title: Osseointegration of dental implants in 3D-printed synthetic onlay grafts customized according to bone metabolic activity in recipient site.
abstract: Onlay grafts made of monolithic microporous monetite bioresorbable bioceramics have the capacity to conduct bone augmentation. However, there is heterogeneity in the graft behaviour in vivo that seems to correlate with the host anatomy. In this study, we sought to investigate the metabolic activity of the regenerated bone in monolithic monetite onlays by using positron emission tomography-computed tomography (PET-CT) in rats. This information was used to optimize the design of monetite onlays with different macroporous architecture that were then fabricated using a 3D-printing technique. In vivo, bone augmentation was attempted with these customized onlays in rabbits. PET-CT findings demonstrated that bone metabolism in the calvarial bone showed higher activity in the inferior and lateral areas of the onlays. Histological observations revealed higher bone volume (up to 47%), less heterogeneity and more implant osseointegration (up to 38%) in the augmented bone with the customized monetite onlays. Our results demonstrated for the first time that it is possible to achieve osseointegration of dental implants in bone augmented with 3D-printed synthetic onlays. It was also observed that designing the macropore geometry according to the bone metabolic activity was a key parameter in increasing the volume of bone augmented within monetite onlays.
authors.affiliation: Faculty of Dentistry, McGill University, 3640 University Street, Montreal, H3A 2B2 QC, Canada. Electronic address: faleh.tamimimarino@mcgill.ca.
authors.forename: Faleh
authors.initials: F
authors.lastname: Tamimi
authors.affiliation: Faculty of Dentistry, Universidad Complutense de Madrid, Spain.
authors.forename: Jesus
authors.initials: J
authors.lastname: Torres
authors.affiliation: Faculty of Dentistry, McGill University, 3640 University Street, Montreal, H3A 2B2 QC, Canada.
authors.forename: Khadijeh
authors.initials: K
authors.lastname: Al-Abedalla
authors.affiliation: Department of Physical Chemistry II, Universidad Complutense de Madrid, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Lopez-Cabarcos
authors.affiliation: Department of Physical Chemistry II, Universidad Complutense de Madrid, Spain.
authors.forename: Mohammad H
authors.initials: MH
authors.lastname: Alkhraisat
authors.affiliation: Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: David C
authors.initials: DC
authors.lastname: Bassett
authors.affiliation: Department of Functional Materials in Medicine and Dentistry, University of Würzburg, Würzburg, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Gbureck
authors.affiliation: Faculty of Dentistry, McGill University, 3640 University Street, Montreal, H3A 2B2 QC, Canada.
authors.forename: Jake E
authors.initials: JE
authors.lastname: Barralet
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods; D000818:Animals; D001842:Bone and Bones / Q000502:physiology / Q000601:surgery; D002130:Calcium Phosphates / Q000737:chemistry; D015921:Dental Implants; D005260:Female; D007284:Inlays / Q000379:methods*; D016348:Osseointegration / Q000502:physiology*; D049268:Positron-Emission Tomography; D066330:Printing, Three-Dimensional; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; D015921:Dental Implants
keywords: Bone graft; Calcium phosphate; Dental implant; Osseointegration; Porosity