title: Accuracy of self-reported tobacco use status among hematopoietic SCT patients.
abstract: Tobacco use is a risk factor for adverse outcomes among hematopoietic SCT (HSCT) patients. Accurate identification of tobacco use offers a vital opportunity to treat this risk factor. The current study compared self-reported tobacco use status with serum cotinine levels among HSCT patients at the time of pre-transplant evaluation. A total of 444 participants completed both assessments; 44 participants (9.9%) were classified as tobacco users with serum cotinine concentrations >2 ng/mL vs 29 with self-reporting. Sensitivity and specificity of self-reporting were 65.9% and 100%, respectively. Positive and negative predictive values were 100% and 96.4%, respectively. Comparing tobacco use documented in the medical record with cotinine, sensitivity and specificity were 51.2% and 99.2%, respectively. Factors associated with tobacco use were male gender, single relationship status, less education and younger age. In summary, utilization of serum cotinine assays increased detection of tobacco use cases >50% over self-reporting. Results are discussed in the context of translation to care, including clinical and ethical implications, and current tobacco use treatment guidelines. When cotinine assays are not available, self-reporting of any tobacco use in the year before HSCT should trigger brief advice and cessation or relapse prevention counseling.
authors.affiliation: 1] Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA [2] Behavioral Health Research Program, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Ehlers
authors.affiliation: 1] Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA [2] Behavioral Health Research Program, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Bronars
authors.affiliation: 1] Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA [2] Behavioral Health Research Program, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Patten
authors.affiliation: Behavioral Health Research Program, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: T
authors.initials: T
authors.lastname: Brockman
authors.affiliation: Behavioral Health Research Program, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: C
authors.initials: C
authors.lastname: Hughes
authors.affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Decker
authors.affiliation: Division of Epidemiology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Cerhan
authors.affiliation: Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: W
authors.initials: W
authors.lastname: Hogan
authors.affiliation: Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: A
authors.initials: A
authors.lastname: Dispenzieri
authors.affiliation: Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: S
authors.initials: S
authors.lastname: Ansell
authors.affiliation: 1] Nicotine Dependence Center Research Program, Mayo Clinic College of Medicine, Rochester, MN, USA [2] Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: J
authors.initials: J
authors.lastname: Ebbert
authors.affiliation: 1] Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN, USA [2] Human Cellular Therapy Laboratory, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: D
authors.initials: D
authors.lastname: Gastineau
mesh_terms: D003367:Cotinine / Q000097:blood; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D012307:Risk Factors; D057566:Self Report; D064424:Tobacco Use / Q000097:blood / Q000453:epidemiology*; D019172:Transplantation Conditioning / Q000379:methods; D016896:Treatment Outcome
chemical_list: D003367:Cotinine
references.citation: Nicotine Tob Res. 2009 Mar;11(3):303-7
references.pmid: 19246431
references.citation: Bone Marrow Transplant. 2012 Feb;47(2):283-90
references.pmid: 21423125
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2370-7
references.pmid: 17132767
references.citation: Hematol Oncol Stem Cell Ther. 2012;5(1):1-30
references.pmid: 22446607
references.citation: Gynecol Oncol. 2006 Dec;103(3):853-8
references.pmid: 16815535
references.citation: BMC Public Health. 2007 Mar 12;7:33
references.pmid: 17352826
references.citation: Biol Blood Marrow Transplant. 2005 Mar;11(3):223-30
references.pmid: 15744241
references.citation: Bone Marrow Transplant. 2011 Feb;46(2):285-90
references.pmid: 20479707
references.citation: J Epidemiol Community Health. 2002 Mar;56(3):167-70
references.pmid: 11854334
references.citation: Lung Cancer. 2009 Nov;66(2):218-25
references.pmid: 19321223
references.citation: Am J Transplant. 2005 May;5(5):1137-40
references.pmid: 15816897
references.citation: Bone Marrow Transplant. 2006 May;37(9):857-64
references.pmid: 16532017
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):820-2
references.pmid: 17416777
references.citation: Psychosomatics. 2010 Sep-Oct;51(5):395-400
references.pmid: 20833938
references.citation: Biol Blood Marrow Transplant. 2001;7(4):223-9
references.pmid: 11349809
references.citation: Cancer Epidemiol Biomarkers Prev. 1993 May-Jun;2(3):261-70
references.pmid: 8318879
references.citation: Biol Blood Marrow Transplant. 2010 Feb;16(2):207-14
references.pmid: 19781657
references.citation: Cancer. 2004 Aug 15;101(4):782-9
references.pmid: 15305410
references.citation: Clin Chem. 2002 Sep;48(9):1460-71
references.pmid: 12194923
references.citation: Drug Alcohol Depend. 2011 Jan 15;113(2-3):242-4
references.pmid: 20822867
references.citation: Biomarkers. 2003 May-Aug;8(3-4):218-28
references.pmid: 12944174
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1825-8
references.pmid: 17035388
references.citation: J Clin Oncol. 2005 Aug 20;23(24):5814-30
references.pmid: 16043830
references.citation: Prog Cardiovasc Nurs. 2009 Dec;24(4):119-23
references.pmid: 20002335
references.citation: Head Neck. 1999 Aug;21(5):420-7
references.pmid: 10402522
references.citation: Int J Nurs Stud. 2011 Jul;48(7):856-62
references.pmid: 21288520
references.citation: Nicotine Tob Res. 2009 Jan;11(1):12-24
references.pmid: 19246437
references.citation: Biol Blood Marrow Transplant. 2011 Jul;17(7):1004-11
references.pmid: 21453779
references.citation: Nicotine Tob Res. 2002 May;4(2):149-59
references.pmid: 12028847
references.citation: Am J Epidemiol. 2009 Jan 15;169(2):236-48
references.pmid: 19019851
references.citation: Transplant Rev (Orlando). 2008 Jul;22(3):171-7
references.pmid: 18631873
references.citation: Am J Public Health. 1993 Sep;83(9):1251-7
references.pmid: 8363000
references.citation: Nicotine Tob Res. 2003 Feb;5(1):13-25
references.pmid: 12745503
references.citation: Crit Care Med. 2011 Jan;39(1):40-5
references.pmid: 20935560
references.citation: Am J Public Health. 1992 Jan;82(1):33-6
references.pmid: 1536331