title: Noncompliance is an impact factor in the treatment of gastroesophageal reflux disease.
abstract: The basis of pharmacological treatment of the gastroesophageal reflux disease is the use of proton pump inhibitors (PPIs) which provide effective gastric acid secretion blockade. However, PPI therapy failure may occur in up to 42% of patients. The main causes for therapeutic failure are non-acid or weakly acid reflux, genotypic differences, presence of comorbidities, wrong diagnosis and lack of treatment compliance. Noncompliance is an important issue and should be carefully observed. Several studies addressed patient compliance and 20-50% of patients may present lack of compliance to the PPI prescribed. When symptoms persist depite adherence has been confirmed, it is recommended to substitute the prescribed PPI to another of the same class or alternatively, prescription of a double dose of the same drug. When even so the symptoms persist, other causes of failure should be assigned. In particular cases of PPI failure, fundoplication surgery may be indicated.
authors.affiliation: State University of Rio de Janeiro, Universidade do Estado do Rio de Janeiro - Gastroenterology, Boulevard 28 de stembro, 77, Rio de Janeiro, RJ 20551-030, Brazil.
authors.forename: Gerson
authors.initials: G
authors.lastname: Domingues
authors.forename: Joaquim Prado P
authors.initials: JP
authors.lastname: Moraes-Filho
mesh_terms: D015897:Comorbidity; D004305:Dose-Response Relationship, Drug; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D018434:Sickness Impact Profile; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors
keywords: GERD treatment; adherence; compliance; gastroesophageal reﬂux disease; proton pump inhibitors