title: Prediction of large-for-gestation neonates with first-trimester maternal serum PAPP-A.
abstract: OBJECTIVE
  The aim of this paper was to identify maternal/pregnancy characteristics, first trimester ultrasound parameters and biochemical indices which are significant independent predictors of large-for-gestational age (LGA) neonates.
  
  
  METHODS
  An Observational cross-sectional study was conducted at the Fetal Medicine Unit, Department of Obstetrics and Gynecology of the University of Udine (Italy). Seventy-two singleton pregnancies presenting for screening for chromosomal abnormalities by nuchal translucency and maternal serum biochemistry at 11-14 weeks. Linear regression was applied to develop first trimester prediction models for LGA.
  
  
  RESULTS
  Maternal height, parity, smoking, assisted conception and pregnancy-associated plasma protein-A were significant independent predictors of LGA. PAPP-A cut-off value expressed in MoM of 1.25 used for the study was chosen to obtain good sensitivity and specificity values.
  
  
  CONCLUSIONS
  Prediction for birthweight deviations (LGA) is feasible using data available at the routine 11-14 weeks' examination.
authors.affiliation: Department of Obstetrics and Gynecology, University of Udine, Udine, Italy - irenerom@libero.it.
authors.forename: A
authors.initials: A
authors.lastname: Rossi
authors.forename: E
authors.initials: E
authors.lastname: Vogrig
authors.forename: L
authors.initials: L
authors.lastname: Ganzitti
authors.forename: L
authors.initials: L
authors.lastname: Forzano
authors.forename: G
authors.initials: G
authors.lastname: Simoncini
authors.forename: I
authors.initials: I
authors.lastname: Romanello
authors.forename: G
authors.initials: G
authors.lastname: Ambrosini
authors.forename: D
authors.initials: D
authors.lastname: Marchesoni
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight / Q000502:physiology*; D003430:Cross-Sectional Studies; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D016014:Linear Models; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal / Q000379:methods*; D055815:Young Adult
chemical_list: D011266:Pregnancy-Associated Plasma Protein-A