title: Antibody humanization methods for development of therapeutic applications.
abstract: Recombinant antibody technologies are rapidly becoming available and showing considerable clinical success. However, the immunogenicity of murine-derived monoclonal antibodies is restrictive in cancer immunotherapy. Humanized antibodies can overcome these problems and are considered to be a promising alternative therapeutic agent. There are several approaches for antibody humanization. In this article we review various methods used in the antibody humanization process.
authors.affiliation: 1 Biotechnology Research Center, Tabriz University of Medical Sciences , Tabriz, Iran .
authors.forename: Vahideh
authors.initials: V
authors.lastname: Ahmadzadeh
authors.forename: Safar
authors.initials: S
authors.lastname: Farajnia
authors.forename: Mohammad Ali Hosseinpour
authors.initials: MA
authors.lastname: Feizi
authors.forename: Ramezan Ali Khavari
authors.initials: RA
authors.lastname: Nejad
mesh_terms: D019943:Amino Acid Substitution; D000818:Animals; D061067:Antibodies, Monoclonal, Humanized / Q000096:biosynthesis / Q000235:genetics* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D022801:Complementarity Determining Regions / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D015202:Protein Engineering / Q000379:methods*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D022801:Complementarity Determining Regions