title: Mentha piperita in nephrotoxicity--a possible intervention to ameliorate renal derangements associated with gentamicin.
abstract: OBJECTIVE
  Free radical generation has a strong role in the pathogenesis of renal damage associated with the use of gentamicin. Therefore, the present study was carried out to evaluate the renoprotective effect of Mentha piperita against gentamicin induced nephrotoxicity.
  
  
  METHODS
  A total of 24 male rabbits were divided into 4 groups receiving normal saline, gentamicin, M. piperita extract and co-therapy of extract and gentamicin respectively. Gentamicin was provided as 80 mg/kg/day intramuscularly and extract was given 200 mg/kg/day orally for a period of 21 days. Serum and urinary biochemical parameters and histological changes were studied for each group. The impact of the extract on the antibacterial action of gentamicin was also evaluated.
  
  
  RESULTS
  Animals treated with gentamicin showed derangements in serum and urinary biochemical parameters. These alterations were reversed by treatment with M. piperita extract. The histological changes showed in gentamicin group were also reverted by treatment with the extract. Further the plant did not influence the efficacy of gentamicin with respect to its antimicrobial properties.
  
  
  CONCLUSIONS
  Co-therapy of M. piperita with gentamicin successfully attenuated biochemical kidney functioning derangements and morphological changes associated with gentamicin.
authors.affiliation: Department of Pharmacy, University of Swabi, Swabi, Pakistan.
authors.forename: Naveed
authors.initials: N
authors.lastname: Ullah
authors.affiliation: University of Malakand, Chakdara, Pakistan.
authors.forename: Mir Azam
authors.initials: MA
authors.lastname: Khan
authors.affiliation: Comsats Institute of Information Technology, Abbottabad, Pakistan.
authors.forename: Taous
authors.initials: T
authors.lastname: Khan
authors.affiliation: Department of Pharmacology, Frontier Medical College, Abbottabad, Pakistan.
authors.forename: Afzal Haq
authors.initials: AH
authors.lastname: Asif
authors.affiliation: University of Malakand, Chakdara, Pakistan.
authors.forename: Waqar
authors.initials: W
authors.lastname: Ahmad
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000633:toxicity*; D005609:Free Radicals / Q000378:metabolism; D005839:Gentamicins / Q000494:pharmacology / Q000633:toxicity*; D041743:Herb-Drug Interactions; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control* / Q000652:urine; D007677:Kidney Function Tests; D008297:Male; D036142:Mentha piperita / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D011817:Rabbits
chemical_list: D000900:Anti-Bacterial Agents; D005609:Free Radicals; D005839:Gentamicins; D010936:Plant Extracts
keywords: Aminoglycosides; Mentha piperita; gentamicin; nephroprotective; peppermint
references.citation: J Lab Clin Med. 1980 Jan;95(1):32-9
references.pmid: 6444232
references.citation: J Lab Clin Med. 1980 Mar;95(3):463-74
references.pmid: 7354245
references.citation: Hum Exp Toxicol. 2001 Apr;20(4):199-203
references.pmid: 11393273
references.citation: Nat Prod Commun. 2009 Apr;4(4):535-42
references.pmid: 19476001
references.citation: Hum Exp Toxicol. 2003 Apr;22(4):213-9
references.pmid: 12755472
references.citation: Planta Med. 2003 May;69(5):413-9
references.pmid: 12802721
references.citation: J Lab Clin Med. 1977 Mar;89(3):622-31
references.pmid: 839119
references.citation: Int Rev Exp Pathol. 1983;24:277-333
references.pmid: 6840997
references.citation: Am J Pathol. 1986 Apr;123(1):183-94
references.pmid: 3963150
references.citation: Toxicol Lett. 1989 Mar;46(1-3):107-23
references.pmid: 2650018
references.citation: Am J Med. 1986 Jun 30;80(6B):172-8
references.pmid: 3524215
references.citation: Mutat Res. 2005 Aug 1;585(1-2):147-55
references.pmid: 16005256
references.citation: Basic Clin Pharmacol Toxicol. 2009 Apr;104(4):329-34
references.pmid: 19320637
references.citation: Eur Rev Med Pharmacol Sci. 2010 Dec;14(12):1011-4
references.pmid: 21375131