title: Fatigue is associated with poor sleep in people with multiple sclerosis and cognitive impairment.
abstract: Background. Fatigue is the most common symptom in people with multiple sclerosis (MS). Poor sleep also occurs in this population. Objective. The objective of this study was to determine the relationship between fatigue and sleep quality in people with MS and cognitive impairment. Method. This cross-sectional study assessed relationships among fatigue, assessed with the Modified Fatigue Impact Scale (MFIS) and the Fatigue Severity Scale (FSS), sleep quality assessed with the Pittsburg Sleep Quality Index (PSQI), and demographics in 121 people with MS and cognitive impairment. Results. Fatigue was significantly correlated with poor sleep quality (MFIS: F = 15.60, P < 0.01; FSS: F = 12.09, P < 0.01). FSS scores were also significantly correlated with the PSQI subscore for daytime dysfunction and MFIS scores were significantly correlated with disability, age, and the PSQI subscores for sleep quality, sleep duration, and daytime dysfunction. Conclusions. This study demonstrates a relationship between fatigue and sleep quality in individuals with MS and cognitive impairment.
authors.affiliation: Department of Neurology, School of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road L226, Portland, OR 97239, USA ; Multiple Sclerosis Center of Excellence-West, Portland Department of Veterans Affairs Medical Center, Portland, OR 97239, USA.
authors.forename: Michelle H
authors.initials: MH
authors.lastname: Cameron
authors.affiliation: Portland Lung Clinic, Adventist Medical Center, Portland, OR 97216, USA.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Peterson
authors.affiliation: Department of Neurology, School of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road L226, Portland, OR 97239, USA ; Department of Medical Informatics and Clinical Epidemiology, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA ; Epilepsy Center of Excellence, Portland Veterans Affairs Medical Center, Portland, OR 97239, USA.
authors.forename: Eilis A
authors.initials: EA
authors.lastname: Boudreau
authors.affiliation: Department of Neurology, School of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road L226, Portland, OR 97239, USA ; Multiple Sclerosis Center of Excellence-West, Portland Department of Veterans Affairs Medical Center, Portland, OR 97239, USA.
authors.forename: Ashley
authors.initials: A
authors.lastname: Downs
authors.affiliation: Department of Neurology, School of Medicine, Louisiana State University Health Sciences Center-New Orleans, New Orleans, LA 70112, USA.
authors.forename: Jesus
authors.initials: J
authors.lastname: Lovera
authors.affiliation: Department of Neurology, School of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road L226, Portland, OR 97239, USA ; Multiple Sclerosis Center of Excellence-West, Portland Department of Veterans Affairs Medical Center, Portland, OR 97239, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: Kim
authors.affiliation: National Center for Rehabilitative Auditory Research, Portland Veterans Affairs Medical Center, Portland, OR 97239, USA.
authors.forename: Garnett P
authors.initials: GP
authors.lastname: McMillan
authors.affiliation: Department of Rehabilitation Medicine, University of Washington, VA Puget Sound Health Care System, VA MS Center of Excellence-West, Seattle, WA 98108, USA.
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Turner
authors.affiliation: Department of Rehabilitation Medicine, University of Washington, VA Puget Sound Health Care System, VA MS Center of Excellence-West, Seattle, WA 98108, USA ; Department of Epidemiology, University of Washington, VA Puget Sound Health Care System, VA MS Center of Excellence-West, Seattle, WA 98108, USA.
authors.forename: Jodie K
authors.initials: JK
authors.lastname: Haselkorn
authors.affiliation: Department of Neurology, School of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road L226, Portland, OR 97239, USA ; Multiple Sclerosis Center of Excellence-West, Portland Department of Veterans Affairs Medical Center, Portland, OR 97239, USA.
authors.forename: Dennis
authors.initials: D
authors.lastname: Bourdette
references.citation: Neurology. 1995 Nov;45(11):1956-61
references.pmid: 7501140
references.citation: Mult Scler. 2006 Feb;12(1):24-38
references.pmid: 16459717
references.citation: J Int Neuropsychol Soc. 2008 Sep;14(5):691-724
references.pmid: 18764967
references.citation: J Neurol Neurosurg Psychiatry. 2002 Feb;72(2):179-83
references.pmid: 11796766
references.citation: Neurology. 2012 Sep 18;79(12):1278-84
references.pmid: 22955125
references.citation: Arch Neurol. 1989 Oct;46(10):1121-3
references.pmid: 2803071
references.citation: Ann Indian Acad Neurol. 2008 Oct;11(4):236-41
references.pmid: 19893680
references.citation: Mult Scler. 2012 Feb;18(2):248-9
references.pmid: 21652611
references.citation: Neuropsychologia. 1999 Nov;37(12):1335-50
references.pmid: 10606009
references.citation: Arch Neurol. 2004 Apr;61(4):525-8
references.pmid: 15096400
references.citation: J Neurol. 2002 Aug;249(8):983-7
references.pmid: 12195441
references.citation: J Neurol Sci. 2011 Mar 15;302(1-2):7-13
references.pmid: 21241993
references.citation: Eur J Neurol. 2006 Dec;13(12):1333-9
references.pmid: 17116216
references.citation: Neurology. 2012 Aug 28;79(9):929-36
references.pmid: 22895593
references.citation: Chest. 2000 Aug;118(2):372-9
references.pmid: 10936127
references.citation: Psychiatry Res. 1989 May;28(2):193-213
references.pmid: 2748771
references.citation: Neurology. 2005 Apr 12;64(7):1139-43
references.pmid: 15824337
references.citation: Clin Infect Dis. 1994 Jan;18 Suppl 1:S79-83
references.pmid: 8148458
references.citation: J Pers Assess. 1996 Dec;67(3):588-97
references.pmid: 8991972
references.citation: Acta Neurol Scand. 2004 Jul;110(1):6-13
references.pmid: 15180801
references.citation: Mult Scler. 2010 Jun;16(6):724-32
references.pmid: 20375125
references.citation: J Sleep Res. 2005 Sep;14(3):245-53
references.pmid: 16120099
references.citation: Mult Scler. 1999 Apr;5(2):94-100
references.pmid: 10335517
references.citation: Mod Probl Pharmacopsychiatry. 1974;7(0):151-69
references.pmid: 4412100
references.citation: Acta Neurol Scand. 1995 Nov;92(5):353-5
references.pmid: 8610485
references.citation: J Clin Sleep Med. 2011 Oct 15;7(5 Suppl):S38-42
references.pmid: 22003330
references.citation: Mult Scler. 2012 Aug;18(8):1159-69
references.pmid: 22183937
references.citation: Mult Scler. 2002 Dec;8(6):523-6
references.pmid: 12474995
references.citation: Mult Scler. 2011 May;17(5):613-22
references.pmid: 21278050
references.citation: Mult Scler. 2013 Apr;19(4):480-9
references.pmid: 22914848