title: Origin of subdiffusion of water molecules on cell membrane surfaces.
abstract: Water molecules play an important role in providing unique environments for biological reactions on cell membranes. It is widely believed that water molecules form bridges that connect lipid molecules and stabilize cell membranes. Using all-atom molecular dynamics simulations, we show that translational and rotational diffusion of water molecules on lipid membrane surfaces exhibit subdiffusion and aging. Moreover, we provide evidence that both divergent mean trapping time (continuous-time random walk) and long-correlated noise (fractional Brownian motion) contribute to this subdiffusion. These results suggest that subdiffusion on cell membranes causes the water retardation, an enhancement of cell membrane stability, and a higher reaction efficiency.
authors.affiliation: Department of Mechanical Engineering, Keio University, 3-4-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Yamamoto
authors.affiliation: Department of Mechanical Engineering, Keio University, 3-4-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Akimoto
authors.affiliation: Department of Pharmacology, School of Medicine, Keio University, 35 Shinanomachi, Shinju-ku, Tokyo 160-8582, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Yasui
authors.affiliation: Department of Mechanical Engineering, Keio University, 3-4-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Yasuoka
mesh_terms: D002462:Cell Membrane / Q000737:chemistry*; D004058:Diffusion; D008563:Membrane Lipids / Q000737:chemistry*; D008956:Models, Chemical; D056004:Molecular Dynamics Simulation; D013499:Surface Properties; D014867:Water / Q000737:chemistry*
chemical_list: D008563:Membrane Lipids; D014867:Water
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