title: Periodontitis in cardiovascular disease patients with or without Marfan syndrome--a possible role of Prevotella intermedia.
abstract: BACKGROUND
  Although periodontitis is a risk factor for cardiovascular disease (CVD), the influence of periodontitis on Marfan syndrome (MFS) with CVD is unclear. The aim of this study was to assess the relationship between periodontal bacterial burden and MSF with CVD.
  
  
  RESULTS
  The subjects were patients with MFS with CVD (n = 47); age and gender matched non-MFS CVD patients (n = 48) were employed as controls. Full-mouth clinical measurements, including number of teeth, probing of pocket depth (PD), bleeding on probing (BOP) and community periodontal index (CPI) were recorded. We also evaluated the existence of three periodontal pathogens, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Prevotella intermedia using polymerase chain reaction assays. Serum antibody titers against the pathogens were also measured. We revealed that MFS with CVD patients had periodontitis more frequently than the age and gender matched non-MFS CVD control subjects. MFS with CVD patients had significantly severer periodontitis, fewer remaining teeth and deeper PD compared to the non-MFS CVD controls. Furthermore, the serum antibody titer level against Prevotella intermedia was significantly lower in MFS plus CVD patients compared to the non-MFS CVD patients.
  
  
  CONCLUSIONS
  Periodontitis may influence the pathophysiology of cardiovascular complications in MFS patients. A specific periodontal pathogen might be a crucial therapeutic target to prevent CVD development.
authors.affiliation: Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Bunkyo, Tokyo, Japan.
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Suzuki
authors.affiliation: Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Imai
authors.affiliation: Department of Cardiovascular Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan.
authors.forename: Mieko
authors.initials: M
authors.lastname: Aoki
authors.affiliation: Department of Cardiovascular Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan.
authors.forename: Daishi
authors.initials: D
authors.lastname: Fujita
authors.affiliation: Department of Periodontology, Tokyo Medical and Dental University, Bunkyo, Tokyo, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Aoyama
authors.affiliation: Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Bunkyo, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tada
authors.affiliation: Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Bunkyo, Tokyo, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Wakayama
authors.affiliation: Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Bunkyo, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akazawa
authors.affiliation: Department of Periodontology, Tokyo Medical and Dental University, Bunkyo, Tokyo, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Izumi
authors.affiliation: Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Bunkyo, Tokyo, Japan.
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Isobe
authors.affiliation: Department of Cardiovascular Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan.
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
authors.affiliation: Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
authors.affiliation: Tokyo Teishin Hospital, Chiyoda, Tokyo, Japan.
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Hirata
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D016866:Bacteroidaceae Infections / Q000276:immunology / Q000382:microbiology; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000150:complications*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010518:Periodontitis / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D018713:Prevotella intermedia / Q000235:genetics / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein
references.citation: Annu Rev Med. 2008;59:43-59
references.pmid: 17845137
references.citation: J Med Genet. 2010 Jul;47(7):476-85
references.pmid: 20591885
references.citation: J Exp Zool B Mol Dev Evol. 2009 Jul 15;312B(5):503-9
references.pmid: 19199346
references.citation: J Am Geriatr Soc. 2013 Nov;61(11):2027-37
references.pmid: 24219205
references.citation: J Periodontal Res. 2012 Aug;47(4):463-9
references.pmid: 22181324
references.citation: J Periodontal Res. 2013 Dec;48(6):687-95
references.pmid: 23441850
references.citation: FEMS Immunol Med Microbiol. 2011 Jun;62(1):91-100
references.pmid: 21314733
references.citation: Cerebrovasc Dis. 2012;34(5-6):385-92
references.pmid: 23207319
references.citation: Circ J. 2013;77(6):1565-73
references.pmid: 23412709
references.citation: Lancet. 2005 Dec 3;366(9501):1965-76
references.pmid: 16325700
references.citation: J Periodontol. 2013 Apr;84(4):545-55
references.pmid: 22769443
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 May;93(5):564-72
references.pmid: 12075206
references.citation: Heart Vessels. 2014 Jul;29(4):478-85
references.pmid: 23852405
references.citation: J Am Acad Nurse Pract. 2009 Dec;21(12):663-70
references.pmid: 19958417