title: Nonlinear optical microscopy signal processing strategies in cancer.
abstract: This work reviews the most relevant present-day processing methods used to improve the accuracy of multimodal nonlinear images in the detection of epithelial cancer and the supporting stroma. Special emphasis has been placed on methods of non linear optical (NLO) microscopy image processing such as: second harmonic to autofluorescence ageing index of dermis (SAAID), tumor-associated collagen signatures (TACS), fast Fourier transform (FFT) analysis, and gray level co-occurrence matrix (GLCM)-based methods. These strategies are presented as a set of potential valuable diagnostic tools for early cancer detection. It may be proposed that the combination of NLO microscopy and informatics based image analysis approaches described in this review (all carried out on free software) may represent a powerful tool to investigate collagen organization and remodeling of extracellular matrix in carcinogenesis processes.
authors.affiliation: Microscopy Laboratory Applied to Molecular and Cellular Studies, Bioengineering School, National University of Entre Rios, Oro Verde, Entre Rios, Argentina. ; INFABiC-National Institute of Science and Technology on Photonics Applied to Cell Biology, Campinas, São Paulo, Brazil.
authors.forename: Javier
authors.initials: J
authors.lastname: Adur
authors.affiliation: INFABiC-National Institute of Science and Technology on Photonics Applied to Cell Biology, Campinas, São Paulo, Brazil.
authors.forename: Hernandes F
authors.initials: HF
authors.lastname: Carvalho
authors.affiliation: INFABiC-National Institute of Science and Technology on Photonics Applied to Cell Biology, Campinas, São Paulo, Brazil.
authors.forename: Carlos L
authors.initials: CL
authors.lastname: Cesar
authors.affiliation: Microscopy Laboratory Applied to Molecular and Cellular Studies, Bioengineering School, National University of Entre Rios, Oro Verde, Entre Rios, Argentina.
authors.forename: Víctor H
authors.initials: VH
authors.lastname: Casco
keywords: anisotropy; gray level co-occurrence matrix; nonlinear microscopy; nonlinear signal; tumor-associated collagen signatures
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