title: Tbr2 is required to generate a neural circuit mediating the pupillary light reflex.
abstract: There are ∼20 types of retinal ganglion cells (RGCs) in mice, each of which has distinct molecular, morphological, and physiological characteristics. Each RGC type sends axon projections to specific brain areas that execute light-dependent behaviors. Here, we show that the T-box transcription factor Tbr2 is required for the development of several RGC types that participate in non-image-forming circuits. These types are molecularly distinct, project to non-image-forming targets, and include intrinsically photosensitive RGCs. Tbr2 mutant mice have reduced retinal projections to non-image-forming nuclei and an attenuated pupillary light reflex. These data demonstrate that Tbr2 acts to execute RGC type choice and/or survival in a set of RGCs that mediates light-induced subconscious behaviors.
authors.affiliation: Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California 95064.
authors.forename: Neal T
authors.initials: NT
authors.lastname: Sweeney
authors.forename: Hannah
authors.initials: H
authors.lastname: Tierney
authors.forename: David A
authors.initials: DA
authors.lastname: Feldheim
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001369:Axons / Q000502:physiology*; D015820:Cadherins / Q000235:genetics; D064032:Calbindin 2 / Q000235:genetics / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D011680:Pupil / Q000502:physiology*; D050638:Receptors, Dopamine D4 / Q000235:genetics / Q000378:metabolism; D012018:Reflex / Q000235:genetics / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000502:physiology; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism*; D014795:Visual Pathways / Q000502:physiology*
chemical_list: D015820:Cadherins; C576511:Calb2 protein, mouse; D064032:Calbindin 2; C493600:Drd4 protein, mouse; C491198:Eomes protein, mouse; D020825:T-Box Domain Proteins; D050638:Receptors, Dopamine D4; D049452:Green Fluorescent Proteins
keywords: TBR2; axon projections; retina; visual circuit
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