title: [Use of mathematical models infrared spectroscopy serum in the differential diagnosis of ulcerative colitis and Crohn's disease in children].
abstract: RELEVANCE OF RESEARCH: Inflammatory bowel diseases are among the most severe pathologies in pediatric gastroenterology, often lead to disability. Despite the similarity of the clinic, pathogenetic mechanisms, the question of the differential diagnosis of ulcerative colitis and Crohn's disease is relevant in view of their different prognosis and treatment strategy. In recent years, in medical uses infrared spectroscopy of blood serum for the differential diagnosis of various inflammatory diseases, benign and malignant tumors. Besides finding increasing application of mathematical methods for data processing, the so-called mathematical modeling of pathological processes, allowing objectify the survey results for a more accurate diagnosis and prognosis of pathological processes.
  
  
  OBJECTIVE
  improving the differential diagnosis of ulcerative colitis and Crohn's disease in children.
  
  
  METHODS
  21 children with ulcerative colitis, 56 children with Crohn's disease and 34 healthy children. The method of infrared spectroscopy of serum and mathematical modeling results through multivariate entropy analysis.
  
  
  RESULTS
  the obtained spectral characteristics of blood serum in children with ulcerative colitis and Crohn's disease and in healthy children, as well as "images of diseased in these pathologies".
  
  
  CONCLUSIONS
  The use of this medical technology reduced the time of diagnosis, which contributes to the timely choice of rational treatment strategies and provides an opportunity to avoid the development of complications, worsening of the disease.
authors.forename: É N
authors.initials: ÉN
authors.lastname: Fedulova
authors.forename: A S
authors.initials: AS
authors.lastname: Gordetsov
authors.forename: O V
authors.initials: OV
authors.lastname: Fedorova
authors.forename: L V
authors.initials: LV
authors.lastname: Korkotashvili
authors.forename: O A
authors.initials: OA
authors.lastname: Tutina
mesh_terms: D002648:Child; D003093:Colitis, Ulcerative / Q000175:diagnosis*; D003424:Crohn Disease / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008962:Models, Theoretical; D015203:Reproducibility of Results; D013055:Spectrophotometry, Infrared / Q000379:methods*