title: Epigenetics of idiopathic pulmonary fibrosis.
abstract: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease of unknown etiology. Development of IPF is influenced by both genetic and environmental factors. Recent work by our and other groups has identified strong genetic predisposition factors for the development of pulmonary fibrosis, and cigarette smoke remains the most strongly associated environmental exposure risk factor. Gene expression profiling studies of IPF lung have taught us quite a bit about the biology of this fatal disease, and those of peripheral blood have provided important biomarkers. However, epigenetic marks may be the missing link that connects the environmental exposure in genetically predisposed individuals to transcriptional changes associated with disease development. Moreover, epigenetic marks represent a promising therapeutic target for IPF. In this review, the disease is introduced, genetic and gene expression studies in IPF are summarized, exposures relevant to IPF and known epigenetic changes associated with cigarette smoke exposure are discussed, and epigenetic studies conducted so far in IPF are summarized. Limitations, challenges, and future opportunities in this field are also discussed.
authors.affiliation: Department of Medicine, University of Colorado School of Medicine, Aurora, Colo; Department of Epidemiology, Colorado School of Public Health, Aurora, Colo. Electronic address: ivana.yang@yahoo.com.
authors.forename: Ivana V
authors.initials: IV
authors.lastname: Yang
authors.affiliation: Department of Medicine, University of Colorado School of Medicine, Aurora, Colo; Department of Immunology, University of Colorado School of Medicine, Aurora, Colo.
authors.forename: David A
authors.initials: DA
authors.lastname: Schwartz
mesh_terms: D000818:Animals; D004781:Environmental Exposure / Q000009:adverse effects; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000209:etiology* / Q000235:genetics* / Q000503:physiopathology; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D057170:Translational Research, Biomedical
chemical_list: D035683:MicroRNAs
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