title: Awareness of cancer susceptibility genetic testing: the 2000, 2005, and 2010 National Health Interview Surveys.
abstract: BACKGROUND
  Genetic testing for several cancer susceptibility syndromes is clinically available; however, existing data suggest limited population awareness of such tests.
  
  
  OBJECTIVE
  To examine awareness regarding cancer genetic testing in the U.S. population aged ≥25 years in the 2000, 2005, and 2010 National Health Interview Surveys.
  
  
  METHODS
  The weighted percentages of respondents aware of cancer genetic tests, and percent changes from 2000-2005 and 2005-2010, overall and by demographic, family history, and healthcare factors were calculated. Interactions were used to evaluate the patterns of change in awareness between 2005 and 2010 among subgroups within each factor. To evaluate associations with awareness in 2005 and 2010, percentages were adjusted for covariates using multiple logistic regression. The analysis was performed in 2012.
  
  
  RESULTS
  Awareness decreased from 44.4% to 41.5% (p<0.001) between 2000 and 2005, and increased to 47.0% (p<0.001) in 2010. Awareness increased between 2005 and 2010 in most subgroups, particularly among individuals in the South (pinteraction=0.03) or with a usual place of care (pinteraction=0.01). In 2005 and 2010, awareness was positively associated with personal or family cancer history and high perceived cancer risk, and inversely associated with racial/ethnic minorities, age 25-39 or ≥60 years, male gender, lower education and income levels, public or no health insurance, and no provider contact in 12 months.
  
  
  CONCLUSIONS
  Despite improvement from 2005 to 2010, ≤50% of the U.S. adult population was aware of cancer genetic testing in 2010. Notably, disparities persist for racial/ethnic minorities and individuals with limited health care access or income.
authors.affiliation: Division of Cancer Epidemiology and Genetics, NIH, Bethesda, Maryland. Electronic address: maip@mail.nih.gov.
authors.forename: Phuong L
authors.initials: PL
authors.lastname: Mai
authors.affiliation: Health Outcomes and Behavior Program, Moffitt Cancer Center and Department of Oncologic Sciences, College of Medicine, University of South Florida, Tampa, Florida.
authors.forename: Susan Thomas
authors.initials: ST
authors.lastname: Vadaparampil
authors.affiliation: Health Services and Economics Branch, Applied Research Program, National Cancer Institute, Office of the Director, Division of Basic Neuroscience and Behavioral Research, NIH, Bethesda, Maryland.
authors.forename: Nancy
authors.initials: N
authors.lastname: Breen
authors.affiliation: Information Management Services, Inc., Calverton, Maryland.
authors.forename: Timothy S
authors.initials: TS
authors.lastname: McNeel
authors.affiliation: National Institute on Drug Abuse, NIH, Bethesda, Maryland.
authors.forename: Louise
authors.initials: L
authors.lastname: Wideroff
authors.affiliation: Division of Cancer Epidemiology and Genetics, NIH, Bethesda, Maryland.
authors.forename: Barry I
authors.initials: BI
authors.lastname: Graubard
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001364:Awareness; D005260:Female; D005820:Genetic Testing / Q000706:statistics & numerical data*; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000208:ethnology; D044469:Racial Groups; D018570:Risk Assessment; D012737:Sex Factors; D012959:Socioeconomic Factors; D014481:United States
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