title: Role of the D1 receptor for the dopamine agonist-induced one-trial behavioral sensitization of preweanling rats.
abstract: BACKGROUND
  The neural mechanisms mediating the ontogeny of behavioral sensitization are poorly understood.
  
  
  OBJECTIVE
  The purpose of the present study was to determine the role of the D1 receptor for the induction of dopamine agonist-induced behavioral sensitization during the preweanling period.
  
  
  METHODS
  In the first experiment, the early ontogeny of R-propylnorapomorphine (NPA)-induced behavioral sensitization was examined by pretreating male and female rats with saline or NPA (0.5, 1, or 2 mg/kg, intraperitoneally (IP)) before placement in activity chambers on postnatal day (PD) 12, 16, 20, or 24. One day later, rats were tested with lower doses of NPA and the occurrence of locomotor sensitization was determined. In subsequent experiments, rats were injected with saline or the D1 receptor antagonist SCH23390 (0.1, 0.5, 1, or 5 mg/kg, IP) 0, 15, 30, or 60 min before cocaine, methamphetamine (METH), or NPA pretreatment. The next day, rats were tested with the same dopamine agonist again and sensitized responding was assessed.
  
  
  RESULTS
  NPA produced one-trial behavioral sensitization at all ages tested. In preweanling rats, SCH23390, regardless of dose, was ineffective at preventing the induction of cocaine-, METH-, or NPA-induced one-trial behavioral sensitization.
  
  
  CONCLUSIONS
  The present results are in partial contrast to adult rodent studies, in which SCH23390 blocks the induction of METH- and apomorphine-induced behavioral sensitization, but not cocaine sensitization. When these findings are considered together, it appears that D1 receptor stimulation is not necessary for the induction of behavioral sensitization during the preweanling period, although D1 receptors may play a more important role in adulthood.
authors.affiliation: Department of Psychology, California State University, 5500 University Parkway, San Bernardino, CA, 92407, USA.
authors.forename: Alena
authors.initials: A
authors.lastname: Mohd-Yusof
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Gonzalez
authors.forename: Ana
authors.initials: A
authors.lastname: Veliz
authors.forename: Sanders A
authors.initials: SA
authors.lastname: McDougall
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D001058:Apomorphine / Q000031:analogs & derivatives / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D001552:Benzazepines / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology*; D005260:Female; D007858:Learning / Q000187:drug effects*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000378:metabolism*
chemical_list: D001552:Benzazepines; D000697:Central Nervous System Stimulants; D018491:Dopamine Agonists; D017447:Receptors, Dopamine D1; C534628:SCH 23390; D008694:Methamphetamine; C009074:N-n-propylnorapomorphine; D003042:Cocaine; D001058:Apomorphine
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