title: Type 2 diabetes, PUFAs, and vitamin D: their relation to inflammation.
abstract: Chronic diseases have become one of the most important public health problems, due to their high costs for treatment and prevention. Until now, researchers have considered that the etiology of Type 2 diabetes mellitus (T2DM) is multifactorial. Recently, the study of the innate immune system has offered an explanation model of the pathogenesis of T2DM. On the other hand, there is evidence about the beneficial effect of polyunsaturated fatty acids (PUFA) n-3 and n-6 in patients with chronic inflammatory diseases including diabetes. Furthermore, high vitamin D plasmatic concentrations have been associated with the best performance of pancreatic β cells and the improving of this disease. In conclusion, certain fatty acids in the adequate proportion as well as 25-hydroxivitamin D can modulate the inflammatory response in diabetic people, modifying the evolution of this disease.
authors.affiliation: Center for Research and Graduate Studies in Health Sciences, Faculty of Medicine, Autonomous University of the State of Mexico, Paseo Tollocan Esquina, Jesús Carranza, Col. Moderna de la Cruz Toluca, 50180 México, MEX, Mexico.
authors.forename: Ana L
authors.initials: AL
authors.lastname: Guadarrama-López
authors.affiliation: Center for Research and Graduate Studies in Health Sciences, Faculty of Medicine, Autonomous University of the State of Mexico, Paseo Tollocan Esquina, Jesús Carranza, Col. Moderna de la Cruz Toluca, 50180 México, MEX, Mexico.
authors.forename: Roxana
authors.initials: R
authors.lastname: Valdés-Ramos
authors.affiliation: Center for Research and Graduate Studies in Health Sciences, Faculty of Medicine, Autonomous University of the State of Mexico, Paseo Tollocan Esquina, Jesús Carranza, Col. Moderna de la Cruz Toluca, 50180 México, MEX, Mexico.
authors.forename: Beatríz E
authors.initials: BE
authors.lastname: Martínez-Carrillo
mesh_terms: D054392:Adipokines / Q000097:blood / Q000235:genetics; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D015870:Gene Expression; D006801:Humans; D007113:Immunity, Innate; D054795:Incretins / Q000097:blood / Q000235:genetics; D007249:Inflammation / Q000097:blood / Q000235:genetics / Q000276:immunology / Q000473:pathology; D007328:Insulin / Q000097:blood; D050417:Insulin-Secreting Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D054795:Incretins; D007328:Insulin; D014807:Vitamin D; C104450:25-hydroxyvitamin D
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