title: Skin-homing Th2/Th22 cells in papuloerythroderma of Ofuji.
abstract: Papuloerythroderma of Ofuji (PEO) appears to be a T cell-mediated skin disease; however, the pathogenesis of PEO remains unclear. We report two cases of PEO and examine cytokine production and expression of skin-homing receptors in circulating T cells in the patients. The percentages of interleukin 4 (IL-4)-, IL-13- and IL-22-producing CD4+ and CD8+ T cells were markedly higher in the circulation of patients with PEO than in those of healthy subjects. The expression of both cutaneous lymphocyte antigen (CLA) and CC chemokine receptor 4 (CCR4) were significantly upregulated in the circulating CD4+ and CD8+ T cells. Moreover, serum levels of thymus and activation-regulated chemokine (TARC), a chemoattractant for CCR4, were increased. The number of IL-4-, IL-13- and IL-22-producing T cells, expression of CLA and CCR4 by T cells, and serum TARC levels significantly decreased after complete remission of PEO. These results suggest that skin-homing Th2/Th22 cells may play a role in the pathogenesis of PEO.
authors.affiliation: Department of Dermatology, Saitama Medical University, Saitama Medical Center, Kawagoe, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Teraki
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Inoue
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry*; D054414:Chemokine CCL17 / Q000097:blood; D003873:Dermatitis, Exfoliative / Q000097:blood / Q000276:immunology*; D006801:Humans; D018793:Interleukin-13 / Q000032:analysis; D015847:Interleukin-4 / Q000032:analysis; D007378:Interleukins / Q000032:analysis; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D054398:Receptors, CCR4 / Q000032:analysis; D017444:Skin Diseases, Papulosquamous / Q000097:blood / Q000276:immunology*; D018418:Th2 Cells / Q000737:chemistry*; D000097043:Interleukin-22
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D054414:Chemokine CCL17; D018793:Interleukin-13; D015847:Interleukin-4; D007378:Interleukins; D008562:Membrane Glycoproteins; D054398:Receptors, CCR4; D000097043:Interleukin-22; C515354:CCR4 protein, human; C063419:CTAGE1 protein, human