title: Association analysis between the OPG g.27667T>A genetic variant and bone mineral density in Chinese postmenopausal women.
abstract: The purpose of this study was to investigate the association of the g.27667T>A genetic variant in the osteoprotegerin (OPG) gene with bone mineral density (BMD) and osteoporosis. A total of 393 primary osteoporosis subjects and 402 healthy controls were recruited. The BMD of the femoral neck hip, lumbar spine (L2-4), and total hip were evaluated by Norland XR-46 dual-energy X-ray absorptiometry. The g.27667T>A genetic variant was genotyped using created restriction site-polymerase chain reaction. Our data indicated significant differences in BMD of the femoral neck hip, lumbar spine (L2-4), and total hip among different genotypes. Individuals with the genotype TT had significantly higher BMDs than those of genotypes TA and AA (P<0.05). Results from this study suggest that the g.27667T>A genetic variant in the OPG gene is potentially related to BMD and osteoporosis in Chinese postmenopausal women.
authors.affiliation: Department of Orthopedics, The Wuxi People's Hospital, Wuxi, Jiangsu Province, China jijun_zhao@sina.cn.
authors.forename: J J
authors.initials: JJ
authors.lastname: Zhao
authors.affiliation: Department of Orthopedics, The Wuxi People's Hospital, Wuxi, Jiangsu Province, China.
authors.forename: D H
authors.initials: DH
authors.lastname: Feng
authors.affiliation: Department of Orthopedics, The Wuxi People's Hospital, Wuxi, Jiangsu Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Orthopedics, The Wuxi People's Hospital, Wuxi, Jiangsu Province, China.
authors.forename: T
authors.initials: T
authors.lastname: Lu
authors.affiliation: Department of Orthopedics, The Wuxi People's Hospital, Wuxi, Jiangsu Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Wang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D015519:Bone Density / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D053244:Osteoprotegerin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause
chemical_list: D053244:Osteoprotegerin