title: Effects of paroxetine on cutaneous wound healing in healthy and diabetic rats.
abstract: OBJECTIVE
  The aim of this study was to evaluate the histologic effects of acute paroxetine administration on wound healing in healthy and streptozotocin-induced diabetic rats.
  
  
  METHODS
  This study has a randomized controlled experimental design.
  
  
  METHODS
  Healthy (n = 32) and diabetic (n = 32) rats were further divided into 2 groups of saline or paroxetine administration.
  
  
  METHODS
  Sixty-four male Sprague-Dawley rats were used in this study.
  
  
  METHODS
  Paroxetine was injected intraperitoneally every day. Full-thickness excision wounds were created with a 4-mm dermal punch on the back of all rats. The healing wound area was removed with a 6-mm dermal punch at postwounding days 1, 3, 7, and 14.
  
  
  METHODS
  Polymorphonuclear leukocyte, mononuclear inflammatory cell, fibroblast, and blood vessel counts and epithelialization were evaluated under light microscope.
  
  
  RESULTS
  There was no statistically significant difference observed in the polymorphonuclear leukocyte, mononuclear inflammatory cell, and blood vessel counts in the healthy and diabetic rats with and without paroxetine administration. The number of fibroblasts was significantly higher at postwounding day 14 of the paroxetine-administered healthy rats compared with the saline-administered healthy rats (P = .04). However, the number of fibroblasts did not show any difference by paroxetine administration in the diabetic rats. There was no statistically significant difference in epithelialization regarding all the postwounding days, but complete epithelialization was observed in all rats on postwounding day 14 in the healthy and paroxetine-administered group.
  
  
  CONCLUSIONS
  Short-term paroxetine administration may enhance cutaneous wound healing by increasing the number of fibroblasts and causing better epithelialization over time in healthy rats but not in diabetic rats.
authors.affiliation: Esra Pancar Yuksel, MD, is Assistant Professor of Dermatology at the Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samson, Turkey. Fatih Ilkaya, MD, is Assistant Professor of Pharmacology at the Department of Pharmacology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Levent Yildiz, MD, is Professor of Pathology at the Department of Pathology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Fatma Aydin, MD, and Nilgun Senturk, MD, are Professors of Dermatology at the Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Hilal Denizli, MD, is a Resident in Dermatology at the Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Tayyar Canturk, MD, and Ahmet Yasar Turanli, MD, are Professors of Dermatology at the Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Esra Pancar
authors.initials: EP
authors.lastname: Yuksel
authors.forename: Fatih
authors.initials: F
authors.lastname: Ilkaya
authors.forename: Levent
authors.initials: L
authors.lastname: Yildiz
authors.forename: Fatma
authors.initials: F
authors.lastname: Aydin
authors.forename: Nilgun
authors.initials: N
authors.lastname: Senturk
authors.forename: Hilal
authors.initials: H
authors.lastname: Denizli
authors.forename: Tayyar
authors.initials: T
authors.lastname: Canturk
authors.forename: Ahmet Yasar
authors.initials: AY
authors.lastname: Turanli
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005347:Fibroblasts / Q000502:physiology*; D007274:Injections, Intraperitoneal; D008297:Male; D009504:Neutrophils / Q000502:physiology; D017374:Paroxetine / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology; D014947:Wounds and Injuries / Q000473:pathology / Q000503:physiopathology
chemical_list: D017374:Paroxetine