title: Structural characterization of an acetylated glucomannan with antiinflammatory activity and gastroprotective property from Cyrtopodium andersonii.
abstract: A polysaccharide with an estimated weight-average molar mass of 5.35×10(5) was obtained from an aqueous extract of pseudobulbs of Cyrtopodium andersonii R. Br. It was composed of d-glucose and d-mannose in 1:3 molar ratio. Chemical and spectroscopic analyses revealed a linear structure of the polymer with a backbone composed of (1→4)-linked β-d-glucopyranosyl and mannopyranosyl units slightly branched at C-2, C-3, and C-6 by side chains, as terminal non reducing residues of d-mannopyranose and d-glucopyranose. It was found to contain 14.6% of acetyl groups substituted at C-2 of (1→4)-linked β-d-mannopyranosyl units. The acetylated glucomannan demonstrated antiinflammatory and antiulcerogenic activities.
authors.affiliation: Laboratório de Química de Plantas Medicinais, Núcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, PO Box 68045, CEP 21941-971 Rio de Janeiro, Brazil. Electronic address: parente@pq.cnpq.br.
authors.forename: José P
authors.initials: JP
authors.lastname: Parente
authors.affiliation: Laboratório de Química de Plantas Medicinais, Núcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, PO Box 68045, CEP 21941-971 Rio de Janeiro, Brazil.
authors.forename: Camila R
authors.initials: CR
authors.lastname: Adão
authors.affiliation: Laboratório de Química de Plantas Medicinais, Núcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, PO Box 68045, CEP 21941-971 Rio de Janeiro, Brazil.
authors.forename: Bernadete P
authors.initials: BP
authors.lastname: da Silva
authors.affiliation: Laboratório Multiusuário de Análises por Ressonância Magnética Nuclear, Núcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, CEP 21941-902 Rio de Janeiro, Brazil.
authors.forename: Luzineide W
authors.initials: LW
authors.lastname: Tinoco
mesh_terms: D000107:Acetylation; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D000431:Ethanol; D008297:Male; D008351:Mannans / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use*; D051379:Mice; D029595:Orchidaceae / Q000737:chemistry*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D008351:Mannans; C022901:(1-6)-alpha-glucomannan; D000431:Ethanol; D002351:Carrageenan
keywords: Acetylated glucomannan; Antiinflammatory activity; Cyrtopodium andersonii; Gastroprotective property; Orchidaceae