title: Are urinary PAHs biomarkers of controlled exposure to diesel exhaust?
abstract: Urinary polycyclic aromatic hydrocarbons (PAHs) were evaluated as possible biomarkers of exposure to diesel exhaust (DE) in two controlled-chamber studies. We report levels of 14 PAHs from 28 subjects in urine that were collected before, immediately after and the morning after exposure. Using linear mixed-effects models, we tested for effects of DE exposure and several covariates (time, age, gender and urinary creatinine) on urinary PAH levels. DE exposures did not significantly alter urinary PAH levels. We conclude that urinary PAHs are not promising biomarkers of short-term exposures to DE in the range of 106-276 µg/m(3).
authors.affiliation: College of Natural Resources, University of California , Berkeley, CA , USA .
authors.forename: Sixin S
authors.initials: SS
authors.lastname: Lu
authors.forename: Jon R
authors.initials: JR
authors.lastname: Sobus
authors.forename: Gerd
authors.initials: G
authors.lastname: Sallsten
authors.forename: Maria
authors.initials: M
authors.lastname: Albin
authors.forename: Joachim D
authors.initials: JD
authors.lastname: Pleil
authors.forename: Anders
authors.initials: A
authors.lastname: Gudmundsson
authors.forename: Michael C
authors.initials: MC
authors.lastname: Madden
authors.forename: Bo
authors.initials: B
authors.lastname: Strandberg
authors.forename: Aneta
authors.initials: A
authors.lastname: Wierzbicka
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Rappaport
mesh_terms: D015415:Biomarkers / Q000652:urine*; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D011084:Polycyclic Aromatic Hydrocarbons / Q000652:urine*; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D011084:Polycyclic Aromatic Hydrocarbons; D001335:Vehicle Emissions; D003404:Creatinine
keywords: Biomarker; PAHs; diesel exhaust; polycyclic aromatic hydrocarbons; urine
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