title: Radiation-induced malignant fibrous histiocytoma of the occipital: a case report.
abstract: Malignant fibrous histiocytoma (MFH) is a rare neoplasm exhibiting a propensity for aggressive clinical behavior. Effective treatment modality is surgical resection with wide margins, but its rate of recurrence and metastasis is still high. Early detection and complete excision of the tumor is necessary. A MFH of the occipital developed in a 51-year-old woman eight years after surgery and radiation for medulloblastoma of the cerebellar vermis. The secondary neoplasm arose at the site of tumor resection within the irradiated field, and was resected. The development of sarcomas is a recognized complication of radiation therapy. The final diagnosis after the operation was MFH. Radiation-induced sarcoma (RIS) is well known, but radiation-induced MFH is relatively rare in the head and neck region, especially in the occipital. The imaging findings are not diagnosis specific, but strict follow-up within the radiation field by computerized tomography (CT) and magnetic resonance imaging (MRI) and appreciation of the expected latency period may help in providing the diagnosis of RIS.
authors.forename: Guo-Bin
authors.initials: GB
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Zhang
authors.forename: Li-Jiang
authors.initials: LJ
authors.lastname: Han
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Tiantan Xili 6, Chongwen District, Beijing 100050, PR China. zjt_ttyy@sina.com.
authors.forename: Jun-Ting
authors.initials: JT
authors.lastname: Zhang
mesh_terms: D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008527:Medulloblastoma / Q000150:complications / Q000532:radiotherapy*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D009777:Occipital Bone / Q000528:radiation effects*; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects*; D012509:Sarcoma / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D014057:Tomography, X-Ray Computed
references.citation: Clin Orthop Relat Res. 2008 Jun;466(6):1292-301
references.pmid: 18437502
references.citation: Br J Oral Maxillofac Surg. 2006 Jun;44(3):209-12
references.pmid: 16026908
references.citation: Cancer. 2001 Jul 1;92(1):172-80
references.pmid: 11443624
references.citation: Arch Pathol Lab Med. 2008 Jun;132(6):1030-5
references.pmid: 18517265
references.citation: Cancer. 1993 Aug 1;72(3):887-93
references.pmid: 8334642
references.citation: Odontology. 2011 Jul;99(2):203-8
references.pmid: 21487703
references.citation: Radiology. 2000 Jul;216(1):197-205
references.pmid: 10887248
references.citation: Cancer. 2005 Aug 15;104(4):856-63
references.pmid: 15981282
references.citation: Am J Otolaryngol. 2001 Jan-Feb;22(1):2-18
references.pmid: 11172210
references.citation: Eur J Cancer. 1998 Dec;34(13):2068-75
references.pmid: 10070313
references.citation: Cancer. 1998 Jan 1;82(1):8-34
references.pmid: 9428476
references.citation: Fam Cancer. 2009;8(3):209-13
references.pmid: 19130300
references.citation: World J Surg Oncol. 2008 Dec 30;6:138
references.pmid: 19116008
references.citation: J Am Acad Dermatol. 2012 Dec;67(6):1335-41
references.pmid: 22677489
references.citation: Neurol Med Chir (Tokyo). 2004 May;44(5):249-54
references.pmid: 15200060
references.citation: Fam Cancer. 2011 Sep;10(3):591-5
references.pmid: 21598002
references.citation: Arch Otolaryngol Head Neck Surg. 1996 May;122(5):535-8
references.pmid: 8615972
references.citation: Cancer. 1971 Nov;28(5):1087-99
references.pmid: 5288429
references.citation: Cancer. 1981 Jan 15;47(2):248-54
references.pmid: 6936069
references.citation: Eur J Surg Oncol. 1994 Feb;20(1):53-6
references.pmid: 8131870
references.citation: J Natl Cancer Inst. 1988 Apr 20;80(4):233-40
references.pmid: 3280809
references.citation: Br J Radiol. 2007 Oct;80(958):790-7
references.pmid: 17908819
references.citation: Head Neck. 2009 Jan;31(1):85-93
references.pmid: 18853446
references.citation: Ann Surg Oncol. 2004 Jun;11(6):619-28
references.pmid: 15172935
references.citation: Cancer. 1996 Aug 15;78(4):912-7
references.pmid: 8756389
references.citation: Cancer Invest. 2001;19(1):23-7
references.pmid: 11291552
references.citation: Diagn Interv Radiol. 2005 Mar;11(1):23-7
references.pmid: 15795839
references.citation: J Clin Neurosci. 2002 Nov;9(6):704-8
references.pmid: 12604291