title: Adolescent MDMA exposure diminishes the physiological and neurotoxic consequences of an MDMA binge in female rats.
abstract: Intermittent MDMA pretreatment blocked the reductions in serotonin transporter (SERT) binding induced by an MDMA binge in a prior study in adolescent male rats. The objective of this investigation was to determine if the physiological, behavioral, and neurochemical responses to MDMA are sexually dimorphic. Female Sprague-Dawley rats received MDMA (10 mg/kg × 2) or Saline on every fifth day from postnatal day (PD) 35-60 and an MDMA binge (5 mg/kg × 4) on PD 67. The MDMA binge induced a pronounced temperature dysregulation in MDMA-naïve, but not MDMA-pretreated, groups. Similarly, MDMA-pretreated animals were resistant to the binge-induced SERT reductions, especially in the hippocampus. Motor activity at PD 68 was not reduced by the binge, unlike the responses found in males. These results show that female rats differ from males in their responses to an MDMA binge but are similar with respect to preconditioning from prior MDMA exposure.
authors.affiliation: Neuroscience & Behavior Program, University of Massachusetts, Amherst, MA, 01003. piperbj@husson.edu, psy391@gmail.com.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Piper
authors.forename: Christina S
authors.initials: CS
authors.lastname: Henderson
authors.forename: Jerrold S
authors.initials: JS
authors.lastname: Meyer
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018490:Serotonin Agents / Q000008:administration & dosage*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D012737:Sex Factors
chemical_list: D018490:Serotonin Agents; D050486:Serotonin Plasma Membrane Transport Proteins; D018817:N-Methyl-3,4-methylenedioxyamphetamine
keywords: activity; ecstasy; hangover; hyperthermia; hypothermia; preconditioning; rat; serotonin transporter; sex; temperature; weight