title: Oral health and dental late adverse effects in children in remission from malignant disease. A pilot case-control study in Italian children.
abstract: OBJECTIVE
  To investigate with a reliable method the oral features in Italian patients in remission from cancer, highlighting the relationship with age at cancer therapy and to compare the data with healthy controls.
  
  
  METHODS
  Twenty five childhood cancer survivors treated under the age of 10 years with chemotherapy w/wo Haemopoietic Stem Cell Transplantation and/or head-neck Radiotherapy, in remission from cancer for at least 3 years, were examined for dental caries and enamel defects. To assess dental age and dental abnormalities a panoramic radiograph was taken. Patients were grouped according to age at cancer therapy (<3 years: subgroup Y; 3.1-5 years: subgroup M; >5 years: subgroup O). A control group of 26 healthy children was included.
  
  
  RESULTS
  There was not a statistically significant difference in caries prevalence between the two groups. A statistically significant difference between the two groups was found for enamel defects, dental abnormalities and dental age. The chi-squared test revealed a relationship between age at therapy and specific dental abnormalities.
  
  
  CONCLUSIONS
  This study shows that cancer therapy may increase the risk of development of enamel defects and dental abnormalities, especially in children treated under the age of 3 years.
authors.affiliation: Department of Biomedical and NeuroMotor Sciences (DiBiNeM), Unit of Dental Care for Special Needs Patients and Paediatric Dentistry, University of Bologna, Bologna, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bagattoni
authors.affiliation: Department of Biomedical and NeuroMotor Sciences (DiBiNeM), Unit of Dental Care for Special Needs Patients and Paediatric Dentistry, University of Bologna, Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: D'Alessandro
authors.affiliation: Unit of Paediatric Oncology, Sant'Orsola Hospital University of Bologna, Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Prete
authors.affiliation: Department of Biomedical and NeuroMotor Sciences (DiBiNeM), Unit of Dental Care for Special Needs Patients and Paediatric Dentistry, University of Bologna, Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Piana
authors.affiliation: Unit of Paediatric Oncology, Sant'Orsola Hospital University of Bologna, Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pession
mesh_terms: D000293:Adolescent; D000366:Age Determination by Teeth; D000367:Age Factors; D000848:Anodontia / Q000209:etiology; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D002648:Child; D004245:DMF Index; D003731:Dental Caries / Q000209:etiology; D003743:Dental Enamel / Q000002:abnormalities; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007558:Italy; D008297:Male; D020360:Neoadjuvant Therapy; D009805:Odontogenesis / Q000502:physiology; D009909:Oral Health; D010865:Pilot Projects; D011862:Radiography, Panoramic; D017741:Survivors; D014071:Tooth Abnormalities / Q000209:etiology; D014076:Tooth Diseases / Q000209:etiology*; D014092:Tooth Root / Q000002:abnormalities; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents