title: PAQR-2 may be a regulator of membrane fluidity during cold adaptation.
abstract: PAQR-2 is a C. elegans homolog of the mammalian adiponectin receptors. We have recently shown that PAQR-2 is essential for the ability of C. elegans to grow at its lower temperature range, i.e., 15 °C, and that the likely role of PAQR-2 during cold adaptation is to regulate membrane fluidity by promoting fatty acid desaturation. Here we present a summary of this work, with an emphasis on placing our C. elegans findings in the context of mammalian biology.
authors.affiliation: Department of Chemistry and Molecular Biology; University of Gothenburg; Medicinaregatan 9C; Gothenburg, Sweden.
authors.forename: Marc
authors.initials: M
authors.lastname: Pilon
authors.affiliation: Department of Chemistry and Molecular Biology; University of Gothenburg; Medicinaregatan 9C; Gothenburg, Sweden.
authors.forename: Emma
authors.initials: E
authors.lastname: Svensk
keywords: AdipoR1; AdipoR2; CREST proteins; NHR-49; PAQR; SBP-1; adiponectin; cold adaptation; desaturases; membrane fluidity
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