title: Double strand break (DSB) repair in heterochromatin and heterochromatin proteins in DSB repair.
abstract: Chromosomal translocations are a hallmark of cancer cells and they represent a major cause of tumorigenesis. To avoid chromosomal translocations, faithful repair of DNA double strand breaks (DSBs) has to be ensured in the context of high ordered chromatin structure. However, chromatin compaction is proposed to represent a barrier for DSB repair. Here we review the different mechanisms cells use to alleviate the heterochromatic barrier for DNA repair. At the same time, we discuss the activating role of heterochromatin-associated proteins in this process, therefore proposing that chromatin structure, more than being a simple barrier, is a key modulator of DNA repair.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), UMR 7104 CNRS, UdS, INSERM U964, BP 10142, F-67404 Illkirch Cedex, CU de Strasbourg, France.
authors.forename: Charlène
authors.initials: C
authors.lastname: Lemaître
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), UMR 7104 CNRS, UdS, INSERM U964, BP 10142, F-67404 Illkirch Cedex, CU de Strasbourg, France. Electronic address: evisou@igbmc.fr.
authors.forename: Evi
authors.initials: E
authors.lastname: Soutoglou
mesh_terms: D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics; D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D059766:DNA End-Joining Repair / Q000235:genetics; D004260:DNA Repair / Q000235:genetics*; D006570:Heterochromatin / Q000235:genetics*; D059765:Homologous Recombination / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D014178:Translocation, Genetic / Q000235:genetics; D000076183:Tripartite Motif-Containing Protein 28
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D006570:Heterochromatin; D012097:Repressor Proteins; D000090266:Chromobox Protein Homolog 5; C101116:TRIM28 protein, human; D000076183:Tripartite Motif-Containing Protein 28; D064007:Ataxia Telangiectasia Mutated Proteins
keywords: DDR; DNA repair; DSB; HP1; Heterochromatin; KAP1