title: Noncoding RNAs: emerging players in muscular dystrophies.
abstract: The fascinating world of noncoding RNAs has recently come to light, thanks to the development of powerful sequencing technologies, revealing a variety of RNA molecules playing important regulatory functions in most, if not all, cellular processes. Many noncoding RNAs have been implicated in regulatory networks that are determinant for skeletal muscle differentiation and disease. In this review, we outline the noncoding RNAs involved in physiological mechanisms of myogenesis and those that appear dysregulated in muscle dystrophies, also discussing their potential use as disease biomarkers and therapeutic targets.
authors.affiliation: Institute of Cell Biology and Neurobiology, National Research Council, 00015 Monterotondo Scalo, Italy.
authors.forename: Germana
authors.identifier: 0000-0002-3508-7623
authors.initials: G
authors.lastname: Falcone
authors.affiliation: Policlinico San Donato-IRCCS, Molecular Cardiology Laboratory, 20097 San Donato Milanese, Milan, Italy.
authors.forename: Alessandra
authors.identifier: 0000-0001-9514-9032
authors.initials: A
authors.lastname: Perfetti
authors.affiliation: Institute of Cell Biology and Neurobiology, National Research Council, 00015 Monterotondo Scalo, Italy.
authors.forename: Beatrice
authors.identifier: 0000-0002-3333-3384
authors.initials: B
authors.lastname: Cardinali
authors.affiliation: Policlinico San Donato-IRCCS, Molecular Cardiology Laboratory, 20097 San Donato Milanese, Milan, Italy.
authors.forename: Fabio
authors.identifier: 0000-0002-8624-7738
authors.initials: F
authors.lastname: Martelli
mesh_terms: D000818:Animals; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D009124:Muscle Proteins / Q000235:genetics*; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009136:Muscular Dystrophies / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*
chemical_list: D009124:Muscle Proteins; D022661:RNA, Untranslated
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