title: [Association between AXIN2 polymorphism and oligodontia].
abstract: OBJECTIVE
  To explore the association between AXIN2 polymorphism and oligodontia in Chinese population.
  
  
  METHODS
  We employed 97 individuals diagnosed with sporadic non-syndromic oligodontia and 200 healthy control subjects. Their DNA was obtained from the whole blood or buccul swap samples and the genotyping was performed by polymerase chain reaction (PCR).
  
  
  RESULTS
  Significant differences were observed in the allele and genotype frequencies of rs145353986 of AXIN2. Distributions of genotypes GG, GC and CC of rs145353986 polymorphism were significantly different between the case group and the control group (P = 0.011) and C allelic frequency was higher in the case group (P=0.002).
  
  
  CONCLUSIONS
  These data demonstrate an association between rs145353986 of AXIN2 and non-syndromic oligodondia in the Chinese population. Furthermore, AXIN2 can be regarded as a marker gene for the risk of tooth agenesis.
authors.affiliation: Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Singwai
authors.initials: S
authors.lastname: Wong
authors.affiliation: Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Hao-chen
authors.initials: HC
authors.lastname: Liu
authors.affiliation: Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Han
authors.affiliation: Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Hai-lan
authors.initials: HL
authors.lastname: Feng
mesh_terms: D000483:Alleles; D000848:Anodontia / Q000235:genetics*; D044466:Asian People; D060466:Axin Protein / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: C491761:AXIN2 protein, human; D060466:Axin Protein