title: Synthesis of proposed aglycone of mandelalide A.
abstract: A highly convergent synthesis of the proposed mandelalide A aglycone is reported. The cornerstones of the synthetic strategy include the following: E-selective intramolecular Heck cyclization, Masamune-Roush olefination, Stork-Zhao-Wittig olefination, modified Prins cyclization; Sharpless asymmetric dihydroxylation followed by Williamson-type etherification, Julia-Kocienski olefination, Brown crotylation, and Brown allylation reactions.
authors.affiliation: Organic and Biomolecular Chemistry Division, ‡Centre for NMR & Structural Chemistry, CSIR-Indian Institute of Chemical Technology , Tarnaka, Hyderabad-500007, India.
authors.forename: Karla Mahender
authors.initials: KM
authors.lastname: Reddy
authors.forename: Vanipenta
authors.initials: V
authors.lastname: Yamini
authors.forename: Kiran K
authors.initials: KK
authors.lastname: Singarapu
authors.forename: Subhash
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D014561:Urochordata / Q000737:chemistry*
chemical_list: D018942:Macrolides; C000589407:mandelalide A