title: [Risk factors and predictive factors of cognitive deterioration in patients of vascular cognitive impairment no dementia with subcortical ischemic vascular disease].
abstract: OBJECTIVE
  To explore the independent risk factors and predictive factors of cognitive deterioration in patients of vascular cognitive impairment no dementia with subcortical ischemic vascular disease (VCIND-SIVD).
  
  
  METHODS
  The clinical and neuropsychological characteristics of 96 VCIND-SIVD patients were collected and their cognitive states re-assessed after one year. The distribution of continuous and categorical variables was examined with univariate analysis. And Logistic regression in multivariate modeling was employed to identify the risk and predictive factors of cognitive deterioration.
  
  
  RESULTS
  After 1-year follow-up, 8 patients dropped out, 2 died and the remainder remained. There were 48 males and 38 females with an average age of 64.3 ± 5.4 years. Among them, 17 (19.8%) deteriorated into dementia, 24 (27.9%) upgraded to normal cognition and 45 (52.3%) maintained their cognitive status. They were divided into dementia group (cognition deteriorating into dementia) and control group (elevated/sustained cognition). After univariate analysis of general information and vascular risk factors, Logistic regression demonstrated that education level (P < 0.05, OR = 0.7) was a preventive factor of dementia while age (P < 0.05, OR = 1.2), hypertension (P < 0.05, OR = 5.6) and high homocysteine (P < 0.05, OR = 4.2) were independent risk factors of dementia. After univariate analysis of neuropsychological scores, Logistic regression demonstrated that visual reproduction-immediate recall (P < 0.05, OR = 3.4), digit span forward (P < 0.05, OR = 1.2), clock drawing test (P < 0.05, OR = 6.8) and completion time of London tower (P < 0.05, OR = 5.4) were predictive factors of dementia.
  
  
  CONCLUSIONS
  VCIND-SIVD patients with low score of visual reproduction-immediate recall, digit span forward, clock drawing test and completion time of London tower should receive vigorous controls of hypertension and high homocysteine.
authors.affiliation: Department of Neurology II, the First People's Hospital of Shaoguan City, Shaoguan 512000, China. Email: gdtancheng@sina.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Tan
authors.affiliation: Department of Neurology II, the First People's Hospital of Shaoguan City, Shaoguan 512000, China.
authors.forename: Wenhong
authors.initials: W
authors.lastname: Peng
authors.affiliation: Department of Neurology II, the First People's Hospital of Shaoguan City, Shaoguan 512000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Deng
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000175:diagnosis* / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis*; D005260:Female; D006801:Humans; D049292:Leukoaraiosis / Q000175:diagnosis / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012307:Risk Factors