title: Chemical constituents from the leaves of Juglans mandshurica.
abstract: Two new (1 and 3) and two known diarylheptanoids (2 and 4), along with two tetralones (5 and 6), one naphthoquinone (7), four phenylpropanoids (8-11), and one phenol (12) were isolated from the leaves of Juglans mandshurica. Their structures were elucidated on the basis of spectral and chemical data. Compounds 2 and 10 are firstly isolated from this plant and 8 and 12 were isolated from the Juglans genus for the first time. Among these compounds, only 7 exhibited moderate cytotoxicities against cultured MGC-803, A549, K562, and HeLa tumor cell lines with IC50 values of 25.90, 28.60, 39.06, 44.90 μM, respectively.
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, 133002, People's Republic of China.
authors.forename: Da Lei
authors.initials: DL
authors.lastname: Yao
authors.forename: Chang Hao
authors.initials: CH
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.forename: Mei
authors.initials: M
authors.lastname: Jin
authors.forename: Ming Shan
authors.initials: MS
authors.lastname: Zheng
authors.forename: Jiong Mo
authors.initials: JM
authors.lastname: Cui
authors.forename: Jong Keun
authors.initials: JK
authors.lastname: Son
authors.forename: Gao
authors.initials: G
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification*; D006801:Humans; D031324:Juglans; D020014:K562 Cells; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification*; D018515:Plant Leaves
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts