title: Associations between renal impairment and anemia in older, rural Japanese men: the Nagasaki Island study.
abstract: BACKGROUND
  Renal impairment is known to be associated with atherosclerosis, which in turn is reported to be positively associated with hemoglobin levels. In addition, renal impairment is known to be associated with a form of anemia known as renal anemia.
  
  
  METHODS
  To clarify the associations between renal impairment and anemia, we conducted a cross-sectional study of 1,105 60 to 89-year-old men, who were not taking medication for anemia and were undergoing general health check-ups.
  
  
  RESULTS
  Compared with non-chronic kidney disease, chronic kidney disease (CKD) with a glomerular filtration rate (GFR) <60 mL/min/1.73 m2 was found to constitute a significant risk of anemia. However, we noted that this risk was lower for mild renal impairment (60 mL/min/1.73 m2 ≤ GFR <90 mL/min/1.73 m2). Compared with the non-CKD reference group, the classical cardiovascular risk factors adjusted odds ratio (OR) for anemia was 1.81 (1.23 to 2.68) and compared with the normal renal function (GFR ≥90 mL/min/1.73 m2) reference group, the ORs for mild renal impairment and CKD were 0.26 (0.15 to 0.47) and 0.60 (0.33 to 1.09).
  
  
  CONCLUSIONS
  Independent from classical cardiovascular risk factors, CKD, which was identified during general health check-ups, appeared to constitute a significant risk of anemia for older Japanese men. For mild renal impairment, however, this association was a reduced risk of anemia and thus possibly a higher risk of atherosclerosis.
authors.affiliation: Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan. simizicyuu@yahoo.co.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Shimpei
authors.initials: S
authors.lastname: Sato
authors.forename: Jun
authors.initials: J
authors.lastname: Koyamatsu
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Yamanashi
authors.forename: Mako
authors.initials: M
authors.lastname: Nagayoshi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kadota
authors.forename: Mami
authors.initials: M
authors.lastname: Tamai
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Arima
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kusano
authors.forename: Noboru
authors.initials: N
authors.lastname: Takamura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Maeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000150:complications* / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000453:epidemiology*; D012424:Rural Population / Q000706:statistics & numerical data*
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