title: DEP domains: structurally similar but functionally different.
abstract: The Dishevelled, EGL-10 and pleckstrin (DEP) domain is a globular protein domain that is present in about ten human protein families with well-defined structural features. A picture is emerging that DEP domains mainly function in the spatial and temporal control of diverse signal transduction events by recruiting proteins to the plasma membrane. DEP domains can interact with various partners at the membrane, including phospholipids and membrane receptors, and their binding is subject to regulation.
authors.affiliation: Molecular Cancer Research and Cancer Genomics Netherlands, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, Utrecht, The Netherlands.
authors.forename: Sarah V
authors.initials: SV
authors.lastname: Consonni
authors.affiliation: Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
authors.forename: Madelon M
authors.initials: MM
authors.lastname: Maurice
authors.affiliation: Molecular Cancer Research and Cancer Genomics Netherlands, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, Utrecht, The Netherlands.
authors.forename: Johannes L
authors.initials: JL
authors.lastname: Bos
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D020662:Guanine Nucleotide Exchange Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D010750:Phosphoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D020710:RGS Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; D020662:Guanine Nucleotide Exchange Factors; C453280:PREX1 protein, human; D010750:Phosphoproteins; C116122:RAPGEF3 protein, human; D020710:RGS Proteins; C000606588:dsh protein, Drosophila
references.citation: Biochemistry. 2007 Jun 12;46(23):6859-70
references.pmid: 17511476
references.citation: J Biol Chem. 2005 Feb 11;280(6):4166-73
references.pmid: 15545267
references.citation: Biochim Biophys Acta. 1998 Jun 11;1385(1):157-64
references.pmid: 9630596
references.citation: Trends Pharmacol Sci. 2007 Oct;28(10):518-25
references.pmid: 17884187
references.citation: Trends Cell Biol. 2000 May;10(5):173-8
references.pmid: 10754559
references.citation: Mol Cell Biol. 2010 Nov;30(22):5421-31
references.pmid: 20855527
references.citation: Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
references.pmid: 12679517
references.citation: Cell. 2012 Jun 8;149(6):1192-205
references.pmid: 22682243
references.citation: Biochemistry. 2009 Mar 17;48(10):2282-9
references.pmid: 19182865
references.citation: Dev Biol. 1987 Feb;119(2):587-600
references.pmid: 3803719
references.citation: Curr Top Dev Biol. 2012;101:263-95
references.pmid: 23140633
references.citation: Trends Biochem Sci. 1996 Jul;21(7):245-6
references.pmid: 8755244
references.citation: Nat Cell Biol. 2009 Mar;11(3):286-94
references.pmid: 19234454
references.citation: Mol Cell. 2010 Dec 22;40(6):877-92
references.pmid: 21172654
references.citation: Cell. 2011 Oct 14;147(2):306-19
references.pmid: 22000011
references.citation: Clin Cancer Res. 2013 Sep 1;19(17):4564-9
references.pmid: 23753921
references.citation: Cell Res. 2004 Aug;14(4):324-30
references.pmid: 15353129
references.citation: G3 (Bethesda). 2013 Feb;3(2):251-62
references.pmid: 23390601
references.citation: Oncogene. 2009 Apr 23;28(16):1853-63
references.pmid: 19305425
references.citation: Mol Cell Biol. 2009 May;29(10):2521-31
references.pmid: 19273589
references.citation: Trends Genet. 2002 Nov;18(11):564-71
references.pmid: 12414186
references.citation: J Neurosci. 2003 Nov 12;23(32):10175-81
references.pmid: 14614075
references.citation: Dev Cell. 2007 Jan;12(1):129-41
references.pmid: 17199046
references.citation: Assay Drug Dev Technol. 2003 Apr;1(2):357-64
references.pmid: 15090201
references.citation: Nat Struct Mol Biol. 2008 Feb;15(2):155-62
references.pmid: 18204463
references.citation: Genomics. 2002 Feb;79(2):177-85
references.pmid: 11829488
references.citation: J Biol Chem. 2011 Jun 17;286(24):21806-13
references.pmid: 21511947
references.citation: Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):E812-20
references.pmid: 22411803
references.citation: J Biol Chem. 2006 Feb 3;281(5):2506-14
references.pmid: 16316996
references.citation: J Cell Sci. 1999 Dec;112 ( Pt 23):4175-83
references.pmid: 10564636
references.citation: Annu Rev Pharmacol Toxicol. 2010;50:355-75
references.pmid: 20055708
references.citation: Cell Biochem Biophys. 2009;54(1-3):33-46
references.pmid: 19521673
references.citation: Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3814-9
references.pmid: 22343288
references.citation: Genes Dev. 1998 Aug 15;12(16):2610-22
references.pmid: 9716412
references.citation: Cell. 2009 May 29;137(5):873-86
references.pmid: 19446321
references.citation: J Cell Sci. 2007 Jul 15;120(Pt 14):2402-12
references.pmid: 17606995
references.citation: Proteins. 2005 Feb 1;58(2):354-66
references.pmid: 15573383
references.citation: Cell Signal. 2008 Aug;20(8):1545-54
references.pmid: 18514484
references.citation: Science. 2013 Mar 22;339(6126):1441-5
references.pmid: 23371553
references.citation: J Cell Biol. 1997 Mar 10;136(5):1071-9
references.pmid: 9060471
references.citation: Nat Struct Mol Biol. 2007 Jun;14(6):484-92
references.pmid: 17529994
references.citation: J Biol Chem. 2011 May 20;286(20):17889-97
references.pmid: 21454623
references.citation: Trends Cell Biol. 2001 Dec;11(12):504-11
references.pmid: 11719057
references.citation: Biochem Biophys Res Commun. 2000 Oct 5;276(3):1162-9
references.pmid: 11027605
references.citation: Annu Rev Biochem. 2000;69:795-827
references.pmid: 10966476
references.citation: Nature. 1998 Dec 3;396(6710):474-7
references.pmid: 9853756
references.citation: J Biol Chem. 2006 Apr 28;281(17):11603-9
references.pmid: 16513654
references.citation: Nature. 2006 Feb 2;439(7076):625-8
references.pmid: 16452984
references.citation: Mol Cell. 2003 Nov;12(5):1251-60
references.pmid: 14636582
references.citation: Science. 2009 Nov 27;326(5957):1220-4
references.pmid: 19965465
references.citation: Cell. 2006 Sep 22;126(6):1079-93
references.pmid: 16990133
references.citation: Nat Struct Biol. 2000 Dec;7(12):1178-84
references.pmid: 11101902