title: Chronic wasting disease agents in nonhuman primates.
abstract: Chronic wasting disease is a prion disease of cervids. Assessment of its zoonotic potential is critical. To evaluate primate susceptibility, we tested monkeys from 2 genera. We found that 100% of intracerebrally inoculated and 92% of orally inoculated squirrel monkeys were susceptible, but cynomolgus macaques were not, suggesting possible low risk for humans.
authors.forename: Brent
authors.initials: B
authors.lastname: Race
authors.forename: Kimberly D
authors.initials: KD
authors.lastname: Meade-White
authors.forename: Katie
authors.initials: K
authors.lastname: Phillips
authors.forename: James
authors.initials: J
authors.lastname: Striebel
authors.forename: Richard
authors.initials: R
authors.lastname: Race
authors.forename: Bruce
authors.initials: B
authors.lastname: Chesebro
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D004198:Disease Susceptibility; D005838:Genotype; D008251:Macaca; D008992:Monkey Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology*; D011323:Primates; D011328:Prions / Q000235:genetics / Q000378:metabolism; D012453:Saimiri; D034081:Wasting Disease, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology*
chemical_list: D011328:Prions
keywords: Chronic wasting disease; cynomolgus macaque; non-human primate; prion; species barrier; squirrel monkey; transmissible spongiform encephalopathy; transmission
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