title: Effects of antibiotics administration on the incidence of wound infection in percutaneous dilatational tracheostomy.
abstract: The effect of antibiotics during the perioperative period of percutaneous dilatational tracheostomy (PDT) is still controversial. A total of 297 patients who underwent the PDT procedure were divided into 2 groups:those administered antibiotics perioperatively and those not administered antibiotics. Wound infections were noted in 7 cases (incidence rate, 2.36%) and no death was recorded. Of the 69 patients without antibiotics, 5 developed wound infections (incidence rate, 7.25%), while only 2 of the 228 patients with antibiotics developed wound infections (incidence rate, 0.88%) (p＝0.002;risk ratio, 8.82;95% confidence interval, 1.67-46.6). Of the 7 cases of wound infection, 5 cases occurred during the early period after PDT (within 7 days). Collectively, the present results suggest that prophylactic administration of antibiotics may prevent the incidence of PDT-induced wound infection, especially in the early phase after the PDT procedures. The need for antibiotics in PDT should be reconsidered.
authors.affiliation: Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.e_dai_for_all@hotmail.com.
authors.forename: Hideharu
authors.initials: H
authors.lastname: Hagiya
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Naito
authors.forename: Shingo
authors.initials: S
authors.lastname: Hagioka
authors.forename: Shuji
authors.initials: S
authors.lastname: Okahara
authors.forename: Naoki
authors.initials: N
authors.lastname: Morimoto
authors.forename: Nobuchika
authors.initials: N
authors.lastname: Kusano
authors.forename: Fumio
authors.initials: F
authors.lastname: Otsuka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D016638:Critical Illness; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D014139:Tracheostomy / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents