title: A primary systemic ALCL present initially as cutaneous localized skin lesions: report of an unusual case.
abstract: Anaplastic large cell lymphoma (ALCL) is classified into systemic and primary cutaneous subtypes. A primary systemic ALCL present initially as cutaneous localized skin lesions is a rare presentation. We present an unusual case of a 13-year-old boy with systemic ALCL who presented with cutaneous nodules. The systemic nature of this lymphoma was confirmed by immunohistochemical positivity of anaplastic lymphoma kinase and epithelial membrane antigen. Confirmation of this diagnosis will lead to a poorer prognosis and more aggressive systemic therapy.
authors.affiliation: *Department of Pathology, King Fahd University Hospital, University of Dammam, Dammam, Kingdom of Saudi Arabia; and †Department of Pathology, King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: ALSayyah
authors.forename: Ahmed
authors.initials: A
authors.lastname: AlHumidi
mesh_terms: D000293:Adolescent; D000077548:Anaplastic Lymphoma Kinase; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D006801:Humans; D007150:Immunohistochemistry; D017728:Lymphoma, Large-Cell, Anaplastic / Q000737:chemistry / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000737:chemistry / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000737:chemistry / Q000473:pathology*; D008297:Male; D018396:Mucin-1 / Q000032:analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; C060192:MUC1 protein, human; D018396:Mucin-1; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases