title: Prognostic significance of cyclin D1 expression in colorectal cancer: a meta-analysis of observational studies.
abstract: OBJECTIVE
  Cyclin D1 plays a vital role in cancer cell cycle progression and is overexpressed in many human cancers, including colorectal cancer (CRC). However, the prognostic value of cyclin D1 overexpression in colorectal cancer is conflicting and heterogeneous. We conducted a meta-analysis to more precisely evaluate its prognostic significance.
  
  
  METHODS
  A comprehensive literature search for relevant studies published up to January 2014 was performed using PubMed, EMBASE, and ISI Web of Science. The pooled hazard ratio (HR) with 95% confidence intervals (CI) was used to estimate the effects.
  
  
  RESULTS
  22 studies with 4150 CRC patients were selected to evaluate the association between cyclin D1 and overall survival (OS), disease-free survival (DFS) and clinicopathological parameters. In a random-effects model, the results showed that cyclin D1 overexpression in CRC was significantly associated with both poor OS (HR = 0.73, 95% CI: 0.63-0.85, P<0.001) and DFS (HR = 0.60, 95% CI: 0.44-0.82, P = 0.001). Additionally, cyclin D1 overexpression was significantly associated with more relative older patients (≥ 60 years) (OR 0.62, 95% CI 0.44-0.89, P = 0.009), T3,4 tumor invasion (OR 0.70, 95% CI 0.57-0.85, P<0.001), N positive (OR 0.75, 95% CI 0.60-0.95, P = 0.016) and distant metastasis (OR 0.60, 95% CI 0.36-0.99, P = 0.047) of CRC.
  
  
  CONCLUSIONS
  The meta-analysis results indicated that cyclin D1 is an unfavorable prognostic factor for CRC. Cyclin D1 overexpression might be associated with poor clinical outcome and some clinicopathological factors such as age, T category, N category and distant metastasis in CRC patients.
authors.affiliation: Department of General surgery, East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of General surgery, East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Radiology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Chuanhui
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of General surgery, East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Zhongxin
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of General surgery, East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Tiangeng
authors.initials: T
authors.lastname: You
mesh_terms: D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1 / Q000378:metabolism*; D018572:Disease-Free Survival; D006801:Humans; D064887:Observational Studies as Topic; D011379:Prognosis; D016016:Proportional Hazards Models; D017594:Publication Bias
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1
references.citation: Dig Dis Sci. 2007 Sep;52(9):2305-11
references.pmid: 17393321
references.citation: Eur J Cancer. 1998 Sep;34(10):1575-81
references.pmid: 9893631
references.citation: Oncogene. 1995 Jun 1;10(11):2125-34
references.pmid: 7784057
references.citation: J Surg Oncol. 2013 Feb;107(2):148-54
references.pmid: 22926658
references.citation: BMC Gastroenterol. 2004 Sep 23;4:22
references.pmid: 15385053
references.citation: Pathol Oncol Res. 2000;6(1):65-70
references.pmid: 10749591
references.citation: Int J Cancer. 2000 Oct 1;88(1):77-81
references.pmid: 10964085
references.citation: Gastroenterology. 1996 Mar;110(3):669-74
references.pmid: 8608874
references.citation: Int J Colorectal Dis. 2009 Aug;24(8):875-84
references.pmid: 19421758
references.citation: Breast Cancer Res Treat. 2013 Jun;139(2):329-39
references.pmid: 23670132
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120
references.citation: Mol Med Rep. 2008 Jan-Feb;1(1):27-32
references.pmid: 21479373
references.citation: Cell. 1994 Nov 18;79(4):573-82
references.pmid: 7954824
references.citation: Dis Esophagus. 2012 Aug;25(6):520-6
references.pmid: 22098104
references.citation: Br J Cancer. 2010 Jun 8;102(12):1762-8
references.pmid: 20485284
references.citation: Int J Colorectal Dis. 2011 Jan;26(1):29-35
references.pmid: 21079973
references.citation: Dis Colon Rectum. 2005 Dec;48(12):2197-208
references.pmid: 16400510
references.citation: Science. 1992 Oct 16;258(5081):424-9
references.pmid: 1411535
references.citation: Oncology. 2001;61(3):226-33
references.pmid: 11574779
references.citation: Tumour Biol. 2013 Aug;34(4):2169-74
references.pmid: 23558963
references.citation: J Med. 1997;28(5-6):285-309
references.pmid: 9604788
references.citation: Prog Cardiovasc Dis. 1985 Mar-Apr;27(5):335-71
references.pmid: 2858114
references.citation: Lancet. 2005 Jan 8-14;365(9454):153-65
references.pmid: 15639298
references.citation: Trials. 2007 Jun 07;8:16
references.pmid: 17555582
references.citation: CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29
references.pmid: 22237781
references.citation: Res Commun Mol Pathol Pharmacol. 1999;105(3):237-52
references.pmid: 10954128
references.citation: J Pathol. 1996 Sep;180(1):1-5
references.pmid: 8943807
references.citation: Ann Surg Oncol. 2012 Jul;19 Suppl 3:S682-92
references.pmid: 22311118
references.citation: Dis Colon Rectum. 2001 Apr;44(4):523-33
references.pmid: 11330579
references.citation: Transl Oncol. 2012 Oct;5(5):370-8
references.pmid: 23066445
references.citation: World J Gastroenterol. 2010 Feb 28;16(8):960-5
references.pmid: 20180234
references.citation: J Cancer Res Clin Oncol. 1996;122(2):122-6
references.pmid: 8576279
references.citation: Clin Cancer Res. 2006 Feb 15;12(4):1184-91
references.pmid: 16489072
references.citation: Br J Cancer. 1996 Feb;73(3):294-300
references.pmid: 8562333
references.citation: Int J Cancer. 1994 Aug 15;58(4):568-73
references.pmid: 8056453
references.citation: J Pathol. 2002 Apr;196(4):386-93
references.pmid: 11920733
references.citation: Ann Surg Oncol. 2004 Nov;11(11):955-61
references.pmid: 15525823
references.citation: Pathol Res Pract. 2001;197(10):683-9
references.pmid: 11700890
references.citation: Clin Cancer Res. 2009 Jul 1;15(13):4431-8
references.pmid: 19549773
references.citation: Int J Cancer. 1997 Jun 20;74(3):310-5
references.pmid: 9221810
references.citation: Dev Cell. 2008 Feb;14(2):159-69
references.pmid: 18267085
references.citation: Eur J Surg Oncol. 2005 Sep;31(7):721-6
references.pmid: 15993030
references.citation: Int J Cancer. 2001 Sep 20;95(5):302-6
references.pmid: 11494229
references.citation: J Clin Pathol. 2005 May;58(5):509-14
references.pmid: 15858123
references.citation: Virchows Arch. 2000 Mar;436(3):224-8
references.pmid: 10782880