title: Outcomes of ethnic minority groups with node-positive, non-metastatic breast cancer in two tertiary referral centers in Sydney, Australia.
abstract: OBJECTIVE
  There is a lack of information in ethnic minority groups with regard to presentation and treatment of early node-positive breast cancer. We carried out a retrospective study of patients referred to two tertiary cancer centers in South Western Sydney, both of which serve a high proportion of this ethnic minority population.
  
  
  METHODS
  Women who had pathologically node-positive non-metastatic breast cancer (T1-3, N1-3, M0) diagnosed between 2003 and 2006 were studied, with variables of interest being tumor size, number of positive nodes, histological grade, hormone receptor status, age at diagnosis, country of birth and treatment. We compared the Asian and Western subgroups with regard to tumor characteristics, treatment and clinical outcomes.
  
  
  RESULTS
  A total of 652 eligible patients were identified, with a median follow-up of 6.1 years. Women with Asian backgrounds (n = 125, 20%) were significantly younger at presentation (48 years versus 55 years, p-value <0.0001) and more likely to undergo mastectomy (53% versus 39%, p-value 0.0009) and chemotherapy (86% versus 72%, p-value 0.0063) than their non-Asian counterparts. Tumor stage, grade and receptor status were not statistically different between these two groups. There were also no differences in disease-free survival and overall survival, with medians of 12.7 and 14.8 years respectively.
  
  
  CONCLUSIONS
  Women of Asian background are younger at diagnosis, which may reflect population epidemiology and likely results in higher uptake of chemotherapy. Higher mastectomy rates may be influenced by cultural factors. Future research is warranted to investigate potential differences in tumor biology, psychosocial, economic and cultural factors.
authors.affiliation: Department of Medical Oncology, Liverpool and Campbelltown Hospitals, New South Wales, Australia; Ingham Institute for Applied Medical Research, New South Wales, Australia; School of Medicine, University of New South Wales, New South Wales, Australia.
authors.forename: Stephanie H
authors.initials: SH
authors.lastname: Lim
authors.affiliation: Ingham Institute for Applied Medical Research, New South Wales, Australia; School of Medicine, University of New South Wales, New South Wales, Australia; Cancer Services, South Western Sydney Local Health District, New South Wales, Australia; School of Medicine, Molecular Medicine Research Group, University of Western Sydney, New South Wales, Australia.
authors.forename: Geoff P
authors.initials: GP
authors.lastname: Delaney
authors.affiliation: Ingham Institute for Applied Medical Research, New South Wales, Australia.
authors.forename: Joseph
authors.initials: J
authors.lastname: Descallar
authors.affiliation: Cancer Services, South Western Sydney Local Health District, New South Wales, Australia.
authors.forename: Phan
authors.initials: P
authors.lastname: Sayaloune
authors.affiliation: Cancer Services, South Western Sydney Local Health District, New South Wales, Australia.
authors.forename: George
authors.initials: G
authors.lastname: Papadatos
authors.affiliation: Department of Medical Oncology, Liverpool and Campbelltown Hospitals, New South Wales, Australia; Ingham Institute for Applied Medical Research, New South Wales, Australia; School of Medicine, University of New South Wales, New South Wales, Australia; Cancer Services, South Western Sydney Local Health District, New South Wales, Australia; School of Medicine, Molecular Medicine Research Group, University of Western Sydney, New South Wales, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: de Souza
mesh_terms: D001315:Australia; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008408:Mastectomy / Q000706:statistics & numerical data; D015999:Multivariate Analysis; D012189:Retrospective Studies; D062606:Tertiary Care Centers / Q000706:statistics & numerical data
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