title: Epidemiology, diagnosis, and treatment of Hymenoptera venom allergy in mastocytosis patients.
abstract: Hymenoptera venom allergy is a typical IgE-mediated reaction caused by sensitization to 1 or more allergens of the venom, and accounts for 1.5% to 34% of all cases of anaphylaxis. Patients suffering from mastocytosis are more susceptible to the anaphylactic reactions to an insect sting. This article aims to answer the most important clinical questions raised by the diagnosis and treatment of insect venom allergy in mastocytosis patients. Total avoidance of Hymenoptera is not feasible, and there is no preventive pharmacologic treatment available, although venom immunotherapy reduces the risk of subsequent systemic reactions.
authors.affiliation: Department of Allergology, Medical University of Gdansk, Debinki 7, Gdańsk 80-210, Poland. Electronic address: mnied@gumed.edu.pl.
authors.forename: Marek
authors.initials: M
authors.lastname: Niedoszytko
authors.affiliation: Allergy Unit, Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Aristide Stefani 1, 37126, Verona, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Bonadonna
authors.affiliation: Department of Allergology, University Hospital Groningen, Hanzeplein 1, 9700 RB Groningen, Netherlands.
authors.forename: Joanne N G
authors.initials: JN
authors.lastname: Oude Elberink
authors.affiliation: Division of Allergy-Immunology, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA.
authors.forename: David B K
authors.initials: DB
authors.lastname: Golden
mesh_terms: D000485:Allergens / Q000276:immunology; D000707:Anaphylaxis / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy*; D000818:Animals; D001180:Arthropod Venoms / Q000276:immunology*; D015549:Basophil Degranulation Test; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D006927:Hymenoptera / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood; D007299:Insect Bites and Stings / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy*; D007428:Intradermal Tests; D008297:Male; D008415:Mastocytosis / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy*
chemical_list: D000485:Allergens; D001180:Arthropod Venoms; D007073:Immunoglobulin E
keywords: Hymenoptera venom allergy; Immunoglobulin E serology; Mastocytosis; Venom immunotherapy