title: [Patterns of liver metastasis and treatment outcomes of Chinese patients with hormonal receptor positive breast cancer].
abstract: OBJECTIVE
  To explore the clinical characteristics and prognosis of estrogen receptor/progesterone receptor (ER/PR) positive breast cancer (luminal subtype) patients with liver metastases.
  
  
  METHODS
  A total of 182 patients with liver metastasis from luminal subtype breast cancer between January 2000 and December 2011 were retrospectively reviewed. Their clinical characteristics, treatments and prognosis were collected and analyzed.
  
  
  RESULTS
  Their median age was 47 years and 118 patients were younger than 50 years old. The median disease-free survival (DFS) after primary operation of breast cancer was 19.5 months. All patients received first-line chemotherapy for liver metastases. Overall response (CR+PR) rate was 60.4% (110/182) . Progression-free survival (PFS) and overall survival (OS) were 8 and 23 months respectively. The median OS was extended by 7 months in younger patients ( ≤ 50) than in older ones (>50) (P < 0.05). In addition, PFS and OS were also extended by 3 and 7 months in patients with complete and partial responses than those who had stable and progressive diseases (P < 0.05). No difference existed in PFS and OS with or without capecitabine-based regimens(both P > 0.05).
  
  
  CONCLUSIONS
  Age and response to treatment are independent prognostic factors for ER and/or PR positive breast cancer patients with liver metastasis.
authors.affiliation: Department of Internal Medicine, Cancer Hospital & Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yue
authors.affiliation: Department of Internal Medicine, Cancer Hospital & Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Ma
authors.affiliation: Department of Internal Medicine, Cancer Hospital & Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Lingxiao
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Internal Medicine, Cancer Hospital & Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Internal Medicine, Cancer Hospital & Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Internal Medicine, Cancer Hospital & Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Internal Medicine, Cancer Hospital & Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Pin
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Internal Medicine, Cancer Hospital & Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China. Email: xubinghe@medmail.com.cn.
authors.forename: Binghe
authors.initials: B
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone