title: Topical amphotericin B in combination with standard therapy for severe necrotizing skin and soft-tissue mucormycosis in an infant with bilineal leukemia: case report and review.
abstract: During chemotherapy for bilineal leukemia, a 6-month-old infant presented with a necrotizing skin and soft-tissue infection of the chest wall due to Rhizopus sp. Successful outcome was achieved by systemically administered liposomal amphotericin B and local wound control with the novel administration of topical deoxycholate amphotericin B and surgical resection.
authors.affiliation: *Department of Pediatrics, Infectious Diseases Division, Vanderbilt University, Nashville, TN Departments of †Pediatrics ‡Pediatrics, Division of Hematology-Oncology §Surgery, Alfred I. duPont Hospital for Children, Wilmington, DE ∥Transplantation-Oncology Infectious Diseases Program ¶Department of Pediatrics #Department of Microbiology & Immunology, Weill Cornell Medical Center, New York, NY.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Di Pentima
authors.forename: Shannon
authors.initials: S
authors.lastname: Chan
authors.forename: Jonathan
authors.initials: J
authors.lastname: Powell
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Napoli
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Walter
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D000287:Administration, Topical; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors*; D017809:Fatal Outcome; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male; D009091:Mucormycosis / Q000150:complications / Q000188:drug therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy*; D012233:Rhizopus / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000666:Amphotericin B