title: Lipid compartmentalization in the endosome system.
abstract: Lipids play an essential role in the structure of the endosomal membranes as well as in their dynamic rearrangement during the transport of internalized cargoes along the endocytic pathway. In this review, we discuss the function of endosomal lipids mainly in mammalian cells, focusing on two well-known components of the lipid rafts, sphingomyelin and cholesterol, as well as on three anionic phospholipids, phosphatidylserine, polyphosphoinositides and the atypical phospholipid, bis(monoacylglycero)phosphate/lysobisphosphatidic acid. We detail the structure, metabolism, distribution and role of these lipids in the endosome system as well as their importance in pathological conditions where modification of the endosomal membrane flow can lead to various diseases such as lipid-storage diseases, myopathies and neuropathies.
authors.affiliation: Lipid Biology Laboratory, RIKEN, 2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan; INSERM U1060-Université Lyon1, 69621 Villeurbanne, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Hullin-Matsuda
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Taguchi
authors.affiliation: Lipid Biology Laboratory, RIKEN, 2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan.
authors.forename: Peter
authors.initials: P
authors.lastname: Greimel
authors.affiliation: Lipid Biology Laboratory, RIKEN, 2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan; INSERM U1060-Université Lyon1, 69621 Villeurbanne, France. Electronic address: kobayasi@riken.jp.
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism*
chemical_list: D008563:Membrane Lipids
keywords: Bis(monoacylglycero)phosphate/lysobisphosphatidic acid; Cholesterol; Endocytosis; Phosphatidylserine; Polyphosphoinositides; Sphingomyelin