title: Fabrication of a multifunctional nano-in-micro drug delivery platform by microfluidic templated encapsulation of porous silicon in polymer matrix.
abstract: A multifunctional nano-in-micro drug delivery platform is developed by conjugating the porous silicon nanoparticles with mucoadhesive polymers and subsequent encapsulation into a pH-responsive polymer using microfluidics. The multistage platform shows monodisperse size distribution and pH-responsive payload release, and the released nanoparticles are mucoadhesive. Moreover, this platform is capable of simultaneously loading and releasing multidrugs with distinct properties.
authors.affiliation: Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Zhang
authors.forename: Dongfei
authors.initials: D
authors.lastname: Liu
authors.forename: Mohammad-Ali
authors.initials: MA
authors.lastname: Shahbazi
authors.forename: Ermei
authors.initials: E
authors.lastname: Mäkilä
authors.forename: Bárbara
authors.initials: B
authors.lastname: Herranz-Blanco
authors.forename: Jarno
authors.initials: J
authors.lastname: Salonen
authors.forename: Jouni
authors.initials: J
authors.lastname: Hirvonen
authors.forename: Hélder A
authors.initials: HA
authors.lastname: Santos
mesh_terms: D018938:Caco-2 Cells; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D016503:Drug Delivery Systems; D019073:HT29 Cells; D006801:Humans; D044085:Microfluidics; D008855:Microscopy, Electron, Scanning; D055616:Microtechnology; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology; D010316:Particle Size; D011108:Polymers; D016062:Porosity; D012825:Silicon
chemical_list: D011108:Polymers; D012825:Silicon
keywords: colon targeted drug delivery; microfluidics; mucoadhesion; pH-responsive microcomposite; porous silicon