title: Aerobic plus resistance training was more effective in improving the visceral adiposity, metabolic profile and inflammatory markers than aerobic training in obese adolescents.
abstract: The purpose of this study was to determine whether aerobic plus resistance training (AT + RT) is more effective than aerobic training (AT) at reducing inflammatory markers and cardiovascular risk in obese adolescents. A total of 139 obese adolescents were enrolled, aged 15-19 years, body mass index (BMI) ≥ 95th percentile and participated in 1 year of interdisciplinary intervention. They were randomised into two groups: AT (n = 55), AT + RT (n = 61). Blood samples were collected to analyse glycaemia, insulin, the lipid profile, leptin and adiponectin concentrations. Insulin resistance was measured by homeostasis model assessment of insulin resistance index (HOMA-IR). The AT + RT group showed better results with regard to decreased body fat mass, low-density lipoprotein concentration (LDL-c) levels, subcutaneous and visceral fat and increased body lean mass. Indeed, a reduction of hyperleptinaemia and an increase in adiponectin concentrations, promoting an improvement in the leptin/adiponectin ratio, was observed. Important clinical parameters were improved in both types of exercise; however, AT + RT was more effective in improving the visceral adiposity, metabolic profile and inflammatory markers than AT alone, suggesting clinical applications for the control of intra-abdominal obesity and cardiovascular risk in the paediatric population.
authors.affiliation: a Post Graduate Program of Nutrition , Universidade Federal de São Paulo , São Paulo , Brazil.
authors.forename: Ana Raimunda
authors.initials: AR
authors.lastname: Dâmaso
authors.forename: Raquel Munhoz
authors.initials: RM
authors.lastname: da Silveira Campos
authors.forename: Danielle Arisa
authors.initials: DA
authors.lastname: Caranti
authors.forename: Aline
authors.initials: A
authors.lastname: de Piano
authors.forename: Mauro
authors.initials: M
authors.lastname: Fisberg
authors.forename: Denis
authors.initials: D
authors.lastname: Foschini
authors.forename: Priscila
authors.initials: P
authors.lastname: de Lima Sanches
authors.forename: Lian
authors.initials: L
authors.lastname: Tock
authors.forename: Henrique Manoel
authors.initials: HM
authors.lastname: Lederman
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.forename: Marco Túlio
authors.initials: MT
authors.lastname: de Mello
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism; D052242:Adiponectin / Q000097:blood; D050154:Adiposity; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001825:Body Fluid Compartments / Q000378:metabolism; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D008078:Cholesterol, LDL / Q000097:blood; D015444:Exercise; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D020738:Leptin / Q000097:blood; D056128:Obesity, Abdominal / Q000097:blood / Q000378:metabolism / Q000628:therapy*; D063766:Pediatric Obesity / Q000097:blood / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D055070:Resistance Training; D050151:Subcutaneous Fat / Q000378:metabolism; D055815:Young Adult
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D008078:Cholesterol, LDL; D020738:Leptin
keywords: adolescents; exercise; obesity; visceral fat