title: Inhibitory Effects of Gymnema (Gymnema sylvestre) Leaves on Tumour Promotion in Two-Stage Mouse Skin Carcinogenesis.
abstract: Ethanol extracts of gymnema (Gymnema sylvestre) leaves exhibited marked antitumour-promoting activity in an in vivo two-stage carcinogenesis test in mice using 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. From the active fraction of the ethanol extract of the gymnema leaves, three triterpenoids were isolated and identified. These compounds were evaluated for their inhibitory effects on TPA-induced inflammation (1 µg/ear) in mice. The tested compounds showed marked anti-inflammatory effects, with a 50% inhibitory dose of 50-555 nmol/ear.
authors.affiliation: School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Yasukawa
authors.affiliation: School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan.
authors.forename: Sakiko
authors.initials: S
authors.lastname: Okuda
authors.affiliation: School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Nobushi
references.citation: Chem Pharm Bull (Tokyo). 1997 Oct;45(10):1671-6
references.pmid: 9353896
references.citation: Can Fam Physician. 2009 Jun;55(6):591-6
references.pmid: 19509199
references.citation: Carbohydr Res. 2006 Jul 24;341(10):1697-701
references.pmid: 16603139
references.citation: J Integr Plant Biol. 2008 May;50(5):589-92
references.pmid: 18713427
references.citation: Biol Pharm Bull. 2001 Jun;24(6):713-7
references.pmid: 11411567
references.citation: Carbohydr Res. 2004 Mar 15;339(4):891-5
references.pmid: 14980834
references.citation: Phytochemistry. 2000 Apr;53(8):893-9
references.pmid: 10820799
references.citation: Biol Pharm Bull. 2001 Jun;24(6):643-9
references.pmid: 11411552
references.citation: J Asian Nat Prod Res. 2000;2(4):321-7
references.pmid: 11249615
references.citation: Diabetes Care. 2003 Apr;26(4):1277-94
references.pmid: 12663610
references.citation: Chem Pharm Bull (Tokyo). 1989 Apr;37(4):1071-3
references.pmid: 2766409
references.citation: Phytochemistry. 1996 Mar;41(4):1181-5
references.pmid: 8728717
references.citation: Biochem Biophys Res Commun. 1979 Oct 12;90(3):976-83
references.pmid: 292437
references.citation: Chem Pharm Bull (Tokyo). 1997 Dec;45(12):2034-8
references.pmid: 9433774
references.citation: Chem Pharm Bull (Tokyo). 1992 Jun;40(6):1366-75
references.pmid: 1327559
references.citation: Chem Pharm Bull (Tokyo). 1996 Feb;44(2):469-71
references.pmid: 8998848
references.citation: Chem Pharm Bull (Tokyo). 2004 Feb;52(2):270-5
references.pmid: 14758017