title: Unilateral exudative retinal detachment as the sole presentation of relapsing acute lymphoblastic leukemia.
abstract: Ocular findings are rarely the initial symptom of leukemia, although up to 90% of all leukemia patients have fundus changes during the course of the disease. Herein we report a relapsing acute lymphoblastic leukemia patient with thesole presentation of sudden visual loss and exudative retinal detachment. An 8-year-old boy with acute lymphoblasticleukemia developed sudden visual loss during his first remission period. Bullous retinal detachment with total afferentpupillary defect was observed. Orbital magnetic resonance imaging revealed an intraocular mass lesion; simultaneouslyobtained bone marrow and cerebrospinal fluid samples showed no evidence of leukemic cells. Following local irradiation,and systemic and intrathecal chemotherapy the mass disappeared. Local irradiation, and systemic and intrathecalchemotherapy effectively controlled the isolated ocular relapse of acute lymphoblastic leukemia and eliminated the needfor enucleation.
authors.affiliation: Diskapi Children's Hospital, Department of Pediatric Hematology, Ankara, Turkey.
authors.forename: Fatih Mehmet
authors.initials: FM
authors.lastname: Azık
authors.affiliation: Diskapi Children's Hospital, Department of Pediatric Hematology, Ankara, Turkey.
authors.forename: Arsen
authors.initials: A
authors.lastname: Akıncı
authors.affiliation: Diskapi Children's Hospital, Department of Pediatric Hematology, Ankara, Turkey.
authors.forename: Tülin Revide
authors.initials: TR
authors.lastname: Saylı
authors.affiliation: Diskapi Children's Hospital, Department of Pediatric Hematology, Ankara, Turkey.
authors.forename: Vildan Kosan
authors.initials: VK
authors.lastname: Culha
authors.affiliation: Ulucanlar Eye Hospital, Ankara, Turkey.
authors.forename: Kuddusi
authors.initials: K
authors.lastname: Teberik
authors.affiliation: Ulucanlar Eye Hospital, Ankara, Turkey.
authors.forename: Mehmet Yasin
authors.initials: MY
authors.lastname: Teke
authors.affiliation: Diskapi Children's Hospital, Department of Pediatric Hematology, Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Gürbüz
keywords: Acute lymphoblastic leukemia; Exudative retinal detachment; Relapse
references.citation: Retina. 1989;9(2):110-4
references.pmid: 2772418
references.citation: Arch Ophthalmol. 1961 Oct;66:490-508
references.pmid: 13860566
references.citation: Arch Ophthalmol. 1966 Jul;76(1):32-6
references.pmid: 5943674
references.citation: Blood. 2004 Nov 1;104(9):2690-6
references.pmid: 15251979
references.citation: Lancet. 1980 Mar 1;1(8166):452-3
references.pmid: 6102185
references.citation: Br J Ophthalmol. 1968 Oct;52(10):781-5
references.pmid: 5686969
references.citation: Med Pediatr Oncol. 1979;6(2):171-7
references.pmid: 287857
references.citation: J Pediatr Ophthalmol Strabismus. 2001 Jul-Aug;38(4):242-4
references.pmid: 11495313
references.citation: Arch Ophthalmol. 1988 Jan;106(1):21-2
references.pmid: 3422150
references.citation: J Pediatr Ophthalmol Strabismus. 1995 Jul-Aug;32(4):253-6
references.pmid: 7494164
references.citation: J Pediatr Ophthalmol Strabismus. 1981 May-Jun;18(3):42-4
references.pmid: 6943324
references.citation: Acta Ophthalmol (Copenh). 1988 Feb;66(1):33-7
references.pmid: 3259064
references.citation: Cancer. 1976 Oct;38(4):1744-9
references.pmid: 1068743