title: NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis.
abstract: BACKGROUND
  A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene and the risk for MS in the Greek population. The aim of this study was to replicate a possible influence of the. SNP rs1800566 in the NQO1 gene in the risk for MS in the Spanish Caucasian population.
  
  
  METHODS
  We analyzed allelic and genotypic frequency of NQO1 rs1800566 in 290 patients with MS and 310 healthy controls, using TaqMan Assays.
  
  
  RESULTS
  NQO1 rs1800566 allelic and genotypic frequencies did not differ significantly between MS patients and controls, and were unrelated with age of onset of MS, gender, and clinical type of MS.
  
  
  CONCLUSIONS
  Our results indicate that NQO1 rs1800566 does not have an effect on MS disease risk.
authors.forename: José A G
authors.initials: JA
authors.lastname: Agúndez
authors.forename: Elena
authors.initials: E
authors.lastname: García-Martín
authors.forename: Carmen
authors.initials: C
authors.lastname: Martínez
authors.forename: Julián
authors.initials: J
authors.lastname: Benito-León
authors.forename: Jorge
authors.initials: J
authors.lastname: Millán-Pascual
authors.forename: Patricia
authors.initials: P
authors.lastname: Calleja
authors.forename: María
authors.initials: M
authors.lastname: Díaz-Sánchez
authors.forename: Diana
authors.initials: D
authors.lastname: Pisa
authors.forename: Laura
authors.initials: L
authors.lastname: Turpín-Fenoll
authors.forename: Hortensia
authors.initials: H
authors.lastname: Alonso-Navarro
authors.forename: Lucía
authors.initials: L
authors.lastname: Ayuso-Peralta
authors.forename: Dolores
authors.initials: D
authors.lastname: Torrecillas
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Plaza-Nieto
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain. fjavier.jimenez@salud.madrid.org.
authors.forename: Félix Javier
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013030:Spain
chemical_list: D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human
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