title: Low expression of insulin-like growth factor binding protein 7 associated with poor prognosis in human glioma.
abstract: OBJECTIVE
  To investigate insulin-like growth factor binding protein 7 (IGFBP7) mRNA levels in human glioma and normal brain tissue, and to determine their clinical significance.
  
  
  METHODS
  In this retrospective study, IGFBP7 mRNA was quantified by real-time reverse transcription-polymerase chain reaction in brain tissue samples from patients with glioma and normal control subjects. Kaplan-Meier and Cox proportional hazards analyses were performed to determine any clinical and prognostic associations.
  
  
  RESULTS
  IGFBP7 mRNA levels were significantly lower in glioma tissue (n = 120) than in normal brain tissue (n = 20). Low (i.e. below the median, 5.9) IGFBP7 mRNA levels were significantly associated with larger tumour size (≥ 5 cm, compared with <5 cm, diameter). Patients with high (above median) IGFBP7 had longer overall survival than those with low IGFBP7. Tumour grade and IGFBP7 mRNA level were independent predictors of overall survival.
  
  
  CONCLUSIONS
  IGFBP7 downregulation is associated with poor prognosis in glioma, and this molecule may represent both a prognostic marker and a potential therapeutic target.
authors.affiliation: Department of Neurosurgery, Xinxiang Central Hospital, Xinxiang, Henan, China tianxy@21cn.com.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Tian
authors.affiliation: Medical Record Library, Xinxiang Central Hospital, Xinxiang, Henan, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Xinxiang Central Hospital, Xinxiang, Henan, China.
authors.forename: Laiguang
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, Xinxiang Central Hospital, Xinxiang, Henan, China.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Neurosurgery, No. 786 Hospital of the People's Liberation Army, Nanyang, Henan, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Xie
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics* / Q000378:metabolism; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D016016:Proportional Hazards Models; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D012189:Retrospective Studies; D047368:Tumor Burden
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins; D012333:RNA, Messenger; C102529:insulin-like growth factor binding protein-related protein 1
keywords: Insulin-like growth factor binding protein 7; glioma; human; prognosis