title: [Polycyclic aromatic hydrocarbons monohydroxy metabolites level in urine of general population in eight provinces of China].
abstract: OBJECTIVE
  To assess the levels of polycyclic aromatic hydrocarbons monohydroxy metabolites in urine of general population in China among 8 provinces, provide the baseline of the metabolites in the general population.
  
  
  METHODS
  From 2009 to 2010, 18 120 subjects of general population aged 6-60 years old were recruited from 24 areas among 8 provinces in east, west and central areas of China mainland by cluster random sampling. The information of the living environment and health condition were collected by questionnaire and spot urine samples were collected, 4 680 urine samples were analysed by high performance liquid chromatography with tandem mass spectrometry, and monohydroxy metabolites distribution in urine among groups of gender and ages were analysed.
  
  
  RESULTS
  Geometric means (GM) of 2-naphthol, 1-naphthol, 3-phenanthrol and 1-hydroxypyrene concentration in urine (95%CI) were 1.85 (1.75-1.95), 1.55 (1.50-1.61), 0.57 (0.54-0.59) and 0.82 (0.78-0.85) µg/L, respectively;and median are 2.44, <0.50, 0.72 and 0.90 µg/L, respectively. The concentration between male and female were significantly different (P < 0.01), and the concentration among the groups of population were significantly different (P < 0.01), the GM of 2-naphthol among the groups of population aged 6-12, 13-16, 17-20, 21-30, 31-45 and 46-60 years old were 1.60, 1.56, 1.69, 2.23, 1.91 and 1.86 µg/L (χ(2) = 17.90, P < 0.01), the GM of 1-naphthol in the groups were 1.30, 1.16, 1.53, 1.68, 1.80 and 1.52 µg/L (χ(2) = 76.22, P < 0.01), the GM of 3-phenanthrol in the groups were 0.78, 0.76, 0.55, 0.42, 0.50 and 0.99 µg/L (χ(2) = 66.48, P < 0.01), the GM of 1-hydroxypyrene in the groups were 0.77,0.64, 1.00, 0.84, 0.84 and 0.57 µg/L (χ(2) = 51.48, P < 0.01), respectively.
  
  
  CONCLUSIONS
  The distribution of monohydroxy metabolites levels in urine of general population were different, it provided a basic data for the further study of polycyclic aromatic hydrocarbons biomonitoring in the population.
authors.affiliation: Key Laboratory of Chemical Safety and Health,National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Chuanfeng
authors.initials: C
authors.lastname: Huang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Chunguang
authors.initials: C
authors.lastname: Ding
authors.forename: Cuilan
authors.initials: C
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Xinkui
authors.initials: X
authors.lastname: Song
authors.forename: Hanlin
authors.initials: H
authors.lastname: Huang
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhu
authors.forename: Hua
authors.initials: H
authors.lastname: Shao
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Zhao
authors.forename: Changcheng
authors.initials: C
authors.lastname: Han
authors.forename: Shanzhuo
authors.initials: S
authors.lastname: Peng
authors.forename: Xianlong
authors.initials: X
authors.lastname: Jiang
authors.forename: Shanfa
authors.initials: S
authors.lastname: Yu
authors.forename: Hongrong
authors.initials: H
authors.lastname: Ji
authors.forename: Xiaoxi
authors.initials: X
authors.lastname: Zhang
authors.forename: Ran
authors.initials: R
authors.lastname: Sun
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Email: yan_huifang@yeah.net.
authors.forename: Huifang
authors.initials: H
authors.lastname: Yan
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009284:Naphthols / Q000652:urine; D011084:Polycyclic Aromatic Hydrocarbons / Q000652:urine*; D011721:Pyrenes / Q000652:urine; D018571:Sentinel Surveillance; D055815:Young Adult
chemical_list: D009284:Naphthols; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; C029350:1-naphthol; C033146:1-hydroxypyrene; C028405:2-naphthol