title: Obesity is associated with retinopathy and macrovascular disease in type 1 diabetes.
abstract: Excessive body weight is increasingly seen in type 1 diabetes but its impact is debated. To address this uncertainty, we aimed to determine the association between excess body weight and the macro- and microvascular complications of type 1 diabetes. We identified 501 adults with type 1 diabetes attending an Australian hospital clinic and extracted their clinical and biochemical data from our patient management database. In both men and women, obesity (BMI > 30 kg/m(2)) was the predominant risk factor for retinopathy and cardiovascular disease despite similar HbA1c and increased use of cardioprotective drugs compared to non-obese patients. Obesity was associated with albuminuria in women, but not renal impairment or neuropathy in either sex. We conclude that obesity in type 1 diabetes may promote retinopathy and macrovascular disease. Future trials to determine the effect of weight loss on type 1 diabetes in obese people are needed.
authors.affiliation: Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Australia.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Price
authors.affiliation: Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Australia.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Gorelik
authors.affiliation: Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Australia.
authors.forename: Spiros
authors.initials: S
authors.lastname: Fourlanos
authors.affiliation: Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Australia.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Colman
authors.affiliation: Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Australia.
authors.forename: John M
authors.initials: JM
authors.lastname: Wentworth
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000209:etiology*; D001315:Australia; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D016017:Odds Ratio; D012307:Risk Factors; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human