title: Complete Genome Sequences of Eight Helicobacter pylori Strains with Different Virulence Factor Genotypes and Methylation Profiles, Isolated from Patients with Diverse Gastrointestinal Diseases on Okinawa Island, Japan, Determined Using PacBio Single-Molecule Real-Time Technology.
abstract: We report the complete genome sequences of eight Helicobacter pylori strains isolated from patients with gastrointestinal diseases in Okinawa, Japan. Whole-genome sequencing and DNA methylation detection were performed using the PacBio platform. De novo assembly determined a single, complete contig for each strain. Furthermore, methylation analysis identified virulence factor genotype-dependent motifs.
authors.affiliation: Okinawa Institute of Advanced Sciences, Uruma, Japan.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Satou
authors.forename: Akino
authors.initials: A
authors.lastname: Shiroma
authors.forename: Kuniko
authors.initials: K
authors.lastname: Teruya
authors.forename: Makiko
authors.initials: M
authors.lastname: Shimoji
authors.forename: Kazuma
authors.initials: K
authors.lastname: Nakano
authors.forename: Ayaka
authors.initials: A
authors.lastname: Juan
authors.forename: Hinako
authors.initials: H
authors.lastname: Tamotsu
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Terabayashi
authors.forename: Misako
authors.initials: M
authors.lastname: Aoyama
authors.forename: Morimi
authors.initials: M
authors.lastname: Teruya
authors.forename: Rumiko
authors.initials: R
authors.lastname: Suzuki
authors.forename: Miyuki
authors.initials: M
authors.lastname: Matsuda
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sekine
authors.forename: Nagisa
authors.initials: N
authors.lastname: Kinjo
authors.forename: Fukunori
authors.initials: F
authors.lastname: Kinjo
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamaoka
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirano
references.citation: J Clin Microbiol. 2012 Mar;50(3):876-83
references.pmid: 22189111
references.citation: OMICS. 2008 Jun;12(2):137-41
references.pmid: 18416670
references.citation: BMC Bioinformatics. 2010 Dec 10;11:595
references.pmid: 21143983
references.citation: Gut. 1996 Dec;39(6):800-6
references.pmid: 9038660
references.citation: Aliment Pharmacol Ther. 2004 Jul;20 Suppl 1:1-6
references.pmid: 15298598
references.citation: Nature. 1997 Aug 7;388(6642):539-47
references.pmid: 9252185
references.citation: Nat Rev Gastroenterol Hepatol. 2010 Nov;7(11):629-41
references.pmid: 20938460
references.citation: N Engl J Med. 2010 Apr 29;362(17):1597-604
references.pmid: 20427808
references.citation: Gastroenterol Res Pract. 2012;2012:371503
references.pmid: 22829807
references.citation: Nat Methods. 2010 Jun;7(6):461-5
references.pmid: 20453866
references.citation: Nat Methods. 2013 Jun;10(6):563-9
references.pmid: 23644548
references.citation: Science. 2009 Jan 2;323(5910):133-8
references.pmid: 19023044
references.citation: PLoS One. 2013 Jul 23;8(7):e68824
references.pmid: 23894349
references.citation: Genome Biol. 2013;14(9):R101
references.pmid: 24034426
references.citation: Science. 1999 May 21;284(5418):1328-33
references.pmid: 10334982
references.citation: PLoS One. 2013 Jun 28;8(6):e67539
references.pmid: 23840736