title: Modulation of circulating cytokine-chemokine profile in patients affected by chronic venous insufficiency undergoing surgical hemodynamic correction.
abstract: The expression of proinflammatory cytokines/chemokines has been reported in in vitro/ex vivo settings of chronic venous insufficiency (CVI), but the identification of circulating mediators that might be associated with altered hemodynamic forces or might represent innovative biomarkers is still missing. In this study, the circulating levels of 31 cytokines/chemokines involved in inflammatory/angiogenic processes were analysed in (i) CVI patients at baseline before surgical hemody namic correction, (ii) healthy subjects, and (iii) CVI patients after surgery. In a subgroup of CVI patients, in whom the baseline levels of cytokines/chemokines were analyzed in paired blood samples obtained from varicose vein and forearm vein, EGF, PDGF, and RANTES were increased at the varicose vein site as compared to the general circulation. Moreover, while at baseline, CVI patients showed increased levels of 14 cytokines/chemokines as compared to healthy subjects, 6 months after surgery, 11 cytokines/chemokines levels were significantly reduced in the treated CVI patients as compared to the CVI patients before surgery. Of note, a patient who exhibited recurrence of the disease 6 months after surgery, showed higher levels of EGF, PDGF, and RANTES compared to nonrecurrent patients, highlighting the potential role of the EGF/PDGF/RANTES triad as sensitive biomarkers in the context of CVI.
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, 44121 Ferrara, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Tisato
authors.affiliation: Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Via dell'Istria 65/01, 34137 Trieste, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Zauli
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, 44121 Ferrara, Italy ; Vascular Disease Center, University of Ferrara, Via Aldo Moro 8, 44124 Ferrara, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Gianesini
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, 44121 Ferrara, Italy ; Vascular Disease Center, University of Ferrara, Via Aldo Moro 8, 44124 Ferrara, Italy.
authors.forename: Erica
authors.initials: E
authors.lastname: Menegatti
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, 44121 Ferrara, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Brunelli
authors.affiliation: Department of Medical Sciences, Operative Unit of Clinica Medica, University Hospital of Ferrara, Via Aldo Moro 8, 44124 Ferrara, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Manfredini
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, 44121 Ferrara, Italy ; Vascular Disease Center, University of Ferrara, Via Aldo Moro 8, 44124 Ferrara, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Zamboni
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, 44121 Ferrara, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Secchiero
mesh_terms: D000328:Adult; D000368:Aged; D018925:Chemokines / Q000097:blood*; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012501:Saphenous Vein / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D014648:Varicose Veins / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D014689:Venous Insufficiency / Q000097:blood* / Q000175:diagnosis / Q000601:surgery*
chemical_list: D018925:Chemokines; D016207:Cytokines
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