title: Embryo toxic effects of depleted uranium on the morphology of the mouse fetus.
abstract: Although the biokinetics, metabolism, and chemical toxicity of uranium are well known, until recently little attention was paid to the potential toxic effects of uranium on reproduction and development in mammals. In recent years, it has been shown that uranium is a developmental toxicant when given orally or subcutaneously (SC) to mice. Decreased fertility, embryo/fetal toxicity including teratogenicity, and reduced growth of the offspring have been observed following uranium exposure at different gestation periods. For investigating the effects of DU on pregnant animals, three groups (control, sham and test) of NMRI mice were chosen. In test group 4 mg/Kg of DU were administered intraperitonealy at 11 day of gestation, in sham group only normal saline injected to interior peritoneum as indicated in the test group and in Control group which was considered as the comparison base line of our research, no injection was made. Caesarean sections were performed at 15 day of the gestation; and their placentas were examined externally. Base on our results DU caused significant external anomalies, and caused a significant decrease (p < 0.05) in the weight and diameter of placentas, the number of the embryos, their body weight and crown-rump length of fetuses.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Department of Pharmacology and Toxicology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Nina
authors.initials: N
authors.lastname: Mirderikvand
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Baharak
authors.initials: B
authors.lastname: Mohammadzadeh Asl
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Naserzadeh
authors.affiliation: Department of Pharmacology and Toxicology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Shaki
authors.affiliation: Department of Pharmacology and Toxicology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shokrzadeh
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Jalal
authors.initials: J
authors.lastname: Pourahmad
keywords: Depleted uranium; Embryotoxicity; Morphology; Mouse fetus
references.citation: Biochim Biophys Acta. 2012 Dec;1820(12):1940-50
references.pmid: 22940002
references.citation: Toxicology. 1989 Apr;55(1-2):143-52
references.pmid: 2711400
references.citation: Environ Toxicol. 2006 Aug;21(4):349-54
references.pmid: 16841314
references.citation: Health Phys. 1983;44 Suppl 1:377-84
references.pmid: 6862914
references.citation: Int J Health Serv. 2006;36(3):503-20
references.pmid: 16981628
references.citation: Teratog Carcinog Mutagen. 1987;7(3):287-95
references.pmid: 2888207
references.citation: Birth Defects Res B Dev Reprod Toxicol. 2007 Feb;80(1):2-11
references.pmid: 17187389
references.citation: Health Phys. 1983 Jul;45(1):89-99
references.pmid: 6874353
references.citation: Metallomics. 2013 Jun;5(6):736-44
references.pmid: 23629690