title: Interferon beta-associated recurrence of painful trigeminal neuropathy attributed to a multiple sclerosis plaque.
abstract: We report the case of a 49-year-old woman with painful trigeminal neuropathy in the right maxillary division attributed to a multiple sclerosis plaque as the presenting symptom of multiple sclerosis. The patient was initially treated with intravenous corticosteroids and was pain free on pregabalin for six months. She was then started on an immunomodulatory treatment and coinciding with the up-titration of interferon beta-1a, she experienced recurrence of painful trigeminal neuropathy as well as weekly migraine attacks. Worsening of primary headache disorders by interferon treatment has been previously reported. Our case suggests that treatment with interferon beta may also exacerbate symptomatic trigeminal neuralgia in multiple sclerosis.
authors.affiliation: Department of Neurology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland. Antje.Bischof@usb.ch.
authors.forename: Antje
authors.initials: A
authors.lastname: Bischof
authors.forename: Till
authors.initials: T
authors.lastname: Sprenger
mesh_terms: D005260:Female; D006801:Humans; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000009:adverse effects*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D012008:Recurrence; D014277:Trigeminal Neuralgia / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*
chemical_list: D016899:Interferon-beta; D000068556:Interferon beta-1a
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