title: Combinations of genetic data in a study of neuroblastoma risk genotypes.
abstract: Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among the latter, a cluster of 24 combinations was found to be significantly associated with NB (P < 0.00001).
authors.affiliation: Department of Molecular Medicine and Medical Biotechnologies, University of Napoli Federico II, Naples, Italy; CEINGE (Centro Ingegneria Genetica) Advanced Biotechnologies, Naples, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Capasso
authors.affiliation: CEINGE (Centro Ingegneria Genetica) Advanced Biotechnologies, Naples, Italy.
authors.forename: Francesco Maria
authors.initials: FM
authors.lastname: Calabrese
authors.affiliation: Department of Molecular Medicine and Medical Biotechnologies, University of Napoli Federico II, Naples, Italy; CEINGE (Centro Ingegneria Genetica) Advanced Biotechnologies, Naples, Italy.
authors.forename: Achille
authors.initials: A
authors.lastname: Iolascon
authors.affiliation: Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, Faculty of Health, University of Copenhagen, Copenhagen, Denmark. Electronic address: mellerup@hotmail.com.
authors.forename: Erling
authors.initials: E
authors.lastname: Mellerup
mesh_terms: D005838:Genotype; D006801:Humans; D009447:Neuroblastoma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
keywords: Neuroblastoma; SNPs; combinations; data mining