title: A case of osmotic demyelination syndrome occurred after the correction of severe hyponatraemia in hyperemesis gravidarum.
abstract: BACKGROUND
  Osmotic demyelination syndrome (ODS) may be observed as a result of a rapid change in serum osmolarity, such as that induced by an overly rapid correction of serum sodium levels in hyponatraemic patients.
  
  
  METHODS
  We describe the case of a 21-year-old woman who was hospitalized at week 10 of gestation because of severe hyperemesis. At admission the patient appeared restless and confused and severe hyponatraemia (serum sodium 107 mmol/L) and hypokalemia (serum potassium 1.1 mmol/L) were detected. Active and simultaneous correction of these imbalances led to an overly rapid increase of serum sodium levels (17 mmol/L in the first 24 hours). Isotonic saline solution was stopped and replaced by 5% dextrose solution infusion. However, the neurological alterations worsened and the radiological features were consistent with the diagnosis of extra-pontine ODS. Steroids were administered intravenously with progressive improvement of biochemical and clinical abnormalities. At the time of discharge, 20 days later, the patient was able to walk and eat autonomously with only minimal external support.
  
  
  CONCLUSIONS
  This report illustrates an unusual case of ODS, occurred after an excessive rate of correction of hyponatraemia obtained with isotonic saline infusion. Hypokaliemia and its active correction very likely played a crucial role in facilitating the onset of ODS. This interesting aspect will be explained in detail in the article. A more cautious and thoughtful correction of electrolyte alterations, would have probably prevented the onset of ODS in this patient. Physicians should be aware of the possibly fatal consequences that an exceedingly rapid change of serum osmolarity may have and should strictly follow the known safety measures in order to prevent it to occur.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Corona
authors.forename: Luigi
authors.initials: L
authors.lastname: Simonetti
authors.forename: Corinna
authors.initials: C
authors.lastname: Giuliani
authors.forename: Alessandra
authors.initials: A
authors.lastname: Sforza
authors.affiliation: Department of Experimental and Clinical Biomedical Sciences, Endocrine Unit, University of Florence, Florence, Italy. alessandro.peri@unifi.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Peri
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