title: Next-generation genomic profiling of hepatocellular adenomas: a new era of individualized patient care.
abstract: Hepatocellular adenomas (HCAs) are clinically relevant benign liver lesions that commonly occur in women on hormonal contraceptives. In this issue of Cancer Cell, Pilati and colleagues present an integrative multi-"omics"-based analysis of HCA and identify recurrent genetic alterations associated with adenoma-carcinoma transition and new drugable targets.
authors.affiliation: Laboratory of Experimental Carcinogenesis (LEC), Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Drive, Room 4146, Bethesda, MD 20892, USA; Department of Medicine I, Johannes Gutenberg University, 55131 Mainz, Germany. Electronic address: marquarj@uni-mainz.de.
authors.forename: Jens U
authors.initials: JU
authors.lastname: Marquardt
authors.affiliation: Laboratory of Experimental Carcinogenesis (LEC), Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Drive, Room 4146, Bethesda, MD 20892, USA. Electronic address: snorri_thorgeirsson@nih.gov.
authors.forename: Snorri S
authors.initials: SS
authors.lastname: Thorgeirsson
mesh_terms: D018248:Adenoma, Liver Cell / Q000235:genetics*; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: D009363:Neoplasm Proteins; D011505:Protein-Tyrosine Kinases; C092830:FRK protein, human
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