title: Successful therapy of macrophage activation syndrome with dexamethasone palmitate.
abstract: Macrophage activation syndrome (MAS) is a severe and potential life-threatening complication of childhood systemic inflammatory disorders. Corticosteroids are commonly used as the first-line therapy for MAS. We report four patients with MAS who were successfully treated with dexamethasone palmitate (DexP), a liposome-incorporated dexamethasone, much more efficient than free corticosteroids. DexP effectively inhibited inflammation in MAS patients in whom the response to pulse methylprednisolone was not sufficient to manage their diseases. DexP was also effective as the first-line therapy for MAS. Based on these findings, DexP is an effective therapy in treating MAS patients.
authors.affiliation: a Department of Pediatric Rheumatology , Hyogo Prefectural Kobe Children's Hospital , Kobe , Hyogo , Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nakagishi
authors.affiliation: b Department of Pediatrics , School of Medicine, Institute of Medical Pharmaceutical, and Health Sciences, Kanazawa University , Kanazawa , Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Shimizu
authors.affiliation: a Department of Pediatric Rheumatology , Hyogo Prefectural Kobe Children's Hospital , Kobe , Hyogo , Japan.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Kasai
authors.affiliation: a Department of Pediatric Rheumatology , Hyogo Prefectural Kobe Children's Hospital , Kobe , Hyogo , Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Miyoshi
authors.affiliation: b Department of Pediatrics , School of Medicine, Institute of Medical Pharmaceutical, and Health Sciences, Kanazawa University , Kanazawa , Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yachie
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage* / Q000494:pharmacology; D019468:Disease Management; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis; D055501:Macrophage Activation Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D010168:Palmitates / Q000494:pharmacology; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D010168:Palmitates; D003907:Dexamethasone
keywords: Dexamethasone palmitate; Macrophage activation syndrome; Systemic juvenile idiopathic arthritis