title: Differences in response to a dietary intervention between the general population and first-degree relatives of colorectal cancer patients.
abstract: OBJECTIVE
  To determine whether response to a dietary intervention is greater among people with family history of colorectal cancer (CRC) compared with a general population.
  
  
  METHODS
  Cohort study examining participants from 2 related studies.
  
  
  METHODS
  Rural Virginia.
  
  
  METHODS
  Seventy people with first-degree relatives with CRC and 113 participants from the intervention arm of a trial in the general population.
  
  
  METHODS
  Both studies implemented a low-intensity intervention delivered via telephone and mail, including low-literacy self-help booklets and personalized dietary feedback.
  
  
  METHODS
  Fat, fiber, and fruit and vegetable behavior.
  
  
  METHODS
  Propensity score matching controlled for confounders. Mixed-model ANOVAs compared samples; mediation by perceived cancer risk was assessed.
  
  
  RESULTS
  Participants in both groups significantly improved fat, fiber, and fruit and vegetable behavior at 1-month follow-up; there was significantly greater improvement in the general population sample. Cancer risk perception did not mediate the relationship between study sample and dietary change.
  
  
  CONCLUSIONS
  Contrary to expectations, first-degree relatives of CRC patients did not respond better to a dietary intervention than the general population, nor was risk perception related to dietary change. Given the role of diet in CRC risk, additional research should investigate targeted strategies to improve dietary intakes of people at higher cancer risk.
authors.affiliation: Department of Biostatistics and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA. Electronic address: mcclish@vcu.edu.
authors.forename: Donna
authors.initials: D
authors.lastname: McClish
authors.affiliation: Department of Health Administration, Virginia Commonwealth University, Richmond, VA.
authors.forename: Patrica
authors.initials: P
authors.lastname: Carcaise-Edinboro
authors.affiliation: Chiltern International, Wilmington, NC.
authors.forename: Hali
authors.initials: H
authors.lastname: Esinhart
authors.affiliation: Department of Internal Medicine and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA.
authors.forename: Diane Baer
authors.initials: DB
authors.lastname: Wilson
authors.affiliation: Department of Pediatrics, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, VA.
authors.forename: Melanie K
authors.initials: MK
authors.lastname: Bean
mesh_terms: D000704:Analysis of Variance; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D004032:Diet / Q000379:methods*; D005190:Family; D005260:Female; D006266:Health Education / Q000379:methods*; D007722:Health Knowledge, Attitudes, Practice; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012424:Rural Population; D014768:Virginia
keywords: colorectal cancer; diet intervention; family history
references.citation: Cancer Epidemiol Biomarkers Prev. 1997 May;6(5):355-61
references.pmid: 9149896
references.citation: Prev Med. 1995 Mar;24(2):166-70
references.pmid: 7597019
references.citation: Health Educ Behav. 2000 Apr;27(2):213-22
references.pmid: 10768802
references.citation: Prev Med. 1994 May;23(3):302-8
references.pmid: 8078850
references.citation: Am J Health Behav. 2008 Jul-Aug;32(4):347-55
references.pmid: 18092895
references.citation: Breast Cancer Res Treat. 1993 Nov;28(2):145-55
references.pmid: 8173067
references.citation: Health Psychol. 2011 Jul;30(4):481-91
references.pmid: 21744967
references.citation: Prev Med. 2005 May;40(5):489-501
references.pmid: 15749130
references.citation: Cancer Nurs. 2002 Aug;25(4):251-65
references.pmid: 12181494
references.citation: Eur J Cancer. 2006 Jan;42(2):216-27
references.pmid: 16338133
references.citation: Prev Med. 2004 Apr;38(4):388-402
references.pmid: 15020172
references.citation: Am J Prev Med. 2005 Feb;28(2):162-8
references.pmid: 15710271
references.citation: J Health Commun. 2013;18(4):397-409
references.pmid: 23272708
references.citation: J Natl Cancer Inst Monogr. 1999;(25):101-19
references.pmid: 10854465
references.citation: Health Psychol. 1988;7(4):355-86
references.pmid: 3049068
references.citation: Cancer Detect Prev. 2004;28(6):409-17
references.pmid: 15582264
references.citation: J Clin Epidemiol. 2006 May;59(5):437-47
references.pmid: 16632131
references.citation: Environ Health. 2009 Dec 21;8 Suppl 1:S1
references.pmid: 20102576
references.citation: Gastrointest Endosc. 2011 Mar;73(3):527-534.e2
references.pmid: 21353850
references.citation: Health Educ Q. 1988 Summer;15(2):175-83
references.pmid: 3378902
references.citation: J Am Diet Assoc. 1990 Feb;90(2):214-20
references.pmid: 2303658
references.citation: Fam Cancer. 2013 Dec;12(4):629-37
references.pmid: 23546820
references.citation: J Behav Med. 1997 Dec;20(6):607-19
references.pmid: 9429991
references.citation: Ann Behav Med. 2004 Apr;27(2):125-30
references.pmid: 15026296
references.citation: Prev Med. 2004 Aug;39(2):253-62
references.pmid: 15226033
references.citation: MMWR Morb Mortal Wkly Rep. 2011 Jul 8;60(26):884-9
references.pmid: 21734636
references.citation: Am J Public Health. 1997 Apr;87(4):610-6
references.pmid: 9146440
references.citation: J Cancer Epidemiol. 2011;2011:107497
references.pmid: 22496688
references.citation: Therap Adv Gastroenterol. 2008 Nov;1(3):157-67
references.pmid: 21180525
references.citation: Asian Pac J Cancer Prev. 2004 Oct-Dec;5(4):419-27
references.pmid: 15546249
references.citation: J Womens Health (Larchmt). 2011 Aug;20(8):1201-6
references.pmid: 21671767
references.citation: Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1296-302
references.pmid: 21737410
references.citation: Biom J. 2009 Feb;51(1):171-84
references.pmid: 19197955