title: The integrative role of the sigh in psychology, physiology, pathology, and neurobiology.
abstract: "Sighs, tears, grief, distress" expresses Johann Sebastian Bach in a musical example for the relationship between sighs and deep emotions. This review explores the neurobiological basis of the sigh and its relationship with psychology, physiology, and pathology. Sighs monitor changes in brain states, induce arousal, and reset breathing variability. These behavioral roles homeostatically regulate breathing stability under physiological and pathological conditions. Sighs evoked in hypoxia evoke arousal and thereby become critical for survival. Hypoarousal and failure to sigh have been associated with sudden infant death syndrome. Increased breathing irregularity may provoke excessive sighing and hyperarousal, a behavioral sequence that may play a role in panic disorders. Essential for generating sighs and breathing is the pre-Bötzinger complex. Modulatory and synaptic interactions within this local network and between networks located in the brainstem, cerebellum, cortex, hypothalamus, amygdala, and the periaqueductal gray may govern the relationships between physiology, psychology, and pathology. Unraveling these circuits will lead to a better understanding of how we balance emotions and how emotions become pathological.
authors.affiliation: Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Neurological Surgery, University of Washington, Seattle, WA, USA. Electronic address: nino1@uw.edu.
authors.forename: Jan-Marino
authors.initials: JM
authors.lastname: Ramirez
mesh_terms: D001143:Arousal / Q000502:physiology; D004644:Emotions / Q000502:physiology; D006801:Humans; D012119:Respiration; D012125:Respiratory Center / Q000502:physiology*
keywords: PAG; SIDS; anxiety; arousal; breathing; cardiorespiratory; panic; pre-Bötzinger complex; rhythm generation
references.citation: Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12236-41
references.pmid: 16099832
references.citation: J Neurophysiol. 2006 Mar;95(3):1334-44
references.pmid: 16492945
references.citation: Chest. 2005 Oct;128(4):2478-84
references.pmid: 16236912
references.citation: Braz J Psychiatry. 2013 Mar;35(1):57-62
references.pmid: 23567601
references.citation: Physiol Behav. 2013 Sep 10;121:117-24
references.pmid: 23562864
references.citation: J Neurophysiol. 1999 Nov;82(5):2163-70
references.pmid: 10561396
references.citation: Dev Psychobiol. 2011 Dec;53(8):785-95
references.pmid: 21547900
references.citation: Pediatr Res. 1998 Nov;44(5):767-73
references.pmid: 9803460
references.citation: Am J Respir Crit Care Med. 2001 Oct 15;164(8 Pt 1):1464-9
references.pmid: 11704597
references.citation: Science. 1978 Apr 28;200(4340):453-6
references.pmid: 644309
references.citation: PLoS Comput Biol. 2010 Jul 01;6(7):e1000838
references.pmid: 20628472
references.citation: Sleep Med. 2010 Aug;11(7):603-14
references.pmid: 20630799
references.citation: Cereb Cortex. 1991 Sep-Oct;1(5):418-25
references.pmid: 1822749
references.citation: J Psychosom Res. 2013 Apr;74(4):283-9
references.pmid: 23497828
references.citation: J Appl Physiol. 1964 Mar;19:195-8
references.pmid: 14155280
references.citation: Ann N Y Acad Sci. 2010 Jun;1198:72-84
references.pmid: 20536922
references.citation: Sleep Med. 2002 Dec;3 Suppl 2:S37-40
references.pmid: 14592377
references.citation: J Exp Biol. 2012 Sep 1;215(Pt 17):3028-36
references.pmid: 22660774
references.citation: Sleep. 2006 Jun;29(6):785-90
references.pmid: 16796217
references.citation: J Neurophysiol. 2013 Oct;110(8):1903-14
references.pmid: 23883859
references.citation: Curr Opin Neurobiol. 2002 Dec;12(6):646-51
references.pmid: 12490254
references.citation: J Speech Lang Hear Res. 2011 Feb;54(1):33-46
references.pmid: 20844256
references.citation: Nat Neurosci. 2008 May;11(5):538-40
references.pmid: 18391943
references.citation: Anxiety. 1996;2(3):145-8
references.pmid: 9160616
references.citation: Sleep. 2010 Mar;33(3):379-87
references.pmid: 20337197
references.citation: J Neurosci. 2010 Nov 3;30(44):14883-95
references.pmid: 21048147
references.citation: Trends Cardiovasc Med. 2011 Nov;21(8):216-20
references.pmid: 22902068
references.citation: Respir Physiol Neurobiol. 2009 May 30;167(1):133-43
references.pmid: 18707030
references.citation: Respir Physiol Neurobiol. 2013 Nov 1;189(2):315-23
references.pmid: 23707877
references.citation: Psychosom Med. 2001 Jul-Aug;63(4):638-49
references.pmid: 11485118
references.citation: J Fam Pract. 2008 Jan;57(1):E1-5
references.pmid: 18171560
references.citation: J Clin Psychiatry. 2013 Mar;74(3):e197-204
references.pmid: 23561240
references.citation: J Physiol. 1923 Oct 22;58(1):81-91
references.pmid: 16993631
references.citation: Epilepsia. 1996 May;37(5):459-62
references.pmid: 8617175
references.citation: J Neurophysiol. 1994 Dec;72(6):2598-608
references.pmid: 7897477
references.citation: Chest. 2007 Feb;131(2):595-607
references.pmid: 17296668
references.citation: J Physiol. 1984 Feb;347:1-16
references.pmid: 6707950
references.citation: J Physiol. 2013 Jan 1;591(1):109-22
references.pmid: 23129795
references.citation: Pediatr Pulmonol. 2008 Nov;43(11):1045-1060
references.pmid: 18831533
references.citation: J Neurosci. 2004 Aug 25;24(34):7549-56
references.pmid: 15329402
references.citation: J Appl Physiol (1985). 1998 Dec;85(6):2314-21
references.pmid: 9843558
references.citation: Respir Physiol Neurobiol. 2013 Nov 1;189(2):324-8
references.pmid: 23850567
references.citation: J Appl Physiol (1985). 1993 Feb;74(2):761-9
references.pmid: 8458793
references.citation: Am J Speech Lang Pathol. 2012 Nov;21(4):368-79
references.pmid: 22846880
references.citation: J Neurophysiol. 2006 Apr;95(4):2070-82
references.pmid: 16394066
references.citation: J Exp Biol. 1983 Jul;105:59-82
references.pmid: 6619733
references.citation: J Neurosci. 2010 Jun 16;30(24):8251-62
references.pmid: 20554877
references.citation: J Comp Neurol. 2013 Sep 1;521(13):3083-98
references.pmid: 23630049
references.citation: Int J Psychophysiol. 1994 Jul;17(2):103-28
references.pmid: 7995774
references.citation: J Comput Neurosci. 2012 Aug;33(1):77-95
references.pmid: 22134522
references.citation: Respir Care. 2002 Mar;47(3):308-17; discussion 317-8
references.pmid: 11874609
references.citation: Biol Psychol. 2010 Apr;84(1):82-7
references.pmid: 19744538
references.citation: Eur Respir J. 2003 Oct;22(4):661-7
references.pmid: 14582921
references.citation: Eur Arch Psychiatry Clin Neurosci. 2011 Nov;261 Suppl 2:S172-6
references.pmid: 21901267
references.citation: Eur J Neurosci. 2012 Jul;36(2):2121-36
references.pmid: 22805058
references.citation: Anxiety. 1994;1(1):1-7
references.pmid: 9160539
references.citation: Respir Physiol Neurobiol. 2005 Nov 15;149(1-3):257-71
references.pmid: 15876558
references.citation: Philos Trans R Soc Lond B Biol Sci. 2009 Sep 12;364(1529):2577-87
references.pmid: 19651658
references.citation: Respir Physiol Neurobiol. 2005 Nov 15;149(1-3):243-55
references.pmid: 15941675
references.citation: J Neurophysiol. 2012 Jan;107(2):718-27
references.pmid: 21994267
references.citation: Epilepsy Behav. 2011 May;21(1):100-2
references.pmid: 21482194
references.citation: Pediatr Res. 2006 Oct;60(4):443-9
references.pmid: 16940240
references.citation: Biol Psychiatry. 2001 Apr 1;49(7):588-95
references.pmid: 11297716
references.citation: Respir Physiol Neurobiol. 2010 May 31;171(3):201-11
references.pmid: 20382275
references.citation: Int J Psychophysiol. 2007 Dec;66(3):169-82
references.pmid: 17706311
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1978 Jun;44(6):931-8
references.pmid: 670014
references.citation: Respir Physiol Neurobiol. 2013 Nov 1;189(2):288-300
references.pmid: 23735486
references.citation: PLoS One. 2013 May 17;8(5):e64519
references.pmid: 23691240
references.citation: Neuroscience. 2007 Jul 29;147(4):1066-75
references.pmid: 17600629
references.citation: Neurosci Res. 2011 Oct;71(2):134-9
references.pmid: 21726588
references.citation: Sci Signal. 2013 Jan 29;6(260):ra6
references.pmid: 23362239
references.citation: Sleep Med. 2003 Nov;4(6):569-77
references.pmid: 14607352
references.citation: Auton Neurosci. 2005 Dec 30;123(1-2):1-11
references.pmid: 16289941
references.citation: Biol Psychol. 1998 Sep;49(1-2):29-51
references.pmid: 9792483
references.citation: Mil Med. 2012 Jun;177(6):655-62
references.pmid: 22730840
references.citation: J Biol Phys. 2011 Jun;37(3):241-61
references.pmid: 22654176
references.citation: J Neurosci. 2007 Aug 8;27(32):8709-18
references.pmid: 17687048
references.citation: Biol Psychiatry. 1996 Feb 15;39(4):255-66
references.pmid: 8645772
references.citation: Science. 1985 Jul 5;229(4708):67-9
references.pmid: 3925552
references.citation: N Engl J Med. 1994 Jun 9;330(23):1639-44
references.pmid: 7993409
references.citation: Respir Physiol. 1972 Oct;16(2):179-96
references.pmid: 4644668
references.citation: Psychophysiology. 2009 Sep;46(5):1005-13
references.pmid: 19497009
references.citation: Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3573-8
references.pmid: 23401542
references.citation: Acta Psychiatr Scand. 1984 Feb;69(2):121-8
references.pmid: 6422704
references.citation: Depress Anxiety. 2001;14(4):232-7
references.pmid: 11754131
references.citation: J Neurophysiol. 2008 May;99(5):2114-25
references.pmid: 18287547
references.citation: Arch Gen Psychiatry. 1993 Apr;50(4):306-17
references.pmid: 8466392
references.citation: FEBS J. 2005 Nov;272(22):5689-93
references.pmid: 16279934
references.citation: J Clin Sleep Med. 2012 Dec 15;8(6):673-9
references.pmid: 23243401
references.citation: Psychiatr Clin North Am. 2013 Mar;36(1):121-40
references.pmid: 23538082
references.citation: J Neurophysiol. 2001 Jul;86(1):104-12
references.pmid: 11431492
references.citation: Respir Physiol. 1992 Jun;88(3):313-21
references.pmid: 1615228
references.citation: J Appl Physiol (1985). 1997 Jul;83(1):219-28
references.pmid: 9216967
references.citation: Respir Physiol Neurobiol. 2013 Nov 1;189(2):301-14
references.pmid: 23851109
references.citation: Stress. 2005 Dec;8(4):233-46
references.pmid: 16423712
references.citation: Neurosci Lett. 2000 Mar 31;283(1):21-4
references.pmid: 10729624
references.citation: J Neurol Neurosurg Psychiatry. 2011 Aug;82(8):928-30
references.pmid: 20562456
references.citation: Brain. 2011 Jan;134(Pt 1):24-35
references.pmid: 21115469
references.citation: Am J Respir Crit Care Med. 2011 Aug 15;184(4):474-81
references.pmid: 21616995
references.citation: Sleep. 2008 Jun;31(6):833-40
references.pmid: 18548828
references.citation: Compr Physiol. 2012 Oct;2(4):2683-731
references.pmid: 23720262
references.citation: J Neurosci. 2010 Dec 15;30(50):16970-82
references.pmid: 21159967
references.citation: Physiol Behav. 2005 Aug 7;85(5):598-602
references.pmid: 16038951
references.citation: J Neurosci. 2003 Feb 1;23(3):943-54
references.pmid: 12574423
references.citation: J Neurosci. 2009 Mar 25;29(12):3720-37
references.pmid: 19321769
references.citation: Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):1967-76
references.pmid: 8520764
references.citation: Sleep. 2005 Jun;28(6):747-52
references.pmid: 16477962
references.citation: Acta Physiol Scand. 1981 Mar;111(3):349-60
references.pmid: 6797251
references.citation: Int J Psychophysiol. 2011 Nov;82(2):175-9
references.pmid: 21872623
references.citation: Curr Opin Pediatr. 2008 Dec;20(6):654-8
references.pmid: 19005334
references.citation: Pediatrics. 1988 Nov;82(5):721-7
references.pmid: 3186351
references.citation: Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2035-40
references.pmid: 11172071
references.citation: Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:1626-9
references.pmid: 21096136
references.citation: Nat Neurosci. 2001 Sep;4(9):927-30
references.pmid: 11528424
references.citation: Neuroscience. 1988 Jun;25(3):1041-51
references.pmid: 3405423
references.citation: J Neurophysiol. 2013 Jan;109(2):296-305
references.pmid: 22993257
references.citation: Neuron. 2004 Jul 8;43(1):105-17
references.pmid: 15233921
references.citation: J Neurophysiol. 2006 Mar;95(3):1323-33
references.pmid: 16492944
references.citation: Clin Auton Res. 1998 Oct;8(5):243-9
references.pmid: 9801844
references.citation: Biol Neonate. 1993;63(3):139-46
references.pmid: 8324092
references.citation: Psychosom Med. 1996 Jul-Aug;58(4):302-13
references.pmid: 8827792
references.citation: Handb Clin Neurol. 2013;110:273-81
references.pmid: 23312647
references.citation: Vitam Horm. 2012;89:135-58
references.pmid: 22640612
references.citation: Am J Psychiatry. 1994 Jun;151(6):864-70
references.pmid: 8184995
references.citation: Prog Brain Res. 2011;188:31-50
references.pmid: 21333801
references.citation: J Clin Neurophysiol. 2010 Dec;27(6):387-97
references.pmid: 21076335
references.citation: Biol Psychol. 2013 Apr;93(1):24-32
references.pmid: 23261937
references.citation: Sleep. 1996 Jul;19(6):472-8
references.pmid: 8865504
references.citation: Neuron. 2013 Mar 20;77(6):1047-54
references.pmid: 23522041
references.citation: Prog Brain Res. 2012;198:25-46
references.pmid: 22813968
references.citation: Adv Exp Med Biol. 2000;475:801-13
references.pmid: 10849723
references.citation: Int J Pediatr. 2012;2012:843016
references.pmid: 22899942
references.citation: Depress Anxiety. 2002;16(2):51-8
references.pmid: 12219335
references.citation: Nat Neurosci. 2000 Jun;3(6):600-7
references.pmid: 10816317
references.citation: J Appl Physiol (1985). 1999 Jan;86(1):359-76
references.pmid: 9887151
references.citation: Neuropharmacology. 2013 Jul;70:35-42
references.pmid: 23321689
references.citation: Dialogues Clin Neurosci. 2011;13(3):263-78
references.pmid: 22034143
references.citation: PLoS Comput Biol. 2013;9(1):e1002857
references.pmid: 23326223
references.citation: Eur J Neurosci. 2011 Jun;33(12):2228-37
references.pmid: 21615559
references.citation: Prog Brain Res. 2010;187:137-48
references.pmid: 21111205
references.citation: Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R334-44
references.pmid: 19091914
references.citation: Respir Physiol Neurobiol. 2003 Jul 16;136(2-3):235-47
references.pmid: 12853014
references.citation: Neurosci Biobehav Rev. 2012 Jan;36(1):439-58
references.pmid: 21827785
references.citation: J Clin Neurosci. 2010 Dec;17(12):1503-5
references.pmid: 20833049
references.citation: Pediatr Res. 2001 Mar;49(3):402-6
references.pmid: 11228267
references.citation: Psychoneuroendocrinology. 2005 Nov;30(10):1050-8
references.pmid: 16005156
references.citation: Behav Modif. 2003 Oct;27(5):607-19
references.pmid: 14531157
references.citation: J ECT. 2010 Sep;26(3):202-7
references.pmid: 20562640
references.citation: J Clin Invest. 1960 Apr;39:573-83
references.pmid: 13807830
references.citation: J Appl Physiol (1985). 2011 Nov;111(5):1296-303
references.pmid: 21868678
references.citation: Front Hum Neurosci. 2013 Apr 18;7:146
references.pmid: 23616759
references.citation: Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2029-34
references.pmid: 11172070
references.citation: Prog Brain Res. 1996;107:327-42
references.pmid: 8782529
references.citation: Sleep. 1992 Aug;15(4):287-92
references.pmid: 1519001
references.citation: Behav Res Ther. 2013 Mar;51(3):161-6
references.pmid: 23353579
references.citation: Alcohol. 2012 Jun;46(4):329-37
references.pmid: 22560367
references.citation: Brain Res. 1991 May 24;549(2):332-7
references.pmid: 1884227
references.citation: J Clin Invest. 1960 Jan;39:143-9
references.pmid: 13822504
references.citation: Brain Res. 1991 Aug 23;557(1-2):241-54
references.pmid: 1720995
references.citation: Am J Psychiatry. 1994 Apr;151(4):547-53
references.pmid: 8147452
references.citation: Depress Anxiety. 2000;12 Suppl 1:2-19
references.pmid: 11098410
references.citation: Sleep. 1996 Dec;19(10 Suppl):S271-3
references.pmid: 9085529
references.citation: Pediatr Pulmonol. 2008 Mar;43(3):251-60
references.pmid: 18220270
references.citation: Physiol Behav. 2010 Aug 4;101(1):67-73
references.pmid: 20417649
references.citation: J Am Acad Child Adolesc Psychiatry. 2013 Feb;52(2):163-171.e2
references.pmid: 23357443
references.citation: Psychophysiology. 2011 Jan;48(1):117-20
references.pmid: 20536901
references.citation: J Neurosci. 2013 Feb 20;33(8):3633-45
references.pmid: 23426690
references.citation: Compr Physiol. 2012 Jul;2(3):2255-79
references.pmid: 23723037
references.citation: Respir Physiol. 1988 May;72(2):131-49
references.pmid: 3131860
references.citation: Curr Biol. 2008 Jun 3;18(11):R457-60
references.pmid: 18522811
references.citation: Curr Opin Neurobiol. 2004 Dec;14(6):665-74
references.pmid: 15582367
references.citation: J Appl Physiol. 1976 Oct;41(4):502-7
references.pmid: 985392
references.citation: Curr Top Med Chem. 2007;7(17):1645-59
references.pmid: 17979774
references.citation: Physiol Behav. 2013 Mar 15;112-113:23-31
references.pmid: 23403037
references.citation: J Physiol. 1919 May 20;52(6):433-53
references.pmid: 16993408
references.citation: Neural Plast. 2009;2009:108135
references.pmid: 19283082
references.citation: J ECT. 2002 Sep;18(3):118-25
references.pmid: 12394529
references.citation: J Physiol. 1998 Mar 15;507 ( Pt 3):895-907
references.pmid: 9508848
references.citation: Neurosci Biobehav Rev. 2001 Dec;25(7-8):647-59
references.pmid: 11801290
references.citation: J Pediatr. 1982 Dec;101(6):911-7
references.pmid: 7143167
references.citation: J Comp Neurol. 1989 Jun 8;284(2):242-52
references.pmid: 2754035
references.citation: Intensive Care Med. 2011 Jul;37(7):1095-102
references.pmid: 21567113
references.citation: Forensic Sci Int. 2005 May 10;149(2-3):205-17
references.pmid: 15749363
references.citation: Psychiatry Res. 2012 Aug-Sep;203(2-3):159-65
references.pmid: 22944369
references.citation: Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:195-8
references.pmid: 23365865
references.citation: Int J Psychophysiol. 2013 Feb;87(2):147-51
references.pmid: 23266658
references.citation: Biol Neonate. 1998;74(1):16-21
references.pmid: 9657665
references.citation: Science. 1991 Nov 1;254(5032):726-9
references.pmid: 1683005
references.citation: Respir Physiol Neurobiol. 2006 Aug;153(1):54-65
references.pmid: 16303337
references.citation: Sleep. 1983;6(3):234-43
references.pmid: 6622880
references.citation: J Neurosci. 2008 Nov 19;28(47):12274-83
references.pmid: 19020021
references.citation: J Neurosci. 2012 Sep 26;32(39):13380-8
references.pmid: 23015428
references.citation: J Neurol Sci. 2011 Nov 15;310(1-2):231-6
references.pmid: 21849174
references.citation: Behav Modif. 2001 Sep;25(4):513-45
references.pmid: 11530714
references.citation: Trends Neurosci. 1990 Jan;13(1):21-9
references.pmid: 1688671
references.citation: Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):707-14
references.pmid: 8118640
references.citation: J Neurosci. 2002 Dec 15;22(24):11055-64
references.pmid: 12486201
references.citation: Integr Comp Biol. 2011 Dec;51(6):856-68
references.pmid: 21856733
references.citation: Biol Psychol. 2007 Feb;74(2):174-84
references.pmid: 17045726
references.citation: J Neurophysiol. 1991 Nov;66(5):1522-37
references.pmid: 1765792
references.citation: Clin Exp Pharmacol Physiol. 2000 Dec;27(12):1022-7
references.pmid: 11117224
references.citation: Am J Respir Crit Care Med. 1995 Sep;152(3):1016-21
references.pmid: 7663777
references.citation: Respir Physiol. 1971 Jun;12(2):230-8
references.pmid: 5568463
references.citation: Adv Exp Med Biol. 2010;669:333-6
references.pmid: 20217377
references.citation: J Psychopharmacol. 2011 Jan;25(1):3-16
references.pmid: 20530586
references.citation: J Clin Psychiatry. 2013 Aug;74(8):786-92
references.pmid: 23541163
references.citation: N Engl J Med. 1991 Jun 27;324(26):1858-64
references.pmid: 2041551
references.citation: Depress Anxiety. 2008;25(10):885-7
references.pmid: 17557312
references.citation: Int J Physiol Pathophysiol Pharmacol. 2012;4(1):28-35
references.pmid: 22461954
references.citation: Cereb Cortex. 2009 Dec;19(12):2810-26
references.pmid: 19351905
references.citation: Physiol Behav. 2012 Dec 5;107(5):733-42
references.pmid: 22554617
references.citation: J Neurosci. 2009 Mar 25;29(12):3824-32
references.pmid: 19321779
references.citation: Sleep. 1979 Summer;1(4):393-412
references.pmid: 504878
references.citation: Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1004-8
references.pmid: 10988121
references.citation: Adv Exp Med Biol. 2008;605:274-8
references.pmid: 18085285
references.citation: J Neurophysiol. 1993 Nov;70(5):2148-60
references.pmid: 8294976
references.citation: Pediatrics. 1992 May;89(5 Pt 1):865-70
references.pmid: 1579396
references.citation: J Neurophysiol. 2008 Apr;99(4):1871-83
references.pmid: 18256169
references.citation: Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):96-104
references.pmid: 18602029
references.citation: Sleep. 1997 Aug;20(8):654-75
references.pmid: 9351134
references.citation: Neurosci Lett. 2012 Jul 19;521(2):98-103
references.pmid: 22668857
references.citation: Adv Exp Med Biol. 2010;669:185-8
references.pmid: 20217346
references.citation: Depress Anxiety. 2010 Apr;27(4):339-50
references.pmid: 19960531
references.citation: Int Psychogeriatr. 2013 Jun;25(6):1007-12
references.pmid: 23433477
references.citation: Ir Med J. 1992 Mar;85(1):19-22
references.pmid: 1568841
references.citation: Physiol Rev. 2007 Jul;87(3):873-904
references.pmid: 17615391
references.citation: Prog Brain Res. 2012;198:133-61
references.pmid: 22813973
references.citation: Respir Physiol Neurobiol. 2013 Nov 1;189(2):272-9
references.pmid: 23692929
references.citation: Parkinsons Dis. 2011;2011:238956
references.pmid: 21860777
references.citation: J Pediatr. 1993 Nov;123(5):686-92
references.pmid: 8229475
references.citation: Stress. 2007 Aug;10(3):221-6
references.pmid: 17613937
references.citation: J Neurophysiol. 2002 Nov;88(5):2242-50
references.pmid: 12424266
references.citation: J Trauma Stress. 2012 Dec;25(6):641-8
references.pmid: 23184401
references.citation: Respir Physiol Neurobiol. 2013 Nov 1;189(2):344-53
references.pmid: 23770311
references.citation: J Neurosci. 1994 Nov;14(11 Pt 1):6500-10
references.pmid: 7965054
references.citation: Neuroreport. 2013 Mar 27;24(5):233-40
references.pmid: 23399993
references.citation: Pediatr Pulmonol. 2012 Jul;47(7):682-91
references.pmid: 22170819
references.citation: Scand J Psychol. 2008 Feb;49(1):49-57
references.pmid: 18190402
references.citation: J Neurophysiol. 2011 Feb;105(2):625-39
references.pmid: 21084689
references.citation: Sleep Med Rev. 2013 Feb;17(1):65-74
references.pmid: 22750224
references.citation: Expert Rev Neurother. 2010 Dec;10(12):1869-86
references.pmid: 21091317
references.citation: Arch Dis Child. 1993 Aug;69(2):187-90
references.pmid: 8215518
references.citation: Braz J Psychiatry. 2012 Jun;34 Suppl 1:S32-41
references.pmid: 22729448
references.citation: Sleep Breath. 2014 Mar;18(1):111-7
references.pmid: 23657667
references.citation: Behav Modif. 2001 Sep;25(4):584-605
references.pmid: 11530717
references.citation: J Chem Neuroanat. 2013 Sep;52:9-19
references.pmid: 23651691
references.citation: Neuroscience. 2007 Jan 5;144(1):387-94
references.pmid: 17074446
references.citation: J Mol Neurosci. 2010 Jan;40(1-2):47-55
references.pmid: 19711202
references.citation: Clin EEG Neurosci. 2011 Jan;42(1):29-39
references.pmid: 21309440
references.citation: Neuroimage. 2007 May 15;36(1):131-43
references.pmid: 17428683
references.citation: Biol Psychiatry. 2001 Apr 1;49(7):596-605
references.pmid: 11297717
references.citation: Prog Cardiovasc Dis. 2013 May-Jun;55(6):548-56
references.pmid: 23621964
references.citation: PLoS One. 2011 Jan 28;6(1):e16297
references.pmid: 21297985
references.citation: Respir Physiol Neurobiol. 2013 Nov 1;189(2):280-7
references.pmid: 23816600
references.citation: J Neurophysiol. 2005 Jul;94(1):590-604
references.pmid: 15728775
references.citation: J Neurophysiol. 2013 Jan;109(2):285-95
references.pmid: 23076109
references.citation: J Physiol. 2011 May 15;589(Pt 10):2497-514
references.pmid: 21486760
references.citation: J Pediatr. 1993 Jun;122(6):874-80
references.pmid: 8501562
references.citation: Annu Rev Pathol. 2009;4:517-50
references.pmid: 19400695
references.citation: Am Rev Respir Dis. 1990 Aug;142(2):295-300
references.pmid: 2382892
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):603-12
references.pmid: 17765379
references.citation: J Clin Neurophysiol. 2010 Dec;27(6):398-405
references.pmid: 21076319