title: Protein PYY and its role in metabolism.
abstract: The hormone PYY is released from the distal gut in response to nutrient ingestion. Numerous studies have shown that PYY3-36, the most abundant circulating isoform of PYY, reduces food intake when given to obese rodents and humans. Its infusion to mimic postprandial levels in fasting subjects inhibits appetite, suggesting a physiological role in postprandial satiety. However, the mechanisms underlying this effect remain unclear. Neuronal activity within several brain areas appears to be modified following peripheral administration of PYY3-36 and a direct effect on the central nervous system is possible. Several studies suggest that PYY3-36 levels are reduced in obesity and are elevated following gastric bypass surgery, possibly contributing to the increased feelings of satiety following this procedure. Whether PYY has a role in the regulation of energy expenditure is currently unclear. However, due to the clear appetite-inhibitory effect of PYY, this hormone continues to be investigated as a potential therapeutic agent in the treatment of obesity.
authors.affiliation: Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
authors.forename: Samantha L
authors.initials: SL
authors.lastname: Price
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Bloom
mesh_terms: D000818:Animals; D001069:Appetite Regulation / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D002149:Energy Intake / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D009765:Obesity / Q000378:metabolism; D019894:Peptide YY / Q000378:metabolism*; D012527:Satiation / Q000502:physiology*
chemical_list: D019894:Peptide YY