title: Studies on the antidiabetic activities of Cordyceps militaris extract in diet-streptozotocin-induced diabetic Sprague-Dawley rats.
abstract: Due to substantial morbidity and high complications, diabetes mellitus is considered as the third "killer" in the world. A search for alternative antidiabetic drugs from herbs or fungi is highly demanded. Our present study aims to investigate the antidiabetic activities of Cordyceps militaris on diet-streptozotocin-induced type 2 diabetes mellitus in rats. Diabetic rats were orally administered with water extract or alcohol extract at 0.05 g/kg and 2 g/kg for 3 weeks, and then, the factors levels related to blood glucose, lipid, free radicals, and even nephropathy were determined. Pathological alterations on liver and kidney were examined. Data showed that, similar to metformin, Cordyceps militaris extracts displayed a significant reduction in blood glucose levels by promoting glucose metabolism and strongly suppressed total cholesterol and triglycerides concentration in serum. Cordyceps militaris extracts exhibit antioxidative effects indicated by normalized superoxide dismutase and glutathione peroxidase levels. The inhibitory effects on blood urea nitrogen, creatinine, uric acid, and protein revealed the protection of Cordyceps militaris extracts against diabetic nephropathy, which was confirmed by pathological morphology reversion. Collectively, Cordyceps militaris extract, a safe pharmaceutical agent, presents excellent antidiabetic and antinephropathic activities and thus has great potential as a new source for diabetes treatment.
authors.affiliation: College of Life Science, Jilin University, Changchun 130012, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Dong
authors.affiliation: College of Life Science, Jilin University, Changchun 130012, China.
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Jing
authors.affiliation: College of Life Science, Jilin University, Changchun 130012, China.
authors.forename: Qingfan
authors.initials: Q
authors.lastname: Meng
authors.affiliation: College of Life Science, Jilin University, Changchun 130012, China.
authors.forename: Chungang
authors.initials: C
authors.lastname: Liu
authors.affiliation: College of Life Science, Jilin University, Changchun 130012, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Hu
authors.affiliation: College of Clinical Medicine, Jilin University, Changchun 130012, China.
authors.forename: Yihang
authors.initials: Y
authors.lastname: Ma
authors.affiliation: College of Life Science, Jilin University, Changchun 130012, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Life Science, Jilin University, Changchun 130012, China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Lu
authors.affiliation: College of Life Science, Jilin University, Changchun 130012, China.
authors.forename: Yingkun
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: College of Life Science, Jilin University, Changchun 130012, China.
authors.forename: Di
authors.identifier: 0000-0002-7322-4174
authors.initials: D
authors.lastname: Wang
authors.affiliation: College of Life Science, Jilin University, Changchun 130012, China ; College of Life Science, Zhuhai College of Jilin University, Zhuhai 519000, China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Teng
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D032661:Cordyceps / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D003928:Diabetic Nephropathies / Q000188:drug therapy; D004032:Diet / Q000379:methods; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D008055:Lipids; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008055:Lipids; D013311:Streptozocin
references.citation: J Sci Food Agric. 2011 Jun;91(8):1446-51
references.pmid: 21384377
references.citation: Environ Res. 2005 Nov;99(3):335-43
references.pmid: 16307975
references.citation: Folia Med (Plovdiv). 2013 Jan-Mar;55(1):83-92
references.pmid: 23905492
references.citation: J Diabetes Investig. 2011 Aug 2;2(4):243-7
references.pmid: 24843491
references.citation: Toxicol Lett. 2006 Jul 14;164(3):214-20
references.pmid: 16460892
references.citation: Appl Microbiol Biotechnol. 2006 Oct;72(6):1152-6
references.pmid: 16575562
references.citation: Phytochemistry. 2008 May;69(7):1469-95
references.pmid: 18343466
references.citation: J Anim Physiol Anim Nutr (Berl). 2008 Feb;92(1):105-11
references.pmid: 18184386
references.citation: Exp Diabetes Res. 2008;2008:704045
references.pmid: 19132099
references.citation: Biol Pharm Bull. 1996 Feb;19(2):294-6
references.pmid: 8850325
references.citation: Diabetes Res Clin Pract. 1997 May;36(2):113-9
references.pmid: 9229195
references.citation: Biosci Biotechnol Biochem. 2004 Nov;68(11):2257-64
references.pmid: 15564662
references.citation: Biol Pharm Bull. 2006 Jul;29(7):1418-22
references.pmid: 16819181
references.citation: J Ethnopharmacol. 2011 Mar 24;134(2):422-8
references.pmid: 21211558
references.citation: Rev Endocr Metab Disord. 2004 Aug;5(3):237-48
references.pmid: 15211095
references.citation: Food Chem. 2011 Dec 1;129(3):871-6
references.pmid: 25212312
references.citation: Fitoterapia. 2010 Jul;81(5):397-402
references.pmid: 19969045
references.citation: J Ethnopharmacol. 2002 Jul;81(2):239-44
references.pmid: 12065157
references.citation: Histochemistry. 1993 May;99(5):385-90
references.pmid: 7687595
references.citation: Acta Biochim Pol. 2008;55(2):391-8
references.pmid: 18511986
references.citation: Comp Med. 2004 Jun;54(3):252-7
references.pmid: 15253270
references.citation: J Sci Food Agric. 2011 Aug 30;91(11):2095-9
references.pmid: 21567411
references.citation: Evid Based Complement Alternat Med. 2013;2013:786528
references.pmid: 23533520
references.citation: J Ethnopharmacol. 2006 Apr 6;104(3):306-9
references.pmid: 16271836
references.citation: J Ethnopharmacol. 2008 Jan 17;115(2):173-83
references.pmid: 18068921
references.citation: Diabetes Res Clin Pract. 2013 Jun;100(3):409-10
references.pmid: 23731592
references.citation: J Periodontol. 2008 May;79(5):774-83
references.pmid: 18454655
references.citation: J Ethnopharmacol. 2008 Dec 8;120(3):366-71
references.pmid: 18929637
references.citation: Diabetes Res Clin Pract. 2012 Jan;95(1):1-9
references.pmid: 22000494
references.citation: Indian J Clin Biochem. 2006 Mar;21(1):126-30
references.pmid: 23105583
references.citation: Phytomedicine. 2006 Jun;13(6):428-33
references.pmid: 16716913
references.citation: Diabetes Metab. 2007 Feb;33(1):3-12
references.pmid: 17258489
references.citation: Evid Based Complement Alternat Med. 2012;2012:743107
references.pmid: 22474523
references.citation: Afr J Tradit Complement Altern Med. 2011;8(3):275-83
references.pmid: 22468006
references.citation: Clin Ther. 2011 Aug;33(8):1005-22
references.pmid: 21802144
references.citation: Life Sci. 2003 Sep 26;73(19):2503-13
references.pmid: 12954458
references.citation: J Immunotoxicol. 2008 Jan;5(1):47-57
references.pmid: 18382858
references.citation: J Biol Chem. 2001 May 11;276(19):16033-9
references.pmid: 11340083
references.citation: Phytother Res. 2012 Aug;26(8):1173-7
references.pmid: 22821853
references.citation: Health Technol Assess. 2011 May;15 Suppl 1:77-86
references.pmid: 21609656
references.citation: Biol Pharm Bull. 2006 Jun;29(6):1167-74
references.pmid: 16755011
references.citation: Biol Pharm Bull. 2003 Jan;26(1):84-7
references.pmid: 12520179
references.citation: Semin Nephrol. 2007 Mar;27(2):195-207
references.pmid: 17418688
references.citation: J Ethnopharmacol. 2008 Jan 17;115(2):276-83
references.pmid: 18024034