title: Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction.
abstract: Increased oxidative stress and reduced nitric oxide (NO) bioavailability play a causal role in endothelial cell dysfunction occurring in the vasculature of diabetic patients. In this review, we summarized the molecular mechanisms underpinning diabetic endothelial and vascular dysfunction. In particular, we focused our attention on the complex interplay existing among NO, reactive oxygen species (ROS), and one crucial regulator of intracellular ROS production, p66Shc protein.
authors.affiliation: Vascular Pathology Laboratory, Istituto Dermopatico dell'Immacolata-IRCCS, 00167 Rome, Italy.
authors.forename: Alessandra
authors.identifier: 0000-0002-9054-337X
authors.initials: A
authors.lastname: Magenta
authors.affiliation: Molecular Cardiology Laboratory, Policlinico San Donato-IRCCS, San Donato Milanese, 20097 Milan, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Greco
authors.affiliation: Vascular Pathology Laboratory, Istituto Dermopatico dell'Immacolata-IRCCS, 00167 Rome, Italy.
authors.forename: Maurizio C
authors.initials: MC
authors.lastname: Capogrossi
authors.affiliation: Division of Cardiovascular Epigenetics, Department of Cardiology, Internal Medicine Clinic III, Goethe University, 60590 Frankfurt am Main, Germany.
authors.forename: Carlo
authors.initials: C
authors.lastname: Gaetano
authors.affiliation: Molecular Cardiology Laboratory, Policlinico San Donato-IRCCS, San Donato Milanese, 20097 Milan, Italy.
authors.forename: Fabio
authors.identifier: 0000-0002-8624-7738
authors.initials: F
authors.lastname: Martelli
mesh_terms: D000375:Aging; D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D044127:Epigenesis, Genetic; D006801:Humans; D006861:Hydrogen Peroxide; D006937:Hypercholesterolemia / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism; D009569:Nitric Oxide / Q000737:chemistry*; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D055765:Shc Signaling Adaptor Proteins / Q000378:metabolism*; D015398:Signal Transduction; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1; D014652:Vascular Diseases / Q000503:physiopathology*
chemical_list: D007328:Insulin; D035683:MicroRNAs; D017382:Reactive Oxygen Species; C528024:SHC1 protein, human; D055765:Shc Signaling Adaptor Proteins; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; D052250:Nitric Oxide Synthase Type III
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