title: [Medication adherence to secondary prevention for coronary artery disease].
abstract: We compared the use of evidence-based secondary prevention drugs for coronary artery disease at hospital discharge and 3 years of follow-up in a group of patients associated to an integrated network of health services. We conducted a retrospective group study that included 125 patients under 80 years of age who were hospitalized for acute coronary syndrome. McNemar's test was used to compare values at baseline and 3 years. The mean age of of participants was 63.7 years (SD ± 10.08) and 65.6% (95% CI 56.6-73.9) of male sex. The average follow-up time was 2.94 years (SD ± 0.25). The use of secondary prevention drugs for coronary heart disease decreased at 3 years of follow-up: anti-platelet 97.6 to 88.0% (p = 0.012), beta-blockers 94.4 to 84.8% (p = 0.021) and statins 83.7 to 91.2% (p = 0.035). Patients medicated with a combination of anti-platelet, beta blockers and statins showed a decrease from 86.4 to 66.3% (p < 0.0001). It is necessary to study the causes for the decreased adherence to long-term cardio-protective drugs.
authors.affiliation: Plan de Salud, Hospital Italiano de Buenos Aires, Argentina. E-mail: emiliano.rossi@hospitalitaliano.org.ar.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Rossi
authors.forename: Gastón
authors.initials: G
authors.lastname: Perman
authors.forename: Hernán
authors.initials: H
authors.lastname: Michelangelo
authors.forename: Claudia B
authors.initials: CB
authors.lastname: Alonzo
authors.forename: Laura
authors.initials: L
authors.lastname: Brescacin
authors.forename: Karin S
authors.initials: KS
authors.lastname: Kopitowski
authors.forename: José L
authors.initials: JL
authors.lastname: Navarro Estrada
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy / Q000517:prevention & control*; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage; D015331:Cohort Studies; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D012189:Retrospective Studies; D055502:Secondary Prevention
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors
keywords: coronary artery disease; medication adherence; secondary prevention