title: Applications of nanoparticles for DNA based rabies vaccine.
abstract: Rabies is a fatal encephalomyelitis. Most cases occur in developing countries and are transmitted by dogs. The cell culture vaccines as associated with high cost; therefore, have not replaced the unsafe brain-derived vaccines. In the developing countries these brain-derived rabies vaccines still can be seen in action. Moreover, there will be a need for vaccines against rabies-related viruses against which classical vaccines are not always effective. The worldwide incidence of rabies and the inability of currently used vaccination strategies to provide highly potent and cost-effective therapy indicate the need for alternate control strategies. DNA vaccines have emerged as the safest vaccines and best remedy for complicated diseases like hepatitis, HIV, and rabies. A number of recombinant DNA vaccines are now being developed against several diseases such as AIDS and malaria. Therefore, it can be a valuable alternative for the production of cheaper rabies vaccines against its larger spectrum of viruses. In this review we report published data on DNA-based immunization with sequences encoding rabies with special reference to nanotechnology.
authors.forename: Muhammad Ali A
authors.initials: MA
authors.lastname: Shah
authors.forename: Sajid Umar
authors.initials: SU
authors.lastname: Khan
authors.forename: Zeeshan
authors.initials: Z
authors.lastname: Ali
authors.forename: Haowen
authors.initials: H
authors.lastname: Yang
authors.forename: Keke
authors.initials: K
authors.lastname: Liu
authors.forename: Lanlan
authors.initials: L
authors.lastname: Mao
mesh_terms: D003460:Crystallization / Q000379:methods; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods; D006801:Humans; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011818:Rabies / Q000517:prevention & control*; D011819:Rabies Vaccines; D013499:Surface Properties; D019444:Vaccines, DNA / Q000008:administration & dosage*
chemical_list: D053769:Nanocapsules; D011819:Rabies Vaccines; D019444:Vaccines, DNA