title: Alterations in amplitude of low frequency fluctuation in treatment-naïve major depressive disorder measured with resting-state fMRI.
abstract: There are limited resting-state functional magnetic resonance imaging (fMRI) studies in major depressive disorder (MDD). Of these studies, functional connectivity analyses are mostly used. However, a new method based on the magnitude of low frequency fluctuation (LFF) during resting-state fMRI may provide important insight into MDD. In this study, we examined the amplitude of LFF (ALFF) within the whole brain during resting-state fMRI in 30 treatment-naïve MDD subjects and 30 healthy control (HC) subjects. When compared with HC, MDD subjects showed increased ALFF in the frontal cortex (including the bilateral ventral/dorsal anterior cingulate cortex, orbitofrontal cortex, premotor cortex, ventral prefrontal cortex, left dorsal lateral frontal cortex, left superior frontal cortex), basal ganglia (including the right putamen and left caudate nucleus), left insular cortex, right anterior entorhinal cortex and left inferior parietal cortex, together with decreased ALFF in the bilateral occipital cortex, cerebellum hemisphere, and right superior temporal cortex. These findings may relate to characteristics of MDD, such as excessive self-referential processing and deficits in cognitive control of emotional processing, which may contribute to the persistent and recurrent nature of the disorder.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Ren
authors.forename: Fay Y
authors.initials: FY
authors.lastname: Womer
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.forename: Guoguang
authors.initials: G
authors.lastname: Fan
authors.forename: Wenyan
authors.initials: W
authors.lastname: Jiang
authors.forename: Hilary P
authors.initials: HP
authors.lastname: Blumberg
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Tang
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology*; D001931:Brain Mapping; D016009:Chi-Square Distribution; D003865:Major Depressive Disorder / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005583:Fourier Analysis; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D011569:Psychiatric Status Rating Scales; D012146:Rest; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: amplitude of low-frequency fluctuation; cerebellum; depression; prefrontal cortex; resting-state fMRI
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