title: How in vivo EPR measures and images oxygen.
abstract: The partial pressure of oxygen (pO₂) in tissues plays an important role in the pathophysiology of many diseases and influences outcome of cancer therapy, ischemic heart and cerebrovascular disease treatments and wound healing. Over the years a suite of EPR techniques for reliable oxygen measurements has been developed. This is a mini-review of pulse EPR in vivo oxygen imaging methods that utilize soluble spin probes. Recent developments in pulse EPR imaging technology have brought an order of magnitude increase in image acquisition speed, enhancement of sensitivity and considerable improvement in the precision and accuracy of oxygen measurements.
authors.affiliation: Center for EPR Imaging In Vivo Physiology, Chicago, IL, USA.|Department of Radiation Oncology, University of Chicago, Chicago, IL, USA.
authors.forename: Boris
authors.initials: B
authors.lastname: Epel
authors.affiliation: Center for EPR Imaging In Vivo Physiology, Chicago, IL, USA.|Department of Radiation Oncology, University of Chicago, Chicago, IL, USA.
authors.forename: Gage
authors.initials: G
authors.lastname: Redler
authors.affiliation: Center for EPR Imaging In Vivo Physiology, Chicago, IL, USA. h-halpern@uchicago.edu.|Department of Radiation Oncology, University of Chicago, Chicago, IL, USA. h-halpern@uchicago.edu.|MC1105, Department of Radiation and Cellular Oncology, University of Chicago Medical Center, 5841 S. Maryland Ave, Chicago, IL, 60637, USA. h-halpern@uchicago.edu.
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Halpern
mesh_terms: D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D010100:Oxygen / Q000032:analysis*; D015203:Reproducibility of Results
chemical_list: D010100:Oxygen
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