title: Polymorphism of GST and FTO Genes in Risk Prediction of Cataract among a North Indian Population.
abstract: BACKGROUND
  The present study was carried out to investigate the association of GST and FTO gene polymorphisms with cataract cases and controls.
  
  
  METHODS
  The study included 131 cases and 126 controls. GST and FTO gene polymorphisms were evaluated by PCR-RFLP.
  
  
  RESULTS
  The frequency of the GSTM1-positive and GSTT1-positive in cataract cases were 62.13% and 86.40% while in the controls it was 46.39% and 95.87% with odds ratios of 1.9 (95% CI, 1.08-3.32; p value 0.025) and 0.27 (95% CI, 0.09-0.86; p value, 0.019) respectively. There was a statistically significant association between the GSTM1 null genotype and the risk of cataract development with an odds ratio of 0.43 (95% CI, 0.24-0.76; p value, 0.003). Significant differences were obtained in the frequencies of FTO AA and TT genotype (p = 0.023 and 0.023) between cases and controls.
  
  
  CONCLUSIONS
  The present study suggested that GSTM1, GSTT1 and FTO gene polymorphisms are associated with increased risk for cataract in North Indian populations. Due to the limited sample size, the finding on GST and FTO gene polymorphisms need further investigation.
authors.affiliation: a Departments of Biochemistry and.
authors.forename: Anu
authors.initials: A
authors.lastname: Chandra
authors.affiliation: a Departments of Biochemistry and.
authors.forename: Syed Tasleem
authors.initials: ST
authors.lastname: Raza
authors.affiliation: a Departments of Biochemistry and.
authors.forename: Shania
authors.initials: S
authors.lastname: Abbas
authors.affiliation: b Opthalmology, Era's Lucknow Medical College and Hospital , Lucknow , India.
authors.forename: Luxmi
authors.initials: L
authors.lastname: Singh
authors.affiliation: a Departments of Biochemistry and.
authors.forename: Saliha
authors.initials: S
authors.lastname: Rizvi
authors.affiliation: a Departments of Biochemistry and.
authors.forename: Faisal
authors.initials: F
authors.lastname: Ahmed
authors.affiliation: a Departments of Biochemistry and.
authors.forename: Ale
authors.initials: A
authors.lastname: Eba
authors.affiliation: a Departments of Biochemistry and.
authors.forename: Farzana
authors.initials: F
authors.lastname: Mahdi
mesh_terms: D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D044466:Asian People / Q000235:genetics*; D002386:Cataract / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012307:Risk Factors
chemical_list: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D005982:Glutathione Transferase; D011506:Proteins; C526492:FTO protein, human; C413545:glutathione S-transferase T1
keywords: Cataract; FTO; GST; genetic polymorphism