title: Sensory TRP channel interactions with endogenous lipids and their biological outcomes.
abstract: Lipids have long been studied as constituents of the cellular architecture and energy stores in the body. Evidence is now rapidly growing that particular lipid species are also important for molecular and cellular signaling. Here we review the current information on interactions between lipids and transient receptor potential (TRP) ion channels in nociceptive sensory afferents that mediate pain signaling. Sensory neuronal TRP channels play a crucial role in the detection of a variety of external and internal changes, particularly with damaging or pain-eliciting potentials that include noxiously high or low temperatures, stretching, and harmful substances. In addition, recent findings suggest that TRPs also contribute to altering synaptic plasticity that deteriorates chronic pain states. In both of these processes, specific lipids are often generated and have been found to strongly modulate TRP activities, resulting primarily in pain exacerbation. This review summarizes three standpoints viewing those lipid functions for TRP modulations as second messengers, intercellular transmitters, or bilayer building blocks. Based on these hypotheses, we discuss perspectives that account for how the TRP-lipid interaction contributes to the peripheral pain mechanism. Still a number of blurred aspects remain to be examined, which will be answered by future efforts and may help to better control pain states.
authors.affiliation: Department of Biomedical Sciences, Korea University College of Medicine, Seoul 136-705, Korea. headyoo@korea.ac.kr.
authors.forename: Sungjae
authors.initials: S
authors.lastname: Yoo
authors.affiliation: Department of Biomedical Sciences, Korea University College of Medicine, Seoul 136-705, Korea. ljyangel1004@korea.ac.kr.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Lim
authors.affiliation: Department of Biomedical Sciences, Korea University College of Medicine, Seoul 136-705, Korea. sunhwang@korea.ac.kr.
authors.forename: Sun Wook
authors.initials: SW
authors.lastname: Hwang
mesh_terms: D000818:Animals; D015870:Gene Expression; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D008055:Lipids / Q000502:physiology*; D009473:Neuronal Plasticity; D059225:Nociception / Q000502:physiology*; D010146:Pain / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction; D050051:Transient Receptor Potential Channels / Q000145:classification / Q000235:genetics / Q000378:metabolism*
chemical_list: D008055:Lipids; D050051:Transient Receptor Potential Channels
references.citation: Support Care Cancer. 2008 Oct;16(10):1105-15
references.pmid: 18682990
references.citation: Anal Biochem. 2008 Dec 1;383(1):18-24
references.pmid: 18782552
references.citation: Chem Res Toxicol. 2007 Jul;20(7):1008-18
references.pmid: 17550273
references.citation: J Biol Chem. 2005 Nov 18;280(46):38496-504
references.pmid: 16081411
references.citation: Neuron. 2008 Mar 13;57(5):746-59
references.pmid: 18341994
references.citation: J Neurosci. 2011 Aug 10;31(32):11425-36
references.pmid: 21832173
references.citation: Pflugers Arch. 2012 Apr;463(4):549-59
references.pmid: 22222967
references.citation: Circ Res. 2003 Oct 31;93(9):829-38
references.pmid: 14512441
references.citation: Nature. 1999 Jan 21;397(6716):255-9
references.pmid: 9930700
references.citation: Cell. 2006 Mar 24;124(6):1269-82
references.pmid: 16564016
references.citation: Cell. 2002 Mar 8;108(5):705-15
references.pmid: 11893340
references.citation: Nature. 2013 Dec 5;504(7478):113-8
references.pmid: 24305161
references.citation: Nat Cell Biol. 2000 Oct;2(10):695-702
references.pmid: 11025659
references.citation: Biochim Biophys Acta. 2009 Mar;1793(3):528-39
references.pmid: 19321128
references.citation: Gastroenterology. 2008 Sep;135(3):937-46, 946.e1-2
references.pmid: 18565335
references.citation: J Gen Physiol. 2009 Mar;133(3):257-62
references.pmid: 19237591
references.citation: Nature. 1999 Jul 29;400(6743):452-7
references.pmid: 10440374
references.citation: J Neurosci. 2007 Mar 21;27(12):3347-55
references.pmid: 17376995
references.citation: Nature. 2003 Jul 24;424(6947):434-8
references.pmid: 12879072
references.citation: Cell. 2003 Mar 21;112(6):819-29
references.pmid: 12654248
references.citation: EMBO J. 2005 Sep 7;24(17):3026-37
references.pmid: 16107881
references.citation: Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10150-5
references.pmid: 12097645
references.citation: Neuroscience. 2000;100(4):685-8
references.pmid: 11036202
references.citation: Nature. 1999 Sep 30;401(6752):493-7
references.pmid: 10519554
references.citation: Nature. 2007 Jul 12;448(7150):204-8
references.pmid: 17538622
references.citation: Cell. 2010 Apr 16;141(2):331-43
references.pmid: 20403327
references.citation: Eur J Neurosci. 2006 Jul;24(1):1-6
references.pmid: 16800863
references.citation: Circ Res. 2005 Oct 28;97(9):908-15
references.pmid: 16179585
references.citation: Mol Pharmacol. 2008 Feb;73(2):274-81
references.pmid: 18000030
references.citation: Brain Res. 2000 Apr 17;862(1-2):217-29
references.pmid: 10799688
references.citation: Anal Biochem. 1988 Sep;173(2):321-7
references.pmid: 3189812
references.citation: Nat Med. 2010 Dec;16(12):1396-9
references.pmid: 21076394
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12045-50
references.pmid: 18687886
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18820-4
references.pmid: 19843694
references.citation: J Neurosci. 2004 Apr 7;24(14):3663-71
references.pmid: 15071115
references.citation: Nat Neurosci. 2010 Dec;13(12):1511-8
references.pmid: 21076423
references.citation: Mol Pain. 2010 Jan 21;6:4
references.pmid: 20092626
references.citation: Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10246-51
references.pmid: 17548815
references.citation: Eur J Pharmacol. 1998 Apr 3;346(1):51-3
references.pmid: 9617751
references.citation: J Biol Chem. 2006 Dec 29;281(52):40174-82
references.pmid: 17082190
references.citation: Mol Pharmacol. 2009 Jun;75(6):1262-79
references.pmid: 19297520
references.citation: Mol Pain. 2008 Jul 31;4:30
references.pmid: 18671867
references.citation: Nat Neurosci. 2006 May;9(5):628-35
references.pmid: 16617338
references.citation: Neurosci Lett. 2007 Sep 25;425(2):120-5
references.pmid: 17850966
references.citation: Pain. 2005 Dec 15;119(1-3):225-232
references.pmid: 16298071
references.citation: J Neurosci. 2011 Dec 14;31(50):18433-8
references.pmid: 22171045
references.citation: J Clin Invest. 2005 Sep;115(9):2393-401
references.pmid: 16110328
references.citation: Curr Opin Neurobiol. 2005 Jun;15(3):370-8
references.pmid: 15922587
references.citation: J Neurosci. 2007 Dec 12;27(50):13680-90
references.pmid: 18077679
references.citation: J Dent Res. 2010 Oct;89(10):1154-9
references.pmid: 20651096
references.citation: Surg Forum. 1970;21:227-8
references.pmid: 5514733
references.citation: Br J Pharmacol. 2012 Jun;166(4):1433-43
references.pmid: 22300296
references.citation: Neuron. 1989 Oct;3(4):497-505
references.pmid: 2642008
references.citation: Neuroreport. 2003 Dec 2;14(17):2251-5
references.pmid: 14625457
references.citation: J Gen Physiol. 2000 Mar;115(3):287-304
references.pmid: 10694258
references.citation: Neuroreport. 2005 Nov 7;16(16):1735-9
references.pmid: 16237318
references.citation: J Biol Chem. 2010 Jun 18;285(25):19362-71
references.pmid: 20395302
references.citation: J Cell Physiol. 2006 Jul;208(1):201-12
references.pmid: 16557504
references.citation: Cell Rep. 2014 Jan 16;6(1):70-80
references.pmid: 24388754
references.citation: PLoS One. 2012;7(6):e38439
references.pmid: 22723860
references.citation: Neuropharmacology. 2001 Dec;41(8):1000-5
references.pmid: 11747904
references.citation: Nature. 1989 Nov 30;342(6249):553-5
references.pmid: 2511450
references.citation: Nature. 2002 Jul 11;418(6894):181-6
references.pmid: 12077604
references.citation: Anal Biochem. 1997 Oct 1;252(1):89-95
references.pmid: 9324945
references.citation: Curr Opin Anaesthesiol. 2006 Oct;19(5):566-72
references.pmid: 16960493
references.citation: J Neurosci. 2010 Nov 10;30(45):15165-74
references.pmid: 21068322
references.citation: J Neurosci. 2008 Dec 17;28(51):13727-37
references.pmid: 19091963
references.citation: Nat Neurosci. 2012 Jul 26;15(8):1063-7
references.pmid: 22837035
references.citation: Anal Biochem. 2001 May 15;292(2):272-9
references.pmid: 11355861
references.citation: Gastroenterology. 2008 Jun;134(7):2059-69
references.pmid: 18343379
references.citation: Nature. 1983 Feb 17-23;301(5901):621-3
references.pmid: 6828143
references.citation: Pain. 2011 Jul;152(7):1459-1468
references.pmid: 21489690
references.citation: J Pain. 2008 Apr;9(4):298-308
references.pmid: 18226966
references.citation: Eur J Pharmacol. 2006 Dec 28;553(1-3):1-9
references.pmid: 17081515
references.citation: J Neurosci. 2010 Oct 6;30(40):13338-47
references.pmid: 20926660
references.citation: Biochem J. 2000 Nov 1;351 Pt 3:817-24
references.pmid: 11042139
references.citation: Br J Pharmacol. 2007 Jun;151(4):530-40
references.pmid: 17420775
references.citation: FASEB J. 2012 Apr;26(4):1755-65
references.pmid: 22253477
references.citation: Chem Res Toxicol. 2000 Aug;13(8):698-702
references.pmid: 10956056
references.citation: J R Soc Interface. 2010 Jun 6;7 Suppl 3:S307-20
references.pmid: 20356872
references.citation: J Gen Physiol. 2006 Nov;128(5):509-22
references.pmid: 17074976
references.citation: J Neurosci. 2008 Mar 5;28(10):2485-94
references.pmid: 18322093
references.citation: Circ Res. 2006 Jul 21;99(2):119-31
references.pmid: 16857972
references.citation: Eur J Neurosci. 2005 Aug;22(4):825-34
references.pmid: 16115206
references.citation: BMC Neurol. 2007 May 23;7:11
references.pmid: 17521436
references.citation: Pain. 2005 Aug;116(3):194-204
references.pmid: 15927395
references.citation: Neuron. 2004 Mar 25;41(6):849-57
references.pmid: 15046718
references.citation: Mol Pain. 2007 Dec 17;3:40
references.pmid: 18086313
references.citation: Proc Natl Acad Sci U S A. 1990 Sep;87(18):7334-8
references.pmid: 1698296
references.citation: Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8400-5
references.pmid: 12060783
references.citation: FEBS Lett. 2000 Nov 24;485(2-3):127-34
references.pmid: 11094154
references.citation: J Neurosci. 2009 Aug 12;29(32):10000-9
references.pmid: 19675234
references.citation: Cell. 2000 Oct 27;103(3):525-35
references.pmid: 11081638
references.citation: Neuron. 2006 Apr 20;50(2):277-89
references.pmid: 16630838
references.citation: Pharmacol Ther. 2007 Apr;114(1):13-33
references.pmid: 17349697
references.citation: J Invest Dermatol. 2009 Mar;129(3):714-22
references.pmid: 18754035
references.citation: Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19564-8
references.pmid: 17164327
references.citation: J Biol Chem. 2011 Jul 15;286(28):24966-76
references.pmid: 21555515
references.citation: Cell. 2009 Oct 16;139(2):267-84
references.pmid: 19837031
references.citation: Curr Neuropharmacol. 2013 Dec;11(6):664-76
references.pmid: 24396341
references.citation: Nature. 2000 May 11;405(6783):183-7
references.pmid: 10821274
references.citation: J Membr Biol. 1987;95(2):113-20
references.pmid: 3573030
references.citation: Ann N Y Acad Sci. 2007 Nov;1117:209-57
references.pmid: 18056045
references.citation: Neuron. 1998 Sep;21(3):531-43
references.pmid: 9768840
references.citation: Exp Cell Res. 2007 May 15;313(9):1911-20
references.pmid: 17428469
references.citation: J Physiol. 2007 Feb 1;578(Pt 3):715-33
references.pmid: 17124270
references.citation: J Biol Chem. 2003 Apr 18;278(16):13633-9
references.pmid: 12569099
references.citation: Nat Neurosci. 2010 Dec;13(12):1519-25
references.pmid: 21076424
references.citation: J Clin Invest. 2013 Sep;123(9):3941-51
references.pmid: 23925292
references.citation: Am J Physiol. 1996 Jan;270(1 Pt 2):R228-37
references.pmid: 8769806
references.citation: Mol Pain. 2007 Oct 29;3:31
references.pmid: 17967183
references.citation: J Neurosci. 2012 May 2;32(18):6364-72
references.pmid: 22553041
references.citation: Neurosci Lett. 2008 Feb 27;432(3):222-7
references.pmid: 18206306
references.citation: J Biol Chem. 2002 Apr 19;277(16):13569-77
references.pmid: 11827975
references.citation: Exp Neurol. 2011 Nov;232(1):90-9
references.pmid: 21867704
references.citation: J Neurosci. 2007 Oct 31;27(44):12067-77
references.pmid: 17978048
references.citation: Nature. 1997 Oct 23;389(6653):816-24
references.pmid: 9349813
references.citation: Acta Physiol Scand. 2001 Sep;173(1):113-8
references.pmid: 11678733
references.citation: Am J Physiol Cell Physiol. 2008 Jul;295(1):C92-9
references.pmid: 18495815
references.citation: J Neurosci. 2011 Oct 19;31(42):15072-85
references.pmid: 22016541
references.citation: Biochim Biophys Acta. 2004 Nov 3;1666(1-2):275-88
references.pmid: 15519321
references.citation: J Med Chem. 2010 Jul 22;53(14):5085-107
references.pmid: 20356305
references.citation: J Neurosci. 2007 Oct 17;27(42):11412-5
references.pmid: 17942735
references.citation: J Clin Invest. 2010 May;120(5):1617-26
references.pmid: 20424317
references.citation: Hippocampus. 2012 Feb;22(2):209-21
references.pmid: 21069781
references.citation: J Neurosci. 2006 May 3;26(18):4835-40
references.pmid: 16672657
references.citation: Expert Opin Ther Targets. 2009 Jan;13(1):69-81
references.pmid: 19063707
references.citation: Nature. 2001 Jun 21;411(6840):957-62
references.pmid: 11418861
references.citation: Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):E1578-86
references.pmid: 22586118
references.citation: J Neurosci. 2007 Jun 27;27(26):7070-80
references.pmid: 17596456
references.citation: Science. 2005 Mar 4;307(5714):1468-72
references.pmid: 15746429
references.citation: J Cell Biol. 2003 Jun 9;161(5):957-67
references.pmid: 12796481
references.citation: Nature. 1989 Feb 9;337(6207):557-60
references.pmid: 2492640
references.citation: Eur J Neurosci. 2002 Oct;16(8):1483-9
references.pmid: 12405961
references.citation: Gut. 2010 Apr;59(4):481-8
references.pmid: 20332520
references.citation: Mol Pain. 2009 Apr 21;5:19
references.pmid: 19383149
references.citation: Mol Pain. 2013 Jan 02;9:1
references.pmid: 23279936
references.citation: J Neurochem. 2010 Dec;115(6):1530-42
references.pmid: 20950340
references.citation: J Biol Chem. 1982 Jul 10;257(13):7847-51
references.pmid: 7085651
references.citation: Proc Natl Acad Sci U S A. 1990 Aug;87(15):5706-9
references.pmid: 1696009
references.citation: Circ Res. 1996 Mar;78(3):415-23
references.pmid: 8593700
references.citation: Neuroscience. 1999;88(4):995-7
references.pmid: 10336113
references.citation: Nature. 2005 Aug 4;436(7051):647-54
references.pmid: 16079835
references.citation: J Neurosci. 2010 Mar 31;30(13):4601-12
references.pmid: 20357111
references.citation: Eur J Immunol. 1995 Jul;25(7):2052-8
references.pmid: 7621879
references.citation: Pain. 2007 May;129(1-2):210-23
references.pmid: 17335973
references.citation: Pain. 2010 Aug;150(2):340-350
references.pmid: 20542379
references.citation: J Biol Chem. 2004 Aug 20;279(34):35133-8
references.pmid: 15187078
references.citation: Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E672-8
references.pmid: 11832372
references.citation: Nature. 2007 Feb 1;445(7127):541-5
references.pmid: 17237762
references.citation: Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3542-6
references.pmid: 8622972
references.citation: Br J Pharmacol. 2004 Aug;142(8):1354-60
references.pmid: 15277315
references.citation: Curr Biol. 2006 Aug 22;16(16):1591-605
references.pmid: 16920620
references.citation: Mol Cell. 2002 Jan;9(1):163-73
references.pmid: 11804595
references.citation: Nat Med. 2010 May;16(5):592-7, 1p following 597
references.pmid: 20383154
references.citation: J Biol Chem. 2009 Apr 3;284(14):9215-24
references.pmid: 19176480
references.citation: Nature. 2002 Jul 11;418(6894):186-90
references.pmid: 12077606
references.citation: Nature. 2013 Dec 5;504(7478):107-12
references.pmid: 24305160
references.citation: J Neurosci. 2004 May 5;24(18):4444-52
references.pmid: 15128858
references.citation: J Neurosci. 2005 Feb 16;25(7):1674-81
references.pmid: 15716403
references.citation: J Neurosci. 2007 Mar 7;27(10):2693-703
references.pmid: 17344407
references.citation: Nature. 1989 Feb 9;337(6207):555-7
references.pmid: 2492639
references.citation: J Pharmacol Exp Ther. 2010 Jun;333(3):883-95
references.pmid: 20304940
references.citation: J Am Soc Nephrol. 2004 May;15(5):1244-53
references.pmid: 15100364
references.citation: Neuron. 2007 May 3;54(3):371-8
references.pmid: 17481391
references.citation: Arch Pharm Res. 2013 Jul;36(7):783-91
references.pmid: 23558672
references.citation: J Lipid Res. 2009 Jun;50(6):1015-38
references.pmid: 19244215
references.citation: Nature. 2002 Mar 7;416(6876):52-8
references.pmid: 11882888
references.citation: J Physiol. 2008 Jul 15;586(14):3447-59
references.pmid: 18499726
references.citation: Nature. 1999 Apr 1;398(6726):436-41
references.pmid: 10201375
references.citation: Pain. 2013 Nov;154(11):2441-2451
references.pmid: 23886520
references.citation: PLoS One. 2011;6(7):e22246
references.pmid: 21779403
references.citation: J Neurosci. 2006 Apr 5;26(14):3864-74
references.pmid: 16597741
references.citation: Neuroscience. 2000;101(3):719-25
references.pmid: 11113320
references.citation: Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19492-7
references.pmid: 22109551
references.citation: Proc Natl Acad Sci U S A. 2000 May 23;97(11):6155-60
references.pmid: 10823958
references.citation: Chem Res Toxicol. 2005 Aug;18(8):1219-31
references.pmid: 16097795
references.citation: Nat Rev Immunol. 2008 May;8(5):349-61
references.pmid: 18437155
references.citation: Curr Opin Cell Biol. 2001 Aug;13(4):422-8
references.pmid: 11454447
references.citation: Am J Physiol Cell Physiol. 2013 Oct 1;305(7):C704-15
references.pmid: 23739180
references.citation: Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1273-8
references.pmid: 19144922
references.citation: Mol Pain. 2008 Oct 01;4:42
references.pmid: 18826653
references.citation: Science. 2000 Apr 14;288(5464):306-13
references.pmid: 10764638
references.citation: Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8742-6
references.pmid: 8378358
references.citation: Neuron. 2007 May 3;54(3):379-86
references.pmid: 17481392
references.citation: PLoS One. 2013;8(3):e59593
references.pmid: 23555720
references.citation: Curr Top Med Chem. 2011;11(17):2210-5
references.pmid: 21671874
references.citation: Life Sci. 1995;57(8):785-9
references.pmid: 7637552
references.citation: Nature. 1987 Jul 2-8;328(6125):38-43
references.pmid: 2439918
references.citation: Science. 2002 Jun 14;296(5575):2046-9
references.pmid: 12016205
references.citation: Mol Cells. 2009 Apr 30;27(4):417-22
references.pmid: 19390822
references.citation: Biochim Biophys Acta. 2007 Aug;1772(8):989-1003
references.pmid: 17321113
references.citation: Pain. 2011 May;152(5):1165-1172
references.pmid: 21402443
references.citation: J Biol Chem. 2009 Jan 16;284(3):1570-82
references.pmid: 19019830
references.citation: J Biol Chem. 1980 Mar 25;255(6):2273-6
references.pmid: 7358670
references.citation: Science. 2003 May 23;300(5623):1284-8
references.pmid: 12764195
references.citation: Curr Neuropharmacol. 2013 Dec;11(6):598-605
references.pmid: 24396336
references.citation: Free Radic Biol Med. 1991;11(1):81-128
references.pmid: 1937131
references.citation: Curr Opin Pharmacol. 2002 Jun;2(3):235-42
references.pmid: 12020463
references.citation: J Clin Invest. 2007 Jul;117(7):1979-87
references.pmid: 17571167
references.citation: Nat Commun. 2011 Jun 28;2:369
references.pmid: 21712817
references.citation: PLoS One. 2008 May 07;3(5):e2082
references.pmid: 18461159
references.citation: Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13519-24
references.pmid: 17684094
references.citation: Mol Pharmacol. 2009 Apr;75(4):820-9
references.pmid: 19171673
references.citation: PLoS One. 2009 Oct 29;4(10):e7596
references.pmid: 19893614
references.citation: FASEB J. 2008 Aug;22(8):3024-34
references.pmid: 18492727
references.citation: Biochem J. 2007 Aug 1;405(3):379-95
references.pmid: 17623009
references.citation: Biofactors. 2006;27(1-4):195-202
references.pmid: 17012775
references.citation: Mol Pain. 2005 Jan 17;1:3
references.pmid: 15813989
references.citation: Hypertension. 1999 Jun;33(6):1441-6
references.pmid: 10373230
references.citation: Nature. 1995 May 11;375(6527):155-8
references.pmid: 7753173
references.citation: Mol Pain. 2011 May 17;7:37
references.pmid: 21586160
references.citation: Science. 1989 Jun 9;244(4909):1176-9
references.pmid: 2471269
references.citation: J Biol Chem. 2013 Feb 22;288(8):5790-802
references.pmid: 23288842
references.citation: Eur J Neurosci. 2014 Feb;39(3):409-18
references.pmid: 24494681
references.citation: Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6721-6
references.pmid: 22493235
references.citation: Neuroreport. 2001 Dec 4;12(17):3693-5
references.pmid: 11726776
references.citation: Br J Pharmacol. 2010 Oct;161(3):707-20
references.pmid: 20880407
references.citation: Mol Cell Neurosci. 2006 Aug;32(4):335-43
references.pmid: 16829128
references.citation: Chem Res Toxicol. 2002 Nov;15(11):1445-50
references.pmid: 12437335
references.citation: J Invest Dermatol. 2006 Dec;126(12):2664-72
references.pmid: 16858425
references.citation: J Physiol. 1984 Sep;354:407-18
references.pmid: 6090652
references.citation: J Gen Physiol. 2009 Mar;133(3):245-9
references.pmid: 19237589
references.citation: Nat Neurosci. 2005 May;8(5):626-34
references.pmid: 15852009
references.citation: EMBO J. 1998 Jun 15;17(12):3297-308
references.pmid: 9628867
references.citation: J Neurosci. 2005 May 11;25(19):4835-43
references.pmid: 15888659
references.citation: Curr Neuropharmacol. 2013 Dec;11(6):652-63
references.pmid: 24396340
references.citation: Trends Neurosci. 2011 Nov;34(11):599-609
references.pmid: 21963090
references.citation: J Biol Chem. 2011 Mar 18;286(11):9849-55
references.pmid: 21245133
references.citation: Br J Pharmacol. 2012 Feb;165(3):683-92
references.pmid: 21718307
references.citation: J Physiol. 2007 Aug 1;582(Pt 3):939-44
references.pmid: 17395625
references.citation: Pain. 2011 May;152(5):1156-1164
references.pmid: 21353389
references.citation: PLoS One. 2007 Sep 05;2(9):e827
references.pmid: 17786199
references.citation: J Neurosci. 2004 Jul 14;24(28):6410-5
references.pmid: 15254097
references.citation: J Neurosci. 2005 Feb 2;25(5):1304-10
references.pmid: 15689568