title: Optic neuritis in Hong Kong: a 1-year follow-up study.
abstract: To investigate the etiology and prevalence of optic neuritis in a Chinese population. This was a single centre prospective cohort study. Consecutive patients with either a first or recurrent attack of optic neuritis from November 2010 to December 2011 were recruited from a district hospital in Hong Kong Special Administrative Region, China. All patients underwent serology testing for NMO (neuromyelitis optica) IgG; oligoclonal bands from lumbar puncture; computer tomography and contrast magnetic resonance imaging (MRI) of the brain and orbit as well as visual field; and optical coherence tomography testing. Patients were followed up for 1 year after the initial attack. 30 optic neuritis subjects were recruited. 73.3 % (22/30) remain as clinical isolated syndrome (CIS) after 1-year follow-up. 10 % (3/30) patients developed multiple sclerosis. 10 % (3/30) were diagnosed with NMO and 6.7 % (2/30) with NMO-spectrum disorder. The majority of acute unilateral optic neuritis in Chinese was CIS in origin although a fraction does progress to develop MS or NMO-related disorders. Clinicians should be aware of the associations and offer appropriate systemic workups.
authors.affiliation: Department of Medicine and Geriatric, Caritas Medical Centre, Hong Kong, Special Administrative Region China.
authors.forename: Patrick P K
authors.initials: PP
authors.lastname: Lau
authors.forename: Gordon S K
authors.initials: GS
authors.lastname: Yau
authors.forename: Jacky W Y
authors.initials: JW
authors.lastname: Lee
authors.forename: Winnie W Y
authors.initials: WW
authors.lastname: Wong
authors.forename: Victor T Y
authors.initials: VT
authors.lastname: Tam
authors.forename: Eric Y T
authors.initials: EY
authors.lastname: Chan
authors.forename: Doris M W
authors.initials: DM
authors.lastname: Tse
authors.forename: Can Y F
authors.initials: CY
authors.lastname: Yuen
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications; D009471:Neuromyelitis Optica / Q000150:complications; D009902:Optic Neuritis / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D011446:Prospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods
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