title: Feasibility of oral prenatal probiotics against maternal group B Streptococcus vaginal and rectal colonization.
abstract: OBJECTIVE
  To examine the effect of an oral prenatal probiotic on group B Streptococcus (GBS) colonization and to demonstrate the feasibility of a larger randomized controlled trial.
  
  
  METHODS
  This pilot study was an open-label, two-group quasi-experiment.
  
  
  METHODS
  An urban central city nurse-midwifery and wellness center serving a diverse population.
  
  
  METHODS
  Ten pregnant participants received the oral probiotic (Florajen3) taken once daily, and 10 participants served as controls.
  
  
  METHODS
  A questionnaire on dietary practices, vaginal cleansing, sexual history, and symptoms and GBS colony count samples were taken at 28-, 32-, and 36-weeks gestation.
  
  
  RESULTS
  Participants in the probiotic group reported no adverse events or minor side effects; one half reported improved gastrointestinal symptoms. Although two women in each group had positive qualitative prenatal GBS cultures at 36 weeks, the probiotic group participants had lower quantitative GBS colony counts. The eight GBS negative averaged 90% probiotic adherence compared with two GBS positive women who averaged 68%. Yogurt ingestion was inversely related (p = .02) to GBS colonization.
  
  
  CONCLUSIONS
  Prenatal probiotic therapy has the potential to reduce GBS colonization. The potential of the probiotic intervention appears to be linked to daily adherence. A controlled clinical trial with a larger, adequately powered sample is feasible and justified.
authors.forename: Lisa
authors.initials: L
authors.lastname: Hanson
authors.forename: Leona
authors.initials: L
authors.lastname: Vandevusse
authors.forename: Megan
authors.initials: M
authors.lastname: Duster
authors.forename: Simone
authors.initials: S
authors.lastname: Warrack
authors.forename: Nasia
authors.initials: N
authors.lastname: Safdar
mesh_terms: D000284:Administration, Oral; D000328:Adult; D016009:Chi-Square Distribution; D015169:Colony Count, Microbial; D016001:Confidence Intervals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005240:Feasibility Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D018579:Patient Selection; D010865:Pilot Projects; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control*; D011295:Prenatal Care / Q000379:methods; D019936:Probiotics / Q000008:administration & dosage*; D012007:Rectum / Q000382:microbiology; D013290:Streptococcal Infections / Q000517:prevention & control*; D013292:Streptococcus agalactiae / Q000302:isolation & purification*; D016896:Treatment Outcome; D014481:United States; D014505:Urban Population; D014621:Vagina / Q000382:microbiology
keywords: group B Streptococcus; pregnancy; probiotics