title: Network-based study reveals potential infection pathways of hepatitis-C leading to various diseases.
abstract: Protein-protein interaction network-based study of viral pathogenesis has been gaining popularity among computational biologists in recent days. In the present study we attempt to investigate the possible pathways of hepatitis-C virus (HCV) infection by integrating the HCV-human interaction network, human protein interactome and human genetic disease association network. We have proposed quasi-biclique and quasi-clique mining algorithms to integrate these three networks to identify infection gateway host proteins and possible pathways of HCV pathogenesis leading to various diseases. Integrated study of three networks, namely HCV-human interaction network, human protein interaction network, and human proteins-disease association network reveals potential pathways of infection by the HCV that lead to various diseases including cancers. The gateway proteins have been found to be biologically coherent and have high degrees in human interactome compared to the other virus-targeted proteins. The analyses done in this study provide possible targets for more effective anti-hepatitis-C therapeutic involvement.
authors.affiliation: Department of Computer Science and Engineering, University of Kalyani, Kalyani, West Bengal, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Mukhopadhyay
authors.affiliation: Department of Computer Science and Engineering, Jadavpur University, Kolkata, West Bengal, India.
authors.forename: Ujjwal
authors.initials: U
authors.lastname: Maulik
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D057225:Data Mining; D030562:Databases, Protein; D063990:Gene Ontology; D016174:Hepacivirus / Q000378:metabolism / Q000502:physiology*; D006526:Hepatitis C / Q000378:metabolism*; D006801:Humans; D060066:Protein Interaction Maps; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D014764:Viral Proteins
references.citation: Mol Biosyst. 2010 Dec;6(12):2539-53
references.pmid: 20953506
references.citation: J Hepatol. 2011 Aug;55(2):289-98
references.pmid: 21147189
references.citation: J Glob Infect Dis. 2009 Jan;1(1):33-7
references.pmid: 20300384
references.citation: Virol J. 2011 Nov 01;8:496
references.pmid: 22044490
references.citation: BMC Med Genomics. 2010 Jan 21;3:1
references.pmid: 20092628
references.citation: Nature. 2002 Jan 10;415(6868):141-7
references.pmid: 11805826
references.citation: Mol Biosyst. 2011 Jun;7(6):1842-51
references.pmid: 21437347
references.citation: Gastroenterology. 2008 Jun;134(7):2144-52
references.pmid: 18549882
references.citation: BMC Med Genomics. 2011 Aug 08;4:62
references.pmid: 21824427
references.citation: PLoS Pathog. 2011 Feb 10;7(2):e1001278
references.pmid: 21347350
references.citation: Infect Genet Evol. 2011 Dec;11(8):1971-7
references.pmid: 21930248
references.citation: PLoS One. 2011;6(8):e23856
references.pmid: 21886832
references.citation: Arthritis Res Ther. 2012 Jun 25;14(3):215
references.pmid: 22731694
references.citation: Nat Rev Drug Discov. 2004 Apr;3(4):301-17
references.pmid: 15060526
references.citation: Diabet Med. 2005 Mar;22(3):340-3
references.pmid: 15717885
references.citation: PLoS Comput Biol. 2010 Jul 29;6(7):e1000863
references.pmid: 20686668
references.citation: Cell. 2005 Sep 23;122(6):957-68
references.pmid: 16169070
references.citation: BMC Bioinformatics. 2014 Jan 24;15:26
references.pmid: 24460683
references.citation: J Med Virol. 1997 Oct;53(2):182-4
references.pmid: 9334931
references.citation: Nature. 2000 Feb 10;403(6770):623-7
references.pmid: 10688190
references.citation: Dig Liver Dis. 2012 May;44(5):406-12
references.pmid: 22245505
references.citation: PPAR Res. 2009;2009:483485
references.pmid: 19132131
references.citation: Acta Derm Venereol. 1995 Nov;75(6):482-3
references.pmid: 8651030
references.citation: Nature. 2002 Jan 10;415(6868):180-3
references.pmid: 11805837
references.citation: J Virol. 2009 Mar;83(5):2389-92
references.pmid: 19091860
references.citation: Inflamm Bowel Dis. 2010 Jun;16(6):925-32
references.pmid: 20480515
references.citation: PLoS One. 2012;7(4):e32289
references.pmid: 22539940
references.citation: Clin Infect Dis. 2009 Jul 15;49(2):225-32
references.pmid: 19508169
references.citation: World J Gastroenterol. 2005 Mar 28;11(12):1843-7
references.pmid: 15793878
references.citation: Clin Epidemiol. 2010 Aug 09;2:179-86
references.pmid: 20865115
references.citation: J Korean Med Sci. 2011 Dec;26(12):1638-41
references.pmid: 22148004
references.citation: Pac Symp Biocomput. 2009;:516-27
references.pmid: 19209727
references.citation: Am J Hematol. 2010 Feb;85(2):106-10
references.pmid: 20095034
references.citation: J Rheumatol. 2003 Jul;30(7):1473-8
references.pmid: 12858443
references.citation: J Gen Virol. 2009 May;90(Pt 5):1071-1080
references.pmid: 19264595
references.citation: Viruses. 2010 Aug;2(8):1635-46
references.pmid: 21994698
references.citation: BMC Cancer. 2011 Nov 24;11:495
references.pmid: 22115285
references.citation: Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13396-401
references.pmid: 9391035
references.citation: Mol Syst Biol. 2008;4:230
references.pmid: 18985028
references.citation: Clin Gastroenterol Hepatol. 2009 Aug;7(8):894-9
references.pmid: 19558999
references.citation: N Engl J Med. 2003 Apr 24;348(17):1625-38
references.pmid: 12711737
references.citation: Nature. 2005 Oct 20;437(7062):1173-8
references.pmid: 16189514
references.citation: Hepatology. 2009 Jan;49(1):116-23
references.pmid: 19085911
references.citation: Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4569-74
references.pmid: 11283351
references.citation: PLoS One. 2011 Jan 10;6(1):e16034
references.pmid: 21249226
references.citation: Digestion. 2006;73(4):210-4
references.pmid: 16883071