title: Importance of N-glycosylation on CD147 for its biological functions.
abstract: Glycosylation of glycoproteins is one of many molecular changes that accompany malignant transformation. Post-translational modifications of proteins are closely associated with the adhesion, invasion, and metastasis of tumor cells. CD147, a tumor-associated antigen that is highly expressed on the cell surface of various tumors, is a potential target for cancer diagnosis and therapy. A significant biochemical property of CD147 is its high level of glycosylation. Studies on the structure and function of CD147 glycosylation provide valuable clues to the development of targeted therapies for cancer. Here, we review current understanding of the glycosylation characteristics of CD147 and the glycosyltransferases involved in the biosynthesis of CD147 N-glycans. Finally, we discuss proteins regulating CD147 glycosylation and the biological functions of CD147 glycosylation.
authors.affiliation: Cell Engineering Research Centre and Department of Cell Biology, State Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China. sydbaiyang@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Cell Engineering Research Centre and Department of Cell Biology, State Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China. huangwan@fmmu.edu.cn.
authors.forename: Wan
authors.initials: W
authors.lastname: Huang
authors.affiliation: Cell Engineering Research Centre and Department of Cell Biology, State Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China. malitian1234@163.com.
authors.forename: Li-Tian
authors.initials: LT
authors.lastname: Ma
authors.affiliation: Cell Engineering Research Centre and Department of Cell Biology, State Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China. jiangjl@fmmu.edu.cn.
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Jiang
authors.affiliation: Cell Engineering Research Centre and Department of Cell Biology, State Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China. zhinanchen@fmmu.edu.cn.
authors.forename: Zhi-Nan
authors.initials: ZN
authors.lastname: Chen
mesh_terms: D051926:Basigin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006031:Glycosylation; D016695:Glycosyltransferases / Q000378:metabolism; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D016297:Mutagenesis, Site-Directed; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D051926:Basigin; D016695:Glycosyltransferases; D020782:Matrix Metalloproteinases
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