title: The role of the transcription factor KLF2 in vascular development and disease.
abstract: The zinc-finger transcription factor KLF2 transduces the physical forces exerted by blood flow into molecular signals responsible for a wide range of biological responses. Following its initial recognition as a flow-responsive endothelial transcription factor, KLF2 is now known to be expressed in a range of cell types and to participate in a number of processes during development and disease such as endothelial homeostasis, vasoregulation, vascular growth/remodeling, and inflammation. In this review, we summarize the current understanding about KLF2 with a focus on its effects on vascular biology.
authors.affiliation: MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Sheffield, United Kingdom; Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: Novodvorsky
authors.affiliation: MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Sheffield, United Kingdom; Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Timothy J A
authors.initials: TJ
authors.lastname: Chico
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000196:embryology* / Q000378:metabolism*; D018056:Hemorheology; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D040542:Mechanotransduction, Cellular; D008954:Models, Biological; D014652:Vascular Diseases / Q000378:metabolism* / Q000473:pathology
chemical_list: D051741:Kruppel-Like Transcription Factors
keywords: Angiogenesis; Atherosclerosis; Endothelium; KLF2; Shear stress; Valvulogenesis; Vasculogenesis