title: A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy.
abstract: A zinc(II) phthalocyanine substituted with a 2,4-dinitrobenzenesulfonate group has been prepared. Its fluorescence emission and reactive oxygen species generation can be greatly enhanced by glutathione in phosphate-buffered saline and inside MCF-7 cells. This compound thus functions as a highly efficient molecular-based activatable photosensitizer.
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong (P. R. China), Fax: (+852) 2603 5057.
authors.forename: Hui
authors.initials: H
authors.lastname: He
authors.forename: Pui-Chi
authors.initials: PC
authors.lastname: Lo
authors.forename: Dennis K P
authors.initials: DK
authors.lastname: Ng
mesh_terms: D005978:Glutathione / Q000737:chemistry*; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D061986:MCF-7 Cells; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*
chemical_list: D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; D005978:Glutathione; C013647:phthalocyanine
keywords: glutathione; photodynamic therapy; photosensitizers; phthalocyanines; singlet oxygen