title: Bovine neonatal pancytopenia (BNP): novel insights into the incidence, vaccination-associated epidemiological factors and a potential genetic predisposition for clinical and subclinical cases.
abstract: Bovine neonatal pancytopenia (BNP) is a haemorrhagic disease of newborn calves elicited by colostrum from specific cows. Two studies have indicated that BNP-inducing colostrum might be associated with alloantibodies directed against MHC class I in response to vaccination with a distinct inactivated viral vaccine. However, the proportion of alloantibody-producing individuals by far exceeds the proportion of clinical BNP cases in the vaccinated population. This raises the question about the incidence of subclinical, unrecognised cases and also suggests further factors involved in BNP pathogenesis, e.g., genetic predisposition. Our results on neonatal calves from a closely monitored resource population confirmed the hypothesis of a genetic predisposition for clinical BNP and suggest that the predisposition is also involved in subclinical BNP-cases. No indication was obtained for a higher frequency of subclinical BNP-cases compared with clinical cases. Neither time point nor frequency of vaccination was a relevant factor for BNP in our resource population.
authors.affiliation: Research Unit Molecular Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Demasius
authors.affiliation: Research Unit Molecular Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Weikard
authors.affiliation: Research Unit Molecular Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Kromik
authors.affiliation: State Office for Agriculture, Food Safety and Fishery Mecklenburg-Western Pommerania (LALLF M-V), Thierfelderstraße 18, 18059 Rostock, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Wolf
authors.affiliation: Clinic for Ruminants and Swine, Department of Veterinary Medicine, Freie Universität Berlin, Königsweg 65, 14163 Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Müller
authors.affiliation: Research Unit Molecular Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany. Electronic address: kuehn@fbn-dummerstorf.de.
authors.forename: C
authors.initials: C
authors.lastname: Kühn
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001772:Blood Cell Count / Q000662:veterinary; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D015994:Incidence; D007518:Isoantibodies / Q000097:blood; D008297:Male; D010198:Pancytopenia / Q000453:epidemiology / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D010375:Pedigree; D011247:Pregnancy; D018709:Statistics, Nonparametric; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology*
chemical_list: D007518:Isoantibodies; D014765:Viral Vaccines
keywords: Bovine neonatal pancytopenia; Genetic predisposition; Haematology; Subclinical cases; Vaccination