title: Control of urinary drainage and voiding.
abstract: Urine differs greatly in ion and solute composition from plasma and contains harmful and noxious substances that must be stored for hours and then eliminated when it is socially convenient to do so. The urinary tract that handles this output is composed of a series of pressurizable muscular compartments separated by sphincteric structures. With neural input, these structures coordinate the delivery, collection, and, ultimately, expulsion of urine. Despite large osmotic and chemical gradients in this waste fluid, the bladder maintains a highly impermeable surface in the face of a physically demanding biomechanical environment, which mandates recurring cycles of surface area expansion and increased wall tension during filling, followed by rapid wall compression during voiding. Afferent neuronal inflow from mucosa and submucosa communicates sensory information about bladder fullness, and voiding is initiated consciously through coordinated central and spinal efferent outflow to the detrusor, trigonal internal sphincter, and external urethral sphincter after periods of relative quiescence. Provocative new findings suggest that in some cases, lower urinary tract symptoms, such as incontinence, urgency, frequency, overactivity, and pain may be viewed as a consequence of urothelial defects (either urothelial barrier breakdown or inappropriate signaling from urothelial cells to underlying sensory afferents and potentially interstitial cells). This review describes the physiologic and anatomic mechanisms by which urine is moved from the kidney to the bladder, stored, and then released. Relevant clinical examples of urinary tract dysfunction are also discussed.
authors.affiliation: Laboratory of Voiding Dysfunction, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts whill@bidmc.harvard.edu.
authors.forename: Warren G
authors.initials: WG
authors.lastname: Hill
mesh_terms: D006801:Humans; D056885:Interstitial Cells of Cajal / Q000502:physiology; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology; D009434:Neural Pathways; D014513:Ureter / Q000033:anatomy & histology / Q000502:physiology*; D014521:Urethra / Q000033:anatomy & histology / Q000502:physiology*; D001743:Urinary Bladder / Q000033:anatomy & histology* / Q000294:innervation / Q000502:physiology*; D014554:Urination / Q000502:physiology*; D019459:Urothelium / Q000502:physiology*
keywords: calcium; cell and transport physiology; cell signaling; epithelial; urinary tract
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