title: The primary cilium: guardian of organ development and homeostasis.
abstract: The primary cilium is an antenna-like organelle that plays a vital role in organ generation and maintenance. It protrudes from the cell surface where it receives signals from the surrounding environment and relays them into the cell. These signals are then integrated to give the required outputs in terms of proliferation, differentiation, migration and polarization that ultimately lead to organ development and homeostasis. Defects in cilia function underlie a wide range of diverse but related human developmental or degenerative diseases. Collectively known as ciliopathies, these disorders present with varying severity and multiple organ involvement. The appreciation of the medical importance of the primary cilium has stimulated a huge effort into studies of the underlying cellular mechanisms. These in turn have revealed that ciliopathies result not only from defective assembly or organization of the primary cilium, but also from impaired ciliary signaling. This special edition of Organogenesis contains a set of review articles that highlight the role of the primary cilium in organ development and homeostasis, much of which has been learnt from studies of the associated human diseases. Here, we provide an introductory overview of our current understanding of the structure and function of the cilium, with a focus on the signaling pathways that are coordinated by primary cilia to ensure proper organ generation and maintenance.
authors.affiliation: Department of Biochemistry; University of Leicester; Leicester, UK.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Fry
authors.affiliation: Department of Biochemistry; University of Leicester; Leicester, UK.
authors.forename: Michelle J
authors.initials: MJ
authors.lastname: Leaper
authors.affiliation: Department of Biochemistry; University of Leicester; Leicester, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Bayliss
mesh_terms: D002923:Cilia / Q000378:metabolism*; D002925:Ciliary Motility Disorders / Q000473:pathology; D006706:Homeostasis; D006801:Humans; D023421:Models, Animal; D038081:Organogenesis; D015398:Signal Transduction
keywords: cilia; ciliopathies; primary cilium; signaling pathways; syndromic diseases
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