title: Novel syntheses of aryl quinoxaline C-nucleoside analogs by mild and efficient three-component sequential reactions.
abstract: Novel syntheses of C-nucleoside analogs with aryl quinoxalines as nucleobase surrogates have been accomplished by mild and efficient three-component sequential reactions in high yields with a wide scope of substrates. The mechanism was clarified by isolation of novel sugar 1,2-diketone derived from oxidation of the corresponding alkyne.
authors.affiliation: The College of Chemistry and Molecular Engineering, The Key Lab of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou 450052, China. zhangfy@zzu.edu.cn.
authors.forename: Fuyi
authors.initials: F
authors.lastname: Zhang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xi
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Lu
authors.forename: Liming
authors.initials: L
authors.lastname: Wang
authors.forename: Linwei
authors.initials: L
authors.lastname: Liu
authors.forename: Jinliang
authors.initials: J
authors.lastname: Li
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000480:Alkynes / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D009705:Nucleosides / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry; D011810:Quinoxalines / Q000737:chemistry*
chemical_list: D000480:Alkynes; D009705:Nucleosides; D009943:Organophosphorus Compounds; D011810:Quinoxalines; C434331:phosphoramidite; D004247:DNA