title: Mild and phosphine-free iron-catalyzed cross-coupling of nonactivated secondary alkyl halides with alkynyl Grignard reagents.
abstract: A simple protocol for iron-catalyzed cross-coupling of nonactivated secondary alkyl bromides and iodides with alkynyl Grignard reagents at room temperature has been developed. A wide range of secondary alkyl halides and terminal alkynes are tolerated to afford the substituted alkynes in good yields. A slight modification of the reaction protocol also allows for cross-coupling with a variety of primary alkyl halides.
authors.affiliation: Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytecnique Fédérale de Lausanne (EPFL), ISIC-LSCI , BCH 3305, Lausanne 1015, Switzerland.
authors.forename: Chi Wai
authors.initials: CW
authors.lastname: Cheung
authors.forename: Peng
authors.initials: P
authors.lastname: Ren
authors.forename: Xile
authors.initials: X
authors.lastname: Hu