title: Mast cell sarcoma: clinical management.
abstract: Mast cell sarcoma is a disorder that results in abnormal mast cells as identified by morphology, special stains, and in some publications, c-kit mutation analysis. It affects animal species such as canines more commonly than humans. In humans it is a very rare condition, with variable clinical presentation. There is no standard therapy for the disorder. It can affect any age group. It is occasionally associated with systemic mastocytosis and/or urticaria pigmentosa. The prognosis of mast cell sarcoma in published literature is very poor in humans.
authors.affiliation: Program of Excellence in Mast Cell and Eosinophil Disorders, Division of Allergic Disease, Department of Internal Medicine, W-15 Mayo Building, 200 First Street Southwest, Rochester, MN 55905, USA.
authors.forename: Catherine R
authors.initials: CR
authors.lastname: Weiler
authors.affiliation: Program of Excellence in Mast Cell and Eosinophil Disorders, Division of Allergic Disease, Department of Internal Medicine, W-15 Mayo Building, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: Butterfield.joseph@mayo.edu.
authors.forename: Joseph
authors.initials: J
authors.lastname: Butterfield
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D002648:Child; D003106:Colon / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D004285:Dogs; D005260:Female; D006801:Humans; D007830:Larynx / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D012515:Mast-Cell Sarcoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use
chemical_list: D047428:Protein Kinase Inhibitors
keywords: Clinical presentation of mast cell sarcoma; Mast cell sarcoma; Mastocytosis; Prognosis of mast cell sarcoma; Treatment of mast cell sarcoma