title: Studies on drug-polymer interaction, in vitro release and cytotoxicity from chitosan particles excipient.
abstract: Nonobvious controlled polymeric pharmaceutical excipient, chitosan nanoparticles (CS-NPs) for lenalidomide encapsulation were geared up by the simple ionic cross linking method to get better bioavailability and to reduce under as well as overloading of hydrophobic and sparingly soluble drug lenalidomide towards cancer cells. Lenalidomide loaded chitosan nanoparticles (LND-CS-NPs) were in the size range of 220-295 nm and characterized by DLS, TEM, FT-IR, TGA and XRD. Encapsulation of lenalidomide over chitosan nanoparticles was observed about 99.35% using UV spectrophotometry method. In vitro release and the cytotoxic studies were performed using LND-CS-NPs. This study implies the new drug delivery route for lenalidomide and illustrates that the CS-NPs serves as the effective pharmaceutical carrier for sustained delivery of lenalidomide.
authors.affiliation: Department of Chemistry, D.K.M. College for Women, Vellore, Tamil Nadu, India.
authors.forename: Thandapani
authors.initials: T
authors.lastname: Gomathi
authors.affiliation: Indian Institute of Chromatography and Mass Spectrometry, Chennai, Tamil Nadu, India.
authors.forename: C
authors.initials: C
authors.lastname: Govindarajan
authors.affiliation: Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India.
authors.forename: Maximas H
authors.initials: MH
authors.lastname: Rose H R
authors.affiliation: Department of Chemistry, D.K.M. College for Women, Vellore, Tamil Nadu, India. Electronic address: drparsu8@gmail.com.
authors.forename: P N
authors.initials: PN
authors.lastname: Sudha
authors.affiliation: Department of Chemistry, Islamiah College, Vaniyambadi, Tamil Nadu, India.
authors.forename: P K Mohamed
authors.initials: PK
authors.lastname: Imran
authors.affiliation: Department of Marine Bio Convergence Science and Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, South Korea. Electronic address: venkatjchem@gmail.com.
authors.forename: Jayachandran
authors.initials: J
authors.lastname: Venkatesan
authors.affiliation: Department of Marine Bio Convergence Science and Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, South Korea. Electronic address: sknkim@pknu.ac.kr.
authors.forename: Se-Kwon
authors.initials: SK
authors.lastname: Kim
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D018360:Crystallography, X-Ray; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D000077269:Lenalidomide; D008027:Light; D061986:MCF-7 Cells; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D009369:Neoplasms / Q000473:pathology; D010316:Particle Size; D033362:Powder Diffraction; D012542:Scattering, Radiation; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000379:methods; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000737:chemistry; D013818:Thermogravimetry
chemical_list: D020533:Angiogenesis Inhibitors; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D013792:Thalidomide; D048271:Chitosan; D000077269:Lenalidomide
keywords: Biodegradable polymer; Lenalidomide; Nanoencapsulation; Nanoparticles; New drug delivery route; Pharmaceutical carrier