title: Epidemiology of invasive mold infections in lung transplant recipients.
abstract: Invasive mold infections (IMIs) are a major source of morbidity and mortality among lung transplant recipients (LTRs), yet information regarding the epidemiology of IMI in this population is limited. From 2001 to 2006, multicenter prospective surveillance for IMIs among LTR was conducted by the Transplant-Associated Infection Surveillance Network. The epidemiology of IMI among all LTRs in the cohort is reported. Twelve percent (143/1173) of LTRs under surveillance at 15 US centers developed IMI infections. The 12-month cumulative incidence of IMIs was 5.5%; 3-month all-cause mortality was 21.7%. Aspergillus caused the majority (72.7%)of IMIs; non-Aspergillus infections (39, 27.3%) included Scedosporium (5, 3.5%), mucormycosis (3, 2.1%) and "unspecified" or "other" mold infections (31, 21.7%). Late-onset IMI was common: 52% occurred within 1 year posttransplant (median 11 months, range 0-162 months). IMIs are common late-onset complications with substantial mortality in LTRs. LTRs should be monitored for late-onset IMIs and prophylactic agents should be optimized based on likely pathogen.
authors.affiliation: Department of Pharmacy, Tampa General Hospital, Tampa, FL.
authors.forename: C T
authors.initials: CT
authors.lastname: Doligalski
authors.forename: K
authors.initials: K
authors.lastname: Benedict
authors.forename: A A
authors.initials: AA
authors.lastname: Cleveland
authors.forename: B
authors.initials: B
authors.lastname: Park
authors.forename: G
authors.initials: G
authors.lastname: Derado
authors.forename: P G
authors.initials: PG
authors.lastname: Pappas
authors.forename: J W
authors.initials: JW
authors.lastname: Baddley
authors.forename: D W
authors.initials: DW
authors.lastname: Zaas
authors.forename: M T
authors.initials: MT
authors.lastname: Harris
authors.forename: B D
authors.initials: BD
authors.lastname: Alexander
mesh_terms: D015331:Cohort Studies; D006801:Humans; D008171:Lung Diseases / Q000453:epidemiology* / Q000382:microbiology; D016040:Lung Transplantation; D009181:Mycoses / Q000453:epidemiology* / Q000382:microbiology
keywords: Epidemiology; infection; lung transplant; mold
references.citation: Transpl Infect Dis. 2006 Dec;8(4):213-8
references.pmid: 17116134
references.citation: Am J Respir Crit Care Med. 2012 Jul 1;186(1):56-64
references.pmid: 22517788
references.citation: Am J Transplant. 2011 Feb;11(2):361-6
references.pmid: 21272239
references.citation: Clin Infect Dis. 2010 Jun 15;50(12):1559-67
references.pmid: 20450350
references.citation: Am J Transplant. 2004 Nov;4 Suppl 10:110-34
references.pmid: 15504225
references.citation: Transpl Infect Dis. 2010 Jun;12(3):220-9
references.pmid: 20113459
references.citation: Curr Infect Dis Rep. 2009 Nov;11(6):427-34
references.pmid: 19857381
references.citation: Eur J Clin Microbiol Infect Dis. 2007 Dec;26(12):879-86
references.pmid: 17874329
references.citation: Am J Transplant. 2009 Dec;9 Suppl 4:S252-7
references.pmid: 20070686
references.citation: Clin Transplant. 2010 May-Jun;24(3):341-8
references.pmid: 19712081
references.citation: Transpl Infect Dis. 2001 Sep;3(3):161-7
references.pmid: 11493398
references.citation: Clin Infect Dis. 2010 Apr 15;50(8):1101-11
references.pmid: 20218876
references.citation: Clin Microbiol Infect. 2005 May;11(5):359-65
references.pmid: 15819861
references.citation: Clin Infect Dis. 2005 Jul 1;41(1):52-9
references.pmid: 15937763
references.citation: Am J Transplant. 2009 Dec;9 Suppl 4:S180-91
references.pmid: 20070679
references.citation: Clin Infect Dis. 2008 Jun 15;46(12):1813-21
references.pmid: 18462102
references.citation: Transplantation. 2000 Jul 15;70(1):112-6
references.pmid: 10919584
references.citation: Transplant Proc. 2007 Jul-Aug;39(6):2005-7
references.pmid: 17692677