title: Anti-asthmatic activities of an ethanol extract of Aster yomena in an ovalbumin-induced murine asthma model.
abstract: Aster yomena is used in traditional remedies to treat cough, asthma and insect bites; however, its therapeutic mechanism is not completely understood. To elucidate the anti-asthmatic effect of A. yomena, we investigated the anti-asthmatic characteristics of an alcohol extract of A. yomena in an ovalbumin (OVA)-induced murine asthma model. In this study, we showed that A. yomena extract inhibited the overall pathophysiological features of asthma by suppressing Th2 responses and enzymes associated with the production of inflammatory mediators. This suppression resulted in decreased Th2 type cytokines and eosinophils in the bronchoalveolar lavage fluid and OVA-specific IgE in serum. Additionally, A. yomena extract significantly decreased airway hyperresponsiveness and abrogated the histopathological changes in the lungs, which reached normal levels in the OVA-challenged mice treated with A. yomena extract. These findings suggest that A. yomena could be a promising natural agent for treating bronchial asthma in humans.
authors.affiliation: 1 Department of Anatomy & Biomedical Sciences, Seoul National University College of Medicine , Seoul, Korea.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Sim
authors.forename: Hyun Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Sunkyung
authors.initials: S
authors.lastname: Lee
authors.forename: Dae Eun
authors.initials: DE
authors.lastname: Park
authors.forename: Keunhee
authors.initials: K
authors.lastname: Oh
authors.forename: Kyung-A
authors.initials: KA
authors.lastname: Hwang
authors.forename: Hye-Ryun
authors.initials: HR
authors.lastname: Kang
authors.forename: Sang-Kyu
authors.initials: SK
authors.lastname: Ye
authors.forename: Hang-Rae
authors.initials: HR
authors.lastname: Kim
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D031173:Aster Plant; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D016207:Cytokines / Q000032:analysis; D004195:Disease Models, Animal; D004804:Eosinophils; D000431:Ethanol; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018418:Th2 Cells / Q000276:immunology
chemical_list: D018927:Anti-Asthmatic Agents; D016207:Cytokines; D010936:Plant Extracts; D007073:Immunoglobulin E; D000431:Ethanol; D010047:Ovalbumin
keywords: Aster yomena; OVA-induced asthma; airway hyperresponsiveness
references.citation: Am J Respir Crit Care Med. 2008 Nov 15;178(10):1023-32
references.pmid: 18787221
references.citation: Ann Allergy Asthma Immunol. 2011 Aug;107(2):163-70
references.pmid: 21802025
references.citation: J Allergy Clin Immunol. 1991 Feb;87(2):540-8
references.pmid: 1993813
references.citation: Annu Rev Immunol. 1999;17:255-81
references.pmid: 10358759
references.citation: Comp Biochem Physiol C Toxicol Pharmacol. 2003 Oct;136(2):109-15
references.pmid: 14559292
references.citation: N Engl J Med. 2001 Feb 1;344(5):350-62
references.pmid: 11172168
references.citation: J Clin Pathol. 2001 Aug;54(8):577-89
references.pmid: 11477111
references.citation: J Allergy Clin Immunol. 2007 Apr;119(4):831-7
references.pmid: 17289133
references.citation: Mt Sinai J Med. 2011 Sep-Oct;78(5):697-716
references.pmid: 21913200
references.citation: Thorax. 2001 May;56(5):335-6
references.pmid: 11312397
references.citation: Am J Respir Crit Care Med. 2001 Oct 15;164(8 Pt 2):S1-5
references.pmid: 11704610
references.citation: Ann Allergy Asthma Immunol. 2011 Aug;107(2):154-62
references.pmid: 21802024
references.citation: Can Respir J. 2006 Sep;13(6):327-35
references.pmid: 16983448
references.citation: Nat Rev Drug Discov. 2002 Jan;1(1):55-64
references.pmid: 12119610
references.citation: J Allergy Clin Immunol. 2006 Jan;117(1):3-16; quiz 17
references.pmid: 16387577
references.citation: Curr Drug Targets. 2008 Jun;9(6):485-94
references.pmid: 18537587
references.citation: Evid Based Complement Alternat Med. 2012;2012:462383
references.pmid: 23243447