title: Cancellous bone response to strontium-doped hydroxyapatite in osteoporotic rats.
abstract: OBJECTIVE
  The objective of this study was to investigate cancellous bone response to strontium-doped hydroxyapatite (SrHA) in ovariectomized (OVX) rats.
  
  
  METHODS
  Hydroxyapatite (HA) and 10%SrHA (HA with 10 mol% calcium substituted by strontium) implants were prepared and characterized by scanning electronic microscopy (SEM), energy dispersive microanalysis (EDX) and X-ray diffraction (XRD). Twelve weeks after bilateral ovariectomy, 20 rats randomly received HA or 10%SrHA implants in the right distal femur, with 10 animals in each group. Eight weeks after implantation, specimens were harvested and analyzed by micro-computed tomography (micro-CT) and histology.
  
  
  RESULTS
  Compared with HA, 10%SrHA raised the percentage bone volume by 42.6%, bone-to-implant contact by 47.1%, mean trabecular number by 27.3%, mean trabecular thickness by 31.5% and mean connectivity density by 37.4%, while it decreased mean trabecular separation by 20.1% in micro-CT evaluation. 10%SrHA also increased the bone area density by 47.6% in histological analysis.
  
  
  CONCLUSIONS
  With the HA implants as controls, the 10%SrHA implants were shown to increase bone density and bone-to-implant contact, and improve trabecular architecture in the vicinity of implant surfaces.
authors.affiliation: 1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu - PR China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Li
authors.forename: En
authors.initials: E
authors.lastname: Luo
authors.forename: Songsong
authors.initials: S
authors.lastname: Zhu
authors.forename: Jihua
authors.initials: J
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology; D017886:Durapatite / Q000737:chemistry / Q000493:pharmacokinetics; D005260:Female; D005269:Femur / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D010024:Osteoporosis / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D051381:Rats; D017207:Rats, Sprague-Dawley; D013324:Strontium / Q000737:chemistry / Q000494:pharmacology; D055114:X-Ray Microtomography
chemical_list: D018786:Bone Substitutes; D017886:Durapatite; D013324:Strontium