title: Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds.
abstract: Three heterocyclic hypervalent organoantimony chlorides RN(CH2C6H4)2SbCl (2a R = t-Bu, 2b R = Cy, 2c R = Ph) and their chalcogenide derivatives [RN(CH2C6H4)2Sb]2O (3a R = t-Bu, 3b R = Cy, 3c R = Ph) were synthesized and characterized by techniques such as (1)H NMR, (13)C NMR, X-ray diffraction, and elemental analysis. It is found that the anti-proliferative activity detected over these compounds can be attributed to the coordination bond between the antimony and nitrogen atoms of these compounds. Moreover, a preliminary study on mechanistic action suggests that the inhibition effect is ascribable to cell cycle arrest and cell apoptosis.
authors.affiliation: School of Basic Medicine, Central South University, Changsha 410013, PR China; Medical College, Hunan University of Chinese Medicine, Changsha 410208, PR China; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
authors.forename: Kun
authors.initials: K
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
authors.forename: Nian-Yuan
authors.initials: NY
authors.lastname: Tan
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
authors.forename: Ren-Hua
authors.initials: RH
authors.lastname: Qiu
authors.affiliation: School of Basic Medicine, Central South University, Changsha 410013, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
authors.forename: Ning-Lin
authors.initials: NL
authors.lastname: Luo
authors.affiliation: Medical College, Hunan University of Chinese Medicine, Changsha 410208, PR China.
authors.forename: Le
authors.initials: L
authors.lastname: Tong
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China; Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China.
authors.forename: Chak-Tong
authors.initials: CT
authors.lastname: Au
authors.affiliation: School of Basic Medicine, Central South University, Changsha 410013, PR China. Electronic address: luozq1962@163.com.
authors.forename: Zi-Qiang
authors.initials: ZQ
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China. Electronic address: sf_yin@hnu.edu.cn.
authors.forename: Shuang-Feng
authors.initials: SF
authors.lastname: Yin
mesh_terms: D000965:Antimony / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D000965:Antimony
keywords: Anti-proliferative activity; Apoptosis; Cell cycle arrest; Characterization; Hypervalent organoantimony; Synthesis