title: One-pot synthesis of ureas from Boc-protected amines.
abstract: A practical one-pot synthesis of ureas is described. Boc-protected amines can be transformed into nonsymmetrical and symmetrical disubstituted and trisubstituted ureas utilizing 2-chloropyridine and trifluoromethanesulfonyl anhydride for the in situ generation of an isocyanate, which reacts with an amine. A variety of amines can be employed successfully, leading to high yields of isolated ureas.
authors.affiliation: Laboratory of Organic Chemistry, Department of Chemistry, University of Athens , Panepistimiopolis 15771, Athens, Greece.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Spyropoulos
authors.forename: Christoforos G
authors.initials: CG
authors.lastname: Kokotos
mesh_terms: D000588:Amines / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D008698:Mesylates; D011725:Pyridines; C083126:2-chloropyridine; D014508:Urea; C012077:trifluoromethanesulfonic acid