title: [Current possibilities of correcting subchondral bone resorption as a major pathogenetic factor for progressive osteoarthrosis].
abstract: The paper considers the current pathogenesis, by choosing the actual targets of pharmacotherapy with available drugs. It reflects the cytokine mechanisms responsible for lesion of the synovial membranes, cartilage, and subchondral bone. Particular emphasis is laid on the role of chondroitin sulfate, glucosamine, vitamin D3 as drugs that affect the key components of pathogenesis, including the volume of resorptive cavities in the subchondral bone.
authors.forename: A V
authors.initials: AV
authors.lastname: Naumov
mesh_terms: D015519:Bone Density / Q000187:drug effects / Q000502:physiology*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D001862:Bone Resorption / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D002762:Cholecalciferol / Q000627:therapeutic use*; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D016207:Cytokines / Q000378:metabolism*; D005944:Glucosamine / Q000627:therapeutic use*; D006801:Humans; D010003:Osteoarthritis / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D016207:Cytokines; D002762:Cholecalciferol; D002809:Chondroitin Sulfates; D005944:Glucosamine