title: Biological evaluation of quaternary bis ammonium salt and cetylpyridinum bromide against S. epidermidis biofilm.
abstract: Quaternary ammonium compounds are broad-spectrum bacteriocides widely used as antiseptics, disinfection and preservation agents. The aim of this study was to examine the activity of two quaternary ammonium salts, cetylpyridinum bromide and a newly synthesized quaternary bis ammonium salt, against S. epidermidis biofilm. The average values of killing efficiency for cetylpyridinum bromide ranged from 26.6% to 64.1% for all tested concentrations (0.125 to 8.0 microg x mL(-1)) and for quaternary bis ammonium salt the percentage of killing efficiency ranged from 59.7% to 88.4% for tested concentrations (from 2.0 to 128.0 microg x mL(-1)). Both tested compounds significantly affect staphylococcal biofilms, but any of used concentrations caused a total eradication of bacterial biofilm.
authors.forename: Joanna
authors.initials: J
authors.lastname: Stefańska
authors.forename: Anna
authors.initials: A
authors.lastname: Pietruczuk-Padzik
authors.forename: Marta
authors.initials: M
authors.lastname: Struga
authors.forename: Maciej
authors.initials: M
authors.lastname: Borkowski
authors.forename: Stefan
authors.initials: S
authors.lastname: Tyski
mesh_terms: D000473:Alkanes / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002594:Cetylpyridinium / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000502:physiology*
chemical_list: D000473:Alkanes; D004202:Disinfectants; D000644:Quaternary Ammonium Compounds; C413608:quaternary bisammonium salt; D002594:Cetylpyridinium