title: Surgical treatment of mammary carcinomas in dogs with or without postoperative chemotherapy.
abstract: This retrospective study identified prognostic factors associated with survival; and compared survival data in 94 canine mammary carcinoma (MCA) dogs treated with surgery (n = 58), or surgery and adjunct chemotherapy (n = 36), and a subset of dogs with poor prognostic factors. On multivariate analysis independent predictors of median survival time (MST) were clinical stage, lymphatic invasion (LI; present 179 days; none 1098 days), ulceration (present 118 days; none 443 days) and surgical margins (incomplete 70 days; complete 872 days). Complete surgical margins were associated with MST in dogs with stages 1-3 MCA (incomplete 68 days; complete 1098 days) and dogs with LI (incomplete 70 days; complete 347 days). There was no statistically significant improvement in MST in dogs with advanced disease (stage 4 or LI) treated with adjunctive chemotherapy (chemotherapy 228 days; none 194 days); although five dogs with complete surgical margins that received mitoxantrone and carboplatin had a mean survival of 1139 days.
authors.affiliation: Animal Referral Hospital, Sydney, New South Wales, Australia.
authors.forename: C M
authors.initials: CM
authors.lastname: Tran
authors.affiliation: Veterinary Oncology Consultants, Wauchope, New South Wales, Australia.
authors.forename: A S
authors.initials: AS
authors.lastname: Moore
authors.affiliation: Veterinary Oncology Consultants, Wauchope, New South Wales, Australia.
authors.forename: A E
authors.initials: AE
authors.lastname: Frimberger
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002277:Carcinoma / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D017024:Chemotherapy, Adjuvant / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D004285:Dogs; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: cancer; canine; mammary cancer; mammary tumour; oncology; small animal