title: Immunological alterations and associated diseases in mandrills (Mandrillus sphinx) naturally co-infected with SIV and STLV.
abstract: Mandrills are naturally infected with simian T-cell leukaemia virus type 1 (STLV-1) and simian immunodeficiency virus (SIV)mnd. In humans, dual infection with human immunodeficiency virus (HIV) and human T-cell lymphotropic virus type 1 (HTLV-1) may worsen their clinical outcome. We evaluated the effect of co-infection in mandrills on viral burden, changes in T-cell subsets and clinical outcome. The SIV viral load was higher in SIV-infected mandrills than in co-infected animals, whereas the STLV-1 proviral load was higher in co-infected than in mono-infected groups. Dually infected mandrills had a statistically significantly lower CD4+ T-cell count, a lower proportion of naive CD8+ T cells and a higher proportion of central memory cells. CD4(+) and CD8(+) T cells from SIV-infected animals had a lower percentage of Ki67 than those from the other groups. Co-infected monkeys had higher percentages of activated CD4(+) and CD8(+) T cells. Two co-infected mandrills with high immune activation and clonal integration of STLV provirus showed pathological manifestations (infective dermatitis and generalised scabies) rarely encountered in nonhuman primates.
authors.affiliation: Laboratoire de Rétrovirologie, Centre International de Recherches Médicales de Franceville, Franceville, Gabon.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Souquière
authors.affiliation: Laboratoire de Rétrovirologie, Centre International de Recherches Médicales de Franceville, Franceville, Gabon.
authors.forename: Maria
authors.initials: M
authors.lastname: Makuwa
authors.affiliation: Centre de Primatologie, Centre International de Recherches Médicales de Franceville, Franceville, Gabon.
authors.forename: Bettina
authors.initials: B
authors.lastname: Sallé
authors.affiliation: Département d׳Hématologie, Hôpital Necker, Paris, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Lepelletier
authors.affiliation: Université de Lyon 1, CNRS UMR5239, Oncovirologie et Biothérapies, Faculté de Médecine Lyon Sud, Pierre Bénite, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Mortreux
authors.affiliation: Département d׳Hématologie, Hôpital Necker, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
authors.affiliation: Laboratoire de Rétrovirologie, Centre International de Recherches Médicales de Franceville, Franceville, Gabon; Réseau International des Instituts Pasteur, Institut Pasteur, Paris, France. Electronic address: mirdad.kazanji@pasteur.fr.
authors.forename: Mirdad
authors.initials: M
authors.lastname: Kazanji
mesh_terms: D000818:Animals; D060085:Coinfection / Q000150:complications / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D006800:Deltaretrovirus Infections / Q000150:complications / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D048528:Mandrillus; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology* / Q000473:pathology / Q000821:virology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D019562:Viral Load
keywords: Associated diseases; Cell line; Co-infection; Immune system; Mandrillus sphinx; SIV; STLV; Viral load