title: A new component of the Fraser complex.
abstract: In embryos, the Fraser complex (FC) mediates epithelial-connective tissue interactions. Loss of expression of FC components leads to Fraser syndrome (FS), in which cohesion of epithelial tissues and stroma is perturbed. Using zebrafish, Richardson et al. (this issue) identified the protein AMACO in the FC. We discuss the utility of zebrafish in determining FC functions and identifying FS targets.
authors.affiliation: School of Molecular Biosciences, Washington State University, Pullman, Washington, USA.
authors.forename: Sho
authors.initials: S
authors.lastname: Hiroyasu
authors.affiliation: School of Molecular Biosciences, Washington State University, Pullman, Washington, USA. Electronic address: jcr.jones@vetmed.wsu.edu.
authors.forename: Jonathan C R
authors.initials: JCR
authors.lastname: Jones
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000378:metabolism*; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D058497:Fraser Syndrome / Q000378:metabolism*; D008297:Male; D029961:Zebrafish Proteins / Q000235:genetics* / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; C549398:VWA2 protein, zebrafish; C480232:Vwa2 protein, mouse; D029961:Zebrafish Proteins
references.citation: Dermatol Clin. 2010 Jan;28(1):171-8
references.pmid: 19945632
references.citation: J Biol Chem. 2003 Dec 12;278(50):50240-9
references.pmid: 14506275
references.citation: J Cell Biol. 2012 May 28;197(5):677-89
references.pmid: 22613833
references.citation: Cold Spring Harb Perspect Biol. 2011 Feb 01;3(2):
references.pmid: 21421915
references.citation: Int J Biochem Cell Biol. 2011 Apr;43(4):487-95
references.pmid: 21182980
references.citation: Matrix Biol. 2009 Oct;28(8):456-62
references.pmid: 19651211
references.citation: J Med Genet. 2012 May;49(5):303-6
references.pmid: 22510445
references.citation: PLoS Genet. 2010 Apr 15;6(4):e1000907
references.pmid: 20419147
references.citation: Dis Model Mech. 2013 Nov;6(6):1426-33
references.pmid: 24046351
references.citation: J Invest Dermatol. 2014 May;134(5):1313-1322
references.pmid: 24232570