title: Estrogen Deficiency and the Origin of Obesity during Menopause.
abstract: Sex hormones strongly influence body fat distribution and adipocyte differentiation. Estrogens and testosterone differentially affect adipocyte physiology, but the importance of estrogens in the development of metabolic diseases during menopause is disputed. Estrogens and estrogen receptors regulate various aspects of glucose and lipid metabolism. Disturbances of this metabolic signal lead to the development of metabolic syndrome and a higher cardiovascular risk in women. The absence of estrogens is a clue factor in the onset of cardiovascular disease during the menopausal period, which is characterized by lipid profile variations and predominant abdominal fat accumulation. However, influence of the absence of these hormones and its relationship to higher obesity in women during menopause are not clear. This systematic review discusses of the role of estrogens and estrogen receptors in adipocyte differentiation, and its control by the central nervous systemn and the possible role of estrogen-like compounds and endocrine disruptors chemicals are discussed. Finally, the interaction between the decrease in estrogen secretion and the prevalence of obesity in menopausal women is examined. We will consider if the absence of estrogens have a significant effect of obesity in menopausal women.
authors.affiliation: Biomedical Research Center, Universidad de La Sabana (CIBUS), km 7, Autopista Norte de Bogota, Chia, Colombia ; Fundacion Cardio-Infantil Instituto de Cardiologia, Bogota, Colombia.
authors.forename: Fernando
authors.initials: F
authors.lastname: Lizcano
authors.affiliation: Biomedical Research Center, Universidad de La Sabana (CIBUS), km 7, Autopista Norte de Bogota, Chia, Colombia.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Guzmán
mesh_terms: D054392:Adipokines / Q000378:metabolism; D002490:Central Nervous System / Q000502:physiology; D004958:Estradiol / Q000378:metabolism; D004967:Estrogens / Q000172:deficiency* / Q000378:metabolism; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008593:Menopause; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D050177:Overweight; D011960:Receptors, Estrogen / Q000378:metabolism
chemical_list: D054392:Adipokines; D004967:Estrogens; D011960:Receptors, Estrogen; D004958:Estradiol
references.citation: Mol Endocrinol. 2012 Dec;26(12):1957-60
references.pmid: 23051593
references.citation: Diabetes. 2003 Feb;52(2):268-76
references.pmid: 12540596
references.citation: Steroids. 2014 Mar;81:64-9
references.pmid: 24252382
references.citation: Am J Clin Nutr. 2005 Mar;81(3):714-21
references.pmid: 15755843
references.citation: Cell Res. 2010 Apr;20(4):434-44
references.pmid: 20101261
references.citation: J Nutr Health Aging. 2002;6(2):123-6
references.pmid: 12166365
references.citation: Biogerontology. 2013 Aug;14(4):383-94
references.pmid: 23666345
references.citation: Pharmacol Rev. 2010 Jun;62(2):237-64
references.pmid: 20392806
references.citation: Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E124-33
references.pmid: 19366879
references.citation: Eur J Pharmacol. 2011 Jun 11;660(1):181-7
references.pmid: 21211522
references.citation: Obes Rev. 2004 Aug;5(3):153-65
references.pmid: 15245384
references.citation: Fertil Steril. 2007 Jul;88(1):100-6
references.pmid: 17408628
references.citation: Mol Pharmacol. 2005 Jan;67(1):105-13
references.pmid: 15496504
references.citation: Am J Physiol Endocrinol Metab. 2001 Mar;280(3):E496-501
references.pmid: 11171605
references.citation: Biol Reprod. 2007 Oct;77(4):734-42
references.pmid: 17596564
references.citation: Curr Opin Clin Nutr Metab Care. 2012 Jul;15(4):350-6
references.pmid: 22617561
references.citation: Menopause. 2002 Mar-Apr;9(2):117-21
references.pmid: 11875330
references.citation: JAMA. 2010 Jan 20;303(3):235-41
references.pmid: 20071471
references.citation: Fertil Steril. 2006 Aug;86(2):480-3
references.pmid: 16806211
references.citation: J Am Geriatr Soc. 2005 Nov;53(11):1973-7
references.pmid: 16274381
references.citation: Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12729-34
references.pmid: 11070086
references.citation: Steroids. 2012 May;77(6):659-65
references.pmid: 22402114
references.citation: Endocrinol Metab Clin North Am. 2003 Dec;32(4):761-86
references.pmid: 14711061
references.citation: J Mol Endocrinol. 2008 Nov;41(5):263-75
references.pmid: 18772268
references.citation: Nature. 1999 Dec 9;402(6762):656-60
references.pmid: 10604470
references.citation: Diabetes. 2012 Jun;61(6):1353-4
references.pmid: 22618773
references.citation: Nutr Neurosci. 2004 Apr;7(2):67-74
references.pmid: 15279492
references.citation: Horm Metab Res. 2002 Nov-Dec;34(11-12):758-63
references.pmid: 12660895
references.citation: Biochem Biophys Res Commun. 2001 Oct 19;288(1):191-7
references.pmid: 11594772
references.citation: Biochim Biophys Acta. 1992 Feb 3;1133(3):301-6
references.pmid: 1531302
references.citation: Endocr Rev. 2012 Apr;33(2):271-99
references.pmid: 22433123
references.citation: Br J Pharmacol. 2004 Jan;141(2):209-14
references.pmid: 14707028
references.citation: Cell Metab. 2011 Oct 5;14(4):435-6
references.pmid: 21982701
references.citation: Nutr Metab Cardiovasc Dis. 2013 May;23(5):432-42
references.pmid: 22209742
references.citation: Curr Opin Clin Nutr Metab Care. 2012 Jul;15(4):342-9
references.pmid: 22617562
references.citation: J Pharmacol Exp Ther. 2008 Jun;325(3):782-90
references.pmid: 18354059
references.citation: J Endocrinol. 2012 Jan;212(1):3-12
references.pmid: 21511884
references.citation: Nutrition. 2006 Sep;22(9):956-64
references.pmid: 16814985
references.citation: Obesity (Silver Spring). 2012 Nov;20(11):2186-93
references.pmid: 22522883
references.citation: Maturitas. 2005 Aug 16;51(4):363-9
references.pmid: 16039409
references.citation: Diabetes Obes Metab. 2012 Jan;14(1):58-66
references.pmid: 21834845
references.citation: Toxicol Sci. 2011 Sep;123(1):48-57
references.pmid: 21705716
references.citation: Mol Cell Endocrinol. 2012 Apr 4;351(2):227-38
references.pmid: 22230815
references.citation: J Clin Endocrinol Metab. 2004 Apr;89(4):1869-78
references.pmid: 15070958
references.citation: BMJ. 2006 Aug 19;333(7564):362-3
references.pmid: 16916811
references.citation: J Nutr. 2006 Feb;136(2):409-14
references.pmid: 16424120
references.citation: Cell Biochem Funct. 1988 Jul;6(3):197-202
references.pmid: 3409480
references.citation: Biochem Biophys Res Commun. 2009 May 15;382(4):646-50
references.pmid: 19265681
references.citation: Metabolism. 2012 Aug;61(8):1100-7
references.pmid: 22386939
references.citation: Nature. 2008 Aug 21;454(7207):1000-4
references.pmid: 18719589
references.citation: Maturitas. 1999 Aug 16;32(3):147-53
references.pmid: 10515671
references.citation: Nat Rev Mol Cell Biol. 2011 Sep 28;12(11):722-34
references.pmid: 21952300
references.citation: Am J Obstet Gynecol. 2007 Aug;197(2):137.e1-7
references.pmid: 17689624
references.citation: FEBS Lett. 2003 Jul 3;546(1):17-24
references.pmid: 12829231
references.citation: Endocr Rev. 1999 Feb;20(1):68-100
references.pmid: 10047974
references.citation: Cell Metab. 2011 Oct 5;14(4):453-65
references.pmid: 21982706
references.citation: Endocr Rev. 2011 Feb;32(1):81-151
references.pmid: 21051590
references.citation: Endocrine. 2008 Jun;33(3):305-16
references.pmid: 19011999
references.citation: Acta Pharmacol Sin. 2011 Feb;32(2):230-8
references.pmid: 21293475
references.citation: PLoS Genet. 2012;8(5):e1002705
references.pmid: 22589742
references.citation: Obes Facts. 2010 Jun;3(3):191-9
references.pmid: 20616609
references.citation: Int J Obes (Lond). 2014 Jun;38(6):812-7
references.pmid: 24213309
references.citation: Endocrinology. 2005 Sep;146(9):3868-74
references.pmid: 15905318
references.citation: Endocrinology. 2004 Jan;145(1):367-83
references.pmid: 14576179
references.citation: Endocrinology. 2009 May;150(5):2109-17
references.pmid: 19164473
references.citation: J Am Acad Dermatol. 2001 Sep;45(3 Suppl):S116-24
references.pmid: 11511861
references.citation: Am J Clin Nutr. 2012 Feb;95(2):297-308
references.pmid: 22158731
references.citation: Mol Cell Endocrinol. 2011 Apr 10;336(1-2):219-23
references.pmid: 21111025
references.citation: Neurosci Lett. 1988 Jan 22;84(2):197-202
references.pmid: 3340326
references.citation: BMC Med. 2011 Mar 16;9:25
references.pmid: 21410966
references.citation: Biochem Biophys Res Commun. 2010 Jul 23;398(2):160-5
references.pmid: 20541531
references.citation: Obes Rev. 2008 May;9(3):236-45
references.pmid: 18034789
references.citation: Biochem Biophys Res Commun. 2012 Aug 10;424(4):710-6
references.pmid: 22800760
references.citation: Endocrinology. 2001 Nov;142(11):4751-7
references.pmid: 11606440
references.citation: Nat Med. 2007 Jan;13(1):89-94
references.pmid: 17195839
references.citation: Handb Exp Pharmacol. 2012;(209):47-75
references.pmid: 22249810
references.citation: Maturitas. 2010 Mar;65(3):262-6
references.pmid: 19962253
references.citation: Diabetes Obes Metab. 2006 Sep;8(5):538-54
references.pmid: 16918589
references.citation: Endocr Rev. 2013 Jun;34(3):309-38
references.pmid: 23460719
references.citation: C R Biol. 2006 Aug;329(8):623-38; discussion 653-5
references.pmid: 16860280
references.citation: Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E340-6
references.pmid: 16954335
references.citation: Reprod Toxicol. 2007 Apr-May;23(3):257-9
references.pmid: 17331698
references.citation: Fertil Steril. 2006 Dec;86(6):1669-75
references.pmid: 17074346
references.citation: J Perinatol. 2012 Feb;32(2):91-6
references.pmid: 21660083
references.citation: J Clin Endocrinol Metab. 2012 Jul;97(7):E1219-23
references.pmid: 22492868
references.citation: Mutat Res. 1999 Jul 30;434(3):243-51
references.pmid: 10486595
references.citation: Mol Endocrinol. 2011 Sep;25(9):1612-23
references.pmid: 21816900
references.citation: Mol Pharmacol. 2005 Oct;68(4):959-65
references.pmid: 15994367
references.citation: J Clin Invest. 2011 Feb;121(2):604-12
references.pmid: 21245576
references.citation: Physiol Rev. 2005 Apr;85(2):495-522
references.pmid: 15788704
references.citation: Prim Care. 2003 Jun;30(2):317-25
references.pmid: 14567150
references.citation: Trends Endocrinol Metab. 2011 Jan;22(1):24-33
references.pmid: 21109497
references.citation: Trends Endocrinol Metab. 1999 Nov;10(9):374-377
references.pmid: 10511697
references.citation: Pediatr Blood Cancer. 2012 Jan;58(1):149-53
references.pmid: 21953791
references.citation: Acta Med Scand Suppl. 1988;723:121-34
references.pmid: 3293356
references.citation: Obes Res. 2004 Apr;12(4):716-24
references.pmid: 15090642
references.citation: J Neuroendocrinol. 2009 Feb;21(2):141-50
references.pmid: 19076267
references.citation: Obes Rev. 2012 Oct;13(10):910-22
references.pmid: 22642554
references.citation: Mol Cell Endocrinol. 2002 Jul 31;193(1-2):7-12
references.pmid: 12160996
references.citation: Med Clin (Barc). 2002 Mar 9;118(8):281-6
references.pmid: 11888494
references.citation: Eur J Endocrinol. 2012 Aug;167(2):245-54
references.pmid: 22645200
references.citation: J Clin Epidemiol. 2009 Oct;62(10):e1-34
references.pmid: 19631507
references.citation: FASEB J. 2001 Apr;15(6):907-15
references.pmid: 11292650
references.citation: Physiol Behav. 2008 Mar 18;93(4-5):842-50
references.pmid: 18191424
references.citation: Am J Obstet Gynecol. 1998 May;178(5):1087-99
references.pmid: 9609589
references.citation: Maturitas. 2008 May 20;60(1):10-8
references.pmid: 18407440
references.citation: Diabetes. 2006 Apr;55(4):978-87
references.pmid: 16567519
references.citation: Am J Physiol Endocrinol Metab. 2013 Jun 1;304(11):E1167-74
references.pmid: 23531620
references.citation: J Biol Chem. 2000 Apr 14;275(15):11404-11
references.pmid: 10753956
references.citation: Endocr Rev. 2000 Dec;21(6):697-738
references.pmid: 11133069
references.citation: Endocr Rev. 1993 Feb;14(1):72-93
references.pmid: 8491156
references.citation: FASEB J. 2012 Jun;26(6):2383-93
references.pmid: 22366643
references.citation: Circulation. 2012 Jun 5;125(22):2782-91
references.pmid: 22665886
references.citation: J Endocrinol Invest. 2010 Feb;33(2):109-12
references.pmid: 20348837
references.citation: Endocr Rev. 1996 Dec;17(6):670-97
references.pmid: 8969973
references.citation: Am J Physiol Endocrinol Metab. 2012 Aug 15;303(4):E445-56
references.pmid: 22550066
references.citation: Endocr Rev. 2006 Dec;27(7):710-18
references.pmid: 17122358
references.citation: Mol Endocrinol. 2014 Feb;28(2):173-82
references.pmid: 24284822
references.citation: Obes Res. 2002 Jun;10(6):424-31
references.pmid: 12055317
references.citation: Endocr Rev. 2009 Jun;30(4):293-342
references.pmid: 19502515
references.citation: Ann Intern Med. 2000 Dec 19;133(12):933-41
references.pmid: 11119394
references.citation: J Clin Invest. 2011 Apr;121(4):1424-8
references.pmid: 21364278
references.citation: Mol Endocrinol. 2009 Aug;23(8):1127-34
references.pmid: 19372238
references.citation: Cell Physiol Biochem. 2007;20(6):877-86
references.pmid: 17982270
references.citation: Arq Bras Endocrinol Metabol. 2009 Mar;53(2):120-8
references.pmid: 19466203
references.citation: Cell. 2001 Mar 9;104(5):719-30
references.pmid: 11257226
references.citation: Eur J Endocrinol. 2012 Oct;167(4):543-51
references.pmid: 22872467
references.citation: Metabolism. 2002 Nov;51(11):1397-401
references.pmid: 12404187
references.citation: Curr Pharm Des. 2012;18(23):3421-31
references.pmid: 22632982
references.citation: J Bone Miner Res. 2006 May;21(5):780-9
references.pmid: 16734394
references.citation: Endocrinology. 2012 Mar;153(3):1031-8
references.pmid: 22253432
references.citation: Mitochondrion. 2008 Sep;8(4):329-37
references.pmid: 18375192
references.citation: Curr Opin Pharmacol. 2012 Jun;12(3):363-71
references.pmid: 22398320
references.citation: Cell Metab. 2011 Sep 7;14(3):289-99
references.pmid: 21907136
references.citation: J Pept Res. 2004 May;63(5):399-408
references.pmid: 15140157
references.citation: Physiol Behav. 2010 Feb 9;99(2):175-80
references.pmid: 19555704
references.citation: Endocr Rev. 2005 May;26(3):322-30
references.pmid: 15817672
references.citation: J Clin Endocrinol Metab. 2014 Jan;99(1):151-9
references.pmid: 24217905
references.citation: Metabolism. 1999 Nov;48(11):1371-7
references.pmid: 10582544
references.citation: J Clin Endocrinol Metab. 2003 Jun;88(6):2404-11
references.pmid: 12788835
references.citation: Endocrinology. 2009 Jun;150(6):2512-7
references.pmid: 19372196
references.citation: Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E145-50
references.pmid: 15713686
references.citation: Obesity (Silver Spring). 2006 Aug;14 Suppl 5:228S-233S
references.pmid: 17021372
references.citation: Am J Hum Biol. 2012 Sep-Oct;24(5):602-10
references.pmid: 22513997
references.citation: Endocrinology. 2009 Nov;150(11):4941-9
references.pmid: 19797119
references.citation: Endocrinology. 2001 Nov;142(11):4813-7
references.pmid: 11606448
references.citation: Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):143-9
references.pmid: 20160646
references.citation: Endocrinology. 2004 May;145(5):2283-90
references.pmid: 14726443
references.citation: PLoS One. 2011 Apr 22;6(4):e19107
references.pmid: 21544212
references.citation: Neuropharmacology. 2012 Jul;63(1):57-75
references.pmid: 22200617
references.citation: Biol Res Nurs. 2010 Jul;12(1):84-97
references.pmid: 20702456
references.citation: J Mol Cell Cardiol. 2004 Nov;37(5):921-9
references.pmid: 15522269
references.citation: Obesity (Silver Spring). 2011 Apr;19(4):784-91
references.pmid: 20930715
references.citation: Climacteric. 2012 Oct;15(5):419-29
references.pmid: 22978257
references.citation: Endocrinology. 2006 Apr;147(4):1986-96
references.pmid: 16384865
references.citation: Nature. 2001 Jan 11;409(6817):194-8
references.pmid: 11196643
references.citation: Proteomics. 2005 Dec;5(18):4936-45
references.pmid: 16237733
references.citation: Am J Physiol. 1999 Feb;276(2):E317-25
references.pmid: 9950792
references.citation: Physiol Behav. 2006 Jul 30;88(4-5):523-8
references.pmid: 16793070
references.citation: Nature. 2001 Jan 18;409(6818):307-12
references.pmid: 11201732
references.citation: Public Health Nutr. 2013 Apr;16(4):573-81
references.pmid: 22583613
references.citation: J Obes. 2010;2010:
references.pmid: 20871654
references.citation: Steroids. 2005 May-Jun;70(5-7):361-3
references.pmid: 15862818