title: Association of butyrylcholinesterase with cardiometabolic risk factors among apparently healthy adults.
abstract: BACKGROUND
  Although butyrylcholinesterase is widely distributed in different tissues of the human body, its physiological role has not yet been defined. This study aimed to explore the relationship between butyrylcholinesterase and lipids levels, among apparently healthy adults.
  
  
  METHODS
  During 2009, 490 volunteers (46 ± 16 years, 40% men) who visited the outpatients' office of our hospital for routine examinations were consecutively enrolled in the study (participation rate 85%). Biochemical analyses were performed through established procedures, after 12 h fasting, and haematological as well as biochemical parameters were measured. Anthropometric, lifestyle and dietary characteristics were also recorded to account for potential confounding.
  
  
  RESULTS
  Butyrylcholinesterase activity was positively correlated with glucose, low-density lipoprotein (LDL)-cholesterol, total cholesterol, triglycerides, uric acid, haptoglobin and platelet count, after age-sex adjustments (all Ps < 0.05). Further adjustment for a series of anthropometric, lifestyle and clinical characteristics revealed that only BMI, LDL-cholesterol, total cholesterol and triglycerides were positively associated with serum butyrylcholinesterase activity.
  
  
  CONCLUSIONS
  This study demonstrated the positive association of serum butyrylcholinesterase activity with BMI, LDL-cholesterol, total cholesterol and triglycerides, a fact that could state a hypothesis for a novel marker of atherosclerotic disease that could - together with other biomarkers - improve our potential to assess cardiovascular disease risk.
authors.affiliation: aPolykliniki General Hospital, Athens bDepartment of Nutrition and Dietetics, Harokopio University of Athens, Greece.
authors.forename: Natalia G
authors.initials: NG
authors.lastname: Vallianou
authors.forename: Angelos A
authors.initials: AA
authors.lastname: Evangelopoulos
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Bountziouka
authors.forename: Maria S
authors.initials: MS
authors.lastname: Bonou
authors.forename: Christina
authors.initials: C
authors.lastname: Katsagoni
authors.forename: Evangelos D
authors.initials: ED
authors.lastname: Vogiatzakis
authors.forename: Petros C
authors.initials: PC
authors.lastname: Avgerinos
authors.forename: John
authors.initials: J
authors.lastname: Barbetseas
authors.forename: Demosthenes B
authors.initials: DB
authors.lastname: Panagiotakos
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002091:Butyrylcholinesterase / Q000097:blood*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology; D005260:Female; D006115:Greece / Q000453:epidemiology; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D008019:Life Style; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis / Q000201:enzymology / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D010976:Platelet Count; D015995:Prevalence; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; C485359:HP protein, human; D006242:Haptoglobins; D008055:Lipids; D014527:Uric Acid; D002091:Butyrylcholinesterase