title: Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer.
abstract: BACKGROUND
  In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.
  
  
  METHODS
  A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70 Gy (62.4-75 Gy).
  
  
  RESULTS
  At a median follow-up of 14 months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.
  
  
  CONCLUSIONS
  IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.
authors.affiliation: Department of Radiation Oncology, Howard University Hospital, 2401 Georgia Avenue, N,W,, Room 2055, Washington, DC 20060, USA. NamPhong.Nguyen@yahoo.com.
authors.forename: Nam P
authors.initials: NP
authors.lastname: Nguyen
authors.forename: Siyoung
authors.initials: S
authors.lastname: Jang
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Vock
authors.forename: Vincent
authors.initials: V
authors.lastname: Vinh-Hung
authors.forename: Alexander
authors.initials: A
authors.lastname: Chi
authors.forename: Paul
authors.initials: P
authors.lastname: Vos
authors.forename: Judith
authors.initials: J
authors.lastname: Pugh
authors.forename: Richard A
authors.initials: RA
authors.lastname: Vo
authors.forename: Misty
authors.initials: M
authors.lastname: Ceizyk
authors.forename: Anand
authors.initials: A
authors.lastname: Desai
authors.forename: Lexie
authors.initials: L
authors.lastname: Smith-Raymond
mesh_terms: D000368:Aged; D004938:Esophageal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D061089:Radiotherapy, Image-Guided / Q000009:adverse effects / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated
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