title: Hearing outcome of early postnatal exposure to hypoxia in Sprague-Dawley rats.
abstract: OBJECTIVE
  To determine the effect of experimentally induced hypoxia, in the first 10 days of life, on physiological hearing in a Sprague-Dawley rat model.
  
  
  METHODS
  A prospective, controlled animal study was carried out using 22 male rat pups. The rats in the hypoxic group (n= 12) were reared in hypoxia for the first 10 days of life, and subsequently reared in normoxia, while those in the control group (n= 10) were reared in normoxia for the duration of the experiment. Hearing was assessed using auditory brainstem response testing at approximately 72 days of age.
  
  
  RESULTS
  The hypoxia group had higher auditory brainstem response thresholds for all frequencies tested (more pronounced at 16 kHz), compared with controls. Wave I-V inter-peak latencies were more prolonged in the hypoxic rats, while both groups had similar wave I latencies.
  
  
  CONCLUSIONS
  Chronic postnatal hypoxia induced permanent hearing loss in this Sprague-Dawley rat model. Prolonged wave I-V inter-peak latencies suggested functional abnormality in the central auditory pathway.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Montreal Children's Hospital - McGill University Health Centre, Quebec, Canada.|McGill Auditory Sciences Laboratory, Montreal Children's Hospital - McGill University Health Centre, Quebec, Canada.
authors.forename: S J
authors.initials: SJ
authors.lastname: Daniel
authors.affiliation: Division of Cardiology, Montreal Children's Hospital - McGill University Health Centre, Quebec, Canada.
authors.forename: M
authors.initials: M
authors.lastname: McIntosh
authors.affiliation: McGill Auditory Sciences Laboratory, Montreal Children's Hospital - McGill University Health Centre, Quebec, Canada.
authors.forename: O V
authors.initials: OV
authors.lastname: Akinpelu
authors.affiliation: Division of Cardiology, Montreal Children's Hospital - McGill University Health Centre, Quebec, Canada.|Department of Physiology, McGill University, Montreal, Quebec, Canada.
authors.forename: C V
authors.initials: CV
authors.lastname: Rohlicek
mesh_terms: D000818:Animals; D017207:Rats, Sprague-Dawley; D051381:Rats; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D000860:Hypoxia / Q000503:physiopathology; D000831:Animals, Newborn; D008297:Male; D004195:Disease Models, Animal; D006309:Hearing / Q000502:physiology; D001309:Auditory Threshold / Q000502:physiology; D034381:Hearing Loss / Q000209:etiology / Q000503:physiopathology; D011446:Prospective Studies
keywords: Animals, Neonatal; Auditory Brainstem Responses; Central Auditory Pathway Disorders; Cochlea; Evoked Potentials; Hypoxia; Rats, Sprague-Dawley