title: Gamma power and cognition in patients with schizophrenia and their first-degree relatives.
abstract: BACKGROUND
  Gamma oscillations are essential for functional neural assembly formation underlying higher cerebral functions. Previous studies concerning gamma band power in schizophrenia have yielded diverse results.
  
  
  METHODS
  In this study, we assessed gamma band power in minimally treated patients with schizophrenia, their first-degree relatives and healthy controls during an oddball paradigm performance, as well as the relation between gamma power and cognitive performance.
  
  
  RESULTS
  We found a higher gamma power in the patient group than in the healthy controls at the P3, P4, Fz, Pz and T5 sites. Compared with their relatives, gamma power in the patients was only marginally higher over P3 and P4. We found a nearly significant inverse association between gamma power at F4 and Tower of London performance in the patients, as well as a significant inverse association between gamma power at T5 and verbal memory and working memory scores in the relatives.
  
  
  CONCLUSIONS
  These results support higher total gamma power in association with schizophrenia and its inverse association with cognitive performance in patients and their first-degree relatives.
authors.affiliation: Basic Psychology, Psychobiology and Methodology Department, School of Psychology, University of Salamanca, Salamanca, Spain.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Díez
authors.forename: Vanessa
authors.initials: V
authors.lastname: Suazo
authors.forename: Pilar
authors.initials: P
authors.lastname: Casado
authors.forename: Manuel
authors.initials: M
authors.lastname: Martín-Loeches
authors.forename: Vicente
authors.initials: V
authors.lastname: Molina
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D005190:Family; D005260:Female; D065818:Gamma Rhythm / Q000187:drug effects; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008568:Memory; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013067:Speech Perception; D013647:Task Performance and Analysis
chemical_list: D014150:Antipsychotic Agents; D006220:Haloperidol