title: ADMET: ADipocyte METabolism mathematical model.
abstract: White fat cells have an important physiological role in maintaining triglyceride and free fatty acid levels due to their fundamental storage property, as well as determining insulin resistance. ADipocyte METabolism is a mathematical model that mimics the main metabolic pathways of human white fat cell, connecting inputs (composition of culture medium) to outputs (glycerol and free fatty acid release). It is based on a set of nonlinear differential equations, implemented in Simulink® and controlled by cellular energetic state. The validation of this model is based on a comparison between the simulation results and a set of experimental data collected from the literature.
authors.affiliation: a Interdepartmental Research Centre E. Piaggio, University of Pisa , Via Diotisalvi 2, 56126 Pisa , Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Micheloni
authors.forename: Gianni
authors.initials: G
authors.lastname: Orsi
authors.forename: Carmelo
authors.initials: C
authors.lastname: De Maria
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vozzi
mesh_terms: D052438:Adipocytes, White / Q000378:metabolism*; D002384:Catalysis; D003470:Culture Media; D005230:Fatty Acids, Nonesterified / Q000737:chemistry; D005990:Glycerol / Q000737:chemistry; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D008954:Models, Biological; D013997:Time Factors; D014280:Triglycerides / Q000737:chemistry
chemical_list: D003470:Culture Media; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides; D005990:Glycerol
keywords: adipocyte metabolism; biochemical pathways; mathematical modelling