title: Porphyromonas gingivalis: major periodontopathic pathogen overview.
abstract: Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. This anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. The purpose of this review is to provide an overview of one of the main periodontal pathogens-Porphyromonas gingivalis. This bacterium, along with Treponema denticola and Tannerella forsythia, constitute the "red complex," a prototype polybacterial pathogenic consortium in periodontitis. This review outlines Porphyromonas gingivalis structure, its metabolism, its ability to colonize the epithelial cells, and its influence upon the host immunity.
authors.affiliation: Institute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech Republic.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Mysak
authors.affiliation: Institute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech Republic.
authors.forename: Stepan
authors.initials: S
authors.lastname: Podzimek
authors.affiliation: Institute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech Republic.
authors.forename: Pavla
authors.initials: P
authors.lastname: Sommerova
authors.affiliation: Institute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech Republic.
authors.forename: Yelena
authors.initials: Y
authors.lastname: Lyuya-Mi
authors.affiliation: Institute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech Republic.
authors.forename: Jirina
authors.initials: J
authors.lastname: Bartova
authors.affiliation: Institute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech Republic.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Janatova
authors.affiliation: Institute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech Republic.
authors.forename: Jarmila
authors.initials: J
authors.lastname: Prochazkova
authors.affiliation: Institute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Duskova
mesh_terms: D016866:Bacteroidaceae Infections / Q000276:immunology / Q000378:metabolism / Q000382:microbiology*; D006801:Humans; D010518:Periodontitis / Q000276:immunology / Q000378:metabolism / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000472:pathogenicity / Q000502:physiology*
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