title: HLA-G dimers in the prolongation of kidney allograft survival.
abstract: Human leukocyte antigen-G (HLA-G) contributes to acceptance of allografts in solid organ/tissue transplantation. Most studies have determined that soluble HLA-G isoforms are systematically detected in serum/plasma of transplanted patients with significantly fewer episodes of acute and/or chronic rejection of allogeneic tissue/organ. Current models of the interactions of HLA-G and its specific receptors explain it as functioning in a monomeric form. However, in recent years, new data has revealed the ability of HLA-G to form disulfide-linked dimeric complexes with high preferential binding and functional activities. Limited data are available on the role of soluble HLA-G dimers in clinical pathological conditions. We describe here the presence of soluble HLA-G dimers in kidney transplant patients. Our study showed that a high level of HLA-G dimers in plasma and increased expression of the membrane-bound form of HLA-G on monocytes are associated with prolongation of kidney allograft survival. We also determined that the presence of soluble HLA-G dimers links to the lower levels of proinflammatory cytokines, suggesting a potential role of HLA-G dimers in controlling the accompanying inflammatory state.
authors.affiliation: Molecular Oncology and Biomarkers Program, Cancer Center, Department of Medicine, Georgia Regents University, 1410 Laney Walker Boulevard, Augusta, GA 30912, USA.
authors.forename: Maureen
authors.initials: M
authors.lastname: Ezeakile
authors.affiliation: Molecular Oncology and Biomarkers Program, Cancer Center, Department of Medicine, Georgia Regents University, 1410 Laney Walker Boulevard, Augusta, GA 30912, USA.
authors.forename: Vera
authors.initials: V
authors.lastname: Portik-Dobos
authors.affiliation: Molecular Oncology and Biomarkers Program, Cancer Center, Department of Medicine, Georgia Regents University, 1410 Laney Walker Boulevard, Augusta, GA 30912, USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Wu
authors.affiliation: Molecular Oncology and Biomarkers Program, Cancer Center, Department of Medicine, Georgia Regents University, 1410 Laney Walker Boulevard, Augusta, GA 30912, USA.
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Horuzsko
authors.affiliation: Section of Nephrology, Hypertension, and Transplantation Medicine, Department of Medicine, Georgia Regents University, Augusta, GA 30912, USA.
authors.forename: Rajan
authors.initials: R
authors.lastname: Kapoor
authors.affiliation: Section of Nephrology, Hypertension, and Transplantation Medicine, Department of Medicine, Georgia Regents University, Augusta, GA 30912, USA.
authors.forename: Muralidharan
authors.initials: M
authors.lastname: Jagadeesan
authors.affiliation: Section of Nephrology, Hypertension, and Transplantation Medicine, Department of Medicine, Georgia Regents University, Augusta, GA 30912, USA.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Mulloy
authors.affiliation: Molecular Oncology and Biomarkers Program, Cancer Center, Department of Medicine, Georgia Regents University, 1410 Laney Walker Boulevard, Augusta, GA 30912, USA.
authors.forename: Anatolij
authors.initials: A
authors.lastname: Horuzsko
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002462:Cell Membrane / Q000378:metabolism; D016207:Cytokines / Q000097:blood; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology*; D059951:HLA-G Antigens / Q000097:blood / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D016030:Kidney Transplantation; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D020033:Protein Isoforms; D055503:Protein Multimerization; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D059951:HLA-G Antigens; D018836:Inflammation Mediators; D020033:Protein Isoforms; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9
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