title: Corneal backscatter analysis by in vivo confocal microscopy: fellow eye comparison of small incision lenticule extraction and femtosecond laser-assisted LASIK.
abstract: Purpose. To evaluate and compare corneal backscatter from anterior stroma between small incision lenticule extraction (SMILE) and femtosecond laser-assisted LASIK (femto-LASIK). Methods. A cohort of 60 eyes of 30 patients was randomized to receive SMILE in one eye and femto-LASIK in the fellow eye. In vivo confocal microscopy was performed at 1 week and 1, 3, and 6 months after surgery. The main outcome measurements were maximum backscattered intensity and the depth from which it was measured, the backscattered light intensity 30  μ m below Bowman's membrane at the flap interface and 150  μ m below the superficial epithelium, and the number of refractive particles at the flap interface. Results. The mean backscattered light intensity (LI) at all measured depths and the maximum backscattered LI were higher in the SMILE group than the femto-LASIK group at all postoperative visits. LI differences at 1 week and 1- and 3-month visits were statistically significant (P < 0,05). LI differences at 6 months were not statistically significant. There was no difference in the number of refractive particles at the flap interface between the groups at any visit. Conclusions. SMILE results in increased backscattered LI in the anterior stroma when compared with femto-LASIK were evaluated.
authors.affiliation: Beyoglu Eye Research and Training Hospital, 34421 Istanbul, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Agca
authors.affiliation: Beyoglu Eye Research and Training Hospital, 34421 Istanbul, Turkey.
authors.forename: Engin Bilge
authors.initials: EB
authors.lastname: Ozgurhan
authors.affiliation: Beyoglu Eye Research and Training Hospital, 34421 Istanbul, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yildirim
authors.affiliation: Beyoglu Eye Research and Training Hospital, 34421 Istanbul, Turkey.
authors.forename: Kadir Ilker
authors.initials: KI
authors.lastname: Cankaya
authors.affiliation: Beyoglu Eye Research and Training Hospital, 34421 Istanbul, Turkey.
authors.forename: Nimet Burcu
authors.initials: NB
authors.lastname: Guleryuz
authors.affiliation: Beyoglu Eye Research and Training Hospital, 34421 Istanbul, Turkey.
authors.forename: Zeynep
authors.identifier: 0000-0002-5363-1944
authors.initials: Z
authors.lastname: Alkin
authors.affiliation: Beyoglu Eye Research and Training Hospital, 34421 Istanbul, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ozkaya
authors.affiliation: Department of Ophthalmology, Istanbul Medeniyet University, 34730 Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demirok
authors.affiliation: Beyoglu Eye Research and Training Hospital, 34421 Istanbul, Turkey.
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Yilmaz
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