title: Association between serum homocysteine and arterial stiffness in elderly: a community-based study.
abstract: BACKGROUND
  Arterial stiffness and homocysteine are both powerful predictors of cardiovascular disease, especially in older populations. Previous studies have investigated the association of homocysteine with arterial stiffness in human subjects, while the relationship between homocysteine and arterial stiffness in the elderly is still indefinite. The current study examined the association of homocysteine with arterial stiffness in Chinese community-based elderly persons.
  
  
  METHODS
  We related serum levels of homocysteine to two measures of arterial stiffness (carotid-femoral pulse wave velocity (PWV) and carotid-radial PWV) in 780 participants (46.3% men, mean age 71.9 years (ranging 65-96 years old)) from two communities of Beijing, China. Arterial stiffness was measured within two days of the time of biomarker measurement.
  
  
  RESULTS
  In multiple-adjusted models, homocysteine levels were strongly associated with the carotid-femoral PWV (standardized β = 0.13, P < 0.001), even after adjustment for classical risk factors of cardiovascular disease. The association is also stronger when the carotid-femoral PWV is elevated above normal, whereas no significant association with homocysteine was observed for carotid-radial PWV.
  
  
  CONCLUSIONS
  In Chinese elderly persons, serum homocysteine levels are associated with alterations of aortic stiffness.
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, No.28, Fuxing Road, Beijing 100853, China ; School of Medicine, Nankai University, NO.94, Weijin Road, Tianjin 300071, China.
authors.forename: Song
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, No.28, Fuxing Road, Beijing 100853, China.
authors.forename: Yong-Yi
authors.initials: YY
authors.lastname: Bai
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, No.28, Fuxing Road, Beijing 100853, China.
authors.forename: Lei-Ming
authors.initials: LM
authors.lastname: Luo
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, No.28, Fuxing Road, Beijing 100853, China.
authors.forename: Wen-Kai
authors.initials: WK
authors.lastname: Xiao
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, No.28, Fuxing Road, Beijing 100853, China.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Wu
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, No.28, Fuxing Road, Beijing 100853, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
keywords: Arterial stiffness; Homocysteine; Pulse wave velocity; The elderly
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