title: Crevicular and serum levels of monocyte chemoattractant protein-4 and high-sensitivity C-reactive protein in periodontal health and disease.
abstract: OBJECTIVE
  Chemokines are chemotactic cytokines that are involved in destruction of the periodontal structures. The aim of this study is to determine the presence of MCP-4 and high sensitivity C reactive protein (hsCRP) levels in gingival crevicular fluid (GCF) and serum in periodontal health and disease and to find a correlation between MCP-4 and hsCRP in GCF and serum.
  
  
  METHODS
  40 subjects (20 males and 20 females) were selected and divided into three groups based on clinical parameters and radiologic parameters: Group 1 (10 healthy); Group 2 (15 gingivitis subjects) and Group 3 (15 chronic periodontitis subjects). The levels of serum and GCF MCP-4 were determined by ELISA and hsCRP levels were determined by immunoturbidimetry method.
  
  
  RESULTS
  The mean GCF and serum concentration of MCP-4 were the highest for group 3 followed by group 2 and least in group 1. Similarly, the mean hsCRP concentrations were highest for group 3 and least in group 1. Moreover, a significant positive correlation was found between serum and GCF MCP-4 and hsCRP levels and periodontal parameters.
  
  
  CONCLUSIONS
  The levels of MCP-4 and hsCRP increased from healthy to periodontitis. It can be proposed that MCP-4 and hsCRP are the potential biomarkers of inflammation in periodontal health and disease.
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore 560002, Karnataka, India.
authors.forename: Minal
authors.initials: M
authors.lastname: Kumari
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore 560002, Karnataka, India. Electronic address: periodonticsgdcri@gmail.com.
authors.forename: A R
authors.initials: AR
authors.lastname: Pradeep
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore 560002, Karnataka, India.
authors.forename: N
authors.initials: N
authors.lastname: Priyanka
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore 560002, Karnataka, India.
authors.forename: Nitish
authors.initials: N
authors.lastname: Kalra
authors.affiliation: Department of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bangalore 560002, Karnataka, India.
authors.forename: Savitha B
authors.initials: SB
authors.lastname: Naik
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D055113:Chronic Periodontitis / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D008297:Male; D018945:Monocyte Chemoattractant Proteins / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D018945:Monocyte Chemoattractant Proteins; D002097:C-Reactive Protein
keywords: C-reactive protein; Chronic periodontitis; Monocyte chemoattractant protein