title: Allosteric control of a DNA-hydrolyzing deoxyribozyme with short oligonucleotides and its application in DNA logic gates.
abstract: Allosteric control of deoxyribozymes is useful for a broad range of practical applications, such as nucleic acid sensing and DNA-computing. We found that the catalytic activity of a DNA-hydrolyzing deoxyribozyme could be allosterically regulated by adding short oligonucleotides. We used this technique to construct deoxyribozyme-based logic gates.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1-78-1, Tokushima 770-8505, Japan. k.furukawa@tokushima-u.ac.jp minakawa@tokushima-u.ac.jp.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Furukawa
authors.forename: Noriaki
authors.initials: N
authors.lastname: Minakawa
mesh_terms: D000494:Allosteric Regulation; D001483:Base Sequence; D003067:Coenzymes / Q000378:metabolism; D021881:DNA, Catalytic / Q000378:metabolism*; D006868:Hydrolysis; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000378:metabolism*; D013696:Temperature; D013997:Time Factors
chemical_list: D003067:Coenzymes; D021881:DNA, Catalytic; D009841:Oligonucleotides