title: The Association Between JAK2V617F Mutation and Bone Marrow Fibrosis at Diagnosis in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms.
abstract: OBJECTIVE
  Bone marrow fibrosis is the second most common complication that causes morbidity and mortality inpatients with Philadelphia-negative myeloproliferative neoplasms (MPNs). The aim of this study was to investigate theassociation between JAK2V617F mutation and bone marrow fibrosis at diagnosis in patients with MPNs.
  
  
  METHODS
  In total, 149 patients with MPNs were retrospectively evaluated to determine if there was anassociation between the histological grade of bone marrow fibrosis and JAK2V617F mutation.
  
  
  RESULTS
  In all, 67.7% of the patients carried the mutated JAK2 gene. The presence of JAK2V617F mutation was notassociated with the occurrence of bone marrow fibrosis (P=0.55) or its grade at diagnosis (P=0.65).
  
  
  CONCLUSIONS
  Molecular mechanisms or genetic defects other than JAK2V617F may underlie the occurrence of bonemarrow fibrosis in patients with MPNs.
authors.affiliation: İstanbul Training and Research Hospital, Department of Hematology, İstanbul, Turkey.
authors.forename: M Cem
authors.initials: MC
authors.lastname: Arı
authors.affiliation: İstanbul University, Cerrahpaşa Medical School, Department of Internal Medicine, İstanbul, Turkey.
authors.forename: Deram
authors.initials: D
authors.lastname: Büyüktaş
authors.affiliation: Diyarbakır Training and Research Hospital, Department of Hematology, Diyarbakır, Turkey.
authors.forename: A Emre
authors.initials: AE
authors.lastname: Eşkazan
authors.affiliation: 4İstanbul University, Cerrahpaşa Medical School, Department of Internal Medicine, Division of Hematology, İstanbul, Turkey.
authors.forename: Seniz
authors.initials: S
authors.lastname: Ongören Aydın
authors.affiliation: İstanbul University, Cerrahpaşa Medical School, Department of Internal Medicine, İstanbul, Turkey.
authors.forename: Eda
authors.initials: E
authors.lastname: Tanrıkulu
authors.affiliation: 4İstanbul University, Cerrahpaşa Medical School, Department of Internal Medicine, Division of Hematology, İstanbul, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Başlar
authors.affiliation: İstanbul University, Cerrahpaşa Medical School, Department of Medical Biology, İstanbul, Turkey.
authors.forename: A Nur
authors.initials: AN
authors.lastname: Buyru
authors.affiliation: 4İstanbul University, Cerrahpaşa Medical School, Department of Internal Medicine, Division of Hematology, İstanbul, Turkey.
authors.forename: Burhan
authors.initials: B
authors.lastname: Ferhanoğlu
authors.affiliation: 4İstanbul University, Cerrahpaşa Medical School, Department of Internal Medicine, Division of Hematology, İstanbul, Turkey.
authors.forename: Yıldız
authors.initials: Y
authors.lastname: Aydın
authors.affiliation: İstanbul University, Cerrahpaşa Medical School, Department of Pathology, İstanbul, Turkey.
authors.forename: Nükhet
authors.initials: N
authors.lastname: Tüzüner
authors.affiliation: 4İstanbul University, Cerrahpaşa Medical School, Department of Internal Medicine, Division of Hematology, İstanbul, Turkey.
authors.forename: Teoman
authors.initials: T
authors.lastname: Soysal
keywords: Bone marrow fibrosis; JAK2V617F; Myeloproliferative disease
references.citation: Nucleic Acids Res. 1988 Feb 11;16(3):1215
references.pmid: 3344216
references.citation: Blood. 2005 Nov 15;106(10):3374-6
references.pmid: 16081684
references.citation: N Engl J Med. 2000 Apr 27;342(17):1255-65
references.pmid: 10781623
references.citation: Acta Haematol. 2005;113(2):137-43
references.pmid: 15802893
references.citation: Leuk Res. 2009 Sep;33(9):1156-7
references.pmid: 19450878
references.citation: J Clin Oncol. 2009 Jun 20;27(18):2991-9
references.pmid: 19364963
references.citation: Lancet. 2005 Mar 19-25;365(9464):1054-61
references.pmid: 15781101
references.citation: Blood. 2012 Mar 8;119(10):2239-41
references.pmid: 22246040
references.citation: Nature. 2005 Apr 28;434(7037):1144-8
references.pmid: 15793561
references.citation: Leukemia. 2008 May;22(5):905-14
references.pmid: 18385755
references.citation: Blood. 2007 Aug 15;110(4):1092-7
references.pmid: 17488875
references.citation: Am J Clin Pathol. 1971 Jul;56(1):24-31
references.pmid: 5556211
references.citation: N Engl J Med. 2010 Sep 16;363(12):1117-27
references.pmid: 20843246
references.citation: Br J Haematol. 2005 Nov;131(3):320-8
references.pmid: 16225651
references.citation: Blood. 2006 May 1;107(9):3676-82
references.pmid: 16373657
references.citation: Curr Opin Hematol. 2006 Mar;13(2):87-92
references.pmid: 16456374
references.citation: Cancer. 2006 Feb 1;106(3):631-5
references.pmid: 16369984
references.citation: N Engl J Med. 2005 Apr 28;352(17):1779-90
references.pmid: 15858187