title: Neuronal cell fate decisions:  O2 and CO2 sensing neurons require egl-13/Sox5.
abstract: We recently conducted a study that aimed to describe the differentiation mechanisms used to generate O2 and CO2 sensing neurons in C. elegans. We identified egl-13/Sox5 to be required for the differentiation of both O2 and CO2 sensing neurons. We found that egl-13 functions cell autonomously to drive O2 and CO2 sensing neuron fate and is therefore essential for O2 and CO2 sensing-induced behaviors. Through systematic dissection of the egl-13 promoter we identified upstream regulators of egl-13 and proposed a model of how differentiation of O2 and CO2 sensing neurons is regulated. In this commentary we discuss our findings and open questions we wish to address in future studies.
authors.affiliation: Biotech Research and Innovation Centre; University of Copenhagen; Ole Maaløes Vej 5; Copenhagen, Denmark.
authors.forename: Jakob
authors.initials: J
authors.lastname: Gramstrup Petersen
authors.affiliation: Biotech Research and Innovation Centre; University of Copenhagen; Ole Maaløes Vej 5; Copenhagen, Denmark.
authors.forename: Roger
authors.initials: R
authors.lastname: Pocock
keywords: BAG neurons; EGL-13; Sox5; URX neurons; neuronal diversity; neuronal specification; oxygen and carbon dioxide sensing
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