title: MicroRNAs as prognostic markers in ovarian cancer.
abstract: Ovarian cancer (OC) is the most lethal gynecological malignancy among women. Over 70% of women with OC are diagnosed in advanced stages and most of these cases are incurable. Although most patients respond well to primary chemotherapy, tumors become resistant to treatment. Mechanisms of chemoresistance in cancer cells may be associated with mutational events and/or alterations of gene expression through epigenetic events. Although focusing on known genes has already yielded new information, previously unknown non-coding RNAs, such as microRNAs (miRNAs), also lead insight into the biology of chemoresistance. In this review we summarize the current evidence examining the role of miRNAs as biomarkers of response and survival to therapy in OC. Beside their clinical implications, we also discuss important differences between studies that may have limited their use as clinical biomarkers and suggest new approaches.
authors.affiliation: Faculty of Medicine, University of British Columbia, Vancouver, Canada; Research Unit in Biomedicine and Translational Oncology, Vall Hebron Research Institute University Hospital, Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Llauradó
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Vall Hebron Research Institute University Hospital, Barcelona, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Majem
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Vall Hebron Research Institute University Hospital, Barcelona, Spain.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Altadill
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Vall Hebron Research Institute University Hospital, Barcelona, Spain.
authors.forename: Lucia
authors.initials: L
authors.lastname: Lanau
authors.affiliation: Department of Pathology, Vall Hebron University Hospital, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Castellví
authors.affiliation: Department of Gynecological Oncology, Vall Hebron University Hospital, Barcelona, Spain.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Sánchez-Iglesias
authors.affiliation: Department of Gynecological Oncology, Vall Hebron University Hospital, Barcelona, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Cabrera
authors.affiliation: Department of Gynecological Oncology, Vall Hebron University Hospital, Barcelona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: De la Torre
authors.affiliation: Department of Gynecological Oncology, Vall Hebron University Hospital, Barcelona, Spain.
authors.forename: Berta
authors.initials: B
authors.lastname: Díaz-Feijoo
authors.affiliation: Department of Gynecological Oncology, Vall Hebron University Hospital, Barcelona, Spain.
authors.forename: Asuncion
authors.initials: A
authors.lastname: Pérez-Benavente
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Vall Hebron Research Institute University Hospital, Barcelona, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Colás
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Vall Hebron Research Institute University Hospital, Barcelona, Spain.
authors.forename: Mireia
authors.initials: M
authors.lastname: Olivan
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Vall Hebron Research Institute University Hospital, Barcelona, Spain.
authors.forename: Andreas
authors.initials: A
authors.lastname: Doll
authors.affiliation: Department of Pathology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Alameda
authors.affiliation: Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLLEIDA, Lleida, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Matias-Guiu
authors.affiliation: Departamento de Bioquímica, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, 28029, Madrid, Spain & Fundación MD Anderson Internacional, 28033 Madrid, Spain.
authors.forename: Gema
authors.initials: G
authors.lastname: Moreno-Bueno
authors.affiliation: Division of Gynecologic Oncology, University of British Columbia and BC Cancer Agency, Vancouver, BC, Canada.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Carey
authors.affiliation: Division of Gynecology and Head and Neck, Department of Oncology, Vall Hebron University Hospital, Barcelona, Spain.
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Del Campo
authors.affiliation: Department of Gynecological Oncology, Vall Hebron University Hospital, Barcelona, Spain; Faculty of Medicine, Autonomous University of Barcelona, Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gil-Moreno
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Vall Hebron Research Institute University Hospital, Barcelona, Spain; Faculty of Medicine, Autonomous University of Barcelona, Barcelona, Spain; Departament de Ciències Bàsiques, Universitat Internacional de Catalunya, Barcelona, Spain; IDIBELL- Bellvitge Biomedical Research Institute, Barcelona, Spain. Electronic address: jaume.reventos@vhir.org.
authors.forename: Jaume
authors.initials: J
authors.lastname: Reventós
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Vall Hebron Research Institute University Hospital, Barcelona, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Rigau
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D005260:Female; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D011379:Prognosis; D034622:RNA Interference
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Chemotherapy; Ovarian cancer; Prediction; Prognosis; Tumor resistance; miRNAs