title: Independent component analysis of instantaneous power-based fMRI.
abstract: In functional magnetic resonance imaging (fMRI) studies using spatial independent component analysis (sICA) method, a model of "latent variables" is often employed, which is based on the assumption that fMRI data are linear mixtures of statistically independent signals. However, actual fMRI signals are nonlinear and do not automatically meet with the requirement of sICA. To provide a better solution to this problem, we proposed a novel approach termed instantaneous power based fMRI (ip-fMRI) for regularization of fMRI data. Given that the instantaneous power of fMRI signals is a scalar value, it should be a linear mixture that naturally satisfies the "latent variables" model. Based on our simulated data, the curves of accuracy and resulting receiver-operating characteristic curves indicate that the proposed approach is superior to the traditional fMRI in terms of accuracy and specificity by using sICA. Experimental results from human subjects have shown that spatial components of a hand movement task-induced activation reveal a brain network more specific to motor function by ip-fMRI than that by the traditional fMRI. We conclude that ICA decomposition of ip-fMRI may be used to localize energy signal changes in the brain and may have a potential to be applied to detection of brain activity.
authors.affiliation: School of Psychology, Nanjing Normal University, Nanjing 210097, China ; Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Yuan
authors.identifier: 0000-0001-6295-7711
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Gang
authors.identifier: 0000-0003-2864-0395
authors.initials: G
authors.lastname: Zheng
authors.affiliation: Departments of Psychiatry and Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000502:physiology*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015233:Models, Statistical; D009068:Movement; D010100:Oxygen / Q000737:chemistry; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D062206:Spatial Analysis; D055815:Young Adult
chemical_list: D010100:Oxygen
references.citation: Hum Brain Mapp. 1998;6(5-6):368-72
references.pmid: 9788074
references.citation: Brain Topogr. 2009 Sep;22(2):134-44
references.pmid: 19408112
references.citation: Neuroimage. 2013 Oct 1;79:62-71
references.pmid: 23611864
references.citation: Hum Brain Mapp. 1998;6(3):160-88
references.pmid: 9673671
references.citation: Philos Trans A Math Phys Eng Sci. 2012 Dec 31;371(1984):20110534
references.pmid: 23277597
references.citation: Neural Netw. 2000 May-Jun;13(4-5):411-30
references.pmid: 10946390
references.citation: Hum Brain Mapp. 2002 Jul;16(3):146-57
references.pmid: 12112768
references.citation: Int J Neural Syst. 2004 Oct;14(5):267-92
references.pmid: 15593377
references.citation: Neuroimage. 2001 Oct;14(4):817-26
references.pmid: 11554800
references.citation: Neuropsychologia. 1971 Mar;9(1):97-113
references.pmid: 5146491
references.citation: J Comput Assist Tomogr. 1999 Mar-Apr;23(2):265-71
references.pmid: 10096335
references.citation: IEEE Trans Biomed Eng. 2009 Nov;56(11):2619-26
references.pmid: 19695993
references.citation: Neural Netw. 1999 Apr;12(3):429-439
references.pmid: 12662686
references.citation: Neuroimage. 2001 Nov;14(5):1080-8
references.pmid: 11697939
references.citation: Med Image Anal. 2007 Feb;11(1):1-20
references.pmid: 17097334
references.citation: Neuroimage. 2004 Jul;22(3):1214-22
references.pmid: 15219593
references.citation: Hum Brain Mapp. 2001 May;13(1):43-53
references.pmid: 11284046
references.citation: Biophys J. 1993 Mar;64(3):803-12
references.pmid: 8386018
references.citation: Neuroimage. 2003 Jun;19(2 Pt 1):253-60
references.pmid: 12814576
references.citation: Prilozi. 2007 Dec;28(2):127-36
references.pmid: 18356784
references.citation: Hum Brain Mapp. 2007 Nov;28(11):1251-66
references.pmid: 17274023