title: Optical imaging of brain activation in Gambian infants.
abstract: We used optical topography (OT) to investigate cognitive function in infants in rural Gambia. Images of changes in oxyhaemoglobin and deoxyhaemoglobin concentrations were reconstructed using a multispectral algorithm which uses the finite element method (FEM) to model the propagation of light through scattering tissue using the diffusion equation. High quality OT data enabled us to reconstruct images with robust representation of haemodynamic changes. OT is a feasible neuroimage technology for this resource-poor setting.
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, Malet Place Engineering Building, London, WC1E 6BT, UK. m.papademetriou@ucl.ac.uk.
authors.forename: Marie D
authors.initials: MD
authors.lastname: Papademetriou
authors.affiliation: Centre for Brain and Cognitive Development, Birkbeck, University of London, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Lloyd-Fox
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, Malet Place Engineering Building, London, WC1E 6BT, UK.
authors.forename: N L
authors.initials: NL
authors.lastname: Everdell
authors.affiliation: MRC International Nutrition Group, MRC Keneba, Keneba, The Gambia.
authors.forename: M K
authors.initials: MK
authors.lastname: Darboe
authors.affiliation: MRC International Nutrition Group, MRC Keneba, Keneba, The Gambia.|MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: S E
authors.initials: SE
authors.lastname: Moore
authors.affiliation: MRC International Nutrition Group, MRC Keneba, Keneba, The Gambia.|MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Prentice
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, Malet Place Engineering Building, London, WC1E 6BT, UK.
authors.forename: C E
authors.initials: CE
authors.lastname: Elwell
mesh_terms: D000465:Algorithms; D001921:Brain / Q000502:physiology*; D020342:Finite Element Analysis; D005714:Gambia; D006801:Humans; D007223:Infant; D019265:Spectroscopy, Near-Infrared