title: Sensing core histone phosphorylation - a matter of perfect timing.
abstract: Systematic analysis of histone modifications has revealed a plethora of posttranslational modifications that mediate changes in chromatin structure and gene expression. Histone phosphorylation is a transient histone modification that becomes induced by extracellular signals, DNA damage or entry into mitosis. Importantly, phosphorylation of histone proteins does lead not only to the binding of specific reader proteins but also to changes in the affinity for readers or writers of other histone modifications. This induces a cross-talk between different chromatin modifications that allows the spatio-temporal control of chromatin-associated events. In this review we will summarize the progress in our current knowledge of factors sensing reversible histone phosphorylation in different biological scenarios. This article is part of a Special Issue entitled: Molecular mechanisms of histone modification function.
authors.affiliation: Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna Biocenter, Vienna, Austria.
authors.forename: Anna
authors.initials: A
authors.lastname: Sawicka
authors.affiliation: Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna Biocenter, Vienna, Austria. Electronic address: christian.seiser@univie.ac.at.
authors.forename: Christian
authors.initials: C
authors.lastname: Seiser
mesh_terms: D048948:14-3-3 Proteins / Q000235:genetics / Q000378:metabolism*; D000107:Acetylation; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D044127:Epigenesis, Genetic; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D008938:Mitosis; D010766:Phosphorylation; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D048948:14-3-3 Proteins; D002843:Chromatin; D006657:Histones
keywords: DNA damage; Histone code; Histone phosphorylation; Mitosis; Transcription
references.citation: Mol Cell. 2001 Dec;8(6):1231-41
references.pmid: 11779499
references.citation: Nat Struct Mol Biol. 2012 Sep;19(9):930-7
references.pmid: 22885324
references.citation: PLoS One. 2013;8(2):e55703
references.pmid: 23418452
references.citation: Cell. 2007 Feb 23;128(4):693-705
references.pmid: 17320507
references.citation: EMBO J. 2005 Mar 9;24(5):997-1008
references.pmid: 15719021
references.citation: Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2801-6
references.pmid: 21282660
references.citation: Cell. 2003 Aug 8;114(3):371-383
references.pmid: 12914701
references.citation: Mol Cell. 2010 Dec 10;40(5):689-701
references.pmid: 21145479
references.citation: Nat Cell Biol. 2002 Dec;4(12):993-7
references.pmid: 12447390
references.citation: Genes Dev. 2004 Mar 15;18(6):602-16
references.pmid: 15075289
references.citation: Nat Cell Biol. 2010 Jul;12(7):719-27
references.pmid: 20562864
references.citation: EMBO J. 2008 Jan 9;27(1):88-99
references.pmid: 18059471
references.citation: EMBO J. 2005 Jan 26;24(2):347-57
references.pmid: 15616580
references.citation: Nat Genet. 2008 Jul;40(7):897-903
references.pmid: 18552846
references.citation: EMBO Rep. 2003 Jul;4(7):678-84
references.pmid: 12792653
references.citation: Nature. 2001 Mar 1;410(6824):116-20
references.pmid: 11242053
references.citation: Biochem J. 1966 Mar;98(3):888-97
references.pmid: 5911533
references.citation: Development. 2007 Jan;134(2):223-32
references.pmid: 17185323
references.citation: Nat Genet. 1998 Jun;19(2):175-8
references.pmid: 9620776
references.citation: Nucleic Acids Res. 2010 Aug;38(15):4958-69
references.pmid: 20385584
references.citation: FEBS Lett. 2002 Feb 20;513(1):53-7
references.pmid: 11911880
references.citation: Nat Genet. 2001 Mar;27(3):247-54
references.pmid: 11242102
references.citation: Mol Cell. 2013 Nov 21;52(4):583-90
references.pmid: 24211264
references.citation: Leuk Lymphoma. 2001 Jan;40(3-4):259-66
references.pmid: 11426547
references.citation: Mol Cell. 2010 Sep 24;39(6):886-900
references.pmid: 20864036
references.citation: Nature. 2009 Oct 8;461(7265):819-22
references.pmid: 19783980
references.citation: Nature. 2003 Oct 2;425(6957):475-9
references.pmid: 14523437
references.citation: Biochimie. 2012 Nov;94(11):2193-201
references.pmid: 22564826
references.citation: Epigenetics. 2012 Oct;7(10):1098-108
references.pmid: 22948226
references.citation: Biochem Cell Biol. 2001;79(3):243-52
references.pmid: 11467738
references.citation: Nature. 2005 Dec 22;438(7071):1116-22
references.pmid: 16222246
references.citation: Cold Spring Harb Symp Quant Biol. 2004;69:219-26
references.pmid: 16117652
references.citation: Science. 2010 Oct 8;330(6001):235-9
references.pmid: 20705815
references.citation: Nat Protoc. 2012 Apr 12;7(5):882-90
references.pmid: 22498708
references.citation: Nucleic Acids Res. 2010 Jun;38(10):3196-208
references.pmid: 20129940
references.citation: Curr Opin Cell Biol. 2001 Apr;13(2):225-31
references.pmid: 11248557
references.citation: EMBO Rep. 2004 May;5(5):490-6
references.pmid: 15105826
references.citation: Mol Cell. 2008 Apr 25;30(2):123-35
references.pmid: 18439892
references.citation: Blood. 2008 Nov 1;112(9):3889-99
references.pmid: 18689541
references.citation: Cell. 2010 Sep 17;142(6):967-80
references.pmid: 20850016
references.citation: Nat Cell Biol. 2003 Jul;5(7):675-9
references.pmid: 12792649
references.citation: Cell Rep. 2012 Sep 27;2(3):470-7
references.pmid: 22999934
references.citation: Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8173-8
references.pmid: 12034884
references.citation: J Cell Sci. 2003 Aug 15;116(Pt 16):3327-38
references.pmid: 12840071
references.citation: Trends Biochem Sci. 2010 Nov;35(11):618-26
references.pmid: 20685123
references.citation: Expert Rev Proteomics. 2011 Oct;8(5):631-43
references.pmid: 21999833
references.citation: Science. 2002 May 3;296(5569):922-7
references.pmid: 11934988
references.citation: J Proteome Res. 2004 Nov-Dec;3(6):1219-27
references.pmid: 15595731
references.citation: FEBS Lett. 1996 Aug 12;391(3):252-6
references.pmid: 8764984
references.citation: Mol Cell Biol. 2008 Apr;28(8):2840-9
references.pmid: 18268010
references.citation: Nat Struct Mol Biol. 2012 Aug;19(8):819-23
references.pmid: 22796964
references.citation: Curr Biol. 2004 Oct 5;14(19):1703-11
references.pmid: 15458641
references.citation: Cell. 2005 Dec 29;123(7):1213-26
references.pmid: 16377563
references.citation: J Cell Sci. 2005 May 15;118(Pt 10):2247-59
references.pmid: 15870105
references.citation: Science. 2010 Oct 8;330(6001):239-43
references.pmid: 20929775
references.citation: Nucleic Acids Res. 2003 Feb 1;31(3):878-85
references.pmid: 12560483
references.citation: PLoS Genet. 2010 Jun 03;6(6):e1000975
references.pmid: 20532201
references.citation: Nature. 2001 Mar 1;410(6824):120-4
references.pmid: 11242054
references.citation: Mol Cell. 2012 Apr 27;46(2):115-24
references.pmid: 22541554
references.citation: Exp Cell Res. 1996 Dec 15;229(2):282-8
references.pmid: 8986611
references.citation: Bioinform Biol Insights. 2013 Aug 26;7:271-88
references.pmid: 24027420
references.citation: Mol Biol Cell. 2006 Jun;17(6):2547-58
references.pmid: 16571674
references.citation: Nat Cell Biol. 2008 Jan;10(1):53-60
references.pmid: 18066052
references.citation: Nat Rev Mol Cell Biol. 2013 Sep;14(9):563-80
references.pmid: 23969844
references.citation: Science. 2014 Jan 3;343(6166):77-80
references.pmid: 24385627
references.citation: J Biol Chem. 2003 May 2;278(18):15744-8
references.pmid: 12595522
references.citation: Cell Cycle. 2011 Aug 1;10(15):2461-70
references.pmid: 21734457
references.citation: J Biol Chem. 2010 Dec 24;285(52):41062-73
references.pmid: 20952396
references.citation: Science. 2010 Oct 8;330(6001):231-5
references.pmid: 20705812
references.citation: Oncogene. 2005 May 12;24(21):3492-502
references.pmid: 15735677
references.citation: Trends Biochem Sci. 2004 Nov;29(11):579-85
references.pmid: 15501676
references.citation: EMBO Rep. 2003 Sep;4(9):844-9
references.pmid: 12949583
references.citation: Cell Cycle. 2008 May 15;7(10):1336-42
references.pmid: 18418070
references.citation: J Cell Biol. 1998 Dec 28;143(7):1763-74
references.pmid: 9864353
references.citation: Nature. 2005 Dec 22;438(7071):1176-80
references.pmid: 16222244
references.citation: Nature. 2000 Aug 10;406(6796):593-9
references.pmid: 10949293
references.citation: Nat Struct Mol Biol. 2013 Oct;20(10):1147-55
references.pmid: 24096405
references.citation: Science. 2002 Mar 15;295(5562):2080-3
references.pmid: 11859155
references.citation: Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14381-6
references.pmid: 22908299
references.citation: Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12950-5
references.pmid: 22837395
references.citation: Nature. 2007 Jul 5;448(7149):87-91
references.pmid: 17589501
references.citation: Mol Biol Cell. 2004 Oct;15(10):4356-68
references.pmid: 15269281
references.citation: Mol Cell. 2000 Jun;5(6):905-15
references.pmid: 10911985
references.citation: Nat Struct Mol Biol. 2007 Nov;14(11):1025-1040
references.pmid: 17984965
references.citation: Mol Cell. 2005 Oct 28;20(2):199-211
references.pmid: 16246723
references.citation: Science. 2001 Aug 10;293(5532):1142-6
references.pmid: 11498592
references.citation: Nature. 2009 Jan 1;457(7225):57-62
references.pmid: 19092802
references.citation: Nat Struct Mol Biol. 2014 Jan;21(1):103-9
references.pmid: 24336221
references.citation: J Biol Chem. 1975 Jul 10;250(13):4856-63
references.pmid: 168194
references.citation: Cell. 2007 Oct 5;131(1):58-69
references.pmid: 17884155
references.citation: Mol Cell Biol. 2007 Oct;27(20):7028-40
references.pmid: 17709392
references.citation: Nature. 2010 Apr 1;464(7289):792-6
references.pmid: 20228790
references.citation: Biochem J. 1966 Aug;100(2):20C-1C
references.pmid: 16742404
references.citation: PLoS Genet. 2010 Apr 29;6(4):e1000927
references.pmid: 20442873
references.citation: Cell. 2009 Sep 18;138(6):1122-36
references.pmid: 19766566
references.citation: Genes Dev. 2007 Feb 15;21(4):420-35
references.pmid: 17322402
references.citation: EMBO J. 2010 Dec 1;29(23):3967-78
references.pmid: 20953165
references.citation: Nature. 2007 May 24;447(7143):407-12
references.pmid: 17522673
references.citation: Nat Cell Biol. 2009 Jul;11(7):865-72
references.pmid: 19525936
references.citation: Nature. 2009 Apr 2;458(7238):591-6
references.pmid: 19234442
references.citation: J Cell Biol. 1999 Sep 6;146(5):905-16
references.pmid: 10477747
references.citation: J Biol Chem. 2001 Nov 9;276(45):42462-7
references.pmid: 11571274
references.citation: Structure. 2008 Aug 6;16(8):1245-56
references.pmid: 18682226
references.citation: J Biol Chem. 1998 Mar 6;273(10):5858-68
references.pmid: 9488723
references.citation: Mol Cell. 2000 Jun;5(6):917-26
references.pmid: 10911986
references.citation: Proc Natl Acad Sci U S A. 1994 May 24;91(11):4781-5
references.pmid: 8197135
references.citation: Plant Cell. 1999 Aug;11(8):1591-602
references.pmid: 10449590
references.citation: Nat Rev Cancer. 2012 May 24;12(6):387-400
references.pmid: 22622641