title: A colonization of basal cell carcinoma by malignant melanoma in situ resembling a malignant basomelanocytic tumor.
abstract: We report a case of colonization of basal cell carcinoma (BCC) by malignant melanoma in situ (MIS) simulating a malignant basomelanocytic tumor. A biopsy of a pigmented lesion present on an 83-year-old man's scalp displayed intimate admixing of basaloid and melanocytic cells. This seemingly inseparable combination of BCC and neoplastic melanocytes has been referred to as a malignant basomelanocytic tumor. However, our case also displays an adjacent component of MIS, thus favoring colonization of BCC by MIS as the etiology. To our knowledge, this is the third case report of colonization of BCC by MIS resembling a malignant basomelanocytic tumor.
authors.affiliation: *University of Nebraska Medical School, Omaha, NE; and †Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE.
authors.forename: Megan
authors.initials: M
authors.lastname: Goeser
authors.forename: Dominick J
authors.initials: DJ
authors.lastname: DiMaio
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000473:pathology*; D003937:Diagnosis, Differential; D006258:Head and Neck Neoplasms / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008544:Melanocytes / Q000737:chemistry / Q000473:pathology*; D008545:Melanoma / Q000737:chemistry / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology*; D011237:Predictive Value of Tests; D012535:Scalp / Q000737:chemistry / Q000473:pathology*; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*; D000096142:Cutaneous Malignant Melanoma
chemical_list: D014408:Biomarkers, Tumor