title: SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology.
abstract: Non-covalent (NP-1/3) and covalent (NP-A-1/3) pro-apoptotic SPION-Smac mimetic nano-conjugates antitumor agents are reported. The solution synthesis of key Smac mimetics, their support onto SPIONs through non-covalent adsorption (NP-1/3) or APTES-mediated covalent binding (NP-A-1/3), the analytical characterization of SPION-Smac mimetic conjugates, their target affinity in cell-free assays, and their cytotoxicity against tumor cells are thoroughly described.
authors.affiliation: Università degli Studi di Milano, Dipartimento di Chimica, Via Golgi 19, I-20133 Milan, Italy. Electronic address: pierfausto.seneci@unimi.it.
authors.forename: Pierfausto
authors.initials: P
authors.lastname: Seneci
authors.affiliation: Università degli Studi di Milano, Dipartimento di Chimica, Via Golgi 19, I-20133 Milan, Italy.
authors.forename: Mattia
authors.initials: M
authors.lastname: Rizzi
authors.affiliation: Università degli Studi di Milano, Dipartimento di Chimica, Via Golgi 19, I-20133 Milan, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Ballabio
authors.affiliation: Fondazione IRCCS Istituto Nazionale dei Tumori, Dipartimento di Oncologia Sperimentale e Medicina Molecolare, Via Amadeo 42, I-20133 Milan, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Lecis
authors.affiliation: Fondazione IRCCS Istituto Nazionale dei Tumori, Dipartimento di Oncologia Sperimentale e Medicina Molecolare, Via Amadeo 42, I-20133 Milan, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Conti
authors.affiliation: Università degli Studi di Milano, Dipartimento di Chimica, Via Golgi 19, I-20133 Milan, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Carrara
authors.affiliation: Università degli Studi di Milano, Dipartimento di Chimica, Via Golgi 19, I-20133 Milan, Italy. Electronic address: emanuela.licandro@unimi.it.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Licandro
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D003911:Dextrans / Q000737:chemistry* / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D024101:Mitochondrial Proteins / Q000737:chemistry*; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D011485:Protein Binding
chemical_list: D000970:Antineoplastic Agents; D051017:Apoptosis Regulatory Proteins; C412403:DIABLO protein, human; D003911:Dextrans; D047908:Intracellular Signaling Peptides and Proteins; D058185:Magnetite Nanoparticles; D024101:Mitochondrial Proteins; C097921:ferumoxtran-10
keywords: Oncology; Peptidomimetics; Pro-apoptotics; SPION nanoparticles; Smac mimetics