title: Mucositis care in acute leukemia and non-Hodgkin lymphoma patients undergoing high-dose chemotherapy.
abstract: OBJECTIVE
  This study intends to provide new insights into the incidence and care of mucositis by the epidemiological characterization of patients with hematological malignancy treated at our institution. It also aims to understand the effectiveness of several treatments used.
  
  
  METHODS
  This is a longitudinal observational single-center study-convenience sample-which includes malignant hematologic inpatients submitted to high-dose CT from February to August 2012. We registered epidemiological data, diagnosis, oral mucositis daily questionnaire (OMDQ), World Health Organization (WHO) oral toxicity scale, and supportive medications used for mucositis.
  
  
  RESULTS
  We evaluated 30 patients who had 73 episodes of hospitalization, having recorded the development of mucositis in 21.9 % (n = 16) episodes (22 patients with acute leukemia (AL) and 8 patients with non-Hodgkin lymphoma (NHL)). Grades 3-4 mucositis was reported in 4.1 % of the total episodes. The results of OMDQ showed some limitations in the quality of life, of patients with mucositis, related with the ability to eat and drink due to mouth pain (p < 0.001). In patients with NHL and AL, neutropenia entails an increased risk of mucositis (p < 0.001). Patients who did not initiate early prophylaxis with conservative measures developed mucositis earlier (p < 0.05).
  
  
  CONCLUSIONS
  The incidence of mucositis is high, being reported mainly in AL patients, with limitations in quality of life. Grade 4 neutropenia increases mucositis risk. Early prophylaxis with basic oral care may delay mucositis. Further studies are crucial to characterize mucositis epidemiology, physiopathology, and its management.
authors.affiliation: Serviço de OncoHematologia, Instituto Português de Oncologia do Porto, Francisco Gentil, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal, jmmartinez@ipoporto.min-saude.pt.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Martinez
authors.forename: Dulcineia
authors.initials: D
authors.lastname: Pereira
authors.forename: Sérgio
authors.initials: S
authors.lastname: Chacim
authors.forename: Edgar
authors.initials: E
authors.lastname: Mesquita
authors.forename: Inês
authors.initials: I
authors.lastname: Sousa
authors.forename: Ângelo
authors.initials: Â
authors.lastname: Martins
authors.forename: Teresa
authors.initials: T
authors.lastname: Azevedo
authors.forename: José Mário
authors.initials: JM
authors.lastname: Mariz
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000188:drug therapy* / Q000453:epidemiology; D008137:Longitudinal Studies; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D013280:Stomatitis / Q000139:chemically induced / Q000453:epidemiology / Q000628:therapy*; D011795:Surveys and Questionnaires; D055815:Young Adult
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