title: Three new sesquiterpene lactones from Inula britannica.
abstract: One new 1,10-secoeudesmanolide (1), two eudesmanolides (2 and 3), together with nine known compounds (4-12) were isolated from the aerial parts of Inula britannica. The structures of the new compounds were elucidated by detailed spectroscopic analysis, including HRESIMS and 2D-NMR spectroscopic method. In addition, compounds 1-4 were tested for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
authors.forename: Xu-Feng
authors.initials: XF
authors.lastname: Zhang
authors.forename: Jing-Ling
authors.initials: JL
authors.lastname: Du
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Feng-Mei
authors.initials: FM
authors.lastname: Ye
authors.forename: Yang-Guo
authors.initials: YG
authors.lastname: Xie
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Cheng
authors.forename: Shi-Kai
authors.initials: SK
authors.lastname: Yan
authors.forename: Hui-Zi
authors.initials: HZ
authors.lastname: Jin
mesh_terms: D000818:Animals; D002460:Cell Line; D003461:Crystallography; D038143:Inula; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes