title: Tahyna virus infection, a neglected arboviral disease in the Qinghai-Tibet Plateau of China.
abstract: Tahyna virus (TAHV) was first isolated from mosquitoes collected in the suburbs of Geermu city in the Qinghai-Tibet Plateau of China in 2007. Since then, TAHV antibodies have been detected in local livestock in Geermu, Qinghai. To determine whether the disease caused by TAHV was present in local residents, an investigation was conducted in the summer of 2009. During this investigation, ward inspections were conducted in rural clinics, and clinical information and specimens were collected from patients who complained mainly of acute fever. The collected samples were tested by serological and molecular methods. The results showed that four samples were positive for TAHV immunoglobulin M and had four-fold or higher levels of TAHV-neutralizing antibody titers between convalescent-phase and acute-phase, and that TAHV nucleotide sequences were detected in two acute sera. Clinical features of TAHV infection commonly included fever, accounting for 100%. Among all other symptoms, the one with the highest frequency was pharyngitis (80%), followed by malaise, inappetence, arthralgia, headache, and drowsiness. Follow-up surveys revealed that all cases recovered in 2-5 days after onset, and no serious or deadly cases were observed. This is the first time that the disease caused by TAHV infection has been reported in China. TAHV infection is another known mosquito-borne arboviral disease in China.
authors.affiliation: 1 State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Institute for Viral Disease Control and Prevention , China CDC, Changping District, Beijing, P.R. China .
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Li
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Cao
authors.forename: Shihong
authors.initials: S
authors.lastname: Fu
authors.forename: Jinglin
authors.initials: J
authors.lastname: Wang
authors.forename: Minghua
authors.initials: M
authors.lastname: Li
authors.forename: Suangying
authors.initials: S
authors.lastname: Jiang
authors.forename: Xuewen
authors.initials: X
authors.lastname: Wang
authors.forename: Shiyou
authors.initials: S
authors.lastname: Xing
authors.forename: Linghui
authors.initials: L
authors.lastname: Feng
authors.forename: Zhiqun
authors.initials: Z
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Shencang
authors.initials: S
authors.lastname: Zhao
authors.forename: Huanyu
authors.initials: H
authors.lastname: Wang
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Wang
authors.forename: Guodong
authors.initials: G
authors.lastname: Liang
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D001483:Base Sequence; D002648:Child; D003625:Data Collection; D002141:Encephalitis Virus, California / Q000235:genetics / Q000302:isolation & purification*; D004670:Encephalitis, California / Q000453:epidemiology* / Q000821:virology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D005843:Geography; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D010802:Phylogeny; D017423:Sequence Analysis, RNA; D018609:Tibet / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M
references.citation: Cesk Epidemiol Mikrobiol Imunol. 1966 Jan;15(1):48-53
references.pmid: 4223877
references.citation: Wien Med Wochenschr. 1969 Nov 8;119(45):765-9
references.pmid: 5311420
references.citation: N Engl J Med. 2009 Jun 11;360(24):2536-43
references.pmid: 19516034
references.citation: Emerg Infect Dis. 2009 Feb;15(2):306-9
references.pmid: 19193280
references.citation: Acta Virol. 1966 Jul;10(4):362-4
references.pmid: 4380517
references.citation: Virol J. 2011 Feb 14;8:68
references.pmid: 21314994
references.citation: Parasitol Res. 2008 Dec;103 Suppl 1:S29-43
references.pmid: 19030884
references.citation: Virol J. 2011 Mar 24;8:135
references.pmid: 21435229
references.citation: Am J Trop Med Hyg. 2010 Apr;82(4):705-11
references.pmid: 20348523
references.citation: Emerg Infect Dis. 2010 Sep;16(9):1498-500
references.pmid: 20735948
references.citation: Trans R Soc Trop Med Hyg. 1987;81(4):693
references.pmid: 3445356
references.citation: J Hyg Epidemiol Microbiol Immunol. 1959;3:264-76
references.pmid: 13796705
references.citation: PLoS Negl Trop Dis. 2010 Apr 27;4(4):e624
references.pmid: 20436960
references.citation: Rev Med Virol. 2012 Sep;22(5):301-22
references.pmid: 22407526
references.citation: Acta Virol. 1973 Jan;17(1):94
references.pmid: 4405402
references.citation: J Vector Ecol. 1999 Jun;24(1):1-39
references.pmid: 10436876
references.citation: Vopr Virusol. 2003 Jan-Feb;48(1):45-6
references.pmid: 12608063
references.citation: Vector Borne Zoonotic Dis. 2011 Dec;11(12):1577-81
references.pmid: 21867416
references.citation: Epidemiol Mikrobiol Imunol. 2004 Aug;53(3):112-20
references.pmid: 15524269
references.citation: Acta Virol. 1975 Sep;19(5):447
references.pmid: 241253