title: Role of caveolin-1 in asthma and chronic inflammatory respiratory diseases.
abstract: Caveolin-1 (Cav-1) is the major protein present in invaginations of the plasma membrane of cells known as caveolae. Cav-1 is expressed in numerous resident and inflammatory cells implicated in the pathogenesis of asthma and chronic inflammatory respiratory diseases including chronic obstructive pulmonary disease. A remarkable repertoire of functions has been identified for Cav-1 and these extend to, and have relevance to, asthma and chronic inflammatory respiratory diseases. Important processes influenced by Cav-1 include inflammation, fibrosis, smooth muscle contractility, regulation of apoptosis and cell senescence as well as epithelial barrier function and homeostasis. A better understanding of Cav-1 may be useful in developing new therapies for chronic inflammatory respiratory diseases.
authors.affiliation: Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
authors.forename: Simon G
authors.initials: SG
authors.lastname: Royce
authors.forename: Claude Jourdan
authors.initials: CJ
authors.lastname: Le Saux
mesh_terms: D000818:Animals; D001249:Asthma / Q000378:metabolism / Q000503:physiopathology*; D051242:Caveolin 1; D016922:Cellular Senescence / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000378:metabolism; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D051242:Caveolin 1
keywords: airway hyperresponsiveness; airway remodeling; asthma; caveolae; caveolin-1; chronic obstructive pulmonary disease; fibrosis; inflammation; lung