title: Osseous reconstruction using an occlusive titanium membrane following marginal mandibulectomy: proof of principle.
abstract: Guided bone regeneration using barrier membranes is useful in bone augmentation. In contrast to flexible membranes, stiff membranes such as titanium membranes are capable of maintaining sufficient space underneath them. We report a case of bone regeneration under an occlusive titanium membrane following marginal mandibulectomy in a 50-year-old patient with odontogenic keratocyst. Preoperative analysis of the anatomical conditions was evaluated with panoramic radiographs and spiral computer tomography (CT) scan. The digital data from the CT scan were transferred to a personal computer. Using Simplant software, a mirror image of the right mandible was constructed from which a custom-made titanium membrane was made. The cyst with the remaining inferior alveolar nerve was removed and curettage of the lesion was performed under general anesthesia. The definitive titanium plate was inserted and fixated with osteosynthesis screws, and then removed 5 years later. Postoperative CT scanning showed good healing, bone growth under the titanium plate, and no evidence of residual cyst The titanium plate reinforced the mandibular skeleton and restored the shape of the mandible and facial symmetry; it also promoted new bone formation to fill in the mandibular defects.
authors.affiliation: From the *Oral and Maxillofacial Surgery, St. John's Hospital, Genk; †Faculty of Medicine, Hasselt University, Diepenbeek; ‡Oral and Maxillofacial Surgery, Faculty of Medicine, Gent University, Gent; and §Department of Imagine & Pathology/OMFS-IMPATH Research Group, KU Leaven, Group Biomedical Sciences, Oral and Maxillofacial Surgery, UZ Leaven, Leuven, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Vrielinck
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Serge
authors.initials: S
authors.lastname: Schepers
authors.forename: Constantinus
authors.initials: C
authors.lastname: Politis
authors.forename: Sarah
authors.initials: S
authors.lastname: Van Slycke
authors.forename: Jimoh Olubanwo
authors.initials: JO
authors.lastname: Agbaje
mesh_terms: D001861:Bone Regeneration; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery*; D008567:Membranes, Artificial; D008875:Middle Aged; D019647:Oral Surgical Procedures / Q000379:methods*; D019651:Plastic Surgery Procedures / Q000379:methods*; D014025:Titanium / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D008567:Membranes, Artificial; D014025:Titanium