title: [Relationship of mid-trimester serum screening markers and adverse pregnancy outcomes].
abstract: OBJECTIVE
  To explore the relationship of mid-trimester serum screening markers and adverse pregnancy outcomes.
  
  
  METHODS
  We retrospectively reviewed all obstetric patients with mid-trimester screening data who delivered at our department from September 2010 to November 2012. Adjusted effects were estimated with Logistic regression analysis.
  
  
  RESULTS
  A total of 3 618 cases were enrolled. The level of free β-subunit of human chorionic gonadotropin (fβ-hCG) [ ≥ 2.2 (multiple of median) MOM] was associated with the risk of pregnancy-related hypertension (OR = 2.06, 95%CI 1.18-3.60, P < 0.01). And fβ-hCG ( ≥ 2.2 MOM) and alpha-fetoprotein (AFP) ( ≥ 1.88 MOM) were associated with the development of placenta-related complications (P < 0.01, 0.05 respectively). Additionally, maternal weight was associated with the risk of pregnancy-related hypertension and placenta-related complications (both P < 0.05).
  
  
  CONCLUSIONS
  The mid-trimester screening markers fβ-hCG and AFP are associated the risk of adverse pregnancy outcomes. And their value may predict the risk of adverse pregnancy outcomes.
authors.affiliation: Department of Obstetrics & Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. Email: zhangyang@coga.org.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics & Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhai
authors.affiliation: Department of Obstetrics & Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Obstetrics & Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Obstetrics & Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Junli
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Obstetrics & Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D012307:Risk Factors; D055815:Young Adult; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins