title: Prostate cancer: preventing metastasis to bone: is this the end of the story?
abstract: A new report of zoledronic acid in men with high-risk prostate cancer is the latest in a long line of negative studies that have addressed the prevention of metastasis. We must learn from these studies so that potentially useful agents are not discarded due to poor trial design in the future.
authors.affiliation: Centre Hospitalier de I'Université de Montréal, Urology Division, Hôpital Notre-Dame, 1560 Sherbrooke Rast, Montreal, QC H2L 4M1, Canada.
authors.forename: Fred
authors.initials: F
authors.lastname: Saad
mesh_terms: D001859:Bone Neoplasms / Q000517:prevention & control / Q000556:secondary*; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D009362:Neoplasm Metastasis / Q000517:prevention & control; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017211:Treatment Failure; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid
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