title: TRPM6.
abstract: TRPM6 is a bifunctional protein comprising a TRP cation channel segment covalently linked to an α-type serine/threonine protein kinase. TRPM6 is expressed in the intestinal and renal epithelial cells. Loss-of-function mutations in the human TRPM6 gene give rise to hypomagnesemia with secondary hypocalcemia (HSH), suggesting that the TRPM6 channel kinase plays a central role in systemic Mg(2+) homeostasis. In contrast, Trpm6 null mice show a delay in prenatal development, neural tube defects, and prenatal death. Possible functions of TRPM6 in prenatal and adult organisms will be discussed in this chapter.
authors.affiliation: Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians University Munich, Goethestrasse 33, Munich, 80336, Germany, vladimir.chubanov@lrz.uni-muenchen.de.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Chubanov
authors.forename: Thomas
authors.initials: T
authors.lastname: Gudermann
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D015640:Ion Channel Gating; D008564:Membrane Potentials; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D011487:Protein Conformation; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D050053:TRPM Cation Channels / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
chemical_list: D050053:TRPM Cation Channels; C459082:TRPM6 protein, human; C530168:Trpm6 protein, mouse