title: Viral respiratory infections diagnosed by multiplex PCR after allogeneic hematopoietic stem cell transplantation: long-term incidence and outcome.
abstract: Viral respiratory infections (VRIs) are frequent after hematopoietic stem cell transplantation and constitute a potential cause of mortality. We analyzed the incidence, risk factors, and prognosis of VRIs in a cohort of transplanted patients. More frequent viruses were human coronavirus and human rhinovirus followed by flu-like viruses and adenovirus. Risk factors for death were lymphocytopenia and high steroid dosage.
authors.affiliation: Service d'Hématologie Greffe, Hôpital Saint Louis, APHP, Paris, France. INSERM U 11 60, Université Paris VII Denis Diderot, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Wolfromm
authors.affiliation: Teams Methods, Epidemiology and Statistics Sorbonne Paris Cité Research Centre UMR 1153, INSERM, Paris Descartes University. APHP, Hôtel Dieu, Centre d'Epidémiologie Clinique, Paris, France.
authors.forename: Raphael
authors.initials: R
authors.lastname: Porcher
authors.affiliation: Laboratoire de Virologie, Hôpital Saint Louis, APHP, Paris, France.
authors.forename: Jérome
authors.initials: J
authors.lastname: Legoff
authors.affiliation: Service d'Hématologie Greffe, Hôpital Saint Louis, APHP, Paris, France. INSERM U 11 60, Université Paris VII Denis Diderot, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Peffault de Latour
authors.affiliation: Service d'Hématologie Greffe, Hôpital Saint Louis, APHP, Paris, France. INSERM U 11 60, Université Paris VII Denis Diderot, France.
authors.forename: Aliénor
authors.initials: A
authors.lastname: Xhaard
authors.affiliation: Service d'Hématologie Greffe, Hôpital Saint Louis, APHP, Paris, France. INSERM U 11 60, Université Paris VII Denis Diderot, France.
authors.forename: Flore Sicre
authors.initials: FS
authors.lastname: de Fontbrune
authors.affiliation: Service d'Hématologie Greffe, Hôpital Saint Louis, APHP, Paris, France. INSERM U 11 60, Université Paris VII Denis Diderot, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Ribaud
authors.affiliation: Service de Pneumologie, Hôpital Saint Louis, APHP, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Bergeron
authors.affiliation: Service d'Hématologie Greffe, Hôpital Saint Louis, APHP, Paris, France. INSERM U 11 60, Université Paris VII Denis Diderot, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Socié
authors.affiliation: Service d'Hématologie Greffe, Hôpital Saint Louis, APHP, Paris, France. INSERM U 11 60, Université Paris VII Denis Diderot, France. Electronic address: marie.robin@sls.aphp.fr.
authors.forename: Marie
authors.initials: M
authors.lastname: Robin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D060885:Multiplex Polymerase Chain Reaction / Q000379:methods*; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000209:etiology / Q000821:virology; D019172:Transplantation Conditioning / Q000009:adverse effects* / Q000401:mortality; D014184:Transplantation, Homologous / Q000009:adverse effects* / Q000401:mortality; D016896:Treatment Outcome; D055815:Young Adult
keywords: Allogeneic hematopoietic stem cell transplantation; Respiratory viral infections
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