title: TRPV2.
abstract: Transient receptor potential vanilloid type 2, TRPV2, is a calcium-permeable cation channel belonging to the TRPV channel family. This channel is activated by heat (>52 °C), various ligands, and mechanical stresses. In most of the cells, a large portion of TRPV2 is located in the endoplasmic reticulum under unstimulated conditions. Upon stimulation of the cells with phosphatidylinositol 3-kinase-activating ligands, TRPV2 is translocated to the plasma membrane and functions as a cation channel. Mechanical stress may also induce translocation of TRPV2 to the plasma membrane. The expression of TRPV2 is high in some types of cells including neurons, neuroendocrine cells, immune cells involved in innate immunity, and certain types of cancer cells. TRPV2 may modulate various cellular functions in these cells.
authors.affiliation: Department of Cell Biology, Institute for Molecular & Cellular Regulation, Gunma University, Maebashi, Gunma Prefecture, 371-8511, Japan, ikojima@gunma-u.ac.jp.
authors.forename: Itaru
authors.initials: I
authors.lastname: Kojima
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nagasawa
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D002463:Cell Membrane Permeability; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D015640:Ion Channel Gating; D008564:Membrane Potentials; D018345:Mice, Knockout; D010641:Phenotype; D015398:Signal Transduction; D050916:TRPV Cation Channels / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D050916:TRPV Cation Channels; C400769:TRPV2 protein, human; C485717:Trpv2 protein, mouse