title: Circulating adiponectin levels in Indian patients with psoriasis and its relation to metabolic syndrome.
abstract: BACKGROUND
  Adiponectin is a cytokine mainly secreted from the adipose tissue, which has insulin-sensitizing effects, antiatherosclerotic actions, and antiinflammatory properties. There are a few studies that have demonstrated that adiponectin is reduced in patients with psoriasis suggesting that this adipocytokine may have a role in the pathogenesis of psoriasis. There have been no studies so far on adiponectin in relation to psoriasis and metabolic syndrome (MetS).
  
  
  OBJECTIVE
  This study was performed to analyze serum adiponectin and insulin levels in psoriasis patients with and without MetS and in controls with and without MetS.
  
  
  METHODS
  We performed a case control study on 60 psoriasis patients, 29 with MetS and 31 without MetS and 40 controls, 20 with and 20 without MetS, matched for age, sex, and body mass index (BMI). Fasting serum insulin and adiponectin levels were measured in all groups.
  
  
  RESULTS
  The overall serum adiponectin levels were significantly reduced in psoriasis patients when compared with controls (P = 0.000). A significant reduction was also observed in psoriasis patients with MetS than those without MetS in the same group (P = 0.000). Similar decrease was observed between those with MetS in the psoriasis and control groups (P = 0.001). The lowest mean value of serum adiponectin (6387.9 ng/ml) was observed in psoriasis with MetS group and highest value (12146.3 ng/ml) in controls without MetS.
  
  
  CONCLUSIONS
  Adiponectin levels are decreased in psoriasis patients irrespective of MetS thus indicating a role in its pathogenesis. This study prompts future trials on drugs increasing adiponectin levels in patients with psoriasis.
authors.affiliation: Department of Dermatology, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
authors.forename: Shraddha
authors.initials: S
authors.lastname: Madanagobalane
authors.affiliation: Department of Dermatology, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
authors.forename: Venkatswami
authors.initials: V
authors.lastname: Sandhya
authors.affiliation: Department of Dermatology, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
authors.forename: Sankarasubramanian
authors.initials: S
authors.lastname: Anandan
authors.affiliation: Department of Endocrinology and Metabolism, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
authors.forename: Krishna G
authors.initials: KG
authors.lastname: Seshadri
keywords: Psoriasis; metabolic syndrome; serum adiponectin
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