title: Gastroprotective effect of minocycline in experimentally induced gastric ulcers in rats.
abstract: Minocycline (MCN), a semi-synthetic tetracycline derivative possesses pleiotropic effects and provides protection against a number of disease models. However its effect on gastric ulcers has not been studied. The present investigation was undertaken, to study the gastro-protective potential of MCN in experimentally induced gastric ulcers in rats. MCN (10, 30, 100 mg/Kg) was tested for gastric secretion and antiulcer activity in different groups of Wistar rats. Gastric secretion and acidity studies were performed in pylorus ligated rats while indices of gastric ulcers were measured in ethanol (1 ml-100%) and indomethacin (30 mg/kg), induced gastric ulcers. Histological changes and the levels of gastric wall mucus, malondialdehyde (MDA), non-protein sulfhydryl (NP-SH), and myeloperoxidase (MPO), were used to assess ethanol induced gastric mucosal injuries. Exposure of rats to ulcerogens resulted in gastric mucosal injury and a significant increase in the indices of ulcer. MCN conferred a protective effect against ethanol, and indomethacin induced gastric mucosal injuries. Treatment with MCN, resulted in a significant decrease in the amount of gastric secretion, and total acidity and significantly (P<0.001), reduced the gastric lesions induced by ethanol and indomethacin. MCN also significantly attenuated the ethanol induced reduction in the levels of gastric wall mucus, and NP-SH (P<0.001). The histological changes and the increased MDA and MPO activity were also significantly (P<0.001) inhibited by MCN. Minocycline showed significant antiulcer and gastroprotective activity against experimentally induced gastric ulcers. The gastroprotective effects of minocycline may be due to its anti-secretory, antioxidant and anti inflammatory action.
authors.affiliation: Research Center, Prince Sultan Military Medical City Riyadh, Saudi Arabia.
authors.forename: Abdulrahman Al
authors.initials: AA
authors.lastname: Asmari
authors.affiliation: Department of Surgery, Prince Sultan Military Medical City Riyadh, Saudi Arabia.
authors.forename: Saud Al
authors.initials: SA
authors.lastname: Omani
authors.affiliation: Department of Gastroenterology, Prince Sultan Military Medical City Riyadh, Saudi Arabia.
authors.forename: Malfi Al
authors.initials: MA
authors.lastname: Otaibi
authors.affiliation: Department of Hematology, Prince Sultan Military Medical City Riyadh, Saudi Arabia.
authors.forename: Abdul-Aziz Al
authors.initials: AA
authors.lastname: Abdulaaly
authors.affiliation: Research Center, Prince Sultan Military Medical City Riyadh, Saudi Arabia.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Elfaki
authors.affiliation: Department of Pharmacy, Prince Sultan Military Medical City Riyadh, Saudi Arabia.
authors.forename: Khalid Al
authors.initials: KA
authors.lastname: Yahya
authors.affiliation: Research Center, Prince Sultan Military Medical City Riyadh, Saudi Arabia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Arshaduddin
keywords: Gastric ulcer; ethanol; indomethacin; minocycline; myeloperoxidase; oxidative stress
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