title: Hepatitis A infection in patients with chronic viral liver disease: a cross-sectional study in Jahrom, Iran.
abstract: Infection with hepatitis A virus (HAV) in patient with chronic liver disease (CLD; due to hepatitis B or hepatitis C) may cause severe disease and fulminant liver failure. This study aimed to determine the seroprevalence of HAV antibodies in patients infected with HCV or HBV in Iran (Jahrom city). A total of 159 patients with underlying CLD were recruited between September 2012 and February 2013. Serum samples were collected from each patient and tested for anti-HAV using enzyme-linked immunosorbent assay (ELISA). The overall seroprevalence of total anti-HAV was 79·2%. Patients aged 20-30 years had the lowest (28·3%) anti-HAV seropositivity and those aged >50 years had the highest (95%) seropositivity. The overall prevalence of anti-HAV in patients with chronic HCV and HBV infection was 93·7% and 77·1%, respectively. The anti-HAV seropositivity in liver cirrhosis patients was 100% compared to CLD patients. Because of low HAV immunity in younger CLD patients, vaccination against HAV should be considered.
authors.affiliation: Department of Microbiology,Jahrom University of Medical Sciences,Jahrom,Iran.
authors.forename: A
authors.initials: A
authors.lastname: Ahmadi Vasmehjani
authors.affiliation: Department of Microbiology,Jahrom University of Medical Sciences,Jahrom,Iran.
authors.forename: D
authors.initials: D
authors.lastname: Javeshghani
authors.affiliation: Department of Microbiology,Jahrom University of Medical Sciences,Jahrom,Iran.
authors.forename: R
authors.initials: R
authors.lastname: Baharlou
authors.affiliation: Department of Virology,Tehran University of Medical Sciences,Tehran,Iran.
authors.forename: M
authors.initials: M
authors.lastname: Shayestehpour
authors.affiliation: Department of Virology, Faculty of Medical Sciences,Tarbiat Modares University,Tehran,Iran.
authors.forename: S D
authors.initials: SD
authors.lastname: Mousavinasab
authors.affiliation: Department of Microbiology,Jahrom University of Medical Sciences,Jahrom,Iran.
authors.forename: N
authors.initials: N
authors.lastname: Joharinia
authors.affiliation: Department of Molecular Medicine,Zanjan University of Medical Sciences,Zanjan,Iran.
authors.forename: S E
authors.initials: SE
authors.lastname: Enderami
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology*; D035922:Hepatitis A Antibodies / Q000097:blood; D030041:Hepatitis A virus / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D035922:Hepatitis A Antibodies
keywords: ELISA; hepatitis A; hepatitis B; hepatitis C
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