title: The fetal patient -- ethical aspects of fetal therapy.
abstract: The pregnant patient is a vulnerable subject, and even more so when a serious fetal condition is diagnosed. (Invasive) fetal therapy should only be offered when there is a good chance that the life of the fetus will be saved, or irreversible damage by the disease or disability is prevented. Following diagnosis of a potentially treatable condition, the patient needs to be referred to a center with sufficient expertise in diagnosis and all therapeutic options. Preferences of the physician towards one or another antenatal intervention is not at stake prior to that moment. When fetal therapy is justified--, it should be offered with full respect for maternal choice and individual assessment and perception of potential-- risks, and should be at the location where there is sufficient expertise. For therapies of unproven benefit, the absence of evidence must be disclosed, and therapy should only be undertaken with full voluntary consent of the mother. These ought to be undertaken within well designed and approved trials and only by experts in the treatment modality. Potential risks and eventual morbidities in case of therapeutic failure should be part of the counselling, neither-- should fetal therapy be presented as an alternative to termination of pregnancy.
authors.affiliation: Department of Woman and Child, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium;
authors.forename: J
authors.initials: J
authors.lastname: Deprest
authors.affiliation: Department of Woman and Child, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium;
authors.forename: J
authors.initials: J
authors.lastname: Toelen
authors.affiliation: Division of Molecular Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium;
authors.forename: Z
authors.initials: Z
authors.lastname: Debyser
authors.affiliation: Department of Obstetrics and Gynaecology, University Medical Centre Groningen, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Rodrigues
authors.affiliation: Department of Woman and Child, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium;
authors.forename: R
authors.initials: R
authors.lastname: Devlieger
authors.affiliation: Department of Woman and Child, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium;
authors.forename: L
authors.initials: L
authors.lastname: De Catte
authors.affiliation: Department of Woman and Child, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium;
authors.forename: L
authors.initials: L
authors.lastname: Lewi
authors.affiliation: Department of Woman and Child, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium;
authors.forename: T
authors.initials: T
authors.lastname: Van Mieghem
authors.affiliation: Department of Woman and Child, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium;
authors.forename: G
authors.initials: G
authors.lastname: Naulaers
authors.affiliation: Department of Anesthesiology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium;
authors.forename: M
authors.initials: M
authors.lastname: Vandevelde
authors.affiliation: Department of Medical Imaging, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium;
authors.forename: F
authors.initials: F
authors.lastname: Claus
authors.affiliation: Centre for Bio-medical Ethics and Law, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium;
authors.forename: K
authors.initials: K
authors.lastname: Dierickx
keywords: Fetal therapy; fetal surgery; fetoscopy; informed consent; prenatal diagnosis; termination of ­pregnancy; trial
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