title: Cellular communication via microparticles: role in transfer of multidrug resistance in cancer.
abstract: Multidrug resistance (MDR) continues to be a major impediment to the successful treatment of cancer. The two efflux transporters, P-glycoprotein (P-gp) and MRP1 are major contributors to cancer MDR clinically. The upregulation of P-gp leading to MDR was initially understood to occur via pre- and post-transcriptional mechanisms only. However, we demonstrated that microparticles mediate the intercellular exchange and trafficking of bioactive material, including functional P-gp and selected modulatory miRNAs. This exchange of P-gp leads to the dissemination of MDR within a cancer cell population. These findings have significant implications in understanding the cellular basis governing the intercellular acquisition of deleterious traits in cancers, serving to substantially advance our understanding of the molecular basis of the emergence of MDR in cancer clinically.
authors.affiliation: School of Pharmacy, Graduate School of Health, The University of Technology, Sydney, NSW 2007, Australia.
authors.forename: Ritu
authors.initials: R
authors.lastname: Jaiswal
authors.forename: Georges Emile
authors.initials: GE
authors.lastname: Raymond Grau
authors.forename: Mary
authors.initials: M
authors.lastname: Bebawy
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002450:Cell Communication; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D010641:Phenotype; D021381:Protein Transport
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D000970:Antineoplastic Agents; D027425:ATP-Binding Cassette, Sub-Family C Proteins