title: Urinary 8-hydroxy-2'-deoxyguanosine (8-oxodG) level can predict acute renal damage in young children with urinary tract infection.
abstract: BACKGROUND
  There are no good biomarkers to predict renal parenchymal involvement in children with urinary tract infection (UTI).
  
  
  METHODS
  Children (N = 73) younger than 5 years with UTI were enrolled. Urinary levels of 8-hydroxy-2'-deoxyguanosine (8-oxodG) and total antioxidant capacity (TAC) were checked as markers of oxidative stress and antioxidant capacity, respectively. Tc99m-dimercaptosuccinic acid (DMSA) renal scintigraphy was used to find evidence of renal involvement.
  
  
  RESULTS
  Patients with positive DMSA findings had higher levels of urinary 8-oxodG (p = 0.003) and higher urinary TAC (p = 0.001) than patients with normal DMSA findings.
  
  
  CONCLUSIONS
  High level of urinary 8-oxodG may be a risk factor of severe renal damage.
authors.affiliation: Departments of Pediatrics .
authors.forename: Jien-Wen
authors.initials: JW
authors.lastname: Chien
authors.forename: Lien-Yen
authors.initials: LY
authors.lastname: Wang
authors.forename: Yu-Shan
authors.initials: YS
authors.lastname: Cheng
authors.forename: Yi-Giien
authors.initials: YG
authors.lastname: Tsai
authors.forename: Chin-San
authors.initials: CS
authors.lastname: Liu
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D015415:Biomarkers / Q000652:urine*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology*; D008297:Male; D018384:Oxidative Stress; D014552:Urinary Tract Infections / Q000473:pathology / Q000652:urine*
chemical_list: D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine
keywords: 8-hydroxy-2′-deoxyguanosine; Tc99m-dimercaptosuccinic acid; total antioxidant capacity; urinary tract infection