title: New GO-PEI-Au-L-Cys ZIC-HILIC composites: synthesis and selective enrichment of glycopeptides.
abstract: GO-PEI-Au-L-Cys composites were synthesized via loading gold nanoparticles on a GO surface using polyethylenimine as reducing and stabilizing reagents, followed by L-cysteine immobilization through an Au-S bond. The composites were applied as a kind of novel ZIC-HILIC material to achieve highly selective enrichment of glycopeptides from biological samples.
authors.affiliation: National Chromatographic R & A Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Yu
authors.initials: Y
authors.lastname: Liang
authors.forename: Qi
authors.initials: Q
authors.lastname: Wu
authors.forename: Hao
authors.initials: H
authors.lastname: Jiang
authors.forename: Kaiguang
authors.initials: K
authors.lastname: Yang
authors.forename: Lihua
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liang
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Peng
authors.forename: Yukui
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D002850:Chromatography, Gel; D003545:Cysteine / Q000737:chemistry*; D006020:Glycopeptides / Q000032:analysis / Q000302:isolation & purification*; D006046:Gold / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007074:Immunoglobulin G / Q000378:metabolism; D053761:Nanocomposites / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D006020:Glycopeptides; D007074:Immunoglobulin G; D010087:Oxides; D006046:Gold; D006108:Graphite; D011094:Polyethyleneimine; D003545:Cysteine