title: Characterization and antibacterial properties of genipin-crosslinked chitosan/poly(ethylene glycol)/ZnO/Ag nanocomposites.
abstract: Novel nanocomposites consisting of genipin-crosslinked chitosan (GC), poly(ethylene glycol) (PEG), zinc oxide (ZnO), and silver (Ag) nanoparticles were prepared for biomedical applications as the wound-healing materials. Various amounts of ZnO and Ag nanoparticles were dispersed in the GC/PEG hydrogel matrix without severe aggregation. The effects of composition and ZnO nanoparticles on the physico-chemical properties of nanocomposite samples were evaluated by infrared analysis, X-ray diffraction, and scanning electron microscopy. GC/PEG/ZnO/Ag nanocomposite showed the pH-sensitive swelling behavior and the improved mechanical properties. The antibacterial activities of nanocomposite films were tested toward the bacterial species Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis. GC/PEG/ZnO/Ag composite films had higher antibacterial activities than GC/PEG and GC/PEG/ZnO nanocomposite films. GC/PEG/ZnO/Ag composite films have potential application as wound and burn dressings.
authors.affiliation: Department of Industrial Chemistry, Chungnam National University, Daejeon 305-764, Republic of Korea.
authors.forename: Yangshuo
authors.initials: Y
authors.lastname: Liu
authors.forename: Hyung-Il
authors.initials: HI
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D001419:Bacteria / Q000254:growth & development; D001458:Bandages; D048271:Chitosan / Q000737:chemistry*; D039823:Iridoids / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D039823:Iridoids; D012834:Silver; D011092:Polyethylene Glycols; D048271:Chitosan; C007834:genipin; D015034:Zinc Oxide