title: Infection and HLA-G molecules in nasal polyposis.
abstract: Sinonasal polyposis (SNP) is a chronic inflammatory pathology with an unclear aetiopathogenesis. Human papillomavirus (HPV) infection is one candidate for the development of SNP for its epithelial cell trophism, hyperproliferative effect, and the induction of immune-modulatory molecules as HLA-G. We enrolled 10 patients with SNP without concomitant allergic diseases (SNP-WoAD), 10 patients with SNP and suffering from allergic diseases (SNP-WAD), and 10 control subjects who underwent rhinoplasty. We analyzed the presence of high- and low-risk HPV DNA and the expression of membrane HLA-G (mHLA-G) and IL-10 receptor (IL-10R) and of soluble HLA-G (sHLA-G) and IL-10 by polyp epithelial cells. The results showed the presence of HPV-11 in 50% of SNP-WoAD patients (OR:5.5), all characterized by a relapsing disease. HPV-11 infection was absent in nonrelapsing SNP-WoAD patients, in SNP-WAD patients and in controls, supporting the hypothesis that HPV-11 increases risk of relapsing disease. HPV-11 positive SNP-WoAD patients presented with mHLA-G and IL-10R on epithelial cells from nasal polyps and showed secretion of sHLA-G and IL-10 in culture supernatants. No HLA-G expression was observed in HPV negative polyps. These data highlight new aspects of polyposis aetiopathogenesis and suggest HPV-11 and HLA-G/IL-10 presence as prognostic markers in the follow-up of SNP-WoAD.
authors.affiliation: Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Via Luigi Borsari, 46, 44121 Ferrara, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Rizzo
authors.affiliation: Operative Unit of Otolaryngology, St. Anna Hospital, Via A. Moro, 844124 Ferrara, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Malagutti
authors.affiliation: Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Via Luigi Borsari, 46, 44121 Ferrara, Italy.
authors.forename: Daria
authors.initials: D
authors.lastname: Bortolotti
authors.affiliation: Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Via Luigi Borsari, 46, 44121 Ferrara, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Gentili
authors.affiliation: Operative Unit of Otolaryngology, St. Anna Hospital, Via A. Moro, 844124 Ferrara, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Rotola
authors.affiliation: Operative Unit of Neuroradiology, St. Anna Hospital, Via A. Moro, 844124 Ferrara, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Fainardi
authors.affiliation: Operative Unit of Otolaryngology, St. Anna Hospital, Via A. Moro, 844124 Ferrara, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Pezzolo
authors.affiliation: Operative Unit of Otolaryngology, St. Anna Hospital, Via A. Moro, 844124 Ferrara, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Aimoni
authors.affiliation: Operative Unit of Otolaryngology, St. Anna Hospital, Via A. Moro, 844124 Ferrara, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Pelucchi
authors.affiliation: Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Via Luigi Borsari, 46, 44121 Ferrara, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Di Luca
authors.affiliation: Operative Unit of Otolaryngology, St. Anna Hospital, Via A. Moro, 844124 Ferrara, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pastore
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D059951:HLA-G Antigens / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D052140:Human papillomavirus 11; D006801:Humans; D007239:Infections / Q000150:complications*; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000821:virology; D009298:Nasal Polyps / Q000209:etiology* / Q000473:pathology; D030361:Papillomavirus Infections / Q000150:complications; D053701:Receptors, Interleukin-10 / Q000378:metabolism
chemical_list: D059951:HLA-G Antigens; D053701:Receptors, Interleukin-10; D016753:Interleukin-10
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