title: Once-daily antiretroviral therapy in a cohort of HIV-infected children and adolescents.
abstract: We evaluated the evolution over time of once-daily antiretroviral therapy in HIV-infected children and its relationship with adherence. An increase on the prevalence of once-daily antiretroviral therapy was observed over time (from 0.9% in 2002 to 44.2% in 2011). There was no difference in adherence regarding once-daily or BID regimens in 2011. Adherence was related to age and pill burden.
authors.affiliation: From the *Pediatrics Department, Hospital Infanta Sofía, San Sebastián de los Reyes; †Pediatrics Department, Hospital Principe de Asturias, Alcalá de Henares; ‡Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Universitario La Paz; §Division of Pediatric Infectious Diseases, Hospital Universitario 12 de Octubre; ¶Pediatric Immunology Department, Hospital General Universitario Gregorio Marañón; ‖Pediatrics Department, Hospital Universitario Niño Jesús; **Pediatric Infectious Diseases Department, Hospital Carlos III; ††Division of Pediatric Infectious Diseases, Hospital Universitario Gregorio Marañón; ‡‡Pediatrics Department, Hospital de Móstoles, Madrid; §§Laboratorio InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), and ¶¶Pediatrics Department, Hospital Universitario de Getafe, Madrid, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Jiménez-Montero
authors.forename: José
authors.initials: J
authors.lastname: Beceiro
authors.forename: M Isabel
authors.initials: MI
authors.lastname: de José-Gómez
authors.forename: M Isabel
authors.initials: MI
authors.lastname: González-Tomé
authors.forename: Dolores
authors.initials: D
authors.lastname: Gurbindo-Gutierrez
authors.forename: Jorge
authors.initials: J
authors.lastname: Martínez-Pérez
authors.forename: M José
authors.initials: MJ
authors.lastname: Mellado-Peña
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Navarro-Gómez
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Roa-Francia
authors.forename: Pablo
authors.initials: P
authors.lastname: Rojo-Conejo
authors.forename: Jesús
authors.initials: J
authors.lastname: Saavedra-Lozano
authors.forename: Santiago
authors.initials: S
authors.lastname: Jiménez de Ory
authors.forename: José T
authors.initials: JT
authors.lastname: Ramos-Amador
mesh_terms: D000293:Adolescent; D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D002648:Child; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D055118:Medication Adherence; D012189:Retrospective Studies
chemical_list: D044966:Anti-Retroviral Agents