title: The prelude on novel receptor and ligand targets involved in the treatment of diabetes mellitus.
abstract: Metabolic disorders are a group of disorders, due to the disruption of the normal metabolic process at a cellular level. Diabetes Mellitus and Tyrosinaemia are the majorly reported metabolic disorders. Among them, Diabetes Mellitus is a one of the leading metabolic syndrome, affecting 5 to 7 % of the population worldwide and mainly characterised by elevated levels of glucose and is associated with two types of physiological event disturbances such as impaired insulin secretion and insulin resistance. Up to now, various treatment strategies are like insulin, alphaglucosidase inhibitors, biguanides, incretins were being followed. Concurrently, various novel therapeutic strategies are required to advance the therapy of Diabetes mellitus. For the last few decades, there has been an extensive research in understanding the metabolic pathways involved in Diabetes Mellitus at the cellular level and having the profound knowledge on cell-growth, cell-cycle, and apoptosis at a molecular level provides new targets for the treatment of Diabetes Mellitus. Receptor signalling has been involved in these mechanisms, to translate the information coming from outside. To understand the various receptors involved in these pathways, we must have a sound knowledge on receptors and ligands involved in it. This review mainly summarises the receptors and ligands which are involved the Diabetes Mellitus. Finally, researchers have to develop the alternative chemical moieties that retain their affinity to receptors and efficacy. Diabetes Mellitus being a metabolic disorder due to the glucose surfeit, demands the need for regular exercise along with dietary changes.
authors.affiliation: Shree Dhootapapeshwar Ayurvedic Research Foundation (SDARF), Panvel, Navi Mumbai-410206, Maharastra, India.
authors.forename: Venu Gopal
authors.initials: VG
authors.lastname: Jonnalagadda
authors.affiliation: National Institute of Pharmaceutical Education and Research, Bala Nagar, Hyderabad, Andhra Pradhesh-500037, India.
authors.forename: Allam Venkata Sita
authors.initials: AV
authors.lastname: Ram Raju
authors.affiliation: CSIR-Institute of Genomics and Integrative Biology, Near Jubilee Hall, Mall Road, Delhi-110 007, India.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Pittala
authors.affiliation: Gokula Krishna college of Pharmacy, Sullurpet - 524121, Nellore dist, A.P, India.
authors.forename: Afsar
authors.initials: A
authors.lastname: Shaik
authors.affiliation: National Institute for Research in Reproductive Health, Parel, Mumbai-400012, Maharastra, India.
authors.forename: Nilakash Annaji
authors.initials: NA
authors.lastname: Selkar
keywords: Diabetes Mellitus; Ligands; Receptors; signalling
references.citation: Peptides. 2001 Mar;22(3):429-38
references.pmid: 11287098
references.citation: Cell Death Differ. 2007 Jul;14(7):1315-23
references.pmid: 17396131
references.citation: Lab Invest. 2010 Nov;90(11):1628-36
references.pmid: 20733560
references.citation: Front Endocrinol (Lausanne). 2012 Nov 26;3:143
references.pmid: 23230428
references.citation: J Membr Biol. 2001 Jul 15;182(2):105-12
references.pmid: 11447502
references.citation: J Physiol. 2003 Nov 15;553(Pt 1):137-45
references.pmid: 12963802
references.citation: J Clin Endocrinol Metab. 2012 Apr;97(4):E642-7
references.pmid: 22278421
references.citation: Nat Rev Drug Discov. 2002 Sep;1(9):696-709
references.pmid: 12209150
references.citation: Immunity. 2007 Aug;27(2):321-33
references.pmid: 17707128
references.citation: Diabetes Care. 2004 May;27(5):1047-53
references.pmid: 15111519
references.citation: J Clin Endocrinol Metab. 2001 Mar;86(3):972-9
references.pmid: 11238471
references.citation: J Biol Chem. 2004 Apr 23;279(17):17079-84
references.pmid: 14764599
references.citation: Gut. 1987;28 Suppl:63-9
references.pmid: 2446964
references.citation: Diabetes. 2001 Sep;50(9):2094-9
references.pmid: 11522676
references.citation: J Biol Chem. 2006 Apr 21;281(16):11039-49
references.pmid: 16446356
references.citation: Endocr Rev. 2000 Jun;21(3):215-44
references.pmid: 10857553
references.citation: Mol Cell Biochem. 1998 May;182(1-2):3-11
references.pmid: 9609109
references.citation: Diabetes Care. 2006 Mar;29(3):650-6
references.pmid: 16505521
references.citation: PLoS One. 2012;7(7):e40584
references.pmid: 22848385
references.citation: Gut. 2008 Nov;57(11):1531-8
references.pmid: 18676419
references.citation: Int J Obes Relat Metab Disord. 2004 Aug;28(8):1004-10
references.pmid: 15211367
references.citation: Diabetes. 2008 Jun;57(6):1629-37
references.pmid: 18319304
references.citation: J Leukoc Biol. 2009 Sep;86(3):655-62
references.pmid: 19564572
references.citation: Endocrinology. 2002 Oct;143(10):3717-26
references.pmid: 12239081
references.citation: J Clin Invest. 2006 Apr;116(4):1102-9
references.pmid: 16557297
references.citation: J Endocrinol. 2006 Sep;190(3):703-10
references.pmid: 17003271
references.citation: J Immunol. 2009 Aug 15;183(4):2785-92
references.pmid: 19635908
references.citation: Gastroenterology. 1988 Jan;94(1):109-13
references.pmid: 3335282
references.citation: EMBO Rep. 2009 Aug;10(8):873-80
references.pmid: 19575010
references.citation: Obes Res. 2005 Jan;13(1):179-85
references.pmid: 15761178
references.citation: Med Microbiol Immunol. 2008 Mar;197(1):1-8
references.pmid: 17638015
references.citation: Autoimmunity. 2006 Mar;39(2):143-51
references.pmid: 16698671
references.citation: EMBO J. 1997 Sep 15;16(18):5572-81
references.pmid: 9312016
references.citation: J Leukoc Biol. 2004 Sep;76(3):514-9
references.pmid: 15178705
references.citation: Lancet. 2003 Jan 18;361(9353):226-8
references.pmid: 12547549
references.citation: J Epidemiol Community Health. 2009 Apr;63(4):332-6
references.pmid: 19240084
references.citation: Endocrinology. 2011 Jul;152(7):2568-79
references.pmid: 21521748
references.citation: Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2020-30
references.pmid: 16037564
references.citation: World J Diabetes. 2010 Jul 15;1(3):68-75
references.pmid: 21537430
references.citation: Endocr Rev. 2011 Feb;32(1):3-30
references.pmid: 20729338
references.citation: J Nanobiotechnology. 2010 Jul 14;8:16
references.pmid: 20630072
references.citation: FASEB J. 2001 Jan;15(1):215-220
references.pmid: 11149909
references.citation: Diabetes. 2001 May;50(5):1083-92
references.pmid: 11334412
references.citation: J Pharmacol Exp Ther. 2009 Jan;328(1):174-82
references.pmid: 18832649
references.citation: PPAR Res. 2007;2007:93416
references.pmid: 17389773
references.citation: Diabetes. 2002 Dec;51(12):3420-7
references.pmid: 12453895
references.citation: J Biol Chem. 2002 Sep 27;277(39):36740-7
references.pmid: 12101187
references.citation: Metabolism. 2000 Aug;49(8):990-5
references.pmid: 10954015
references.citation: Eur J Pharm Sci. 2011 Oct 9;44(3):207-17
references.pmid: 21839831
references.citation: J Biol Chem. 2007 May 25;282(21):15541-9
references.pmid: 17430902
references.citation: Nat Clin Pract Endocrinol Metab. 2008 May;4(5):285-93
references.pmid: 18332897
references.citation: J Clin Invest. 1989 May;83(5):1717-23
references.pmid: 2651479
references.citation: Mol Biol Cell. 2008 Jan;19(1):198-206
references.pmid: 17978097
references.citation: J Biol Chem. 1995 Nov 10;270(45):26746-9
references.pmid: 7592907
references.citation: J Neurosci Res. 1991 Oct;30(2):398-413
references.pmid: 1686786
references.citation: Ann Intern Med. 1994 Sep 15;121(6):416-22
references.pmid: 8053615
references.citation: J Biol Chem. 2004 May 28;279(22):23158-65
references.pmid: 15047713
references.citation: Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14751-6
references.pmid: 9843961
references.citation: Am J Physiol. 1983 Jul;245(1):G99-105
references.pmid: 6191579
references.citation: Endocr Rev. 2001 Oct;22(5):565-604
references.pmid: 11588141
references.citation: Biochem Biophys Res Commun. 2006 Aug 4;346(3):739-45
references.pmid: 16781673
references.citation: Mol Cancer Ther. 2010 Aug;9(8):2389-98
references.pmid: 20663927
references.citation: Br J Nutr. 2003 Jan;89(1):3-9
references.pmid: 12568659
references.citation: Diabetes. 2004 Feb;53 Suppl 1:S60-5
references.pmid: 14749267
references.citation: J Clin Invest. 2000 Aug;106(4):453-8
references.pmid: 10953019
references.citation: Diabetes Res Clin Pract. 2010 Jan;87(1):4-14
references.pmid: 19896746
references.citation: Pancreas. 1996 Jan;12(1):48-57
references.pmid: 8927619
references.citation: Biochem Biophys Res Commun. 1999 Nov;265(1):265-71
references.pmid: 10548525
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21181-6
references.pmid: 21078968
references.citation: Int J Mol Sci. 2012 Oct 03;13(10):12629-55
references.pmid: 23202918
references.citation: Jpn J Pharmacol. 2002 Jul;89(3):290-5
references.pmid: 12184735
references.citation: Br J Pharmacol. 2007 Nov;152(5):576-82
references.pmid: 17704824
references.citation: J Mol Med (Berl). 2008 Feb;86(2):211-20
references.pmid: 17924084
references.citation: Diabetes Metab Res Rev. 2010 Jan;26(1):13-6
references.pmid: 19943320
references.citation: Curr Opin Nephrol Hypertens. 2010 Sep;19(5):425-31
references.pmid: 20539226
references.citation: Cell. 1984 Mar;36(3):577-9
references.pmid: 6321035
references.citation: Clin Sci (Lond). 2012 Mar;122(5):203-14
references.pmid: 22070434
references.citation: Biochem J. 1998 Apr 1;331 ( Pt 1):129-35
references.pmid: 9512470
references.citation: Vascul Pharmacol. 2002 Feb;38(2):73-80
references.pmid: 12379953
references.citation: Biochem Soc Trans. 2008 Jun;36(Pt 3):280-5
references.pmid: 18481942
references.citation: Curr Protein Pept Sci. 2009 Feb;10(1):56-74
references.pmid: 19275673
references.citation: J Cell Biol. 2002 Jul 22;158(2):227-33
references.pmid: 12119361
references.citation: Am J Pathol. 2012 Feb;180(2):432-42
references.pmid: 22155112
references.citation: Biochim Biophys Acta. 2010 Mar;1802(3):363-72
references.pmid: 20060466
references.citation: Nature. 1994 Dec 22-29;372(6508):746-54
references.pmid: 7997262
references.citation: Adv Immunol. 2006;91:159-73
references.pmid: 16938540
references.citation: Eur Neuropsychopharmacol. 2012 May;22(5):364-73
references.pmid: 21982116