title: Rab'ing tumor cell migration and invasion: focal adhesion disassembly driven by Rab5.
abstract: The small GTPase Rab5 has been extensively studied in the context of endocytic trafficking because it is critical in the regulation of early endosome dynamics. In addition to this canonical role, evidence obtained in recent years implicates Rab5 in the regulation of cell migration. This novel role of Rab5 is based not only on an indirect relationship between cell migration and endosomal trafficking as separate processes, but also on the direct regulation of signaling proteins implicated in cell migration. However, the precise mechanisms underlying this connection have remained elusive. Recent studies have shown that the activation of Rab5 is a critical event for maintaining the dynamics of focal adhesions, which is fundamental in regulating not only cell migration but also tumor cell invasion.
authors.affiliation: Institute for Research in Dental Sciences; Faculty of Dentistry; Universidad de Chile; Santiago, Chile.
authors.forename: Vicente A
authors.initials: VA
authors.lastname: Torres
mesh_terms: D002465:Cell Movement / Q000235:genetics*; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D022001:Focal Adhesions / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D034741:RNA, Small Interfering / Q000235:genetics; D015398:Signal Transduction; D020696:rab5 GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D034741:RNA, Small Interfering; D051416:Focal Adhesion Protein-Tyrosine Kinases; C427755:RAB5C protein, human; D020696:rab5 GTP-Binding Proteins
keywords: Rab5; cell migration; focal adhesion; invasion
references.citation: Nature. 2004 May 20;429(6989):309-14
references.pmid: 15152255
references.citation: Curr Biol. 2001 Sep 18;11(18):1392-402
references.pmid: 11566097
references.citation: Mol Biol Cell. 2005 Dec;16(12):5793-803
references.pmid: 16207819
references.citation: J Biol Chem. 2008 Dec 26;283(52):36280-9
references.pmid: 18974049
references.citation: Cell Cycle. 2006 Oct;5(19):2179-82
references.pmid: 16969102
references.citation: Mol Biol Cell. 2011 May;22(9):1529-38
references.pmid: 21411625
references.citation: Curr Protein Pept Sci. 2011 Feb;12(1):43-51
references.pmid: 21190523
references.citation: Mol Biol Cell. 2010 Jan 15;21(2):369-76
references.pmid: 19923319
references.citation: Cell Res. 2012 Oct;22(10):1479-501
references.pmid: 22825554
references.citation: J Mol Med (Berl). 2013 Jul;91(7):803-9
references.pmid: 23609221
references.citation: J Cell Biol. 1998 Jul 13;142(1):181-90
references.pmid: 9660872
references.citation: FEBS Lett. 2009 Apr 17;583(8):1337-43
references.pmid: 19306879
references.citation: Curr Opin Cell Biol. 2012 Oct;24(5):569-81
references.pmid: 22819514
references.citation: J Cell Sci. 2005 Oct 1;118(Pt 19):4415-25
references.pmid: 16159962
references.citation: Nat Cell Biol. 2005 Jun;7(6):581-90
references.pmid: 15895076
references.citation: Nat Rev Mol Cell Biol. 2005 Jan;6(1):56-68
references.pmid: 15688067
references.citation: Curr Biol. 2013 Dec 2;23(23):2355-64
references.pmid: 24239119
references.citation: J Biol Chem. 2007 Jun 1;282(22):16599-611
references.pmid: 17409386
references.citation: Mol Cell Biol. 2010 Feb;30(3):781-92
references.pmid: 19995918
references.citation: Nat Cell Biol. 2002 Apr;4(4):E97-100
references.pmid: 11944043
references.citation: Science. 2003 Dec 5;302(5651):1704-9
references.pmid: 14657486
references.citation: Cell. 2008 Jul 11;134(1):135-47
references.pmid: 18614017
references.citation: J Cell Sci. 2013 Sep 1;126(Pt 17):3835-47
references.pmid: 23813952
references.citation: Curr Opin Cell Biol. 2008 Feb;20(1):85-90
references.pmid: 18083360
references.citation: Nat Rev Mol Cell Biol. 2009 Aug;10(8):513-25
references.pmid: 19603039
references.citation: Mol Biol Cell. 1999 Oct;10(10):3239-50
references.pmid: 10512863
references.citation: J Cell Biol. 2012 Feb 6;196(3):375-85
references.pmid: 22291036
references.citation: Annu Rev Cell Dev Biol. 2011;27:185-211
references.pmid: 21801014
references.citation: J Cell Biol. 2006 Jun 5;173(5):767-80
references.pmid: 16754960
references.citation: J Cell Biol. 2009 Nov 30;187(5):733-47
references.pmid: 19951918
references.citation: Curr Opin Cell Biol. 2012 Feb;24(1):116-24
references.pmid: 22138388