title: Amniotic coenzyme Q10: is it related to pregnancy outcomes?
abstract: Coenzyme Q10 (CoQ10 or ubiquinone) is an essential component of the mitochondrial electron transport chain and is also present in various cellular membranes and in plasma lipoproteins. Diabetes, cardiovascular, neurodegenerative, and preeclampsia diseases are all associated with an alteration of CoQ10 level or its redox status. During pregnancy, we note that the plasma content of CoQ10 is significantly higher than amniotic. In the fetal growth restriction group, amniotic total CoQ10 levels were significantly higher versus healthy, while the amniotic oxygen radical absorbing capacity level was significantly lower. A significant negative correlation was observed between amniotic total CoQ10 and birthweight. Our observation leads to the hypothesis that the amniotic midtrimester CoQ10 content may be a marker of subsequent obstetric complications.
authors.affiliation: Department of Clinical Sciences, Polytechnic University of Marche , Ancona, Italy .
authors.forename: Stefano Raffaele
authors.initials: SR
authors.lastname: Giannubilo
authors.forename: Luca
authors.initials: L
authors.lastname: Tiano
authors.forename: Andrea
authors.initials: A
authors.lastname: Ciavattini
authors.forename: Beatrice
authors.initials: B
authors.lastname: Landi
authors.forename: Paola
authors.initials: P
authors.lastname: Carnevali
authors.forename: Federica
authors.initials: F
authors.lastname: Principi
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Littarru
authors.forename: Laura
authors.initials: L
authors.lastname: Mazzanti
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism; D005322:Premature Rupture of Fetal Membranes / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress; D011247:Pregnancy; D011256:Pregnancy Outcome; D017382:Reactive Oxygen Species; D012307:Risk Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D014451:Ubiquinone; C024989:coenzyme Q10
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