title: Ultrasound-microbubble transplantation of bone marrow stromal cells improves neurological function after forebrain ischemia in adult mice.
abstract: In this study, bone marrow stromal cells (MSCs) were transplanted into the brain of adult rats after forebrain ischemia induced by 4VO. SD rats (n = 60) were randomly divided into three groups: (I) rats (n = 20) were subjected to 4VO and transplanted with MSCs into the ischemic region using ultrasound-microbubble method, (2) rats (n = 20) were subjected to 4VO and transplanted with MSCs into the ischemic region (n = 20), and (3) 4VO alone (n = 20). Rats were sacrificed 28 days after treatment. Neurological functions of rats were evaluated by Morris Water Maze. The current findings suggest that the ultrasound microbubble transplanted MSCs survived in the ischemic brain and significantly improved functional recovery of adult rats compared to regular transplantation.
authors.affiliation: Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400000, China.
authors.forename: Zili
authors.initials: Z
authors.lastname: Gong
authors.forename: Hong
authors.initials: H
authors.lastname: Ran
authors.forename: Shengzheng
authors.initials: S
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.forename: Jian
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D018782:Maze Learning; D045164:Mesenchymal Stem Cell Transplantation; D045423:Microbubbles; D016548:Prosencephalon / Q000098:blood supply* / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D014159:Transducers; D014465:Ultrasonics