title: Potential antidiabetic activity of extracellular polysaccharides in submerged fermentation culture of Coriolus versicolor LH1.
abstract: The separation and purification of extracellular polysaccharides from Coriolus versicolor LH1 were investigated along with their α-glucosidase inhibition properties. Three polysaccharide fractions (ePS-F2-1, ePS-F3-1, and ePS-F4-1) were separated from the culture medium of LH1 using a DEAE anion-exchange column and a Sephadex™ G-50 gel filtration column. Their chemical compositions was determined. On the basis of an α-glucosidase inhibition assay, the enzyme inhibition activities of ePS-F2-1, ePS-F3-1, and ePS-F4-1 were investigated. Among these, ePS-F4-1 had the highest enzyme inhibition effects on α-glucosidase. According to the results of the chemical component analysis, ePS-F3-1 and ePS-F4-1 are the polysaccharides which are combined with triterpenoides, and ePS-F2-1 is complexed with proteins and triterpenoides.
authors.affiliation: Natural Products Chemistry Research Laboratory, Department of Bioindustry Technology, Dayeh University, Changhua 51591, Taiwan.
authors.forename: John Powen
authors.initials: JP
authors.lastname: Yang
authors.affiliation: Microbiology Laboratory, Department of Bioindustry Technology, Dayeh University, Changhua 51591, Taiwan; Microbiology Laboratory, Department of Medicinal Botanicals and Healthcare, Da-Yeh University, Changhua 51591, Taiwan.
authors.forename: Taihao
authors.initials: T
authors.lastname: Hsu
authors.affiliation: Microbiology Laboratory, Department of Bioindustry Technology, Dayeh University, Changhua 51591, Taiwan.
authors.forename: Fangyi
authors.initials: F
authors.lastname: Lin
authors.affiliation: Natural Products Chemistry Research Laboratory, Department of Bioindustry Technology, Dayeh University, Changhua 51591, Taiwan.
authors.forename: Wenkuang
authors.initials: W
authors.lastname: Hsu
authors.affiliation: Natural Products Chemistry Research Laboratory, Department of Bioindustry Technology, Dayeh University, Changhua 51591, Taiwan.
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Chen
mesh_terms: D055453:Coriolaceae; D005285:Fermentation / Q000502:physiology*; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000378:metabolism*; D011124:Polyporaceae; D011134:Polysaccharides / Q000302:isolation & purification / Q000378:metabolism*; D055454:Trametes / Q000378:metabolism*
chemical_list: D007004:Hypoglycemic Agents; D011134:Polysaccharides