title: Synthesis of N-alkyl isatins via oxidative cyclization of N-alkyl 2-bromo(chloro)acetanilides.
abstract: A highly efficient method for the synthesis of N-alkyl isatins starting from N-alkyl 2-bromo or 2-chloro acetanilides is described. The starting materials are easy to prepare and the yields of isatins are generally high. Operationally the reaction is very simple to run. Even though best results were obtained with a catalytic amount of CuI, the reactions of N-alkyl 2-bromo acetanilides actually performed well even in the absence of any metal catalyst.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. ztanze@gmail.com.
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Gui
authors.forename: Fenglin
authors.initials: F
authors.lastname: Dai
authors.forename: Jidan
authors.initials: J
authors.lastname: Liu
authors.forename: Peixing
authors.initials: P
authors.lastname: Chen
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Yang
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.forename: Ze
authors.initials: Z
authors.lastname: Tan
mesh_terms: D000083:Acetanilides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D007510:Isatin / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D000083:Acetanilides; D003300:Copper; D007510:Isatin