title: C-terminal tensin-like (CTEN): a promising biomarker and target for cancer.
abstract: C-terminal tensin-like (cten, also known as tensin4, TNS4) is a member of the tensin family. Cten protein, like the other three tensin family members, localizes to focal adhesion sites but only shares sequence homology with other tensins at its C-terminal region, which contains the SH2 and PTB domains. Cten is abundantly expressed in normal prostate and placenta and is down-regulated in prostate cancer. However, overexpression of cten frequently associates with tumors derived from breast, colon, lung, stomach, skin and pancreas. A variety of cancer-associated growth factors and cytokines induce cten expression. Up-regulated cten promotes cell motility, prolongs epidermal growth factor receptor signaling, and enhances tumorigenicity. Emerging findings suggest that cten is a promising biomarker and therapeutic target for various cancers.
authors.affiliation: Department of Biochemistry and Molecular Medicine, University of California-Davis, Sacramento, CA 95817, United States. Electronic address: shlo@ucdavis.edu.
authors.forename: Su Hao
authors.initials: SH
authors.lastname: Lo
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D022001:Focal Adhesions / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D000070876:Tensins
chemical_list: D014408:Biomarkers, Tumor; D008840:Microfilament Proteins; C000603371:TNS4 protein, human; D000070876:Tensins
keywords: Cten; Focal adhesion; Tensin; Tumor promoter; Tumor suppressor
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