title: Hypoxia and tumor-associated macrophages: A deadly alliance in support of tumor progression.
abstract: Tumor-associated macrophages (TAMs) provide a significant contribution to tumor growth and metastasis. We demonstrated the existence of two main TAM subsets, differing in activation state and localization. Of these, M2-like TAMs reside in hypoxic regions of the tumor mass and can be used as targets for hypoxia tracers. This said, hypoxia does not regulate the differentiation of TAMs but finely tunes the activity of the M2-like population.
authors.affiliation: Lab of Cellular and Molecular Immunology; Vrije Universiteit Brussel; Brussels, Belgium ; Myeloid Cell Immunology Lab; VIB; Brussels, Belgium.
authors.forename: Eva
authors.initials: E
authors.lastname: Van Overmeire
authors.affiliation: Lab of Cellular and Molecular Immunology; Vrije Universiteit Brussel; Brussels, Belgium ; Myeloid Cell Immunology Lab; VIB; Brussels, Belgium.
authors.forename: Damya
authors.initials: D
authors.lastname: Laoui
authors.affiliation: Lab of Cellular and Molecular Immunology; Vrije Universiteit Brussel; Brussels, Belgium ; Myeloid Cell Immunology Lab; VIB; Brussels, Belgium.
authors.forename: Jiri
authors.initials: J
authors.lastname: Keirsse
authors.affiliation: Lab of Cellular and Molecular Immunology; Vrije Universiteit Brussel; Brussels, Belgium ; Myeloid Cell Immunology Lab; VIB; Brussels, Belgium.
authors.forename: Jo A
authors.initials: JA
authors.lastname: Van Ginderachter
keywords: CD206; M1; M2; PHD2; hypoxia; molecular imaging; nanobody; tumor-associated macrophage
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