title: Advances in research of the neuroprotective mechanisms of cerebral ischemic postconditioning.
abstract: Ischemic postconditioning refers to controlling reperfusion blood flow during reperfusion after ischemia, which can induce an endogenous neuroprotective effect and reduce ischemia-reperfusion injury. Activation of endogenous neuroprotective mechanisms plays a key role in protecting against brain ischemia-reperfusion injury. The mechanisms of cerebral ischemic postconditioning are not completely clear, and the following aspects may be involved: downregulation of oxidative stress, attenuating mitochondrial dysfunction, attenuating endoplasmic reticulum stress, accelerating the elimination of glutamate, increasing rCBF, inhibiting apoptosis, inhibiting autophagy, and regulating signal transduction.
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital of Medical School of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Ma
authors.forename: Jin-Ning
authors.initials: JN
authors.lastname: Song
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Ji-Yang
authors.initials: JY
authors.lastname: An
authors.forename: Yong-Lin
authors.initials: YL
authors.lastname: Zhao
authors.forename: Bin-Fei
authors.initials: BF
authors.lastname: Zhang
mesh_terms: D000818:Animals; D035843:Biomedical Research; D002545:Brain Ischemia / Q000150:complications; D006801:Humans; D057775:Ischemic Postconditioning / Q000379:methods*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000209:etiology / Q000517:prevention & control*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D018696:Neuroprotective Agents
keywords: cerebral ischemia; ischemia-reperfusion injury; ischemic postconditioning