title: Specificity of performance monitoring changes in obsessive-compulsive disorder.
abstract: Obsessive-compulsive disorder (OCD) is characterized by overactivity in frontal and striatal brain regions, and event-related potential studies have shown increased brain activity during performance monitoring. The error-related negativity (ERN) is a component of the event-related potential that is observed following incorrect responses, and signals the need for behavioral adjustments. ERN enhancements have even been considered as a biomarker or endophenotype of OCD. However over the past years, enhanced ERN amplitudes, although less reliably, were also found in anxiety and affective disorders. These results question the specificity of ERN alterations to OCD. The present review summarizes current findings on performance monitoring and feedback processing in OCD and their relation to behavioral measures. Further, it discusses possible differential mechanisms contributing to amplitude variations in different clinical conditions.
authors.affiliation: Otto-von-Guericke University, Institute of Psychology II, Magdeburg, Germany; Center for Behavioral Brain Sciences, Magdeburg, Germany. Electronic address: endrass@gmail.com.
authors.forename: Tanja
authors.initials: T
authors.lastname: Endrass
authors.affiliation: Otto-von-Guericke University, Institute of Psychology II, Magdeburg, Germany; Center for Behavioral Brain Sciences, Magdeburg, Germany; Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.
authors.forename: Markus
authors.initials: M
authors.lastname: Ullsperger
mesh_terms: D001008:Anxiety Disorders / Q000503:physiopathology* / Q000523:psychology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology* / Q000523:psychology
keywords: Biomarker; ERN; OCD; Performance monitoring; Specificity