title: CD 152 gene polymorphisms and risk of osteosarcoma in Chinese population.
abstract: Osteosarcoma has become a health threat for adolescents and young adults. To identify the genetic risk factor for the malignancy is in urgent need. Several studies have investigated the role of CD 152 polymorphisms in osteosarcoma in a sample of Chinese population. However, the association is poorly defined due to lack of a sufficiently large sample. In this study, we performed a meta-analysis of all CD 152 polymorphisms that had been implicated in osteosarcoma to examine the association. We searched the electronic MEDLINE database until December 31, 2013, to identify the studies regarding the association between CD 152 polymorphisms and osteosarcoma. Inclusion criteria were followed in the selection of eligible study. The genotypic and allelic data were collected from all studies included to evaluate the risk of osteosarcoma (odds ratio, OR). We found statistically significant evidence of the studied CD 152 polymorphisms and increased risk of osteosarcoma in homozygous (OR = 1.79, 95 % CI = 1.40-2.29, P = 0.958), recessive (OR = 1.77, 95 % CI = 1.40-2.25, P = 0.899), and allele model (OR = 1.21, 95 % CI = 1.09-1.34, P = 1.000). This increased risk was also revealed in single nucleotide polymorphism (SNP) +49G>A and SNP 326G>A. Our meta-analysis indicates that there may be an association between CD 152 polymorphisms and risk of osteosarcoma in Chinese population. Further validation of the observation is necessary.
authors.affiliation: Department of Orthopedics, General Hospital of Jinan Military Commanding Region, Jinan, 250031, Shandong Province, China.
authors.forename: Zhengqi
authors.initials: Z
authors.lastname: Chang
authors.forename: Ruoxian
authors.initials: R
authors.lastname: Song
authors.forename: Songfeng
authors.initials: S
authors.lastname: Xu
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.forename: Xiuchun
authors.initials: X
authors.lastname: Yu
mesh_terms: D000483:Alleles; D044466:Asian People; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology; D060908:CTLA-4 Antigen / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D012516:Osteosarcoma / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide
chemical_list: D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human
references.citation: Nat Immunol. 2002 Nov;3(11):991-8
references.pmid: 12407406
references.citation: Cancer. 1995 Jan 1;75(1 Suppl):203-10
references.pmid: 8000997
references.citation: Oral Oncol. 2010 Jul;46(7):543-8
references.pmid: 20435510
references.citation: Immunity. 1994 Aug;1(5):405-13
references.pmid: 7882171
references.citation: Genet Test Mol Biomarkers. 2013 Jun;17(6):458-63
references.pmid: 23480667
references.citation: J Exp Med. 1994 Jan 1;179(1):299-304
references.pmid: 8270872
references.citation: Hum Immunol. 2007 Aug;68(8):698-704
references.pmid: 17678726
references.citation: Tumour Biol. 2013 Dec;34(6):3371-5
references.pmid: 23900675
references.citation: J Immunol. 2005 Dec 1;175(11):7746-54
references.pmid: 16301685
references.citation: Cancer Genet Cytogenet. 2006 Mar;165(2):114-20
references.pmid: 16527605
references.citation: Genet Test Mol Biomarkers. 2011 Jul-Aug;15(7-8):503-6
references.pmid: 21453059
references.citation: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references.pmid: 13655060
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: J Immunol. 1999 May 15;162(10):5813-20
references.pmid: 10229815
references.citation: Stat Med. 2002 Jun 15;21(11):1539-58
references.pmid: 12111919
references.citation: Mol Biol Rep. 2014 Feb;41(2):799-807
references.pmid: 24390231
references.citation: Biometrics. 1994 Dec;50(4):1088-101
references.pmid: 7786990
references.citation: DNA Cell Biol. 2011 Dec;30(12):1051-5
references.pmid: 21612409
references.citation: Cancer. 2009 Apr 1;115(7):1531-43
references.pmid: 19197972
references.citation: Mol Med Rep. 2013 Dec;8(6):1785-94
references.pmid: 24126947
references.citation: Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4712-7
references.pmid: 12682289
references.citation: J Immunol. 1991 Aug 1;147(3):1037-44
references.pmid: 1713603
references.citation: Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7
references.pmid: 12826605
references.citation: Immunol Rev. 2006 Aug;212:131-48
references.pmid: 16903911
references.citation: Annu Rev Immunol. 2005;23:515-48
references.pmid: 15771580
references.citation: Blood. 2002 Apr 15;99(8):2880-9
references.pmid: 11929778
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: Genet Test Mol Biomarkers. 2012 Oct;16(10):1236-40
references.pmid: 22905924
references.citation: Endocrine. 2014 Mar;45(2):325-30
references.pmid: 24078408
references.citation: Annu Rev Immunol. 2001;19:225-52
references.pmid: 11244036