title: Epilepsy treatment by sacrificing vitamin D.
abstract: Epilepsy is one of the most common neurologic disorders in childhood that often requires long term treatment with antiepileptic drugs. Both antiepileptic treatment and the comorbidities associated with epilepsy have a negative impact on bone health in growing children. Given the fact that vitamin D deficiency is a major public health problem worldwide, clinicians caring for children with chronic diseases should be aware of effects of the medication on the bone metabolism. Yet, vitamin D deficiency due to antiepileptic treatment is an overlooked issue among neurologists. In this review, we briefly describe vitamin D metabolism and the effect of vitamin D in the brain. We also discuss the literature in terms of vitamin D deficiency and antiepileptic treatment in the pediatric population.
authors.affiliation: Derince Training and Research Hospital, Pediatric Endocrinology Clinic, Kocaeli, Turkey.
authors.forename: Ayşe Nurcan
authors.initials: AN
authors.lastname: Cebeci
authors.forename: Barış
authors.initials: B
authors.lastname: Ekici
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D014807:Vitamin D / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000139:chemically induced*
chemical_list: D000927:Anticonvulsants; D014807:Vitamin D