title: [Application of desflurane in anaesthesiology].
abstract: Desflurane (Des)--is a modern inhalation anaesthetic available in Russia since August, 2013. Des is a halogenated ether; its chemical structure is 2-difluoromethoxy-1-1-1-2-tetrafluoroethane (C3H2F6O). Special thermocompensated evaporators are used for Des dosing. Low solubility in blood and tissues of an organism causes fast absorption and elimination of Des. Blood/gas distribution ratio of Des is 0.42. Des distinctive properties are high saturated vapor pressure, super short duration of action and average power. Furthermore it is characterized by the minimal metabolism and lack of interaction with soda lime. Des is used for general anesthesia in a cardiac surgery neurosurgery, out-patient surgery, pediatric practice and other areas of surgery. Des has more positive qualities and fewer limitations, than other inhalation anaesthetics (halothane, isoflurane, sevoflurane). High cost of the anaesthetic is compensated by quality and controllability of anaesthesia and reduction of stay time in recovery unit. Fast elimination of the anaesthetic from a body allows reducing a frequency of complications connected with violation of upper airway and hypoxemia, promotes early discontinuation of artificial ventilation, reducing somnolence, earlier restoring a muscular tone in the postoperative period.
authors.forename: D A
authors.initials: DA
authors.lastname: Moshchev
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Lubnin
mesh_terms: D000769:Anesthesia, Inhalation / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D000077335:Desflurane; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D008657:Metabolic Clearance Rate; D009928:Organ Specificity; D014018:Tissue Distribution
chemical_list: D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane