title: Microwave assisted synthesis of pyrido[2,3-a]carbazoles; investigation of in vitro DNA binding/cleavage, antioxidant and cytotoxicity studies.
abstract: We have developed an effective microwave assisted p-TsOH catalyzed synthesis of pyrido[2,3-a]carbazoles via a one pot reaction of ethanolamine and 1-chloro-2-formyl carbazoles. The structure has been characterized by spectroscopic methods. The electronic spectroscopic experimental evidence strongly showed that the compounds could interact with calf thymus DNA (CT-DNA) through intercalation with a binding constant value of 1.2-3.0×10(4)M(-)(1). All the compounds showed weak to moderate capacity of scavenging with DPPH. The cytotoxicity has been evaluated by MTT assay against MCF-7 cell line and compared with standard drug cisplatin.
authors.affiliation: Post-Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India.
authors.forename: Munusamy
authors.initials: M
authors.lastname: Saravanabhavan
authors.affiliation: Post-Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India.
authors.forename: Venkatesan
authors.initials: V
authors.lastname: Murugesan
authors.affiliation: Post-Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India. Electronic address: mmsekar7@gmail.com.
authors.forename: Marimuthu
authors.initials: M
authors.lastname: Sekar
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002227:Carbazoles / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects; D006801:Humans; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000633:toxicity; D061986:MCF-7 Cells; D008872:Microwaves; D056951:Photoelectron Spectroscopy
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D002227:Carbazoles; D007364:Intercalating Agents; D004247:DNA; C427203:calf thymus DNA
keywords: 1-Chloro-2-formyl carbazole; Antioxidant and cytotoxicity; DNA interaction; Ethanolamine