title: Serum adropin levels are decreased in patients with acute myocardial infarction.
abstract: OBJECTIVE
  Adropin is a recently identified bioactive protein that is important for energy homeostasis and maintaining insulin sensitivity. We sought to detect serum adropin levels in acute myocardial infarction (AMI) patients.
  
  
  METHODS
  We enrolled 138 AMI patients, 114 stable angina pectoris (SAP) patients and 75 controls. Adropin levels were measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Serum adropin levels were significantly lower in patients with AMI compared with SAP patients or controls (P<0.01). Multivariate logistic regression demonstrated that lower adropin was the independent predictor for the presence of AMI in coronary artery disease (CAD) patients (P<0.01). Serum adropin levels were negatively associated with body mass index (BMI) (P<0.01) and triglyceride levels (P<0.05) in AMI patients.
  
  
  CONCLUSIONS
  Decreased serum adropin levels are associated with the presence of AMI in CAD patients. These results revealed that adropin might represent as a novel biomarker for predicting AMI onset in CAD patients.
authors.affiliation: Department of Emergency Medicine, Xijing hospital, Fourth Military Medical University, No. 17 Changle West Road, Xi'an 710032, PR China.
authors.forename: Hou-you
authors.initials: HY
authors.lastname: Yu
authors.affiliation: Department of Emergency Medicine, Xijing hospital, Fourth Military Medical University, No. 17 Changle West Road, Xi'an 710032, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.affiliation: Department of Anaesthiology, Wuhan general Hospital of Guangzhou Command, No. 627 Wuluo Road, Wuhan, 430070, PR China.
authors.forename: Ming-chun
authors.initials: MC
authors.lastname: Wu
authors.affiliation: Department of Emergency Medicine, Xijing hospital, Fourth Military Medical University, No. 17 Changle West Road, Xi'an 710032, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Emergency Medicine, Xijing hospital, Fourth Military Medical University, No. 17 Changle West Road, Xi'an 710032, PR China. Electronic address: xijingyinwen@126.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Yin
mesh_terms: D000787:Angina Pectoris / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins; D003324:Coronary Artery Disease / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood*; D010455:Peptides / Q000097:blood*
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; C568440:Enho protein, human; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides
keywords: Acute myocardial infarction; Adropin; Atherosclerosis; Biomarkers; Coronary artery disease