted with clinical symptoms is provided. The course of disease, immediate and long-term consequences depend on the mode of entry. If the infection comes via oropharynx, airway, gastrointestinal tract or via skin, the immune system provides adequate immune response. This leads to typical symptoms, cyclical clinic progression and usually to the recovery with the formation of full sterile immunity. In case of parenteral way of infection, which includes perinatal way, there is no full mode of entry, the disease takes chronic course involving visceral organs because of different mechanisms of affinity and new tropic organ involving. For the full sanogenesis germ or its mediators should persist in the primary focus of infection. It is suggested, that HIV, HCV, hepatitis B virus, tetanus, rabies and other infectious diseases with inner organs involvement, as well as all slow infections, should be treated as infectious diseases with the parental way of infection, proceeding with affinity changings, which lead to the appearance of new tropic sites in visceral organs. The theory of the mode of entry, affinity, appearance of tropic sites in visceral organs should form the basis of modern infectology.
authors.forename: V F
authors.initials: VF
authors.lastname: Uchaĭkin
authors.forename: O V
authors.initials: OV
authors.lastname: Shamsheva
mesh_terms: D002908:Chronic Disease; D003141:Communicable Diseases / Q000145:classification / Q000175:diagnosis / Q000503:physiopathology; D018450:Disease Progression; D006801:Humans; D058958:Organs at Risk; D062072:Patient Acuity; D063189:Symptom Assessment