title: Bitter taste receptor (TAS2R) agonists inhibit IgE-dependent mast cell activation.
authors.affiliation: Institute for Environmental Medicine, Experimental Asthma and Allergy Research, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Ekoff
authors.affiliation: Institute for Environmental Medicine, Experimental Asthma and Allergy Research, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Department of Medicine at Karolinska University Hospital Solna, Clinical Immunology and Allergy Research, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Jeong-Hee
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Institute for Environmental Medicine, Experimental Asthma and Allergy Research, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: James
authors.affiliation: Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Department of Medicine at Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Barbro
authors.initials: B
authors.lastname: Dahlén
authors.affiliation: Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Department of Medicine at Karolinska University Hospital Solna, Clinical Immunology and Allergy Research, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Nilsson
authors.affiliation: Institute for Environmental Medicine, Experimental Asthma and Allergy Research, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden. Electronic address: Sven-Erik.Dahlen@ki.se.
authors.forename: Sven-Erik
authors.initials: SE
authors.lastname: Dahlén
mesh_terms: D002738:Chloroquine / Q000494:pharmacology*; D003915:Dextromethorphan / Q000494:pharmacology*; D005312:Fetal Blood / Q000166:cytology / Q000276:immunology; D005786:Gene Expression Regulation / Q000187:drug effects; D006632:Histamine / Q000096:biosynthesis; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D009665:Noscapine / Q000494:pharmacology*; D015230:Prostaglandin D2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D020033:Protein Isoforms / Q000819:agonists / Q000235:genetics / Q000276:immunology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D043562:Receptors, G-Protein-Coupled / Q000819:agonists* / Q000235:genetics / Q000276:immunology; D017455:Receptors, IgE / Q000235:genetics / Q000276:immunology
chemical_list: D020033:Protein Isoforms; D000644:Quaternary Ammonium Compounds; D043562:Receptors, G-Protein-Coupled; D017455:Receptors, IgE; C568609:TAS2R1 protein, human; D007073:Immunoglobulin E; C043414:denatonium; D003915:Dextromethorphan; D006632:Histamine; D002738:Chloroquine; D009665:Noscapine; D015230:Prostaglandin D2