title: Complexities of lysophospholipid signalling in glioblastoma.
abstract: Glioblastoma multiforme (GBM) is the most malignant brain tumour and continues to have a very poor median survival of 12-16 months despite current best therapies. These aggressive tumours always recur after treatment and are defined by their ability to diffusely infiltrate and invade normal brain parenchyma. Autotaxin is overexpressed in GBM, and is a potent chemotactic enzyme that produces lysophosphatidic acid. Lysophospholipid (LPL) signalling is known to increase invasion of solid tumours and is also dysregulated in GBM. The LPL pathway has been shown to interact with known cancer-related signalling pathways, including those for epidermal growth factor and yes-associated protein, which are also dysregulated in GBM. The interactions between these pathways provide insights into the complexities of cancer signalling and suggest potential novel targets for GBM.
authors.affiliation: University of Melbourne, Parkville, VIC, Australia; Department of Surgery, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia; Department of Neurosurgery, Royal Melbourne Hospital, Parkville, VIC, Australia; Melbourne Brain Centre at Royal Melbourne Hospital, Parkville, VIC, Australia.
authors.forename: Wayne
authors.initials: W
authors.lastname: Ng
authors.affiliation: University of Melbourne, Parkville, VIC, Australia; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.
authors.forename: Alice
authors.initials: A
authors.lastname: Pébay
authors.affiliation: University of Melbourne, Parkville, VIC, Australia; Department of Surgery, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia; Department of Neurosurgery, Royal Melbourne Hospital, Parkville, VIC, Australia; Melbourne Brain Centre at Royal Melbourne Hospital, Parkville, VIC, Australia.
authors.forename: Katharine
authors.initials: K
authors.lastname: Drummond
authors.affiliation: University of Melbourne, Parkville, VIC, Australia; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
authors.forename: Antony
authors.initials: A
authors.lastname: Burgess
authors.affiliation: University of Melbourne, Parkville, VIC, Australia; Department of Surgery, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia; Department of Neurosurgery, Royal Melbourne Hospital, Parkville, VIC, Australia.
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Kaye
authors.affiliation: University of Melbourne, Parkville, VIC, Australia; Department of Surgery, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia; Department of Neurosurgery, Royal Melbourne Hospital, Parkville, VIC, Australia. Electronic address: morokoff@unimelb.edu.au.
authors.forename: Andrew
authors.initials: A
authors.lastname: Morokoff
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology; D005909:Glioblastoma / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D008246:Lysophospholipids; C032881:lysophosphatidic acid
keywords: Autotaxin; Glioblastoma multiforme; Lysophosphatidic acid