title: Molecules involved in the crosstalk between immune- and peripheral nerve Schwann cells.
abstract: Schwann cells are the myelinating glial cells of the peripheral nervous system and establish myelin sheaths on large caliber axons in order to accelerate their electrical signal propagation. Apart from this well described function, these cells revealed to exhibit a high degree of differentiation plasticity as they were shown to re- and dedifferentiate upon injury and disease as well as to actively participate in regenerative- and inflammatory processes. This review focuses on the crosstalk between glial- and immune cells observed in many peripheral nerve pathologies and summarizes functional evidences of molecules, regulators and factors involved in this process. We summarize data on Schwann cell's role presenting antigens, on interactions with the complement system, on Schwann cell surface molecules/receptors and on secreted factors involved in immune cell interactions or para-/autocrine signaling events, thus strengthening the view for a broader (patho) physiological role of this cell lineage.
authors.affiliation: Department of Neurology, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, D-40225, Düsseldorf, Germany.
authors.forename: Nevena
authors.initials: N
authors.lastname: Tzekova
authors.forename: André
authors.initials: A
authors.lastname: Heinen
authors.forename: Patrick
authors.initials: P
authors.lastname: Küry
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D002450:Cell Communication; D002454:Cell Differentiation; D003165:Complement System Proteins / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D009413:Nerve Fibers, Myelinated / Q000276:immunology*; D017933:Peripheral Nervous System / Q000166:cytology / Q000276:immunology*; D012583:Schwann Cells / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D008565:Membrane Proteins; D003165:Complement System Proteins
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