title: Joint failure after steroid therapy in tuberculous encephalitis.
abstract: We report a case of multifocal avascular osteonecrosis (AVN) following steroid administration in a case of tuberculous encephalitis in a young patient. The risk of joint-related AVN as a side effect of adjunctive steroid therapy should be taken into consideration when evaluating the dosage and treatment duration in tuberculous encephalitis.
authors.affiliation: From the 1 Department of Orthopaedic Surgery, Medical Faculty, Heinrich-Heine University of Düsseldorf , Düsseldorf.
authors.forename: Christoph
authors.initials: C
authors.lastname: Ziskoven
authors.forename: Joachim
authors.initials: J
authors.lastname: Richter
authors.forename: Thilo
authors.initials: T
authors.lastname: Patzer
authors.forename: Jörn
authors.initials: J
authors.lastname: Kircher
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Krauspe
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D004660:Encephalitis / Q000188:drug therapy*; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D058430:Humeral Head / Q000000981:diagnostic imaging / Q000601:surgery; D007538:Isoniazid / Q000627:therapeutic use; D007592:Joint Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging; D011239:Prednisolone / Q000009:adverse effects* / Q000627:therapeutic use; D011859:Radiography; D012293:Rifampin / Q000627:therapeutic use; D020306:Tuberculosis, Central Nervous System / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D000995:Antitubercular Agents; D011239:Prednisolone; D007538:Isoniazid; D012293:Rifampin
keywords: Tuberculosis; avascular necrosis; steroid therapy