title: No association of pri-miR-143 rs41291957 polymorphism with the risk of congenital heart disease in a Chinese population.
abstract: MiR-143 plays an important role in the heart development of zebra fish. The rs41291957 variant located in the pri-miR-143 sequence is associated with colorectal carcinogenesis. Therefore, the authors hypothesized that rs41291957 in pri-miR-143 might be involved in the risk of sporadic congenital heart disease (CHD). The authors conducted a case-control study of CHD in a Chinese population to test their hypothesis by genotyping pri-miR-143 rs41291957 in 1,109 CHD cases and 915 non-CHD control subjects. Logistic regression analyses showed no significant association of genotype or allele frequencies of pri-miR-143 rs41291957 A/G polymorphism with the CHD cases in overall or various subtypes compared with the control group. To the authors' knowledge, this is the first study to investigate the relationship between miR-143 and CHD cases. The results demonstrated that rs41291957 in pri-miR-143 has no major role in genetic susceptibility to sporadic CHD, at least in the current study population.
authors.affiliation: Department of Cardiovascular Surgery,Union Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Yang
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Gao
authors.forename: Haiyan
authors.initials: H
authors.lastname: Luo
authors.forename: Qiuyu
authors.initials: Q
authors.lastname: Huang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wei
authors.forename: Guican
authors.initials: G
authors.lastname: Zhang
authors.forename: Guoying
authors.initials: G
authors.lastname: Huang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Su
authors.forename: Liangwan
authors.initials: L
authors.lastname: Chen
authors.forename: Cailing
authors.initials: C
authors.lastname: Lu
authors.forename: Juhua
authors.initials: J
authors.lastname: Yang
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006330:Heart Defects, Congenital / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment / Q000379:methods; D055815:Young Adult
chemical_list: C542359:MIRN143 microRNA, human; D035683:MicroRNAs
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