title: [Effect of high humidity environment on immune function in rats].
abstract: OBJECTIVE
  To investigate effects of the variation of immune function in high humidity environment in different time, and lay a foundation for further study of the related mechanism.
  
  
  METHODS
  Thirty SD rats were divided into 3 groups (n = 10): 20 day group, 40 day group in 90% relative humidity chamber and control group in normal relative humidity. Peripheral blood and spleens were collected to detect the levels of T lymphocyte subsets by Flow Cytometery.
  
  
  RESULTS
  In peripheral blood of the 20 day group rats, the CD3+ %, CD4+ %, CD8+ % and CD4+/CD8+ were 52.91 +/- 6.27, 37.80 +/- 4.11, 14.85 +/- 3.73 and 2.72 +/- 0.82 separately. Expect CD3+ %, they all had significant differences (P < 0.05). In addition, the data of the 40 day group rats showed no diversity in statistics. In spleen, CD8+ % of the 20 day group rats was 6.23 +/- 2.87 with significant differences (P < 0.05) and IgG, IgA and IgM did not change a lot in blood serum of the high humidity groups except C3 of the 20 days group (P < 0.05).
  
  
  CONCLUSIONS
  In high humidity environment, the immune function of the rats increased in the initial stage. As time went on, the immune function gradually went to normal level through the self adjustment.
authors.forename: Xin
authors.initials: X
authors.lastname: Guo
authors.forename: Kun
authors.initials: K
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Yun
authors.initials: Y
authors.lastname: Yang
authors.forename: Fu-Qiang
authors.initials: FQ
authors.lastname: Song
authors.forename: Yong-He
authors.initials: YH
authors.lastname: Hu
mesh_terms: D000064:Acclimatization; D000818:Animals; D006813:Humidity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*