title: Association between single nucleotide polymorphisms (SNPs) of XRCC2 and XRCC3 homologous recombination repair genes and triple-negative breast cancer in Polish women.
abstract: XRCC2 and XRCC3 genes involved in homologous recombination repair (HRR) of DNA and in the maintenance of the genome integrity play a crucial role in protecting against mutations that lead to cancer. The aim of the present work was to evaluate associations between the risk of triple-negative breast cancer (TNBC) and polymorphisms in the genes, encoding for two key proteins of HRR: XRCC2 Arg188His (c. 563 G>A; rs3218536, Genbank Accession Number NT 007914) and XRCC3 Thr241Met (c. 722 C>T; rs861539, Genbank Accession Number NT 026437). The polymorphisms of the XRCC2 and XRCC3 were investigated by PCR-RFLP in 70 patients with TNBC and 70 age- and sex-matched non-cancer controls. In the present work, a relationship was identified between XRCC2 Arg188His polymorphism and the incidence of triple-negative breast cancer. The 188His allele and 188His/His homozygous variant increased cancer risk. An association was confirmed between XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms and TNBC progression, assessed by the degree of lymph node metastases and histological grades. In conclusion, XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be regarded as predictive factors of triple-negative breast cancer in female population.
authors.affiliation: Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother's Memorial Hospital, Rzgowska 281/289, 93-338, Lodz, Poland, smolbea@wp.pl.
authors.forename: Beata
authors.initials: B
authors.lastname: Smolarz
authors.forename: Marianna
authors.initials: M
authors.lastname: Makowska
authors.forename: Dariusz
authors.initials: D
authors.lastname: Samulak
authors.forename: Magdalena M
authors.initials: MM
authors.lastname: Michalska
authors.forename: Ewa
authors.initials: E
authors.lastname: Mojs
authors.forename: Maciej
authors.initials: M
authors.lastname: Wilczak
authors.forename: Hanna
authors.initials: H
authors.lastname: Romanowicz
mesh_terms: D000328:Adult; D000368:Aged; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D064726:Triple Negative Breast Neoplasms / Q000453:epidemiology*
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3; C113187:XRCC2 protein, human
references.citation: Curr Opin Genet Dev. 2000 Apr;10(2):157-61
references.pmid: 10753784
references.citation: Cancer Epidemiol. 2010 Feb;34(1):85-92
references.pmid: 20004634
references.citation: Breast Cancer Res Treat. 2008 Dec;112(3):575-9
references.pmid: 18188695
references.citation: Breast Cancer Res Treat. 2011 Feb;125(3):827-35
references.pmid: 20640595
references.citation: Cancer. 2007 May 1;109(9):1721-8
references.pmid: 17387718
references.citation: Breast Cancer Res Treat. 2010 Aug;122(3):813-22
references.pmid: 20054644
references.citation: Mutat Res. 2008 Dec 15;648(1-2):65-72
references.pmid: 18977234
references.citation: Eur J Cancer. 2009 Sep;45 Suppl 1:27-40
references.pmid: 19775602
references.citation: Eur J Gynaecol Oncol. 2012;33(2):145-50
references.pmid: 22611952
references.citation: J Cancer Res Clin Oncol. 2011 Feb;137(2):183-92
references.pmid: 21069385
references.citation: Br J Cancer. 2004 May 17;90(10):2002-5
references.pmid: 15138485
references.citation: Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):1016-9
references.pmid: 18398049
references.citation: Tohoku J Exp Med. 2011;224(3):201-8
references.pmid: 21701125
references.citation: Cancer Detect Prev. 2006;30(4):313-21
references.pmid: 16963196
references.citation: Biomarkers. 2007 Sep-Oct;12(5):523-32
references.pmid: 17701750
references.citation: Eur J Gynaecol Oncol. 2005;26(6):589-98
references.pmid: 16398215
references.citation: Nature. 2006 Jun 22;441(7096):1011-4
references.pmid: 16791200
references.citation: Pol J Pathol. 2013 Apr;64(1):39-43
references.pmid: 23625599
references.citation: Mutat Res. 2003 Nov 27;532(1-2):103-15
references.pmid: 14643432
references.citation: Hum Mol Genet. 2002 Jun 1;11(12):1399-407
references.pmid: 12023982
references.citation: Breast Cancer Res. 2010;12 Suppl 2:S3
references.pmid: 21050424
references.citation: Annu Rev Biochem. 2008;77:229-57
references.pmid: 18275380
references.citation: Cancer Genet Cytogenet. 2007 Oct 1;178(1):65-9
references.pmid: 17889711
references.citation: PLoS One. 2013 Sep 09;8(9):e75153
references.pmid: 24040396
references.citation: Lancet Oncol. 2007 Mar;8(3):235-44
references.pmid: 17329194
references.citation: Cancer Lett. 2005 Mar 10;219(2):125-35
references.pmid: 15723711
references.citation: Int J Cancer. 2004 Mar;109(1):95-101
references.pmid: 14735473
references.citation: Carcinogenesis. 1999 May;20(5):743-8
references.pmid: 10334189
references.citation: Cancer Res. 1999 Jun 1;59(11):2557-61
references.pmid: 10363972
references.citation: Br J Cancer. 2000 Nov;83(10):1309-17
references.pmid: 11044355
references.citation: Breast Cancer Res Treat. 2010 Dec;124(3):765-9
references.pmid: 20396943
references.citation: Cancer Epidemiol Biomarkers Prev. 2004 Apr;13(4):520-4
references.pmid: 15066914
references.citation: Exp Mol Pathol. 2009 Aug;87(1):32-5
references.pmid: 19426727
references.citation: Breast Cancer Res Treat. 2010 Aug;123(1):219-25
references.pmid: 20127279
references.citation: Cancer Res. 2000 Aug 15;60(16):4519-25
references.pmid: 10969801
references.citation: Pol J Pathol. 2009;60(2):76-80
references.pmid: 19886181
references.citation: Mech Ageing Dev. 2002 Apr 30;123(8):907-15
references.pmid: 12044939
references.citation: Breast Cancer Res Treat. 2010 Jun;121(2):439-43
references.pmid: 19789975
references.citation: Genes Dev. 2005 Dec 15;19(24):2925-40
references.pmid: 16357213
references.citation: Hum Mol Genet. 2002 Jun 1;11(12):1433-8
references.pmid: 12023985
references.citation: Breast Cancer Res Treat. 2007 Jun;103(2):209-17
references.pmid: 17063276
references.citation: Genet Mol Res. 2008 Jul 01;7(3):574-82
references.pmid: 18752184
references.citation: Mol Biol Rep. 2013 Jan;40(1):665-8
references.pmid: 23065228
references.citation: Carcinogenesis. 2002 May;23(5):687-96
references.pmid: 12016139
references.citation: Int J Cancer. 2000 May 15;86(4):494-500
references.pmid: 10797261
references.citation: Genes Chromosomes Cancer. 2000 Jul;28(3):308-17
references.pmid: 10862037