title: Dopamine transporter changes after unilateral deep brain stimulation in progressive Parkinson's disease: a case report.
abstract: Deep brain stimulation (DBS) at the subthalamic nucleus has been approved as an effective treatment for refractory symptoms of Parkinson's disease (PD). Studies have shown that bilateral DBS surgery in PD patients results in clinical improvement without reducing dopamine transporter function. Here, we report our longitudinal findings in one PD patient, ie, decreases in striatal dopamine transporter binding during one year of follow-up after unilateral DBS at the subthalamic nucleus. Based on this case, we hypothesize that clinical benefit after unilateral DBS may be not directly associated with changes in function at the subthalamic nucleus.
authors.affiliation: PET Center, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Huiwei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: PET Center, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Changhai Hospital, Shanghai, People's Republic of China.
authors.forename: Jinchuan
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Nuclear Medicine and TUM-Neuroimaging Center, Technical University Munich, Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Förster
authors.affiliation: PET Center, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.affiliation: PET Center, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: PET Center, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Yihui
authors.initials: Y
authors.lastname: Guan
authors.affiliation: PET Center, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Chuantao
authors.initials: C
authors.lastname: Zuo
keywords: Parkinson’s disease; deep brain stimulation; dopamine transporter; positron emission tomography
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