title: Selenium partially prevents cisplatin-induced neurotoxicity: a preliminary study.
abstract: Cisplatin is an anticancer drug and it has neurotoxic effects. On the other hand, the neuroprotective effect of selenium was observed in previous studies. However, the effect of selenium on cisplatin-induced neurotoxicity has not been studied yet. Therefore, we aimed to investigate whether selenium prevent cisplatin-induced neurotoxicity. Twenty-one male Wistar albino rats were divided into three groups: control (C), cisplatin (CS), cisplatin and selenium (CSE, n=7 in each group). Cisplatin (12 mg/kg/day, i.p.) was administered for 3 days to CS and CSE groups. Also, CSE group received via oral gavage 3 mg/kg/day (twice-a-day as 1.5 mg/kg) selenium 5 days before of cisplatin injection and continued for 11 consecutive days. The same volumes of saline were intraperitoneally and orally administered to C group at same time. At the end of experimental protocol, electrophysiological and histopathological examinations were performed. The nerve conduction velocity, amplitude of compound action potential and number of axon of CS group were significantly lower than the C group. However, the same parameters of CSE group were significantly higher than the CS group. Although, cisplatin has a peripheral neurotoxic effect in rats, this effect was partially prevented by selenium treatment. Thus, it appears that co-administration of selenium and cisplatin may be a useful approach to decrease severity of peripheral neurotoxicity.
authors.affiliation: Balikesir University, Faculty of Medicine, Department of Physiology, Balikesir, Turkey. Electronic address: haerken@yahoo.com.
authors.forename: Haydar Ali
authors.initials: HA
authors.lastname: Erken
authors.affiliation: Balikesir University, Faculty of Medicine, Department of Neurology, Balikesir, Turkey.
authors.forename: Emine Rabia
authors.initials: ER
authors.lastname: Koç
authors.affiliation: Balikesir University, Faculty of Medicine, Department of Ear Nose Throat, Balikesir, Turkey.
authors.forename: Haşmet
authors.initials: H
authors.lastname: Yazıcı
authors.affiliation: Erciyes University, Faculty of Medicine, Department of Histology and Embryology, Kayseri, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Yay
authors.affiliation: Erciyes University, Faculty of Medicine, Department of Histology and Embryology, Kayseri, Turkey.
authors.forename: Gözde Özge
authors.initials: GÖ
authors.lastname: Önder
authors.affiliation: Hacettepe University, Faculty of Medicine, Department of Oncology, Ankara, Turkey.
authors.forename: Saim Furkan
authors.initials: SF
authors.lastname: Sarıcı
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001369:Axons / Q000187:drug effects; D002945:Cisplatin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D008297:Male; D009410:Nerve Degeneration; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010865:Pilot Projects; D051381:Rats; D012584:Sciatic Nerve / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D012643:Selenium / Q000494:pharmacology*; D014131:Trace Elements / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D018696:Neuroprotective Agents; D014131:Trace Elements; D012643:Selenium; D002945:Cisplatin
keywords: Cisplatin; Neuropathy; Neuroprotective effect; Neurotoxicity; Selenium