title: Acute generalized exanthematous pustulosis induced by piroxicam: a case report.
abstract: Acute generalized exanthematous pustulosis (AGEP) is a severe adverse cutaneous reaction characterized by an acute episode of sterile pustules over erythematous-edematous skin. The main triggering drugs are antibiotics, mainly beta-lactam and macrolides. Non-steroid anti-inflammatory drugs may rarely be responsible. We describe a case of a woman with AGEP, who presented with generalized pustulosis lesions after the use of piroxicam for renal colic. The diagnosis was confirmed by the clinical and histological correlations and the dermatosis resolved after withdrawal of the drug.
authors.affiliation: Department of Internal Medicine, Hedi Chaker University Hospital, Sfax, Tunisia.
authors.forename: Y
authors.initials: Y
authors.lastname: Cherif
authors.affiliation: Department of Internal Medicine, Hedi Chaker University Hospital, Sfax, Tunisia.
authors.forename: Moez
authors.initials: M
authors.lastname: Jallouli
authors.affiliation: Department of Dermatology, Hedi Chaker University Hospital, Sfax, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Mseddi
authors.affiliation: Department of Dermatology, Hedi Chaker University Hospital, Sfax, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Turki
authors.affiliation: Department of Internal Medicine, Hedi Chaker University Hospital, Sfax, Tunisia.
authors.forename: Z
authors.initials: Z
authors.lastname: Bahloul
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000175:diagnosis / Q000209:etiology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010894:Piroxicam / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D056844:Renal Colic / Q000188:drug therapy; D012867:Skin / Q000187:drug effects / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam
keywords: Acute generalized exanthematous pustulosis; adverse drug reactions; piroxicam; pustulosis
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