title: Triple composite tumor of stomach: a rare combination of alpha fetoprotein positive hepatoid adenocarcinoma, tubular adenocarcinoma and large cell neuroendocrine carcinoma.
abstract: A 50-year-old male patient presented with pain abdomen of 6 months duration. Computed tomography scan revealed a large mass in the stomach occluding the lumen. Histopathology revealed a triple composite tumor comprising of tubular adenocarcinoma arising on a background of high-grade dysplasia, hepatoid adenocarcinoma (positive for Hep Par-1 and alpha fetoprotein) and large cell neuroendocrine carcinoma (positive for synaptophysin and chromogranin) with nodal metastasis.Triple composite tumors are distinctly rare with few reports in literature.
authors.forename: Lipika
authors.initials: L
authors.lastname: Lipi
authors.affiliation: Department of Pathology & Lab Medicine, Medanta-The Medicity Hospital, Gurgaon, Haryana, India.
authors.forename: Ritesh
authors.initials: R
authors.lastname: Sachdev
authors.forename: Dheeraj
authors.initials: D
authors.lastname: Gautam
authors.forename: Jasbir
authors.initials: J
authors.lastname: Singh
authors.forename: Ishani
authors.initials: I
authors.lastname: Mohapatra
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D011860:Radiography, Abdominal; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins