title: Metabolomics approach in allergic and rheumatic diseases.
abstract: Metabolomics is the analysis of the concentration profiles of low molecular weight compounds present in biological fluids. Metabolites are nonpeptide molecules representing the end products of cellular activity. Therefore, changes in metabolite concentrations reveal the range of biochemical effects induced by a disease or its therapeutic intervention. Metabolomics has recently become feasible with the accessibility of new technologies, including mass spectrometry and high-resolution proton nuclear magnetic resonance, and has already been applied to several disorders. Indeed, it has the advantage of being a nontargeted approach for identifying potential biomarkers, which means that it does not require a preliminary knowledge of the substances to be studied. In this review, we summarize the main studies in which metabolomic approach was used in some allergic (asthma, atopic dermatitis) and rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus) to explore the feasibility of this technique as a novel diagnostic tool in these complex disorders.
authors.affiliation: Dipartimento di Medicina Interna e Specialità Mediche, Reumatologia, Sapienza Università di Roma, Viale del Policlinico 155, 00161, Rome, Italy, rossana.scrivo@uniroma1.it.
authors.forename: Rossana
authors.initials: R
authors.lastname: Scrivo
authors.forename: Luca
authors.initials: L
authors.lastname: Casadei
authors.forename: Mariacristina
authors.initials: M
authors.lastname: Valerio
authors.forename: Roberta
authors.initials: R
authors.lastname: Priori
authors.forename: Guido
authors.initials: G
authors.lastname: Valesini
authors.forename: Cesare
authors.initials: C
authors.lastname: Manetti
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D034721:Mastocytosis, Systemic / Q000276:immunology / Q000378:metabolism; D055432:Metabolomics; D012216:Rheumatic Diseases / Q000276:immunology* / Q000378:metabolism
references.citation: Ann Rheum Dis. 2011 Oct;70(10):1713-8
references.pmid: 21784723
references.citation: Ann Rheum Dis. 1991 Jun;50(6):366-8
references.pmid: 1829348
references.citation: Arthritis Rheum. 2013 Jun;65(6):1448-56
references.pmid: 23460124
references.citation: J Proteome Res. 2007 Feb;6(2):469-79
references.pmid: 17269704
references.citation: Mass Spectrom Rev. 2007 Jan-Feb;26(1):51-78
references.pmid: 16921475
references.citation: Clin Exp Rheumatol. 2012 Mar-Apr;30(2):240-5
references.pmid: 22410098
references.citation: Exp Ther Med. 2012 Jul;4(1):165-171
references.pmid: 23060942
references.citation: Allergy. 2013 Aug;68(8):1050-6
references.pmid: 23888905
references.citation: Eur Neurol. 1999 Jul;42(1):41-8
references.pmid: 10394047
references.citation: Autoimmun Rev. 2013 Aug;12(10):1022-30
references.pmid: 23688955
references.citation: Allergy. 2004 May;59(5):469-78
references.pmid: 15080825
references.citation: J Rheumatol. 2012 Feb;39(2):212-7
references.pmid: 22174195
references.citation: Lupus. 2011 Nov;20(13):1411-20
references.pmid: 21976403
references.citation: N Biotechnol. 2012 Sep 15;29(6):613-24
references.pmid: 22450380
references.citation: Mol Biosyst. 2012 Apr;8(5):1535-43
references.pmid: 22419152
references.citation: Nat Rev Drug Discov. 2002 Feb;1(2):153-61
references.pmid: 12120097
references.citation: Am J Respir Crit Care Med. 2009 Jan 1;179(1):25-34
references.pmid: 18931331
references.citation: J Invest Dermatol. 2009 Feb;129(2):320-2
references.pmid: 18719604
references.citation: J Allergy Clin Immunol. 2011 Mar;127(3):757-64.e1-6
references.pmid: 21377043
references.citation: J Cereb Blood Flow Metab. 1988 Apr;8(2):193-200
references.pmid: 3343294
references.citation: PLoS One. 2012;7(6):e37210
references.pmid: 22723834
references.citation: J Proteome Res. 2010 Sep 3;9(9):4545-53
references.pmid: 20701312
references.citation: Am Rev Respir Dis. 1992 Mar;145(3):669-74
references.pmid: 1546849
references.citation: PLoS One. 2014 Feb 05;9(2):e88223
references.pmid: 24505438
references.citation: J Proteome Res. 2007 Sep;6(9):3456-64
references.pmid: 17696462
references.citation: Br J Dermatol. 2012 May;166(5):1123-5
references.pmid: 22032695
references.citation: Analyst. 2002 Dec;127(12):1549-57
references.pmid: 12537357
references.citation: Biochim Biophys Acta. 2012 Nov;1821(11):1415-24
references.pmid: 22841830
references.citation: Arthritis Res Ther. 2011;13(6):R199
references.pmid: 22152586
references.citation: Allergy. 2013 Jan;68(1):110-7
references.pmid: 23157191
references.citation: Biomed Chromatogr. 2012 Jan;26(1):89-94
references.pmid: 21465502
references.citation: PLoS One. 2012;7(9):e44331
references.pmid: 22984493
references.citation: Treat Respir Med. 2005;4(5):309-16
references.pmid: 16137188
references.citation: Am J Respir Crit Care Med. 2007 May 15;175(10):986-90
references.pmid: 17303796
references.citation: Development. 2008 Feb;135(4):609-20
references.pmid: 18184729
references.citation: Lancet. 2010 Sep 25;376(9746):1094-108
references.pmid: 20870100
references.citation: Front Med. 2011 Jun;5(2):219-28
references.pmid: 21695629
references.citation: Philos Trans R Soc Lond B Biol Sci. 2004 Jun 29;359(1446):857-71
references.pmid: 15306403
references.citation: Autoimmun Rev. 2009 Mar;8(5):431-7
references.pmid: 19211043
references.citation: Philos Trans R Soc Lond B Biol Sci. 2006 Jan 29;361(1465):147-61
references.pmid: 16553314
references.citation: N Engl J Med. 2008 Apr 3;358(14):1483-94
references.pmid: 18385500
references.citation: Curr Opin Pharmacol. 2003 Jun;3(3):244-50
references.pmid: 12810187
references.citation: Neurochem Int. 2005 Jul;47(1-2):143-51
references.pmid: 15893408
references.citation: Mass Spectrom Rev. 2010 Nov-Dec;29(6):930-44
references.pmid: 20949635
references.citation: Clin Exp Allergy. 2013 Apr;43(4):425-33
references.pmid: 23517038
references.citation: Am J Respir Cell Mol Biol. 2013 Feb;48(2):204-11
references.pmid: 23144334
references.citation: Ann Rheum Dis. 2014 May;73(5):861-70
references.pmid: 23572339
references.citation: Photochem Photobiol Sci. 2008 Jun;7(6):655-67
references.pmid: 18528548
references.citation: Clin Chim Acta. 1999 Mar;281(1-2):163-7
references.pmid: 10217637
references.citation: Plant Mol Biol. 2002 Jan;48(1-2):155-71
references.pmid: 11860207
references.citation: Arthritis Res Ther. 2011 Feb 08;13(1):R19
references.pmid: 21303541
references.citation: J Clin Invest. 1997 Nov 1;100(9):2254-62
references.pmid: 9410903
references.citation: Arthritis Rheum. 2013 Aug;65(8):2015-23
references.pmid: 23740368
references.citation: Allergy. 2012 Dec;67(12):1475-82
references.pmid: 23106343
references.citation: Nature. 2012 Nov 15;491(7424):384-92
references.pmid: 23151581
references.citation: Lancet. 2002 Nov 30;360(9347):1715-21
references.pmid: 12480423
references.citation: Eur Respir J. 2005 Sep;26(3):523-48
references.pmid: 16135737
references.citation: Pediatr Pulmonol. 2007 Aug;42(8):723-8
references.pmid: 17598172