title: Diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT: a clinical follow up study.
abstract: The [(123)I]ioflupane-a dopamine transporter radioligand-SPECT (DaT-SPECT) has proven to be useful in the differential diagnosis of tremor. Here, we investigate the diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT. Therefore, 30 patients with tremor and normal DaT-SPECT were followed up for 2 years. In 18 cases we were able to make a diagnosis. The residual 12 patients underwent a second DaT-SPECT, were then followed for additional 12 months and thereafter the diagnosis was reconsidered again. The final diagnoses included cases of essential tremor, dystonic tremor, multisystem atrophy, vascular parkinsonism, progressive supranuclear palsy, corticobasal degeneration, fragile X-associated tremor ataxia syndrome, psychogenic parkinsonism, iatrogenic parkinsonism and Parkinson's disease. However, for 6 patients the diagnosis remained uncertain. Larger series are needed to better establish the relative frequency of the different conditions behind these cases.
authors.affiliation: Neurology Unit, Hospital Álvarez-Buylla Mieres, Spain ; Morphology and Cellular Biology Department, Universidad de Oviedo Oviedo, Spain ; Instituto de Neurociencias, Universidad de Oviedo Oviedo, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Menéndez-González
authors.affiliation: Family Medicine, Hospital Álvarez-Buylla Mieres, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Tavares
authors.affiliation: Nuclear Medicine, Hospital Universitario Central de Asturias Oviedo, Spain.
authors.forename: Nahla
authors.initials: N
authors.lastname: Zeidan
authors.affiliation: Instituto de Investigación Científica, Universidad Juárez del Estado de Durango Durango, Mexico.
authors.forename: José M
authors.initials: JM
authors.lastname: Salas-Pacheco
authors.affiliation: Transcranial Magnetic Stimulation Unit, Sleep and Movement Disorders Clinic, Hospital General Dr. Manuel Gea González Mexico City, Mexico.
authors.forename: Oscar
authors.initials: O
authors.lastname: Arias-Carrión
keywords: DaTSPECT; Movement Disorders; Parkinson disease; SWEDD; tremor
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