title: Bacteriophages: an underestimated role in human and animal health?
abstract: Metagenomic approaches applied to viruses have highlighted their prevalence in almost all microbial ecosystems investigated. In all ecosystems, notably those associated with humans or animals, the viral fraction is dominated by bacteriophages. Whether they contribute to dysbiosis, i.e., the departure from microbiota composition in symbiosis at equilibrium and entry into a state favoring human or animal disease is unknown at present. This review summarizes what has been learnt on phages associated with human and animal microbiota, and focuses on examples illustrating the several ways by which phages may contribute to a shift to pathogenesis, either by modifying population equilibrium, by horizontal transfer, or by modulating immunity.
authors.affiliation: Institut National de la Recherche Agronomique, Micalis, UMR 1319 Jouy en Josas, France ; Agroparistech, Micalis, UMR 1319 Jouy en Josas, France.
authors.forename: Marianne
authors.initials: M
authors.lastname: De Paepe
authors.affiliation: Institut National de la Recherche Agronomique, Micalis, UMR 1319 Jouy en Josas, France ; Agroparistech, Micalis, UMR 1319 Jouy en Josas, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Leclerc
authors.affiliation: Institut National de la Recherche Agronomique, Micalis, UMR 1319 Jouy en Josas, France ; Agroparistech, Micalis, UMR 1319 Jouy en Josas, France.
authors.forename: Colin R
authors.initials: CR
authors.lastname: Tinsley
authors.affiliation: Institut National de la Recherche Agronomique, Micalis, UMR 1319 Jouy en Josas, France ; Agroparistech, Micalis, UMR 1319 Jouy en Josas, France.
authors.forename: Marie-Agnès
authors.initials: MA
authors.lastname: Petit
mesh_terms: D000818:Animals; D001435:Bacteriophages / Q000254:growth & development / Q000502:physiology*; D064806:Dysbiosis; D017753:Ecosystem; D006262:Health; D006706:Homeostasis; D006801:Humans; D064307:Microbiota
keywords: biological weapon; community shuffling; digestive tract; horizontal transfer; virome
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