title: Riboswitches in regulation of Rho-dependent transcription termination.
abstract: Riboswitches are RNA sensors of small metabolites and ions that regulate gene expression in response to environmental changes. In bacteria, the riboswitch sensor domain usually controls the formation of a strong RNA hairpin that either functions as a potent transcription terminator or sequesters a ribosome-binding site. A recent study demonstrated a novel mechanism by which a riboswitch controls Rho-dependent transcription termination. This riboswitch mechanism is likely a widespread mode of gene regulation that determines whether a protein effector is able to attenuate transcription. This article is part of a Special Issue entitled: Riboswitches.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow 119991, Russia; State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow 117545, Russia.
authors.forename: Sergey
authors.initials: S
authors.lastname: Proshkin
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow 119991, Russia; State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow 117545, Russia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Mironov
authors.affiliation: Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University Langone Medical Center, New York, NY 10016, USA. Electronic address: evgeny.nudler@nyumc.org.
authors.forename: Evgeny
authors.initials: E
authors.lastname: Nudler
keywords: Rho; Riboswitch; Transcription termination