title: Studies of a prototype linear stationary x-ray source for tomosynthesis imaging.
abstract: A prototype linear x-ray source to implement stationary source-stationary detector tomosynthesis (TS) imaging has been studied. Potential applications include human breast and small animal imaging. The source is comprised of ten x-ray source elements each consisting of a field emission cathode, electrostatic lens, and target. The electrostatic lens and target are common to all elements. The source elements form x-ray focal spots with minimum diameters of 0.3-0.4 mm at electron beam currents of up to 40 mA with a beam voltage of 40 kV. The x-ray flux versus time was quantified from each source. X-ray bremsstrahlung spectra from tungsten targets were produced using electron beam energies from 35 to 50 keV. The half-value layer was measured to be 0.8, 0.9, and 1.0 mm, respectively, for the 35, 40, and 45 kV tube potentials using the tungsten target. The suppression of voltage breakdown events, particularly during source operation, and the use of a modified form of the standard cold-cathode geometry, enhanced source reliability. The prototype linear source was used to collect tomographic data sets of a mouse phantom using digital TS reconstruction methods and demonstrated a slice-sensitivity profile with a full-width-half-maximum of 1.3 mm. Lastly, preliminary studies of tomographic imaging of flow through the mouse phantom were performed.
authors.affiliation: SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Schwoebel
authors.forename: John M
authors.initials: JM
authors.lastname: Boone
authors.forename: Joe
authors.initials: J
authors.lastname: Shao
mesh_terms: D000818:Animals; D004583:Electrons; D051379:Mice; D019047:Phantoms, Imaging; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014965:X-Rays
references.citation: Med Phys. 2013 Feb;40(2):021907
references.pmid: 23387755
references.citation: Radiology. 2003 Aug;228(2):352-60
references.pmid: 12893897
references.citation: Nanotechnology. 2009 Aug 12;20(32):325707
references.pmid: 19620758
references.citation: Med Phys. 2012 Dec;39(12):7254-61
references.pmid: 23231276
references.citation: Med Phys. 2012 Aug;39(8):4669-78
references.pmid: 22894391
references.citation: Med Phys. 2006 Jun;33(6):1695-706
references.pmid: 16872077
references.citation: Med Phys. 2011 Oct;38(10):5500-8
references.pmid: 21992368
references.citation: Med Phys. 2013 Feb;40(2):021909
references.pmid: 23387757
references.citation: Med Phys. 2013 Mar;40(3):031917
references.pmid: 23464332
references.citation: Med Phys. 2005 Jun;32(6):1775-84
references.pmid: 16013735
references.citation: Neoplasia. 2000 Jan-Apr;2(1-2):62-70
references.pmid: 10933069
references.citation: Comput Med Imaging Graph. 2008 Apr;32(3):239-50
references.pmid: 18243656
references.citation: Clin Radiol. 2012 Mar;67(3):232-8
references.pmid: 21939964
references.citation: Radiology. 1997 Nov;205(2):399-406
references.pmid: 9356620
references.citation: Med Phys. 2012 Apr;39(4):2090-9
references.pmid: 22482630
references.citation: Med Phys. 2013 Jan;40(1):014301
references.pmid: 23298126
references.citation: Proc SPIE Int Soc Opt Eng. 2011 Mar 3;7961:
references.pmid: 21617760
references.citation: Phys Med Biol. 2015 Jan 7;60(1):81-100
references.pmid: 25478786
references.citation: Med Phys. 2010 Jan;37(1):54-62
references.pmid: 20175466
references.citation: Med Phys. 2009 May;36(5):1624-36
references.pmid: 19544779
references.citation: Clin Radiol. 2013 May;68(5):e225-36
references.pmid: 23465326
references.citation: Med Phys. 2013 Mar;40(3):031904
references.pmid: 23464319