title: Potential use of a megamolecular polysaccharide sacran as a hydrogel-based sustained release system.
abstract: A megamolecular polysaccharide sacran was newly extracted from cyanobacterium Aphanothece sacrum. Sacran has many preferable properties for transdermal application, e.g. a safe biomaterial, a high moisturizing effect, a formation of film and hydrogel. Additionally, it was recently discovered that sacran has an anti-inflammatory effect for atopic dermatitis model mice. In this study, in order to evaluate the feasibility of sacran-hydrogel as a novel sustained release system, we prepared a sacran-hydrogel containing 4-biphenyl acetic acid (BPAA, an acidic drug), prednisolone (PD, a neutral drug) or chlorpheniramine maleate (CPM, a basic drug), and performed the in vitro release studies. The sacran-hydrogel containing BPAA, PD or CPM provided a sustained release profile in accordance with a quasi-Fickian diffusion model. Furthermore, the release rate of drugs from sacran-hydrogels can be controlled by adjusting the concentration of aluminum chloride as a cross linker. These results suggest the potential use of sacran-hydrogel as a sustained release system for drugs.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Motoyama
authors.forename: Yuki
authors.initials: Y
authors.lastname: Tanida
authors.forename: Kyona
authors.initials: K
authors.lastname: Hata
authors.forename: Tomoya
authors.initials: T
authors.lastname: Hayashi
authors.forename: Taishi
authors.initials: T
authors.lastname: Higashi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ishitsuka
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kondo
authors.forename: Tetsumi
authors.initials: T
authors.lastname: Irie
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kaneko
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Arima
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D002744:Chlorpheniramine / Q000737:chemistry / Q000378:metabolism; D000458:Cyanobacteria / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000378:metabolism; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D010648:Phenylacetates / Q000737:chemistry / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry* / Q000378:metabolism; D011239:Prednisolone / Q000737:chemistry / Q000378:metabolism
chemical_list: D017607:Aluminum Compounds; D001672:Biocompatible Materials; D002712:Chlorides; D003692:Delayed-Action Preparations; D010648:Phenylacetates; D011134:Polysaccharides; C571099:sacran; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D000077410:Aluminum Chloride; D002744:Chlorpheniramine; C012776:biphenylylacetic acid; D011239:Prednisolone