title: Morning and evening oscillators cooperate to reset circadian behavior in response to light input.
abstract: Light is a crucial input for circadian clocks. In Drosophila, short light exposure can robustly shift the phase of circadian behavior. The model for this resetting posits that circadian photoreception is cell autonomous: CRYPTOCHROME senses light, binds to TIMELESS (TIM), and promotes its degradation, which is mediated by JETLAG (JET). However, it was recently proposed that interactions between circadian neurons are also required for phase resetting. We identify two groups of neurons critical for circadian photoreception: the morning (M) and the evening (E) oscillators. These neurons work synergistically to reset rhythmic behavior. JET promotes acute TIM degradation cell autonomously in M and E oscillators but also nonautonomously in E oscillators when expressed in M oscillators. Thus, upon light exposure, the M oscillators communicate with the E oscillators. Because the M oscillators drive circadian behavior, they must also receive inputs from the E oscillators. Hence, although photic TIM degradation is largely cell autonomous, neural cooperation between M and E oscillators is critical for circadian behavioral photoresponses.
authors.affiliation: Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA; Program in Neuroscience, Graduate School of Biomedical Sciences, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Lamba
authors.affiliation: Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Bilodeau-Wentworth
authors.affiliation: Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA; Program in Neuroscience, Graduate School of Biomedical Sciences, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA. Electronic address: patrick.emery@umassmed.edu.
authors.forename: Patrick
authors.initials: P
authors.lastname: Emery
authors.affiliation: Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA. Electronic address: yong.zhang@umassmed.edu.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D056931:Cryptochromes / Q000378:metabolism; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D044783:F-Box Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D008027:Light; D008969:Molecular Sequence Data; D016296:Mutagenesis; D009474:Neurons / Q000378:metabolism; D034622:RNA Interference; D016415:Sequence Alignment
chemical_list: D056931:Cryptochromes; D029721:Drosophila Proteins; D044783:F-Box Proteins; C511696:JET protein, Drosophila
references.citation: Nature. 2004 Oct 14;431(7010):862-8
references.pmid: 15483615
references.citation: J Comp Neurol. 2006 Jul 20;497(3):326-49
references.pmid: 16736474
references.citation: PLoS Biol. 2007 Nov;5(11):e315
references.pmid: 18044989
references.citation: Nat Neurosci. 2009 Nov;12(11):1431-7
references.pmid: 19820704
references.citation: Curr Biol. 2009 Feb 10;19(3):241-7
references.pmid: 19185492
references.citation: Cell. 1999 Dec 23;99(7):791-802
references.pmid: 10619432
references.citation: Genetics. 2007 Sep;177(1):329-45
references.pmid: 17720919
references.citation: Curr Biol. 2010 Apr 13;20(7):600-5
references.pmid: 20362449
references.citation: J Neurobiol. 2000 Jun 5;43(3):207-33
references.pmid: 10842235
references.citation: Neuron. 2010 May 13;66(3):378-85
references.pmid: 20471351
references.citation: Nature. 2000 Mar 30;404(6777):456-7
references.pmid: 10761904
references.citation: Nature. 2004 Oct 14;431(7010):869-73
references.pmid: 15483616
references.citation: Mol Cell Biol. 2001 Nov;21(21):7287-94
references.pmid: 11585911
references.citation: Nature. 2007 Jul 12;448(7150):151-6
references.pmid: 17625558
references.citation: Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17313-8
references.pmid: 17068124
references.citation: Cold Spring Harb Symp Quant Biol. 2007;72:527-41
references.pmid: 18419312
references.citation: Cell. 1998 Nov 25;95(5):681-92
references.pmid: 9845370
references.citation: J Comp Neurol. 2008 Jun 20;508(6):952-66
references.pmid: 18399544
references.citation: Neuron. 1998 Jul;21(1):225-34
references.pmid: 9697866
references.citation: Neuron. 1998 Jul;21(1):215-23
references.pmid: 9697865
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19587-94
references.pmid: 19060186
references.citation: Genetics. 2009 Mar;181(3):965-75
references.pmid: 19153257
references.citation: Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):516-21
references.pmid: 21187431
references.citation: Nucleic Acids Res. 1997 Feb 1;25(3):455-8
references.pmid: 9016581
references.citation: Curr Biol. 2008 Jan 22;18(2):R84-93
references.pmid: 18211849
references.citation: Nature. 2005 Nov 10;438(7065):238-42
references.pmid: 16281038
references.citation: Cell. 1998 Nov 25;95(5):669-79
references.pmid: 9845369
references.citation: Science. 2006 Jun 23;312(5781):1809-12
references.pmid: 16794082
references.citation: Science. 2004 Jun 4;304(5676):1503-6
references.pmid: 15178801
references.citation: Science. 2011 Mar 18;331(6023):1409-13
references.pmid: 21385718
references.citation: Neuron. 1994 Oct;13(4):967-74
references.pmid: 7946340
references.citation: Science. 2007 Jun 29;316(5833):1898-900
references.pmid: 17600216