title: Hypoparathyroidism and subclinical hypothyroidism with secondary hemochromatosis.
abstract: Hemochromatosis is an inherited genetic disorder of iron metabolism which can also occur as a secondary result of iron-overload. It leads to organ damage such as cardiomyopathy, liver cirrhosis, hypogonadism, and diabetes. This paper discusses a case of secondary hemochromatosis associated with repeated transfusions, presenting as asymptomatic hypoparathyroidism and subclinical hypothyroidism with multiple organ involvement. The 29-year-old female, who had severe aplastic anemia, received multiple transfusions totaling approximately 1,400 units of red blood cells over 15 years. During her routine laboratory examination, hypocalcemia was detected with decreased intact parathyroid hormone and increased thyroid stimulating hormone. Serum ferritin, iron, and total iron binding capacity had increased to 27,583.03 ng/mL, 291 µg/dL, and 389 µg/dL, respectively. She had unusually bronze skin and computed tomography revealed iron deposition in the thyroid, liver, and heart. Multiorgan involvement as seen in this case is rare in hemochromatosis associated with secondary transfusions. To the best of the author's knowledge, this is the first case report in Korea of hypoparathyroidism and subclinical hypothyroidism due to iron deposition in the parathyroid and thyroid gland.
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Hwasun, Korea.
authors.forename: Hyung Ki
authors.initials: HK
authors.lastname: Jeong
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Hwasun, Korea.
authors.forename: Joon Hwan
authors.initials: JH
authors.lastname: An
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Hwasun, Korea.
authors.forename: Hyoung Sang
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Hwasun, Korea.
authors.forename: Eun Ae
authors.initials: EA
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Hwasun, Korea.
authors.forename: Min Gui
authors.initials: MG
authors.lastname: Han
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Hwasun, Korea.
authors.forename: Jung Sik
authors.initials: JS
authors.lastname: Moon
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Hwasun, Korea.
authors.forename: Hee Kyung
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Hwasun, Korea.
authors.forename: Ho-Cheol
authors.initials: HC
authors.lastname: Kang
keywords: Hemochromatosis; Hypoparathyroidism; Hypothyroidism
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