title: Cyclometalated iridium(III)-β-carboline complexes as potent autophagy-inducing agents.
abstract: Two cyclometalated Ir(III)-β-carboline complexes were identified as potent inducers of autophagic cell death. Autophagy induced by these complexes is ROS-mediated and caspase-independent.
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: He
authors.forename: Si-Yan
authors.initials: SY
authors.lastname: Liao
authors.forename: Cai-Ping
authors.initials: CP
authors.lastname: Tan
authors.forename: Yi-Ying
authors.initials: YY
authors.lastname: Lu
authors.forename: Cui-Xia
authors.initials: CX
authors.lastname: Xu
authors.forename: Liang-Nian
authors.initials: LN
authors.lastname: Ji
authors.forename: Zong-Wan
authors.initials: ZW
authors.lastname: Mao
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D001343:Autophagy / Q000187:drug effects*; D002243:Carbolines / Q000737:chemistry*; D002460:Cell Line; D006801:Humans; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D002243:Carbolines; D008024:Ligands; D009942:Organometallic Compounds; D007495:Iridium