title: Beta cell imaging - a key tool in optimized diabetes prevention and treatment.
abstract: The prevalence of diabetes is 382 million worldwide, and is expected to rise to 592 million in 2035 (http://www.idf.org/diabetesatlas); 2.5-15% of national annual healthcare budgets are related to diabetes care, potentially increasing to 40% in high-prevalence countries. Beta cell dysfunction and death are central events in diabetes pathogenesis, but the natural history of beta cell loss remains unknown. Clinical imaging of beta cells will play a pivotal role in developing strategies for optimized diabetes prevention and treatment.
authors.affiliation: Radboud University Medical Center, Department of Radiology and Nuclear Medicine, PO Box 9101, 6500HB Nijmegen, The Netherlands. Electronic address: martin.gotthardt@radboudumc.nl.
authors.forename: Martin
authors.initials: M
authors.lastname: Gotthardt
authors.affiliation: Laboratory of Experimental Medicine and ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), CP 618, 1070 Brussels, Belgium.
authors.forename: Decio L
authors.initials: DL
authors.lastname: Eizirik
authors.affiliation: Laboratory of Experimental Medicine and ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), CP 618, 1070 Brussels, Belgium; Division of Endocrinology, Erasmus Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium.
authors.forename: Miriam
authors.initials: M
authors.lastname: Cnop
authors.affiliation: Radboud University Medical Center, Department of Radiology and Nuclear Medicine, PO Box 9101, 6500HB Nijmegen, The Netherlands.
authors.forename: Maarten
authors.initials: M
authors.lastname: Brom
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000517:prevention & control* / Q000628:therapy*; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000378:metabolism*
chemical_list: D007328:Insulin
keywords: diabetes; imaging; pancreatic beta cells; pancreatic islets