title: Merit of ginseng in the treatment of heart failure in type 1-like diabetic rats.
abstract: The present study investigated the merit of ginseng in the improvement of heart failure in diabetic rats and the role of peroxisome proliferator-activated receptors δ (PPAR δ ). We used streptozotocin-induced diabetic rat (STZ-rat) to screen the effects of ginseng on cardiac performance and PPAR δ expression. Changes of body weight, water intake, and food intake were compared in three groups of age-matched rats; the normal control (Wistar rats) received vehicle, STZ-rats received vehicle and ginseng-treated STZ-rats. We also determined cardiac performances in addition to blood glucose level in these animals. The protein levels of PPAR δ in hearts were identified using Western blotting analysis. In STZ-rats, cardiac performances were decreased but the food intake, water intake, and blood glucose were higher than the vehicle-treated control. After a 7-day treatment of ginseng in STZ-rats, cardiac output was markedly enhanced without changes in diabetic parameters. This treatment with ginseng also increased the PPAR δ expression in hearts of STZ-rats. The related signal of cardiac contractility, troponin I phosphorylation, was also raised. Ginseng-induced increasing of cardiac output was reversed by the cotreatment with PPAR δ antagonist GSK0660. Thus, we suggest that ginseng could improve heart failure through the increased PPAR δ expression in STZ-rats.
authors.affiliation: Department of Neurosurgery, Mackay Memorial Hospital, Taipei 104, Taiwan ; Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Cheng-Chia
authors.initials: CC
authors.lastname: Tsai
authors.affiliation: Department of Cardiology, College of Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.
authors.forename: Paul
authors.initials: P
authors.lastname: Chan
authors.affiliation: Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Li-Jen
authors.initials: LJ
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, College of Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Chen Kuei
authors.initials: CK
authors.lastname: Chang
authors.affiliation: Department of Cardiothoracic Surgery, Shanghai East Hospital, Tongji University, Shanghai, China.
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, College of Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Jia-Wei
authors.identifier: 0000-0002-3311-5379
authors.initials: JW
authors.lastname: Lin
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D047494:PPAR delta / Q000378:metabolism*; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D047494:PPAR delta; D010936:Plant Extracts
references.citation: Phytomedicine. 2012 Apr 15;19(6):477-83
references.pmid: 22341690
references.citation: Circ Res. 2002 Apr 5;90(6):649-56
references.pmid: 11934831
references.citation: Circ Res. 1980 Dec;47(6):922-33
references.pmid: 7438339
references.citation: JAMA. 1979 May 11;241(19):2035-8
references.pmid: 430798
references.citation: ScientificWorldJournal. 2012;2012:248320
references.pmid: 22666095
references.citation: Pflugers Arch. 2008 Oct;457(1):37-46
references.pmid: 18421471
references.citation: Sports Med. 1991 Sep;12(3):208-17
references.pmid: 1664541
references.citation: Nature. 1990 Oct 18;347(6294):645-50
references.pmid: 2129546
references.citation: Biochemistry. 2009 Sep 1;48(34):8161-70
references.pmid: 19637843
references.citation: Circ Res. 2004 Feb 6;94(2):146-58
references.pmid: 14764650
references.citation: J Clin Invest. 2006 Mar;116(3):590-7
references.pmid: 16511591
references.citation: Circ Res. 2011 Aug 5;109(4):407-17
references.pmid: 21700928
references.citation: Am J Cardiol. 1974 Jul;34(1):29-34
references.pmid: 4835750
references.citation: Acta Med Scand. 1988;224(1):31-8
references.pmid: 3046232
references.citation: Horm Metab Res. 2013 Nov;45(12):880-6
references.pmid: 23803968
references.citation: Biochem Biophys Res Commun. 2004 Jan 9;313(2):277-86
references.pmid: 14684157
references.citation: Cardiovasc Diabetol. 2006 Dec 04;5:26
references.pmid: 17144912
references.citation: Drugs. 2011 Oct 22;71(15):1989-2008
references.pmid: 21985167
references.citation: J Mol Med (Berl). 2007 Jul;85(7):697-706
references.pmid: 17356846
references.citation: J Ethnopharmacol. 2011 May 17;135(2):287-98
references.pmid: 21396997
references.citation: Nat Med. 2004 Nov;10(11):1245-50
references.pmid: 15475963
references.citation: Evid Based Complement Alternat Med. 2013;2013:817826
references.pmid: 24282438
references.citation: Circ Res. 1981 Dec;49(6):1251-61
references.pmid: 7030513
references.citation: Mol Endocrinol. 2008 Feb;22(2):523-9
references.pmid: 17975020
references.citation: PLoS One. 2013 May 28;8(5):e64229
references.pmid: 23724037
references.citation: Br J Pharmacol. 2011 May;163(2):390-8
references.pmid: 21232041
references.citation: Cardiovasc Res. 2005 Apr 1;66(1):12-21
references.pmid: 15769444
references.citation: Annu Rev Physiol. 2003;65:45-79
references.pmid: 12524460
references.citation: Horm Metab Res. 2010 Aug;42(9):637-42
references.pmid: 20446238
references.citation: Circ Heart Fail. 2011 Jan;4(1):79-88
references.pmid: 20971938
references.citation: Br J Pharmacol. 2001 Nov;134(6):1159-65
references.pmid: 11704635
references.citation: Biomed Res Int. 2014;2014:723084
references.pmid: 24689053
references.citation: J Pharmacol Exp Ther. 2010 May;333(2):465-77
references.pmid: 20176685
references.citation: Circ Res. 2006 Mar 17;98(5):596-605
references.pmid: 16543510
references.citation: Life Sci. 1995;56(19):1577-86
references.pmid: 7723586
references.citation: Am J Physiol Heart Circ Physiol. 2000 Mar;278(3):H769-79
references.pmid: 10710345
references.citation: J Ginseng Res. 2013 Jul;37(3):273-82
references.pmid: 24198652
references.citation: Cardiovasc Res. 2008 Oct 1;80(1):78-87
references.pmid: 18573863
references.citation: J Dermatol. 2006 Oct;33(10):684-91
references.pmid: 17040497
references.citation: Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1489-506
references.pmid: 16751293
references.citation: Cardiovasc Res. 2004 Aug 1;63(2):245-55
references.pmid: 15249182
references.citation: J Ethnopharmacol. 2012 Nov 21;144(2):234-9
references.pmid: 23044195
references.citation: Expert Opin Drug Saf. 2011 Mar;10(2):319-33
references.pmid: 21314442
references.citation: Perspect Biol Med. 2011 Summer;54(3):304-15
references.pmid: 21857123
references.citation: J Mol Cell Cardiol. 2007 Jan;42(1):247-59
references.pmid: 17081561
references.citation: Eur Heart J. 1988 Mar;9(3):259-64
references.pmid: 3383866
references.citation: Biochim Biophys Acta. 1996 Jun 7;1316(2):78-84
references.pmid: 8672554
references.citation: Braz J Med Biol Res. 2004 Dec;37(12):1895-902
references.pmid: 15558197
references.citation: Evid Based Complement Alternat Med. 2013;2013:152798
references.pmid: 24386001
references.citation: Acta Radiol Suppl (Stockholm). 2008 Aug;434:47-52
references.pmid: 19023715
references.citation: Sex Transm Dis. 2012 Dec;39(12):942-8
references.pmid: 23191947