title: Genetic predisposition to in situ and invasive lobular carcinoma of the breast.
abstract: Invasive lobular breast cancer (ILC) accounts for 10-15% of all invasive breast carcinomas. It is generally ER positive (ER+) and often associated with lobular carcinoma in situ (LCIS). Genome-wide association studies have identified more than 70 common polymorphisms that predispose to breast cancer, but these studies included predominantly ductal (IDC) carcinomas. To identify novel common polymorphisms that predispose to ILC and LCIS, we pooled data from 6,023 cases (5,622 ILC, 401 pure LCIS) and 34,271 controls from 36 studies genotyped using the iCOGS chip. Six novel SNPs most strongly associated with ILC/LCIS in the pooled analysis were genotyped in a further 516 lobular cases (482 ILC, 36 LCIS) and 1,467 controls. These analyses identified a lobular-specific SNP at 7q34 (rs11977670, OR (95%CI) for ILC = 1.13 (1.09-1.18), P = 6.0 × 10(-10); P-het for ILC vs IDC ER+ tumors = 1.8 × 10(-4)). Of the 75 known breast cancer polymorphisms that were genotyped, 56 were associated with ILC and 15 with LCIS at P<0.05. Two SNPs showed significantly stronger associations for ILC than LCIS (rs2981579/10q26/FGFR2, P-het = 0.04 and rs889312/5q11/MAP3K1, P-het = 0.03); and two showed stronger associations for LCIS than ILC (rs6678914/1q32/LGR6, P-het = 0.001 and rs1752911/6q14, P-het = 0.04). In addition, seven of the 75 known loci showed significant differences between ER+ tumors with IDC and ILC histology, three of these showing stronger associations for ILC (rs11249433/1p11, rs2981579/10q26/FGFR2 and rs10995190/10q21/ZNF365) and four associated only with IDC (5p12/rs10941679; rs2588809/14q24/RAD51L1, rs6472903/8q21 and rs1550623/2q31/CDCA7). In conclusion, we have identified one novel lobular breast cancer specific predisposition polymorphism at 7q34, and shown for the first time that common breast cancer polymorphisms predispose to LCIS. We have shown that many of the ER+ breast cancer predisposition loci also predispose to ILC, although there is some heterogeneity between ER+ lobular and ER+ IDC tumors. These data provide evidence for overlapping, but distinct etiological pathways within ER+ breast cancer between morphological subtypes.
authors.affiliation: Research Oncology, Division of Cancer Studies, Kings College London, Guy's Hospital, London, United Kingdom.
authors.forename: Elinor
authors.initials: E
authors.lastname: Sawyer
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Roylance
authors.affiliation: Research Oncology, Division of Cancer Studies, Kings College London, Guy's Hospital, London, United Kingdom.
authors.forename: Christos
authors.initials: C
authors.lastname: Petridis
authors.affiliation: Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom.
authors.forename: Mark N
authors.initials: MN
authors.lastname: Brook
authors.affiliation: Research Oncology, Division of Cancer Studies, Kings College London, Guy's Hospital, London, United Kingdom.
authors.forename: Salpie
authors.initials: S
authors.lastname: Nowinski
authors.affiliation: Biomedical Research Centre, King's College London, Guy's Hospital, London, United Kingdom.
authors.forename: Efterpi
authors.initials: E
authors.lastname: Papouli
authors.affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.
authors.forename: Olivia
authors.initials: O
authors.lastname: Fletcher
authors.affiliation: Research Oncology, Division of Cancer Studies, Kings College London, Guy's Hospital, London, United Kingdom.
authors.forename: Sarah
authors.initials: S
authors.lastname: Pinder
authors.affiliation: Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Hanby
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
authors.forename: Kelly
authors.initials: K
authors.lastname: Kohut
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
authors.forename: Patricia
authors.initials: P
authors.lastname: Gorman
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
authors.forename: Michele
authors.initials: M
authors.lastname: Caneppele
authors.affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Julian
authors.initials: J
authors.lastname: Peto
authors.affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Isabel
authors.initials: I
authors.lastname: Dos Santos Silva
authors.affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.
authors.forename: Nichola
authors.initials: N
authors.lastname: Johnson
authors.affiliation: Department of Molecular and Applied Biosciences, University of Westminster, London, United Kingdom.
authors.forename: Ruth
authors.initials: R
authors.lastname: Swann
authors.affiliation: Department of Molecular and Applied Biosciences, University of Westminster, London, United Kingdom.
authors.forename: Miriam
authors.initials: M
authors.lastname: Dwek
authors.affiliation: Department of Molecular and Applied Biosciences, University of Westminster, London, United Kingdom.
authors.forename: Katherine-Anne
authors.initials: KA
authors.lastname: Perkins
authors.affiliation: Research Oncology, Division of Cancer Studies, Kings College London, Guy's Hospital, London, United Kingdom.
authors.forename: Cheryl
authors.initials: C
authors.lastname: Gillett
authors.affiliation: Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom.
authors.forename: Richard
authors.initials: R
authors.lastname: Houlston
authors.affiliation: The Royal Marsden NHS Foundation Trust, London, United Kingdom.
authors.forename: Gillian
authors.initials: G
authors.lastname: Ross
authors.affiliation: The Royal Marsden NHS Foundation Trust, London, United Kingdom.
authors.forename: Paolo
authors.initials: P
authors.lastname: De Ieso
authors.affiliation: Department of Pathology, The University of Melbourne, Melbourne, Australia.
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Southey
authors.affiliation: Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia.
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.affiliation: NIHR Cambridge Biomedical Research Centre, Addenbrookes Hospital, Cambridge, United Kingdom.
authors.forename: Elena
authors.initials: E
authors.lastname: Provenzano
authors.affiliation: Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia.
authors.forename: Carmel
authors.initials: C
authors.lastname: Apicella
authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors.forename: Jelle
authors.initials: J
authors.lastname: Wesseling
authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors.forename: Sten
authors.initials: S
authors.lastname: Cornelissen
authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors.forename: Renske
authors.initials: R
authors.lastname: Keeman
authors.affiliation: David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, United States of America; Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Fasching
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
authors.forename: Sebastian M
authors.initials: SM
authors.lastname: Jud
authors.affiliation: Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: Arif B
authors.initials: AB
authors.lastname: Ekici
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Beckmann
authors.affiliation: Surgery, Clinical Science Institute, National University of Ireland, Galway, Ireland.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kerin
authors.affiliation: Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
authors.forename: Federick
authors.initials: F
authors.lastname: Marme
authors.affiliation: Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schneeweiss
authors.affiliation: Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Christof
authors.initials: C
authors.lastname: Sohn
authors.affiliation: Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany; Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Burwinkel
authors.affiliation: Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France; University Paris-Sud, UMRS 1018, Villejuif, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Guénel
authors.affiliation: Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France; University Paris-Sud, UMRS 1018, Villejuif, France.
authors.forename: Therese
authors.initials: T
authors.lastname: Truong
authors.affiliation: Université Paris Sorbonne Cité, UMR-S775 Inserm, Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Laurent-Puig
authors.affiliation: Centre Eugène Marquis, Department of Medical Oncology, Rennes, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Kerbrat
authors.affiliation: Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Stig E
authors.initials: SE
authors.lastname: Bojesen
authors.affiliation: Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Børge G
authors.initials: BG
authors.lastname: Nordestgaard
authors.affiliation: Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Sune F
authors.initials: SF
authors.lastname: Nielsen
authors.affiliation: Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Flyger
authors.affiliation: Genetic & Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre [CNIO], Madrid, Spain.
authors.forename: Roger L
authors.initials: RL
authors.lastname: Milne
authors.affiliation: Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain.
authors.forename: Jose Ignacio Arias
authors.initials: JI
authors.lastname: Perez
authors.affiliation: Servicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain.
authors.forename: Primitiva
authors.initials: P
authors.lastname: Menéndez
authors.affiliation: Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre [CNIO], Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Benitez
authors.affiliation: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Hermann
authors.initials: H
authors.lastname: Brenner
authors.affiliation: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Aida Karina
authors.initials: AK
authors.lastname: Dieffenbach
authors.affiliation: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Arndt
authors.affiliation: Saarland Cancer Registry, Saarbrücken, Germany.
authors.forename: Christa
authors.initials: C
authors.lastname: Stegmaier
authors.affiliation: Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
authors.forename: Alfons
authors.initials: A
authors.lastname: Meindl
authors.affiliation: Institute of Human Genetics, Technische Universität, Munich, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Lichtner
authors.affiliation: Centre for Familial Breast and Ovarian Cancer and Centre for Integrated Oncology, University Hospital Cologne, Cologne, Germany.
authors.forename: Rita K
authors.initials: RK
authors.lastname: Schmutzler
authors.affiliation: Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Lochmann
authors.affiliation: Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany.
authors.forename: Hiltrud
authors.initials: H
authors.lastname: Brauch
authors.affiliation: Institute of Pathology, Medical Faculty of the University of Bonn, Bonn, Germany.
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fischer
authors.affiliation: Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany.
authors.forename: Yon-Dschun
authors.initials: YD
authors.lastname: Ko
authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Heli
authors.initials: H
authors.lastname: Nevanlinna
authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Taru A
authors.initials: TA
authors.lastname: Muranen
authors.affiliation: Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Kristiina
authors.initials: K
authors.lastname: Aittomäki
authors.affiliation: Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Carl
authors.initials: C
authors.lastname: Blomqvist
authors.affiliation: Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Bogdanova
authors.affiliation: Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
authors.forename: Thilo
authors.initials: T
authors.lastname: Dörk
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Annika
authors.initials: A
authors.lastname: Lindblom
authors.affiliation: Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Sara
authors.initials: S
authors.lastname: Margolin
authors.affiliation: School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Joensuu, Finland; Cancer Center, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Arto
authors.initials: A
authors.lastname: Mannermaa
authors.affiliation: School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Joensuu, Finland; Cancer Center, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Vesa
authors.initials: V
authors.lastname: Kataja
authors.affiliation: School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Joensuu, Finland; Cancer Center, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Veli-Matti
authors.initials: VM
authors.lastname: Kosma
authors.affiliation: School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Joensuu, Finland; Cancer Center, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Jaana M
authors.initials: JM
authors.lastname: Hartikainen
authors.affiliation: Department of Genetics, QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
authors.forename: Georgia
authors.initials: G
authors.lastname: Chenevix-Trench
authors.affiliation: Peter MacCallum Cancer Center, Melbourne, Australia.
authors.affiliation: Vesalius Research Center (VRC), VIB, Leuven, Belgium; Department of Oncology, University of Leuven, Leuven, Belgium.
authors.forename: Diether
authors.initials: D
authors.lastname: Lambrechts
authors.affiliation: University Hospital Gashuisberg, Leuven, Belgium.
authors.forename: Caroline
authors.initials: C
authors.lastname: Weltens
authors.affiliation: University Hospital Gashuisberg, Leuven, Belgium.
authors.forename: Erik
authors.initials: E
authors.lastname: Van Limbergen
authors.affiliation: University Hospital Gashuisberg, Leuven, Belgium.
authors.forename: Sigrid
authors.initials: S
authors.lastname: Hatse
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Jenny
authors.initials: J
authors.lastname: Chang-Claude
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Rudolph
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Seibold
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Flesch-Janys
authors.affiliation: Unit of Molecular Bases of Genetic Risk and Genetic Testing, Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy; IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Radice
authors.affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Peterlongo
authors.affiliation: Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Bonanni
authors.affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Volorio
authors.affiliation: Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia; Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia.
authors.forename: Graham G
authors.initials: GG
authors.lastname: Giles
authors.affiliation: Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia; Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Severi
authors.affiliation: Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia; Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia.
authors.forename: Laura
authors.initials: L
authors.lastname: Baglietto
authors.affiliation: Department of Pathology, The Alfred Hospital, Prahran, Victoria, Australia.
authors.forename: Catriona A
authors.initials: CA
authors.lastname: McLean
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
authors.forename: Fredrick
authors.initials: F
authors.lastname: Schumacher
authors.affiliation: Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, United States of America.
authors.forename: Loic
authors.initials: L
authors.lastname: Le Marchand
authors.affiliation: Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.
authors.forename: Jacques
authors.initials: J
authors.lastname: Simard
authors.affiliation: Department of Medicine, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Goldberg
authors.affiliation: Département de médecine sociale et préventive, Département de santé environnementale et santé au travail, Université de Montréal, Montreal, Quebec, Canada.
authors.forename: France
authors.initials: F
authors.lastname: Labrèche
authors.affiliation: Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.
authors.forename: Martine
authors.initials: M
authors.lastname: Dumont
authors.affiliation: Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway; Faculty of Medicine (Faculty Division Ahus), UiO, Oslo, Norway.
authors.forename: Vessela
authors.initials: V
authors.lastname: Kristensen
authors.affiliation: Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab/Oulu University Hospital, Oulu, Finland.
authors.forename: Robert
authors.initials: R
authors.lastname: Winqvist
authors.affiliation: Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab/Oulu University Hospital, Oulu, Finland.
authors.forename: Katri
authors.initials: K
authors.lastname: Pylkäs
authors.affiliation: Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland.
authors.forename: Arja
authors.initials: A
authors.lastname: Jukkola-Vuorinen
authors.affiliation: Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland.
authors.forename: Saila
authors.initials: S
authors.lastname: Kauppila
authors.affiliation: Ontario Cancer Genetics Network, Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Irene L
authors.initials: IL
authors.lastname: Andrulis
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Knight
authors.affiliation: Ontario Cancer Genetics Network, Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: Gord
authors.initials: G
authors.lastname: Glendon
authors.affiliation: Laboratory Medicine Program, University Health Network, Toronto, Ontario; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Anna Marie
authors.initials: AM
authors.lastname: Mulligan
authors.affiliation: Department of Human Genetics & Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Devillee
authors.affiliation: Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Rob A E M
authors.initials: RA
authors.lastname: Tollenaar
authors.affiliation: Family Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
authors.forename: Caroline M
authors.initials: CM
authors.lastname: Seynaeve
authors.affiliation: Family Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
authors.forename: Mieke
authors.initials: M
authors.lastname: Kriege
authors.affiliation: Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, United States of America.
authors.forename: Jonine
authors.initials: J
authors.lastname: Figueroa
authors.affiliation: Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, United States of America.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.affiliation: Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, United States of America.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Sherman
authors.affiliation: Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
authors.forename: Maartje J
authors.initials: MJ
authors.lastname: Hooning
authors.affiliation: Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
authors.forename: Antoinette
authors.initials: A
authors.lastname: Hollestelle
authors.affiliation: Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Ans M W
authors.initials: AM
authors.lastname: van den Ouweland
authors.affiliation: Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Carolien H M
authors.initials: CH
authors.lastname: van Deurzen
authors.affiliation: Human Genetics Division, Genome Institute of Singapore, Singapore.
authors.forename: Jingmei
authors.initials: J
authors.lastname: Li
authors.affiliation: Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Kamila
authors.initials: K
authors.lastname: Czene
authors.affiliation: Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Keith
authors.initials: K
authors.lastname: Humphreys
authors.affiliation: CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Angela
authors.initials: A
authors.lastname: Cox
authors.affiliation: Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Simon S
authors.initials: SS
authors.lastname: Cross
authors.affiliation: CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Malcolm W R
authors.initials: MW
authors.lastname: Reed
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Mitul
authors.initials: M
authors.lastname: Shah
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Lubinski
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland; Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jaworska-Bieniek
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Durda
authors.affiliation: Division of Genetics and Epidemiology and Division of Breast Cancer Research, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.
authors.forename: Anthony
authors.initials: A
authors.lastname: Swerdlow
authors.affiliation: Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom.
authors.forename: Alan
authors.initials: A
authors.lastname: Ashworth
authors.affiliation: Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Orr
authors.affiliation: Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom.
authors.forename: Minouk
authors.initials: M
authors.lastname: Schoemaker
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Fergus J
authors.initials: FJ
authors.lastname: Couch
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Emily
authors.initials: E
authors.lastname: Hallberg
authors.affiliation: Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre [CNIO], Madrid, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: González-Neira
authors.affiliation: Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre [CNIO], Madrid, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Pita
authors.affiliation: Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre [CNIO], Madrid, Spain.
authors.forename: M Rosario
authors.initials: MR
authors.lastname: Alonso
authors.affiliation: McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Tessier
authors.affiliation: McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Vincent
authors.affiliation: McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada.
authors.forename: Francois
authors.initials: F
authors.lastname: Bacot
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Manjeet K
authors.initials: MK
authors.lastname: Bolla
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Joe
authors.initials: J
authors.lastname: Dennis
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Michailidou
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Dunning
authors.affiliation: Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Hall
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Doug
authors.initials: D
authors.lastname: Easton
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Pharoah
authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors.forename: Marjanka K
authors.initials: MK
authors.lastname: Schmidt
authors.affiliation: Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
authors.forename: Ian
authors.initials: I
authors.lastname: Tomlinson
authors.affiliation: Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom; Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Garcia-Closas
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D002278:Carcinoma in Situ / Q000235:genetics*; D018275:Carcinoma, Lobular / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
references.citation: Nat Genet. 2013 Apr;45(4):353-61, 361e1-2
references.pmid: 23535729
references.citation: Nature. 2007 Jun 28;447(7148):1087-93
references.pmid: 17529967
references.citation: Nat Genet. 2007 Jul;39(7):865-9
references.pmid: 17529974
references.citation: Nat Genet. 2013 Apr;45(4):362-70, 370e1-2
references.pmid: 23535730
references.citation: J Clin Oncol. 2008 Jun 20;26(18):3006-14
references.pmid: 18458044
references.citation: Hum Mol Genet. 2012 Dec 15;21(24):5373-84
references.pmid: 22976474
references.citation: Cancer. 2001 May 15;91(10):1862-9
references.pmid: 11346867
references.citation: Nat Genet. 2013 Apr;45(4):392-8, 398e1-2
references.pmid: 23535733
references.citation: Maturitas. 2013 Jul;75(3):232-40
references.pmid: 23664318
references.citation: Nat Genet. 2010 Oct;42(10):885-92
references.pmid: 20852631
references.citation: Breast Cancer Res. 2010;12(6):R106
references.pmid: 21143857
references.citation: Int J Cancer. 2012 Sep 15;131(6):E884-96
references.pmid: 22573479
references.citation: Nat Genet. 2011 Jul 31;43(9):825-7
references.pmid: 21804547
references.citation: Cancer. 2004 Jan 15;100(2):238-44
references.pmid: 14716756
references.citation: Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2222-31
references.pmid: 21795498
references.citation: Gastroenterology. 2001 Dec;121(6):1348-53
references.pmid: 11729114
references.citation: Nature. 2012 Oct 4;490(7418):61-70
references.pmid: 23000897
references.citation: Cancer. 2011 Jul 15;117(14):3112-7
references.pmid: 21271559
references.citation: Nat Genet. 2008 Jun;40(6):703-6
references.pmid: 18438407
references.citation: Ann Oncol. 2006 Aug;17(8):1228-33
references.pmid: 16740599
references.citation: Lancet Oncol. 2006 Nov;7(11):910-8
references.pmid: 17081916
references.citation: Nat Genet. 2007 Jul;39(7):870-4
references.pmid: 17529973
references.citation: J Natl Cancer Inst. 2011 Mar 2;103(5):425-35
references.pmid: 21263130
references.citation: J Clin Oncol. 2005 Aug 20;23(24):5534-41
references.pmid: 16110014
references.citation: Bioinformatics. 2010 Sep 1;26(17):2190-1
references.pmid: 20616382
references.citation: Nat Genet. 2009 May;41(5):579-84
references.pmid: 19330030
references.citation: Nat Genet. 2009 Mar;41(3):324-8
references.pmid: 19219042
references.citation: Nat Genet. 2011 Oct 30;43(12):1210-4
references.pmid: 22037553
references.citation: Nat Genet. 2009 May;41(5):585-90
references.pmid: 19330027
references.citation: Cancer. 2004 Jun 15;100(12):2562-72
references.pmid: 15197797
references.citation: Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20725-9
references.pmid: 22143793
references.citation: Cancer. 2002 Mar 15;94(6):1626-35
references.pmid: 11920521
references.citation: J Clin Oncol. 2005 Jan 1;23(1):41-8
references.pmid: 15625359
references.citation: J Pathol. 2008 Oct;216(2):141-50
references.pmid: 18720457
references.citation: Hum Mol Genet. 2011 Dec 1;20(23):4693-706
references.pmid: 21852249
references.citation: Nat Genet. 2012 Jan 22;44(3):312-8
references.pmid: 22267197
references.citation: Breast J. 2007 Mar-Apr;13(2):172-9
references.pmid: 17319859
references.citation: Nat Genet. 2010 Jun;42(6):504-7
references.pmid: 20453838