title: Synthesis of reboxetine intermediate and carnitine acetyltransferase inhibitor via NBS-induced electrophilic multicomponent reaction.
abstract: N-Bromosuccinimide-induced electrophilic multicomponent reaction has been applied to the synthesis of Reboxetine intermediate, a highly potent selective norepinephrine reuptake inhibitor. By simply changing the olefinic partner, the synthesis of a carnitine acetyltransferase inhibitor, which contains a 2,6,6-trisubstituted morpholine system, can be accomplished.
authors.affiliation: Department of Chemistry, National University of Singapore , 3 Science Drive 3, Singapore 117543.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Ying-Yeung
authors.initials: YY
authors.lastname: Yeung
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D001974:Bromosuccinimide / Q000737:chemistry*; D002332:Carnitine O-Acetyltransferase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D009025:Morpholines / Q000138:chemical synthesis* / Q000737:chemistry; D009638:Norepinephrine / Q000737:chemistry* / Q000494:pharmacology*; D000077593:Reboxetine
chemical_list: D018759:Adrenergic Uptake Inhibitors; D004791:Enzyme Inhibitors; D009025:Morpholines; C037574:morpholine; D000077593:Reboxetine; D002332:Carnitine O-Acetyltransferase; D001974:Bromosuccinimide; D009638:Norepinephrine