title: Seroprevalence of Japanese encephalitis virus infection in captive Japanese macaques (Macaca fuscata).
abstract: Japanese encephalitis virus (JEV), which is transmitted by mosquitoes, infects many animal species and causes serious acute encephalitis in humans and horses. In this study, a serosurvey of JEV in Japanese macaques (Macaca fuscata) reared in Aichi Prefecture was conducted using purified JEV as an antigen for ELISA. The results revealed that 146 of 332 monkeys (44 %) were seropositive for JEV. In addition, 35 of 131 monkeys (27 %) born in the facility were seropositive, and the annual infection rate in the facility was estimated as 13 %. Our results provide evidence of the frequent exposure of many Japanese macaques to JEV, suggesting that there is a risk of JEV transmission to humans by mosquitoes.
authors.affiliation: Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi, 753-8515, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimoda
authors.forename: Akatsuki
authors.initials: A
authors.lastname: Saito
authors.forename: Keita
authors.initials: K
authors.lastname: Noguchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Terada
authors.forename: Ryusei
authors.initials: R
authors.lastname: Kuwata
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Akari
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Takasaki
authors.forename: Ken
authors.initials: K
authors.lastname: Maeda
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D004664:Encephalitis Virus, Japanese / Q000302:isolation & purification*; D004672:Encephalitis, Japanese / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D006801:Humans; D008251:Macaca; D008297:Male; D008992:Monkey Diseases / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D018570:Risk Assessment; D016036:Seroepidemiologic Studies
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