title: A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3.
abstract: One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O-α-l-rhamnopyranoside (1), together with one known α-dibenzopyrone, alternariol (2), and five xanthones (3-7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1-7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 exhibited moderate COX-2 inhibition, with IC50 values of 12.2 μM.
authors.affiliation: a CAS Key Laboratory of Tropical Marine Bio-resources and Ecology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Wang
authors.forename: Fu-Quan
authors.initials: FQ
authors.lastname: Xu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.forename: Jun-Ting
authors.initials: JT
authors.lastname: Wan
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Zhou
authors.forename: Tian-Yu
authors.initials: TY
authors.lastname: Zhang
authors.forename: Zheng-Chao
authors.initials: ZC
authors.lastname: Tu
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000382:microbiology*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C000592644:1,8-dihydroxynaphthol-1-O-alpha-rhamnopyranoside; D052246:Cyclooxygenase 2 Inhibitors; D006027:Glycosides; D009284:Naphthols; D044004:Xanthones
keywords: Arthrinium sp.; naphthalene glycoside; secondary metabolite; sponge