title: Sudden hearing loss followed by deep vein thrombosis and pulmonary embolism in a patient with factor V Leiden mutation.
abstract: OBJECTIVE
  Factor V Leiden (FVL) is by far the most prevalent inherited thrombophilic abnormality in Western countries, and this genetic condition has been associated with sudden sensorineural hearing loss (SSHL). Audiologists should be aware that SSHL may be the precursor of life-threatening thromboembolic events, especially in Caucasians who are more likely to be FVL carriers.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A 41-year-old male patient.
  
  
  RESULTS
  Although this is not the first report of SSHL in a FVL carrier, it is the first to describe SSHL occurring in a heterozygous FVL carrier who--within a month--was also diagnosed with deep vein thrombosis of the left common femoral, saphenous, and popliteal veins, and pulmonary embolism of the left pulmonary artery branch serving the posterior basal segment of the inferior lobe.
  
  
  CONCLUSIONS
  SSHL is an emergency condition that warrants prompt medical examination and treatment. Hematological investigations should be considered in SSHL patients at least for those with a family history of thrombotic events, and for women on estrogen-progestin therapy or during pregnancy, with a view to providing adequate antithrombotic prophylaxis and reducing the risk of other thromboembolic events.
authors.affiliation: Department of Neurosciences, Otolaryngology Section, University of Padova , Italy.
authors.forename: A
authors.initials: A
authors.lastname: Lovato
authors.forename: D
authors.initials: D
authors.lastname: Tormene
authors.forename: C
authors.initials: C
authors.lastname: Staffieri
authors.forename: S
authors.initials: S
authors.lastname: Breda
authors.forename: A
authors.initials: A
authors.lastname: Staffieri
authors.forename: G
authors.initials: G
authors.lastname: Marioni
mesh_terms: D020016:Activated Protein C Resistance / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D004252:DNA Mutational Analysis; D005165:Factor V / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005938:Glucocorticoids / Q000627:therapeutic use; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003639:Hearing Loss, Sudden / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006579:Heterozygote; D006801:Humans; D008297:Male; D009154:Mutation; D010641:Phenotype; D011237:Predictive Value of Tests; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000925:Anticoagulants; D005938:Glucocorticoids; C095381:factor V Leiden; D005165:Factor V
keywords: Sudden sensorineural hearing loss; deep vein thrombosis; factor V Leiden; pulmonary embolism