title: Clinical utility of etanercept in the treatment of arthritides in children and adolescents.
abstract: Juvenile idiopathic arthritis (JIA) is a group of chronic inflammatory diseases affecting approximately 300,000 children and adolescents in the United States of unknown cause. It can affect children from the age of 0 years up to the age of 16 years. The International League of Associations of Rheumatology has defined seven subsets of JIA based on several factors including the number of affected joints and the involvement of other tissues; the prognosis for each affected child also depends on multiple factors including age of onset, number of joints involved, and systemic features. As with rheumatoid arthritis in adults, the goal of therapy is remission and resolution of disease activity; however, as a cure does not seem attainable in the near future, a reasonable goal of therapy is prevention of joint damage, inhibition of inflammation, and a high level of quality of life. Even with available therapies, many children with JIA enter adulthood with persistently active disease, suboptimal function, and impaired quality of life. Methotrexate remains the standard of care for children with JIA; etanercept was approved in 2000 in the United States for the treatment of JIA resistant to methotrexate. The efficacy and safety of etanercept therapy in children with JIA is reviewed and its place in the therapeutic regimen is discussed; the available long term data is also presented. The data presented was obtained from a PubMed search as well as a review of the references presented in the 2011 American College of Rheumatology Recommendations for the Treatment of Juvenile Idiopathic Arthritis and the 2013 Update. It is hoped that treatment with etanercept and other biologic therapies will lead to improved outcomes for children with JIA in the future.
authors.affiliation: David Geffen School of Medicine, Division of Rheumatology, UCLA, Los Angeles, CA, USA.
authors.forename: Robin K
authors.initials: RK
authors.lastname: Dore
keywords: etanercept; juvenile chronic arthritis; juvenile idiopathic arthritis; juvenile rheumatoid arthritis
references.citation: J Pediatr. 1998 Aug;133(2):262-5
references.pmid: 9709717
references.citation: Arthritis Care Res (Hoboken). 2012 Sep;64(9):1357-64
references.pmid: 22511558
references.citation: Pediatr Dermatol. 2012 Jul-Aug;29(4):454-9
references.pmid: 21995665
references.citation: J Rheumatol. 2012 Jun;39(6):1287-90
references.pmid: 22589254
references.citation: Rheumatol Int. 2012 Sep;32(9):2675-9
references.pmid: 21789614
references.citation: Ann Rheum Dis. 2001 Apr;60(4):410-2
references.pmid: 11247875
references.citation: Clin Exp Rheumatol. 2002 Nov-Dec;20(6):867-70
references.pmid: 12508784
references.citation: J Rheumatol. 2004 Feb;31(2):390-2
references.pmid: 14760812
references.citation: JAMA. 2011 Dec 7;306(21):2340-7
references.pmid: 22056397
references.citation: Rheumatol Int. 2010 Apr;30(6):801-4
references.pmid: 19506877
references.citation: J Clin Invest. 2007 Dec;117(12):3833-45
references.pmid: 17992258
references.citation: Arthritis Rheum. 2012 Jun;64(6):2012-21
references.pmid: 22183975
references.citation: Pediatrics. 2002 Jan;109(1):109-15
references.pmid: 11773549
references.citation: Arthritis Rheum. 2010 Dec;62(12):3776-82
references.pmid: 20827782
references.citation: Arthritis Care Res (Hoboken). 2011 Apr;63(4):465-82
references.pmid: 21452260
references.citation: Curr Eye Res. 2010 Aug;35(8):751-6
references.pmid: 20673052
references.citation: J Rheumatol. 2011 Apr;38(4):760-3
references.pmid: 21239753
references.citation: Pediatr Neurol. 2011 Oct;45(4):271-3
references.pmid: 21907894
references.citation: Ann Rheum Dis. 2008 Aug;67(8):1145-52
references.pmid: 17981916
references.citation: Clin Exp Rheumatol. 2010 Nov-Dec;28(6):919-22
references.pmid: 21205467
references.citation: Pediatr Rheumatol Online J. 2013 Oct 02;11(1):35
references.pmid: 24225257
references.citation: Clin Rheumatol. 1998;17(4):288-92
references.pmid: 9776110
references.citation: J Clin Rheumatol. 2013 Apr;19(3):129-31
references.pmid: 23519173
references.citation: Clin Exp Rheumatol. 2003 Mar-Apr;21(2):276-7
references.pmid: 12747299
references.citation: Arthritis Rheum. 1995 Feb;38(2):211-20
references.pmid: 7848311
references.citation: Ann Rheum Dis. 2009 Apr;68(4):519-25
references.pmid: 18413440
references.citation: Arthritis Rheum. 1996 Aug;39(8):1385-90
references.pmid: 8702448
references.citation: Arthritis Rheum. 1997 Jul;40(7):1202-9
references.pmid: 9214419
references.citation: Case Rep Rheumatol. 2011;2011:134106
references.pmid: 22937436
references.citation: Arthritis Rheum. 1988 Mar;31(3):315-24
references.pmid: 3358796
references.citation: Clin Exp Rheumatol. 2008 Jul-Aug;26(4):688-92
references.pmid: 18799107
references.citation: Rheumatology (Oxford). 2009 Aug;48(8):916-9
references.pmid: 19483091
references.citation: BMC Pediatr. 2012 Mar 15;12:29
references.pmid: 22420649
references.citation: Ann Rheum Dis. 2014 Jun;73(6):1114-22
references.pmid: 23696632
references.citation: J Rheumatol. 2013 Feb;40(2):192-200
references.pmid: 23204218
references.citation: J Rheumatol. 2012 Feb;39(2):233-9
references.pmid: 22174213
references.citation: Arthritis Rheum. 2013 Oct;65(10):2499-512
references.pmid: 24092554
references.citation: N Engl J Med. 2000 Mar 16;342(11):763-9
references.pmid: 10717011
references.citation: J Rheumatol. 2010 Mar;37(3):665-7
references.pmid: 20080910
references.citation: Rheumatology (Oxford). 2013 Apr;52(4):712-7
references.pmid: 23267169
references.citation: Clin Exp Rheumatol. 2011 Jan-Feb;29(1):131-9
references.pmid: 21345300
references.citation: Mod Rheumatol. 2013 Mar;23(2):397-400
references.pmid: 22669598
references.citation: Rheumatology (Oxford). 2010 Aug;49(8):1550-8
references.pmid: 20444859
references.citation: J Rheumatol. 2007 Dec;34(12):2503-4
references.pmid: 18061971
references.citation: Ann Rheum Dis. 2013 May;72(5):721-7
references.pmid: 22730374
references.citation: Clin Rheumatol. 2010 Jun;29(6):677-81
references.pmid: 20383549
references.citation: Arthritis Rheum. 1993 Oct;36(10):1370-4
references.pmid: 8216396
references.citation: Arthritis Rheum. 2008 May;58(5):1496-504
references.pmid: 18438876
references.citation: Rheumatol Int. 2009 Mar;29(5):591-3
references.pmid: 18810448
references.citation: Rheumatol Int. 2013 Oct;33(10):2657-60
references.pmid: 22821261
references.citation: Arthritis Care Res (Hoboken). 2012 Sep;64(9):1382-91
references.pmid: 22504893
references.citation: Ann Rheum Dis. 2002 Feb;61(2):171-3
references.pmid: 11796406
references.citation: Arthritis Rheum. 2010 Nov;62(11):3259-64
references.pmid: 20669280
references.citation: Arthritis Rheum. 2009 Sep;60(9):2794-804
references.pmid: 19714630