title: Very-high-dose caspofungin combined with voriconazole to treat central nervous system aspergillosis: substantial penetration of caspofungin into cerebrospinal fluid.
authors.affiliation: Assistance Publique Hôpitaux de Paris AP-HP, Hôpital Bichat-Claude-Bernard, Service de Réanimation Médicale et Infectieuse, Université Paris Diderot, Sorbonne Paris Cité, Paris, France f.reminiac@yahoo.fr.
authors.forename: François
authors.initials: F
authors.lastname: Réminiac
authors.affiliation: Assistance Publique Hôpitaux de Paris AP-HP, Hôpital Bichat-Claude-Bernard, Service de Réanimation Médicale et Infectieuse, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Sonneville
authors.affiliation: Assistance Publique Hôpitaux de Paris AP-HP, Hôpital Bichat-Claude-Bernard, Laboratoire de Toxicologie-Pharmacocinétique, Service de Pharmacie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Massias
authors.affiliation: Assistance Publique Hôpitaux de Paris AP-HP, Hôpital Bichat-Claude-Bernard, Service de Parasitologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Chochillon
authors.affiliation: Assistance Publique Hôpitaux de Paris AP-HP, Hôpital Bichat-Claude-Bernard, Service de Réanimation Médicale et Infectieuse, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Wolff
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D001232:Aspergillus fumigatus / Q000187:drug effects*; D000077336:Caspofungin; D002493:Central Nervous System Diseases / Q000188:drug therapy* / Q000382:microbiology; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D006801:Humans; D055666:Lipopeptides / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D008297:Male; D020953:Neuroaspergillosis / Q000188:drug therapy*; D065819:Voriconazole / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin; D065819:Voriconazole
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