title: Frequency of CYP450 enzyme gene polymorphisms in the Greek population: review of the literature, original findings and clinical significance.
abstract: The cytochrome P450 (CYP450) enzyme family is involved in the oxidative metabolism of many therapeutic drugs and various endogenous substrates. These enzymes are highly polymorphic. Prevalence of CYP450 enzyme gene polymorphisms vary among different populations and substantial inter- and intra-ethnic variability in frequency of CYP450 enzyme gene polymorphisms has been reported. This paper provides an overview and investigation of CYP450 genotypic and phenotypic reports published in the Greek population.
authors.forename: Georgia
authors.initials: G
authors.lastname: Ragia
authors.forename: Efstathia
authors.initials: E
authors.lastname: Giannakopoulou
authors.forename: Makrina
authors.initials: M
authors.lastname: Karaglani
authors.forename: Ioanna-Maria
authors.initials: IM
authors.lastname: Karantza
authors.forename: Anna
authors.initials: A
authors.lastname: Tavridou
authors.forename: Vangelis G
authors.initials: VG
authors.lastname: Manolopoulos
mesh_terms: D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005006:Ethnicity / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods* / Q000639:trends; D011110:Polymorphism, Genetic / Q000235:genetics*; D011159:Population Surveillance / Q000379:methods
chemical_list: D003577:Cytochrome P-450 Enzyme System