title: Brain microvascular endothelial cells resist elongation due to curvature and shear stress.
abstract: The highly specialized endothelial cells in brain capillaries are a key component of the blood-brain barrier, forming a network of tight junctions that almost completely block paracellular transport. In contrast to vascular endothelial cells in other organs, we show that brain microvascular endothelial cells resist elongation in response to curvature and shear stress. Since the tight junction network is defined by endothelial cell morphology, these results suggest that there may be an evolutionary advantage to resisting elongation by minimizing the total length of cell-cell junctions per unit length of vessel.
authors.affiliation: 1] Department of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218 [2] Institute for Nanobiotechnology (INBT), Johns Hopkins University, Baltimore, Maryland 21218.
authors.forename: Mao
authors.initials: M
authors.lastname: Ye
authors.affiliation: 1] Institute for Nanobiotechnology (INBT), Johns Hopkins University, Baltimore, Maryland 21218 [2] Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218 and.
authors.forename: Henry M
authors.initials: HM
authors.lastname: Sanchez
authors.affiliation: 1] Institute for Nanobiotechnology (INBT), Johns Hopkins University, Baltimore, Maryland 21218 [2] Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218 and.
authors.forename: Margot
authors.initials: M
authors.lastname: Hultz
authors.affiliation: Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland 21218.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: 1] Institute for Nanobiotechnology (INBT), Johns Hopkins University, Baltimore, Maryland 21218 [2] Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218 and.
authors.forename: Max
authors.initials: M
authors.lastname: Bogorad
authors.affiliation: 1] Institute for Nanobiotechnology (INBT), Johns Hopkins University, Baltimore, Maryland 21218 [2] Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218 and.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Wong
authors.affiliation: 1] Department of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218 [2] Institute for Nanobiotechnology (INBT), Johns Hopkins University, Baltimore, Maryland 21218 [3] Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218 and.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Searson
mesh_terms: D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000378:metabolism*; D001921:Brain / Q000098:blood supply; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology*; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D055806:Microvessels / Q000166:cytology*; D013312:Stress, Physiological; D019108:Tight Junctions / Q000378:metabolism*
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