title: Interactions of cyclic and non-cyclic naphthalene diimide derivatives with different nucleic acids.
abstract: Recently, strategy based on stabilization of G-quadruplex telomeric DNA by small organic molecule has been realized by naphthalene diimide derivatives (NDIs). At the same time NDIs bind to DNA duplex as threading intercalators. Here we present cyclic derivative of naphthalene diimide (ligand 1) as DNA-binding ligand with ability to recognition of different structures of telomeric G-quadruplexes and ability to bis-intercalate to double-stranded helixes. The results have been compared to non-cyclic derivative (ligand 2) and revealed that preferential binding of ligands to nucleic acids strongly depends on their topology and structural features of ligands.
authors.affiliation: Research Center for Bio-microsensing Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi, Fukuoka 804-8550, Japan. Electronic address: izaczerw@amu.edu.pl.
authors.forename: Izabella
authors.initials: I
authors.lastname: Czerwinska
authors.affiliation: Research Center for Bio-microsensing Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi, Fukuoka 804-8550, Japan; Department of Applied Chemistry, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi, Fukuoka 804-8550, Japan.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Sato
authors.affiliation: Laboratory of Bioanalytical Chemistry, Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614 Poznań, Poland.
authors.forename: Bernard
authors.initials: B
authors.lastname: Juskowiak
authors.affiliation: Research Center for Bio-microsensing Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi, Fukuoka 804-8550, Japan; Department of Applied Chemistry, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi, Fukuoka 804-8550, Japan.
authors.forename: Shigeori
authors.initials: S
authors.lastname: Takenaka
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D054856:G-Quadruplexes; D007094:Imides / Q000737:chemistry* / Q000378:metabolism; D007364:Intercalating Agents / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D009281:Naphthalenes / Q000737:chemistry* / Q000378:metabolism; D009841:Oligonucleotides / Q000737:chemistry* / Q000378:metabolism; D019098:Telomerase / Q000378:metabolism; D044366:Transition Temperature
chemical_list: D007094:Imides; D007364:Intercalating Agents; D008024:Ligands; D009281:Naphthalenes; D009841:Oligonucleotides; C542131:naphthalenediimide; D004247:DNA; D019098:Telomerase
keywords: Double-stranded DNA; G-quadruplexes; Naphthalene diimide derivatives; Telomerase inhibition; Telomeric DNA