title: Relative bioavailability of soil-bound chlordecone in growing lambs.
abstract: The pollution of soil with the pesticide chlordecone (CLD) is a problem for the use of agricultural surfaces even years after its use has been forbidden. Therefore, the exposure of free-ranged animals such as ruminants needs to be investigated in order to assess the risk of contamination of the food chain. Indeed, measured concentrations could be integrated in a lowered extent if the soil binding would reduce the bioavailability of the pesticide. This bioavailability of soil-bound CLD in a heavily polluted andosol has been investigated relatively of CLD given via spiked oil. Twenty-four weaned lambs were exposed to graded doses of 2, 4 or 6 μg CLD/kg body weight during 15 days via the contaminated soil in comparison to spiked oil. The concentration of this pesticide has been determined in two target tissues: blood serum and kidney fat. The relative bioavailability (RBA) corresponds to the slope ratio between the test matrix-contaminated soil- in comparison to the reference matrix oil. The RBA of the soil-bound CLD was not found to significantly differ from the reference matrix oil in lambs meaning that the pesticide ingested by grazing ruminants would not be sequestered by soil binding. Therefore, CLD from soil gets bioavailable within the intestinal level and exposure to contaminated soil has to be integrated in risk assessments.
authors.affiliation: UR Animal et Fonctionnalités des Produits Animaux, USC 340, Université de Lorraine, INRA, ENSAIA 2 avenue de la Forêt de Haye, TSA 40602, 54518, Vandoeuvre-lès-Nancy Cedex, France, stefan.jurjanz@univ-lorraine.fr.
authors.forename: S
authors.initials: S
authors.lastname: Jurjanz
authors.forename: C
authors.initials: C
authors.lastname: Jondreville
authors.forename: M
authors.initials: M
authors.lastname: Mahieu
authors.forename: A
authors.initials: A
authors.lastname: Fournier
authors.forename: H
authors.initials: H
authors.lastname: Archimède
authors.forename: G
authors.initials: G
authors.lastname: Rychen
authors.forename: C
authors.initials: C
authors.lastname: Feidt
mesh_terms: D000821:Animal Feed; D000818:Animals; D007631:Chlordecone / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D007306:Insecticides / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D050152:Intra-Abdominal Fat / Q000378:metabolism; D018570:Risk Assessment; D012756:Sheep / Q000378:metabolism*; D012987:Soil / Q000737:chemistry; D012989:Soil Pollutants / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*
chemical_list: D007306:Insecticides; D012987:Soil; D012989:Soil Pollutants; D007631:Chlordecone
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