title: Ability of different rescue therapies to save the bowel in acute, severe, steroid-refractory ulcerative colitis.
abstract: To date, corticosteroids have been the primary therapies for acute, severe ulcerative colitis (UC). Patients not responding to intravenous steroids assessed at 3-5 days of the treatment are candidates for second-line rescue therapy. Cyclosporine (CsA), tacrolimus and infliximab (IFX) are also effective therapeutic options in acute, severe UC. In this review we summarized the results of the published studies examining and comparing the efficacy of CsA, tacrolimus and IFX as rescue therapies, and assessing the outcome of switching the drugs in case of therapeutic failure.
authors.affiliation: First Department of Medicine, University of Szeged, 8-10 Koranyi fasor, Szeged, H6720, Hungary.
authors.forename: Klaudia
authors.initials: K
authors.lastname: Farkas
authors.forename: Tamás
authors.initials: T
authors.lastname: Molnár
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szepes
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000188:drug therapy*; D016572:Cyclosporine / Q000627:therapeutic use; D004351:Drug Resistance; D057915:Drug Substitution; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000069285:Infliximab; D016879:Salvage Therapy / Q000009:adverse effects / Q000379:methods*; D012720:Severity of Illness Index; D016559:Tacrolimus / Q000627:therapeutic use; D017211:Treatment Failure
chemical_list: D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D000069285:Infliximab; D016559:Tacrolimus
keywords: acute ulcerative colitis; cyclosporine; infliximab; rescue therapy; tacrolimus