title: Multiple sclerosis: clinical features and MRI findings in Northern China.
abstract: BACKGROUND
  Reports in Asian populations suggest that ethnic and geographical differences may influence susceptibility to multiple sclerosis (MS) and its clinical behaviors. Here, we sought to retrospectively survey clinical characteristics and MRI data in Chinese subjects with MS.
  
  
  METHODS
  We conducted a retrospective analysis in 117 patients with MS. The patients were divided into subgroups with optic-spinal form of multiple sclerosis (OSMS; n = 42) and classical multiple sclerosis (CMS; n = 75). Clinical characteristics, MRI finding and expanded disability status scale (EDSS) score were compared between the two groups.
  
  
  RESULTS
  In 117 MS patients, 64.1% patients were classified as having CMS and 35.9% OSMS forms. White blood cell counts of OSMS patients were significantly higher than those of CMS patients (P <0.05). The longitudinal fusion lesions of spinal cord on MRI were statistically significant between groups (P <0.05). Spinal cord MRI showed that MS lesions were longer, and revealed spinal cord swelling in patients with CMS, but atrophy in patients with OSMS. The EDSS score at five years was significantly higher in patients with OSMS than in those with CMS (P <0.05). Relapse rates of patients with OSMS were also higher than those of patients with CMS (P <0.01) within one to three years.
  
  
  CONCLUSIONS
  OSMS accounts for a higher proportion of MS populations in Northern China than in Western countries. MRI showed a longitudinally extensive spinal cord lesion in patients with OSMS and spinal cord swelling at onset.
authors.affiliation: Radiology Department, No, 1 Affiliated Hospital of Fuzhou General Hospital, 29 Xinquan Road, Putian, Fujian Province 351100, P,R, China. lizhaoruixin@gmail.com.
authors.forename: Tianran
authors.initials: T
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Xiao
authors.forename: Shengjun
authors.initials: S
authors.lastname: Li
authors.forename: Xiangke
authors.initials: X
authors.lastname: Du
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000145:classification* / Q000150:complications / Q000473:pathology*; D012189:Retrospective Studies; D055815:Young Adult
references.citation: Arch Neurol. 2012 Sep;69(9):1176-80
references.pmid: 22733096
references.citation: Hong Kong Med J. 2002 Apr;8(2):77-80
references.pmid: 11937660
references.citation: Nihon Rinsho. 2008 Jun;66(6):1112-6
references.pmid: 18540356
references.citation: Mult Scler. 2006 Aug;12(4):501-6
references.pmid: 16900765
references.citation: J Neurol Neurosurg Psychiatry. 2006 Jul;77(7):830-3
references.pmid: 16043456
references.citation: Neurology. 2010 Feb 2;74(5):427-34
references.pmid: 20054006
references.citation: J Neurol Sci. 2009 May 15;280(1-2):22-8
references.pmid: 19201428
references.citation: Neurology. 1996 Apr;46(4):907-11
references.pmid: 8780061
references.citation: N Engl J Med. 2000 Nov 16;343(20):1430-8
references.pmid: 11078767
references.citation: AJNR Am J Neuroradiol. 2011 Mar;32(3):515-21
references.pmid: 21310857
references.citation: Lancet Neurol. 2003 Feb;2(2):117-27
references.pmid: 12849268
references.citation: Neurology. 1983 Nov;33(11):1444-52
references.pmid: 6685237
references.citation: Ann Neurol. 2001 Jul;50(1):121-7
references.pmid: 11456302
references.citation: Clin Neurol Neurosurg. 2010 Sep;112(7):609-15
references.pmid: 20417027
references.citation: Brain. 1989 Dec;112 ( Pt 6):1419-28
references.pmid: 2597989
references.citation: Ann Neurol. 1996 Oct;40(4):569-74
references.pmid: 8871575
references.citation: J Neurol Sci. 1998 Jun 30;158(2):209-14
references.pmid: 9702693
references.citation: Brain. 1999 Sep;122 ( Pt 9):1689-96
references.pmid: 10468508
references.citation: Brain. 1989 Dec;112 ( Pt 6):1445-67
references.pmid: 2597990
references.citation: Acta Neurol Scand. 1993 Sep;88(3):178-83
references.pmid: 8256553
references.citation: Mult Scler. 2009 Feb;15(2):159-73
references.pmid: 18987106
references.citation: Neurology. 2006 May 23;66(10):1485-9
references.pmid: 16717206