title: A transition metal-free Minisci reaction: acylation of isoquinolines, quinolines, and quinoxaline.
abstract: Transition metal-free acylation of isoquinoline, quinoline, and quinoxaline derivatives has been developed employing a cross dehydrogenative coupling (CDC) reaction with aldehydes using substoichiometric amount of TBAB (tetrabutylammonium bromide, 30 mol %) and K2S2O8 as an oxidant. This intermolecular acylation of electron-deficient heteroarenes provides an easy access and a novel acylation method of heterocyclic compounds. The application of this CDC strategy for acylation strategy has been illustrated in synthesizing isoquinoline-derived natural products.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka, India.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Siddaraju
authors.forename: Manjunath
authors.initials: M
authors.lastname: Lamani
authors.forename: Kandikere Ramaiah
authors.initials: KR
authors.lastname: Prabhu
mesh_terms: D000215:Acylation; D000447:Aldehydes / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000737:chemistry*; D011810:Quinoxalines / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D006571:Heterocyclic Compounds; D007546:Isoquinolines; D011804:Quinolines; D011810:Quinoxalines