title: Reproducibility of urinary bisphenol A concentrations measured during pregnancy in the Generation R Study.
abstract: The potential human health effects of bisphenol A (BPA) exposure are a public health concern. In order to design adequately powered epidemiological studies to address potential health effects, data on the reproducibility of BPA concentration in serial urine specimens taken during pregnancy are needed. To provide additional data on the reproducibility of maternal urine specimens, 80 women in the Generation R Study (Rotterdam, The Netherlands) contributed a spot urine specimen at <18, 18-25, and >25 weeks of pregnancy. Reproducibility, estimated by the intraclass correlation coefficient (ICC), was 0.32 (95% confidence interval: 0.18-0.46), and, on a creatinine basis, 0.31 (95% confidence interval: 0.16-0.47). Although the ICC observed in the Generation R Study is slightly higher than previous reproducibility studies of BPA, it nevertheless indicates a high degree of within-person variability that presents challenges for designing well-powered epidemiologic studies.
authors.affiliation: Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Boulevard, Rochester, New York, USA.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Jusko
authors.affiliation: Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, 423 Guardian Drive, Philadelphia, Pennsylvania, USA.
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Shaw
authors.affiliation: 1] Department of Public Health, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands [2] The Generation R Study Group, Erasmus Medical Center, Erasmus Medical Centre, 3000 CA, Rotterdam, The Netherlands.
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Snijder
authors.affiliation: Department of Urban Environment and Safety, TNO (Netherlands Organization for Applied Scientific Research), Princetonlaan 6, 3584 CB, Utrecht, The Netherlands.
authors.forename: Frank H
authors.initials: FH
authors.lastname: Pierik
authors.affiliation: Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany.
authors.forename: Holger M
authors.initials: HM
authors.lastname: Koch
authors.affiliation: Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts, USA.
authors.forename: Russ
authors.initials: R
authors.lastname: Hauser
authors.affiliation: 1] The Generation R Study Group, Erasmus Medical Center, Erasmus Medical Centre, 3000 CA, Rotterdam, The Netherlands [2] Department of Epidemiology, Erasmus Medical Center, 3000 DR, Rotterdam, The Netherlands [3] Department of Pediatrics, Erasmus Medical Center, 3000 CB Rotterdam, The Netherlands.
authors.forename: Vincent W V
authors.initials: VW
authors.lastname: Jaddoe
authors.affiliation: Department of Public Health, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
authors.forename: Alex
authors.initials: A
authors.lastname: Burdorf
authors.affiliation: Department of Epidemiology, Erasmus Medical Center, 3000 DR, Rotterdam, The Netherlands.
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.affiliation: Department of Child and Adolescent Psychiatry, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
authors.forename: Henning
authors.initials: H
authors.lastname: Tiemeier
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, 111 T.W. Alexander Drive, Research Triangle Park, North Carolina, USA.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Longnecker
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000652:urine*; D052244:Endocrine Disruptors / Q000652:urine*; D005260:Female; D006801:Humans; D009426:Netherlands; D010636:Phenols / Q000652:urine*; D011247:Pregnancy; D015203:Reproducibility of Results; D055815:Young Adult; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
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