title: Enantioselective construction of [6,5,6]-carbocyclic systems by organo/metal-catalyzed sequential reactions.
abstract: An efficient strategy for the enantioselective construction of [6,5,6]-carbocyclic compounds has been established via one-pot reaction of (E)-4-(2-ethynylphenyl)but-3-en-2-ones with maleimide sequentially catalyzed by cinchona alkaloid-based primary amine and gold complex (Ph3PAuNTf2). This methodology provided a facile approach to access the [6,5,6]-tricyclic skeleton in fairly good yield and with perfect enantioselectivities (98% to >99% ee).
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wu
authors.forename: Ming-Li
authors.initials: ML
authors.lastname: Li
authors.forename: Dian-Feng
authors.initials: DF
authors.lastname: Chen
authors.forename: Shu-Sen
authors.initials: SS
authors.lastname: Chen
mesh_terms: D000588:Amines / Q000737:chemistry*; D002074:Butanones / Q000737:chemistry*; D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D008301:Maleimides / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D002074:Butanones; D002930:Cinchona Alkaloids; D008301:Maleimides; D008670:Metals; D011083:Polycyclic Compounds; C043592:maleimide; D006046:Gold