title: The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia.
abstract: OBJECTIVE
  Preeclampsia is associated with alterations in the maternal renin-angiotensin-aldosterone system (RAAS), increased blood pressure (BP), and cardiovascular risk in the offspring. We hypothesized that preeclampsia is associated with alterations in the RAAS in the offspring that persist into adolescence.
  
  
  METHODS
  We compared components of the circulating (n = 111) and renal (n = 160) RAAS in adolescents born prematurely with very low birth weight (VLBW) of preeclamptic (PreE) and normotensive (NoHTN) pregnancies. Multivariable linear regression was used to evaluate potential confounding and intermediate variables. Analyses were stratified by sex.
  
  
  RESULTS
  Adjusting for race and antenatal steroid exposure, male offspring of PreE mothers had higher circulating aldosterone than those of NoHTN mothers (adjusted mean difference = 109; 95% confidence limits: -9, 227 pmol/L). Further adjustment for current BMI attenuated this difference (adjusted mean difference: 93; 95% confidence limits: -30, 215 pmol/L).
  
  
  CONCLUSIONS
  Among male preterm VLBW infants, maternal preeclampsia is associated with increased circulating aldosterone level in adolescence, which appears to be mediated in part by higher BMI.
authors.affiliation: Department of Pediatrics, Wake Forest School of Medicine, USA Hypertension and Vascular Research Center, Wake Forest School of Medicine, USA liwashbu@wakehealth.edu.
authors.forename: Lisa K
authors.initials: LK
authors.lastname: Washburn
authors.affiliation: Hypertension and Vascular Research Center, Wake Forest School of Medicine, USA.
authors.forename: K Bridget
authors.initials: KB
authors.lastname: Brosnihan
authors.affiliation: Hypertension and Vascular Research Center, Wake Forest School of Medicine, USA.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Chappell
authors.affiliation: Hypertension and Vascular Research Center, Wake Forest School of Medicine, USA.
authors.forename: Debra I
authors.initials: DI
authors.lastname: Diz
authors.affiliation: Hypertension and Vascular Research Center, Wake Forest School of Medicine, USA.
authors.forename: TanYa M
authors.initials: TM
authors.lastname: Gwathmey
authors.affiliation: Department of Pediatrics, Wake Forest School of Medicine, USA Health and Exercise Science, Wake Forest School of Medicine, USA.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Nixon
authors.affiliation: Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, USA.
authors.forename: Gregory B
authors.initials: GB
authors.lastname: Russell
authors.affiliation: Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, USA.
authors.forename: Beverly M
authors.initials: BM
authors.lastname: Snively
authors.affiliation: Department of Pediatrics, Wake Forest School of Medicine, USA Hypertension and Vascular Research Center, Wake Forest School of Medicine, USA.
authors.forename: T Michael
authors.initials: TM
authors.lastname: O'Shea
mesh_terms: D000293:Adolescent; D000450:Aldosterone / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000097:blood; D008297:Male; D009035:Mothers; D015999:Multivariate Analysis; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D047928:Premature Birth / Q000097:blood*; D012084:Renin-Angiotensin System
chemical_list: D000450:Aldosterone
keywords: Very low birth weight; fetal programming; prematurity; preterm birth; sex differences
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