title: Extensive warfarin-induced skin necrosis successfully treated with negative pressure wound therapy.
abstract: A 55-year-old woman presented with an extensive warfarin-induced skin necrosis while an inpatient for treatment of a pulmonary embolism and thromboembolic stroke. She had a background of diabetes mellitus, hypertension and dyslipidaemia. Her warfarin was stopped and she was anticoagulated with low-molecular weight heparin. The wound was successfully treated with a combination of antibiotic, debridement and negative pressure wound therapy.
authors.affiliation: Dermatology Department, Mater Misericordiae University Hospital, Dublin, Ireland.
authors.forename: Aizuri A
authors.initials: AA
authors.lastname: Murad
authors.forename: Toddy
authors.initials: T
authors.lastname: Daly
authors.forename: Niall
authors.initials: N
authors.lastname: Mulligan
authors.forename: Patsy
authors.initials: P
authors.lastname: Lenane
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D003875:Drug Eruptions / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced / Q000628:therapy; D054843:Negative-Pressure Wound Therapy; D012074:Remission Induction; D012867:Skin / Q000473:pathology*; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin
references.citation: J Urol. 1989 Apr;141(4):946-8
references.pmid: 2648033
references.citation: BMJ Case Rep. 2013 Jan 28;2013:
references.pmid: 23362073
references.citation: Burns Incl Therm Inj. 1988 Apr;14(2):139-41
references.pmid: 3292018
references.citation: Am J Clin Dermatol. 2005;6(3):185-94
references.pmid: 15943495
references.citation: South Med J. 1980 Nov;73(11):1470-2
references.pmid: 7444510