title: The use of microtechnology and nanotechnology in fabricating vascularized tissues.
abstract: Tissue engineering (TE) is a multidisciplinary research area that combines medicine, biology, and material science. In recent decades, microtechnology and nanotechnology have also been gradually integrated into this field and have become essential components of TE research. Tissues and complex organs in the body depend on a branched blood vessel system. One of the main objectives for TE researchers is to replicate this vessel system and obtain functional vascularized structures within engineered tissues or organs. With the help of new nanotechnology and microtechnology, significant progress has been made. Achievements include the design of nanoscale-level scaffolds with new functionalities, development of integrated and rapid nanotechnology methods for biofabrication of vascular tissues, discovery of new composite materials to direct differentiation of stem and inducible pluripotent stem cells into the vascular phenotype. Although numerous challenges to replicating vascularized tissue for clinical uses remain, the combination of these new advances has yielded new tools for producing functional vascular tissues in the near future.
authors.forename: Raquel
authors.initials: R
authors.lastname: Obregón
authors.forename: Javier
authors.initials: J
authors.lastname: Ramón-Azcón
authors.forename: Samad
authors.initials: S
authors.lastname: Ahadian
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shiku
authors.forename: Hojae
authors.initials: H
authors.lastname: Bae
authors.forename: Murugan
authors.initials: M
authors.lastname: Ramalingam
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Matsue
mesh_terms: D021522:Bioartificial Organs; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D001808:Blood Vessels / Q000166:cytology / Q000254:growth & development*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000295:instrumentation*; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials