title: Intractable Polyuria Mimicking Diabetes Insipidus-Source Traced to Vecuronium Infusion.
abstract: Continuous infusion of vecuronium is a commonly used technique for patients requiring prolonged neuromuscular blockade for mechanical ventilation. As compared with older neuromuscular blocking agents, it confers the advantages of rapid excretion and intermediate duration of action. Prolongation of neuromuscular blockade and muscle weakness are the known complications of continuous vecuronium infusion. This report attempts to describe polyuria, as a hitherto unknown complication of vecuronium infusion, which can occur due to the mannitol present in commercially available preparation of vecuronium bromide.
authors.affiliation: 1Department of Anaesthesia, Gian Sagar Medical College, Patiala, India; 2Department of Anaesthesia and Critical Care Medicine (Trauma), All India Institute of Medical Sciences, New Delhi, India; and 3Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Rudrashish
authors.initials: R
authors.lastname: Haldar
authors.forename: Sukhen
authors.initials: S
authors.lastname: Samanta
authors.forename: Ankush
authors.initials: A
authors.lastname: Singla
mesh_terms: D000328:Adult; D003919:Diabetes Insipidus / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008353:Mannitol / Q000009:adverse effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D011141:Polyuria / Q000139:chemically induced* / Q000175:diagnosis; D014673:Vecuronium Bromide / Q000009:adverse effects*
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D008353:Mannitol; D014673:Vecuronium Bromide