title: Habitual consumption of coffee and green tea in relation to serum adipokines: a cross-sectional study.
abstract: OBJECTIVE
  Coffee and green tea consumption may be associated with circulating adipokines, but data are inconsistent, scarce or lacking. We examined the association of coffee and green tea consumption with serum adiponectin, leptin, visfatin, resistin and plasminogen activator inhibitor-1 (PAI-1) among a Japanese working population.
  
  
  METHODS
  The authors analyzed data (n = 509) from a cross-sectional survey among Japanese workers aged 20-68 years. Serum adipokines were measured using a Luminex suspension bead-based multiplexed array. Coffee and green tea consumption was assessed using a validated diet history questionnaire, and caffeine consumption from these beverages was estimated. Multiple regression analysis was performed with adjustment for potential confounding variables.
  
  
  RESULTS
  Coffee consumption was significantly, inversely associated with leptin and PAI-1 (P for trend = 0.007 and 0.02, respectively); compared with subjects consuming <1 cup per day, those consuming ≥4 cups per day had 13 and 10 % lower means of leptin and PAI-1, respectively. Similar associations were observed for caffeine consumption (P for trend = 0.02 for both leptin and PAI-1). Additionally, we noted a significant positive association between coffee consumption and adiponectin in men (P for trend = 0.046), but not in women (P for trend = 0.43, P for interaction = 0.11). Moreover, there was a positive association between coffee consumption and resistin in current male smokers (P for trend = 0.01), but not in male non-smokers (P for trend = 0.35, P for interaction = 0.11). Green tea consumption was not associated with any adipokine.
  
  
  CONCLUSIONS
  Higher consumption of coffee and caffeine but not green tea was associated with lower serum levels of leptin and PAI-1 in Japanese adults.
authors.affiliation: Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Toyama 1-21-1, Shinjuku-ku, Tokyo, 162-8655, Japan, minh.pn@tnu.edu.vn.
authors.forename: Ngoc Minh
authors.initials: NM
authors.lastname: Pham
authors.forename: Akiko
authors.initials: A
authors.lastname: Nanri
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yasuda
authors.forename: Kayo
authors.initials: K
authors.lastname: Kurotani
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kuwahara
authors.forename: Shamima
authors.initials: S
authors.lastname: Akter
authors.forename: Masao
authors.initials: M
authors.lastname: Sato
authors.forename: Hitomi
authors.initials: H
authors.lastname: Hayabuchi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mizoue
mesh_terms: D052242:Adiponectin / Q000819:agonists / Q000097:blood*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002110:Caffeine / Q000009:adverse effects* / Q000032:analysis; D003069:Coffee / Q000009:adverse effects* / Q000737:chemistry; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D004034:Diet Surveys; D005247:Feeding Behavior / Q000208:ethnology; D005260:Female; D005511:Food Handling; D006801:Humans; D007564:Japan; D020738:Leptin / Q000037:antagonists & inhibitors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D052243:Resistin / Q000097:blood; D012727:Sex Characteristics; D013662:Tea / Q000009:adverse effects* / Q000737:chemistry; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D003069:Coffee; D016207:Cytokines; D020738:Leptin; D017395:Plasminogen Activator Inhibitor 1; C499624:RETN protein, human; D052243:Resistin; C051321:SERPINE1 protein, human; D013662:Tea; D002110:Caffeine; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
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