title: Priapism associated with iloperidone: a case report.
abstract: Priapism is a known side effect of antipsychotics. The causal mechanism seems to be mediated through α1-adrenergic receptor blockade which many antipsychotics are known to possess. We present the first detailed case of iloperidone-induced priapism in a patient with bipolar disorder with psychotic features. His case highlights some of the important risk factors clinicians should consider when using iloperidone, as it may be the highest-risk antipsychotic for causing priapism given it is a very potent blocker of the alpha-adrenergic receptor.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address: lisette.rodriguez-cabezas@northwestern.edu.
authors.forename: Lisette A
authors.initials: LA
authors.lastname: Rodriguez-Cabezas
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Betty Y
authors.initials: BY
authors.lastname: Kong
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Gaurava
authors.initials: G
authors.lastname: Agarwal
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy*; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects*; D008297:Male; D010880:Piperidines / Q000009:adverse effects*; D011317:Priapism / Q000139:chemically induced*
chemical_list: D014150:Antipsychotic Agents; D007555:Isoxazoles; D010880:Piperidines; C081732:iloperidone
keywords: Antipsychotics; Bipolar; Iloperidone; Priapism; Psychosis