title: [Correlation of sex hormones and parathyroid hormone with biochemical markers of bone turnover in aged men].
abstract: OBJECTIVE
  To investigate the correlation of serum sex hormones and parathyroid hormone (PTH) with the biochemical markers of bone turnover in aged men.
  
  
  METHODS
  We collected the laboratory data of 465 men aged 60- 93 (73. 1 +/- 8. 3) years old, who came for routine physical examinations in our hospital. We obtained the levels of serum follicle- stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), sex hormone binding globulin (SHBG), PTH, 25-hydroxy-vitamin D3 (25(OH) D3), and bone turnover markers C-terminal telopeptide of type I collagen (CTX), osteocalcin (OC) and amino-terminal propeptide of type I procollagen (PINP). We also determined free testosterone (FT) , bioactive testosterone (BT) , testosterone secretion index (TSI) and FT index (FTI), and analyzed the correlation of each index with the biochemical markers of bone turnover.
  
  
  RESULTS
  The concentrations of serum FSH, LH, and SHBG increased, while the levels of FT, BT, TSI, FTI, PTH, CTX, OC and PINP decreased with age, especially in those over 80 years old (P <0.05). PTH was positively correlated with CTX, OC and PINP (r =0. 227, 0. 269 and 0. 162, P <0. 01), even after the adjustment for age, while SHBG negatively correlated with OC (r = -0. 100, P <0.05). The bone turnover markers increased with the elevation of the PTH quartiles, with significant differences between the first and the fourth quartile (P <0. 01). Multiple stepwise regression analysis showed that age was correlated inversely with CTX, OC and PINP ( beta = -0. 126, -0. 141 and -0. 122, P <0.05) , PTH positively with the three markers (beta = 0. 196, 0.279 and 0.189; P <0. 001), and SHBG negatively with OC ( beta = -0. 100, P <0.05) .
  
  
  CONCLUSIONS
  Aging is the fundamental cause of reduced bone turnover in aged men. The levels serum PTH and SHBG are significantly associated with the biochemical markers of bone turnover.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Xiao
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Lu
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Gong
authors.forename: Yu
authors.initials: Y
authors.lastname: Pei
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Cheng
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Fu-Sheng
authors.initials: FS
authors.lastname: Fang
authors.forename: Hui
authors.initials: H
authors.lastname: Tian
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Li
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism*; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D013739:Testosterone / Q000097:blood
chemical_list: D012739:Gonadal Steroid Hormones; D010281:Parathyroid Hormone; D013739:Testosterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone