title: Positive emotional arousal increases duration of memory traces: different role of dopamine D1 receptor and β-adrenoceptor activation.
abstract: We investigated the effects of post-training administration of dopamine D1 receptor antagonist SCH 23390 and β-adrenergic receptor antagonist Propranolol on memory retention of an object sampled in a state of positive emotional arousal. Saline-treated mice trained and tested under high emotional/motivational arousal (High) showed discrimination of a novel object both 24 and 96 h post-training. Instead, mice trained and tested under low motivational arousal (Low) were unable to discriminate the novel object 96 h post-training. Both a high (2 mg/kg) and a low (1 mg/kg) dose of Propranolol reduced object discrimination in High mice tested 24 h post-training, whereas neither dose was effective in Low mice. A high dose of SCH 23390 (0.025 mg/kg) reduced discrimination of the novel object in High mice tested both 24 and 96 h post-training, whereas a low dose of the D1 antagonist (0.01 mg/kg) reduced discrimination in High mice tested 96 h post-training and abolished discrimination in Low mice tested 24h after training.
authors.affiliation: Department of Psychology, Center D. Bovet, University "Sapienza", Rome, Italy; Fondazione Santa Lucia IRCCS, European Centre for Brain Research, Rome, Italy. Electronic address: david.conversi@uniroma1.it.
authors.forename: D
authors.initials: D
authors.lastname: Conversi
authors.affiliation: Department of Psychology, Center D. Bovet, University "Sapienza", Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cruciani
authors.affiliation: Department of Psychology, Center D. Bovet, University "Sapienza", Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Accoto
authors.affiliation: Department of Psychology, Center D. Bovet, University "Sapienza", Rome, Italy; Fondazione Santa Lucia IRCCS, European Centre for Brain Research, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cabib
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D017447:Receptors, Dopamine D1 / Q000502:physiology*; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology*
chemical_list: D000319:Adrenergic beta-Antagonists; D018492:Dopamine Antagonists; D011943:Receptors, Adrenergic, beta; D017447:Receptors, Dopamine D1; D011433:Propranolol
keywords: Beta-adrenoceptors; Emotional arousal; Long-term memory; Object recognition; Propranolol; SCH 23390