title: Immature visual neural system in children reflected by contrast sensitivity with adaptive optics correction.
abstract: This study aimed to explore the neural development status of the visual system of children (around 8 years old) using contrast sensitivity. We achieved this by eliminating the influence of higher order aberrations (HOAs) with adaptive optics correction. We measured HOAs, modulation transfer functions (MTFs) and contrast sensitivity functions (CSFs) of six children and five adults with both corrected and uncorrected HOAs. We found that when HOAs were corrected, children and adults both showed improvements in MTF and CSF. However, the CSF of children was still lower than the adult level, indicating the difference in contrast sensitivity between groups cannot be explained by differences in optical factors. Further study showed that the difference between the groups also could not be explained by differences in non-visual factors. With these results we concluded that the neural systems underlying vision in children of around 8 years old are still immature in contrast sensitivity.
authors.affiliation: CAS Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Zhou
authors.affiliation: 1] Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu, China [2] The Key Laboratory on Adaptive Optics, Chinese Academy of Sciences, Chengdu 610209, China.
authors.forename: Haoxin
authors.initials: H
authors.lastname: Zhao
authors.affiliation: 1] Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu, China [2] The Key Laboratory on Adaptive Optics, Chinese Academy of Sciences, Chengdu 610209, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Dai
authors.affiliation: 1] Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu, China [2] The Key Laboratory on Adaptive Optics, Chinese Academy of Sciences, Chengdu 610209, China.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: CAS Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
authors.affiliation: CAS Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000328:Adult; D002648:Child; D015350:Contrast Sensitivity / Q000502:physiology*; D005123:Eye / Q000294:innervation*; D005139:Eyeglasses; D005260:Female; D006801:Humans; D008297:Male; D055620:Optical Phenomena; D014785:Vision, Ocular / Q000502:physiology*
references.citation: Vision Res. 1998 Jul;38(14):2211-8
references.pmid: 9797980
references.citation: Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6692-7
references.pmid: 15096608
references.citation: Invest Ophthalmol Vis Sci. 1984 Nov;25(11):1307-15
references.pmid: 6490332
references.citation: J Opt Soc Am A Opt Image Sci Vis. 1998 Sep;15(9):2536-44
references.pmid: 9729866
references.citation: Am J Ophthalmol. 2004 Jun;137(6):988-92
references.pmid: 15183781
references.citation: J Vis. 2003;3(10):630-41
references.pmid: 14640887
references.citation: J Opt Soc Am A Opt Image Sci Vis. 2001 Aug;18(8):1793-803
references.pmid: 11488483
references.citation: Invest Ophthalmol Vis Sci. 2003 Jul;44(7):3248-56
references.pmid: 12824277
references.citation: Acta Ophthalmol. 2011 May;89(3):278-83
references.pmid: 19909292
references.citation: J Cataract Refract Surg. 2003 Aug;29(8):1514-21
references.pmid: 12954298
references.citation: J Physiol. 1966 Oct;186(3):558-78
references.pmid: 5972153
references.citation: Optom Vis Sci. 2003 Jan;80(1):43-9
references.pmid: 12553543
references.citation: Vision Res. 2009 Oct;49(21):2599-603
references.pmid: 19622368
references.citation: J Physiol. 1965 Dec;181(3):576-93
references.pmid: 5880378
references.citation: Br J Ophthalmol. 1980 Nov;64(11):863-6
references.pmid: 7426558
references.citation: Ophthalmic Physiol Opt. 1987;7(1):21-30
references.pmid: 3658420
references.citation: Child Dev. 1989 Jun;60(3):611-24
references.pmid: 2737011
references.citation: Clin Exp Optom. 2011 Mar;94(2):223-9
references.pmid: 21083759
references.citation: Vision Res. 2006 Apr;46(8-9):1210-20
references.pmid: 16005931
references.citation: J Opt Soc Am A Opt Image Sci Vis. 2002 Feb;19(2):266-75
references.pmid: 11822589
references.citation: Sci Rep. 2012;2:364
references.pmid: 22509464
references.citation: Neurosci Lett. 2003 Jul 24;345(3):161-4
references.pmid: 12842281
references.citation: J Neurosci. 2005 Mar 9;25(10):2712-22
references.pmid: 15758181
references.citation: Optom Vis Sci. 1997 Oct;74(10):785-9
references.pmid: 9383792
references.citation: J Refract Surg. 2000 Sep-Oct;16(5):S554-9
references.pmid: 11019871
references.citation: Vision Res. 1999 Jul;39(14):2325-33
references.pmid: 10367054
references.citation: Vision Res. 2002 Apr;42(8):1063-70
references.pmid: 11934456
references.citation: Vision Res. 1982;22(8):953-9
references.pmid: 7135857
references.citation: Invest Ophthalmol Vis Sci. 1981 Nov;21(5):737-44
references.pmid: 7298276
references.citation: J Cataract Refract Surg. 2009 Dec;35(12):2144-8
references.pmid: 19969221
references.citation: Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):4068-73
references.pmid: 18316716
references.citation: J Cataract Refract Surg. 2006 Jan;32(1):78-84
references.pmid: 16516783
references.citation: Optom Vis Sci. 2009 Jul;86(7):868-74
references.pmid: 19521271
references.citation: Clin Exp Optom. 2012 Jul;95(4):399-403
references.pmid: 22640028
references.citation: J Opt Soc Am A Opt Image Sci Vis. 2001 Mar;18(3):497-506
references.pmid: 11265680
references.citation: Ophthalmic Physiol Opt. 2008 Nov;28(6):532-7
references.pmid: 19076555
references.citation: Ophthalmic Physiol Opt. 2002 Mar;22(2):103-12
references.pmid: 12014483
references.citation: Ophthalmic Physiol Opt. 2000 Jul;20(4):323-34
references.pmid: 10962698
references.citation: Ophthalmology. 2006 Oct;113(10):1807-12
references.pmid: 16876865
references.citation: Vision Res. 2000;40(10-12):1203-15
references.pmid: 10788636
references.citation: Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1334-8
references.pmid: 16565365
references.citation: J Neurosci Methods. 2003 Nov 30;130(1):9-18
references.pmid: 14583400
references.citation: J Opt Soc Am A Opt Image Sci Vis. 2007 Mar;24(3):578-87
references.pmid: 17301847
references.citation: J Vis. 2011 Jun 16;11(7):
references.pmid: 21680646
references.citation: Vision Res. 2002 Apr;42(9):1205-10
references.pmid: 11997058
references.citation: J Exp Child Psychol. 2010 Dec;107(4):423-37
references.pmid: 20633893
references.citation: J Vis. 2009 Feb 27;9(2):24.1-16
references.pmid: 19271934
references.citation: Invest Ophthalmol Vis Sci. 1987 Mar;28(3):607-12
references.pmid: 3549615
references.citation: J Opt Soc Am A Opt Image Sci Vis. 1997 Nov;14(11):2873-83
references.pmid: 9379245
references.citation: Optom Vis Sci. 2004 Apr;81(4):245-54
references.pmid: 15097766
references.citation: Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5438-46
references.pmid: 14638749
references.citation: Invest Ophthalmol Vis Sci. 2010 Jan;51(1):614-22
references.pmid: 19684002
references.citation: J Vis. 2009 Jan 15;9(1):16.1-14
references.pmid: 19271886
references.citation: Neurosci Lett. 2010 Mar 26;472(3):175-8
references.pmid: 20138967