title: (E)3-2-(1-(2,4-Dihydroxyphenyl)ethyldeneamino)phenyl)-2-methylquinazoline-4(3H)-one Schiff Base and Its Metal Complexes: A New Drug of Choice against Methicillin-Resistant Staphylococcus aureus.
abstract: The 3-(2-aminophenyl) quinazolin-2-methyl-4(3H)-one and 2,4-dihydroxyacetophenone undergo condensation to afford (E)3-2-(1-(2,4-dihydroxyphenyl)ethyldeneamino)phenyl)-2-methylquinazoline-4(3H)-one Schiff base (DHPEAPMQ). The newly synthesized Schiff base (DHPEAPMQ) and its metal complexes were evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from the Gulbarga region in India. The Cu(II), Ni(II), and Zn(II) complexes of Schiff base (DHPEAPMQ) showed good antimicrobial activity. So, this could be a new drug of choice.
authors.affiliation: Department of Post-Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga, Karnataka 585106, India.
authors.forename: K
authors.initials: K
authors.lastname: Siddappa
authors.affiliation: Department of Post-Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga, Karnataka 585106, India.
authors.forename: Sunilkumar B
authors.initials: SB
authors.lastname: Mane
authors.affiliation: Department of Microbiology, Gulbarga University, Gulbarga, Karnataka 585106, India.
authors.forename: Deene
authors.initials: D
authors.lastname: Manikprabhu
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