title: Biosynthesis and characterization of Acalypha indica mediated copper oxide nanoparticles and evaluation of its antimicrobial and anticancer activity.
abstract: Copper oxide nanoparticles were synthesized by biological method using aqueous extract of Acalypha indica leaf and characterized by UV-visible spectroscopy, XRD, FT-IR, SEM TEM and EDX analysis. The synthesised particles were highly stable, spherical and particle size was in the range of 26-30 nm. The antimicrobial activity of A.indica mediated copper oxide nanoparticles was tested against selected pathogens. Copper oxide nanoparticles showed efficient antibacterial and antifungal effect against Escherichia coli, Pseudomonas fluorescens and Candida albicans. The cytotoxicity activity of A.indica mediated copper nanoparticles was evaluated by MTT assay against MCF-7 breast cancer cell lines and confirmed that copper oxide nanoparticles have cytotoxicity activity.
authors.affiliation: School of Science and Engineering, Teesside University, Middlesbrough - TS1 3BA, Tees Valley, UK; Department of Biotechnology, School of Life Sciences, Karpagam University, Eachanari Post, Coimbatore 641 021, Tamil Nadu, India. Electronic address: rajeshwarishivaraj@gmail.com.
authors.forename: Rajeshwari
authors.initials: R
authors.lastname: Sivaraj
authors.affiliation: School of Science and Engineering, Teesside University, Middlesbrough - TS1 3BA, Tees Valley, UK.
authors.forename: Pattanathu K S M
authors.initials: PK
authors.lastname: Rahman
authors.affiliation: Department of Biotechnology, School of Life Sciences, Karpagam University, Eachanari Post, Coimbatore 641 021, Tamil Nadu, India.
authors.forename: P
authors.initials: P
authors.lastname: Rajiv
authors.affiliation: Department of Biotechnology, School of Life Sciences, Karpagam University, Eachanari Post, Coimbatore 641 021, Tamil Nadu, India.
authors.forename: S
authors.initials: S
authors.lastname: Narendhran
authors.affiliation: Faculty of Chemistry, Government Arts College, Udumalpet 642 126, Tamil Nadu, India.
authors.forename: R
authors.initials: R
authors.lastname: Venckatesh
mesh_terms: D065815:Acalypha / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D001943:Breast Neoplasms / Q000188:drug therapy; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D005260:Female; D055772:Green Chemistry Technology / Q000379:methods; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D010936:Plant Extracts; D003300:Copper; C000520:cuprous oxide
keywords: Acalypha indica; Antimicrobial; Biological method; Copper oxide nanoparticles; Cytotoxicity