title: The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee.
abstract: OBJECTIVE
  To assess the outcome of intra-articular platelet-rich plasma (PRP) injections into the knee in patients with early stages of osteoarthritis (OA) and to determine whether cyclical dosing would affect the end result.
  
  
  METHODS
  This is a prospective, randomized study in which 93 patients (119 knees) were followed up for a minimum of 2 years. Fifty knees were randomly selected prior to the first injection, to receive a second cycle at the completion of 1 year. A cycle consisted of three injections, each given at a monthly interval. The outcome was assessed using Knee Injury and Osteoarthritis Outcome Score (KOOS), Visual Analogue Scale (VAS), Tegner and Marx scoring systems, recorded prior to the first injection and then at 12, 18 and 24 months.
  
  
  RESULTS
  There was a significant improvement in all scores over time compared to the pre-treatment value (p < 0.001). At 12 months, both groups showed similar and significant improvement. At 18 months, except for KOOS (Symptoms) and Tegner score, all other parameters showed a significant difference between the two groups in favour of the patients who had received the second cycle (p < 0.001). At 2 years, the scores declined in both groups but remained above the pre-treatment value with no significant difference between the groups despite the patients with two cycles showing higher mean values for all the scores.
  
  
  CONCLUSIONS
  Intra-articular PRP injections into the knee for symptomatic early stages of OA are a valid treatment option. There is a significant reduction in pain and improvement in function after 12 months, which can be further improved at 18 months by annual repetition of the treatment. Although the beneficial effects are ill sustained at 2 years, the results are encouraging when compared to the pre-treatment function.
  
  
  METHODS
  II.
authors.affiliation: O.A.S.I. Bioresearch Foundation, Via Amadeo 24, 20133, Milan, Italy. gobbi@cartilagedoctor.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Gobbi
authors.affiliation: O.A.S.I. Bioresearch Foundation, Via Amadeo 24, 20133, Milan, Italy.
authors.forename: Dnyanesh
authors.initials: D
authors.lastname: Lad
authors.affiliation: O.A.S.I. Bioresearch Foundation, Via Amadeo 24, 20133, Milan, Italy.
authors.forename: Georgios
authors.initials: G
authors.lastname: Karnatzikos
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000628:therapy*; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D064232:Visual Analog Scale
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