title: Association of APOE polymorphisms and stressful life events with dementia in a Pakistani population.
abstract: Dementia is a major public health problem worldwide. Alzheimer's disease (AD) is a major form of dementia and the APOE 4 allele is an established genetic risk factor for AD. Similarly, stressful life events are also associated with dementia. The objective of this study was to examine the association of APOE 4 and stressful life events with dementia in a Pakistani sample, which to our knowledge has not been reported previously. We also tested for an interaction between stressful life events and APOE 4 on dementia risk. A total of 176 subjects (61 cases and 115 controls) were recruited. All cases and healthy controls were interviewed to assess cognition, co-morbidities, history of stressful life events and demographics. Blood genotyping for the APOE polymorphism (E2/E3/E4) was performed. APOE 4 and stressful life events were each independently and significantly associated with the risk of dementia (APOE 4: P=0.00697; stressful life events: P=5.29E-09). However, we did not find a significant interaction between APOE 4 carrier status and stressful life events on risk of dementia (P=0.677). Although the sample size of this study was small, the established association of APOE 4 with dementia was confirmed the first time in a Pakistani sample. Furthermore, stressful life events were also found to be significantly associated with dementia in this population.
authors.affiliation: Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan. Electronic address: mac321@pitt.edu.
authors.forename: M
authors.initials: M
authors.lastname: Chaudhry
authors.affiliation: Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan; The Women University Multan, Multan, Pakistan.
authors.forename: S
authors.initials: S
authors.lastname: Hasnain
authors.affiliation: Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: B E
authors.initials: BE
authors.lastname: Snitz
authors.affiliation: Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Rosenthal
authors.affiliation: Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: F Y
authors.initials: FY
authors.lastname: Demirci
authors.affiliation: Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: M I
authors.initials: MI
authors.lastname: Kamboh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D003704:Dementia / Q000209:etiology / Q000235:genetics* / Q000523:psychology; D004198:Disease Susceptibility; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008016:Life Change Events; D008297:Male; D010154:Pakistan; D011110:Polymorphism, Genetic; D013315:Stress, Psychological / Q000150:complications* / Q000523:psychology
chemical_list: D001057:Apolipoproteins E
keywords: APOE; Dementia; Pakistan; Stressful life events
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