title: On the mucoadhesive properties of chitosan-coated polycaprolactone nanoparticles loaded with curcumin using quartz crystal microbalance with dissipation monitoring.
abstract: Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D) was used to investigate the mucoadhesive properties of nanoparticles decorated with low, medium and high molar mass chitosan (CS). Uncoated and chitosan-coated polycaprolactone (PCL) nanoparticles loaded with curcumin were prepared by nanoprecipitation method and characterized in terms of size, surface charge and drug content. The interactions between nanoparticles and mucin layer were monitored after the treatment of SAM-functionalized gold-coated quartz crystals with bovine submaxillary gland mucin (BSM). The results show that all investigated chitosan-coated nanoparticles adsorb onto the BSM layer, and the mass uptake was found to be independent of the chitosan molar mass. Uncoated nanoparticles showed, however, no affinity with BSM layer, confirming that the adsorption of colloidal systems occurs due to their decoration with chitosan. The adhesion is mainly attributed to electrostatic interactions between protonated amino groups of mucoadhesive chitosan and negatively charged groups of mucin. The results suggest that chitosan-coated nanoparticles are promising carriers for hydrophobic drugs delivery in the buccal mucosa.
authors.forename: Letícia
authors.initials: L
authors.lastname: Mazzarino
authors.forename: Liliane
authors.initials: L
authors.lastname: Coche-Guérente
authors.forename: Pierre
authors.initials: P
authors.lastname: Labbé
authors.forename: Elenara
authors.initials: E
authors.lastname: Lemos-Senna
authors.forename: Redouane
authors.initials: R
authors.lastname: Borsali
mesh_terms: D000268:Adhesiveness; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry; D002417:Cattle; D048271:Chitosan / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry*; D004735:Energy Transfer; D008422:Materials Testing; D055617:Micro-Electrical-Mechanical Systems / Q000379:methods; D009061:Mouth Mucosa / Q000737:chemistry*; D009077:Mucins / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry*; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D000970:Antineoplastic Agents; D020099:Coated Materials, Biocompatible; D009077:Mucins; D053769:Nanocapsules; D011091:Polyesters; C016240:polycaprolactone; D048271:Chitosan; D003474:Curcumin