title: [Retrospective analysis of influence of differential protein intake on renal prognosis for progressive chronic kidney disease].
abstract: OBJECTIVE
  To explore retrospectively the influence of differential protein intake on renal prognosis for progressive chronic kidney disease (CKD).
  
  
  METHODS
  A total of 159 chronic kidney disease patients at stages 2, 3 and 4 were enrolled and a questionnaire survey was conducted from January 2009 to July 2012. They were followed monthly and their clinical data collected, including primary disease, blood pressure, body mass index and adverse events. Laboratory tests were performed every 3 months, including biochemical parameters, protein-energy malnutrition (PEM), diet reviews and daily protein intake (DPI). A simplified MDRD formula was employed to evaluate the level of estimated glomerular filtration rate (eGFR). According to the level of DPI, they were divided into 3 groups of very low protein diet (VLPD): DPI ≤ 0.6 g · kg(-1) · d(-1), low-protein diet (LPD): DPI >0.6-<0.8 g · kg(-1) · d(-1) and normal-protein diet (NPD): DPI ≥ 0.8 · g · kg(-1) · d(-1).
  
  
  RESULTS
  Among them, 4 cases (2.50%) progressed to uremia stage and received renal replacement therapy, 2(1.25%) experienced rapid decline in renal function, 9(5.66%) were hospitalized from cardio-cerebral diseases and the 2-year kidney survival rate was 97.5%. At the end of study, among 9 patients of PEM, 2 subjects had a serum level of albumin under 32 g/L and another 7 with a BMI<20 kg/m(2). No significant difference existed in PEM among different stages of CKD. There was no significant correlation between DPI and Δ GFR (all P > 0.05).
  
  
  CONCLUSIONS
  Within a certain range, differential protein intake may not significantly affect the prognosis of kidney for progressive CKD patients.
authors.affiliation: Department of Nephrology, Beijing Friendship Hospital & Faculty of Kidney Diseases, Capital Medical University, Beijing 100050, China.
authors.forename: Wendi
authors.initials: W
authors.lastname: Dai
authors.affiliation: Department of Nephrology, Beijing Friendship Hospital & Faculty of Kidney Diseases, Capital Medical University, Beijing 100050, China.
authors.forename: Daoxin
authors.initials: D
authors.lastname: Yin
authors.affiliation: Department of Nephrology, Beijing Friendship Hospital & Faculty of Kidney Diseases, Capital Medical University, Beijing 100050, China.
authors.forename: Wenying
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Nephrology, Beijing Friendship Hospital & Faculty of Kidney Diseases, Capital Medical University, Beijing 100050, China. Email: liuwh2002@yahoo.cn.
authors.forename: Wenhu
authors.initials: W
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D018753:Diet, Protein-Restricted / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011502:Protein-Energy Malnutrition / Q000209:etiology; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology*; D012189:Retrospective Studies