title: Coiled fiber scaffolds embedded with gold nanoparticles improve the performance of engineered cardiac tissues.
abstract: Coiled perimysial fibers within the heart muscle provide it with the ability to contract and relax efficiently. Here, we report on a new nanocomposite scaffold for cardiac tissue engineering, integrating coiled electrospun fibers with gold nanoparticles. Cultivation of cardiac cells within the hybrid scaffolds promoted cell organization into elongated and aligned tissues generating a strong contraction force, high contraction rate and low excitation threshold.
authors.affiliation: The Laboratory for Tissue Engineering and Regenerative Medicine, Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel. tdvir@post.tau.ac.il.
authors.forename: Sharon
authors.initials: S
authors.lastname: Fleischer
authors.forename: Michal
authors.initials: M
authors.lastname: Shevach
authors.forename: Ron
authors.initials: R
authors.lastname: Feiner
authors.forename: Tal
authors.initials: T
authors.lastname: Dvir
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D055119:Elastic Modulus; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D032383:Myocytes, Cardiac / Q000737:chemistry* / Q000166:cytology / Q000378:metabolism*; D057139:Nanofibers / Q000737:chemistry*; D051381:Rats; D013499:Surface Properties; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D006046:Gold