title: Meta-analysis of myeloperoxidase gene polymorphism and coronary artery disease susceptibility.
abstract: OBJECTIVE
  To assess the association between myeloperoxidase (MPO) gene polymorphism and coronary artery disease (CAD).
  
  
  METHODS
  Several databases were used to retrieve relevant literature up to March 2013 by keywords. A Meta-analysis was performed by Stata12.0 software to estimate the pooled odds ratio (OR) and the 95% confidence interval (CI). Heterogeneity among studies was tested and sensitivity analysis was applied. Publication bias was examined using Begg's funnel plot and Egger's linear regression test.
  
  
  RESULTS
  A total of 17 studies were included in this Meta-analysis. For MPO -463 G/A polymorphism, the pooled OR of A allele vs G allele was 0.58 [95% CI (0.47-0.72)] and the pooled OR of genotypes AA+AG vs GG was 0.58 [95% CI (0.46-0.72)]. In subgroup analysis of study population, AA and AG genotypes were significantly associated with CAD in Asians but not in Europeans. The MPO -463 G/A polymorphism in the stable angina pectoris subgroup was evaluated in 3 studies and the pooled OR of A allele vs G allele and genotypes AA+AG vs GG for proven CAD was 0.45 [95% CI (0.15-1.37)] and 0.57 [95% CI (0.19- 1.65)]. For MPO -129 A/G gene polymorphism, the pooled OR of genotype GG vs AA+AG was 0.91 [95% CI (0.74-1.10)].
  
  
  CONCLUSIONS
  A allele of MPO -463 G/A gene is associated with decreased risk of CAD except in the Europeans. There is no association between MPO -129 A/G gene polymorphisms and CAD risk.
authors.affiliation: Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Luyao
authors.initials: L
authors.lastname: Chen
authors.forename: Shushan
authors.initials: S
authors.lastname: Zhao
authors.forename: Guangjie
authors.initials: G
authors.lastname: Cheng
authors.forename: Ruizheng
authors.initials: R
authors.lastname: Shi
authors.forename: Guogang
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D044466:Asian People; D003324:Coronary Artery Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D009195:Peroxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People
chemical_list: D009195:Peroxidase