title: Successful management of neonatal alloimmune thrombocytopenia in the second pregnancy: a case report.
abstract: Neonatal alloimmune thrombocytopenia is a serious disease, in which the mother produces antibodies against fetal platelet antigens inherited from the father; it is still an underdiagnosed disease. This disease is considered the platelet counterpart of the RhD hemolytic disease of the fetus and newborn, yet in neonatal alloimmune thrombocytopenia the first child is affected with fetal and/or neonatal thrombocytopenia. There is a significant risk of intracranial hemorrhage and severe neurological impairment, with a tendency for earlier and more severe thrombocytopenia in subsequent pregnancies. This article reports a case of neonatal alloimmune thrombocytopenia in the second pregnancy affected and discusses diagnosis, management and the clinical importance of this disease.
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Fabiana Mendes
authors.initials: FM
authors.lastname: Conti
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Sergio
authors.initials: S
authors.lastname: Hibner
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Thiago Henrique
authors.initials: TH
authors.lastname: Costa
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Marcia Regina
authors.initials: MR
authors.lastname: Dezan
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Maria Giselda
authors.initials: MG
authors.lastname: Aravechia
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Ricardo Antonio D Almeida
authors.initials: RA
authors.lastname: Pereira
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Andrea Tiemi
authors.initials: AT
authors.lastname: Kondo
authors.affiliation: Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Élbio Antônio
authors.initials: ÉA
authors.lastname: D'Amico
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Mariza
authors.initials: M
authors.lastname: Mota
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: José Mauro
authors.initials: JM
authors.lastname: Kutner
mesh_terms: D000328:Adult; D016824:Antigens, Human Platelet / Q000235:genetics; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000000981:diagnostic imaging / Q000517:prevention & control; D008297:Male; D010976:Platelet Count; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D018570:Risk Assessment; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000000981:diagnostic imaging / Q000628:therapy*; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal
chemical_list: D016824:Antigens, Human Platelet; D016756:Immunoglobulins, Intravenous
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