title: Chemical constituents from the fruits of Forsythia suspensa and their antimicrobial activity.
abstract: Lignans and phenylethanoid glycosides purified from Forsythia suspensa were reported to display various bioactivities in the previous literature, including the antimicrobial activity. Therefore, the present research is aimed to purify and identify the chemical constituents of the methanol extracts of fruits of F. suspensa. The methanol extracts of fruits of F. suspensa were fractionated and further purified with the assistance of column chromatography to afford totally thirty-four compounds. Among these isolates, 3 β -acetoxy-20 α -hydroxyursan-28-oic acid (1) was reported from the natural sources for the first time. Some of the purified principles were subjected to the antimicrobial activity examinations against Escherichia coli to explore new natural lead compounds.
authors.affiliation: Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan.
authors.forename: Ping-Chung
authors.identifier: 0000-0001-6675-1235
authors.initials: PC
authors.lastname: Kuo
authors.affiliation: Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan ; Department of Chemistry, National Chung-Hsing University, Taichung 402, Taiwan.
authors.forename: Guo-Feng
authors.initials: GF
authors.lastname: Chen
authors.affiliation: Department of Chemistry, National Chung-Hsing University, Taichung 402, Taiwan.
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Yang
authors.affiliation: Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan.
authors.forename: Ya-Hua
authors.initials: YH
authors.lastname: Lin
authors.affiliation: Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan.
authors.forename: Chi-Chung
authors.initials: CC
authors.lastname: Peng
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004926:Escherichia coli / Q000187:drug effects* / Q000502:physiology; D031657:Forsythia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D014315:Triterpenes
references.citation: Biosci Biotechnol Biochem. 2003 Mar;67(3):631-4
references.pmid: 12723615
references.citation: Bioorg Med Chem. 2005 Feb 1;13(3):627-30
references.pmid: 15653330
references.citation: Zhong Yao Tong Bao. 1988 Jul;13(7):32-4, 62-3
references.pmid: 3197218
references.citation: Appl Environ Microbiol. 2008 Oct;74(20):6230-8
references.pmid: 18723643
references.citation: J Pharm Pharmacol. 2008 Feb;60(2):261-6
references.pmid: 18237475
references.citation: Chem Pharm Bull (Tokyo). 1982 Dec;30(12):4548-53
references.pmid: 7168874
references.citation: Int J Food Microbiol. 2007 Jun 10;117(1):112-9
references.pmid: 17449125
references.citation: J Food Prot. 2002 Oct;65(10):1545-60
references.pmid: 12380738
references.citation: Phytochemistry. 2001 Apr;56(8):815-8
references.pmid: 11324910
references.citation: J Food Sci. 2011 Aug;76(6):M427-32
references.pmid: 21729076
references.citation: Appl Environ Microbiol. 2006 Feb;72(2):1135-40
references.pmid: 16461659
references.citation: Int J Food Microbiol. 2004 Aug 1;94(3):223-53
references.pmid: 15246235
references.citation: Food Microbiol. 2007 Oct-Dec;24(7-8):759-66
references.pmid: 17613374
references.citation: Am J Chin Med. 2006;34(3):511-22
references.pmid: 16710900
references.citation: Yao Xue Xue Bao. 1960 Jun;8:241-4
references.pmid: 13787554
references.citation: Chemistry. 2010 Mar 1;16(9):2751-7
references.pmid: 20082396
references.citation: Chem Pharm Bull (Tokyo). 1992 Feb;40(2):401-5
references.pmid: 1606636
references.citation: Yakugaku Zasshi. 1987 Apr;107(4):274-8
references.pmid: 3656088
references.citation: Molecules. 2009 Feb 19;14(2):850-67
references.pmid: 19255544
references.citation: J Agric Food Chem. 2007 Jan 10;55(1):75-9
references.pmid: 17199316
references.citation: Chem Pharm Bull (Tokyo). 2005 May;53(5):541-6
references.pmid: 15863927
references.citation: Phytochemistry. 1995 Dec;40(6):1691-5
references.pmid: 8590637
references.citation: Bioorg Chem. 2012 Feb;40(1):87-91
references.pmid: 22014602