title: Translocation t(2;7)(p11;q21) associated with the CDK6/IGK rearrangement is a rare but recurrent abnormality in B-cell lymphoproliferative malignancies.
abstract: Structural abnormalities of chromosome 7q have been regularly reported in chronic B-cell lymphoproliferative disorders. They include chromosomal translocations involving 7q21, leading to overexpression of the CDK6 gene. Three different translocations, t(7;14)(q21;q32), t(7;22)(q21;q11), and t(2;7)(p11;q21), leading to the juxtaposition of the CDK6 gene with a immunoglobulin gene enhancer during B-cell differentiation, have been described. In the past 2 years, we identified three patients with lymphoproliferative malignancy associated with a t(2;7)(p11;q21). Fluorescent in situ hybridization using an IGK probe and a library of bacterial artificial chromosome (BAC) clones located in bands 7q21.2 and 7q21.3, containing CDK6, revealed that the telomeric part of the IGK probe was translocated on the der(7) within a 51-kb region upstream of the transcriptional start site of CDK6. A total of 23 patients with indolent B-cell lymphoproliferative disorders and juxtaposition of the IG and CDK6 genes, including 20 with IGK and CDK6 juxtaposition, have been reported thus far. This rearrangement leads to the overexpression of CDK6, which encodes a cyclin-dependent protein kinase involved in cell cycle G1 phase progression and G1/S transition.
authors.affiliation: Laboratory of Histology, Embryology and Cytogenetics, Faculty of Medicine and Health Sciences, Université de Bretagne Occidentale, Brest, France; National Institute of Health and Medical Research (INSERM), Brest, France; Department of Cytogenetics and Reproductive Biology, Morvan Hospital, Brest University and Regional Hospital, Brest, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Douet-Guilbert
authors.affiliation: Department of Cytogenetics and Reproductive Biology, Morvan Hospital, Brest University and Regional Hospital, Brest, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Tous
authors.affiliation: Department of Cytogenetics and Reproductive Biology, Morvan Hospital, Brest University and Regional Hospital, Brest, France.
authors.forename: Glen
authors.initials: G
authors.lastname: Le Flahec
authors.affiliation: Laboratory of Histology, Embryology and Cytogenetics, Faculty of Medicine and Health Sciences, Université de Bretagne Occidentale, Brest, France; National Institute of Health and Medical Research (INSERM), Brest, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Bovo
authors.affiliation: Department of Cytogenetics and Reproductive Biology, Morvan Hospital, Brest University and Regional Hospital, Brest, France.
authors.forename: Marie-Josée
authors.initials: MJ
authors.lastname: Le Bris
authors.affiliation: Department of Cytogenetics and Reproductive Biology, Morvan Hospital, Brest University and Regional Hospital, Brest, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Basinko
authors.affiliation: Laboratory of Histology, Embryology and Cytogenetics, Faculty of Medicine and Health Sciences, Université de Bretagne Occidentale, Brest, France; National Institute of Health and Medical Research (INSERM), Brest, France; Department of Cytogenetics and Reproductive Biology, Morvan Hospital, Brest University and Regional Hospital, Brest, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Morel
authors.affiliation: Laboratory of Histology, Embryology and Cytogenetics, Faculty of Medicine and Health Sciences, Université de Bretagne Occidentale, Brest, France; National Institute of Health and Medical Research (INSERM), Brest, France; Department of Cytogenetics and Reproductive Biology, Morvan Hospital, Brest University and Regional Hospital, Brest, France. Electronic address: marc.debraekeleer@univ-brest.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: De Braekeleer
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D002889:Chromosomes, Human, Pair 2; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008232:Lymphoproliferative Disorders / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D014178:Translocation, Genetic
keywords: B-cell lymphoproliferative malignancy; CDK6/IGK; chromosomal abnormality; t(2;7)(p11;q21)