title: Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe.
abstract: We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ42-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Yeon Ok
authors.initials: YO
authors.lastname: Lee
authors.forename: Jung-Won
authors.initials: JW
authors.lastname: Shin
authors.forename: Chunsik
authors.initials: C
authors.lastname: Yi
authors.forename: Yun Hak
authors.initials: YH
authors.lastname: Lee
authors.forename: Nak-Won
authors.initials: NW
authors.lastname: Sohn
authors.forename: Chulhun
authors.initials: C
authors.lastname: Kang
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D010446:Peptide Fragments / Q000737:chemistry*; D055503:Protein Multimerization; D017433:Protein Structure, Secondary; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D005456:Fluorescent Dyes; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D014867:Water