title: Serum interleukin-17 as a diagnostic and prognostic marker for non-small cell lung cancer.
abstract: OBJECTIVE
  The aim of this study was to explore the clinical role of serum interleukin (IL)-17 in patients with non-small-cell lung cancer (NSCLC).
  
  
  METHODS
  Serum specimens from 128 patients with NSCLC and 60 healthy controls were collected. The concentrations of IL-17 were measured using enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Serum IL-17 levels were higher in the NSCLC group in comparison with the control group (p < 0.01). With a cut-off value of 16 pg/ml, IL-17 showed a good diagnostic performance for NSCLC. Multivariate survival analysis indicated that IL-17 was an independent prognostic factor in NSCLC.
  
  
  CONCLUSIONS
  Measurement of IL-17 might be a useful diagnostic and prognostic value for patients with NSCLC.
authors.affiliation: Department of Respiratory Medicine, Nanjing Chest Hospital , Nanjing , China and.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Xu
authors.forename: Keke
authors.initials: K
authors.lastname: Hao
authors.forename: Like
authors.initials: L
authors.lastname: Yu
authors.forename: Xiuwei
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D020381:Interleukin-17; D002097:C-Reactive Protein
keywords: Diagnosis; interleukin-17; non-small cell lung cancer; prognosis