title: Inhalation of coriander volatile oil increased anxiolytic-antidepressant-like behaviors and decreased oxidative status in beta-amyloid (1-42) rat model of Alzheimer's disease.
abstract: The present study analyzed the possible anxiolytic, antidepressant and antioxidant proprieties of inhaled coriander volatile oil extracted from Coriandrum sativum var. microcarpum in beta-amyloid (1-42) rat model of Alzheimer's disease. The anxiolytic- and antidepressant-like effects of inhaled coriander volatile oil were studied by means of in vivo (elevated plus-maze and forced swimming tests) approaches. Also, the antioxidant activity in the hippocampus was assessed using catalase specific activity and the total content of the reduced glutathione. The beta-amyloid (1-42)-treated rats exhibited the following: decrease of the locomotor activity, the percentage of the time spent and the number of entries in the open arm within elevated plus-maze test and decrease of swimming and immobility times within forced swimming test. Exposure to coriander volatile oil significantly improved these parameters, suggesting anxiolytic- and antidepressant-like effects. Moreover, coriander volatile oil decreased catalase activity and increased glutathione level in the hippocampus. Our results suggest that multiple exposures to coriander volatile oil can be useful as a mean to counteract anxiety, depression and oxidative stress in Alzheimer's disease conditions.
authors.affiliation: Faculty of Pharmacy, University of Medicine and Pharmacy "Gr. T. Popa", 16 University Str., Iasi 700117, Romania.
authors.forename: Oana
authors.initials: O
authors.lastname: Cioanca
authors.affiliation: Department of Biology, Alexandru Ioan Cuza University, Bd. Carol I, No.11, Iasi 700506, Romania. Electronic address: hritcu@uaic.ro.
authors.forename: Lucian
authors.initials: L
authors.lastname: Hritcu
authors.affiliation: Department of Biology, Alexandru Ioan Cuza University, Bd. Carol I, No.11, Iasi 700506, Romania.
authors.forename: Marius
authors.initials: M
authors.lastname: Mihasan
authors.affiliation: Faculty of Pharmacy, University of Medicine and Pharmacy "Gr. T. Popa", 16 University Str., Iasi 700117, Romania.
authors.forename: Adriana
authors.initials: A
authors.lastname: Trifan
authors.affiliation: Faculty of Pharmacy, University of Medicine and Pharmacy "Gr. T. Popa", 16 University Str., Iasi 700117, Romania.
authors.forename: Monica
authors.initials: M
authors.lastname: Hancianu
mesh_terms: D000280:Administration, Inhalation; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000503:physiopathology; D016229:Amyloid beta-Peptides; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D028526:Coriandrum; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005978:Glutathione / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009483:Neuropsychological Tests; D009822:Oils, Volatile / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D010446:Peptide Fragments; D008517:Phytotherapy; D058225:Plaque, Amyloid / Q000188:drug therapy / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D017208:Rats, Wistar
chemical_list: D016229:Amyloid beta-Peptides; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D009822:Oils, Volatile; D010446:Peptide Fragments; D011619:Psychotropic Drugs; C075222:amyloid beta-protein (1-42); D005978:Glutathione
keywords: Anxiety; Beta-amyloid (1–42); Coriander volatile oil; Depression; Oxidative stress