title: Evaluating the role of mitochondrial DNA variation to the genetic predisposition to radiation-induced toxicity.
abstract: OBJECTIVE
  Mitochondrial DNA common variants have been reported to be associated with the development of radiation-induced toxicity. Using a large cohort of patients, we aimed to validate these findings by investigating the potential role of common European mitochondrial DNA SNPs (mtSNPs) to the development of radio-toxicity.
  
  
  METHODS
  Overall acute and late toxicity data were assessed in a cohort of 606 prostate cancer patients by means of Standardized Total Average Toxicity (STAT) score. We carried out association tests between radiation toxicity and a selection of 15 mtSNPs (and the haplogroups defined by them).
  
  
  RESULTS
  Statistically significant association between mtSNPs and haplogroups with toxicity could not be validated in our Spanish cohort.
  
  
  CONCLUSIONS
  The present study suggests that the mtDNA common variants analyzed are not associated with clinically relevant increases in risk of overall radiation-induced toxicity in prostate cancer patients.
authors.affiliation: Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica, CIBERER, IDIS, Santiago de Compostela, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Fachal
authors.affiliation: Unidade de Xenética, Instituto de Ciencias Forenses and Departamento de Anatomía Patolóxica e Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, Galicia, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Mosquera-Miguel
authors.affiliation: Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gómez-Caamaño
authors.affiliation: Department of Medical Physics, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Sánchez-García
authors.affiliation: Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Calvo
authors.affiliation: Department of Medical Physics, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: Lobato-Busto
authors.affiliation: Unidade de Xenética, Instituto de Ciencias Forenses and Departamento de Anatomía Patolóxica e Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, Galicia, Spain. Electronic address: antonio.salas@usc.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Salas
authors.affiliation: Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica, CIBERER, IDIS, Santiago de Compostela, Spain. Electronic address: ana.vega@usc.es.
authors.forename: Ana
authors.initials: A
authors.lastname: Vega
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000235:genetics / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000235:genetics*; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D013030:Spain; D044465:White People
chemical_list: D004272:DNA, Mitochondrial
keywords: 3D-CRT; Prostate cancer; SNP; mtDNA