title: Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka.
abstract: Four cyclohexanol analogues, dendrodochols A-D (1-4), were isolated from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka collected from the South China Sea. The structures were elucidated by means of detailed spectroscopic analysis. The absolute configurations were assigned using a solution TDDFT/ECD calculation approach and the modified Mosher's method. In an in vitro bioassay, these compounds exhibited no growth inhibition activity against the A549 and MG63 cell lines. Dendrodochols 1 and 3 exhibited modest antifungal activity against Candida strains, Cryptococcus neoformans, and Trichophyton rubrum, whereas 2 and 4 showed no activity against the tested strains.
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University , 325 Guo-He Road, Shanghai 200433, People's Republic of China.
authors.forename: Dong-Xiao
authors.initials: DX
authors.lastname: Xu
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.forename: Tibor
authors.initials: T
authors.lastname: Kurtán
authors.forename: Attila
authors.initials: A
authors.lastname: Mándi
authors.forename: Hua
authors.initials: H
authors.lastname: Tang
authors.forename: Baoshu
authors.initials: B
authors.lastname: Liu
authors.forename: William H
authors.initials: WH
authors.lastname: Gerwick
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Wang
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003455:Cryptococcus neoformans / Q000187:drug effects; D003511:Cyclohexanols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047332:Holothuria / Q000737:chemistry*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009792:Oceans and Seas; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D003511:Cyclohexanols