title: Multicystic dysplastic kidney: Impact of imaging modality selection on the initial management and prognosis.
abstract: OBJECTIVE
  To evaluate the impact of imaging modalities on the evaluation and prognosis of children with multicystic dysplastic kidney (MCDK) disease.
  
  
  METHODS
  A retrospective analysis of all children with MCDK diagnosed from 2004 until 2012 was performed. The study included 63 patients for whom all postnatal imaging modalities were available: renal bladder ultrasound (RBUS), dimercaptosuccinic acid scan (DMSA) and voiding cystourethrogram (VCUG). Cases with major congenital abnormalities or incomplete data were excluded. Abnormalities in the contralateral kidney and the fate of MCDK were also addressed.
  
  
  RESULTS
  At diagnosis, the average age was four-and-a-half months. The majority of cases were detected antenatally (87%). Postnatal RBUS and DMSA scans established the diagnosis of MCDK in 92% and 98% of patients, respectively. DMSA showed photopenic areas in the contralateral kidneys in 10% of patients; all of them had hydronephrosis and were confirmed to have vesicoureteral reflux (VUR). Contralateral VUR was detected in 16 patients; 63% of them had hydronephrosis. After a mean follow-up of three-and-a-half years, involution occurred in 62% of patients and the involution rate was inversely proportional to the initial size.
  
  
  CONCLUSIONS
  The classical appearance of MCDK on RBUS was sufficient to establish the diagnosis in most patients. DMSA scan was more accurate in confirming the diagnosis and evaluating the contralateral kidney. Selective screening for VUR in patients with contralateral hydronephrotic kidney should be considered.
authors.affiliation: Pediatric Urology Unit, Urology Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: o_sarhan2004@yahoo.com.
authors.forename: O M
authors.initials: OM
authors.lastname: Sarhan
authors.affiliation: Pediatric Urology Unit, Urology Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: alghanbar@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Alghanbar
authors.affiliation: Pediatric Urology Unit, Urology Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: aalsulihem@yahoo.com.
authors.forename: A
authors.initials: A
authors.lastname: Alsulaihim
authors.affiliation: Pediatric Urology Unit, Urology Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: dr__badr@hotmail.com.
authors.forename: B
authors.initials: B
authors.lastname: Alharbi
authors.affiliation: Pediatric Urology Unit, Urology Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: alotay99@hotmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Alotay
authors.affiliation: Pediatric Urology Unit, Urology Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: drziad@hotmail.com.
authors.forename: Z
authors.initials: Z
authors.lastname: Nakshabandi
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D021782:Multicystic Dysplastic Kidney / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D011379:Prognosis; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014463:Ultrasonography; D001743:Urinary Bladder / Q000000981:diagnostic imaging; D014567:Urography; D014718:Vesico-Ureteral Reflux / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
keywords: Antenatal diagnosis; Multicystic dysplastic kidney; Prognosis; Vesicoureteric reflux