title: Inactivation of the prelimbic rather than infralimbic cortex impairs acquisition and expression of formalin-induced conditioned place avoidance.
abstract: Conditioned place avoidance (CPA) paradigm has been used to investigate the affective component of pain. Although the anterior cingulate cortex (ACC) has been demonstrated to play an important role in the affective aspect of pain, whether the other prefrontal subdivisions are involved in pain-related aversion is unknown. The present study investigated the role of the prelimbic cortex (PL) and infralimbic cortex (IL) in the acquisition and expression of formalin-induced CPA (F-CPA) in rats. GABAA receptor agonist muscimol was bilaterally microinjected into PL/IL before or after the formalin-paired training, to explore the effect of temporary inactivation of PL/IL on the acquisition and expression of F-CPA, respectively. The results showed that inactivation of PL rather than IL impaired the acquisition and expression of F-CPA. Moreover, the PL inactivation did not block the acquisition of LiCl-induced CPA, suggesting that PL may be specifically implicated in the pain-emotion related encoding. These results indicate that PL but not IL is involved in the aversive dimension of pain.
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100039, China.
authors.forename: Zhao-Cai
authors.initials: ZC
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Pan
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100039, China; Department of Psychology, Southwest University for Nationalities, Chengdu 610041, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100039, China.
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Deng
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, China. Electronic address: wangjy@psych.ac.cn.
authors.forename: Jin-Yan
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Luo
mesh_terms: D000818:Animals; D001362:Avoidance Learning; D003214:Conditioning, Classical / Q000187:drug effects*; D005557:Formaldehyde; D058785:GABA-A Receptor Agonists / Q000494:pharmacology; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology / Q000523:psychology*; D010147:Pain Measurement; D017397:Prefrontal Cortex / Q000503:physiopathology*; D017207:Rats, Sprague-Dawley
chemical_list: D058785:GABA-A Receptor Agonists; D005557:Formaldehyde; D009118:Muscimol
keywords: Acquisition; Conditioned place avoidance; Expression; Pain emotion; Prefrontal cortex; Rats
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