title: [Mechanisms of development and clinical endoscopic characteristics of hp-negative gastropathy in patients with chronic heart failure].
abstract: Hp-negative gastropathies in chronic heart failure (CHF) are characterized with polyethiologic polymorphic changes of gastric mucosa (GM). At the same time the mechanisms of their development and peculiarities of clinical-endoscopic and morphological manifestations are understudied. The linkages of clinical and morphological changes of gastric mucosa with various factors, and, above all, the factors involved in the development and progression of heart failure, are needed to be studied fundamentally. Some of these factors are oxidative stress and lipid peroxidation, the enzyme activity of the antioxidant defense, immuno-inflammatory and vasoactive endothelial factors. The dependences between the mechanisms of development of Hp-negative gastropathies and CHF are understudied. Possible dependences between mechanisms of development of Hp-negative gastropathies and pathogenesis of main disease (hypertension), complicated by heart failure, are understudied also. It was revealed that the development of gastropathy in patients with hypertension of 2 degree and CHF was associated with depression disorders of lipid metabolism, activation of lipid peroxidation and decreased activity of enzymes of antioxidant protection. The predictors of macroscopic inflammatory changes of gastric mucosa in hypertensive patients with CHF and hp- negative gastropathies are atherogenic ratio, blood levels of diene conjugates, malondialdehyde and catalase.
authors.affiliation: Kharkiv National Medical University; City Clinical Hospital № 27, Kharkiv, Ukraine.
authors.forename: O
authors.initials: O
authors.lastname: Boiko
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001284:Atrophy; D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D002908:Chronic Disease; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D005773:Gastroscopy; D006333:Heart Failure / Q000150:complications* / Q000473:pathology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D006973:Hypertension / Q000150:complications; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D013272:Stomach Diseases / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D002784:Cholesterol; D002374:Catalase; D013482:Superoxide Dismutase