title: Protective effects of the polyphenol sesamin on allergen-induced T(H)2 responses and airway inflammation in mice.
abstract: Allergic asthma is a lifelong airway condition that affects people of all ages. In recent decades, asthma prevalence continues to increase globally, with an estimated number of 250,000 annual deaths attributed to the disease. Although inhaled corticosteroids and β-adrenergic receptor agonists are the primary therapeutic avenues that effectively reduce asthma symptoms, profound side effects may occur in patients with long-term treatments. Therefore, development of new therapeutic strategies is needed as alternative or supplement to current asthma treatments. Sesamin is a natural polyphenolic compound with strong anti-oxidative effects. Several studies have reported that sesamin is effective in preventing hypertension, thrombotic tendency, and neuroinflammation. However, it is still unknown whether sesamin can reduce asthma-induced allergic inflammation and airway hyperresponsiveness (AHR). Our study has revealed that sesamin exhibited significant anti-inflammatory effects in ovalbumin (OVA)-induced murine asthma model. We found that treatments with sesamin after OVA sensitization and challenge significantly decreased expression levels of interleukin-4 (IL-4), IL-5, IL-13, and serum IgE. The numbers of total inflammatory cells and eosinophils in BALF were also reduced in the sesamin-treated animals. Histological results demonstrated that sesamin attenuated OVA-induced eosinophil infiltration, airway goblet cell hyperplasia, mucus occlusion, and MUC5AC expression in the lung tissue. Mice administered with sesamin showed limited increases in AHR compared with mice receiving vehicle after OVA challenge. OVA increased phosphorylation levels of IκB-α and nuclear expression levels of NF-κB, both of which were reversed by sesamin treatments. These data indicate that sesamin is effective in treating allergic asthma responses induced by OVA in mice.
authors.affiliation: Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Ching-Huei
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Shen
authors.affiliation: Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Clinical Medical Science, China Medicine University, Taichung, Taiwan.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhou
authors.affiliation: Department of Microbiology and Immunology, School of Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Lee
authors.affiliation: Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Shung-Te
authors.initials: ST
authors.lastname: Kao
authors.affiliation: Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Clinical Medical Science, China Medicine University, Taichung, Taiwan.
authors.forename: Dong Chuan
authors.initials: DC
authors.lastname: Wu
mesh_terms: D021581:Active Transport, Cell Nucleus; D000485:Allergens / Q000276:immunology; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid; D016207:Cytokines / Q000378:metabolism; D004149:Dioxoles / Q000494:pharmacology* / Q000627:therapeutic use; D004804:Eosinophils / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood; D017705:Lignans / Q000494:pharmacology* / Q000627:therapeutic use; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008297:Male; D008807:Mice, Inbred BALB C; D009093:Mucus / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D018418:Th2 Cells / Q000187:drug effects* / Q000276:immunology
chemical_list: D000485:Allergens; D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D016207:Cytokines; D004149:Dioxoles; D017705:Lignans; D016328:NF-kappa B; D007073:Immunoglobulin E; C054125:sesamin
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