title: Executive control processes underlying multi-item working memory.
abstract: A dominant view of prefrontal cortex (PFC) function is that it stores task-relevant information in working memory. To examine this and determine how it applies when multiple pieces of information must be stored, we trained two subjects to perform a multi-item color change detection task and recorded activity of neurons in PFC. Few neurons encoded the color of the items. Instead, the predominant encoding was spatial: a static signal reflecting the item's position and a dynamic signal reflecting the subject's covert attention. These findings challenge the notion that PFC stores task-relevant information. Instead, we suggest that the contribution of PFC is in controlling the allocation of resources to support working memory. In support of this, we found that increased power in the alpha and theta bands of PFC local field potentials, which are thought to reflect long-range communication with other brain areas, was correlated with more precise color representations.
authors.affiliation: 1] Department of Neuroscience, Columbia University, New York, New York, USA. [2] Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, California, USA.
authors.forename: Antonio H
authors.initials: AH
authors.lastname: Lara
authors.affiliation: 1] Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, California, USA. [2] Department of Psychology, University of California at Berkeley, Berkeley, California, USA.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Wallis
mesh_terms: D000818:Animals; D001288:Attention / Q000502:physiology*; D003118:Color Perception / Q000502:physiology*; D056344:Executive Function / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*
references.citation: J Neurosci. 2013 Apr 10;33(15):6516-23
references.pmid: 23575849
references.citation: Cereb Cortex. 2010 Jan;20(1):141-68
references.pmid: 19406905
references.citation: Nature. 2008 Sep 11;455(7210):227-31
references.pmid: 18690210
references.citation: Nat Neurosci. 2012 Jan 29;15(3):456-62, S1-2
references.pmid: 22286175
references.citation: Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19585-90
references.pmid: 24218604
references.citation: Nature. 1999 Jun 3;399(6735):470-3
references.pmid: 10365959
references.citation: Trends Cogn Sci. 2003 Dec;7(12):547-52
references.pmid: 14643371
references.citation: Nat Neurosci. 2013 Aug;16(8):997-9
references.pmid: 23817547
references.citation: J Exp Psychol Gen. 1999 Sep;128(3):309-331
references.pmid: 10513398
references.citation: Nat Neurosci. 2008 Aug;11(8):877-9
references.pmid: 18622399
references.citation: Science. 2008 Aug 8;321(5890):851-4
references.pmid: 18687968
references.citation: Nat Neurosci. 2001 Mar;4(3):311-6
references.pmid: 11224549
references.citation: Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11252-5
references.pmid: 21690375
references.citation: Neuron. 2010 Jun 10;66(5):796-807
references.pmid: 20547135
references.citation: J Neurophysiol. 2000 Jul;84(1):451-9
references.pmid: 10899218
references.citation: J Neurosci. 2012 Sep 19;32(38):12983-9
references.pmid: 22993415
references.citation: J Cogn Neurosci. 2013 May;25(5):754-61
references.pmid: 23469889
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3228-33
references.pmid: 20133762
references.citation: Neuroimage. 2006 Jan 15;29(2):567-77
references.pmid: 16289928
references.citation: Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7580-5
references.pmid: 20368447
references.citation: Nature. 1997 Nov 20;390(6657):279-81
references.pmid: 9384378
references.citation: Cereb Cortex. 2007 Feb;17(2):284-93
references.pmid: 16514108
references.citation: Neuron. 2010 Apr 29;66(2):300-14
references.pmid: 20435005
references.citation: J Neurosci. 2010 Jan 6;30(1):350-60
references.pmid: 20053916
references.citation: Behav Brain Sci. 2001 Feb;24(1):87-114; discussion 114-85
references.pmid: 11515286
references.citation: Nature. 2004 Apr 15;428(6984):751-4
references.pmid: 15085133
references.citation: Psychon Bull Rev. 1994 Jun;1(2):202-38
references.pmid: 24203471
references.citation: Cereb Cortex. 2014 Feb;24(2):532-40
references.pmid: 23131804
references.citation: J Vis. 2004 Dec 29;4(12):1120-35
references.pmid: 15669916
references.citation: Neuron. 2013 Apr 24;78(2):364-75
references.pmid: 23562541
references.citation: Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4651-6
references.pmid: 22392988
references.citation: Nature. 2008 May 8;453(7192):233-5
references.pmid: 18385672
references.citation: Int J Psychophysiol. 2000 Dec 1;38(3):301-13
references.pmid: 11102669
references.citation: Nature. 1993 Oct 21;365(6448):753-6
references.pmid: 8413653
references.citation: Nature. 2013 May 30;497(7451):585-90
references.pmid: 23685452
references.citation: J Neurosci. 2012 Nov 28;32(48):17382-90
references.pmid: 23197729
references.citation: Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21341-6
references.pmid: 19926847
references.citation: Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):5975-9
references.pmid: 18420818
references.citation: Science. 1997 May 2;276(5313):821-4
references.pmid: 9115211
references.citation: Int J Psychophysiol. 2005 Aug;57(2):97-103
references.pmid: 15967528
references.citation: Nature. 2004 Apr 15;428(6984):748-51
references.pmid: 15085132
references.citation: J Neurophysiol. 2007 May;97(5):3494-507
references.pmid: 17360822
references.citation: Cogn Psychol. 1980 Jan;12(1):97-136
references.pmid: 7351125
references.citation: Neuron. 2013 Dec 4;80(5):1277-89
references.pmid: 24239123
references.citation: Front Psychol. 2011 Jun 10;2:128
references.pmid: 21713012
references.citation: J Neurosci. 2009 Jan 21;29(3):765-74
references.pmid: 19158302
references.citation: Science. 2006 Sep 15;313(5793):1626-8
references.pmid: 16973878
references.citation: Vision Res. 2000;40(10-12):1489-506
references.pmid: 10788654
references.citation: J Vis. 2012 Mar 14;12(3):
references.pmid: 22419756
references.citation: Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):18034-9
references.pmid: 19805195
references.citation: Front Comput Neurosci. 2010 Oct 06;4:126
references.pmid: 21031029
references.citation: Nature. 2005 Nov 24;438(7067):500-3
references.pmid: 16306992