title: Effects of mitomycin-C on tear film, corneal biomechanics, and surface irregularity in mild to moderate myopic surface ablation: preliminary results.
abstract: OBJECTIVE
  To assess the effect of mitomycin-C (MMC) on the tear film, corneal biomechanics, and surface irregularity in surface ablation (photorefractive keratectomy [PRK]) for low to moderate myopia.
  
  
  METHODS
  Refractive Surgery Unit, Farabi Eye Hospital, Tehran, Iran.
  
  
  METHODS
  Double-masked randomized clinical trial.
  
  
  METHODS
  In patients with spherical equivalent myopia of -0.75 to -3.87 diopters (D) and astigmatism up to -1.75 D, the first eye was randomly assigned to the application of MMC 0.02% or a balanced salt solution for 15 seconds. The fellow eye received the alternate in a masked fashion after excimer photoablation.
  
  
  RESULTS
  The study enrolled 60 patients. In fellow eyes, the changes in the tear-film index were comparable 1 month and 6 months postoperatively. There was no significant difference in changes in total higher-order aberrations, spherical aberration, coma, or Q values (Pentacam HR) between fellow eyes at 1 month and 6 months. There was a trend toward a higher asymmetry index at 1 month; however, a statistically significant drop was observed at 6 months in the MMC group (P<.01). It was hypothesized that stromal remodeling was delayed, but better, in MMC-treated eyes. No haze was recorded at 6 months in either group.
  
  
  CONCLUSIONS
  Use of MMC in PRK did not appear to contribute significantly to surface irregularity, transient tear-film dysfunction, or biomechanical weakening of the cornea compared with PRK without MMC.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From Tehran University of Medical Sciences, International Campus (Ashrafi), the Eye Research Center (Mohammadi, Ashrafi, Norouzi, Mir-AbouTalebi, Jabbarvand), Farabi Eye Hospital, Tehran University of Medical Sciences, and the Noor Ophthalmology Research Center (Abdolahinia), Noor Eye Hospital, Tehran, Iran.
authors.forename: Seyed-Farzad
authors.initials: SF
authors.lastname: Mohammadi
authors.affiliation: From Tehran University of Medical Sciences, International Campus (Ashrafi), the Eye Research Center (Mohammadi, Ashrafi, Norouzi, Mir-AbouTalebi, Jabbarvand), Farabi Eye Hospital, Tehran University of Medical Sciences, and the Noor Ophthalmology Research Center (Abdolahinia), Noor Eye Hospital, Tehran, Iran. Electronic address: el.ashrafi@gmail.com.
authors.forename: Elham
authors.initials: E
authors.lastname: Ashrafi
authors.affiliation: From Tehran University of Medical Sciences, International Campus (Ashrafi), the Eye Research Center (Mohammadi, Ashrafi, Norouzi, Mir-AbouTalebi, Jabbarvand), Farabi Eye Hospital, Tehran University of Medical Sciences, and the Noor Ophthalmology Research Center (Abdolahinia), Noor Eye Hospital, Tehran, Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Norouzi
authors.affiliation: From Tehran University of Medical Sciences, International Campus (Ashrafi), the Eye Research Center (Mohammadi, Ashrafi, Norouzi, Mir-AbouTalebi, Jabbarvand), Farabi Eye Hospital, Tehran University of Medical Sciences, and the Noor Ophthalmology Research Center (Abdolahinia), Noor Eye Hospital, Tehran, Iran.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Abdolahinia
authors.affiliation: From Tehran University of Medical Sciences, International Campus (Ashrafi), the Eye Research Center (Mohammadi, Ashrafi, Norouzi, Mir-AbouTalebi, Jabbarvand), Farabi Eye Hospital, Tehran University of Medical Sciences, and the Noor Ophthalmology Research Center (Abdolahinia), Noor Eye Hospital, Tehran, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Mir-AbouTalebi
authors.affiliation: From Tehran University of Medical Sciences, International Campus (Ashrafi), the Eye Research Center (Mohammadi, Ashrafi, Norouzi, Mir-AbouTalebi, Jabbarvand), Farabi Eye Hospital, Tehran University of Medical Sciences, and the Noor Ophthalmology Research Center (Abdolahinia), Noor Eye Hospital, Tehran, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Jabbarvand
mesh_terms: D000328:Adult; D000477:Alkylating Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001696:Biomechanical Phenomena / Q000187:drug effects; D003315:Cornea / Q000187:drug effects* / Q000503:physiopathology*; D004311:Double-Blind Method; D004548:Elasticity / Q000187:drug effects; D005260:Female; D006801:Humans; D054018:Lasers, Excimer / Q000627:therapeutic use; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage* / Q000009:adverse effects; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D018903:Photorefractive Keratectomy / Q000379:methods*; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D013666:Tears / Q000502:physiology*; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin