title: Analysis of Brain Functional Changes in High-Frequency Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression.
abstract: Repetitive transcranial magnetic stimulation (rTMS) is a treatment procedure that uses magnetic fields to stimulate nerve cells in the brain, and is associated with significant improvements in clinical symptoms of major depressive disorder (MDD). The effect of rTMS treatment on the brain can be evaluated by cordance, a quantitative electroencephalography (QEEG) method that extracts information from absolute and relative power of EEG spectra. In this study, to analyze brain functional changes, pre- and post-rTMS, QEEG data were collected from 6 frontal electrodes (Fp1, Fp2, F3, F4, F7, and F8) in 2 slow bands (delta and theta) for 55 MDD subjects. To examine brain changes, cordance scores were determined, using repeated-measures analysis of variance (ANOVA). High-frequency rTMS was associated with cordance decrease in left frontal and right prefrontal regions in both delta and theta for nonresponders; it was associated with cordance increase in all right and left frontal electrodes, except F8, for responders.
authors.affiliation: Department of Computer Engineering, Faculty of Engineering and Natural Sciences, Uskudar University, Istanbul, Turkey serhat.ozekes@uskudar.edu.tr.
authors.forename: Serhat
authors.initials: S
authors.lastname: Ozekes
authors.affiliation: Department of Computer Engineering, Faculty of Engineering and Natural Sciences, Uskudar University, Istanbul, Turkey.
authors.forename: Turker
authors.initials: T
authors.lastname: Erguzel
authors.affiliation: Department of Psychiatry, NPIstanbul Hospital, Istanbul, Turkey.|Department of Psychology, Faculty of Humanities and Social Sciences, Uskudar University, Istanbul, Turkey.
authors.forename: Gokben Hizli
authors.initials: GH
authors.lastname: Sayar
authors.affiliation: Department of Psychiatry, NPIstanbul Hospital, Istanbul, Turkey.|Department of Psychology, Faculty of Humanities and Social Sciences, Uskudar University, Istanbul, Turkey.
authors.forename: Nevzat
authors.initials: N
authors.lastname: Tarhan
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003863:Depression / Q000503:physiopathology* / Q000628:therapy; D003865:Major Depressive Disorder / Q000503:physiopathology* / Q000628:therapy; D004569:Electroencephalography / Q000379:methods; D006801:Humans; D008297:Male; D017397:Prefrontal Cortex / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods
keywords: QEEG cordance; analysis of brain functional changes; major depressive disorder; repeated-measures analysis of variance; repetitive transcranial magnetic stimulation