title: Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies.
abstract: Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warburg's discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients.
authors.affiliation: 1 Department of Molecular and Cellular Oncology, 2 Department of General Internal Medicine, Ambulatory Treatment and Emergency Care, 3 Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas, TX77030, USA.
authors.forename: Liem Minh
authors.initials: LM
authors.lastname: Phan
authors.affiliation: 1 Department of Molecular and Cellular Oncology, 2 Department of General Internal Medicine, Ambulatory Treatment and Emergency Care, 3 Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas, TX77030, USA.
authors.forename: Sai-Ching Jim
authors.initials: SC
authors.lastname: Yeung
authors.affiliation: 1 Department of Molecular and Cellular Oncology, 2 Department of General Internal Medicine, Ambulatory Treatment and Emergency Care, 3 Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas, TX77030, USA.
authors.forename: Mong-Hong
authors.initials: MH
authors.lastname: Lee
keywords: Cell cycle; energy metabolism; glutaminolysis; glycolysis; mitochondria biogenesis
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