title: Calculation of LDL apoB.
abstract: OBJECTIVE
  This study tests the validity of the Hattori formula to calculate LDL apoB based on plasma lipids and total apoB.
  
  
  METHODS
  In 2178 patients in a tertiary care lipid clinic, LDL apoB calculated as suggested by Hattori et al. was compared to directly measured LDL apoB isolated by ultracentrifugation.
  
  
  RESULTS
  In subjects with plasma triglycerides ≥ 3.0 mmol/L, there was considerable discordance between calculated and measured LDL apoB. In all others, the relation between measured LDL apoB and calculated LDL apoB could be expressed as LDL apoB = 0.86 [total apoB - 0.9 TC (mg/dL) + 0.09 HDL-C (mg/dL) - 0.08 TG (mg/dL)] - 7.0 (r > 0.91; P < 0.0001).
  
  
  CONCLUSIONS
  Our results indicate that LDL apoB can be calculated with reasonable accuracy when triglycerides are <3.0 mmol/L. However, the calculation suggested by Hattori et al. should be corrected based on the regression demonstrated between calculated and measured LDL apoB in subjects with a plasma triglyceride <3.0 mmol/L.
authors.affiliation: Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Room H7.22, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada. Electronic address: allansniderman@hotmail.com.
authors.forename: Allan D
authors.initials: AD
authors.lastname: Sniderman
authors.affiliation: Lipid Research Center, Laval University Medical Center, 705, Boulevard Laurier, C-00102 Quebec City, Quebec G1V 4G2, Canada.
authors.forename: André J
authors.initials: AJ
authors.lastname: Tremblay
authors.affiliation: Department of Medicine, Division of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: De Graaf
authors.affiliation: Lipid Research Center, Laval University Medical Center, 705, Boulevard Laurier, C-00102 Quebec City, Quebec G1V 4G2, Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Couture
mesh_terms: D000293:Adolescent; D000328:Adult; D053299:Apolipoprotein B-100 / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012044:Regression Analysis; D015203:Reproducibility of Results; D062606:Tertiary Care Centers; D014280:Triglycerides / Q000097:blood; D014461:Ultracentrifugation; D055815:Young Adult
chemical_list: C569471:APOB protein, human; D053299:Apolipoprotein B-100; D015415:Biomarkers; D008076:Cholesterol, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides
keywords: Calculated LDL apoB; Total apoB; VLDL apoB