title: Asymmetric addition of triethylaluminium to aromatic aldehydes catalyzed by titanium-(5,5'-biquinoline-6,6'-diol) complexes.
abstract: A novel convenient procedure for the resolution of 5,5'-biquinoline-6,6'-diol (BIQOL) was achieved by separating the corresponding diastereomeric mixture of (S)-(+)-camphorsulfonates on a semiprepared XDB-C8 column followed by hydrolysis. The efficient asymmetric addition of triethylaluminium to aromatic aldehydes catalyzed by Ti-(+)/(-)BIQOL complexes under mild conditions is described. The reactions led to the formation of 1-arylpropan-1-ol in up to 87.5% ee.
authors.affiliation: School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Ou
authors.forename: Guo-Shu
authors.initials: GS
authors.lastname: Chen
authors.forename: Tian-Hui
authors.initials: TH
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Xie
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Liang
authors.forename: Li-Qiong
authors.initials: LQ
authors.lastname: Xie
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Chen
keywords: BINOL-type ligands; BIQOL; asymmetric addition; resolution; triethylaluminium