title: Coexistence of cavernous hemangioma and other vascular malformations of the orbit. A report of three cases.
abstract: Coexistence of orbital cavernous hemangioma and other vascular malformations is unusual and few cases have been reported. We describe the clinical and radiological features of three cases of orbital cavernous hemangiomas associated with other vascular malformations, selected reviewing a series of 181 cases of cavernous hemangiomas. All patients were males (age ranging from 43 to 67 years) without vascular systemic disorders and/or a clinical syndrome. They experienced slow progressive exophthalmos. One of them developed acute pulsatile proptosis (case 2), while another experienced slow progressive diplopia (case 3). In one case vascular lesions were bilateral (case 3) and in two patients two different lesions coexisted in the same orbit (cases 1 and 2). All patients underwent surgical excision, which was partial in two cases. Two patients had cavernous hemangiomas in association with a venous malformation (a varix in case 1 and a lymphangioma in case 2), while in the other ones (case 3) cavernous hemangioma was associated with a low-flow arteriovenous malformation. No patient denied visual impairment postoperatively. Few cases of orbital cavernous hemangiomas coexisting with other vascular malformations have been reported in the literature. This entity seems to be an association of different variants of orbital vascular malformations, presenting with a wide spectrum of clinical forms and probably with the same pathogenesis.
authors.affiliation: Department of Neurosciences and Reproductive Sciences, "Federico II" University; Naples, Italy - c.russo01@libero.it.
authors.forename: Diego
authors.initials: D
authors.lastname: Strianese
authors.affiliation: Department of Advanced Biomedical Sciences, "Federico II" University; Naples, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Napoli
authors.affiliation: Department of Advanced Biomedical Sciences, "Federico II" University; Naples, Italy.
authors.forename: Carmela
authors.initials: C
authors.lastname: Russo
authors.affiliation: Department of Advanced Biomedical Sciences, "Federico II" University; Naples, Italy.
authors.forename: Arianna
authors.initials: A
authors.lastname: D'Errico
authors.affiliation: Department of Pediatrics, "Federico II" University; Naples, Italy.
authors.forename: Nadia
authors.initials: N
authors.lastname: Scotti
authors.affiliation: I Division of Neurology, Department of Clinical and Experimental Medicine, Second University of Naples; Naples, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Puoti
authors.affiliation: Department of Neurosciences and Reproductive Sciences, "Federico II" University; Naples, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Bonavolontà
authors.affiliation: Department of Neurosciences and Reproductive Sciences, "Federico II" University; Naples, Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Tranfa
authors.affiliation: Department of Advanced Biomedical Sciences, "Federico II" University; Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Briganti
mesh_terms: D000368:Aged; D001165:Arteriovenous Malformations / Q000000981:diagnostic imaging*; D018450:Disease Progression; D005094:Exophthalmos / Q000000981:diagnostic imaging*; D005134:Eye Neoplasms / Q000000981:diagnostic imaging*; D020786:Hemangioma, Cavernous, Central Nervous System / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000098:blood supply / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
keywords: MR; cavernous hemangioma; orbital vascular malformations
references.citation: Neuroradiol J. 2011 Aug 31;24(4):636-42
references.pmid: 24059723
references.citation: Orbit. 2004 Mar;23(1):33-40
references.pmid: 15513018
references.citation: Neuroradiol J. 2013 Apr;26(2):227-32
references.pmid: 23859247
references.citation: Br J Ophthalmol. 1992 Oct;76(10):627-9
references.pmid: 1420047
references.citation: J Neuroradiol. 1999 Jun;26(2):79-86
references.pmid: 10444931
references.citation: Zentralbl Neurochir. 2008 Nov;69(4):175-81
references.pmid: 18666054
references.citation: J Neurosurg. 1991 Sep;75(3):461-4
references.pmid: 1869949
references.citation: Ophthalmology. 2002 Mar;109(3):537-41
references.pmid: 11874758
references.citation: Ophthalmology. 2010 Mar;117(3):606-14
references.pmid: 20022639
references.citation: Neuroradiology. 2012 Oct;54(10):1145-52
references.pmid: 22569955
references.citation: Br J Neurosurg. 1997 Aug;11(4):346-9
references.pmid: 9337936
references.citation: Eur J Radiol. 2004 Feb;49(2):105-42
references.pmid: 14746934
references.citation: Br J Ophthalmol. 2000 Aug;84(8):928
references.pmid: 10979651
references.citation: Ophthalmic Plast Reconstr Surg. 2005 Nov;21(6):461-3
references.pmid: 16304530
references.citation: BMC Ophthalmol. 2013 May 30;13:21
references.pmid: 23721066
references.citation: Radiographics. 2008 Jan-Feb;28(1):185-204; quiz 325
references.pmid: 18203938
references.citation: J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):438-9
references.pmid: 17369598
references.citation: Am J Ophthalmol. 1990 Aug 15;110(2):153-9
references.pmid: 2198811
references.citation: Orbit. 2003 Jun;22(2):103-20
references.pmid: 12789590
references.citation: Orbit. 2010 Oct;29(5):281-3
references.pmid: 20572753
references.citation: Jpn J Ophthalmol. 2004 Jul-Aug;48(4):415-7
references.pmid: 15295674
references.citation: Neuroradiol J. 2012 Dec 20;25(6):695-701
references.pmid: 24029183
references.citation: World Neurosurg. 2014 Jul-Aug;82(1-2):e93-6
references.pmid: 23523677
references.citation: Am J Ophthalmol. 2001 Mar;131(3):364-70
references.pmid: 11239871
references.citation: Ophthalmic Plast Reconstr Surg. 2013 Mar-Apr;29(2):79-86
references.pmid: 23470516
references.citation: Ophthalmology. 1990 May;97(5):625-8
references.pmid: 2342808
references.citation: Semin Ultrasound CT MR. 2012 Oct;33(5):385-91
references.pmid: 22964404
references.citation: Ophthalmic Plast Reconstr Surg. 2013 Sep-Oct;29(5):412-3
references.pmid: 24022357
references.citation: Eur J Radiol. 2008 May;66(2):282-6
references.pmid: 17644295
references.citation: Br J Ophthalmol. 1988 Nov;72(11):871-3
references.pmid: 3207665
references.citation: Am J Ophthalmol. 2006 May;141(5):943-5
references.pmid: 16678512
references.citation: Surg Neurol. 1988 Jan;29(1):32-4
references.pmid: 3336837
references.citation: Neuroradiology. 2002 Jul;44(7):604-9
references.pmid: 12136363
references.citation: Eur J Radiol. 2013 Oct;82(10):1598-605
references.pmid: 23399038
references.citation: Ophthalmology. 2012 Feb;119(2):382-9
references.pmid: 21959369
references.citation: Surv Ophthalmol. 2008 Nov-Dec;53(6):543-58
references.pmid: 19026318
references.citation: J Neurosurg. 2005 Nov;103(5 Suppl):454-7
references.pmid: 16302620
references.citation: Minerva Anestesiol. 1996 Jun;62(6):209-12
references.pmid: 8937044