title: Pelvic mature cystic teratoma with neuroendocrine carcinoma: report of a rare association and review of literature.
abstract: Extra-gonadal malignant transformation of teratoma is rare and there are only a few reports available citing malignancy arising in the non-germ cell components. We hereby report a case of a 35-year-old female, who presented with lower backache with a radiologically identifiable mass lesion in the pre-sacral region. Clinical and radiological findings suggested the possibility of a cystic teratoma. Histopathological examination and relevant immunohistochemical tests detected a mature cystic teratoma with features of a grade 2 neuroendocrine tumor in it. Like the index case, most of the previously reported cases of teratoma with malignant transformation of the somatic components were found in extra-gonadal site. This case is being reported to emphasize that any extra-gonadal mass in reproductive age group, even if it appears radiologically and per-operatively benign, must be subjected to histopathological examination to rule out possibility of malignant transformation of the germ cell or non-germ cell components.
authors.forename: Mukund N
authors.initials: MN
authors.lastname: Sable
authors.forename: Debojit
authors.initials: D
authors.lastname: Nath
authors.forename: Sunil
authors.initials: S
authors.lastname: Chumbar
authors.forename: Chandan J
authors.initials: CJ
authors.lastname: Das
authors.forename: Pratyusha
authors.initials: P
authors.lastname: Priyadarshini
authors.forename: Kavneet
authors.initials: K
authors.lastname: Kaur
authors.forename: Richa
authors.initials: R
authors.lastname: Ranjan
authors.forename: Siddhartha Datta
authors.initials: SD
authors.lastname: Gupta
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Prasenjit
authors.initials: P
authors.lastname: Das
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D018278:Carcinoma, Neuroendocrine / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D008853:Microscopy; D010386:Pelvic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D011860:Radiography, Abdominal; D016708:Synaptophysin / Q000032:analysis; D013724:Teratoma / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D016708:Synaptophysin; D007633:Keratins