title: Genome-wide association for growth traits in Canchim beef cattle.
abstract: Studies are being conducted on the applicability of genomic data to improve the accuracy of the selection process in livestock, and genome-wide association studies (GWAS) provide valuable information to enhance the understanding on the genetics of complex traits. The aim of this study was to identify genomic regions and genes that play roles in birth weight (BW), weaning weight adjusted for 210 days of age (WW), and long-yearling weight adjusted for 420 days of age (LYW) in Canchim cattle. GWAS were performed by means of the Generalized Quasi-Likelihood Score (GQLS) method using genotypes from the BovineHD BeadChip and estimated breeding values for BW, WW, and LYW. Data consisted of 285 animals from the Canchim breed and 114 from the MA genetic group (derived from crossings between Charolais sires and ½ Canchim + ½ Zebu dams). After applying a false discovery rate correction at a 10% significance level, a total of 4, 12, and 10 SNPs were significantly associated with BW, WW, and LYW, respectively. These SNPs were surveyed to their corresponding genes or to surrounding genes within a distance of 250 kb. The genes DPP6 (dipeptidyl-peptidase 6) and CLEC3B (C-type lectin domain family 3 member B) were highlighted, considering its functions on the development of the brain and skeletal system, respectively. The GQLS method identified regions on chromosome associated with birth weight, weaning weight, and long-yearling weight in Canchim and MA animals. New candidate regions for body weight traits were detected and some of them have interesting biological functions, of which most have not been previously reported. The observation of QTL reports for body weight traits, covering areas surrounding the genes (SNPs) herein identified provides more evidence for these associations. Future studies targeting these areas could provide further knowledge to uncover the genetic architecture underlying growth traits in Canchim cattle.
authors.affiliation: Departamento de Ciências Exatas, UNESP - Univ Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, São Paulo, Brazil.
authors.forename: Marcos E
authors.initials: ME
authors.lastname: Buzanskas
authors.affiliation: Department of Animal and Poultry Science, University of Guelph, Centre for Genetic Improvement of Livestock (CGIL), Guelph, Ontario, Canada.
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Grossi
authors.affiliation: Department of Animal and Poultry Science, University of Guelph, Centre for Genetic Improvement of Livestock (CGIL), Guelph, Ontario, Canada; Beef Improvement Opportunities (BIO), Guelph, Ontario, Canada.
authors.forename: Ricardo V
authors.initials: RV
authors.lastname: Ventura
authors.affiliation: Department of Animal and Poultry Science, University of Guelph, Centre for Genetic Improvement of Livestock (CGIL), Guelph, Ontario, Canada.
authors.forename: Flávio S
authors.initials: FS
authors.lastname: Schenkel
authors.affiliation: Department of Animal and Poultry Science, University of Guelph, Centre for Genetic Improvement of Livestock (CGIL), Guelph, Ontario, Canada; The Semex Alliance, Guelph, Ontario, Canada.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Sargolzaei
authors.affiliation: Department of Animal Science, Federal University of Lavras (UFLA), Lavras, Minas Gerais, Brazil.
authors.forename: Sarah L C
authors.initials: SL
authors.lastname: Meirelles
authors.affiliation: Department of Genetics and Evolution, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil.
authors.forename: Fabiana B
authors.initials: FB
authors.lastname: Mokry
authors.affiliation: Embrapa Agricultural Informatics, Campinas, São Paulo, Brazil.
authors.forename: Roberto H
authors.initials: RH
authors.lastname: Higa
authors.affiliation: Embrapa Southeast Livestock, São Carlos, São Paulo, Brazil.
authors.forename: Maurício A
authors.initials: MA
authors.lastname: Mudadu
authors.affiliation: Embrapa Dairy Cattle, Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Marcos V G Barbosa
authors.initials: MV
authors.lastname: da Silva
authors.affiliation: Embrapa Southeast Livestock, São Carlos, São Paulo, Brazil.
authors.forename: Simone C M
authors.initials: SC
authors.lastname: Niciura
authors.affiliation: Embrapa Beef Cattle, Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Roberto A A
authors.initials: RA
authors.lastname: Torres
authors.affiliation: Embrapa Southeast Livestock, São Carlos, São Paulo, Brazil.
authors.forename: Maurício M
authors.initials: MM
authors.lastname: Alencar
authors.affiliation: Embrapa Southeast Livestock, São Carlos, São Paulo, Brazil.
authors.forename: Luciana C A
authors.initials: LC
authors.lastname: Regitano
authors.affiliation: Departamento de Ciências Exatas, UNESP - Univ Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, São Paulo, Brazil.
authors.forename: Danísio P
authors.initials: DP
authors.lastname: Munari
mesh_terms: D000818:Animals; D001724:Birth Weight / Q000235:genetics; D001938:Brazil; D002417:Cattle / Q000235:genetics* / Q000254:growth & development*; D033481:Chromosomes, Mammalian / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D016013:Likelihood Functions; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D019655:Quantitative Trait, Heritable; D014886:Weaning
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