title: Novel thiazole derivatives: a patent review (2008 - 2012. Part 2).
abstract: BACKGROUND
  Thiazole is a well-known five-membered heterocyclic compound. Various methods have been worked out for its synthesis. In the last few decades, a lot of work has been done on the thiazole ring to find new drugs with antioxidant, analgesic, anti-inflammatory, antimicrobial, antifungal, antiviral, diuretic, anticonvulsant, neuroprotective and antitumor or cytotoxic properties and fewer side effects. This review presents the up-to-date development of different thiazole derivatives.
  
  
  METHODS
  The present review gives an account of the recent therapeutic patent literature (2008 - 2012) describing the applications of thiazole and its derivatives on selected activities. In this review, many relevant biological properties and therapeutic applications of thiazole derivatives reported in international patents from all companies have been discussed; an overview of the chemical matter has also been given. Because of the huge amount of patents registered in this period relative to thiazole derivatives, attention has been focused on thiazole derivatives having pharmacological activity toward receptors.
  
  
  CONCLUSIONS
  Based on the large variety of possible therapeutic applications proposed in patents for thiazole derivatives having pharmacological activity toward receptors, it is possible to point out the unpredictability of pharmacological activity consequent to structural modification, more or less simple, of a prototype drug molecule. In any case, the thiazole scaffold continues to have great potential in chemical pharmaceutical research.
authors.affiliation: Università degli Studi di Bologna, Dipartimento di Farmacia e Biotecnologie , Via Belmeloro 6, 40126 Bologna , Italy alberto.leoni@unibo.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Leoni
authors.forename: Alessandra
authors.initials: A
authors.lastname: Locatelli
authors.forename: Rita
authors.initials: R
authors.lastname: Morigi
authors.forename: Mirella
authors.initials: M
authors.lastname: Rambaldi
mesh_terms: D000818:Animals; D015195:Drug Design; D006801:Humans; D010330:Patents as Topic; D011955:Receptors, Drug / Q000187:drug effects; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D011955:Receptors, Drug; D013844:Thiazoles
keywords: agonist; antagonist; modulator; receptor; thiazole