title: Agreement of retinal nerve fiber layer defect location between red-free fundus photography and cirrus HD-OCT maps.
abstract: OBJECTIVE
  To investigate the agreement of angular locations of retinal nerve fiber layer (RNFL) defect margins in glaucomatous eyes by using red-free fundus photographs and Cirrus high-definition optical coherence tomography (OCT) RNFL deviation and thickness maps.
  
  
  METHODS
  We examined 380 RNFL defects that showed clear margins in red-free fundus photographs. The OCT deviation and thickness maps were overlaid on the corresponding red-free fundus photographs. A reference line was drawn between the disc center and the macular center. Lines were also drawn between the optic disc center and the point where the RNFL defect margins crossed the OCT scan circle. The angle between the reference and defect-margin lines defined the angular location of the defect margin. Angular locations of proximal (nearest to the reference) and distal (farthest from the reference) RNFL defect margins on OCT deviation and thickness maps were compared to the locations on red-free fundus photographs.
  
  
  RESULTS
  The angular locations of proximal and distal RNFL defect margins on OCT thickness maps showed good agreement with red-free fundus photographs. However, OCT deviation maps showed greater angular locations for both proximal and distal RNFL defect margins compared with red-free fundus photographs, especially in eyes with higher myopia (p < 0.05).
  
  
  CONCLUSIONS
  Red-free fundus photographs and OCT thickness maps showed good agreement for the RNFL defect margin identification. However, this was not the case for deviation maps, especially in myopic eyes. This finding should be considered when evaluating RNFL defects using OCT maps.
authors.affiliation: Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute , Seoul , Korea and.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Hwang
authors.forename: Yong Yeon
authors.initials: YY
authors.lastname: Kim
authors.forename: Hwang Ki
authors.initials: HK
authors.lastname: Kim
authors.forename: Yong Ho
authors.initials: YH
authors.lastname: Sohn
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D015588:Observer Variation; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D010781:Photography / Q000379:methods*; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014065:Tonometry, Ocular; D055815:Young Adult
keywords: Fundus photography; glaucoma; optical coherence tomography; red-free photography; retinal nerve fiber layer