title: Use of artemisinin and its derivatives to treat HPV-infected/transformed cells and cervical cancer: a review.
abstract: Cervical cancer and HPV-related diseases remain a burden in the developing world. While much progress has been gained in the detection of HPV and preneoplastic cervical lesions, the rate-limiting step in the prevention of cervical cancer is management of these women. A natural compound, artemisinin, and its derivatives appear to hold promise as a simple means of treatment. Laboratory studies have shown that this compound, and its derivatives, have activity against HPV-infected and -transformed cells and cervical cancer cells. In situations of compassionate use, studies have also demonstrated efficacy in clinical situations. Well-designed clinical trials relating to its use should be undertaken.
authors.affiliation: Division of Gynecologic Oncology, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Goodrich
authors.forename: C Richard
authors.initials: CR
authors.lastname: Schlegel
authors.forename: Guixang
authors.initials: G
authors.lastname: Wang
authors.forename: Jerome L
authors.initials: JL
authors.lastname: Belinson
mesh_terms: D052685:Alphapapillomavirus; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D037621:Artemisinins / Q000494:pharmacology / Q000627:therapeutic use*; D002461:Cell Line, Transformed; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000821:virology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D037621:Artemisinins; C031327:artemisinin