title: In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system.
abstract: The efficacy of two nanocarriers polyethylene glycol and polyvinyl alcohol magnetic nanoparticles coated with gallic acid (GA) was accomplished via X-ray diffraction, infrared spectroscopy, magnetic measurements, thermal analysis, and TEM. X-ray diffraction and TEM results showed that Fe3O4 nanoparticles were pure iron oxide having spherical shape with the average diameter of 9 nm, compared with 31 nm and 35 nm after coating with polyethylene glycol-GA (FPEGG) and polyvinyl alcohol-GA (FPVAG), respectively. Thermogravimetric analyses proved that after coating the thermal stability was markedly enhanced. Magnetic measurements and Fourier transform infrared (FTIR) revealed that superparamagnetic iron oxide nanoparticles could be successfully coated with two polymers (PEG and PVA) and gallic acid as an active drug. Release behavior of gallic acid from two nanocomposites showed that FPEGG and FPVAG nanocomposites were found to be sustained and governed by pseudo-second-order kinetics. Anticancer activity of the two nanocomposites shows that the FPEGG demonstrated higher anticancer effect on the breast cancer cell lines in almost all concentrations tested compared to FPVAG.
authors.affiliation: Materials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400, Selangor, Malaysia.
authors.forename: Dena
authors.identifier: 0000-0001-5414-9204
authors.initials: D
authors.lastname: Dorniani
authors.affiliation: Vaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400, Selangor, Malaysia.
authors.forename: Aminu Umar
authors.initials: AU
authors.lastname: Kura
authors.affiliation: Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400, Selangor, Malaysia.
authors.forename: Samer Hasan
authors.initials: SH
authors.lastname: Hussein-Al-Ali
authors.affiliation: Materials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400, Selangor, Malaysia.
authors.forename: Mohd Zobir
authors.initials: MZ
authors.lastname: Bin Hussein
authors.affiliation: Vaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400, Selangor, Malaysia.
authors.forename: Sharida
authors.initials: S
authors.lastname: Fakurazi
authors.affiliation: Physics Department, Faculty of Science, Universiti Putra Malaysia, 43400, Selangor, Malaysia.
authors.forename: Abdul Halim
authors.initials: AH
authors.lastname: Shaari
authors.affiliation: Vaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400, Selangor, Malaysia ; Chemical Pathology Unit, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Selangor, Malaysia.
authors.forename: Zalinah
authors.initials: Z
authors.lastname: Ahmad
mesh_terms: D000327:Adsorption; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000633:toxicity; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000633:toxicity; D004058:Diffusion; D005707:Gallic Acid / Q000032:analysis / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D066298:In Vitro Techniques; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity; D008422:Materials Testing; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000633:toxicity; D011142:Polyvinyl Alcohol / Q000737:chemistry* / Q000633:toxicity
chemical_list: D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D011092:Polyethylene Glycols; D005707:Gallic Acid; D011142:Polyvinyl Alcohol
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