title: Cytomegalovirus enteritis in immunocompetent subjects: a case report and review of the literature.
abstract: Cytomegalovirus (CMV) enteritis (or colitis) is generally diagnosed in immunocompromised patients in association with human immunodeficiency virus infection as well as in recipients of solid organ or hematopoietic stem cell transplant. CMV enteritis has been reported only sporadically in immunocompetent individuals. We encountered a 76-year-old woman who developed CMV enteritis without any previously identified immunocompromised states. An extensive literature review of 33 cases of CMV enteritis or colitis diagnosed in immunocompetent individuals, including the present case, revealed that the median age of the patients was 68, the accompanying symptoms were diarrhea (76%), abdominal pain (52%), and hematochezia or melena (27%), and that the outcome was generally favorable, including resolution without any treatment in 24% of the patients. CMV enteritis should be recognized more widely as a disease entity not only in immunocompromised patients but also in immunocompetent individuals, especially in elderly populations.
authors.affiliation: Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan; Department of Internal Medicine, Keiyu Hospital, Kanagawa, Japan.
authors.forename: Daiki
authors.initials: D
authors.lastname: Karigane
authors.affiliation: Department of Internal Medicine, Keiyu Hospital, Kanagawa, Japan.
authors.forename: Saho
authors.initials: S
authors.lastname: Takaya
authors.affiliation: Department of Internal Medicine, Keiyu Hospital, Kanagawa, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Seki
authors.affiliation: Department of Internal Medicine, Keiyu Hospital, Kanagawa, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Mastumoto
authors.affiliation: Department of Internal Medicine, Keiyu Hospital, Kanagawa, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Onose
authors.affiliation: Department of Internal Medicine, Keiyu Hospital, Kanagawa, Japan.
authors.forename: Arifumi
authors.initials: A
authors.lastname: Kosakai
authors.affiliation: Department of Pediatrics, Keiyu Hospital, Kanagawa, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Sugaya
authors.affiliation: Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. Electronic address: tmori@a3.keio.jp.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Mori
mesh_terms: D000368:Aged; D003586:Cytomegalovirus Infections / Q000209:etiology*; D004751:Enteritis / Q000209:etiology*; D005260:Female; D006801:Humans
keywords: Colitis; Cytomegalovirus; Enteritis; Ganciclovir; Immunocompetent individuals