title: Efficacy of three different regimens of primaquine for the prevention of relapses of Plasmodium vivax malaria in the Amazon Basin of Peru.
abstract: We evaluated the efficacy of three primaquine (PQ) regimes to prevent relapses with Plasmodium vivax through an open-label randomized trial in Loreto, Peru. Vivax monoinfections were treated with chloroquine for 3 days and PQ in three different regimes: 0.5 mg/kg per day for 5 days (150 mg total), 0.5 mg/kg per day for 7 days (210 mg total), or 0.25 mg/kg per day for 14 days (210 mg total). Biweekly fever assessments and bimonthly thick smears were taken for 210 days. Recurrences after 35 days were considered relapses. One hundred eighty cases were enrolled in each group; 90% of cases completed follow-up. There were no group-related differences in age, sex, or parasitemia. Relapse rates were similar in the 7- and 14-day regimes (16/156 = 10.3% and 22/162 = 13.6%, P = 0.361) and higher in the 5-day group (48/169 = 28.4%, P < 0.001 and P = 0.001, respectively). The 7-day PQ regimen used in Peru is as efficacious as the recommended 14-day regimen and superior to 5 treatment days.
authors.affiliation: US Naval Medical Research Unit No. 6 (NAMRU-6), Lima and Iquitos, Peru; Instituto Nacional de Salud, Lima, Peru; Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru; Direccion Regional de Salud Loreto, Iquitos, Peru; US Naval Medical Center San Diego, San Diego, California salomondurand@gmail.com.
authors.forename: Salomón
authors.initials: S
authors.lastname: Durand
authors.affiliation: US Naval Medical Research Unit No. 6 (NAMRU-6), Lima and Iquitos, Peru; Instituto Nacional de Salud, Lima, Peru; Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru; Direccion Regional de Salud Loreto, Iquitos, Peru; US Naval Medical Center San Diego, San Diego, California.
authors.forename: Cesar
authors.initials: C
authors.lastname: Cabezas
authors.affiliation: US Naval Medical Research Unit No. 6 (NAMRU-6), Lima and Iquitos, Peru; Instituto Nacional de Salud, Lima, Peru; Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru; Direccion Regional de Salud Loreto, Iquitos, Peru; US Naval Medical Center San Diego, San Diego, California.
authors.forename: Andres G
authors.initials: AG
authors.lastname: Lescano
authors.affiliation: US Naval Medical Research Unit No. 6 (NAMRU-6), Lima and Iquitos, Peru; Instituto Nacional de Salud, Lima, Peru; Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru; Direccion Regional de Salud Loreto, Iquitos, Peru; US Naval Medical Center San Diego, San Diego, California.
authors.forename: Mariela
authors.initials: M
authors.lastname: Galvez
authors.affiliation: US Naval Medical Research Unit No. 6 (NAMRU-6), Lima and Iquitos, Peru; Instituto Nacional de Salud, Lima, Peru; Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru; Direccion Regional de Salud Loreto, Iquitos, Peru; US Naval Medical Center San Diego, San Diego, California.
authors.forename: Sonia
authors.initials: S
authors.lastname: Gutierrez
authors.affiliation: US Naval Medical Research Unit No. 6 (NAMRU-6), Lima and Iquitos, Peru; Instituto Nacional de Salud, Lima, Peru; Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru; Direccion Regional de Salud Loreto, Iquitos, Peru; US Naval Medical Center San Diego, San Diego, California.
authors.forename: Nancy
authors.initials: N
authors.lastname: Arrospide
authors.affiliation: US Naval Medical Research Unit No. 6 (NAMRU-6), Lima and Iquitos, Peru; Instituto Nacional de Salud, Lima, Peru; Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru; Direccion Regional de Salud Loreto, Iquitos, Peru; US Naval Medical Center San Diego, San Diego, California.
authors.forename: Carlos
authors.initials: C
authors.lastname: Alvarez
authors.affiliation: US Naval Medical Research Unit No. 6 (NAMRU-6), Lima and Iquitos, Peru; Instituto Nacional de Salud, Lima, Peru; Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru; Direccion Regional de Salud Loreto, Iquitos, Peru; US Naval Medical Center San Diego, San Diego, California.
authors.forename: Meddly L
authors.initials: ML
authors.lastname: Santolalla
authors.affiliation: US Naval Medical Research Unit No. 6 (NAMRU-6), Lima and Iquitos, Peru; Instituto Nacional de Salud, Lima, Peru; Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru; Direccion Regional de Salud Loreto, Iquitos, Peru; US Naval Medical Center San Diego, San Diego, California.
authors.forename: David J
authors.initials: DJ
authors.lastname: Bacon
authors.affiliation: US Naval Medical Research Unit No. 6 (NAMRU-6), Lima and Iquitos, Peru; Instituto Nacional de Salud, Lima, Peru; Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru; Direccion Regional de Salud Loreto, Iquitos, Peru; US Naval Medical Center San Diego, San Diego, California.
authors.forename: Paul C F
authors.initials: PC
authors.lastname: Graf
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016780:Malaria, Vivax / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010568:Peru; D010966:Plasmodium vivax / Q000502:physiology; D011319:Primaquine / Q000494:pharmacology*; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D011319:Primaquine
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