title: Survey of the occurrence of pharmaceuticals in Spanish finished drinking waters.
abstract: Fifty samples of finished drinking waters (FDWs) from Spain covering 12 million inhabitants were tested for 53 pharmaceuticals pertaining to 12 different Anatomical Therapeutic Chemical (ATC) classification system codes. The studied compounds are a combination of most commonly consumed pharmaceuticals with other barely reported in the literature. Five compounds, azithromycin, clarithromycin, erythromycin, sulfamethoxazole, and ibuprofen were tentatively identified by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in some samples (2 to 15 %), but only ibuprofen and azithromycin could be confirmed when analyzed by liquid chromatography-high-resolution mass spectrometry (LC-HRMS) with a quadrupole-Orbitrap instrument. Concentration levels of ibuprofen in the positive samples ranged from 12 to 17 ng/L (n = 6) while for azithromycin values from 5 to 9.5 ng/L (n = 3) were found. Ibuprofen fragmentation behaviour in different mass spectrometry instrument configurations (triple quadrupole, quadrupole-ion trap, and quadrupole-Orbitrap) was evaluated.
authors.affiliation: Aigües de Barcelona, S.A. General Batet 5-7, 08028, Barcelona, Spain.
authors.forename: M Rosa
authors.initials: MR
authors.lastname: Boleda
authors.forename: Elida
authors.initials: E
authors.lastname: Alechaga
authors.forename: Encarnación
authors.initials: E
authors.lastname: Moyano
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Galceran
authors.forename: Francesc
authors.initials: F
authors.lastname: Ventura
mesh_terms: D017963:Azithromycin / Q000032:analysis; D002853:Chromatography, Liquid / Q000379:methods; D017291:Clarithromycin / Q000032:analysis; D060766:Drinking Water / Q000737:chemistry*; D004784:Environmental Monitoring / Q000379:methods / Q000706:statistics & numerical data*; D004917:Erythromycin / Q000032:analysis; D007052:Ibuprofen / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013030:Spain; D013420:Sulfamethoxazole / Q000032:analysis; D053719:Tandem Mass Spectrometry / Q000379:methods; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D060766:Drinking Water; D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical; D004917:Erythromycin; D017963:Azithromycin; D017291:Clarithromycin; D013420:Sulfamethoxazole; D007052:Ibuprofen
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