title: Protein translocation: the Sec61/SecYEG translocon caught in the act.
abstract: The Sec61/SecYEG complex mediates both the translocation of newly synthesized proteins across the membrane and the integration of transmembrane segments into the lipid bilayer. New cryo-electron microscopy studies show ribosome-channel complexes in action and reveal their repertoire of conformational states.
authors.affiliation: Biozentrum of the University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland. Electronic address: martin.spiess@unibas.ch.
authors.forename: Martin
authors.initials: M
authors.lastname: Spiess
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D004926:Escherichia coli / Q000737:chemistry*; D029968:Escherichia coli Proteins / Q000378:metabolism* / Q000648:ultrastructure*; D008565:Membrane Proteins / Q000378:metabolism* / Q000648:ultrastructure*; D063747:Methanocaldococcus / Q000737:chemistry*; D046912:Multiprotein Complexes / Q000648:ultrastructure*; D010455:Peptides / Q000378:metabolism*; D014176:Protein Biosynthesis; D021122:Protein Subunits / Q000737:chemistry*; D012270:Ribosomes / Q000000981:diagnostic imaging* / Q000378:metabolism*; D014463:Ultrasonography
chemical_list: D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D046912:Multiprotein Complexes; D010455:Peptides; D021122:Protein Subunits