title: Apolipoprotein E gene polymorphism and risk for coronary heart disease in the Chinese population: a meta-analysis of 61 studies including 6634 cases and 6393 controls.
abstract: BACKGROUND
  Numerous studies have evaluated the association between the apolipoprotein E (apoE) gene polymorphisms in coronary heart disease (CHD). However, the results remain uncertain. We carried out a meta-analysis to derive a more comprehensive estimation of the association in Chinese population.
  
  
  METHODS
  Case-control studies in Chinese and English publications were identified by searching databases of PubMed, EMBASE, Web of Science, CNKI, CBM, Wanfang, VIP and hand searching of relevant journals and the reference lists of retrieved articles. Odds ratio (OR) and 95% confidence interval (CI) were applied to assess the strength of the associations. Subgroup analysis and sensitivity analysis were performed to explore the between-study heterogeneity.
  
  
  RESULTS
  We finally identified 61 relevant studies which comprised 6634 case-patients and 6393 controls. The pooled OR for ε4 carriers was 96% higher than the ε3/3 genotype for CHD (OR, 1.96; 95% CI, 1.70 to 2.24; P<0.001). However, there was no evidence of statistically significant association between ε2 carriers and risk of CHD (OR, 1.02; 95% CI, 0.91 to 1.13; P = 0.729). In the subgroup analysis, different endpoints may partially account for the heterogeneity. No publication bias was found.
  
  
  CONCLUSIONS
  Our meta-analysis suggests that the apoE ε4 allele may be a risk factor for CHD in the Chinese population, however, ε2 allele has no significant association.
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
authors.forename: Ming-duo
authors.initials: MD
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The Fourth Affiliated Hospital of Anhui Medical University, Anhui, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
authors.affiliation: Department of Cardiology, Rizhao People's Hospital, Shandong, China.
authors.forename: Shi-bin
authors.initials: SB
authors.lastname: Qiao
authors.affiliation: Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China; Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: En-jun
authors.initials: EJ
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
authors.forename: Quan-ming
authors.initials: QM
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
authors.forename: Shu-zheng
authors.initials: SZ
authors.lastname: Lv
mesh_terms: D053318:Apolipoprotein E3 / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics; D003327:Coronary Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E
references.citation: Int J Epidemiol. 2013 Apr;42(2):475-92
references.pmid: 23569189
references.citation: Science. 1988 Apr 29;240(4852):622-30
references.pmid: 3283935
references.citation: Atherosclerosis. 2012 Jul;223(1):230-4
references.pmid: 22632920
references.citation: Circulation. 2013 Jan 1;127(1):e6-e245
references.pmid: 23239837
references.citation: Trends Biochem Sci. 2006 Aug;31(8):445-54
references.pmid: 16820298
references.citation: Am J Hum Genet. 1991 Aug;49(2):338-49
references.pmid: 1867194
references.citation: Ann Intern Med. 2004 Jul 20;141(2):137-47
references.pmid: 15262670
references.citation: Neurobiol Aging. 2005 Mar;26(3):363-72
references.pmid: 15639315
references.citation: JAMA. 1994 Dec 7;272(21):1666-71
references.pmid: 7966894
references.citation: Arteriosclerosis. 1988 Jan-Feb;8(1):1-21
references.pmid: 3277611
references.citation: Stat Med. 2002 Jun 15;21(11):1539-58
references.pmid: 12111919
references.citation: Neurobiol Aging. 2004 May-Jun;25(5):641-50
references.pmid: 15172743
references.citation: J Mol Med (Berl). 2005 May;83(5):329-42
references.pmid: 15827760
references.citation: Mol Genet Metab. 2010 Jul;100(3):283-91
references.pmid: 20381392
references.citation: Am J Epidemiol. 2002 Aug 15;156(4):300-10
references.pmid: 12181099
references.citation: Arteriosclerosis. 1989 Mar-Apr;9(2):237-41
references.pmid: 2923580
references.citation: Biomed Pharmacother. 2011 Dec;65(8):597-603
references.pmid: 21705182
references.citation: PLoS Med. 2009 Jul 21;6(7):e1000097
references.pmid: 19621072
references.citation: Atherosclerosis. 2011 Apr;215(2):487-93
references.pmid: 21310412
references.citation: Annu Rev Genomics Hum Genet. 2000;1:507-37
references.pmid: 11701639
references.citation: Biometrics. 1994 Dec;50(4):1088-101
references.pmid: 7786990
references.citation: Nat Clin Pract Cardiovasc Med. 2007 Oct;4(10):558-69
references.pmid: 17893684
references.citation: Lancet. 2002 Jan 19;359(9302):248-52
references.pmid: 11812579
references.citation: Nutr Metab Cardiovasc Dis. 2007 Feb;17(2):148-52
references.pmid: 17306734
references.citation: Free Radic Biol Med. 2002 Jun 1;32(11):1071-5
references.pmid: 12031891
references.citation: Indian J Med Res. 2010 Oct;132:363-78
references.pmid: 20966513
references.citation: Nature. 1977 Oct 13;269(5629):604-7
references.pmid: 199847
references.citation: PLoS One. 2013 Jun 24;8(6):e66924
references.pmid: 23826174
references.citation: JAMA. 2007 Sep 19;298(11):1300-11
references.pmid: 17878422
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: Am J Epidemiol. 2002 Mar 15;155(6):487-95
references.pmid: 11882522
references.citation: Nat Genet. 2011 Mar 06;43(4):333-8
references.pmid: 21378990
references.citation: J Atheroscler Thromb. 1995;2 Suppl 1:S29-33
references.pmid: 9225228
references.citation: Ann Hum Genet. 2011 Mar;75(2):255-65
references.pmid: 21241273
references.citation: Ann Hum Genet. 1955 Jun;19(4):251-3
references.pmid: 14388528