title: Evaluation of avibactam-supplemented combination disk tests for the detection of OXA-48 carbapenemase-producing Enterobacteriaceae.
abstract: The ability of various combination disk tests (CDTs) incorporating avibactam to detect OXA-48 carbapenemase-producing Enterobacteriaceae was evaluated. The CDT using 30-μg temocillin alone and supplemented with 5-μg avibactam showed good performance and could be an adjunctive test to the classic CDT containing class A and class B carbapenemase inhibitors for the positive discrimination of OXA-48 carbapenemase producers from carbapenemase-negative strains.
authors.affiliation: National Reference Laboratory for Monitoring of Antimicrobial Resistance in Gram-negative bacteria, CHU Dinant-Godinne|UCL Namur, 1 Avenue Dr. G. Therasse, 5530 Yvoir, Belgium. Electronic address: te-din.huang@uclouvain.be.
authors.forename: Te-Din
authors.initials: TD
authors.lastname: Huang
authors.affiliation: National Reference Laboratory for Monitoring of Antimicrobial Resistance in Gram-negative bacteria, CHU Dinant-Godinne|UCL Namur, 1 Avenue Dr. G. Therasse, 5530 Yvoir, Belgium.
authors.forename: Catherine
authors.initials: C
authors.lastname: Berhin
authors.affiliation: National Reference Laboratory for Monitoring of Antimicrobial Resistance in Gram-negative bacteria, CHU Dinant-Godinne|UCL Namur, 1 Avenue Dr. G. Therasse, 5530 Yvoir, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Bogaerts
authors.affiliation: National Reference Laboratory for Monitoring of Antimicrobial Resistance in Gram-negative bacteria, CHU Dinant-Godinne|UCL Namur, 1 Avenue Dr. G. Therasse, 5530 Yvoir, Belgium.
authors.forename: Youri
authors.initials: Y
authors.lastname: Glupczynski
mesh_terms: D000900:Anti-Bacterial Agents; D053961:Azabicyclo Compounds; D001431:Bacteriological Techniques / Q000379:methods*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000175:diagnosis / Q000382:microbiology; D006801:Humans; D010406:Penicillins; D001618:beta-Lactamases / Q000032:analysis*
chemical_list: D000900:Anti-Bacterial Agents; D053961:Azabicyclo Compounds; D010406:Penicillins; C031367:temocillin; C543519:avibactam; D001618:beta-Lactamases; C108449:oxacillinase
keywords: Inhibitor; OXA-type beta-lactamase; Temocillin