title: Establishing regional specificity of neuroestrogen action.
abstract: The specificity of estrogen signaling in brain is defined at one level by the types and distributions of receptor molecules that are activated by estrogens. At another level, as our understanding of the neurobiology of the estrogen synthetic enzyme aromatase has grown, questions have emerged as to how neuroactive estrogens reach specific target receptors in functionally relevant concentrations. Here we explore the spatial specificity of neuroestrogen signaling with a focus on studies of songbirds to provide perspective on some as-yet unresolved questions. Studies conducted in both male and female songbirds have helped to clarify these interesting facets of neuroestrogen physiology.
authors.affiliation: Dept. of Integrative Biology and Physiology and the Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, CA, USA. Electronic address: schlinge@lifesci.ucla.edu.
authors.forename: Barney A
authors.initials: BA
authors.lastname: Schlinger
authors.affiliation: Neuroscience and Behavior Program, Molecular and Cellular Biology Program, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA, USA.
authors.forename: Luke
authors.initials: L
authors.lastname: Remage-Healey
authors.affiliation: Dept. of Integrative Biology and Physiology and the Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, CA, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Rensel
mesh_terms: D000818:Animals; D001141:Aromatase / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D008297:Male; D017551:Microdialysis; D009928:Organ Specificity; D020308:Songbirds / Q000502:physiology*
chemical_list: D004967:Estrogens; D004958:Estradiol; D001141:Aromatase
keywords: Aromatase; Estradiol; Neuroestrogen; Neurosteroid; Songbird
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