title: Sequential intra-intercellular nanoparticle delivery system for deep tumor penetration.
abstract: To achieve deep tumor penetration of large-sized nanoparticles (NPs), we have developed a reversible swelling-shrinking nanogel in response to pH variation for a sequential intra-intercellular NP delivery. The nanogel had a crosslinked polyelectrolyte core, consisting of N-lysinal-N'-succinyl chitosan and poly(N-isopropylacrylamide), and a crosslinked bovine serum albumin shell, which was able to swell in an acidic environment and shrink back under neutral conditions. The swelling resulted in a rapid release of the encapsulated chemotherapeutics in the cancer cells for efficient cytotoxicity. After being liberated from the dead cells, the contractive nanogel could infect neighboring cancer cells closer to the center of the tumor tissue.
authors.affiliation: State Key Laboratory of Natural Medicines, Center of Drug Discovery and Department of Pharmaceutics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009 (China).
authors.forename: Caoyun
authors.initials: C
authors.lastname: Ju
authors.forename: Ran
authors.initials: R
authors.lastname: Mo
authors.forename: Jingwei
authors.initials: J
authors.lastname: Xue
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Zekai
authors.initials: Z
authors.lastname: Zhao
authors.forename: Lingjing
authors.initials: L
authors.lastname: Xue
authors.forename: Qineng
authors.initials: Q
authors.lastname: Ping
authors.forename: Can
authors.initials: C
authors.lastname: Zhang
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D053758:Nanoparticles
chemical_list: D004337:Drug Carriers
keywords: antitumor agents; drug delivery; nanogels; pH responsive; tumor penetration