title: Are endothelial microparticles early markers of pulmonary hypertension?
abstract: OBJECTIVE
  To find out the relation between endothelial microparticles (EMPs), pulmonary arterial stiffness and thickness of pulmonary artery intima media to determine the prognosis of Eisenmenger syndrome and their correlation with echocardiographic and hemodynamic parameters.
  
  
  METHODS
  Sixteen patients with Eisenmenger syndrome and 37 control patients were included. Electron microparticles levels, angiographic and echocardiographic findings were compared.
  
  
  RESULTS
  Thickness of pulmonary arterial intima media and systolic and diastolic diameters of pulmonary artery were found significant in the patient group. CD144 and CD146 EMP values of patient group were statistically high. However, there was not any significant difference in pulmonary arterial strain, elasticity and stiffness. Positive significant relationship was found between pulmonary artery intima media thickness and CD144 in patient group. But there was not any significance between CD 146 and pulmonary artery intimamedia thickness.
  
  
  CONCLUSIONS
  Invasive methods remain as the gold standard for pulmonary hypertension diagnosis, follow-up and treatment, but it is risky and can even be fatal. Our study showed that EMPs, thickness of pulmonary artery intima media and pulmonary stiffness could be novel noninvasive modalities for the follow-up pulmonary hypertensive patients.
authors.affiliation: Division of Pediatric Cardiology, Erciyes University School of Medicine , Kayseri , Turkey.
authors.forename: Nazmi
authors.initials: N
authors.lastname: Narin
authors.forename: Ebru
authors.initials: E
authors.lastname: Yilmaz
authors.forename: Ozge
authors.initials: O
authors.lastname: Pamukcu
authors.forename: Ali
authors.initials: A
authors.lastname: Baykan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Argun
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ozyurt
authors.forename: Sertac
authors.initials: S
authors.lastname: Onan
authors.forename: Saadettin
authors.initials: S
authors.lastname: Sezer
authors.forename: Kazim
authors.initials: K
authors.lastname: Uzum
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006976:Hypertension, Pulmonary / Q000378:metabolism*; D008297:Male; D008863:Microspheres
chemical_list: D015415:Biomarkers
keywords: Children; eisenmenger syndrome; endothelial microparticles