title: Supramolecular aggregates formed by sulfadiazine and sulfisomidine inclusion complexes with α- and β-cyclodextrins.
abstract: Sulfadiazine (SDA) and sulfisomidine (SFM) inclusion complexes with two cyclodextrins (α-CD and β-CD) are studied in aqueous as well as in solid state. The inclusion complexes are characterized by UV-visible, fluorescence, time correlated single photon counting, FTIR, DSC, PXRD and (1)H NMR techniques. The self assembled SDA/CD and SFM/CD inclusion complexes form different types of nano and microstructures. The self assembled nanoparticle morphologies are studied using SEM and TEM techniques. SDA/α-CD complex is formed hierarchal morphology, SDA/β-CD and SFM/β-CD complexes form the nanosheet self assembly. However, SFM/α-CD complex forms nanoporous sheet self assembly. van der Waals, hydrophobic and hydrogen bonding interaction play a vital role in the self assembling process.
authors.affiliation: Department of Chemistry, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India. Electronic address: drrajendiran@rediffmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Rajendiran
authors.affiliation: Department of Chemistry, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.
authors.forename: G
authors.initials: G
authors.lastname: Venkatesh
authors.affiliation: Department of Chemistry, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.
authors.forename: J
authors.initials: J
authors.lastname: Saravanan
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry*; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D013057:Spectrum Analysis; D013411:Sulfadiazine / Q000008:administration & dosage / Q000737:chemistry*; D013443:Sulfisomidine / Q000008:administration & dosage / Q000737:chemistry*; D047391:alpha-Cyclodextrins / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; D013411:Sulfadiazine; D013443:Sulfisomidine
keywords: Cyclodextrins; Inclusion complex; Nanomaterial; Nanosheet; Self assembly; Sulfa drugs