title: Molecular mechanisms in autoimmune type 1 diabetes: a critical review.
abstract: Autoimmune type 1 diabetes is characterized by selective destruction of insulin-secreting beta cells in the pancreas of genetically susceptible individuals. The mechanisms underlying the development of type 1 diabetes are not fully understood. However, a widely accepted point is that type 1 diabetes is caused by a combination of genetic and environmental factors. Although most type 1 diabetes patients do not have a family history, genetic susceptibility does play a vital role in beta cell autoimmunity and destruction. Human leukocyte antigen (HLA) regions are the strongest genetic determinants, which can contribute 40-50 % of the genetic risk to type 1 diabetes. Other genes, including INS also contribute to disease risk. The mechanisms of the susceptible genes in type 1 diabetes may relate to their respective roles in antigen presentation, beta cell autoimmunity, immune tolerance, and autoreactive T cell response. Environmental susceptibility factors also contribute to the risk of developing type 1 diabetes. From an epigenetic standpoint, the pathologic mechanisms involved in the development of type 1 diabetes may include DNA methylation, histone modification, microRNA, and molecular mimicry. These mechanisms may act through regulating of gene expression, thereby affecting the immune system response toward islet beta cells. One of the characteristics of type 1 diabetes is the recognition of islet autoantigens by autoreactive CD4(+) and CD8(+) T cells and autoantibodies. Autoantibodies against islet autoantigens are involved in autoantigen processing and presentation by HLA molecules. This review will mainly focus on the molecular mechanism by which genetic, epigenetic, and environmental factors contribute to the risk of type 1 diabetes.
authors.affiliation: Diabetes Center, 2nd Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, Hunan, 410011, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Xie
authors.forename: Christopher
authors.initials: C
authors.lastname: Chang
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D017951:Antigen Presentation; D001323:Autoantibodies / Q000096:biosynthesis; D001324:Autoantigens / Q000235:genetics / Q000276:immunology; D015551:Autoimmunity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D044127:Epigenesis, Genetic / Q000276:immunology*; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D050417:Insulin-Secreting Cells / Q000276:immunology* / Q000473:pathology; D018716:Molecular Mimicry
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D006680:HLA Antigens
references.citation: J Autoimmun. 2009 May-Jun;32(3-4):189-94
references.pmid: 19303254
references.citation: J Epidemiol Community Health. 2012 Jun;66(6):479-81
references.pmid: 21502091
references.citation: J Autoimmun. 2007 Jun;28(4):177-87
references.pmid: 17320348
references.citation: J Autoimmun. 2013 Aug;44:82-90
references.pmid: 23895744
references.citation: Genes Immun. 2011 Apr;12(3):208-12
references.pmid: 21270831
references.citation: Diabetologia. 2013 Sep 11;:
references.pmid: 24022707
references.citation: J Autoimmun. 2014 May;50:77-82
references.pmid: 24387802
references.citation: Nat Genet. 2010 Jan;42(1):68-71
references.pmid: 19966805
references.citation: Clin Exp Immunol. 2009 Apr;156(1):12-6
references.pmid: 19220326
references.citation: Diabetes Res Clin Pract. 2009 Dec;86(3):e54-7
references.pmid: 19815302
references.citation: J Clin Endocrinol Metab. 2006 May;91(5):1654-9
references.pmid: 16478821
references.citation: Physiol Rev. 2011 Jan;91(1):79-118
references.pmid: 21248163
references.citation: Eur J Immunogenet. 2003 Dec;30(6):401-7
references.pmid: 14675393
references.citation: Diabetes Care. 2003 Feb;26(2):452-7
references.pmid: 12547879
references.citation: Am J Hum Genet. 1996 Nov;59(5):1134-48
references.pmid: 8900244
references.citation: Nat Rev Genet. 2005 Aug;6(8):597-610
references.pmid: 16136652
references.citation: Lancet. 2000 Mar 11;355(9207):873-6
references.pmid: 10752702
references.citation: Lancet. 2014 Jan 4;383(9911):69-82
references.pmid: 23890997
references.citation: Diabetologia. 2005 Aug;48(8):1435-8
references.pmid: 16021415
references.citation: Diabetologia. 1992 May;35(5):419-24
references.pmid: 1521722
references.citation: Nature. 2007 Dec 6;450(7171):887-92
references.pmid: 18004301
references.citation: J Autoimmun. 2013 Mar;41:50-9
references.pmid: 23490285
references.citation: Nature. 2010 Sep 23;467(7314):460-4
references.pmid: 20827270
references.citation: Front Microbiol. 2011 Sep 05;2:180
references.pmid: 21922015
references.citation: BMC Med Genomics. 2010 Aug 05;3:33
references.pmid: 20687937
references.citation: Nat Genet. 2009 Jun;41(6):703-7
references.pmid: 19430480
references.citation: Diabetes Care. 2008 Mar;31(3):534-8
references.pmid: 18056891
references.citation: Diabetes. 2010 Jan;59(1):302-10
references.pmid: 19833889
references.citation: Acta Diabetol. 2012 Oct;49(5):327-31
references.pmid: 20473693
references.citation: Diabetologia. 2011 Aug;54(8):2033-7
references.pmid: 21559886
references.citation: Diabetologia. 2005 Nov;48(11):2195-9
references.pmid: 16193287
references.citation: Lancet. 2009 Jun 13;373(9680):1999-2000
references.pmid: 19481250
references.citation: Genes Immun. 2012 Jan;13(1):66-70
references.pmid: 21850031
references.citation: Diabetes Obes Metab. 2009 Feb;11 Suppl 1:31-45
references.pmid: 19143813
references.citation: Diabetes. 2006 Jun;55(6):1890-4
references.pmid: 16731859
references.citation: Diabetes. 2004 Jul;53(7):1884-9
references.pmid: 15220214
references.citation: J Clin Endocrinol Metab. 2001 Aug;86(8):3705-10
references.pmid: 11502799
references.citation: Diabet Med. 2012 Jun;29(6):761-6
references.pmid: 22133003
references.citation: Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19018-23
references.pmid: 22074781
references.citation: Diabetes. 2013 Feb;62(2):543-50
references.pmid: 23086039
references.citation: Diabetes. 2008 May;57(5):1433-7
references.pmid: 18310307
references.citation: Clin Rev Allergy Immunol. 2014 Oct;47(2):128-35
references.pmid: 24362548
references.citation: Curr Opin Endocrinol Diabetes Obes. 2012 Apr;19(2):73-80
references.pmid: 22357099
references.citation: J Autoimmun. 2013 Jun;43:78-84
references.pmid: 23623029
references.citation: PLoS Genet. 2011 Sep;7(9):e1002293
references.pmid: 21980299
references.citation: Diabetes. 2011 Nov;60(11):3081-4
references.pmid: 22025780
references.citation: Biochem Biophys Res Commun. 2005 Dec 2;337(4):1308-18
references.pmid: 16236267
references.citation: Clin Rev Allergy Immunol. 2012 Feb;42(1):5-15
references.pmid: 22090147
references.citation: Discov Med. 2011 Dec;12(67):535-45
references.pmid: 22204770
references.citation: Autoimmun Rev. 2013 Jun;12(8):814-20
references.pmid: 23219952
references.citation: Diabetes. 2011 Oct;60(10):2645-53
references.pmid: 21873553
references.citation: Intern Med. 2012;51(24):3391-4
references.pmid: 23257526
references.citation: Nat Genet. 2005 Dec;37(12):1317-9
references.pmid: 16273109
references.citation: Science. 2011 Sep 2;333(6047):1303-7
references.pmid: 21817016
references.citation: Autoimmunity. 2008 Feb;41(1):11-8
references.pmid: 18176860
references.citation: Diabetes Metab Res Rev. 2011 Nov;27(8):862-6
references.pmid: 22069274
references.citation: Nature. 2003 May 29;423(6939):506-11
references.pmid: 12724780
references.citation: J Immunol Methods. 2009 May 15;344(1):79-83
references.pmid: 19328805
references.citation: Diabetologia. 2001 Mar;44(3):354-62
references.pmid: 11317668
references.citation: Diabetes. 2010 Jul;59(7):1561-71
references.pmid: 20587799
references.citation: Diabetes. 2008 Apr;57(4):1143-6
references.pmid: 18198356
references.citation: Hum Immunol. 1998 Dec;59(12):794-801
references.pmid: 9831135
references.citation: Cold Spring Harb Perspect Med. 2012 Apr;2(4):a007781
references.pmid: 22474615
references.citation: Am J Clin Nutr. 2010 May;91(5):1506S-1513S
references.pmid: 20335552
references.citation: Ann N Y Acad Sci. 2008 Dec;1150:93-8
references.pmid: 19120275
references.citation: J Autoimmun. 2013 Mar;41:25-33
references.pmid: 23395425
references.citation: Eur J Epidemiol. 2004;19(10):931-4
references.pmid: 15575351
references.citation: Nat Genet. 1995 Mar;9(3):284-92
references.pmid: 7773291
references.citation: Nat Genet. 2007 Sep;39(9):1074-82
references.pmid: 17676041
references.citation: PLoS Genet. 2011 Sep;7(9):e1002300
references.pmid: 21980303
references.citation: J Autoimmun. 2013 Sep;45:68-79
references.pmid: 23871638
references.citation: Diabetologia. 2005 Nov;48(11):2206-12
references.pmid: 16193284
references.citation: J Autoimmun. 2013 Aug;44:40-8
references.pmid: 23770292
references.citation: Hum Mol Genet. 1996 Jul;5(7):1075-80
references.pmid: 8817351
references.citation: Diabetologia. 1988 Oct;31(10):747-50
references.pmid: 3240835
references.citation: Autoimmun Rev. 2013 Sep;12(11):1046-51
references.pmid: 23684698
references.citation: Nat Biotechnol. 2010 Oct;28(10):1057-68
references.pmid: 20944598
references.citation: Nature. 1999 Oct 28;401(6756):921-3
references.pmid: 10553908
references.citation: Diabetes. 2012 Aug;61(8):1907-14
references.pmid: 22826307
references.citation: Diabetologia. 2003 Mar;46(3):420-5
references.pmid: 12687342
references.citation: Diabetes. 2005 Dec;54 Suppl 2:S125-36
references.pmid: 16306330
references.citation: Diabetes. 1986 Feb;35(2):237-41
references.pmid: 3510930
references.citation: Hum Immunol. 1995 Dec;44(4):210-9
references.pmid: 8770634
references.citation: Immunity. 2010 Apr 23;32(4):457-67
references.pmid: 20412756
references.citation: Genes Immun. 2009 Dec;10 Suppl 1:S85-94
references.pmid: 19956107
references.citation: Diabetes. 2010 Dec;59(12):3174-80
references.pmid: 20858685
references.citation: PLoS One. 2012;7(5):e36278
references.pmid: 22567146
references.citation: Environ Health Perspect. 2001 Dec;109 Suppl 6:871-6
references.pmid: 11744505
references.citation: J Pediatr Endocrinol Metab. 2007 Sep;20(9):981-7
references.pmid: 18038707
references.citation: Autoimmun Rev. 2013 May;12(7):758-67
references.pmid: 23340277
references.citation: Diabetologia. 2001 Oct;44 Suppl 3:B75-80
references.pmid: 11724421
references.citation: J Autoimmun. 2013 Mar;41:1-5
references.pmid: 23375849
references.citation: Diabetes. 2005 Dec;54 Suppl 2:S52-61
references.pmid: 16306341
references.citation: J Exp Med. 2005 Nov 7;202(9):1191-7
references.pmid: 16260488
references.citation: J Autoimmun. 1996 Jun;9(3):379-83
references.pmid: 8816974
references.citation: Diabetes. 2011 Mar;60(3):1041-4
references.pmid: 21270240
references.citation: Clin Rev Allergy Immunol. 2000 Dec;19(3):247-64
references.pmid: 11138408
references.citation: Immunol Today. 1996 Jul;17(7):323-9
references.pmid: 8763818
references.citation: Am J Transl Res. 2013 May 24;5(4):379-92
references.pmid: 23724162
references.citation: Autoimmun Rev. 2008 Jul;7(7):550-7
references.pmid: 18625444
references.citation: Am J Epidemiol. 2009 Jun 15;169(12):1428-36
references.pmid: 19363100
references.citation: Mol Pathol. 2003 Feb;56(1):1-10
references.pmid: 12560454
references.citation: Endocrinol Metab Clin North Am. 2010 Sep;39(3):481-97
references.pmid: 20723815
references.citation: Science. 2008 Oct 10;322(5899):271-5
references.pmid: 18845758
references.citation: Ann N Y Acad Sci. 2008 Dec;1150:99-102
references.pmid: 19120276
references.citation: Diabetes Care. 2003 Jul;26(7):2223; author reply 2224
references.pmid: 12832355
references.citation: Am J Clin Nutr. 2003 Dec;78(6):1053-67
references.pmid: 14668264
references.citation: Diabetes. 1998 Dec;47(12):1971-3
references.pmid: 9836533
references.citation: Nat Genet. 1997 Mar;15(3):289-92
references.pmid: 9054944
references.citation: BMJ. 2011 Feb 03;342:d35
references.pmid: 21292721
references.citation: Transl Res. 2011 Apr;157(4):163-79
references.pmid: 21420027
references.citation: Curr Opin Endocrinol Diabetes Obes. 2012 Aug;19(4):263-70
references.pmid: 22732486
references.citation: Adv Gerontol. 2010;23(2):243-8
references.pmid: 21033293
references.citation: Hum Mol Genet. 2010 Jun 15;19(12):2534-8
references.pmid: 20378605
references.citation: J Med Genet. 2009 Aug;46(8):553-4
references.pmid: 19465406
references.citation: Eur J Immunol. 2005 Jul;35(7):2157-62
references.pmid: 15940668
references.citation: Lancet. 1974 Nov 30;2(7892):1279-83
references.pmid: 4139522
references.citation: Biol Chem. 2009 Nov;390(11):1145-53
references.pmid: 19747081
references.citation: Exp Diabetes Res. 2012;2012:896362
references.pmid: 22829805
references.citation: Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3988-91
references.pmid: 11274421
references.citation: Clin Rev Allergy Immunol. 2012 Feb;42(1):102-11
references.pmid: 22095454
references.citation: N Engl J Med. 2008 Dec 25;359(26):2767-77
references.pmid: 19073967
references.citation: Neuroimmunomodulation. 2006;13(5-6):301-8
references.pmid: 17709952
references.citation: APMIS. 2012 Dec;120(12):941-9
references.pmid: 23051179
references.citation: Genes Immun. 2010 Jul;11(5):432-8
references.pmid: 20535138
references.citation: Nat Genet. 2004 Aug;36(8):837-41
references.pmid: 15247916
references.citation: Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9
references.pmid: 16009939
references.citation: Nat Genet. 2005 Dec;37(12):1300-2
references.pmid: 16314859
references.citation: J Autoimmun. 2004 May;22(3):191-200
references.pmid: 15041039
references.citation: Clin Rev Allergy Immunol. 2012 Feb;42(1):1-4
references.pmid: 22187334
references.citation: Ann N Y Acad Sci. 2002 Apr;958:39-46
references.pmid: 12021082
references.citation: Diabetes. 2010 Nov;59(11):2972-9
references.pmid: 20798335
references.citation: J Clin Endocrinol Metab. 2000 Dec;85(12):4538-42
references.pmid: 11134105
references.citation: Diabetes Care. 2000 Oct;23(10):1516-26
references.pmid: 11023146
references.citation: Diabetes Metab Res Rev. 2013 Jan;29(1):8-18
references.pmid: 23180441
references.citation: Diabetes. 1999 Jan;48(1):150-7
references.pmid: 9892237
references.citation: J Immunol. 2000 May 1;164(9):4659-64
references.pmid: 10779770
references.citation: Nat Genet. 2005 Feb;37(2):110-1; author reply 112-3
references.pmid: 15678134
references.citation: J Biol Chem. 2012 May 11;287(20):16335-45
references.pmid: 22431725
references.citation: Immunol Cell Biol. 2012 Mar;90(3):271-6
references.pmid: 22290506
references.citation: Lancet. 2004 Nov 6-12;364(9446):1699-700
references.pmid: 15530631
references.citation: Diabetes. 2008 Jan;57(1):229-34
references.pmid: 17934143
references.citation: Scand J Immunol. 2009 Oct;70(4):326-36
references.pmid: 19751267
references.citation: Immunogenetics. 2006 Jun;58(5-6):331-8
references.pmid: 16552513
references.citation: Nat Genet. 1997 Mar;15(3):293-7
references.pmid: 9054945
references.citation: Nat Rev Genet. 2006 Dec;7(12):917-28
references.pmid: 17139323
references.citation: J Autoimmun. 2014 May;50:33-7
references.pmid: 24210274
references.citation: Autoimmun Rev. 2013 Aug;12(10):947-53
references.pmid: 23537508
references.citation: Diabetes. 2002 May;51(5):1346-55
references.pmid: 11978629
references.citation: Autoimmunity. 2007 Dec;40(8):582-90
references.pmid: 18075792
references.citation: J Med Virol. 2002 Mar;66(3):340-50
references.pmid: 11793386
references.citation: Diabetologia. 2008 May;51(5):769-72
references.pmid: 18278478
references.citation: J Autoimmun. 2013 Sep;45:97-103
references.pmid: 23809879
references.citation: Clin Rev Allergy Immunol. 2013 Aug;45(1):1-5
references.pmid: 23842719
references.citation: Diabetologia. 2007 Jan;50(1):68-73
references.pmid: 17143607
references.citation: Diabetes. 1997 Jan;46(1):143-9
references.pmid: 8971095
references.citation: Genes Immun. 2010 Mar;11(2):188-93
references.pmid: 20054344
references.citation: Autoimmun Rev. 2013 Aug;12(10):972-5
references.pmid: 23684702
references.citation: Br Med Bull. 2008;88(1):115-29
references.pmid: 19088009
references.citation: Pediatr Diabetes. 2011 Mar;12(2):127-32
references.pmid: 20546165
references.citation: J Clin Invest. 1994 Nov;94(5):2125-9
references.pmid: 7962558
references.citation: Science. 1983 Dec 23;222(4630):1337-9
references.pmid: 6362005
references.citation: Nat Genet. 2006 Jun;38(6):617-9
references.pmid: 16699517
references.citation: Nat Rev Genet. 2008 Feb;9(2):102-14
references.pmid: 18197166
references.citation: Endocrinology. 2013 Sep;154(9):3476-81
references.pmid: 23825129
references.citation: Nat Genet. 2008 Dec;40(12):1399-401
references.pmid: 18978792
references.citation: Diabetes. 2000 Aug;49(8):1319-24
references.pmid: 10923632
references.citation: JAMA. 2003 Oct 1;290(13):1771-2
references.pmid: 14519713
references.citation: Hum Immunol. 2001 Apr;62(4):299-309
references.pmid: 11295462
references.citation: BMC Med. 2013 Feb 21;11:46
references.pmid: 23433344
references.citation: Diabetes. 2008 Dec;57(12):3189-98
references.pmid: 18776137
references.citation: ISRN Pharmacol. 2012;2012:580202
references.pmid: 22577577
references.citation: Diabetes. 2002 Feb;51(2):545-51
references.pmid: 11812768
references.citation: Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S116-21
references.pmid: 17452059
references.citation: Autoimmun Rev. 2013 May;12(7):717-25
references.pmid: 23261816
references.citation: Diabetes. 2011 Jan;60(1):276-9
references.pmid: 20943747
references.citation: Nature. 2000 Jan 6;403(6765):41-5
references.pmid: 10638745
references.citation: Diabetologia. 1992 Nov;35(11):1060-7
references.pmid: 1473616
references.citation: Hum Genet. 2011 Feb;129(2):161-76
references.pmid: 21076979
references.citation: Nat Rev Genet. 2007 Feb;8(2):93-103
references.pmid: 17230196
references.citation: Immunol Res. 2013 Mar;55(1-3):167-72
references.pmid: 22971988
references.citation: Front Biosci. 2007 Jan 01;12:1889-98
references.pmid: 17127428
references.citation: Am J Hum Genet. 1987 Jan;40(1):1-14
references.pmid: 3468804
references.citation: Trends Mol Med. 2008 Jun;14(6):268-75
references.pmid: 18482868
references.citation: Nat Rev Genet. 2004 Dec;5(12):889-99
references.pmid: 15573121
references.citation: Am J Epidemiol. 2002 Nov 1;156(9):787-96
references.pmid: 12396995
references.citation: Diabetologia. 1999 Jan;42(1):3-14
references.pmid: 10027571
references.citation: Nat Rev Mol Cell Biol. 2010 Sep;11(9):607-20
references.pmid: 20683471
references.citation: Immunobiology. 2013 May;218(5):733-7
references.pmid: 22999472
references.citation: Blood. 1994 Dec 15;84(12):4008-27
references.pmid: 7994020
references.citation: Nat Immunol. 2008 Aug;9(8):839-45
references.pmid: 18645592
references.citation: Diabetologia. 2002 Oct;45(10):1353-61
references.pmid: 12378375
references.citation: Cell Immunol. 2010;260(2):70-4
references.pmid: 19954774
references.citation: Diabetes Care. 1998 Apr;21(4):525-9
references.pmid: 9571336
references.citation: Horm Res. 2008;69(5):284-9
references.pmid: 18259107
references.citation: Diabetologia. 2012 Apr;55(4):996-1000
references.pmid: 22278338
references.citation: Hum Immunol. 2002 Aug;63(8):657-64
references.pmid: 12121673
references.citation: J Autoimmun. 2013 Dec;47:83-93
references.pmid: 24090977
references.citation: Diabetes Care. 2010 Sep;33(9):2062-4
references.pmid: 20805278
references.citation: Cold Spring Harb Perspect Med. 2012 Jan;2(1):a007732
references.pmid: 22315720
references.citation: Tissue Antigens. 2007 Aug;70(2):110-27
references.pmid: 17610416
references.citation: Immunity. 2010 Apr 23;32(4):446-56
references.pmid: 20412755
references.citation: Diabetes. 2004 Nov;53(11):3020-3
references.pmid: 15504986
references.citation: Clin Microbiol Rev. 2002 Jul;15(3):414-29
references.pmid: 12097249
references.citation: Diabetes Metab Res Rev. 2010 Oct;26(7):579-84
references.pmid: 20842762
references.citation: Diabetes. 1973 Jun;22(6):429-32
references.pmid: 4541338
references.citation: Clin Rev Allergy Immunol. 2012 Feb;42(1):92-101
references.pmid: 22161696
references.citation: Diabetes Care. 2010 Jan;33(1):104-8
references.pmid: 19808923
references.citation: Tissue Antigens. 1999 Dec;54(6):543-51
references.pmid: 10674967
references.citation: Autoimmun Rev. 2012 Mar;11(5):305-14
references.pmid: 20627134
references.citation: Arch Med Sci. 2012 Nov 9;8(5):874-8
references.pmid: 23185198
references.citation: N Engl J Med. 1989 Apr 6;320(14):881-6
references.pmid: 2648146
references.citation: Diabetes. 2011 Jul;60(7):1825-31
references.pmid: 21709277
references.citation: Autoimmun Rev. 2013 Oct;12(12):1160-5
references.pmid: 23860189
references.citation: Diabetes. 2008 Oct;57(10):2858-61
references.pmid: 18647951
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5
references.pmid: 17942684
references.citation: Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12030-5
references.pmid: 21730150
references.citation: BMC Med Genet. 2011 Apr 27;12:59
references.pmid: 21524304
references.citation: Clin Rev Allergy Immunol. 2007 Feb;32(1):111-8
references.pmid: 17426366
references.citation: Curr Diab Rep. 2013 Oct;13(5):601-7
references.pmid: 23934614
references.citation: Genes Immun. 2009 Mar;10(2):188-91
references.pmid: 19110536
references.citation: Autoimmun Rev. 2014 Mar;13(3):266-71
references.pmid: 24189282
references.citation: Autoimmun Rev. 2013 Mar;12(5):633-7
references.pmid: 23277162
references.citation: Nat Genet. 2007 Jul;39(7):857-64
references.pmid: 17554260
references.citation: PLoS One. 2010 Nov 15;5(11):e15393
references.pmid: 21085585
references.citation: Genes Dev. 2002 Jan 1;16(1):6-21
references.pmid: 11782440
references.citation: Autoimmun Rev. 2013 Sep;12(11):1070-5
references.pmid: 23685277
references.citation: Cell. 2009 Oct 30;139(3):485-98
references.pmid: 19836068
references.citation: Chin Med J (Engl). 2009 Apr 20;122(8):980-6
references.pmid: 19493426
references.citation: Lancet. 2009 Jun 13;373(9680):2027-33
references.pmid: 19481249
references.citation: Diabetes. 2013 Feb;62(2):339-40
references.pmid: 23349539
references.citation: Diabetes. 2008 Apr;57(4):1084-92
references.pmid: 18252895
references.citation: Curr Opin Endocrinol Diabetes Obes. 2013 Aug;20(4):299-306
references.pmid: 23770733
references.citation: Autoimmun Rev. 2013 Oct;12(12):1171-6
references.pmid: 23851140
references.citation: Diabetologia. 2013 Nov;56(11):2347-54
references.pmid: 24048671
references.citation: Diabetes. 1984 Feb;33(2):176-83
references.pmid: 6363172
references.citation: Clin Rev Allergy Immunol. 2013 Oct;45(2):290-301
references.pmid: 23975606
references.citation: J Diabetes. 2011 Sep;3(3):238-47
references.pmid: 21631897
references.citation: Diabetes Care. 2000 Mar;23(3):290-4
references.pmid: 10868853
references.citation: Hum Mol Genet. 2010 May 15;19(10):2059-67
references.pmid: 20176734
references.citation: Diabetes Metab Rev. 1998 Mar;14(1):31-67
references.pmid: 9605629
references.citation: Clin Rev Allergy Immunol. 2012 Feb;42(1):58-70
references.pmid: 22116709