title: Cardiovascular risk markers and thyroid status in young Indian women with polycystic ovarian syndrome: a case-control study.
abstract: OBJECTIVE
  To study thyroid function profile, atherogenic markers and their association in young women with PCOS.
  
  
  METHODS
  Thirty women aged 15-30 years with PCOS (married and unmarried) and an equal number of age-matched controls were included in this study. The following parameters were assessed: thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), tetraiodothyronine (FT4), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C) homocysteine (HCY), lipoprotein(a) (Lp[a]) levels.
  
  
  RESULTS
  Thyroid function tests were within normal ranges in all the cases and controls. The following parameters were significantly elevated in women with PCOS compared to controls: serum TC, TG, LDL,VLDL, HCY and Lp(a). Married women with PCOS had significantly higher levels of TC, TG, VLDL-C, LDL-C, HCY and Lp(a). Among unmarried PCOS cases, HCY levels were found to be significantly higher compared to unmarried controls. In group 1, Lp(a) levels were found to be high. In group 2, TC, TG, LDL-C, VLDL-C, Lp(a) and HCY levels were found to be high. In group 3, TC, VLDL-C and Lp(a) were found to be high.
  
  
  CONCLUSIONS
  Alteration in lipid metabolism and elevated HCY and Lp(a) levels were present in women with PCOS, which were independent of their thyroid status. Unmarried PCOS women are predisposed to develop cardiovascular diseases rather than married PCOS women. Group 2 PCOS women are predisposed to get cardiovascular diseases rather than group 1 and group 3. PCOS women need not have hypothyroidism.
authors.affiliation: Department of Biochemistry, JIPMER, Puducherry, India.
authors.forename: Perla
authors.initials: P
authors.lastname: Sravan Kumar
authors.forename: Palghat Hariharan
authors.initials: PH
authors.lastname: Ananthanarayanan
authors.forename: Soundravally
authors.initials: S
authors.lastname: Rajendiran
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000503:physiopathology; D012306:Risk; D013961:Thyroid Gland / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D008055:Lipids; D017270:Lipoprotein(a); D006710:Homocysteine
keywords: atherogenic markers; homocysteine; lipid profile; polycystic ovarian syndrome; thyroid profile