title: Silver nanoparticle-loaded PVA/gum acacia hydrogel: synthesis, characterization and antibacterial study.
abstract: A simple one-pot method for in situ synthesis of silver nanoparticles (AgNPs), within polyvinyl alcohol/gum acacia (PVA-GA) hydrogel matrix, by gamma radiation-induced cross-linking is reported here. The synthesized hydrogels were characterized by FT-IR, thermogravimetry, dynamic light scattering and inductively coupled mass spectrometry method. The thermal stability was found to be more for the hydrogel loaded with silver nanoparticles and also the percentage silver loading was found to increase with increase in cross-linking density. The influence of gum acacia (GA) concentration on the equilibrium degree of swelling of the synthesized hydrogels, and also on the silver release from hydrogel matrix, was investigated. The size of the silver nanoparticles formed in the hydrogel matrix was in the range of 10-40 nm. The rheological gel point was found to be at 25.34 kGy of radiation dose, for a typical hydrogel synthesized, using 5% GA, 3% PVA and 1mM AgNO3. The antibacterial studies of the synthesized nanosilver-containing hydrogels showed good antibacterial activity against gram-negative bacterium, Escherichia coli.
authors.affiliation: Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: K A
authors.initials: KA
authors.lastname: Juby
authors.affiliation: Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: Charu
authors.initials: C
authors.lastname: Dwivedi
authors.affiliation: Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: Manmohan
authors.initials: M
authors.lastname: Kumar
authors.affiliation: Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: Swathi
authors.initials: S
authors.lastname: Kota
authors.affiliation: Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: H S
authors.initials: HS
authors.lastname: Misra
authors.affiliation: Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: P N
authors.initials: PN
authors.lastname: Bajaj
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D020100:Hydrogels / Q000737:chemistry*; D013058:Mass Spectrometry; D053768:Metal Nanoparticles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D012834:Silver / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D020100:Hydrogels; D012834:Silver