title: The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane.
abstract: Indoleamine-2,3-dioxygenase-1 (IDO1) is a critical immunoregulatory enzyme responsible for the metabolism of tryptophan during inflammation and disease. Based upon a pyranonaphthoquinone framework, the first examples of indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing a carborane cage are reported. The novel closo-1,2-carboranyl-N-pyranonaphthoquinone derivatives display low μM binding affinity for the human recombinant enzyme, with IC50 values ranging from 0.78 to 1.77 μM.
authors.affiliation: School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. lou.rendina@sydney.edu.au.
authors.forename: Christopher J D
authors.initials: CJ
authors.lastname: Austin
authors.forename: Jan
authors.initials: J
authors.lastname: Kahlert
authors.forename: Fatiah
authors.initials: F
authors.lastname: Issa
authors.forename: John H
authors.initials: JH
authors.lastname: Reed
authors.forename: Jason R
authors.initials: JR
authors.lastname: Smith
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Ioppolo
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Ong
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Jamie
authors.forename: David
authors.initials: D
authors.lastname: Hibbs
authors.forename: Louis M
authors.initials: LM
authors.lastname: Rendina
mesh_terms: D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000037:antagonists & inhibitors*; D062105:Molecular Docking Simulation; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D001896:Boron Compounds; D004791:Enzyme Inhibitors; C576710:IDO1 protein, human; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D009285:Naphthoquinones