title: Synthesis and in vitro localization study of curcumin-loaded SPIONs in a micro capillary for simulating a targeted drug delivery system.
abstract: Nano-sized curcumin-loaded super-paramagnetic iron oxide nanoparticles (CUR-OA-SPIONs) were synthesized chemically by co-precipitation method using oleic acid as a stabilizer and Myrj 52 as a surfactant. The synthesized nanoparticles were characterized for their shape, size, surface morphology, electrokinetic potential, magnetic properties, crystalinity, chemical interactions and thermal transitions. The synthesized CUR-OA-SPIONs were spherical, mono-dispersed, physically stable and super-paramagnetic in nature. In vitro localization study and aggregation dynamics of CUR-OA-SPIONs were studied with a flow of blood inside a square glass capillary (500×500 μm(2) cross section) in the presence of an externally applied magnetic field (Ms=1200 mT). This research which is first of its kind showed the fluorescent imaging of CUR-OA-SPIONs with respect to time to understand the aggregation dynamics of magnetic nanoparticles in a micro capillary simulating the case of targeted drug delivery system. The size of the aggregation increases with respect to time (t=0(+)s to t=500 s), while no significant change in the size of the aggregate was observed after time t=500 s.
authors.affiliation: Nanoformulation Research Lab, Faculty of Pharmacy, Hamdard University, New Delhi, India. Electronic address: md.anwar2008@gmail.com.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Anwar
authors.affiliation: Department of Mechanical Engineering, IIT Kanpur, Uttar Pradesh, India.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Asfer
authors.affiliation: Department of Mechanical Engineering, IIT Kanpur, Uttar Pradesh, India.
authors.forename: Ayodhya P
authors.initials: AP
authors.lastname: Prajapati
authors.affiliation: Nanoformulation Research Lab, Faculty of Pharmacy, Hamdard University, New Delhi, India.
authors.forename: Sharmistha
authors.initials: S
authors.lastname: Mohapatra
authors.affiliation: Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, Utrecht 3584 CG, The Netherlands.
authors.forename: Sohail
authors.initials: S
authors.lastname: Akhter
authors.affiliation: Nanoformulation Research Lab, Faculty of Pharmacy, Hamdard University, New Delhi, India.
authors.forename: Asgar
authors.initials: A
authors.lastname: Ali
authors.affiliation: Nanoformulation Research Lab, Faculty of Pharmacy, Hamdard University, New Delhi, India. Electronic address: farhanja_2000@yahoo.com.
authors.forename: Farhan J
authors.initials: FJ
authors.lastname: Ahmad
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D011232:Chemical Precipitation; D002626:Chemistry, Pharmaceutical; D003474:Curcumin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D004337:Drug Carriers; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D008280:Magnetics / Q000295:instrumentation; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D036103:Nanotechnology; D019301:Oleic Acid / Q000737:chemistry; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D013997:Time Factors
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D005079:Excipients; D058185:Magnetite Nanoparticles; D013501:Surface-Active Agents; C526284:polyoxyethylene 40 stearate; D019301:Oleic Acid; D011092:Polyethylene Glycols; D003474:Curcumin
keywords: Curcumin; Drug localization; Drug targeting; Imaging; SPIONs; Superparamagnetic iron oxide nanoparticles