title: Prognostic factors of quality of life after transoral laser microsurgery for laryngeal cancer.
abstract: We aimed to evaluate factors influencing quality of life (QOL) after transoral laser microsurgery (TLM) of laryngeal cancer. Four hundred and one consecutive disease-free patients were evaluated 1 year after treatment using the University of Washington-QOL v4, the SF-12 (short form of SF-36), and a questionnaire about self-rated health status. The importance of age, gender, tumor location, tumor size, tumor stage, neck dissection and adjuvant treatment were evaluated. One year after TLM patients had a good QOL, with only 6 % of patients reporting a worsening in their health status. Radiation therapy (p = 0.000) and neck dissection (p = 0.000) were negative factors for disease-specific QOL, whereas age ≥ 70 (p = 0.01) was a positive independent factor for mental score of SF-12. Speech was negatively influenced by tumor size (p = 0.001) as was swallowing by age (p = 0.001) and postoperative radiation (p = 0.000). Patients treated with TLM present a good QOL 1 year after surgery. Radiation and neck dissection negatively impact QOL. Elderly patients cope better with their disabilities.
authors.affiliation: Department of Otorhinolaryngology, Hospital Clínic, c/Villarroel 170, 08036, Barcelona, Spain, ivila@clinic.ub.es.
authors.forename: Isabel
authors.initials: I
authors.lastname: Vilaseca
authors.forename: Manuel
authors.initials: M
authors.lastname: Bernal-Sprekelsen
authors.forename: Ruth
authors.initials: R
authors.lastname: Him
authors.forename: Alexandra
authors.initials: A
authors.lastname: Mandry
authors.forename: Eduardo
authors.initials: E
authors.lastname: Lehrer
authors.forename: José Luis
authors.initials: JL
authors.lastname: Blanch
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000523:psychology / Q000601:surgery; D003680:Deglutition Disorders / Q000209:etiology / Q000523:psychology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000523:psychology / Q000601:surgery; D053685:Laser Therapy / Q000379:methods / Q000523:psychology; D008297:Male; D008866:Microsurgery / Q000379:methods / Q000523:psychology; D008875:Middle Aged; D037981:Neck Dissection / Q000009:adverse effects* / Q000379:methods / Q000523:psychology; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000523:psychology*; D011379:Prognosis; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects* / Q000379:methods / Q000523:psychology; D013064:Speech Disorders / Q000209:etiology / Q000523:psychology; D011795:Surveys and Questionnaires; D047368:Tumor Burden
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