title: Lycojaponicuminol A-F: cytotoxic serratene triterpenoids from Lycopodium japonicum.
abstract: Six new serratene triterpenoids (1-6), together with nine known triterpenoid compounds were isolated from the extract of club moss Lycopodium japonicum. The structures of isolated compounds were established by spectroscopic methods. The cytotoxic activities of all compounds were evaluated against three human cancer cell lines in vitro by MTT assay. Compounds 2, 6-8 and 11 exhibited moderate activities against all three cell lines with IC50 values of 2.28-11.81 μg/mL.
authors.affiliation: Laboratory for Natural Product Chemistry, College of Pharmacy, South Central University for Nationalities, Wuhan 430074, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Laboratory for Natural Product Chemistry, College of Pharmacy, South Central University for Nationalities, Wuhan 430074, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yi
authors.affiliation: College of Chemistry and Material Sciences, South Central University for Nationalities, Wuhan 430074, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Laboratory for Natural Product Chemistry, College of Pharmacy, South Central University for Nationalities, Wuhan 430074, PR China.
authors.forename: Zhi-nan
authors.initials: ZN
authors.lastname: Mei
authors.affiliation: Laboratory for Natural Product Chemistry, College of Pharmacy, South Central University for Nationalities, Wuhan 430074, PR China. Electronic address: huxin5540@126.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Hu
authors.affiliation: Laboratory for Natural Product Chemistry, College of Pharmacy, South Central University for Nationalities, Wuhan 430074, PR China. Electronic address: yanggz888@126.com.
authors.forename: Guang-zhong
authors.initials: GZ
authors.lastname: Yang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D032502:Lycopodium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes
keywords: Cytotoxic; Lycopodiaceae; Lycopodium japonicum; Serratene triterpenoid