title: Studying aging in Drosophila.
abstract: Drosophila melanogaster represents one of the most important genetically accessible model organisms for aging research. Studies in flies have identified single gene mutations that influence lifespan and have characterized endocrine signaling interactions that control homeostasis systemically. Recent studies have focused on the effects of aging on specific tissues and physiological processes, providing a comprehensive picture of age-related tissue dysfunction and the loss of systemic homeostasis. Here we review methodological aspects of this work and highlight technical considerations when using Drosophila to study aging and age-related diseases.
authors.affiliation: Buck Institute for Research on Aging, Novato, CA, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.affiliation: Buck Institute for Research on Aging, Novato, CA, USA. Electronic address: HJasper@buckinstitute.org.
authors.forename: Heinrich
authors.initials: H
authors.lastname: Jasper
mesh_terms: D000375:Aging / Q000235:genetics* / Q000473:pathology; D000818:Animals; D015509:Developmental Biology / Q000379:methods*; D004330:Drosophila / Q000235:genetics / Q000254:growth & development*; D006706:Homeostasis; D023421:Models, Animal
keywords: Aging; Degeneration; Drosophila; Homeostasis
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