title: Correlation between serum adiponectin and clinical characteristics, biochemical parameters in Indian women with polycystic ovary syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is a common disorder. PCOS women are at a high risk for insulin resistance and metabolic syndrome (MS). Adiponectin is positively related to insulin sensitivity. It has a preventive role in atherogenesis and MS. The present work was conducted to study the correlation between serum adiponectin levels and clinical characteristics and biochemical parameters in PCOS patients.
  
  
  METHODS
  A prospective study in 49 newly diagnosed (as per Rotterdam criteria) Indian PCOS women was conducted. PCOS women were clinically examined and investigated for biochemical parameters.
  
  
  RESULTS
  The mean serum adiponectin was 12 ± 9.4 μg/mL (range 0.47-45). Hypoadiponectinemia (serum adiponectin <4 μg/mL) was present in 22% patients. Age and adiponectin correlated significantly and inversely (r = -0.42, P = 0.027). Overweight/obese patients had lower mean adiponectin levels than normal weight (11.62 ± 9.5 vs 13.58 ± 9.5, P = 0.56). It was significantly lower in patients with acanthosis nigricans (AN) as compared with those without AN (8.4 ± 5.9 vs 15 ± 11, P = 0.038). Hirsute patients showed lower mean adiponectin levels than nonhirsute (10 ± 7.3 vs 13 ± 10, P = 0.57). A positive, insignificant correlation was observed between serum adiponectin and cholesterol, low-density lipoprotein, follicle stimulating hormone (FSH), thyroid stimulating hormone, levels. A negative insignificant correlation existed between serum adiponectin and luteinizing hormone (LH), LH: FSH ratio, prolactin, dehydroepiandrosterone, testosterone, triglyceride, high-density lipoprotein, fasting blood glucose, fasting insulin, and Homeostasis Model Assessment.
  
  
  CONCLUSIONS
  Hypoadiponectinemia is present in one-fifth of women with PCOS. Adiponectin levels decrease as age advances. Low levels of adiponectin possibly contributes to the development of dermal manifestation (AN) of insulin resistance.
authors.affiliation: Department of Pharmacology, Govt. Medical College, Miraj, Maharashtra, India.
authors.forename: Sunita J
authors.initials: SJ
authors.lastname: Ramanand
authors.affiliation: Department of Pharmacology, R.C.S.M. Government Medical College, Kolhapur, Maharashtra, India.
authors.forename: Jaiprakash B
authors.initials: JB
authors.lastname: Ramanand
authors.affiliation: Department of Pharmacology, Govt. Medical College, Miraj, Maharashtra, India.
authors.forename: Balasaheb B
authors.initials: BB
authors.lastname: Ghongane
authors.affiliation: Patwardhan Endocrinology Hospital and Research Centre, Miraj, Maharashtra, India.
authors.forename: Milind H
authors.initials: MH
authors.lastname: Patwardhan
authors.affiliation: Patwardhan Endocrinology Hospital and Research Centre, Miraj, Maharashtra, India.
authors.forename: Varsha M
authors.initials: VM
authors.lastname: Patwardhan
authors.affiliation: Department of Pharmacology, Govt. Medical College, Miraj, Maharashtra, India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Ghanghas
authors.affiliation: Department of Pharmacology, Govt. Medical College, Miraj, Maharashtra, India.
authors.forename: Nimish R
authors.initials: NR
authors.lastname: Halasawadekar
authors.affiliation: Department of Pharmacology, Govt. Medical College, Miraj, Maharashtra, India.
authors.forename: Praveenkumar
authors.initials: P
authors.lastname: Patil
keywords: Acanthosis nigricans; PCOS; adiponectin; insulin resistance
references.citation: Mol Endocrinol. 2008 Mar;22(3):760-71
references.pmid: 18006641
references.citation: Hum Reprod. 2003 Sep;18(9):1790-6
references.pmid: 12923129
references.citation: J Clin Endocrinol Metab. 2003 Jun;88(6):2619-23
references.pmid: 12788865
references.citation: Korean J Fam Med. 2011 May;32(4):243-8
references.pmid: 22745860
references.citation: J Clin Endocrinol Metab. 2000 Dec;85(12):4426-33
references.pmid: 11134088
references.citation: J Biol Chem. 1995 Nov 10;270(45):26746-9
references.pmid: 7592907
references.citation: J Clin Endocrinol Metab. 2001 May;86(5):1930-5
references.pmid: 11344187
references.citation: Endocr J. 2006 Aug;53(4):555-62
references.pmid: 16849835
references.citation: Br Med J (Clin Res Ed). 1986 Aug 9;293(6543):355-9
references.pmid: 3089520
references.citation: Diabetes Care. 2003 Aug;26(8):2442-50
references.pmid: 12882876
references.citation: Biochem Biophys Res Commun. 1999 Apr 2;257(1):79-83
references.pmid: 10092513
references.citation: J Diabetes Sci Technol. 2010 May 01;4(3):645-51
references.pmid: 20513331
references.citation: Fertil Steril. 2004 Jan;81(1):19-25
references.pmid: 14711538
references.citation: Fertil Steril. 1995 Jan;63(1):58-62
references.pmid: 7805925
references.citation: Clin Endocrinol (Oxf). 2005 Apr;62(4):487-91
references.pmid: 15807881
references.citation: Gynecol Endocrinol. 1987 Sep;1(3):235-45
references.pmid: 3140583
references.citation: Lancet. 2002 Jul 6;360(9326):57-8
references.pmid: 12114044
references.citation: Biol Res Nurs. 2010 Jul;12(1):62-72
references.pmid: 20498127
references.citation: J Assoc Physicians India. 2009 Feb;57:163-70
references.pmid: 19582986
references.citation: Hum Reprod. 2006 Sep;21(9):2257-65
references.pmid: 16675483
references.citation: Indian J Clin Biochem. 2011 Apr;26(2):193-6
references.pmid: 22468049
references.citation: Aust N Z J Obstet Gynaecol. 2001 May;41(2):202-6
references.pmid: 11453273
references.citation: Indian J Endocrinol Metab. 2013 Jan;17(1):138-45
references.pmid: 23776867