title: Delayed onset renal failure in a patient on tenofovir based antiretroviral regimen.
abstract: Tenofovir is recommended as one of the first line agents in combination with other antiretroviral drugs for management of human immunodeficiency virus (HIV). It is known to cause renal failure after exposure for a median duration of 5 months. We report tenofovir induced adverse drug reaction in a 56-year-old female patient who was diagnosed to have HIV 1 infection since 10 years. The combination antiretroviral treatment included tenofovir, emtricitabine and ritonavir/lopinavir regimen since the last 6 years. She presented with recent onset renal failure and renal biopsy showed interstitial nephritis which could probably attributable to tenofovir.
authors.affiliation: Department of General Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India.
authors.forename: M Murali
authors.initials: MM
authors.lastname: Krishna
authors.affiliation: Department of General Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India.
authors.forename: M V S
authors.initials: MV
authors.lastname: Subbalaxmi
authors.affiliation: Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India.
authors.forename: Megha
authors.initials: M
authors.lastname: Uppin
authors.affiliation: Department of Clinical Pharmacology and Theurapeutics, Nizam's Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India.
authors.forename: S
authors.initials: S
authors.lastname: Radhika
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D063065:Organophosphonates / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000473:pathology; D000068698:Tenofovir
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D000068698:Tenofovir; D000225:Adenine
keywords: Human immunodeficiency virus; renal failure; tenofovir
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