title: Effect of heavy-ion beam irradiation on the level of serum soluble interleukin-2 receptors in hamster cheek pouch carcinoma model.
abstract: Soluble interleukin-2 receptor (sIL-2R) is a glycoprotein derived from α chain of interleukin 2 receptors of mononuclear as well as T-cell membranes. The aims of this study were to detect the changes of serum soluble interleukin-2 receptor (sIL-2R) levels following heavy-ion beam irradiation in the hamster model with cheek pouch carcinoma, as well as to examine the impact of immune status of the hamster cheek pouch carcinoma model using heavy-ion beam irradiation. sIL-2R serum levels were detected by radioimmunoassay (RIA) in 40 hamsters bearing cheek pouch carcinoma prior to and following exposure to heavy-ion beam irradiation, and 8 normal animals served as the control. The sIL-2R serum level in hamster cheek pouch carcinoma model was significantly increased as compared to the normal control group (P<0.05). Results showed that an increase in the irradiation dose led to a gradual decrease in the sIL-2R serum level. Additionally, a statistical significance was observed compared to the tumor group (P<0.05). In conclusion, alterations in serum sIL-2R expression have an effect on the hamsters cheek pouch carcinoma model subsequent to heavy-ion beam irradiation. An increase in the irradiation dose indicated a decreased tendency in serum sIL-2R content. Detection of serum level changes may lead to an improved understanding of heavy-ion irradiationin vivoimmune status, which is crucial for clinical diagnosis and prognosis. It can also provide a sensitive indicator to help estimate the effects of heavy-ion cancer targets.
authors.affiliation: College of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: An
authors.affiliation: College of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
authors.forename: Mingxin
authors.initials: M
authors.lastname: Li
authors.affiliation: College of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: College of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Institute of Modern Physics, Chinese Academy of Science, Lanzhou, Gansu 730050, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Institute of Solid Mechanics, School of Civil Engineering and Mechanics, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
authors.forename: Jizeng
authors.initials: J
authors.lastname: Wang
keywords: cheek pouch carcinoma; heavy ion irradiation; immune status; soluble interleukin-2 receptors
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