title: [Changes of blood pressure and S-100B, neuron specific enolase protein in hypertensive dogs after renal sympathetic denervation].
abstract: OBJECTIVE
  To observe the changes of blood pressure and S-100B, neuron specific enolase (NSE) protein in hypertensive dogs with high fat diet after catheter-based renal sympathetic denervation.
  
  
  METHODS
  Twelve Beagles were divided into an interventional group (n=6) and a sham-operation group (n=6). After baseline measurements, the Beagles were fed with lard oil for 3 months. After 3 months, the interventional group had renal sympathetic denervation by percutaneous catheter based radiofrequency ablation and the control group had renal angiography. The blood pressure, plasma S-100B, and NSE before the operation and 3 days, 1 week, 2 weeks, 1 month, 2 months and 3 months after the operation were measured.
  
  
  RESULTS
  The dogs had significantly higher levels of systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MBP) compared to its baselines (P<0.05). The SBP, DBP and MBP in the interventional group were significantly lower than those in the control group 1 month and 3 months after the operation (P<0.05). Three months after the operation, renal angiography in all dogs revealed no sign of renal artery stenosis. Plasma S-100B and NSE expression in the interventional group were higher than those in the control group 3 days, 1 week and 2 weeks after the operation (P<0.05).
  
  
  CONCLUSIONS
  Renal sympathetic denervation can significantly reduce the SBP, DBP and MBP in hypertensive dogs. The plasma S-100B and NSE may be used as indicators for assessment of renal nerve injury after renal sympathetic denervation.
authors.affiliation: Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Fenglin
authors.initials: F
authors.lastname: Jiang
authors.forename: Xinguo
authors.initials: X
authors.lastname: Wang
authors.forename: Fuyin
authors.initials: F
authors.lastname: Zhu
authors.forename: Lixiong
authors.initials: L
authors.lastname: Zeng
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Shen
authors.forename: Kan
authors.initials: K
authors.lastname: Yang
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001794:Blood Pressure; D017115:Catheter Ablation; D004285:Dogs; D006973:Hypertension / Q000378:metabolism*; D007668:Kidney / Q000294:innervation / Q000601:surgery; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D064568:S100 Calcium Binding Protein beta Subunit / Q000378:metabolism*; D013562:Sympathectomy
chemical_list: D064568:S100 Calcium Binding Protein beta Subunit; D010751:Phosphopyruvate Hydratase