title: Sleep reduces false memory in healthy older adults.
abstract: OBJECTIVE
  To investigate the effects of post-learning sleep and sleep architecture on false memory in healthy older adults.
  
  
  METHODS
  Balanced, crossover design. False memory was induced using the Deese-Roediger-McDermott (DRM) paradigm and assessed following nocturnal sleep and following a period of daytime wakefulness. Post-learning sleep structure was evaluated using polysomnography (PSG).
  
  
  METHODS
  Sleep research laboratory.
  
  
  METHODS
  Fourteen healthy older adults from the Singapore-Longitudinal Aging Brain Study (mean age ± standard deviation = 66.6 ± 4.1 y; 7 males).
  
  
  RESULTS
  At encoding, participants studied lists of words that were semantically related to non-presented critical lures. At retrieval, they made "remember"/"know" and "new" judgments. Compared to wakefulness, post-learning sleep was associated with reduced "remember" responses, but not "know" responses to critical lures. In contrast, there were no significant differences in the veridical recognition of studied words, false recognition of unrelated distractors, discriminability, or response bias between the sleep and the wake conditions. More post-learning slow wave sleep was associated with greater reduction in false memory.
  
  
  CONCLUSIONS
  In healthy older adults, sleep facilitates the reduction in false memory without affecting veridical memory. This benefit correlates with the amount of slow wave sleep in the post-learning sleep episode.
authors.affiliation: Centre for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore.
authors.forename: June C
authors.initials: JC
authors.lastname: Lo
authors.affiliation: Centre for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore.
authors.forename: Sam K Y
authors.initials: SK
authors.lastname: Sim
authors.affiliation: Centre for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore.
authors.forename: Michael W L
authors.initials: MW
authors.lastname: Chee
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D018592:Cross-Over Studies; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000503:physiopathology; D011939:Mental Recall / Q000502:physiology; D017286:Polysomnography; D021641:Recognition, Psychology / Q000502:physiology; D012094:Repression, Psychology; D012660:Semantics; D012846:Singapore; D012890:Sleep / Q000502:physiology*; D013997:Time Factors; D014851:Wakefulness / Q000502:physiology
keywords: Declarative memory; false memory; memory consolidation; sleep; slow wave sleep
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