title: Investigating microRNA-target interaction-supported tissues in human cancer tissues based on miRNA and target gene expression profiling.
abstract: Recent studies have revealed that a small non-coding RNA, microRNA (miRNA) down-regulates its mRNA targets. This effect is regarded as an important role in various biological processes. Many studies have been devoted to predicting miRNA-target interactions. These studies indicate that the interactions may only be functional in some specific tissues, which depend on the characteristics of an miRNA. No systematic methods have been established in the literature to investigate the correlation between miRNA-target interactions and tissue specificity through microarray data. In this study, we propose a method to investigate miRNA-target interaction-supported tissues, which is based on experimentally validated miRNA-target interactions. The tissue specificity results by our method are in accordance with the experimental results in the literature.
  
  
  METHODS
  Our analysis results are available at http://tsmti.mbc.nctu.edu.tw/ and http://www.stat.nctu.edu.tw/hwang/tsmti.html.
authors.affiliation: Institute of Statistics, National Chiao Tung University, Hsinchu, Taiwan.
authors.forename: Wan J
authors.initials: WJ
authors.lastname: Hsieh
authors.affiliation: Department of Biological Science and Technology, Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan.
authors.forename: Feng-Mao
authors.initials: FM
authors.lastname: Lin
authors.affiliation: Department of Biological Science and Technology, Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan.
authors.forename: Hsien-Da
authors.initials: HD
authors.lastname: Huang
authors.affiliation: Institute of Statistics, National Chiao Tung University, Hsinchu, Taiwan.
authors.forename: Hsiuying
authors.initials: H
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D016000:Cluster Analysis; D019295:Computational Biology / Q000379:methods; D030561:Databases, Nucleic Acid; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020407:Internet; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D034622:RNA Interference; D012333:RNA, Messenger / Q000235:genetics*; D014015:Tissue Banks
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger
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