title: Synthesis of heterocyclic-fused benzopyrans via the Pd(II)-catalyzed C-H alkenylation/C-O cyclization of flavones and coumarins.
abstract: An efficient and practical method for effecting a tandem C-H alkenylation/C-O cyclization has been achieved via the C-H functionalization of flavone derivatives. The synthetic utility of the one-pot sequence was demonstrated by obtaining convenient access to coumarin-annelated benzopyrans. The reaction scope for the transformation was found to be fairly broad, affording good yields of a wide range of flavone- or coumarin-fused benzopyran motifs, which are privileged structures in many biologically active compounds.
authors.affiliation: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Korea. hongorg@kaist.ac.kr.
authors.forename: Yechan
authors.initials: Y
authors.lastname: Kim
authors.forename: Youngtaek
authors.initials: Y
authors.lastname: Moon
authors.forename: Dahye
authors.initials: D
authors.lastname: Kang
authors.forename: Sungwoo
authors.initials: S
authors.lastname: Hong