title: Self-assembling amphiphilic peptides.
abstract: The self-assembly of several classes of amphiphilic peptides is reviewed, and selected applications are discussed. We discuss recent work on the self-assembly of lipopeptides, surfactant-like peptides and amyloid peptides derived from the amyloid-β peptide. The influence of environmental variables such as pH and temperature on aggregate nanostructure is discussed. Enzyme-induced remodelling due to peptide cleavage and nanostructure control through photocleavage or photo-cross-linking are also considered. Lastly, selected applications of amphiphilic peptides in biomedicine and materials science are outlined.
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
authors.forename: Ashkan
authors.initials: A
authors.lastname: Dehsorkhi
authors.forename: Valeria
authors.initials: V
authors.lastname: Castelletto
authors.forename: Ian W
authors.initials: IW
authors.lastname: Hamley
mesh_terms: D006801:Humans; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D057139:Nanofibers / Q000737:chemistry / Q000648:ultrastructure; D010446:Peptide Fragments / Q000737:chemistry*; D011485:Protein Binding; D015202:Protein Engineering; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D010446:Peptide Fragments; D013501:Surface-Active Agents
keywords: amphiphilic peptides; amyloid peptides; self-assembly; surfactant-like peptides
references.citation: Langmuir. 2006 Jan 31;22(3):1313-20
references.pmid: 16430299
references.citation: J Am Chem Soc. 2006 Jun 7;128(22):7291-8
references.pmid: 16734483
references.citation: Acta Biomater. 2010 Jan;6(1):3-11
references.pmid: 19635599
references.citation: ACS Nano. 2012 May 22;6(5):3907-18
references.pmid: 22468743
references.citation: Mol Pharm. 2013 Mar 4;10(3):1063-9
references.pmid: 23320752
references.citation: J Phys Chem B. 2009 Jul 23;113(29):9978-87
references.pmid: 19555054
references.citation: Nano Lett. 2005 Jul;5(7):1343-6
references.pmid: 16178235
references.citation: J Am Chem Soc. 2010 Jul 7;132(26):8819-21
references.pmid: 20552966
references.citation: ACS Nano. 2012 Sep 25;6(9):7956-65
references.pmid: 22928955
references.citation: Biochemistry. 2008 Oct 7;47(40):10630-6
references.pmid: 18783248
references.citation: Angew Chem Int Ed Engl. 2013 Sep 27;52(40):10537-40
references.pmid: 23955926
references.citation: Langmuir. 2013 Apr 9;29(14):4451-9
references.pmid: 23484851
references.citation: J Am Chem Soc. 2002 Dec 18;124(50):15030-7
references.pmid: 12475347
references.citation: J Am Chem Soc. 2008 Jul 30;130(30):9829-35
references.pmid: 18593163
references.citation: Soft Matter. 2013 Oct 28;9(40):9572-8
references.pmid: 26029764
references.citation: Langmuir. 2007 Apr 24;23(9):5033-8
references.pmid: 17373830
references.citation: ACS Macro Lett. 2013 Dec 17;2(12):1088-1094
references.pmid: 24490124
references.citation: J Am Chem Soc. 2013 Feb 27;135(8):2907-10
references.pmid: 23379791
references.citation: J Am Chem Soc. 2010 May 12;132(18):6306-8
references.pmid: 20397724
references.citation: J Phys Chem B. 2005 Jun 2;109(21):11027-32
references.pmid: 16852343
references.citation: J Biol Chem. 2002 Nov 8;277(45):43243-6
references.pmid: 12215440
references.citation: Eur J Biochem. 2004 May;271(9):1789-97
references.pmid: 15096218
references.citation: Soft Matter. 2006 Nov 15;2(12):1015-1024
references.pmid: 32680204
references.citation: Anal Chim Acta. 2009 May 8;641(1-2):95-100
references.pmid: 19393372
references.citation: J Am Chem Soc. 2003 May 28;125(21):6391-3
references.pmid: 12785778
references.citation: Biopolymers. 2007;88(2):115-21
references.pmid: 17154288
references.citation: Biochim Biophys Acta. 2006 Sep;1758(9):1184-202
references.pmid: 16756942
references.citation: Science. 2009 Jul 17;325(5938):328-32
references.pmid: 19541956
references.citation: J Am Chem Soc. 2011 Mar 2;133(8):2511-7
references.pmid: 21244023
references.citation: J Phys Chem B. 2008 Feb 28;112(8):2326-34
references.pmid: 18251531
references.citation: Faraday Discuss. 2013;166:381-97
references.pmid: 24611289
references.citation: Langmuir. 2012 Aug 21;28(33):12209-15
references.pmid: 22834769
references.citation: Langmuir. 2012 Apr 17;28(15):6386-95
references.pmid: 22439620
references.citation: FEBS Lett. 2010 May 3;584(9):1806-13
references.pmid: 19925791
references.citation: Angew Chem Int Ed Engl. 2009;48(13):2317-20
references.pmid: 19222067
references.citation: Bioorg Med Chem. 2013 Jun 15;21(12):3624-31
references.pmid: 23602621
references.citation: Biophys Chem. 2008 Nov;138(1-2):29-35
references.pmid: 18818009
references.citation: J Nanosci Nanotechnol. 2007 Jul;7(7):2246-52
references.pmid: 17663237
references.citation: FASEB J. 2002 Jan;16(1):77-83
references.pmid: 11772939
references.citation: Angew Chem Int Ed Engl. 2010 Jun 1;49(24):4104-7
references.pmid: 20425875
references.citation: Adv Healthc Mater. 2013 Oct;2(10):1388-400
references.pmid: 23554376
references.citation: Science. 2004 Feb 27;303(5662):1352-5
references.pmid: 14739465
references.citation: Biomacromolecules. 2013 Aug 12;14(8):2733-8
references.pmid: 23822204
references.citation: Amyloid. 2006 Dec;13(4):206-15
references.pmid: 17107881
references.citation: Biochemistry. 2014 Jan 21;53(2):300-10
references.pmid: 24377660
references.citation: ACS Nano. 2013 Jul 23;7(7):5965-77
references.pmid: 23758167
references.citation: J Phys Chem B. 2009 Jun 25;113(25):8539-44
references.pmid: 19534562
references.citation: Biopolymers. 2010;94(1):1-18
references.pmid: 20091874
references.citation: Langmuir. 2010 Jul 20;26(14):11624-7
references.pmid: 20666427
references.citation: Biomacromolecules. 2004 May-Jun;5(3):950-7
references.pmid: 15132686
references.citation: Chem Commun (Camb). 2007 Jul 14;(26):2729-31
references.pmid: 17594035
references.citation: J Biol Chem. 1997 May 9;272(19):12601-5
references.pmid: 9139713
references.citation: Chem Commun (Camb). 2013 Mar 4;49(18):1850-2
references.pmid: 23360959
references.citation: Dermatol Ther. 2007 Sep-Oct;20(5):343-9
references.pmid: 18045359
references.citation: Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13438-43
references.pmid: 21808036
references.citation: Angew Chem Int Ed Engl. 2007;46(43):8128-47
references.pmid: 17935097
references.citation: Protein Sci. 1993 Mar;2(3):404-10
references.pmid: 8453378
references.citation: Proc Natl Acad Sci U S A. 2007 May 8;104(19):7791-6
references.pmid: 17470802
references.citation: Curr Alzheimer Res. 2008 Jun;5(3):308-18
references.pmid: 18537545
references.citation: Biochim Biophys Acta. 2011 Jul;1808(7):1811-7
references.pmid: 21414289
references.citation: Langmuir. 2013 Nov 19;29(46):14246-53
references.pmid: 24156610
references.citation: Chem Soc Rev. 2004 May 10;33(4):234-45
references.pmid: 15103405
references.citation: Nano Lett. 2009 Mar;9(3):945-51
references.pmid: 19193022
references.citation: Chem Rev. 2012 Oct 10;112(10):5147-92
references.pmid: 22813427
references.citation: Langmuir. 2013 Jun 4;29(22):6665-72
references.pmid: 23651310
references.citation: Chem Biol Drug Des. 2010 Jun;75(6):563-9
references.pmid: 20374251
references.citation: J Phys Chem B. 2010 Jan 21;114(2):940-51
references.pmid: 20039666
references.citation: J Biol Chem. 1993 May 15;268(14):9941-4
references.pmid: 8486721
references.citation: Macromol Biosci. 2008 Nov 10;8(11):1060-7
references.pmid: 18814319
references.citation: Biomacromolecules. 2010 Feb 8;11(2):402-11
references.pmid: 20078032
references.citation: Int J Antimicrob Agents. 2004 Dec;24(6):536-47
references.pmid: 15555874
references.citation: Langmuir. 2012 May 1;28(17):7023-32
references.pmid: 22489967
references.citation: Langmuir. 2008 Aug 5;24(15):8158-62
references.pmid: 18572891
references.citation: Biochemistry. 2008 Apr 22;47(16):4597-605
references.pmid: 18370402
references.citation: ACS Nano. 2012 Dec 21;6(12):10776-85
references.pmid: 23153342
references.citation: Langmuir. 2012 Mar 20;28(11):5017-22
references.pmid: 22352406
references.citation: Soft Matter. 2011 Oct 21;7(20):9665-9672
references.pmid: 22408645
references.citation: Angew Chem Int Ed Engl. 2011 Jun 6;50(24):5495-8
references.pmid: 21538748
references.citation: Langmuir. 2011 Feb 1;27(3):1079-84
references.pmid: 21214195
references.citation: Soft Matter. 2007 Aug 14;3(9):1135-1137
references.pmid: 32900034
references.citation: Chem Commun (Camb). 2010 Dec 21;46(47):8938-40
references.pmid: 21046031
references.citation: Int J Cosmet Sci. 2011 Dec;33(6):483-90
references.pmid: 21535443
references.citation: Biochemistry. 2008 Sep 23;47(38):10018-26
references.pmid: 18759497
references.citation: Annu Rev Microbiol. 1995;49:277-304
references.pmid: 8561461
references.citation: Biomater Sci. 2014 Mar 3;2(3):362-369
references.pmid: 32481862
references.citation: Neurobiol Aging. 2006 Apr;27(4):570-5
references.pmid: 16481071
references.citation: J Neurosci. 2008 Apr 2;28(14):3814-23
references.pmid: 18385339
references.citation: J Am Chem Soc. 2009 Jul 29;131(29):10165-72
references.pmid: 19569651
references.citation: Nat Rev Microbiol. 2005 Mar;3(3):238-50
references.pmid: 15703760
references.citation: Soft Matter. 2012;8(24):6430-6433
references.pmid: 25593589
references.citation: Chem Soc Rev. 2010 Sep;39(9):3394-412
references.pmid: 20523948
references.citation: J Am Chem Soc. 2003 Jun 18;125(24):7146-7
references.pmid: 12797766
references.citation: Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):519-24
references.pmid: 23267112
references.citation: Angew Chem Int Ed Engl. 2006 May 12;45(20):3216-51
references.pmid: 16676373
references.citation: Langmuir. 2011 Mar 15;27(6):2723-30
references.pmid: 21309606
references.citation: Langmuir. 2013 Apr 23;29(16):5050-9
references.pmid: 23534557
references.citation: J Am Chem Soc. 2008 Mar 12;130(10):2946-7
references.pmid: 18278921
references.citation: J Mol Biol. 1992 Nov 20;228(2):460-73
references.pmid: 1453457
references.citation: Angew Chem Int Ed Engl. 2009;48(32):5946-9
references.pmid: 19582745
references.citation: Faraday Discuss. 2013;166:181-94
references.pmid: 24611276
references.citation: Chem Commun (Camb). 2012 Oct 9;48(78):9774-6
references.pmid: 22918197
references.citation: Chem Commun (Camb). 2006 Jun 14;(22):2332-4
references.pmid: 16733570
references.citation: Chemistry. 2008;14(36):11369-75
references.pmid: 18618539
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3293-8
references.pmid: 20133666
references.citation: J Am Chem Soc. 2005 Feb 2;127(4):1193-200
references.pmid: 15669858
references.citation: Chem Soc Rev. 2012 Sep 21;41(18):5933-49
references.pmid: 22695880
references.citation: ACS Nano. 2013 Feb 26;7(2):1016-26
references.pmid: 23289352
references.citation: Exp Dermatol. 2012 Aug;21(8):563-8
references.pmid: 22672743
references.citation: Angew Chem Int Ed Engl. 1998 Apr 3;37(6):688-749
references.pmid: 29711371
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Sep;80(3 Pt 1):031922
references.pmid: 19905161
references.citation: J Am Chem Soc. 2012 Feb 29;134(8):3647-50
references.pmid: 22309293
references.citation: J Mol Biol. 1991 Mar 5;218(1):149-63
references.pmid: 2002499
references.citation: Langmuir. 2012 Aug 7;28(31):11599-608
references.pmid: 22788380
references.citation: Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):315-20
references.pmid: 15630094
references.citation: Angew Chem Int Ed Engl. 2008;47(22):4062-9
references.pmid: 18412209
references.citation: Langmuir. 2010 Jul 6;26(13):11297-303
references.pmid: 20408518
references.citation: J Mol Biol. 2002 Jun 21;319(5):1279-90
references.pmid: 12079364
references.citation: Langmuir. 2013 Jul 23;29(29):9149-55
references.pmid: 23822110
references.citation: Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5355-60
references.pmid: 11929973
references.citation: Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5133-8
references.pmid: 11929981
references.citation: Chem Soc Rev. 2010 Sep;39(9):3480-98
references.pmid: 20498896
references.citation: Langmuir. 2012 Feb 21;28(7):3391-6
references.pmid: 22272929
references.citation: Chem Commun (Camb). 2010 Dec 28;46(48):9185-7
references.pmid: 21031196
references.citation: J Am Chem Soc. 2011 Mar 16;133(10):3677-83
references.pmid: 21341770
references.citation: Langmuir. 2011 Dec 6;27(23):14438-49
references.pmid: 21995651
references.citation: Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16883-8
references.pmid: 21969533
references.citation: Langmuir. 2013 Jul 9;29(27):8609-18
references.pmid: 23755822
references.citation: Nat Mater. 2009 Oct;8(10):773-4
references.pmid: 19773784
references.citation: Langmuir. 2011 Mar 15;27(6):2980-8
references.pmid: 21338121
references.citation: FEBS J. 2005 Dec;272(23):5971-8
references.pmid: 16302962
references.citation: Biomater Sci. 2013 Nov 1;1(11):1138-1142
references.pmid: 32481936