title: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue of the salivary glands: a population-based study from 1994 to 2009.
abstract: BACKGROUND
  Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) arising from the salivary glands is rare.
  
  
  METHODS
  Five hundred seven cases were available for frequency/incidence analysis, and 712 for relative survival and regression analysis in the Surveillance Epidemiology and End Results (SEER) database.
  
  
  RESULTS
  Of the total patients, 72.98% were women, 80.47% were white, and 74.75% were ≥50 years old. The parotid gland was involved in 80.87% of cases. Ann Arbor stage at diagnosis was 53.85% IE, 18.54% IIE, and 10.06% IIIE/IV. Overall, 15-year relative survival was 78.40%. Relative survival was worst among blacks and those with advanced-stage disease. No difference was noted between those treated with surgery, radiation, or both. Statistically significant poor prognosticators included black race (hazard ratio [HR], 2.3961; 95% confidence interval [CI], 1.54-3.72; p = .0001) and stage IIIE/IV (HR, 2.3677; 95%CI, 1.36-4.11; p = .0022).
  
  
  CONCLUSIONS
  Early-stage salivary gland MALT lymphoma disease may be amenable to unimodality treatment. Even patients with advanced disease have relatively high survivals.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Vazquez
authors.forename: Mohemmed N
authors.initials: MN
authors.lastname: Khan
authors.forename: Saurin
authors.initials: S
authors.lastname: Sanghvi
authors.forename: Neal R
authors.initials: NR
authors.lastname: Patel
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Caputo
authors.forename: Soly
authors.initials: S
authors.lastname: Baredes
authors.forename: Jean Anderson
authors.initials: JA
authors.lastname: Eloy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005006:Ethnicity / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000453:epidemiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018426:SEER Program; D012468:Salivary Gland Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D015996:Survival Rate; D044465:White People / Q000706:statistics & numerical data*; D055815:Young Adult
keywords: Surveillance Epidemiology and End Results (SEER); epidemiology; extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; major salivary glands; mucosa-associated lymphoid tissue (MALT) lymphoma; survival