title: Quality of Life and Sexual Health in the Aging of PCa Survivors.
abstract: Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. However, several trials on androgens and PCa are recently focused on urinary continence, quality of life, and sexual function, suggesting a new point of view on the whole endocrinological aspect of PCa. During aging, metabolic syndrome, including diabetes, hypertension, dyslipidemia, and central obesity, can be associated with a chronic, low-grade inflammation of the prostate and with changes in the sex steroid pathways. These factors may affect both the carcinogenesis processes and treatment outcomes of PCa. Any treatment for PCa can have a long-lasting negative impact on quality of life and sexual health, which should be assessed by validated self-reported questionnaires. In particular, sexual health, urinary continence, and bowel function can be worsened after prostatectomy, radiotherapy, or hormone treatment, mostly in the elderly population. In the present review we summarized the current knowledge on the role of hormones, metabolic features, and primary treatments for PCa on the quality of life and sexual health of elderly Pca survivors.
authors.affiliation: Department of Urology, University of Florence, Careggi Hospital, Viale Gramsci 7, 50121 Florence, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Gacci
authors.affiliation: Department of Experimental and Clinical Biomedical Sciences, Section of Clinical Pathophysiology, University of Florence, Italy.
authors.forename: Elisabetta
authors.identifier: 0000-0003-1154-3433
authors.initials: E
authors.lastname: Baldi
authors.affiliation: Department of Experimental and Clinical Biomedical Sciences, Section of Clinical Pathophysiology, University of Florence, Italy.
authors.forename: Lara
authors.initials: L
authors.lastname: Tamburrino
authors.affiliation: Radiotherapy, University Hospital Careggi, University of Florence, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Detti
authors.affiliation: Radiotherapy, University Hospital Careggi, University of Florence, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Livi
authors.affiliation: Department of Urology, Sant'Andrea Hospital, University "La Sapienza", Rome, Italy.
authors.forename: Cosimo
authors.initials: C
authors.lastname: De Nunzio
authors.affiliation: Department of Urology, Sant'Andrea Hospital, University "La Sapienza", Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Tubaro
authors.affiliation: Department of Urology, University Hospital of Larissa, Larissa, Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Gravas
authors.affiliation: Department of Urology, University of Florence, Careggi Hospital, Viale Gramsci 7, 50121 Florence, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Carini
authors.affiliation: Department of Urology, University of Florence, Careggi Hospital, Viale Gramsci 7, 50121 Florence, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Serni
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