title: Evaluation of cytokines as Th1/Th2 markers in pathogenesis of children with Crimean-Congo hemorrhagic fever.
abstract: Cytokine networks play a key role in the pathogenesis of the disease in Crimean-Congo Hemorrhagic Fever (CCHF) patients. Therefore, our aim was to study the effects of cytokine levels on the pathogenesis and severity of the disease in children with CCHF. Fifty-two patients diagnosed with CCHF and 34 healthy controls (HC) were included in the study. The patients with CCHF were divided into two groups (severe and non-severe). The levels of the Interleukin-10 (IL-10), IL-12, IL-6, Endothelin-1 (ET-1) and tumor necrosis factor-α (TNF-α) were measured in all groups. IL-12 levels did not show any difference between the CCHF and HC groups and among the severe, non-severe and HC groups. IL-10 and ET-1 levels were significantly higher in the severe group when compared to the non-severe group and the HC group. Moreover, IL-10 and ET-1 levels were significantly higher in the non-severe group when compared to the HC group. In terms of IL-6 and TNF-α levels, there was no difference between the severe and non-severe groups while the said levels were significantly higher in the severe group when compared to the HC group. The results of the present study showing significantly higher IL-10 and ET-1 levels in the severe group suggest that Th2-mediated humoral immunity is more effective in the pathogenesis and severity of CCHF in children.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Cumhuriyet University Sivas, Turkey.
authors.forename: Enver
authors.initials: E
authors.lastname: Sancakdar
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cumhuriyet University Sivas, Turkey.
authors.forename: Ahmet Sami
authors.initials: AS
authors.lastname: Güven
authors.affiliation: Department of Microbiology, Faculty of Medicine, Cumhuriyet University Sivas, Turkey.
authors.forename: Elif Bilge
authors.initials: EB
authors.lastname: Uysal
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cumhuriyet University Sivas, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Kaya
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Cumhuriyet University Sivas, Turkey.
authors.forename: Köksal
authors.initials: K
authors.lastname: Deveci
authors.affiliation: Department of Cardiology, Faculty of Medicine, Cumhuriyet University Sivas, Turkey.
authors.forename: Hekim
authors.initials: H
authors.lastname: Karapınar
authors.affiliation: Department of Pediatrics, Sivas State Hospital Sivas, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Akkar
keywords: Crimean-Congo hemorrhagic fever; ET-1; IL-10; IL-12; Th2
references.citation: Antiviral Res. 2004 Dec;64(3):145-60
references.pmid: 15550268
references.citation: J Virol. 2007 Jun;81(11):5518-26
references.pmid: 17360740
references.citation: J Virol. 2003 Feb;77(3):1727-37
references.pmid: 12525606
references.citation: Clin Sci (Lond). 2012 Feb;122(4):143-59
references.pmid: 22029668
references.citation: Curr Opin Virol. 2012 Apr;2(2):215-20
references.pmid: 22482717
references.citation: Clin Vaccine Immunol. 2010 Jul;17(7):1086-93
references.pmid: 20484568
references.citation: APMIS. 2014 Jul;122(7):643-7
references.pmid: 24320760
references.citation: J Clin Virol. 2006 Aug;36(4):272-6
references.pmid: 16765637
references.citation: Am J Trop Med Hyg. 1987 Jan;36(1):120-32
references.pmid: 3101525
references.citation: J Infect Dis. 2006 Apr 1;193(7):941-4
references.pmid: 16518755
references.citation: J Med Virol. 1999 Nov;59(3):329-34
references.pmid: 10502265
references.citation: Cytokine Growth Factor Rev. 2003 Oct;14(5):361-8
references.pmid: 12948519
references.citation: Clin Microbiol Infect. 2010 Jul;16(7):843-7
references.pmid: 19845692
references.citation: Eur J Clin Microbiol Infect Dis. 2002 Aug;21(8):603-6
references.pmid: 12226691
references.citation: Am J Respir Cell Mol Biol. 2003 May;28(5):574-81
references.pmid: 12707013
references.citation: J Infect Dis. 2004 Nov 15;190(10):1821-7
references.pmid: 15499539
references.citation: J Virol. 2010 Nov;84(21):11089-100
references.pmid: 20739514
references.citation: Int J Infect Dis. 2008 Jul;12(4):374-9
references.pmid: 18063402
references.citation: Rev Infect Dis. 1989 May-Jun;11 Suppl 4:S794-800
references.pmid: 2749111
references.citation: Can J Physiol Pharmacol. 2003 Jun;81(6):635-43
references.pmid: 12839274
references.citation: Lancet Infect Dis. 2006 Apr;6(4):203-14
references.pmid: 16554245
references.citation: Cytokine Growth Factor Rev. 2010 Oct;21(5):331-44
references.pmid: 21115385
references.citation: J Hypertens Suppl. 1988 Dec;6(4):S188-91
references.pmid: 2853725
references.citation: J Clin Virol. 2010 Apr;47(4):361-5
references.pmid: 20149724
references.citation: J Med Virol. 2013 Nov;85(11):1955-9
references.pmid: 23893846