title: Impact of serum omentin-1 levels on cardiac prognosis in patients with heart failure.
abstract: BACKGROUND
  Various adipokines are reported to be associated with the development of heart failure (HF) through insulin resistance and chronic inflammation. Omentin-1 is a novel adipokine and is associated with incident coronary artery disease. However, it remains unclear whether serum omentin-1 levels are associated with cardiac prognosis in patients with HF.
  
  
  METHODS
  We measured serum omentin-1 levels at admission in 136 consecutive patients with HF, and 20 control subjects without signs of significant heart disease. We prospectively followed patients with HF to endpoints of cardiac death or re-hospitalization for worsening HF.
  
  
  RESULTS
  Serum omentin-1 levels were markedly lower in HF patients with cardiac events compared with to without. The patients who were in New York Heart Association (NYHA) functional class IV showed significantly lower serum omentin-1 levels compared to those in class II and III, whereas serum omentin-1 levels did not correlate with serum brain natriuretic peptide levels (r = 0.217, P = 0.011). We divided the HF patients into three groups based on the tertiles of serum omentin-1 level (low T1, middle T2, and high T3). Multivariate Cox hazard analysis showed that the lowest serum omentin-1 level (T1) was independently associated with cardiac events after adjustment for confounding factors (hazard ratio 5.78, 95% confidence interval 1.20-12.79). We divided the HF patients into two groups according to the median serum omentin-1 levels. Kaplan-Meier analysis revealed that the patients with low serum omentin-1 levels had a higher risk of cardiac events compared with those with high serum omentin-1 levels (log-rank test p < 0.001).
  
  
  CONCLUSIONS
  Decreased serum omentin-1 levels were associated with a poor cardiac outcome in patients with HF.
authors.forename: Taro
authors.initials: T
authors.lastname: Narumi
authors.affiliation: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan. tewatana@med.id.yamagata-u.ac.jp.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Watanabe
authors.forename: Shinpei
authors.initials: S
authors.lastname: Kadowaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kinoshita
authors.forename: Miyuki
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Yuki
authors.initials: Y
authors.lastname: Honda
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Otaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishiyama
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Takanori
authors.initials: T
authors.lastname: Arimoto
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Shishido
authors.forename: Takuya
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D058851:GPI-Linked Proteins / Q000097:blood; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins
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