title: Sleep disruption in hematopoietic cell transplantation recipients: prevalence, severity, and clinical management.
abstract: Sleep disruption is common among hematopoietic cell transplant (HCT) recipients, with over 50% of recipients experiencing sleep disruption pre-transplant, with up to 82% of patients experiencing moderate to severe sleep disruption during hospitalization for transplant and up to 43% after transplant. These rates of sleep disruption are substantially higher than what we see in the general population. Although sleep disruption can be distressing to patients and contribute to diminished quality of life, it is rarely discussed during clinical visits. The goal of the current review is to draw attention to sleep disruption and disorders (ie, insomnia, obstructive sleep apnea, restless legs syndrome) as a clinical problem in HCT in order to facilitate patient education, intervention, and research. We identified 35 observational studies published in the past decade that examined sleep disruption or disorders in HCT. Most studies utilized a single item measure of sleep, had small sample size, and included heterogeneous samples of patients. Six studies of the effects of psychosocial and exercise interventions on sleep in HCT have reported no significant improvements. These results highlight the need for rigorous observational and interventional studies of sleep disruption and disorders in HCT recipients..
authors.affiliation: Moffitt Cancer Center, Tampa, Florida. Electronic address: heather.jim@moffitt.org.
authors.forename: Heather S L
authors.initials: HS
authors.lastname: Jim
authors.affiliation: Department of Psychology, University of South Florida, Tampa, Florida.
authors.forename: Bryan
authors.initials: B
authors.lastname: Evans
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.
authors.forename: Jiyeon M
authors.initials: JM
authors.lastname: Jeong
authors.affiliation: Moffitt Cancer Center, Tampa, Florida.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Gonzalez
authors.affiliation: Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, California.
authors.forename: Laura
authors.initials: L
authors.lastname: Johnston
authors.affiliation: Department of Psychology, University of South Florida, Tampa, Florida.
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Nelson
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.
authors.forename: Shelli
authors.initials: S
authors.lastname: Kesler
authors.affiliation: Moffitt Cancer Center, Tampa, Florida.
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Phillips
authors.affiliation: Moffitt Cancer Center, Tampa, Florida; Psychiatry and Legal Medicine PhD Program, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Barata
authors.affiliation: Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, Florida.
authors.forename: Joseph
authors.initials: J
authors.lastname: Pidala
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.
authors.forename: Oxana
authors.initials: O
authors.lastname: Palesh
mesh_terms: D003430:Cross-Sectional Studies; D019337:Hematologic Neoplasms / Q000150:complications / Q000523:psychology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006760:Hospitalization; D006801:Humans; D026741:Physical Therapy Modalities; D011613:Psychotherapy / Q000379:methods; D011788:Quality of Life / Q000523:psychology*; D012148:Restless Legs Syndrome / Q000150:complications / Q000523:psychology / Q000628:therapy*; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000523:psychology / Q000628:therapy*; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications / Q000523:psychology / Q000628:therapy*; D011795:Surveys and Questionnaires; D014184:Transplantation, Homologous
keywords: Hematopoietic cell transplant; Management of sleep disruption; Sleep disruption
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