title: Developmental venous anomaly in the newborn brain.
abstract: BACKGROUND
  Cerebral developmental venous anomaly (DVA) is considered a benign anatomical variant of parenchymal venous drainage; it is the most common vascular malformation seen in the adult brain. Despite its assumed congenital origin, little is known about DVA in the neonatal brain. We report here the first cohort study of 14 neonates with DVA.
  
  
  METHODS
  Fourteen infants (seven preterm) with DVA diagnosed neonatally using cranial ultrasound (cUS) and magnetic resonance imaging (MRI) from three tertiary neonatal units over 14 years are reviewed.
  
  
  RESULTS
  DVA was first detected on cUS in 6 and on MRI in 8 of the 14 infants. The cUS appearances of DVA showed a focal fairly uniform area of increased echogenicity, often (86 %) adjacent to the lateral ventricle and located in the frontal lobe (58 %). Blood flow in the dilated collector vein detected by Doppler ultrasound (US) varied between cases (venous flow pattern in ten and arterialized in four). The appearance on conventional MRI was similar to findings in adults. Serial imaging showed a fairly constant appearance to the DVAs in some cases while others varied considerably regarding anatomical extent and flow velocity.
  
  
  CONCLUSIONS
  This case series underlines that a neonatal diagnosis of DVA is possible with carefully performed cUS and MRI and that DVA tends to be an incidental finding with a diverse spectrum of imaging appearances. Serial imaging suggests that some DVAs undergo dynamic changes during the neonatal period and early infancy; this may contribute to why diagnosis is rare at this age.
authors.affiliation: Department of Neonatology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands, s.horsch@gmx.de.
authors.forename: S
authors.initials: S
authors.lastname: Horsch
authors.forename: P
authors.initials: P
authors.lastname: Govaert
authors.forename: F M
authors.initials: FM
authors.lastname: Cowan
authors.forename: M J N L
authors.initials: MJ
authors.lastname: Benders
authors.forename: F
authors.initials: F
authors.lastname: Groenendaal
authors.forename: M H
authors.initials: MH
authors.lastname: Lequin
authors.forename: G
authors.initials: G
authors.lastname: Saliou
authors.forename: L S
authors.initials: LS
authors.lastname: de Vries
mesh_terms: D020785:Central Nervous System Vascular Malformations / Q000473:pathology*; D002550:Cerebral Veins / Q000002:abnormalities* / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
references.citation: Neuroradiology. 2009 Jan;51(1):25-32
references.pmid: 18787814
references.citation: Surg Neurol. 1986 Mar;25(3):227-32
references.pmid: 3945903
references.citation: Placenta. 2012 Apr;33(4):285-93
references.pmid: 22264586
references.citation: Neurosurgery. 1993 Aug;33(2):179-88; discussion 188
references.pmid: 8367039
references.citation: AJR Am J Roentgenol. 1992 Dec;159(6):1299-307
references.pmid: 1442406
references.citation: Pediatrics. 2006 Aug;118(2):536-48
references.pmid: 16882805
references.citation: Neuroradiology. 2000 Jun;42(6):455-7
references.pmid: 10929309
references.citation: Neuroradiology. 1993;35(2):97-104
references.pmid: 8433801
references.citation: Pediatr Neurol. 2005 Jan;32(1):53-5
references.pmid: 15607606
references.citation: Neurosurgery. 1998 Aug;43(2):195-200; discussion 200-1
references.pmid: 9696070
references.citation: Neuroradiology. 2007 Dec;49(12):987-95
references.pmid: 17703296
references.citation: Semin Perinatol. 2008 Jun;32(3):172-7
references.pmid: 18482617
references.citation: Neurosurgery. 1998 Aug;43(2):347-51; discussion 351-2
references.pmid: 9696089
references.citation: Childs Nerv Syst. 2010 Oct;26(10):1395-406
references.pmid: 20703485
references.citation: Arch Neurol. 1978 May;35(5):323-5
references.pmid: 646686
references.citation: AJNR Am J Neuroradiol. 1996 Jan;17(1):61-70
references.pmid: 8770251
references.citation: Neuropathology. 1999 Jan;19(1):93-111
references.pmid: 19519653
references.citation: Pediatr Radiol. 2010 Mar;40(3):374
references.pmid: 19727698
references.citation: Radiology. 1981 Apr;139(1):87-94
references.pmid: 7208947
references.citation: J Neurosurg. 1991 Nov;75(5):715-22
references.pmid: 1919693
references.citation: Neuroradiology. 2007 Feb;49(2):161-7
references.pmid: 17119946
references.citation: AJNR Am J Neuroradiol. 1997 Nov-Dec;18(10):1839-46
references.pmid: 9403438
references.citation: Ann Neurol. 2009 Sep;66(3):271-83
references.pmid: 19798638
references.citation: J Neurol Sci. 2009 Dec 15;287(1-2):7-16
references.pmid: 19772973
references.citation: Thromb Haemost. 2001 Oct;86(4):1012-6
references.pmid: 11686317
references.citation: Acta Neurochir (Wien). 2001 Oct;143(10):997-1004
references.pmid: 11685606
references.citation: AJNR Am J Neuroradiol. 1994 Nov;15(10):1871-83
references.pmid: 7863937
references.citation: Neuroradiology. 2011 Sep;53(9):669-79
references.pmid: 21553013
references.citation: Clin Radiol. 2003 Mar;58(3):251-6
references.pmid: 12639533
references.citation: Neurosurg Rev. 1986;9(3):233-42
references.pmid: 3550523
references.citation: J Neurosurg. 2008 Jun;108(6):1142-7
references.pmid: 18518718
references.citation: J Neuroradiol. 1988;15(3):205-24
references.pmid: 3246599
references.citation: Neuroradiology. 2012 May;54(5):475-80
references.pmid: 21667050
references.citation: Stroke. 2008 Dec;39(12):3201-15
references.pmid: 18988912