title: [Pyrethroid resistance mechanisms in the body lice Pediculus humanus humanus L.: detoxification enzyme systems].
abstract: Synergists (piperonyl butoxide, MGK-264 (N-octyl bicycloheptene dicarboximide), DEF (S, S, S, tributyl phosphorotrithioate), and diethylmaleate) were used to investigate the metabolic resistance of body lice to permethrin. Instances of the synergistic activity ofpermethrin when combined with enzyme system inhibitors have been identified. The synergic ratios were 3.3 to 52.0 for monooxygenase inhibitors; 5.2 to 7.4 for esterases, and about 4 for glutathione-S-transferases. Since the use of the synergists did not lead to full inhibition of resistance, it was concluded that the lice had also a kdr-like type of resistance.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Lopatina
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Eremina
authors.forename: É A
authors.initials: ÉA
authors.lastname: Iakovlev
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors; D006703:Ill-Housed Persons; D006801:Humans; D007305:Insecticide Resistance / Q000502:physiology; D007306:Insecticides; D054833:Isoindoles; D010373:Lice Infestations / Q000469:parasitology*; D008298:Maleates; D009636:Norbornanes; D063086:Organothiophosphates; D010374:Pediculus / Q000201:enzymology* / Q000254:growth & development; D026023:Permethrin; D010574:Pesticide Synergists; D010882:Piperonyl Butoxide
chemical_list: D004791:Enzyme Inhibitors; D007306:Insecticides; D054833:Isoindoles; D008298:Maleates; D009636:Norbornanes; D063086:Organothiophosphates; D010574:Pesticide Synergists; C004371:N-(2-ethylhexyl)-5-norbornene-2,3-dicarboxamide; D026023:Permethrin; C006863:butyl phosphorotrithioate; C014476:diethyl maleate; D010882:Piperonyl Butoxide