title: [Effect of diabetes on the relation between troponin T and inflammatory markers in patients on hemodialysis].
abstract: BACKGROUND
  Cardiac troponin T in renal failure is used for the assessment of cardiovascular risk and mortality. Elevated cardiac troponin T levels correlate with subclinical myocardial necrosis, coronary heart disease, several echocardiographic parameters, metastatic calcification, as well as the presence of diabetes and uremic toxins.
  
  
  OBJECTIVE
  The aim of the authors was to examine the impact of factors, mainly the independent effects of inflammatory laboratory parameters, which may influence hypersensitive troponin T levels in hemodialysed patient groups with and without diabetes.
  
  
  METHODS
  Hemodialysed patient groups with (n = 44) and without diabetes (n = 76) were studied. Difference in serum hypersensitive troponin T values before and after dialysis were analysed by paired Wilcoxon test. Factors possibly affecting the level of hypersensitive troponin T (especially inflammatory markers) were evaluated by multiregression analysis.
  
  
  RESULTS
  Hypersensitive troponin T levels in patients without diabetes (p = 0.0003) and those with diabetes (p = 0.0032) significantly increased during hemodialysis. In patients without diabetes several factors had significant effect on hypersensitive troponin T including age (p = 0.025), duration of hemodialysis (p = 0.0002), presence of cardiovascular complications (p = 0.0002), high sensitivity C-reactive protein (p = 0.0021), white blood cell count (p = 0.038), and the monocyte ratio (p = 0.0202). However, in patients with diabetes only high sensitivity C-reactive protein (p = 0.0024) showed association with hypersensitive troponin T levels.
  
  
  CONCLUSIONS
  In hemodyalised patients with and without diabetes the hypersensitive troponin T levels are differently influenced by clinical and inflammatory laboratory parameters, which should be taken into consideration during clinical judgement.
authors.affiliation: Csolnoky Ferenc Oktatókórház Veszprém Kórház u. 1. 8200 BBRAUN 3 Dialíziscentrum Veszprém.
authors.forename: Emília
authors.initials: E
authors.lastname: Mácsai
authors.affiliation: Csolnoky Ferenc Oktatókórház Veszprém Kórház u. 1. 8200.
authors.forename: Ilona
authors.initials: I
authors.lastname: Németh
authors.affiliation: BBRAUN 3 Dialíziscentrum Veszprém.
authors.forename: Attila
authors.initials: A
authors.lastname: Benke
authors.affiliation: Csolnoky Ferenc Oktatókórház Veszprém Kórház u. 1. 8200.
authors.forename: Gyula
authors.initials: G
authors.lastname: Dávid
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D048909:Diabetes Complications / Q000097:blood / Q000628:therapy; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T; D002097:C-Reactive Protein
keywords: diabetes mellitus; hemodialysis; hemodialízis; inflammatio; inflammation; troponin T