title: Glucocorticoids in juvenile idiopathic arthritis.
abstract: Although the use of corticosteroids in juvenile idiopathic arthritis (JIA) is now much more limited owing to the availability of methotrexate and biological agents, there are clinical scenarios where it is still indicated. For example, corticosteroids may be indicated for intraarticular injections to prevent joint deformities, as a "bridge" drug to relieve symptoms in polyarticular disease while waiting for methotrexate and biologics to exert their full therapeutic effects, and in the treatment of chronic iridocyclitis, macrophage activation syndrome, and systemic JIA, although the advent of interleukin (IL)-1 and IL-6 blockers has greatly reduced the latter indication.
authors.affiliation: Pediatria II, Istituto Giannina Gaslini, and Department of Pediatrics, University of Genova, Genova, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Malattia
authors.forename: Alberto
authors.initials: A
authors.lastname: Martini
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000150:complications / Q000188:drug therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015863:Iridocyclitis / Q000188:drug therapy / Q000209:etiology; D008727:Methotrexate / Q000627:therapeutic use*
chemical_list: D018501:Antirheumatic Agents; D005938:Glucocorticoids; D008727:Methotrexate
keywords: chronic iridocyclitis; corticosteroids; intraarticular injections; juvenile idiopathic arthritis; macrophage activation syndrome; systemic juvenile idiopathic arthritis