title: Decreased saliva/serum irisin concentrations in the acute myocardial infarction promising for being a new candidate biomarker for diagnosis of this pathology.
abstract: Irisin is a muscle-secreted protein. Cardiac muscle produces more irisin than skeletal muscle in response to acute exercise, and is associated with myocardial infarction (MI) in an experimental model induced by isoproterenol in rats. The timing and significance of its release in patients with acute myocardial infarction (AMI) needs further investigation. We have studied the relationship between serum/saliva irisin concentration and AMI in humans. Serum and saliva samples were taken within 3 days of admission in 11 patients with AMI and in 14 matched controls. Salivary gland irisin was detected immunohistochemically, and serum and saliva levels were measured by ELISA. The three major paired salivary glands (submandibular, sublingual and parotid) produce and release irisin into saliva. Troponin-I, CK, CK-MB concentrations in the AMI group gradually increased from up to 12h, while saliva and serum irisin gradually decreased from up to 48 h, compared with the control group (P<0.05). After 12h, troponin-I, CK, CK-MB started to decrease, while saliva and serum irisin started to increase at 72 h. Serum irisin levels correlated with age, while troponin I, CK-MB, and CK were correlated and with saliva irisin in AMI patients. Besides cardiac troponin and CK-MB, irisin adds new diagnostic information in AMI patients, and the gradual decrease of saliva/serum irisin over 48 h could be a useful biomarker.
authors.affiliation: Department of Cardiovascular Surgery, Elazig Research and Education Hospital, Elazig 23100, Turkey; Firat University, School of Medicine, Department of Anatomy, Elazig 23119, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Aydin
authors.affiliation: Firat University, School of Medicine, Department of Medical Biochemistry (Firat Hormones Research Group), Elazig 23119, Turkey. Electronic address: saydin1@hotmail.com.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
authors.affiliation: Department of Cardiology, Elazig Research and Education Hospital, Elazig 23100, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Kobat
authors.affiliation: Laboratory of Medical Biochemistry, Elazig Research and Education Hospital, Elazig 23100, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kalayci
authors.affiliation: Dicle University, School of Medicine, Department of Cardiovascular Surgery, Diyarbakir 21280, Turkey.
authors.forename: Mehmet Nesimi
authors.initials: MN
authors.lastname: Eren
authors.affiliation: Firat University, School of Medicine, Department of Medical Biochemistry (Firat Hormones Research Group), Elazig 23119, Turkey.
authors.forename: Musa
authors.initials: M
authors.lastname: Yilmaz
authors.affiliation: Firat University, School of Medicine, Department of Histology and Embryology, Elazig 23119, Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Kuloglu
authors.affiliation: Department of Emergency, Elazig Research and Education Hospital, Elazig 23100, Turkey.
authors.forename: Evrim
authors.initials: E
authors.lastname: Gul
authors.affiliation: Department of Cardiology, Elazig Research and Education Hospital, Elazig 23100, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Secen
authors.affiliation: Department of Emergency, Elazig Research and Education Hospital, Elazig 23100, Turkey.
authors.forename: Omer Dogan
authors.initials: OD
authors.lastname: Alatas
authors.affiliation: Department of Cardiology, Elazig Research and Education Hospital, Elazig 23100, Turkey.
authors.forename: Adil
authors.initials: A
authors.lastname: Baydas
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood* / Q000378:metabolism*; D005260:Female; D005353:Fibronectins / Q000097:blood* / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism; D012463:Saliva / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C577593:FNDC5 protein, human; D005353:Fibronectins
keywords: Irisin; Myocardial infarction; Saliva; Serum