title: Correlation between both morphologic and functional changes and anxiety in Alzheimer's disease.
abstract: BACKGROUND
  Although anxiety symptoms are often observed in Alzheimer's disease (AD), little attention has been paid to this symptom compared with other neuropsychiatric symptoms.
  
  
  METHODS
  Twenty-six patients with mild AD underwent both magnetic resonance imaging and single photon emission tomography with technetium-99m ethyl cysteinate dimer. Neuropsychiatric symptoms were evaluated using the Behavioral Pathology in Alzheimer's Disease Scale (Behave-AD). We investigated the relationship between anxiety and neuroimaging using Statistical Parametric Mapping 8 software.
  
  
  RESULTS
  The Behave-AD anxiety score was correlated with hyperperfusion in the bilateral anterior cingulate cortices and a reduction in the gray matter volume in the right precuneus and inferior parietal lobule.
  
  
  CONCLUSIONS
  Our results suggest that anxiety in AD could overlap with the neural correlates of anxiety disorders, and that the specific degeneration associated with AD might be associated with anxiety.
authors.affiliation: Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Tagai
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Nagata
authors.forename: Shunichiro
authors.initials: S
authors.lastname: Shinagawa
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nemoto
authors.forename: Keisuke
authors.initials: K
authors.lastname: Inamura
authors.forename: Norifumi
authors.initials: N
authors.lastname: Tsuno
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakayama
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000473:pathology / Q000523:psychology; D001007:Anxiety / Q000000981:diagnostic imaging* / Q000473:pathology / Q000523:psychology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D015331:Cohort Studies; D003553:Cystine / Q000031:analogs & derivatives; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging* / Q000473:pathology; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging; D009483:Neuropsychological Tests; D009929:Organ Size; D015609:Organotechnetium Compounds; D010296:Parietal Lobe / Q000000981:diagnostic imaging* / Q000473:pathology; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C541351:ethyl cysteinate dimer; D003553:Cystine