title: Thromboembolism in inflammatory bowel disease: results from a prospective, population-based European inception cohort.
abstract: BACKGROUND
  Patients with inflammatory bowel disease (IBD) have proven an increased risk of venous thromboembolism (VTE), particularly when hospitalized. The estimate of the true risk varies considerably between studies, primarily due to differences in methodology. We set out to determine the incidence of VTE in a population-based European inception cohort.
  
  
  METHODS
  IBD patients were incepted into a cohort that was prospectively followed from the early 1990s to the early 2000s. A total of 1145 patients were followed for a total of 10,634 patient-years (p.y.).
  
  
  RESULTS
  A total of 19 thromboembolic events were identified - 13 deep vein thrombosis and 6 with pulmonary embolism. The incidence rate of VTE was 1.8 per 1000 p.y.
  
  
  CONCLUSIONS
  The risk of VTE was elevated in this IBD cohort but lower than previously reported. The highest risk was seen in hospitalized patients, but corticosteroids-requiring disease in outpatients also conferred some risk.
authors.affiliation: Department of Gastroenterology, Oslo University Hospital , Oslo , Norway.
authors.forename: Rune
authors.initials: R
authors.lastname: Isene
authors.forename: Tomm
authors.initials: T
authors.lastname: Bernklev
authors.forename: Ole
authors.initials: O
authors.lastname: Høie
authors.forename: Ebbe
authors.initials: E
authors.lastname: Langholz
authors.forename: Epameonondas
authors.initials: E
authors.lastname: Tsianos
authors.forename: Reinhold
authors.initials: R
authors.lastname: Stockbrügger
authors.forename: Selwyn
authors.initials: S
authors.lastname: Odes
authors.forename: Milada
authors.initials: M
authors.lastname: Småstuen
authors.forename: Bjørn
authors.initials: B
authors.lastname: Moum
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005060:Europe; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology*; D055815:Young Adult
keywords: Crohn’s disease; thromboembolism; ulcerative colitis