title: Identification of new synthetic PDE-5 inhibitors analogues found as minor components in a dietary supplement.
abstract: A dietary supplement sold in erotic shops was analysed. It contains dithiodesmethylcarbodenafil as the major component, which was already reported as an adulterant in dietary supplements. Additionally three more compounds were found and their structures were elucidated after isolation using NMR and mass spectroscopy. They were designated as isonitrosoprodenafil, dithiodesethylcarbodenafil and norcarbodenafil.
authors.affiliation: Bavarian Health and Food Safety Authority, Veterinärstr. 2, 85764 Oberschleißheim, Germany. Electronic address: nicholas.schramek@lgl.bayern.de.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Schramek
authors.affiliation: Bavarian Health and Food Safety Authority, Veterinärstr. 2, 85764 Oberschleißheim, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Wollein
authors.affiliation: Lehrstuhl für Biochemie, Technische Universität München, Lichtenbergstr. 4, 85435 Garching, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Eisenreich
mesh_terms: D019587:Dietary Supplements / Q000032:analysis* / Q000592:standards; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D058986:Phosphodiesterase 5 Inhibitors / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D010879:Piperazines / Q000032:analysis / Q000302:isolation & purification; D011720:Pyrazoles / Q000032:analysis / Q000302:isolation & purification; D011743:Pyrimidines / Q000032:analysis / Q000302:isolation & purification
chemical_list: D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011720:Pyrazoles; D011743:Pyrimidines
keywords: Adulterants; Dietary supplement; Dithiodesethylcarbodenafil; Dithiodesmethylcarbodenafil; Isonitrosoprodenafil; Nitrosoprodenafil; Norcarbodenafil; Sildenafil analogues