title: Outbreak of contact sensitization to methylisothiazolinone: an analysis of French data from the REVIDAL-GERDA network.
abstract: BACKGROUND
  The preservative methylisothiazolinone (MI) is used in combination with methylchloroisothiazolinone (MCI), but the MCI/MI mixture has been identified as highly allergenic. MI is considered to be less allergenic, and since the mid-2000s has been widely used alone, but is now clearly identified as a contact allergen. The French Vigilance Network for Dermatology and Allergy of the Study and Research Group on Contact Dermatitis (REVIDAL-GERDA) added MI to its baseline patch testing series in 2010.
  
  
  OBJECTIVE
  To evaluate the change in the proportion of MI-positive tests in France between 2010 and 2012.
  
  
  METHODS
  We conducted a nationwide, multicentre, retrospective study of all MI-tested patients between 2010 and 2012.
  
  
  RESULTS
  Sixteen centres participated in the study (7874 patients were tested). Patch tests were performed mainly at a concentration of MI 200 ppm aq. We observed a significant increase in the proportion of MI-positive tests in 2012 and 2011 as compared with 2010 (5.6%, 3.3%, and 1.5%, respectively; p < 0.001).
  
  
  CONCLUSIONS
  We report a significant increase in the number of MI-positive tests. MI is confirmed to be a rapidly emerging allergen, as also observed in other European countries.
authors.affiliation: Department of Dermatology, Larrey Hospital, Paul Sabatier University, 31059, Toulouse, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Hosteing
authors.forename: Nicolas
authors.initials: N
authors.lastname: Meyer
authors.forename: Julie
authors.initials: J
authors.lastname: Waton
authors.forename: Annick
authors.initials: A
authors.lastname: Barbaud
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Bourrain
authors.forename: Nadia
authors.initials: N
authors.lastname: Raison-Peyron
authors.forename: Brigitte
authors.initials: B
authors.lastname: Felix
authors.forename: Brigitte
authors.initials: B
authors.lastname: Milpied-Homsi
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Ferrier Le Bouedec
authors.forename: Michel
authors.initials: M
authors.lastname: Castelain
authors.forename: Dominique
authors.initials: D
authors.lastname: Vital-Durand
authors.forename: Michèle
authors.initials: M
authors.lastname: Debons
authors.forename: Evelyne
authors.initials: E
authors.lastname: Collet
authors.forename: Martine
authors.initials: M
authors.lastname: Avenel-Audran
authors.forename: Pascale
authors.initials: P
authors.lastname: Mathelier-Fusade
authors.forename: Christophe
authors.initials: C
authors.lastname: Vermeulen
authors.forename: Haudrey
authors.initials: H
authors.lastname: Assier
authors.forename: Gwendoline
authors.initials: G
authors.lastname: Gener
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lartigau-Sezary
authors.forename: Amandine
authors.initials: A
authors.lastname: Catelain-Lamy
authors.forename: Françoise
authors.initials: F
authors.lastname: Giordano-Labadie
mesh_terms: D000328:Adult; D003358:Cosmetics / Q000009:adverse effects / Q000737:chemistry; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology; D004196:Disease Outbreaks; D005188:False Negative Reactions; D005260:Female; D005602:France / Q000453:epidemiology; D006795:Household Products / Q000009:adverse effects; D006801:Humans; D008297:Male; D010328:Patch Tests; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D012189:Retrospective Studies; D013844:Thiazoles / Q000009:adverse effects*
chemical_list: D003358:Cosmetics; D011310:Preservatives, Pharmaceutical; D013844:Thiazoles; C011506:2-methyl-4-isothiazolin-3-one; C011421:5-chloro-2-methyl-4-isothiazolin-3-one
keywords: France; REVIDAL-GERDA; contact dermatitis; cosmetics; methylchloroisothiazolinone; methylisothiazolinone; preservative; sensitization