title: Sleep-wake misperception in sleep apnea patients undergoing diagnostic versus titration polysomnography.
abstract: OBJECTIVE
  Insomnia is commonly co-morbid with obstructive sleep apnea. Among patients reporting insomnia symptoms, sleep misperception occurs when self-reported sleep duration under-estimates objective measures. Misperception represents a clinical challenge since insomnia management is based entirely on patient self-report. We tested the hypothesis that misperception occurring in sleep apnea patients would improve with subsequent treatment.
  
  
  METHODS
  We compared subjective sleep-wake reports with objective sleep in adults with obstructive sleep apnea (n=405) in two nights of polysomnography (diagnostic and treatment) within a median interval of 92 days.
  
  
  RESULTS
  Sleep latency was generally over-estimated, while wake after sleep onset and number of awakenings were under-estimated. None of these estimations differed between diagnostic and treatment polysomnograms. We observed a large spectrum of total sleep time misperception values during the diagnostic polysomnogram, with one third of the cohort under-estimating their total sleep time by at least 60 min. Of those with >60 minute misperception, we observed improved total sleep time perception during treatment polysomnography. Improved perception correlated with improvements in self-reported sleep quality and response confidence. We found no polysomnogram or demographic predictors of total sleep time misperception for the diagnostic polysomnogram, nor did we find objective correlates of improved perception during titration.
  
  
  CONCLUSIONS
  Our results suggest that misperception may improve with treatment of obstructive sleep apnea in patients who also exhibit misperception. Within subject changes in misperception are consistent with misperception being, at least to some extent, a state characteristic, which has implications for management of patients with comorbid insomnia and sleep apnea.
authors.affiliation: Neurology Department, Sleep Division, Massachusetts General Hospital, Boston, MA, United States.
authors.forename: Jelina
authors.initials: J
authors.lastname: Castillo
authors.affiliation: Neurology Department, Sleep Division, Massachusetts General Hospital, Boston, MA, United States.
authors.forename: Balaji
authors.initials: B
authors.lastname: Goparaju
authors.affiliation: Neurology Department, Sleep Division, Massachusetts General Hospital, Boston, MA, United States; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States. Electronic address: mtbianchi@partners.org.
authors.forename: Matt T
authors.initials: MT
authors.lastname: Bianchi
mesh_terms: D000328:Adult; D015897:Comorbidity; D004056:Differential Threshold; D004192:Discrimination, Psychological; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D057566:Self Report; D012890:Sleep; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D016896:Treatment Outcome; D014851:Wakefulness
keywords: Paradoxical insomnia; Self-report; Subjective
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