title: Cross-sectional analysis of obesity and serum analytes in males identifies sRAGE as a novel biomarker inversely associated with diverticulosis.
abstract: Diverticulosis can lead to diverticulitis, a colon condition involving inflammation and other complications. Diverticulosis can result from biological, behavioral, or genetic causes. However, the etiology of diverticulosis is unknown. Although diet is associated with diverticulosis, recent studies suggest other factors influence risk. We sought to identify anthropometric or serum markers that were associated with the presence of diverticulosis. To determine these associations, 126 asymptomatic men (48-65 yr) were recruited at the time of preventative screening colonoscopy. Anthropometric measures were taken, and blood was collected for serum protein analysis. Data were analyzed by logistic regression and factor analysis. Obese individuals (BMI >30) were 7.8 (CI: 2.3-26.3) times more likely than normal weight (BMI <25) individuals to have diverticulosis. The relationship was similar for waist circumference. Individuals with a waist circumference >45 inches were 8.1 (CI: 2.8-23.8) times more likely to have diverticulosis than those with a waist circumference <38 inches. Leptin was also positively associated with diverticulosis (OR = 5.5, CI: 2.0-14.7). Both low molecular weight adiponectin (LMW, OR = 0.50; CI: 0.3-0.8) and the soluble receptor for advanced glycation end products (sRAGE, OR = 0.4, CI: 0.3-0.7) were inversely related to the presence of diverticulosis. sRAGE levels were not correlated with leptin or C-peptide concentrations. The pattern of high BMI, waist circumference, leptin and C-peptide increased the odds of diverticulosis while the pattern of high levels of sRAGE and LMW adiponectin decreased the odds of diverticulosis. Associations between diverticulosis and anthropometric or serum markers may elucidate the origins of diverticulosis and may enable physicians to identify individuals at risk for diverticulitis.
authors.affiliation: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, United States of America.
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Comstock
authors.affiliation: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, United States of America.
authors.forename: Markita M
authors.initials: MM
authors.lastname: Lewis
authors.affiliation: Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, United States of America.
authors.forename: Dorothy R
authors.initials: DR
authors.lastname: Pathak
authors.affiliation: College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America.
authors.forename: Kari
authors.initials: K
authors.lastname: Hortos
authors.affiliation: College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America; Tri-County Gastroenterology, Professional Corporation, Clinton Township, Michigan, United States of America.
authors.forename: Bruce
authors.initials: B
authors.lastname: Kovan
authors.affiliation: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, United States of America; College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America.
authors.forename: Jenifer I
authors.initials: JI
authors.lastname: Fenton
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000886:Anthropometry; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood; D003113:Colonoscopy; D003430:Cross-Sectional Studies; D004240:Diverticulum / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D005163:Factor Analysis, Statistical; D006801:Humans; D020738:Leptin / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D055105:Waist Circumference
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D002096:C-Peptide; D020738:Leptin; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic
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