title: Snake venom L-amino acid oxidases: trends in pharmacology and biochemistry.
abstract: L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is primarily due to enzymatic activity, but other mechanisms have been proposed recently which require further investigation. L-amino acid oxidases exert biological and pharmacological effects, including actions on platelet aggregation and the induction of apoptosis, hemorrhage, and cytotoxicity. These proteins present a high biotechnological potential for the development of antimicrobial, antitumor, and antiprotozoan agents. This review provides an overview of the biochemical properties and pharmacological effects of snake venom L-amino acid oxidases, their structure/activity relationship, and supposed mechanisms of action described so far.
authors.affiliation: Faculdade de Ciências Integradas do Pontal e Departamento de Genética e Bioquímica, Universidade Federal de Uberlândia (UFU), Uberlândia, MG, Brazil.
authors.forename: Luiz Fernando M
authors.initials: LF
authors.lastname: Izidoro
authors.affiliation: Centro de Estudos de Biomoléculas Aplicadas à Saúde, (CEBio), Fundação Oswaldo Cruz, Fiocruz Rondônia e Departamento de Medicina, Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brazil.
authors.forename: Juliana C
authors.initials: JC
authors.lastname: Sobrinho
authors.affiliation: Faculdade de Ciências Integradas do Pontal e Departamento de Genética e Bioquímica, Universidade Federal de Uberlândia (UFU), Uberlândia, MG, Brazil.
authors.forename: Mirian M
authors.initials: MM
authors.lastname: Mendes
authors.affiliation: Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Tássia R
authors.initials: TR
authors.lastname: Costa
authors.affiliation: Centro de Estudos de Biomoléculas Aplicadas à Saúde, (CEBio), Fundação Oswaldo Cruz, Fiocruz Rondônia e Departamento de Medicina, Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brazil.
authors.forename: Amy N
authors.initials: AN
authors.lastname: Grabner
authors.affiliation: Faculdade de Ciências Integradas do Pontal e Departamento de Genética e Bioquímica, Universidade Federal de Uberlândia (UFU), Uberlândia, MG, Brazil.
authors.forename: Veridiana M
authors.initials: VM
authors.lastname: Rodrigues
authors.affiliation: Departamento de Química, Biotecnologia e Engenharia de Bioprocessos, Universidade Federal de São João del Rei (UFSJ), Campus Altoparaopeba, Ouro Branco, MG, Brazil.
authors.forename: Saulo L
authors.initials: SL
authors.lastname: da Silva
authors.affiliation: Centro de Estudos de Biomoléculas Aplicadas à Saúde, (CEBio), Fundação Oswaldo Cruz, Fiocruz Rondônia e Departamento de Medicina, Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brazil.
authors.forename: Fernando B
authors.initials: FB
authors.lastname: Zanchi
authors.affiliation: Centro de Estudos de Biomoléculas Aplicadas à Saúde, (CEBio), Fundação Oswaldo Cruz, Fiocruz Rondônia e Departamento de Medicina, Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brazil.
authors.forename: Juliana P
authors.initials: JP
authors.lastname: Zuliani
authors.affiliation: Centro de Estudos de Biomoléculas Aplicadas à Saúde, (CEBio), Fundação Oswaldo Cruz, Fiocruz Rondônia e Departamento de Medicina, Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brazil.
authors.forename: Carla F C
authors.initials: CF
authors.lastname: Fernandes
authors.affiliation: Centro de Estudos de Biomoléculas Aplicadas à Saúde, (CEBio), Fundação Oswaldo Cruz, Fiocruz Rondônia e Departamento de Medicina, Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brazil.
authors.forename: Leonardo A
authors.initials: LA
authors.lastname: Calderon
authors.affiliation: Centro de Estudos de Biomoléculas Aplicadas à Saúde, (CEBio), Fundação Oswaldo Cruz, Fiocruz Rondônia e Departamento de Medicina, Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brazil.
authors.forename: Rodrigo G
authors.initials: RG
authors.lastname: Stábeli
authors.affiliation: Centro de Estudos de Biomoléculas Aplicadas à Saúde, (CEBio), Fundação Oswaldo Cruz, Fiocruz Rondônia e Departamento de Medicina, Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brazil.
authors.forename: Andreimar M
authors.initials: AM
authors.lastname: Soares
mesh_terms: D001685:Biological Factors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D050830:L-Amino Acid Oxidase / Q000737:chemistry* / Q000494:pharmacology*; D012910:Snake Venoms / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D001685:Biological Factors; D012910:Snake Venoms; D050830:L-Amino Acid Oxidase
references.citation: Comp Biochem Physiol A Mol Integr Physiol. 2008 Dec;151(4):542-50
references.pmid: 18804547
references.citation: FEBS J. 2010 Jan;277(2):453-65
references.pmid: 20015076
references.citation: EMBO J. 2000 Aug 15;19(16):4204-15
references.pmid: 10944103
references.citation: Mol Biol Evol. 2000 Apr;17(4):540-52
references.pmid: 10742046
references.citation: Toxicon. 1986;24(7):726-9
references.pmid: 3775788
references.citation: Toxicon. 1991;29(9):1129-41
references.pmid: 1796476
references.citation: Toxicol In Vitro. 2003 Apr;17(2):169-77
references.pmid: 12650671
references.citation: Toxicon. 2006 Jan;47(1):47-57
references.pmid: 16307769
references.citation: Bioorg Med Chem. 2006 Oct 15;14(20):7034-43
references.pmid: 16809041
references.citation: J Exp Med. 1981 May 1;153(5):1302-15
references.pmid: 7252418
references.citation: Comp Biochem Physiol C Toxicol Pharmacol. 2011 Mar;153(2):237-42
references.pmid: 21059402
references.citation: Arch Biochem Biophys. 2000 Dec 15;384(2):216-26
references.pmid: 11368308
references.citation: Biochem Pharmacol. 2008 Jul 15;76(2):279-88
references.pmid: 18555977
references.citation: Biochimie. 2009 Apr;91(4):490-501
references.pmid: 19135502
references.citation: Biochimie. 2010 Apr;92(4):343-9
references.pmid: 20100538
references.citation: Electrophoresis. 1997 Dec;18(15):2714-23
references.pmid: 9504803
references.citation: Biochim Biophys Acta. 1971 Jan 13;227(1):16-31
references.pmid: 5543584
references.citation: Toxicon. 2009 Mar 1;53(3):330-41
references.pmid: 19101583
references.citation: Toxicon. 2013 Mar 15;64:1-11
references.pmid: 23287728
references.citation: Mycol Res. 2008 Dec;112(Pt 12):1453-64
references.pmid: 18675352
references.citation: Eur J Biochem. 2001 Mar;268(6):1679-86
references.pmid: 11248687
references.citation: Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Mar;35(3):219-24
references.pmid: 12621545
references.citation: Biochim Biophys Acta. 2003 Jun 26;1649(1):51-7
references.pmid: 12818190
references.citation: Biochim Biophys Acta. 2001 Jan 12;1544(1-2):267-77
references.pmid: 11341935
references.citation: J Mol Biol. 2006 Dec 15;364(5):991-1002
references.pmid: 17046020
references.citation: Toxicon. 1993 Nov;31(11):1459-69
references.pmid: 8310446
references.citation: Int J Biochem. 1992 Jun;24(6):967-73
references.pmid: 1612186
references.citation: Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 May;34(3):305-10
references.pmid: 12019442
references.citation: J Biol Chem. 1977 Nov 25;252(22):8035-9
references.pmid: 21187
references.citation: Toxicon. 1999 Aug;37(8):1095-107
references.pmid: 10400294
references.citation: Toxicon. 1994 Nov;32(11):1349-58
references.pmid: 7886693
references.citation: Arch Biochem. 1950 Nov;29(1):190-209
references.pmid: 14790807
references.citation: Toxicon. 2009 Sep 1;54(3):262-71
references.pmid: 19393676
references.citation: J Immunol Methods. 1983 Dec 16;65(1-2):55-63
references.pmid: 6606682
references.citation: Immunol Today. 1994 Jan;15(1):7-10
references.pmid: 8136014
references.citation: Thromb Haemost. 1982 Dec 27;48(3):277-82
references.pmid: 7164017
references.citation: Anal Biochem. 1975 Jul;67(1):66-73
references.pmid: 1147239
references.citation: Toxicon. 2003 Mar;41(4):441-9
references.pmid: 12657313
references.citation: Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):974-7
references.pmid: 15103157
references.citation: Biochim Biophys Acta. 1968 Aug 27;167(1):35-47
references.pmid: 5693709
references.citation: Toxicon. 1998 Dec;36(12):1749-800
references.pmid: 9839663
references.citation: Toxicon. 1969 Nov;7(3):235-8
references.pmid: 5358068
references.citation: FEBS Lett. 2002 Nov 20;531(3):509-12
references.pmid: 12435602
references.citation: Appl Biochem Biotechnol. 1995 Spring;51-52:197-210
references.pmid: 7668847
references.citation: Toxicon. 2007 Sep 15;50(4):479-89
references.pmid: 17543361
references.citation: Rapid Commun Mass Spectrom. 2003;17(18):2047-62
references.pmid: 12955733
references.citation: Toxicon. 2005 Oct;46(5):479-89
references.pmid: 16153453
references.citation: J Bacteriol. 2005 Mar;187(6):2084-92
references.pmid: 15743957
references.citation: Comp Biochem Physiol C Toxicol Pharmacol. 2006 Mar-Apr;142(3-4):328-346
references.pmid: 16434235
references.citation: Bioorg Med Chem. 2004 Jun 1;12(11):2881-6
references.pmid: 15142548
references.citation: Toxicon. 2003 Apr;41(5):541-57
references.pmid: 12676433
references.citation: Biochem Cell Biol. 1989 Sep;67(9):597-601
references.pmid: 2553075
references.citation: Biochim Biophys Acta. 2011 Jul;1810(7):683-94
references.pmid: 21539897
references.citation: Anal Biochem. 2012 Jan 1;420(1):93-5
references.pmid: 21951783
references.citation: Biochim Biophys Acta. 1965 Jan;96:66-74
references.pmid: 14285268
references.citation: Yeast. 2008 May;25(5):349-57
references.pmid: 18437704
references.citation: Comp Biochem Physiol B Biochem Mol Biol. 2008 Apr;149(4):572-80
references.pmid: 18294891
references.citation: Toxicon. 2009 Nov;54(6):763-71
references.pmid: 19523971
references.citation: Biochem Biophys Res Commun. 2001 Jan 26;280(3):620-4
references.pmid: 11162565
references.citation: Biochem Biophys Res Commun. 2007 Apr 6;355(2):302-6
references.pmid: 17292326
references.citation: Experientia. 1977 Feb 15;33(2):143-50
references.pmid: 191284
references.citation: Toxicon. 1994 Aug;32(8):875-82
references.pmid: 7985193
references.citation: Syst Biol. 2003 Oct;52(5):696-704
references.pmid: 14530136
references.citation: Biochim Biophys Acta. 1987 Jan 30;911(2):201-8
references.pmid: 3801494
references.citation: Toxicon. 2007 Dec 15;50(8):1126-39
references.pmid: 17854853
references.citation: Toxicon. 2002 Jun;40(6):659-65
references.pmid: 12175601
references.citation: Biochem Biophys Res Commun. 1998 Jul 30;248(3):476-8
references.pmid: 9703950
references.citation: J Biol Chem. 1997 Apr 4;272(14):9539-42
references.pmid: 9083096
references.citation: Biochem Int. 1989 Oct;19(4):937-44
references.pmid: 2619759
references.citation: Eur J Biochem. 2001 Jul;268(14):4044-53
references.pmid: 11453999
references.citation: Int J Biol Macromol. 2007 Jul 1;41(2):132-40
references.pmid: 17320169
references.citation: Arch Biochem Biophys. 1971 Sep;146(1):54-63
references.pmid: 5169142
references.citation: Biochemistry. 1976 Jul 13;15(14):3070-6
references.pmid: 8082
references.citation: Dev Comp Immunol. 2003 Jun-Jul;27(6-7):505-12
references.pmid: 12697307
references.citation: Toxicon. 2010 Apr 1;55(4):795-804
references.pmid: 19944711
references.citation: J Immunol. 1998 Apr 15;160(8):4042-7
references.pmid: 9558114
references.citation: Biochem Biophys Res Commun. 1999 Feb 16;255(2):477-82
references.pmid: 10049734
references.citation: Toxicon. 2008 Feb;51(2):199-207
references.pmid: 17983639
references.citation: J Nat Toxins. 2002 Dec;11(4):345-52
references.pmid: 12503878
references.citation: Toxicon. 1985;23(2):337-40
references.pmid: 2992122
references.citation: Toxicon. 1988;26(8):695-706
references.pmid: 3188059
references.citation: Biochemistry. 1969 Apr;8(4):1405-11
references.pmid: 5817156
references.citation: Biochem Biophys Res Commun. 2003 Sep 26;309(3):598-604
references.pmid: 12963032
references.citation: Braz J Med Biol Res. 1991;24(3):249-60
references.pmid: 1823238
references.citation: Helv Chim Acta. 1945;28(7):1615-27
references.pmid: 20998074
references.citation: Arch Biochem Biophys. 1994 Sep;313(2):373-8
references.pmid: 8080286
references.citation: Biochim Biophys Acta. 2006 Apr;1764(4):707-14
references.pmid: 16574513
references.citation: Toxicon. 2005 Sep 1;46(3):308-17
references.pmid: 16026810
references.citation: Comp Biochem Physiol B. 1991;99(2):351-4
references.pmid: 1764914
references.citation: Biochimie. 2012 Feb;94(2):335-44
references.pmid: 21802487
references.citation: Life Sci. 2007 Mar 6;80(13):1189-97
references.pmid: 17275856
references.citation: Biochim Biophys Acta. 1980 Jan 11;611(1):11-26
references.pmid: 7350910
references.citation: Biochem Biophys Res Commun. 1973 Dec 19;55(4):1305-10
references.pmid: 4797836
references.citation: J Biol Chem. 1960 Jul;235:2013-8
references.pmid: 13843884
references.citation: Toxicon. 1993 Jul;31(7):865-72
references.pmid: 8212031
references.citation: Parasitol Res. 2002 Jul;88(7):598-602
references.pmid: 12107450
references.citation: Toxicon. 1987;25(11):1169-80
references.pmid: 3124297
references.citation: Toxicon. 2012 Dec 1;60(7):1263-76
references.pmid: 22963728
references.citation: Basic Clin Pharmacol Toxicol. 2008 Jun;102(6):533-42
references.pmid: 18346051
references.citation: Gene. 2004 Aug 4;337:55-69
references.pmid: 15276202
references.citation: Toxicon. 2001 Dec;39(12):1827-33
references.pmid: 11600144
references.citation: Arch Biochem Biophys. 1999 Aug 15;368(2):285-90
references.pmid: 10441379
references.citation: Comp Biochem Physiol B Biochem Mol Biol. 2008 Feb;149(2):394-400
references.pmid: 18055243
references.citation: Nucleic Acids Res. 1994 Nov 11;22(22):4673-80
references.pmid: 7984417
references.citation: Syst Biol. 2006 Aug;55(4):539-52
references.pmid: 16785212
references.citation: Nucleic Acids Res. 2004 Mar 19;32(5):1792-7
references.pmid: 15034147
references.citation: J Biol Chem. 1951 Nov;193(1):265-75
references.pmid: 14907713
references.citation: Nature. 1970 Mar 14;225(5237):1072-3
references.pmid: 4906571
references.citation: Toxicon. 2006 Aug;48(2):227-37
references.pmid: 16828829
references.citation: Dev Comp Immunol. 2013 Apr;39(4):456-9
references.pmid: 23295245
references.citation: Int J Biochem Cell Biol. 1997 Jun;29(6):911-9
references.pmid: 9304806