title: Aptamer-targeted DNA nanostructures for therapeutic delivery.
abstract: DNA-based nanostructures have been widely used in various applications due to their structural diversity, programmability, and uniform structures. Their intrinsic biocompatibility and biodegradability further motivates the investigation of DNA-based nanostructures as delivery vehicles. Incorporating AS1411 aptamers into DNA pyramids leads to enhanced intracellular uptake and selectively inhibits the growth of cancer cells, achieved without the use of transfection reagents. Furthermore, aptamer-displaying pyramids are found to be substantially more resistant to nuclease degradation than single-stranded aptamers. These findings, along with their modularity, reinforce the potential of DNA-based nanostructures for therapeutic applications.
authors.affiliation: Department of Polymer Science and Engineering, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors.forename: Phapanin
authors.initials: P
authors.lastname: Charoenphol
authors.forename: Harry
authors.initials: H
authors.lastname: Bermudez
mesh_terms: D052157:Aptamers, Nucleotide; D004247:DNA / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D050997:Nanomedicine; D049329:Nanostructures / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*
chemical_list: C513936:AGRO 100; D052157:Aptamers, Nucleotide; D004337:Drug Carriers; D009838:Oligodeoxyribonucleotides; D004247:DNA
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