title: Complexation of carbendazim with hydroxypropyl-β-cyclodextrin to improve solubility and fungicidal activity.
abstract: The effect of hydroxypropyl-β-cyclodextrin (HPβCD) on the improvement of the solubility and fungicidal activity of carbendazim (MBC) has been investigated. The inclusion complexation of HPβCD with MBC has been prepared and characterized by phase solubility diagram, fluorescence, (1)H NMR, ROESY and FT-IR spectra. The stoichiometric ratio and stability constant were determined by Job's plot and phase solubility studies, respectively. The inclusion complex MBC·HPβCD has exhibited different properties from MBC. The obtained inclusion complex was found to significantly improve the water solubility of MBC. In addition, the biological activity indicated that the complex displayed the better fungicidal activity than MBC. The present study provided useful information for a more rational application of MBC.
authors.affiliation: Institute of Agricultural Products Storage and Processing, Gansu Academy of Agricultural Sciences, Lanzhou 730070, PR China.
authors.forename: Xia
authors.initials: X
authors.lastname: Ge
authors.forename: Zheng
authors.initials: Z
authors.lastname: Huang
authors.forename: Shilong
authors.initials: S
authors.lastname: Tian
authors.forename: Yulong
authors.initials: Y
authors.lastname: Huang
authors.forename: Chaozhen
authors.initials: C
authors.lastname: Zeng
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology*; D002219:Carbamates / Q000737:chemistry* / Q000494:pharmacology*; D005659:Fungicides, Industrial / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D012995:Solubility; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D014242:Trichoderma / Q000187:drug effects / Q000254:growth & development; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D001562:Benzimidazoles; D002219:Carbamates; D005659:Fungicides, Industrial; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C006698:carbendazim