title: The BDNF Val66Met polymorphism does not moderate the effect of self-reported physical activity on depressive symptoms in midlife.
abstract: The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism may be associated with clinical and subsyndromal depression, but physical activity improves mood and increases BDNF expression. The aim of the study was to examine whether the BDNF polymorphism moderates an effect of physical activity on depressive symptoms. BDNF genotype, physical activity measured by the Paffenbarger Questionnaire, and depressive symptoms using the Center for Epidemiology Depression Scale (CES-D) were collected on 1072 participants (mean age=44). Multiple linear regression was used to examine the association between BDNF genotype, physical activity, and depressive symptoms. After adjusting for family income, age, and education, depressive symptoms were higher in Met carriers compared to Val homozygotes (p=0.03), but this was only significant in men. Physical activity was associated with fewer depressive symptoms, but only in women (p=0.01). BDNF genotype did not moderate the effect of physical activity on depressive symptoms (p=0.94). In midlife, the BDNF Val66Met polymorphism neither attenuates nor magnifies the effect of physical activity on depressive symptoms.
authors.affiliation: Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Swathi
authors.initials: S
authors.lastname: Gujral
authors.affiliation: Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Manuck
authors.affiliation: Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Ferrell
authors.affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Janine D
authors.initials: JD
authors.lastname: Flory
authors.affiliation: Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: kiericks@pitt.edu.
authors.forename: Kirk I
authors.initials: KI
authors.lastname: Erickson
mesh_terms: D000328:Adult; D000339:Affect; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003863:Depression / Q000235:genetics* / Q000523:psychology; D015444:Exercise / Q000502:physiology / Q000523:psychology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D057566:Self Report; D011795:Surveys and Questionnaires
chemical_list: D019208:Brain-Derived Neurotrophic Factor
keywords: BDNF polymorphism; Depression; Exercise
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