title: Acute-onset chronic inflammatory demyelinating polyneuropathy with focal segmental glomerulosclerosis.
abstract: Inflammatory neuropathies have been reported to occur in association with nephrotic syndrome. Their underlying immuno-pathogenic mechanisms remain unknown. A 50-year-old woman concurrently presented with acute-onset chronic inflammatory demyelinating polyneuropathy and nephrotic syndrome secondary to focal segmental glomerulosclerosis. Both neuropathy and proteinuria improved after plasma exchange and steroids. Literature review of cases of concurrent inflammatory neuropathies and nephrotic syndrome revealed similar neuro-renal presentations. This neuro-renal condition may be mediated by autoantibodies targeting myelin and podocytes.
authors.affiliation: Department of Medicine, National University Health System, Singapore.
authors.forename: Amy May Lin
authors.initials: AM
authors.lastname: Quek
authors.affiliation: Department of Medicine, National University Health System, Singapore.
authors.forename: Derek
authors.initials: D
authors.lastname: Soon
authors.affiliation: Department of Medicine, National University Health System, Singapore.
authors.forename: Yee Cheun
authors.initials: YC
authors.lastname: Chan
authors.affiliation: Department of Pathology, National University Health System, Singapore.
authors.forename: Thomas Paulraj
authors.initials: TP
authors.lastname: Thamboo
authors.affiliation: Department of Medicine, National University Health System, Singapore. Electronic address: mdcyuki@nus.edu.sg.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
mesh_terms: D004558:Electric Stimulation; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D010525:Peripheral Nerves / Q000503:physiopathology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000150:complications* / Q000473:pathology; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors
keywords: Autoimmune disease; Chronic inflammatory demyelinating polyneuropathy; Focal segmental glomerulosclerosis; Guillain–Barré syndrome; Nephrotic syndrome; Peripheral neuropathy