title: Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial.
abstract: BACKGROUND
  Patients with stable COPD show improvements in exercise capacity and muscular function after the application of whole body vibration. We aimed to evaluate whether this modality added to conventional physiotherapy in exacerbated hospitalised COPD patients would be safe and would improve exercise capacity and quality of life.
  
  
  METHODS
  49 hospitalised exacerbated COPD patients were randomized (1:1) to undergo physiotherapy alone or physiotherapy with the addition of whole body vibration. The primary endpoint was the between-group difference of the 6-minute walking test (day of discharge - day of admission). Secondary assessments included chair rising test, quality of life, and serum marker analysis.
  
  
  RESULTS
  Whole body vibration did not cause procedure-related adverse events. Compared to physiotherapy alone, it led to significantly stronger improvements in 6-minute walking test (95.55 ± 76.29 m vs. 6.13 ± 81.65 m; p = 0.007) and St. Georges Respiratory Questionnaire (-6.43 ± 14.25 vs. 5.59 ± 19.15, p = 0.049). Whole body vibration increased the expression of the transcription factor peroxisome proliferator receptor gamma coactivator-1-α and serum levels of irisin, while it decreased serum interleukin-8.
  
  
  CONCLUSIONS
  Whole body vibration during hospitalised exacerbations did not cause procedure-related adverse events and induced clinically significant benefits regarding exercise capacity and health-related quality of life that were associated with increased serum levels of irisin, a marker of muscle activity.
  
  
  BACKGROUND
  German Clinical Trials Register DRKS00005979. Registered 17 March 2014.
authors.forename: Timm
authors.initials: T
authors.lastname: Greulich
authors.forename: Christoph
authors.initials: C
authors.lastname: Nell
authors.forename: Janine
authors.initials: J
authors.lastname: Koepke
authors.forename: Juliane
authors.initials: J
authors.lastname: Fechtel
authors.forename: Maja
authors.initials: M
authors.lastname: Franke
authors.forename: Bernd
authors.initials: B
authors.lastname: Schmeck
authors.forename: Daniel
authors.initials: D
authors.lastname: Haid
authors.forename: Sandra
authors.initials: S
authors.lastname: Apelt
authors.forename: Silke
authors.initials: S
authors.lastname: Filipovic
authors.forename: Klaus
authors.initials: K
authors.lastname: Kenn
authors.forename: Sabina
authors.initials: S
authors.lastname: Janciauskiene
authors.forename: Claus
authors.initials: C
authors.lastname: Vogelmeier
authors.affiliation: Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University, Member of the German Center for Lung Research (DZL), Marburg 35043, Germany. koczulla@med.uni-marburg.de.
authors.forename: Andreas Rembert
authors.initials: AR
authors.lastname: Koczulla
mesh_terms: D000368:Aged; D018450:Disease Progression; D017079:Exercise Tolerance; D005260:Female; D005353:Fibronectins / Q000097:blood; D006760:Hospitalization; D006801:Humans; D008297:Male; D026741:Physical Therapy Modalities; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D011788:Quality of Life; D016037:Single-Blind Method; D014732:Vibration / Q000627:therapeutic use*
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins
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