title: Generation and repair of AID-initiated DNA lesions in B lymphocytes.
abstract: Activation-induced deaminase (AID) initiates the secondary antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR), both of which require AID. AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA double stranded breaks during SHM/CSR. In a physiological context, AID targets immunoglobulin (Ig) loci to mediate SHM/CSR. However, recent studies reveal genome-wide access of AID to numerous non-Ig loci. Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired. In this review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA lesions.
authors.affiliation: Integrated Department of Immunology, University of Colorado Anschutz Medical Campus and National Jewish Health, Denver, CO, 80206, USA.
authors.forename: Zhangguo
authors.initials: Z
authors.lastname: Chen
authors.forename: Jing H
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000818:Animals; D000916:Antibody Diversity / Q000502:physiology; D001402:B-Lymphocytes / Q000378:metabolism / Q000502:physiology*; D003564:Cytidine Deaminase / Q000378:metabolism / Q000502:physiology*; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D017578:Immunoglobulin Class Switching / Q000502:physiology; D017354:Point Mutation / Q000502:physiology; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
chemical_list: D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase
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