title: Nutrients affecting gastric barrier.
abstract: The gastric barrier could be considered an active tissue involved in many synthetic and metabolic functions, as the immunological defense, by activating mucosal immune system. Barrier integrity results from a balance between protective and aggressive endogenous factors and from their interaction with exogenous factors (steroidal or nonsteroidal anti-inflammatory drugs, dietary nitrates, nitrites and/or NaCl, stress, Helicobacter pylori infection, food allergens and contaminants, metals, chemicals, radiation, smoking and alcohol intake). Nutrients represent the most important exogenous factors affecting gastric barrier because of the impact on people's everyday life. We report evidence from the literature about nutrients affecting gastric barrier and we investigate the possible effect that nutrients can play to determining or maintaining a gastric barrier dysfunction.
authors.affiliation: Gastroenterology, Gemelli University Hospital, Catholic University, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasbarrini
authors.forename: Francesca
authors.initials: F
authors.lastname: D'Aversa
authors.forename: Teresa
authors.initials: T
authors.lastname: Di Rienzo
authors.forename: Francesco
authors.initials: F
authors.lastname: Franceschi
mesh_terms: D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D005502:Food / Q000009:adverse effects*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D017136:Ion Transport