title: From promotion to management: the wide impact of bacteria on cancer and its treatment.
abstract: In humans, the intestine is the major reservoir of microbes. Although the intestinal microbial community exists in a state of homeostasis called eubiosis, environmental and genetics factors can lead to microbial perturbation or dysbiosis, a state associated with various pathologies including inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Dysbiotic microbiota is thought to contribute to the initiation and progression of CRC. At the opposite end of the spectrum, two recently published studies in Science reveal that the microbiota is essential for chemotherapeutic drug efficacy, suggesting a beneficial microbial function in cancer management. The dichotomy between the beneficial and detrimental roles of the microbiota during cancer initiation, progression, and treatment emphasize the interwoven relationship between bacteria and cancer. Moreover, these findings suggest that the microbiota could be considered as a therapeutic target, not only at the level of cancer prevention, but also during management, i.e. by enhancing the efficacy of chemotherapeutics.
authors.affiliation: Department of Medicine and Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL, USA; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Perez-Chanona
authors.forename: Christian
authors.initials: C
authors.lastname: Jobin
mesh_terms: D000818:Animals; D007422:Intestines / Q000382:microbiology*; D064307:Microbiota / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D059016:Tumor Microenvironment / Q000276:immunology*
keywords: cancer; chemotherapy; dysbiosis; intestinal microbiota; therapeutic efficacy
references.citation: Gut. 2014 May;63(5):761-70
references.pmid: 23846483
references.citation: J Med Microbiol. 2013 Aug;62(Pt 8):1107-1123
references.pmid: 23558140
references.citation: Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4554-61
references.pmid: 20847294
references.citation: Appl Microbiol Biotechnol. 2013 Jun;97(12):5189-99
references.pmid: 23644748
references.citation: PLoS One. 2013;8(2):e56964
references.pmid: 23457644
references.citation: Eur J Cancer. 2013 Dec;49(18):3813-20
references.pmid: 24011937
references.citation: Sci Rep. 2013 Oct 08;3:2868
references.pmid: 24100376
references.citation: Biol Rev Camb Philos Soc. 2012 Aug;87(3):701-30
references.pmid: 22296522
references.citation: Cancer Discov. 2013 Apr;3(4):384-7
references.pmid: 23580283
references.citation: PLoS One. 2013;8(1):e53653
references.pmid: 23335968
references.citation: mBio. 2013 Nov 05;4(6):e00692-13
references.pmid: 24194538
references.citation: Cell Host Microbe. 2013 Aug 14;14(2):207-15
references.pmid: 23954159
references.citation: J Bacteriol. 2013 Dec;195(24):5567-76
references.pmid: 24123819
references.citation: Nat Rev Cancer. 2013 Nov;13(11):800-12
references.pmid: 24132111
references.citation: Cancer Lett. 2011 Oct 28;309(2):119-27
references.pmid: 21741763
references.citation: Science. 2013 Nov 22;342(6161):967-70
references.pmid: 24264989
references.citation: Appl Environ Microbiol. 2012 Nov;78(21):7603-10
references.pmid: 22923405
references.citation: Nature. 2012 Jun 13;486(7402):207-14
references.pmid: 22699609
references.citation: Cell Host Microbe. 2013 Aug 14;14(2):195-206
references.pmid: 23954158
references.citation: J Clin Invest. 2013 Feb;123(2):700-11
references.pmid: 23281400
references.citation: Nat Rev Microbiol. 2013 Apr;11(4):227-38
references.pmid: 23435359
references.citation: Bioessays. 2013 Oct;35(10):913-23
references.pmid: 23946088
references.citation: Science. 2013 Aug 2;341(6145):569-73
references.pmid: 23828891
references.citation: Bioessays. 2011 Aug;33(8):574-81
references.pmid: 21732396
references.citation: Gastroenterology. 2013 Jun;144(7):1394-401, 1401.e1-4
references.pmid: 23474283
references.citation: Sci Transl Med. 2012 Jun 6;4(137):137rv6
references.pmid: 22674556
references.citation: Nature. 2013 Dec 19;504(7480):451-5
references.pmid: 24226773
references.citation: Cold Spring Harb Perspect Med. 2013 Mar 01;3(3):a010074
references.pmid: 23457295
references.citation: Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204-9
references.pmid: 20566854
references.citation: Semin Immunopathol. 2011 Jul;33(4):369-83
references.pmid: 21611872
references.citation: Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4607-14
references.pmid: 20826446
references.citation: Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4578-85
references.pmid: 20668239
references.citation: Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10462-7
references.pmid: 22689992
references.citation: Science. 2013 Nov 22;342(6161):971-6
references.pmid: 24264990
references.citation: Am J Physiol Gastrointest Liver Physiol. 2011 Dec;301(6):G1020-30
references.pmid: 21903760
references.citation: Genome Res. 2012 Feb;22(2):292-8
references.pmid: 22009990
references.citation: Genome Biol. 2012 Apr 16;13(9):R79
references.pmid: 23013615
references.citation: Cell. 2013 Dec 19;155(7):1451-63
references.pmid: 24315484
references.citation: Immunity. 2014 Jan 16;40(1):128-39
references.pmid: 24412617
references.citation: Gastroenterology. 2004 Jul;127(1):80-93
references.pmid: 15236175
references.citation: Science. 2012 Oct 5;338(6103):120-3
references.pmid: 22903521
references.citation: Bioessays. 2013 Sep;35(9):810-7
references.pmid: 23836415
references.citation: Nature. 2013 Dec 19;504(7480):446-50
references.pmid: 24226770
references.citation: Oncol Lett. 2014 Feb;7(2):576-582
references.pmid: 24396491