title: In situ generation of sulfoxides with predetermined chirality via a structural template with a chiral-at-metal ruthenium complex.
abstract: The reaction of Δ/Λ-[Ru(bpy)2(py)2](2+) with a prochiral sulfide ligand, and then in situ oxidation, provide the corresponding Δ-[Ru(bpy)2{(R)-OSO-iPr}](+) and Λ-[Ru(bpy)2{(S)-OSO-iPr}](+) (OSO-iPr = 2-isopropylsulfonylbenzonate) enantiomers in a yield of 83% with 98% ee. The chiral sulfoxides were obtained by treatment of the sulfoxide complexes with TFA in a yield of 90% with 88-91% ee.
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. cesybh@mail.sysu.edu.cn.
authors.forename: Zheng-Zheng
authors.initials: ZZ
authors.lastname: Li
authors.forename: Su-Yang
authors.initials: SY
authors.lastname: Yao
authors.forename: Jin-Ji
authors.initials: JJ
authors.lastname: Wu
authors.forename: Bao-Hui
authors.initials: BH
authors.lastname: Ye
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism; D013454:Sulfoxides / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D013454:Sulfoxides; D012428:Ruthenium