title: What a difference two days make: "personalized" embryo transfer (pET) paradigm: a case report and pilot study.
abstract: Embryo implantation requires that the blastocyst will attach during the receptive stage of the endometrium, known as window of implantation (WOI). Historically, it has been assumed that the WOI is always constant in all women. However, molecular analyses of endometrial receptivity demonstrates a personalized WOI (pWOI) that is displaced in one out of four patients suffering from recurrent implantation failure (RIF) of endometrial origin and illustrates the utility of a personalized endometrial diagnostic approach. Here, we report a clinical case of successful personalized embryo transfer (pET) after four IVF and three oocyte donation failed attempts in which different embryo transfer strategies were attempted. This case report is complemented by a pilot study of 17 patients undergoing oocyte donation and who suffered failed implantations with routine embryo transfer (ET) but were then treated with pET after the personalized diagnosis of their WOI.
authors.affiliation: IVIOMICS, Parc Cientific Valencia University, Paterna, Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Ruiz-Alonso
authors.forename: N
authors.initials: N
authors.lastname: Galindo
authors.forename: A
authors.initials: A
authors.lastname: Pellicer
authors.forename: C
authors.initials: C
authors.lastname: Simón
mesh_terms: D000328:Adult; D010064:Embryo Implantation / Q000502:physiology*; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008875:Middle Aged; D010865:Pilot Projects; D057285:Precision Medicine; D011247:Pregnancy; D018873:Pregnancy Rate; D013812:Therapeutics
keywords: assisted reproduction; personalized embryo transfer; recurrent implantation failure; window of implantation