title: A fullerene-based multi-functional nanoplatform for cancer theranostic applications.
abstract: Recently, nanomaterials with multiple functions, such as drug carrier, MRI and optical imaging, photothermal therapy etc, have become more and more popular in the domain of cancer research. In this study, a C60-IONP nanocomposite is synthesized via decorating iron oxide nanoparticles (IONP) onto fullerene (C60) and then functionalized by polyethylene glycol (PEG2000), giving C60-IONP-PEG with excellent stability in physiological solutions, finally folic acid (FA), a widely used tumor targeting molecule, was linked to C60-IONP-PEG in order to obtain an active tumor targeting effect to MCF-7 cells and malignant tumor in mice models. Herein, a hybrid nanoplatform with multi-functional characteristics for cancer diagnosis, photodynamic therapy (PDT), radiofrequency (RF) thermal therapy (RTT) and magnetic targeting applications was developed and explored its biofunctions in vitro and in vivo. C60-IONP-PEG-FA showed neglectable toxicity, not only served as a powerful tumor diagnostic magnetic resonance imaging (MRI) contrast agent, but also as a strong photosensitizer and powerful agent for photothermal ablation of tumor, furthermore a remarkable synergistic enhancement of PDT combination with RTT was also observed during the treatment both in vitro and in vivo. Moreover, the multi-functional nanoplatform also could selectively kill cancer cells in highly localized regions via the excellent active tumor targeting and magnetic targeted abilities. This work showed the multi-functional C60-IONP-PEG-FA nanoplatform had a great potential for cancer theranostic applications.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Shi
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Rou
authors.initials: R
authors.lastname: Ma
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Ruiyuan
authors.initials: R
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China. Electronic address: zhangzz08@126.com.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D005492:Folic Acid / Q000737:chemistry / Q000627:therapeutic use; D037741:Fullerenes / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007036:Hypothermia, Induced; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D010778:Photochemotherapy; D011092:Polyethylene Glycols / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D037741:Fullerenes; D058185:Magnetite Nanoparticles; D011092:Polyethylene Glycols; D005492:Folic Acid
keywords: Magnetic targeting; Multifunction; Theranostic nanoplatform; Tumor targeting