title: Depression in Late-Life: a Focus on Prevention.
abstract: Depression is a leading cause of disease burden, disability and distress for millions of older adults. Thus, prevention of late-life depression is a priority research area. This article addresses the science of late-life depression prevention with the following: 1) an introduction to the Institute of Medicine framework of universal, selective and indicated prevention as it pertains to late-life depression, with particular attention to successes of indicated and selective prevention in primary care; 2) a discussion of how biomarkers can be integrated into prevention research, using interferon-alpha-induced depression as a model; 3) an outline for expansion of prevention to non-specialist care delivery systems in Low and Middle Income Countries - thus, extending the reach of current successful approaches; 4) a description of a novel approach to simultaneous testing of universal, selective and indicated prevention in late-life depression, with emphasis on study design features required to achieve practical, scalable tests of health impact.
authors.affiliation: Channing Division of Network Medicine (OIO), Department of Medicine, and Department of Psychiatry (OIO), Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Department of Psychiatry (JML), University of Rochester School of Medicine & Dentistry, Rochester, NY, United States; University of Pittsburgh Medical Center (FEL), Pittsburgh, PA, United States; Department of Psychiatry (CFR), University of Pittsburgh School of Medicine, and Department of Behavioral and Community Health Sciences (CFR), Graduate School of Public Health, Pittsburgh, PA, United States.
authors.forename: Olivia I
authors.initials: OI
authors.lastname: Okereke
authors.affiliation: Channing Division of Network Medicine (OIO), Department of Medicine, and Department of Psychiatry (OIO), Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Department of Psychiatry (JML), University of Rochester School of Medicine & Dentistry, Rochester, NY, United States; University of Pittsburgh Medical Center (FEL), Pittsburgh, PA, United States; Department of Psychiatry (CFR), University of Pittsburgh School of Medicine, and Department of Behavioral and Community Health Sciences (CFR), Graduate School of Public Health, Pittsburgh, PA, United States.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Lyness
authors.affiliation: Channing Division of Network Medicine (OIO), Department of Medicine, and Department of Psychiatry (OIO), Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Department of Psychiatry (JML), University of Rochester School of Medicine & Dentistry, Rochester, NY, United States; University of Pittsburgh Medical Center (FEL), Pittsburgh, PA, United States; Department of Psychiatry (CFR), University of Pittsburgh School of Medicine, and Department of Behavioral and Community Health Sciences (CFR), Graduate School of Public Health, Pittsburgh, PA, United States.
authors.forename: Francis E
authors.initials: FE
authors.lastname: Lotrich
authors.affiliation: Channing Division of Network Medicine (OIO), Department of Medicine, and Department of Psychiatry (OIO), Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Department of Psychiatry (JML), University of Rochester School of Medicine & Dentistry, Rochester, NY, United States; University of Pittsburgh Medical Center (FEL), Pittsburgh, PA, United States; Department of Psychiatry (CFR), University of Pittsburgh School of Medicine, and Department of Behavioral and Community Health Sciences (CFR), Graduate School of Public Health, Pittsburgh, PA, United States.
authors.forename: Charles F
authors.initials: CF
authors.lastname: Reynolds
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