title: Evaluation of the implication of KIR2DL2 receptor in multiple sclerosis and herpesvirus susceptibility.
abstract: To evaluate the possible effect of cell immunoglobulin-like receptors (KIRs) on viral infection in multiple sclerosis (MS) patients, we performed genotyping of KIR2DL2 and his HLA-C1 ligand and we analyzed the presence of all eight human herpesviruses (HHVs) in 60 MS patients and 112 healthy controls. Significantly higher frequencies were found for KIR2DL2 enhanced in the presence of its ligand HLA-C1 in MS patients. Moreover, a significant association was observed between an increase in HHV risk of infection in KIR2DL2 and HLA-C1 positive patient. Our results confirm a possible effect of KIR2DL2 on viral infection susceptibility in MS patients.
authors.affiliation: Laboratory of Transmissible Diseases and Biological Active Substances, LR99-ES27, Faculty of Pharmacy, University of Monastir, Avicenne Street, 5000 Monastir, Tunisia. Electronic address: benfredj_nadia@yahoo.fr.
authors.forename: Nadia
authors.initials: N
authors.lastname: Ben Fredj
authors.affiliation: Department of Medical Sciences, Section of Microbiology, University of Ferrara, Via L. Borsari, 46, 44121 Ferrara, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Rizzo
authors.affiliation: Department of Medical Sciences, Section of Microbiology, University of Ferrara, Via L. Borsari, 46, 44121 Ferrara, Italy.
authors.forename: Daria
authors.initials: D
authors.lastname: Bortolotti
authors.affiliation: Laboratory of Transmissible Diseases and Biological Active Substances, LR99-ES27, Faculty of Pharmacy, University of Monastir, Avicenne Street, 5000 Monastir, Tunisia.
authors.forename: Faten
authors.initials: F
authors.lastname: Nefzi
authors.affiliation: Department of Neurology, Fattouma Bourguiba University Hospital, Farhat Hached Avenue, 5000 Monastir, Tunisia.
authors.forename: Saber
authors.initials: S
authors.lastname: Chebel
authors.affiliation: Department of Medical Sciences, Section of Microbiology, University of Ferrara, Via L. Borsari, 46, 44121 Ferrara, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Rotola
authors.affiliation: Department of Neurology, Fattouma Bourguiba University Hospital, Farhat Hached Avenue, 5000 Monastir, Tunisia.
authors.forename: Mahbouba
authors.initials: M
authors.lastname: Frih-Ayed
authors.affiliation: Department of Medical Sciences, Section of Microbiology, University of Ferrara, Via L. Borsari, 46, 44121 Ferrara, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Di Luca
authors.affiliation: Laboratory of Transmissible Diseases and Biological Active Substances, LR99-ES27, Faculty of Pharmacy, University of Monastir, Avicenne Street, 5000 Monastir, Tunisia.
authors.forename: Mahjoub
authors.initials: M
authors.lastname: Aouni
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics; D006561:Herpes Simplex / Q000150:complications* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000235:genetics*; D054343:Receptors, KIR2DL2 / Q000235:genetics*; D018139:Simplexvirus / Q000502:physiology; D055815:Young Adult
chemical_list: D015236:HLA-C Antigens; D054343:Receptors, KIR2DL2
keywords: Human herpesviruses; KIR2DL2; Multiple sclerosis