title: The efficacy of Yunnan Baiyao on haemostasis and antiulcer: a systematic review and meta-analysis of randomized controlled trials.
abstract: Yunnan Baiyao (YNBY) is widely used to treat rhexis haemorrhage and ulcer in China. This meta-analysis was conducted to determine the efficacy of YNBY on local haemostasis and antiulcer. Randomized controlled trials were included on condition that assessing the effects of YNBY with/without routine drugs versus the same routine drugs on haemorrhage or ulcer after searching major databases. Data were validated, extracted and synthesized using relative risk (RR) for dichotomous data using random effects models. Fifty-five studies involving 5,150 patients were identified. (1) YNBY alone for haemorrhage (RR = 1.16; 95% CI 1.06 to 1.28) (2) YNBY alone for antiulcer (RR = 1.26; 95% CI 1.03 to 1.53). We found certain effects on ulcerative colitis (RR = 1.22) and skin ulcer (RR = 1.20) in subgroup analysis. (3) YNBY plus routine haemostatic drugs for haemorrhage (RR = 1.23; 95% CI 1.17 to 1.29) with a significant funnel plot asymmetry (Begg's test, p = 0). (4) YNBY plus routine antiulcer drugs for antiulcer (RR = 1.18; 95% CI 1.05 to 1.33). Treatment effect in the 2(nd) and 4(th) group was unstable when RCTs at high risk of bias were excluded. Great heterogeneities and possible publication bias were found among the trials which preclude certain conclusions. The existing data showed that YNBY alone was helpful in treating uterine haemorrhage, ulcerative colitis and skin ulcer. YNBY plus routine antiulcer drugs was more effective in treating ulcerative colitis versus antiulcer drugs alone.
authors.affiliation: Kidney Institute of CPLA, Division of Nephrology, Changzheng Hospital, Second Military Medical University Shanghai 200003, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: No. 9 Cadets Company, Graduate Administration Division; Second Military Medical University Shanghai 200433, China.
authors.forename: Zhe-Qi
authors.initials: ZQ
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University Shanghai 200003, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University Shanghai 200003, China.
authors.forename: Feng-Ying
authors.initials: FY
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University Shanghai 200003, China.
authors.forename: Xue-Yin
authors.initials: XY
authors.lastname: Shi
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University Shanghai 200003, China.
authors.forename: Zui
authors.initials: Z
authors.lastname: Zou
authors.affiliation: Department of Traditional Chinese Medicine, Changhai Hospital Second Military Medical University Shanghai 200433, China.
authors.forename: Chang-Quan
authors.initials: CQ
authors.lastname: Ling
authors.affiliation: Department of Traditional Chinese Medicine, Changhai Hospital Second Military Medical University Shanghai 200433, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Tang
keywords: Yunnan Baiyao; haemorrhage; meta-analysis; ulcer
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