title: Clinical safety, quality and effect of resin infiltration for proximal caries.
abstract: OBJECTIVE
  Resin infiltration of proximal lesions is a new approach to stop caries progression. The aim of this clinical trial was to assess its safety and quality, as well as the therapeutic effect.
  
  
  METHODS
  In 47 children, adolescents and young adults, ten dentists applied the infiltration material ICON (DMG, Germany) on initial proximal lesions according to the manufacturer's instruction. One lesion with radiographic extension into enamel or the outer third of dentin per participant was allocated for the treatment. The clinical safety and quality of resin infiltration were assessed 1 week, 6 months and 12 months after the treatment and the evaluation of the therapeutic effect was analysed by pair-wise radiographs.
  
  
  RESULTS
  The clinical safety and quality of the infiltration were assessed in 45 individuals after 12 months. The test surfaces showed no relevant changes in clinical status, plaque accumulation or gingival status (p > 0.05). A high quality of infiltration was found for the marginal adaptation. In contrast to the improvement of colour at the one-week recall (p = 0.005), the infiltrated surfaces showed a statistically significant increase in the discoloration within the following year (p = 0.014). Out of the 43 lesions which could be assessed radiographically, only two lesions showed progression to a different score (4.7%).
  
  
  CONCLUSIONS
  Resin infiltration can be considered a safe and effective treatment to reduce progression of initial proximal caries.
authors.affiliation: Department of Preventive and Pediatric Dentistry, University of Greifswald, Greifswald, Germany.
authors.forename: M B
authors.initials: MB
authors.lastname: Altarabulsi
authors.affiliation: Department of Preventive and Pediatric Dentistry, University of Greifswald, Greifswald, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Alkilzy
authors.affiliation: Department of Preventive and Pediatric Dentistry, University of Greifswald, Greifswald, Germany.
authors.forename: M A
authors.initials: MA
authors.lastname: Petrou
authors.affiliation: Department of Preventive and Pediatric Dentistry, University of Greifswald, Greifswald, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Splieth
mesh_terms: D000293:Adolescent; D000328:Adult; D002327:Cariostatic Agents / Q000592:standards / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003116:Color; D004245:DMF Index; D003731:Dental Caries / Q000000981:diagnostic imaging / Q000517:prevention & control*; D003743:Dental Enamel / Q000000981:diagnostic imaging / Q000187:drug effects; D018772:Dental Marginal Adaptation; D003774:Dental Plaque Index; D003791:Dental Pulp Test; D003804:Dentin / Q000000981:diagnostic imaging / Q000187:drug effects; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009910:Oral Hygiene; D010512:Periodontal Index; D010895:Pit and Fissure Sealants / Q000592:standards / Q000627:therapeutic use*; D016300:Radiography, Bitewing; D012117:Resins, Synthetic / Q000592:standards / Q000627:therapeutic use*; D012449:Safety; D013499:Surface Properties; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; D010895:Pit and Fissure Sealants; D012117:Resins, Synthetic; C578177:icon infiltrant