title: Intranasal curcumin attenuates airway remodeling in murine model of chronic asthma.
abstract: Curcumin, phytochemical present in turmeric, rhizome of Curcuma longa, a known anti-inflammatory molecule with variety of pharmacological activities is found effective in murine model of chronic asthma characterized by structural alterations and airway remodeling. Here, we have investigated the effects of intranasal curcumin in chronic asthma where animals were exposed to allergen for longer time. In the present study Balb/c mice were sensitized by an intraperitoneal injection of ovalbumin (OVA) and subsequently challenged with 2% OVA in aerosol twice a week for five consecutive weeks. Intranasal curcumin (5mg/kg) was administered from days 21 to 55, an hour before every nebulization and inflammatory cells recruitment, levels of IgE, EPO, IL-4 and IL-5 were found suppressed in bronchoalveolar lavage fluid (BALF). Intranasal curcumin administration prevented accumulation of inflammatory cells to the airways, structural alterations and remodeling associated with chronic asthma like peribronchial and airway smooth muscle thickening, sloughing off of the epithelial lining and mucus secretion in ovalbumin induced murine model of chronic asthma.
authors.affiliation: Department of Zoology, MMV, Banaras Hindu University, Varanasi 221005, India.
authors.forename: Preeti S
authors.initials: PS
authors.lastname: Chauhan
authors.affiliation: Department of Zoology, MMV, Banaras Hindu University, Varanasi 221005, India.
authors.lastname: Subhashini
authors.affiliation: Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
authors.forename: D
authors.initials: D
authors.lastname: Dash
authors.affiliation: Department of Zoology, MMV, Banaras Hindu University, Varanasi 221005, India. Electronic address: rashmirs98@rediffmail.com.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Singh
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D002908:Chronic Disease; D030024:Curcuma / Q000276:immunology*; D003474:Curcumin / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D015847:Interleukin-4 / Q000378:metabolism; D015848:Interleukin-5 / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D032389:Myocytes, Smooth Muscle / Q000187:drug effects* / Q000473:pathology; D010047:Ovalbumin / Q000276:immunology
chemical_list: D015848:Interleukin-5; D015847:Interleukin-4; D007073:Immunoglobulin E; D010047:Ovalbumin; D003474:Curcumin
keywords: Airway remodeling; Chronic asthma; Goblet cell; Inflammation