title: [Radiotherapy as conservative therapy for sarcomas within the irradiated field].
abstract: OBJECTIVE
  To describe long-term outcome after combined-modality treatment including radiation therapy in patients with localized sarcoma within irradiated field.
  
  
  METHODS
  Individual clinical data from all consecutive patients diagnosed and treated for a localized sarcoma within irradiated field between January 2000 and October 2011 at the Institut Claudius-Regaud, Toulouse, France, were retrospectively reviewed.
  
  
  RESULTS
  Twenty-seven patients were eligible for this study. Ten patients were re-irradiated with a rate of unresectable, gross or microscopically positive margins disease significantly higher than the rest of the cohort (90% vs. 12%; P<0.001). After a median follow-up of 3.8 years, there is a non-significant trend toward longer 4-year relapse free survival in the subgroup of patients who received adjuvant or definitive radiation therapy compared to the rest of the cohort (53% vs. 27%; P=0.09) with an acceptable toxicity profile allowing conservative management.
  
  
  CONCLUSIONS
  The complete surgical resection sarcoma within irradiated field is often difficult to achieve enhancing the risk of relapse. Radiation therapy should be discussed when faced with an unresectable tumour or after suboptimal surgery as part of intensified local management with a curative intent.
authors.affiliation: Département de radiothérapie, institut Claudius-Regaud, 20-24, rue du Pont-Saint-Pierre, 31000 Toulouse, France. Electronic address: modesto.anouchka@claudiusregaud.fr.
authors.forename: A
authors.initials: A
authors.lastname: Modesto
authors.affiliation: Département de statistiques biomédicales, institut Claudius-Regaud, 20-24, rue du Pont-Saint-Pierre, 31000 Toulouse, France.
authors.forename: T
authors.initials: T
authors.lastname: Filleron
authors.affiliation: Département d'oncologie médicale, institut Claudius-Regaud, 20-24, rue du Pont-Saint-Pierre, 31000 Toulouse, France.
authors.forename: C
authors.initials: C
authors.lastname: Chevreau
authors.affiliation: Département de radiothérapie, institut Gustave-Roussy, 114, rue Édouard-Vaillant, 94805 Villejuif, France.
authors.forename: C
authors.initials: C
authors.lastname: Le Péchoux
authors.affiliation: Département d'anatomie-pathologie, institut Claudius-Regaud, 20-24, rue du Pont-Saint-Pierre, 31000 Toulouse, France.
authors.forename: P
authors.initials: P
authors.lastname: Rochaix
authors.affiliation: Département d'anatomie-pathologie, institut Claudius-Regaud, 20-24, rue du Pont-Saint-Pierre, 31000 Toulouse, France.
authors.forename: S
authors.initials: S
authors.lastname: Le Guellec
authors.affiliation: Département de radiothérapie, institut Claudius-Regaud, 20-24, rue du Pont-Saint-Pierre, 31000 Toulouse, France.
authors.forename: A
authors.initials: A
authors.lastname: Ducassou
authors.affiliation: Département de chirurgie, institut Claudius-Regaud, 20-24, rue du Pont-Saint-Pierre, 31000 Toulouse, France.
authors.forename: D
authors.initials: D
authors.lastname: Gangloff
authors.affiliation: Département de chirurgie, institut Claudius-Regaud, 20-24, rue du Pont-Saint-Pierre, 31000 Toulouse, France.
authors.forename: G
authors.initials: G
authors.lastname: Ferron
authors.affiliation: Département de radiothérapie, institut Claudius-Regaud, 20-24, rue du Pont-Saint-Pierre, 31000 Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Delannes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality / Q000628:therapy; D059248:Chemoradiotherapy; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009381:Neoplasms, Radiation-Induced / Q000401:mortality* / Q000628:therapy*; D010386:Pelvic Neoplasms / Q000401:mortality / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012509:Sarcoma / Q000401:mortality* / Q000628:therapy*; D013899:Thoracic Neoplasms / Q000401:mortality / Q000628:therapy; D055815:Young Adult
keywords: Conservative therapy; Radiation therapy; Radio-induced sarcoma; Radiothérapie; Reirradiation; Ré-irradiation; Sarcome radio-induit; Sequalae; Séquelles; Traitement conservateur