title: Obesity and the risk of cholangiocarcinoma: a meta-analysis.
abstract: A number of studies have shown that obesity is implicated in the susceptibility to several cancers. However, the association between obesity and cholangiocarcinoma remains unclear. This meta-analysis aimed to quantitatively assess the association between overweight or obesity and the incidence of cholangiocarcinoma. A literature search was performed for cohort and case-control studies published from 1996 to 2013 using PubMed, Cochrane, and EMBASE databases. Studies were included if they reported odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) of cholangiocarcinoma with respect to obesity or overweight. Normal weight, overweight, and obesity were defined when the body mass index (BMI) was 18.5-24.9, 25-29.9, and ≥ 30 kg/m(2), respectively. Excess body weight was defined as BMI ≥ 25 kg/m(2). Ten studies met the inclusion criteria, which included five cohort and five case-control studies. Compared with normal weight, being overweight (pooled OR 1.30, 95 % CI 1.13-1.49), obesity (pooled OR 1.52, 95 % CI 1.13-1.89), and excess body weight (pooled OR 1.37, 95 %CI 1.22-1.55) were significantly associated with cholangiocarcinoma. The funnel plot revealed no evidence for publication bias. Obesity is associated with the increased risk of cholangiocarcinoma, which needs to be confirmed by long-term cohort studies.
authors.affiliation: Department of Gastroenterology, Shandong Provincial Hospital, Shandong University, 324 Jing 5 Road, Jinan, 250021, Shandong, China.
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Li
authors.forename: Tian-Jie
authors.initials: TJ
authors.lastname: Han
authors.forename: Nie
authors.initials: N
authors.lastname: Jing
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Zhang
authors.forename: Feng-Zhen
authors.initials: FZ
authors.lastname: Ma
authors.forename: Ji-Yong
authors.initials: JY
authors.lastname: Liu
mesh_terms: D015992:Body Mass Index; D016022:Case-Control Studies; D018281:Cholangiocarcinoma / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D009765:Obesity / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D050177:Overweight; D012307:Risk Factors
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