title: Estimation of insulin sensitivity in children: methods, measures and controversies.
abstract: Insulin resistance is defined as a state where insulin produces a diminished biological response, primarily in its capacity as a glucose-regulating hormone. Insulin resistance is commonly diagnosed by pediatric clinicians, but is rarely measured directly in children or adolescents. This review provides an overview of the techniques that can be used to assess insulin sensitivity in children, summarizing the methods involved, the assumptions, pitfalls, and appropriate uses of each technique, as well as their validation and reproducibility in pediatric samples.
authors.affiliation: Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892-1103, USA.
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Brown
authors.forename: Jack A
authors.initials: JA
authors.lastname: Yanovski
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D015309:Glucose Clamp Technique; D006801:Humans; D007333:Insulin Resistance; D015596:Nutrition Assessment; D054928:Validation Studies as Topic
chemical_list: D015415:Biomarkers
keywords: FSIGT; HOMA; QUICKI; glucose clamp technique; glucose tolerance; insulin sensitivity; surrogate measures
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