title: A large scale (N=102) functional neuroimaging study of error processing in a Go/NoGo task.
abstract: We report a functional magnetic resonance imaging (fMRI) study of 102 healthy participants who completed a demanding Go/NoGo task. The primary purpose of this study was to delineate the neural systems underlying responses to errors in a large sample. We identified a number of regions engaged during error processing including the anterior cingulate, left lateral prefrontal areas and bilateral inferior frontal gyrus, and the subthalamic nucleus. The power afforded by the large cohort enabled identification of regions not consistently measured during Go/NoGo tasks thus helping to incrementally refine our understanding of the neural correlates of error processing. With the present fMRI results, in combination with our previous exploration of response inhibition (Steele et al.), we outline a comprehensive set of regions associated with both response inhibition and error processing.
authors.affiliation: The Nonprofit Mind Research Network (MRN) & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM 87106, USA; University of New Mexico, Albuquerque, USA. Electronic address: vsteele@mrn.org.
authors.forename: Vaughn R
authors.initials: VR
authors.lastname: Steele
authors.affiliation: The Nonprofit Mind Research Network (MRN) & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM 87106, USA.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Claus
authors.affiliation: The Nonprofit Mind Research Network (MRN) & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM 87106, USA; University of New Mexico, Albuquerque, USA.
authors.forename: Eyal
authors.initials: E
authors.lastname: Aharoni
authors.affiliation: The Nonprofit Mind Research Network (MRN) & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM 87106, USA.
authors.forename: Carla
authors.initials: C
authors.lastname: Harenski
authors.affiliation: The Nonprofit Mind Research Network (MRN) & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM 87106, USA; University of New Mexico, Albuquerque, USA; Yale University School of Medicine, USA.
authors.forename: Vince D
authors.initials: VD
authors.lastname: Calhoun
authors.affiliation: Yale University School of Medicine, USA; Olin Neuropsychiatry Research Center, Institute of Living, USA.
authors.forename: Godfrey
authors.initials: G
authors.lastname: Pearlson
authors.affiliation: The Nonprofit Mind Research Network (MRN) & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM 87106, USA; University of New Mexico, Albuquerque, USA.
authors.forename: Kent A
authors.initials: KA
authors.lastname: Kiehl
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000502:physiology; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology*; D013647:Task Performance and Analysis; D055815:Young Adult
keywords: Error processing; Go/NoGo; Response inhibition; fMRI
references.citation: Brain. 2006 Mar;129(Pt 3):564-83
references.pmid: 16399806
references.citation: J Neurosci. 2006 Mar 1;26(9):2424-33
references.pmid: 16510720
references.citation: Behav Brain Res. 2008 Dec 12;194(2):214-22
references.pmid: 18692526
references.citation: Hum Brain Mapp. 2001 Feb;12(2):100-9
references.pmid: 11169874
references.citation: Nat Neurosci. 2000 May;3(5):516-20
references.pmid: 10769394
references.citation: Psychol Rev. 2002 Oct;109(4):679-709
references.pmid: 12374324
references.citation: Cogn Affect Behav Neurosci. 2012 Jun;12(2):241-68
references.pmid: 22282036
references.citation: Science. 2004 Feb 13;303(5660):1023-6
references.pmid: 14963333
references.citation: Brain Res Cogn Brain Res. 2003 Jul;17(2):419-30
references.pmid: 12880912
references.citation: Neuroimage. 2001 Dec;14(6):1387-401
references.pmid: 11707094
references.citation: Neuroimage. 2009 Aug 15;47(2):442-50
references.pmid: 19442752
references.citation: Hum Brain Mapp. 2008 Nov;29(11):1265-75
references.pmid: 17894392
references.citation: J Cogn Neurosci. 1997 Fall;9(5):648-63
references.pmid: 23965122
references.citation: J Cogn Neurosci. 2007 Jan;19(1):69-80
references.pmid: 17214564
references.citation: IEEE Trans Med Imaging. 2002 May;21(5):470-84
references.pmid: 12071618
references.citation: Neuroimage. 2004 Jun;22(2):879-85
references.pmid: 15193618
references.citation: Biol Psychol. 2003 Oct;64(1-2):119-41
references.pmid: 14602358
references.citation: Neurosci Biobehav Rev. 2009 May;33(5):631-46
references.pmid: 18835296
references.citation: Psychophysiology. 2005 Mar;42(2):151-60
references.pmid: 15787852
references.citation: Neuropsychology. 2002 Oct;16(4):548-61
references.pmid: 12382993
references.citation: CNS Spectr. 2007 Jul;12(7):545-52
references.pmid: 17603406
references.citation: J Neurophysiol. 2007 Dec;98(6):3638-47
references.pmid: 17942624
references.citation: Neuropsychologia. 2008 Jan 15;46(1):224-32
references.pmid: 17850833
references.citation: Neuropsychologia. 2004;42(14):1910-6
references.pmid: 15381021
references.citation: J Neurosci. 2007 Oct 31;27(44):11860-4
references.pmid: 17978025
references.citation: Behav Brain Res. 2013 Nov 1;256:529-36
references.pmid: 23756137
references.citation: Cereb Cortex. 2004 Sep;14(9):986-94
references.pmid: 15115734
references.citation: Neuropsychologia. 2008 Sep;46(11):2668-82
references.pmid: 18573510
references.citation: Hum Brain Mapp. 2001 Mar;12(3):131-43
references.pmid: 11170305
references.citation: Neuroimage. 2012 Jan 16;59(2):1896-903
references.pmid: 21930218
references.citation: Cereb Cortex. 2001 Sep;11(9):825-36
references.pmid: 11532888
references.citation: Neuroimage. 2003 Oct;20(2):1132-9
references.pmid: 14568482
references.citation: Brain Res Cogn Brain Res. 2005 Feb;22(2):221-31
references.pmid: 15653295
references.citation: J Am Acad Child Adolesc Psychiatry. 1997 Mar;36(3):374-83
references.pmid: 9055518
references.citation: Trends Cogn Sci. 2004 Apr;8(4):170-7
references.pmid: 15050513
references.citation: Neuropsychologia. 2009 Dec;47(14):3143-51
references.pmid: 19651151
references.citation: Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15700-5
references.pmid: 16227444
references.citation: Neuroimage. 2006 Apr 1;30(2):544-53
references.pmid: 16246587
references.citation: Biol Psychol. 2008 Oct;79(2):171-8
references.pmid: 18524452
references.citation: Nat Neurosci. 2004 May;7(5):497-8
references.pmid: 15097995
references.citation: Front Psychol. 2011 Sep 15;2:233
references.pmid: 21954390
references.citation: Hum Brain Mapp. 2006 Dec;27(12):973-93
references.pmid: 16683265
references.citation: Biol Psychiatry. 2011 Jun 15;69(12):e55-68
references.pmid: 20932513
references.citation: Hum Brain Mapp. 2009 Jan;30(1):24-37
references.pmid: 17979124
references.citation: Am J Psychiatry. 2004 Sep;161(9):1650-7
references.pmid: 15337656
references.citation: J Neurol Neurosurg Psychiatry. 2004 Apr;75(4):539-44
references.pmid: 15026491
references.citation: Science. 1998 May 1;280(5364):747-9
references.pmid: 9563953
references.citation: Cortex. 2008 May;44(5):580-6
references.pmid: 18387590
references.citation: Neuropsychologia. 2003;41(14):1959-66
references.pmid: 14572528
references.citation: J Cogn Neurosci. 2006 Apr;18(4):651-64
references.pmid: 16768367
references.citation: Brain Res. 2006 Aug 11;1105(1):143-54
references.pmid: 16616048
references.citation: Psychophysiology. 2000 Mar;37(2):216-23
references.pmid: 10731771
references.citation: Neuroscientist. 2007 Jun;13(3):214-28
references.pmid: 17519365
references.citation: Trends Cogn Sci. 2005 Sep;9(9):445-53
references.pmid: 16054861
references.citation: Brain Res. 2006 Aug 11;1105(1):130-42
references.pmid: 16650836
references.citation: Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8301-6
references.pmid: 10393989
references.citation: J Neurosci. 2010 Sep 22;30(38):12759-69
references.pmid: 20861380
references.citation: Neuroreport. 2001 Jan 22;12(1):157-61
references.pmid: 11201078
references.citation: Neuropsychology. 2003 Apr;17(2):272-82
references.pmid: 12803433
references.citation: Neuroimage. 2001 Sep;14(3):709-22
references.pmid: 11506543
references.citation: Neuroimage. 2005 Aug 15;27(2):323-40
references.pmid: 16019232
references.citation: Neuroreport. 2004 Jan 19;15(1):129-33
references.pmid: 15106844
references.citation: Neuroimage. 2002 Dec;17(4):1820-9
references.pmid: 12498755
references.citation: Brain. 1995 Feb;118 ( Pt 1):279-306
references.pmid: 7895011
references.citation: Clin Neurophysiol. 2001 Dec;112(12):2224-32
references.pmid: 11738192
references.citation: Behav Brain Res. 2007 Jul 19;181(1):12-22
references.pmid: 17467816
references.citation: Biol Psychiatry. 2000 Aug 1;48(3):210-21
references.pmid: 10924664
references.citation: Neuroimage. 2005 Apr 15;25(3):899-915
references.pmid: 15808990
references.citation: Neuroimage. 2004 May;22(1):252-7
references.pmid: 15110015