title: Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report.
abstract: Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a non-peptidyl low molecular weight radical scavenger (IAC) therapy may counteract this factor, ultimately providing some protection after acute phase renal I/R injury. The aim of this preliminary study was to assess the ability of IAC to reduce acute kidney injury in C57BL/6 mice after 30-minute of bilateral ischemia followed by reperfusion. The rise in serum creatinine level was higher in C57BL/6 control mice after I/R when compared to IAC (1 mg)-treated mice. Control mice showed greater body weight loss compared to IAC-treated mice, and at pathology, reduced signs of tubular necrosis were also evident in IAC-treated mice. These preliminary evidences lay the basis for more comprehensive studies on the positive effects of IAC as a complementary therapeutic approach for acute phase renal I/R injury.
authors.affiliation: Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA USA ; DiSTeBA, Universita' del Salento, Lecce, Italy ; Medicine, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bassi
authors.affiliation: Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Vergani
authors.affiliation: Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA USA ; Medicine, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: D'Addio
authors.affiliation: Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA USA.
authors.forename: Moufida
authors.initials: M
authors.lastname: Ben Nasr
authors.affiliation: Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA USA ; Department of Accident and Emergency, ASL, Bologna, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Mocci
authors.affiliation: Renal Research Laboratory, Fondazione IRCCS Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, Milan, Italy.
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Rastaldi
authors.affiliation: Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
authors.forename: Takaharu
authors.initials: T
authors.lastname: Ichimura
authors.affiliation: Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
authors.forename: Joseph Vincent
authors.initials: JV
authors.lastname: Bonventre
authors.affiliation: Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA USA ; Medicine, San Raffaele Scientific Institute, Milan, Italy ; Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fiorina
keywords: Inflammation; Ischemia/reperfusion; Kidney disease; Kidney transplantation; Radical oxygen species
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