title: Bioreducible polymers for therapeutic gene delivery.
abstract: Most currently available cationic polymers have significant acute toxicity concerns such as cellular toxicity, aggregation of erythrocytes, and entrapment in the lung capillary bed, largely due to their poor biocompatibility and non-degradability under physiological conditions. To develop more intelligent polymers, disulfide bonds are introduced in the design of biodegradable polymers. Herein, the sustained innovations of biomimetic nano-sized constructs with bioreducible poly(disulfide amine)s demonstrate a viable clinical tool for the treatment of cardiovascular disease, anemia, diabetes, and cancer.
authors.affiliation: Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, USA. Electronic address: mdysgrace.lee@utah.edu.
authors.forename: Young Sook
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, USA; Department of Bioengineering, College of Engineering, Hanyang University, Seoul, Republic of Korea. Electronic address: sw.kim@pharm.utah.edu.
authors.forename: Sung Wan
authors.initials: SW
authors.lastname: Kim
mesh_terms: D000256:Adenoviridae; D001672:Biocompatible Materials; D002318:Cardiovascular Diseases / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D053758:Nanoparticles; D009369:Neoplasms / Q000628:therapy*; D010957:Plasmids; D011108:Polymers / Q000737:chemistry*; D034741:RNA, Small Interfering
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D034741:RNA, Small Interfering
keywords: Bioreducible polymer; Cardiovascular disease; Diabetes; Gene; Oncolytic adenovirus; Targeting
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