title: Pancreatic hyperenzymemia is associated with bacterial culture positivity, more severe and right-sided colitis.
abstract: OBJECTIVE
  Several studies reported pancreatic hyperenzymemia (PHE) related to acute colitis. However, there is no consensus on its clinical significance. This study was addressed to find the clinical significance of PHE in acute colitis.
  
  
  METHODS
  Pancreatic hyperenzymemia was defined as abnormal increase in serum concentrations of the pancreatic enzymes by three times of normal upper range without definite pancreatic symptoms and evidence of pancreatitis at abdominal CT imaging of pancreatic disease. And clinical and laboratory and biologic parameters of PHE group and normal pancreatic enzymemia (NPE) group were compared.
  
  
  RESULTS
  A total of 1,069 patients admitted to hospitals due to acute colitis were analyzed. Of these patients, 2.99 % (32/1,069) showed PHE. PHE group showed more severe symptoms and had longer hospital stays than the NPE group (12.15 vs. 4.59 days; P < 0.001). Multivariable analysis showed that right-sided colitis (OR 2.846; 95 % CI 1.122-7.224; P = 0.028) and culture positivity (OR 3.346; 95 % CI 1.119-10.008; P = 0.031) are associated with PHE during acute colitis. Also, PHE group was more common when a microorganism could be identified in the cultures (28.1 vs. 7.0 %; P = 0.003), especially blood culture. Among patients with positive cultures, Salmonella spp. had a positive correlation with the right-sided colitis and PHE (amylase P = 0.002; lipase P = 0.029), Salmonella serovar typhimurium (group B) was especially related to increased serum lipase but not to increased serum amylase (lipase; P = 0.041: amylase; P = 0.485).
  
  
  CONCLUSIONS
  Pancreatic hyperenzymemia is associated with right-sided colitis, bacterial culture positivity, and severe acute colitis.
authors.affiliation: Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School and Hospital, 634-18 Keumam-dong, Dukjin-gu, Chonju, Jeonbuk, 561-712, South Korea.
authors.forename: Bum Su
authors.initials: BS
authors.lastname: Choung
authors.forename: Seong Hun
authors.initials: SH
authors.lastname: Kim
authors.forename: Seung Young
authors.initials: SY
authors.lastname: Seo
authors.forename: In Hee
authors.initials: IH
authors.lastname: Kim
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Kim
authors.forename: Seung-Ok
authors.initials: SO
authors.lastname: Lee
authors.forename: Soo Teik
authors.initials: ST
authors.lastname: Lee
mesh_terms: D000208:Acute Disease; D000681:Amylases / Q000097:blood*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003092:Colitis / Q000097:blood* / Q000150:complications; D044682:Colon, Ascending; D006801:Humans; D007958:Leukocyte Count; D008049:Lipase / Q000097:blood*; D010182:Pancreatic Diseases / Q000097:blood / Q000201:enzymology* / Q000382:microbiology; D012189:Retrospective Studies; D012480:Salmonella Infections / Q000097:blood* / Q000150:complications / Q000382:microbiology; D012477:Salmonella enteritidis / Q000302:isolation & purification; D012486:Salmonella typhimurium / Q000302:isolation & purification; D012720:Severity of Illness Index
chemical_list: D002097:C-Reactive Protein; D008049:Lipase; D000681:Amylases
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