title: Inflammatory myofibroblastic tumors of the nasal cavity and paranasal sinus: a clinicopathologic study of 25 cases and review of the literature.
abstract: Inflammatory myofibroblastic tumor (IMT) is rare in nasal cavity and paranasal sinus. The aim of this study was to describe the clinicopathological features of sinonasal IMT and analyze the relationship between the clinicopathological features and the prognosis. A retrospective study of 25 IMT patients between 2001 and 2012 was performed. Data on clinical features, treatment, and follow-up were recorded. The histological characters were observed. Overall survival (OS) and event-free survival (EFS) were estimated using the Kaplan-Meier method. Clinically, the most common symptoms were nasal obstruction, facial pain, and toothache. Twenty patients received follow-ups 6-120 months after initial diagnosis. Fifteen (75 %) developed recurrence 1 or more times. One patient had left cervical lymph node metastasis (5 %). Five patients died of the tumor (25 %). Histologically, the IMTs composed of bland spindle cells admixed with a prominent infiltrate of plasma cells and lymphocytes and showed obvious atypia in recurrent cases. Histology with necrosis, mitosis (≥1/10 HPF), ganglion-like cells, histological pattern I or II and relapse (≥4 times) was significantly associated with poor OS and EFS. IMT of the nasal cavity and paranasal sinuses exhibits relatively bland histologic appearances, but can shows strongly aggressive behavior and relatively poor outcomes. Multiple relapse, necrosis, frequent mitosis, the presence of ganglion-like cells, and histological pattern might be associated with poor clinical outcomes.
authors.affiliation: Department of Pathology, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang, Street. Dongcheng District, Beijing, 100730, China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: He
authors.affiliation: Department of Pathology, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang, Street. Dongcheng District, Beijing, 100730, China.
authors.forename: Ge-Hong
authors.initials: GH
authors.lastname: Dong
authors.affiliation: Department of Pathology, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang, Street. Dongcheng District, Beijing, 100730, China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Yang
authors.affiliation: Department of Pathology, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang, Street. Dongcheng District, Beijing, 100730, China. liuhg1125@163.com.
authors.forename: Hong-Gang
authors.initials: HG
authors.lastname: Liu
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D058628:Myofibroblasts / Q000473:pathology; D009296:Nasal Cavity / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010255:Paranasal Sinus Neoplasms / Q000473:pathology*; D010256:Paranasal Sinuses / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000473:pathology*
references.citation: Mod Pathol. 2001 Jun;14(6):569-76
references.pmid: 11406658
references.citation: AJNR Am J Neuroradiol. 1999 Jun-Jul;20(6):1133-9
references.pmid: 10445457
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Nov;112(5):684-7
references.pmid: 21868269
references.citation: J Int Med Res. 2009 May-Jun;37(3):867-77
references.pmid: 19589272
references.citation: J Clin Pathol. 2003 Sep;56(9):715-7
references.pmid: 12944561
references.citation: Mod Pathol. 1999 Mar;12(3):279-86
references.pmid: 10102613
references.citation: J Int Med Res. 2009 Nov-Dec;37(6):2000-8
references.pmid: 20146901
references.citation: Chin Med J (Engl). 2004 Oct;117(10):1597-9
references.pmid: 15498396
references.citation: Auris Nasus Larynx. 2007 Dec;34(4):533-6
references.pmid: 17331689
references.citation: Auris Nasus Larynx. 2010 Aug;37(4):526-9
references.pmid: 20053515
references.citation: Med Oncol. 2011 Dec;28 Suppl 1:S349-53
references.pmid: 21042957
references.citation: Am J Otolaryngol. 2006 Jul-Aug;27(4):275-7
references.pmid: 16798408
references.citation: Acta Otolaryngol. 2005 Mar;125(3):322-7
references.pmid: 15966706
references.citation: Int J Pediatr Otorhinolaryngol. 2001 Nov 1;61(2):161-5
references.pmid: 11589984
references.citation: Head Neck. 2005 Aug;27(8):722-8
references.pmid: 15880393
references.citation: Am J Surg Pathol. 1995 Aug;19(8):859-72
references.pmid: 7611533
references.citation: Am J Clin Pathol. 2003 Jul;120(1):56-61
references.pmid: 12866373
references.citation: Pathol Res Pract. 2011 May 15;207(5):322-6
references.pmid: 21371828
references.citation: Am J Surg Pathol. 2007 Apr;31(4):509-20
references.pmid: 17414097
references.citation: Med Mol Morphol. 2011 Sep;44(3):179-82
references.pmid: 21922391
references.citation: Am J Surg Pathol. 1991 Dec;15(12):1146-56
references.pmid: 1746682
references.citation: J Clin Pathol. 2008 Apr;61(4):428-37
references.pmid: 17938159
references.citation: Ear Nose Throat J. 2012 May;91(5):E1-3
references.pmid: 22614559
references.citation: J Formos Med Assoc. 2007 Feb;106(2):165-8
references.pmid: 17339162
references.citation: J Pediatr Surg. 2008 Dec;43(12):e35-7
references.pmid: 19040918
references.citation: Am J Surg Pathol. 2001 May;25(5):624-9
references.pmid: 11342774
references.citation: Childs Nerv Syst. 2009 Mar;25(3):285-91
references.pmid: 18830608
references.citation: AJR Am J Roentgenol. 1994 Sep;163(3):689-92
references.pmid: 8079869