title: Wnt5a: a potential factor linking psoriasis to metabolic complications.
abstract: Psoriasis is associated with comorbidity including obesity, insulin resistance and diabetes mellitus type 2. In obesity, the protein wingless-type MMTV integration site Family, Member 5a (wnt5a) is released from adipose tissue macrophages and was shown to be of importance in the development of insulin resistance. As wnt5a was also shown to be upregulated in psoriatic skin lesions, we investigated whether wnt5a and its counterpart secreted frizzled-related protein 5 are altered in the circulation of lean and obese patients with psoriasis compared with lean and obese healthy volunteers by measuring serum concentrations of both proteins. Our results showed that wnt5a was significantly higher in lean patients with psoriasis (0.096 ng/ml; SD 0.12) compared with lean healthy controls (0.020 ng/ml; SD 0.04; P ≤ 0.01) as well as in obese patients (0.177 ng/ml; SD 0.14) compared with obese healthy controls (0.011 ng/ml; SD 0.03; P ≤ 0.001). Therefore, we suggest that in psoriasis, an increase in wnt5a may contribute to the development of metabolic comorbidity.
authors.affiliation: Psoriasis-Center at the Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
authors.forename: Sascha
authors.initials: S
authors.lastname: Gerdes
authors.forename: Matthias
authors.initials: M
authors.lastname: Laudes
authors.forename: Katrin
authors.initials: K
authors.lastname: Neumann
authors.forename: Hansjoerg
authors.initials: H
authors.lastname: Baurecht
authors.forename: Ulrich
authors.initials: U
authors.lastname: Mrowietz
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D005136:Eye Proteins / Q000097:blood / Q000502:physiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008565:Membrane Proteins / Q000097:blood / Q000502:physiology; D008659:Metabolic Diseases / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D011518:Proto-Oncogene Proteins / Q000097:blood* / Q000502:physiology; D011565:Psoriasis / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology; D051153:Wnt Proteins / Q000097:blood* / Q000502:physiology; D000071818:Wnt-5a Protein; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D005136:Eye Proteins; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; C118511:SFRP5 protein, human; D000094742:Secreted Frizzled-Related Proteins; C085389:WNT5A protein, human
keywords: comorbidity; obesity; psoriasis; sFRP5; wnt5a