title: Hybrid PET/MR imaging in two sarcoma patients - clinical benefits and implications for future trials.
abstract: PET/MRI is an evolving hybrid imaging modality which combines the inherent strengths of MRIs soft-tissue and contrast resolution and PETs functional metabolic capabilities. Bone and soft-tissue sarcoma are a relatively rare tumor entity, relying on MRI for local staging and often on PET/CT for lymph node involvement and metastatic spread evaluation. The purpose of this article is to demonstrate the successful use of PET/MRI in two sarcoma patients. We also use these patients as a starting point to discuss how PET/MRI might be of value in sarcoma. Among its potential benefits are: superior TNM staging than either modality alone, decreased radiation dose, more sensitive and specific follow-up and better assessment of treatment response. These potentials need to be investigated in future PET/MRI soft-tissue sarcoma trials.
authors.affiliation: Department of Radiology, University Hospitals Seidman Cancer Center, University Hospitals Case Medical Center, Case Western Reserve University Cleveland, Ohio.
authors.forename: Sasan
authors.initials: S
authors.lastname: Partovi
authors.affiliation: Department of Radiology, University Hospitals Seidman Cancer Center, University Hospitals Case Medical Center, Case Western Reserve University Cleveland, Ohio.
authors.forename: Andres A
authors.initials: AA
authors.lastname: Kohan
authors.affiliation: Department of Pediatrics, Rainbow Babies and Children's Hospital, University Hospitals Case Medical Center Cleveland, Ohio.
authors.forename: Lisa
authors.initials: L
authors.lastname: Zipp
authors.affiliation: Department of Radiology, University Hospitals Seidman Cancer Center, University Hospitals Case Medical Center, Case Western Reserve University Cleveland, Ohio.
authors.forename: Peter
authors.initials: P
authors.lastname: Faulhaber
authors.affiliation: Department of Radiology, University Hospitals Seidman Cancer Center, University Hospitals Case Medical Center, Case Western Reserve University Cleveland, Ohio.
authors.forename: Christos
authors.initials: C
authors.lastname: Kosmas
authors.affiliation: Department of Radiology, University Hospitals Seidman Cancer Center, University Hospitals Case Medical Center, Case Western Reserve University Cleveland, Ohio.
authors.forename: Pablo R
authors.initials: PR
authors.lastname: Ros
authors.affiliation: Department of Radiology, University Hospitals Seidman Cancer Center, University Hospitals Case Medical Center, Case Western Reserve University Cleveland, Ohio.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Robbin
keywords: FDG; PET/CT; PET/MRI; molecular hybrid imaging; sarcoma
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