title: The others: our biased perspective of eukaryotic genomes.
abstract: Understanding the origin and evolution of the eukaryotic cell and the full diversity of eukaryotes is relevant to many biological disciplines. However, our current understanding of eukaryotic genomes is extremely biased, leading to a skewed view of eukaryotic biology. We argue that a phylogeny-driven initiative to cover the full eukaryotic diversity is needed to overcome this bias. We encourage the community: (i) to sequence a representative of the neglected groups available at public culture collections, (ii) to increase our culturing efforts, and (iii) to embrace single cell genomics to access organisms refractory to propagation in culture. We hope that the community will welcome this proposal, explore the approaches suggested, and join efforts to sequence the full diversity of eukaryotes.
authors.affiliation: Institut de Biologia Evolutiva, CSIC-Universitat Pompeu Fabra, Barcelona, Catalonia, Spain; University of British Columbia, Vancouver, BC, Canada. Electronic address: javier.delcampo@botany.ubc.ca.
authors.forename: Javier
authors.initials: J
authors.lastname: del Campo
authors.affiliation: Bigelow Laboratory for Ocean Sciences, East Boothbay, ME, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Sieracki
authors.affiliation: American Type Culture Collection, Manassas, VA, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Molestina
authors.affiliation: University of British Columbia, Vancouver, BC, Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Keeling
authors.affiliation: Institut de Ciències del Mar, CSIC, Barcelona, Catalonia, Spain.
authors.forename: Ramon
authors.initials: R
authors.lastname: Massana
authors.affiliation: Institut de Biologia Evolutiva, CSIC-Universitat Pompeu Fabra, Barcelona, Catalonia, Spain; Departament de Genètica, Universitat de Barcelona, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Electronic address: inaki.ruiz@multicellgenome.org.
authors.forename: Iñaki
authors.initials: I
authors.lastname: Ruiz-Trillo
mesh_terms: D005075:Biological Evolution; D018929:Cell Culture Techniques; D056890:Eukaryota / Q000235:genetics*; D023281:Genomics; D010802:Phylogeny
keywords: culture collections; culturing bias; ecology; eukaryotic genomics; eukaryotic tree of life; phylogeny; single cell genomics
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