title: Synthesis, characterization, antimicrobial, DNA cleavage, and in vitro cytotoxic studies of some metal complexes of schiff base ligand derived from thiazole and quinoline moiety.
abstract: A novel Schiff base ligand N-(4-phenylthiazol-2yl)-2-((2-thiaxo-1,2-dihydroquinolin-3-yl)methylene)hydrazinecarboxamide (L) obtained by the condensation of N-(4-phenylthiazol-2-yl)hydrazinecarboxamide with 2-thioxo-1,2-dihydroquinoline-3-carbaldehyde and its newly synthesized Cu(II), Co(II), Ni(II), and Zn(II) complexes have been characterized by elemental analysis and various spectral studies like FT-IR, (1)H NMR, ESI mass, UV-Visible, ESR, TGA/DTA, and powder X-ray diffraction studies. The Schiff base ligand (L) behaves as tridentate ONS donor and forms the complexes of type [ML(Cl)2] with square pyramidal geometry. The Schiff base ligand (L) and its metal complexes have been screened in vitro for their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleavage activity of ligand and its metal complexes were studied using plasmid DNA pBR322 as a target molecule by gel electrophoresis method. The brine shrimp bioassay was also carried out to study the in vitro cytotoxicity properties for the ligand and its metal complexes against Artemia salina. The results showed that the biological activities of the ligand were found to be increased on complexation.
authors.affiliation: Department of Studies and Research in Chemistry, Gulbarga University, GULBARGA, Karnataka 585 106, India.
authors.forename: Nagesh Gunvanthrao
authors.initials: NG
authors.lastname: Yernale
authors.affiliation: Department of Studies and Research in Chemistry, Gulbarga University, GULBARGA, Karnataka 585 106, India.
authors.forename: Mruthyunjayaswamy
authors.initials: M
authors.lastname: Bennikallu Hire Mathada
references.citation: Planta Med. 1982 May;45(1):31-4
references.pmid: 7100305
references.citation: J Med Chem. 2000 Nov 30;43(24):4667-77
references.pmid: 11101358
references.citation: Bioorg Med Chem. 2006 May 15;14(10):3592-8
references.pmid: 16458522
references.citation: Bioinorg Chem Appl. 2006;:83131
references.pmid: 17497020
references.citation: SAR QSAR Environ Res. 2005 Jun;16(3):219-30
references.pmid: 15804810
references.citation: Spectrochim Acta A Mol Biomol Spectrosc. 2002 Oct;58(12):2651-7
references.pmid: 12396048
references.citation: J Med Chem. 2001 Jun 7;44(12):1986-92
references.pmid: 11384243
references.citation: Eur J Med Chem. 2003 Mar;38(3):313-8
references.pmid: 12667698
references.citation: J Med Chem. 1966 Jul;9(4):545-51
references.pmid: 5968020
references.citation: Bioorg Med Chem Lett. 2006 Feb;16(3):649-53
references.pmid: 16257205
references.citation: J Med Chem. 2002 Aug 1;45(16):3531-9
references.pmid: 12139464
references.citation: Bioorg Med Chem. 2006 May 1;14(9):3098-105
references.pmid: 16412647
references.citation: Spectrochim Acta A Mol Biomol Spectrosc. 2011 Jan;78(1):337-42
references.pmid: 21094079
references.citation: J Med Chem. 1970 Jul;13(4):786
references.pmid: 5452461
references.citation: Bioorg Med Chem. 2005 Jul 15;13(14):4458-66
references.pmid: 15878667
references.citation: Biol Pharm Bull. 2004 Oct;27(10):1683-7
references.pmid: 15467220
references.citation: Spectrochim Acta A Mol Biomol Spectrosc. 2004 Oct;60(12):2861-73
references.pmid: 15350923
references.citation: Eur J Med Chem. 2001 Sep;36(9):743-6
references.pmid: 11672884
references.citation: Bioorg Med Chem Lett. 2012 Oct 15;22(20):6318-23
references.pmid: 22995621
references.citation: Bioorg Med Chem. 2010 May 15;18(10):3551-8
references.pmid: 20403703