title: A Multicenter prospective study of poor-grade aneurysmal subarachnoid hemorrhage (AMPAS): observational registry study.
abstract: BACKGROUND
  Poor-grade aneurysmal subarachnoid hemorrhage (aSAH) is associated with very high mortality and morbidity. Our limited knowledge on predictors of long-term outcome in poor-grade patients with aSAH definitively managed comes from retrospective and prospective studies of small case series of patients in single center. The purpose of the AMPAS is to determine the long-term outcomes in poor-grade patients with different managements within different time after aSAH, and identify the independent predictors of the outcome that help guide the decision on definitive management.
  
  
  METHODS
  The AMPAS study is a prospective, multicenter, observational registry of consecutive hospitalized patients with poor grade aSAH (WFNS grade IV and V). The aim is to enroll at least 226 poor-grade patients in 11 high-volume medical centers (eg, >150 aSAH cases per year) affiliated to different universities in China. This study will describe poor grade patients and aneurysm characteristics, treatment strategies (modality and time of definitive management), hospitalization complications and outcomes evolve over time. The definitive management is ruptured aneurysm treatment. Outcomes at 3, 6, 12 months after the management were measured using the Glasgow Outcome Scale and the Modified Rankin Scale.
  
  
  CONCLUSIONS
  The AMPAS is the first prospective, multicenter, observational registry of poor grade aSAH with any management. This study will contribute to a better understanding of significant predictors of outcome in poor grade patients and help guide future treatment of the worst patients after aSAH.
  
  
  BACKGROUND
  Chinese Clinical Trial Registry: ChiCTR-TNRC-10001041.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhao
authors.forename: Xianxi
authors.initials: X
authors.lastname: Tan
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Kuang
authors.initials: K
authors.lastname: Zheng
authors.forename: Zequn
authors.initials: Z
authors.lastname: Li
authors.forename: Ye
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: Department of Neurosurgery, The first affiliated hospital of Wenzhou Medical University, Wenzhou, China. zhongming158@sohu.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhong
mesh_terms: D002681:China; D006801:Humans; D011446:Prospective Studies; D012042:Registries; D012107:Research Design; D013345:Subarachnoid Hemorrhage / Q000473:pathology* / Q000628:therapy*; D016896:Treatment Outcome
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