title: Snapshot of antidepressants at work: the structure of neurotransmitter transporter proteins.
abstract: In the sweet spot: Cocrystal structures of engineered neurotransmitter transporters reveal the binding mode of commonly prescribed antidepressants, providing a basis for a rational drug design for this class of proteins. The picture shows the structure of the dopamine transporter of Drosophila melanogaster in complex with the antidepressant nortriptyline.
authors.affiliation: AG Chemical Genomics, Max Planck Institute of Psychiatry, Kraepelinstrasse 2, Munich (Germany) http://www.mpipsykl.mpg.de/en/research/groups/hausch/index.html.
authors.forename: Serena
authors.initials: S
authors.lastname: Cuboni
authors.forename: Felix
authors.initials: F
authors.lastname: Hausch
mesh_terms: D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001679:Biogenic Amines / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000737:chemistry*; D004331:Drosophila melanogaster / Q000737:chemistry*; D006801:Humans; D009661:Nortriptyline / Q000494:pharmacology*; D050480:Plasma Membrane Neurotransmitter Transport Proteins; D011993:Recombinant Fusion Proteins / Q000737:chemistry*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000737:chemistry* / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D001679:Biogenic Amines; D050483:Dopamine Plasma Membrane Transport Proteins; D009661:Nortriptyline; D050480:Plasma Membrane Neurotransmitter Transport Proteins; D011993:Recombinant Fusion Proteins; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors
keywords: antidepressants; membrane proteins; neurotransmitters; structure eludication; transporters