title: Developments in preclinical cancer imaging: innovating the discovery of therapeutics.
abstract: Integrating biological imaging into early stages of the drug discovery process can provide invaluable readouts of drug activity within complex disease settings, such as cancer. Iterating this approach from initial lead compound identification in vitro to proof-of-principle in vivo analysis represents a key challenge in the drug discovery field. By embracing more complex and informative models in drug discovery, imaging can improve the fidelity and statistical robustness of preclinical cancer studies. In this Review, we highlight how combining advanced imaging with three-dimensional systems and intravital mouse models can provide more informative and disease-relevant platforms for cancer drug discovery.
authors.affiliation: Garvan Institute of Medical Research and The Kinghorn Cancer Centre Sydney, St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, New South Wales 2010, Sydney, Australia.
authors.forename: James R W
authors.initials: JR
authors.lastname: Conway
authors.affiliation: Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XR, UK.
authors.forename: Neil O
authors.initials: NO
authors.lastname: Carragher
authors.affiliation: Garvan Institute of Medical Research and The Kinghorn Cancer Centre Sydney, St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, New South Wales 2010, Sydney, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Timpson
mesh_terms: D000818:Animals; D016880:Anisotropy; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015374:Biosensing Techniques; D003094:Collagen / Q000737:chemistry; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D021621:Imaging, Three-Dimensional; D051379:Mice; D008853:Microscopy; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology; D013678:Technology, Pharmaceutical / Q000379:methods*; D023822:Tissue Engineering
chemical_list: D000970:Antineoplastic Agents; D003094:Collagen
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