title: Phase 1 dose escalation and pharmacokinetic evaluation of oral gemcitabine prodrug (LY2334737) in combination with docetaxel in patients with advanced solid tumors.
abstract: OBJECTIVE
  This Phase 1 study aimed to determine the recommended Phase 2 dose of LY2334737, an oral gemcitabine prodrug, when combined with standard dose docetaxel treatment in patients with advanced solid tumors. Pharmacokinetics (PK) and antitumor activity were additionally evaluated.
  
  
  METHODS
  Patients with advanced/metastatic solid tumors received escalating doses of LY2334737 once daily (QD) for 14 days, followed by a 7-day drug-free period. Docetaxel was given at 75 mg/m(2) every 3 weeks (q3w). Cycles were repeated until progressive disease (PD) or unacceptable toxicity.
  
  
  RESULTS
  Of 22 patients recruited, all Caucasian, 7 received an LY2334737 dose of 10 mg/day, 10 received 20 mg/day, 5 received 30 mg/day. Nineteen patients discontinued due to PD, 2 due to adverse events, 1 due to investigator decision. Dose-limiting toxicities: 2× febrile neutropenia (G3), 2× fatigue (1× G2, 1× G3), 1× neutropenia (G4). The maximum tolerated dose (MTD) was identified to be 10 mg/day. Two patients achieved partial response, 10 patients stable disease. Enrollment was stopped after unexpected hepatic toxicities were observed with LY2334737 QD for 14 days per cycle in another study of Japanese patients. PK data were consistent with the first-in-man study of LY2334737 and did not reveal any drug-drug interaction between LY2334737 and docetaxel.
  
  
  CONCLUSIONS
  Combination of LY2334737 at doses up to 30 mg/day QD for 14 days per cycle with docetaxel 75 mg/m(2) q3w resulted in an undesirable toxicity profile and a low MTD of 10 mg/day. Alternative treatment schedules of LY2334737 should be explored.
authors.affiliation: Clinical Research Unit, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Ctra. Gran Vía, 08907 s/n., Barcelona, Spain, ramon.salazar.soler@gmail.com.
authors.forename: Ramon
authors.initials: R
authors.lastname: Salazar
authors.forename: Serafin
authors.initials: S
authors.lastname: Morales
authors.forename: Marta
authors.initials: M
authors.lastname: Gil-Martín
authors.forename: Elena
authors.initials: E
authors.lastname: Aguirre
authors.forename: Ana
authors.initials: A
authors.lastname: Oaknin
authors.forename: Margarita
authors.initials: M
authors.lastname: Garcia
authors.forename: Sophie
authors.initials: S
authors.lastname: Callies
authors.forename: Enaksha R
authors.initials: ER
authors.lastname: Wickremsinhe
authors.forename: Karim A
authors.initials: KA
authors.lastname: Benhadji
authors.forename: Antonio
authors.initials: A
authors.lastname: Llombart
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D003857:Deoxyuridine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D000077143:Docetaxel; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D011355:Prodrugs / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: C569272:LY2334737; D011355:Prodrugs; D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; D003857:Deoxyuridine; D000093542:Gemcitabine