title: The neurobiological pathogenesis of poststroke depression.
abstract: Poststroke depression (PSD) is an important consequence after stroke, with negative impact on stroke outcome. The pathogenesis of PSD is complicated, with some special neurobiological mechanism, which mainly involves neuroanatomical, neuron, and biochemical factors and neurogenesis which interact in complex ways. Abundant studies suggested that large lesions in critical areas such as left frontal lobe and basal ganglia or accumulation of silent cerebral lesions might interrupt the pathways of monoamines or relevant pathways of mood control, thus leading to depression. Activation of immune system after stroke produces more cytokines which increase glutamate excitotoxicity, results in more cell deaths of critical areas and enlargement of infarctions, and, together with hypercortisolism induced by stress or inflammation after stroke which could decrease intracellular serotonin transporters, might be the key biochemical change of PSD. The interaction among cytokines, glucocorticoid, and neurotrophin results in the decrease of hippocampal neurogenesis which has been proved to be important for mood control and pharmaceutical effect of selective serotonin reuptake inhibitors and might be another promising pathway to understand the pathogenesis of PSD. In order to reduce the prevalence of PSD and improve the outcome of stroke, more relevant studies are still required to clarify the pathogenesis of PSD.
authors.affiliation: The Yiwu Affiliated Hospital of Zhejiang University, School of Medicine, Huajiachi Campus, Kaixuan Road No. 268, Jianggan District, Hangzhou 310029, Zhejiang, China.
authors.forename: Chao
authors.identifier: 0000-0003-0155-9159
authors.initials: C
authors.lastname: Feng
authors.affiliation: Department of Neurology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Min
authors.identifier: 0000-0001-6343-7726
authors.initials: M
authors.lastname: Fang
authors.affiliation: Department of Neurology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Liu
mesh_terms: D003863:Depression / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007107:Immune System / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000502:physiology; D020521:Stroke / Q000150:complications* / Q000503:physiopathology* / Q000523:psychology
chemical_list: D005938:Glucocorticoids; D018377:Neurotransmitter Agents
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