title: Early effects of a hypocaloric, Mediterranean diet on laboratory parameters in obese individuals.
abstract: Calorie restriction is a common strategy for weight loss in obese individuals. However, little is known about the impact of moderate hypocaloric diets on obesity-related laboratory parameters in a short-term period. Aim of this study was to evaluate the variation of laboratory biomarkers in obese individuals following a Mediterranean, hypocaloric (1400-1600 Kcal/die) diet. 23 obese, pharmacologically untreated patients were enrolled and subjected to the determination of anthropometric variables and blood collection at baseline, 1 and 4 months after diet initiation. After 4 months of calorie restriction, we observed a significant decrease in body weight and BMI (both P < 0.0001), insulin (P = 0.037), HOMA-IR (P = 0.026), leptin (P = 0.008), and LDH (P = 0.023) and an increase in EGF (P = 0.013). All these parameters, except LDH, varied significantly already at 1 month after diet initiation. Also, lower levels of insulin (P = 0.025), leptin (P = 0.023), and EGF (P = 0.035) were associated with a greater (>5%) weight loss. Collectively, our data support a precocious improvement of insulin and leptin sensitivity after a modest calorie restriction and weight reduction. Moreover, EGF and LDH may represent novel markers of obesity, which deserve further investigations.
authors.affiliation: Department of Health Sciences, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy.
authors.forename: Marta
authors.identifier: 0000-0003-4192-3891
authors.initials: M
authors.lastname: Greco
authors.affiliation: Department of Health Sciences, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy.
authors.forename: Eusebio
authors.identifier: 0000-0001-5329-3124
authors.initials: E
authors.lastname: Chiefari
authors.affiliation: Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Montalcini
authors.affiliation: Department of Health Sciences, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Accattato
authors.affiliation: Department of Clinical and Experimental Medicine, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy.
authors.forename: Francesco S
authors.initials: FS
authors.lastname: Costanzo
authors.affiliation: Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy.
authors.forename: Arturo
authors.initials: A
authors.lastname: Pujia
authors.affiliation: Department of Health Sciences, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Foti
authors.affiliation: Department of Health Sciences, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy.
authors.forename: Antonio
authors.identifier: 0000-0003-1533-8779
authors.initials: A
authors.lastname: Brunetti
authors.affiliation: Department of Health Sciences, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy.
authors.forename: Elio
authors.initials: E
authors.lastname: Gulletta
mesh_terms: D054392:Adipokines / Q000097:blood; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D031204:Caloric Restriction; D004032:Diet; D038441:Diet, Mediterranean; D004815:Epidermal Growth Factor / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007770:L-Lactate Dehydrogenase / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D011446:Prospective Studies; D015431:Weight Loss
chemical_list: D054392:Adipokines; D015415:Biomarkers; D007328:Insulin; D020738:Leptin; D004815:Epidermal Growth Factor; D007770:L-Lactate Dehydrogenase
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