title: Functionally defective high-density lipoproteins are related to heightened T-cell activation in vertically HIV-infected adolescents.
abstract: We assessed high-density lipoprotein (HDL) anti-inflammatory properties in a cohort of vertically HIV-infected adolescents. We hypothesized that proatherogenic mechanisms related to inflammation and immune activation during HIV infection may impair HDL functionality and impact on the atherosclerotic burden. Compared with healthy controls, HDL from HIV-infected adolescents presented impaired functionality, as determined by its ability to inhibit monocyte chemotaxis in vitro, which correlated with detectable viral loads (P = 0.044), lower CD4 nadir (P = 0.043), increased levels of CD4 T-cell activation (P = 0.018), higher C-reactive protein (P = 0.009), and a tendency toward thicker carotid intima-media thickness (P = 0.071).
authors.affiliation: *Laboratorio de InmunoBiología Molecular, Department of Pediatrics, Instituto de Investigación Sanitaria Hospital General Universitario Gregorio Marañón (IiSGM), Servicio de Pediatría e Instituto de Investigación Sanitaria Hospital Gregorio Marañón, Madrid, Spain; †Laboratorio de Vascular, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain; ‡Department of Infectious Diseases, Servicio de Enfermedades Infecciosas e IRYCIS, Hospital Universitario Ramón y Cajal, and IRYCIS, Madrid, Spain; §Department of Pediatrics, Servicio de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, Spain; ‖Department of Pediatrics, Unidad de Inmunodeficiencias pediátricas, Servicio de Pediatría, Hospital Universitario Doce de Octubre, Madrid, Spain; ¶Department of Pediatrics, Servicio de Pediatría, Hospital de Getafe, Madrid, Spain; #Department of Pediatrics, Servicio de Pediatría, Hospital Carlos III, Madrid, Spain; **Department of Internal Medicine, Servicio de Medicina Interna, Hospital Clínico San Carlos, Madrid, Spain; and ††Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.
authors.forename: Talía
authors.initials: T
authors.lastname: Sainz
authors.forename: Adriana
authors.initials: A
authors.lastname: Ortega-Hernández
authors.forename: Sergio
authors.initials: S
authors.lastname: Serrano-Villar
authors.forename: María L
authors.initials: ML
authors.lastname: Navarro
authors.forename: Pablo
authors.initials: P
authors.lastname: Rojo
authors.forename: José T
authors.initials: JT
authors.lastname: Ramos
authors.forename: María J
authors.initials: MJ
authors.lastname: Mellado
authors.forename: Laura
authors.initials: L
authors.lastname: Diaz
authors.forename: Maria
authors.initials: M
authors.lastname: Alvarez
authors.forename: Vicente
authors.initials: V
authors.lastname: Estrada
authors.forename: Dulcenombre
authors.initials: D
authors.lastname: Gómez-Garre
authors.forename: María A
authors.initials: MA
authors.lastname: Muñoz-Fernández
mesh_terms: D000293:Adolescent; D002097:C-Reactive Protein / Q000378:metabolism; D018791:CD4 Lymphocyte Count; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D002633:Chemotaxis / Q000502:physiology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D006801:Humans; D008075:Lipoproteins, HDL / Q000502:physiology*; D008213:Lymphocyte Activation; D008297:Male; D009000:Monocytes / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D019562:Viral Load
chemical_list: D008075:Lipoproteins, HDL; D002097:C-Reactive Protein