title: Adenocarcinoma of the rete testis - a rare case of testicular malignancy.
abstract: BACKGROUND
  Adenocarcinoma of rete testis is an extremely rare dia-gnosis described in around 70 patients worldwide. The prognosis of the disease in metastatic stage is very poor and there is no standard systemic treatment available.
  
  
  METHODS
  Herein we present a unique case report of a 47-year- old man with metastatic adenocarcinoma of rete testis who achieved substantial disease response after four cycles of paclitaxel, ifosfamide and cisplatin. The chemotherapy was administered in five -day regimen, which comprised 250 mg/ m2 of paclitaxel on day one, 20 mg/ m2 of cisplatin on day one to five and 1,2 g/ m2 of ifosfamide on day one to five, in a three-week interval. The patient received prophylactic pegfilgrastim after each cycle of TIP. The treatment was well tolerated -  without any significant toxicity.
  
  
  RESULTS
  Patient achieved a partial 14- month remission.
  
  
  CONCLUSIONS
  On basis of this experience we suggest that paclitaxel, ifosfamide and cisplatin might be adopted as novel agents in treatment of rete testis adenocarcinoma.
authors.forename: M
authors.initials: M
authors.lastname: Chovanec
authors.forename: M
authors.initials: M
authors.lastname: Mego
authors.forename: Z
authors.initials: Z
authors.lastname: Sycova-Mila
authors.forename: J
authors.initials: J
authors.lastname: Obertova
authors.forename: J
authors.initials: J
authors.lastname: Rajec
authors.forename: P
authors.initials: P
authors.lastname: Palacka
authors.forename: J
authors.initials: J
authors.lastname: Mardiak
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D011092:Polyethylene Glycols; D011994:Recombinant Proteins / Q000008:administration & dosage; D012152:Rete Testis; D013736:Testicular Neoplasms / Q000188:drug therapy*
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; C455861:pegfilgrastim; D011092:Polyethylene Glycols; D017239:Paclitaxel; D000069585:Filgrastim; D002945:Cisplatin; D007069:Ifosfamide