title: Consumption of Cisatracurium in different age groups, using a closed loop computer controlled system.
abstract: BACKGROUND
  We devised this study to quantify the effect of age on the consumption of cisatracurium under general anaesthesia, using a computer controlled closed loop infusion system. We further investigated this effect on, sufentanil and propofol consumption.
  
  
  METHODS
  74 patients of physical status I and II, requiring general anaesthesia for elective abdominal surgery, were assigned to three groups. Patients in group 1 were aged from 20 to 45, group 2 were from 46 to 64, and group 3 above 65 years old. General Anesthesia was maintained with propofol and muscle paralysis was maintained using a closed-loop computer controlled infusion of cisatracurium. For analgesia, intermittent bolus of sufentanil 10 μg was given.
  
  
  RESULTS
  Cisatracurium consumption in group 1, 2 and 3 were 1.8 ± 0.3, 1.6 ± 0.4 and 1.3 ± 0.4 μg/kg/min respectively. There was significant difference of cisatracurium consumption between group 1 and 3 (P = 0.002), and the consumption of cisatracurium in group 3 was less as compared with group 2 (P = 0.04). The average recovery index of patients in group 1, 2 and 3 were 8.8 ± 2.6, 11.5 ± 2.9 and 12.7 ± 2.5 minutes respectively. There were difference between group 1 and 2 (P = 0.02). As compared with group 1, the recovery index was still longer in group 3 (P = 0.001). Patients in group 1, 2 and 3 consumed an average sufentanil 0.4 ± 0.1, 0.4 ± 0.1 and 0.3 ± 0.1 μg/kg/hr, respectively. There were statistical significant between group 1 and 3 (P < 0.0001), and the same trend was found between group 2 and 3 (P = 0.03). The Consumption of propofol in group 1, 2 and 3 were 5.1 ± 0.4, 4.3 ± 0.6 and 3.1 ± 0.5 mg/kg/hr. The difference in the propofol consumption was found statistically significant when comparing between any two groups.
  
  
  CONCLUSIONS
  We concluded that the sensitivity of anesthetic agents increased with age. Less medication was required to achieve a desirable effect in older patients specially those above 65 years of age, and the drug effect was prolonged.
  
  
  BACKGROUND
  ClinicalTrials.gov Identifier: NCT01785446.
authors.affiliation: Department of Anaesthesiology, Tianjin Medical University General Hospital, Tianjin Research Institute of Anaesthesiology, No. 154 Anshan Road, Heping District, 300052 Tianjin, China.
authors.forename: Shehzaad
authors.initials: S
authors.lastname: Joomye
authors.affiliation: Department of Anaesthesiology, Tianjin Medical University General Hospital, Tianjin Research Institute of Anaesthesiology, No. 154 Anshan Road, Heping District, 300052 Tianjin, China.
authors.forename: Donglai
authors.initials: D
authors.lastname: Yan
authors.affiliation: Department of Anaesthesiology, Tianjin Medical University General Hospital, Tianjin Research Institute of Anaesthesiology, No. 154 Anshan Road, Heping District, 300052 Tianjin, China.
authors.forename: Haiyun
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Anaesthesiology, Tianjin Second People's Hospital, NO.7 South Road, Nankai District, 300192 Tianjin, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Department of Anaesthesiology, Tianjin Medical University General Hospital, Tianjin Research Institute of Anaesthesiology, No. 154 Anshan Road, Heping District, 300052 Tianjin, China.
authors.forename: Guolin
authors.initials: G
authors.lastname: Wang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000379:methods; D001279:Atracurium / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004360:Drug Therapy, Computer-Assisted; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage*; D015742:Propofol / Q000008:administration & dosage*; D017409:Sufentanil / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D009466:Neuromuscular Blocking Agents; D001279:Atracurium; D017409:Sufentanil; C101584:cisatracurium; D015742:Propofol
keywords: Age; Anesthesia; Cisatracurium; Closed-loop computer controlled infusion system; Propofol; Recovery index; Sufentanil
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