title: [Outcomes of treatment of 32 cases of advanced or relapsed post-surgery pulmonary sarcomatoid carcinoma].
abstract: OBJECTIVE
  To determine the efficacy of the third generation chemotherapy agents on relapsed post-surgery and advanced pulmonary sarcomatoid carcinoma (PSC).
  
  
  METHODS
  We reviewed the medical records of 32 PSC patients. Their treatment modalities and survival rate, as well as risk factors associated with the survival rate including gender, age, location and size of tumor, relapse, initial diagnosis of stage, pathologic subtypes and smoking history were analysed.
  
  
  RESULTS
  All of the 32 PSC patients received chemotherapy with gemcitabine combined with cisplatin (GP) or paclitaxel combined with cisplatin (TP). They had a median of 14 months overall survive (OS) and 5 months progress-free survive (PFS). The remission rate was 21.9%. An initial stage IV diagnosis and a larger than 6 cm tumor in diameter were independent factors associated with poor prognosis.
  
  
  CONCLUSIONS
  The efficacy of TP and GP chemotherapy on patients with relapsed post-surgery and advanced PSC is comparable with that reported by other researchers. An initial stage IV diagnosis and a larger than 6 cm tumor in diameter are predictors of poor prognosis.
authors.forename: Wei-Jie
authors.initials: WJ
authors.lastname: Xiong
authors.forename: Xin-Xing
authors.initials: XX
authors.lastname: Zhang
authors.forename: Mei-Juan
authors.initials: MJ
authors.lastname: Huang
authors.forename: Liu
authors.initials: L
authors.lastname: Chen
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Song
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Xue
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Wang
authors.forename: You
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000970:Antineoplastic Agents; D000971:Antineoplastic Combined Chemotherapy Protocols; D002277:Carcinoma / Q000628:therapy*; D002945:Cisplatin; D003841:Deoxycytidine / Q000031:analogs & derivatives; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D009364:Neoplasm Recurrence, Local; D017239:Paclitaxel; D011184:Postoperative Period; D015996:Survival Rate; D000093542:Gemcitabine
chemical_list: D000970:Antineoplastic Agents; D003841:Deoxycytidine; D017239:Paclitaxel; D002945:Cisplatin; D000093542:Gemcitabine