title: Determination of drugs and drug-like compounds in different samples with direct analysis in real time mass spectrometry.
abstract: Direct analysis in real time (DART), a relatively new ionization source for mass spectrometry, ionizes small-molecule components from different kinds of samples without any sample preparation and chromatographic separation. The current paper reviews the published data available on the determination of drugs and drug-like compounds in different matrices with DART-MS, including identification and quantitation issues. Parameters that affect ionization efficiency and mass spectra composition are also discussed.
authors.affiliation: Research and Educational Center of the Peoples' Friendship University of Russia, Miklucho-Maklay st., Bldg. 8/2, 117198 Moscow, Russia. chern_es@mail.ru.
authors.forename: Elena S
authors.initials: ES
authors.lastname: Chernetsova
authors.forename: Gertrud E
authors.initials: GE
authors.lastname: Morlock
mesh_terms: D000818:Animals; D061891:Controlled Substances / Q000032:analysis*; D015507:Drugs, Investigational / Q000032:analysis*; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis*; D055553:Prescription Drugs / Q000032:analysis*; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D013997:Time Factors
chemical_list: D061891:Controlled Substances; D015507:Drugs, Investigational; D013287:Illicit Drugs; D055553:Prescription Drugs
keywords: DART; ambient mass spectrometry; direct analysis in real time; drugs; identification; quantitation