title: Acute retinal necrosis associated with Epstein-Barr virus: immunohistopathologic confirmation.
abstract: OBJECTIVE
  Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation. We report the clinical history and histopathologic confirmation that EBV can cause ARN.
  
  
  METHODS
  Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology.
  
  
  CONCLUSIONS
  Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky.
authors.forename: Shlomit
authors.initials: S
authors.lastname: Schaal
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky.
authors.forename: Aleksandr
authors.initials: A
authors.lastname: Kagan
authors.affiliation: Laboratory of Immunology, Immunopathology Section, National Eye Institute, Bethesda, Maryland.
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Laboratory of Immunology, Immunopathology Section, National Eye Institute, Bethesda, Maryland.
authors.forename: Chi-Chao
authors.initials: CC
authors.lastname: Chan
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky.
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Kaplan
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D000998:Antiviral Agents / Q000627:therapeutic use; D036022:Capsid Proteins / Q000276:immunology; D004279:DNA, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000473:pathology* / Q000628:therapy / Q000821:virology; D019309:Epstein-Barr Virus Nuclear Antigens / Q000276:immunology; D015353:Eye Enucleation; D015828:Eye Infections, Viral / Q000473:pathology* / Q000628:therapy / Q000821:virology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008875:Middle Aged; D015882:Retinal Necrosis Syndrome, Acute / Q000473:pathology* / Q000628:therapy / Q000821:virology; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014822:Vitreous Body / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D000998:Antiviral Agents; D036022:Capsid Proteins; D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; C041788:Epstein-Barr viral capsid antigen; D005938:Glucocorticoids; D007074:Immunoglobulin G; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir
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