title: Divergent CD4+ T memory stem cell dynamics in pathogenic and nonpathogenic simian immunodeficiency virus infections.
abstract: Recent studies have identified a subset of memory T cells with stem cell-like properties (T(SCM)) that include increased longevity and proliferative potential. In this study, we examined the dynamics of CD4(+) T(SCM) during pathogenic SIV infection of rhesus macaques (RM) and nonpathogenic SIV infection of sooty mangabeys (SM). Whereas SIV-infected RM show selective numeric preservation of CD4(+) T(SCM), SIV infection induced a complex perturbation of these cells defined by depletion of CD4(+)CCR5(+) T(SCM), increased rates of CD4(+) T(SCM) proliferation, and high levels of direct virus infection. The increased rates of CD4(+) T(SCM) proliferation in SIV-infected RM correlated inversely with the levels of central memory CD4(+) T cells. In contrast, nonpathogenic SIV infection of SM evidenced preservation of both CD4(+) T(SCM) and CD4(+) central memory T cells, with normal levels of CD4(+) T(SCM) proliferation, and lack of selective depletion of CD4(+)CCR5(+) T(SCM). Importantly, SIV DNA was below the detectable limit in CD4(+) T(SCM) from 8 of 10 SIV-infected SM. We propose that increased proliferation and infection of CD4(+) T(SCM) may contribute to the pathogenesis of SIV infection in RM.
authors.affiliation: Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329;
authors.forename: Emily K
authors.initials: EK
authors.lastname: Cartwright
authors.forename: Colleen S
authors.initials: CS
authors.lastname: McGary
authors.forename: Barbara
authors.initials: B
authors.lastname: Cervasi
authors.forename: Luca
authors.initials: L
authors.lastname: Micci
authors.forename: Benton
authors.initials: B
authors.lastname: Lawson
authors.forename: Sarah T C
authors.initials: ST
authors.lastname: Elliott
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Collman
authors.forename: Steven E
authors.initials: SE
authors.lastname: Bosinger
authors.forename: Mirko
authors.initials: M
authors.lastname: Paiardini
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Vanderford
authors.forename: Ann
authors.initials: A
authors.lastname: Chahroudi
authors.forename: Guido
authors.initials: G
authors.lastname: Silvestri
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D016665:Cercocebus atys; D007156:Immunologic Memory; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013997:Time Factors
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