title: Effect of iron status in rats on the absorption of metal ions from plant ferritin.
abstract: An isolate of lead-ferritin obtained from soybean seeds sprouted in 25 mM of PbNO3 was introduced into the diet of both iron-deficient and iron non-deficient male rats. After a 21-day administration period, statistical differences in the lead accumulation in the femurs of the rats were noted. Iron-deficient rats accumulated more than four times the amount of lead in their bones than rats without iron-deficiency. No further decrease was observed in haemoglobin concentrations in the groups of animals fed with lead isolates, either iron-deficient or iron non-deficient. Also, no differences in the mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV) were observed at the end of the experiment in the group of iron non-deficient rats fed with lead-ferritin isolate compared to the control group of iron non-deficient rats. In the iron-deficient group fed with lead-ferritin isolate, a small increase in haemoglobin concentrations, MCH, MCV and mean corpuscular haemoglobin concentrations (MCHC) was recorded. The results presented in this paper confirm that lead from the tested preparation-lead ferritin isolate-was better absorbed by those rats with induced iron deficiency anaemia. Additionally, we may also suspect based on the obtained results that absorption of ferritin-iron depends on iron status in the body.
authors.affiliation: Department of Food Biochemistry and Analysis, Poznań University of Life Sciences, Mazowiecka 48, 60-623, Poznań, Poland, mzd@up.poznan.pl.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zielińska-Dawidziak
authors.forename: Iwona
authors.initials: I
authors.lastname: Hertig
authors.forename: Halina
authors.initials: H
authors.lastname: Staniek
authors.forename: Dorota
authors.initials: D
authors.lastname: Piasecka-Kwiatkowska
authors.forename: Krzysztof W
authors.initials: KW
authors.lastname: Nowak
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000178:diet therapy* / Q000188:drug therapy; D000818:Animals; D004909:Erythrocyte Indices / Q000187:drug effects; D005293:Ferritins / Q000302:isolation & purification / Q000493:pharmacokinetics*; D006454:Hemoglobins / Q000032:analysis; D007408:Intestinal Absorption; D007501:Iron / Q000378:metabolism; D000090463:Iron Deficiencies; D007854:Lead / Q000032:analysis / Q000493:pharmacokinetics; D008297:Male; D010940:Plant Proteins / Q000302:isolation & purification / Q000493:pharmacokinetics*; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D013025:Glycine max / Q000737:chemistry*
chemical_list: D006454:Hemoglobins; D010940:Plant Proteins; D007854:Lead; D005293:Ferritins; D007501:Iron
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