title: [Oncolytic properties of some orthopoxviruses, adenoviruses and parvoviruses in human glioma cells].
abstract: Currently one of the most promising approaches in development of cancer virotherapy is based on the ability of oncolytic viruses to selective infection and lysis of tumor cells.
  
  
  OBJECTIVE
  The goal of the study was to identify and evaluate perspective oncolytic viruses capable of selectively destroying human glioma cells.
  
  
  METHODS
  Original GB2m, GA14m and GB22m glioma cell cultures derived from patients were used for evaluating in vitro oncolytic activity of some typical orthopoxviruses, adenoviruses and parvoviruses.
  
  
  RESULTS
  The oncolytic activity in the human glioma cell models was confirmed for LIVP and WR strains of vaccinia virus, Adel2 and Ad2del strains with deletions within E1B/55K gene and derived from human adenoviruses type 2 and 5, respectively.
  
  
  CONCLUSIONS
  We consider these oncolytic viruses as promising agents for the treatment of human malignant glioma.
authors.forename: I A
authors.initials: IA
authors.lastname: Razumov
authors.forename: V A
authors.initials: VA
authors.lastname: Sviatchenko
authors.forename: E V
authors.initials: EV
authors.lastname: Protopopova
authors.forename: G V
authors.initials: GV
authors.lastname: Kochneva
authors.forename: N N
authors.initials: NN
authors.lastname: Kiselev
authors.forename: N V
authors.initials: NV
authors.lastname: Gubanova
authors.forename: A G
authors.initials: AG
authors.lastname: Shilov
authors.forename: V A
authors.initials: VA
authors.lastname: Mordvinov
authors.forename: S V
authors.initials: SV
authors.lastname: Netesov
authors.forename: P M
authors.initials: PM
authors.lastname: Chumakov
authors.forename: V B
authors.initials: VB
authors.lastname: Loktev
mesh_terms: D000256:Adenoviridae / Q000502:physiology; D018929:Cell Culture Techniques; D005910:Glioma / Q000628:therapy / Q000821:virology; D006801:Humans; D050130:Oncolytic Virotherapy / Q000379:methods*; D050504:Oncolytic Viruses / Q000502:physiology*; D018155:Orthopoxvirus / Q000502:physiology; D017992:Parvovirus / Q000502:physiology; D014407:Tumor Cells, Cultured / Q000821:virology; D018406:Virus Physiological Phenomena