title: Proteomics, metabolomics, and protein interactomics in the characterization of the molecular features of major depressive disorder.
abstract: Omics technologies emerged as complementary strategies to genomics in the attempt to understand human illnesses. In general, proteomics technologies emerged earlier than those of metabolomics for major depressive disorder (MDD) research, but both are driven by the identification of proteins and/or metabolites that can delineate a comprehensive characterization of MDD's molecular mechanisms, as well as lead to the identification of biomarker candidates of all types-prognosis, diagnosis, treatment, and patient stratification. Also, one can explore protein and metabolite interactomes in order to pinpoint additional molecules associated with the disease that had not been picked up initially. Here, results and methodological aspects of MDD research using proteomics, metabolomics, and protein interactomics are reviewed, focusing on human samples.
authors.affiliation: Laboratory of Neuroproteomics, Department of Biochemistry, Institute of Biology, State University of Campinas (UNICAMP), Campinas, Brazil; Department of Psychiatry and Psychotherapy, Ludwig Maximilians University (LMU), Munich, Germany; Laboratory of Neurosciences (LIM-27), Institute of Psychiatry, University of São Paulo (USP), São Paulo, Brazil.
authors.forename: Daniel
authors.initials: D
authors.lastname: Martins-de-Souza
mesh_terms: D000818:Animals; D003865:Major Depressive Disorder / Q000503:physiopathology*; D006801:Humans; D055432:Metabolomics / Q000379:methods* / Q000639:trends; D040901:Proteomics / Q000379:methods* / Q000639:trends
keywords: CSF; NMR; biomarker; blood; brain; depression; interactomics; major depression; mass spectrometry; metabolomics; proteomics
references.citation: Neurochem Res. 2009 Jun;34(6):1021-9
references.pmid: 18979198
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1037-48
references.pmid: 20580919
references.citation: Arch Intern Med. 2000 Jul 24;160(14):2101-7
references.pmid: 10904452
references.citation: J Psychopharmacol. 2012 Dec;26(12):1569-83
references.pmid: 23139383
references.citation: Bioinformatics. 2011 Feb 1;27(3):431-2
references.pmid: 21149340
references.citation: Biochemistry. 2013 Jun 4;52(22):3829-40
references.pmid: 23442130
references.citation: Neuropsychopharmacology. 2012 Mar;37(4):1013-25
references.pmid: 22169944
references.citation: Int J Neuropsychopharmacol. 2012 Nov;15(10):1413-25
references.pmid: 22717272
references.citation: Proteomics Clin Appl. 2011 Feb;5(1-2):38-49
references.pmid: 21280236
references.citation: Drug Chem Toxicol. 2002 Nov;25(4):375-82
references.pmid: 12378948
references.citation: Clin Chim Acta. 2010 Feb;411(3-4):204-9
references.pmid: 19913000
references.citation: J Proteome Res. 2012 Dec 7;11(12):6223-30
references.pmid: 23110693
references.citation: Int Rev Neurobiol. 2011;101:65-94
references.pmid: 22050849
references.citation: Biol Psychiatry. 2011 Dec 1;70(11):1074-82
references.pmid: 21791337
references.citation: J Biochem Biophys Methods. 1982 Sep;6(4):317-39
references.pmid: 7142660
references.citation: J Proteomics. 2011 Feb 1;74(2):186-98
references.pmid: 21055488
references.citation: J Biol Chem. 2011 Jul 22;286(29):25435-42
references.pmid: 21632543
references.citation: Curr Opin Struct Biol. 2011 Apr;21(2):200-8
references.pmid: 21320770
references.citation: Curr Opin Microbiol. 2009 Oct;12(5):553-8
references.pmid: 19744879
references.citation: Proteomics. 2012 Feb;12(4-5):736-47
references.pmid: 22247077
references.citation: J Biol Chem. 1975 May 25;250(10):4007-21
references.pmid: 236308
references.citation: Drug Discov Today. 2005 May 1;10(9):653-62
references.pmid: 15894230
references.citation: Behav Brain Res. 2011 Jul 7;220(2):305-11
references.pmid: 21316396
references.citation: Mol Cell Proteomics. 2007 Jul;6(7):1226-38
references.pmid: 17426018
references.citation: Methods Mol Biol. 2010;662:29-58
references.pmid: 20824465
references.citation: Mol Cell Proteomics. 2010 Jul;9(7):1578-93
references.pmid: 20368287
references.citation: Electrophoresis. 1988 Jan;9(1):37-46
references.pmid: 2466646
references.citation: Mol Biosyst. 2012 Feb;8(2):470-81
references.pmid: 22041788
references.citation: Can J Psychiatry. 2002 May;47(4):315-26
references.pmid: 12025430
references.citation: Biol Psychiatry. 2014 Oct 1;76(7):e15-7
references.pmid: 24607422
references.citation: Mol Psychiatry. 2000 Mar;5(2):142-9
references.pmid: 10822341
references.citation: Electrophoresis. 2013 Jan;34(1):86-98
references.pmid: 23161106
references.citation: Dis Markers. 2013;35(1):1-2
references.pmid: 24167343
references.citation: Nucleic Acids Res. 2013 Jan;41(Database issue):D808-15
references.pmid: 23203871
references.citation: Expert Opin Emerg Drugs. 2012 Mar;17(1):105-26
references.pmid: 22339643
references.citation: J Proteome Res. 2012 Mar 2;11(3):1741-8
references.pmid: 22239730
references.citation: Anal Biochem. 2009 Jul 1;390(1):29-37
references.pmid: 19298787
references.citation: Nat Biotechnol. 2001 Jan;19(1):45-50
references.pmid: 11135551
references.citation: Bioanalysis. 2012 Jun;4(10):1235-43
references.pmid: 22651567
references.citation: Eur Arch Psychiatry Clin Neurosci. 2012 Mar;262(2):167-72
references.pmid: 21553311
references.citation: Electrophoresis. 1997 Oct;18(11):2071-7
references.pmid: 9420172
references.citation: J Proteome Res. 2011 Jan 7;10(1):120-5
references.pmid: 20939596
references.citation: Sci Rep. 2012;2:667
references.pmid: 22993692
references.citation: F1000 Biol Rep. 2012;4:14
references.pmid: 22802875
references.citation: Eur Arch Psychiatry Clin Neurosci. 2010 Oct;260(7):561-2
references.pmid: 20155362
references.citation: Ann Rheum Dis. 2008 Dec;67 Suppl 3:iii70-4
references.pmid: 19022819
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Feb 1;883-884:68-75
references.pmid: 22074957
references.citation: Transl Psychiatry. 2013 Jan 22;3:e223
references.pmid: 23340506
references.citation: PLoS One. 2010 Feb 11;5(2):e9166
references.pmid: 20161799
references.citation: Int J Geriatr Psychiatry. 2007 May;22(5):418-23
references.pmid: 17048218
references.citation: Proteomics. 2008 Dec;8(23-24):4862-72
references.pmid: 19003865
references.citation: Neuroscience. 2013 Sep 5;247:191-200
references.pmid: 23727007
references.citation: Eur Arch Psychiatry Clin Neurosci. 2012 Dec;262(8):657-66
references.pmid: 22350622
references.citation: Mass Spectrom Rev. 2007 Jan-Feb;26(1):51-78
references.pmid: 16921475
references.citation: Curr Psychiatry Rep. 2012 Dec;14(6):643-9
references.pmid: 22996298
references.citation: Mol Cell Proteomics. 2004 Dec;3(12):1154-69
references.pmid: 15385600
references.citation: Proteomics. 2006 Jun;6(11):3414-25
references.pmid: 16637010
references.citation: Transl Psychiatry. 2012 Mar 13;2:e87
references.pmid: 22832852
references.citation: Nat Biotechnol. 1999 Oct;17(10):994-9
references.pmid: 10504701
references.citation: Pharmacopsychiatry. 2011 May;44 Suppl 1:S54-61
references.pmid: 21544746
references.citation: Methods Mol Biol. 2011;708:191-204
references.pmid: 21207291
references.citation: Biotechnology (N Y). 1996 Jan;14(1):61-5
references.pmid: 9636313
references.citation: PLoS Med. 2006 Nov;3(11):e428
references.pmid: 17090210
references.citation: Expert Rev Proteomics. 2012;9(1):97-108
references.pmid: 22292827
references.citation: Nat Biotechnol. 1999 Jul;17(7):676-82
references.pmid: 10404161
references.citation: Mol Cell Proteomics. 2002 May;1(5):376-86
references.pmid: 12118079
references.citation: Mol Neurobiol. 2011 Jun;43(3):180-91
references.pmid: 21271304
references.citation: Xenobiotica. 1999 Nov;29(11):1181-9
references.pmid: 10598751
references.citation: Antioxid Redox Signal. 2011 Oct 1;15(7):2067-79
references.pmid: 20673161
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:268-76
references.pmid: 23085509
references.citation: BMC Neurosci. 2009 Nov 13;10:132
references.pmid: 19912621
references.citation: J Psychiatr Res. 2011 Jul;45(7):973-9
references.pmid: 21255794
references.citation: Anal Chim Acta. 2012 Oct 31;750:82-97
references.pmid: 23062430
references.citation: Mass Spectrom Rev. 2010 Sep-Oct;29(5):671-84
references.pmid: 19557839
references.citation: Anal Bioanal Chem. 2007 Sep;389(2):461-73
references.pmid: 17583802
references.citation: Neuro Endocrinol Lett. 2006 Jun;27(3):297-305
references.pmid: 16807525
references.citation: Mol Cell Proteomics. 2011 Dec;10(12):M111.008110
references.pmid: 21862759
references.citation: Neuropsychopharmacology. 2009 Jan;34(1):173-86
references.pmid: 18843269
references.citation: Biotechnol Prog. 2006 Jul-Aug;22(4):1003-11
references.pmid: 16889377
references.citation: Mol Cell Proteomics. 2013 Jan;12(1):207-14
references.pmid: 23111923
references.citation: Dis Markers. 2013;35(1):33-41
references.pmid: 24167347
references.citation: Anal Chem. 2010 Aug 1;82(15):6660-6
references.pmid: 20669998
references.citation: Int J Neuropsychopharmacol. 2012 Nov;15(10):1373-4
references.pmid: 22717368
references.citation: World J Biol Psychiatry. 2010 Aug;11(5):719-28
references.pmid: 20446881
references.citation: J Proteome Res. 2013 May 3;12(5):2101-15
references.pmid: 23464991
references.citation: Curr Opin Struct Biol. 2002 Jun;12(3):368-73
references.pmid: 12127457
references.citation: J Geriatr Psychiatry Neurol. 2010 Jun;23(2):138-46
references.pmid: 20101071
references.citation: Biochem Soc Trans. 2010 Aug;38(4):875-8
references.pmid: 20658969
references.citation: J Ethnopharmacol. 2010 Mar 24;128(2):482-9
references.pmid: 20079416
references.citation: Transl Psychiatry. 2011;1:
references.pmid: 22162828
references.citation: J Biochem Biophys Methods. 1983 Dec;8(4):321-30
references.pmid: 6663005
references.citation: Mol Biosyst. 2010 May;6(5):852-61
references.pmid: 20567771
references.citation: Eur Neuropsychopharmacol. 2009 Dec;19(12):868-75
references.pmid: 19664909
references.citation: BMC Syst Biol. 2011;5 Suppl 3:S12
references.pmid: 22784618
references.citation: Croat Med J. 2012 Dec;53(6):529-34
references.pmid: 23275318