title: Cutting edge: NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus.
abstract: CMV induces the expansion of a unique subset of human NK cells expressing high levels of the activating CD94-NKG2C receptor that persist after control of the infection. We investigated whether this subset is CMV specific or is also responsive to acute infection with EBV. We describe a longitudinal study of CMV(-) and CMV(+) students who were acutely infected with EBV. The NKG2C(hi) NK subset was not expanded by EBV infection. However, EBV infection caused a decrease in the absolute number of immature CD56(bright)CD16(-) NK cells in the blood and, in CMV(+) individuals, induced an increased frequency of mature CD56(dim)NKG2A(+)CD57(+) NK cells in the blood that persisted into latency. These results provide further evidence that NKG2C(+) NK cells are CMV specific and suggest that EBV infection alters the repertoire of NK cells in the blood.
authors.affiliation: Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143;
authors.forename: Deborah W
authors.initials: DW
authors.lastname: Hendricks
authors.forename: Henry H
authors.initials: HH
authors.lastname: Balfour
authors.forename: Samantha K
authors.initials: SK
authors.lastname: Dunmire
authors.forename: David O
authors.initials: DO
authors.lastname: Schmeling
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Hogquist
authors.forename: Lewis L
authors.initials: LL
authors.lastname: Lanier
mesh_terms: D018959:CD57 Antigens / Q000276:immunology*; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000473:pathology; D020031:Epstein-Barr Virus Infections / Q000276:immunology* / Q000473:pathology; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D008137:Longitudinal Studies; D008297:Male; D055654:NK Cell Lectin-Like Receptor Subfamily C / Q000276:immunology*; D051920:NK Cell Lectin-Like Receptor Subfamily D / Q000276:immunology
chemical_list: D018959:CD57 Antigens; C527059:KLRC2 protein, human; C497869:KLRD1 protein, human; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D
references.citation: Eur J Immunol. 2012 Feb;42(2):447-57
references.pmid: 22105371
references.citation: Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8826-31
references.pmid: 12060703
references.citation: Nat Immunol. 2001 Oct;2(10):951-6
references.pmid: 11550009
references.citation: Blood. 2004 Dec 1;104(12):3664-71
references.pmid: 15304389
references.citation: Microbes Infect. 2002 Dec;4(15):1545-58
references.pmid: 12505527
references.citation: J Infect Dis. 2006 Jul 1;194(1):38-41
references.pmid: 16741880
references.citation: Blood. 2013 Apr 4;121(14):2678-88
references.pmid: 23325834
references.citation: J Immunol. 2012 Nov 15;189(10):5082-8
references.pmid: 23077239
references.citation: Blood. 2012 Mar 15;119(11):2665-74
references.pmid: 22180440
references.citation: Cell Rep. 2013 Dec 26;5(6):1489-98
references.pmid: 24360958
references.citation: Science. 2002 May 17;296(5571):1323-6
references.pmid: 11950999
references.citation: PLoS Pathog. 2008 Feb 8;4(2):e27
references.pmid: 18266470
references.citation: Clin Microbiol Rev. 2009 Jan;22(1):76-98, Table of Contents
references.pmid: 19136435
references.citation: J Infect Dis. 2013 Jan 1;207(1):80-8
references.pmid: 23100562
references.citation: Int Immunol. 2004 Jan;16(1):163-8
references.pmid: 14688071
references.citation: PLoS Pathog. 2011 Sep;7(9):e1002268
references.pmid: 21966274
references.citation: Am J Transplant. 2013 Feb;13 Suppl 3:9-23; quiz 23
references.pmid: 23347211
references.citation: Annu Rev Immunol. 2005;23:225-74
references.pmid: 15771571
references.citation: Immunol Rev. 2009 Jan;227(1):150-60
references.pmid: 19120482
references.citation: J Exp Med. 2011 Jan 17;208(1):13-21
references.pmid: 21173105
references.citation: Blood. 2010 Nov 11;116(19):3865-74
references.pmid: 20733159
references.citation: J Virol. 2013 Dec;87(24):13446-55
references.pmid: 24089567
references.citation: J Exp Med. 2012 Mar 12;209(3):471-8
references.pmid: 22393125
references.citation: Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14725-32
references.pmid: 21825173
references.citation: Br J Haematol. 2005 Apr;129(2):266-74
references.pmid: 15813855
references.citation: Clin Microbiol Rev. 2011 Jan;24(1):193-209
references.pmid: 21233512
references.citation: J Immunol. 2013 Nov 15;191(10):4989-95
references.pmid: 24108698