title: NG2 cells (polydendrocytes): listeners to the neural network with diverse properties.
abstract: NG2 cells (polydendrocytes) are the fourth major non-neuronal cell type in the central nervous system parenchyma. They exhibit diverse properties, ranging from their well-established role as oligodendrocyte precursors to their ability to respond to neurotransmitters released by synaptic and non-synaptic mechanisms. The functional diversity of NG2 cells has prompted the question of whether they represent a single cellular entity or multiple distinct cell populations. This review first summarizes recent findings on the nature and mechanism underlying the diversity of NG2 cells with regard to their proliferative and differentiation behavior. This will be followed by a synopsis of observations on how their microenvironment, particularly neuronal activity, influences their dynamic behavior, and how these changes in NG2 cells could in turn influence neural function and animal behavior.
authors.affiliation: Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Hill
authors.forename: Akiko
authors.initials: A
authors.lastname: Nishiyama
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000502:physiology; D006801:Humans; D055495:Neurogenesis / Q000502:physiology; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000502:physiology
keywords: PDGF; demyelination; myelin; oligodendrocyte; oligodendrocyte precursor cell; plasticity; polydendrocyte; white matter
references.citation: Nat Neurosci. 2008 Dec;11(12):1392-401
references.pmid: 18849983
references.citation: Nat Methods. 2012 Sep;9(9):917-22
references.pmid: 22796663
references.citation: Development. 2011 Feb;138(4):745-53
references.pmid: 21266410
references.citation: Nat Neurosci. 2013 Aug;16(8):1032-41
references.pmid: 23852113
references.citation: J Neurosci. 2013 Sep 4;33(36):14558-66
references.pmid: 24005306
references.citation: Nature. 2010 Jun 24;465(7301):1070-4
references.pmid: 20543823
references.citation: J Neurosci. 2011 Jan 19;31(3):843-50
references.pmid: 21248107
references.citation: J Neurosci. 1996 Apr 15;16(8):2659-70
references.pmid: 8786442
references.citation: Cell Death Dis. 2013 Mar 14;4:e537
references.pmid: 23492768
references.citation: Brain. 2011 Jul;134(Pt 7):1914-24
references.pmid: 21653539
references.citation: Nat Neurosci. 2013 Oct;16(10):1370-2
references.pmid: 23995069
references.citation: Cereb Cortex. 2015 Apr;25(4):1114-23
references.pmid: 24217990
references.citation: Neuroscience. 2014 Sep 12;276:135-47
references.pmid: 24291730
references.citation: Glia. 2013 May;61(5):732-49
references.pmid: 23440860
references.citation: Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10032-7
references.pmid: 10944195
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14662-7
references.pmid: 18787118
references.citation: Glia. 2005 Mar;49(4):467-79
references.pmid: 15578662
references.citation: J Neurosci. 2014 Feb 5;34(6):2305-13
references.pmid: 24501369
references.citation: Development. 1999 Feb;126(3):457-67
references.pmid: 9876175
references.citation: Cell Mol Life Sci. 2014 Mar;71(6):1055-66
references.pmid: 24132511
references.citation: Science. 2012 Sep 14;337(6100):1357-60
references.pmid: 22984073
references.citation: Brain. 1999 Jan;122 ( Pt 1):17-26
references.pmid: 10050891
references.citation: Trends Neurosci. 2008 Jul;31(7):361-70
references.pmid: 18538868
references.citation: Nat Neurosci. 2006 Feb;9(2):173-9
references.pmid: 16388308
references.citation: J Neurosci. 2002 Dec 1;22(23):10333-45
references.pmid: 12451133
references.citation: Neuroscience. 2003;116(4):1053-62
references.pmid: 12617946
references.citation: Nature. 1983 Jun 2-8;303(5916):390-6
references.pmid: 6304520
references.citation: Brain Pathol. 2007 Apr;17(2):129-38
references.pmid: 17388943
references.citation: J Neurosci. 2001 Aug 1;21(15):5429-38
references.pmid: 11466414
references.citation: Nat Cell Biol. 2013 Jun;15(6):602-13
references.pmid: 23644466
references.citation: Nature. 2010 Nov 11;468(7321):214-22
references.pmid: 21068830
references.citation: Glia. 2010 Jan 1;58(1):66-79
references.pmid: 19533604
references.citation: Science. 2011 Sep 16;333(6049):1647-51
references.pmid: 21817014
references.citation: J Neurosci. 2012 May 9;32(19):6631-41
references.pmid: 22573685
references.citation: Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9887-92
references.pmid: 8790426
references.citation: J Neurosci. 2012 Jun 27;32(26):8855-64
references.pmid: 22745486
references.citation: Nat Neurosci. 2009 Jul;12(7):829-38
references.pmid: 19503085
references.citation: Glia. 2008 May;56(7):734-49
references.pmid: 18293404
references.citation: Cell Death Differ. 2012 Apr;19(4):562-72
references.pmid: 21959935
references.citation: J Neurosci. 2010 Jun 16;30(24):8320-31
references.pmid: 20554883
references.citation: J Neurosci. 2011 May 4;31(18):6809-6819
references.pmid: 21543611
references.citation: Nature. 2009 Oct 15;461(7266):983-6
references.pmid: 19829380
references.citation: Nat Neurosci. 2013 Sep;16(9):1211-1218
references.pmid: 23872599
references.citation: Glia. 2011 May;59(5):800-9
references.pmid: 21351161
references.citation: Nature. 1993 Jan 21;361(6409):258-60
references.pmid: 8093806
references.citation: Nat Rev Neurosci. 2009 Jan;10(1):9-22
references.pmid: 19096367
references.citation: Neuron Glia Biol. 2008 Feb;4(1):19-26
references.pmid: 19006598
references.citation: Nat Neurosci. 2013 Sep;16(9):1191-1198
references.pmid: 23955559
references.citation: Cell Stem Cell. 2013 Feb 7;12(2):252-64
references.pmid: 23395447
references.citation: Science. 2010 Nov 5;330(6005):768-9
references.pmid: 21051624
references.citation: Cell Stem Cell. 2011 Jan 7;8(1):59-71
references.pmid: 21211782
references.citation: Development. 1998 Aug;125(15):2901-14
references.pmid: 9655812
references.citation: Neuron. 2010 Nov 18;68(4):668-81
references.pmid: 21092857
references.citation: Cell Stem Cell. 2012 Jan 6;10(1):96-103
references.pmid: 22226359
references.citation: EMBO J. 2002 Apr 15;21(8):1957-66
references.pmid: 11953315
references.citation: Nat Neurosci. 2012 Mar 18;15(4):528-36
references.pmid: 22426254
references.citation: EMBO J. 1997 Jan 15;16(2):306-17
references.pmid: 9029151
references.citation: Aging Cell. 2009 Apr;8(2):201-13
references.pmid: 19338498
references.citation: Nat Neurosci. 2013 Jun;16(6):668-76
references.pmid: 23624515
references.citation: J Neurosci. 1987 Sep;7(9):2737-44
references.pmid: 3305800
references.citation: Science. 2000 Sep 8;289(5485):1754-7
references.pmid: 10976069
references.citation: Nat Neurosci. 2012 Dec;15(12):1621-3
references.pmid: 23143512
references.citation: J Neurosci Res. 1999 Aug 15;57(4):435-46
references.pmid: 10440893
references.citation: Nature. 1988 Jun 9;333(6173):560-2
references.pmid: 3287176
references.citation: Nat Neurosci. 2008 Sep;11(9):1024-34
references.pmid: 19160500
references.citation: Dev Neurosci. 2001;23(4-5):356-63
references.pmid: 11756751
references.citation: Neurosci Bull. 2013 Apr;29(2):165-76
references.pmid: 23516142
references.citation: J Physiol. 2004 Nov 15;561(Pt 1):109-22
references.pmid: 15358811
references.citation: J Neurosci. 2007 Oct 17;27(42):11354-65
references.pmid: 17942730
references.citation: Glia. 1998 Feb;22(2):161-70
references.pmid: 9537836
references.citation: Mol Cell Neurosci. 2003 Oct;24(2):476-88
references.pmid: 14572468
references.citation: J Neurosci Res. 2000 Nov 1;62(3):336-45
references.pmid: 11054802
references.citation: J Neurosci. 2011 Aug 31;31(35):12650-62
references.pmid: 21880926
references.citation: Neurosci Lett. 2010 Jul 26;479(2):128-33
references.pmid: 20493923
references.citation: Neurobiol Aging. 2008 Mar;29(3):452-63
references.pmid: 17182153
references.citation: J Neurosci. 1986 Nov;6(11):3133-43
references.pmid: 3490547
references.citation: Neuroscientist. 2011 Apr;17(2):185-96
references.pmid: 21403182
references.citation: Development. 2008 Jan;135(1):145-57
references.pmid: 18045844
references.citation: Nat Neurosci. 2012 Sep;15(9):1192-4
references.pmid: 22885848
references.citation: Cell. 1988 Apr 22;53(2):309-19
references.pmid: 2834067
references.citation: Neuron. 1993 Feb;10(2):201-12
references.pmid: 8439409
references.citation: Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2350-5
references.pmid: 11854528
references.citation: J Neurocytol. 1999 Apr-May;28(4-5):365-81
references.pmid: 10739577
references.citation: J Neurosci. 2009 Jun 3;29(22):7256-70
references.pmid: 19494148
references.citation: Neuron. 2011 May 26;70(4):661-73
references.pmid: 21609823
references.citation: Nat Med. 2004 Jan;10(1):93-7
references.pmid: 14702638
references.citation: Neuron. 2002 Dec 5;36(5):855-68
references.pmid: 12467589
references.citation: Brain Res Rev. 2010 May;63(1-2):130-7
references.pmid: 20018210
references.citation: Cell Death Dis. 2012 Feb 02;3:e268
references.pmid: 22297298
references.citation: J Neurosci. 2000 Apr 1;20(7):2609-17
references.pmid: 10729341
references.citation: J Neurosci. 1998 Dec 15;18(24):10457-63
references.pmid: 9852583
references.citation: J Comp Neurol. 1998 Sep 14;399(1):94-100
references.pmid: 9725703
references.citation: Neuron. 2013 Oct 2;80(1):12-34
references.pmid: 24094100
references.citation: Stem Cell Rev Rep. 2009 Sep;5(3):231-46
references.pmid: 19562527
references.citation: Glia. 2004 Dec;48(4):337-45
references.pmid: 15390108
references.citation: Nature. 2000 May 11;405(6783):187-91
references.pmid: 10821275
references.citation: PLoS One. 2011 Mar 24;6(3):e17575
references.pmid: 21455301
references.citation: Nature. 2010 Nov 11;468(7321):244-52
references.pmid: 21068833
references.citation: Nat Neurosci. 2007 Mar;10(3):311-20
references.pmid: 17293860
references.citation: J Neurosci Res. 2009 Nov 15;87(15):3259-66
references.pmid: 19021296
references.citation: Neuron. 2006 Mar 16;49(6):823-32
references.pmid: 16543131
references.citation: Cell. 2013 Jan 17;152(1-2):97-108
references.pmid: 23332748
references.citation: Nat Neurosci. 2013 May;16(5):580-6
references.pmid: 23542688
references.citation: N Engl J Med. 2011 Dec 8;365(23):2188-97
references.pmid: 22150037
references.citation: J Neurosci Res. 1996 Feb 01;43(3):299-314
references.pmid: 8714519
references.citation: J Neurosci. 2008 Oct 8;28(41):10434-42
references.pmid: 18842903
references.citation: Nat Rev Neurosci. 2003 May;4(5):399-415
references.pmid: 12728267
references.citation: Dev Biol. 2002 May 15;245(2):362-75
references.pmid: 11977987
references.citation: Nat Cell Biol. 2002 Nov;4(11):833-41
references.pmid: 12379866
references.citation: Nat Neurosci. 2009 Nov;12(11):1370-1
references.pmid: 19820707
references.citation: Neuron. 1998 May;20(5):869-82
references.pmid: 9620692
references.citation: J Neurosci. 2010 Mar 10;30(10):3600-11
references.pmid: 20219994
references.citation: J Neurosci. 1998 Nov 15;18(22):9303-11
references.pmid: 9801369
references.citation: Nat Rev Neurosci. 2002 Sep;3(9):705-14
references.pmid: 12209119
references.citation: J Neurophysiol. 2006 Mar;95(3):1843-52
references.pmid: 16306174
references.citation: J Neurosci. 2002 Apr 1;22(7):2451-9
references.pmid: 11923409
references.citation: Science. 2006 Jun 9;312(5779):1533-7
references.pmid: 16763153
references.citation: Development. 1989 Feb;105(2):387-400
references.pmid: 2680425
references.citation: Neuron. 2013 Mar 6;77(5):873-85
references.pmid: 23473318
references.citation: Neuron Glia Biol. 2009 Nov;5(3-4):57-67
references.pmid: 20346197
references.citation: Glia. 2011 Jun;59(6):869-81
references.pmid: 21446038
references.citation: Int J Dev Neurosci. 2001 Jul;19(4):379-85
references.pmid: 11378298
references.citation: Glia. 2004 Oct;48(1):51-63
references.pmid: 15326615
references.citation: Nat Neurosci. 2005 Sep;8(9):1148-50
references.pmid: 16116456
references.citation: J Neurosci. 1987 Sep;7(9):2721-31
references.pmid: 3305799
references.citation: Nat Neurosci. 2006 Dec;9(12):1506-11
references.pmid: 17099706
references.citation: J Cell Biol. 2005 May 23;169(4):577-89
references.pmid: 15897262
references.citation: Development. 2012 Jul;139(13):2299-307
references.pmid: 22627280
references.citation: Cell Cycle. 2009 Nov 1;8(21):3527-36
references.pmid: 19823012
references.citation: Mol Cell Neurosci. 2011 Apr;46(4):689-98
references.pmid: 21292011
references.citation: Nat Rev Neurosci. 2004 May;5(5):409-19
references.pmid: 15100723
references.citation: Nature. 1988 Jun 9;333(6173):562-5
references.pmid: 3287177
references.citation: Neuron. 1990 Oct;5(4):527-44
references.pmid: 1698397
references.citation: Nat Neurosci. 2007 Mar;10(3):321-30
references.pmid: 17293857
references.citation: Genes Dev. 2008 May 15;22(10):1276-312
references.pmid: 18483217
references.citation: Neurosci Bull. 2013 Apr;29(2):155-64
references.pmid: 23456566
references.citation: J Neurosci Res. 2000 Sep 1;61(5):471-9
references.pmid: 10956416
references.citation: Development. 1992 Jun;115(2):535-51
references.pmid: 1425339