title: [A case of bisphosphonate-related osteonecrosis of the jaw in a patient who had received intravenous bisphosphonates].
abstract: Bisphosphonates(BPs)have been widely used for the treatment of hypercalcemia associated with cancer, multiple myeloma bone diseases, and bone metastasis of solid cancers. Many cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ)have been reported in Japan. We report a case of a patient who developed BRONJ after tooth extraction even though the administration of BPs had been discontinued for 23 months. The patient was a 74-year-old woman who had received intravenous BPs from 2003 through 2008. She underwent tooth extraction in 2010. The bone in the extraction socket was exposed for more than 8 weeks. A clinical diagnosis of BRONJ was made. Discontinuation of BPs before surgical dental treatment did not appear to prevent BRONJ in this patient who had received intravenous BPs.
authors.affiliation: Division of Head and Neck Surgery, Shikoku Cancer Center.
authors.forename: Tohru
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000175:diagnosis* / Q000209:etiology; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D014081:Tooth Extraction / Q000009:adverse effects*
chemical_list: D004164:Diphosphonates