title: TERT attenuated ER stress-induced cell death.
abstract: Tumor cells are frequently encountered in nutrient-deprived areas, though the mechanisms underlying their survival are unclear. In the present study, we found that depriving cells of glucose caused endoplasmic reticulum stress (ER stress) in a breast cancer cells line, MCF-7, and that specific activation of ER stress increased telomerase reverse transcriptase (TERT) expression. TERT expression would function in counteracting against the stress because over-expression of TERT diminished ER stress-induced cell death. Therefore, the results provide evidence for the underlying mechanisms of tumor progression in stressed conditions, highlighting that ER stress induces TERT expression to withstand environmental stress, a mechanism which we termed the "ER stress-TERT axis".
authors.affiliation: Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. Electronic address: toruh@hiroshima-u.ac.jp.
authors.forename: Toru
authors.initials: T
authors.lastname: Hosoi
authors.affiliation: Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Inoue
authors.affiliation: Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Nakatsu
authors.affiliation: Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Matsushima
authors.affiliation: Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Kiyose
authors.affiliation: Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Shimamoto
authors.affiliation: Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Tahara
authors.affiliation: Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. Electronic address: ozawak@hiroshima-u.ac.jp.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Ozawa
mesh_terms: D017209:Apoptosis; D018450:Disease Progression; D059865:Endoplasmic Reticulum Stress; D005947:Glucose / Q000172:deficiency; D006801:Humans; D061986:MCF-7 Cells; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology*; D019098:Telomerase / Q000502:physiology*
chemical_list: D019098:Telomerase; D005947:Glucose
keywords: Cancer; Endoplasmic reticulum stress; Telomerase; Telomerase reverse transcriptase