title: Determination of tissue thermal conductivity by measuring and modeling temperature rise induced in tissue by pulsed focused ultrasound.
abstract: A tissue thermal conductivity (Ks) is an important parameter which knowledge is essential whenever thermal fields induced in selected organs are predicted. The main objective of this study was to develop an alternative ultrasonic method for determining Ks of tissues in vitro suitable for living tissues. First, the method involves measuring of temperature-time T(t) rises induced in a tested tissue sample by a pulsed focused ultrasound with measured acoustic properties using thermocouples located on the acoustic beam axis. Measurements were performed for 20-cycle tone bursts with a 2 MHz frequency, 0.2 duty-cycle and 3 different initial pressures corresponding to average acoustic powers equal to 0.7 W, 1.4 W and 2.1 W generated from a circular focused transducer with a diameter of 15 mm and f-number of 1.7 in a two-layer system of media: water/beef liver. Measurement results allowed to determine position of maximum heating located inside the beef liver. It was found that this position is at the same axial distance from the source as the maximum peak-peak pressure calculated for each nonlinear beam produced in the two-layer system of media. Then, the method involves modeling of T(t) at the point of maximum heating and fitting it to the experimental data by adjusting Ks. The averaged value of Ks determined by the proposed method was found to be 0.5±0.02 W/(m·°C) being in good agreement with values determined by other methods. The proposed method is suitable for determining Ks of some animal tissues in vivo (for example a rat liver).
authors.affiliation: Department of Ultrasound, Institute of Fundamental Technological Research, Polish Academy of Sciences,Warsaw, Poland.
authors.forename: Tamara
authors.initials: T
authors.lastname: Kujawska
authors.affiliation: Department of Ultrasound, Institute of Fundamental Technological Research, Polish Academy of Sciences,Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Secomski
authors.affiliation: Department of Ultrasound, Institute of Fundamental Technological Research, Polish Academy of Sciences,Warsaw, Poland.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Kruglenko
authors.affiliation: Department of Ultrasound, Institute of Fundamental Technological Research, Polish Academy of Sciences,Warsaw, Poland.
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Krawczyk
authors.affiliation: Department of Ultrasound, Institute of Fundamental Technological Research, Polish Academy of Sciences,Warsaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Nowicki
mesh_terms: D000818:Animals; D008962:Models, Theoretical; D051381:Rats; D014463:Ultrasonography / Q000295:instrumentation* / Q000379:methods*
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