title: Human infection with ORF virus from goats in China, 2012.
abstract: Orf virus, which belongs to the Parapoxvirus genus, induces a zoonotic infectious disease characterized by acute, highly vascularized cutaneous pustular lesions in sheep and goats. A number of Orf outbreaks have been reported in sheep and goats in recent years, but no reports have described an Orf virus strain from humans in China. In this study, we diagnosed Orf virus infection in two people, a mother and son, in the Gansu province of China. The human Orf virus was isolated and its phylogenetic characterization was analyzed based on a complete B2L gene. The results are useful for developing prospective programs to control Orf virus infections in both goats and humans.
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute , Chinese Academy of Agricultural Sciences, Lanzhou, China .
authors.forename: Keshan
authors.initials: K
authors.lastname: Zhang
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Liu
authors.forename: Hanjin
authors.initials: H
authors.lastname: Kong
authors.forename: Youjun
authors.initials: Y
authors.lastname: Shang
authors.forename: Xiangtao
authors.initials: X
authors.lastname: Liu
mesh_terms: D000328:Adult; D000818:Animals; D001483:Base Sequence; D002681:China; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005260:Female; D015511:Goat Diseases / Q000821:virology*; D006041:Goats; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009923:Orf virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010802:Phylogeny; D011213:Poxviridae Infections / Q000175:diagnosis* / Q000821:virology; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics; D015047:Zoonoses
chemical_list: D004279:DNA, Viral; D014764:Viral Proteins
references.citation: Vet Microbiol. 2004 Apr 5;99(2):81-92
references.pmid: 15019099
references.citation: Vet Microbiol. 2006 Sep 10;116(4):317-24
references.pmid: 16777357
references.citation: Virol J. 2009 Oct 16;6:167
references.pmid: 19835585
references.citation: Mol Biol Evol. 2011 Oct;28(10):2731-9
references.pmid: 21546353
references.citation: Virus Res. 2003 Jun;93(2):169-79
references.pmid: 12782365
references.citation: J Gen Virol. 2001 May;82(Pt 5):1215-1220
references.pmid: 11297696
references.citation: Pediatr Infect Dis J. 2007 Aug;26(8):740-4
references.pmid: 17848888
references.citation: Emerg Infect Dis. 2013 Jan;19(1):102-5
references.pmid: 23260031
references.citation: Hematol Oncol Clin North Am. 2012 Feb;26(1):31-44
references.pmid: 22244660
references.citation: J Infect Dis. 1973 Jun;127(6):731-2
references.pmid: 4707316
references.citation: J Am Acad Dermatol. 2008 Feb;58(2 Suppl):S39-40
references.pmid: 18191701
references.citation: J Gen Virol. 2004 Jun;85(Pt 6):1413-1418
references.pmid: 15166423
references.citation: New Microbiol. 2011 Jan;34(1):37-43
references.pmid: 21344145
references.citation: Arch Virol. 2013 May;158(5):1105-8
references.pmid: 23247915