title: [Multimodal management in soft tissue sarcoma of the trunk and extremities].
abstract: Soft tissue sarcoma (STS) is a rare, extremely heterogeneous group of malignant tumors of mesodermal origin. With an incidence of 1-5 per 100,000/year they account for only 1 % of all human malignancies. The STSs occur predominantly in the lower extremities and the trunk. To date 100 different histopathological subentities can be defined. The prognosis varies substantially depending on the localization and histology. Whereas local recurrence rates and overall survival of sarcomas of the extremities have benefited from the introduction of multimodal therapies, only marginal progress has been made in the management of trunk STSs. This manuscript gives an overview of preoperative diagnostics, pathology and neoadjuvant as well as adjuvant therapeutic options for soft tissue sarcoma.
authors.affiliation: Chirurgische Klinik (A), Allgemein-, Thorax-, Viszeral- und Kinderchirurgie, Universitätsklinikum, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.
authors.forename: M P H
authors.initials: MP
authors.lastname: Ghadimi
authors.forename: A
authors.initials: A
authors.lastname: Rehders
authors.forename: W T
authors.initials: WT
authors.lastname: Knoefel
mesh_terms: D000008:Abdominal Neoplasms / Q000473:pathology / Q000628:therapy*; D001918:Brachytherapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003299:Cooperative Behavior; D005121:Extremities; D006801:Humans; D006979:Hyperthermia, Induced; D033183:Interdisciplinary Communication; D020360:Neoadjuvant Therapy; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D016032:Randomized Controlled Trials as Topic; D012509:Sarcoma / Q000473:pathology / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000628:therapy*; D013899:Thoracic Neoplasms / Q000473:pathology / Q000628:therapy*
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