title: A novel poly(amido amine)-dendrimer-based hydrogel as a mimic for the extracellular matrix.
abstract: The extracellular matrix is mimicked by a novel dendrimer-based hydrogel, which exhibits a highly interconnected porous network, enhanced mechanical stiffness, and a low swelling ratio. The hydrogel system supports the proliferation and differentiation of mesenchymal stem cells without any cytotoxic effects. This dendrimer-based hydrogel may serve as a model for developing new advanced materials with applications in tissue engineering.
authors.affiliation: Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.forename: He
authors.initials: H
authors.lastname: Zhang
authors.forename: Sheng
authors.initials: S
authors.lastname: Yang
authors.forename: Xinru
authors.initials: X
authors.lastname: Jia
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D002478:Cells, Cultured; D050091:Dendrimers / Q000737:chemistry*; D005109:Extracellular Matrix / Q000737:chemistry* / Q000000981:diagnostic imaging*; D020100:Hydrogels / Q000138:chemical synthesis; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000502:physiology; D051379:Mice; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*; D014463:Ultrasonography
chemical_list: D050091:Dendrimers; D020100:Hydrogels; C104700:PAMAM Starburst; D011091:Polyesters; C499774:polyethylene glycol-polylactide-polyethylene glycol; D011092:Polyethylene Glycols
keywords: biomedical applications; dendrimers; extracellular matrix; hydrogels; tissue engineering