title: Management of in-stent restenosis in peripheral arteries: are DEBs sufficient as stand-alone treatment for femoro-popliteal in-stent restenosis?
abstract: The treatment of in-stent restenosis (ISR) in the femoro-popliteal artery (FPA) is one of the major challenges of endovascular therapy, occurring in up to 40% of femoro-popliteal lesions treated with bare-metal stents within 1 year of treatment. Drug-eluting technologies, involving local delivery of paclitaxel, are providing a new paradigm for the treatment of ISR. Preliminary experience shows promising results compared to other techniques such as cutting balloon angioplasty and debulking strategies. Based on available data, drug-eluting balloons (DEBs) seem sufficient as stand-alone treatment of FPA-ISR. However, larger evidence from randomized studies is warranted to identify the clinical and/or anatomical setting in which they could fail.
authors.affiliation: Division of Cardiology Department of Advanced Biomedical Sciences "Federico II" University, Naples, Italy - geko50@hotmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Franzone
authors.forename: E
authors.initials: E
authors.lastname: Stabile
authors.forename: A
authors.initials: A
authors.lastname: Carbone
authors.forename: F
authors.initials: F
authors.lastname: Scudiero
authors.forename: B
authors.initials: B
authors.lastname: Trimarco
authors.forename: G
authors.initials: G
authors.lastname: Esposito
mesh_terms: D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000295:instrumentation*; D000818:Animals; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D003251:Constriction, Pathologic; D054855:Drug-Eluting Stents; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D058426:Neointima; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D058226:Plaque, Atherosclerotic; D011150:Popliteal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D011474:Prosthesis Design; D011859:Radiography; D012008:Recurrence; D019233:Retreatment; D013997:Time Factors; D016896:Treatment Outcome; D062666:Vascular Access Devices; D014654:Vascular Patency
chemical_list: D002317:Cardiovascular Agents