title: On-line reaction monitoring and mechanistic studies by mass spectrometry: Negishi cross-coupling, hydrogenolysis, and reductive amination.
abstract: Reaction monitoring using inductive ESI mass spectrometry allows chemical reactions to be tracked in real time, including air- and moisture-sensitive as well as heterogeneous reactions. Highly concentrated solutions can also be monitored for long periods without emitter clogging. Sheath gas assists in nebulization and a sample splitter reduces the delay time and minimizes contamination of the instrument. Short-lived intermediates (ca. 5 s) were observed in Pd/C-catalyzed hydrogenolysis, and several intermediates were seen in Negishi cross-coupling reactions.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, IN 47907 (USA).
authors.forename: Xin
authors.initials: X
authors.lastname: Yan
authors.forename: Ewa
authors.initials: E
authors.lastname: Sokol
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Guangtao
authors.initials: G
authors.lastname: Li
authors.forename: Shiqing
authors.initials: S
authors.lastname: Xu
authors.forename: R Graham
authors.initials: RG
authors.lastname: Cooks
mesh_terms: D000586:Amination; D002384:Catalysis; D013058:Mass Spectrometry; D010165:Palladium / Q000737:chemistry*
chemical_list: D010165:Palladium
keywords: air-/moisture-sensitive reactions; cross-coupling; mass spectrometry; reaction intermediates; reaction kinetics