title: Synthesis and in vitro assessment of a bifunctional closomer probe for fluorine ((19)F) magnetic resonance and optical bimodal cellular imaging.
abstract: The design, synthesis and in vitro assessment of a bifunctional imaging probe for dual fluorine ((19)F) magnetic resonance spectroscopy ((19)F-MRS) and fluorescence detection is reported. Eleven copies of 3,5-bis(trifluoromethyl)phenyl and a single copy of a sulforhodamine-B were covalently attached to a closo-B12(2-)-core via suitable linkers. The (19)F-MRS and fluorescence imaging shows that, this novel bimodal imaging probe was readily taken up by the cells in vitro after co-incubation.
authors.affiliation: International Institute of Nano and Molecular Medicine, School of Medicine, University of Missouri, Columbia, Missouri 65211-3450, USA. hawthornem@missouri.edu.
authors.forename: Lalit N
authors.initials: LN
authors.lastname: Goswami
authors.forename: Aslam A
authors.initials: AA
authors.lastname: Khan
authors.forename: Satish S
authors.initials: SS
authors.lastname: Jalisatgi
authors.forename: M Frederick
authors.initials: MF
authors.lastname: Hawthorne
mesh_terms: D002460:Cell Line; D060326:Chemistry Techniques, Synthetic; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry*; D005461:Fluorine; D006801:Humans; D008279:Magnetic Resonance Imaging; D061848:Optical Imaging
chemical_list: D005456:Fluorescent Dyes; D005461:Fluorine