title: Multiple cutaneous angiosarcomas after breast conserving surgery and bilateral adjuvant radiotherapy: an unusual case and review of the literature.
abstract: Breast angiosarcomas (BAs) are rare but serious events that may arise after radiation exposure. Disease outcome is poor, with high risk of local and distant failure. Recurrences are frequent also after resection with negative margins. The spectrum of vascular proliferations associated with radiotherapy in the setting of breast cancer has expanded, including radiation-associated atypical vascular lesions (AVLs) of the breast skin as a rare, but well-recognized, entity. Although pursuing a benign behavior, AVLs have been regarded as possible precursors of postradiation BAs. We report an unusual case of a 71-year-old woman affected by well-differentiated bilateral cutaneous BA, diagnosed 1.9 years after adjuvant RT for synchronous bilateral breast cancer. Whole-life clinical followup is of crucial importance in breast cancer patients.
authors.affiliation: Department of Radiation-Oncology, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy.
authors.forename: Icro
authors.initials: I
authors.lastname: Meattini
authors.affiliation: Division of Pathological Anatomy, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Santi
authors.affiliation: Department of Radiation-Oncology, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Scartoni
authors.affiliation: Department of Radiation-Oncology, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Giacomelli
authors.affiliation: Department of Radiation-Oncology, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: De Luca Cardillo
authors.affiliation: Department of Radiation-Oncology, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy.
authors.forename: Vieri
authors.initials: V
authors.lastname: Scotti
authors.affiliation: Department of Surgery, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy.
authors.forename: Donato
authors.initials: D
authors.lastname: Casella
authors.affiliation: Department of Surgery, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Simoncini
authors.affiliation: Department of Surgery, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Orzalesi
authors.affiliation: Diagnostic Senology Unit, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy.
authors.forename: Jacopo
authors.initials: J
authors.lastname: Nori
authors.affiliation: Division of Pathological Anatomy, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy.
authors.forename: Milena
authors.initials: M
authors.lastname: Paglierani
authors.affiliation: Department of Radiation-Oncology, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Livi
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