title: MicroRNAs-role in lung cancer.
abstract: Regulation of gene expression is essential for normal physiological functions; thus deregulation of gene expression is common in disease conditions. One level of regulation of gene expression is performed by noncoding RNAs, among which microRNAs (miRNA) are the best studied. Abnormal expression of these molecular players can lead to pathogenic processes such as heart disease, immune system abnormalities, and carcinogenesis, to name but a few. Of a length of 18-25 nucleotides miRNAs are involved in binding partial complementary sequences within the 3'-UTR (3'-untranslated region) of the target mRNAs. Depending on the type of neoplastic transformation, miRNAs can act both as oncogenes (oncomirs) or as tumor suppressors. Because of the great importance of miRNAs, most researches focus on either their role as biomarkers or their potential as therapeutic targets. Herein, we present the review of microRNA biology, function, and tumorigenic potential with emphasis on their role in lung cancer.
authors.affiliation: Chair and Department of Biochemistry and Molecular Biology, Medical University of Lublin, Ulica Witolda Chodźki 1, 20-093 Lublin, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Guz
authors.affiliation: Department of Physiology, Institute of Biomedicine, University of Turku, 20520 Turku, Finland.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Rivero-Müller
authors.affiliation: Chair and Department of Biochemistry and Molecular Biology, Medical University of Lublin, Ulica Witolda Chodźki 1, 20-093 Lublin, Poland.
authors.forename: Estera
authors.initials: E
authors.lastname: Okoń
authors.affiliation: Chair and Department of Biochemistry and Molecular Biology, Medical University of Lublin, Ulica Witolda Chodźki 1, 20-093 Lublin, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Stenzel-Bembenek
authors.affiliation: Department of Otolaryngology, MSW Hospital, 20-331 Lublin, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Polberg
authors.affiliation: Chair and Department of Gastroenterology with Endoscopic Unit, Medical University of Lublin, 20-093 Lublin, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Słomka
authors.affiliation: Chair and Department of Biochemistry and Molecular Biology, Medical University of Lublin, Ulica Witolda Chodźki 1, 20-093 Lublin, Poland ; Department of Otolaryngology, MSW Hospital, 20-331 Lublin, Poland.
authors.forename: Andrzej
authors.identifier: 0000-0002-1872-394X
authors.initials: A
authors.lastname: Stepulak
mesh_terms: D042501:Angiogenic Proteins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D014408:Biomarkers, Tumor / Q000502:physiology*; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference
chemical_list: D042501:Angiogenic Proteins; D014408:Biomarkers, Tumor; D035683:MicroRNAs
references.citation: Cell. 2003 Apr 4;113(1):25-36
references.pmid: 12679032
references.citation: Cell Death Differ. 2012 Jun;19(6):1038-48
references.pmid: 22193543
references.citation: Lung Cancer. 2006 Feb;51(2):143-58
references.pmid: 16360975
references.citation: Nat Med. 2011 Dec 11;18(1):74-82
references.pmid: 22157681
references.citation: Int J Oncol. 2011 Apr;38(4):1013-22
references.pmid: 21271217
references.citation: Nat Cell Biol. 2008 Dec;10(12):1470-6
references.pmid: 19011622
references.citation: Cancer Res. 2009 Jul 1;69(13):5553-9
references.pmid: 19549910
references.citation: Cell Death Dis. 2013 Mar 14;4:e544
references.pmid: 23492775
references.citation: Biomed Pharmacother. 2011 Sep;65(6):436-42
references.pmid: 21880462
references.citation: J Biol Chem. 2008 Nov 28;283(48):33394-405
references.pmid: 18818206
references.citation: Clin Cancer Res. 2011 Sep 15;17(18):5867-77
references.pmid: 21807633
references.citation: Nat Med. 2011 Feb;17(2):211-5
references.pmid: 21240262
references.citation: Cancer Sci. 2010 Oct;101(10):2087-92
references.pmid: 20624164
references.citation: Cell. 1997 Aug 8;90(3):405-13
references.pmid: 9267021
references.citation: Chromosome Res. 2008;16(2):243-60
references.pmid: 18204908
references.citation: Curr Top Microbiol Immunol. 1998;227:25-41
references.pmid: 9479824
references.citation: Cancer Biother Radiopharm. 2013 Feb;28(1):45-50
references.pmid: 23036084
references.citation: Cell Cycle. 2013 Dec 15;12(24):3781-90
references.pmid: 24107628
references.citation: Cancer Res. 2005 Aug 15;65(16):7065-70
references.pmid: 16103053
references.citation: Mol Cancer. 2009 Nov 14;8:102
references.pmid: 19912656
references.citation: Oncol Lett. 2013 Aug;6(2):359-366
references.pmid: 24137330
references.citation: Cancer Chemother Pharmacol. 2012 Mar;69(3):723-31
references.pmid: 21993663
references.citation: FEBS Lett. 2009 Nov 3;583(21):3501-7
references.pmid: 19818775
references.citation: Genome Res. 2009 Jan;19(1):92-105
references.pmid: 18955434
references.citation: Dev Biol. 2007 Feb 1;302(1):1-12
references.pmid: 16989803
references.citation: Cell. 1994 Nov 18;79(4):563-71
references.pmid: 7954823
references.citation: Int J Oncol. 2013 Mar;42(3):957-62
references.pmid: 23314612
references.citation: J Biol Chem. 1992 Dec 25;267(36):26031-7
references.pmid: 1464614
references.citation: Genes Chromosomes Cancer. 2013 Oct;52(10):895-911
references.pmid: 23929716
references.citation: Nat Struct Mol Biol. 2009 Jan;16(1):23-9
references.pmid: 19079265
references.citation: FEBS Lett. 2008 Apr 30;582(10):1564-8
references.pmid: 18406353
references.citation: Nature. 2000 Feb 24;403(6772):901-6
references.pmid: 10706289
references.citation: Nat Immunol. 2006 Aug;7(8):819-26
references.pmid: 16819554
references.citation: Nucleic Acids Res. 2008 Nov;36(20):6439-49
references.pmid: 18842624
references.citation: RNA Biol. 2013 Feb;10(2):287-300
references.pmid: 23353574
references.citation: Nature. 2004 Nov 11;432(7014):231-5
references.pmid: 15531879
references.citation: PLoS One. 2013 Jun 21;8(6):e67581
references.pmid: 23805317
references.citation: Oncol Rep. 2012 Jan;27(1):129-34
references.pmid: 21935578
references.citation: Antioxid Redox Signal. 2013 Sep 1;19(7):644-60
references.pmid: 23617628
references.citation: Biochim Biophys Acta. 2012 Nov;1822(11):1692-704
references.pmid: 22885155
references.citation: Biomed Pharmacother. 2010 Jul;64(6):399-408
references.pmid: 20363096
references.citation: Genes Dev. 1995 May 15;9(10):1149-63
references.pmid: 7758941
references.citation: FEBS Lett. 2013 Aug 2;587(15):2346-51
references.pmid: 23747308
references.citation: Cancer Metastasis Rev. 2007 Jun;26(2):281-90
references.pmid: 17603752
references.citation: Cancer Cell. 2006 Mar;9(3):189-98
references.pmid: 16530703
references.citation: Cell. 1997 Nov 14;91(4):479-89
references.pmid: 9390557
references.citation: Int J Oncol. 2010 Dec;37(6):1621-6
references.pmid: 21042732
references.citation: J Pathol. 2011 Jan;223(2):102-15
references.pmid: 21125669
references.citation: Nat Genet. 2007 May;39(5):673-7
references.pmid: 17401365
references.citation: PLoS One. 2013 Oct 09;8(10):e78649
references.pmid: 24130905
references.citation: Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16230-5
references.pmid: 18852463
references.citation: FEBS Lett. 2013 Jan 4;587(1):73-81
references.pmid: 23178712
references.citation: PLoS One. 2011;6(6):e21300
references.pmid: 21731696
references.citation: Cancer Res. 2007 Sep 15;67(18):8699-707
references.pmid: 17875710
references.citation: Oncogene. 2013 Jun 20;32(25):3071-9
references.pmid: 22824797
references.citation: Mol Cancer Res. 2011 Jan;9(1):25-35
references.pmid: 21115742
references.citation: Curr Top Microbiol Immunol. 1998;227:43-55
references.pmid: 9479825
references.citation: Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2595-606
references.pmid: 21885851
references.citation: Science. 2007 Jan 5;315(5808):97-100
references.pmid: 17204650
references.citation: Nat Rev Cancer. 2006 Apr;6(4):259-69
references.pmid: 16557279
references.citation: Cancer Res. 2011 May 15;71(10):3658-68
references.pmid: 21444672
references.citation: Oncol Rep. 2010 Nov;24(5):1217-23
references.pmid: 20878113
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61
references.pmid: 16461460
references.citation: Cancer Res. 2004 Jun 1;64(11):3753-6
references.pmid: 15172979
references.citation: Lung Cancer. 2007 Dec;58(3):392-6
references.pmid: 17728006
references.citation: Cancer Res. 2013 Jan 15;73(2):756-66
references.pmid: 23204228
references.citation: Nature. 2004 Nov 11;432(7014):226-30
references.pmid: 15538371
references.citation: Cell. 1993 Dec 3;75(5):843-54
references.pmid: 8252621
references.citation: RNA Biol. 2012 Jun;9(6):900-10
references.pmid: 22664918
references.citation: Genome Res. 2004 Oct;14(10A):1902-10
references.pmid: 15364901
references.citation: Cell. 1993 Dec 3;75(5):855-62
references.pmid: 8252622
references.citation: N Engl J Med. 2005 Oct 27;353(17):1793-801
references.pmid: 16251535
references.citation: Mol Cell Biol. 1995 May;15(5):2612-24
references.pmid: 7739542
references.citation: Mol Oncol. 2011 Jun;5(3):281-91
references.pmid: 21398193
references.citation: Cell Death Differ. 2011 Mar;18(3):465-78
references.pmid: 20885442
references.citation: Anticancer Res. 2012 May;32(5):1603-9
references.pmid: 22593438
references.citation: Mol Cancer Res. 2013 Jul;11(7):699-713
references.pmid: 23562878
references.citation: Cytokine Growth Factor Rev. 2005 Apr;16(2):159-78
references.pmid: 15863032
references.citation: Cancer Res. 2008 Jul 15;68(14):5540-5
references.pmid: 18632605
references.citation: Tumour Biol. 2013 Dec;34(6):4017-26
references.pmid: 23857284
references.citation: Cancer Gene Ther. 2012 Nov;19(11):773-8
references.pmid: 22996741
references.citation: Exp Lung Res. 2011 Sep;37(7):387-98
references.pmid: 21777146
references.citation: Curr Pharm Biotechnol. 2009 Sep;10(6):569-78
references.pmid: 19619125
references.citation: Oncogene. 2005 Apr 18;24(17):2899-908
references.pmid: 15838523
references.citation: Cell Prolif. 2003 Jun;36(3):131-49
references.pmid: 12814430
references.citation: Cancer Res. 2012 Nov 1;72(21):5576-87
references.pmid: 22964582
references.citation: Nat Rev Cancer. 2010 Apr;10(4):232-3
references.pmid: 20355252
references.citation: Science. 2004 Jan 2;303(5654):83-6
references.pmid: 14657504
references.citation: Mol Cell Biochem. 2013 Nov;383(1-2):67-75
references.pmid: 23881177
references.citation: RNA Biol. 2013 Nov;10(11):1700-13
references.pmid: 24157646
references.citation: Clin Cancer Res. 2010 Jan 15;16(2):610-9
references.pmid: 20068099
references.citation: Cell. 1991 Dec 20;67(6):1169-79
references.pmid: 1836977
references.citation: Oncogene. 2013 Jan 17;32(3):341-51
references.pmid: 22370637
references.citation: J Cell Biol. 2001 Apr 16;153(2):319-28
references.pmid: 11309413
references.citation: Cancer Res. 2010 May 1;70(9):3638-46
references.pmid: 20388802
references.citation: J Immunol. 2009 Oct 1;183(7):4169-75
references.pmid: 19767566
references.citation: Int J Mol Med. 2013 Sep;32(3):593-8
references.pmid: 23856992
references.citation: EMBO J. 2012 Aug 29;31(17):3513-23
references.pmid: 22773185
references.citation: Oncol Rep. 2013 Feb;29(2):704-12
references.pmid: 23228962
references.citation: Oncogene. 2008 Jun 19;27(27):3845-55
references.pmid: 18246122
references.citation: Oncol Rep. 2013 Jul;30(1):492-8
references.pmid: 23670238
references.citation: Int J Mol Sci. 2012;13(2):1347-79
references.pmid: 22408395
references.citation: J Surg Oncol. 2011 Apr;103(5):411-5
references.pmid: 21400525
references.citation: Oncogene. 2006 Apr 20;25(17):2537-45
references.pmid: 16331254
references.citation: Dev Cell. 2011 Jul 19;21(1):92-101
references.pmid: 21763611
references.citation: Front Biosci. 2005 Jan 01;10:853-65
references.pmid: 15569594
references.citation: Cancer Res. 2010 Mar 1;70(5):1793-803
references.pmid: 20145152
references.citation: PLoS One. 2010 May 14;5(5):e10563
references.pmid: 20498841
references.citation: Nature. 2008 Sep 4;455(7209):58-63
references.pmid: 18668040
references.citation: Med Oncol. 2012 Mar;29(1):384-91
references.pmid: 21258880
references.citation: Cancer. 2011 Jul 15;117(14):3193-200
references.pmid: 21264844
references.citation: Pathol Res Pract. 2010 Aug 15;206(8):578-84
references.pmid: 20418022
references.citation: J Clin Invest. 2010 Apr;120(4):1298-309
references.pmid: 20237410
references.citation: Acta Biochim Biophys Sin (Shanghai). 2012 Jun;44(6):519-26
references.pmid: 22510476
references.citation: Cancer Cell. 2002 Feb;1(1):19-30
references.pmid: 12086884
references.citation: Nature. 2005 Jun 9;435(7043):834-8
references.pmid: 15944708
references.citation: Science. 2007 Apr 27;316(5824):575-9
references.pmid: 17379774
references.citation: Oncogene. 2014 Mar 20;33(12):1506-14
references.pmid: 23584484
references.citation: EMBO J. 2004 Oct 13;23(20):4051-60
references.pmid: 15372072
references.citation: Clin Cancer Res. 2009 Feb 15;15(4):1177-83
references.pmid: 19228723
references.citation: Cancer Res. 2007 Mar 15;67(6):2456-68
references.pmid: 17363563
references.citation: Cancer Res. 2013 Mar 15;73(6):1867-75
references.pmid: 23378343
references.citation: Nucleic Acids Res. 2011 Aug;39(15):6669-78
references.pmid: 21511813
references.citation: PLoS One. 2013 Oct 30;8(10):e78344
references.pmid: 24205206
references.citation: Nature. 1991 Nov 28;354(6351):314-7
references.pmid: 1659666
references.citation: Cancer Cell. 2004 May;5(5):429-41
references.pmid: 15144951
references.citation: Clin Chem. 2008 Oct;54(10):1696-704
references.pmid: 18719201
references.citation: Nature. 2000 Jan 6;403(6765):98-103
references.pmid: 10638761
references.citation: Clin Lung Cancer. 2009 Jan;10(1):42-6
references.pmid: 19289371
references.citation: Oncogene. 2003 Jul 10;22(28):4398-405
references.pmid: 12853976
references.citation: Curr Cancer Drug Targets. 2009 Aug;9(5):639-51
references.pmid: 19508171
references.citation: Carcinogenesis. 2012 May;33(5):1046-54
references.pmid: 22331473
references.citation: Cancer Res. 2000 Jan 15;60(2):203-12
references.pmid: 10667560
references.citation: JAMA. 2008 Jan 30;299(4):425-36
references.pmid: 18230780
references.citation: Cell Cycle. 2010 May;9(9):1809-18
references.pmid: 20404570
references.citation: Cell. 2000 Jan 7;100(1):57-70
references.pmid: 10647931
references.citation: Cell. 1994 Nov 18;79(4):551-5
references.pmid: 7954821
references.citation: Med Oncol. 2012 Dec;29(5):3190-7
references.pmid: 22782668
references.citation: Mol Cell. 2009 Sep 24;35(6):856-67
references.pmid: 19782034
references.citation: Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16570-5
references.pmid: 23012423
references.citation: J Thorac Oncol. 2011 Mar;6(3):482-8
references.pmid: 21258252
references.citation: Genes Dev. 2004 Dec 15;18(24):3016-27
references.pmid: 15574589
references.citation: Cell. 2001 Feb 23;104(4):487-501
references.pmid: 11239407
references.citation: Cancer Res. 2010 Apr 1;70(7):2675-85
references.pmid: 20233879
references.citation: Int J Cancer. 2010 Dec 15;127(12):2870-8
references.pmid: 21351266
references.citation: Nat Rev Genet. 2009 Oct;10(10):704-14
references.pmid: 19763153
references.citation: Int J Biochem Cell Biol. 1997 Apr;29(4):559-73
references.pmid: 9363633
references.citation: Cancer Biol Ther. 2011 Nov 15;12(10):908-14
references.pmid: 22027557
references.citation: Cancer Biol Ther. 2010 Apr 1;9(7):554-61
references.pmid: 20150764
references.citation: Oncogene. 2007 Nov 29;26(54):7508-16
references.pmid: 17563752
references.citation: Nature. 2007 Jun 28;447(7148):1130-4
references.pmid: 17554337
references.citation: Acta Biochim Biophys Sin (Shanghai). 2012 May;44(5):424-30
references.pmid: 22491710
references.citation: Mod Pathol. 2010 Aug;23(8):1157-64
references.pmid: 20526284
references.citation: RNA. 2009 Sep;15(9):1705-15
references.pmid: 19628621
references.citation: Pflugers Arch. 2011 Mar;461(3):307-15
references.pmid: 21207057
references.citation: Cancer Res. 2001 Mar 15;61(6):2413-9
references.pmid: 11289107
references.citation: Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8
references.pmid: 18663219
references.citation: RNA. 2011 Apr;17(4):675-86
references.pmid: 21363885
references.citation: J Thorac Oncol. 2012 Jul;7(7):1069-77
references.pmid: 22592211
references.citation: Cancer Res. 2010 Nov 1;70(21):8288-98
references.pmid: 20978195
references.citation: PLoS One. 2012;7(1):e29671
references.pmid: 22295063
references.citation: Oncogene. 2012 Feb 2;31(5):634-42
references.pmid: 21706050
references.citation: Nat Cell Biol. 2009 Mar;11(3):228-34
references.pmid: 19255566
references.citation: Nat Rev Cancer. 2006 Nov;6(11):857-66
references.pmid: 17060945
references.citation: Nat Commun. 2013;4:2427
references.pmid: 24018975
references.citation: J Interferon Cytokine Res. 2002 Nov;22(11):1129-35
references.pmid: 12513912
references.citation: Int J Cancer. 2010 Dec 1;127(11):2520-9
references.pmid: 20162574
references.citation: J Cell Biol. 1998 Jun 29;141(7):1659-73
references.pmid: 9647657
references.citation: Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15043-8
references.pmid: 23980150
references.citation: Cancer Res. 2010 Jul 15;70(14):5923-30
references.pmid: 20570894
references.citation: CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66
references.pmid: 17237035
references.citation: PLoS One. 2012;7(9):e45577
references.pmid: 23029111
references.citation: Br J Cancer. 2010 Oct 12;103(8):1144-8
references.pmid: 20859290
references.citation: Mol Biol Cell. 1993 Apr;4(4):397-411
references.pmid: 8389619
references.citation: Curr Genomics. 2010 Nov;11(7):513-8
references.pmid: 21532835
references.citation: Nucleic Acids Res. 2005 Sep 28;33(17):5394-403
references.pmid: 16192569
references.citation: J Thorac Oncol. 2011 Apr;6(4):671-8
references.pmid: 21270667