title: [Interdigitating dendritic cell sarcoma/tumor: a clinicopathologic study].
abstract: OBJECTIVE
  To study the clinicopathologic characteristics and diagnostic criteria of interdigitating dendritic cell sarcoma/tumor (IDCS/T).
  
  
  METHODS
  The clinical features, histologic findings and results of immunohistochemical study in six cases of IDCS/T were analyzed, with review of literature.
  
  
  RESULTS
  The age of patients ranged from 20 to 68 years. The sites of involvement included lymph node, tonsil and soft tissue. Histologically, the tumor cells were arranged in sheets, fascicles or whorls and intimately admixed with abundant lymphocytes and plasma cells. They were oval to spindly in shape and contained pale eosinophilic cytoplasm, oval nuclei and distinct nucleoli.Immunohistochemical study showed that the tumor cells were positive for S-100 protein and CD68.
  
  
  CONCLUSIONS
  IDCS/T is a rare malignant tumor with poor prognosis. It carries distinctive histologic pattern and immunophenotype. The entity needs to be distinguished from follicular dendritic cell sarcoma/tumor, anaplastic large cell lymphoma and other spindle cell sarcomas in occurring soft tissue.
authors.affiliation: Department of Pathology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Minhong
authors.initials: M
authors.lastname: Pan
authors.affiliation: Department of Pathology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Qixing
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Department of Pathology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Qinhe
authors.initials: Q
authors.lastname: Fan
authors.affiliation: Department of Pathology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Pathology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pathology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China. E-mail:cc2659@sina.com.
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D054740:Dendritic Cell Sarcoma, Follicular / Q000378:metabolism / Q000473:pathology; D054739:Dendritic Cell Sarcoma, Interdigitating / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D051677:Histiocytoma, Malignant Fibrous / Q000378:metabolism / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009333:Neck; D009418:S100 Proteins / Q000378:metabolism; D012509:Sarcoma / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology*; D013848:Thigh; D014067:Tonsillar Neoplasms / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000378:metabolism; D055815:Young Adult; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule