title: HDAC signaling in neuronal development and axon regeneration.
abstract: The development and repair of the nervous system requires the coordinated expression of a large number of specific genes. Epigenetic modifications of histones represent an essential principle by which neurons regulate transcriptional responses and adapt to environmental cues. The post-translational modification of histones by chromatin-modifying enzymes histone acetyltransferases (HATs) and histone deacetylases (HDACs) shapes chromatin to adjust transcriptional profiles during neuronal development. Recent observations also point to a critical role for histone acetylation and deacetylation in the response of neurons to injury. While HDACs are mostly known to attenuate transcription through their deacetylase activity and their interaction with co-repressors, these enzymes are also found in the cytoplasm where they display transcription-independent activities by regulating the function of diverse proteins. Here we discuss recent studies that go beyond the traditional use of HDAC inhibitors and have begun to dissect the roles of individual HDAC isoforms in neuronal development and repair after injury.
authors.affiliation: Department of Anatomy and Neurobiology, Washington University in St. Louis, School of Medicine, St. Louis 63110, MO, USA.
authors.forename: Yongcheol
authors.initials: Y
authors.lastname: Cho
authors.affiliation: Department of Anatomy and Neurobiology, Washington University in St. Louis, School of Medicine, St. Louis 63110, MO, USA. Electronic address: cavalli@pcg.wustl.edu.
authors.forename: Valeria
authors.initials: V
authors.lastname: Cavalli
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D001921:Brain / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D055495:Neurogenesis; D009474:Neurons / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D006655:Histone Deacetylases
references.citation: J Neurosci. 2013 Dec 11;33(50):19664-76
references.pmid: 24336730
references.citation: Nat Chem Biol. 2008 Jul;4(7):408-10
references.pmid: 18552832
references.citation: Mol Neurobiol. 2013 Dec;48(3):490-9
references.pmid: 23475611
references.citation: Cold Spring Harb Perspect Biol. 2009 Sep;1(3):a001644
references.pmid: 20066106
references.citation: J Neurochem. 2009 Aug;110(4):1226-40
references.pmid: 19549282
references.citation: Nat Neurosci. 2010 Nov;13(11):1330-7
references.pmid: 20975757
references.citation: Science. 2011 Feb 18;331(6019):928-31
references.pmid: 21273450
references.citation: Nature. 2008 Sep 18;455(7211):411-5
references.pmid: 18754010
references.citation: PLoS One. 2013 Sep 27;8(9):e76016
references.pmid: 24086678
references.citation: Science. 2004 Feb 13;303(5660):1026-30
references.pmid: 14716021
references.citation: Development. 2004 Jun;131(12):2983-95
references.pmid: 15169759
references.citation: J Biol Chem. 2010 Mar 5;285(10):7187-96
references.pmid: 20032463
references.citation: Neuron Glia Biol. 2010 May;6(2):93-107
references.pmid: 20388229
references.citation: J Cell Sci. 2009 Jul 1;122(Pt 13):2274-82
references.pmid: 19509051
references.citation: Cell. 2013 Nov 7;155(4):894-908
references.pmid: 24209626
references.citation: Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16659-64
references.pmid: 15537713
references.citation: J Cell Biol. 2008 Mar 10;180(5):915-29
references.pmid: 18332217
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17335-40
references.pmid: 17956988
references.citation: Exp Neurol. 2012 Feb;233(2):783-90
references.pmid: 22178331
references.citation: J Neurochem. 2011 Apr;117(1):48-60
references.pmid: 21210813
references.citation: BMC Neurosci. 2010 May 26;11:62
references.pmid: 20504333
references.citation: BMC Genomics. 2011 Jan 12;12:24
references.pmid: 21226904
references.citation: Nat Rev Genet. 2013 May;14(5):347-59
references.pmid: 23568486
references.citation: PLoS One. 2011;6(6):e21056
references.pmid: 21695276
references.citation: EMBO J. 2012 Jun 12;31(14):3063-78
references.pmid: 22692128
references.citation: Mol Cell. 2002 Jan;9(1):45-57
references.pmid: 11804585
references.citation: J Neurosci. 2010 Jul 21;30(29):9939-46
references.pmid: 20660276
references.citation: Nature. 2010 Jun 10;465(7299):728-35
references.pmid: 20535202
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19599-604
references.pmid: 19884510
references.citation: J Mol Biol. 2004 Apr 16;338(1):17-31
references.pmid: 15050820
references.citation: Invest Ophthalmol Vis Sci. 2010 Jan;51(1):526-34
references.pmid: 19628741
references.citation: J Neurosci. 2007 Aug 22;27(34):9169-80
references.pmid: 17715353
references.citation: PLoS Biol. 2013 Nov;11(11):e1001717
references.pmid: 24302884
references.citation: Eur J Neurosci. 2010 May;31(9):1521-32
references.pmid: 20525066
references.citation: Neuron. 2005 Mar 3;45(5):715-26
references.pmid: 15748847
references.citation: Nat Rev Mol Cell Biol. 2008 Mar;9(3):206-18
references.pmid: 18292778
references.citation: Mol Cell Biol. 2005 Jan;25(2):751-66
references.pmid: 15632075
references.citation: PLoS One. 2013 Aug 06;8(8):e71252
references.pmid: 23940731
references.citation: J Cell Biol. 2008 Feb 11;180(3):619-32
references.pmid: 18268107
references.citation: Nat Neurosci. 2012 Dec;15(12):1627-35
references.pmid: 23160044
references.citation: Int J Dev Neurosci. 2013 Oct;31(6):434-47
references.pmid: 23542004
references.citation: Cell. 2007 Jun 29;129(7):1351-63
references.pmid: 17604723
references.citation: Cell. 2009 Jan 23;136(2):322-36
references.pmid: 19167333
references.citation: Nat Rev Neurosci. 2012 Feb 15;13(3):183-93
references.pmid: 22334213
references.citation: Front Cell Neurosci. 2013 Mar 28;7:30
references.pmid: 23543406
references.citation: Mol Biol Cell. 2011 Feb 15;22(4):503-12
references.pmid: 21169561
references.citation: Nat Rev Genet. 2009 Jan;10(1):32-42
references.pmid: 19065135
references.citation: Mol Cell Biol. 2008 Mar;28(5):1688-701
references.pmid: 18180281
references.citation: Genes Dev. 2013 Jul 1;27(13):1473-83
references.pmid: 23796896
references.citation: J Biol Chem. 2013 Nov 15;288(46):33156-70
references.pmid: 24089523
references.citation: Proc Natl Acad Sci U S A. 2009 May 12;106(19):7876-81
references.pmid: 19380719
references.citation: Nat Cell Biol. 2009 Sep;11(9):1057-68
references.pmid: 19668197
references.citation: Stem Cells Dev. 2012 Jan 20;21(2):321-30
references.pmid: 21521032
references.citation: Oncogene. 2009 Jan 22;28(3):445-60
references.pmid: 18850005
references.citation: J Neurosci. 2011 Feb 16;31(7):2688-99
references.pmid: 21325537
references.citation: Neuron. 2011 Mar 10;69(5):840-55
references.pmid: 21382546
references.citation: Exp Brain Res. 2007 Feb;176(4):672-8
references.pmid: 17216146
references.citation: Nat Commun. 2013;4:2532
references.pmid: 24113571
references.citation: Development. 2005 Jul;132(13):3027-43
references.pmid: 15944187
references.citation: Mol Cell. 2007 Jul 20;27(2):197-213
references.pmid: 17643370
references.citation: Cell Death Differ. 2010 Sep;17(9):1392-408
references.pmid: 20094059
references.citation: Neuroscience. 2006 Dec 28;143(4):939-51
references.pmid: 17084985
references.citation: PLoS One. 2008 Jul 16;3(7):e2668
references.pmid: 18628975
references.citation: Nature. 2002 May 23;417(6887):455-8
references.pmid: 12024216
references.citation: J Mol Neurosci. 2007;31(1):47-58
references.pmid: 17416969