title: Endogenous and exogenous electric fields as modifiers of brain activity: rational design of noninvasive brain stimulation with transcranial alternating current stimulation.
abstract: Synchronized neuronal activity in the cortex generates weak electric fields that are routinely measured in humans and animal models by electroencephalography and local field potential recordings. Traditionally, these endogenous electric fields have been considered to be an epiphenomenon of brain activity. Recent work has demonstrated that active cortical networks are surprisingly susceptible to weak perturbations of the membrane voltage of a large number of neurons by electric fields. Simultaneously, noninvasive brain stimulation with weak, exogenous electric fields (transcranial current stimulation, TCS) has undergone a renaissance due to the broad scope of its possible applications in modulating brain activity for cognitive enhancement and treatment of brain disorders. This review aims to interface the recent developments in the study of both endogenous and exogenous electric fields, with a particular focus on rhythmic stimulation for the modulation of cortical oscillations. The main goal is to provide a starting point for the use of rational design for the development of novel mechanism-based TCS therapeutics based on transcranial alternating current stimulation, for the treatment of psychiatric illnesses.
authors.affiliation: Department of Psychiatry, Department of Cell Biology and Physiology, Department of Biomedical Engineering, Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Flavio
authors.initials: F
authors.lastname: Fröhlich
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D006801:Humans; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D065908:Transcranial Direct Current Stimulation
keywords: feedback electric field; magnetic resonance imaging; neuronal network; transcranial alternating current stimulation
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