title: Tau-induced neurodegeneration: mechanisms and targets.
abstract: The accumulation of hyperphosphorylated tau is a common feature of several dementias. Tau is one of the brain microtubule-associated proteins. Here we discuss tau's functions in microtubule assembly and stabilization and with regard to its interactions with other proteins. We describe and analyze important post-translational modifications: hyperphosphorylation, ubiquitination, glycation, glycosylation, nitration, polyamination, proteolysis, acetylation, and methylation. We discuss how these post-translational modifications can alter tau's biological function. We analyze the role of mitochondrial health in neurodegeneration. We propose that microtubules could be a therapeutic target and review different approaches. Finally, we consider whether tau accumulation or its conformational change is related to tau-induced neurodegeneration, and propose a mechanism of neurodegeneration.
authors.affiliation: Department of Biology and Center for Developmental Neuroscience, College of Staten Island, Graduate Center, The City University of New York, Staten Island, NY, 10314, USA.
authors.forename: Cindy
authors.initials: C
authors.lastname: Beharry
authors.forename: Leah S
authors.initials: LS
authors.lastname: Cohen
authors.forename: Jing
authors.initials: J
authors.lastname: Di
authors.forename: Kawsar
authors.initials: K
authors.lastname: Ibrahim
authors.forename: Susan
authors.initials: S
authors.lastname: Briffa-Mirabella
authors.forename: Alejandra del C
authors.initials: Adel C
authors.lastname: Alonso
mesh_terms: D000818:Animals; D003704:Dementia / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008870:Microtubules / Q000378:metabolism / Q000473:pathology; D009410:Nerve Degeneration / Q000378:metabolism* / Q000473:pathology; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016875:tau Proteins
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