title: Zebrafish as a model of cardiac disease.
abstract: The zebrafish has been rapidly adopted as a model for cardiac development and disease. The transparency of the embryo, its limited requirement for active oxygen delivery, and ease of use in genetic manipulations and chemical exposure have made it a powerful alternative to rodents. Novel technologies like TALEN/CRISPR-mediated genome engineering and advanced imaging methods will only accelerate its use. Here, we give an overview of heart development and function in the fish and highlight a number of areas where it is most actively contributing to the understanding of cardiac development and disease. We also review the current state of research on a feature that we only could wish to be conserved between fish and human; cardiac regeneration.
authors.affiliation: Department of Cardiovascular Science, Medical School, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Robert N
authors.initials: RN
authors.lastname: Wilkinson
authors.affiliation: CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Département de Physiologie, Labex Ion Channel Science and Therapeutics, Montpellier, France; INSERM, U661, Montpellier, France; Universités de Montpellier 1&2, UMR-5203, Montpellier, France.
authors.forename: Chris
authors.initials: C
authors.lastname: Jopling
authors.affiliation: MRC Centre for Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Fredericus J M
authors.initials: FJ
authors.lastname: van Eeden
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D055724:Electrophysiological Phenomena; D006321:Heart / Q000196:embryology / Q000502:physiology; D006331:Heart Diseases / Q000473:pathology*; D012038:Regeneration / Q000502:physiology; D015027:Zebrafish / Q000196:embryology / Q000502:physiology*
keywords: Arrhythmia; Cardiac disease; Cardiomyopathy; Congenital heart defects; Disease model; Heart development; Heart regeneration; Zebrafish