title: Alzheimer disease: An interactome of many diseases.
abstract: Alzheimer Disease (AD) is an outcome as well as source of many diseases. Alzheimer is linked with many other diseases like Diabetes type 2, cholesterolemia, hypertension and many more. But how each of these diseases affecting other is still unknown to scientific community. Signaling Pathways of one disease is interlinked with other disease. But to what extent healthy brain is affected when any signaling in human body is disturbed is the question that matters. There is a need of Pathway analysis, Protein-Protein interaction (PPI) and the conserved interactome study in AD and linked diseases. It will be helpful in finding the potent drug or vaccine target in conscious manner. In the present research the Protein-Protein interaction of all the proteins involved in Alzheimer Disease is analyzed using ViSANT and osprey tools and pathway analysis further reveals the significant genes/proteins linking AD with other diseases.
authors.affiliation: Department of Bioinformatics, NTHRYS Biotech Labs, Hyderabad, Andhra Pradesh, India.
authors.forename: Balaji S
authors.initials: BS
authors.lastname: Rao
authors.affiliation: Department of Bioinformatics, NTHRYS Biotech Labs, Hyderabad, Andhra Pradesh, India.
authors.forename: Krishna Kant
authors.initials: KK
authors.lastname: Gupta
authors.affiliation: Department of Bioinformatics, NTHRYS Biotech Labs, Hyderabad, Andhra Pradesh, India.
authors.forename: Pujitha
authors.initials: P
authors.lastname: Karanam
authors.affiliation: Department of Bioinformatics, NTHRYS Biotech Labs, Hyderabad, Andhra Pradesh, India.
authors.forename: Anusha
authors.initials: A
authors.lastname: Peruri
keywords: Alzheimer disease; centrality; gene set enrichment analysis; network analysis; protein-protein interactions; reactive oxygen species; string
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