title: Effect of impeller design and spacing on gas exchange in a percutaneous respiratory assist catheter.
abstract: Providing partial respiratory assistance by removing carbon dioxide (CO2 ) can improve clinical outcomes in patients suffering from acute exacerbations of chronic obstructive pulmonary disease and acute respiratory distress syndrome. An intravenous respiratory assist device with a small (25 Fr) insertion diameter eliminates the complexity and potential complications associated with external blood circuitry and can be inserted by nonspecialized surgeons. The impeller percutaneous respiratory assist catheter (IPRAC) is a highly efficient CO2 removal device for percutaneous insertion to the vena cava via the right jugular or right femoral vein that utilizes an array of impellers rotating within a hollow-fiber membrane bundle to enhance gas exchange. The objective of this study was to evaluate the effects of new impeller designs and impeller spacing on gas exchange in the IPRAC using computational fluid dynamics (CFD) and in vitro deionized water gas exchange testing. A CFD gas exchange and flow model was developed to guide a progressive impeller design process. Six impeller blade geometries were designed and tested in vitro in an IPRAC device with 2- or 10-mm axial spacing and varying numbers of blades (2-5). The maximum CO2 removal efficiency (exchange per unit surface area) achieved was 573 ± 8 mL/min/m(2) (40.1 mL/min absolute). The gas exchange rate was found to be largely independent of blade design and number of blades for the impellers tested but increased significantly (5-10%) with reduced axial spacing allowing for additional shaft impellers (23 vs. 14). CFD gas exchange predictions were within 2-13% of experimental values and accurately predicted the relative improvement with impellers at 2- versus 10-mm axial spacing. The ability of CFD simulation to accurately forecast the effects of influential design parameters suggests it can be used to identify impeller traits that profoundly affect facilitated gas exchange.
authors.affiliation: Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: R Garrett
authors.initials: RG
authors.lastname: Jeffries
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Frankowski
authors.forename: Greg W
authors.initials: GW
authors.lastname: Burgreen
authors.forename: William J
authors.initials: WJ
authors.lastname: Federspiel
mesh_terms: D002245:Carbon Dioxide / Q000097:blood*; D057785:Catheters; D004867:Equipment Design; D006801:Humans; D011659:Pulmonary Gas Exchange; D012131:Respiratory Insufficiency / Q000097:blood* / Q000628:therapy*
chemical_list: D002245:Carbon Dioxide
keywords: Acute respiratory distress syndrome; Artificial lungs; Blood oxygenator; CO2 removal; Chronic obstructive pulmonary disease; Gas exchange; Impeller design
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