title: Intercellular protein-protein interactions at synapses.
abstract: Chemical synapses are asymmetric intercellular junctions through which neurons send nerve impulses to communicate with other neurons or excitable cells. The appropriate formation of synapses, both spatially and temporally, is essential for brain function and depends on the intercellular protein-protein interactions of cell adhesion molecules (CAMs) at synaptic clefts. The CAM proteins link pre- and post-synaptic sites, and play essential roles in promoting synapse formation and maturation, maintaining synapse number and type, accumulating neurotransmitter receptors and ion channels, controlling neuronal differentiation, and even regulating synaptic plasticity directly. Alteration of the interactions of CAMs leads to structural and functional impairments, which results in many neurological disorders, such as autism, Alzheimer's disease and schizophrenia. Therefore, it is crucial to understand the functions of CAMs during development and in the mature neural system, as well as in the pathogenesis of some neurological disorders. Here, we review the function of the major classes of CAMs, and how dysfunction of CAMs relates to several neurological disorders.
authors.affiliation: Key Laboratory of Cognitive Science, Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering, South-Central University for Nationalities, Wuhan, 430074, China, sunlittlefly@gmail.com.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Yang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Hou
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009422:Nervous System Diseases / Q000378:metabolism / Q000473:pathology; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism; D060066:Protein Interaction Maps; D013569:Synapses / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules
references.citation: Neuron. 2005 Jun 16;46(6):917-31
references.pmid: 15953420
references.citation: Nature. 1983 Sep 29-Oct 5;305(5933):427-30
references.pmid: 6621692
references.citation: J Med Genet. 2011 Jan;48(1):48-54
references.pmid: 20972252
references.citation: Curr Biol. 2002 Feb 5;12(3):181-90
references.pmid: 11839269
references.citation: Hum Mol Genet. 2008 Feb 1;17(3):458-65
references.pmid: 17989066
references.citation: J Neurochem. 2012 Jul;122(1):147-61
references.pmid: 22519304
references.citation: Cell Adhes Commun. 1998;6(5):415-30
references.pmid: 10223357
references.citation: J Neurosci. 2007 Nov 14;27(46):12516-30
references.pmid: 18003830
references.citation: Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11116-21
references.pmid: 20534458
references.citation: Science. 2002 Aug 30;297(5586):1525-31
references.pmid: 12202822
references.citation: Behav Brain Res. 2013 Feb 1;238:69-78
references.pmid: 23089646
references.citation: Neurosci Lett. 2010 Apr 5;473(2):102-6
references.pmid: 20176085
references.citation: Mol Cell Neurosci. 2008 Sep;39(1):83-94
references.pmid: 18585462
references.citation: Neurogenetics. 2011 Nov;12(4):315-23
references.pmid: 21837366
references.citation: Neuron. 2002 Mar 28;34(1):39-52
references.pmid: 11931740
references.citation: Proc Natl Acad Sci U S A. 1995 May 9;92(10):4323-7
references.pmid: 7753806
references.citation: Nat Rev Neurosci. 2007 Mar;8(3):206-20
references.pmid: 17299456
references.citation: J Neurosci. 2009 Sep 2;29(35):10843-54
references.pmid: 19726642
references.citation: Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11686-90
references.pmid: 8524829
references.citation: Cell. 2004 Oct 15;119(2):257-72
references.pmid: 15479642
references.citation: Neuron. 2010 Oct 6;68(1):9-18
references.pmid: 20920787
references.citation: J Neurochem. 1996 Apr;66(4):1532-8
references.pmid: 8627309
references.citation: Brain Res Mol Brain Res. 1998 Apr;55(2):265-76
references.pmid: 9582434
references.citation: J Neurosci. 2006 Jun 28;26(26):6968-78
references.pmid: 16807326
references.citation: Neurosci Lett. 2006 Nov 27;409(1):10-3
references.pmid: 17034946
references.citation: J Biol Chem. 2008 Mar 28;283(13):8395-405
references.pmid: 18227064
references.citation: J Neurochem. 2011 Oct;119(2):354-63
references.pmid: 21699541
references.citation: Am J Hum Genet. 2004 Mar;74(3):552-7
references.pmid: 14963808
references.citation: Brain Struct Funct. 2015 Jan;220(1):47-58
references.pmid: 25713840
references.citation: J Comp Neurol. 1996 Nov 11;375(2):289-302
references.pmid: 8915831
references.citation: Cell Mol Life Sci. 2006 Aug;63(16):1833-49
references.pmid: 16794786
references.citation: Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7265-70
references.pmid: 17440041
references.citation: Neuron. 1995 Mar;14(3):497-507
references.pmid: 7695896
references.citation: Cell Biochem Funct. 2009 Oct;27(7):496-8
references.pmid: 19711485
references.citation: PLoS Biol. 2008 Apr 29;6(4):e103
references.pmid: 18447583
references.citation: Neuron. 2009 Dec 24;64(6):799-806
references.pmid: 20064388
references.citation: J Neurol Sci. 2005 Feb 15;228(2):129-35
references.pmid: 15694193
references.citation: Behav Brain Funct. 2005 Aug 31;1:15
references.pmid: 16131404
references.citation: EMBO J. 1999 Sep 1;18(17):4744-53
references.pmid: 10469653
references.citation: Neuron. 2011 Jun 9;70(5):863-85
references.pmid: 21658581
references.citation: Nat Neurosci. 2006 Oct;9(10):1294-301
references.pmid: 16980967
references.citation: Neuron. 2009 Dec 24;64(6):791-8
references.pmid: 20064387
references.citation: J Neurosci. 2007 Jul 11;27(28):7508-19
references.pmid: 17626212
references.citation: Annu Rev Cell Dev Biol. 2009;25:161-95
references.pmid: 19575668
references.citation: Neuron. 2013 Aug 21;79(4):680-95
references.pmid: 23911104
references.citation: EMBO J. 1996 Nov 15;15(22):6050-9
references.pmid: 8947027
references.citation: PLoS One. 2011 Apr 29;6(4):e19430
references.pmid: 21559374
references.citation: J Cell Sci. 2012 Aug 15;125(Pt 16):3713-22
references.pmid: 23027581
references.citation: Development. 1988 Apr;102(4):639-55
references.pmid: 3048970
references.citation: J Biol Chem. 2011 Jan 7;286(1):851-8
references.pmid: 21056983
references.citation: Schweiz Arch Neurol Neurochir Psychiatr. 1972;111(2):227-36
references.pmid: 4653249
references.citation: J Neurochem. 2011 Dec;119(5):945-56
references.pmid: 21910732
references.citation: Cell Mol Biol Lett. 2009;14(1):57-69
references.pmid: 18839070
references.citation: Neuron. 2006 Jul 20;51(2):171-8
references.pmid: 16846852
references.citation: Cell. 2008 Apr 18;133(2):328-39
references.pmid: 18423203
references.citation: Mol Cell Proteomics. 2008 Apr;7(4):684-96
references.pmid: 18056256
references.citation: Brain Res. 2008 Aug 11;1224:1-11
references.pmid: 18602091
references.citation: Neuron. 2003 Jan 23;37(2):263-74
references.pmid: 12546821
references.citation: Cell. 2013 Jul 3;154(1):75-88
references.pmid: 23827676
references.citation: Nat Neurosci. 2007 Jan;10(1):67-76
references.pmid: 17143272
references.citation: J Cell Biol. 1972 Dec;55(3):696-711
references.pmid: 4656707
references.citation: Eur J Neurosci. 2006 Apr;23(7):1839-52
references.pmid: 16623841
references.citation: Mol Cell Neurosci. 2006 Feb;31(2):315-25
references.pmid: 16300961
references.citation: Neuron. 2007 Jun 21;54(6):919-31
references.pmid: 17582332
references.citation: Schizophr Bull. 1987;13(4):577-87
references.pmid: 3438707
references.citation: J Biol Chem. 2007 Jun 1;282(22):16155-63
references.pmid: 17428795
references.citation: Nat Rev Neurosci. 2007 Jan;8(1):11-20
references.pmid: 17133224
references.citation: J Cell Biol. 2003 Dec 22;163(6):1313-26
references.pmid: 14691139
references.citation: Neuron. 2008 Jun 12;58(5):749-62
references.pmid: 18549786
references.citation: Nature. 1988 Aug 25;334(6184):701-3
references.pmid: 3412448
references.citation: J Cell Biol. 2007 Sep 24;178(7):1295-307
references.pmid: 17875741
references.citation: Genome Biol. 2013;14(9):213
references.pmid: 24083347
references.citation: J Neurophysiol. 2005 Aug;94(2):1037-47
references.pmid: 15800072
references.citation: Biochem Biophys Res Commun. 2009 Aug 7;385(4):539-44
references.pmid: 19481057
references.citation: Neuron. 2007 May 3;54(3):461-77
references.pmid: 17481398
references.citation: J Neurogenet. 2010 Dec;24(4):182-93
references.pmid: 20615089
references.citation: Mol Cell Proteomics. 2006 Jun;5(6):1158-70
references.pmid: 16507876
references.citation: J Neurochem. 1998 Oct;71(4):1339-47
references.pmid: 9751164
references.citation: J Cell Biol. 2009 May 4;185(3):551-64
references.pmid: 19414612
references.citation: Brain Pathol. 2012 Nov;22(6):776-87
references.pmid: 22404518
references.citation: Neuron. 2001 Dec 6;32(5):815-28
references.pmid: 11738028
references.citation: Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16502-9
references.pmid: 21953696
references.citation: J Neurosci. 2004 May 19;24(20):4889-93
references.pmid: 15152050
references.citation: Behav Brain Res. 2004 Sep 23;154(1):171-82
references.pmid: 15302123
references.citation: Mol Cell Neurosci. 2004 May;26(1):191-203
references.pmid: 15121190
references.citation: J Neurosci. 2007 Dec 19;27(51):14205-15
references.pmid: 18094260
references.citation: Physiol Rev. 2012 Apr;92(2):597-634
references.pmid: 22535893
references.citation: Nat Neurosci. 2004 Jan;7(1):33-40
references.pmid: 14699416
references.citation: Alzheimers Dement. 2007 Jul;3(3):186-91
references.pmid: 19595937
references.citation: J Biol Chem. 1999 Dec 31;274(53):37965-73
references.pmid: 10608864
references.citation: Am J Hum Genet. 2004 Jun;74(6):1286-93
references.pmid: 15106122
references.citation: J Biol Chem. 2005 Apr 29;280(17):17312-9
references.pmid: 15723836
references.citation: Science. 2002 Jun 7;296(5574):1864-9
references.pmid: 12052960
references.citation: Biol Psychiatry. 1988 Apr 15;23(8):769-75
references.pmid: 3365455
references.citation: Mol Psychiatry. 2008 Jun;13(6):558-69
references.pmid: 18317468
references.citation: Neuron. 2001 Dec 20;32(6):1041-56
references.pmid: 11754836
references.citation: Science. 1966 Dec 23;154(3756):1575-7
references.pmid: 5924927
references.citation: J Alzheimers Dis. 2009;17(4):773-86
references.pmid: 19542617
references.citation: Neuron. 2001 Jun;30(3):707-23
references.pmid: 11430805
references.citation: PLoS One. 2010 Oct 18;5(10):e13462
references.pmid: 20976158
references.citation: J Cell Sci. 2013 Jan 1;126(Pt 1):77-89
references.pmid: 23015592
references.citation: Mol Cell Neurosci. 2003 Dec;24(4):1000-11
references.pmid: 14697664
references.citation: Nat Neurosci. 2009 Jan;12(1):15-20
references.pmid: 19029886
references.citation: Brain Res Mol Brain Res. 2000 Oct 20;82(1-2):84-94
references.pmid: 11042360
references.citation: J Neurosci. 2000 Sep 1;20(17):6529-39
references.pmid: 10964958
references.citation: Cell. 1998 Sep 18;94(6):773-82
references.pmid: 9753324
references.citation: J Neurochem. 1998 May;70(5):1839-49
references.pmid: 9572267
references.citation: J Ultrastruct Res. 1971 Jun;35(5):451-75
references.pmid: 4111038
references.citation: Nature. 2011 Jan 6;469(7328):47-52
references.pmid: 21113149
references.citation: Nat Neurosci. 2011 Jan;14(1):19-21
references.pmid: 21170055
references.citation: Neuroscience. 2003;117(3):645-58
references.pmid: 12617969
references.citation: Eur J Cell Biol. 2004 Sep;83(9):449-56
references.pmid: 15540461
references.citation: Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13290-5
references.pmid: 9789081
references.citation: Eur J Hum Genet. 2010 Apr;18(4):429-35
references.pmid: 19920853
references.citation: Mol Cell Neurosci. 2010 Dec;45(4):378-88
references.pmid: 20678574
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1710-5
references.pmid: 18227507
references.citation: Science. 1995 Sep 15;269(5230):1578-80
references.pmid: 7667637
references.citation: Nat Neurosci. 2009 Oct;12(10):1285-92
references.pmid: 19734893
references.citation: Curr Opin Neurobiol. 2007 Feb;17(1):43-52
references.pmid: 17275284
references.citation: Mol Cell Neurosci. 2012 May;50(1):35-44
references.pmid: 22449939
references.citation: Eur J Neurosci. 2011 Mar;33(5):768-818
references.pmid: 21385235
references.citation: J Neurosci. 1999 Feb 15;19(4):1307-16
references.pmid: 9952408
references.citation: Neurosci Lett. 2008 Jul 18;439(3):235-40
references.pmid: 18534753
references.citation: Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6137-42
references.pmid: 15837930
references.citation: Cell Signal. 2012 Mar;24(3):606-11
references.pmid: 22120527
references.citation: J Neurosci. 2013 Apr 3;33(14):5957-68
references.pmid: 23554477
references.citation: J Cell Biol. 2011 Jul 25;194(2):323-34
references.pmid: 21788371
references.citation: J Biol Chem. 2009 Oct 2;284(40):27220-8
references.pmid: 19661068
references.citation: Semin Cell Dev Biol. 2012 Feb;23(1):65-74
references.pmid: 22040914
references.citation: Hippocampus. 2013 Dec;23(12):1367-82
references.pmid: 23939883
references.citation: J Cell Biol. 2002 Feb 4;156(3):555-65
references.pmid: 11827984
references.citation: Nat Neurosci. 2006 Feb;9(2):234-42
references.pmid: 16415866
references.citation: J Neurochem. 2007 Dec;103(5):1855-63
references.pmid: 17868325
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12539-44
references.pmid: 18723684
references.citation: Nature. 1959 Jun 6;183(4675):1592-3
references.pmid: 13666826
references.citation: Neuron. 2003 Nov 13;40(4):719-31
references.pmid: 14622577
references.citation: Exp Neurol. 1998 Feb;149(2):424-32
references.pmid: 9500955
references.citation: Gene. 2012 Sep 1;505(2):201-5
references.pmid: 22750301
references.citation: Nat Struct Mol Biol. 2008 Jan;15(1):50-6
references.pmid: 18084303
references.citation: Nat Rev Mol Cell Biol. 2002 Jul;3(7):475-86
references.pmid: 12094214
references.citation: Mol Cell Biol. 1991 Mar;11(3):1654-61
references.pmid: 1996115
references.citation: Cell. 2005 Feb 11;120(3):421-33
references.pmid: 15707899
references.citation: Autism Res. 2011 Jun;4(3):189-99
references.pmid: 21308999
references.citation: Dev Neurobiol. 2009 Oct;69(12):811-24
references.pmid: 19672956
references.citation: J Neurosci. 2013 Mar 27;33(13):5584-9
references.pmid: 23536073
references.citation: Neuron. 2013 Aug 7;79(3):439-46
references.pmid: 23931994
references.citation: J Cell Biol. 2006 Sep 25;174(7):1071-85
references.pmid: 17000882
references.citation: Genomics. 2002 Jun;79(6):849-59
references.pmid: 12036300
references.citation: J Cell Biol. 1987 Feb;104(2):355-62
references.pmid: 3543026
references.citation: Neurosci Lett. 2008 Jun 27;438(3):368-70
references.pmid: 18490107
references.citation: Science. 2007 Oct 5;318(5847):71-6
references.pmid: 17823315
references.citation: Nat Genet. 2009 Feb;41(2):192-8
references.pmid: 19136949
references.citation: J Biol Chem. 1997 Oct 10;272(41):26032-9
references.pmid: 9325340
references.citation: Cereb Cortex. 2010 Nov;20(11):2684-93
references.pmid: 20156840
references.citation: Eur J Neurosci. 2010 Jul;32(2):198-206
references.pmid: 20646051
references.citation: Biochemistry. 2006 Oct 24;45(42):12816-27
references.pmid: 17042500
references.citation: J Comp Neurol. 2012 Jun 15;520(9):2041-52
references.pmid: 22488504
references.citation: J Neurosci. 2010 Apr 21;30(16):5559-68
references.pmid: 20410109
references.citation: J Neurosci. 2003 Nov 12;23(32):10419-32
references.pmid: 14614101
references.citation: Nat Neurosci. 2007 Sep;10(9):1151-9
references.pmid: 17721516
references.citation: Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1323-8
references.pmid: 22232691
references.citation: Brain Res. 2007 Aug 24;1165:5-14
references.pmid: 17658490
references.citation: Neuron. 1996 Sep;17(3):413-22
references.pmid: 8816705
references.citation: Curr Opin Neurobiol. 2011 Apr;21(2):208-14
references.pmid: 21255999
references.citation: Mol Syst Biol. 2009;5:269
references.pmid: 19455133
references.citation: Neuron. 2006 Sep 21;51(6):741-54
references.pmid: 16982420
references.citation: Mol Brain. 2009 Jun 17;2:18
references.pmid: 19534762
references.citation: PLoS One. 2009;4(4):e5251
references.pmid: 19370153
references.citation: Neuron. 2010 Dec 9;68(5):894-906
references.pmid: 21145003
references.citation: Cell. 2002 Sep 20;110(6):673-87
references.pmid: 12297042
references.citation: J Neurosci. 2006 Mar 29;26(13):3474-81
references.pmid: 16571754
references.citation: J Neurosci. 2006 Nov 22;26(47):12152-64
references.pmid: 17122040
references.citation: J Neurosci. 2010 Jul 28;30(30):9984-9
references.pmid: 20668183
references.citation: J Neurosci. 2006 Feb 22;26(8):2174-83
references.pmid: 16495444
references.citation: Commun Integr Biol. 2008;1(2):158-60
references.pmid: 19704879
references.citation: Cell. 2010 Oct 29;143(3):442-55
references.pmid: 21029865
references.citation: Genes Cells. 2002 Feb;7(2):187-97
references.pmid: 11895482
references.citation: Neuron. 2006 Apr 20;50(2):233-45
references.pmid: 16630835
references.citation: Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4057-62
references.pmid: 23345436
references.citation: J Neurosci. 2013 Sep 4;33(36):14617-28
references.pmid: 24005312
references.citation: Cell. 2010 May 28;141(5):908, 908.e1
references.pmid: 20510934
references.citation: J Neurosci. 2005 Jan 5;25(1):260-70
references.pmid: 15634790
references.citation: Trends Cell Biol. 2007 May;17(5):230-8
references.pmid: 17420126
references.citation: Biochem Cell Biol. 2004 Dec;82(6):664-75
references.pmid: 15674434
references.citation: Nat Commun. 2013;4:2136
references.pmid: 23868368
references.citation: J Neurosci. 2004 Feb 18;24(7):1565-77
references.pmid: 14973228
references.citation: J Neuropsychiatry Clin Neurosci. 1990 Fall;2(4):413-7
references.pmid: 2136394
references.citation: Biol Cell. 2010 Jun 30;102(8):479-88
references.pmid: 20497124
references.citation: Genomics. 2003 Apr;81(4):411-21
references.pmid: 12676565
references.citation: Nature. 2003 Jun 26;423(6943):939-48
references.pmid: 12827191
references.citation: EMBO J. 2000 Jun 15;19(12):2775-85
references.pmid: 10856223
references.citation: Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a003079
references.pmid: 20066100
references.citation: Nature. 2001 May 17;411(6835):317-21
references.pmid: 11357135
references.citation: J Biol Chem. 2012 Feb 10;287(7):4470-84
references.pmid: 22174418
references.citation: Hum Mol Genet. 2009 Mar 1;18(5):988-96
references.pmid: 18945720
references.citation: Neuron. 2008 Jul 10;59(1):56-69
references.pmid: 18614029
references.citation: Neural Dev. 2009 May 18;4:17
references.pmid: 19450252
references.citation: Brain. 2012 Jul;135(Pt 7):2140-54
references.pmid: 22637581
references.citation: Neuropharmacology. 2013 Feb;65:232-43
references.pmid: 23123677
references.citation: Nature. 2009 May 28;459(7246):528-33
references.pmid: 19404256
references.citation: Cell. 1995 May 5;81(3):435-43
references.pmid: 7736595
references.citation: Neural Dev. 2011 May 04;6:21
references.pmid: 21542907
references.citation: Exp Neurol. 1998 Nov;154(1):1-11
references.pmid: 9875262
references.citation: Semin Cell Dev Biol. 2012 Feb;23(1):58-64
references.pmid: 22044884
references.citation: J Biol Chem. 2011 Jan 28;286(4):2762-73
references.pmid: 21084300
references.citation: J Comp Neurol. 2008 Sep 1;510(1):47-67
references.pmid: 18615557
references.citation: J Biol Chem. 2010 Apr 30;285(18):13966-78
references.pmid: 20139422
references.citation: Nature. 2008 Oct 16;455(7215):903-11
references.pmid: 18923512
references.citation: J Cell Sci. 2009 Jan 15;122(Pt 2):159-63
references.pmid: 19118207
references.citation: Mol Psychiatry. 2010 Jan;15(1):4-6
references.pmid: 20029406
references.citation: J Neurobiol. 2002 Jun 5;51(3):190-204
references.pmid: 11984841
references.citation: J Comp Neurol. 2008 Mar 10;507(2):1228-44
references.pmid: 18181141
references.citation: Neuron. 2001 Dec 20;32(6):1027-40
references.pmid: 11754835
references.citation: J Biol Chem. 2004 May 14;279(20):21003-11
references.pmid: 15020595
references.citation: Neuropsychopharmacology. 2013 Mar;38(4):628-38
references.pmid: 23169347
references.citation: Annu Rev Public Health. 2007;28:235-58
references.pmid: 17367287
references.citation: J Neurosci. 1986 Feb;6(2):605-12
references.pmid: 3512794
references.citation: J Biol Chem. 2012 Mar 16;287(12):9346-59
references.pmid: 22282498
references.citation: Nat Neurosci. 2011 Feb;14(2):181-9
references.pmid: 21186356
references.citation: Mol Cell Neurosci. 2009 Dec;42(4):466-83
references.pmid: 19796685
references.citation: Hum Mol Genet. 2004 Jul 15;13(14):1471-7
references.pmid: 15150161
references.citation: Neuron. 2005 Oct 20;48(2):229-36
references.pmid: 16242404
references.citation: Mol Psychiatry. 1999 Sep;4(5):467-75
references.pmid: 10523820
references.citation: Eur J Neurosci. 2012 Aug;36(4):2461-9
references.pmid: 22748100
references.citation: Structure. 2011 Jun 8;19(6):779-89
references.pmid: 21620716
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20947-52
references.pmid: 19098102
references.citation: Science. 2008 Jul 11;321(5886):218-23
references.pmid: 18621663
references.citation: J Neurosci. 2000 Mar 15;20(6):2238-46
references.pmid: 10704499
references.citation: Neuron. 2007 Dec 20;56(6):992-1003
references.pmid: 18093522
references.citation: Neuron. 2000 Apr;26(1):207-17
references.pmid: 10798405
references.citation: Dev Dyn. 2005 Jan;232(1):1-10
references.pmid: 15580616
references.citation: Neuropharmacology. 2012 Jan;62(1):78-88
references.pmid: 21903109
references.citation: Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2785-9
references.pmid: 7708724
references.citation: J Neurochem. 2007 May;101(4):865-82
references.pmid: 17254012
references.citation: J Cell Biol. 1996 Nov;135(3):767-79
references.pmid: 8909549
references.citation: Biochem Biophys Res Commun. 2006 Jan 13;339(2):687-94
references.pmid: 16332460
references.citation: Cell. 2000 Jun 9;101(6):657-69
references.pmid: 10892652
references.citation: Genes Cells. 2003 Dec;8(12):985-94
references.pmid: 14750953
references.citation: J Neurochem. 2006 Apr;97 Suppl 1:16-23
references.pmid: 16635246
references.citation: Am J Hum Genet. 2008 Oct;83(4):504-10
references.pmid: 18940311
references.citation: Biochem J. 2009 May 1;419(3):519-31
references.pmid: 19356150
references.citation: Mol Cell Neurosci. 1996;8(1):53-69
references.pmid: 8923455
references.citation: J Neurosci. 2007 Oct 17;27(42):11279-88
references.pmid: 17942722
references.citation: J Neurochem. 2006 May;97(3):652-61
references.pmid: 16515543
references.citation: Cancer Sci. 2003 Aug;94(8):655-67
references.pmid: 12901789
references.citation: Mol Psychiatry. 2006 Apr;11(4):372-83
references.pmid: 16402135
references.citation: Adv Exp Med Biol. 2012;970:97-128
references.pmid: 22351053
references.citation: Mol Cell Neurosci. 2007 Feb;34(2):121-36
references.pmid: 17126027
references.citation: Curr Opin Cell Biol. 2007 Oct;19(5):593-602
references.pmid: 17942295
references.citation: J Biol Chem. 1998 Dec 11;273(50):33354-9
references.pmid: 9837910
references.citation: Nat Neurosci. 2005 Apr;8(4):458-67
references.pmid: 15750591
references.citation: Hum Genet. 2011 Jan;129(1):59-70
references.pmid: 20963441
references.citation: J Biol Chem. 2002 Dec 20;277(51):49976-81
references.pmid: 12376527
references.citation: PLoS One. 2013;8(2):e56897
references.pmid: 23418609
references.citation: Nat Neurosci. 2012 Jan 29;15(3):389-98, S1-2
references.pmid: 22286174
references.citation: Nat Neurosci. 2009 Apr;12(4):428-37
references.pmid: 19252495
references.citation: Eur J Pharmacol. 2000 Sep 29;405(1-3):385-95
references.pmid: 11033343
references.citation: J Neurosci. 2013 Jul 17;33(29):11949-59
references.pmid: 23864682
references.citation: Neuron. 2009 Mar 12;61(5):734-49
references.pmid: 19285470
references.citation: J Cell Biol. 2010 May 3;189(3):589-600
references.pmid: 20440002
references.citation: Neuron. 1996 Sep;17(3):423-34
references.pmid: 8816706
references.citation: Science. 2005 Feb 25;307(5713):1324-8
references.pmid: 15681343
references.citation: Semin Cell Dev Biol. 2012 Feb;23(1):35-42
references.pmid: 22044883
references.citation: Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13479-84
references.pmid: 17679699
references.citation: Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12957-62
references.pmid: 9371782
references.citation: Neuron. 2011 Jan 27;69(2):287-303
references.pmid: 21262467
references.citation: EMBO J. 2011 Sep 16;30(23):4728-38
references.pmid: 21926970
references.citation: Neuron. 2003 Apr 10;38(1):9-12
references.pmid: 12691659
references.citation: Nat Neurosci. 2007 Jan;10(1):19-26
references.pmid: 17189949
references.citation: Biol Open. 2013 Mar 15;2(3):324-34
references.pmid: 23519440
references.citation: Neurobiol Aging. 2014 Apr;35(4):746-56
references.pmid: 24211009
references.citation: Neuroscience. 1997 May;78(1):99-110
references.pmid: 9135092
references.citation: Nat Struct Biol. 1999 May;6(5):486-93
references.pmid: 10331878
references.citation: J Neurosci. 1998 Sep 1;18(17):6892-904
references.pmid: 9712659