title: Multipotent mesenchymal stromal cells in otorhinolaryngology.
abstract: Multipotent mesenchymal stromal cells (MSCs) are primitive cells capable of restoring damaged mesenchyme and with the ability to differentiate into mature cells of bone, cartilage, muscle, fat, nerve or fibrous tissues. MSCs are therefore good candidates for applications in regenerative medicine and cell based therapy. They regenerate through self-renewal, differentiational capacity, immune modulation and secretion of bioactive molecules. Authors present a review of MSCs applications in otorhinolaryngology. The major interest is focused on phonosurgery, sensorineural deafness and reconstruction of large tissue defects with bone, cartilage or soft tissue replacement. Current evidence of MSCs treatment efficacy in otorhinolaryngology is based on animal models. The true impact on clinical treatment will not be known until clinical studies prove functional outcomes in human medicine.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Hradec Kralove, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Czech Republic.
authors.forename: Lukas
authors.initials: L
authors.lastname: Skoloudik
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Hradec Kralove, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Czech Republic.
authors.forename: Viktor
authors.initials: V
authors.lastname: Chrobok
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Hradec Kralove, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Czech Republic. Electronic address: david.k100@seznam.cz.
authors.forename: David
authors.initials: D
authors.lastname: Kalfert
authors.affiliation: Laboratory of Tissue Culture and Stem Cells, Institute of Experimental Medicine, Academy of Science of the Czech Republic, Czech Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Koci
authors.affiliation: Department of Oncology and Radiotherapy, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Czech Republic.
authors.forename: Stanislav
authors.initials: S
authors.lastname: Filip
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000502:physiology; D002356:Cartilage / Q000166:cytology / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D008954:Models, Biological; D009417:Nerve Tissue / Q000166:cytology / Q000502:physiology; D010036:Otolaryngology / Q000379:methods*; D044968:Regenerative Medicine / Q000379:methods*