title: Relationship between ABO blood group and Acute Lymphoblastic Leukemia.
abstract: Acute lymphoblastic leukemia (ALL) constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. ALL affects both children and adults. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms. The aim of this study was to investigate the association between ALL and ABO blood group.
  
  
  METHODS
  This is a case-control study that was carried out in Amir Oncology Hospital in Shiraz during 2011 to2013. The case group consisted of 293 patients with acute lymphoblastic leukemia. And compared with 300 subject in control group ( the age in the case group was between 2-5 year, and the age in the control group was between 2-45 year) .Statistical analyzes was done performed by chi -square test. The results was considered significant when p value <0.05. (CI:0.95).
  
  
  RESULTS
  The ABO blood group distribution was 82(A), 59 (B), 24 (AB) and 128(O) in patient with Acute Lymphoblastic Leukemia and the blood group of 300 participants in the control group include, 63% (25) A, 69% (25.6) B, 18 % 06.8) AB and 101% (42.6) O. The ABO blood group distribution showed that there is significant differences between ABO blood group and patients with acute lymphoblastic leukemia .
  
  
  CONCLUSIONS
  This study showed significant association between ALL and ABO blood group and showed that blood group AB was associated with a higher risk of All (p value<0.001).
authors.affiliation: Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Tavasolian
authors.affiliation: Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: E
authors.initials: E
authors.lastname: Abdollahi
authors.affiliation: Department of Community Medicine, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Vakili
authors.affiliation: School of Paramedical Sciences,Shahid Sadoughi University of Medical Sciences,Yazd, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Amini
keywords: ABO blood group; Acute lymphoblastic leukemia; Children
references.citation: J Natl Cancer Inst. 2009 Mar 18;101(6):424-31
references.pmid: 19276450
references.citation: Blood. 1960 Mar;15:332-49
references.pmid: 13821951
references.citation: Ann Intern Med. 1960 May;52:1099-107
references.pmid: 14425541
references.citation: Genet Mol Res. 2008 Feb 01;7(1):87-94
references.pmid: 18273824
references.citation: J Thromb Haemost. 2008 Jan;6(1):62-9
references.pmid: 17973651
references.citation: Immunohematology. 2009;25(2):48-59
references.pmid: 19927620
references.citation: N Engl J Med. 2004 Apr 8;350(15):1535-48
references.pmid: 15071128
references.citation: Blood. 1957 Aug;12(8):683-93
references.pmid: 13445996
references.citation: J Clin Oncol. 2011 Feb 10;29(5):532-43
references.pmid: 21220592
references.citation: Biol Blood Marrow Transplant. 2009 Feb;15(2):257-65
references.pmid: 19167686
references.citation: Nat Genet. 2009 Sep;41(9):986-90
references.pmid: 19648918
references.citation: Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):2021-8
references.pmid: 22628432
references.citation: N Engl J Med. 2009 Jun 25;360(26):2730-41
references.pmid: 19553647
references.citation: Semin Hematol. 2009 Jan;46(1):24-32
references.pmid: 19100365
references.citation: Br J Haematol. 1981 Jul;48(3):507-8
references.pmid: 7259996
references.citation: Transfusion. 2010 Oct;50(10):2102-4
references.pmid: 20492611
references.citation: Eur J Cancer. 2010 Dec;46(18):3345-50
references.pmid: 20833034
references.citation: Br Med J. 1953 Apr 11;1(4814):799-801
references.pmid: 13032504