title: [Outcomes of surgical correction of congenital tibia pseudarthrosis depending on the activation of HHV-6/HHV-7 viral infection in a child with neurofibromatosis type-1].
abstract: Neurofibromatosis type-1 (NF-1)--is a common genetic disease effecting the skin, subcutaneous tissue peripheral nerves and bones (tibia pseudarthrosis). Immunomodulatory viruses HHV-6 and HHV-7 are classifying as a genus of roseoloviruses of subfamily beta-herpesviruses. Reactivation of HHV-6 and HHV-7 inhibits immune system and indirectly promote to other infectious agents. The article deals with a unique case repot of two repeated transplantations of fibula due to congenital tibia pseudarthrosis caused by NF-1. Results of the transplantations, related to active and latent HHV-6 and HHV-7 infection in a 6 years old child are discussed in the paper.
authors.forename: A
authors.initials: A
authors.lastname: Vilks
authors.forename: D
authors.initials: D
authors.lastname: Ozols
authors.forename: V
authors.initials: V
authors.lastname: Boka
authors.forename: M
authors.initials: M
authors.lastname: Murovska
authors.forename: B
authors.initials: B
authors.lastname: Mamaia
mesh_terms: D002675:Child, Preschool; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D016199:Herpesvirus 7, Human / Q000302:isolation & purification*; D006801:Humans; D038061:Lower Extremity Deformities, Congenital / Q000150:complications / Q000276:immunology / Q000601:surgery* / Q000821:virology; D008297:Male; D011542:Pseudarthrosis / Q000150:complications / Q000276:immunology / Q000601:surgery* / Q000821:virology; D012086:Reoperation; D019349:Roseolovirus Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D013977:Tibia / Q000276:immunology / Q000601:surgery* / Q000821:virology; D017211:Treatment Failure; D016896:Treatment Outcome