title: Three-component Pd/Cu-catalyzed cascade reactions of cyclic iodoniums, alkynes, and boronic acids: an approach to methylidenefluorenes.
abstract: Linear diaryliodonium salts are widely used as arylating reagents for C-C and C-X bond formation. Meanwhile, synthetic applications of cyclic iodoniums are relatively rare although they offer the opportunity to set up reaction cascades. We demonstrate an atom and step economical three-component reaction involving cyclic diphenyleneiodoniums, alkynes, and boronic acids, resulting in the construction of methylidenefluorenes in a single operation. Our route enables facile access to both symmetrical and unsymmetrical methylidenefluorene derivatives, compounds that have attracted interest due to their optical properties.
authors.affiliation: Sun Yat-sen University Cancer Center , State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou 510060, China.
authors.forename: Daqian
authors.initials: D
authors.lastname: Zhu
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Wu
authors.forename: Baojian
authors.initials: B
authors.lastname: Wu
authors.forename: Bingling
authors.initials: B
authors.lastname: Luo
authors.forename: A
authors.initials: A
authors.lastname: Ganesan
authors.forename: Fu-Hai
authors.initials: FH
authors.lastname: Wu
authors.forename: Rongbiao
authors.initials: R
authors.lastname: Pi
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Shijun
authors.initials: S
authors.lastname: Wen
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009861:Onium Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D005449:Fluorenes; D009861:Onium Compounds; D010165:Palladium; D003300:Copper