title: Pharmacokinetics of zidovudine dosed twice daily according to World Health Organization weight bands in Ugandan HIV-infected children.
abstract: Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6-6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC0-12h was 3.0 h.mg/L, which is higher than previously observed in adults, and was independently higher in those receiving higher doses, younger and underweight children. Higher exposure was also marginally associated with lower hemoglobin.
authors.affiliation: From the *Department of Pharmacy, Radboud University Medical Centre, Nijmegen, The Netherlands; †MRC Clinical Trials Unit, London, United Kingdom; ‡Paediatric Infectious Diseases Centre, Mulago; §Joint Clinical Research Centre, Kampala, Uganda; and ¶University of Zimbabwe Medical School, Harare, Zimbabwe.
authors.forename: Quirine
authors.initials: Q
authors.lastname: Fillekes
authors.forename: Lindsay
authors.initials: L
authors.lastname: Kendall
authors.forename: Sabrina
authors.initials: S
authors.lastname: Kitaka
authors.forename: Peter
authors.initials: P
authors.lastname: Mugyenyi
authors.forename: Philippa
authors.initials: P
authors.lastname: Musoke
authors.forename: Milly
authors.initials: M
authors.lastname: Ndigendawani
authors.forename: Mutsa
authors.initials: M
authors.lastname: Bwakura-Dangarembizi
authors.forename: Diana M
authors.initials: DM
authors.lastname: Gibb
authors.forename: David
authors.initials: D
authors.lastname: Burger
authors.forename: Ann Sarah
authors.initials: AS
authors.lastname: Walker
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D018592:Cross-Over Studies; D005260:Female; D017408:Guidelines as Topic; D015658:HIV Infections / Q000188:drug therapy*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D008297:Male; D010949:Plasma / Q000737:chemistry; D014454:Uganda; D014944:World Health Organization; D015215:Zidovudine / Q000008:administration & dosage* / Q000493:pharmacokinetics*
chemical_list: D019380:Anti-HIV Agents; D006454:Hemoglobins; D015215:Zidovudine
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