title: The epidemiology and clinical implications of genetic variation in prostate cancer.
abstract: There is strong evidence of a genetic predisposition to prostate cancer. Recent advances in genetic sequencing technologies have permitted significant advances in the field. This article reviews the genetic basis underlying prostate cancer, and highlights the epidemiology and potential clinical usefulness of both rare and common genetic variations. In addition, recent findings related to the understanding of prostate cancer genetics are discussed.
authors.affiliation: Department of Surgery, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, 2650 Ridge Avenue, Evanston, IL 60201, USA. Electronic address: bhelfand@northshore.org.
authors.forename: Brian T
authors.initials: BT
authors.lastname: Helfand
authors.affiliation: Department of Urology, Feinberg School of Medicine, Northwestern University, 303 East Superior Avenue, Terry Building 16, Chicago, IL 60611, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Catalona
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D014943:Global Health; D006801:Humans; D008297:Male; D009017:Morbidity / Q000639:trends; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm
keywords: Genetic variants; Prostate cancer; Susceptibility; Tumor aggressiveness