title: Design, synthesis, docking and anti-inflammatory evaluation of novel series of benzofuran based prodrugs.
abstract: Several new benzofuran derivatives were synthesized, via appropriate synthetic route as anti-inflammatory agents. The anti-inflammatory activity of the prepared compounds was evaluated using carrageenan rat model. Among the synthesized compounds, some compounds showed comparable anti-inflammatory activity to nimesulide, the standard drug taken for anti-inflammatory studies. Docking study of the prepared compounds was performed for the study of interaction of molecules with the active site of COX-2. Preliminary biological studies and docking gave an interesting insight, into the validity of employing benzofuran analogues as good anti-inflammatory agent.
authors.affiliation: Department of Chemistry, Centre of Advance Studies, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India.
authors.forename: Pratima
authors.initials: P
authors.lastname: Yadav
authors.affiliation: Department of Chemistry, Centre of Advance Studies, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Singh
authors.affiliation: Department of Chemistry, Centre of Advance Studies, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India. Electronic address: tashish2002@yahoo.com.
authors.forename: Ashish Kumar
authors.initials: AK
authors.lastname: Tewari
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D015195:Drug Design; D008958:Models, Molecular; D062105:Molecular Docking Simulation; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D011355:Prodrugs
keywords: Anti-inflammatory; Benzofurans; Drug design; Inflammation; Molecular modeling