title: Serum 25-hydroxyvitamin D and incidence of diabetes in elderly people: the PRO.V.A. study.
abstract: BACKGROUND
  Increasing research has shown that low levels of serum 25-hydroxyvitamin (25OHD) predict the onset of diabetes, but no research is available on this issue in elderly people.
  
  
  OBJECTIVE
  Our objective was to examine whether low serum levels of 25OHD are associated with a higher risk of incident type 2 diabetes over a lengthy follow-up in a representative group of elderly people.
  
  
  METHODS
  This was a population-based cohort study as part of the Progetto Veneto Anziani (Pro.V.A.) Study over a follow-up of 4.4 years in the general community.
  
  
  METHODS
  PARTICIPANTS included 2227 participants (1728 with follow-up visits and 499 died during the follow-up) over 65 years of age without diabetes at baseline, of 2352 initially included.
  
  
  METHODS
  The main outcome measure was incident diabetes.
  
  
  RESULTS
  There were no baseline differences in known factors for the onset of diabetes (body mass index, waist circumference, total cholesterol, renal function, and hemoglobin A1c levels) between the groups with different serum 25OHD levels (≤ 25, 25-50, 50-75, and ≥ 75 nmol/L). Over a 4.4-year follow-up, 291 individuals developed diabetes, with an incidence of 28 events per 1000 person-years. No significant difference in the incidence of diabetes emerged between the baseline 25OHD groups. Cox's regression analysis, adjusted for potential confounders, revealed no relationship between low vitamin D levels and incident diabetes during the follow-up (hazard ratio [HR] = 1.05, 95% confidence interval [CI] = 0.76-1.45, P = .77; HR = 1.44, 95% CI = 0.95-1.98, P = .12; and HR = 1.37, 95% CI = 0.87-2.16, P = .17 for those with 25OHD ≤25, 25-50, and 50-75 nmol/L, respectively).
  
  
  CONCLUSIONS
  Baseline serum concentrations of 25OHD were not associated with the incidence of diabetes in community-dwelling elderly people over a follow-up of 4.4 years.
authors.affiliation: Department of Medicine (N.V., G.S., M.D.R., F.B., E.D.T., E.M.), Geriatrics Division; Department of Medical and Surgical Sciences (S.Z., E.M.); and Department of Cardiac, Thoracic, and Vascular Sciences (E.P.), Unit of Biostatistics, Epidemiology, and Public Health, University of Padova, 35128 Padova, Italy; National Research Council (S.Z., G.C., E.M.), Aging Branch, Institute of Neuroscience, 35128 Padova, Italy; Azienda Unità Locale Socio Sanitaria 16, 35127 Padova (M.-C.C.), Padova, Italy; and Internal Medicine Division (G.B.), Azienda Ospedaliera, 35128 Padova, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Veronese
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sergi
authors.forename: Marina
authors.initials: M
authors.lastname: De Rui
authors.forename: Francesco
authors.initials: F
authors.lastname: Bolzetta
authors.forename: Elena Debora
authors.initials: ED
authors.lastname: Toffanello
authors.forename: Sabina
authors.initials: S
authors.lastname: Zambon
authors.forename: Maria-Chiara
authors.initials: MC
authors.lastname: Corti
authors.forename: Leonardo
authors.initials: L
authors.lastname: Sartori
authors.forename: Estella
authors.initials: E
authors.lastname: Musacchio
authors.forename: Giovannella
authors.initials: G
authors.lastname: Baggio
authors.forename: Gaetano
authors.initials: G
authors.lastname: Crepaldi
authors.forename: Egle
authors.initials: E
authors.lastname: Perissinotto
authors.forename: Enzo
authors.initials: E
authors.lastname: Manzato
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000453:epidemiology
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D