title: Activation of toll-like receptors and inflammasome complexes in the diabetic cardiomyopathy-associated inflammation.
abstract: Diabetic cardiomyopathy is defined as a ventricular dysfunction initiated by alterations in cardiac energy substrates in the absence of coronary artery disease and hypertension. Hyperglycemia, hyperlipidemia, and insulin resistance are major inducers of the chronic low-grade inflammatory state that characterizes the diabetic heart. Cardiac Toll-like receptors and inflammasome complexes may be key inducers for inflammation probably through NF-κB activation and ROS overproduction. However, metabolic dysregulated factors such as peroxisome proliferator-activated receptors and sirtuins may serve as therapeutic targets to control this response by mitigating both Toll-like receptors and inflammasome signaling.
authors.affiliation: Cardiovascular Research Laboratory, IIS-Fundación Jiménez Díaz, Autónoma University, Avenida Reyes Católicos 2, 28040 Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Fuentes-Antrás
authors.affiliation: Cardiovascular Research Laboratory, IIS-Fundación Jiménez Díaz, Autónoma University, Avenida Reyes Católicos 2, 28040 Madrid, Spain.
authors.forename: A M
authors.initials: AM
authors.lastname: Ioan
authors.affiliation: Cardiovascular Research Laboratory, IIS-Fundación Jiménez Díaz, Autónoma University, Avenida Reyes Católicos 2, 28040 Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Tuñón
authors.affiliation: Cardiovascular Research Laboratory, IIS-Fundación Jiménez Díaz, Autónoma University, Avenida Reyes Católicos 2, 28040 Madrid, Spain ; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM) Network, Avenida Reyes Católicos 2, 28040 Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Egido
authors.affiliation: Cardiovascular Research Laboratory, IIS-Fundación Jiménez Díaz, Autónoma University, Avenida Reyes Católicos 2, 28040 Madrid, Spain ; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM) Network, Avenida Reyes Católicos 2, 28040 Madrid, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Lorenzo
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