title: Differences in structural elements of Bcr-Abl oncoprotein isoforms in Chronic Myelogenous Leukemia.
abstract: in silico modeling, using Psipred and ExPASy servers was employed to determine the structural elements of Bcr-Abl oncoprotein (p210(BCR-ABL)) isoforms, b2a2 and b3a2, expressed in Chronic Myelogenous Leukemia (CML). Both these proteins are tyrosine kinases having masses of 210-kDa and differing only by 25 amino acids coded by the b3 exonand an amino acidsubstitution (Glu903Asp). The secondary structure elements of the two proteins show differences in five α-helices and nine β-strands which relates to differences in the SH3, SH2, SH1 and DNA-binding domains. These differences can result in different roles played by the two isoforms in mediating signal transduction during the course of CML.
authors.affiliation: Department of Biochemistry, Faculty of Medicine & Applied Medical Sciences, Northern Border University.
authors.forename: Abdul
authors.initials: A
authors.lastname: Hai
authors.affiliation: Department of Biochemistry, Faculty of Medicine & Applied Medical Sciences, Northern Border University.
authors.forename: Nadeem A
authors.initials: NA
authors.lastname: Kizilbash
authors.affiliation: Department of Chemistry, Faculty of Science, Northern Border University, P.O. Box 1321, Arar-91431, Saudi Arabia.
authors.forename: Syeda Huma H
authors.initials: SH
authors.lastname: Zaidi
authors.affiliation: Department of Biochemistry, Faculty of Medicine & Applied Medical Sciences, Northern Border University.
authors.forename: Jamal
authors.initials: J
authors.lastname: Alruwaili
authors.affiliation: Illinois Informatics Institute, University of Illinois, Urbana-Champaign, Illinois, U.S.A.
authors.forename: Khuram
authors.initials: K
authors.lastname: Shahzad
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