title: Bridging the gap between the human and macaque connectome: a quantitative comparison of global interspecies structure-function relationships and network topology.
abstract: Resting state functional connectivity MRI (rs-fcMRI) may provide a powerful and noninvasive "bridge" for comparing brain function between patients and experimental animal models; however, the relationship between human and macaque rs-fcMRI remains poorly understood. Here, using a novel surface deformation process for species comparisons in the same anatomical space (Van Essen, 2004, 2005), we found high correspondence, but also unique hub topology, between human and macaque functional connectomes. The global functional connectivity match between species was moderate to strong (r = 0.41) and increased when considering the top 15% strongest connections (r = 0.54). Analysis of the match between functional connectivity and the underlying anatomical connectivity, derived from a previous retrograde tracer study done in macaques (Markov et al., 2012), showed impressive structure-function correspondence in both the macaque and human. When examining the strongest structural connections, we found a 70-80% match between structural and functional connectivity matrices in both species. Finally, we compare species on two widely used metrics for studying hub topology: degree and betweenness centrality. The data showed topological agreement across the species, with nodes of the posterior cingulate showing high degree and betweenness centrality. In contrast, nodes in medial frontal and parietal cortices were identified as having high degree and betweenness in the human as opposed to the macaque. Our results provide: (1) a thorough examination and validation for a surface-based interspecies deformation process, (2) a strong theoretical foundation for making interspecies comparisons of rs-fcMRI, and (3) a unique look at topological distinctions between the species.
authors.affiliation: Department of Behavioral Neuroscience and Advanced Imaging Research Center, Oregon Health and Science University, Portland, Oregon 97239, Center for Neuroscience, University of California, Davis, California 95616, Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006, and Department of Biomedical Engineering, Tecnologico de Monterrey, Campus Monterrey, Nuevo Leon, Mexico 64849.
authors.forename: Oscar
authors.initials: O
authors.lastname: Miranda-Dominguez
authors.forename: Brian D
authors.initials: BD
authors.lastname: Mills
authors.forename: David
authors.initials: D
authors.lastname: Grayson
authors.forename: Andrew
authors.initials: A
authors.lastname: Woodall
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Grant
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Kroenke
authors.forename: Damien A
authors.initials: DA
authors.lastname: Fair
mesh_terms: D000328:Adult; D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000098:blood supply / Q000502:physiology*; D063132:Connectome; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology* / Q000098:blood supply; D010100:Oxygen / Q000097:blood; D012372:ROC Curve; D012044:Regression Analysis; D013045:Species Specificity; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: graph theory; macaque functional connectivity; network topology; resting state functional connectivity MRI; structure function relationships
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