title: The blood glucose level increased in parallel with the heart rate following cilostazol administration in three diabetic patients.
abstract: Cilostazol, a phosphodiesterase III inhibitor, is known to increase the heart rate; however, its effects on glucose metabolism remain unclear. We observed that the blood glucose level varied in parallel with the heart rate immediately after starting or stopping cilostazol therapy in three patients with type 2 diabetes. This finding indicates that cilostazol induces hyperglycemia and tachycardia in a portion of diabetic patients, presumably via similar pharmacological effects on different organs. Much more attention should be paid to the possible effects of cilostazol on glycemic control, including taking into consideration the risk-benefit ratio of cilostazol use and individual circumstances.
authors.affiliation: Department of Internal Medicine, National Hospital Organization Matsumoto Medical Center Matsumoto Hospital, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Aoki
authors.forename: Mika
authors.initials: M
authors.lastname: Shimizu
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Watanabe
mesh_terms: D000369:Aged, 80 and over; D001786:Blood Glucose / Q000187:drug effects*; D000077407:Cilostazol; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D058987:Phosphodiesterase 3 Inhibitors / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013777:Tetrazoles / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D058987:Phosphodiesterase 3 Inhibitors; D010975:Platelet Aggregation Inhibitors; D013777:Tetrazoles; D000077407:Cilostazol