title: Comparing axonal excitability in past polio to amyotrophic lateral sclerosis.
abstract: BACKGROUND
  Poliomyelitis causes selective destruction of anterior horn cells and usually has a stable disease course post-infection. We assessed the excitability characteristics in patients with a stable course after past poliomyelitis and compared them with changes described in amyotrophic lateral sclerosis (ALS).
  
  
  METHODS
  The excitability characteristics of motor and sensory nerves were studied in 10 subjects with stable past poliomyelitis.
  
  
  RESULTS
  Motor rheobase was increased, but there were no significant changes in strength-duration properties or depolarizing threshold electrotonus, as have been seen in previous studies of ALS.
  
  
  CONCLUSIONS
  There is minimal change in axonal excitability properties in patients with stable past poliomyelitis. The results may signify sufficient compensation in the stable state of the disease. Increased subexcitability in 1 subject with demonstrable hyperexcitability may represent compensation for increased ectopic activity rather than a different process in surviving motor neurons. Muscle Nerve 50: 602-604, 2014.
authors.affiliation: Department of Neurology and Clinical Neurophysiology, Royal North Shore Hospital, Sydney, St Leonards, New South Wales, 2065, Australia.
authors.forename: Christina
authors.initials: C
authors.lastname: Liang
authors.forename: Karl
authors.initials: K
authors.lastname: Ng
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology* / Q000473:pathology*; D001369:Axons / Q000502:physiology*; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D011051:Poliomyelitis / Q000150:complications*
keywords: amyotrophic lateral sclerosis; motor neuron disorders; nerve excitability; past polio; poliomyelitis