title: Feasibility of Early and Repeated Low-dose Interscalene Brachial Plexus Block for Residual Pain in Acute Cervical Radiculopathy Treated with NSAIDS.
abstract: BACKGROUND
  To improve residual pain management in acute cervical radiculopathy treated with NSAIDs, the feasibility of early and repeated low-dose interscalene brachial plexus block (IS-BPB) needs to be assessed.
  
  
  METHODS
  This was a prospective study on patients receiving NSAIDs (loxoprofen) for cervical radiculopathy of ≤ 2-week onset. Pain was assessed using the visual analogue scale (VAS). A low-dose ultrasonography (USG)-guided IS-BPB (dexamethasone [1.65 mg; 0.5 ml] and mepivacaine [1%; 3.0 ml]) was performed at baseline and weekly thereafter for 4 weeks in an outpatient setting for the intervention group. All patients were evaluated using a visual satisfaction score (VSS) at week 4. Patients with baseline VAS scores < 70 (mild to moderate pain; MM group) and ≥ 70 (severe pain; SE group) were compared to the controls receiving NSAIDs.
  
  
  RESULTS
  A total of 316 IS-BPBs were performed in the intervention group. There was a significant difference in the decline in the VAS from week 0 to week 3 in the MM and SE groups (P < 0.05); however, from week 3 to week 4, the therapeutic effect exhibited no significant difference. Thirteen patients at week 2 (15.5%; MM: 27.7%; SE: 0%), 43 at week 3 (51.2%; MM: 83.0%; SE: 10.8%), and 47 at week 4 (56.0%; MM: 85.1%; SE: 18.9%) achieved a VAS score of ≤ 20. Patient satisfaction was high, and the decrease in VAS scores in both groups was significant (P < 0.05) compared to the controls.
  
  
  CONCLUSIONS
  Weekly, low-dose, USG-guided IS-BPB can be implemented for early pain relief in acute cervical radiculopathy, with high patient satisfaction.
authors.affiliation: Department of Anesthesiology, Nara Prefectural Mimuro Hospital, Nara, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Iwata
authors.affiliation: Department of Anesthesiology, Nara Prefectural Mimuro Hospital, Nara, Japan. ; Department of Anesthesiology, Heisei Memorial Hospital, Nara, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Mitoro
authors.affiliation: Department of Anesthesiology, Nara Prefectural Mimuro Hospital, Nara, Japan. ; Department of Anesthesiology, Nara Prefectural Nara Hospital, Nara, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Kuzumoto
keywords: acute; brachial plexus; cervical radiculopathy; low-dose; nerve block
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