title: Relationship between interleukin-10 -1082A/G polymorphism and risk of ischemic stroke: a meta-analysis.
abstract: OBJECTIVE
  To analyze the association between -1082A/G polymorphism in interleukin-10 (IL-10) gene and ischemic stroke (IS) risk by meta-analysis.
  
  
  METHODS
  We carried out a systematic electronic search in PubMed, BIOSIS Previews, Science Direct, Chinese National Knowledge Infrastructure, Chinese Biomedical Database, Weipu database and WANGFANG Database. Pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated to assess the strength of the association.
  
  
  RESULTS
  7 studies were included. There was no significant association between IL-10 -1082A/G polymorphism and IS risk under all genetic models in overall estimates (A vs. G: OR = 1.23,95%CI = 0.85-1.79;AA vs. GG: OR = 1.01,95%CI = 0.47-2.19; AG vs. GG: OR = 0.76, 95%CI = 0.38-1.55; AA+AG vs. GG: OR = 0.89,95%CI = 0.46-1.73; AA vs. AG+GG: OR = 1.39, 95%CI = 0.91-2.13). Similarly, no associations were found in subgroup analysis based on ethnicity and source of controls. However, removing the study deviating from Hardy-Weinberg equilibrium (HWE) produced statistically significant associations for overall estimates under recessive model(AA VS. AG+GG OR 1.58, 95% CI 1.04-2.42) and among Asians in all genetic models (A VS.G OR 1.64, 95% CI 1.07-2.53; AA vs. GG OR1.91, 95% CI 1.31-2.80; AG vs. GG OR1.44, 95% CI 1.09-1.91; AA+AG vs. GG OR 1.54, 95% CI 1.18-2.01;AA VS. AG+GG OR 1.79, 95% CI 1.07-3.00). Even after Bonferroni correction, the associations were observed still significantly in Asians under the two models (AA vs. GG OR1.91, 95% CI 1.31-2.80, P = 0.0008; AA+AG vs. GG OR 1.54, 95% CI 1.18-2.01, P = 0.001).
  
  
  CONCLUSIONS
  This meta-analysis indicates that IL10 -1082 A/G polymorphism is associated with IS susceptibility in Asians and the -1082 A allele may increase risk of IS in Asians. Considering the sample size is small and between-study heterogeneity is remarkable, more studies with subtle design are warranted in future.
authors.affiliation: Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, China; Department of Neurology, Zhumadian zhongxin Hospital, Zhumadian, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Wuying
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Neurology, The First People's Hospital of Foshan, Foshan, China.
authors.forename: Lingmei
authors.initials: L
authors.lastname: Peng
authors.affiliation: Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Peihua
authors.initials: P
authors.lastname: Wu
authors.affiliation: Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Tan
mesh_terms: D000483:Alleles; D044466:Asian People; D002681:China; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D007511:Ischemia / Q000235:genetics*; D015233:Models, Statistical; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000235:genetics*
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
references.citation: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references.pmid: 13655060
references.citation: J Vasc Surg. 2010 Jul;52(1):103-9
references.pmid: 20385468
references.citation: Stat Med. 2005 May 15;24(9):1291-306
references.pmid: 15568190
references.citation: PLoS Med. 2009 Jul 21;6(7):e1000097
references.pmid: 19621072
references.citation: Nat Med. 2009 Feb;15(2):192-9
references.pmid: 19169263
references.citation: Eur J Neurol. 2011 Apr;18(4):637-43
references.pmid: 20880001
references.citation: PLoS One. 2013;8(3):e57305
references.pmid: 23505425
references.citation: Stat Med. 1996 Jun 30;15(12):1237-48; discussion 1249-52
references.pmid: 8817798
references.citation: J Genet. 2011 Aug;90(2):361-4
references.pmid: 21869490
references.citation: Ir J Med Sci. 2004 Oct-Dec;173(4):200-3
references.pmid: 16323614
references.citation: Eur Cytokine Netw. 2002 Jan-Mar;13(1):66-71
references.pmid: 11956022
references.citation: Cerebrovasc Dis. 2009;27(5):493-501
references.pmid: 19342825
references.citation: Mol Biol Rep. 2013 Feb;40(2):1785-90
references.pmid: 23096091
references.citation: Atherosclerosis. 2004 Dec;177(2):409-14
references.pmid: 15530917
references.citation: BMJ. 1994 Nov 19;309(6965):1351-5
references.pmid: 7866085
references.citation: Biochem Genet. 2008 Feb;46(1-2):64-74
references.pmid: 18163209
references.citation: Eur J Epidemiol. 2010 Sep;25(9):603-5
references.pmid: 20652370
references.citation: J Clin Epidemiol. 2003 Apr;56(4):297-303
references.pmid: 12767405
references.citation: Stroke Res Treat. 2011;2011:792923
references.pmid: 21776367
references.citation: Cytokine. 2010 Dec;52(3):221-4
references.pmid: 21030268
references.citation: Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9465-70
references.pmid: 9689103
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: PLoS One. 2013 Sep 11;8(9):e74126
references.pmid: 24040186
references.citation: Atherosclerosis. 2008 May;198(1):166-73
references.pmid: 17981284
references.citation: Ann N Y Acad Sci. 2007 Apr;1100:189-98
references.pmid: 17460178
references.citation: Cytokine. 2012 Jun;58(3):398-405
references.pmid: 22425140
references.citation: Lancet Neurol. 2007 Feb;6(2):149-61
references.pmid: 17239802