title: The infarct location predicts the outcome of single small subcortical infarction in the territory of the middle cerebral artery.
abstract: BACKGROUND
  Single small subcortical infarction (SSSI) in the territory of the middle cerebral artery (MCA) may be classified as proximal SSSI (pSSSI) or distal SSSI (dSSSI) according to its extension to the MCA. We sought to investigate the outcome of different types of SSSIs.
  
  
  METHODS
  We assessed 177 patients who had an SSSI (67 pSSSI and 110 dSSSI) in the perforator territory of MCA. The clinical characteristics, neurologic status (initial National Institutes of Health Stroke Scale score at admission and modified Rankin Scale [mRS] score at 1 year), and clinical treatments at 1 year were evaluated.
  
  
  RESULTS
  Among the 177 patients, 130 had favorable (mRS score≤1) and 41 had unfavorable outcome (mRS score≥2) at 1 year, dSSSI had higher mRS than pSSSI at 1 year (1 [0-2] versus 0 [0-1]; P=.013). The age (odds ratio [OR] 1.049, 95% confidence interval [CI] 1.002-1.098; P=.041) and distal location of the lesion (OR 2.687, 95% CI 1.039-6.948; P=.042) were found to be independent risk factors of 1-year unfavorable outcome of SSSIs.
  
  
  CONCLUSIONS
  SSSI has a heterogeneous outcome at 1 year according to the lesion location.
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Pu
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Xinying
authors.initials: X
authors.lastname: Zou
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Yuesong
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of Imaging and Interventional Radiology, Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Defeng
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Ka S
authors.initials: KS
authors.lastname: Wong
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address: yongjunwang1962@gmail.com.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D002544:Cerebral Infarction / Q000473:pathology*; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000473:pathology*; D012307:Risk Factors
keywords: Single small subcortical infarction; lesion location; outcome