title: Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus.
abstract: Neural stem cells (NSCs) were recently revealed to exist in the hypothalamus of adult mice. Here, following our observation showing that a partial loss of hypothalamic NSCs caused weight gain and glucose intolerance, we studied if NSCs-based cell therapy could be developed to control these disorders. While hypothalamus-implanted NSCs failed to survive in mice with obesity, NF-κB inhibition induced survival and neurogenesis of these cells, leading to effects in counteracting obesity and glucose intolerance. To generate an alternative cell source, we revealed that iPS-derived NSCs were converted into htNSCs by neuropeptide treatment. Of note, obesity condition potentiated the transfer of carotid artery-injected NSCs into the hypothalamus. These iPS-derived cells when engineered with NF-κB inhibition were also effective in reducing obesity and glucose intolerance, and neurogenesis towards POMCergic and GABAergic lineages was accountable. In conclusion, building NSCs in the hypothalamus represents a strategy for controlling obesity and glucose disorders.
authors.affiliation: Department of Molecular Pharmacology, Albert Einstein College of Medicine, USA ; Diabetes Research Center, Albert Einstein College of Medicine, USA ; Institute of Aging, Albert Einstein College of Medicine, USA.
authors.forename: Juxue
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Molecular Pharmacology, Albert Einstein College of Medicine, USA ; Diabetes Research Center, Albert Einstein College of Medicine, USA ; Institute of Aging, Albert Einstein College of Medicine, USA.
authors.forename: Yizhe
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Molecular Pharmacology, Albert Einstein College of Medicine, USA ; Diabetes Research Center, Albert Einstein College of Medicine, USA ; Institute of Aging, Albert Einstein College of Medicine, USA.
authors.forename: Sudarshana
authors.initials: S
authors.lastname: Purkayastha
authors.affiliation: Department of Molecular Pharmacology, Albert Einstein College of Medicine, USA ; Diabetes Research Center, Albert Einstein College of Medicine, USA ; Institute of Aging, Albert Einstein College of Medicine, USA.
authors.forename: Jingqi
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Molecular Pharmacology, Albert Einstein College of Medicine, USA ; Diabetes Research Center, Albert Einstein College of Medicine, USA ; Institute of Aging, Albert Einstein College of Medicine, USA.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Cai
keywords: Glucose tolerance; Hypothalamus; NF-κB; Neural stem cells; Neuropeptide; Obesity; iPS
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