title: A novel method for tinidazole detection using Mn-modified CdSe/CdS quantum dots as a luminescent probe.
abstract: A new method for the determination of tinidazole based on the fluorescence quenching of citrate-capped Mn-modified CdSe/CdS quantum dots was developed. In aqueous solution, the fluorescence of the quantum dots at 610 nm was quenched gradually with the increase of the concentration of tinidazole. Based on this, a simple, fast, low-cost and specific quantitative method for tinidazole detection was set up. Under optimal conditions, a good linearity was built between the fluorescence quenching of Mn-modified CdSe/CdS quantum dots and the concentration of tinidazole in the range of 4-400 microM with a correlation coefficient of 0.9998. The limit of detection (3sigma/K) was 0.4 microM. The proposed method was applied to the detections of tinidazole in tablets and injections with satisfactory results.
authors.forename: Yanzi
authors.initials: Y
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.forename: Fangdi
authors.initials: F
authors.lastname: Wei
authors.forename: Miao
authors.initials: M
authors.lastname: Hu
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.forename: Qin
authors.initials: Q
authors.lastname: Hu
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis*; D000994:Antitrichomonal Agents / Q000032:analysis*; D019187:Cadmium Compounds / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D057230:Limit of Detection; D049449:Luminescence; D046529:Microscopy, Electron, Transmission; D015335:Molecular Probes; D045663:Quantum Dots; D018036:Selenium Compounds / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry*; D053719:Tandem Mass Spectrometry; D014011:Tinidazole / Q000032:analysis*
chemical_list: D000890:Anti-Infective Agents; D000994:Antitrichomonal Agents; D019187:Cadmium Compounds; D015335:Molecular Probes; D018036:Selenium Compounds; D013440:Sulfides; D014011:Tinidazole; C034939:cadmium sulfide; C058667:cadmium selenide