title: Relationship of vaspin and apelin levels with insulin resistance and atherosclerosis in metabolic syndrome.
abstract: OBJECTIVE
  We aimed to investigate, circulating vaspin, apelin-12 and apelin-36 levels in subjects with metabolic syndrome (MetS) and also to search for the association of vaspin and apelin levels with insulin resistance (IR), high sensitivity C-reactive protein (HsCRP), Carotid Artery Intima-Media Thickness (CIMT) and cardiovascular risk factors.
  
  
  METHODS
  In this observational case-control study, a total of forty one patients with MetS (30 women and 11 men mean age, 41.3±9.4 years) and thirty nine healthy comparison subjects (27 women and 12 men; mean age, 38.4±6.1 years) were enrolled. Serum HsCRP, lipid profile, insulin levels and the homeostasis model assessment of insulin resistance (HOMA-IR) were evaluated. Apelin-12, apelin-36 and vaspin serum levels were measured via ELISA. High-resolution B-mode ultrasonography was performed.
  
  
  RESULTS
  The two study groups did not differ as to age, sex, blood pressure, smoking history. Vaspin, apelin-12 and apelin-36 levels were significantly elevated in patients with MetS when compared with that of control subjects (P<0.001). Serum vaspin levels showed a statistically significant association with CIMT (r=0.365, P<0.001) and HsCRP (r=0.316, P<0.01) levels, whereas both serum apelin-12 and 36 levels were positively correlated with HOMA-IR (r=0.344/0.462 P<0.01).
  
  
  CONCLUSIONS
  Based on the findings of this study, Serum vaspin and apelin levels were found significantly higher in patients with MetS than age-matched control subjects and significantly associated with coronary atherosclerosis. These adipocytokines might play a part in the pathogenesis of MetS. Also serum Apelin levels can be used as specific markers for insulin sensitivity in patients with MetS.
authors.affiliation: Department of Endocrinology and Metabolism Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey - b_karbek@yahoo.com.
authors.forename: B
authors.initials: B
authors.lastname: Karbek
authors.forename: N C
authors.initials: NC
authors.lastname: Bozkurt
authors.forename: O
authors.initials: O
authors.lastname: Topaloglu
authors.forename: M S
authors.initials: MS
authors.lastname: Aslan
authors.forename: A
authors.initials: A
authors.lastname: Gungunes
authors.forename: E
authors.initials: E
authors.lastname: Cakal
authors.forename: T
authors.initials: T
authors.lastname: Delibasi
mesh_terms: D054392:Adipokines / Q000097:blood; D000328:Adult; D000073861:Apelin; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology; D015843:Serpins / Q000097:blood*
chemical_list: C115436:APLN protein, human; D054392:Adipokines; D000073861:Apelin; D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; C507339:SERPINA12 protein, human; D015842:Serine Proteinase Inhibitors; D015843:Serpins; C495200:apelin-12 peptide; D002097:C-Reactive Protein