title: The emerging landscape of RORγt biology.
abstract: The transcription factor retinoid-related orphan receptor gamma t (RORγt) has emerged as an exciting target for inflammatory diseases. Xiao et al. (2014) show that a new class of RORγt antagonists can inhibit the inflammatory function of T helper 17 cells without altering RORγt occupancy on its target genes.
authors.affiliation: Merck Research Laboratories, Palo Alto, CA 94304, USA.
authors.forename: Jacob S
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Merck Research Laboratories, Palo Alto, CA 94304, USA. Electronic address: daniel.cua@merck.com.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Cua
mesh_terms: D000818:Animals; D044482:Benzeneacetamides / Q000494:pharmacology*; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D004077:Digoxin / Q000494:pharmacology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy*; D053263:Gene Regulatory Networks / Q000187:drug effects*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000494:pharmacology*; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000037:antagonists & inhibitors*; D016176:T-Lymphocyte Subsets / Q000187:drug effects*; D058504:Th17 Cells / Q000187:drug effects*
chemical_list: D044482:Benzeneacetamides; D001559:Benzhydryl Compounds; D006576:Heterocyclic Compounds, 4 or More Rings; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; C588348:TMP778; C000589554:TMP920; D004077:Digoxin