title: The Effect of Extract/Fractions ofCaralluma tuberculataon Blood Glucose Levels and Body Weight in Alloxan-Induced Diabetic Rabbits.
abstract: Caralluma tuberculatais a cooked food item in Pakistan especially for diabetics. The current study was designed to explore the antidiabetic potential of extract/fractions ofCaralluma tuberculatain alloxan-induced diabetic rabbits and its effect on body weight. The crude extract of the plant provoked 24% and 44% antidiabetic action at 25 and 50 mg/kg OP, respectively, after the 24th day of treatment, which was strongly supported by a positive effect on the body weight of animals. On fractionation, pretreatment of the ethyl acetate fraction demonstrated most dominant (25.17% and 34.83%) antidiabetic activity followed byn-hexane (19.33% and 32.76%) and aqueous fractions (16.44% and 22.36%) at 25 and 50 mg/kg OP, respectively, after the 24th day of treatment. The corresponding effect on blood glucose was also observed on body weight of diabetic rabbits. In sum, extract/fractions of the plant showed marked antidiabetic action and thus a provided scientific foundation to the use of the plant as an antidiabetic.
authors.affiliation: 1 Kohat University of Science & Technology, Kohat, Pakistan.
authors.forename: Khushbakht
authors.initials: K
authors.lastname: Sultan
authors.affiliation: 1 Kohat University of Science & Technology, Kohat, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zakir
authors.affiliation: 2 Abdul Wali Khan University, Mardan, Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.affiliation: 1 Kohat University of Science & Technology, Kohat, Pakistan.
authors.forename: Ihsaan Ullah
authors.initials: IU
authors.lastname: Khan
authors.affiliation: 1 Kohat University of Science & Technology, Kohat, Pakistan.
authors.forename: Ali
authors.initials: A
authors.lastname: Rehman
authors.affiliation: 1 Kohat University of Science & Technology, Kohat, Pakistan.
authors.forename: Noor Ul
authors.initials: NU
authors.lastname: Akber
authors.affiliation: 2 Abdul Wali Khan University, Mardan, Pakistan.
authors.forename: Naveed
authors.initials: N
authors.lastname: Muhammad
authors.affiliation: 1 Kohat University of Science & Technology, Kohat, Pakistan.
authors.forename: Murad Ali
authors.initials: MA
authors.lastname: Khan
keywords: antihyperglycemic effect; extract/fractions