title: Microbial production of specialty organic acids from renewable and waste materials.
abstract: Microbial production of organic acids has become a fast-moving field due to the increasing role of these compounds as platform chemicals. In recent years, the portfolio of specialty fermentation-derived carboxylic acids has increased considerably, including the production of glyceric, glucaric, succinic, butyric, xylonic, fumaric, malic, itaconic, lactobionic, propionic and adipic acid through innovative fermentation strategies. This review summarizes recent trends in the use of novel microbial platforms as well as renewable and waste materials for efficient and cost-effective bio-based production of emerging high-value organic acids. Advances in the development of robust and efficient microbial bioprocesses for producing carboxylic acids from low-cost feedstocks are also discussed. The industrial market scenario is also reviewed, including the latest information on the stage of development for producing these emerging bio-products via large-scale fermentation.
authors.affiliation: a Department of Chemical Engineering and Environmental Technology, Faculty of Chemistry , University of Oviedo , Oviedo , Spain.
authors.forename: Saúl
authors.initials: S
authors.lastname: Alonso
authors.affiliation: a Department of Chemical Engineering and Environmental Technology, Faculty of Chemistry , University of Oviedo , Oviedo , Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Rendueles
authors.affiliation: a Department of Chemical Engineering and Environmental Technology, Faculty of Chemistry , University of Oviedo , Oviedo , Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: Díaz
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry* / Q000378:metabolism; D005285:Fermentation; D060847:Metabolic Engineering; D014866:Waste Products
chemical_list: D002264:Carboxylic Acids; D014866:Waste Products
keywords: Bio-based production; microbial fermentation; microbial platforms; non-food feedstocks; organic acids; renewable resources