title: Thrombosis, platelets, microparticles and PAH: more than a clot.
abstract: Pulmonary arterial hypertension (PAH) is a progressive disease that involves pathological remodeling, vasoconstriction and thrombosis. Alterations in hemostasis, coagulation and platelet activation are consistently observed in PAH patients. Microparticles derived from platelets, inflammatory cells and the endothelium are an increasingly well-recognized signal in a variety of cardiovascular diseases, including PAH. This review will focus on the roles of coagulation, thrombosis, platelet activation and microparticles in the pathology and progression of PAH.
authors.affiliation: Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA.
authors.forename: Katie L
authors.initials: KL
authors.lastname: Lannan
authors.affiliation: Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Pathology and Laboratory Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Phipps
authors.affiliation: Aab Cardiovascular Research Institute and Division of Pulmonary and Critical Care Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA. Electronic address: Jim_White@urmc.rochester.edu.
authors.forename: R James
authors.initials: RJ
authors.lastname: White
mesh_terms: D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000473:pathology*; D055252:Cell-Derived Microparticles / Q000473:pathology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000473:pathology*; D015539:Platelet Activation / Q000502:physiology; D013927:Thrombosis / Q000473:pathology*
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