title: [Neuropad test for sudomotor function to predict the risk of diabetic foot ulceration].
abstract: OBJECTIVE
  To assess the predictive value of Neuropad test on occurrence of diabetic foot ulceration (DFU) among type 2 diabetic patients.
  
  
  METHODS
  We divided 725 cases of type 2 diabetic patients into the high-risk and the non-high-risk groups of DFU based on the results of vibration perception thresholds(VPT) examination, which was widely used as a criteria for predicting DFU. Receiver operating characteristic (ROC) analysis was used to compare the effectiveness of Neuropad with 10 g Semmes-Weinstein monofilament (10 g SWMF) testing in predicting the risk of DFU.
  
  
  RESULTS
  Among 725 patients of type 2 diabetes, 6.1% were at a high risk of DFU. Compared to non-high-risk group, patients in high-risk group had older age, longer diabetes duration, higher values of complete colour change time (CCC time) of Neuropad and higher abnormal rate of 10 g SWMF (P<0.01). CCC time of Neuropad was shown to be better in predicting the risk of DFU than 10 g SWMF, and the area under the ROC curve was about 0.8, and the best cut-off value was 22.25 min.
  
  
  CONCLUSIONS
  Neuropad is an effective means for predicting of the risk of DFU, and can be used to prevent diabetic foot ulceration.
authors.affiliation: Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail: 738307848@qq.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Qin
authors.forename: Ying
authors.initials: Y
authors.lastname: Cao
authors.forename: Fang
authors.initials: F
authors.lastname: Gao
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Luo
authors.forename: Jimin
authors.initials: J
authors.lastname: Li
authors.forename: Xiajun
authors.initials: X
authors.lastname: Fu
authors.forename: Yaoming
authors.initials: Y
authors.lastname: Xue
mesh_terms: D000328:Adult; D000368:Aged; D017719:Diabetic Foot / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000379:methods*; D011237:Predictive Value of Tests; D018570:Risk Assessment