title: [Regeneration of airway epithelium].
abstract: BACKGROUND
  Epithelial regeneration is a complex process. It can lead to the remodeling of the airway epithelium as in asthma, COPD or cystic fibrosis.
  
  
  BACKGROUND
  The development of in vivo and in vitro models has allowed the analysis of remodeling mechanisms and showed the role of components of extracellular matrix, proteases, cytokines and growth factors. Airway epithelial progenitors and stems cells have been studied in these models. However, their identification remains difficult.
  
  
  CONCLUSIONS
  Identification and characterization of airway epithelial progenitor/stem-cells, and a better knowledge of the regeneration process may allow the development of new therapeutic strategies for airway epithelial reconstitution.
authors.affiliation: Inserm UMRS 903, CHU de Reims, 45, rue Cognacq-Jay, 51092 Reims, France.
authors.forename: D
authors.initials: D
authors.lastname: Adam
authors.affiliation: Inserm UMRS 903, CHU de Reims, 45, rue Cognacq-Jay, 51092 Reims, France; Service des maladies respiratoires, CHU de Reims, 45, rue Cognacq-Jay, 51100 Reims, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Perotin
authors.affiliation: Service des maladies respiratoires, CHU de Reims, 45, rue Cognacq-Jay, 51100 Reims, France.
authors.forename: F
authors.initials: F
authors.lastname: Lebargy
authors.affiliation: Inserm UMRS 903, CHU de Reims, 45, rue Cognacq-Jay, 51092 Reims, France; Laboratoire d'histologie Pol Bouin, CHU de Reims, 45, rue Cognacq-Jay, 51092 Reims, France.
authors.forename: P
authors.initials: P
authors.lastname: Birembaut
authors.affiliation: Inserm UMRS 903, CHU de Reims, 45, rue Cognacq-Jay, 51092 Reims, France; Service des maladies respiratoires, CHU de Reims, 45, rue Cognacq-Jay, 51100 Reims, France. Electronic address: gdeslee@chu-reims.fr.
authors.forename: G
authors.initials: G
authors.lastname: Deslée
authors.affiliation: Inserm UMRS 903, CHU de Reims, 45, rue Cognacq-Jay, 51092 Reims, France.
authors.forename: C
authors.initials: C
authors.lastname: Coraux
mesh_terms: D056151:Airway Remodeling / Q000502:physiology*; D000818:Animals; D001249:Asthma / Q000503:physiopathology; D001980:Bronchi / Q000502:physiology*; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D002465:Cell Movement; D002478:Cells, Cultured; D002923:Cilia / Q000502:physiology; D003550:Cystic Fibrosis / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology; D004195:Disease Models, Animal; D053595:Embryonic Stem Cells / Q000166:cytology / Q000637:transplantation; D004847:Epithelial Cells / Q000378:metabolism; D004848:Epithelium / Q000502:physiology; D005109:Extracellular Matrix / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D008168:Lung / Q000502:physiology*; D020782:Matrix Metalloproteinases / Q000502:physiology; D008679:Metaplasia; D009079:Mucociliary Clearance; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology
chemical_list: D016207:Cytokines; D016326:Extracellular Matrix Proteins; D036341:Intercellular Signaling Peptides and Proteins; D020782:Matrix Metalloproteinases
keywords: Airway epithelium; BPCO; COPD; Cellules souches; Cystic fibrosis; Mucoviscidose; Regeneration; Régénération; Stem-cells; Épithélium des voies aériennes