title: [Regulatory T cells and aging].
abstract: Regulatory T cells with potent immunosuppressive properties have a pivotal role in the maintenance of immune homeostasis. This review highlights recent findings regarding the age-related changes in numbers and functional activity of human Treg-cells. Some of the mechanisms that keep the balance of Treg-cells during human aging are discussed. The possible roles of Treg-lymphocytes in pathogenesis of several diseases, associated with advanced age are also considered.
authors.forename: A V
authors.initials: AV
authors.lastname: Churov
mesh_terms: D000375:Aging / Q000276:immunology*; D016922:Cellular Senescence; D006801:Humans; D007108:Immune Tolerance; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*