title: A correlation study applied to biomarkers of internal and effective dose for acrylonitrile and 4-aminobiphenyl in smokers.
abstract: The urinary metabolites 2-cyanoethylmercapturic acid and 4-aminobiphenyl have been correlated with tobacco smoke exposure. Similarly, 2-cyanoethylvaline and 4-aminobiphenyl haemoglobin adducts have been used as biomarkers of effective dose for the exposure to acrylonitrile and 4-aminobiphenyl, respectively. Each pair of biomarkers is derived from the same parent chemical; however, the correlation between the urinary and the haemoglobin biomarkers has not been investigated. Using clinical study samples, we report a weak correlation between urinary and haemoglobin biomarkers due to different accumulation and elimination rates. Time course analysis showed that a reduction in exposure was paralleled by a delayed reduction in haemoglobin adducts.
authors.affiliation: Analytisch-biologisches Forschungslabor GmbH , Munich , Germany .
authors.forename: Gerhard
authors.initials: G
authors.lastname: Scherer
authors.forename: Kirk
authors.initials: K
authors.lastname: Newland
authors.forename: Ermioni
authors.initials: E
authors.lastname: Papadopoulou
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Minet
mesh_terms: D000181:Acrylonitrile / Q000652:urine*; D000328:Adult; D000611:Aminobiphenyl Compounds / Q000652:urine*; D015415:Biomarkers / Q000652:urine*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000652:urine*
chemical_list: D000611:Aminobiphenyl Compounds; D015415:Biomarkers; C006757:4-biphenylamine; D000181:Acrylonitrile
keywords: 4-aminobiphenyl; acrylonitrile; biomarkers; haemoglobin adduct
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