title: Benign perivascular myoid cell tumor (myopericytoma) of the urinary tract: a report of 2 cases with an emphasis on differential diagnosis.
abstract: Myopericytoma is a benign mesenchymal neoplasm thought to comprise part of a spectrum of perivascular myoid cell neoplasms with myofibroma, angioleiomyoma, and glomus tumor. We describe 2 such neoplasms involving the urinary tract: 1 incidentally identified in the kidney of a 59-year-old woman and 1 in the urinary bladder of a 52-year-old woman who presented with urinary frequency and dysuria. Histologically, the bladder tumor was composed of numerous blood vessels surrounded by plump perivascular myoid cells, as in subcutaneous myopericytoma. The renal tumor showed similar morphology centrally and a symplastic glomus tumor-like growth pattern at the periphery. Immunohistochemically, both tumors were reactive for markers of smooth muscle differentiation, such as smooth muscle actin and caldesmon/calponin but negative for CD34, cathepsin K, and S100 protein. Both patients are free of disease 14 and 39 months after resection, respectively. Our findings broaden the morphologic spectrum of myopericytoma.
authors.affiliation: Department of Pathology, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang 315100, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Pathology, Henry Ford Health System, Detroit, MI 48202, USA.
authors.forename: Sean R
authors.initials: SR
authors.lastname: Williamson
authors.affiliation: Department of Pathology, the First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, Zhejiang 310003, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Sun
authors.affiliation: Department of Pathology, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang 315100, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Pathology, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang 315100, China.
authors.forename: Changshui
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Radiology, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang 315100, China.
authors.forename: Wenping
authors.initials: W
authors.lastname: Xia
authors.affiliation: Department of Urology, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang 315100, China.
authors.forename: Honggang
authors.initials: H
authors.lastname: Qi
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Lisha
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Linos
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address: liang_cheng@yahoo.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
mesh_terms: D002135:Calcium-Binding Proteins / Q000032:analysis; D002148:Calmodulin-Binding Proteins / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008840:Microfilament Proteins / Q000032:analysis; D008875:Middle Aged; D009372:Neoplasms, Connective Tissue / Q000175:diagnosis* / Q000473:pathology; D020286:Pericytes / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology; D000096985:Calponins
chemical_list: D002135:Calcium-Binding Proteins; D002148:Calmodulin-Binding Proteins; D008840:Microfilament Proteins; D000096985:Calponins
keywords: Differential diagnosis; Glomus tumor; Immunohistochemistry; Kidney; Mesenchymal tumor; Myopericytoma; Urinary bladder