title: Implications of cytokine genes in allergic asthma.
abstract: Asthma is a complex disease involving numerous mediator molecules and effector cells, in combination with a range of environmental determining factors. Cytokines play a key role in the physiopathological mechanisms of asthma; the study of the structure, regulation and variations of the genes that encode for these molecules is therefore crucial. Cytokines have extremely diverse roles, and exert effects both as activators and inhibitors of the innate and adaptive immune response. Certain modifications in the expression or structure of these molecules, resulting from the presence of polymorphisms, may give rise to deregulation of the mentioned effects, and therefore to a predisposition to develop concrete asthma phenotypes.
authors.affiliation: Department of Immunoallergy, Salamanca University Hospital, Salamanca, Spain; Biomedical Research Institute of Salamanca, IBSAL, Salamanca, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Padrón-Morales
authors.affiliation: Department of Immunoallergy, Salamanca University Hospital, Salamanca, Spain; Biomedical Research Institute of Salamanca, IBSAL, Salamanca, Spain.
authors.forename: V
authors.initials: V
authors.lastname: García-Solaesa
authors.affiliation: Biomedical Research Institute of Salamanca, IBSAL, Salamanca, Spain; Department of Clinical Biochemistry, Salamanca University Hospital, Salamanca, Spain; Department of Medicine, University of Salamanca, Salamanca, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Isidoro-García
authors.affiliation: Department of Immunoallergy, Salamanca University Hospital, Salamanca, Spain; Biomedical Research Institute of Salamanca, IBSAL, Salamanca, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Hernández-Hernández
authors.affiliation: Department of Immunoallergy, Salamanca University Hospital, Salamanca, Spain; Biomedical Research Institute of Salamanca, IBSAL, Salamanca, Spain.
authors.forename: A
authors.initials: A
authors.lastname: García-Sánchez
authors.affiliation: Biomedical Research Institute of Salamanca, IBSAL, Salamanca, Spain; Department of Clinical Biochemistry, Salamanca University Hospital, Salamanca, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Hincapié-López
authors.affiliation: Department of Immunoallergy, Salamanca University Hospital, Salamanca, Spain; Biomedical Research Institute of Salamanca, IBSAL, Salamanca, Spain; Department of Obstetrics, Ginecology and Pediatrics, University of Salamanca, Salamanca, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Lorente-Toledano
authors.affiliation: Department of Immunoallergy, Salamanca University Hospital, Salamanca, Spain; Biomedical Research Institute of Salamanca, IBSAL, Salamanca, Spain; Department of Obstetrics, Ginecology and Pediatrics, University of Salamanca, Salamanca, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Dávila
authors.affiliation: Biomedical Research Institute of Salamanca, IBSAL, Salamanca, Spain; Department of Microbiology and Genetics, University of Salamanca, Salamanca, Spain. Electronic address: catsof@usal.es.
authors.forename: C
authors.initials: C
authors.lastname: Sanz
mesh_terms: D000818:Animals; D001249:Asthma / Q000235:genetics* / Q000276:immunology*; D016207:Cytokines / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D016207:Cytokines