title: Transcriptional control of regulatory T-cell differentiation.
abstract: Regulatory T (Treg) cells are essential for maintaining peripheral tolerance and for limiting excessive inflammatory responses under various conditions. The lineage-specific transcription factor Foxp3 has a critical role in Treg-cell biology. Foxp3 forms large protein complexes and cooperates with environmentally induced transcription factors to shape the Treg-cell transcriptional program. Here, we discuss mechanisms of gene regulation that underlie Treg-cell differentiation and function with an emphasis on studies from our laboratory.
authors.affiliation: Howard Hughes Medical Institute, New York, New York 10065.
authors.forename: Joris
authors.initials: J
authors.lastname: van der Veeken
authors.affiliation: Howard Hughes Medical Institute, New York, New York 10065.
authors.forename: Aaron
authors.initials: A
authors.lastname: Arvey
authors.affiliation: Howard Hughes Medical Institute, New York, New York 10065 Immunology Program, New York, New York 10065 Ludwig Center at Memorial Sloan-Kettering Cancer Center, New York, New York 10065 rudenska@mskcc.org.
authors.forename: Alexander
authors.initials: A
authors.lastname: Rudensky
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D002462:Cell Membrane; D002843:Chromatin / Q000378:metabolism; D044127:Epigenesis, Genetic; D051858:Forkhead Transcription Factors / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D051379:Mice; D010641:Phenotype; D011401:Promoter Regions, Genetic; D050378:T-Lymphocytes, Regulatory / Q000166:cytology*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors