title: A masked diboron in Cu-catalysed borylation reaction: highly regioselective formal hydroboration of alkynes for synthesis of branched alkenylborons.
abstract: The use of a masked diboron as a boron source in the presence of a Cu-N-heterocyclic carbene (NHC) catalyst enables alkyl-, aryl-, heteroatom- and silyl-substituted terminal alkynes to undergo α-selective formal hydroboration to give diverse branched alkenylboron compounds exclusively. Synthetic potential of this α-selective hydroboration has been demonstrated by total synthesis of pharmaceutically significant bexarotene and LG100268.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527, Japan. yhiroto@hiroshima-u.ac.jp.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Yoshida
authors.forename: Yuki
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Ken
authors.initials: K
authors.lastname: Takaki