title: Ossification defects detected in CT scans represent early osteochondrosis in the distal femur of piglets.
abstract: The purpose of the current study was to validate the use of CT for selection against osteochondrosis in pigs by calculating positive predictive value and comparing it to the positive predictive value of macroscopic evaluation, using histological examination as the reference standard. Eighteen male, hereditarily osteochondrosis-predisposed piglets underwent terminal examination at biweekly intervals from the ages of 82-180 days old, including CT scanning, macroscopic, and histological evaluation of the left distal femur. Areas of ischemic chondronecrosis (osteochondrosis) were confirmed in histological sections from 44/56 macroscopically suspected lesions, resulting in a positive predictive value of 79% (95% CI: 67-84%). Suspected lesions, that is; focal, radiolucent defects in the ossification front in CT scans corresponded to areas of ischemic chondronecrosis in 36/36 histologically examined lesions, resulting in a positive predictive value of 100% (95% CI: 90-100%). CT was superior to macroscopic evaluation for diagnosis of early stages of osteochondrosis in the distal femur of piglets. The current histologically validated observations can potentially be extrapolated to diagnostic monitoring of juvenile osteochondritis dissecans in children, or to animal models of human juvenile articular cartilage injury and repair.
authors.affiliation: Norwegian School of Veterinary Science, Companion Animal Clinical Sciences, Equine Section, Ullevålsveien 72, 0454 Oslo, Norway.
authors.forename: Kristin
authors.initials: K
authors.lastname: Olstad
authors.forename: Jørgen
authors.initials: J
authors.lastname: Kongsro
authors.forename: Eli
authors.initials: E
authors.lastname: Grindflek
authors.forename: Nils Ivar
authors.initials: NI
authors.lastname: Dolvik
mesh_terms: D000375:Aging / Q000473:pathology; D000818:Animals; D005269:Femur / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D010008:Osteochondritis Dissecans / Q000000981:diagnostic imaging* / Q000473:pathology; D055034:Osteochondrosis / Q000000981:diagnostic imaging* / Q000473:pathology; D011237:Predictive Value of Tests; D013552:Swine; D014057:Tomography, X-Ray Computed
keywords: computed tomography; histology; ossification defects; osteochondritis dissecans; pediatric