title: The importance of systemic therapy in minimizing local recurrence after breast-conserving surgery: the NSABP experience.
abstract: Adjuvant systemic therapy significantly reduces rates of distant recurrence and death. The effect of systemic therapy is not limited to reducing distant recurrences but also extends to reducing loco-regional recurrences, and rates of loco-regional recurrence have steadily declined over the past 25 years. This review focuses on the effect of adjuvant systemic therapy on rates of ipsilateral breast tumor recurrence following lumpectomy plus breast irradiation in several pivotal NSABP trials in early-stage breast cancer.
authors.affiliation: UF Health Cancer Center at Orlando Health, Orlando, Florida.
authors.forename: Eleftherios P
authors.initials: EP
authors.lastname: Mamounas
authors.forename: Gong
authors.initials: G
authors.lastname: Tang
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
mesh_terms: D001943:Breast Neoplasms / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*
keywords: adjuvant systemic therapy; ipsilateral breast tumor recurrence; lumpectomy
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