title: Comparative evaluation of recombinant protein production in different biofactories: the green perspective.
abstract: In recent years, the production of recombinant pharmaceutical proteins in heterologous systems has increased significantly. Most applications involve complex proteins and glycoproteins that are difficult to produce, thus promoting the development and improvement of a wide range of production platforms. No individual system is optimal for the production of all recombinant proteins, so the diversity of platforms based on plants offers a significant advantage. Here, we discuss the production of four recombinant pharmaceutical proteins using different platforms, highlighting from these examples the unique advantages of plant-based systems over traditional fermenter-based expression platforms.
authors.affiliation: Department of Biotechnology, University of Verona, 37134 Verona, Italy.
authors.forename: Matilde
authors.identifier: 0000-0003-1978-9235
authors.initials: M
authors.lastname: Merlin
authors.affiliation: Department of Biotechnology, University of Verona, 37134 Verona, Italy.
authors.forename: Elisa
authors.identifier: 0000-0002-1133-4140
authors.initials: E
authors.lastname: Gecchele
authors.affiliation: Department of Biotechnology, University of Verona, 37134 Verona, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Capaldi
authors.affiliation: Department of Biotechnology, University of Verona, 37134 Verona, Italy.
authors.forename: Mario
authors.identifier: 0000-0002-7430-6147
authors.initials: M
authors.lastname: Pezzotti
authors.affiliation: Department of Biotechnology, University of Verona, 37134 Verona, Italy.
authors.forename: Linda
authors.identifier: 0000-0003-4007-7013
authors.initials: L
authors.lastname: Avesani
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000302:isolation & purification; D003001:Cloning, Molecular / Q000379:methods*; D055772:Green Chemistry Technology / Q000379:methods*; D030821:Plants, Genetically Modified / Q000235:genetics / Q000378:metabolism*; D015202:Protein Engineering / Q000379:methods*; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000235:genetics*
chemical_list: D001688:Biological Products; D011994:Recombinant Proteins
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