title: The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1.
abstract: RNA polymerase II carboxyl-terminal domain (pol II CTD) phosphatases are a newly emerging family of phosphatases that are members of DXDX (T/V). The subfamily includes Small CTD phosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 and UBLCP. Extensive study of SCP1 has elicited the diversified roles of the small C terminal domain phosphatase. The SCP1 plays a vital role in various biological activities, like neuronal gene silencing and preferential Ser5 dephosphorylation, acts as a cardiac hypertrophy inducer with the help of its intronic miRNAs, and has shown a key role in cell cycle regulation. This short review offers an explanation of the mechanism of action of small CTD phosphatases, in different biological activities and metabolic processes.
authors.affiliation: Departments of Applied Biochemistry Research Center, Konkuk University, Chungju 380-701, Korea.
authors.forename: Harikrishna Reddy
authors.initials: HR
authors.lastname: R
authors.affiliation: Departments of Applied Biochemistry Research Center, Konkuk University, Chungju 380-701, Korea.
authors.forename: Hackyoung
authors.initials: H
authors.lastname: Kim
authors.affiliation: Departments of Nanotechnology Research Center, Konkuk University, Chungju 380-701, Korea.
authors.forename: Kwangmo
authors.initials: K
authors.lastname: Noh
authors.affiliation: Departments of Applied Biochemistry and Nanotechnology Research Center, Konkuk University, Chungju 380-701, Korea.
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D012319:RNA Polymerase II / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D012319:RNA Polymerase II; D010749:Phosphoprotein Phosphatases; C116022:carboxy-terminal domain phosphatase
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