title: Spirulina maximaProtects Liver From Isoniazid and Rifampicin Drug Toxicity.
abstract: Hepatotoxicity associated with isoniazid and rifampicin is one of the major impediments in antituberculosis therapy. The present study explored the prophylactic and therapeutic efficacies ofSpirulina maximain isoniazid and rifampicin induced hepatic damage in a rat model. Hepatic damage induced in Wistar rats by isoniazid and rifampicin resulted in significant alterations in biomarkers of liver function, namely, bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, and oxidative stress markers such as superoxide dismutase, catalase, glutathione, and thiobarbituric acid reactive substances. Co-administration ofSpirulina maximaalong with antituberculosis drugs protected liver from hepatotoxicity due to isoniazid and rifampicin. Administration ofSpirulina maximaconsecutively for 2 weeks to hepatodamaged animals resulted in restoration of hepatic function as evident from normalization of serum markers of liver function. Thus, the present study revealed remarkable prophylactic and therapeutic potential ofSpirulina maxima. Co-administration ofSpirulina maximaand antituberculosis drugs is advantageous as it provides extra nutritional benefit.
authors.affiliation: 1 Jiwaji University, Gwalior, India.
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Jatav
authors.affiliation: 1 Jiwaji University, Gwalior, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Kulshrestha
authors.affiliation: 1 Jiwaji University, Gwalior, India.
authors.forename: Anish
authors.initials: A
authors.lastname: Zacharia
authors.affiliation: 1 Jiwaji University, Gwalior, India.
authors.forename: Nita
authors.initials: N
authors.lastname: Singh
authors.affiliation: 2 Boston College of Professional Studies, Gwalior, India.
authors.forename: G
authors.initials: G
authors.lastname: Tejovathi
authors.affiliation: 1 Jiwaji University, Gwalior, India.
authors.forename: P S
authors.initials: PS
authors.lastname: Bisen
authors.affiliation: 1 Jiwaji University, Gwalior, India.
authors.forename: G B K S
authors.initials: GBKS
authors.lastname: Prasad
keywords: hepatotoxicity; isoniazid; rifampicin; tuberculosis