title: Successful treatment of acute kidney injury in patients with idiopathic nephrotic syndrome using human atrial natriuretic Peptide.
abstract: The acute onset of idiopathic nephrotic syndrome (NS) is often accompanied by acute kidney injury, which can lead to congestive heart failure and lung edema. In this report, we present two cases of NS-induced acute kidney injury successfully treated with a low dose of carperitide, a human atrial natriuretic peptide. In combination with standard diuretic therapy and immunotherapy, carperitide retained the renal function and spared the need for renal replacement therapy, including hemodialysis. Although further investigation in clinical trials is required to validate these findings, carperitide may be useful for maintaining the renal function in cases of NS-induced acute kidney injury.
authors.affiliation: Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Ueda
authors.forename: Junichi
authors.initials: J
authors.lastname: Hirahashi
authors.forename: George
authors.initials: G
authors.lastname: Seki
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Natsuki
authors.initials: N
authors.lastname: Kushida
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takeshima
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nishikawa
authors.forename: Toshiro
authors.initials: T
authors.lastname: Fujita
authors.forename: Masaomi
authors.initials: M
authors.lastname: Nangaku
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000209:etiology*; D000369:Aged, 80 and over; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications*
chemical_list: C472955:NPPA protein, human; D009320:Atrial Natriuretic Factor