title: Eco-immunology of fish invasions: the role of MHC variation.
abstract: The relationship between invaders and the pathogens encountered in their new environment can have a large effect on invasion success. Invaders can become free from their natural pathogens and reallocate costly immune resources to growth and reproduction, thereby increasing invasion success. Release from enemies and relaxation of selective pressures could render newly founded populations more variable at immune-related genes, such as the major histocompatibility complex (MHC), particularly when they have different origins. Using rainbow and brown trout, two of the world's most successful fish invaders, we tested the general hypothesis that invaders should display high intrapopulation immunogenetic diversity and interpopulation divergence, due to the interplay between genetic drift and successive waves of genetically divergent introductions. We analysed genetic diversity and signatures of selection at the MHC class II β immune-related locus. In both species, MHC diversity (allelic richness and heterozygosity) for southern hemisphere populations was similar to values reported for populations at their native range. However, MHC functional diversity was limited, and population immunogenetic structuring weaker than that observed using neutral markers. Depleted MHC functional diversity could reflect a decrease in immune response, immune-related assortative mating or selection for resistance to newly encountered parasites. Given that the role of MHC diversity in the survival of these populations remains unclear, depleted functional diversity of invasive salmonids could compromise their long-term persistence. A better understanding of the eco-immunology of invaders may help in managing and preventing the impact of biological invasions, a major cause of loss of biodiversity worldwide.
authors.affiliation: Department of Biosciences, Swansea University, Swansea, SA2 8PP, UK.
authors.forename: C
authors.initials: C
authors.lastname: Monzón-Argüello
authors.forename: C
authors.initials: C
authors.lastname: Garcia de Leaniz
authors.forename: G
authors.initials: G
authors.lastname: Gajardo
authors.forename: S
authors.initials: S
authors.lastname: Consuegra
mesh_terms: D000483:Alleles; D000818:Animals; D002677:Chile; D017753:Ecosystem; D019432:Falkland Islands; D005787:Gene Frequency; D040961:Genetic Drift; D014644:Genetic Variation; D000949:Histocompatibility Antigens Class II / Q000145:classification / Q000235:genetics* / Q000276:immunology; D058865:Introduced Species; D017686:Oncorhynchus mykiss / Q000235:genetics* / Q000276:immunology; D010802:Phylogeny; D058974:Phylogeography; D012641:Selection, Genetic
chemical_list: D000949:Histocompatibility Antigens Class II
references.citation: Bioinformatics. 2009 Jun 1;25(11):1451-2
references.pmid: 19346325
references.citation: Mol Ecol. 2005 Jul;14(8):2611-20
references.pmid: 15969739
references.citation: Theor Popul Biol. 1972 Mar;3(1):87-112
references.pmid: 4667078
references.citation: Genetics. 1992 Nov;132(3):861-4
references.pmid: 1468635
references.citation: Bioinformatics. 2010 Oct 1;26(19):2455-7
references.pmid: 20671151
references.citation: Mol Biol Evol. 2007 Aug;24(8):1586-91
references.pmid: 17483113
references.citation: J Evol Biol. 2003 May;16(3):363-77
references.pmid: 14635837
references.citation: Mol Ecol Resour. 2010 May;10(3):564-7
references.pmid: 21565059
references.citation: Crit Rev Immunol. 1997;17(2):179-224
references.pmid: 9094452
references.citation: Trends Ecol Evol. 2004 Oct;19(10):523-9
references.pmid: 16701317
references.citation: PLoS Genet. 2012;8(7):e1002764
references.pmid: 22807683
references.citation: Heredity (Edinb). 2007 Sep;99(3):265-77
references.pmid: 17519969
references.citation: J Evol Biol. 2006 Mar;19(2):558-69
references.pmid: 16599932
references.citation: Proc Biol Sci. 2001 Jun 22;268(1473):1279-85
references.pmid: 11410155
references.citation: Proc Biol Sci. 2006 May 7;273(1590):1111-6
references.pmid: 16600889
references.citation: Annu Rev Genet. 1998;32:415-35
references.pmid: 9928486
references.citation: Mol Ecol. 2006 Apr;15(4):923-37
references.pmid: 16599957
references.citation: Ecol Evol. 2013 Sep;3(10):3359-68
references.pmid: 24223274
references.citation: Mol Biol Evol. 2002 Jan;19(1):49-57
references.pmid: 11752189
references.citation: Immunogenetics. 2010 Aug;62(8):531-42
references.pmid: 20521040
references.citation: Genet Res. 1994 Aug;64(1):71-4
references.pmid: 7958833
references.citation: Am Nat. 1993 Jun;141(6):847-65
references.pmid: 19425992
references.citation: Science. 2001 Nov 23;294(5547):1655-6
references.pmid: 11721035
references.citation: Proc Biol Sci. 2008 Jun 22;275(1641):1397-403
references.pmid: 18364312
references.citation: Mol Ecol. 2008 Jan;17(1):20-9
references.pmid: 18173498
references.citation: Nature. 2003 Feb 6;421(6923):625-7
references.pmid: 12571594
references.citation: Trends Ecol Evol. 2006 Nov;21(11):645-51
references.pmid: 16859805
references.citation: Evolution. 2003 Aug;57(8):1707-22
references.pmid: 14503614
references.citation: Biol Lett. 2005 Dec 22;1(4):400-3
references.pmid: 17148217
references.citation: J Evol Biol. 2003 Mar;16(2):224-32
references.pmid: 14635861
references.citation: Nature. 1975 Jul 3;256(5512):50-2
references.pmid: 1079575
references.citation: Trends Ecol Evol. 2004 Oct;19(10):554-9
references.pmid: 16701321
references.citation: Science. 2010 May 28;328(5982):1164-8
references.pmid: 20430971
references.citation: Genet Res. 1996 Dec;68(3):259-60
references.pmid: 9062082
references.citation: Genetics. 1978 Feb;88(2):405-17
references.pmid: 17248803
references.citation: Nat Commun. 2012 Jan 10;3:621
references.pmid: 22233631
references.citation: Proc Biol Sci. 2004 Jan 22;271(1535):197-204
references.pmid: 15058398
references.citation: Evolution. 1989 Jan;43(1):223-225
references.pmid: 28568501
references.citation: Mol Biol Evol. 2013 May;30(5):1196-205
references.pmid: 23420840
references.citation: Evolution. 2006 Feb;60(2):383-9
references.pmid: 16610328
references.citation: Trends Ecol Evol. 1998 Oct 1;13(10):391-6
references.pmid: 21238358
references.citation: Evol Appl. 2011 Sep;4(5):660-71
references.pmid: 25568013
references.citation: Genet Res. 2003 Apr;81(2):115-21
references.pmid: 12872913
references.citation: Proc Biol Sci. 2012 Dec 22;279(1749):5004-13
references.pmid: 23075838
references.citation: Anim Behav. 1998 Aug;56(2):319-327
references.pmid: 9787022
references.citation: Genetics. 2000 Jun;155(2):945-59
references.pmid: 10835412
references.citation: Ecol Appl. 2012 Apr;22(3):828-42
references.pmid: 22645814
references.citation: Nature. 2003 Feb 6;421(6923):628-30
references.pmid: 12571595
references.citation: J Comput Aided Mol Des. 2005 Mar;19(3):203-12
references.pmid: 16059672
references.citation: Trends Ecol Evol. 2013 Jan;28(1):58-66
references.pmid: 22889499