title: Bronchiolitis in a patient with ulcerative colitis treated with erythromycin.
abstract: A 47-year-old man was referred to our hospital with an abnormal shadow on a chest X-ray. He had a history of untreated chronic sinusitis and suspected ulcerative colitis (UC). Chest CT revealed a diffuse centrilobular granular shadow, while laboratory tests demonstrated an increased proportion of neutrophils; however, no microorganisms were detected in bronchoalveolar lavage fluid. Therefore, sinobronchial syndrome or small airway disease associated with UC was diagnosed, and the patient was treated with long-term erythromycin therapy. Small airway disease associated with UC is usually treated with steroids. Our experience shows that airway involvement in patients with inflammatory bowel disease can be treated with macrolides.
authors.affiliation: The Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
authors.forename: Noriho
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ishimatsu
authors.forename: Hanako
authors.initials: H
authors.lastname: Koyama
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kakugawa
authors.forename: Shintaro
authors.initials: S
authors.lastname: Hara
authors.forename: Masaomi
authors.initials: M
authors.lastname: Tomonaga
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Harada
authors.forename: Shota
authors.initials: S
authors.lastname: Nakashima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001988:Bronchiolitis / Q000188:drug therapy* / Q000453:epidemiology*; D001992:Bronchoalveolar Lavage Fluid; D003093:Colitis, Ulcerative / Q000453:epidemiology*; D004917:Erythromycin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic; D012852:Sinusitis / Q000188:drug therapy* / Q000453:epidemiology*; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin