title: Granulocyte colony-stimulating factor in the treatment of acute radiation syndrome: a concise review.
abstract: This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future.
authors.affiliation: Department of Molecular Cytology and Cytometry, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, Brno CZ-612 65, Czech Republic. hofer@ibp.cz.
authors.forename: Michal
authors.initials: M
authors.lastname: Hofer
authors.affiliation: Department of Molecular Cytology and Cytometry, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, Brno CZ-612 65, Czech Republic. jirina.pospisil@seznam.cz.
authors.forename: Milan
authors.initials: M
authors.lastname: Pospíšil
authors.affiliation: Department of Molecular Cytology and Cytometry, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, Brno CZ-612 65, Czech Republic. komurkova@ibp.cz.
authors.forename: Denisa
authors.initials: D
authors.lastname: Komůrková
authors.affiliation: Department of Molecular Cytology and Cytometry, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, Brno CZ-612 65, Czech Republic. hoferovaz@centrum.cz.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Hoferová
mesh_terms: D054508:Acute Radiation Syndrome / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D001853:Bone Marrow / Q000473:pathology / Q000528:radiation effects; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis / Q000627:therapeutic use*; D006801:Humans; D007377:Interleukin-3 / Q000627:therapeutic use; D008565:Membrane Proteins / Q000627:therapeutic use; D018788:Radioactive Hazard Release; D011994:Recombinant Proteins / Q000627:therapeutic use; D019089:Stem Cell Factor / Q000627:therapeutic use; D013926:Thrombopoietin / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D007377:Interleukin-3; D008565:Membrane Proteins; D011994:Recombinant Proteins; D019089:Stem Cell Factor; C084881:flt3 ligand protein; D016179:Granulocyte Colony-Stimulating Factor; D013926:Thrombopoietin
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