title: A chiral benzoylthiourea-pyrrolidine catalyst for the highly enantioselective Michael addition of ketones to chalcones.
abstract: A benzoylthiourea-pyrrolidine catalyst was developed for the asymmetric Michael addition of ketones to chalcones. The corresponding products were obtained in high yields with high level of diastereoselectivities (up to 99:1 dr) and high level of enantioselectivities (up to 94% ee) under mild conditions.
authors.affiliation: School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, People's Republic of China; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada. Electronic address: shurong.ban@mcgill.ca.
authors.forename: Shu-Rong
authors.initials: SR
authors.lastname: Ban
authors.affiliation: School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, People's Republic of China.
authors.forename: Xi-Xia
authors.initials: XX
authors.lastname: Zhu
authors.affiliation: School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, People's Republic of China.
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, People's Republic of China. Electronic address: qingshanl@yahoo.com.
authors.forename: Qing-Shan
authors.initials: QS
authors.lastname: Li
mesh_terms: D002384:Catalysis; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D008968:Molecular Conformation; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D047188:Chalcones; D007659:Ketones; D011759:Pyrrolidines; D013890:Thiourea; C032519:pyrrolidine
keywords: Benzoylthiourea–pyrrolidine; Chalcones; Enantioselective; Ketones; Michael addition