title: [Update on current care guideline: sepsis (adults].
abstract: The incidence of severe sepsis and septic shock requiring intensive care in Finnish adult population has increased to 0.60 11000 /y. Despite improved prognosis, hospital mortality related to severe sepsis and septic shock is high 24.1%. Key recommendations include prompt administration of antimicrobial therapy, optimally after blood cultures, quantitative fluid resuscitation and imaging studies to identify possible source of infection. Crystalloids are suitable for fluid resuscitation. Norepinephrine is the first-choice vasopressor in septic shock. Hydrocortisone should be considered only if fluid and vasopressor treatment does not restore hemodynamics.
authors.forename: Esko
authors.initials: E
authors.lastname: Ruokonen
authors.forename: Seppo
authors.initials: S
authors.lastname: Hovilehto
authors.forename: Sari
authors.initials: S
authors.lastname: Karlsson
authors.forename: Pekka
authors.initials: P
authors.lastname: Loisa
authors.forename: Ville
authors.initials: V
authors.lastname: Pettilä
authors.forename: Esa
authors.initials: E
authors.lastname: Rintala
authors.forename: Joonas
authors.initials: J
authors.lastname: Sirola
authors.forename: Ari
authors.initials: A
authors.lastname: Uusaro
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005387:Finland / Q000453:epidemiology; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D015994:Incidence; D009638:Norepinephrine / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012151:Resuscitation / Q000379:methods; D018805:Sepsis / Q000453:epidemiology / Q000628:therapy*; D012772:Shock, Septic / Q000453:epidemiology / Q000628:therapy
chemical_list: D000316:Adrenergic alpha-Agonists; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D006854:Hydrocortisone; D009638:Norepinephrine