title: Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency.
abstract: OBJECTIVE
  GH therapy is still controversial, except in severe GH deficiency (SGHD). The objective of this study was to compare the response to growth hormone (GH) therapy in children with partial GH insensitivity (PGHIS) and mild GH deficiency (MGHD) with those with SGHD.
  
  
  METHODS
  Fifteen PGHIS, 11 MGHD, and 19 SGHD subjects, followed up for more than one year in the Brazilian public care service, were evaluated regarding anthropometric and laboratory data at the beginning of treatment, after one year (1st year) on treatment, and at the last assessment (up to ten years in SGHD, up to four years in MGHD, and up to eight years in PGHIS).
  
  
  RESULTS
  Initial height standard deviation score (SDS) in SGHD was lower than in MGHD and PGHIS. Although the increase in 1 st year height SDS in comparison to initial height SDS was not different among the groups, height-SDS after the first year of treatment remained lower in SGHD than in MGHD. There was no difference in height-SDS at the last assessment of the children among the three groups. GH therapy, in the entire period of observation, caused a trend towards lower increase in height SDS in PGHIS than SGHD but similar increases were observed in MGHD and SGHD.
  
  
  CONCLUSIONS
  GH therapy increases height in PGHIS and produces similar height effects in MGHD and SGHD.
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Daniela F
authors.initials: DF
authors.lastname: Cardoso
authors.affiliation: Department of Pediatrics, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
authors.forename: Carlos Eduardo
authors.initials: CE
authors.lastname: Martinelli
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Viviane C
authors.initials: VC
authors.lastname: Campos
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Elenilde S
authors.initials: ES
authors.lastname: Gomes
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Ivina E S
authors.initials: IE
authors.lastname: Rocha
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Carla R P
authors.initials: CR
authors.lastname: Oliveira
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Taisa A R
authors.initials: TA
authors.lastname: Vicente
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Rossana M C
authors.initials: RM
authors.lastname: Pereira
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Pereira
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Carla K A
authors.initials: CK
authors.lastname: Cartaxo
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Soraya L S
authors.initials: SL
authors.lastname: Milani
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Mario C P
authors.initials: MC
authors.lastname: Oliveira
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Enaldo V
authors.initials: EV
authors.lastname: Melo
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Andre L P
authors.initials: AL
authors.lastname: Oliveira
authors.affiliation: Department of Medicine, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Manuel H
authors.initials: MH
authors.lastname: Aguiar-Oliveira
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D000704:Analysis of Variance; D001827:Body Height / Q000187:drug effects; D015992:Body Mass Index; D001938:Brazil; D002648:Child; D019382:Human Growth Hormone / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D046150:Laron Syndrome / Q000188:drug therapy*; D008163:Luminescent Measurements; D011994:Recombinant Proteins / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I