title: Ocular malignant tumors. Review of the Tumor Registry at a tertiary eye hospital in central Saudi Arabia.
abstract: OBJECTIVE
  To present the epidemiologic profile and magnitude of ocular malignant tumors (MT) representative of the Saudi population from the Tumor Registry (TR) at King Khaled Eye Specialist Hospital (KKESH).
  
  
  METHODS
  This study evaluated the demographic information, clinical features including tumor laterality, ocular tissue of origin, and diagnosis of patients from the TR registry between 1983 and 2012 at KKESH, Riyadh, Kingdom of Saudi Arabia. The incidence of MT among Saudi adults (>/= 15 years old), and children (<15 years old) was estimated.
  
  
  RESULTS
  The TR recorded 4,146 neoplasms (2,509 [60.5%] benign tumors, and 1,637 [39.5%] MT). The incidence of MT in children was 3.6 per million/year (M/Y), and 2.4/M/Y for adults. Retinoblastoma (Rb) (n=763, 91%) was the most common ocular malignancy in children. In adults, the most common MT was squamous cell carcinoma (SCC) (n=363, 45.8%), basal cell carcinoma (BCC) (n=186, 23%), uvealmelanoma (n=94, 11.9%), sebaceous gland carcinoma (n=54, 6.8%), lymphomas (orbital, adnexal) (n=46, 5.8%), and others (n=53, 6.8%). The Rb (7.7/M/Y in <5 years old Saudi children) was less frequent than that reported in some Gulf countries, but higher than that reported from the West. The SCC was less frequent in countries with comparable sun exposure than in other continents, but the incidence remained unchanged over 3 decades. There was a significant increase in BCC between 1983-1992 and 2003-2012.
  
  
  CONCLUSIONS
  The rates of all cancers remained stable over 3 decades except BCC, which showed a significant rise.
authors.affiliation: Department of Research, Ophthalmic Epidemiology and Low Vision Services, King Khaled Eye Specialist Hospital, PO Box 7191, Riyadh 11462, Kingdom of Saudi Arabia. Tel. +966 (11) 4821234 Ext. 1362. Fax. +966 (11) 4829311. E-mail: rkhandekar@KKESH.med.sa.
authors.forename: Rajiv B
authors.initials: RB
authors.lastname: Khandekar
authors.forename: Abdulelah A
authors.initials: AA
authors.lastname: Al-Towerki
authors.forename: Hind
authors.initials: H
authors.lastname: Al-Katan
authors.forename: Saleh S
authors.initials: SS
authors.lastname: Al-Mesfer
authors.forename: Emad B
authors.initials: EB
authors.lastname: Abboud
authors.forename: Hailah M
authors.initials: HM
authors.lastname: Al-Hussain
authors.forename: Osama H
authors.initials: OH
authors.lastname: Sheikh
authors.forename: Imtiaz A
authors.initials: IA
authors.lastname: Chaudhry
authors.forename: Wafa A
authors.initials: WA
authors.lastname: Ahmed
authors.forename: Babar M
authors.initials: BM
authors.lastname: Zaman
authors.forename: Nasira
authors.initials: N
authors.lastname: Asghar
authors.forename: Deepak P
authors.initials: DP
authors.lastname: Edward
mesh_terms: D000293:Adolescent; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D012042:Registries; D012175:Retinoblastoma / Q000453:epidemiology; D012529:Saudi Arabia / Q000453:epidemiology; D055815:Young Adult