title: Strategies in the design of small-molecule fluorescent probes for peptidases.
abstract: Peptidases, which can cleave specific peptide bonds in innumerable categories of substrates, usually present pivotal positions in protein activation, cell signaling and regulation as well as in the origination of amino acids for protein generation or application in other metabolic pathways. They are also involved in many pathological conditions, such as cancer, atherosclerosis, arthritis, and neurodegenerative disorders. This review article aims to conduct a wide-ranging survey on the development of small-molecule fluorescent probes for peptidases, as well as to realize the state of the art in the tailor-made probes for diverse types of peptidases.
authors.affiliation: Key Laboratory of Chemical Biology (MOE), Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, China.
authors.forename: Laizhong
authors.initials: L
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Lupei
authors.initials: L
authors.lastname: Du
authors.forename: Minyong
authors.initials: M
authors.lastname: Li
mesh_terms: D015195:Drug Design; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D015335:Molecular Probes / Q000737:chemistry* / Q000494:pharmacology*; D010447:Peptide Hydrolases / Q000187:drug effects* / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D015398:Signal Transduction
chemical_list: D005456:Fluorescent Dyes; D015335:Molecular Probes; D010447:Peptide Hydrolases
keywords: design strategies; peptidases; small-molecule fluorescent probes