title: Anti-Trypanosoma cruzi activity of 10 medicinal plants used in northeast Mexico.
abstract: The aim of this study was to screen the trypanocidal activity of plants used in traditional Mexican medicine for the treatment of various diseases related to parasitic infections. Cultured Trypanosoma cruzi epimastigotes were incubated for 96h with different concentrations of methanolic extracts obtained from Artemisia mexicana, Castela texana, Cymbopogon citratus, Eryngium heterophyllum, Haematoxylum brasiletto, Lippia graveolens, Marrubium vulgare, Persea americana, Ruta chalepensis and Schinus molle. The inhibitory concentration (IC50) was determined for each extract via a colorimetric method. Among the evaluated species, the methanolic extracts of E. heterophyllum, H. brasiletto, M. vulgare and S. molle exhibited the highest trypanocidal activity, showing percentages of growth inhibition between 88 and 100% at a concentration of 150μg/ml. These medicinal plants may represent a valuable source of new bioactive compounds for the therapeutic treatment of trypanosomiasis.
authors.affiliation: Universidad Autónoma de Nuevo León, UANL, Facultad de Ciencias Biológicas, Laboratorio de Patología Molecular, Ave. Universidad S/N, Cd. Universitaria, 66451 San Nicolás de los Garza, NL, Mexico.
authors.forename: Zinnia Judith
authors.initials: ZJ
authors.lastname: Molina-Garza
authors.affiliation: Universidad Autónoma de Nuevo León, UANL, Facultad de Ciencias Biológicas, Laboratorio de Fitoquímica, Ave. Universidad S/N, Cd. Universitaria, 66451 San Nicolás de los Garza, NL, Mexico.
authors.forename: Aldo Fabio
authors.initials: AF
authors.lastname: Bazaldúa-Rodríguez
authors.affiliation: Universidad Autónoma de Nuevo León, UANL, Facultad de Ciencias Biológicas, Laboratorio de Fitoquímica, Ave. Universidad S/N, Cd. Universitaria, 66451 San Nicolás de los Garza, NL, Mexico.
authors.forename: Ramiro
authors.initials: R
authors.lastname: Quintanilla-Licea
authors.affiliation: Universidad Autónoma de Nuevo León, UANL, Facultad de Ciencias Biológicas, Laboratorio de Patología Molecular, Ave. Universidad S/N, Cd. Universitaria, 66451 San Nicolás de los Garza, NL, Mexico. Electronic address: lucio.galavizsl@uanl.edu.mx.
authors.forename: Lucio
authors.initials: L
authors.lastname: Galaviz-Silva
mesh_terms: D008519:Medicine, Traditional; D008800:Mexico; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D014344:Trypanocidal Agents
keywords: Chagas disease; Medicinal plants; Trypanocidal activity