title: [The influence of age of donors on the ability of cells to homologous recombination DNA repair].
abstract: Old and young donors cells show different ability to homologous recombination (shown on the first stage--the chromosome transference) in vitro, that we suppose could be the reasons of the genome instability in aging. Homologous recombination, induced by X-radiation, is limited in cells taken from donors older than 70 years. Alpha-amanitin, the RNA-polymerize II repressor, in toxic doze, could induce the chromosome transference in the cells from all studied groups: from old and young donors and donors with repair process defect (with BRCA 1, 2 mutations). Summarized effect of X-radiation and alpha-amanitin does not increase the induction of the chromosome transference.
authors.forename: A
authors.initials: A
authors.lastname: Bernadotte
authors.forename: V M
authors.initials: VM
authors.lastname: Mikhel'son
authors.forename: I M
authors.initials: IM
authors.lastname: Spivak
authors.forename: G A
authors.initials: GA
authors.lastname: Ryzhak
mesh_terms: D000367:Age Factors; D053959:Alpha-Amanitin / Q000494:pharmacology*; D002869:Chromosome Aberrations / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D042822:Genomic Instability / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D012319:RNA Polymerase II / Q000502:physiology; D059767:Recombinational DNA Repair / Q000187:drug effects / Q000528:radiation effects; D014019:Tissue Donors; D014965:X-Rays / Q000009:adverse effects*
chemical_list: D053959:Alpha-Amanitin; D019384:Nucleic Acid Synthesis Inhibitors; D012319:RNA Polymerase II