title: Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance.
abstract: Triglycerides in adipose tissue are rapidly mobilized during times of energy needs via lipolysis, a catabolic process that plays important role in whole body triglyceride turnover. Lipolysis is regulated through cell surface receptors via neurotransmitters, hormones, and paracrine factors that activate various intracellular pathways. These pathways converge on the lipid droplet, the site of action of lipases and cofactors. Fat cell lipolysis is also involved in the pathogenesis of metabolic disorders, and recent human studies have underscored its role in disease states such as cancer cachexia and obesity-induced insulin resistance. We highlight here topics and findings with physiological and clinical relevance, namely lipid turnover in human fat cells and the role of lipolysis in cancer cachexia and obesity-induced insulin resistance.
authors.affiliation: Karolinska Institutet, Department of Medicine at Karolinska University Hospital, 141 86 Stockholm, Sweden. Electronic address: peter.arner@ki.se.
authors.forename: Peter
authors.initials: P
authors.lastname: Arner
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Unité Mixte de Recherche (UMR) 1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, 31432 Toulouse, France; University of Toulouse, UMR 1048, Paul Sabatier University, 31432 Toulouse, France; Toulouse University Hospitals, Department of Clinical Biochemistry, 31059 Toulouse, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Langin
mesh_terms: D002100:Cachexia / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism / Q000502:physiology; D008066:Lipolysis / Q000502:physiology*; D009369:Neoplasms / Q000150:complications / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*
keywords: cancer cachexia; insulin resistance; lipolysis; obesity; triglyceride turnover