title: A chemical approach to "rewire" neural progenitor cells.
abstract: Generation of neural progenitor cells (NPCs) from pluripotent stem cells including ESCs and iPSCs and derivation of NPCs from somatic tissues have been considered promising approaches that could be used therapeutically to restore function in patients suffering neurodegenerative diseases. A new study published in Cell Research shows, for the first time, the generation of NPCs from somatic cells by small molecule compounds under hypoxia without exogenous transcription factors.
authors.affiliation: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
authors.forename: Min-Zu
authors.initials: MZ
authors.lastname: Wu
authors.affiliation: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
authors.forename: Mo
authors.initials: M
authors.lastname: Li
authors.affiliation: 1] National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [2] Beijing Institute for Brain Disorders, Beijing 100875, China.
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Liu
authors.affiliation: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Izpisua Belmonte
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D058953:Neural Stem Cells / Q000187:drug effects*; D011720:Pyrazoles / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology*
chemical_list: C473711:Chir 99021; D004791:Enzyme Inhibitors; D011720:Pyrazoles; D011725:Pyridines; D011743:Pyrimidines; C550621:RepSox; D014635:Valproic Acid
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