title: Trial design for breakthrough pain: is it ethical to have a placebo in a trial?
authors.affiliation: Cleveland Clinic Lerner School of Medicine, Case Western Reserve University, Cleveland, Ohio; Palliative Medicine and Supportive Oncology Services, Division of Solid Tumor, Taussig Cancer Institute, The Cleveland Clinic, Cleveland, Ohio.
authors.forename: Mellar P
authors.initials: MP
authors.lastname: Davis
authors.affiliation: Department of Palliative Care & Rehabilitation Medicine, F.T. McGraw Chair in the Treatment of Cancer, 1515 Holcombe Boulevard, Unit 1414, Houston, TX 77030.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bruera
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000627:therapeutic use*; D059390:Breakthrough Pain / Q000188:drug therapy*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000627:therapeutic use*; D006801:Humans; D008297:Male
chemical_list: D000701:Analgesics, Opioid; D005283:Fentanyl