title: Idiopathic desmoid-type fibromatosis of the pancreatic head: case report and literature review.
abstract: Desmoid-type fibromatosis (DTF) is an uncommon nonmetastatic fibrous neoplasm. Sporadic intraperitoneal DTF is rarely described in current literature. We herein report a case of DTF of unknown cause involving the pancreatic head. A 41-year-old man presented with recurrent epigastric pain and weight loss. An abdominal computed tomography scan showed a well-delineated solid cystic mass inside the pancreatic head. Pylorus-preserving pancreaticoduodenectomy was performed due to the patient's debilitating symptoms and suspected malignancy. The pathological examination revealed massive fibroblastic proliferation arising from the musculoaponeurotic tissues, consistent with a diagnosis of DTF. Immunohistochemical phenotyping determined positive immunoreactivity to vimentin and β-catenin, but negative immunoreactivity to smooth muscle actin, CD117, CD34, or S-100, confirming the diagnosis of DTF. No local recurrence or distant metastasis was found during a 24-month follow-up. Radical resection is recommended as first-line treatment for pancreatic DTF. Long-term follow-up studies are required to establish the prognosis of pancreatic DTF.
authors.forename: Changjun
authors.initials: C
authors.lastname: Jia
authors.forename: Baoling
authors.initials: B
authors.lastname: Tian
authors.affiliation: Department of General Surgery, Shengjing Hospital, China Medical University, 36 Sanhao Street, Shenyang 110004, China. daicl_sj@163.com.
authors.forename: Chaoliu
authors.initials: C
authors.lastname: Dai
authors.forename: Xinlu
authors.initials: X
authors.lastname: Wang
authors.forename: Xianmin
authors.initials: X
authors.lastname: Bu
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
mesh_terms: D000328:Adult; D018222:Desmoid Tumors / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000601:surgery; D016577:Pancreaticoduodenectomy; D011379:Prognosis; D014057:Tomography, X-Ray Computed
references.citation: Pathology. 2010 Feb;42(2):147-50
references.pmid: 20085516
references.citation: Am J Surg Pathol. 2005 May;29(5):653-9
references.pmid: 15832090
references.citation: Gastroenterol Hepatol (N Y). 2010 Oct;6(10):662-5
references.pmid: 21103447
references.citation: Curr Opin Oncol. 2009 Jul;21(4):352-9
references.pmid: 19436199
references.citation: J Clin Oncol. 2007 Feb 10;25(5):501-6
references.pmid: 17290057
references.citation: Pol J Pathol. 2006;57(1):5-15
references.pmid: 16739877
references.citation: J Chin Med Assoc. 2010 Jul;73(7):393-5
references.pmid: 20688307
references.citation: Clin Cancer Res. 2011 Jun 15;17(12):4082-90
references.pmid: 21447727
references.citation: Cancer. 1980 Mar 1;45(5):954-60
references.pmid: 7260846
references.citation: Virchows Arch. 2002 Sep;441(3):308-11
references.pmid: 12242530
references.citation: Clin Transl Oncol. 2011 Mar;13(3):189-93
references.pmid: 21421464
references.citation: J Clin Gastroenterol. 2003 Aug;37(2):186-8
references.pmid: 12869894
references.citation: Cancer. 2004 Feb 1;100(3):612-20
references.pmid: 14745880
references.citation: Cancer. 2007 Jun 25;111(3):166-72
references.pmid: 17477374
references.citation: J Clin Oncol. 1995 Nov;13(11):2813-8
references.pmid: 7595743
references.citation: Dis Colon Rectum. 2005 Aug;48(8):1528-34
references.pmid: 15906134
references.citation: J Gastrointest Surg. 2006 May;10(5):679-88
references.pmid: 16773761
references.citation: Dis Colon Rectum. 2010 Mar;53(3):327-32
references.pmid: 20173481
references.citation: Fam Cancer. 2005;4(2):135-8
references.pmid: 15951964
references.citation: Ann Surg. 2012 Mar;255(3):511-6
references.pmid: 22323009
references.citation: Case Rep Oncol. 2010 Aug 06;3(2):287-93
references.pmid: 21347195
references.citation: Surg Oncol. 2007 Aug;16(2):131-42
references.pmid: 17719772
references.citation: Int J Cancer. 2011 Jul 1;129(1):256-61
references.pmid: 20830713
references.citation: Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):441-7
references.pmid: 18068311
references.citation: Case Rep Med. 2010;2010:272760
references.pmid: 20300597
references.citation: Oncologist. 2011;16(5):682-93
references.pmid: 21478276
references.citation: Expert Rev Anticancer Ther. 2009 Apr;9(4):525-35
references.pmid: 19374605
references.citation: World J Surg Oncol. 2008 Feb 08;6:17
references.pmid: 18257933
references.citation: Int J Pancreatol. 1996 Jun;19(3):197-203
references.pmid: 8807365
references.citation: JOP. 2008 May 08;9(3):339-45
references.pmid: 18469451
references.citation: Eur J Surg Oncol. 2009 Jan;35(1):3-10
references.pmid: 18722078
references.citation: J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S7-9
references.pmid: 18625396