title: AMD3100 protects from UV-induced skin cancer.
abstract: Sunlight causes skin cancer by directly damaging DNA as well as by suppressing antitumor immune responses. A major mechanism whereby sunlight exerts immunosuppressive effects is by modulating the migration of chemokine (C-X-C motif) receptor 4 (CXCR4)-expressing dermal mast cells into and away from the skin. We have demonstrated the importance of this by showing that the systemic administration of the CXCR4 antagonist AMD3100 prevents sunlight-induced immunosuppression as well as the consequent carcinogenic response. Our results highlight the therapeutic potential of antagonizing CXCR4 signaling, especially in individuals who are at high risk of developing skin cancer.
authors.affiliation: Cellular Photoimmunology Group; Discipline of Infectious Diseases and Immunology; Sydney Medical School; University of Sydney; Sydney, NSW Australia ; Department of Dermatology; Royal Prince Alfred Hospital; Camperdown, NSW Australia ; Discipline of Dermatology at The Bosch Institute; Sydney Medical School; University of Sydney; Sydney, NSW Australia.
authors.forename: Scott N
authors.initials: SN
authors.lastname: Byrne
authors.affiliation: Cellular Photoimmunology Group; Discipline of Infectious Diseases and Immunology; Sydney Medical School; University of Sydney; Sydney, NSW Australia ; Department of Dermatology; Royal Prince Alfred Hospital; Camperdown, NSW Australia ; Discipline of Dermatology at The Bosch Institute; Sydney Medical School; University of Sydney; Sydney, NSW Australia ; Faculty of Medicine and Health Sciences; Universiti Putra Malaysia; Malaysia.
authors.forename: Seri Ne
authors.initials: SN
authors.lastname: Sarchio
keywords: chemokines; immunosuppression; mast cells; skin cancer; sunlight; ultraviolet radiation
references.citation: J Invest Dermatol. 2012 Mar;132(3 Pt 2):896-905
references.pmid: 22170491
references.citation: J Invest Dermatol. 2014 Apr;134(4):1091-1100
references.pmid: 24226205
references.citation: Cancer Immunol Immunother. 2012 Oct;61(10):1713-20
references.pmid: 22399057
references.citation: J Dermatol Sci. 2012 Jun;66(3):176-82
references.pmid: 22277701
references.citation: J Immunol. 2008 Apr 1;180(7):4648-55
references.pmid: 18354188
references.citation: J Exp Med. 1998 Jun 15;187(12):2045-53
references.pmid: 9625764
references.citation: Cancer Res. 2011 Aug 15;71(16):5522-5534
references.pmid: 21742774
references.citation: J Invest Dermatol. 2012 May;132(5):1497-500
references.pmid: 22297641
references.citation: Nat Immunol. 2007 Oct;8(10):1095-104
references.pmid: 17767162
references.citation: Cancer Res. 2013 Jul 1;73(13):3927-37
references.pmid: 23633481