title: Histopathology of pineal germ cell tumors.
abstract: Germ cell tumors (GCTs) classically occur in gonads. However, they are the most frequent neoplasms in the pineal region. The pineal location of GCTs may be caused by the neoplastic transformation of a primordial germ cell that has mismigrated. The World Health Organization (WHO) recognizes 5 histological types of intracranial GCTs: germinoma and non-germinomatous tumors including embryonal carcinoma, yolk sac tumor, choriocarcinoma and mature or immature teratoma. Germinomas and teratomas are frequently encountered as pure tumors whereas the other types are mostly part of mixed GCTs. In this situation, the neuropathologist has to be able to identify each component of a GCT. When diagnosis is difficult, use of recent immunohistochemical markers such as OCT(octamer-binding transcription factor)3/4, Glypican 3, SALL(sal-like protein)4 may be required. OCT3/4 is helpful in the diagnosis of germinomas, Glypican 3 in the diagnosis of yolk sac tumors and SALL4 in the diagnosis of the germ cell nature of an intracranial tumor. When the germ cell nature of a pineal tumor is doubtful, the finding of an isochromosome 12p suggests the diagnosis of GCT. The final pathological report should always be confronted with the clinical data, especially the serum or cerebrospinal fluid levels of β-human chorionic gonadotropin (HCG) and alpha-fetoprotein.
authors.affiliation: Centre de pathologie et neuropathologie EST, groupement hospitalier EST, hospices civils de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France; Centre de recherche en neurosciences de Lyon, Inserm U1028, CNRS UMR5292, équipe neuro-oncologie et neuro-inflammation, Lyon, France. Electronic address: alexandre.vasiljevic@chu-lyon.fr.
authors.forename: A
authors.initials: A
authors.lastname: Vasiljevic
authors.affiliation: Service de neurochirurgie pédiatrique E, hôpital Pierre-Wertheimer, groupement hospitalier EST, hospices civils de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Szathmari
authors.affiliation: Centre de recherche en neurosciences de Lyon, Inserm U1028, CNRS UMR5292, équipe neuro-oncologie et neuro-inflammation, Lyon, France.
authors.forename: J
authors.initials: J
authors.lastname: Champier
authors.affiliation: Centre de recherche en neurosciences de Lyon, Inserm U1028, CNRS UMR5292, équipe neuro-oncologie et neuro-inflammation, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Fèvre-Montange
authors.affiliation: Centre de pathologie et neuropathologie EST, groupement hospitalier EST, hospices civils de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France; Centre de recherche en neurosciences de Lyon, Inserm U1028, CNRS UMR5292, équipe neuro-oncologie et neuro-inflammation, Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Jouvet
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology*; D053673:Glypicans / Q000378:metabolism; D006801:Humans; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis / Q000473:pathology*; D010870:Pineal Gland / Q000473:pathology*; D010871:Pinealoma / Q000175:diagnosis / Q000473:pathology*; D013724:Teratoma / Q000175:diagnosis / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; C105937:GPC3 protein, human; D053673:Glypicans
keywords: Anatomopathologie; Germ cell tumors; Glande pinéale; Histogenesis; Histogenèse; Pathology; Pineal gland; Tumeurs germinales