title: Baseline immunity to diphtheria and immunologic response after booster vaccination with reduced diphtheria and tetanus toxoid vaccine in Thai health care workers.
abstract: A prospective study to evaluate immune status against diphtheria and immunologic response after tetanus-diphtheria (Td) booster vaccination was conducted in 250 Thai health care workers (HCWs). A protective antibody was found in 89.2% of the HCWs (95% confidence interval [CI], 83.3%-91.5%) before receipt of the Td booster vaccination, compared with 97.2% (95% CI, 95.1%-99.3%) after receipt of the first dose of booster (P < .001). The mean antibody level against diphtheria increased from 0.39 IU/mL (95% CI, 0.35-0.44 IU/mL) before the Td booster vaccination to 1.20 IU/mL (95% CI, 1.12-1.29 IU/mL) after the vaccination (P < .001). Td booster vaccination should be considered for Thai HCWs to maintain immunity against diphtheria, which still circulates in Thailand.
authors.affiliation: Bamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand. Electronic address: srsw135@yahoo.com.
authors.forename: Surasak
authors.initials: S
authors.lastname: Wiboonchutikul
authors.affiliation: Bamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: Weerawat
authors.initials: W
authors.lastname: Manosuthi
authors.affiliation: Bamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: Chariya
authors.initials: C
authors.lastname: Sangsajja
authors.affiliation: Bamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: Varaporn
authors.initials: V
authors.lastname: Thientong
authors.affiliation: Bamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: Sirirat
authors.initials: S
authors.lastname: Likanonsakul
authors.affiliation: Bamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: Somkid
authors.initials: S
authors.lastname: Srisopha
authors.affiliation: Bamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: Patamavadee
authors.initials: P
authors.lastname: Termvises
authors.affiliation: Bamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: Jitlada
authors.initials: J
authors.lastname: Rujitip
authors.affiliation: Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Suda
authors.initials: S
authors.lastname: Loiusirirotchanakul
authors.affiliation: Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Pilaipan
authors.initials: P
authors.lastname: Puthavathana
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D004165:Diphtheria / Q000276:immunology* / Q000517:prevention & control*; D022422:Diphtheria-Tetanus Vaccine / Q000008:administration & dosage / Q000276:immunology*; D005260:Female; D006282:Health Personnel; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013785:Thailand; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D022422:Diphtheria-Tetanus Vaccine
keywords: Booster immunization; Diphtheria antibody; Health care personnel; Serologic response; Thailand