title: Potassium permanganate-acridine yellow chemiluminescence system for the determination of fluvoxamine, isoniazid and ceftriaxone.
abstract: Based on the oxidation of acridine yellow by permanganate in basic medium, a new chemiluminescence system was developed for the sensitive determination of some important drugs. The remarkable inhibiting effect of fluvoxamine, ceftriaxone and isoniazid on this reaction was applied to their detection. A possible mechanism was proposed for this system based on chemiluminescence emission wavelengths and experimental observations. Under optimum conditions, calibration graphs were obtained for 1 × 10(-9) to 1 × 10(-6) mol/L of fluvoxamine; 2 × 10(-8) to 8 × 10(-6) mol/L of ceftriaxone and 5 × 10(-8) to 4 × 10(-5) mol/L of isoniazid. This proposed method was satisfactorily used in the determination of these drugs in pharmaceutical samples and human urine and serum.
authors.affiliation: Department of Chemistry, East Azerbaijan Science and Research Branch, Islamic Azad University, Tabriz, Iran.
authors.forename: Jafar
authors.initials: J
authors.lastname: Abolhasani
authors.forename: Javad
authors.initials: J
authors.lastname: Hassanzadeh
mesh_terms: D000609:Aminoacridines / Q000737:chemistry*; D002443:Ceftriaxone / Q000032:analysis* / Q000097:blood / Q000652:urine; D016666:Fluvoxamine / Q000032:analysis* / Q000097:blood / Q000652:urine; D006801:Humans; D007538:Isoniazid / Q000032:analysis* / Q000097:blood / Q000652:urine; D008163:Luminescent Measurements / Q000379:methods*; D011196:Potassium Permanganate / Q000737:chemistry*; D015203:Reproducibility of Results; D013607:Tablets / Q000032:analysis
chemical_list: D000609:Aminoacridines; D013607:Tablets; D011196:Potassium Permanganate; D002443:Ceftriaxone; D016666:Fluvoxamine; C025902:acridine yellow; D007538:Isoniazid
keywords: acridine yellow; chemiluminescence; drug; permanganate