title: The use of aprepitant in a case of refractory nausea and vomiting.
abstract: BACKGROUND
  This case report describes a patient whose refractory nausea and vomiting significantly improved with the use of aprepitant, a neurokinin receptor antagonist currently only licensed for short-term use in chemotherapy-induced nausea and vomiting.
  
  
  METHODS
  A patient with breast cancer and meningeal metastases had an 18-month history of nausea and vomiting refractory to a number of antiemetics commonly used in palliative care. The nausea and vomiting resolved after receiving two doses of the drug aprepitant.
  Maintenance antiemetic treatment with aprepitant was continued over a 5-month period with no recurrence of nausea and vomiting, and no observed side effects.
  
  
  CONCLUSIONS
  Aprepitant has a potential role as an antiemetic for refractory symptoms within the palliative-care setting.
authors.affiliation: St Benedict's Hospice, Sunderland, UK.
authors.forename: Lucy
authors.initials: L
authors.lastname: Lowery
authors.affiliation: St Benedict's Hospice, Sunderland, UK.
authors.forename: Inga
authors.initials: I
authors.lastname: Andrew
authors.affiliation: St Benedict's Hospice, Sunderland, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Gill
authors.affiliation: St Benedict's Hospice, Sunderland, UK mark.lee@stft.nhs.uk.
authors.forename: Mark
authors.initials: M
authors.lastname: Lee
keywords: Aprepitant; nausea; neurokinin receptor antagonist; refractory; vomiting