title: Association of a genetic variant in microRNA-146a with risk of colorectal cancer: a population-based case-control study.
abstract: MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate target gene expression at the posttranscriptional level. Although recent studies have indicated that miR-146a is involved in the tumorigenesis of various types of malignancies, few studies have investigated its role in colorectal cancer. In the current study, we examined the expression of miR-146a in colorectal cancer tissue and adjacent normal controls using publicly available expression profiling data. We then conducted a population-based case-control study which included 554 colorectal cancer cases and 566 matched healthy controls to assess the association of a genetic variant (rs2910164) in miR-146a with colorectal cancer susceptibility. We observed decreased expression of miR-146a in rectal cancer tissue compared with adjacent normal controls (P < 0.001). Association between miR-146a rs2910164 polymorphism and risk of colorectal cancer was detected with effect modification by alcohol drinking status (P for interaction = 0.010). Among non-alcohol drinkers, individuals with CC/CG genotype had an increased risk of developing colorectal cancer compared with those carrying GG genotype (odds ratio (OR) = 1.63, 95 % confidence interval (CI): 1.07 ∼ 2.47). Our findings indicate an association between miR-146a dysregulation and colorectal cancer, and suggest that miR-146a may play a role in colorectal carcinogenesis. Further large population-based prospective studies as well as mechanistic investigations are warranted to validate our findings.
authors.affiliation: Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, 866 Yuhangtang Road, Hangzhou, 310058, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Mao
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Li
authors.forename: Fangyuan
authors.initials: F
authors.lastname: Jing
authors.forename: Shaofang
authors.initials: S
authors.lastname: Cai
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Qilong
authors.initials: Q
authors.lastname: Li
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Ma
authors.forename: Jianbing
authors.initials: J
authors.lastname: Wang
authors.forename: Mingjuan
authors.initials: M
authors.lastname: Jin
authors.forename: Kun
authors.initials: K
authors.lastname: Chen
mesh_terms: D000368:Aged; D063646:Carcinogenesis / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs
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