title: Effect of hypoxic training on inflammatory and metabolic risk factors: a crossover study in healthy subjects.
abstract: The purpose of this study was to investigate the influence of hypoxic physical exercise on metabolic syndrome (MS) risk markers and high-sensitivity C-reactive protein (CRP) and to compare its effects on preperitoneal fat, arterial stiffness, and several blood parameters related to MS to those of a control group who trained under normoxic conditions. Fourteen healthy men were examined. Participants performed treadmill exercise 3 days per week for 4 weeks, under either normobaric hypoxic or normobaric normoxic conditions, for 50 min (including a 5-min warm-up and 5-min cool down) after a 30-min rest period. Exercise was performed at a heart rate (HR) corresponding to 60% of the HR at each individual's maximum oxygen uptake. Training under the different environmental conditions was performed 4 months apart to ensure a sufficient washout period. Waist circumference, preperitoneal fat thickness, brachial-ankle pulse wave velocity, and high-sensitivity CRP after training were significantly lower in the hypoxic group than in the normoxic group. Our results suggest that regular short-term hypoxic training may more effectively reduce arterial stiffness, and thus prevent arteriosclerosis, compared to training performed at a similar exercise intensity under normoxic conditions.
authors.affiliation: Department of Sports Medicine and Sports Science, Gifu University Graduate School of Medicine, 1-1, Yanagido, Gifu, 501-1194, Japan.
authors.forename: Bateer
authors.initials: B
authors.lastname: Shi
authors.affiliation: Department of Sports Medicine and Sports Science, Gifu University Graduate School of Medicine, 1-1, Yanagido, Gifu, 501-1194, Japan.
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Department of Sports Medicine and Sports Science, Gifu University Graduate School of Medicine, 1-1, Yanagido, Gifu, 501-1194, Japan.
authors.forename: Sohee
authors.initials: S
authors.lastname: Shin
authors.affiliation: Department of Sports Medicine and Sports Science, Gifu University Graduate School of Medicine, 1-1, Yanagido, Gifu, 501-1194, Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Yabumoto
authors.affiliation: Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, 1-1, Yanagido, Gifu, 501-1194, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Takemura
authors.affiliation: Department of Sports Medicine and Sports Science, Gifu University Graduate School of Medicine, 1-1, Yanagido, Gifu, 501-1194, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Matsuoka
keywords: Arterial stiffness; high‐sensitivity C‐reactive protein; metabolic syndrome; pulse wave velocity
references.citation: Nutr Rev. 2013 Mar;71(3):168-79
references.pmid: 23452284
references.citation: Intern Med. 2011;50(5):389-95
references.pmid: 21372447
references.citation: J Am Coll Cardiol. 2002 Jan 16;39(2):257-65
references.pmid: 11788217
references.citation: Metabolism. 2002 Aug;51(8):1034-40
references.pmid: 12145778
references.citation: Vasc Health Risk Manag. 2006;2(2):145-52
references.pmid: 17319458
references.citation: J Biol Chem. 2000 May 5;275(18):13613-20
references.pmid: 10788478
references.citation: Circulation. 2009 Oct 20;120(16):1640-5
references.pmid: 19805654
references.citation: Hypertension. 1998 Sep;32(3):565-9
references.pmid: 9740627
references.citation: Circulation. 1999 Sep 28;100(13):1481-92
references.pmid: 10500053
references.citation: Eur J Appl Physiol. 2013 Feb;113(2):349-57
references.pmid: 22729610
references.citation: Obesity (Silver Spring). 2010 Jan;18(1):116-20
references.pmid: 19543214
references.citation: J Appl Physiol (1985). 2005 Apr;98(4):1154-62
references.pmid: 15772055
references.citation: Hypertens Res. 2002 May;25(3):359-64
references.pmid: 12135313
references.citation: Int J Sports Med. 2000 Jan;21(1):21-4
references.pmid: 10683094
references.citation: J Appl Physiol (1985). 2007 Jan;102(1):79-86
references.pmid: 16990498
references.citation: J Physiol Sci. 2011 Mar;61(2):83-91
references.pmid: 21181322
references.citation: Ann Med. 2006;38(1):34-41
references.pmid: 16448987
references.citation: Stroke. 2001 Feb;32(2):454-60
references.pmid: 11157182
references.citation: Front Pharmacol. 2012 Jul 19;3:119
references.pmid: 22833723
references.citation: Am Heart J. 1999 Nov;138(5 Pt 2):S419-20
references.pmid: 10539839
references.citation: Circ J. 2008 Dec;72(12):2046-50
references.pmid: 18946171
references.citation: Am J Respir Cell Mol Biol. 1996 Jul;15(1):9-19
references.pmid: 8679227
references.citation: Indian Heart J. 1990 Sep-Oct;42(5):375-9
references.pmid: 2086444
references.citation: Chin Med J (Engl). 2006 Nov 20;119(22):1866-70
references.pmid: 17134584
references.citation: J Appl Physiol (1985). 2006 Apr;100(4):1238-48
references.pmid: 16540709
references.citation: Atherosclerosis. 2012 Jan;220(1):215-8
references.pmid: 22035573
references.citation: Pharmacol Rev. 2008 Mar;60(1):79-127
references.pmid: 18323402
references.citation: Int J Prev Med. 2012 Sep;3(9):652-9
references.pmid: 23024855
references.citation: J Atheroscler Thromb. 2004;11(3):173-9
references.pmid: 15256769
references.citation: Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1868-73
references.pmid: 15284086
references.citation: Eur J Appl Physiol. 2003 Jan;88(4-5):396-403
references.pmid: 12527969
references.citation: J Am Coll Cardiol. 2004 Dec 21;44(12):2411-3
references.pmid: 15607408
references.citation: Int J Cardiol. 2013 Sep 20;168(1):375-81
references.pmid: 23041100
references.citation: Chest. 2014 Mar 1;145(3):542-550
references.pmid: 24091482
references.citation: J Clin Endocrinol Metab. 1996 Dec;81(12):4433-8
references.pmid: 8954055
references.citation: Behav Res Methods. 2007 May;39(2):175-91
references.pmid: 17695343
references.citation: Circulation. 1989 Jul;80(1):78-86
references.pmid: 2610739
references.citation: Sleep Breath. 2008 May;12(2):129-34
references.pmid: 18057976
references.citation: Circulation. 2002 Mar 5;105(9):1135-43
references.pmid: 11877368
references.citation: Med Sci Sports Exerc. 2008 Nov;40(11):1939-44
references.pmid: 18845972
references.citation: Comp Biochem Physiol A Mol Integr Physiol. 2001 Apr;128(4):777-89
references.pmid: 11282321
references.citation: Metabolism. 2013 May;62(5):609-21
references.pmid: 23084034
references.citation: Eur J Appl Physiol. 2009 Jan;105(1):19-25
references.pmid: 18815804
references.citation: Am J Med. 1993 Sep;95(3):309-14
references.pmid: 8368228