title: Diagnosis, prognosis and therapeutic role of circulating miRNAs in cardiovascular diseases.
abstract: Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although much progress has been made for cardiovascular diseases in diagnosis, treatment and prognosis during the past two decades, the clinical need for a novel diagnostic biomarker and new therapeutic interventions to decrease the cardiovascular disease incidence is ongoing. MicroRNAs (miRNAs) are endogenous, small (∼22 nucleotides), single-stranded, non-coding RNAs that regulate gene expression and are detectable in whole blood, serum, plasma, urine and other body fluids in a highly stable form. Accumulating evidence suggests that miRNAs are potential novel biomarkers with high sensitivity for early diagnosis and modern treatment for cardiovascular diseases. Altered circulating miRNAs expressions have been reported in acute myocardial infarction (AMI), acute coronary syndrome (ACS), stable coronary artery disease, heart failure, atherosclerosis, essential hypertension and stroke. In the present review, we examine more recent data regarding circulating miRNAs and their potential roles in diagnosis, prognosis and therapeutic strategies for cardiovascular diseases. In addition, we briefly present our own recent experience in detecting circulating miRNAs, and the significance of these miRNAs in AMI prognosis.
authors.affiliation: Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410078, China.
authors.forename: Ali Sheikh Md
authors.initials: AS
authors.lastname: Sayed
authors.affiliation: Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410078, China; Center for Vascular Biology and Inflammation, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, U.S.A.
authors.forename: Ke
authors.initials: K
authors.lastname: Xia
authors.affiliation: Department of Obstetrics and Gynecology, Xiangya 3(rd) Hospital, Central South University, Changsha 410013, China.
authors.forename: Umme
authors.initials: U
authors.lastname: Salma
authors.affiliation: Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410078, China. Electronic address: tianluny@163.com.
authors.forename: Tianlun
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China. Electronic address: Junpeng@csu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Peng
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D035683:MicroRNAs / Q000097:blood*; D011379:Prognosis
chemical_list: D035683:MicroRNAs
keywords: Biomarkers; Cardiovascular disease (CVD); Circulating miRNAs; Prognosis; Treatment