title: Association of hematological parameters with insulin resistance in type 1 diabetes.
abstract: OBJECTIVE
  Previous studies reported independent associations of hematological parameters with insulin resistance. The aim of this study was to explore the associations of hematological parameters, including red blood cell count (RBC), hemoglobin (Hgb), white blood cell count (WBC), and platelets with insulin resistance in type 1 diabetes.
  
  
  METHODS
  Study included 353 patients with type 1 diabetes. None showed signs of acute or chronic inflammatory, renal and cardiovascular diseases. Insulin sensitivity was measured with estimated glucose disposal rate (eGDR) calculated with the equation: eGDR=24.31-(12.22xWHR)-(3.29xAHT)-(0.57xHbA1c). The units were mg.kg-1min-1; WHR=waist to hip ratio; AHT=hypertension.
  
  
  RESULTS
  RBC, Hgb, and WBC significantly correlated with insulin resistance measured by eGDR (r=-0.12, -0.21, and -0.14, respectively, all P≤0.01), and its components disorders, most notably WHR (r=0.38, 0.44, and 0.16, respectively, all P≤0.001). In a multiple logistic regression analysis after adjustment for age, sex, duration of diabetes and BMI, the presence of insulin resistance was independently associated with WBC count (odds ratio=1.28, P<0.01). The risk of insulin resistance increases by a factor of 4.41 for those in the 4th quartile of WBC, compared to those in 1st quartile.
  
  
  CONCLUSIONS
  The significant independent association of WBC with the presence of insulin resistance suggests a role of subclinical inflammation in its pathogenesis.
authors.affiliation: Vuk Vrhovac Clinic for Diabetes Endocrinology and Metabolic Diseases University Hospital Merkur, School of Medicine University of Zagreb, Croatia - tbulum@idb.hr.
authors.forename: T
authors.initials: T
authors.lastname: Bulum
authors.forename: B
authors.initials: B
authors.lastname: Kolarić
authors.forename: L
authors.initials: L
authors.lastname: Duvnjak
authors.forename: R
authors.initials: R
authors.lastname: Vrhovac
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D004906:Erythrocyte Count; D005260:Female; D006454:Hemoglobins; D006801:Humans; D007249:Inflammation / Q000097:blood; D007333:Insulin Resistance; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers; D006454:Hemoglobins