title: Clinical analysis of endometrial cancer patients with obesity, diabetes, and hypertension.
abstract: The purpose of our study was to study the postoperation outcome and incidence of deep vein thrombosis (DVT) in endometrial cancer (EC) patients with or without hypertension, diabetes, and obesity. This analysis included 219 patients with endometrial carcinoma who were treated between 2002 and 2012 at the Department of Obstetrics and Gynecology, Yangzhou University Hospital. Patients were divided into five groups based on the comorbidities. Group 1 EC & Diabetes, Group 2 EC & Hypertension, Group 3 EC & Obesity, Group 4 EC Combined two, Group 5 no combined. Then the five groups were analyzed in postoperation outcomes and DVT incidence using one-way analysis of variance or Pearson χ(2) tests. we found that there was no significant difference in pelvic lymph node metastasis (P=0.102), aortic lymph node metastasis (P=0.221), and operative time (P=0.503). But there was significant difference in blood loss (P<0.01), hospital stay (P<0.01). No significant difference (P>0.05) in treatment outcome between surgical operation, surgical operation+ radiotherapy and radiotherapy. Deep vein thrombosis and pulmonary embolism have some significantly (P<0.01) (P<0.01), respectively. Compared to patients who simply suffer from endometrial cancer, diabetes make patients easy bleeding in surgery and increase hospitalization time in corresponding. VTE is a common complication of EC surgery with comorbidities, such as diabetes and hypertension, and it's a remarkable proportion of events occurring late after surgery.
authors.affiliation: Department of Obstetrics and Gynecology, Subei People's Hospital of Jiangsu Province, Clinical Medical College of Yangzhou University Yangzhou, 225000, Jiangsu Province, People's Republic of China.
authors.forename: Xiang-Hua
authors.initials: XH
authors.lastname: Yin
authors.affiliation: Department of Obstetrics and Gynecology, Subei People's Hospital of Jiangsu Province, Clinical Medical College of Yangzhou University Yangzhou, 225000, Jiangsu Province, People's Republic of China.
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Jia
authors.affiliation: Department of Obstetrics and Gynecology, Subei People's Hospital of Jiangsu Province, Clinical Medical College of Yangzhou University Yangzhou, 225000, Jiangsu Province, People's Republic of China.
authors.forename: Xiao-Rui
authors.initials: XR
authors.lastname: Xue
authors.affiliation: Department of Obstetrics and Gynecology, Subei People's Hospital of Jiangsu Province, Clinical Medical College of Yangzhou University Yangzhou, 225000, Jiangsu Province, People's Republic of China.
authors.forename: Shi-Zhang
authors.initials: SZ
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, Subei People's Hospital of Jiangsu Province, Clinical Medical College of Yangzhou University Yangzhou, 225000, Jiangsu Province, People's Republic of China.
authors.forename: Zhong-Qin
authors.initials: ZQ
authors.lastname: Wang
keywords: Endometrial carcinoma; diabetes mellitus; hypertension; obesity
references.citation: J Natl Cancer Inst. 1977 Oct;59(4):1055-60
references.pmid: 333120
references.citation: Cancer Causes Control. 2000 Feb;11(2):185-92
references.pmid: 10710204
references.citation: Int J Cancer. 2003 May 10;104(6):669-76
references.pmid: 12640672
references.citation: Nutr Cancer. 2003;46(2):119-24
references.pmid: 14690786
references.citation: Cancer Causes Control. 2000 Sep;11(8):707-11
references.pmid: 11065007
references.citation: Gynecol Oncol. 2000 Jul;78(1):58-61
references.pmid: 10873411
references.citation: Ann Surg. 2006 Jan;243(1):89-95
references.pmid: 16371741
references.citation: Diabetes Care. 2004 Jan;27 Suppl 1:S5-S10
references.pmid: 14693921
references.citation: Br J Cancer. 2007 Oct 22;97(8):1053-7
references.pmid: 17895896
references.citation: Cancer Epidemiol Biomarkers Prev. 2011 Nov;20(11):2384-95
references.pmid: 21921255
references.citation: Am J Epidemiol. 2008 Mar 1;167(5):607-14
references.pmid: 18071194
references.citation: Clin Appl Thromb Hemost. 2012 Jan-Feb;18(1):5-19
references.pmid: 21733942
references.citation: J Natl Cancer Inst. 2013 Mar 6;105(5):342-9
references.pmid: 23297041
references.citation: Haematologica. 1999 May;84(5):437-45
references.pmid: 10329923
references.citation: Obstet Gynecol. 2008 Feb;111(2 Pt 1):436-47
references.pmid: 18238985
references.citation: Cancer Epidemiol Biomarkers Prev. 2013 Jan;22(1):76-81
references.pmid: 23118146
references.citation: Clin Med (Lond). 2011 Oct;11(5):465-6
references.pmid: 22034707
references.citation: Thromb Haemost. 1997 Jul;78(1):631-5
references.pmid: 9198229
references.citation: J Clin Endocrinol Metab. 2012 Sep;97(9):3216-23
references.pmid: 22730518
references.citation: Obstet Gynecol. 2007 Aug;110(2 Pt 1):429-40
references.pmid: 17666620
references.citation: J Clin Pathol. 1989 Aug;42(8):805-9
references.pmid: 2475526
references.citation: J Gynecol Oncol. 2013 Jan;24(1):52-8
references.pmid: 23346314