title: Diterpenoids and phenylethanoid glycosides from the roots of Clerodendrum bungei and their inhibitory effects against angiotensin converting enzyme and α-glucosidase.
abstract: Abietane derivatives, bungnates A, B, 15-dehydrocyrtophyllone A and 15-dehydro-17-hydroxycyrtophyllone A, and two phenylethanoid glycosides, bunginoside A and 3″,4″-di-O-acetylmartynoside, together with nine known abietane derivatives and fourteen known phenylethanoid glycosides, were isolated from dried roots of Clerodendrum bungei. Their structures were determined on the basis of detailed spectroscopic analyses and acidic hydrolysis. The absolute configuration of bunginoside A was established from analysis of CD data. Selected compounds were evaluated for inhibitory effects against angiotensin converting enzyme (ACE) and α-glucosidase. 15-Dehydrocyrtophyllone A showed an ACE inhibitory effect, and verbascoside, leucosceptoside A and isoacteoside exhibited strong inhibitory capacity against α-glucosidase.
authors.affiliation: The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Hu
authors.affiliation: The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Li
authors.affiliation: The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China.
authors.forename: Ying-Bo
authors.initials: YB
authors.lastname: Yang
authors.affiliation: Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Wu
authors.affiliation: The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China.
authors.forename: Gui-Xin
authors.initials: GX
authors.lastname: Chou
authors.affiliation: The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China. Electronic address: ztwang@shutcm.edu.cn.
authors.forename: Zheng-Tao
authors.initials: ZT
authors.lastname: Wang
mesh_terms: D032409:Clerodendrum / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D018517:Plant Roots / Q000737:chemistry*; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D004224:Diterpenes; D006027:Glycosides; D000520:alpha-Glucosidases; D007703:Peptidyl-Dipeptidase A
keywords: Angiotensin converting enzyme; Chemistry of Chinese medicines; Clerodendrum bungei; Diterpenoid; Lamiaceae; Phenylethanoid glycoside; α-Glucosidase