title: Cordyceps militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice.
abstract: To evaluate the immune activation and reactive oxygen species scavenging activity of Cordyceps militaris polysaccharides (CMP) in vivo, 90 male BALB/c mice were randomly divided into six groups. The mice in the three experimental groups were given cyclophosphamide at 80 mg/kg/d via intraperitoneal injection and 17.5, 35, or 70 mg/kg body weight CMP via gavage. The lymphocyte proliferation, phagocytic index, and biochemical parameters were measured. The results show that the administration of CMP was able to overcome the CY-induced immunosuppression, significantly increased the spleen and thymus indices, and enhanced the spleen lymphocyte activity and macrophage function. CMP can also improve the antioxidation activity in immunosuppressed mice, significantly increase the superoxidase dismutase, catalase, and glutathione peroxidase levels and the total antioxidant capacity, and decrease the malondialdehyde levels in vivo.
authors.affiliation: Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China; Department of Pharmacy, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, PR China.
authors.forename: Mi
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Pharmacy, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, PR China.
authors.forename: Xin Yu
authors.initials: XY
authors.lastname: Meng
authors.affiliation: Department of Pharmacy, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, PR China.
authors.forename: Rui Le
authors.initials: RL
authors.lastname: Yang
authors.affiliation: Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Qin
authors.affiliation: Department of Pharmacy, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, PR China.
authors.forename: Xiao Yang
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Department of Pharmacy, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, PR China.
authors.forename: Ke Yu
authors.initials: KY
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, PR China.
authors.forename: Chen Zhong
authors.initials: CZ
authors.lastname: Fei
authors.affiliation: Department of Pharmacy, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China.
authors.forename: Yuan liang
authors.initials: Yl
authors.lastname: Hu
authors.affiliation: Department of Pharmacy, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, PR China.
authors.forename: Fei Qun
authors.initials: FQ
authors.lastname: Xue
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D032661:Cordyceps; D003520:Cyclophosphamide / Q000494:pharmacology; D048690:Fruiting Bodies, Fungal; D062610:Fungal Polysaccharides / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D007155:Immunologic Factors / Q000494:pharmacology*; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D013154:Spleen / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects
chemical_list: D000975:Antioxidants; D062610:Fungal Polysaccharides; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D008315:Malondialdehyde; D003520:Cyclophosphamide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase