title: Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na 3 AlF 6 , as an Efficient Catalyst.
abstract: Considerable attention has been focused on the synthesis of benzimidazoles due to having a broad spectrum of biological activities such as anti-parasitic, fungicidal, anti-thelemintic and anti-inflammatory activities. As a part of our research work in this area, a series of benzimidasole derivatives (3a-n) were synthesized in good to high yields by reaction of o-phenylenediamine and different aromatic aldehydes in the presence of sodium hexafluroaluminate, Na3AlF6, as an efficient catalyst at 50 (◦)C. This environmentally benign and practical method offers several advantages, such as high yields, use of available catalyst, mild reaction conditions and easy workup. The antibacterial activity of these benzimidasoles was also evaluated using Staphylococcus aureus (mm) and Escherichia coli (mm) bacterial strain. All synthesized materials were characterized using IR and NMR spectroscopy as well as microanalyses data.
authors.affiliation: Department of Chemistry, Faculty of Science, Arak University, Arak 38156-8-8349, Iran.
authors.forename: Akbar
authors.initials: A
authors.lastname: Mobinikhaledi
authors.affiliation: Department of Biology, Faculty of Science, Arak University, Arak 38156-8-8349, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Hamta
authors.affiliation: Department of Chemistry, Faculty of Science, Payam Noor University.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Kalhor
authors.affiliation: Department of Biochemistry, Shiraz University, Shiraz, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Shariatzadeh
keywords: Aromatic aldehydes; Bbenzimidaazole; Catalyst; o-Phenylenediamine
references.citation: Iran J Pharm Res. 2013 Summer;12(3):255-65
references.pmid: 24250631
references.citation: Iran J Pharm Res. 2013 Summer;12(3):281-7
references.pmid: 24250634
references.citation: Chem Rev. 2003 Mar;103(3):893-930
references.pmid: 12630855
references.citation: J Med Chem. 1996 Feb 16;39(4):992-8
references.pmid: 8632422
references.citation: J Med Chem. 1998 Apr 9;41(8):1252-62
references.pmid: 9548815