title: Respiratory syncytial virus increases lung cellular bioenergetics in neonatal C57BL/6 mice.
abstract: We have previously reported that lung cellular bioenergetics (cellular respiration and ATP) increased in 4-10 week-old BALB/c mice infected with respiratory syncytial virus (RSV). This study examined the kinetics and changes in cellular bioenergetics in ≤ 2-week-old C57BL/6 mice following RSV infection. Mice (5-14 days old) were inoculated intranasally with RSV and the lungs were examined on days 1-10 post-infection. Histopathology and electron microscopy revealed preserved pneumocyte architectures and organelles. Increased lung cellular bioenergetics was noted from days 1-10 post-infection. Cellular GSH remained unchanged. These results indicate that the increased lung cellular respiration (measured by mitochondrial O2 consumption) and ATP following RSV infection is independent of either age or genetic background of the host.
authors.affiliation: Departments of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates. Electronic address: alsuwaidia@uaeu.ac.ae.
authors.forename: Ahmed R
authors.initials: AR
authors.lastname: Alsuwaidi
authors.affiliation: Departments of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates. Electronic address: alia.albawardi@uaeu.ac.ae.
authors.forename: Alia
authors.initials: A
authors.lastname: Albawardi
authors.affiliation: Departments of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates. Electronic address: saeeda.almarzooqi@uaeu.ac.ae.
authors.forename: Saeeda
authors.initials: S
authors.lastname: Almarzooqi
authors.affiliation: Departments of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates. Electronic address: sheela.benedict@uaeu.ac.ae.
authors.forename: Sheela
authors.initials: S
authors.lastname: Benedict
authors.affiliation: Departments of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates. Electronic address: aws.rashad@uaeu.ac.ae.
authors.forename: Aws R
authors.initials: AR
authors.lastname: Othman
authors.affiliation: Department of Microbiology, Department of Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: stacey-hartwig@uiowa.edu.
authors.forename: Stacey M
authors.initials: SM
authors.lastname: Hartwig
authors.affiliation: Department of Microbiology, Department of Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: steven-varga@uiowa.edu.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Varga
authors.affiliation: Departments of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates. Electronic address: asouid@uaeu.ac.ae.
authors.forename: Abdul-Kader
authors.initials: AK
authors.lastname: Souid
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D000831:Animals, Newborn; D004734:Energy Metabolism; D006651:Histocytochemistry; D008168:Lung / Q000503:physiopathology* / Q000821:virology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D010101:Oxygen Consumption; D018357:Respiratory Syncytial Virus Infections / Q000503:physiopathology* / Q000821:virology*; D012136:Respiratory Syncytial Viruses / Q000502:physiology*
chemical_list: D000255:Adenosine Triphosphate
keywords: C57BL/6; Cellular ATP; Cellular respiration; Mice; Mitochondria; Neonates; Oxygen consumption; Respiratory syncytial virus