title: Does cabergoline help in decreasing endometrioma size compared to LHRH agonist? A prospective randomized study.
abstract: OBJECTIVE
  The aim of this study was to compare the efficiency of dopamine agonist, Cabergoline, in decreasing the size of endometrioma, with that of luteinizing hormone releasing hormone (LHRH) agonist, triptorelin acetate.
  
  
  METHODS
  This was a prospective, randomized study.
  
  
  METHODS
  The setting was in two private medical centers in the UAE, from January 2011 to February 2012.
  
  
  METHODS
  One hundred and forty patients complaining of endometrioma, and fulfilling the eligibility criteria, were chosen and divided into two groups as follows: Group I comprised 71 patients; all of them received Cabergoline tablets, 0.5 mg tablets, twice per week for 12 weeks. Group II comprised 69 patients; all of them received LHRH agonist, decapeptyl, 3.75 mg subcutaneous, single injection, once a month for 3 months. All patients underwent vaginal ultrasound before and after the treatment period to compare the change in the size of endometrioma by the same sonography team in each hospital that was blind to the treatment groups.
  
  
  RESULTS
  The outcome was measured by the changes in the endometrioma size by vaginal ultrasound after completion of the 3 months' treatment period. The management line was considered to be significantly effective if the endometrioma size was reduced by more than 25 % of its original pretreatment size.
  
  
  RESULTS
  Group I: 46 out of the 71 patients (64.7 %) had significant decrease in endometrioma size. Group II: 15 out of 69 patients (21.7 %) had significant decrease in endometrioma size. Paired t test to compare the means of the two groups was highly significant (p < 0.05) CONCLUSION: Cabergoline (dostinex) yields better results in decreasing the size of endometrioma, compared to LHRH-agonist by exerting antiangiogenic effects through vascular endothelial growth factor receptor-2 (VEGFR-2) inactivation. It has no major side effects, easier to administer, and cheaper than LHRH agonists.
authors.affiliation: Obstetrics and Gynecology Department, Ain Shams University, Cairo, Egypt, amoura100@yahoo.com.
authors.forename: Amr M Salaheldin Abdel
authors.initials: AM
authors.lastname: Hamid
authors.forename: Wael A Ismail
authors.initials: WA
authors.lastname: Madkour
authors.forename: Ashraf
authors.initials: A
authors.lastname: Moawad
authors.forename: Mohamed Abd
authors.initials: MA
authors.lastname: Elzaher
authors.forename: Mary P
authors.initials: MP
authors.lastname: Roberts
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000077465:Cabergoline; D018491:Dopamine Agonists / Q000627:therapeutic use*; D004715:Endometriosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D004873:Ergolines / Q000627:therapeutic use*; D005260:Female; D005831:Genital Diseases, Female / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D007279:Injections, Subcutaneous; D008186:Luteolytic Agents / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D011446:Prospective Studies; D017329:Triptorelin Pamoate / Q000627:therapeutic use*; D014463:Ultrasonography
chemical_list: D018491:Dopamine Agonists; D004873:Ergolines; D008186:Luteolytic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D000077465:Cabergoline