title: Anti-citrullinated protein antibody-positive rheumatoid arthritis associated with RS3PE syndrome-like symptoms and an elevated serum vascular endothelial growth factor level in a patient with myasthenia gravis.
abstract: A 73-year-old man with a history of myasthenia gravis (MG) was diagnosed with rheumatoid arthritis (RA) based on a history of polyarthritis and positivity for anti-citrullinated protein antibodies (ACPA). He presented with a high level of serum vascular endothelial growth factor (VEGF) and RS3PE syndrome-like pitting edema in the extremities, which improved following treatment with low-dose prednisolone. This is an interesting case of ACPA-positive RA associated with RS3PE syndrome-like pitting edema and a high VEGF level.
authors.affiliation: Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University, Graduate School of Biomedical Sciences, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Horai
authors.forename: Mai
authors.initials: M
authors.lastname: Honda
authors.forename: Ayako
authors.initials: A
authors.lastname: Nishino
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Takahisa
authors.initials: T
authors.lastname: Suzuki
authors.forename: Shin-Ya
authors.initials: SY
authors.lastname: Kawashiri
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Ichinose
authors.forename: Mami
authors.initials: M
authors.lastname: Tamai
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Motomura
authors.forename: Tomoki
authors.initials: T
authors.lastname: Origuchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D003937:Diagnosis, Differential; D004487:Edema / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000453:epidemiology*; D011239:Prednisolone / Q000627:therapeutic use; D013577:Syndrome; D013585:Synovitis / Q000175:diagnosis / Q000453:epidemiology*; D042442:Vascular Endothelial Growth Factors / Q000097:blood
chemical_list: D042442:Vascular Endothelial Growth Factors; D011239:Prednisolone