title: Exhaled carbon monoxide in adolescents with diabetic cardiovascular autonomic neuropathy.
abstract: The aim of the study was to determine if cardiovascular autonomic neuropathy (CAN) is associated with changed concentration of exhaled carbon monoxide (eCO) in adolescents with type 1 diabetes (T1D). A total of 46 T1D patients and 25 healthy controls (15-19 years) were enrolled. The parameters eCO and carboxyhemoglobin (HbCO) were established using a MICRO-4 Smokerlyser. CAN was examined by standard cardiovascular tests. Adolescents with T1D did not significantly differ in eCO compared to healthy subjects. eCO and HbCO were significantly lower in CAN-positive subjects (n=19) (1.36 ± 1.65 ppm vs. 3.09 ± 2.31, p=0.01 and 0.58 ± 0.49% vs. 1.04 ± 0.44, p<0.01, respectively) compared to CAN-negative subjects (n=27), whereas no significant difference was found in other measured parameters. By multivariate logistic regression, eCO and HbCO were associated with higher risk of CAN (OR=1.824, p<0.05 and OR=10.989, p<0.01). Our results indicate that eCO is decreased in CAN-positive diabetic subjects. Further studies are necessary to investigate the possible role of eCO as a marker for CAN.
authors.forename: Jarmila
authors.initials: J
authors.lastname: Vojtková
authors.forename: Peter
authors.initials: P
authors.lastname: Ďurdík
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Michnová
authors.forename: Tomáš
authors.initials: T
authors.lastname: Turčan
authors.forename: Miriam
authors.initials: M
authors.lastname: Čiljaková
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D002248:Carbon Monoxide / Q000378:metabolism*; D002263:Carboxyhemoglobin / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D006801:Humans; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin