title: Development of mammalian ovary.
abstract: Pre-natal and early post-natal ovarian development has become a field of increasing importance over recent years. The full effects of perturbations of ovarian development on adult fertility, through environmental changes or genetic anomalies, are only now being truly appreciated. Mitigation of these perturbations requires an understanding of the processes involved in the development of the ovary. Herein, we review some recent findings from mice, sheep, and cattle on the key events involved in ovarian development. We discuss the key process of germ cell migration, ovigerous cord formation, meiosis, and follicle formation and activation. We also review the key contributions of mesonephric cells to ovarian development and propose roles for these cells. Finally, we discuss polycystic ovary syndrome, premature ovarian failure, and pre-natal undernutrition; three key areas in which perturbations to ovarian development appear to have major effects on post-natal fertility.
authors.affiliation: AgResearch InvermayPuddle Alley, Mosgiel 9053, New ZealandDepartment of AnatomyUniversity of Otago, Dunedin 9054, New ZealandDepartment of Anatomy and Developmental BiologyMonash University, Clayton, Victoria 3800, AustraliaRobinson Research InstituteDiscipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, AustraliaAgResearch InvermayPuddle Alley, Mosgiel 9053, New ZealandDepartment of AnatomyUniversity of Otago, Dunedin 9054, New ZealandDepartment of Anatomy and Developmental BiologyMonash University, Clayton, Victoria 3800, AustraliaRobinson Research InstituteDiscipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia peter.smith@agresearch.co.nz.
authors.forename: Peter
authors.initials: P
authors.lastname: Smith
authors.affiliation: AgResearch InvermayPuddle Alley, Mosgiel 9053, New ZealandDepartment of AnatomyUniversity of Otago, Dunedin 9054, New ZealandDepartment of Anatomy and Developmental BiologyMonash University, Clayton, Victoria 3800, AustraliaRobinson Research InstituteDiscipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Wilhelm
authors.affiliation: AgResearch InvermayPuddle Alley, Mosgiel 9053, New ZealandDepartment of AnatomyUniversity of Otago, Dunedin 9054, New ZealandDepartment of Anatomy and Developmental BiologyMonash University, Clayton, Victoria 3800, AustraliaRobinson Research InstituteDiscipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia.
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Rodgers
mesh_terms: D000818:Animals; D002417:Cattle; D002465:Cell Movement / Q000502:physiology*; D005260:Female; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010049:Ovarian Diseases / Q000196:embryology / Q000503:physiopathology; D010053:Ovary / Q000166:cytology / Q000196:embryology* / Q000502:physiology*; D012756:Sheep
keywords: development; fetus; ovary; polycystic ovary syndrome; premature ovary failure