title: Rgb: a scriptable genome browser for R.
abstract: CONCLUSIONS
  Thanks to its free licensing and the development of initiatives like Bioconductor, R has become an essential part of the bioinformatics toolbox in the past years and is more and more confronted with genomically located data. While separate solutions are available to manipulate and visualize such data, no R package currently offers the efficiency required for computationally intensive tasks such as interactive genome browsing. The package proposed here fulfills this specific need, providing a multilevel interface suitable for most needs, from a completely interfaced genome browser to low-level classes and methods. Its time and memory efficiency have been challenged in a human dataset, where it outperformed existing solutions by several orders of magnitude.
  
  
  METHODS
  R sources and packages are freely available at the CRAN repository and dedicated Web site: http://bioinformatics.ovsa.fr/Rgb. Distributed under the GPL 3 license, compatible with most operating systems (Windows, Linux, Mac OS) and architectures.
  
  
  BACKGROUND
  maressyl@gmail.com or fabrice.jardin@chb.unicancer.fr
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Centre Henri Becquerel, INSERM UMR 918, 76038 Rouen Cedex 1, France, Normandy University, University of Rouen, 76821 Mont-Saint-Aignan, France, Institute for Research and Innovation in Biomedicine (IRIB), Haute-Normandie, 76183 Rouen Cedex, France and LITIS, INSA EA 4108, 76801 Saint-Etienne-du-Rouvray, FranceCentre Henri Becquerel, INSERM UMR 918, 76038 Rouen Cedex 1, France, Normandy University, University of Rouen, 76821 Mont-Saint-Aignan, France, Institute for Research and Innovation in Biomedicine (IRIB), Haute-Normandie, 76183 Rouen Cedex, France and LITIS, INSA EA 4108, 76801 Saint-Etienne-du-Rouvray, FranceCentre Henri Becquerel, INSERM UMR 918, 76038 Rouen Cedex 1, France, Normandy University, University of Rouen, 76821 Mont-Saint-Aignan, France, Institute for Research and Innovation in Biomedicine (IRIB), Haute-Normandie, 76183 Rouen Cedex, France and LITIS, INSA EA 4108, 76801 Saint-Etienne-du-Rouvray, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Mareschal
authors.affiliation: Centre Henri Becquerel, INSERM UMR 918, 76038 Rouen Cedex 1, France, Normandy University, University of Rouen, 76821 Mont-Saint-Aignan, France, Institute for Research and Innovation in Biomedicine (IRIB), Haute-Normandie, 76183 Rouen Cedex, France and LITIS, INSA EA 4108, 76801 Saint-Etienne-du-Rouvray, FranceCentre Henri Becquerel, INSERM UMR 918, 76038 Rouen Cedex 1, France, Normandy University, University of Rouen, 76821 Mont-Saint-Aignan, France, Institute for Research and Innovation in Biomedicine (IRIB), Haute-Normandie, 76183 Rouen Cedex, France and LITIS, INSA EA 4108, 76801 Saint-Etienne-du-Rouvray, FranceCentre Henri Becquerel, INSERM UMR 918, 76038 Rouen Cedex 1, France, Normandy University, University of Rouen, 76821 Mont-Saint-Aignan, France, Institute for Research and Innovation in Biomedicine (IRIB), Haute-Normandie, 76183 Rouen Cedex, France and LITIS, INSA EA 4108, 76801 Saint-Etienne-du-Rouvray, France.
authors.forename: Sydney
authors.initials: S
authors.lastname: Dubois
authors.affiliation: Centre Henri Becquerel, INSERM UMR 918, 76038 Rouen Cedex 1, France, Normandy University, University of Rouen, 76821 Mont-Saint-Aignan, France, Institute for Research and Innovation in Biomedicine (IRIB), Haute-Normandie, 76183 Rouen Cedex, France and LITIS, INSA EA 4108, 76801 Saint-Etienne-du-Rouvray, FranceCentre Henri Becquerel, INSERM UMR 918, 76038 Rouen Cedex 1, France, Normandy University, University of Rouen, 76821 Mont-Saint-Aignan, France, Institute for Research and Innovation in Biomedicine (IRIB), Haute-Normandie, 76183 Rouen Cedex, France and LITIS, INSA EA 4108, 76801 Saint-Etienne-du-Rouvray, FranceCentre Henri Becquerel, INSERM UMR 918, 76038 Rouen Cedex 1, France, Normandy University, University of Rouen, 76821 Mont-Saint-Aignan, France, Institute for Research and Innovation in Biomedicine (IRIB), Haute-Normandie, 76183 Rouen Cedex, France and LITIS, INSA EA 4108, 76801 Saint-Etienne-du-Rouvray, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Lecroq
authors.affiliation: Centre Henri Becquerel, INSERM UMR 918, 76038 Rouen Cedex 1, France, Normandy University, University of Rouen, 76821 Mont-Saint-Aignan, France, Institute for Research and Innovation in Biomedicine (IRIB), Haute-Normandie, 76183 Rouen Cedex, France and LITIS, INSA EA 4108, 76801 Saint-Etienne-du-Rouvray, FranceCentre Henri Becquerel, INSERM UMR 918, 76038 Rouen Cedex 1, France, Normandy University, University of Rouen, 76821 Mont-Saint-Aignan, France, Institute for Research and Innovation in Biomedicine (IRIB), Haute-Normandie, 76183 Rouen Cedex, France and LITIS, INSA EA 4108, 76801 Saint-Etienne-du-Rouvray, FranceCentre Henri Becquerel, INSERM UMR 918, 76038 Rouen Cedex 1, France, Normandy University, University of Rouen, 76821 Mont-Saint-Aignan, France, Institute for Research and Innovation in Biomedicine (IRIB), Haute-Normandie, 76183 Rouen Cedex, France and LITIS, INSA EA 4108, 76801 Saint-Etienne-du-Rouvray, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Jardin
mesh_terms: D000465:Algorithms; D015894:Genome, Human / Q000235:genetics; D023281:Genomics / Q000379:methods*; D006801:Humans; D014584:User-Computer Interface; D064878:Web Browser