title: Design of tetraplex specific ligands: cyclic naphthalene diimide.
abstract: Cyclic naphthalene diimide 1 bound to hybrid-type tetraplex DNA from 5'-AGGG(TTAGGG)3-3' (K = 8.6 × 10(6) M(-1)) with 260-fold greater affinity than binding to a double stranded oligonucleotide consisting of 5'-GGG AGG TTT CGC-3' and 3'-CCC TCC AAA GCG-5' (nK = 3.3 × 10(4) M(-1)) with 0.5 μM of IC50 for telomerase activity.
authors.affiliation: Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan. shige@che.kyutech.ac.jp.
authors.forename: Yugo
authors.initials: Y
authors.lastname: Esaki
authors.forename: Md Monirul
authors.initials: MM
authors.lastname: Islam
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujii
authors.forename: Shinobu
authors.initials: S
authors.lastname: Sato
authors.forename: Shigeori
authors.initials: S
authors.lastname: Takenaka
mesh_terms: D002942:Circular Dichroism; D054856:G-Quadruplexes / Q000187:drug effects*; D007094:Imides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009690:Nucleic Acid Conformation; D011189:Potassium Chloride / Q000737:chemistry; D012965:Sodium Chloride / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: D007094:Imides; D009281:Naphthalenes; D012965:Sodium Chloride; D011189:Potassium Chloride; D019098:Telomerase