title: Three new ring-A modified ursane triterpenes from Davidia involucrata.
abstract: Three new ursane triterpenes, 3α,19α-dihydroxy-2-nor-urs-12-en-23,28-dioic acid-23-methyl ester (1), 19α,23-dihydroxy-3-oxo-2-nor-urs-12-en-28-oic acid (2), and 2,3-seco-3-methoxy-3,19α,23-trihydroxy-urs-12-en-2-al-28-oic acid (3), were isolated from the MeOH extract of the branch barks of Davidia involucrata, together with six known compounds. Their structures were elucidated by means of various spectroscopic analyses. The isolated triterpenes provide important evolutionary and chemotaxonomic knowledge about the monotypic genus Davidia. Five of the identified compounds showed moderate cytotoxicities against the cell proliferation of SGC-7901, MCF-7, and BEL-7404 with IC50 range from 7.26 to 47.41 μM.
authors.affiliation: Key Laboratory of Bio-pesticide and Chemistry-Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China. hotony@163.com.
authors.forename: Qing-Wei
authors.initials: QW
authors.lastname: Tan
authors.affiliation: Key Laboratory of Plant Virology of Fujian Province, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China. maouyang@hqu.edu.cn.
authors.forename: Ming-An
authors.initials: MA
authors.lastname: Ouyang
authors.affiliation: Fujian International Travel Health Care Center, Fuzhou 350001, Fujian, China. gaobo28083@sina.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Gao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D005075:Biological Evolution; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D010802:Phylogeny; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes
references.citation: J Nat Prod. 1994 Feb;57(2):243-7
references.pmid: 8176401
references.citation: J Nat Prod. 1990 May-Jun;53(3):559-64
references.pmid: 2213029
references.citation: Phytochemistry. 2003 Oct;64(4):845-9
references.pmid: 14559279
references.citation: Nat Prod Res. 2008 Apr 15;22(6):483-8
references.pmid: 18415854
references.citation: Nat Prod Res. 2008 Apr 15;22(6):471-6
references.pmid: 18415852
references.citation: Am Nat. 2008 Jan;171(1):119-24
references.pmid: 18171156
references.citation: Nat Prod Rep. 2006 Jun;23(3):394-411
references.pmid: 16741586
references.citation: PLoS One. 2009;4(4):e1
references.pmid: 19399186
references.citation: Phytochemistry. 2002 Feb;59(3):315-23
references.pmid: 11830140
references.citation: J Nat Prod. 2006 Jan;69(1):62-7
references.pmid: 16441070
references.citation: Invest New Drugs. 2011 Apr;29(2):266-72
references.pmid: 19957199
references.citation: Phytochemistry. 2007 Mar;68(6):834-9
references.pmid: 17258248
references.citation: Eur J Med Chem. 2005 Jun;40(6):582-9
references.pmid: 15922841
references.citation: Eur J Pharm Sci. 2006 Sep;29(1):1-13
references.pmid: 16716572
references.citation: Cancer Lett. 2007 Jun 18;251(1):132-45
references.pmid: 17169485
references.citation: Anticancer Drugs. 2010 Mar;21(3):215-27
references.pmid: 20075711
references.citation: Chem Pharm Bull (Tokyo). 2005 Dec;53(12):1594-6
references.pmid: 16327198
references.citation: Bioorg Med Chem Lett. 2010 Jun 1;20(11):3409-12
references.pmid: 20451375
references.citation: Arch Pharm Res. 2000 Apr;23(2):155-8
references.pmid: 10836742
references.citation: J Asian Nat Prod Res. 2007 Sep-Dec;9(6-8):487-92
references.pmid: 17885833
references.citation: Bioorg Med Chem Lett. 2011 Jan 1;21(1):125-9
references.pmid: 21131198