title: Analytical studies on the charge transfer complexes of loperamide hydrochloride and trimebutine drugs. Spectroscopic and thermal characterization of CT complexes.
abstract: Charge transfer complexes of loperamide hydrochloride (LOP.HCl) and trimebutine (TB) drugs as electron donor with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), tetracyanoethylene (TCNE) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as π-acceptors in acetonitrile were investigated spectrophotometrically to determine the cited drugs in pure and dosage forms. The reaction gives highly coloured complex species which are measured spectrophotometrically at 460, 415 and 842nm in case of LOP.HCl and at 455, 414 and 842nm in case of TB using DDQ, TCNE and TCNQ reagents, respectively. The optimum experimental conditions have been studied carefully and optimized. Beer's law was obeyed over the concentration ranges of 47.70-381.6, 21.50-150.5 and 10.00-100.0μgmL(-1) for LOP.HCl and 37.85-264.9, 38.75-310.0 and 7.75-155.0μgmL(-1) for TB using DDQ, TCNE and TCNQ reagents, respectively. Sandell sensitivity, standard deviation, relative standard deviation, limit of detection and quantification were calculated. The obtained data refer to high accuracy and precision of the proposed method. These results are also confirmed by inter and intra-day precision with percent recovery of 99.18-101.1% and 99.32-101.4% in case of LOP.HCl and 98.00-102.0% and 97.50-101.4% in case of TB using DDQ, TCNE and TCNQ reagents for intra- and inter-day, respectively. These data were compared with those obtained using official methods for the determination of the cited drugs. The stability constants of the CT complexes were determined. The final products of the reaction were isolated and characterized using FT-IR, (1)H NMR, elemental analysis and thermogravimetric analysis (TG). The stoichiometry and apparent formation constant of the complexes formed were determined by applying the conventional spectrophotometric molar ratio method.
authors.affiliation: National Organization for Drug Control and Research (NODCAR), Pyramid Ave., P.O. 29, Cairo, Egypt.
authors.forename: Hoda M
authors.initials: HM
authors.lastname: Elqudaby
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, 12613 Giza, Egypt. Electronic address: ggenidy@hotmail.com.
authors.forename: Gehad G
authors.initials: GG
authors.lastname: Mohamed
authors.affiliation: National Organization for Drug Control and Research (NODCAR), Pyramid Ave., P.O. 29, Cairo, Egypt.
authors.forename: Ghada M G
authors.initials: GM
authors.lastname: El-Din
mesh_terms: D005765:Gastrointestinal Agents / Q000032:analysis*; D007202:Indicators and Reagents; D057230:Limit of Detection; D008139:Loperamide / Q000032:analysis*; D013053:Spectrophotometry / Q000379:methods*; D013057:Spectrum Analysis; D013818:Thermogravimetry; D014287:Trimebutine / Q000032:analysis*
chemical_list: D005765:Gastrointestinal Agents; D007202:Indicators and Reagents; D008139:Loperamide; D014287:Trimebutine
keywords: CT complexes; Loperamide hydrochloride; Spectrophotometry; Spectroscopy; Trimebutine; π-Acceptors