title: Spatial and Temporal EEG-fMRI Changes During Preictal and Postictal Phases in a Patient With Posttraumatic Epilepsy.
abstract: The combined use of electroencephalography (EEG) and functional magnetic resonance imaging (EEG-fMRI) in epilepsy allows the noninvasive hemodynamic characterization of epileptic discharge-related neuronal activations. The aim of this study was to investigate pathophysiologic mechanisms underlying epileptic activity by exploring the spatial and temporal distribution of fMRI signal modifications during seizure in a single patient with posttraumatic epilepsy. EEG and fMRI data were acquired during two scanning sessions: a spontaneous critical episode was observed during the first, and interictal events were recorded during the second. The EEG-fMRI data were analyzed using the general linear model (GLM). Blood oxygenation level-dependent (BOLD) localization derived from the preictal and artifact-free postictal phase was concordant with the BOLD localization of the interictal epileptiform discharges identified in the second session, pointing to a left perilesional mesiofrontal area. Of note, BOLD signal modifications were already visible several seconds before seizure onset. In brief, BOLD activations from the preictal, postictal, and interictal epileptiform discharge analysis appear to be concordant with the clinically driven localization hypothesis, whereas a widespread network of activations is detected during the ictal phase in a partial seizure.
authors.affiliation: Department of Neurological and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy silviafrancesca.storti@univr.it.
authors.forename: Silvia F
authors.initials: SF
authors.lastname: Storti
authors.affiliation: Department of Neurological and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Del Felice
authors.affiliation: Department of Neurophysiology, Foundation IRCCS San Camillo Hospital, Venice, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Formaggio
authors.affiliation: Department of Neurological and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Boscolo Galazzo
authors.affiliation: Department of Neurological and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy.
authors.forename: Luigi G
authors.initials: LG
authors.lastname: Bongiovanni
authors.affiliation: Department of Pathology and Diagnostics, University of Verona, Verona, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cerini
authors.affiliation: Department of Neurological and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy Department of Neurophysiology, Foundation IRCCS San Camillo Hospital, Venice, Italy Clinical Neurophysiology and Functional Neuroimaging Unit, AOUI of Verona, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Fiaschi
authors.affiliation: Department of Neurological and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy Department of Neurophysiology, Foundation IRCCS San Camillo Hospital, Venice, Italy Clinical Neurophysiology and Functional Neuroimaging Unit, AOUI of Verona, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Manganotti
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001930:Brain Injuries / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D062211:Spatio-Temporal Analysis
keywords: BOLD signal; ictal and postictal EEG-fMRI; interictal EEG-fMRI; posttraumatic epilepsy; seizure spread