title: [Severity of the lung disease index in infants with respiratory distress syndrome].
abstract: Optimization of respiratory support and prevention of ventilator-associate lung injure are the most important problems of neonatal resuscitation and intensive care.
  
  
  OBJECTIVE
  To improve the results of intensive care for respiratory failure in preterm infants by optimizing respiratory support on the basis of the analysis of the biomechanical characteristics of the lungs and blood gas.
  
  
  METHODS
  The study included 138 infants with birth weight 1500g (1300-1740g) and a gestational age of 30.5 (29-32) weeks in need of mechanical ventilation. Apgar score at one minute was equal to 5.0 (4.0-6.0) points, and the fifth--7.0 (6.0-7.0) points. Biomechanical properties of light investigated the dynamic lung compliance, aerodynamic upper airway resistance, the coefficient of hyperextension, the time constant and the coefficient of RVR, reflecting the patient's spontaneous breathing pattern were evaluated.
  
  
  RESULTS
  It was found that the most significant biomechanical characteristics of lungs, reflecting the severity of the respiratory failure are the dynamic compliance, aerodynamic airway resistance, coefficient C20/C, and the time constant. Correlation between the index of oxygenation, clinical assessment of the severity of respiratory failure and the duration of control mechanical ventilation was demonstrated.
  
  
  CONCLUSIONS
  Rate of hyperextension and time constant are expressed by the correlation with the level of the oxygenation index, which allows them to be used for screening evaluation of severity critically ill patients during admission to the neonatal intensive care unit.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Aleksandrovich
authors.forename: S A
authors.initials: SA
authors.lastname: Blinov
authors.forename: K V
authors.initials: KV
authors.lastname: Pshenisnov
authors.forename: E V
authors.initials: EV
authors.lastname: Parshin
mesh_terms: D001034:Apgar Score; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008168:Lung / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000097:blood; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D010100:Oxygen