title: Presence of quinolone resistance to qnrB1 genes and blaOXA-48 carbapenemase in clinical isolates of Klebsiella pneumoniae in Spain.
abstract: A study is presented on the presence of quinolone resistance qnrB1 genes in clinical isolates belonging to the largest series of infections caused by OXA-48-producing Klebsiella pneumoniae in a single-centre outbreak in Spain. Evidence is also provided, according to in vitro results, that there is a possibility of co-transfer of plasmid harbouring blaOXA-48 with an other plasmid harbouring qnrB1 in presence of low antibiotic concentrations of fluoroquinolones, showing the risk of multi-resistance screening.
authors.affiliation: Departamento de Microbiología, Universidad de Sevilla, Sevilla, Spain. Electronic address: jmrodriguez@us.es.
authors.forename: J M
authors.initials: JM
authors.lastname: Rodríguez Martínez
authors.affiliation: Unidad de Enfermedades Infeccionas y Microbiología Clínica, Hospital Universitario Virgen Macarena, Sevilla, Spain; Departamento de Microbiología, Universidad de Sevilla, Sevilla, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Díaz-de Alba
authors.affiliation: Departamento de Microbiología, Universidad de Sevilla, Sevilla, Spain; Unidad de Enfermedades Infeccionas y Microbiología Clínica, Hospital Universitario Virgen Macarena, Sevilla, Spain.
authors.lastname: Lopez-Cerero
authors.affiliation: Servicio de Microbiología, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Ruiz-Carrascoso
authors.affiliation: Servicio de Microbiología, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Gomez-Gil
authors.affiliation: Departamento de Microbiología, Universidad de Sevilla, Sevilla, Spain; Unidad de Enfermedades Infeccionas y Microbiología Clínica, Hospital Universitario Virgen Macarena, Sevilla, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Pascual
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D015363:Quinolones / Q000494:pharmacology*; D013030:Spain; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D015363:Quinolones; D001618:beta-Lactamases; C063912:carbapenemase
keywords: Carbapenems; PMQR; Resistencia a quinolonas mediada por plásmidos; bla(OXA-48); blaOXA-48; qnr