title: Serum adiponectin in gestational diabetes and its relation to pregnancy outcome.
abstract: We investigated adiponectin levels in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) at 24-28 gestational weeks. Fasting serum adiponectin, glucose and glycated haemoglobin (HbA1c) were determined in 88 pregnant women, 44 with GDM and 44 with NGT. Pre-pregnancy and current body mass indices (BMI), weight gain and pregnancy outcomes were investigated. Serum adiponectin was significantly reduced in GDM compared with the NGT group (p = 0.000). Adiponectin was negatively correlated with age (r = -0.419, p = 0.000); glucose (r = -0.263, p = 0.013); HbA1c (r = -0.274, p = 0.01); BMI (pre-pregnancy and current) (r = -0.317, p = 0.003 and r = -0.303, p = 0.004) and positively correlated with gestational age at delivery (r = 0.278, p = 0.009). The GDM group delivered significantly earlier than the NGT group (p = 0.001). Adverse pregnancy outcomes and abdominal delivery were higher in the GDM group (p = 0.000, p = 0.033, respectively), and adiponectin was significantly reduced in patients with adverse outcomes (p = 0.003) and abdominal delivery (p = 0.032). Adiponectin is reduced in patients with GDM. Association of adiponectin with adverse pregnancy outcomes remains to be elucidated.
authors.affiliation: Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Doruk
authors.forename: M
authors.initials: M
authors.lastname: Uğur
authors.forename: A S
authors.initials: AS
authors.lastname: Oruç
authors.forename: N
authors.initials: N
authors.lastname: Demirel
authors.forename: Y
authors.initials: Y
authors.lastname: Yildiz
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000453:epidemiology; D011256:Pregnancy Outcome; D011446:Prospective Studies; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D052242:Adiponectin
keywords: Adiponectin; adverse pregnancy outcomes; gestational diabetes mellitus