title: Thiocarbamate-linked polysulfonate-peptide conjugates as selective hepatocyte growth factor receptor binders.
abstract: The capacity of many proteins to interact with natural or synthetic polyanions has been exploited for modulating their biological action. However, the polydispersity of these macromolecular polyanions as well as their poor specificity is a severe limitation to their use as drugs. An emerging trend in this field is the synthesis of homogeneous and well-defined polyanion-peptide conjugates, which act as bivalent ligands, with the peptide part bringing the selectivity of the scaffold. Alternately, this strategy can be used for improving the binding of short peptides to polyanion-binding protein targets. This work describes the design and first synthesis of homogeneous polysulfonate-peptide conjugates using thiocarbamate ligation for binding to the extracellular domain of MET tyrosine kinase receptor for hepatocyte growth factor.
authors.affiliation: UMR CNRS 8161 , F-59021 Lille, France.
authors.forename: Soizic
authors.initials: S
authors.lastname: Besret
authors.forename: Jérôme
authors.initials: J
authors.lastname: Vicogne
authors.forename: Fatima
authors.initials: F
authors.lastname: Dahmani
authors.forename: Véronique
authors.initials: V
authors.lastname: Fafeur
authors.forename: Rémi
authors.initials: R
authors.lastname: Desmet
authors.forename: Hervé
authors.initials: H
authors.lastname: Drobecq
authors.forename: Anthony
authors.initials: A
authors.lastname: Romieu
authors.forename: Patricia
authors.initials: P
authors.lastname: Melnyk
authors.forename: Oleg
authors.initials: O
authors.lastname: Melnyk
mesh_terms: D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D019859:Proto-Oncogene Proteins c-met / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D013451:Sulfonic Acids / Q000737:chemistry*; D013859:Thiocarbamates / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D010455:Peptides; D013451:Sulfonic Acids; D013859:Thiocarbamates; D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met
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