title: Pigmented oral carcinoma in situ: a case report and literature review.
abstract: Oral melanotic lesions, including melanin pigmentation, melanocytic nevus, and malignant melanoma, are well-recognized pathologic entities. However, melanocytic proliferation within malignant oral mucosal lesions is not well documented. We report the unusual case of a 53-year-old Japanese man who developed oral carcinoma in situ (CIS) with melanocytic proliferation and melanin pigmentation in the epithelial layer. The patient, a nonsmoker and an opportunistic drinker, presented with a brown tongue lesion. Initial examination found a large brown pigmented area and multiple small white patchy areas on the right tongue border. The pigmentation had an ill-defined border with uneven color distribution. Physical examination found no abnormalities. Ultrasonography did not find a deeply infiltrating lesion. Oral mucosal malignant melanoma in situ was diagnosed, and partial tongue resection was performed. Histopathologic examination found oral pigmented CIS. To the best of our knowledge, this is only the third reported case of oral pigmented CIS.
authors.affiliation: Assistant Professor, Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan. Electronic address: matsumoto.naoyuki@nihon-u.ac.jp.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Matsumoto
authors.affiliation: Postgraduate student, Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Taiichi
authors.initials: T
authors.lastname: Kitano
authors.affiliation: Professor, Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Hidero
authors.initials: H
authors.lastname: Oki
authors.affiliation: Postdoctoral Fellow, Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Omagari
authors.affiliation: Postgraduate student, Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Matsue
authors.affiliation: Postgraduate student, Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Michisato
authors.initials: M
authors.lastname: Okudera
authors.affiliation: Postgraduate student, Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamamura
authors.affiliation: Postgraduate student, Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Yohichi
authors.initials: Y
authors.lastname: Nishikawa
authors.affiliation: Assistant Professor, Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishimura
authors.affiliation: Associate Professor, Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Masatake
authors.initials: M
authors.lastname: Asano
authors.affiliation: Professor, Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Komiyama
mesh_terms: D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery