title: Diurnal variation of haemostatic response to exercise in young sedentary males.
abstract: The aim of this study was to evaluate diurnal variations in the haemostatic response to submaximal exercise performed by young, sedentary men. Fifteen healthy young sedentary males aged 25.6 ± 1.34 (mean ± SD) years performed two exercise sessions, morning and evening, at 70% of maximal oxygen consumption ([Formula: see text]O2max) on a cycle ergometer for 30 min. Platelet count (PC), activated partial thromboplastin time (aPTT), prothrombin time (PT), fibrinogen, tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) activity were measured as dependent variables. Exercise produced significant increases in PC and fibrinogen for both sessions (P ≤ 0.05), which returned to the resting values after recovery only in the evening session. APTT and PT shortened immediately after exercise, which remained after recovery for both sessions (P ≤ 0.01). Exercise presented significant increases in tPA activity (P ≤ 0.001), which returned to the baseline after recovery in both exercises. PAI-1 activity was significantly higher during the morning than evening (P ≤ 0.05), but no longer demonstrated exercise-related changes. It was found that exercise caused activation of both coagulation and fibrinolysis processes, partly related to the time of the day when the exercise was performed.
authors.affiliation: Department of Physical Education & Sport Sciences, University of Mohaghegh Ardabili, Ardabil, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Siahkouhian
authors.affiliation: Department of Physical Education & Sport Sciences, University of Mohaghegh Ardabili, Ardabil, Iran.
authors.forename: D
authors.initials: D
authors.lastname: Khodadadi
authors.affiliation: Department of Physical Education & Sport Sciences, University of Mohaghegh Ardabili, Ardabil, Iran.
authors.forename: L
authors.initials: L
authors.lastname: Bolboli
keywords: coagulation; diurnal variation; fibrinolysis; thrombus
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