title: Vitamin D and neurocognitive function.
abstract: In recent years, emerging evidence has linked vitamin D not only to its known effects on calcium and bone metabolism, but also to many chronic illnesses involving neurocognitive decline. The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an increasing portion of the population in developed countries has a significant vitamin D deficiency. The older population is at an especially high risk for vitamin D deficiency due to the decreased cutaneous synthesis and dietary intake of vitamin D. Recent studies have confirmed an association between cognitive impairment, dementia, and vitamin D deficiency. There is a need for well-designed randomized trials to assess the benefits of vitamin D and lifestyle interventions in persons with mild cognitive impairment and dementia.
authors.affiliation: University Center for Medicine of Aging Basel, University of Basel, Basel, Switzerland.
authors.forename: Mathias
authors.initials: M
authors.lastname: Schlögl
authors.affiliation: Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Holick
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000209:etiology; D003071:Cognition / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000209:etiology; D006801:Humans; D044342:Malnutrition / Q000150:complications; D014807:Vitamin D / Q000378:metabolism / Q000502:physiology*; D014808:Vitamin D Deficiency / Q000150:complications
chemical_list: D014807:Vitamin D
keywords: 25(OH)D level; Alzheimer’s disease; cognition; mild cognitive impairment; vascular dementia; vitamin D
references.citation: Endocrinology. 1997 Jan;138(1):12-8
references.pmid: 8977379
references.citation: Neurosci Lett. 2003 Jun 5;343(2):139-43
references.pmid: 12759183
references.citation: J Nutr Health Aging. 2013 Apr;17(4):295-9
references.pmid: 23538648
references.citation: Neuropsychobiology. 2010 Aug;62(3):139-50
references.pmid: 20628264
references.citation: J Alzheimers Dis. 2013;34(1):155-70
references.pmid: 23186989
references.citation: J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1205-11
references.pmid: 22503994
references.citation: Stroke. 2011 Sep;42(9):2672-713
references.pmid: 21778438
references.citation: Metabolism. 1999 Aug;48(8):1028-32
references.pmid: 10459569
references.citation: Lancet. 2013 Mar 2;381(9868):752-62
references.pmid: 23395245
references.citation: Neurology. 2001 Jun 26;56(12):1683-9
references.pmid: 11425934
references.citation: Neurology. 2012 Sep 25;79(13):1397-405
references.pmid: 23008220
references.citation: Clin Nutr. 2013 Dec;32(6):950-7
references.pmid: 23591150
references.citation: J Clin Invest. 2002 Jul;110(2):229-38
references.pmid: 12122115
references.citation: N Engl J Med. 2011 Jun 9;364(23):2227-34
references.pmid: 21651394
references.citation: Tohoku J Exp Med. 2007 Jul;212(3):275-82
references.pmid: 17592215
references.citation: Curr Opin Clin Nutr Metab Care. 2013 Jan;16(1):50-5
references.pmid: 23201650
references.citation: J Adv Nurs. 2003 Jan;41(2):162-9
references.pmid: 12519275
references.citation: Stroke. 2010 May;41(5):891-7
references.pmid: 20360538
references.citation: Kidney Int. 2008 Jul;74(2):170-9
references.pmid: 18385669
references.citation: J Alzheimers Dis. 2009;17(3):703-17
references.pmid: 19433889
references.citation: J Am Med Dir Assoc. 2009 Nov;10(9):653-7
references.pmid: 19883889
references.citation: Alzheimers Dement. 2012 Oct;8(5 Suppl):S104-11
references.pmid: 22537801
references.citation: Ann Neurol. 2013 Jan;73(1):38-47
references.pmid: 23225498
references.citation: J Chem Neuroanat. 2005 Jan;29(1):21-30
references.pmid: 15589699
references.citation: JAMA. 1997 Mar 12;277(10):813-7
references.pmid: 9052711
references.citation: Arch Med Sci. 2012 Feb 29;8(1):4-5
references.pmid: 22457665
references.citation: Nutrients. 2013 Jul 31;5(8):3005-21
references.pmid: 23912328
references.citation: Lancet. 1995 Jul 22;346(8969):207-10
references.pmid: 7616799
references.citation: Brain. 2012 Dec;135(Pt 12):3749-56
references.pmid: 23204143
references.citation: J Biol Chem. 2004 Aug 20;279(34):35798-802
references.pmid: 15205460
references.citation: Drugs Aging. 2011 Jan 1;28(1):1-11
references.pmid: 21174483
references.citation: Ann Neurol. 2007 Oct;62(4):406-13
references.pmid: 17879383
references.citation: Lancet Neurol. 2005 Aug;4(8):487-99
references.pmid: 16033691
references.citation: Alzheimers Dement. 2011 Jul;7(4):436-44
references.pmid: 21388893
references.citation: Lancet. 1989 Nov 4;2(8671):1104-5
references.pmid: 2572832
references.citation: Dementia. 1994 May-Aug;5(3-4):130-2
references.pmid: 8087166
references.citation: Free Radic Biol Med. 2003 Jun 1;34(11):1416-25
references.pmid: 12757852
references.citation: J Korean Med Sci. 2005 Jun;20(3):495-8
references.pmid: 15953876
references.citation: J Gerontol A Biol Sci Med Sci. 2012 Oct;67(10):1092-8
references.pmid: 22454371
references.citation: Circulation. 1997 Sep 16;96(6):1755-60
references.pmid: 9323058
references.citation: Clin Endocrinol (Oxf). 2011 Nov;75(5):575-84
references.pmid: 21682758
references.citation: Neurosci Lett. 2011 Oct 24;504(2):79-82
references.pmid: 21911036
references.citation: Cell. 1995 Dec 15;83(6):835-9
references.pmid: 8521507
references.citation: J Geriatr Psychiatry Neurol. 2005 Dec;18(4):224-7
references.pmid: 16306244
references.citation: J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30
references.pmid: 21646368
references.citation: Am J Clin Nutr. 2012 Jan;95(1):163-78
references.pmid: 22170372
references.citation: Acta Neuropathol. 2010 Sep;120(3):287-96
references.pmid: 20623294
references.citation: QJM. 2013 Sep;106(9):809-21
references.pmid: 23657707
references.citation: Lancet Neurol. 2013 Aug;12(8):811-21
references.pmid: 23867199
references.citation: B-ENT. 2009;5 Suppl 13:129-32
references.pmid: 20084814
references.citation: Mol Endocrinol. 1997 Dec;11(13):1961-70
references.pmid: 9415400
references.citation: Arch Intern Med. 2010 Jul 12;170(13):1135-41
references.pmid: 20625021
references.citation: Hippocampus. 2010 Jun;20(6):696-705
references.pmid: 19603526
references.citation: Neurosci Lett. 2013 Sep 13;551:70-4
references.pmid: 23880018
references.citation: J Neurol Neurosurg Psychiatry. 2002 Oct;73(4):371-6
references.pmid: 12235302
references.citation: Neurobiol Aging. 2000 Jan-Feb;21(1):49-55
references.pmid: 10794848
references.citation: Proc Natl Acad Sci U S A. 2006 May 9;103(19):7327-32
references.pmid: 16648267
references.citation: Tohoku J Exp Med. 2012;228(3):189-96
references.pmid: 23076256
references.citation: J Alzheimers Dis. 2009;17(1):151-9
references.pmid: 19494440
references.citation: Gen Physiol Biophys. 2013 Dec;32(4):459-66
references.pmid: 24067280
references.citation: J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):610-3
references.pmid: 17236758
references.citation: Glia. 1998 Mar;22(3):282-94
references.pmid: 9482214
references.citation: J Clin Endocrinol Metab. 2009 Oct;94(10):4023-30
references.pmid: 19584181
references.citation: Neurology. 2007 Dec 11;69(24):2197-204
references.pmid: 17568013
references.citation: Neurobiol Aging. 2009 Mar;30(3):466-73
references.pmid: 17714831
references.citation: Neurology. 1992 Mar;42(3 Pt 1):473-80
references.pmid: 1549205
references.citation: J Am Soc Nephrol. 2009 Aug;20(8):1805-12
references.pmid: 19443637
references.citation: J Cereb Blood Flow Metab. 2013 Nov;33(11):1696-706
references.pmid: 24022624
references.citation: Curr Pharm Des. 2010;16(6):619-30
references.pmid: 20388072
references.citation: J Am Geriatr Soc. 2011 Jan;59(1):169-71
references.pmid: 21226693
references.citation: Dermatoendocrinol. 2011 Oct;3(4):243-50
references.pmid: 22259652
references.citation: Neurology. 1993 Feb;43(2):250-60
references.pmid: 8094895
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16810-5
references.pmid: 17942703
references.citation: Brain Res Mol Brain Res. 1994 Jul;24(1-4):70-6
references.pmid: 7968379
references.citation: N Engl J Med. 2007 Jul 19;357(3):266-81
references.pmid: 17634462
references.citation: Neurology. 2001 Jan 9;56(1):42-8
references.pmid: 11148234
references.citation: Metabolism. 1991 May;40(5):524-8
references.pmid: 1902546
references.citation: Nat Rev Nephrol. 2013 Jun;9(6):337-47
references.pmid: 23609564
references.citation: J Neurosci. 2001 Jan 1;21(1):98-108
references.pmid: 11150325
references.citation: J Neurosci Res. 1991 Jan;28(1):110-4
references.pmid: 1904101
references.citation: Neuroepidemiology. 2007;29(1-2):125-32
references.pmid: 17975326
references.citation: J Am Med Dir Assoc. 2010 May;11(4):296
references.pmid: 20439051
references.citation: Biochemistry. 1998 Apr 28;37(17):5988-94
references.pmid: 9558335
references.citation: J Alzheimers Dis. 2013;33(3):659-74
references.pmid: 23042216
references.citation: Int J Neurosci. 2013 Jan;123(1):60-4
references.pmid: 22947263
references.citation: J Am Coll Nutr. 2002 Aug;21(4):357-62
references.pmid: 12166534
references.citation: Neuropharmacology. 2001 May;40(6):761-71
references.pmid: 11369030
references.citation: Neurosci Lett. 2012 Sep 6;525(1):29-33
references.pmid: 22842395
references.citation: Neurology. 2004 Apr 13;62(7):1148-55
references.pmid: 15079015
references.citation: Am J Geriatr Pharmacother. 2010 Feb;8(1):4-33
references.pmid: 20226390
references.citation: Clin Nutr. 2013 Dec;32(6):1007-11
references.pmid: 23755842
references.citation: J Invest Dermatol. 2001 Nov;117(5):1179-85
references.pmid: 11710930
references.citation: J Invest Dermatol. 1994 May;102(5):796-8
references.pmid: 8176265
references.citation: Nutr Metab Cardiovasc Dis. 2012 Feb;22(2):81-7
references.pmid: 22265795
references.citation: Mol Neurodegener. 2011 Dec 22;6:85
references.pmid: 22192775
references.citation: Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):7-14
references.pmid: 21102318
references.citation: J Am Med Dir Assoc. 2009 Nov;10(9):591-2
references.pmid: 19883878
references.citation: Dement Geriatr Cogn Disord. 2012;33(5):297-305
references.pmid: 22759681
references.citation: J Alzheimers Dis. 2009;18(3):691-701
references.pmid: 19749406
references.citation: J Clin Invest. 1985 Oct;76(4):1536-8
references.pmid: 2997282
references.citation: J Alzheimers Dis. 2013;37(1):147-71
references.pmid: 23948884
references.citation: Am J Hypertens. 2014 Jan;27(1):114-21
references.pmid: 24042165
references.citation: Mayo Clin Proc. 2013 Jul;88(7):720-55
references.pmid: 23790560
references.citation: Arch Neurol. 2007 Dec;64(12):1734-40
references.pmid: 18071036
references.citation: J Gerontol A Biol Sci Med Sci. 2005 Apr;60(4):499-505
references.pmid: 15933391
references.citation: Autoimmun Rev. 2013 Aug;12(10):976-89
references.pmid: 23542507
references.citation: Hypertension. 2010 May;55(5):1283-8
references.pmid: 20351344
references.citation: Am J Cardiol. 2010 Oct 1;106(7):963-8
references.pmid: 20854958
references.citation: Drugs Aging. 2007;24(12):1017-29
references.pmid: 18020534
references.citation: J Hypertens. 2009 Oct;27(10):1948-54
references.pmid: 19587609
references.citation: J Aging Res. 2013;2013:207178
references.pmid: 24083026
references.citation: Nat Rev Neurol. 2012 Mar 13;8(4):189-202
references.pmid: 22410582
references.citation: Arch Neurol. 2011 Jun;68(6):761-7
references.pmid: 21670400
references.citation: J Neurotrauma. 2008 Oct;25(10):1247-56
references.pmid: 18986226
references.citation: Circulation. 2011 Oct 25;124(17):1838-47
references.pmid: 21947295
references.citation: Recent Results Cancer Res. 2003;164:3-28
references.pmid: 12899511
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2003 Feb;117B(1):114-7
references.pmid: 12555245
references.citation: Ann N Y Acad Sci. 2003 May;993:313-24; discussion 345-9
references.pmid: 12853323
references.citation: Brain Res Mol Brain Res. 1992 Apr;13(3):239-50
references.pmid: 1317496
references.citation: Eur J Neurol. 2009 Oct;16(10):1083-9
references.pmid: 19659751
references.citation: Lancet. 1999 Sep 11;354(9182):919-20
references.pmid: 10489957
references.citation: Neurology. 2010 Jan 5;74(1):18-26
references.pmid: 19940273
references.citation: J Am Med Dir Assoc. 2013 Sep;14(9):649-55
references.pmid: 23639716
references.citation: Proc Nutr Soc. 2012 Nov;71(4):556-65
references.pmid: 22883349
references.citation: J Geriatr Psychiatry Neurol. 2009 Sep;22(3):188-95
references.pmid: 19073839
references.citation: J Biol Chem. 2002 Apr 12;277(15):13294-301
references.pmid: 11796720
references.citation: Lancet. 2005 Dec 17;366(9503):2112-7
references.pmid: 16360788
references.citation: Neuroreport. 1994 Dec 30;6(1):124-6
references.pmid: 7703399
references.citation: Nat Rev Neurol. 2013 Jul;9(7):371-81
references.pmid: 23752908
references.citation: J Clin Invest. 1980 Nov;66(5):1118-23
references.pmid: 6893596
references.citation: Ann Hum Genet. 2011 Mar;75(2):201-10
references.pmid: 21309754
references.citation: Circ Cardiovasc Qual Outcomes. 2012 Nov;5(6):819-29
references.pmid: 23149428
references.citation: J Neurol. 2002 Nov;249(11):1529-34
references.pmid: 12420093
references.citation: Neuroreport. 1996 Sep 2;7(13):2171-5
references.pmid: 8930983
references.citation: Anticancer Res. 2009 Sep;29(9):3659-67
references.pmid: 19667162
references.citation: Arch Osteoporos. 2012;7:155-72
references.pmid: 23225293
references.citation: Osteoporos Int. 2009 Jan;20(1):133-40
references.pmid: 18458986
references.citation: Ageing Res Rev. 2013 Sep;12(4):1013-23
references.pmid: 23727408
references.citation: J Neurol Sci. 2009 Aug 15;283(1-2):57-61
references.pmid: 19268313
references.citation: J Am Geriatr Soc. 2013 Jan;61(1):67-73
references.pmid: 23301925
references.citation: J Nutr. 2012 Mar;142(3):498-507
references.pmid: 22323766
references.citation: Am J Clin Nutr. 1993 Dec;58(6):882-5
references.pmid: 8249872
references.citation: J Cell Biochem. 2003 Feb 1;88(2):327-31
references.pmid: 12520534
references.citation: Lancet. 2001 Jan 20;357(9251):169-75
references.pmid: 11213093
references.citation: Neurology. 2010 Jan 5;74(1):33-41
references.pmid: 19940271
references.citation: Arch Dermatol Res. 1999 Sep;291(9):507-10
references.pmid: 10541881