title: Pulse oximeter oxygen saturation in prediction of arterial oxygen saturation in liver transplant candidates.
abstract: BACKGROUND
  Liver transplant is the only definitive treatment for many patients with end stage liver disease. Presence and severity of preoperative pulmonary disease directly affect the rate of postoperative complications of the liver transplantation. Arterial blood gas (ABG) measurement, performed in many transplant centers, is considered as a traditional method to diagnose hypoxemia. Because ABG measurement is invasive and painful, pulse oximetry, a bedside, noninvasive and inexpensive technique, has been recommended as an alternative source for the ABG measurement.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the efficacy of pulse oximetry as a screening tool in hypoxemia detection in liver transplant candidates and to compare the results with ABGs.
  
  
  METHODS
  Three hundred and ninety transplant candidates (237 males and 153 females) participated in this study. Arterial blood gas oxyhemoglobin saturation (SaO2) was recorded and compared with pulse oximetry oxyhemoglobin saturation (SpO2) results for each participants. The area under the curve (AUC) of receiver operating characteristic (ROC) curves was calculated by means of nonparametric methods to evaluate the efficacy of pulse oximetry to detect hypoxemia.
  
  
  RESULTS
  Roc-derived SpO2 threshold of ≤ 94% can predict hypoxemia (PaO2 < 60 mmHg) with a sensitivity of 100% and a specificity of 95%. Furthermore, there are associations between the ROC-derived SpO2 threshold of ≤ 97% and detection of hypoxemia (PaO2 < 70 mmHg) with a sensitivity of 100% and a specificity of 46%. The accuracy of pulse oximetry was not affected by the severity of liver disease in detection of hypoxemia.
  
  
  CONCLUSIONS
  Provided that SpO2 is equal to or greater than 94%, attained from pulse oximetry can be used as a reliable and accurate substitute for the ABG measurements to evaluate hypoxemia in patients with end stage liver disease.
authors.affiliation: Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Seiyed Mohammad Ali
authors.initials: SM
authors.lastname: Ghayumi
authors.affiliation: Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Khalafi-Nezhad
authors.affiliation: Department of Operative Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Jowkar
keywords: Blood Gas Monitoring, Transcutaneous; Liver Cirrhosis; Liver Transplantation; Oximetry; hypoxemia
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