title: Hepcidin and sports anemia.
abstract: Iron is an important mineral element used by the body in a variety of metabolic and physiologic processes. These processes are highly active when the body is undergoing physical exercises. Prevalence of exercise-induced iron deficiency anemia (also known as sports anemia) is notably high in athletic populations, particularly those with heavy training loads. The pathogenesis of sports anemia is closely related to disorders of iron metabolism, and a more comprehensive understanding of the mechanism of iron metabolism in the course of physical exercises could expand ways of treatment and prevention of sports anemia. In recent years, there have been remarkable research advances regarding the molecular mechanisms underlying changes of iron metabolism in response to physical exercises. This review has covered these advances, including effects of exercise on duodenum iron absorption, serum iron status, iron distribution in organs, erythropoiesis, and hepcidin's function and its regulation. New methods for the treatment of exercise-induced iron deficiency are also discussed.
authors.affiliation: Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang 050016, Hebei Province, P. R. China ; Bioreactor and Protein Drug Research and Development Center of Hebei Universities, Hebei Chemical & Pharmaceutical College, Shijiazhuang 050026, Hebei Province, P. R. China.
authors.forename: Wei-Na
authors.initials: WN
authors.lastname: Kong
authors.affiliation: Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang 050016, Hebei Province, P. R. China.
authors.forename: Guofen
authors.initials: G
authors.lastname: Gao
authors.affiliation: Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang 050016, Hebei Province, P. R. China.
authors.forename: Yan-Zhong
authors.initials: YZ
authors.lastname: Chang
keywords: Anemia; Exercise; Hepcidin; Iron metabolism
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