title: Hypothalamic sidedness in mitochondrial metabolism: new perspectives.
abstract: Morphofunctional changes in hypothalamic neurons are highly energy dependent and rely on mitochondrial metabolism. Therefore, mitochondrial adenosine triphosphate production plays a permissive role in hypothalamic regulatory events. Here, we demonstrated that in the female rat hypothalamus, mitochondrial metabolism and tissue oxygenation show an asymmetric lateralization during the estrous cycle. This asymmetry was not detected in males. The observed sidedness suggests that estrous cycle-linked hypothalamic functions in females are based on hemispheric distinction. The novel concept of hypothalamic asymmetry necessitates the revision of hypothalamic neural circuits, synaptic reorganization, and the role of hypothalamic sides in the regulation of integrated homeostatic functions.
authors.affiliation: Department of Physiology and Biochemistry, Szent Istvan University Faculty of Veterinary Sciences, Budapest, Hungary.
authors.forename: Istvan
authors.initials: I
authors.lastname: Toth
authors.affiliation: Department of Physiology and Biochemistry, Szent Istvan University Faculty of Veterinary Sciences, Budapest, Hungary.
authors.forename: David Sandor
authors.initials: DS
authors.lastname: Kiss
authors.affiliation: Department of Physiology and Biochemistry, Szent Istvan University Faculty of Veterinary Sciences, Budapest, Hungary.
authors.forename: Greta
authors.initials: G
authors.lastname: Goszleth
authors.affiliation: Department of Physiology and Biochemistry, Szent Istvan University Faculty of Veterinary Sciences, Budapest, Hungary.
authors.forename: Tibor
authors.initials: T
authors.lastname: Bartha
authors.affiliation: Department of Physiology and Biochemistry, Szent Istvan University Faculty of Veterinary Sciences, Budapest, Hungary.
authors.forename: Laszlo V
authors.initials: LV
authors.lastname: Frenyo
authors.affiliation: Reproductive Biology Research, New York University, New York, NY, USA.
authors.forename: Frederick
authors.initials: F
authors.lastname: Naftolin
authors.affiliation: Division of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Tamas L
authors.initials: TL
authors.lastname: Horvath
authors.affiliation: Department of Physiology and Biochemistry, Szent Istvan University Faculty of Veterinary Sciences, Budapest, Hungary zsarnovszky.attila@aotk.szie.hu.
authors.forename: Attila
authors.initials: A
authors.lastname: Zsarnovszky
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D019069:Cell Respiration; D004734:Energy Metabolism; D004971:Estrus / Q000378:metabolism; D005260:Female; D006706:Homeostasis; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D010101:Oxygen Consumption; D017208:Rats, Wistar; D012737:Sex Factors
chemical_list: D000255:Adenosine Triphosphate
keywords: estrous cycle; hypothalamus; metabolic asymmetry; mitochondrial respiration; rat