title: [Neoadjuvant and adjuvant chemotherapy with paclitaxel, cisplatin and 5-fluorouracil for advanced penile cancer: a case report].
abstract: 54-year-old male was introduced to our hospital in January 2012 for surgical treatment and chemotherapy. The pathological examination revealed well differentiated squamous cell carcinoma of the penis. Computed tomography and magnetic resonance imaging indicated right inguinal and pelvic lymphadenopathy. We diagnosed the tumor to be unresectable radically and administered paclitaxel, cisplatin and 5-fluorouracil (TPF) as neoadjuvant chemotherapy. After 3 courses of chemotherapy, the size of lymphadenopathy had become small enough to allow curative surgical treatment. Partial penectomy and lymph node dissection were performed after neoadjuvant chemotherapy. For 12 months after this radical treatment, the patient has been healthy with no local resurrence and no distant metastatic lesion. TPF chemotherapy for unresectable nodal metastasis from squamous cell carcinoma of penis was suggested to be effective.
authors.affiliation: The Department of Urology, Yokohama City University Medical Center.
authors.forename: Daiji
authors.initials: D
authors.lastname: Takamoto
authors.affiliation: The Department of Urology, Yokohama City University Medical Center.
authors.forename: Jun
authors.initials: J
authors.lastname: Kasuga
authors.affiliation: The Department of Urology, Yokohama City University Medical Center.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yumura
authors.affiliation: The Department of Urology, Yokohama City University Medical Center.
authors.forename: Mituyuki
authors.initials: M
authors.lastname: Koizumi
authors.affiliation: The Department of Urology, Yokohama City University Medical Center.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hanai
authors.affiliation: The Department of Urology, Yokohama City University Medical Center.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ishida
authors.affiliation: The Department of Urology, Yokohama City University Medical Center.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hattori
authors.affiliation: The Department of Urology, Yokohama City University Medical Center.
authors.forename: Jyunichi
authors.initials: J
authors.lastname: Teranishi
authors.affiliation: The Department of Urology, Yokohama City University Medical Center.
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Miyoshi
authors.affiliation: The Department of Urology, Yokohama City University Medical Center.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kondo
authors.affiliation: The Department of Urology, Yokohama City University Medical Center.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Noguchi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010412:Penile Neoplasms / Q000628:therapy*; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D002945:Cisplatin; D005472:Fluorouracil