title: Synthesis, characterization and antioxidant activity of some new thiazolidin-4-one derivatives.
abstract: OBJECTIVE
  To design new thiazolidin-4-ones derivatives and to evaluate their potential antioxidant effects using in vitro methods.
  
  
  METHODS
  New ethyl esters of the 2-(R-phenyl)-4-oxo-thiazolidin-3-yl propionic acid were synthesized using "one step reaction" between different aromatic aldehydes, thioglycolic acid and beta-alanine ethyl ester hydrochloride. The antioxidant potential of the synthesized compounds was evaluated using the DPPH radical scavenging assay and phosphomolybdenum method.
  
  
  RESULTS
  Eight thiazolidine-4-one derivatives were obtained in good yields and high purity. The structure of the synthesized compounds was confirmed using IR spectroscopy. The evaluation of antioxidant activity showed that 2-[(4-NO2)-phenyl]-4-oxo-thiazolidin-3-yl propionic acid ethyl ester (compound 16) was the most active compound. For this derivative the DPPH radical scavenger activity (I% = 91.63% +/- 0.77) and the total antioxidant capacity (absorbance = 1.0691 +/- 0.0763) were similar with that of ascorbic acid used as standard antioxidant.
  
  
  CONCLUSIONS
  The antioxidant activity of the thiazolidine-4-one derivatives depends on the nature of the phenyl ring substituents, the NO2 and OH radicals having the most significant influence.
authors.forename: Maria
authors.initials: M
authors.lastname: Apotrosoaei
authors.forename: Ioana
authors.initials: I
authors.lastname: Vasincu
authors.forename: Sandra
authors.initials: S
authors.lastname: Constantin
authors.forename: F
authors.initials: F
authors.lastname: Buron
authors.forename: S
authors.initials: S
authors.lastname: Routier
authors.forename: Lenuta
authors.initials: L
authors.lastname: Profire
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002712:Chlorides / Q000138:chemical synthesis; D004952:Esters / Q000138:chemical synthesis; D016166:Free Radical Scavengers; D017550:Spectroscopy, Fourier Transform Infrared; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013864:Thioglycolates / Q000138:chemical synthesis; D015091:beta-Alanine / Q000138:chemical synthesis
chemical_list: D000447:Aldehydes; D000975:Antioxidants; D002712:Chlorides; D004952:Esters; D016166:Free Radical Scavengers; D053778:Thiazolidines; D013864:Thioglycolates; D015091:beta-Alanine; C017487:2-mercaptoacetate