title: Severe adverse drug events under combination of nortriptyline and melperone due to pharmacokinetic interaction.
authors.affiliation: Department of Psychiatry and Psychotherapy University Medical CenterMainz, Germany gudrun.hefner@unimedizin-mainz.de Department of Psychiatry and Psychotherapy University Medical Center Mainz, Germany.
authors.forename: Gudrun
authors.initials: G
authors.lastname: Hefner
authors.forename: Katharina
authors.initials: K
authors.lastname: Geschke
authors.forename: Christoph
authors.initials: C
authors.lastname: Hiemke
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D002090:Butyrophenones / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D019389:Cytochrome P-450 CYP2D6 / Q000187:drug effects / Q000378:metabolism; D003866:Depressive Disorder / Q000188:drug therapy; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008875:Middle Aged; D009661:Nortriptyline / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D002090:Butyrophenones; D009661:Nortriptyline; D019389:Cytochrome P-450 CYP2D6; C008522:metylperon