title: Outcome of intracranial electroencephalography monitoring and surgery in magnetic resonance imaging-negative temporal lobe epilepsy.
abstract: We evaluated the outcomes of intracranial electroencephalography (iEEG) recording and subsequent resective surgery in patients with magnetic resonance imaging (MRI)-negative temporal lobe epilepsy (TLE). Thirty-two patients were identified from the Mayo Clinic Epilepsy Surgery Database (Arizona, Florida, and Minnesota). Eight (25.0%) had chronic iEEG monitoring that recorded neocortical temporal seizure onsets; 12 (37.5%) had mesial temporal seizure onsets; 5 (15.6%) had independent neocortical and mesial temporal seizure onsets; and 7 (21.9%) had simultaneous neocortical and mesial seizure onsets. Neocortical temporal lobe seizure semiology was the only factor significantly associated with neocortical temporal seizure onsets on iEEG. Only 33.3% of patients who underwent lateral temporal neocorticectomy had an Engel class 1 outcome, whereas 76.5% of patients with iEEG-guided anterior temporal lobectomy that included the amygdala and the hippocampus had an Engel class 1 outcome. Limitations in cohort size precluded statistical analysis of neuropsychological test data.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, United States.
authors.forename: Ricky W
authors.initials: RW
authors.lastname: Lee
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States.
authors.forename: Marietta M
authors.initials: MM
authors.lastname: Hoogs
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, United States.
authors.forename: David B
authors.initials: DB
authors.lastname: Burkholder
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States.
authors.forename: Max R
authors.initials: MR
authors.lastname: Trenerry
authors.affiliation: Department of Neurology, Mayo Clinic Hospital, Phoenix, AZ, United States.
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Drazkowski
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, FL, United States.
authors.forename: Jerry J
authors.initials: JJ
authors.lastname: Shih
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, FL, United States.
authors.forename: Karey E
authors.initials: KE
authors.lastname: Doll
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, FL, United States.
authors.forename: William O
authors.initials: WO
authors.lastname: Tatum
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, United States.
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Cascino
authors.affiliation: Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
authors.forename: W Richard
authors.initials: WR
authors.lastname: Marsh
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, United States.
authors.forename: Elaine C
authors.initials: EC
authors.lastname: Wirrell
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, United States; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Worrell
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, United States. Electronic address: eso@mayo.edu.
authors.forename: Elson L
authors.initials: EL
authors.lastname: So
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D015331:Cohort Studies; D016208:Databases, Factual; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures; D025321:Surgery, Computer-Assisted; D016896:Treatment Outcome; D055815:Young Adult
keywords: Epilepsy surgery; Intracranial electroencephalography; Normal magnetic resonance imaging; Temporal lobe epilepsy