title: Genetic polymorphisms of ORAI1 and chronic kidney disease in Taiwanese population.
abstract: Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD). The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involved in the regulation of immune system. Hence, we conducted a case-control study to determine whether the genetic polymorphisms of ORAI1 gene is a susceptibility factor to CKD and its clinical features in a Taiwanese population. Five hundred seventy-nine CKD patients from a hospital-based CKD care program were included in the study. Five tagging single nucleotide polymorphisms (tSNPs) of ORAI1 were selected from the genotyping data of the Han Chinese population from the HapMap project. Among these polymorphisms, rs12313273 was found to be significantly associated with elevated serum calcium levels, which has been linked to increased risk of death in CKD patients. To have a better management of serum calcium, we suggest that ORAI1 polymorphisms might be used as a potential biomarker for initiating non-calcium-based phosphate binder in CKD patients in the future.
authors.affiliation: Division of Nephrology, Department of Medicine, Kaohsiung Medical University Hospital/Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Daw-Yang
authors.initials: DY
authors.lastname: Hwang
authors.affiliation: Department of Pharmacy, Taipei Medical University Hospital, Taipei 110, Taiwan ; Department of Clinical Pharmacy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan ; Clinical Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan.
authors.forename: Shu-Chen
authors.initials: SC
authors.lastname: Chien
authors.affiliation: Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Hsu
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan ; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Chih-Chin
authors.initials: CC
authors.lastname: Kao
authors.affiliation: Department of Pharmacy, Taipei Medical University Hospital, Taipei 110, Taiwan ; Department of Clinical Pharmacy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Shih-Ying
authors.initials: SY
authors.lastname: Cheng
authors.affiliation: Department of Pharmacy, Taipei Medical University Hospital, Taipei 110, Taiwan ; Department of Medical Genetics, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Hui-Chen
authors.initials: HC
authors.lastname: Lu
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan ; Department of Internal Medicine, School of Medicine, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Mai-Szu
authors.initials: MS
authors.lastname: Wu
authors.affiliation: Division of Nephrology, Department of Medicine, Kaohsiung Medical University Hospital/Kaohsiung Medical University, Kaohsiung 807, Taiwan ; Department of Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan ; Faculty of Renal Care, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Jer-Ming
authors.initials: JM
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015220:Calcium Channels / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D000071740:ORAI1 Protein; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D015220:Calcium Channels; D005819:Genetic Markers; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human
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