title: Docetaxel-induced palmoplantar erythrodysesthesia syndrome and long-lasting multiple nail changes.
abstract: Palmoplantar erythrodysesthesia syndrome (PPES) and nail changes are common presentations of cutaneous toxicity of docetaxel chemotherapy, which deteriorate the quality of life of patients. Herein, we describe a female patient who developed PPES and multiple nail changes due to docetaxel treatment for infiltrative ductal carcinoma. Cold application and elevation of extremities during docetaxel infusion, potent topical steroids and oral pyridoxine increased the tolerance to chemotherapy and provided regression of painful cutaneous lesions without cessation of the treatment.
authors.affiliation: Dermatology Clinic, Ankara Halil Sivgin Cubuk State Hospital, Ankara, Turkey.
authors.forename: Gulsen
authors.initials: G
authors.lastname: Akoglu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy / Q000473:pathology; D000077143:Docetaxel; D005260:Female; D060831:Hand-Foot Syndrome / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D054039:Onycholysis / Q000139:chemically induced* / Q000175:diagnosis; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel
keywords: Chemotherapy; docetaxel; nail; palmoplantar erythrodysesthesia syndrome
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