title: Plasmid carriage of bla NDM-1 in clinical Acinetobacter baumannii isolates from India.
abstract: NDM-1 probably emerged in Acinetobacter species prior to its dissemination among Enterobacteriaceae, and NDM-1-like enzymes are increasingly reported in Acinetobacter species. Here, we report on the genetic context of blaNDM-1 in the earliest known NDM-1-producing organisms, clinical isolates of Acinetobacter from India in 2005. These strains harbor blaNDM-1 plasmids of different sizes. The gene is associated with the remnants of the Tn125 transposon normally associated with blaNDM-1 in Acinetobacter spp. The transposon has been disrupted by the IS26 insertion and subsequent movement events.
authors.affiliation: Cardiff University, Cardiff School of Medicine, University Hospital of Wales, Heath Park, Cardiff, United Kingdom Public Health Wales Microbiology Cardiff, University Hospital of Wales, Heath Park, Cardiff, United Kingdom jonesls5@cardiff.ac.uk.
authors.forename: Lim S
authors.initials: LS
authors.lastname: Jones
authors.affiliation: Cardiff University, Cardiff School of Medicine, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Toleman
authors.affiliation: Cardiff University, Cardiff School of Medicine, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
authors.forename: Janis L
authors.initials: JL
authors.lastname: Weeks
authors.affiliation: Cardiff University, Cardiff School of Medicine, University Hospital of Wales, Heath Park, Cardiff, United Kingdom Public Health Wales Microbiology Cardiff, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
authors.forename: Robin A
authors.initials: RA
authors.lastname: Howe
authors.affiliation: Cardiff University, Cardiff School of Medicine, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Walsh
authors.affiliation: Department of Microbiology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India.
authors.forename: Karthikeyan K
authors.initials: KK
authors.lastname: Kumarasamy
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004251:DNA Transposable Elements / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D006801:Humans; D007194:India; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D010957:Plasmids / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1
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