title: Thalamus and posterior temporal lobe show greater inter-network connectivity at rest and across sensory paradigms in schizophrenia.
abstract: Although a number of recent studies have examined functional connectivity at rest, few have assessed differences between connectivity both during rest and across active task paradigms. Therefore, the question of whether cortical connectivity patterns remain stable or change with task engagement continues to be unaddressed. We collected multi-scan fMRI data on healthy controls (N=53) and schizophrenia patients (N=42) during rest and across paradigms arranged hierarchically by sensory load. We measured functional network connectivity among 45 non-artifactual distinct brain networks. Then, we applied a novel analysis to assess cross paradigm connectivity patterns applied to healthy controls and patients with schizophrenia. To detect these patterns, we fit a group by task full factorial ANOVA model to the group average functional network connectivity values. Our approach identified both stable (static effects) and state-based differences (dynamic effects) in brain connectivity providing a better understanding of how individuals' reactions to simple sensory stimuli are conditioned by the context within which they are presented. Our findings suggest that not all group differences observed during rest are detectable in other cognitive states. In addition, the stable differences of heightened connectivity between multiple brain areas with thalamus across tasks underscore the importance of the thalamus as a gateway to sensory input and provide new insight into schizophrenia.
authors.affiliation: Computer Science Department, University of New Mexico, Albuquerque, NM 87131, United States. Electronic address: musicet37@gmail.com.
authors.forename: Mustafa S
authors.initials: MS
authors.lastname: Çetin
authors.affiliation: Mathematics Department, University of New Mexico, Albuquerque, NM 87131, United States.
authors.forename: Fletcher
authors.initials: F
authors.lastname: Christensen
authors.affiliation: Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Abbott
authors.affiliation: The Mind Research Network, Albuquerque, NM 87106, United States.
authors.forename: Julia M
authors.initials: JM
authors.lastname: Stephen
authors.affiliation: The Mind Research Network, Albuquerque, NM 87106, United States; Psychology Department, University of New Mexico, Albuquerque, NM 87131, United States; Neurology Department, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Mayer
authors.affiliation: Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States; Psychiatry Research Program, New Mexico VA Health Care System, Albuquerque, NM 87108, United States; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States.
authors.forename: José M
authors.initials: JM
authors.lastname: Cañive
authors.affiliation: Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States.
authors.forename: Juan R
authors.initials: JR
authors.lastname: Bustillo
authors.affiliation: Departments of Psychiatry & Neurobiology, Yale University, New Haven, CT 06511, United States.
authors.forename: Godfrey D
authors.initials: GD
authors.lastname: Pearlson
authors.affiliation: Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States; The Mind Research Network, Albuquerque, NM 87106, United States; Electrical and Computer Engineering Department, University of New Mexico, Albuquerque, NM 87131, United States.
authors.forename: Vince D
authors.initials: VD
authors.lastname: Calhoun
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D000368:Aged; D001307:Auditory Perception / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology*; D010775:Photic Stimulation; D012146:Rest / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012677:Sensation / Q000502:physiology*; D055139:Sensory Gating / Q000502:physiology; D013702:Temporal Lobe / Q000503:physiopathology*; D013788:Thalamus / Q000503:physiopathology*; D055815:Young Adult
keywords: Connectivity; Posterior temporal areas; Schizophrenia; Static & dynamic connectivity; Thalamus; fMRI
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