title: Repurposing staples for viruses: applying peptide design to RSV prophylaxis.
abstract: Respiratory syncytial virus (RSV) is responsible for lower respiratory tract infections and annually results in 200,000 deaths worldwide. Despite the burden of RSV-associated disease, treatments and preventative measures are limited. In this issue of JCI, Bird and colleagues describe their work using a peptide stapling technique that allowed synthesis of a stable peptide mimic of a portion of the RSV fusion protein. Pretreatment of cells with the stable peptide effectively blocked virus entry. When introduced into mice prior to RSV exposure, the peptide produced a substantial prophylactic effect. This work provides a new way forward in RSV prevention.
authors.forename: Sarah P
authors.initials: SP
authors.lastname: Katen
authors.forename: Terence S
authors.initials: TS
authors.lastname: Dermody
mesh_terms: D000818:Animals; D005260:Female; D009668:Nose Diseases / Q000517:prevention & control*; D010455:Peptides; D011024:Pneumonia, Viral / Q000517:prevention & control*; D018357:Respiratory Syncytial Virus Infections / Q000517:prevention & control*; D012136:Respiratory Syncytial Viruses; D014760:Viral Fusion Proteins
chemical_list: D010455:Peptides; D014760:Viral Fusion Proteins
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