title: Poor prognosis of ovarian cancer with large cell neuroendocrine carcinoma: case report and review of published works.
abstract: Large cell neuroendocrine carcinoma (LCNEC) is well-reported to result in unfavorable prognoses in many organ cancers while being rarely reported in gynecologic cancer, especially ovarian and endometrial cancers. Here we report a case of ovarian cancer with LCNEC which spread to distant organs within 1 year of primary surgery despite the fact that the post-surgical stage was Ia. The case received platinum-based chemotherapy as an adjuvant therapy after her curative surgery. However, LCNEC in the case was resistant to the chemotherapy. In our review of published works, ovarian cancer cases with LCNEC show poor prognoses regardless of adjuvant chemotherapy following complete resection. Median overall survival was 10 months in stage I cases. Development of chemotherapy sensitive for LCNEC is needed.
authors.forename: Kayo
authors.initials: K
authors.lastname: Asada
authors.forename: Kei
authors.initials: K
authors.lastname: Kawana
authors.forename: Shinichi
authors.initials: S
authors.lastname: Teshima
authors.forename: Ako
authors.initials: A
authors.lastname: Saito
authors.forename: Masakiyo
authors.initials: M
authors.lastname: Kawabata
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Fujii
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D018287:Carcinoma, Large Cell / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000628:therapy; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D019008:Drug Resistance, Neoplasm; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000628:therapy; D011379:Prognosis