title: Design, synthesis and bioactivity of N-glycosyl-N'-(5-substituted phenyl-2-furoyl) hydrazide derivatives.
abstract: Condensation products of 5-substituted phenyl-2-furoyl hydrazide with different monosaccharides D-glucose, D-galactose, D-mannose, D-fucose and D-arabinose were prepared. The anomerization and cyclic-acyclic isomers were investigated by 1H NMR spectroscopy. The results showed that, except for the d-glucose derivatives, which were in the presence of β-anomeric forms, all derivatives were in an acyclic Schiff base form. Their antifungal and antitumor activities were studied. The bioassay results indicated that some title compounds showed superior effects over the commercial positive controls.
authors.affiliation: Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China. ziningcui@scau.edu.cn.
authors.forename: Zining
authors.initials: Z
authors.lastname: Cui
authors.affiliation: Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China. kongkong_1989@sina.cn.
authors.forename: Hang
authors.initials: H
authors.lastname: Su
authors.affiliation: Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China. 97066h@cau.edu.cn.
authors.forename: Jiazhen
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China. yangxl@cau.edu.cn.
authors.forename: Xinling
authors.initials: X
authors.lastname: Yang
authors.affiliation: Division of Nanobiology, Advanced Integrated Science, Chiba University, Matsudo, Chiba 271-0092, Japan. ynishida@faculty.chiba-u.jp.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nishida
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009005:Monosaccharides / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D006835:Hydrazones; D009005:Monosaccharides; D012545:Schiff Bases
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