title: [A case of curatively resected sigmoid colon cancer after mFOLFOX6 plus panitumumab neoadjuvant chemotherapy].
abstract: A 54-year-old man with residual urine, abdominal pain, and a high fever was diagnosed with KRAS wild-type sigmoid colon cancer with urinary bladder invasion. Considering the difficulty of curative resection, we first performed an ileostomy. Remarkable tumor regression was indicated by computed tomography(CT)and colonoscopy after 3 courses of mFOLFOX6 plus panitumumab. A sigmoidectomy and partial cystectomy were performed with a curative intent. Six courses of XELOX adjuvant chemotherapy were administered, and no recurrence has been observed for 9 months. mFOLFOX6 plus panitumumab might be an effective preoperative chemotherapy for patients with locally advanced KRAS wild-type colon cancer.
authors.affiliation: Dept. of General Surgery, Neyagawa Ikuno Hospital.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kuwata
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Nakahata
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077544:Panitumumab; D012811:Sigmoid Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D000911:Antibodies, Monoclonal; D009944:Organoplatinum Compounds; D000077544:Panitumumab; D002955:Leucovorin; D005472:Fluorouracil