title: Effects of prenatal propofol exposure on postnatal development in rats.
abstract: Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive continuous infusion of saline (control) or propofol for 1 h (1HP) or 2 h (2HP) on gestational day 18. An additional group (lipid) was assigned to receive continuous infusion of intralipid fat emulsion (vehicle of propofol) for 2 h. Pups were then tested on the appearance and progression of sensory and physical motor abilities between postnatal day 1 (P1) and P28. The brain and body weights of pups from 2HP group on P10 were significantly lower than those from the saline control group, although they were the same in all four groups at birth (P0). Pups from 1HP and 2HP groups, but not lipid group, showed slower maturation of eyes (delayed opening) and several neurological reflexes (hindlimb reflex, righting reflex); they also showed delayed improvement in execution on gait reflex and inclined board tests. The forelimb reflex and negative geotaxis were also delayed in 2HP group. All parameters examined except body weight of 2HP pups recovered to normal levels by P28. We conclude that administration of propofol to pregnant rats leads to retardation in physical and neurological reflex development in their offspring.
authors.affiliation: Department of Anesthesiology, Rutgers-New Jersey Medical School, Newark, NJ, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Rutgers-New Jersey Medical School, Newark, NJ, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Xiong
authors.affiliation: Department of Anesthesiology, Rutgers-New Jersey Medical School, Newark, NJ, USA.
authors.forename: Hussain M
authors.initials: HM
authors.lastname: Alhashem
authors.affiliation: Department of Anesthesiology, Rutgers-New Jersey Medical School, Newark, NJ, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Rutgers-New Jersey Medical School, Newark, NJ, USA.
authors.forename: Vasanti
authors.initials: V
authors.lastname: Tilak
authors.affiliation: Department of Anesthesiology, Rutgers-New Jersey Medical School, Newark, NJ, USA.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Patel
authors.affiliation: Department of Psychiatry, Rutgers-New Jersey Medical School, Newark, NJ, USA.
authors.forename: Allan
authors.initials: A
authors.lastname: Siegel
authors.affiliation: Department of Anesthesiology, Rutgers-New Jersey Medical School, Newark, NJ, USA.
authors.forename: Jiang Hong
authors.initials: JH
authors.lastname: Ye
authors.affiliation: Department of Anesthesiology, Rutgers-New Jersey Medical School, Newark, NJ, USA. Electronic address: bekkeray@njms.rutgers.edu.
authors.forename: Alex
authors.initials: A
authors.lastname: Bekker
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001784:Blood Gas Analysis; D002658:Developmental Disabilities / Q000209:etiology*; D004195:Disease Models, Animal; D005260:Female; D006993:Hypnotics and Sedatives / Q000633:toxicity*; D008297:Male; D008425:Maternal Behavior; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000503:physiopathology*; D015742:Propofol / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012018:Reflex / Q000502:physiology; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol
keywords: Neurobehavioral development; Prenatal exposure; Propofol; Reflex