title: Serum-soluble HLA-G is associated with specific IgE in patients with allergic rhinitis and asthma.
abstract: Allergic rhinitis (AR) and allergic asthma (AA) are characterized by T helper (Th)2-polarized immune response. Soluble human leukocyte antigen G (sHLA-G) molecule plays an immunomodulatory activity. Previously, it has been reported that children with AR or AA had higher sHLA-G levels in comparison with normal subjects. Thus, the present study aimed at confirming these data in adults and investigating whether there was a relationship between serum sHLA-G levels and serum IgE levels, in patients with AR or AA. One hundred twenty symptomatic patients, suffering from respiratory symptoms, were enrolled: 45 non-allergic and 75 allergic. A group of 44 healthy subjects was considered as control. Serum sHLA-G levels and serum allergen-specific IgE were determined by immunoenzymatic methods. Allergic patients had significantly higher levels of sHLA-G molecules than non-allergic patients and normal controls (p<0.0001). There was no difference between AR and AA. sHLA-G moderately related with allergen-specific IgE both in AR (r=0.468) and AA patients (r=0.479). The present study confirms that serum sHLA-G molecules are significantly increased in allergic disease and demonstrates that sHLA-G levels are related with allergen-specific IgE levels.
authors.affiliation: IRCCS, Azienda Ospedaliera Universitaria San Martino, Viale Benedetto XV 6, 16132, Genoa, Italy, gio.cip@libero.it.
authors.forename: G
authors.initials: G
authors.lastname: Ciprandi
authors.forename: A
authors.initials: A
authors.lastname: Corsico
authors.forename: P
authors.initials: P
authors.lastname: Pisati
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000097:blood* / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D005260:Female; D059951:HLA-G Antigens / Q000097:blood*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D065631:Rhinitis, Allergic / Q000097:blood* / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D059951:HLA-G Antigens; D007073:Immunoglobulin E
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