title: Arachis hypogaeaL. stem and leaf extract improves the sleep behavior of pentobarbital-treated rats.
abstract: This study was conducted to evaluate the sedative effects ofArachis hypogaeaL. stem and leaf extract (AHSLE) and determine its effect pathways through γ-aminobutyric acid (GABA)-gated channels on male Sprague-Dawley rats treated with pentobarbital. AHSLE was obtained from 98°C water (3 h, extracted twice). AHSLE and flumazenil (a GABA type A receptor antagonist) were administered to the rats orally, whereas pentobarbital sodium and muscimol (a GABA type A receptor agonist) were administered intraperitoneally (i.p.). The results demonstrated that AHSLE decreased sleep latency and increased sleep time in pentobarbital-treated rats (50 mg/kg, i.p.). The coadministration of AHSLE and muscimol (0.05 mg/kg) significantly increased sleep time and reduced sleep latency in pentobarbital-treated rats and these actions were significantly antagonized by flumazenil at a dose of 3.5 mg/kg. These results indicated that AHSLE improved the sleep behavior in pentobarbital-treated rats, possibly through GABA-gated channel-related mechanisms.
authors.affiliation: Institute for Farm Products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan, Hubei 430064, P.R. China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zu
authors.affiliation: Institute for Farm Products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan, Hubei 430064, P.R. China.
authors.forename: Guang-Quan
authors.initials: GQ
authors.lastname: Xiong
authors.affiliation: Institute for Farm Products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan, Hubei 430064, P.R. China.
authors.forename: Sheng-Rong
authors.initials: SR
authors.lastname: Geng
authors.affiliation: Institute for Farm Products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan, Hubei 430064, P.R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liao
authors.affiliation: Institute for Farm Products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan, Hubei 430064, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
authors.forename: Zhen-Ya
authors.initials: ZY
authors.lastname: Zhang
keywords: Arachis hypogaea L. stem and leaf extract; pentobarbital-treated rats; sleep behaviors
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