title: Role of Fbxw7 expression in hepatocellular carcinoma and adjacent non-tumor liver tissue.
abstract: OBJECTIVE
  Fbxw7 is a tumor suppressor gene through ubiquitination and degradation of multiple oncoproteins. Loss of Fbxw7 expression is frequently observed in various human cancers. In the present study, we examined the role of Fbxw7 expression in both non-tumor liver tissues and tumor tissues on clinicopathological significance.
  
  
  METHODS
  Sixty-six patients with hepatocellular carcinoma (HCC), who underwent hepatectomy, were divided into two groups: high and low gene-expression group, based on the Fbxw7 expression level. We compared the clinicopathological factors between the high expression and low expression groups in both tumor and non-tumor tissues.
  
  
  RESULTS
  Fbxw7 messenger RNA expression level in the non-tumor tissues was significantly higher than that in the tumor tissues. In the analysis of Fbxw7 expression in tumor and non-tumor tissues, disease-free survival rate in the Fbxw7 high expression group was significantly higher than that in the low expression group. In multivariable analysis, Fbxw7 low expression in both tumor and non-tumor tissue was detected as the strongest independent risk factor for HCC recurrence.
  
  
  CONCLUSIONS
  Low Fbxw7 expression in both tumor and non-tumor tissue may be an independent prognostic factor for tumor recurrence after hepatectomy in patients with HCC.
authors.affiliation: Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima Graduate School, Tokushima, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Imura
authors.forename: Lkhagva-Ochir
authors.initials: LO
authors.lastname: Tovuu
authors.forename: Tohru
authors.initials: T
authors.lastname: Utsunomiya
authors.forename: Yuji
authors.initials: Y
authors.lastname: Morine
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ikemoto
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Arakawa
authors.forename: Mami
authors.initials: M
authors.lastname: Kanamoto
authors.forename: Shuichi
authors.initials: S
authors.lastname: Iwahashi
authors.forename: Yu
authors.initials: Y
authors.lastname: Saito
authors.forename: Chie
authors.initials: C
authors.lastname: Takasu
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yamada
authors.forename: Daichi
authors.initials: D
authors.lastname: Ishikawa
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Bando
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Shimada
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D044783:F-Box Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D000073979:F-Box-WD Repeat-Containing Protein 7; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D015513:Oncogene Proteins / Q000378:metabolism; D011379:Prognosis; D059748:Proteolysis; D012307:Risk Factors; D044767:Ubiquitin-Protein Ligases / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D054875:Ubiquitination / Q000235:genetics
chemical_list: D018797:Cell Cycle Proteins; D044783:F-Box Proteins; D000073979:F-Box-WD Repeat-Containing Protein 7; C513273:FBXW7 protein, human; D015513:Oncogene Proteins; D044767:Ubiquitin-Protein Ligases
keywords: carcinogenesis; gene expression; multicentric recurrence; prognosis