title: Commentary on the regulation of viral proteins in autophagy process.
abstract: The ability to subvert intracellular antiviral defenses is necessary for virus to survive as its replication occurs only in the host cells. Viruses have to modulate cellular processes and antiviral mechanisms to their own advantage during the entire virus life cycle. Autophagy plays important roles in cell regulation. Its function is not only to catabolize aggregate proteins and damaged organelles for recycling but also to serve as innate immunity to remove intracellular pathogenic elements such as viruses. Nevertheless, some viruses have evolved to negatively regulate autophagy by inhibiting its formation. Even more, some viruses have employed autophagy to benefit their replication. To date, there are more and more growing evidences uncovering the functions of many viral proteins to regulate autophagy through different cellular pathways. In this review, we will discuss the relationship between viruses and autophagy and summarize the current knowledge on the functions of viral proteins contributing to affect autophagy process.
authors.affiliation: Institute of Molecular Biology, National Chung Hsing University, Taichung 402, Taiwan.
authors.forename: Ching-Yuan
authors.initials: CY
authors.lastname: Cheng
authors.affiliation: Institute of Molecular Biology, National Chung Hsing University, Taichung 402, Taiwan.
authors.forename: Pei-I
authors.initials: PI
authors.lastname: Chi
authors.affiliation: Institute of Molecular Biology, National Chung Hsing University, Taichung 402, Taiwan ; Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan ; Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.
authors.forename: Hung-Jen
authors.identifier: 0000-0002-1460-1494
authors.initials: HJ
authors.lastname: Liu
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry; D001343:Autophagy; D015967:Gene Expression Regulation, Viral; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D015398:Signal Transduction; D014764:Viral Proteins / Q000737:chemistry*; D014777:Virus Diseases / Q000821:virology*
chemical_list: D000998:Antiviral Agents; D014764:Viral Proteins
references.citation: Genes Dev. 2007 Nov 15;21(22):2861-73
references.pmid: 18006683
references.citation: Curr HIV Res. 2011 Oct;9(7):505-13
references.pmid: 22103834
references.citation: J Virol. 2008 Sep;82(18):9143-53
references.pmid: 18596087
references.citation: Nat Rev Immunol. 2007 Oct;7(10):767-77
references.pmid: 17767194
references.citation: J Cell Biol. 2009 Jul 27;186(2):255-68
references.pmid: 19635843
references.citation: Oncogene. 2008 May 1;27(20):2833-42
references.pmid: 18037963
references.citation: Mol Cell Biol. 1991 Apr;11(4):1988-95
references.pmid: 1706474
references.citation: J Gen Virol. 2009 May;90(Pt 5):1093-1103
references.pmid: 19264601
references.citation: J Virol. 1996 May;70(5):2842-51
references.pmid: 8627758
references.citation: J Virol. 1998 Nov;72(11):8586-96
references.pmid: 9765397
references.citation: J Gen Virol. 2013 Dec;94(Pt 12):2664-2669
references.pmid: 24045107
references.citation: J Virol. 2006 Sep;80(18):9279-87
references.pmid: 16940539
references.citation: EMBO J. 2012 Nov 14;31(22):4304-17
references.pmid: 23064152
references.citation: Biochem Biophys Res Commun. 2005 Oct 21;336(2):709-15
references.pmid: 16143310
references.citation: J Virol. 2012 Apr;86(7):3528-40
references.pmid: 22301138
references.citation: Autophagy. 2008 Feb;4(2):254-6
references.pmid: 18196967
references.citation: Cancer Lett. 2013 May 28;332(2):141-50
references.pmid: 21071136
references.citation: J Biol Chem. 2011 Jul 15;286(28):24785-92
references.pmid: 21622569
references.citation: Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5247-51
references.pmid: 8202476
references.citation: Cell. 2008 Jan 11;132(1):27-42
references.pmid: 18191218
references.citation: Autophagy. 2008 Nov;4(8):989-97
references.pmid: 18797192
references.citation: J Virol. 2002 Mar;76(5):2029-35
references.pmid: 11836380
references.citation: J Gen Virol. 2012 Oct;93(Pt 10):2076-2097
references.pmid: 22855786
references.citation: Autophagy. 2013 May;9(5):797-8
references.pmid: 23442576
references.citation: J Cell Sci. 2009 Jun 1;122(Pt 11):1707-11
references.pmid: 19461070
references.citation: J Virol. 2013 Jan;87(2):859-71
references.pmid: 23115300
references.citation: J Virol. 2008 Mar;82(5):2241-9
references.pmid: 18077704
references.citation: J Virol. 2009 Apr;83(8):3463-74
references.pmid: 19193809
references.citation: J Virol. 2003 Oct;77(20):10917-28
references.pmid: 14512542
references.citation: J Virol. 2005 Feb;79(4):2141-50
references.pmid: 15681417
references.citation: Autophagy. 2008 Jan;4(1):101-3
references.pmid: 18000391
references.citation: Cell Death Differ. 2005 Nov;12 Suppl 2:1542-52
references.pmid: 16247502
references.citation: Virol J. 2013 Jan 28;10:36
references.pmid: 23356742
references.citation: Open Virol J. 2013 Mar 22;7:37-40
references.pmid: 23667408
references.citation: Autophagy. 2008 Jan;4(1):46-53
references.pmid: 18340111
references.citation: Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4383-8
references.pmid: 20142477
references.citation: Cell Host Microbe. 2009 Oct 22;6(4):367-80
references.pmid: 19837376
references.citation: Autophagy. 2009 Apr;5(3):321-8
references.pmid: 19066474
references.citation: Cell Host Microbe. 2012 Feb 16;11(2):167-80
references.pmid: 22341465
references.citation: Nat Rev Microbiol. 2004 Apr;2(4):301-14
references.pmid: 15031729
references.citation: Science. 2008 Feb 15;319(5865):921-6
references.pmid: 18187620
references.citation: Cells. 2013 Jan 25;2(1):83-104
references.pmid: 24709646
references.citation: J Virol. 2012 Jul;86(13):7235-40
references.pmid: 22532685
references.citation: Immunity. 2009 Apr 17;30(4):588-98
references.pmid: 19362021
references.citation: J Virol. 2006 Jun;80(12):6061-71
references.pmid: 16731945
references.citation: Blood. 2008 Feb 15;111(4):2280-9
references.pmid: 18042799
references.citation: PLoS One. 2012;7(6):e39438
references.pmid: 22745754
references.citation: J Virol. 2013 Dec;87(24):13141-9
references.pmid: 24067967
references.citation: Rev Med Virol. 2009 Nov;19(6):359-78
references.pmid: 19750559
references.citation: J Virol. 1990 Mar;64(3):1014-20
references.pmid: 2154589
references.citation: J Biol Chem. 2013 Feb 1;288(5):3571-84
references.pmid: 23233667
references.citation: EMBO Rep. 2013 Jun;14(6):534-44
references.pmid: 23619093
references.citation: Virol J. 2011 Sep 08;8:432
references.pmid: 21902836
references.citation: J Virol. 2004 Sep;78(18):10193-6
references.pmid: 15331752
references.citation: Mol Cell Biol. 1994 Apr;14(4):2361-71
references.pmid: 8139541
references.citation: Semin Cancer Biol. 2013 Oct;23(5):323-8
references.pmid: 23727156
references.citation: J Cell Sci. 2004 Sep 15;117(Pt 20):4837-48
references.pmid: 15340014
references.citation: Cell. 2005 Sep 23;122(6):927-39
references.pmid: 16179260
references.citation: Virology. 2008 May 10;374(2):240-8
references.pmid: 18353420
references.citation: Cell Host Microbe. 2007 Mar 15;1(1):23-35
references.pmid: 18005679
references.citation: J Virol. 2013 Dec;87(24):13107-14
references.pmid: 24027311
references.citation: J Virol. 2009 Feb;83(3):1168-72
references.pmid: 18787009
references.citation: AIDS. 2008 Mar 30;22(6):695-9
references.pmid: 18356598
references.citation: Nat Cell Biol. 2011 Sep 02;13(9):1016-23
references.pmid: 21892142
references.citation: J Virol. 2009 Jun;83(11):5466-76
references.pmid: 19297471
references.citation: Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):843-8
references.pmid: 9023344
references.citation: PLoS Pathog. 2011 Oct;7(10):e1002315
references.pmid: 22028656
references.citation: Int J Biochem Cell Biol. 1999 Jan;31(1):25-9
references.pmid: 10216940
references.citation: J Biol Chem. 2011 Sep 2;286(35):30780-30794
references.pmid: 21705803
references.citation: J Virol. 2010 Oct;84(20):10681-9
references.pmid: 20702639
references.citation: PLoS One. 2013 Apr 30;8(4):e62581
references.pmid: 23638118
references.citation: J Virol. 2009 Feb;83(4):1790-9
references.pmid: 19073740
references.citation: Hong Kong Med J. 2009 Feb;15 Suppl 2:37-40
references.pmid: 19258633
references.citation: J Virol. 2013 Feb;87(4):2206-14
references.pmid: 23221566
references.citation: Mol Carcinog. 2014 Sep;53(9):675-85
references.pmid: 23625539
references.citation: PLoS Pathog. 2007 Sep 7;3(9):1348-60
references.pmid: 17907806
references.citation: PLoS One. 2008 Aug 06;3(8):e2906
references.pmid: 18682838
references.citation: Mol Biol Cell. 2005 May;16(5):2544-53
references.pmid: 15743910
references.citation: J Virol. 2012 Mar;86(6):3121-34
references.pmid: 22258240
references.citation: Br J Cancer. 2012 Jan 31;106(3):429-35
references.pmid: 22240795
references.citation: PLoS Pathog. 2013 Sep;9(9):e1003609
references.pmid: 24068928
references.citation: Nat Cell Biol. 2009 Apr;11(4):385-96
references.pmid: 19270696
references.citation: J Biol Chem. 1997 May 23;272(21):13731-7
references.pmid: 9153226
references.citation: J Virol. 2009 Sep;83(17):8565-74
references.pmid: 19515765
references.citation: J Virol. 2009 Feb;83(3):1260-70
references.pmid: 19019949
references.citation: J Virol. 2012 Mar;86(5):2571-84
references.pmid: 22205736
references.citation: Virology. 2001 Nov 25;290(2):181-91
references.pmid: 11883183
references.citation: Virology. 1970 Jul;41(3):501-18
references.pmid: 5463865
references.citation: J Cell Biol. 2000 Oct 16;151(2):263-76
references.pmid: 11038174
references.citation: Curr Top Microbiol Immunol. 2009;335:1-32
references.pmid: 19802558
references.citation: J Hepatol. 2010 Apr;52(4):594-604
references.pmid: 20185200
references.citation: Nat Cell Biol. 2009 Nov;11(11):1355-62
references.pmid: 19838173