title: Serum paraoxonase-1 enzyme activities and oxidative stress levels in patients with esophageal squamous cell carcinoma.
abstract: OBJECTIVE
  Oxidative stress is well recognized to play a role in the pathogenesis of many diseases, including cancers. Paraoxonase-1 (PON1) is implicated in the elimination of carcinogenic lipid-soluble radicals produced by lipid peroxidation. Reports on PON1 activities in patients with cancer are conflicting. The aim of this study was to investigate serum antioxidant enzyme activities and oxidative stress levels in patients with esophageal squamous cell carcinoma (ESCC).
  
  
  METHODS
  Thirty-two patients with ESCC and 33 healthy controls were enrolled. Serum malondialdehyde (MDA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione reductase (GR), paraoxonase, and arylesterase activities were measured spectrophotometrically.
  
  
  RESULTS
  Serum paraoxonase, arylesterase, SOD, activities, GSH-Px, and GR activities were significantly lower in patients with ESCC than in controls (all, P < 0.05), whereas serum MDA levels were significantly higher (P < 0.05). Serum MDA levels were significantly correlated with paraoxonase (r = -0.572, P < 0.001) and arylesterase activities (r = -0.597, P < 0.001) in patients with ESCC.
  
  
  CONCLUSIONS
  This study indicated that ESCC is associated with increased oxidative stress and decreased antioxidant enzyme activities. Decreased serum PON1 enzyme activities may play a role in the progression and/or development of ESCC. Further studies are required to clarify these results.
authors.forename: Abidin
authors.initials: A
authors.lastname: Sehitogulları
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Fuat
authors.initials: F
authors.lastname: Sayır
authors.forename: Ali
authors.initials: A
authors.lastname: Kahraman
authors.forename: Halit
authors.initials: H
authors.lastname: Demir
mesh_terms: D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D011379:Prognosis; D011446:Prospective Studies; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Esophageal squamous cell carcinoma; Glutathione peroxidase; Malondialdehyde; PON1 activity; Superoxide dismutase
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