title: Radiation synthesis and characterization of hyaluronan capped gold nanoparticles.
abstract: Gold nanoparticles (AuNPs) with diameter from 4 to 10nm, capping by hyaluronan (HA) were synthesized using a γ-irradiation method. The maximum absorption wavelengths at 517-525 nm of colloidal AuNPs/HA solutions were measured by UV-vis spectroscopy. The size and size distribution of AuNPs were determined from TEM images. The influence of various factors on the size of AuNPs particularly the concentration of Au3+ and HA, and dose rate were also investigated. Results indicated that higher dose rate and HA concentration favor smaller sizes of AuNPs whereas the size increases with Au3+ concentration. The colloidal AuNPs/HA solution was fairly stable more than 6 months under storage at ambient condition. The AuNPs stabilized by biocompatible HA with the size less than 10nm as prepared can potentially be applied in biomedicines and cosmetics.
authors.affiliation: Research and Development Center for Radiation Technology, Vietnam Atomic Energy Institute, 202A, Street 11, Linh Xuan Ward, Thu Duc District, Ho Chi Minh City, Viet Nam.
authors.forename: Nguyen Quoc
authors.initials: NQ
authors.lastname: Hien
authors.forename: Dang
authors.initials: D
authors.lastname: Van Phu
authors.forename: Nguyen Ngoc
authors.initials: NN
authors.lastname: Duy
authors.forename: Le Anh
authors.initials: le A
authors.lastname: Quoc
mesh_terms: D005720:Gamma Rays; D006046:Gold / Q000737:chemistry / Q000528:radiation effects*; D006820:Hyaluronic Acid / Q000737:chemistry / Q000528:radiation effects*; D053768:Metal Nanoparticles / Q000737:chemistry / Q000528:radiation effects*
chemical_list: D006046:Gold; D006820:Hyaluronic Acid