title: Multifocal encephalopathy and autoimmune-mediated limbic encephalitis following tocilizumab therapy.
abstract: A 63-year-old man with rheumatoid arthritis developed multifocal encephalopathy and limbic encephalitis following therapy with tocilizumab, a humanized anti-interleukin-6 receptor antibody. Anti-glutamate receptor ε2 antibodies were later found to be positive in both the serum and cerebrospinal fluid. This case highlights the possibility of the development of encephalopathy after treatment with tocilizumab, which may also induce autoimmune limbic encephalitis.
authors.affiliation: Department of Neurology, Osaka Saiseikai Nakatsu Hospital, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Koji
authors.initials: K
authors.lastname: Furukawa
authors.forename: Toru
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Makio
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology; D001327:Autoimmune Diseases / Q000139:chemically induced*; D006801:Humans; D020363:Limbic Encephalitis / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D019947:Receptors, Interleukin-6 / Q000037:antagonists & inhibitors*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D019947:Receptors, Interleukin-6; D016194:Receptors, N-Methyl-D-Aspartate; C502936:tocilizumab