title: [Alternative splicing regulation: implications in cancer diagnosis and treatment].
abstract: The accurate expression of the genetic information is regulated by processes like mRNA splicing, proposed after the discoveries of Phil Sharp and Richard Roberts, who demonstrated the existence of intronic sequences, present in almost every structural eukaryotic gene, which should be precisely removed. This intron removal is called "splicing", which generates different proteins from a single mRNA, with different or even antagonistic functions. We currently know that alternative splicing is the most important source of protein diversity, given that 70% of the human genes undergo splicing and that mutations causing defects in this process could originate up to 50% of genetic diseases, including cancer. When these defects occur in genes involved in cell adhesion, proliferation and cell cycle regulation, there is an impact on cancer progression, rising the opportunity to diagnose and treat some types of cancer according to a particular splicing profile.
authors.affiliation: Laboratorio de Ecología Molecular Microbiana, Centro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, México.
authors.forename: Nancy
authors.initials: N
authors.lastname: Martínez-Montiel
authors.affiliation: Laboratorio de Bioquímica y Biología Molecular, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, México.
authors.forename: Nora
authors.initials: N
authors.lastname: Rosas-Murrieta
authors.affiliation: Laboratorio de Ecología Molecular Microbiana, Centro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, México. Electronic address: rebeca.martinez@correo.buap.mx.
authors.forename: Rebeca
authors.initials: R
authors.lastname: Martínez-Contreras
mesh_terms: D017398:Alternative Splicing; D014408:Biomarkers, Tumor / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D005819:Genetic Markers; D005820:Genetic Testing; D015316:Genetic Therapy; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers
keywords: Enfermedades genéticas; Genetic diseases; Ribonucleic acid; Spliceostatin; Spliceostatina; Ácido ribonucleico