title: Cell transfer therapy for cancer: past, present, and future.
abstract: Cell transfer therapy for cancer has made a rapid progress recently and the immunotherapy has been recognized as the fourth anticancer modality after operation, chemotherapy, and radiotherapy. Lymphocytes used for cell transfer therapy include dendritic cells, natural killer (NK) cells, and T lymphocytes such as tumor-infiltrating lymphocytes (TILs) and cytotoxic T lymphocytes (CTLs). In vitro activated or engineered immune cells can traffic to cancer tissues to elicit persistent antitumor immune response which is very important especially after immunosuppressive treatments such as chemotherapy. In this review, we overviewed recent advances in the exploration of dendritic cells, NK cells, and T cells for the treatment of human cancer cells.
authors.affiliation: Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Qian
authors.affiliation: Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Hongchuan
authors.initials: H
authors.lastname: Jin
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D016219:Immunotherapy, Adoptive; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism
references.citation: Nat Immunol. 2008 May;9(5):486-94
references.pmid: 18425105
references.citation: PLoS One. 2013;8(3):e57922
references.pmid: 23483943
references.citation: Immunol Lett. 2009 Jan 29;122(1):30-6
references.pmid: 19046991
references.citation: Nat Rev Immunol. 2011 Sep 23;11(10):658-71
references.pmid: 21941294
references.citation: Clin Cancer Res. 2012 Apr 15;18(8):2199-209
references.pmid: 22407828
references.citation: Hum Gene Ther. 2002 Nov 1;13(16):1971-80
references.pmid: 12427307
references.citation: Cancer Res. 2012 Apr 1;72(7):1683-93
references.pmid: 22307839
references.citation: J Exp Med. 2005 Oct 3;202(7):907-12
references.pmid: 16203864
references.citation: PLoS One. 2012;7(12):e52926
references.pmid: 23300824
references.citation: Blood. 1993 May 15;81(10):2658-63
references.pmid: 8490175
references.citation: J Clin Immunol. 1982 Oct;2(4):249-63
references.pmid: 6292259
references.citation: Cancer. 2009 Aug 15;115(16):3670-9
references.pmid: 19536890
references.citation: J Clin Oncol. 2006 Jul 1;24(19):3089-94
references.pmid: 16809734
references.citation: Exp Hematol. 2001 Oct;29(10):1157-68
references.pmid: 11602317
references.citation: N Engl J Med. 1988 Dec 22;319(25):1676-80
references.pmid: 3264384
references.citation: Cancer Immunol Immunother. 2007 Dec;56(12):1911-20
references.pmid: 17487487
references.citation: Mol Ther. 2013 Nov;21(11):2122-9
references.pmid: 23831595
references.citation: J Mol Med (Berl). 2009 Feb;87(2):199-210
references.pmid: 19002424
references.citation: Nat Rev Cancer. 2012 Mar 22;12(4):265-77
references.pmid: 22437871
references.citation: Scand J Immunol. 2010 Feb;71(2):70-82
references.pmid: 20384858
references.citation: Nat Med. 2008 Nov;14(11):1264-70
references.pmid: 18978797
references.citation: Mol Ther. 2009 Aug;17(8):1453-64
references.pmid: 19384291
references.citation: J Clin Oncol. 2011 Mar 1;29(7):917-24
references.pmid: 21282551
references.citation: Clin Cancer Res. 2008 Dec 15;14(24):8112-22
references.pmid: 19088026
references.citation: Immunol Today. 1990 Jul;11(7):237-44
references.pmid: 2201309
references.citation: J Transl Med. 2013 Mar 28;11:83
references.pmid: 23536996
references.citation: Mol Ther. 2010 Feb;18(2):413-20
references.pmid: 19773745
references.citation: Mol Ther. 2011 Mar;19(3):620-6
references.pmid: 21157437
references.citation: Sci Transl Med. 2011 Aug 10;3(95):95ra73
references.pmid: 21832238
references.citation: N Engl J Med. 2011 Jun 2;364(22):2119-27
references.pmid: 21631324
references.citation: Surg Oncol Clin N Am. 2013 Oct;22(4):765-83
references.pmid: 24012398
references.citation: Blood. 2009 Jan 29;113(5):1006-15
references.pmid: 18978209
references.citation: J Immunother. 2008 Jan;31(1):63-71
references.pmid: 18157013
references.citation: J Immunol. 2007 Jan 1;178(1):5-25
references.pmid: 17182535
references.citation: Immunotherapy. 2012 Jan;4(1):1-4
references.pmid: 22149992
references.citation: Blood. 1988 Jan;71(1):13-29
references.pmid: 3257143
references.citation: Cancer Immun. 2013 May 01;13:8
references.pmid: 23833565
references.citation: J Hematother Stem Cell Res. 2001 Aug;10(4):535-44
references.pmid: 11522236
references.citation: Blood. 2005 Jun 15;105(12):4677-84
references.pmid: 15713795
references.citation: J Immunol. 2007 Nov 1;179(9):5845-54
references.pmid: 17947658
references.citation: Hematol Oncol. 2009 Sep;27(3):130-9
references.pmid: 19294626
references.citation: J Immunol. 2003 Sep 15;171(6):3287-95
references.pmid: 12960359
references.citation: Blood. 2012 Jan 19;119(3):696-706
references.pmid: 22117050
references.citation: Oncoimmunology. 2013 Apr 1;2(4):e23811
references.pmid: 23734329
references.citation: Cancer Res. 2000 Jun 15;60(12):3254-61
references.pmid: 10866319
references.citation: Exp Hematol. 2007 Sep;35(9):1388-97
references.pmid: 17656004
references.citation: Mol Ther. 2010 Apr;18(4):843-51
references.pmid: 20179677
references.citation: J Immunother. 2003 Jul-Aug;26(4):332-42
references.pmid: 12843795
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3360-5
references.pmid: 19211796
references.citation: Anticancer Res. 2006 May-Jun;26(3B):2237-42
references.pmid: 16821594
references.citation: Gene Ther. 2007 Jun;14(11):863-71
references.pmid: 17344900
references.citation: Cancer Immunol Immunother. 2008 Oct;57(10):1541-52
references.pmid: 18317755
references.citation: Blood. 2009 Jul 16;114(3):535-46
references.pmid: 19451549
references.citation: Br J Cancer. 1999 Nov;81(6):1009-16
references.pmid: 10576658
references.citation: Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11895-9
references.pmid: 20547850
references.citation: Cancer Res. 2009 Dec 1;69(23):9003-11
references.pmid: 19903853
references.citation: J Autoimmun. 2009 Nov-Dec;33(3-4):275-81
references.pmid: 19682859
references.citation: J Immunother. 2005 May-Jun;28(3):175-82
references.pmid: 15838373
references.citation: Science. 2002 Mar 15;295(5562):2097-100
references.pmid: 11896281
references.citation: Clin Cancer Res. 2011 Aug 15;17(16):5343-52
references.pmid: 21737507
references.citation: J Exp Med. 1982 Jun 1;155(6):1823-41
references.pmid: 6176669
references.citation: Clin Cancer Res. 2003 Feb;9(2):606-12
references.pmid: 12576425
references.citation: Nat Rev Immunol. 2001 Oct;1(1):41-9
references.pmid: 11905813
references.citation: Cytokine. 2008 Apr;42(1):128-36
references.pmid: 18280748
references.citation: Mol Immunol. 2012 Jul;51(3-4):263-72
references.pmid: 22503210
references.citation: Cytotherapy. 2005;7(1):16-22
references.pmid: 16040380
references.citation: J Immunol. 2004 Jan 1;172(1):104-13
references.pmid: 14688315
references.citation: Mol Immunol. 2008 Mar;45(5):1276-87
references.pmid: 17950877
references.citation: Blood. 2012 Jun 14;119(24):5678-87
references.pmid: 22538857
references.citation: Cancer Immunol Immunother. 2010 Dec;59(12):1781-9
references.pmid: 20703455
references.citation: Clin Cancer Res. 2011 Oct 1;17(19):6287-97
references.pmid: 21844012
references.citation: Nat Rev Immunol. 2007 May;7(5):329-39
references.pmid: 17438573
references.citation: J Immunol. 2008 May 1;180(9):6392-401
references.pmid: 18424763
references.citation: Mol Cancer Ther. 2011 Mar;10(3):540-9
references.pmid: 21209070
references.citation: Science. 1999 Jul 30;285(5428):727-9
references.pmid: 10426993
references.citation: Cancer. 1995 Sep 1;76(5):824-32
references.pmid: 8625186
references.citation: Hum Gene Ther. 2002 Mar 1;13(4):569-75
references.pmid: 11874634
references.citation: Cancer. 1986 Dec 15;58(12):2764-72
references.pmid: 3490903
references.citation: Clin Orthop Relat Res. 1991 Jan;(262):3-11
references.pmid: 1984929
references.citation: Nat Rev Cancer. 2013 Aug;13(8):525-41
references.pmid: 23880905
references.citation: Blood. 2005 Jul 1;106(1):376-83
references.pmid: 15755898
references.citation: Mol Ther. 2010 Mar;18(3):651-9
references.pmid: 19935776
references.citation: Mol Ther. 2005 Nov;12(5):933-41
references.pmid: 15979412
references.citation: Nat Med. 2011 Sep 18;17(10):1290-7
references.pmid: 21926977
references.citation: Blood. 2012 Mar 22;119(12):2709-20
references.pmid: 22160384
references.citation: Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1969-74
references.pmid: 14762166
references.citation: Blood. 2007 Apr 15;109(8):3603-6
references.pmid: 17179231
references.citation: Immunotherapy. 2012 Nov;4(11):1103-5
references.pmid: 23194360
references.citation: Clin Cancer Res. 2011 Jul 1;17(13):4550-7
references.pmid: 21498393
references.citation: Blood. 2011 May 5;117(18):4816-25
references.pmid: 21300979
references.citation: Cancer J. 2010 Jul-Aug;16(4):342-7
references.pmid: 20693845
references.citation: J Clin Immunol. 2009 Nov;29(6):806-14
references.pmid: 19517218
references.citation: Anticancer Res. 2008 Nov-Dec;28(6B):3997-4002
references.pmid: 19192663
references.citation: N Engl J Med. 2011 Jun 30;364(26):2517-26
references.pmid: 21639810
references.citation: J Clin Invest. 2011 May;121(5):1822-6
references.pmid: 21540550
references.citation: Blood. 2005 Apr 15;105(8):3051-7
references.pmid: 15632206
references.citation: Cancer Res. 2005 Mar 1;65(5):2001-8
references.pmid: 15753400
references.citation: N Engl J Med. 2010 Jul 29;363(5):411-22
references.pmid: 20818862
references.citation: Int J Cancer. 2013 Feb 15;132(4):967-77
references.pmid: 22870862
references.citation: Blood. 2011 Sep 22;118(12):3273-9
references.pmid: 21791425
references.citation: Science. 2006 Oct 6;314(5796):126-9
references.pmid: 16946036
references.citation: Blood. 2013 Aug 8;122(6):863-71
references.pmid: 23770775
references.citation: Blood. 2010 Nov 18;116(20):4099-102
references.pmid: 20668228
references.citation: Cell Mol Immunol. 2013 May;10(3):230-52
references.pmid: 23604045
references.citation: Exp Hematol. 2005 Oct;33(10):1160-71
references.pmid: 16219538
references.citation: J Immunother. 2009 Jul-Aug;32(6):602-12
references.pmid: 19483649
references.citation: Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):E1408-16
references.pmid: 22123951
references.citation: Semin Immunol. 2008 Oct;20(5):301-7
references.pmid: 18395462
references.citation: Cancer. 2006 Aug 1;107(3):640-8
references.pmid: 16804934
references.citation: Gene Ther. 2002 Apr;9(8):527-35
references.pmid: 11948378
references.citation: Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6106-15
references.pmid: 17062687
references.citation: Nat Med. 2012 May;18(5):807-815
references.pmid: 22466705
references.citation: Blood. 2011 Jan 6;117(1):72-82
references.pmid: 20889925
references.citation: Cancer Chemother Biol Response Modif. 2002;20:315-41
references.pmid: 12703212
references.citation: J Natl Cancer Inst. 1996 Jan 17;88(2):100-8
references.pmid: 8537970
references.citation: N Engl J Med. 2013 Apr 18;368(16):1509-1518
references.pmid: 23527958
references.citation: J Biol Response Mod. 1984 Oct;3(5):501-11
references.pmid: 6389777
references.citation: Cancer Res. 2009 May 15;69(10):4309-18
references.pmid: 19435909
references.citation: Proc R Soc Med. 1910;3(Surg Sect):1-48
references.pmid: 19974799
references.citation: Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5426-35
references.pmid: 17855649
references.citation: J Exp Med. 2004 Jun 7;199(11):1503-11
references.pmid: 15173207
references.citation: Expert Rev Anticancer Ther. 2006 Sep;6(9):1163-7
references.pmid: 17020451