title: Synthesis, characterization and anti-tubercular activity of ferrocenyl hydrazones and their β-cyclodextrin conjugates.
abstract: A series of ferrocenyl hydrazones and their β-cyclodextrin (CD) inclusion complexes were prepared and evaluated for antitubercular activity under low and high iron conditions. The inclusion complexes were characterized by Fourier Transform Infrared (FTIR), Differential Scanning Calorimetry (DSC), Powder X-ray Diffraction (PXRD), (1)H NMR, Scanning Electron Microscopy (SEM) and Cyclic Voltammetric (CV) studies. The inclusion complexes exhibited improved aqueous solubility as well as enhanced hydrolytic and thermal stability. They were also found to exhibit greater antitubercular activity than the parent ferrocenyl hydrazones against Mycobacterium tuberculosis under high iron conditions. When grown under low iron conditions these compounds exhibited lower activity suggesting requirement of iron-dependant peroxidase activation.
authors.affiliation: ISTRA, Department of Chemistry, Abeda Inamdar Senior College, University of Pune, 411001, India.
authors.forename: Prasad
authors.initials: P
authors.lastname: Dandawate
authors.affiliation: Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India.
authors.forename: Kiranmayi
authors.initials: K
authors.lastname: Vemuri
authors.affiliation: ISTRA, Department of Chemistry, Abeda Inamdar Senior College, University of Pune, 411001, India.
authors.forename: Ejazuddin M
authors.initials: EM
authors.lastname: Khan
authors.affiliation: Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India.
authors.forename: Manjula
authors.initials: M
authors.lastname: Sritharan
authors.affiliation: ISTRA, Department of Chemistry, Abeda Inamdar Senior College, University of Pune, 411001, India. Electronic address: sbpadhye@hotmail.com.
authors.forename: Subhash
authors.initials: S
authors.lastname: Padhye
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D006835:Hydrazones / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D006835:Hydrazones; D047392:beta-Cyclodextrins
keywords: Antitubercular activity; Ferrocenyl hydrazones; Inclusion complex; β-Cyclodextrin