title: TSP1-producing B cells show immune regulatory property and suppress allergy-related mucosal inflammation.
abstract: Specific immunotherapy (SIT) is the only specific remedy for the treatment of allergic diseases currently. B cells are important immune cells in the immunity. The role of B cells in immune regulatory activities has not been fully understood yet. This study aims to elucidate the role of the thrombospondin (TSP)1-producing B cells in the immune regulatory role of SIT. The results showed that after SIT, the frequency of CD35(+) B cells was increased in the intestine of mice with food allergy. The CD35(+) B cells expressed TSP1 after exposure to specific antigens. Co-culture with the TSP1-producing CD35(+) B cells decreased the levels of CD80/CD86 in dendritic cells; the cells convert naïve CD4(+) T cells to regulatory T cells to inhibit allergic inflammation in the intestine.
authors.affiliation: 1] Department of Respirology, the First Hospital, Shanxi Medical University, Taiyuan, China [2].
authors.forename: Huan-Ping
authors.initials: HP
authors.lastname: Zhang
authors.affiliation: 1] Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen, China [2].
authors.forename: Yingying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: ENT Institute of Shenzhen University, Longgang Central Hospital, ENT Hospital, Shenzhen, China.
authors.forename: Jiangqi
authors.initials: J
authors.lastname: Liu
authors.affiliation: ENT Institute of Shenzhen University, Longgang Central Hospital, ENT Hospital, Shenzhen, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.affiliation: ENT Institute of Shenzhen University, Longgang Central Hospital, ENT Hospital, Shenzhen, China.
authors.forename: Xiao-Rui
authors.initials: XR
authors.lastname: Geng
authors.affiliation: ENT Institute of Shenzhen University, Longgang Central Hospital, ENT Hospital, Shenzhen, China.
authors.forename: Gui
authors.initials: G
authors.lastname: Yang
authors.affiliation: Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Mo
authors.affiliation: ENT Institute of Shenzhen University, Longgang Central Hospital, ENT Hospital, Shenzhen, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Liu
authors.affiliation: Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen, China.
authors.forename: Ping-Chang
authors.initials: PC
authors.lastname: Yang
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018122:B7-1 Antigen / Q000378:metabolism; D051940:B7-2 Antigen / Q000378:metabolism; D002772:Cholera Toxin / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D005512:Food Hypersensitivity / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology; D007167:Immunotherapy / Q000379:methods*; D007249:Inflammation / Q000276:immunology; D018793:Interleukin-13 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D015848:Interleukin-5 / Q000378:metabolism; D007422:Intestines / Q000166:cytology / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D017463:Receptors, Complement 3b / Q000096:biosynthesis / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology*; D019700:Thrombospondin 1 / Q000096:biosynthesis* / Q000276:immunology
chemical_list: D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497965:Cd86 protein, mouse; D018793:Interleukin-13; D015848:Interleukin-5; D017463:Receptors, Complement 3b; D019700:Thrombospondin 1; C585483:Thbs1 protein, mouse; D015847:Interleukin-4; D010047:Ovalbumin; D002772:Cholera Toxin
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