title: Pathway Activity Profiling (PAPi): a tool for metabolic pathway analysis.
abstract: Pathway Activity Profiling (PAPi) is a method developed to correlate levels of metabolites to the activity of metabolic pathways operating within biological systems. Based solely on a metabolomics data set and the Kyoto Encyclopedia of Genes and Genomes, PAPi predicts and compares the activity of metabolic pathways across experimental conditions, which considerably improves the hypothesis generation process for achieving the biological interpretation of biological studies. In this chapter, we describe how to apply PAPi to a metabolomics data set using the R-software.
authors.affiliation: Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, UK, Raphael.Aggio@liverpool.ac.uk.
authors.forename: Raphael B M
authors.initials: RB
authors.lastname: Aggio
mesh_terms: D000332:Aerobiosis; D000693:Anaerobiosis; D003196:Computer Graphics; D053858:Metabolic Networks and Pathways; D055432:Metabolomics / Q000379:methods*; D012984:Software; D014584:User-Computer Interface