title: [Sudden blast crisis of chronic myeloid leukemia after a 13-year durable remission following allogeneic bone marrow transplantation and donor lymphocyte infusion].
abstract: We describe a rare case of sudden blast crisis of chronic myeloid leukemia that occurred after a 13-year durable remission, following allogeneic bone marrow transplantation and donor lymphocyte infusion. A 55-year-old Japanese man was diagnosed with chronic-phase chronic myeloid leukemia 24 years previously. He underwent allogeneic bone marrow transplantation 2 years after diagnosis. Although the disease recurred 6 years after transplantation, the patient achieved remission again by a donor lymphocyte infusion. Despite a 13-year durable remission, the disease later relapsed into a sudden blast crisis. Prednisolone and vincristine combined with imatinib mesylate effectively achieved a major molecular response. However, the disease relapsed repeatedly with central nervous system infiltration. Dasatinib and intrathecal methotrexate, cytarabine, and dexamethasone administration via the Ommaya reservoir controlled disease progression. Nevertheless, the disease became refractory to treatment with the emergence of a T315I Bcr-Abl gene mutation. The patient eventually died 43 months post crisis.
authors.affiliation: Dept. of Hematology and Oncology, University of Fukui.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Ookura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Eiju
authors.initials: E
authors.lastname: Negoro
authors.forename: Naoko
authors.initials: N
authors.lastname: Hosono
authors.forename: Shinji
authors.initials: S
authors.lastname: Kishi
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Inai
authors.forename: Yuji
authors.initials: Y
authors.lastname: Wano
authors.forename: Kana
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Iwasaki
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Morita
authors.forename: Takanori
authors.initials: T
authors.lastname: Ueda
mesh_terms: D001752:Blast Crisis / Q000628:therapy*; D016026:Bone Marrow Transplantation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D017710:Lymphocyte Transfusion; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012074:Remission Induction; D013997:Time Factors; D014184:Transplantation, Homologous