title: Acupuncture Enhances Effective Connectivity between Cerebellum and Primary Sensorimotor Cortex in Patients with Stable Recovery Stroke.
abstract: Recent neuroimaging studies have demonstrated that stimulation of acupuncture at motor-implicated acupoints modulates activities of brain areas relevant to the processing of motor functions. This study aims to investigate acupuncture-induced changes in effective connectivity among motor areas in hemiparetic stroke patients by using the multivariate Granger causal analysis. A total of 9 stable recovery stroke patients and 8 healthy controls were recruited and underwent three runs of fMRI scan: passive finger movements and resting state before and after manual acupuncture stimuli. Stroke patients showed significantly attenuated effective connectivity between cortical and subcortical areas during passive motor task, which indicates inefficient information transmissions between cortical and subcortical motor-related regions. Acupuncture at motor-implicated acupoints showed specific modulations of motor-related network in stroke patients relative to healthy control subjects. This specific modulation enhanced bidirectionally effective connectivity between the cerebellum and primary sensorimotor cortex in stroke patients, which may compensate for the attenuated effective connectivity between cortical and subcortical areas during passive motor task and, consequently, contribute to improvement of movement coordination and motor learning in subacute stroke patients. Our results suggested that further efficacy studies of acupuncture in motor recovery can focus on the improvement of movement coordination and motor learning during motor rehabilitation.
authors.affiliation: Department of Neurology, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China ; Dongzhimen Hospital Eastern Affiliated to Beijing University of Chinese Medicine, Beijing 101100, China.
authors.forename: Zijing
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Department of Neurology, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China.
authors.forename: Fangyuan
authors.initials: F
authors.lastname: Cui
authors.affiliation: Department of Neurology, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China.
authors.forename: Yihuai
authors.identifier: 0000-0002-4003-8244
authors.initials: Y
authors.lastname: Zou
authors.affiliation: The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
authors.forename: Lijun
authors.identifier: 0000-0001-8790-5424
authors.initials: L
authors.lastname: Bai
references.citation: Neuroimage. 2010 Mar;50(1):233-42
references.pmid: 20005962
references.citation: Neuroimage. 2004 May;22(1):394-400
references.pmid: 15110032
references.citation: Brain. 2011 May;134(Pt 5):1264-76
references.pmid: 21414995
references.citation: J Rehabil Med. 2007 Apr;39(3):205-11
references.pmid: 17468788
references.citation: Hum Brain Mapp. 2009 Apr;30(4):1361-73
references.pmid: 18537116
references.citation: Neuroimage. 2008 Sep 1;42(3):1178-84
references.pmid: 18598773
references.citation: Am J Chin Med. 2005;33(4):573-8
references.pmid: 16173531
references.citation: Evid Based Complement Alternat Med. 2013;2013:812568
references.pmid: 23737848
references.citation: Brain. 2003 Nov;126(Pt 11):2476-96
references.pmid: 12937084
references.citation: Brain Res. 2009 Jul 7;1279:37-49
references.pmid: 19427842
references.citation: Neuroimage. 2004 Nov;23(3):827-39
references.pmid: 15528083
references.citation: J Psychiatr Res. 1975 Nov;12(3):189-98
references.pmid: 1202204
references.citation: Exp Neurol. 2006 Oct;201(2):375-87
references.pmid: 16828743
references.citation: Neurorehabil Neural Repair. 2007 Sep-Oct;21(5):412-28
references.pmid: 17369516
references.citation: J Altern Complement Med. 2007 Jun;13(5):527-32
references.pmid: 17604556
references.citation: Curr Opin Neurol. 2012 Dec;25(6):670-5
references.pmid: 23108249
references.citation: Neurosci Lett. 1997 May 23;227(3):161-4
references.pmid: 9185675
references.citation: Brain Res Brain Res Rev. 2000 Mar;31(2-3):236-50
references.pmid: 10719151
references.citation: Brain. 2010 Apr;133(Pt 4):1224-38
references.pmid: 20354002
references.citation: Lasers Med Sci. 2005 Sep;20(2):68-73
references.pmid: 15990948
references.citation: Ann Neurol. 2008 Feb;63(2):236-46
references.pmid: 17896791
references.citation: Top Stroke Rehabil. 2009 Jul-Aug;16(4):270-81
references.pmid: 19740732
references.citation: Stroke. 2011 May;42(5):1357-62
references.pmid: 21441147
references.citation: Brain Res. 2009 Jul 14;1280:107-16
references.pmid: 19445910
references.citation: Evid Based Complement Alternat Med. 2011;2011:
references.pmid: 20953400
references.citation: Zhongguo Zhen Jiu. 2006 May;26(5):357-61
references.pmid: 16739854
references.citation: J Rehabil Med. 2009 Apr;41(5):312-6
references.pmid: 19363561
references.citation: Neurosci Lett. 2002 Jul 12;327(1):53-6
references.pmid: 12098499
references.citation: Neuroimage. 2011 Feb 14;54(4):2683-94
references.pmid: 21073960
references.citation: Science. 1994 Sep 23;265(5180):1826-31
references.pmid: 8091209
references.citation: Neuroimage. 2005 Sep;27(3):479-96
references.pmid: 16046146
references.citation: Neuropsychologia. 1971 Mar;9(1):97-113
references.pmid: 5146491
references.citation: PLoS One. 2013 May 28;8(5):e64154
references.pmid: 23724030
references.citation: J Magn Reson Imaging. 2011 Jul;34(1):31-42
references.pmid: 21698705
references.citation: IEEE Trans Biomed Eng. 2004 Sep;51(9):1501-10
references.pmid: 15376498
references.citation: Anat Rec (Hoboken). 2009 Dec;292(12):2023-31
references.pmid: 19943355
references.citation: Mol Pain. 2010 Nov 02;6:73
references.pmid: 21044291
references.citation: Neurosci Lett. 2009 Oct 25;462(3):183-7
references.pmid: 19595739
references.citation: Brain Struct Funct. 2010 Jun;214(5-6):655-67
references.pmid: 20512370
references.citation: Neuroimage. 2002 Feb;15(2):373-85
references.pmid: 11798272
references.citation: Neuroimage. 2007 Sep 1;37(3):927-36
references.pmid: 17629500
references.citation: PLoS One. 2012;7(11):e49154
references.pmid: 23152865
references.citation: Brain. 2002 Dec;125(Pt 12):2731-42
references.pmid: 12429600
references.citation: Neurology. 2000 Jan 11;54(1):135-42
references.pmid: 10636139
references.citation: Hum Brain Mapp. 2009 Nov;30(11):3445-60
references.pmid: 19350547
references.citation: PLoS Comput Biol. 2012 Feb;8(2):e1002374
references.pmid: 22319436
references.citation: Pain. 2008 Jun;136(3):407-418
references.pmid: 18337009
references.citation: Ann Intern Med. 2002 Mar 5;136(5):374-83
references.pmid: 11874310
references.citation: Ann Neurol. 2011 Feb;69(2):375-88
references.pmid: 21387380
references.citation: Curr Opin Neurol. 2006 Feb;19(1):84-90
references.pmid: 16415682