title: Assessment of postural balance among individuals with Parkinson disease with and without effects from dopaminergic medications.
abstract: OBJECTIVE
  The objectives of the present study were to assess the effects of dopaminergic drugs on the postural balance of Parkinson disease (PD) patients and to ascertain whether their sway is greater along the mediolateral or the anteroposterior axis.
  
  
  METHODS
  Twenty-two patients awaiting operations for implantation of a deep brain stimulator at the neurology service of Hospital das Clínicas, University of São Paulo School of Medicine (HC-FMUSP), were assessed. All of them were assessed on the AccuSway portable force platform, through evaluation of the center of pressure. The patients stayed standing upright on both feet with the eyes open and closed for 60-sec periods. Center-of-pressure displacements along the mediolateral and anteroposterior axes and the displacement velocity and the elliptical area covered by 95% of the displacement were measured. Two assessments were made: without medication (at least 12 hrs after the last administration) and with the effects from levodopa.
  
  
  RESULTS
  The elliptical displacement area was greater when the patients were under the effects of the medication (P < 0.05). The center-of-pressure displacements were greater along the anteroposterior axis than along the mediolateral axis.
  
  
  CONCLUSIONS
  Levodopa increases the sway area of the Parkinson disease patients evaluated by static posturography.
authors.affiliation: From FMUSP and the Movement Study Laboratory (LEM), IOT-HC-FMUSP (JMD'AG); the Department of Experimental Physiopathology, University of São Paulo Medical School (FMUSP), the Movement Study Laboratory (LEM), Institute of Orthopedics and Traumatology (IOT), Hospital das Clinicas (HC), FMUSP, São Paulo, SP (NMSL, JPdS, CP, ACA).
authors.forename: Júlia Maria
authors.initials: JM
authors.lastname: D'Andréa Greve
authors.forename: Natália Mariana Silva
authors.initials: NM
authors.lastname: Luna
authors.forename: Juliana Plato
authors.initials: JP
authors.lastname: de Siqueira
authors.forename: Cristina
authors.initials: C
authors.lastname: Prota
authors.forename: Angélica Castilho
authors.initials: AC
authors.lastname: Alonso
mesh_terms: D000058:Accidental Falls / Q000517:prevention & control; D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy* / Q000601:surgery; D004856:Postural Balance / Q000187:drug effects*; D012016:Reference Values; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa