title: Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer.
abstract: The combination of CT imaging and photoacoustic (PA) imaging represents not only high resolution and ease of forming 3D visual image for locating tissues of interest, but also good soft tissue contrast and excellent high sensitivity, which is very beneficial to the precise guidance for photothermal therapy (PTT). The near infrared (NIR) absorbing Au nanostructures take advantages to operate as a CT contrast agent due to high absorption coefficient of X-ray and outstanding biocompatibility, but show obvious deficiency for PA imaging and PTT because of low photostability. Attacking this problem head on, the Au nanoparticles (NPs) were coated with Prussian blue (PB) which is a typical FDA-approved drug in clinic for safe and effective treatment of radioactive exposure. The obtained core/shell NPs of Au@PB NPs of 17.8 ± 2.3 nm were found to be an excellent photoabsorbing agent for both PTT and PA imaging due to high photostability and high molar extinction coefficient in NIR region. Their gold core of 9.1 ± 0.64 nm ensured a remarkable contrast enhancement for CT imaging. Through a one-time treatment of NIR laser irradiation after intravenous injection of Au@PB NPs, 100 mm(3) sized tumors in nude mice could be completely ablated without recurrence. Such versatile nanoparticles integrating effective cancer diagnosis with noninvasive therapy might bring opportunities to future cancer therapy.
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Lijia
authors.initials: L
authors.lastname: Jing
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Zijian
authors.initials: Z
authors.lastname: Deng
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Feng
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Xiaoda
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Maomao
authors.initials: M
authors.lastname: Huang
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Changhui
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China. Electronic address: zhifei.dai@163.com.
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Dai
mesh_terms: D000818:Animals; D005295:Ferrocyanides / Q000737:chemistry / Q000627:therapeutic use*; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use*; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy; D061088:Photoacoustic Techniques; D010789:Phototherapy; D014057:Tomography, X-Ray Computed
chemical_list: D005295:Ferrocyanides; D006046:Gold; C000170:ferric ferrocyanide
keywords: Au nanoparticles; Photoacoustic imaging; Photothermal therapy; Prussian blue; X-ray computed tomography