title: Silicon calcium phosphate ceramic as novel biomaterial to simulate the bone regenerative properties of autologous bone.
abstract: This study was conducted to develop novel ceramic bone substitute that resembles the autologous bone behavior when used as graft material. Solid-state reaction at 1100°C was performed to synthesize β-tricalcium phosphate (β-TCP) and biphasic calcium phosphate (BCP). The ceramics were further analyzed to characterize phase composition, microstructural properties, cytocompatability and then challenged to regenerate critical bone defects in the parietal bone of rabbits. X-ray diffraction analysis confirmed the production of β-TCP and indicated the synthesis of novel BCP composed of β-TCP and silicocarnotite (calcium phosphate silicate mineral). The cytocompatibility test with human osteoblast cell line revealed enhanced cell proliferation on the BCP ceramic. The novel BCP induced the filling of about 73% of the bone defect with a newly formed bone tissue and an almost complete degradation after 12 weeks of healing. This novel ceramic resembles the autologous bone properties of complete degradation and efficient enhancement of bone formation, making it promising as bone graft material.
authors.affiliation: Department of Physical-Chemistry II, Faculty of Pharmacy, Complutense University of Madrid, 28040, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Manchón
authors.forename: M
authors.initials: M
authors.lastname: Alkhraisat
authors.forename: C
authors.initials: C
authors.lastname: Rueda-Rodriguez
authors.forename: J
authors.initials: J
authors.lastname: Torres
authors.forename: J C
authors.initials: JC
authors.lastname: Prados-Frutos
authors.forename: A
authors.initials: A
authors.lastname: Ewald
authors.forename: U
authors.initials: U
authors.lastname: Gbureck
authors.forename: J
authors.initials: J
authors.lastname: Cabrejos-Azama
authors.forename: A
authors.initials: A
authors.lastname: Rodriguez-González
authors.forename: E
authors.initials: E
authors.lastname: López-Cabarcos
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D011817:Rabbits; D017655:Silicon Compounds / Q000737:chemistry / Q000494:pharmacology
chemical_list: D002130:Calcium Phosphates; D017655:Silicon Compounds; C485817:beta-tricalcium phosphate
keywords: biphasic calcium phosphate; bone graft; bone substitution; silicon doped ceramic; tricalcium phosphate