title: Hepatoprotective effect of fucoidan isolated from the seaweed Turbinaria decurrens in ethanol intoxicated rats.
abstract: Fucoidan is the sulfated polysaccharide which is present in the cell wall of the brown seaweeds with high nutritive value. It is widely known for its pharmacological activity and hence it is added as a main ingredient in the food supplements. A water soluble crude polysaccharide was extracted from Turbinaria decurrens. Ethanol has been used as a hepatotoxin in vivo and its administration increased oxidative stress, decreased antioxidant defence and liver injury. Fucoidan treatment increased the body weight, food intake and serum protein levels, it decreases the level of hepatic markers. Fucoidan improved the antioxidant status of alcoholic rats, which is evaluated by the decreased levels of lipid peroxidation markers and increased level of enzymatic antioxidants were observed in liver. Histopathological observations and protein expression were also in correlation with the biochemical parameters. The hepatoprotective effect of fucoidan is probably due to its antioxidant effect.
authors.affiliation: CAS in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608 502, Tamil Nadu, India. Electronic address: smeenakshi85@gmail.com.
authors.forename: Selvaraju
authors.initials: S
authors.lastname: Meenakshi
authors.affiliation: CAS in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608 502, Tamil Nadu, India.
authors.forename: Shanmugam
authors.initials: S
authors.lastname: Umayaparvathi
authors.affiliation: CAS in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608 502, Tamil Nadu, India.
authors.forename: Ravichandran
authors.initials: R
authors.lastname: Saravanan
authors.affiliation: CAS in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608 502, Tamil Nadu, India.
authors.forename: Tamilarasan
authors.initials: T
authors.lastname: Manivasagam
authors.affiliation: CAS in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608 502, Tamil Nadu, India.
authors.forename: Thangavel
authors.initials: T
authors.lastname: Balasubramanian
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D000431:Ethanol / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D000459:Phaeophyceae / Q000737:chemistry; D011134:Polysaccharides / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification*; D051381:Rats
chemical_list: D000975:Antioxidants; D011134:Polysaccharides; D000431:Ethanol; C007789:fucoidan
keywords: Fucoidan; Hepatoprotective; Liver damage; T. decurrens