title: Baseline series fragrance markers fail to predict contact allergy.
abstract: BACKGROUND
  Negative patch test results with fragrance allergy markers in the European baseline series do not always predict a negative reaction to individual fragrance substances.
  
  
  OBJECTIVE
  To determine the frequencies of positive test reactions to the 26 fragrance substances for which labelling is mandatory in the EU, and how effectively reactions to fragrance markers in the baseline series predict positive reactions to the fragrance substances that are labelled.
  
  
  METHODS
  The records of 1951 eczema patients, routinely tested with the labelled fragrance substances and with an extended European baseline series in 2011 and 2012, were retrospectively reviewed.
  
  
  RESULTS
  Two hundred and eighty-one (14.4%) (71.2% females) reacted to one or more allergens from the labelled-fragrance substance series and/or a fragrance marker from the European baseline series. The allergens that were positive with the greatest frequencies were cinnamyl alcohol (48; 2.46%), Evernia furfuracea (44; 2.26%), and isoeugenol (40; 2.05%). Of the 203 patients who reacted to any of the 26 fragrances in the labelled-fragrance substance series, only 117 (57.6%) also reacted to a fragrance marker in the baseline series. One hundred and seven (52.7%) reacted to either fragrance mix I or fragrance mix II, 28 (13.8%) reacted to Myroxylon pereirae, and 13 (6.4%) reacted to hydroxyisohexyl 3-cyclohexene carboxaldehyde.
  
  
  CONCLUSIONS
  These findings confirm that the standard fragrance markers fail to identify patients with contact allergies to the 26 fragrances.
authors.affiliation: Friends Dermatology Centre, Kent and Canterbury Hospital, CT13NG Canterbury, UK.
authors.forename: Jack
authors.initials: J
authors.lastname: Mann
authors.forename: John P
authors.initials: JP
authors.lastname: McFadden
authors.forename: Jonathan M L
authors.initials: JM
authors.lastname: White
authors.forename: Ian R
authors.initials: IR
authors.lastname: White
authors.forename: Piu
authors.initials: P
authors.lastname: Banerjee
mesh_terms: D000485:Allergens / Q000008:administration & dosage / Q000276:immunology; D003429:Cross Reactions; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D010328:Patch Tests / Q000379:methods*; D010476:Perfume / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D000485:Allergens; D010476:Perfume
keywords: 26 labelled fragrances; allergic contact dermatitis; cross-reactions; fragrance series; fragrances; markers; screens