title: Beneficial effects of breastfeeding in women with gestational diabetes mellitus.
abstract: Gestational diabetes mellitus (GDM) increases the future risk of developing type 2 diabetes mellitus (T2DM). There is now a growing evidence that breastfeeding has short- and long-term health benefits for mothers with GDM. Mothers with GDM who breastfeed have improved lipid and glucose metabolic profiles for the first 3 months after birth. However, women with GDM are less likely to breastfeed and, if they do, breastfeeding is usually continued for a shorter duration compared with women without GDM. One long-term prospective study followed women with GDM from delivery for up to 19 years postpartum, and found that breastfeeding for ≥3 months reduced the risk of T2DM and delayed the development of T2DM by a further 10 years compared with breastfeeding for <3 months. However, the physiological mechanisms underlying the protective effects of breastfeeding are still unknown, even though it is important to gain a full understanding of the pathways involved in these effects. Therefore, the purpose of this review is to provide a comprehensive analysis of the recent developments in the field of GDM and breastfeeding. We reviewed data from animal experiments and human studies. We also provide insight into the molecular pathways and describe promising topics for future research.
authors.affiliation: Institute of Diabetes Research, Helmholtz Zentrum München, Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany ; Forschergruppe Diabetes e.V., Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Much
authors.affiliation: Institute of Diabetes Research, Helmholtz Zentrum München, Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany ; Forschergruppe Diabetes e.V., Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Beyerlein
authors.affiliation: Institute of Diabetes Research, Helmholtz Zentrum München, Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany ; Forschergruppe Diabetes e.V., Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
authors.forename: Michaela
authors.initials: M
authors.lastname: Roßbauer
authors.affiliation: Institute of Diabetes Research, Helmholtz Zentrum München, Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany ; Forschergruppe Diabetes e.V., Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Hummel
authors.affiliation: Institute of Diabetes Research, Helmholtz Zentrum München, Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany ; Forschergruppe Diabetes e.V., Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
authors.forename: Anette-G
authors.initials: AG
authors.lastname: Ziegler
keywords: Breastfeeding; Gestational diabetes mellitus; Glucose homeostasis; Type 2 diabetes mellitus
references.citation: Am J Public Health. 2010 Jun;100(6):1047-52
references.pmid: 20395581
references.citation: Am J Physiol. 1986 Nov;251(5 Pt 1):E537-41
references.pmid: 3535531
references.citation: Diabetes Care. 2012 Jan;35(1):50-6
references.pmid: 22011407
references.citation: Endocrinology. 1982 Feb;110(2):600-6
references.pmid: 6276141
references.citation: Am J Clin Nutr. 2014 Jan;99(1):115-21
references.pmid: 24196401
references.citation: Br J Nutr. 2004 Dec;92(6):905-12
references.pmid: 15613252
references.citation: Obstet Gynecol. 2013 Dec;122(6):1263-70
references.pmid: 24201684
references.citation: J Am Coll Nutr. 2005 Oct;24(5):320-6
references.pmid: 16192255
references.citation: Lancet. 1984 Dec 1;2(8414):1283
references.pmid: 6150315
references.citation: Ir Med J. 2012 May;105(5 Suppl):31-6
references.pmid: 22838108
references.citation: BMC Public Health. 2011 Dec 23;11:952
references.pmid: 22196129
references.citation: Am J Epidemiol. 1986 Sep;124(3):353-8
references.pmid: 3740036
references.citation: Am J Prev Med. 2013 Sep;45(3):253-61
references.pmid: 23953350
references.citation: Science. 2007 Nov 2;318(5851):806-9
references.pmid: 17975067
references.citation: Metabolism. 2001 Jun;50(6):715-9
references.pmid: 11398150
references.citation: J Clin Endocrinol Metab. 2001 Mar;86(3):989-93
references.pmid: 11238474
references.citation: Diabetes. 1995 May;44(5):586-91
references.pmid: 7729620
references.citation: Neuroendocrinology. 2012;95(4):332-43
references.pmid: 22441304
references.citation: Obstet Gynecol. 1993 Sep;82(3):451-5
references.pmid: 8355952
references.citation: Horm Metab Res. 1997 May;29(5):220-4
references.pmid: 9228206
references.citation: Obstet Gynecol. 2012 Jul;120(1):136-43
references.pmid: 22914402
references.citation: Diabetes Care. 1997 Jul;20(7):1183-97
references.pmid: 9203460
references.citation: Am J Clin Nutr. 1999 Feb;69(2):299-307
references.pmid: 9989696
references.citation: Dtsch Med Wochenschr. 2008 Feb;133(5):180-4
references.pmid: 18213549
references.citation: Osteoporos Int. 1993 Mar;3(2):76-83
references.pmid: 8453194
references.citation: Diabetes Care. 2010 Aug;33(8):1798-804
references.pmid: 20484133
references.citation: Diabetes. 1995 May;44(5):506-12
references.pmid: 7729607
references.citation: Am J Clin Nutr. 1993 Jul;58(1):54-60
references.pmid: 8317390
references.citation: Diabetes. 2012 Dec;61(12):3167-71
references.pmid: 23069624
references.citation: Lancet. 2009 May 23;373(9677):1773-9
references.pmid: 19465232
references.citation: Biochem J. 1984 Jun 1;220(2):455-60
references.pmid: 6146315
references.citation: Diabetes. 1999 Dec;48(12):2430-6
references.pmid: 10580433
references.citation: Diabetes. 1994 Feb;43(2):263-73
references.pmid: 7904577
references.citation: Obes Rev. 2009 Mar;10(2):194-203
references.pmid: 19055539
references.citation: JAMA. 1998 Aug 12;280(6):533-8
references.pmid: 9707143
references.citation: Endocrinology. 2002 Apr;143(4):1378-85
references.pmid: 11897695
references.citation: JAMA. 2005 Nov 23;294(20):2601-10
references.pmid: 16304074
references.citation: Am J Clin Nutr. 2012 May;95(5):1113-35
references.pmid: 22456657
references.citation: JAMA. 1996 Apr 17;275(15):1165-70
references.pmid: 8609683
references.citation: J Endocrinol. 2003 Feb;176(2):193-203
references.pmid: 12553868
references.citation: Diabetes Care. 1997 Nov;20(11):1717-23
references.pmid: 9353615
references.citation: Diabetes. 1984 Jul;33(7):667-73
references.pmid: 6203798
references.citation: Lancet. 2008 May 24;371(9626):1723
references.pmid: 18502275
references.citation: Nat Med. 2010 Jul;16(7):804-8
references.pmid: 20581837
references.citation: Arch Pediatr Adolesc Med. 1998 Mar;152(3):249-54
references.pmid: 9529462
references.citation: Pediatrics. 2004 May;113(5):e465-71
references.pmid: 15121990
references.citation: Diabetes. 2002 Sep;51(9):2796-803
references.pmid: 12196473
references.citation: Metabolism. 1990 Nov;39(11):1127-32
references.pmid: 2233272
references.citation: Eur J Endocrinol. 2011 Dec;165(6):953-9
references.pmid: 21937504
references.citation: Diabet Med. 2013 Sep;30(9):1094-101
references.pmid: 23692476
references.citation: Eur J Endocrinol. 2013 Mar 15;168(4):515-23
references.pmid: 23302255
references.citation: Am J Physiol. 1990 Dec;259(6 Pt 1):E828-34
references.pmid: 2175552
references.citation: Horm Metab Res. 2011 Aug;43(9):593-600
references.pmid: 21823053
references.citation: Diabetes. 2010 Feb;59(2):495-504
references.pmid: 19959762
references.citation: Diabetes. 2003 Jan;52(1):102-10
references.pmid: 12502499