title: Tight relationships between B lymphocytes and the skeletal system.
abstract: Mounting evidence indicates that the immune system and the skeletal system share several regulatory nodes. B lymphocytes, which play key roles in immune homeostasis, are uniquely endowed with osteointeractive properties. From their early development to the plasma cell stage, they are in close proximity with the skeletal system and produce factors important for bone maintenance. Not surprisingly, perturbation of B lymphopoiesis affects bone mass. Reciprocally, inactivation of bone cell functions results in B cell development blocks. This new understanding is refining our insights into the pathogenesis of several diseases such as periodontitis and rheumatoid arthritis.
authors.affiliation: Molecular and Cell Biology Unit, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA; Quantitative and Systems Biology Graduate Group, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.
authors.forename: Jennifer O
authors.initials: JO
authors.lastname: Manilay
authors.affiliation: Inserm UMR-S 606 1132, Paris, F-75475, France; Université Paris Diderot, Sorbone Paris Cité, Paris, F-75475, France. Electronic address: moncef.zouali@wanadoo.fr.
authors.forename: Moncef
authors.initials: M
authors.lastname: Zouali
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology*; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D001842:Bone and Bones / Q000276:immunology / Q000473:pathology*; D002450:Cell Communication; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000473:pathology*; D010010:Osteoclasts / Q000276:immunology / Q000473:pathology*; D010518:Periodontitis / Q000276:immunology / Q000473:pathology*
keywords: B lymphocyte; osteoblast; osteoclast; osteocyte; osteoimmunology