title: Primary low-grade diffuse small lymphocytic lymphoma of the central nervous system.
abstract: A 45-year-old Indian woman presented in neurosurgery outpatient with seizures, headache and vomiting for the past 1 month. MRI of the brain was suggestive of a malignant central nervous system (CNS) tumour. Histological and immunohistochemical examinations of stereotactic biopsy of the tumour were diagnostic of a low-grade diffuse small lymphocytic lymphoma of the CNS. No evidence of any occult systemic lymphoma was observed, confirming its 'primary' origin in the CNS. The diagnosis of a low-grade primary CNS lymphoma (PCNSL) is difficult as clinical and neuroradiological features are wide and variable. The clinical course is more indolent than a high-grade PCNSL and thus, a less aggressive and localised targeted treatment could be sufficient rather than the high dose, neurotoxic methotrexate-based chemotherapeutic treatment, recommended for high-grade PCNSL. Histological and immunohistological confirmation is therefore mandatory for early, appropriate treatment and prognostic implications.
authors.affiliation: Department of Pathology, Jawaharlal Nehru Medical College (JNMC), Aligarh Muslim University (AMU), Aligarh, Uttar Pradesh, India.
authors.forename: Mehar
authors.initials: M
authors.lastname: Aziz
authors.forename: Jai Kumar
authors.initials: JK
authors.lastname: Chaurasia
authors.forename: Roobina
authors.initials: R
authors.lastname: Khan
authors.forename: Nishat
authors.initials: N
authors.lastname: Afroz
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged
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