title: Hemodynamic changes during posterior epilepsies: an EEG-fNIRS study.
abstract: Posterior epilepsies are mainly characterized clinically by visual symptoms. Functional near-infrared spectroscopy (fNIRS) is an emerging non-invasive imaging technique that has the potential to monitor hemodynamic changes during epileptic activity. Combined with electroencephalography (EEG), 9 patients with posterior epilepsies were recorded using EEG-fNIRS with large sampling (19 EEG electrodes and over 100 fNIRS channels). Spikes and seizures were carefully marked on EEG traces, and convolved with a standard hemodynamic response function for general linear model (GLM) analysis. GLM results for seizures (in 3 patients) and spikes (7 patients) were broadly sensitive to the epileptic focus in 7/9 patients, and specific in 5/9 patients with fNIRS deoxyhemoglobin responses lateralized to the correct lobe, and to plausible locations within the occipital or parietal lobes. This work provides evidence that EEG-fNIRS is a sensitive technique for monitoring posterior epileptic activity.
authors.affiliation: Département de génie électrique, École Polytechnique de Montréal, C.P. 6079, Succ. Centre-ville, Montréal, QC, Canada H3C3A7; Institut de cardiologie de Montréal, Centre de recherche, 5000 Rue Bélanger Est, Montréal, QC, Canada H1T1C8. Electronic address: ph.pouliot@gmail.com.
authors.forename: Philippe
authors.initials: P
authors.lastname: Pouliot
authors.affiliation: Service de neurologie, Hôpital Notre-Dame du CHUM, 1560 Rue Sherbrooke Est, Montréal, QC, Canada H3L4M1.
authors.forename: Thi Phuoc Yen
authors.initials: TP
authors.lastname: Tran
authors.affiliation: Service de neurologie, Hôpital Notre-Dame du CHUM, 1560 Rue Sherbrooke Est, Montréal, QC, Canada H3L4M1.
authors.forename: Véronica
authors.initials: V
authors.lastname: Birca
authors.affiliation: Centre de recherche, Hôpital Sainte-Justine, 3175 Chemin de la côte-Sainte-Catherine, Montréal, QC, Canada H3T1C5.
authors.forename: Phetsamone
authors.initials: P
authors.lastname: Vannasing
authors.affiliation: Centre de recherche, Hôpital Sainte-Justine, 3175 Chemin de la côte-Sainte-Catherine, Montréal, QC, Canada H3T1C5.
authors.forename: Julie
authors.initials: J
authors.lastname: Tremblay
authors.affiliation: Centre de recherche, Hôpital Sainte-Justine, 3175 Chemin de la côte-Sainte-Catherine, Montréal, QC, Canada H3T1C5; Centre de recherche en neuropsychologie et cognition, Département de psychologie, Université de Montréal, Montréal, QC, Canada H3C3J7.
authors.forename: Maryse
authors.initials: M
authors.lastname: Lassonde
authors.affiliation: Service de neurologie, Hôpital Notre-Dame du CHUM, 1560 Rue Sherbrooke Est, Montréal, QC, Canada H3L4M1.
authors.forename: Dang Khoa
authors.initials: DK
authors.lastname: Nguyen
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D004828:Epilepsies, Partial / Q000503:physiopathology; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D012640:Seizures / Q000503:physiopathology*; D012815:Signal Processing, Computer-Assisted; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D055815:Young Adult
chemical_list: D006454:Hemoglobins; C100003:deoxyhemoglobin
keywords: EEG-fNIRS; Epileptic spikes; Hemodynamic response; Occipital lobe epilepsy; Seizures