title: Renal involvement in non-Hodgkin lymphoma: proven by renal biopsy.
abstract: OBJECTIVE
  To determine the spectrum of renal lesions in patients with kidney involvement in non-Hodgkin's lymphoma (NHL) by renal biopsy.
  
  
  METHODS
  The clinical features and histological findings at the time of the renal biopsy were assessed for each patient.
  
  
  RESULTS
  We identified 20 patients with NHL and renal involvement, and the diagnosis of NHL was established following the kidney biopsy in 18 (90%) patients. The types of NHL include the following: chronic lymphocytic leukemia/small lymphocytic lymphoma (n = 8), diffuse large B-cell lymphoma (n = 4), T/NK cell lymphoma (n = 3), lymphoplasmacytic lymphoma (n = 2), cutaneous T-cell lymphoma (n = 1), mucosa-associated lymphoid tissue lymphoma (n = 1) and mantle cell lymphoma (n = 1). All presented with proteinuria, and 15 patients had impaired renal function. The pathological findings included (1) membranoproliferative glomerulonephritis-like pattern in seven patients; (2) crescent glomerulonephritis in four; (3) minimal-change disease in three, and glomeruli without specific pathological abnormalities in three; (4) intraglomerular large B-cell lymphoma in one; (5) intracapillary monoclonal IgM deposits in one; (6) primary diffuse large B-cell lymphoma of the kidneys in one; and (7) lymphoma infiltration of the kidney in eight patients.
  
  
  CONCLUSIONS
  A wide spectrum of renal lesions can be observed in patients with NHL, and NHL may be first proven by renal biopsies for evaluation of kidney injury or proteinuria. Renal biopsy is necessary to establish the underlying cause of renal involvement in NHL.
authors.affiliation: National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University of Medcine, Nanjing, China.
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Li
authors.affiliation: National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University of Medcine, Nanjing, China.
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Chen
authors.affiliation: National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University of Medcine, Nanjing, China.
authors.forename: Ying-Hua
authors.initials: YH
authors.lastname: Chen
authors.affiliation: National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University of Medcine, Nanjing, China.
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Zhang
authors.affiliation: National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University of Medcine, Nanjing, China.
authors.forename: Yuan-Mao
authors.initials: YM
authors.lastname: Tu
authors.affiliation: National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University of Medcine, Nanjing, China.
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
references.citation: Clin J Am Soc Nephrol. 2008 Sep;3(5):1339-49
references.pmid: 18632851
references.citation: Am J Kidney Dis. 2011 Jan;57(1):170-4
references.pmid: 20974512
references.citation: BMC Nephrol. 2013 Jul 22;14:158
references.pmid: 23876025
references.citation: Eur J Haematol. 2001 Sep;67(3):158-64
references.pmid: 11737248
references.citation: Am J Kidney Dis. 1992 Jul;20(1):84-9
references.pmid: 1621685
references.citation: Clin Nephrol. 2002 Apr;57(4):303-9
references.pmid: 12005247
references.citation: Diagn Pathol. 2011 Sep 23;6:86
references.pmid: 21943175
references.citation: Nephrol Dial Transplant. 1996 Mar;11(3):535-6
references.pmid: 8671828
references.citation: Am J Clin Pathol. 2012 Sep;138(3):429-34
references.pmid: 22912361
references.citation: Kidney Int. 2006 Jun;69(12):2251-60
references.pmid: 16672913
references.citation: Kidney Int. 1992 Jul;42(1):127-35
references.pmid: 1635342
references.citation: Nephrol Dial Transplant. 1997 Apr;12(4):785-6
references.pmid: 9141013
references.citation: Hum Pathol. 2011 Jun;42(6):896-903
references.pmid: 21288559
references.citation: Nephrol Dial Transplant. 1997 Jul;12(7):1520-5
references.pmid: 9249805
references.citation: Haematologica. 2011 Jul;96(7):1002-7
references.pmid: 21486867
references.citation: Am J Kidney Dis. 2012 Dec;60(6):1044-8
references.pmid: 22835902
references.citation: Am J Kidney Dis. 2010 Dec;56(6):1191-6
references.pmid: 20843590
references.citation: Int J Hematol. 2009 May;89(4):533-537
references.pmid: 19322627
references.citation: Kidney Int. 1999 Jul;56(1):355-77
references.pmid: 10411717