title: A novel short-term plasticity of intrinsic excitability in the hippocampal CA1 pyramidal cells.
abstract: Changes in neuronal activity often trigger compensatory mechanisms aimed at regulating network activity homeostatically. Here we have identified and characterized a novel form of compensatory short-term plasticity of membrane excitability, which develops early after the eye-opening period in rats (P16-19 days) but not before that developmental stage (P9-12 days old). Holding the membrane potential of CA1 neurons right below the firing threshold from 15 s to several minutes induced a potentiation of the repolarizing phase of the action potentials that contributed to a decrease in the firing rate of CA1 pyramidal neurons in vitro. Furthermore, the mechanism for inducing this plasticity required the action of intracellular Ca(2+) entering through T-type Ca(2+) channels. This increase in Ca(2+) subsequently activated the Ca(2+) sensor K(+) channel interacting protein 3, which led to the increase of an A-type K(+) current. These results suggest that Ca(2+) modulation of somatic A-current represents a new form of homeostatic regulation that provides CA1 pyramidal neurons with the ability to preserve their firing abilities in response to membrane potential variations on a scale from tens of seconds to several minutes.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, 28040, Madrid, Spain colino@ucm.es.
authors.forename: A
authors.initials: A
authors.lastname: Sánchez-Aguilera
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, 28040, Madrid, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Sánchez-Alonso
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, 28040, Madrid, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Vicente-Torres
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, 28040, Madrid, Spain colino@ucm.es.
authors.forename: A
authors.initials: A
authors.lastname: Colino
mesh_terms: D000200:Action Potentials; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D020747:Calcium Channels, T-Type / Q000378:metabolism; D002478:Cells, Cultured; D005260:Female; D051605:Kv Channel-Interacting Proteins / Q000378:metabolism; D008297:Male; D009473:Neuronal Plasticity; D024642:Potassium Channels, Voltage-Gated / Q000378:metabolism; D017966:Pyramidal Cells / Q000378:metabolism / Q000502:physiology*; D051381:Rats
chemical_list: D020747:Calcium Channels, T-Type; D051605:Kv Channel-Interacting Proteins; D024642:Potassium Channels, Voltage-Gated; D002118:Calcium
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