title: [Effects on blood fat and bone density of postmenopausal women fed by soy protein with isoflavone].
abstract: OBJECTIVE
  To explore the effects of phytoestrogen (PE) on blood lipid and bone density in postmenopausal women.
  
  
  METHODS
  A total of 75 menopausal women aged 50-70 years with estrogen reduction symptoms received an intake of soy protein containing 70 mg isoflavone daily in a year. Their changes of blood fat, density lumbar bone and sex hormone level were compared with control group without an intake.
  
  
  RESULTS
  The changes of blood triglyceride (TG), total cholesterol (TC) and low-density lipoprotein (LDL) in two groups before and after a year showed no statistical significance.High-density lipoprotein (HDL) decreased in control group while it had no significant change in the study group. Bone densities in two groups showed a downward trend by an annual rate of 1%-4%, the changes in two groups showed no statistical significance.E2 increased slightly over basic value in the study group. But it had no statistical significance. The changes of follicle-stimulating hormone (FSH) in two groups were also similar.
  
  
  CONCLUSIONS
  The above soy protein preparation has no effect on hypothalamic-pituitary-ovarian axis and no stimulation on endometrium of uterus. But it may improve the profile of HDL.
authors.affiliation: International Peace Maternity & Child Health Hospital, Shanghai Jiaotong University, Shanghai 200030, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: International Peace Maternity & Child Health Hospital, Shanghai Jiaotong University, Shanghai 200030, China. Email: liuxa@sh163.net.
authors.forename: Xiaoai
authors.initials: X
authors.lastname: Liu
mesh_terms: D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008875:Middle Aged; D048789:Phytoestrogens / Q000494:pharmacology*; D017698:Postmenopause; D030262:Soybean Proteins / Q000494:pharmacology*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007529:Isoflavones; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D048789:Phytoestrogens; D030262:Soybean Proteins