title: [Role of atrial structural and functional changes in the development and progression of atrial fibrillation].
abstract: Atrial fibrillation (AF) is one of the most common reasons for decreased life quality and increased mortality rates. Experimental and clinical data show that atrial structural and functional changes contribute to the development and progression of AF. The survey article considers the role of the systemic and local activities of the renin-angiotensin-aldosterone system and inflammatory mediators in the development of atrial structural remodeling, which may be a cause and a consequence of AF.
authors.forename: O P
authors.initials: OP
authors.lastname: Aparina
authors.forename: L N
authors.initials: LN
authors.lastname: Chikhireva
authors.forename: N A
authors.initials: NA
authors.lastname: Mironova
authors.forename: E S
authors.initials: ES
authors.lastname: Mironova
authors.forename: S A
authors.initials: SA
authors.lastname: Bakalov
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000503:physiopathology*; D016275:Atrial Function / Q000502:physiology*; D018450:Disease Progression; D006325:Heart Atria / Q000503:physiopathology*; D006801:Humans