title: Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease.
abstract: In this paper we report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease. The compounds show excellent results as acetylcholinesterase inhibitors, being as active as the standard drug. All these compounds also show very good antioxidant activity through different mechanisms of action.
authors.affiliation: Laboratorio de Sintese de Substancias de Selenio Bioativas, Centro de Ciencias Fisicas e Matematicas, Departamento de Quimica, Universidade Federal de Santa Catarina, 88040-900, Florianopolis, SC, Brazil. braga.antonio@ufsc.br.
authors.forename: Rômulo F S
authors.initials: RF
authors.lastname: Canto
authors.forename: Flavio A R
authors.initials: FA
authors.lastname: Barbosa
authors.forename: Vanessa
authors.initials: V
authors.lastname: Nascimento
authors.forename: Aldo S
authors.initials: AS
authors.lastname: de Oliveira
authors.forename: Inês M C
authors.initials: IM
authors.lastname: Brighente
authors.forename: Antonio Luiz
authors.initials: AL
authors.lastname: Braga
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000975:Antioxidants / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D058990:Molecular Targeted Therapy; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012643:Selenium / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D011744:Pyrimidinones; D012643:Selenium