title: Low follicular fluid tyrosine concentration in infertile women with ovarian hyperstimulation syndrome.
abstract: The aim of this study was to compare the branched-chain amino acid (BCAA) and tyrosine concentration in the follicular fluid of infertile women with and without ovarian hyperstimulation syndrome (OHSS) in anin vitrofertilization program combined with controlled ovarian stimulation. Follicular fluid was aspirated during oocyte retrieval from 20 infertile patients who developed moderate-to-severe OHSS and 20 age- and body mass index-matched normoresponders. BCAA and tyrosine concentration were measured using enzymatic methods. The follicular fluid BCAA concentration was similar between the two groups (P=0.55), whereas tyrosine concentration was significantly lower in the OHSS compared to that in the normoresponder group (P=0.027) and the BCAA/tyrosine ratio was significantly higher in the OHSS compared to that in the normoresponder group (P=0.034). These results suggest an association between low follicular fluid tyrosine concentration and OHSS. Dopamine receptor agonists may be used as potential anti-OHSS medicines and tyrosine, as a dopamine precursor, may play a role against the development of OHSS.
authors.affiliation: IVF Center, Oak Clinic, Osaka 557-0045, Japan.
authors.forename: Namiko
authors.initials: N
authors.lastname: Amano
authors.affiliation: IVF Center, Oak Clinic, Osaka 557-0045, Japan.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Kitaya
authors.affiliation: IVF Center, Oak Clinic, Osaka 557-0045, Japan.
authors.forename: Sagiri
authors.initials: S
authors.lastname: Taguchi
authors.affiliation: IVF Center, Oak Clinic, Osaka 557-0045, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Funabiki
authors.affiliation: IVF Center, Oak Clinic, Osaka 557-0045, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tada
authors.affiliation: IVF Center, Oak Clinic, Osaka 557-0045, Japan.
authors.forename: Terumi
authors.initials: T
authors.lastname: Hayashi
authors.affiliation: IVF Center, Oak Clinic, Osaka 557-0045, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nakamura
keywords: dopamine agonist; follicular fluid; in vitro fertilization; ovarian hyperstimulation syndrome; tyrosine
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