title: Design and synthesis of new vancomycin derivatives.
abstract: A set of vancomycin derivatives with lipid chain attached via a glyceric acid linker was designed and synthesized. A concise synthesis towards these derivatives was developed and the IC50s of these new lipoglycopeptides were tested. Some of them showed very potent activity against both vancomycin sensitive and resistant strains.
authors.affiliation: College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Gu
authors.affiliation: College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Chen
authors.affiliation: College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China; Acesys PharmaTech, Inc., Science and Technology Building 24B, 5 Xing Mo Fang Road, Nanjing 210009, China. Electronic address: minge88@gmail.com.
authors.forename: Min
authors.initials: M
authors.lastname: Ge
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin
keywords: Anti-bacterial; Synthesis; Vancomycin