title: New acylphloroglucinol derivatives with diverse architectures from Hypericum henryi.
abstract: Hyphenrones A-F (1-6), six polycyclic polyprenylated acylphloroglucinol derivatives with four architectures including three unprecedented cores as exemplified by 1, 3, and 4, were isolated from Hypericum henryi. Compounds 3 and 4 possess two unique 5/8/5 and 6/6/5/8/5 fused ring systems, respectively. Their absolute configurations were defined by experimental and calculated ECD of 4 and X-ray diffractions of 5 and 6, coupled with their putative biosynthetic origins. Three compounds exhibited interesting AChE inhibitory activities.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan P. R. China.
authors.forename: Xing-Wei
authors.initials: XW
authors.lastname: Yang
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Ding
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Yang
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Daneel
authors.initials: D
authors.lastname: Ferreira
authors.forename: Larry A
authors.initials: LA
authors.lastname: Walker
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D045744:Cell Line, Tumor; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002800:Cholinesterase Inhibitors; D011083:Polycyclic Compounds; D010696:Phloroglucinol