title: The protective effects of Shen-Fu injection on experimental acute pancreatitis in a rat model.
abstract: OBJECTIVE
  In the present study, we investigated the protective effects of Shen-Fu injection (SFI) on a caerulein-induced rat pancreatitis (AP) model.
  
  
  METHODS
  SFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies.
  
  
  RESULTS
  Our results showed that AP caused significant decrease in tissue glutathione (GSH) and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA) and myeloperoxidase (MPO) were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein.
  
  
  CONCLUSIONS
  Our findings suggest that the SFI protects against caerulein-induced AP in rats via modulation of cytokines, oxidative stress, and Nuclear Factor-kappa B (NF-κB) activity.
authors.affiliation: Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang, Wuhan, Hubei 430071, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of General Surgery, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang, Wuhan, Hubei 430071, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
mesh_terms: D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism; D007267:Injections; D008049:Lipase / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism / Q000473:pathology; D010195:Pancreatitis / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy*; D009195:Peroxidase / Q000378:metabolism; D020011:Protective Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D051996:Transcription Factor RelA / Q000378:metabolism
chemical_list: D016207:Cytokines; D004365:Drugs, Chinese Herbal; D020011:Protective Agents; C492793:Shen-Fu; D051996:Transcription Factor RelA; D008315:Malondialdehyde; D009195:Peroxidase; D008049:Lipase; D000681:Amylases; D005978:Glutathione
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