title: Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks.
abstract: MicroRNAs are potent regulators of gene expression and modulate multiple cellular processes including proliferation, differentiation and apoptosis. A number of microRNAs have been shown to be regulated by p53, the most frequently mutated gene in human cancer. It is has been demonstrated that some mutant p53 proteins not only lose tumor suppressor activity, but also acquire novel oncogenic functions that are independent of wild-type p53. In this review, we highlight recent evidences suggesting that some mutant p53 proteins regulate the expression of specific microRNAs to gain oncogenic functions and identify a gene network regulated by the microRNAs downstream of mutant p53.
authors.affiliation: Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Xiao Ling
authors.initials: XL
authors.lastname: Li
authors.affiliation: Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Jones
authors.affiliation: Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Murugan
authors.initials: M
authors.lastname: Subramanian
authors.affiliation: Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: ashish.lal@nih.gov.
authors.forename: Ashish
authors.initials: A
authors.lastname: Lal
mesh_terms: D000818:Animals; D053263:Gene Regulatory Networks; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D016159:Tumor Suppressor Protein p53
keywords: Cancer; Gain-of-function; Invasion; Let-7; Metastasis; Mutant p53; miR-128-2; miR-130b; miR-155; miR-205; miR-223; miR-27a; miRNA; microRNA
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