title: Time-shift homotopic connectivity in mesial temporal lobe epilepsy.
abstract: OBJECTIVE
  Voxel-mirrored intrinsic functional connectivity allows the depiction of interhemispheric homotopic connections in the human brain, whereas time-shift intrinsic functional connectivity allows the detection of the extent of brain injury by measuring hemodynamic properties. We combined time-shift voxel-mirrored homotopic connectivity analyses to investigate the alterations in homotopic connectivity in mesial temporal lobe epilepsy and assessed the value of applying this approach to epilepsy lateralization and the prediction of surgical outcomes in mesial temporal lobe epilepsy.
  
  
  METHODS
  Resting-state functional MR imaging data were acquired from patients with unilateral mesial temporal lobe epilepsy (n=62) (31 left- and 31 right-side) and healthy controls (n=33). Dynamic interhemispheric homotopic architecture seeding from each hemisphere was individually calculated by 0, 1, 2, and 3 repetition time time-shift voxel-mirrored homotopic connectivity. Voxel-mirrored homotopic connectivity maps were compared between the patient and control groups by using 1-way ANOVA for each time-shift condition, separately. Group comparisons were further performed on the laterality of voxel-mirrored homotopic connectivity in each time-shift condition. Finally, we correlated the interhemispheric homotopic connection to the surgical outcomes in a portion of the patients (n=20).
  
  
  RESULTS
  The patients with mesial temporal lobe epilepsy showed decreased homotopic connectivity in the mesial temporal structures, temporal pole, and striatum. Alterations of the bihemispheric homotopic connectivity were lateralized along with delays in the time-shift in mesial temporal lobe epilepsy. The patients with unsuccessful surgical outcomes presented larger interhemispheric voxel-mirrored homotopic connectivity differences.
  
  
  CONCLUSIONS
  This study showed whole patterns of dynamic alterations of interhemispheric homotopic connectivity in mesial temporal lobe epilepsy, extending the knowledge of abnormalities in interhemispheric connectivity in this condition. Time-shift voxel-mirrored homotopic connectivity has the potential for lateralization of unilateral mesial temporal lobe epilepsy and may have the capability of predicting surgical outcomes in this condition.
authors.affiliation: From the Departments of Medical Imaging (Q.X., Z.Z., W.L., L.X., Q.J., G.L.).
authors.forename: Q
authors.initials: Q
authors.lastname: Xu
authors.affiliation: From the Departments of Medical Imaging (Q.X., Z.Z., W.L., L.X., Q.J., G.L.) zhangzq2001@126.com cjr.luguangming@vip.163.com.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: From the Departments of Medical Imaging (Q.X., Z.Z., W.L., L.X., Q.J., G.L.) Center for Cognition and Brain Disorders and the Affiliated Hospital (W.L.), Hangzhou Normal University, Hangzhou, China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments (W.L.), Hangzhou, China.
authors.forename: W
authors.initials: W
authors.lastname: Liao
authors.affiliation: From the Departments of Medical Imaging (Q.X., Z.Z., W.L., L.X., Q.J., G.L.).
authors.forename: L
authors.initials: L
authors.lastname: Xiang
authors.affiliation: Neurology (F.Y., G.C.).
authors.forename: F
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Medical Imaging (Z.W.), Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Neurology (F.Y., G.C.).
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.affiliation: Neurosurgery (Q.T.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Tan
authors.affiliation: From the Departments of Medical Imaging (Q.X., Z.Z., W.L., L.X., Q.J., G.L.) Department of Medical Imaging (Q.J.), Taishan Medical College, TaiAn, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Jiao
authors.affiliation: From the Departments of Medical Imaging (Q.X., Z.Z., W.L., L.X., Q.J., G.L.) zhangzq2001@126.com cjr.luguangming@vip.163.com.
authors.forename: G
authors.initials: G
authors.lastname: Lu
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged
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