title: A framework for modeling and visualizing cardiovascular deformation under normal and altered circulatory conditions.
abstract: The aim of this paper is to model and visualize cardiovascular deformations in order to better understand vascular movements inside the lung and heart caused by abnormal cardiac conditions. The modeling was performed in two steps: first step involved modeling the cardiac output taking into account of the heart rate and preload blood volume, contractility and systematic vascular resistance. The second step involved deforming a 3D cine cardiac gated Magnetic Resonance Volume to the corresponding cardiac output. Cardiac-gated MR imaging of 4 healthy volunteers were acquired. For each volunteer, a total of 24 short-axis and 18 radial planar views were acquired on a 1.5 T MR scanner during a series of 12-15 second breath-hold maneuvers. A 3D multi-resolution optical flow deformable image registration algorithm was used to quantify the volumetric cardiovascular displacements for known cardiac outputs. Results show that a real-time visualization of the vascular deformations inside both the lung as well as the heart can be seen for different cardiac outputs representing normal and abnormal cardiac conditions.
authors.affiliation: Department of Radiation Oncology, University of California, Los Angeles.
authors.forename: Anand
authors.initials: A
authors.lastname: Santhanam
authors.affiliation: Division of Cardiac Surgery, University of California, Los Angeles.
authors.forename: Peyman
authors.initials: P
authors.lastname: Benharash
authors.affiliation: Division of Cardiac Surgery, University of California, Los Angeles.
authors.forename: Paul
authors.initials: P
authors.lastname: Frank
authors.affiliation: Department of Radiation Oncology, University of California, Los Angeles.
authors.forename: Benjamin
authors.initials: B
authors.lastname: White
authors.affiliation: Department of Radiation Oncology, University of California, Los Angeles.
authors.forename: Yugang
authors.initials: Y
authors.lastname: Min
authors.affiliation: Department of Radiological Sciences, University of California, Los Angeles.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ennis
authors.affiliation: Department of Radiation Oncology, University of California, Los Angeles.
authors.forename: Patrick
authors.initials: P
authors.lastname: Kupelian
authors.affiliation: Computer Aided Surgical and Interventional Technologies, University of California, Los Angeles.
authors.forename: Erik
authors.initials: E
authors.lastname: Dutson
mesh_terms: D003198:Computer Simulation; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000502:physiology* / Q000503:physiopathology; D008955:Models, Cardiovascular