title: Toll-like receptor 10-1-6 gene cluster polymorphisms are not associated with benign prostatic hyperplasia in korean population.
abstract: OBJECTIVE
  Inflammation and infection have been associated with the pathogenesis of benign prostatic hyperplasia (BPH). Toll-like receptors (TLRs) play key roles in the innate immune system and initiate the inflammatory response to foreign pathogens. We investigated the relationship between TLR10-1-6 gene cluster polymorphisms and BPH.
  
  
  METHODS
  We genotyped four promoter single nucleotide polymorphisms (SNPs) (TLR10, rs10004195; TLR1, rs5743557; and TLR6, rs1039560 and rs1039559) by directly sequencing (233 BPH patients and 214 control subjects). SNPStats and Haploview version 4.02 were used to analyze the data. Multiple logistic regression models (log-additive, dominant, and recessive) were performed to determine odds ratios (ORs), 95% confidence intervals (CIs), and P-values.
  
  
  RESULTS
  The genotype and allele frequencies of each SNP was not different between the BPH and control groups (P>0.05). Haplotype analysis showed no association between the haplotype in the linkage disequilibrium (LD) block and BPH (P>0.05), although the LD block was constructed.
  
  
  CONCLUSIONS
  These results indicate that the TLR10-1-6 gene cluster may be not associated with the development of BPH in the Korean population.
authors.affiliation: Department of Pharmacology, Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Development of Ginseng and Medical Plants Research Institute, Rural Administration, Eumseong, Korea.
authors.forename: Young Ock
authors.initials: YO
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Kyung Hee University College of Oriental Medicine, Seoul, Korea.
authors.forename: Byung-Cheol
authors.initials: BC
authors.lastname: Lee
authors.affiliation: Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Koo Han
authors.initials: KH
authors.lastname: Yoo
authors.affiliation: Department of Pharmacology, Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
keywords: Prostatic hyperplasia; Single nucleotide polymorphism; Toll-like receptors
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