title: [Association between CISH polymorphisms and susceptibility to chronic hepatitis B in Chinese Han population].
abstract: OBJECTIVE
  To investigate the association between rs414171 single nucleotide polymorphisms (SNP) of cytokine- inducible src homology 2 domain protein (CISH) and the susceptibility to chronic hepatitis B.
  
  
  METHODS
  A total of 233 Chinese Han patients with chronic hepatitis B and 148 age- and sex-matched healthy controls were enrolled in this case-control study. The SNP rs414171 was genotyped by Sequenom MassArray-IPLEX to analyze the relationship between rs414171 and chronic hepatitis B.
  
  
  RESULTS
  The distribution of SNP rs414171 allele and genotype frequencies showed no significant difference between the patients and healthy controls (P>0.05).
  
  
  CONCLUSIONS
  CISH rs414171 is not significantly associated with the susceptibility to chronic hepatitis B in Chinese Han population.
authors.affiliation: Department of Hepatology, Shuguang Hospital Affiliated of Shanghai Traditional Chinese Medicine University, Clinical Key Laboratory of Traditional Chinese Medicine, Shanghai 201203, China.E-mail: zhangxin68619@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Xuehua
authors.initials: X
authors.lastname: Sun
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Zhou
authors.forename: Man
authors.initials: M
authors.lastname: Li
authors.forename: Yueqiu
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics*
chemical_list: D050826:Suppressor of Cytokine Signaling Proteins