title: Acute retinal necrosis: clinical features, management and outcomes--a 10 year consecutive case series.
abstract: OBJECTIVE
  To determine the viral diagnosis and clinical outcome of eyes with acute retinal necrosis (ARN).
  
  
  METHODS
  A retrospective analysis was done of 62 eyes of 53 patients presenting to a tertiary care ophthalmic institute between 1997 and 2007 with features of ARN. All patients with active disease were started immediately on intravenous acyclovir followed by oral antivirals along with systemic steroids. A prophylactic laser retinopexy was performed in patients with a clear media to areas posterior to the necrotic retina.
  
  
  RESULTS
  The aqueous and the vitreous sample revealed herpes simplex virus in 19 (30.60%) and varicella zoster virus in 28 patients (45.16%). Forty-one (66.12%) eyes had retinal detachment. Prophylactic laser photocoagulation was given in 19 (30.64%) eyes. Surgical intervention was required in 32 (51.61%) eyes. Favorable functional outcome was seen in 28 (45.1%) eyes.
  
  
  CONCLUSIONS
  ARN is a fulminant disorder, which if treated early and aggressively gives good results.
authors.affiliation: Vitreo Retina Services, Aditya Birla Sankara Nethralaya , Kolkata, West Bengal , India .
authors.forename: Rupak
authors.initials: R
authors.lastname: Roy
authors.forename: Bikramjit P
authors.initials: BP
authors.lastname: Pal
authors.forename: Gaurav
authors.initials: G
authors.lastname: Mathur
authors.forename: Chetan
authors.initials: C
authors.lastname: Rao
authors.forename: Debmalya
authors.initials: D
authors.lastname: Das
authors.forename: Jyotirmay
authors.initials: J
authors.lastname: Biswas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage; D002648:Child; D004279:DNA, Viral / Q000032:analysis*; D015828:Eye Infections, Viral / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D005260:Female; D005544:Forecasting; D006563:Herpes Zoster Ophthalmicus / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D014645:Herpesvirus 3, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D058449:Intravitreal Injections; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000209:etiology / Q000517:prevention & control; D015882:Retinal Necrosis Syndrome, Acute / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D012189:Retrospective Studies; D018139:Simplexvirus / Q000235:genetics* / Q000302:isolation & purification; D014792:Visual Acuity; D014822:Vitreous Body / Q000821:virology; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral
keywords: Acute; India; clinical features; management; outcome; retinal necrosis