title: Determination of the influence of home delivery of HIV therapy on virological outcomes and adherence.
abstract: The aim of this study was to evaluate whether the change in the mode of supply of HIV medicines to a homecare model was associated with any change in adherence and patient outcomes. We conducted a retrospective analysis of medical records of 100 patients who received supplies from a clinic-based hospital HIV pharmacy and 100 patients who were started on home delivery over a three-month period and were followed up over six months. Data on patient demographics, type of HIV drug regimen, HIV viral load, CD4% and adherence status were analysed. The mode of delivery had no significant effect on CD4% (p > 0.05), HIV viral load status (p > 0.05) or adherence status (p > 0.05). There was a significant increase in CD4% over time for both groups (p < 0.01). This study suggests that expanding home delivery as a model of care in London HIV clinics is safe and does not affect adherence and patient outcomes as indicated by HIV viral load and CD4%.
authors.affiliation: Guy's and St. Thomas' NHS Foundation Trust, St. Thomas' Hospital, London, UK sheena.castelino@gstt.nhs.uk.
authors.forename: Sheena
authors.initials: S
authors.lastname: Castelino
authors.affiliation: King's College London, Institute of Pharmaceutical Sciences, London, UK.
authors.forename: Hamida
authors.initials: H
authors.lastname: Miah
authors.affiliation: King's College London, Institute of Pharmaceutical Sciences, London, UK.
authors.forename: Vivian
authors.initials: V
authors.lastname: Auyeung
authors.affiliation: King's College London, Institute of Pharmaceutical Sciences, London, UK.
authors.forename: Florian
authors.initials: F
authors.lastname: Vogt
mesh_terms: D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006699:Home Care Services; D006801:Humans; D008131:London; D008297:Male; D008875:Middle Aged; D010593:Pharmaceutical Services; D015397:Program Evaluation; D012189:Retrospective Studies; D016896:Treatment Outcome; D019562:Viral Load; D016903:Drug Monitoring
chemical_list: D019380:Anti-HIV Agents
keywords: AIDS; HIV; antiretroviral therapy; home care; pharmacy; supplies; treatment