title: Molecular players involved in temperature-dependent sex determination and sex differentiation in Teleost fish.
abstract: The molecular mechanisms that underlie sex determination and differentiation are conserved and diversified. In fish species, temperature-dependent sex determination and differentiation seem to be ubiquitous and molecular players involved in these mechanisms may be conserved. Although how the ambient temperature transduces signals to the undifferentiated gonads remains to be elucidated, the genes downstream in the sex differentiation pathway are shared between sex-determining mechanisms. In this paper, we review recent advances on the molecular players that participate in the sex determination and differentiation in fish species, by putting emphasis on temperature-dependent sex determination and differentiation, which include temperature-dependent sex determination and genetic sex determination plus temperature effects. Application of temperature-dependent sex differentiation in farmed fish and the consequences of temperature-induced sex reversal are discussed.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Shen
authors.affiliation: Aquaculture Genetics and Breeding Laboratory, The Ohio State University South Centers, Piketon, Ohio 45661, USA. wang.900@osu.edu.
authors.forename: Han-Ping
authors.initials: HP
authors.lastname: Wang
mesh_terms: D000818:Animals; D005260:Female; D005399:Fishes / Q000235:genetics*; D059647:Gene-Environment Interaction; D008297:Male; D010053:Ovary / Q000254:growth & development; D012733:Sex Differentiation / Q000235:genetics*; D013696:Temperature; D013737:Testis / Q000254:growth & development
references.citation: Mol Ecol. 2010 Feb;19(4):627-46
references.pmid: 20088884
references.citation: Mol Reprod Dev. 2010 Aug;77(8):679-86
references.pmid: 20653000
references.citation: Evolution. 2011 Jan;65(1):64-78
references.pmid: 20722730
references.citation: PLoS One. 2011;6(9):e24540
references.pmid: 21931746
references.citation: Fish Physiol Biochem. 2013 Feb;39(1):91-4
references.pmid: 22688449
references.citation: J Hered. 2005 Mar-Apr;96(2):150-4
references.pmid: 15710905
references.citation: Zoolog Sci. 2005 Jul;22(7):791-6
references.pmid: 16082168
references.citation: Sex Dev. 2010;4(1-2):16-28
references.pmid: 20145384
references.citation: Dev Dyn. 2002 May;224(1):39-50
references.pmid: 11984872
references.citation: Dev Biol. 2007 Jan 1;301(1):266-75
references.pmid: 17109839
references.citation: Development. 2010 Aug 1;137(15):2519-26
references.pmid: 20573695
references.citation: Am Nat. 2003 Apr;161(4):676-83
references.pmid: 12776892
references.citation: J Exp Zool A Comp Exp Biol. 2005 Sep 1;303(9):802-12
references.pmid: 16106412
references.citation: Genome Res. 2006 Jul;16(7):815-26
references.pmid: 16751340
references.citation: Conserv Biol. 2009 Feb;23(1):196-206
references.pmid: 18847438
references.citation: Mol Endocrinol. 2007 Mar;21(3):712-25
references.pmid: 17192407
references.citation: Dev Dyn. 1999 Dec;216(4-5):411-9
references.pmid: 10633860
references.citation: PLoS One. 2009 Aug 07;4(8):e6548
references.pmid: 19662094
references.citation: Nat Genet. 2001 Dec;29(4):453-8
references.pmid: 11726932
references.citation: Development. 2004 Feb;131(4):933-42
references.pmid: 14736745
references.citation: Nature. 2002 May 30;417(6888):559-63
references.pmid: 12037570
references.citation: Trends Ecol Evol. 2007 Sep;22(9):441-3
references.pmid: 17640769
references.citation: J Mol Endocrinol. 2006 Jun;36(3):399-413
references.pmid: 16720712
references.citation: Semin Cell Dev Biol. 2009 May;20(3):256-63
references.pmid: 19121404
references.citation: Proc Biol Sci. 2012 Jan 7;279(1726):28-38
references.pmid: 21613294
references.citation: Endocrinology. 2010 Aug;151(8):3900-8
references.pmid: 20534725
references.citation: Evolution. 1992 Dec;46(6):1722-1730
references.pmid: 28567769
references.citation: Nature. 2009 Sep 10;461(7261):267-71
references.pmid: 19710650
references.citation: Mol Reprod Dev. 2001 Jul;59(3):265-76
references.pmid: 11424212
references.citation: Genome Res. 2003 Mar;13(3):382-90
references.pmid: 12618368
references.citation: Bioessays. 2004 Feb;26(2):120-32
references.pmid: 14745830
references.citation: Dev Dyn. 2008 Nov;237(11):3192-9
references.pmid: 18816438
references.citation: Genes Dev. 2000 Jul 15;14(14):1750-64
references.pmid: 10898790
references.citation: Biochem Biophys Res Commun. 2006 Dec 29;351(4):815-9
references.pmid: 17092483
references.citation: Reproduction. 2010 Sep;140(3):477-87
references.pmid: 20584991
references.citation: PLoS One. 2012;7(1):e29982
references.pmid: 22253846
references.citation: Gen Comp Endocrinol. 2005 May 15;142(1-2):102-10
references.pmid: 15862554
references.citation: Dev Dyn. 2003 Nov;228(3):480-9
references.pmid: 14579386
references.citation: Cell. 1983 Dec;35(2 Pt 1):381-92
references.pmid: 6317184
references.citation: J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):305-14
references.pmid: 11850237
references.citation: Biol Rev Camb Philos Soc. 2012 Nov;87(4):900-11
references.pmid: 22540898
references.citation: Biol Reprod. 2005 Nov;73(5):959-66
references.pmid: 16014816
references.citation: Gene Expr Patterns. 2005 Jun;5(5):655-67
references.pmid: 15939378
references.citation: Evolution. 2008 Jan;62(1):234-40
references.pmid: 18053078
references.citation: Science. 1981 Jul 31;213(4507):577-9
references.pmid: 17794845
references.citation: Curr Biol. 2003 Aug 19;13(16):1429-34
references.pmid: 12932328
references.citation: Genetics. 2007 Jun;176(2):1049-57
references.pmid: 17435246
references.citation: C R Acad Hebd Seances Acad Sci D. 1972 Jan 31;274(5):719-22
references.pmid: 4622404
references.citation: Endocr Rev. 2001 Oct;22(5):657-74
references.pmid: 11588147
references.citation: Dev Dyn. 2007 Jan;236(1):271-81
references.pmid: 17075875
references.citation: J Theor Biol. 2004 Mar 21;227(2):159-65
references.pmid: 14990380
references.citation: Trends Endocrinol Metab. 2003 Mar;14(2):91-7
references.pmid: 12591180
references.citation: Hum Mol Genet. 2005 Jul 15;14(14):2053-62
references.pmid: 15944199
references.citation: Dev Dyn. 2007 May;236(5):1329-38
references.pmid: 17393497
references.citation: PLoS One. 2013 Jun 07;8(6):e63599
references.pmid: 23762231
references.citation: Cell Microbiol. 2006 Jun;8(6):907-22
references.pmid: 16681834
references.citation: Dev Dyn. 2005 Mar;232(3):633-55
references.pmid: 15704101
references.citation: Dev Dyn. 2007 Nov;236(11):3155-66
references.pmid: 17937394
references.citation: Hum Mol Genet. 2004 Jun 1;13(11):1171-81
references.pmid: 15056605
references.citation: Gen Comp Endocrinol. 2008 Nov-Dec;159(2-3):178-87
references.pmid: 18799130
references.citation: J Exp Zool B Mol Dev Evol. 2006 Mar 15;306(2):134-9
references.pmid: 16217798
references.citation: Dev Genes Evol. 2005 Jun;215(6):297-305
references.pmid: 15818483
references.citation: Mol Biol Rep. 2012 Apr;39(4):4727-41
references.pmid: 21947950
references.citation: Dev Dyn. 2013 Apr;242(4):360-70
references.pmid: 23335256
references.citation: J Mol Endocrinol. 1999 Oct;23(2):167-76
references.pmid: 10514554
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3865-70
references.pmid: 17360444
references.citation: Nature. 2008 Jun 12;453(7197):930-4
references.pmid: 18454134
references.citation: Zoolog Sci. 2005 Sep;22(9):985-8
references.pmid: 16219978
references.citation: J Endocrinol. 2007 Jul;194(1):223-41
references.pmid: 17592036
references.citation: Biochem Biophys Res Commun. 2006 May 26;344(1):353-61
references.pmid: 16630569
references.citation: Dev Biol. 2001 Mar 1;231(1):149-63
references.pmid: 11180959
references.citation: Nat Genet. 1996 Sep;14(1):62-8
references.pmid: 8782821
references.citation: Gen Comp Endocrinol. 2008 Aug;158(1):131-7
references.pmid: 18599055
references.citation: J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):381-6
references.pmid: 14623534
references.citation: J Exp Zool A Ecol Genet Physiol. 2007 Nov 1;307(11):625-36
references.pmid: 17726668
references.citation: Mol Cell Endocrinol. 2003 Dec 15;211(1-2):21-31
references.pmid: 14656472
references.citation: Genomics. 2001 Sep;77(1-2):8-17
references.pmid: 11543627
references.citation: Fish Physiol Biochem. 2005 Apr;31(2-3):215-26
references.pmid: 20035461
references.citation: Bioessays. 2005 Sep;27(9):937-45
references.pmid: 16108068
references.citation: Cell. 1988 Sep 23;54(7):1019-31
references.pmid: 3046751
references.citation: Sex Dev. 2007;1(4):255-70
references.pmid: 18391536
references.citation: Comp Biochem Physiol C Toxicol Pharmacol. 2001 Dec;130(4):399-409
references.pmid: 11738628
references.citation: Mol Reprod Dev. 2003 Nov;66(3):211-7
references.pmid: 14502599
references.citation: PLoS Genet. 2011 Dec;7(12):e1002447
references.pmid: 22242011
references.citation: Environ Sci Technol. 2007 Sep 1;41(17):6305-10
references.pmid: 17937319
references.citation: Biochem Biophys Res Commun. 2007 Aug 10;359(4):935-40
references.pmid: 17574208
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11987-92
references.pmid: 16877546
references.citation: J Mol Evol. 2004 Aug;59(2):190-203
references.pmid: 15486693
references.citation: Integr Comp Biol. 2013 Dec;53(6):877-87
references.pmid: 23892413
references.citation: Endocrinology. 1998 Apr;139(4):2179-89
references.pmid: 9529008
references.citation: J Mol Endocrinol. 2004 Dec;33(3):705-15
references.pmid: 15591029
references.citation: Cell. 1994 Dec 16;79(6):1111-20
references.pmid: 8001137
references.citation: Dev Biol. 2007 May 1;305(1):120-32
references.pmid: 17350610
references.citation: Sex Dev. 2008;2(6):316-24
references.pmid: 19276634
references.citation: Gen Comp Endocrinol. 1985 Feb;57(2):216-22
references.pmid: 3979803
references.citation: Evol Dev. 2006 Sep-Oct;8(5):424-32
references.pmid: 16925678
references.citation: Conserv Biol. 2013 Feb;27(1):229-34
references.pmid: 22891785
references.citation: FEBS J. 2011 Apr;278(7):1002-9
references.pmid: 21281448
references.citation: Mol Reprod Dev. 2006 Dec;73(12):1481-90
references.pmid: 16929526
references.citation: Biol Reprod. 2010 Sep;83(3):443-53
references.pmid: 20505169
references.citation: Dev Dyn. 2004 Oct;231(2):387-95
references.pmid: 15366016
references.citation: Sex Dev. 2009;3(2-3):118-35
references.pmid: 19684457
references.citation: Mol Endocrinol. 2010 May;24(5):1024-36
references.pmid: 20207836
references.citation: J Theor Biol. 2012 Feb 7;294:185
references.pmid: 22094362
references.citation: Genetics. 2012 May;191(1):163-70
references.pmid: 22367037
references.citation: Mol Cell Endocrinol. 2000 Jun;164(1-2):169-81
references.pmid: 11026568
references.citation: Science. 1990 Dec 14;250(4987):1556-8
references.pmid: 17818284
references.citation: Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2955-9
references.pmid: 22323585
references.citation: Semin Cell Dev Biol. 2005 Dec;16(6):694-703
references.pmid: 16039883
references.citation: J Genet. 2007 Aug;86(2):85-91
references.pmid: 17968136
references.citation: Integr Comp Biol. 2013 Oct;53(4):755-65
references.pmid: 23946267
references.citation: Sex Dev. 2007;1(2):138-46
references.pmid: 18391524
references.citation: Dev Dyn. 2004 Nov;231(3):518-26
references.pmid: 15376325
references.citation: Biochim Biophys Acta. 2000 Sep 7;1493(1-2):180-7
references.pmid: 10978520
references.citation: J Evol Biol. 2013 Dec;26(12):2544-57
references.pmid: 24118347
references.citation: Genetics. 2006 Aug;173(4):2083-90
references.pmid: 16702419
references.citation: J Mol Evol. 2003;57 Suppl 1:S241-9
references.pmid: 15008421
references.citation: Evol Appl. 2013 Apr;6(3):486-96
references.pmid: 23745140
references.citation: Biochem Biophys Res Commun. 2004 Sep 17;322(2):508-13
references.pmid: 15325259
references.citation: Environ Sci Technol. 2006 May 1;40(9):3118-22
references.pmid: 16719120
references.citation: Nat Genet. 2001 Feb;27(2):159-66
references.pmid: 11175783
references.citation: Curr Biol. 1996 Feb 1;6(2):149-62
references.pmid: 8673462
references.citation: J Exp Biol. 2006 Mar;209(Pt 6):994-1003
references.pmid: 16513925
references.citation: J Exp Zool. 2002 Apr 1;292(5):494-505
references.pmid: 11857484
references.citation: Curr Biol. 2012 Aug 7;22(15):1423-8
references.pmid: 22727696
references.citation: Gen Comp Endocrinol. 2007 Jan 1;150(1):164-73
references.pmid: 16962121
references.citation: Cytogenet Genome Res. 2007;117(1-4):165-73
references.pmid: 17675857
references.citation: Mol Biol Evol. 2001 Apr;18(4):542-50
references.pmid: 11264405
references.citation: BMC Genomics. 2012 Mar 19;13:96
references.pmid: 22424280
references.citation: Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7487-90
references.pmid: 8052608
references.citation: J Steroid Biochem Mol Biol. 2001 Nov;78(5):427-39
references.pmid: 11738553
references.citation: Mol Cell Endocrinol. 2001 Jun 20;179(1-2):25-32
references.pmid: 11420127
references.citation: J Theor Biol. 2006 Jul 21;241(2):333-41
references.pmid: 16406425
references.citation: Cell Tissue Res. 2005 Oct;322(1):107-15
references.pmid: 15983782
references.citation: Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11778-83
references.pmid: 12193652
references.citation: PLoS One. 2013 Jun 04;8(6):e65269
references.pmid: 23750249
references.citation: Biochem Biophys Res Commun. 2005 Aug 5;333(3):729-36
references.pmid: 15963466
references.citation: Mol Genet Metab. 2006 Jul;88(3):225-34
references.pmid: 16647286
references.citation: Mol Biol Evol. 2004 Jun;21(6):1146-51
references.pmid: 15014147
references.citation: Sex Dev. 2007;1(1):2-11
references.pmid: 18391511
references.citation: J Bone Miner Metab. 2011 Jul;29(4):390-5
references.pmid: 21594584
references.citation: Dev Dyn. 2013 Apr;242(4):339-53
references.pmid: 23335327
references.citation: Nature. 1987 Apr 2-8;326(6112):496-8
references.pmid: 3561487
references.citation: C R Acad Hebd Seances Acad Sci D. 1971 Jun 14;272(24):3071-4
references.pmid: 4997326
references.citation: Biol Reprod. 2008 Feb;78(2):333-41
references.pmid: 17942796
references.citation: Cytogenet Genome Res. 2003;101(3-4):302-8
references.pmid: 14684999
references.citation: Mol Reprod Dev. 2002 Sep;63(1):5-16
references.pmid: 12211055
references.citation: Dev Dyn. 2008 Jan;237(1):297-306
references.pmid: 18095345
references.citation: Annu Rev Genomics Hum Genet. 2011;12:391-406
references.pmid: 21801024
references.citation: Mol Endocrinol. 2007 Nov;21(11):2750-63
references.pmid: 17684113
references.citation: Nat Genet. 2001 Jul;28(3):216-7
references.pmid: 11431689
references.citation: Gen Comp Endocrinol. 2010 Feb 1;165(3):352-66
references.pmid: 19289125
references.citation: Gene. 2008 Mar 15;410(2):249-58
references.pmid: 18242010
references.citation: Development. 2004 May;131(9):1891-901
references.pmid: 15056615
references.citation: Mol Reprod Dev. 2008 Mar;75(3):472-6
references.pmid: 17474097
references.citation: PLoS Genet. 2012;8(7):e1002798
references.pmid: 22807687
references.citation: Gene. 1997 Nov 20;202(1-2):167-70
references.pmid: 9427561
references.citation: Gen Comp Endocrinol. 2011 Dec 1;174(3):259-68
references.pmid: 21906596
references.citation: Biol Reprod. 2003 Feb;68(2):560-70
references.pmid: 12533420
references.citation: Nature. 1998 Feb 12;391(6668):691-5
references.pmid: 9490411
references.citation: Integr Comp Biol. 2008 Oct;48(4):476-85
references.pmid: 21669808
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2469-74
references.pmid: 18268317
references.citation: Nat Genet. 2000 Dec;26(4):490-4
references.pmid: 11101852
references.citation: Dev Biol. 1999 Nov 15;215(2):208-20
references.pmid: 10545231
references.citation: Biol Reprod. 2006 Jan;74(1):195-201
references.pmid: 16207837
references.citation: Nature. 1994 Dec 8;372(6506):525-30
references.pmid: 7990924
references.citation: Physiol Rev. 1997 Jul;77(3):591-625
references.pmid: 9234959
references.citation: Gene. 2004 Mar 17;328:177-86
references.pmid: 15019997
references.citation: J Steroid Biochem Mol Biol. 1997 Apr;61(3-6):387-92
references.pmid: 9365215
references.citation: Endocrinology. 2010 Mar;151(3):1331-40
references.pmid: 20056824
references.citation: Cell. 1989 Mar 24;56(6):997-1010
references.pmid: 2493994
references.citation: Nature. 1999 Dec 9;402(6762):601-2
references.pmid: 10604464
references.citation: Curr Biol. 2004 Sep 21;14(18):1664-9
references.pmid: 15380069
references.citation: Semin Cell Dev Biol. 2009 May;20(3):293-303
references.pmid: 19022389
references.citation: Nat Rev Genet. 2001 Mar;2(3):175-85
references.pmid: 11256069
references.citation: Science. 1998 Sep 25;281(5385):1990-4
references.pmid: 9748152
references.citation: C R Seances Soc Biol Fil. 1966;160(3):620-2
references.pmid: 4224426
references.citation: Sex Dev. 2009;3(4):225-32
references.pmid: 19752602
references.citation: PLoS One. 2008 Jul 30;3(7):e2837
references.pmid: 18665231
references.citation: Genesis. 2000 Mar;26(3):174-8
references.pmid: 10705377
references.citation: Development. 1995 Jun;121(6):1603-14
references.pmid: 7600978
references.citation: Dev Dyn. 1998 Aug;212(4):522-32
references.pmid: 9707325