title: Successful treatment of pityriasis rubra pilaris with adalimumab - case report.
abstract: Pityriasis Rubra Pilaris (PRP) is an uncommon skin disorder characterized by follicular keratosis, palmoplantar keratoderma, and erythroderma. The traditional preferred treatment is oral retinoids, but over the last decade, biologic therapy with anti-TNF agents has been used with success. We report the case of a 51 year- old man with a clinical and histopathological diagnosis of PRP. He underwent therapy with adalimumab and showed clearance of skin lesions within the fourth week of treatment.
authors.affiliation: Universidad Nacional Mayor de San Marcos, Hospital Nacional "Luis N. Saenz".
authors.forename: Erick A
authors.initials: EA
authors.lastname: Bravo
authors.forename: Leonidas
authors.initials: L
authors.lastname: Carrion
authors.forename: Silvia M
authors.initials: SM
authors.lastname: Paucar
authors.forename: Rossana
authors.initials: R
authors.lastname: Mendoza
authors.forename: Carlos
authors.initials: C
authors.lastname: Rivera
mesh_terms: D000068879:Adalimumab; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010916:Pityriasis Rubra Pilaris / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D003879:Dermatologic Agents; D014409:Tumor Necrosis Factor-alpha; D000068879:Adalimumab