title: Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer's disease in Chinese Han population.
abstract: OBJECTIVE
  We conducted a case-control study to investigate whether TREM2 polymorphism (rs75932628-T) was associated with late onset Alzheimer's disease in Chinese Southern Han population.
  
  
  METHODS
  PCR-restriction fragment length polymorphism assay was performed to genotype rs75932628 in 279 cases with late onset Alzheimer's diseases patients and 346 control subjects in Shanghai and Nanjing.
  
  
  RESULTS
  There was no rs75932628-T variant detected in our sample. However, APOEϵ4 was shown closely associated with the risk of Alzheimer's disease (Chi-square = 60·288, P = 0·000).
  
  
  CONCLUSIONS
  Our study suggested that TREM2 (rs75932628-T) was rare in Chinese Han population. Further association studies with large samples are needed to further study the association of TREM2 with late-onset Alzheimer's disease.
authors.forename: Jianfang
authors.initials: J
authors.lastname: Ma
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yulei
authors.initials: Y
authors.lastname: Deng
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Rujin
authors.initials: R
authors.lastname: Ren
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.forename: Huidong
authors.initials: H
authors.lastname: Tang
authors.forename: Shengdi
authors.initials: S
authors.lastname: Chen
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011971:Receptors, Immunologic / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C498715:TREM2 protein, human
keywords: Alzheimer’s disease; Polymorphism,; TREM2,; rs75932628,