title: Biopolymer-based supramolecular micelles from β-cyclodextrin and methylcellulose.
abstract: Supramolecular polymer micelles (SMPMs) were constructed from natural and natural-derived polymers: β-cyclodextrin (β-CD)/maleic anhydride modified β-cyclodextrin (MAh-β-CD) and methylcellulose (MC) in aqueous solution by one-pot self-assembly procedure, in which, β-CD and MAh-β-CD inclusion complexes were used as the hydrophilic shell and the free MC as the core. The shapes of the SMPMs were regular spheres with diameters of 25±5 nm. The critical micelle concentrations, calculated from steady-state fluorescence emission spectra, were around 15.13 and 20.89 mg/L for MC/β-CD and MC/MAh-β-CD SMPMs, respectively. The in vitro drug release behaviors of the micelles were studied using prednisone acetate as a model drug, and the results showed that the MC/MAh-β-CD micelle had a drug-enrichment core and excellent drug released behaviors with a sustaining release time of 700 h.
authors.affiliation: Department of Polymer Science, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
authors.forename: Jiaojiao
authors.initials: J
authors.lastname: Du
authors.forename: Xin
authors.initials: X
authors.lastname: Guo
authors.forename: Jiaxing
authors.initials: J
authors.lastname: Tu
authors.forename: Longqiang
authors.initials: L
authors.lastname: Xiao
authors.forename: Xiangxiang
authors.initials: X
authors.lastname: Jia
authors.forename: Liqiong
authors.initials: L
authors.lastname: Liao
authors.forename: Lijian
authors.initials: L
authors.lastname: Liu
mesh_terms: D001704:Biopolymers / Q000737:chemistry*; D008747:Methylcellulose / Q000737:chemistry*; D008823:Micelles; D014961:X-Ray Diffraction / Q000379:methods; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D001704:Biopolymers; D008823:Micelles; D047392:beta-Cyclodextrins; D008747:Methylcellulose; C031215:betadex