title: Investigation of cerebral autoregulation in the newborn piglet during anaesthesia and surgery.
abstract: The relationship between cerebral autoregulation (CA) and the neurotoxic effects of anaesthesia with and without surgery is investigated. Newborn piglets were randomly assigned to receive either 6 h of anaesthesia (isoflurane) or the same with an additional hour of minor surgery. The effect of the spontaneous changes in mean arterial blood pressure (MABP) on the cerebral haemodynamics (oxy- and deoxy-haemoglobin, HbO2 and Hb) was measured using transverse broadband near-infrared spectroscopy (NIRS). A marker for impaired CA, concordance between MABP and intravascular oxygenation (HbD = HbO2 - Hb) in the ultra-low frequency domain (0.0018-0.0083 Hz), was assessed using coherence analysis. Presence of CA impairment was not significant but found to increase with surgical exacerbation. The impairment did not correlate with histological outcome (presence of cell death, apoptosis and microglial activation in the brain).
authors.affiliation: Biomedical Optics Research Laboratory, University College London, Malet Place Engineering Building, Gower St., London, WC1E6BT, UK. gemma.bale.11@ucl.ac.uk.
authors.forename: Gemma
authors.initials: G
authors.lastname: Bale
authors.affiliation: Institute for Women's Health, University College London, London, UK.
authors.forename: Aaron
authors.initials: A
authors.lastname: Oliver-Taylor
authors.affiliation: Institute for Women's Health, University College London, London, UK.
authors.forename: Igor
authors.initials: I
authors.lastname: Fierens
authors.affiliation: Institute for Women's Health, University College London, London, UK.
authors.forename: Kevin
authors.initials: K
authors.lastname: Broad
authors.affiliation: Institute for Women's Health, University College London, London, UK.
authors.forename: Jane
authors.initials: J
authors.lastname: Hassell
authors.affiliation: Institute for Women's Health, University College London, London, UK.
authors.forename: Go
authors.initials: G
authors.lastname: Kawano
authors.affiliation: Institute for Women's Health, University College London, London, UK.
authors.forename: Jamshid
authors.initials: J
authors.lastname: Rostami
authors.affiliation: Institute for Women's Health, University College London, London, UK.
authors.forename: Gennadij
authors.initials: G
authors.lastname: Raivich
authors.affiliation: Wellcome Centre for Imaging Neuroscience, University College London, London, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Sanders
authors.affiliation: Institute for Women's Health, University College London, London, UK.
authors.forename: Nicola
authors.initials: N
authors.lastname: Robertson
authors.affiliation: Biomedical Optics Research Laboratory, University College London, Malet Place Engineering Building, Gower St., London, WC1E6BT, UK.
authors.forename: Ilias
authors.initials: I
authors.lastname: Tachtsidis
mesh_terms: D000758:Anesthesia; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D019265:Spectroscopy, Near-Infrared; D013514:Surgical Procedures, Operative; D013552:Swine
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