title: Sasa quelpaertensis leaf extract improves high fat diet-induced lipid abnormalities and regulation of lipid metabolism genes in rats.
abstract: Sasa quelpaertensis is a bamboo leaf that is only grown on Jeju Island in South Korea. It is used as a bamboo tea that is consumed for therapeutic purposes, particularly for its anti-diabetic, diuretic, and anti-inflammatory effects. This study investigated the effect of S. quelpaertensis leaf extract (SQE) on high fat-induced lipid abnormalities and regulation of lipid metabolism-related gene expressions in rats. SQE supplementation significantly decreased the levels of plasma triglycerides, total cholesterol, and low-density lipoprotein cholesterol as well as the atherogenic index. SQE restored levels of plasma high-density lipoprotein cholesterol, which were lowered by a high fat diet. Plasma and cardiac resistin levels were also significantly decreased by SQE supplementation. In adipose tissue, mRNA levels of CAAT/enhancer-binding protein β (C/EBPβ) were suppressed in the SQE group. SQE supplementation decreased the accumulation of lipid droplets, inflammatory cell infiltrations, levels of triglycerides, and total lipids in the liver and effectively down-regulated expression of sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthetase (FAS), and uncoupling protein 2 (UCP-2). These results suggest that SQE may be a potential treatment for high fat-related disorders by improving lipid profiles and modulating lipid metabolism.
authors.affiliation: 1 Department of Nutritional Science and Food Management, Ewha Womans University , Seoul, Korea.
authors.forename: Jina
authors.initials: J
authors.lastname: Kim
authors.forename: Yoo-Sun
authors.initials: YS
authors.lastname: Kim
authors.forename: Hyun Ah
authors.initials: HA
authors.lastname: Lee
authors.forename: Ji Ye
authors.initials: JY
authors.lastname: Lim
authors.forename: Mina
authors.initials: M
authors.lastname: Kim
authors.forename: Oran
authors.initials: O
authors.lastname: Kwon
authors.forename: Hee-Chul
authors.initials: HC
authors.lastname: Ko
authors.forename: Se-Jae
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jae-Ho
authors.initials: JH
authors.lastname: Shin
authors.forename: Yuri
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents; D002784:Cholesterol / Q000097:blood; D004032:Diet; D059305:Diet, High-Fat / Q000009:adverse effects*; D015536:Down-Regulation; D064429:Fatty Acid Synthases / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects*; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D007473:Ion Channels / Q000235:genetics; D050356:Lipid Metabolism / Q000235:genetics*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D056910:Republic of Korea; D052243:Resistin / Q000032:analysis; D031787:Sasa / Q000737:chemistry*; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics; D014280:Triglycerides / Q000097:blood; D000071246:Uncoupling Protein 2
chemical_list: D019440:Anti-Obesity Agents; D007473:Ion Channels; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D024101:Mitochondrial Proteins; D010936:Plant Extracts; D052243:Resistin; D051780:Sterol Regulatory Element Binding Protein 1; D014280:Triglycerides; C000604391:Ucp2 protein, rat; D000071246:Uncoupling Protein 2; D002784:Cholesterol; D064429:Fatty Acid Synthases
keywords: Sasa quelpaertensis leaf; gene expression; high-fat diet; lipid metabolism; lipid profile