title: Antihyperlipidemic and Antioxidant Potential of Paeonia emodi Royle against High-Fat Diet Induced Oxidative Stress.
abstract: The present study was intended to evaluate the effects of Paeonia emodi rhizome extracts on serum triglycerides (TGs), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), atherogenic index (AI), superoxide dismutase (SOD), and glutathione peroxidase (GPx). The plant was extensively examined for its in vitro antioxidant activity, and the preliminary phytochemical screening was carried out using standard protocols. Male Wistar rats were induced with hyperlipidemia using high-fat diet and were treated orally with hydroalcoholic and aqueous extracts at the dose of 200 mg/kg bw for 30 days. TGs, TC, LDL-c, and AI were significantly reduced while HDL-c, SOD, and GPx levels rose to a considerable extent. After subjecting to acute toxicity testing, the extracts were found to be safe. The observations suggest antihyperlipidemic and antioxidant potential of P. emodi in high-fat diet induced hyperlipidemic/oxidative stressed rats.
authors.affiliation: Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir 190006, India.
authors.forename: Bilal A
authors.initials: BA
authors.lastname: Zargar
authors.affiliation: Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir 190006, India.
authors.forename: Mubashir H
authors.initials: MH
authors.lastname: Masoodi
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, New Delhi 110062, India.
authors.forename: Bahar
authors.initials: B
authors.lastname: Ahmed
authors.affiliation: Department of Clinical Biochemistry, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir 190006, India.
authors.forename: Showkat A
authors.initials: SA
authors.lastname: Ganie
references.citation: Clin Biochem. 1999 Nov;32(8):595-603
references.pmid: 10638941
references.citation: Life Sci. 1997;60(10):763-71
references.pmid: 9064481
references.citation: Am J Cardiol. 2003 Feb 6;91(3A):12A-16A
references.pmid: 12645639
references.citation: Biomed Environ Sci. 2013 Mar;26(3):209-21
references.pmid: 23425804
references.citation: Anal Biochem. 1987 Aug 15;165(1):215-9
references.pmid: 3120621
references.citation: Exp Toxicol Pathol. 2013 Jul;65(5):485-8
references.pmid: 22440113
references.citation: Science. 1973 Feb 9;179(4073):588-90
references.pmid: 4686466
references.citation: Biochem J. 1984 Apr 1;219(1):1-14
references.pmid: 6326753
references.citation: Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):29-38
references.pmid: 15539615
references.citation: Eur J Biochem. 1974 Sep 16;47(3):469-74
references.pmid: 4215654
references.citation: Exp Toxicol Pathol. 2013 Jan;65(1-2):55-60
references.pmid: 21764274
references.citation: Br J Nutr. 2001 May;85 Suppl 2:S67-74
references.pmid: 11509092
references.citation: Food Chem Toxicol. 1995 Jul;33(7):601-17
references.pmid: 7628797
references.citation: Indian J Biochem Biophys. 2009 Dec;46(6):467-81
references.pmid: 20361710
references.citation: Carcinogenesis. 1989 Jun;10(6):1003-8
references.pmid: 2470525
references.citation: Anal Biochem. 1971 Nov;44(1):276-87
references.pmid: 4943714
references.citation: Exp Toxicol Pathol. 2013 Jan;65(1-2):135-41
references.pmid: 21852078
references.citation: J Agric Food Chem. 2002 Nov 6;50(23):6882-90
references.pmid: 12405792
references.citation: Atherosclerosis. 1995 Sep;117(1):61-71
references.pmid: 8546756
references.citation: Am J Clin Nutr. 1993 May;57(5 Suppl):715S-724S; discussion 724S-725S
references.pmid: 8475889