title: 3D graphene foams decorated by CuO nanoflowers for ultrasensitive ascorbic acid detection.
abstract: When the in vitro research works of biosensing begin to mimic in vivo conditions, some certain three-dimensional (3D) structures of biosensors are needed to accommodate biomolecules, bacteria or even cells to resemble the in vivo 3D environment. To meet this end, a novel method of synthesizing CuO nanoflowers on the 3D graphene foam (GF) was first demonstrated. The 3DGF/CuO nanoflowers composite was used as a monolithic free-standing 3D biosensor for electrochemical detection of ascorbic acid (AA). The 3D conductive structure of the GF is favorable for current collection, mass transport and loading bioactive chemicals. And CuO nanoflowers further increase the active surface area and catalyze the redox of AA. Thus, all these features endows 3DGF/CuO composite with outstanding biosensing properties such as an ultrahigh sensitivity of 2.06 mA mM(-1) cm(-2) to AA at 3 s response time.
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Minggang
authors.initials: M
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Cai
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China; Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310058, China.
authors.forename: Zhizhen
authors.initials: Z
authors.lastname: Ye
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China; Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310058, China. Electronic address: huangjy@zju.edu.cn.
authors.forename: Jingyun
authors.initials: J
authors.lastname: Huang
mesh_terms: D001205:Ascorbic Acid / Q000032:analysis*; D015374:Biosensing Techniques / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D055664:Electrochemical Techniques; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D057230:Limit of Detection; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D006108:Graphite; D003300:Copper; D001205:Ascorbic Acid; C030973:cupric oxide
keywords: Ascorbic acid; Biosensor; Copper oxide; Free-standing; Graphene foam; Three dimensions