title: Interleukin-30: A novel microenvironmental hallmark of prostate cancer progression.
abstract: Metastatic prostate cancer is a leading cause of cancer-related death in men worldwide. We have recently discovered that IL-30 shapes the microenvironment of prostate cancer and tumor-draining lymph nodes to favor tumor progression. IL-30 supports tumor growth in vitro, and IL-30 expression in prostate cancer patients is associated with high tumor grade and metastatic stage of disease. Thus, IL-30 may constitute a valuable target for modern therapeutic approaches to hamper prostate cancer progression.
authors.affiliation: Department of Medicine and Sciences of Aging; Section of Anatomic Pathology and Molecular Medicine; "G. d'Annunzio" University Foundation; Chieti, Italy ; Ce.S.I. Biotech; Aging Research Center; "G. d'Annunzio" University Foundation; Chieti, Italy.
authors.forename: Emma
authors.initials: E
authors.lastname: Di Carlo
keywords: IL-27p28; IL-30; lymph node metastasis; prostate cancer progression; tumor microenvironment; tumor-infiltrating leukocytes
references.citation: Immunity. 2002 Jun;16(6):779-90
references.pmid: 12121660
references.citation: Cytokine Growth Factor Rev. 2011 Oct-Dec;22(5-6):331-8
references.pmid: 22119008
references.citation: Biochem Biophys Res Commun. 2013 May 31;435(2):306-12
references.pmid: 23583238
references.citation: J Biol Chem. 2013 Feb 8;288(6):4346-54
references.pmid: 23209286
references.citation: Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97
references.pmid: 22595692
references.citation: J Pathol. 2000 Jul;191(3):239-44
references.pmid: 10878544
references.citation: Cancer Res. 2009 Jun 15;69(12):5194-201
references.pmid: 19509237
references.citation: Cancer Res. 2007 Apr 15;67(8):3500-4
references.pmid: 17413003
references.citation: Clin Cancer Res. 2009 May 1;15(9):2979-87
references.pmid: 19366834
references.citation: Clin Cancer Res. 2014 Feb 1;20(3):585-94
references.pmid: 24277453