title: Cardiovascular risk stratification and management in pre-diabetes.
abstract: Prediabetes, covering individuals with impaired fasting glycemia, impaired glucose tolerance, or high-risk HbA1c levels, is associated with a ∼20 % increased risk of developing cardiovascular disease (CVD) compared with normoglycemic individuals. It is well-known that lifestyle or pharmacologic interventions can prevent diabetes in prediabetic people; however, the evidence is less clear regarding prevention of CVD. Most diabetes prevention trials have failed to show beneficial effects on CVD morbidity and mortality despite significant improvements of CVD risk factors in individuals with prediabetes. Another challenge is how to estimate CVD risk in prediabetic people. In general, prediction models for CVD do not take glucose levels or prediabetes status into account, thereby underestimating CVD risk in these high-risk individuals. More evidence within risk stratification and management of CVD risk in prediabetes is needed in order to recommend useful and effective strategies for early prevention of CVD.
authors.affiliation: Steno Diabetes Center A/S, Niels Steensens Vej 2, 2820, Gentofte, Denmark, krif@steno.dk.
authors.forename: Kristine
authors.initials: K
authors.lastname: Færch
authors.forename: Dorte
authors.initials: D
authors.lastname: Vistisen
authors.forename: Nanna Borup
authors.initials: NB
authors.lastname: Johansen
authors.forename: Marit Eika
authors.initials: ME
authors.lastname: Jørgensen
mesh_terms: D020909:Acarbose / Q000627:therapeutic use; D017677:Age Distribution; D001786:Blood Glucose / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control*; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D018149:Glucose Intolerance; D006442:Glycated Hemoglobin / Q000378:metabolism*; D065089:Glycoside Hydrolase Inhibitors / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011236:Prediabetic State / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors; D040242:Risk Reduction Behavior; D017678:Sex Distribution
chemical_list: D020909:Acarbose; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D065089:Glycoside Hydrolase Inhibitors; C517652:hemoglobin A1c protein, human
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