title: Laparoscopic sleeve gastrectomy improves reproductive hormone levels in morbidly obese males -- a series of 28 cases.
abstract: BACKGROUND
  Obese males frequently present with low androgen levels that may improve after weight loss achieved by bariatric surgery. Laparoscopic sleeve gastrectomy (LSG) has been used often in the last decade as treatment for morbid obesity. The aim of this study was to evaluate modifications in the male reproductive hormone profile after LSG.
  
  
  METHODS
  The prospective study included 28 males with body mass index (BMI) 35 kg m2 who underwent LSG.Total Testosterone (TT), Sex Hormone Binding Globulin(SHBG) and Luteinizing hormone (LH), together with biochemical and anthropometric data, were evaluated at baseline and after LSG.
  
  
  RESULTS
  Baseline patients had a mean BMI of 50.10 (+-11.19)kg m2, SHBG 23.37 (+-17.47) nmol L, LH 3.83 (+-1.76)mUI ml and TT 8.31 (+-3.24) nmol L. After LSG, patients showed a mean BMI of 35.87 (+-7.02) kg m2 (p 0.001),SHBG 37.81 (+-18.95) nmol L (p 0.05), LH 4.76 (+-2.49)mUI ml (p 0.05), whereas mean TT was 12.7 (Â+-3.8) nmol L(p 0.001). The percentage of excess body weight loss (%EBL)was 43.07 (+-9.56) and metabolic syndrome prevalence decreased significantly from 75% to 25% (p 0.001).
  
  
  CONCLUSIONS
  Beyond BMI loss, LSG significantly improved reproductive hormone levels in morbidly obese males.
authors.forename: R
authors.initials: R
authors.lastname: Mihalca
authors.forename: C
authors.initials: C
authors.lastname: Copăescu
authors.forename: A
authors.initials: A
authors.lastname: Sirbu
authors.forename: S
authors.initials: S
authors.lastname: Florea
authors.forename: S
authors.initials: S
authors.lastname: Martin
authors.forename: C G
authors.initials: CG
authors.lastname: Barbu
authors.forename: S
authors.initials: S
authors.lastname: Fica
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015331:Cohort Studies; D005743:Gastrectomy / Q000379:methods; D006801:Humans; D010535:Laparoscopy; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000601:surgery*; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000150:complications / Q000601:surgery*; D015995:Prevalence; D013739:Testosterone / Q000097:blood*; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D000728:Androgens; D015415:Biomarkers; D013739:Testosterone