title: Age-specific serum antimüllerian hormone levels in women with and without polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine the serum antimüllerian hormone (AMH) reference values in Chinese women with and without polycystic ovary syndrome (PCOS), and the associations of AMH with clinical or biochemical characteristics.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Academic institutions.
  
  
  METHODS
  Totals of 1,896 infertile control women and 304 women with PCOS.
  
  
  METHODS
  None.
  
  
  METHODS
  Serum basal AMH levels and clinical, endocrine, and metabolic parameters.
  
  
  RESULTS
  In the same age group, serum AMH levels were higher in PCOS women than those without PCOS. AMH levels were not significantly related to indices of insulin resistance or metabolic-related variables in both groups. In the infertile control group, AMH increased with antral follicle count (AFC) and LH and decreased with age, body mass index (BMI), and FSH. In the PCOS group, AMH levels showed positive correlations with LH, AFC, and T and negative correlations with BMI. The median AMH levels were 2.35 ng/mL for ages 20-31 years, 1.58 ng/mL for ages 32-34 years, 1.30 ng/mL for ages 35-37 years, 0.96 ng/mL for ages 38-40 years, 1.05 ng/mL for ages 41-43 years, and 0.67 ng/mL for ages>43 years in the control group and 4.38 ng/mL for ages 20-31 years, 3.47 ng/mL for ages 32-34 years, and 3.30 ng/mL for ages 35-37 years in the PCOS group.
  
  
  CONCLUSIONS
  This study determined reference values of serum AMH in Chinese women with and without PCOS. Elevated serum AMH levels do not affect the risk of insulin resistance or metabolic syndrome.
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated with Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory for Reproductive Endocrinology of the Ministry of Education; and Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of China.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated with Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory for Reproductive Endocrinology of the Ministry of Education; and Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated with Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory for Reproductive Endocrinology of the Ministry of Education; and Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Cui
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated with Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory for Reproductive Endocrinology of the Ministry of Education; and Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Han
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated with Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory for Reproductive Endocrinology of the Ministry of Education; and Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Gao
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated with Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory for Reproductive Endocrinology of the Ministry of Education; and Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of China. Electronic address: chenzijiang@hotmail.com.
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002681:China; D005260:Female; D005298:Fertility; D006801:Humans; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D011379:Prognosis; D012189:Retrospective Studies; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone
keywords: AFC; AMH; PCOS; ovarian reserve