title: Resident progenitors, not exogenous migratory cells, generate the majority of visceral mesothelium in organogenesis.
abstract: Historically, analyses of mesothelial differentiation have focused on the heart where a highly migratory population of progenitors originating from a localized "extrinsic" source moves to and over the developing organ. This model long stood alone as the paradigm for generation of this cell type. Here, using chick/quail chimeric grafting and subsequent identification of mesothelial cell populations, we demonstrate that a different mechanism for the generation of mesothelia exists in vertebrate organogenesis. In this newly discovered model, mesothelial progenitors are intrinsic to organs of the developing digestive and respiratory systems. Additionally, we demonstrate that the early heart stands alone in its ability to recruit an entirely exogenous mesothelial cell layer during development. Thus, the newly identified "organ intrinsic" model of mesotheliogenesis appears to predominate while the long-studied cardiac model of mesothelial development may be the outlier.
authors.affiliation: Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
authors.forename: Nichelle I
authors.initials: NI
authors.lastname: Winters
authors.affiliation: Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
authors.forename: Annabelle M
authors.initials: AM
authors.lastname: Williams
authors.affiliation: Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: david.bader@vanderbilt.edu.
authors.forename: David M
authors.initials: DM
authors.lastname: Bader
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D002642:Chick Embryo; D002678:Chimera; D053595:Embryonic Stem Cells / Q000378:metabolism*; D004848:Epithelium / Q000196:embryology*; D041981:Gastrointestinal Tract / Q000196:embryology*; D006321:Heart / Q000196:embryology; D038081:Organogenesis; D011784:Quail; D012137:Respiratory System / Q000196:embryology*
keywords: Mesothelia; Organogenesis; coelomate
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