title: Effect of chromium on antioxidant potential of Catharanthus roseus varieties and production of their anticancer alkaloids: vincristine and vinblastine.
abstract: Catharanthus roseus (L.) G. Don, a medicinal plant, has a very important place in the traditional as well as modern pharmaceutical industry. Two common varieties of this plant rosea and alba are named so because of pink and white coloured flowers, respectively. This plant comprises of about 130 terpenoid indole alkaloids and two of them, vincristine and vinblastine, are common anticancer drugs. The effect of chromium (Cr) on enzymatic and non-enzymatic antioxidant components and on secondary metabolites vincristine and vinblastine was studied under pot culture conditions of both varieties of C. roseus. Antioxidant responses of these varieties were analyzed under 0, 10, 50, and 100  μM chromium (Cr) level in order to investigate the plant's protective mechanisms against Cr induced oxidative stress. The results indicated that Cr affects all the studied parameters and decreases growth performance. However, vincristine and vinblastine contents were increased under Cr stress. Results are quite encouraging, as this plant shows good antioxidant potential and increased the level of active constituents under Cr stress.
authors.affiliation: Department of Botany, University of Lucknow, Lucknow 226 007, India.
authors.forename: Vartika
authors.identifier: 0000-0001-8326-1801
authors.initials: V
authors.lastname: Rai
authors.affiliation: Department of Botany, University of Lucknow, Lucknow 226 007, India.
authors.forename: Pramod Kumar
authors.initials: PK
authors.lastname: Tandon
authors.affiliation: Pharmacognosy & Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow 226 001, India.
authors.forename: Sayyada
authors.initials: S
authors.lastname: Khatoon
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry*; D002338:Carotenoids / Q000737:chemistry; D030008:Catharanthus / Q000378:metabolism*; D002734:Chlorophyll / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D002857:Chromium / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015227:Lipid Peroxidation; D018384:Oxidative Stress; D010539:Permeability; D010936:Plant Extracts / Q000737:chemistry*; D011392:Proline / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D014747:Vinblastine / Q000737:chemistry*; D014750:Vincristine / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D010936:Plant Extracts; D013438:Sulfhydryl Compounds; D002857:Chromium; D002734:Chlorophyll; D002338:Carotenoids; D014750:Vincristine; D014747:Vinblastine; D011392:Proline; D003545:Cysteine
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