title: The expression analysis of LATS2 gene in de novo AML patients.
abstract: Acute myeloid leukemia is a heterogeneous disease with respect to presentation and clinical outcome. Acquired genetic alterations along with epigenetic changes in hematopoietic progenitor cells are associated with the disease development. LATS2, as a tumor suppressor, has been indicated to have expression variations in different cancers. The aim of the present study was to analyze the expression level of the LATS2 gene in acute myeloid leukemia (AML) patients. Using quantitative real-time PCR, the expression level of the LATS2 gene was detected in peripheral blood samples from 32 patients with de novo AML and 10 normal controls. LATS2 gene was significantly over-expressed in AML patients compared to normal subjects. Significant LATS2 over-expression was observed in all FAB types except for the M3 (p = 0.661). The present work provides the first evidence of the over-expression of LATS2 in AML patients and suggests that the gene might play a role in the disease development and hence may be a potential therapeutic target for AML treatment.
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Koodakyar St.,Velenjak St., Shahid Chamran Highway, 19395-4719, Tehran, Iran.
authors.forename: Milad
authors.initials: M
authors.lastname: Gholami
authors.forename: Reza
authors.initials: R
authors.lastname: Mirfakhraie
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Movafagh
authors.forename: Hasan
authors.initials: H
authors.lastname: Jalaeekhoo
authors.forename: Ramezanali
authors.initials: R
authors.lastname: Kalahroodi
authors.forename: Davood
authors.initials: D
authors.lastname: Zare-Abdollahi
authors.forename: Shohreh
authors.initials: S
authors.lastname: Zare-Karizi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015996:Survival Rate; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D025521:Tumor Suppressor Proteins; C406449:LATS2 protein, human; D017346:Protein Serine-Threonine Kinases
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