title: Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III.
abstract: OBJECTIVE
  Bayley-III scales are currently used to evaluate outcomes of term infants following hypothermia therapy, while all before reported outcomes in this population have used Bayley-II. Our objectives were to determine the incidence of abnormal neurodevelopmental outcomes using Bayley III and the predictive value of Magnetic resonance imaging (MRI) in infants who received systemic hypothermia.
  
  
  METHODS
  We conducted a prospective cohort study of inborn infants who underwent hypothermia for moderate/severe neonatal encephalopathy from October 2005-November 2011.
  
  
  RESULTS
  Eighty newborns underwent hypothermia (incidence of 1/1000). Of the survivors, 89% had Bayley-III performed around 24 months of age. An abnormal outcome using Bayley-III <85 occurred in 50%, while Bayley III <70 occurred in 13%. MRI predicted Bayley III<85 with sensitivity of 73%, specificity of 84%, positive-predictive value of 84% and negative-predictive value of 74%.
  
  
  CONCLUSIONS
  A Bayley-III 85 cutoff identifies a disability rate of 50%, and MRI was predictive of abnormal outcomes. Findings can be useful for counseling of families and planning of future studies using Bayley III.
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, The University of Texas, Southwestern Medical Center, Dallas, TX, USA.
authors.forename: L F
authors.initials: LF
authors.lastname: Chalak
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, The University of Texas, Southwestern Medical Center, Dallas, TX, USA.
authors.forename: T L
authors.initials: TL
authors.lastname: DuPont
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, The University of Texas, Southwestern Medical Center, Dallas, TX, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Sánchez
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, The University of Texas, Southwestern Medical Center, Dallas, TX, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lucke
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, The University of Texas, Southwestern Medical Center, Dallas, TX, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Heyne
authors.affiliation: Department of Radiology, The University of Texas, Southwestern Medical Center, Dallas, TX, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Morriss
authors.affiliation: Department of Radiology, The University of Texas, Southwestern Medical Center, Dallas, TX, USA.
authors.forename: N K
authors.initials: NK
authors.lastname: Rollins
mesh_terms: D002657:Child Development; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000523:psychology / Q000628:therapy*; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D017063:Outcome Assessment, Health Care; D011237:Predictive Value of Tests
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