title: Detection of sentinel lymph node in breast cancer recurrence may change adjuvant treatment decision in patients with breast cancer recurrence and previous axillary surgery.
abstract: Use of sentinel lymph node dissection in patients with ipsilateral breast cancer recurrence is still controversial. The objective of this study is to evaluate the feasibility of the sentinel lymph node in breast cancer recurrence (SLNBR) and whether the positivity had impact in the adjuvant treatment. Between 2008 and 2012 we performed SLNBR in patients with ipsilateral breast tumor recurrence. We included 53 patients in a prospective study. Forty-three patients (81%) had a previous axillary lymph node dissection (ALND) and ten (19%) had a previous sentinel lymph node biopsy (SLNB). Identification rate after SLNB was 50% and after ALND was 60.5% (p = 0.4). Nine patients (26%) had a positive SLNBR. Adjuvant systemic treatment was given to all the patients with a positive SLNBR and to 23 (85%) with a negative SLNBR (p = 0.29). Six patients (66%) with positive SLNBR and 4 patients (14%) with negative SLNBR underwent radiation therapy (p < 0.01). As conclusions of our study we conclude that sentinel lymph node biopsy in breast tumor recurrence is feasible and significant differences were found in the use of radiation therapy in patients with a positive SLNBR.
authors.affiliation: Centre de Càncer de Mama Vall d'Hebron, Service of Gynecology, Hospital Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Unitat docent Vall d'Hebron, Vall d'Hebron 119-129, 08035 Barcelona, Spain. Electronic address: ocordoba@vhebron.net.
authors.forename: Octavi
authors.initials: O
authors.lastname: Cordoba
authors.affiliation: Facultat de Medicina, Universitat Autònoma de Barcelona, Unitat docent Vall d'Hebron, Vall d'Hebron 119-129, 08035 Barcelona, Spain; Service of Gynecology, Hospital Universitari Hospital Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Perez-Ceresuela
authors.affiliation: Centre de Càncer de Mama Vall d'Hebron, Service of Gynecology, Hospital Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.
authors.forename: Martin
authors.initials: M
authors.lastname: Espinosa-Bravo
authors.affiliation: Centre de Càncer de Mama Vall d'Hebron, Service of Gynecology, Hospital Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.
authors.forename: Tomas
authors.initials: T
authors.lastname: Cortadellas
authors.affiliation: Centre de Càncer de Mama Vall d'Hebron, Service of Gynecology, Hospital Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Esgueva
authors.affiliation: Centre de Càncer de Mama Vall d'Hebron, Service of Gynecology, Hospital Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.
authors.forename: Robert
authors.initials: R
authors.lastname: Rodriguez-Revuelto
authors.affiliation: Facultat de Medicina, Universitat Autònoma de Barcelona, Unitat docent Vall d'Hebron, Vall d'Hebron 119-129, 08035 Barcelona, Spain; Service of Pathology, Hospital Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Peg
authors.affiliation: Service of Radiation Oncology, Hospital Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Reyes
authors.affiliation: Facultat de Medicina, Universitat Autònoma de Barcelona, Unitat docent Vall d'Hebron, Vall d'Hebron 119-129, 08035 Barcelona, Spain; Service of Gynecology, Hospital Universitari Hospital Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Xercavins
authors.affiliation: Centre de Càncer de Mama Vall d'Hebron, Service of Gynecology, Hospital Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Unitat docent Vall d'Hebron, Vall d'Hebron 119-129, 08035 Barcelona, Spain.
authors.forename: Isabel T
authors.initials: IT
authors.lastname: Rubio
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000628:therapy*; D018275:Carcinoma, Lobular / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D018714:Radiotherapy, Adjuvant; D021701:Sentinel Lymph Node Biopsy
keywords: Breast cancer; Local surgery; Neoplasms recurrence; Sentinel lymph node biopsy