title: Water-soluble β-cyclodextrin grafted with chitosan and its inclusion complex as a mucoadhesive eugenol carrier.
abstract: Inclusion complex between water-soluble βCD-grafted chitosan derivatives (QCD-g-CS) and eugenol (EG) was investigated as a new type of mucoadhesive drug carrier. The QCD-g-CSs were synthesized with various βCD moieties ranging from 5 to 23%. Spontaneous inclusion complex of these derivatives and EG were found and confirmed by FTIR and simulation study. Self-aggregated formations of QCD-g-CS were found, according to fluorescence and TEM studies, where the formations were preferable for QCD11g-CS and QCD5-g-CS. EG can be included in both βCD hydrophobic cavity and hydrophobic core of QCD-g-CS self-aggregates, resulting in varying entrapment efficiencies. Degree of QCD substitution on QCD-g-CS plays an important role on their physical properties, due to steric hindrance. The QCD11-g-CS showed excellent mucoadhesion, compared to the QCD5-g-CS and QCD23-g-CS. Moreover, the inclusion complex between QCD-g-CS and EG tend to express higher antimicrobial activities against Candida albicans, Streptococcus oralis and Streptococcus mutans, than the native QCD-g-CS.
authors.affiliation: National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathumthani, Thailand.
authors.forename: Warayuth
authors.initials: W
authors.lastname: Sajomsang
authors.affiliation: National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathumthani, Thailand.
authors.forename: Onanong
authors.initials: O
authors.lastname: Nuchuchua
authors.affiliation: National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathumthani, Thailand.
authors.forename: Pattarapond
authors.initials: P
authors.lastname: Gonil
authors.affiliation: National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathumthani, Thailand.
authors.forename: Somsak
authors.initials: S
authors.lastname: Saesoo
authors.affiliation: National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathumthani, Thailand.
authors.forename: Issara
authors.initials: I
authors.lastname: Sramala
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Apinan
authors.initials: A
authors.lastname: Soottitantawat
authors.affiliation: Department of Manufacturing Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
authors.forename: Satit
authors.initials: S
authors.lastname: Puttipipatkhachorn
authors.affiliation: National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathumthani, Thailand.
authors.forename: Uracha Rungsardthong
authors.initials: UR
authors.lastname: Ruktanonchai
mesh_terms: D000268:Adhesiveness; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry*; D005054:Eugenol / Q000008:administration & dosage / Q000737:chemistry*; D009077:Mucins / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012995:Solubility; D013295:Streptococcus mutans / Q000187:drug effects / Q000254:growth & development; D019533:Streptococcus oralis / Q000187:drug effects / Q000254:growth & development; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D004337:Drug Carriers; D004852:Epoxy Compounds; D009077:Mucins; D000644:Quaternary Ammonium Compounds; D047392:beta-Cyclodextrins; D014867:Water; C045006:glycidyl trimethylammonium; D005054:Eugenol; D048271:Chitosan; C031215:betadex