title: G protein-coupled receptors and the regulation of autophagy.
abstract: Autophagy is an important catabolic cellular process that eliminates damaged and unnecessary cytoplasmic proteins and organelles. Basal autophagy occurs during normal physiological conditions, but the activity of this process can be significantly altered in human diseases. Thus, defining the regulatory inputs and signals that control autophagy is essential. Nutrients are key modulators of autophagy. Although autophagy is generally accepted to be regulated in a cell-autonomous fashion, recent studies suggest that nutrients can modulate autophagy in a systemic manner by inducing the secretion of hormones and neurotransmitters that regulate G protein-coupled receptors (GPCRs). Emerging studies show that GPCRs also regulate autophagy by directly detecting extracellular nutrients. We review the role of GPCRs in autophagy regulation, highlighting their potential as therapeutic drug targets.
authors.affiliation: Department of Physiology and Pharmacology, Des Moines University, Des Moines, IA 50312, USA. Electronic address: eric.wauson@dmu.edu.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Wauson
authors.affiliation: Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.
authors.forename: Hashem A
authors.initials: HA
authors.lastname: Dbouk
authors.affiliation: Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.
authors.forename: Anwesha B
authors.initials: AB
authors.lastname: Ghosh
authors.affiliation: Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA. Electronic address: melanie.cobb@UTsouthwestern.edu.
authors.forename: Melanie H
authors.initials: MH
authors.lastname: Cobb
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D043562:Receptors, G-Protein-Coupled
keywords: AMPK; GLP-1 receptor; amino acid sensing GPCRs; autophagy; mTORC1; muscarinic receptor; β-adrenergic receptor
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