title: [Expression and clinical significance of bone morphogenetic protein 6 in human breast cancer].
abstract: OBJECTIVE
  To investigate the expression pattern and clinical significance of bone morphogenetic protein 6 (BMP6) in breast tissues.
  
  
  METHODS
  The tumor and adjacent noncancerous tissues were harvested from 36 cases of breast cancer, the expression level of BMP6 mRNA of each sample was measured by quantitative RT-PCR. Immunohistochemistry study was used to examine BMP6 protein expression in 80 cases of breast cancer, then the relationship between the expression of BMP6 and relevant clinical and pathological parameters was analyzed.
  
  
  RESULTS
  BMP6 mRNA expression in breast cancer was significantly reduced when compared with normal breast tissues (P< 0.01), BMP6 mRNA level in estrogen receptor-positive (ER) breast cancer was distinctly higher than that in ER breast cancer. The expression of BMP6 mRNA was correlated to tumor grade (P < 0.01). The expression level of BMP6 protein in breast cancer was associated to ER and PR status, histological grade and Ki-67 status (P < 0.05), but not correlated to age, tumor size, human epidermal factor receptor 2 (Her2) status and molecular subtypes of breast cancer (P > 0.05).
  
  
  CONCLUSIONS
  The ectopic expression of BMP6 may play an important role in the development and progression of breast cancer.
authors.forename: Geng
authors.initials: G
authors.lastname: Liu
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Lian
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Zhou
authors.forename: Ming-Jiang
authors.initials: MJ
authors.lastname: Bie
mesh_terms: D055418:Bone Morphogenetic Protein 6 / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D012333:RNA, Messenger; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
chemical_list: C525816:BMP6 protein, human; D055418:Bone Morphogenetic Protein 6; D019394:Ki-67 Antigen; D012333:RNA, Messenger; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone