title: Neuropsychological features of adult mastocytosis.
abstract: In approximately one-third of cases, patients with mastocytosis can display various disabling general and neuropsychological symptoms. General signs may have a major impact on quality of life. Neurologic symptoms are less frequent. In a majority of cases, the pathophysiology of these symptoms is not known but could be linked to tissular mast cell infiltration, mast cell mediator release, or both. Treatments aiming at reducing mast cell number and/or stabilizating mast cells may be useful. Preliminary results suggest that treatment with kinase inhibitors may improve symptoms of depression and cognitive impairment.
authors.affiliation: INSERM UMR 1163, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris, France; Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Paris, France; CNRS ERL 8254, Paris, France; Laboratory of Excellence GR-Ex, Paris, France; Service d'Hématologie clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France.
authors.forename: Daniela S
authors.initials: DS
authors.lastname: Moura
authors.affiliation: INSERM UMR 1163, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris, France; Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Paris, France; CNRS ERL 8254, Paris, France; Laboratory of Excellence GR-Ex, Paris, France; Service d'Hématologie clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France; Service de médecine Interne, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, 4 rue de la chine, Paris 75020, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Georgin-Lavialle
authors.affiliation: Laboratoire de "Physiopathologie des maladies Psychiatriques", Centre de Psychiatrie et Neurosciences, U894, INSERM, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Service de Psychiatrie, Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Gaillard
authors.affiliation: INSERM UMR 1163, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris, France; Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Paris, France; CNRS ERL 8254, Paris, France; Laboratory of Excellence GR-Ex, Paris, France; Service d'Hématologie clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France. Electronic address: ohermine@gmail.com.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
mesh_terms: D000328:Adult; D001007:Anxiety / Q000150:complications / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology*; D003072:Cognition Disorders / Q000150:complications / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D003863:Depression / Q000150:complications / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D006801:Humans; D008407:Mast Cells / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008415:Mastocytosis / Q000150:complications / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D008881:Migraine Disorders / Q000150:complications / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D019009:Proto-Oncogene Proteins c-kit / Q000037:antagonists & inhibitors / Q000378:metabolism; D011619:Psychotropic Drugs / Q000627:therapeutic use; D011788:Quality of Life
chemical_list: D047428:Protein Kinase Inhibitors; D011619:Psychotropic Drugs; D019009:Proto-Oncogene Proteins c-kit
keywords: Anxiety; Cognitive impairment; Depression; Headache; Kit; Mast cell; Mastocytosis