title: Hypoglycemic and hypolipidemic activities of MT-α-glucan and its effect on immune function of diabetic mice.
abstract: The hypoglycemic and hypolipidemic effect of an α-glucan (designed here as MT-α-glucan) from fruit body of maitake (Grifola frondosa) on diabetic mouse model induced by streptozotocin and high-fat-diet were evaluated, and its effect on immune function of diabetic mice was investigated. Treatment with MT-α-glucan (300 or 100 mg kg(-1)) could decrease the levels of fasting plasma glucose, triglycerides, cholesterol, free fatty acid, the proliferative response of macrophages and IL-1, NO production by macrophages significantly. Treatment with MT-α-glucan could increase the serum insulin, the proliferative response and IL-2 production of splenocytes induced by ConA significantly. Ultrastructural changes of pancreatic β-cells were ameliorated in the treatment group. These data suggest that MT-α-glucan has hypoglycemic and hypolipidemic effect on the diabetic mice model, which might be related to its benefit effect on immune reactions involved in pathogenesis of diabetes mellitus, leading to attenuate the degree of injured β-cells of the pancreatic islets.
authors.affiliation: School of Biology and Food Engineering, Hefei University of Technology, Hefei 230009, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Lei
authors.affiliation: School of Biology and Food Engineering, Hefei University of Technology, Hefei 230009, China.
authors.forename: Shuzhen
authors.initials: S
authors.lastname: Guo
authors.affiliation: School of Biology and Food Engineering, Hefei University of Technology, Hefei 230009, China.
authors.forename: Juncheng
authors.initials: J
authors.lastname: Han
authors.affiliation: School of Biology and Food Engineering, Hefei University of Technology, Hefei 230009, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.affiliation: School of Biology and Food Engineering, Hefei University of Technology, Hefei 230009, China.
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Wutong
authors.initials: W
authors.lastname: Wu
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D049109:Cell Proliferation / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D059305:Diet, High-Fat; D048690:Fruiting Bodies, Fungal; D005936:Glucans / Q000494:pharmacology / Q000627:therapeutic use*; D048691:Grifola; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000473:pathology; D007375:Interleukin-1 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008810:Mice, Inbred C57BL; D009569:Nitric Oxide / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D013154:Spleen / Q000166:cytology
chemical_list: D001786:Blood Glucose; D005936:Glucans; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007328:Insulin; D007375:Interleukin-1; D007376:Interleukin-2; D008055:Lipids; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse