title: Serum adiponectin and leptin levels in psoriatic patients according to topical treatment.
abstract: OBJECTIVE
  Psoriasis has been considered as a systemic disease associated with obesity, cardiovascular diseases and metabolic syndrome. Adipokines have influence on many metabolic processes. Aim of this study was to evaluate the effect of conventional topical treatment on serum adiponectin and leptin levels in patients with psoriasis.
  
  
  METHODS
  Forty-nine patients with relapse of plaque-type psoriasis and 16 healthy controls were examined. Blood samples were collected before therapy and after 14 days of application. Serum adiponectin and leptin concentrations were examined by enzyme-linked immunosorbent assay for correlations with effectiveness of topical treatment.
  
  
  RESULTS
  Adiponectin and leptin serum levels were significantly decreased in psoriatic patients in comparison to the controls. As a result of the topical treatment, serum adiponectin level did not significantly change. Serum leptin level increased significantly, still remaining lower than in the controls.
  
  
  CONCLUSIONS
  Leptin might be a useful marker in assessing the efficacy of the treatment for psoriasis.
authors.affiliation: Department of Dermatology and Venereology and.
authors.forename: A
authors.initials: A
authors.lastname: Baran
authors.forename: I
authors.initials: I
authors.lastname: Flisiak
authors.forename: J
authors.initials: J
authors.lastname: Jaroszewicz
authors.forename: M
authors.initials: M
authors.lastname: Świderska
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin
keywords: Adipokines; adiponectin; leptin; psoriasis; psoriasis therapy