title: Enhancement mechanisms of graphene in nano-58S bioactive glass scaffold: mechanical and biological performance.
abstract: Graphene is a novel material and currently popular as an enabler for the next-generation nanocomposites. Here, we report the use of graphene to improve the mechanical properties of nano-58S bioactive glass for bone repair and regeneration. And the composite scaffolds were fabricated by a homemade selective laser sintering system. Qualitative and quantitative analysis demonstrated the successful incorporation of graphene into the scaffold without obvious structural damage and weight loss. The optimum compressive strength and fracture toughness reached 48.65 ± 3.19 MPa and 1.94 ± 0.10 MPa · m(1/2) with graphene content of 0.5 wt%, indicating significant improvements by 105% and 38% respectively. The mechanisms of pull-out, crack bridging, crack deflection and crack tip shielding were found to be responsible for the mechanical enhancement. Simulated body fluid and cell culture tests indicated favorable bioactivity and biocompatibility of the composite scaffold. The results suggest a great potential of graphene/nano-58S composite scaffold for bone tissue engineering applications.
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, P. R. China.
authors.forename: Chengde
authors.initials: C
authors.lastname: Gao
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, P. R. China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Liu
authors.affiliation: 1] State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, P. R. China [2] Department of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Cijun
authors.initials: C
authors.lastname: Shuai
authors.affiliation: 1] Cancer Research Institute, Central South University, Changsha 410078, P. R. China [2] Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Shuping
authors.initials: S
authors.lastname: Peng
mesh_terms: D045744:Cell Line, Tumor; D019245:Compressive Strength; D005898:Glass / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013818:Thermogravimetry; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: C448994:bioactive glass 58S; D006108:Graphite
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