title: Strategies for the construction of tetrahydropyran rings in the synthesis of natural products.
abstract: This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products over the last seven years. While methods like cyclisation onto oxocarbenium ions, reduction of cyclic hemi-ketals, Michael reactions, hetero-Diels-Alder cycloadditions and cyclisations onto epoxides continue to find application, several other strategies including metal-mediated cyclisations, ring-closing metathesis, radical cyclisations and carbocation cyclisations have also found use. This review is intended to provide an overview of the area for those who are unfamiliar, and to refresh and remind those who do work in the area of the exciting developments in the field.
authors.affiliation: Department of Chemistry, University of York, Heslington, York, North Yorks YO10 5DD, UK. paul.clarke@york.ac.uk.
authors.forename: Nadiah Mad
authors.initials: NM
authors.lastname: Nasir
authors.forename: Kristaps
authors.initials: K
authors.lastname: Ermanis
authors.forename: Paul A
authors.initials: PA
authors.lastname: Clarke
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D061565:Cycloaddition Reaction; D007700:Kinetics; D010084:Oxidation-Reduction; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001688:Biological Products; D011714:Pyrans