title: The age effect on the association between the scavenger receptor class B type I (SR-BI) polymorphism and HDL-C level: Tehran Lipid and Glucose Study.
abstract: BACKGROUND
  The scavenger receptor class B type I (SR-BI) is a key component in the reverse cholesterol transportation. The aim of this study was to assess the association between exon1 (G → A) polymorphism of SR-BI gene and lipid profiles among the Tehran Lipid and Glucose Study (TLGS) population.
  
  
  METHODS
  This cross-sectional study included 774 adults (322 males and 452 females) aged 20-70 years who were randomly selected from among TLGS population. Anthropometrical and biochemical variables for participants were measured. Selected SR-BI gene polymorphism was determined with restriction fragment length polymorphism, via Alu restriction enzyme.
  
  
  RESULTS
  Minor allele frequency for SR-BI polymorphism in the selected population was 0.159. Allele frequencies were in conformity with Hardy-Weinberg equilibrium. Association between (G → A) SR-BI polymorphism and high density lipoprotein cholesterol (HDL-C) and HDL3 was significant only after adjustment for age as a potential covariate (p = 0.046, 0.041, respectively); however, the results did not improve after adjustment for sex.
  
  
  CONCLUSIONS
  The result of this study confirms the role of age as a potential confounder which could modify the association between the SR-BI single nucleotide polymorphism and HDL-C level.
authors.affiliation: Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Science, Shahid Beheshti University of Medical Science , Tehran , Iran .
authors.forename: Bita
authors.initials: B
authors.lastname: Faam
authors.forename: Maryam Sadat
authors.initials: MS
authors.lastname: Daneshpour
authors.forename: Mehdi
authors.initials: M
authors.lastname: Hedayati
authors.forename: Sohrab
authors.initials: S
authors.lastname: Halalkhor
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Mansournia
authors.forename: Maryam
authors.initials: M
authors.lastname: Zarkesh
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D018955:CD36 Antigens / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D018955:CD36 Antigens; D008076:Cholesterol, HDL
keywords: HDL-C; SR-BI gene; TLGS; polymorphism