title: Amylopectin-g-poly(N-vinyl-2-pyrrolidone): synthesis, characterization and in vitro release behavior.
abstract: In the present study, amylopectin-g-poly(N-vinyl-2-pyrrolidone) was synthesized by UV-assisted grafting reactions. The effect of concentrations of amylopectin, N-vinyl-pyrrolidone and ammonium persulfate on the % grafting efficiency was studied using 3-factor, 2-level factorial experimental design. The graft co-polymer was characterized by Fourier-transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and scanning electron microscopy (SEM) studies. The concentrations of amylopectin, N-vinyl-2-pyrrolidone and ammonium persulfate were found to exert a significant synergistic effect on grafting efficiency. The optimized batch of graft co-polymer prepared using concentration of amylopectin (4%), N-vinyl-2-pyrrolidone (2%) and ammonium persulfate (10 mmol/L) had 83.16% grafting efficiency. On comparative evaluation of films of amylopectin-g-poly(N-vinyl-pyrrolidone) with amylopectin, the graft co-polymer film provided a prolonged release following Higuchi square release kinetics.
authors.affiliation: Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar 125 001, India. Electronic address: munishahuja17@yahoo.co.in.
authors.forename: Munish
authors.initials: M
authors.lastname: Ahuja
authors.affiliation: Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar 125 001, India.
authors.forename: Kanika
authors.initials: K
authors.lastname: Thakur
authors.affiliation: Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar 125 001, India.
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000645:Ammonium Sulfate / Q000737:chemistry; D000687:Amylopectin / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D011108:Polymers; D011760:Pyrrolidinones; C031276:ammonium peroxydisulfate; C042670:N-vinyl-2-pyrrolidinone; D000687:Amylopectin; C028537:2-pyrrolidone; D000645:Ammonium Sulfate
keywords: Amylopectin; Factorial design; Graft co-polymer; N-vinyl-pyrrolidone