title: Molecular imaging of macrophage enzyme activity in cardiac inflammation.
abstract: Molecular imaging is highly advantageous as various insidious inflammatory events can be imaged in a serial and quantitative fashion. Combined with the conventional imaging modalities like computed tomography (CT), magnetic resonance (MR) and nuclear imaging, it helps us resolve the extent of ongoing pathology, quantify inflammation and predict outcome. Macrophages are increasingly gaining importance as an imaging biomarker in inflammatory cardiovascular diseases. Macrophages, recruited to the site of injury, internalize necrotic or foreign material. Along with phagocytosis, activated macrophages release proteolytic enzymes like matrix metalloproteinases (MMPs) and cathepsins into the extracellular environment. Pro-inflammatory monocytes and macrophages also induce tissue oxidative damage through the inflammatory enzyme myeloperoxidase (MPO). In this review we will highlight recent advances in molecular macrophage imaging. Particular stress will be given to macrophage functional and enzymatic activity imaging which targets phagocytosis, proteolysis and myeloperoxidase activity imaging.
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), 185 Cambridge Street, Boston, MA 02114.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ali
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), 185 Cambridge Street, Boston, MA 02114.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Pulli
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), 185 Cambridge Street, Boston, MA 02114 ; Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114.
authors.forename: John W
authors.initials: JW
authors.lastname: Chen
keywords: Molecular imaging; atherosclerosis; cardiovascular; enzyme activity; inflammation; macrophage; myeloperoxidase; myocardial infarction; phagocytes; protease; transplant rejection
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