title: The role of IL-6 572 C/G, 190 C/T, and 174 G/C gene polymorphisms in children's obesity.
abstract: The aim of this study was to establish the correlations between the polymorphisms of the genes interleukin (IL)-6 572, 190, and 174 in obese children. We assessed 222 hospitalized children divided into two groups: group I (control) included 110 patients with normal nutritional status, and group II consisted of 102 obesity patients. The two groups underwent IL-6 572 C/G, 190 C/T, and 174 G/C polymorphism testing, measurement of anthropometric parameters (mid-upper arm circumference and tricipital skinfold thickness), and paraclinical evaluation (protein, albumin, leptin, adiponectin, and vascular endothelial growth factor (VEGF)). We observed that phenotype CC was more frequent in obese children for IL-6 572 (p = 0.0001), whereas CG heterozygotes were more frequent in the obese group for the IL-6 190 gene (62.7 %; p = 0.0001). Leptin was dependent on IL-6 572 and IL-6 174 gene polymorphisms and albumin, whereas adiponectin was dependent on the IL-6 174 gene polymorphism. Body mass index (BMI), mid-upper arm circumference (MUAC), and tricipital skinfold thickness (TST) serum albumin levels correlated with C allele carriers of the IL-6 572 and IL-6 190 genes in children with obesity, whereas the CC genotype of IL-6 174 was a protective factor for obesity.
  
  
  CONCLUSIONS
  Obesity is most frequently associated in children with IL-6 174 C allele carriers and with IL-6 190 C allele carriers.
authors.affiliation: Pediatrics Clinic I, University of Medicine and Pharmacy , Tirgu Mureş, Romania, marginean.oana@gmail.com.
authors.forename: Mărginean Cristina
authors.initials: MC
authors.lastname: Oana
authors.forename: Bănescu
authors.initials: B
authors.lastname: Claudia
authors.forename: Duicu
authors.initials: D
authors.lastname: Carmen
authors.forename: Pitea Ana
authors.initials: PA
authors.lastname: Maria
authors.forename: Voidăzan
authors.initials: V
authors.lastname: Septimiu
authors.forename: Mărginean
authors.initials: M
authors.lastname: Claudiu
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D063766:Pediatric Obesity / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D012383:Romania
chemical_list: D005819:Genetic Markers; D015850:Interleukin-6
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