title: Recent insights in the paracrine modulation of cardiomyocyte contractility by cardiac endothelial cells.
abstract: The cardiac endothelium is formed by a continuous monolayer of cells that line the cavity of the heart (endocardial endothelial cells (EECs)) and the luminal surface of the myocardial blood vessels (intramyocardial capillary endothelial cells (IMCEs)). EECs and IMCEs can exercise substantial control over the contractility of cardiomyocytes by releasing various factors such as nitric oxide (NO) via a constitutive endothelial NO-synthase (eNOS), endothelin-1, prostaglandins, angiotensin II, peptide growth factors, and neuregulin-1. The purpose of the present paper is actually to shortly review recent new information concerning cardiomyocytes as effectors of endothelium paracrine signaling, focusing particularly on contractile function. The modes of action and the regulatory paracrine role of the main mediators delivered by cardiac endothelial cells upon cardiac contractility identified in cardiomyocytes are complex and not fully described. Thus, careful evaluation of new therapeutic approaches is required targeting important physiological signaling pathways, some of which have been until recently considered as deleterious, like reactive oxygen species. Future works in the field of cardiac endothelial cells and cardiac function will help to better understand the implication of these mediators in cardiac physiopathology.
authors.affiliation: Inserm UMR 1063 (Stress Oxydant et Pathologies Métaboliques (SOPAM)), Institut de Biologie en Santé-IRIS, 4 rue Larrey CHU, 49933 Angers Cedex 9, France.
authors.forename: Jacques
authors.identifier: 0000-0002-6491-2100
authors.initials: J
authors.lastname: Noireaud
authors.affiliation: Inserm UMR 1063 (Stress Oxydant et Pathologies Métaboliques (SOPAM)), Institut de Biologie en Santé-IRIS, 4 rue Larrey CHU, 49933 Angers Cedex 9, France.
authors.forename: Ramaroson
authors.initials: R
authors.lastname: Andriantsitohaina
mesh_terms: D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D019332:Endothelin-1 / Q000378:metabolism; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000378:metabolism*; D020890:Neuregulin-1 / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D019899:Paracrine Communication / Q000502:physiology*
chemical_list: D019332:Endothelin-1; C094131:NRG1 protein, human; D020890:Neuregulin-1; D000804:Angiotensin II; D009569:Nitric Oxide; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III
references.citation: Naunyn Schmiedebergs Arch Pharmacol. 2001 May;363(5):577-82
references.pmid: 11383720
references.citation: Circulation. 2001 Jan 2;103(1):113-8
references.pmid: 11136695
references.citation: Trends Cardiovasc Med. 2003 Feb;13(2):80-6
references.pmid: 12586444
references.citation: Br J Pharmacol. 2002 Jun;136(3):415-20
references.pmid: 12023944
references.citation: Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H96-106
references.pmid: 16055523
references.citation: Trends Pharmacol Sci. 1997 Dec;18(12):484-91
references.pmid: 9458697
references.citation: J Mol Cell Cardiol. 2008 Mar;44(3):520-6
references.pmid: 18275971
references.citation: J Mol Cell Cardiol. 1999 Mar;31(3):619-29
references.pmid: 10198192
references.citation: Annu Rev Pharmacol Toxicol. 2001;41:851-76
references.pmid: 11264479
references.citation: Front Physiol. 2013 May 30;4:126
references.pmid: 23755021
references.citation: Prog Cardiovasc Dis. 1996 Nov-Dec;39(3):239-62
references.pmid: 8970576
references.citation: Circ Res. 1991 Aug;69(2):301-12
references.pmid: 1860176
references.citation: J Biol Chem. 1995 Jun 16;270(24):14582-6
references.pmid: 7540173
references.citation: Antioxid Redox Signal. 2009 Mar;11(3):669-702
references.pmid: 19014277
references.citation: Am J Physiol. 1995 Jan;268(1 Pt 2):H250-9
references.pmid: 7840269
references.citation: Am J Physiol. 1993 Nov;265(5 Pt 2):H1841-6
references.pmid: 8238598
references.citation: Physiol Rev. 2009 Apr;89(2):481-534
references.pmid: 19342613
references.citation: Science. 2001 Sep 28;293(5539):2449-52
references.pmid: 11498544
references.citation: Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H598-605
references.pmid: 12124207
references.citation: Circulation. 1990 Dec;82(6):1973-84
references.pmid: 2242522
references.citation: J Biol Chem. 1993 Dec 15;268(35):26286-95
references.pmid: 7902837
references.citation: Ann Cardiol Angeiol (Paris). 2003 Feb;52(1):41-51
references.pmid: 12710294
references.citation: Cardiovasc Res. 1998 May;38(2):281-90
references.pmid: 9709389
references.citation: Br J Pharmacol. 2013 Jan;168(2):296-317
references.pmid: 22946456
references.citation: Pharmacol Rep. 2005;57 Suppl:120-6
references.pmid: 16415492
references.citation: Nat Med. 2002 May;8(5):459-65
references.pmid: 11984589
references.citation: J Am Coll Cardiol. 2011 Mar 1;57(9):1053-61
references.pmid: 21349396
references.citation: FASEB J. 2001 Oct;15(12):2291-3
references.pmid: 11511516
references.citation: Circulation. 2004 Jan 27;109(3):324-6
references.pmid: 14732742
references.citation: Antioxid Redox Signal. 2013 Mar 20;18(9):1078-99
references.pmid: 22871241
references.citation: Arterioscler Thromb Vasc Biol. 2006 May;26(5):1015-21
references.pmid: 16514082
references.citation: Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1327-35
references.pmid: 21278135
references.citation: Circ Res. 2000 May 12;86(9):946-51
references.pmid: 10807866
references.citation: Circulation. 1993 Sep;88(3):1228-37
references.pmid: 8394785
references.citation: J Cardiovasc Electrophysiol. 2001 Nov;12(11):1295-301
references.pmid: 11761419
references.citation: Pharmacology. 2003 Mar;67(3):157-62
references.pmid: 12571412
references.citation: J Physiol. 2002 Apr 15;540(Pt 2):411-24
references.pmid: 11956332
references.citation: Br J Pharmacol. 2012 Mar;165(5):1288-305
references.pmid: 22014080
references.citation: Physiol Rev. 2003 Jan;83(1):59-115
references.pmid: 12506127
references.citation: Circulation. 1988 Jun;77(6 Pt 2):I4-13
references.pmid: 3286045
references.citation: J Physiol. 2003 Jan 1;546(Pt 1):63-75
references.pmid: 12509479
references.citation: Circ Res. 2010 Mar 5;106(4):633-46
references.pmid: 20203313
references.citation: FASEB J. 2001 Jan;15(1):79-89
references.pmid: 11149895
references.citation: Nitric Oxide. 2009 Feb;20(1):53-60
references.pmid: 18951990
references.citation: J Mol Cell Cardiol. 2001 Mar;33(3):503-11
references.pmid: 11181018
references.citation: Comp Biochem Physiol A Mol Integr Physiol. 2005 Oct;142(2):136-43
references.pmid: 15927494
references.citation: Nature. 1998 Apr 23;392(6678):821-4
references.pmid: 9580552
references.citation: J Cardiovasc Electrophysiol. 2006 May;17 Suppl 1:S134-S140
references.pmid: 16686668
references.citation: Basic Res Cardiol. 1992 Jan-Feb;87(1):2-11
references.pmid: 1314558
references.citation: J Physiol. 1999 Dec 1;521 Pt 2:375-88
references.pmid: 10581309
references.citation: Circ Res. 1993 Mar;72(3):526-38
references.pmid: 7679333
references.citation: Cell. 2001 Sep 21;106(6):675-83
references.pmid: 11572774
references.citation: Circulation. 2008 Oct 14;118(16):1651-8
references.pmid: 18824646
references.citation: Circ Res. 2001 Mar 2;88(4):376-82
references.pmid: 11230103
references.citation: Life Sci. 2000;66(7):607-15
references.pmid: 10794516
references.citation: Life Sci. 2002 Jan 25;70(10):1173-84
references.pmid: 11848301
references.citation: Endocrinology. 2009 Aug;150(8):3735-41
references.pmid: 19342458
references.citation: Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1473-80
references.pmid: 18203845
references.citation: J Histochem Cytochem. 2005 Jan;53(1):87-91
references.pmid: 15637341
references.citation: Curr Vasc Pharmacol. 2004 Jan;2(1):53-63
references.pmid: 15320833
references.citation: Cardiovasc Res. 1998 Dec;40(3):538-45
references.pmid: 10070495
references.citation: Cardiovasc Res. 2006 Jul 15;71(2):310-21
references.pmid: 16581043
references.citation: Free Radic Biol Med. 2011 Apr 1;50(7):777-93
references.pmid: 21236334
references.citation: Cardiovasc Res. 1995 May;29(5):637-40
references.pmid: 7541716
references.citation: J Pharmacol Sci. 2006;100(5):525-37
references.pmid: 16799263
references.citation: Cardiovasc Res. 1996 Oct;32(4):720-32
references.pmid: 8915190
references.citation: Cardiovasc Drugs Ther. 1994 Oct;8(5):701-17
references.pmid: 7873467
references.citation: J Mol Cell Cardiol. 1997 Nov;29(11):3057-65
references.pmid: 9405180
references.citation: Circ Res. 1999 May 14;84(9):1020-31
references.pmid: 10325239
references.citation: Cardiovasc Res. 2006 Jul 15;71(2):374-82
references.pmid: 16780821
references.citation: J Cell Physiol. 2001 Sep;188(3):281-90
references.pmid: 11473354
references.citation: Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H112-8
references.pmid: 19855060
references.citation: Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2614-21
references.pmid: 17023676
references.citation: Exp Cell Res. 2003 Mar 10;284(1):14-30
references.pmid: 12648463
references.citation: J Am Coll Cardiol. 2006 Feb 21;47(4):817-26
references.pmid: 16487851
references.citation: J Biol Chem. 2006 Jul 14;281(28):19469-77
references.pmid: 16698793
references.citation: Cardiovasc Res. 2012 May 1;94(2):304-15
references.pmid: 22227153
references.citation: Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H72-3
references.pmid: 16373594
references.citation: Nat Cell Biol. 2001 Oct;3(10):867-73
references.pmid: 11584267
references.citation: J Clin Invest. 2005 May;115(5):1221-31
references.pmid: 15841206
references.citation: J Biol Chem. 2004 Dec 10;279(50):52095-105
references.pmid: 15466415
references.citation: Nat Rev Mol Cell Biol. 2005 Feb;6(2):150-66
references.pmid: 15688001
references.citation: Mol Cell Biochem. 2003 Nov;253(1-2):113-23
references.pmid: 14619961
references.citation: Life Sci. 2008 Aug 15;83(7-8):264-71
references.pmid: 18625248
references.citation: Circ Res. 1998 Feb 9;82(2):195-203
references.pmid: 9468190
references.citation: Am J Physiol. 1997 Jan;272(1 Pt 2):H350-9
references.pmid: 9038956
references.citation: J Biol Chem. 2001 Oct 12;276(41):38121-38
references.pmid: 11457855
references.citation: Circulation. 2001 Sep 11;104(11):1286-91
references.pmid: 11551881
references.citation: Neuron. 1997 Jun;18(6):847-55
references.pmid: 9208852
references.citation: Circ Res. 1991 Jan;68(1):269-79
references.pmid: 1845855
references.citation: J Biol Chem. 1998 Dec 25;273(52):34724-9
references.pmid: 9856995
references.citation: J Biol Chem. 1997 Oct 10;272(41):25907-12
references.pmid: 9325323
references.citation: Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8880-5
references.pmid: 12072561
references.citation: J Mol Med (Berl). 2006 Nov;84(11):975-83
references.pmid: 16924465
references.citation: Semin Oncol. 2002 Jun;29(3 Suppl 11):22-8
references.pmid: 12138394
references.citation: Nature. 2002 Mar 21;416(6878):337-9
references.pmid: 11907582
references.citation: J Cell Physiol. 2003 Nov;197(2):284-96
references.pmid: 14502568
references.citation: Cardiovasc Res. 2007 Jul 15;75(2):315-26
references.pmid: 17568574
references.citation: Nat Rev Mol Cell Biol. 2007 Oct;8(10):813-24
references.pmid: 17848967
references.citation: J Cardiovasc Pharmacol. 1985 Sep-Oct;7(5):971-6
references.pmid: 2413310
references.citation: Anesthesiology. 1993 Dec;79(6):1354-66
references.pmid: 8267211
references.citation: Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H49-55
references.pmid: 12485816
references.citation: J Cell Physiol. 2008 Oct;217(1):242-9
references.pmid: 18528823
references.citation: J Physiol. 2002 Apr 15;540(Pt 2):457-67
references.pmid: 11956336
references.citation: J Gen Physiol. 1996 Oct;108(4):277-93
references.pmid: 8894977
references.citation: J Pharmacol Exp Ther. 1992 Jun;261(3):931-5
references.pmid: 1602398
references.citation: Cardiovasc Res. 2014 May 1;102(2):194-204
references.pmid: 24477642
references.citation: Am J Physiol Regul Integr Comp Physiol. 2003 Jan;284(1):R1-12
references.pmid: 12482742
references.citation: Physiol Rev. 2007 Jan;87(1):315-424
references.pmid: 17237348
references.citation: J Appl Physiol (1985). 2011 Aug;111(2):566-72
references.pmid: 21596922
references.citation: Front Physiol. 2012 Jan 06;2:120
references.pmid: 22232608
references.citation: Br J Pharmacol. 2008 Mar;153(6):1105-19
references.pmid: 17965745
references.citation: Am J Physiol. 1993 Jul;265(1 Pt 2):H176-82
references.pmid: 8342632
references.citation: Pharmacol Ther. 2006 Aug;111(2):508-31
references.pmid: 16457892
references.citation: Biochem J. 2005 Feb 1;385(Pt 3):769-77
references.pmid: 15377279
references.citation: Hypertension. 2006 Apr;47(4):727-34
references.pmid: 16505203
references.citation: Cardiovasc Res. 2005 Jun 1;66(3):444-53
references.pmid: 15914109
references.citation: J Mol Cell Cardiol. 2011 May;50(5):884-93
references.pmid: 21320508
references.citation: News Physiol Sci. 1999 Dec;14:243-249
references.pmid: 11390859
references.citation: Circ Res. 2002 May 3;90(8):838-41
references.pmid: 11988482
references.citation: Annu Rev Pharmacol Toxicol. 2004;44:195-217
references.pmid: 14744244
references.citation: J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S397-400
references.pmid: 11078432
references.citation: Circ Res. 1991 Sep;69(3):582-9
references.pmid: 1873860
references.citation: Cardiovasc Res. 1999 Oct;44(1):47-59
references.pmid: 10615389