title: Cytogenetic monitoring of nuclear workers occupationally exposed to ionising radiation.
abstract: Chromosome aberration (CA) analysis using Giemsa techniques was performed in blood lymphocytes of 84 nuclear workers with cumulative doses of 1-632 mSv during employment periods of 1-25 y. The control group comprised 82 healthy male donors. An estimated CA frequency in the total radiation-exposed group was significantly higher when compared with the controls (2.27 vs. 1.76 CA/100 cells, p < 0.05). CA analyses revealed no significant differences between workers with external gamma radiation exposure and the controls (1.60 vs. 1.76 CA/100 cells, p > 0.05). However, significant increase in the total CA frequency was determined in workers with additional internal exposure (2.54 CA/100 cells, p < 0.05) and those with registered neutron doses (2.95 CA/100 cells, p < 0.01). No correlation was found between CA frequency and occupational exposure dose. Borderline significant correlation was found between duration of employment and total CA (r = 0.218, p = 0.046, Fig. 2) and chromosome-type aberration (r = 0.265, p = 0.015) frequency.
authors.affiliation: Department of Radiology, Nuclear Medicine and Physics of Medicine, Faculty of Medicine, Vilnius University, Santariškių 2, LT-08661 Vilnius, Lithuania Department of Botany and Genetics, Faculty of Natural Sciences, Vilnius University, M.K. Čiurlionio 21/27, LT-03101 Vilnius, Lithuania birute.griciene@gmail.com.
authors.forename: B
authors.initials: B
authors.lastname: Gricienė
authors.affiliation: Department of Botany and Genetics, Faculty of Natural Sciences, Vilnius University, M.K. Čiurlionio 21/27, LT-03101 Vilnius, Lithuania.
authors.forename: G
authors.initials: G
authors.lastname: Slapšytė
authors.affiliation: Department of Botany and Genetics, Faculty of Natural Sciences, Vilnius University, M.K. Čiurlionio 21/27, LT-03101 Vilnius, Lithuania.
authors.forename: J
authors.initials: J
authors.lastname: Mierauskienė
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002869:Chromosome Aberrations / Q000528:radiation effects*; D020732:Cytogenetic Analysis / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D055848:Nuclear Power Plants; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis*; D011832:Radiation Injuries / Q000175:diagnosis* / Q000209:etiology; D011839:Radiation, Ionizing; D018570:Risk Assessment