title: Cytokine regulation during epidermal differentiation and barrier formation.
abstract: The role of structural components and cell adhesion molecules in the epidermis has not been fully studied in terms of the pathophysiology of atopic dermatitis (AD). In this issue, Omori-Miyake et al. (2014) report that IL-4 and IL-13, which are Th2 cytokines, downregulate the expression of keratins and desmosomal cadherins in a STAT6-dependent manner, leading to keratinocyte fragility in the face of mechanical stress. Th2 cytokine-induced instability of the epidermis may be considered to be one of the pathogenic mechanisms that have roles in AD.
authors.affiliation: Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan.
authors.forename: Atsunari
authors.initials: A
authors.lastname: Tsuchisaka
authors.affiliation: Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan.
authors.forename: Minao
authors.initials: M
authors.lastname: Furumura
authors.affiliation: Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan. Electronic address: hashimot@med.kurume-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
mesh_terms: D000818:Animals; D006801:Humans; D018793:Interleukin-13 / Q000378:metabolism*; D007377:Interleukin-3 / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism*; D015603:Keratinocytes / Q000502:physiology*; D018418:Th2 Cells / Q000502:physiology*
chemical_list: C578095:IL13 protein, human; C508598:IL4 protein, human; D018793:Interleukin-13; D007377:Interleukin-3; D015847:Interleukin-4
references.citation: J Pathol. 2012 Sep;228(1):1-7
references.pmid: 22692770
references.citation: J Clin Cell Immunol. 2011 Aug 10;2(3):
references.pmid: 21994899
references.citation: Allergy Asthma Immunol Res. 2012 Jan;4(1):12-6
references.pmid: 22211165
references.citation: J Invest Dermatol. 2014 May;134(5):1342-1350
references.pmid: 24280725
references.citation: Allergol Int. 2013 Jun;62(2):151-61
references.pmid: 23712284
references.citation: Clin Exp Allergy. 2013 Jun;43(6):586-98
references.pmid: 23711120
references.citation: Biochim Biophys Acta. 2009 Apr;1788(4):864-71
references.pmid: 18952050
references.citation: Nat Rev Mol Cell Biol. 2011 Aug 23;12(9):565-80
references.pmid: 21860392
references.citation: EMBO J. 2005 Mar 23;24(6):1146-56
references.pmid: 15775979
references.citation: Int J Mol Sci. 2013 Mar 26;14(4):6720-45
references.pmid: 23531535