title: To estimate salivary aspartate aminotransferase levels in chronic gingivitis and chronic periodontitis patients prior to and following non-surgical periodontal therapy: A clinico-biochemical study.
abstract: BACKGROUND
  Saliva can be used as a diagnostic fluid in dentistry. Various enzymes have been proposed as markers for periodontal destruction. One of them is aspartate aminotransferase, for which salivary analysis can offer a cost-effective approach for monitoring the disease. Changes in enzymatic activity reflect metabolic changes in the gingiva and periodontium in inflammation.
  
  
  OBJECTIVE
  The purpose of this study was to assess the aspartate aminotransferase levels in saliva prior to and following scaling and root planning (SRP) at 1 month and 3 month interval and correlating it with the clinical parameters in generalized chronic gingivitis and chronic periodontitis patients.
  
  
  METHODS
  Thirty patients with generalized chronic gingivitis and 30 with generalized chronic periodontitis were selected. The activity of aspartate aminotransferase levels in saliva were assessed biochemically before and after SRP at 1 month and 3 months. The aspartate aminotransferase levels were correlated with clinical parameters (gingival index and probing depth).
  
  
  METHODS
  A paired t test was done.
  
  
  RESULTS
  A decrease in gingival index, probing depth, and aspartate aminotransferase levels were seen in both the groups at 1 and 3 months which was found to be statistically highly significant (P value 0.00). Aspartate aminotransferase levels were statistically significantly correlated with the clinical parameters at baseline (P < 0.05) but at 3 months, a positive correlation was seen in both the groups which was statistically insignificant (P > 0.05).
  
  
  CONCLUSIONS
  Elevated salivary aspartate aminotransferase levels were seen in generalized chronic gingivitis and chronic periodontitis patients, with higher values recorded in generalized chronic periodontitis correlating to the tissue destruction taking place in these conditions.
authors.affiliation: Department of Periodontics and Implantology, Jaipur Dental College, Jaipur, Rajasthan, India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Kudva
authors.affiliation: Department of Periodontics and Implantology, Jaipur Dental College, Jaipur, Rajasthan, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Saini
authors.affiliation: Department of Periodontics and Implantology, Jaipur Dental College, Jaipur, Rajasthan, India.
authors.forename: Hema
authors.initials: H
authors.lastname: Kudva
authors.affiliation: Department of Periodontics and Implantology, Jaipur Dental College, Jaipur, Rajasthan, India.
authors.forename: Varun
authors.initials: V
authors.lastname: Saini
keywords: Aspartate aminotransferase; diagnosis; periodontal destruction; saliva
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