title: Protective effect of resveratrol on arsenic trioxide-induced nephrotoxicity in rats.
abstract: Arsenic, which causes human carcinogenicity, is ubiquitous in the environment. This study was designed to evaluate modulation of arsenic induced cancer by resveratrol, a phytoalexin found in vegetal dietary sources that has antioxidant and chemopreventive properties, in arsenic trioxide (As2O3)-induced Male Wistar rats.
  
  
  METHODS
  Adult rats received 3 mg/kg As2O3 (intravenous injection, iv.) on alternate days for 4 days. Resveratrol (8 mg/kg) was administered (iv.) 1 h before As2O3 treatment. The plasma and homogenization enzymes associated with oxidative stress of rat kidneys were measured, the kidneys were examined histologically and trace element contents were assessed.
  
  
  RESULTS
  Rats treated with As2O3 had significantly higher oxidative stress and kidney arsenic accumulation; however, pretreatment with resveratrol reversed these changes. In addition, prior to treatment with resveratrol resulted in lower blood urea nitrogen, creatinine and insignificant renal tubular epithelial cell necrosis. Furthermore, the presence of resveratrol preserved the selenium content (0.805 ± 0.059 µg/g) of kidneys in rats treated with As2O3. However, resveratrol had no effect on zinc level in the kidney relative to As2O3-treated groups.
  
  
  CONCLUSIONS
  Our data show that supplementation with resveratrol alleviated nephrotoxicity by improving antioxidant capacity and arsenic efflux. These findings suggest that resveratrol has the potential to protect against kidney damage in populations exposed to arsenic.
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Weiqian
authors.initials: W
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Inner Mongolia University for Nationalities, Tongliao 028000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ge
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Jing
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Huijie
authors.initials: H
authors.lastname: Jiang
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Yu
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhang
keywords: Arsenic; arsenic efflux; resveratrol; trace element
references.citation: Toxicology. 2005 Jul 1;211(1-2):26-35
references.pmid: 15863245
references.citation: Mol Nutr Food Res. 2012 Jan;56(1):7-13
references.pmid: 22218912
references.citation: Arch Toxicol. 2012 Jun;86(6):879-96
references.pmid: 22488045
references.citation: Chem Biol Interact. 1999 Aug 30;122(1):1-13
references.pmid: 10475611
references.citation: Drug Chem Toxicol. 2004 May;27(2):179-89
references.pmid: 15198077
references.citation: Arch Toxicol. 2001 Nov;75(9):531-7
references.pmid: 11760813
references.citation: Food Chem Toxicol. 2013 Jan;51:87-92
references.pmid: 23023136
references.citation: Evid Based Complement Alternat Med. 2012;2012:921430
references.pmid: 21826188
references.citation: Annu Rev Pharmacol Toxicol. 2012;52:37-56
references.pmid: 21819238
references.citation: Toxicol Sci. 2011 Oct;123(2):305-32
references.pmid: 21750349
references.citation: Nutr Res Pract. 2012 Aug;6(4):294-300
references.pmid: 22977682
references.citation: Nutr Res Pract. 2012 Dec;6(6):499-504
references.pmid: 23346299
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1246-52
references.pmid: 17548692
references.citation: Evid Based Complement Alternat Med. 2012;2012:479016
references.pmid: 23133495
references.citation: Toxicol Appl Pharmacol. 2007 Nov 1;224(3):274-83
references.pmid: 17306316
references.citation: Arch Toxicol. 2013 Jun;87(6):1025-35
references.pmid: 23471352
references.citation: Arch Toxicol. 2012 Mar;86(3):345-91
references.pmid: 22102161
references.citation: Clin Toxicol (Phila). 2006;44(2):135-41
references.pmid: 16615668
references.citation: Free Radic Biol Med. 2002 Aug 1;33(3):409-22
references.pmid: 12126763
references.citation: Nat Rev Drug Discov. 2006 Jun;5(6):493-506
references.pmid: 16732220
references.citation: Evid Based Complement Alternat Med. 2012;2012:606183
references.pmid: 23258992
references.citation: Biol Trace Elem Res. 2006 Winter;114(1-3):185-95
references.pmid: 17206001
references.citation: Exp Toxicol Pathol. 2010 Sep;62(5):543-7
references.pmid: 19674877
references.citation: Appl Environ Microbiol. 2008 May;74(9):2924-7
references.pmid: 18326684
references.citation: Toxicology. 2003 Apr 15;186(1-2):33-50
references.pmid: 12604169