title: Novel method of tetramic acid synthesis: silver-catalyzed carbon dioxide incorporation into propargylic amine and intramolecular rearrangement.
abstract: Tetramic acid derivatives have been studied as biologically active heterocycle structures for pharmaceutical or agricultural chemicals. Conventional preparative approaches often require highly functionalized starting materials and harsh heating conditions in basic media. The present report provides a conceptually new synthetic strategy for the synthesis of tetramic acid derivatives from easily available propargylic amines and carbon dioxide with a silver salt and DBU under mild reaction conditions.
authors.affiliation: Department of Chemistry, Keio University , 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-5822, Japan.
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Ishida
authors.forename: Ryo
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Tohru
authors.initials: T
authors.lastname: Yamada
mesh_terms: D002245:Carbon Dioxide / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010293:Pargyline / Q000031:analogs & derivatives* / Q000737:chemistry; D011437:Propylamines / Q000737:chemistry*; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D011437:Propylamines; D011760:Pyrrolidinones; D002245:Carbon Dioxide; C009054:propargylamine; D012834:Silver; C009435:tetramic acid; D010293:Pargyline