title: National dengue surveillance in the Lao People's Democratic Republic, 2006-2012: epidemiological and laboratory findings.
abstract: Although dengue has been a public health problem for several decades in the Lao People's Democratic Republic, the magnitude of the disease burden and epidemiological trends remain poorly understood. We analysed national dengue surveillance and laboratory data from 2006 to 2012 by person, place and time. Between 2006 and 2012, the annual dengue notification rate ranged between 62 and 367 cases per 100 000 population with an apparent geographical expansion of transmission throughout the country in recent years and concurrent co-circulation of all four dengue virus subtypes. An electronic database, called Lao People's Democratic Republic Early Warning Alert and Response Network, was introduced in 2008 to provide automated early warning for outbreaks and epidemics. Village outbreaks continue to be notified primarily through event-based surveillance, whereas the weekly indicator-based system provides systematic assessment of annual epidemic cycles. The dengue case data indicate a high and increasing burden of disease. Efforts now need to focus on using available data to prompt more effective outbreak response and to guide the design and implementation of intervention strategies.
authors.affiliation: National Center for Laboratory and Epidemiology (NCLE), Ministry of Health, Lao People's Democratic Republic.
authors.forename: Bouaphanh
authors.initials: B
authors.lastname: Khampapongpane
authors.affiliation: Emerging Disease Surveillance and Response Unit, World Health Organization, Lao People's Democratic Republic.
authors.forename: Hannah C
authors.initials: HC
authors.lastname: Lewis
authors.affiliation: National Center for Laboratory and Epidemiology (NCLE), Ministry of Health, Lao People's Democratic Republic. ; Emerging Disease Surveillance and Response Unit, World Health Organization, Lao People's Democratic Republic.
authors.forename: Pakapak
authors.initials: P
authors.lastname: Ketmayoon
authors.affiliation: National Center for Laboratory and Epidemiology (NCLE), Ministry of Health, Lao People's Democratic Republic.
authors.forename: Darouny
authors.initials: D
authors.lastname: Phonekeo
authors.affiliation: National Center for Laboratory and Epidemiology (NCLE), Ministry of Health, Lao People's Democratic Republic.
authors.forename: Virasack
authors.initials: V
authors.lastname: Somoulay
authors.affiliation: National Center for Laboratory and Epidemiology (NCLE), Ministry of Health, Lao People's Democratic Republic.
authors.forename: Amphai
authors.initials: A
authors.lastname: Khamsing
authors.affiliation: Emerging Disease Surveillance and Response Unit, World Health Organization, Lao People's Democratic Republic.
authors.forename: Manilay
authors.initials: M
authors.lastname: Phengxay
authors.affiliation: National Center for Laboratory and Epidemiology (NCLE), Ministry of Health, Lao People's Democratic Republic.
authors.forename: Thongchanh
authors.initials: T
authors.lastname: Sisouk
authors.affiliation: National Center for Laboratory and Epidemiology (NCLE), Ministry of Health, Lao People's Democratic Republic.
authors.forename: Phengta
authors.initials: P
authors.lastname: Vongphrachanh
authors.affiliation: Oxford University Clinical Research Unit, National Hospital for Tropical Diseases, Hanoi, Viet Nam . ; Nuffield Department of Medicine, Oxford University.
authors.forename: Juliet E
authors.initials: JE
authors.lastname: Bryant
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003715:Dengue / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D003716:Dengue Virus; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007812:Laos / Q000453:epidemiology; D008297:Male; D017720:Molecular Epidemiology; D011159:Population Surveillance; D013045:Species Specificity; D055815:Young Adult
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