title: Management of a pemphigus with IgA and IgG antibodies and coexistent lung cancer.
abstract: Immunoglobulin A (IgA) pemphigus is a clinically distinct variant of pemphigus characterized by intercellular IgA deposition in the epidermis. Recently, an IgA/Immunoglobulin G (IgG) subset of pemphigus with IgA and IgG anti-keratinocyte cell surface antibodies has been described. Both IgA and IgA/IgG pemphigus have been associated with internal malignancies. Above all, monoclonal IgA gammopathy in patients with IgA pemphigus has been reported, and lung cancers in association with IgA/IgG pemphigus have been described. IgA pemphigus can be successfully treated with dapsone, whereas therapeutic management of IgG/IgA pemphigus is not well established yet. We report a rare case of a patient, who developed atypical pemphigus with both IgA and IgG autoantibodies and an underlying lung cancer, successfully treated with corticosteroids and dapsone.
authors.affiliation: Medical Faculty and Teaching Hospital Pilsen, Department of Dermatology and Venereology, Charles University, Pilsen, Czech Republic.
authors.forename: Petra
authors.initials: P
authors.lastname: Cetkovská
authors.forename: Michaela
authors.initials: M
authors.lastname: Komorousová
authors.forename: Iva
authors.initials: I
authors.lastname: Lomicová
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000276:immunology; D003622:Dapsone / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D010392:Pemphigus / Q000188:drug therapy* / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D005938:Glucocorticoids; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D003622:Dapsone
keywords: IgA/IgG pemphigus; dapsone; lung cancer