title: Does reactive thrombocytosis observed in iron deficiency anemia affect plasma viscosity?
abstract: OBJECTIVE
  The accompanying thrombocytosis is referred to as the major factor associated with thromboembolism in iron deficiency anemia (IDA). Increased viscosity may increase the risk of thrombosis. We hypothesized that increased platelet count -with reactive thrombocytosis- might also affect plasma viscosity. We planned to evaluate the influence of normal and high platelet count on plasma viscosity in IDA patients.
  
  
  METHODS
  The patient population consisted of fifty-three newly diagnosed and untreated women aged between 18 and 62 years with IDA. Group 1 consisted of 33 patients, platelet levels below 400 x 10(9)/L. Group 2 consisted of 20 patients, platelet levels above 400 x 10(9)/L. Measurements of plasma viscosity were performed using Brookfield viscometer.
  
  
  RESULTS
  Mean plasma viscosity was found as 1.05 ± 0.08 mPa.s. in Group 1, and 1.03 ± 0.06 mPa.s. in Group 2. Mean plasma viscosity was not statistically different. White blood cell count was significantly higher in Group 2. Vitamin B12 levels were significantly higher in Group 2, while folic acid levels were higher in Group 1 (p=0.011 and p=0.033). Plasma viscosity was correlated with erythrocyte sedimentation rate (r=0.512 p=0.002) in Group 1 and inversely correlated with vitamin B12 (r=-0.480 p=0.032) in Group 2.
  
  
  CONCLUSIONS
  Despite the significant difference between groups in terms of platelet count, no significant difference was detected in plasma viscosity and this finding could be explained as the following; 1-These platelets were not thrombocythemic platelets; 2-Similar to the theory about leukocytes, higher platelet counts - even non-thrombocythemic - may increase plasma viscosity; 3-Evaluating platelet count alone is not sufficient and the associating red-cell deformability should also be taken into account; and 4-Although other diseases that could affect viscosity are excluded, some definitely proven literature criteria such as fibrinogen, hyperlipidemia, and the inflammatory process should also be evaluated by laboratory and clinical measures.
authors.affiliation: Başkent University, School of Medicine, Department of Hematology, Ankara, Turkey.
authors.forename: Selami K
authors.initials: SK
authors.lastname: Toprak
authors.affiliation: Medicana International Ankara Hospital Cancer Center, Ankara, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Tek
authors.affiliation: Başkent University, School of Medicine, Department of Hematology, Ankara, Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Karakuş
authors.affiliation: Başkent University, School of Medicine, Department of Hematology, Ankara, Turkey.
authors.forename: Nihat
authors.initials: N
authors.lastname: Gök
authors.affiliation: Ankara University, School of Medicine, Department of Biostatistics, Ankara, Turkey.
authors.forename: Nazmiye
authors.initials: N
authors.lastname: Kurşun
keywords: Iron deficiency anemia; Plasma viscosity; Reactive thrombocytosis; Thrombocythemia
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