title: Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435 breast cancer cells in vivo.
abstract: The tumor growth inhibition and anti-metastatic effects of peach polyphenolics were investigated in vivo using a xenograft model and MDA-MB-435 breast cancer cells. Results showed that tumor growth and lung metastasis were inhibited in vivo by peach polyphenolics in a dose range of 0.8-1.6 mg/day, and these effects were mediated by inhibition of metalloproteinases gene expression. Modulation of metalloproteinase-2, metalloproteinase-3 and metalloproteinase-13 gene expression may be some of the molecular targets for anti-metastatic activity of peach polyphenolics. Therefore, these compounds may constitute a novel chemopreventive tool to reduce the risk of metastasis in the combination therapy when primary cancer is diagnosed. Conversion to equivalent human intake for future clinical studies using the body surface area normalization method gave a dose of ~370.6 mg/day for a human adult of 60 kg, which can be supplied by consuming two to three peach fruit per day or alternatively using a dietary supplement peach polyphenol extract powder.
authors.affiliation: Department of Horticultural Sciences, Texas A&M University.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Noratto
authors.affiliation: Department of Veterinary Physiology & Pharmacology, Texas A&M University, College Station, TX 77843.
authors.forename: Weston
authors.initials: W
authors.lastname: Porter
authors.affiliation: Department of Horticultural Sciences, Texas A&M University. Electronic address: dbyrne@ag.tamu.edu.
authors.forename: David
authors.initials: D
authors.lastname: Byrne
authors.affiliation: Department of Horticultural Sciences, Texas A&M University. Electronic address: lcisnero@tamu.edu.
authors.forename: Luis
authors.initials: L
authors.lastname: Cisneros-Zevallos
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology / Q000503:physiopathology; D045744:Cell Line, Tumor; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D020782:Matrix Metalloproteinases / Q000096:biosynthesis; D008819:Mice, Nude; D010936:Plant Extracts / Q000494:pharmacology; D059808:Polyphenols / Q000494:pharmacology*; D027861:Prunus / Q000737:chemistry*; D023041:Xenograft Model Antitumor Assays
chemical_list: D010936:Plant Extracts; D059808:Polyphenols; D020782:Matrix Metalloproteinases
keywords: Breast cancer; In-vivo xenograft model; MDA-MB-435; Metastasis; Peach polyphenols