title: [Treatment of acute full-thickness chondral defects with high molecular weight hyaluronic acid; an experimental model].
abstract: OBJECTIVE
  To evaluate the effect of 2 different protocols of intra-articular hyaluronic acid (HA, hylan G-F20) to articular cartilage regeneration in acute full-thickness chondral defects.
  
  
  METHODS
  Full-thickness chondral defects of 3 x 6 mm were performed into the lateral femoral condyles of New Zealand rabbits, treated with a single or three doses of HA. The animals were sacrified at 12 weeks and the regenerated tissue was evaluated by direct observation and histology with the ICRS scale. Macroscopically, in both groups treated with HA the defects were filled with irregular tissue with areas similar to hyaline cartilage and others in which depressed areas with exposed subchondral bone were observed. Histological analysis showed in both groups treated with HA a hyaline-like cartilage compared to control group. However, the score of the International Cartilage Repair Society (ICRS) scale did not show differences between the groups treated with HA.
  
  
  CONCLUSIONS
  The use of single dose or 3 doses of AH in acute chondral lesions has a limited and similar benefit in articular cartilage regeneration.
authors.affiliation: Departamento de Traumatología, Clínica Alemana de Santiago, Santiago, Chile.
authors.forename: D
authors.initials: D
authors.lastname: Figueroa
authors.affiliation: Facultad de Medicina Clínica Alemana-Universidad del Desarrollo, Santiago, Chile. Electronic address: maxespinosa@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Espinosa
authors.affiliation: Departamento de Traumatología, Clínica Alemana de Santiago, Santiago, Chile.
authors.forename: R
authors.initials: R
authors.lastname: Calvo
authors.affiliation: Departamento de Traumatología, Clínica Alemana de Santiago, Santiago, Chile.
authors.forename: M
authors.initials: M
authors.lastname: Scheu
authors.affiliation: Mutual de Seguridad, Santiago, Chile.
authors.forename: J J
authors.initials: JJ
authors.lastname: Valderrama
authors.affiliation: Departamento de Anatomía Patológica, Clínica Alemana de Santiago, Santiago, Chile.
authors.forename: M
authors.initials: M
authors.lastname: Gallegos
authors.affiliation: Facultad de Medicina Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.
authors.forename: P
authors.initials: P
authors.lastname: Conget
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000187:drug effects* / Q000502:physiology*; D004195:Disease Models, Animal; D006820:Hyaluronic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008970:Molecular Weight; D020370:Osteoarthritis, Knee / Q000628:therapy; D011817:Rabbits; D012038:Regeneration / Q000187:drug effects*; D055675:Viscosupplements / Q000627:therapeutic use*
chemical_list: D055675:Viscosupplements; C049816:hylan; D006820:Hyaluronic Acid
keywords: Artrosis; Cartilage; Cartílago hialino; High molecular weight hyaluronic acid; Osteoarthritis; Regeneración; Regeneration; Ácido hialurónico de alto peso molecular