title: Spontaneous control of HIV replication, but not HAART-induced viral suppression, is associated with lower activation of immune cells.
abstract: HIV replication control is important to reduce AIDS progression. We determined frequency and activation status of immune cells in spontaneous HIV controllers vs. individuals with highly active antiretroviral therapy (HAART)-controlled viral load. HIV controllers exhibited significantly higher frequency of CD4 T cells and myeloid dendritic cells compared with HAART-controlled viral load. Additionally, HIV controllers have a significantly lower percentage of cells expressing activation markers on CD4 and CD8 T cells, myeloid dendritic cells, and natural killer cells. These findings suggest that during HIV infection, conservation of a normal frequency and physiological range of immune activation is associated with spontaneous, but not HAART-induced, control of viral replication.
authors.affiliation: Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia.
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Taborda
authors.forename: María T
authors.initials: MT
authors.lastname: Rugeles
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Montoya
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D006678:HIV / Q000187:drug effects / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000502:physiology; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects*; D055815:Young Adult
chemical_list: D015703:Antigens, CD