title: The monocyte-macrophage axis in the intestine.
abstract: Macrophages are one of the most abundant leucocytes in the intestinal mucosa where they are essential for maintaining homeostasis. However, they are also implicated in the pathogenesis of disorders such as inflammatory bowel disease (IBD), offering potential targets for novel therapies. Here we discuss the function of intestinal monocytes and macrophages during homeostasis and describe how these populations and their functions change during infection and inflammation. Furthermore, we review the current evidence that the intestinal macrophage pool requires continual renewal from circulating blood monocytes, unlike most other tissue macrophages which appear to derive from primitive precursors that subsequently self-renew.
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, United Kingdom.
authors.forename: Calum C
authors.initials: CC
authors.lastname: Bain
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, United Kingdom. Electronic address: Allan.Mowat@glasgow.ac.uk.
authors.forename: Allan McI
authors.initials: AM
authors.lastname: Mowat
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D005767:Gastrointestinal Diseases / Q000097:blood / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology* / Q000473:pathology; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D051379:Mice; D009000:Monocytes / Q000166:cytology / Q000276:immunology* / Q000473:pathology
keywords: Homeostasis; Inflammation; Intestine; Macrophages; Monocytes
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