title: Clinical significance of Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer.
abstract: The purpose of the study was to determine the expression patterns of Wnt-11 and squamous cell carcinoma antigen in cervical cancer tissues and to explore their clinical significance and correlation with clinicopathological parameters. The expression of Wnt-11 and squamous cell carcinoma antigen was detected in 127 cervical cancer tissues, 21 cervical intraepithelial neoplasia, as well as in 20 healthy controls by immunohistochemistry, and the relationship of Wnt-11 and squamous cell carcinoma antigen expression with clinicopathological parameters was analyzed. Both Wnt-11 and squamous cell carcinoma antigen were more commonly expressed in cervical cancer than in cervical intraepithelial neoplasia and in normal cervical tissue (respectively; P < 0.05); further, Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer were positively correlated (r = 0.271, P < 0.05). In comparing the expression with clinicopathological parameters of tumor samples, Wnt-11 and squamous cell carcinoma antigen were both associated with FIGO stage, lymph node metastasis, and tumor size (P < 0.05), but not with patient age, pathological type, or differentiation. Increased Wnt-11 protein levels in cervical carcinoma samples were associated with a poor outcome in univariate and multivariate analysis. Wnt-11 and squamous cell carcinoma antigen are related to the malignancy degree and metastasis of cervical cancer, and thus may play a coordinating role in the occurrence and progression of cervical cancer. The study indicated that Wnt-11 may be a useful prognostic indicator for cervical carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, No. 36 Sanhao St, Heping District, Shenyang, 110004, Liaoning Province, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Wei
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shizhuo
authors.initials: S
authors.lastname: Wang
authors.forename: Xiaoao
authors.initials: X
authors.lastname: Pang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Qingshuang
authors.initials: Q
authors.lastname: Luo
authors.forename: Youbo
authors.initials: Y
authors.lastname: Su
authors.forename: Shulan
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D016022:Case-Control Studies; D002584:Cervix Uteri / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D015843:Serpins / Q000378:metabolism*; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D051153:Wnt Proteins / Q000378:metabolism*; D002578:Uterine Cervical Dysplasia / Q000378:metabolism* / Q000401:mortality / Q000556:secondary
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015843:Serpins; D051153:Wnt Proteins; C540523:Wnt11 protein, human; C051072:squamous cell carcinoma-related antigen
references.citation: J Clin Oncol. 2001 Oct 1;19(19):3960-6
references.pmid: 11579117
references.citation: Mol Cancer. 2010 Mar 10;9:55
references.pmid: 20219091
references.citation: Asian Pac J Cancer Prev. 2010;11(6):1745-7
references.pmid: 21338226
references.citation: J Clin Oncol. 2005 Mar 1;23(7):1455-62
references.pmid: 15735121
references.citation: Cancer Res. 2004 Nov 1;64(21):7918-26
references.pmid: 15520198
references.citation: Eur J Gynaecol Oncol. 2002;23(1):17-20
references.pmid: 11876385
references.citation: Annu Rev Cell Dev Biol. 2004;20:781-810
references.pmid: 15473860
references.citation: Nat Rev Cancer. 2002 May;2(5):342-50
references.pmid: 12044010
references.citation: Eur J Obstet Gynecol Reprod Biol. 2011 Dec;159(2):394-8
references.pmid: 21831511
references.citation: Invest New Drugs. 2010 Jun;28(3):216-24
references.pmid: 19271153
references.citation: Int J Radiat Oncol Biol Phys. 2002 Jan 1;52(1):23-32
references.pmid: 11777619
references.citation: Tumour Biol. 2003 May-Jun;24(3):156-64
references.pmid: 14610320
references.citation: Oncogene. 2011 Apr 28;30(17):2044-56
references.pmid: 21242973
references.citation: Nat Rev Cancer. 2008 May;8(5):387-98
references.pmid: 18432252
references.citation: Int Arch Med. 2008 Jul 07;1(1):10
references.pmid: 18606007
references.citation: J Biol Chem. 2004 Jun 18;279(25):26707-15
references.pmid: 15084607
references.citation: Cancer Res. 2005 Jul 15;65(14):6199-206
references.pmid: 16024621
references.citation: Clin Cancer Res. 2008 Sep 1;14(17):5571-8
references.pmid: 18765550
references.citation: Cancer Res. 2007 May 15;67(10):5017-24
references.pmid: 17510434