title: Continuous attractor network model for conjunctive position-by-velocity tuning of grid cells.
abstract: The spatial responses of many of the cells recorded in layer II of rodent medial entorhinal cortex (MEC) show a triangular grid pattern, which appears to provide an accurate population code for animal spatial position. In layer III, V and VI of the rat MEC, grid cells are also selective to head-direction and are modulated by the speed of the animal. Several putative mechanisms of grid-like maps were proposed, including attractor network dynamics, interactions with theta oscillations or single-unit mechanisms such as firing rate adaptation. In this paper, we present a new attractor network model that accounts for the conjunctive position-by-velocity selectivity of grid cells. Our network model is able to perform robust path integration even when the recurrent connections are subject to random perturbations.
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Bailu
authors.initials: B
authors.lastname: Si
authors.affiliation: Center for Theoretical Neuroscience, Columbia University, New York, New York, United States of America.
authors.forename: Sandro
authors.initials: S
authors.lastname: Romani
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Misha
authors.initials: M
authors.lastname: Tsodyks
mesh_terms: D000818:Animals; D008962:Models, Theoretical; D009068:Movement; D012377:Rodentia / Q000502:physiology*
references.citation: Neural Comput. 2012 Sep;24(9):2280-317
references.pmid: 22594833
references.citation: Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3844-8
references.pmid: 7731993
references.citation: Nat Neurosci. 2013 Mar;16(3):318-24
references.pmid: 23334580
references.citation: Hippocampus. 2012 Apr;22(4):881-95
references.pmid: 21710546
references.citation: J Neurosci. 2006 Apr 19;26(16):4266-76
references.pmid: 16624947
references.citation: Science. 2006 May 5;312(5774):758-62
references.pmid: 16675704
references.citation: Nat Neurosci. 2007 Jun;10(6):682-4
references.pmid: 17486102
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14755-62
references.pmid: 18812502
references.citation: Neurobiol Learn Mem. 2009 Feb;91(2):186-96
references.pmid: 18929674
references.citation: PLoS Comput Biol. 2009 Feb;5(2):e1000291
references.pmid: 19229307
references.citation: Neuron. 2012 Feb 23;73(4):789-802
references.pmid: 22365551
references.citation: Nature. 2012 Dec 6;492(7427):72-8
references.pmid: 23222610
references.citation: Nat Rev Neurosci. 2006 Aug;7(8):663-78
references.pmid: 16858394
references.citation: Nat Rev Neurosci. 2009 Nov;10(11):792-802
references.pmid: 19812579
references.citation: Science. 2010 Jun 18;328(5985):1576-80
references.pmid: 20558721
references.citation: Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6716-20
references.pmid: 22493275
references.citation: Hippocampus. 2012 Apr;22(4):772-89
references.pmid: 21484936
references.citation: Science. 2010 Jun 18;328(5985):1573-6
references.pmid: 20558720
references.citation: Behav Neurosci. 2001 Dec;115(6):1212-23
references.pmid: 11770053
references.citation: Hippocampus. 1992 Jan;2(1):1-11
references.pmid: 1308170
references.citation: Annu Rev Neurosci. 2012;35:267-85
references.pmid: 22462545
references.citation: Int J Neural Syst. 2007 Aug;17(4):231-40
references.pmid: 17696288
references.citation: Neuron. 2013 Jan 9;77(1):141-54
references.pmid: 23312522
references.citation: Behav Brain Res. 2001 Jan 8;118(1):67-76
references.pmid: 11163635
references.citation: Neural Plast. 2008;2008:381243
references.pmid: 18769556
references.citation: Neurobiol Learn Mem. 2010 Oct;94(3):402-13
references.pmid: 20736074
references.citation: Nat Neurosci. 2010 Aug;13(8):987-94
references.pmid: 20657591
references.citation: Neurosci Lett. 1980 Apr;17(1-2):55-60
references.pmid: 6820482
references.citation: Front Neural Circuits. 2012 Apr 27;6:21
references.pmid: 22557949
references.citation: PLoS Comput Biol. 2010 Aug 05;6(8):
references.pmid: 20700490
references.citation: Hippocampus. 2009 May;19(5):480-6
references.pmid: 19072773
references.citation: Exp Brain Res. 1994;100(1):67-84
references.pmid: 7813654