title: Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.
abstract: Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.
authors.affiliation: Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology, Zürich, Switzerland.
authors.forename: Katharina
authors.initials: K
authors.lastname: Gapp
authors.affiliation: Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology, Zürich, Switzerland.
authors.forename: Ali
authors.initials: A
authors.lastname: Jawaid
authors.affiliation: Gurdon Institute, Cambridge, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Sarkies
authors.affiliation: Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology, Zürich, Switzerland.
authors.forename: Johannes
authors.initials: J
authors.lastname: Bohacek
authors.affiliation: Institute of Laboratory Animal Science, University of Zürich, Zürich, Switzerland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Pelczar
authors.affiliation: 1] FASTERIS SA, Plan-les-Ouates, Switzerland. [2].
authors.forename: Julien
authors.initials: J
authors.lastname: Prados
authors.affiliation: FASTERIS SA, Plan-les-Ouates, Switzerland.
authors.forename: Laurent
authors.initials: L
authors.lastname: Farinelli
authors.affiliation: Gurdon Institute, Cambridge, UK.
authors.forename: Eric
authors.initials: E
authors.lastname: Miska
authors.affiliation: Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology, Zürich, Switzerland.
authors.forename: Isabelle M
authors.initials: IM
authors.lastname: Mansuy
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D045744:Cell Line, Tumor; D003623:Dark Adaptation / Q000502:physiology; D004195:Disease Models, Animal; D002149:Energy Intake / Q000187:drug effects / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D008297:Male; D008426:Maternal Deprivation; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism; D034741:RNA, Small Interfering / Q000494:pharmacology; D058727:RNA, Small Untranslated / Q000008:administration & dosage; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013094:Spermatozoa; D013315:Stress, Psychological / Q000097:blood / Q000209:etiology* / Q000628:therapy*
chemical_list: D035683:MicroRNAs; D034741:RNA, Small Interfering; D058727:RNA, Small Untranslated
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