title: Role of interleukin-6 in regulation of immune responses to remodeling after myocardial infarction.
abstract: Myocardial remodeling following myocardial infarction (MI) is emerging as key causes of chronic infarct mortality. Interleukin-6 is a classic pro-inflammatory cytokine needed to mount an effective immune response. It seems that interleukin-6 acts as an important role in the dynamic and superbly orchestrated process of innate immunity after MI. Interleukin-6 timely suppresses of innate immune signals to prevent the catastrophic consequences of uncontrolled inflammation on cardiac geometry and function, and thus tunes myocardial remodeling. A comprehensive understanding of biological processes of interleukin-6 in innate immunity leading to inflammatory response and disease-related ventricular remodeling is helpful to find the solution of chronic heart failure. To accomplish this, we reviewed the articles of interleukin-6 regard to inflammation, innate immunity, and cardiac remodeling. This review focuses on the role of interleukin-6 that dominates cell-mediated immunity, especially on neutrophils, monocytes, macrophages, and fibroblasts. In addition, we will also briefly discuss other inflammatory cytokines involved in this process within the paper.
authors.affiliation: Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Province, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Huang
authors.forename: Du
authors.initials: D
authors.lastname: Yang
authors.forename: Meixiang
authors.initials: M
authors.lastname: Xiang
authors.forename: Jianan
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D005347:Fibroblasts / Q000276:immunology; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D009000:Monocytes / Q000276:immunology; D009203:Myocardial Infarction / Q000276:immunology / Q000503:physiopathology*; D009206:Myocardium / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D015850:Interleukin-6
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