title: Inflammation and infections in asthma.
abstract: BACKGROUND
  Asthma is driven by an inflammatory response against normally harmless environmental inorganic and organic compounds in the respiratory tract. Immune responses to airborne pathogens such as viruses and bacteria may reduce the allergic responses but are also known to trigger asthma attacks and eventually lead to severe disease condition.
  
  
  OBJECTIVE
  To investigate the role of respiratory pathogens concerning the induction or protection against acute or chronic asthma manifestations.
  
  
  METHODS
  We included 131 articles for the final review according to their relevance with the subject.
  
  
  RESULTS
  There is apparently contradictory interaction of respiratory germs in the airways of asthmatics which may be protective on one angle but deleterious on the other.
  
  
  CONCLUSIONS
  The relationship between inflammation and remodeling and the pathogenic role of viral and bacterial infection in the airways of asthmatic patients is still highly debatable and incompletely understood.
authors.affiliation: Department of Pulmonary Medicine, General Hospital Kassel, Kassel, Germany.
authors.forename: Adrian
authors.initials: A
authors.lastname: Gillissen
authors.affiliation: Department of Pulmonary Medicine, General Hospital Kassel, Kassel, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Paparoupa
mesh_terms: D056151:Airway Remodeling / Q000502:physiology; D001249:Asthma / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D012141:Respiratory Tract Infections / Q000150:complications / Q000473:pathology
keywords: asthma; asthma control; bacteria; infection; virus
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