title: Lack of significant elevation of myeloid-derived suppressor cells in peripheral blood of chronically hepatitis C virus-infected individuals.
abstract: Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with immunosuppressive function. Compared to the level in healthy controls (HC), no elevation of MDSC in chronic hepatitis C (cHEP-C) patients was found, and there was no difference in MDSC based on genotype or viral load (P > 0.25). Moreover, MDSC of cHEP-C patients inhibited CD8 T cell function as efficiently as MDSC of HC did. Since we detected neither quantitative nor qualitative differences in MDSC of cHEP-C patients relative to those of HC, we postulate that MDSC in peripheral blood are most likely not significant regarding immune dysfunction in cHEP-C.
authors.affiliation: Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Nonnenmann
authors.affiliation: Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany.
authors.forename: Renate
authors.initials: R
authors.lastname: Stirner
authors.affiliation: Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Roider
authors.affiliation: Leberzentrum Prof. Dr. Jung und Dr. Fischer, Munich, Germany.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Jung
authors.affiliation: Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Schrödl
authors.affiliation: Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany.
authors.forename: Johannes R
authors.initials: JR
authors.lastname: Bogner
authors.affiliation: Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany rika.draenert@med.uni-muenchen.de.
authors.forename: Rika
authors.initials: R
authors.lastname: Draenert
mesh_terms: D017951:Antigen Presentation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005434:Flow Cytometry; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D019698:Hepatitis C, Chronic / Q000097:blood / Q000276:immunology* / Q000821:virology; D006801:Humans; D016130:Immunophenotyping; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D022423:Myeloid Cells / Q000276:immunology* / Q000378:metabolism; D019562:Viral Load / Q000276:immunology*
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