title: Functional assessment of the mouse heart by MRI with a 1-min acquisition.
abstract: In vivo assessment of heart function in mice is important for basic and translational research in cardiology. MRI is an accurate tool for the investigation of the anatomy and function in the preclinical setting; however, the long scan duration limits its usage. We aimed to reduce the acquisition time of cine MRI to 1 min. We employed spatiotemporal compressed sensing and parallel imaging to accelerate retrospectively gated cine MRI. We compared the functional parameters derived from full and undersampled data in Cartesian and radial MRI by means of Bland-Altman plots. We found that the scan time for the whole heart could be reduced to 2 min with Cartesian sampling and to 1 min with radial sampling. Despite a reduction in the signal-to-noise ratio, the accuracy in the estimation of left and right ventricular volumes was preserved for all tested subjects. This method can be used to perform accurate functional MRI examinations in mice for high-throughput phenotyping or translational studies.
authors.affiliation: Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: Guido
authors.initials: G
authors.lastname: Buonincontri
authors.forename: Carmen
authors.initials: C
authors.lastname: Methner
authors.forename: Thomas
authors.initials: T
authors.lastname: Krieg
authors.forename: T Adrian
authors.initials: TA
authors.lastname: Carpenter
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Sawiak
mesh_terms: D000818:Animals; D006321:Heart / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D025341:Principal Component Analysis; D059629:Signal-To-Noise Ratio
keywords: MRI; cine; compressed sensing; function; heart; mouse; parallel imaging; right ventricle