title: Ovarian granulosa cell tumor: clinical features, treatment, outcome, and prognostic factors.
abstract: BACKGROUND
  Granulosa cell tumors are rare neoplasms characterized by long natural history and favorable prognosis.
  
  
  OBJECTIVE
  The objective of this study was to determine the clinical presentation, treatment, outcome, and prognostic factors for patients of granulosa cell tumors.
  
  
  METHODS
  A retrospective analysis of 26 patients of granulosa cell tumor of ovary from 2002 to 2011 was carried out. The records of all patients were analyzed to determine clinical presentation, treatment, survival, and prognostic factors.
  
  
  RESULTS
  The median age of the patients was 50 years (range, 17-71 years). Abdominal pain was the most common presenting symptom. The median follow-up was 71.4 months (range, 21.6-149.9 months). The estimated 5 and 10 year overall survival (OS) was 84.6 and 72.5%, respectively. Event-free survival (EFS) was 76.5 and 52.9% at 5 and 10 years, respectively. Advanced stage was significant independent poor prognostic indicator for both OS and EFS.
  
  
  CONCLUSIONS
  Majority of the patients with granulosa cell tumors of the ovary present in early stage. Surgery is the primary treatment modality for granulosa cell tumors. Advanced stage and presence of residual disease were associated with inferior survival, but only prospective studies can ascertain their definite role.
authors.affiliation: Department of Radiotherapy and Oncology, Government Medical College and Hospital, Chandigarh, India.
authors.forename: Divya
authors.initials: D
authors.lastname: Khosla
authors.affiliation: Department of Radiotherapy and Oncology, Government Medical College and Hospital, Chandigarh, India.
authors.forename: Kislay
authors.initials: K
authors.lastname: Dimri
authors.affiliation: Department of Radiotherapy and Oncology, Government Medical College and Hospital, Chandigarh, India.
authors.forename: Awadhesh K
authors.initials: AK
authors.lastname: Pandey
authors.affiliation: Department of Radiotherapy and Oncology, Government Medical College and Hospital, Chandigarh, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Mahajan
authors.affiliation: Department of Radiotherapy and Oncology, Government Medical College and Hospital, Chandigarh, India.
authors.forename: Romeeta
authors.initials: R
authors.lastname: Trehan
keywords: Granulosa cell tumor; Ovary; Prognosis; Survival; Treatment
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