title: Factors affecting health-related quality of life and physical activity after liver transplantation for autoimmune and nonautoimmune liver diseases: a prospective, single centre study.
abstract: OBJECTIVE
  With the improvement of the outcomes after liver transplantation (LTx), health-related quality of life (HRQoL) and physical activity are becoming significant outcome parameters. We prospectively assessed these parameters in patients with autoimmune and nonautoimmune liver disorders undergoing LTx.
  
  
  METHODS
  Patients (n = 107) were subdivided into 3 groups depending on the time after LTx: group-A (n = 21): 6-12 months; group-B (n = 48): 13-36 months; and group-C (n = 38): >37 months. SF-36 and IPAQ were applied in HRQoL and physical activity assessment.
  
  
  RESULTS
  Females had impaired HRQoL in most SF-36 domains. Younger patients showed higher scores at SF-36 physical functioning domain but IPAQ was not influenced by age. Group-B had higher general health and physical component summary than group-A (P = 0.037, P = 0.04, resp.) and total IPAQ than group-C (P = 0.047). The sitting time domain was longer in group-A than in group-B and group-C (P = 0.0157;  P = 0.042, resp.). Employed patients had better HRQoL and higher physical activity than those not working. SF-36 and IPAQ were unrelated to the autoimmune etiology of liver disease.
  
  
  CONCLUSIONS
  These findings show that female and unemployed patients have worse HRQoL, while gender and age at LTx time do not affect IPAQ's physical activity. The autoimmune etiology of liver disease does not influence HRQoL and physical activity after LTx.
authors.affiliation: Department of Physical Culture and Health Promotion, University of Szczecin, 70 067 Szczecin, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kotarska
authors.affiliation: Liver Research Laboratories, Pomeranian Medical University, 70 111 Szczecin, Poland.
authors.forename: Ewa
authors.identifier: 0000-0001-8740-5243
authors.initials: E
authors.lastname: Wunsch
authors.affiliation: Medical Biology Laboratory, Pomeranian Medical University, 70 111 Szczecin, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kempińska-Podhorodecka
authors.affiliation: Liver Research Laboratories, Pomeranian Medical University, 70 111 Szczecin, Poland ; Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery of the Medical University of Warsaw 02 097 Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Raszeja-Wyszomirska
authors.affiliation: Institute of Liver Studies, Division of Liver Transplantation and Mucosal Biology, King's College London School of Medicine, Denmark Hill Campus, London SE5 9RS, UK.
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Bogdanos
authors.affiliation: Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery of the Medical University of Warsaw 02 097 Warsaw, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Wójcicki
authors.affiliation: Liver Research Laboratories, Pomeranian Medical University, 70 111 Szczecin, Poland ; Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery of the Medical University of Warsaw 02 097 Warsaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Milkiewicz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy; D005260:Female; D006304:Health Status; D006801:Humans; D008107:Liver Diseases / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D011446:Prospective Studies; D011788:Quality of Life; D012737:Sex Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D013997:Time Factors
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