title: The role of viral persistence in flavivirus biology.
abstract: In nature, vector-borne flaviviruses are persistently cycled between either the tick or mosquito vector and small mammals such as rodents, skunks, and swine. These viruses account for considerable human morbidity and mortality worldwide. Increasing and substantial evidence of viral persistence in humans, which includes the isolation of RNA by RT-PCR and infectious virus by culture, continues to be reported. Viral persistence can also be established in vitro in various human, animal, arachnid, and insect cell lines in culture. Although some research has focused on the potential roles of defective virus particles, evasion of the immune response through the manipulation of autophagy and/or apoptosis, the precise mechanism of flavivirus persistence is still not well understood. We propose additional research for further understanding of how viral persistence is established in different systems. Avenues for additional studies include determining whether the multifunctional flavivirus protein NS5 has a role in viral persistence, the development of relevant animal models of viral persistence, and investigating the host responses that allow vector-borne flavivirus replication without detrimental effects on infected cells. Such studies might shed more light on the viral-host relationships and could be used to unravel the mechanisms for establishment of persistence.
authors.affiliation: Rocky Mountain Laboratories, Laboratory of Virology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
authors.forename: Luwanika
authors.initials: L
authors.lastname: Mlera
authors.forename: Wessam
authors.initials: W
authors.lastname: Melik
authors.forename: Marshall E
authors.initials: ME
authors.lastname: Bloom
mesh_terms: D000818:Animals; D002353:Carrier State / Q000821:virology*; D004195:Disease Models, Animal; D005416:Flavivirus / Q000502:physiology*; D018177:Flavivirus Infections / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans
keywords: arboviruses; vector-borne flaviviruses; viral persistence
references.citation: Virology. 1973 Nov;56(1):70-87
references.pmid: 4583310
references.citation: Wien Med Wochenschr. 2012 Jun;162(11-12):230-8
references.pmid: 22699708
references.citation: J Clin Virol. 2008 Sep;43(1):102-6
references.pmid: 18467165
references.citation: J Virol. 2005 Jul;79(13):8339-47
references.pmid: 15956579
references.citation: J Virol. 2005 Oct;79(20):12828-39
references.pmid: 16188985
references.citation: EMBO J. 2004 Feb 25;23(4):728-38
references.pmid: 14963486
references.citation: J Parasitol. 1994 Aug;80(4):533-43
references.pmid: 8064520
references.citation: J Biomed Sci. 2006 Jul;13(4):469-80
references.pmid: 16691359
references.citation: Clin Exp Immunol. 1997 Dec;110(3):358-61
references.pmid: 9409636
references.citation: Virus Res. 2010 Feb;147(2):275-83
references.pmid: 19944121
references.citation: Acta Vet Acad Sci Hung. 1976;26(4):419-37
references.pmid: 1052657
references.citation: Vaccine. 2013 Jan 7;31(3):461-71
references.pmid: 23153447
references.citation: Adv Virus Res. 2003;59:99-140
references.pmid: 14696328
references.citation: J Med Entomol. 1993 Jan;30(1):295-9
references.pmid: 8433342
references.citation: J Biol Chem. 2007 Mar 23;282(12):8873-82
references.pmid: 17276984
references.citation: J Virol. 2005 Sep;79(18):11813-23
references.pmid: 16140758
references.citation: J Wildl Dis. 1979 Oct;15(4):585-91
references.pmid: 230364
references.citation: Cell. 2002 Mar 8;108(5):717-25
references.pmid: 11893341
references.citation: J Virol. 2008 Aug;82(16):7846-62
references.pmid: 18524814
references.citation: J Virol. 1998 Mar;72(3):2132-40
references.pmid: 9499069
references.citation: Virology. 2010 Sep 15;405(1):243-52
references.pmid: 20594569
references.citation: J Virol. 1991 Nov;65(11):6042-50
references.pmid: 1833562
references.citation: J Gen Virol. 2009 Aug;90(Pt 8):1781-1794
references.pmid: 19420159
references.citation: Emerg Infect Dis. 2013 Dec;19(12):2012-6
references.pmid: 24274336
references.citation: Appl Environ Microbiol. 2011 Mar;77(6):1999-2007
references.pmid: 21257811
references.citation: Am J Trop Med Hyg. 2005 May;72(5):622-30
references.pmid: 15891139
references.citation: J Virol. 1998 Mar;72(3):2474-82
references.pmid: 9499109
references.citation: Virus Res. 2009 Jul;143(1):77-85
references.pmid: 19463724
references.citation: J Gen Virol. 1991 Nov;72 ( Pt 11):2705-11
references.pmid: 1940867
references.citation: Ochsner J. 2003 Summer;5(3):18-20
references.pmid: 21765765
references.citation: Antiviral Res. 2004 Jul;63(1):41-50
references.pmid: 15196819
references.citation: J Virol. 2006 Mar;80(6):2913-23
references.pmid: 16501100
references.citation: J Virol. 2002 Jun;76(11):5480-91
references.pmid: 11991976
references.citation: Adv Virus Res. 2007;69:203-48
references.pmid: 17222695
references.citation: J Virol. 2005 Jun;79(11):6631-43
references.pmid: 15890901
references.citation: Chin Med J (Engl). 2002 Sep;115(9):1324-7
references.pmid: 12411104
references.citation: Clin Microbiol Rev. 2012 Oct;25(4):635-48
references.pmid: 23034323
references.citation: Viruses. 2011 Feb;3(2):160-71
references.pmid: 22049308
references.citation: Virology. 2008 Sep 15;379(1):64-77
references.pmid: 18667221
references.citation: J Infect Dis. 2010 Jan 1;201(1):2-4
references.pmid: 19961306
references.citation: J Infect Dis. 2011 Feb 1;203(3):344-7
references.pmid: 21208926
references.citation: Virology. 2006 Feb 5;345(1):56-72
references.pmid: 16243374
references.citation: J Virol. 1999 Aug;73(8):6257-64
references.pmid: 10400716
references.citation: J Infect Dis. 2005 Jan 1;191(1):100-8
references.pmid: 15593010
references.citation: Ticks Tick Borne Dis. 2012 Feb;3(1):27-37
references.pmid: 22309856
references.citation: N Engl J Med. 2002 Oct 17;347(16):1280-1
references.pmid: 12270972
references.citation: J Virol. 1990 Sep;64(9):4356-63
references.pmid: 2143542
references.citation: Vector Borne Zoonotic Dis. 2011 Jun;11(6):649-58
references.pmid: 21254926
references.citation: Cell Host Microbe. 2011 Sep 15;10(3):185-96
references.pmid: 21925107
references.citation: J Virol. 2004 Sep;78(17):9285-94
references.pmid: 15308723
references.citation: Biochim Biophys Acta. 2009 Sep-Oct;1789(9-10):495-517
references.pmid: 19781674
references.citation: Virus Res. 1997 May;49(1):27-39
references.pmid: 9178494
references.citation: J Clin Virol. 2004 Dec;31(4):289-91
references.pmid: 15494271
references.citation: Vector Borne Zoonotic Dis. 2004 Summer;4(2):109-22
references.pmid: 15228811
references.citation: J Virol. 2007 Sep;81(18):10172-87
references.pmid: 17626087
references.citation: Science. 2013 Apr 12;340(6129):207-11
references.pmid: 23580529
references.citation: Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10578-83
references.pmid: 10973478
references.citation: J Virol. 2004 Nov;78(22):12225-35
references.pmid: 15507609
references.citation: Am J Trop Med Hyg. 2008 Aug;79(2):267-74
references.pmid: 18689635
references.citation: J Exp Med. 2010 Apr 12;207(4):793-806
references.pmid: 20308361
references.citation: Virology. 2008 Mar 30;373(1):1-13
references.pmid: 18258275
references.citation: J Virol. 2012 Sep;86(18):10015-27
references.pmid: 22787210
references.citation: Emerg Infect Dis. 2002 Dec;8(12):1379-84
references.pmid: 12498651
references.citation: J Gen Virol. 2013 Feb;94(Pt 2):308-313
references.pmid: 23114626
references.citation: Parasit Vectors. 2013 Jul 15;6:185
references.pmid: 24016533
references.citation: J Virol. 2011 Dec;85(24):13409-19
references.pmid: 21976640
references.citation: J Med Entomol. 2005 May;42(3):429-44
references.pmid: 15962797
references.citation: Curr Opin Virol. 2012 Apr;2(2):168-75
references.pmid: 22445964
references.citation: Antiviral Res. 2010 Aug;87(2):125-48
references.pmid: 19945487
references.citation: Gene Ther. 2007 Jun;14(12):960-71
references.pmid: 17377597
references.citation: Vopr Virusol. 1998 Jul-Aug;43(4):182-6
references.pmid: 9791885
references.citation: J Virol. 2004 Aug;78(15):8271-80
references.pmid: 15254199
references.citation: J Gen Virol. 1986 Feb;67 ( Pt 2):381-5
references.pmid: 3003242
references.citation: J Gen Virol. 2006 Oct;87(Pt 10):2791-2801
references.pmid: 16963737
references.citation: J Virol. 2004 Aug;78(15):8312-21
references.pmid: 15254203
references.citation: PLoS One. 2012;7(10):e47912
references.pmid: 23112871
references.citation: J Gen Virol. 2009 Jul;90(Pt 7):1649-1658
references.pmid: 19264624
references.citation: J Virol. 2002 Jun;76(11):5701-10
references.pmid: 11991998
references.citation: J Infect Dis. 2012 May 1;205(9):1476-7
references.pmid: 22438324
references.citation: J Virol. 2003 Oct;77(19):10623-9
references.pmid: 12970446
references.citation: Viruses. 2011 Nov;3(11):2087-126
references.pmid: 22163336
references.citation: Virus Res. 2005 Aug;111(2):161-74
references.pmid: 15871909
references.citation: Virology. 1996 May 15;219(2):357-66
references.pmid: 8638401
references.citation: Virology. 2001 Aug 1;286(2):328-35
references.pmid: 11485400
references.citation: Virology. 2010 Mar 30;399(1):153-166
references.pmid: 20097399
references.citation: J Virol. 1991 Apr;65(4):1863-9
references.pmid: 1840619
references.citation: J Med Virol. 2007 Oct;79(10):1506-17
references.pmid: 17705192
references.citation: J Infect Dis. 2005 Jul 15;192(2):287-95
references.pmid: 15962223
references.citation: Scand J Infect Dis. 1996;28(3):217-24
references.pmid: 8863349
references.citation: Arch Virol. 2009;154(5):783-9
references.pmid: 19347246
references.citation: Arch Virol. 1995;140(1):145-56
references.pmid: 7646339
references.citation: J Gen Virol. 2009 Dec;90(Pt 12):2877-2883
references.pmid: 19675189
references.citation: Am J Trop Med Hyg. 1983 Sep;32(5):1108-19
references.pmid: 6625066
references.citation: J Gen Virol. 2004 Mar;85(Pt 3):615-620
references.pmid: 14993645
references.citation: J Virol. 2005 Feb;79(3):1934-42
references.pmid: 15650219
references.citation: Virol J. 2013 Feb 14;10:58
references.pmid: 23410000
references.citation: PLoS Pathog. 2008 Nov;4(11):e1000172
references.pmid: 19043585
references.citation: J Virol. 2005 Mar;79(6):3448-58
references.pmid: 15731239
references.citation: J Infect Dis. 2006 Apr 15;193(8):1078-88
references.pmid: 16544248
references.citation: J Virol. 1993 Apr;67(4):2327-35
references.pmid: 8445732
references.citation: Acta Virol. 1984 Sep;28(5):407-15
references.pmid: 6151355
references.citation: J Infect Dis. 2010 Dec 15;202(12):1813-8
references.pmid: 21050126
references.citation: J Virol. 1995 Dec;69(12):7519-28
references.pmid: 7494258
references.citation: Cell Microbiol. 2008 Jan;10(1):165-76
references.pmid: 17697133
references.citation: J Biol Chem. 2006 Mar 31;281(13):8854-63
references.pmid: 16436383
references.citation: Am J Trop Med Hyg. 2008 Dec;79(6):971-3
references.pmid: 19052313
references.citation: Virology. 1996 Oct 15;224(2):437-45
references.pmid: 8874504
references.citation: Virol J. 2009 Feb 05;6:14
references.pmid: 19196463
references.citation: J Biol Chem. 2007 Apr 6;282(14):10678-89
references.pmid: 17287213
references.citation: J Antimicrob Chemother. 2012 Aug;67(8):1884-94
references.pmid: 22535622
references.citation: Euro Surveill. 2012 Mar 22;17(12):
references.pmid: 22490310
references.citation: Mol Med Rep. 2013 Mar;7(3):826-30
references.pmid: 23291778
references.citation: Virology. 1982 Jan 15;116(1):84-98
references.pmid: 6175076
references.citation: J Virol. 2006 Mar;80(5):2396-404
references.pmid: 16474146
references.citation: Virus Res. 2009 Feb;139(2):230-9
references.pmid: 18703097
references.citation: Virology. 2000 Sep 1;274(2):292-308
references.pmid: 10964773
references.citation: Am J Trop Med Hyg. 2009 Jan;80(1):85-95
references.pmid: 19141845
references.citation: Emerg Infect Dis. 2008 Jun;14(6):962-5
references.pmid: 18507915
references.citation: Parasit Vectors. 2012 Aug 31;5:184
references.pmid: 22937961
references.citation: J Virol. 2011 Jul;85(13):6736-49
references.pmid: 21525349
references.citation: Adv Virus Res. 2003;60:187-232
references.pmid: 14689695
references.citation: Acta Virol. 1981 Nov;25(6):337-43
references.pmid: 6120634
references.citation: Emerg Infect Dis. 1997 Apr-Jun;3(2):165-70
references.pmid: 9204297
references.citation: Curr Opin Virol. 2011 Sep;1(3):160-6
references.pmid: 21909344
references.citation: Folia Parasitol (Praha). 1984;31(2):187-9
references.pmid: 6745800
references.citation: Annu Rev Microbiol. 1990;44:649-88
references.pmid: 2174669
references.citation: Virology. 2005 Apr 25;335(1):72-86
references.pmid: 15823607
references.citation: Nat Med. 2004 Dec;10(12 Suppl):S98-109
references.pmid: 15577938
references.citation: Arch Virol Suppl. 2004;(18):35-41
references.pmid: 15119761
references.citation: Vestn Akad Med Nauk SSSR. 1983;(5):67-73
references.pmid: 6868808
references.citation: Hum Pathol. 2004 Aug;35(8):983-90
references.pmid: 15297965
references.citation: J Gen Virol. 2011 Aug;92(Pt 8):1906-1916
references.pmid: 21593276
references.citation: J Virol. 2010 Jun;84(12):6103-18
references.pmid: 20357095
references.citation: Vet Pathol. 2010 Sep;47(5):806-18
references.pmid: 20551474
references.citation: J Biol Chem. 2011 Jun 24;286(25):22147-59
references.pmid: 21511946
references.citation: Cell Microbiol. 2008 Mar;10(3):696-712
references.pmid: 18042258
references.citation: Clin Infect Dis. 2013 Jul;57(1):157-8
references.pmid: 23487381
references.citation: J Virol. 2010 Feb;84(3):1641-7
references.pmid: 19906906
references.citation: J Virol. 2006 Nov;80(22):11000-8
references.pmid: 16943291
references.citation: J Virol. 1977 Nov;24(2):580-9
references.pmid: 916028
references.citation: Cell Host Microbe. 2009 Apr 23;5(4):365-75
references.pmid: 19380115
references.citation: Crit Rev Clin Lab Sci. 2004;41(4):391-427
references.pmid: 15487593
references.citation: Nat Struct Mol Biol. 2006 Apr;13(4):372-3
references.pmid: 16532006
references.citation: J Gen Virol. 2001 Apr;82(Pt 4):735-745
references.pmid: 11257177
references.citation: Intervirology. 2001;44(1):48-54
references.pmid: 11223720
references.citation: Neurol India. 2010 Jul-Aug;58(4):585-91
references.pmid: 20739797
references.citation: J Clin Virol. 2012 Jun;54(2):115-20
references.pmid: 22421535
references.citation: Virology. 2009 Feb 5;384(1):242-52
references.pmid: 19062063
references.citation: J Virol. 2013 Apr;87(8):4778-82
references.pmid: 23388711
references.citation: Cell Host Microbe. 2010 Feb 18;7(2):85-6
references.pmid: 20159612
references.citation: J Vet Med Sci. 2010 Apr;72(4):391-6
references.pmid: 19996560
references.citation: J Virol. 2007 May;81(9):4753-65
references.pmid: 17301146
references.citation: Viruses. 2013 Dec 30;6(1):69-88
references.pmid: 24381034
references.citation: Adv Virus Res. 2003;60:233-72
references.pmid: 14689696
references.citation: J Virol. 2006 Apr;80(8):4099-113
references.pmid: 16571826
references.citation: Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14333-8
references.pmid: 14612562
references.citation: J Virol. 2002 Feb;76(4):1932-43
references.pmid: 11799188
references.citation: Virus Res. 2006 Jan;115(1):1-8
references.pmid: 16102869
references.citation: Am J Trop Med Hyg. 2005 Oct;73(4):803-7
references.pmid: 16222029
references.citation: PLoS Pathog. 2009 Feb;5(2):e1000299
references.pmid: 19214215
references.citation: Curr Top Microbiol Immunol. 2005;287:95-131
references.pmid: 15609510
references.citation: Virus Res. 1999 Mar;60(1):67-79
references.pmid: 10225275
references.citation: Ticks Tick Borne Dis. 2012 Feb;3(1):18-26
references.pmid: 22309855
references.citation: Proc Natl Acad Sci U S A. 2011 May 10;108(19):8003-8
references.pmid: 21518917
references.citation: J Virol. 2006 May;80(9):4623-32
references.pmid: 16611922
references.citation: Virology. 2007 Feb 20;358(2):258-65
references.pmid: 17067651
references.citation: J Virol. 2006 Dec;80(23):11467-74
references.pmid: 16987985
references.citation: J Virol. 2010 Sep;84(17):8470-83
references.pmid: 20554782
references.citation: Clin Infect Dis. 2006 Sep 15;43(6):723-30
references.pmid: 16912946
references.citation: Virology. 2012 May 25;427(1):10-7
references.pmid: 22365325
references.citation: J Clin Exp Neuropsychol. 2010 Jan;32(1):81-7
references.pmid: 19513920
references.citation: EMBO J. 2003 Jun 2;22(11):2604-13
references.pmid: 12773377
references.citation: J Virol. 2003 Jan;77(1):25-36
references.pmid: 12477807
references.citation: J Virol. 1998 Dec;72(12):9844-54
references.pmid: 9811720
references.citation: Emerg Infect Dis. 2006 Dec;12(12):1982-4
references.pmid: 17326959
references.citation: Vet Microbiol. 2013 Sep 27;166(1-2):11-21
references.pmid: 23755934
references.citation: Vector Borne Zoonotic Dis. 2010 Apr;10(3):267-74
references.pmid: 19619041
references.citation: J Infect Dis. 2008 Oct 1;198(7):984-93
references.pmid: 18729783
references.citation: Virology. 1998 Jun 5;245(2):203-15
references.pmid: 9636360
references.citation: Annu Rev Entomol. 2009;54:17-35
references.pmid: 19067628
references.citation: Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91
references.pmid: 12759475
references.citation: Genes Dev. 2006 Aug 15;20(16):2238-49
references.pmid: 16882970
references.citation: Emerg Infect Dis. 2003 Jul;9(7):887-9
references.pmid: 12899140
references.citation: Vector Borne Zoonotic Dis. 2011 Jun;11(6):641-7
references.pmid: 21548766
references.citation: J Gen Virol. 1996 Jul;77 ( Pt 7):1449-55
references.pmid: 8757986
references.citation: J Virol. 2005 Jul;79(13):8004-13
references.pmid: 15956546
references.citation: J Gen Virol. 1997 Nov;78 ( Pt 11):2711-22
references.pmid: 9367356
references.citation: Vaccine. 2003 Apr 1;21 Suppl 1:S11-8
references.pmid: 12628810
references.citation: J Virol. 2005 Jan;79(2):1223-31
references.pmid: 15613349
references.citation: Transfusion. 2006 Dec;46(12):2038-46
references.pmid: 17176314
references.citation: Virology. 1994 Jan;198(1):109-17
references.pmid: 8259646
references.citation: Ecohealth. 2010 Dec;7(4):439-47
references.pmid: 21125307
references.citation: Structure. 2004 Sep;12(9):1607-18
references.pmid: 15341726
references.citation: J Thromb Haemost. 2007 Nov;5(11):2291-9
references.pmid: 17958746
references.citation: J Med Virol. 1993 Aug;40(4):326-9
references.pmid: 8228925
references.citation: N Engl J Med. 2003 Sep 25;349(13):1236-45
references.pmid: 14500806
references.citation: Parasit Vectors. 2010 Mar 19;3(1):19
references.pmid: 20302617
references.citation: J Virol. 2009 Jan;83(2):993-1008
references.pmid: 19004935
references.citation: Med Vet Entomol. 1993 Oct;7(4):339-42
references.pmid: 8268488
references.citation: Emerg Infect Dis. 2013 May;19(5):806-8
references.pmid: 23697658
references.citation: Clin Infect Dis. 2006 Mar 1;42(5):680-3
references.pmid: 16447115
references.citation: J Gen Virol. 2003 Aug;84(Pt 8):2191-2195
references.pmid: 12867651
references.citation: Clin Microbiol Rev. 2009 Oct;22(4):564-81
references.pmid: 19822889
references.citation: Clin Exp Immunol. 1991 Jul;85(1):85-9
references.pmid: 1649022
references.citation: Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Feb 1;62(Pt 2):157-62
references.pmid: 16511290
references.citation: J Gen Virol. 1997 Jan;78 ( Pt 1):23-9
references.pmid: 9010281
references.citation: J Virol. 1999 Dec;73(12):10113-21
references.pmid: 10559326
references.citation: J Virol. 1991 May;65(5):2467-75
references.pmid: 2016768
references.citation: J Gen Virol. 1995 Feb;76 ( Pt 2):381-91
references.pmid: 7531218
references.citation: J Virol. 2007 Dec;81(23):12816-26
references.pmid: 17881453
references.citation: J Virol. 1990 Oct;64(10):5156-9
references.pmid: 2398538
references.citation: Biochem Biophys Res Commun. 2009 Jul 24;385(2):187-92
references.pmid: 19450550
references.citation: Trends Microbiol. 2000 Feb;8(2):61-7
references.pmid: 10664598
references.citation: Int J Parasitol. 2012 Apr;42(4):365-72
references.pmid: 22464896
references.citation: MMWR Morb Mortal Wkly Rep. 2009 Nov 20;58(45):1263-7
references.pmid: 19940831
references.citation: Arch Virol. 2004 Oct;149(10):1955-70
references.pmid: 15669107
references.citation: J Gen Virol. 1991 Mar;72 ( Pt 3):573-8
references.pmid: 1848592
references.citation: Clin Med Res. 2003 Apr;1(2):145-50
references.pmid: 15931302
references.citation: Zh Mikrobiol Epidemiol Immunobiol. 1997 May-Jun;(3):33-6
references.pmid: 9304324
references.citation: Clin Vaccine Immunol. 2006 Jun;13(6):711-4
references.pmid: 16760333
references.citation: J Virol. 2005 May;79(10):6172-9
references.pmid: 15858002
references.citation: Virus Res. 2006 Mar;116(1-2):106-13
references.pmid: 16289409
references.citation: Annu Rev Entomol. 2010;55:95-110
references.pmid: 19961325
references.citation: PLoS Pathog. 2012 Sep;8(9):e1002913
references.pmid: 22969431
references.citation: Emerg Infect Dis. 2001 Jul-Aug;7(4):714-21
references.pmid: 11585537
references.citation: J Biol Chem. 2006 Oct 6;281(40):30166-74
references.pmid: 16882664
references.citation: J Virol. 1997 May;71(5):3466-73
references.pmid: 9094618
references.citation: BMC Immunol. 2011 Jan 20;12:6
references.pmid: 21251256
references.citation: Med Parazitol (Mosk). 1991 May-Jun;(3):54-6
references.pmid: 1770888
references.citation: J Virol Methods. 2005 Jun;126(1-2):101-9
references.pmid: 15847925
references.citation: J Virol. 2007 Nov;81(21):11809-16
references.pmid: 17715229
references.citation: Am J Trop Med Hyg. 2012 Sep;87(3):559-64
references.pmid: 22826479
references.citation: EMBO J. 2002 Jun 3;21(11):2757-68
references.pmid: 12032088
references.citation: J Wildl Dis. 2006 Jan;42(1):14-22
references.pmid: 16699144
references.citation: Cell Biochem Funct. 2007 Mar-Apr;25(2):185-8
references.pmid: 16312014
references.citation: J Wildl Dis. 2005 Jan;41(1):96-106
references.pmid: 15827215
references.citation: Immunol Cell Biol. 2003 Jun;81(3):196-206
references.pmid: 12752684
references.citation: Emerg Infect Dis. 2007 Jan;13(1):153-5
references.pmid: 17370534
references.citation: Nucleic Acids Res. 2011 Sep 1;39(16):7034-48
references.pmid: 21622960
references.citation: Vector Borne Zoonotic Dis. 2012 Mar;12(3):236-42
references.pmid: 22022821
references.citation: J Gen Virol. 1998 Oct;79 ( Pt 10):2375-80
references.pmid: 9780042
references.citation: Am J Pathol. 1987 Sep;128(3):455-63
references.pmid: 2957924
references.citation: J Gen Virol. 1998 May;79 ( Pt 5):947-59
references.pmid: 9603310
references.citation: Arch Virol. 1983;75(1-2):71-86
references.pmid: 6299247
references.citation: Br J Exp Pathol. 1971 Aug;52(4):395-407
references.pmid: 4936536
references.citation: Vet Pathol. 2000 May;37(3):208-24
references.pmid: 10810985
references.citation: Antiviral Res. 2004 Aug;63(2):67-77
references.pmid: 15321702
references.citation: Curr Opin Virol. 2013 Feb;3(1):3-12
references.pmid: 23352692
references.citation: J Virol. 2002 Apr;76(7):3534-43
references.pmid: 11884577
references.citation: Lancet. 1998 Apr 11;351(9109):1094-7
references.pmid: 9660579
references.citation: Curr Top Microbiol Immunol. 2002;267:139-52
references.pmid: 12082987
references.citation: J Neuroinflammation. 2013 Jun 27;10:77
references.pmid: 23805778
references.citation: J Gen Virol. 2011 May;92(Pt 5):1199-1204
references.pmid: 21289157
references.citation: J Gen Virol. 2004 Jul;85(Pt 7):1971-1980
references.pmid: 15218182
references.citation: J Virol. 1998 Jan;72(1):624-32
references.pmid: 9420267
references.citation: J Infect Dis. 2009 Oct 15;200(8):1261-70
references.pmid: 19754307
references.citation: J Virol. 2002 Dec;76(24):13097-100
references.pmid: 12438639
references.citation: Curr Top Microbiol Immunol. 2002;267:1-10
references.pmid: 12082984
references.citation: Virus Res. 2001 Aug;76(2):161-9
references.pmid: 11410315
references.citation: Virology. 2007 Sep 1;365(2):410-8
references.pmid: 17490700
references.citation: J Virol. 2010 Oct;84(20):10438-47
references.pmid: 20686019
references.citation: Am J Trop Med Hyg. 2004 Jul;71(1):112-9
references.pmid: 15238699
references.citation: Proc Biol Sci. 2006 Sep 22;273(1599):2327-33
references.pmid: 16928635
references.citation: PLoS One. 2011 Apr 29;6(4):e19447
references.pmid: 21559384
references.citation: Clin Infect Dis. 2001 Nov 15;33(10):1713-9
references.pmid: 11595987
references.citation: Viruses. 2013 Dec 27;6(1):13-53
references.pmid: 24378320
references.citation: J Virol. 2009 Feb;83(3):1299-311
references.pmid: 19036819
references.citation: J Virol. 2011 Feb;85(4):1900-5
references.pmid: 21123391
references.citation: PLoS Negl Trop Dis. 2013 Jun 13;7(6):e2275
references.pmid: 23785537
references.citation: PLoS One. 2013;8(1):e55006
references.pmid: 23383032
references.citation: J Mol Biol. 1987 Nov 5;198(1):33-41
references.pmid: 2828633
references.citation: Traffic. 2007 Jul;8(7):795-807
references.pmid: 17537211
references.citation: Vaccine. 2004 Jul 29;22(21-22):2743-9
references.pmid: 15246606
references.citation: J Biol Chem. 2002 Sep 27;277(39):36399-407
references.pmid: 12105224
references.citation: Adv Virus Res. 2003;59:177-228
references.pmid: 14696330
references.citation: J Virol. 1997 Sep;71(9):6650-61
references.pmid: 9261387
references.citation: J Biol Chem. 2009 Jun 5;284(23):15589-97
references.pmid: 19297323
references.citation: J Virol. 1985 Aug;55(2):366-73
references.pmid: 2991562
references.citation: Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4285-90
references.pmid: 24594604
references.citation: Virology. 1991 Mar;181(1):70-7
references.pmid: 1704661
references.citation: Virology. 1996 Mar 1;217(1):220-9
references.pmid: 8599206
references.citation: J Virol. 2003 Jun;77(12):7143-9
references.pmid: 12768036
references.citation: J Clin Microbiol. 2009 Apr;47(4):927-31
references.pmid: 19225099
references.citation: Nature. 1995 May 25;375(6529):291-8
references.pmid: 7753193
references.citation: J Gen Virol. 1996 Oct;77 ( Pt 10):2541-5
references.pmid: 8887488
references.citation: J Virol. 2005 Jul;79(13):8388-99
references.pmid: 15956583
references.citation: Immunol Res. 2009;43(1-3):172-86
references.pmid: 18841330
references.citation: Virus Res. 2011 Mar;156(1-2):25-34
references.pmid: 21195733
references.citation: Am J Trop Med Hyg. 2007 Feb;76(2):299-306
references.pmid: 17297039
references.citation: J Gen Virol. 2010 Jan;91(Pt 1):87-94
references.pmid: 19741066
references.citation: Am J Trop Med Hyg. 2005 Mar;72(3):320-4
references.pmid: 15772329
references.citation: Virology. 2001 Apr 10;282(2):288-300
references.pmid: 11289811
references.citation: Emerg Infect Dis. 2003 Mar;9(3):311-22
references.pmid: 12643825
references.citation: J Virol. 2009 Dec;83(24):12895-906
references.pmid: 19793813
references.citation: Am J Trop Med Hyg. 1981 Nov;30(6):1319-23
references.pmid: 6275728
references.citation: J Virol. 2007 Jul;81(13):6936-46
references.pmid: 17459929
references.citation: Adv Virus Res. 2003;60:43-85
references.pmid: 14689691
references.citation: Antiviral Res. 2008 Nov;80(2):94-101
references.pmid: 18674567
references.citation: J Gen Virol. 1986 May;67 ( Pt 5):945-7
references.pmid: 3009693
references.citation: Indian J Med Res. 1969 May;57(5):805-8
references.pmid: 5820428
references.citation: Trop Med Int Health. 2007 Sep;12(9):1087-95
references.pmid: 17875019
references.citation: PLoS One. 2010 May 14;5(5):e10649
references.pmid: 20498839