title: Lipoprotein-associated phospholipase A2 is associated with postpartum hypertension in women with history of preeclampsia.
abstract: Both hypertension and preeclampsia (PE) are considered as inflammatory diseases. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory marker associated with lipid metabolism. We aimed to study the correlation and predictive value of Lp-PLA2 in postpartum hypertension after PE. A group of 160 PE patients (PE group) and a separate group of 160 normal pregnant women (control group) were recruited from January 2010 to October 2011. The average age in the PE group was 28.4 ± 4.5 years and the average gestational age was 34.7 ± 1.1 weeks. The average age in the control group was 27.8 ± 4.5 years and the average gestational age was 35.5 ± 1.2 weeks. General information (including age, gestational age, parity, history of metabolic disease, family history of high blood pressure, height, body weight before childbirth, and blood pressure) and blood samples were collected for measuring Lp-PLA2 and lipid parameters. From February to April in 2013, 153 cases in the PE group and 132 in the control group were re-called. We assessed their postpartum health, pregnancy, height, weight, and blood pressure. Serum mass of Lp-PLA2 in the PE group (210.67 ± 17.98 ng/mL) was significantly higher compared with that in the control group (174.72 ± 30.26 ng/mL) (P < 0.01). The pro-gestation BMI, systolic blood pressure (SBP), diastolic blood pressure, total cholesterol, triglyceride, and low-density lipoprotein-cholesterol (LDL-C) were also significantly higher. Correlation analysis showed that the level of Lp-PLA2 and SBP (r = 0.31), LDL-C (r = 0.37) were positively correlated. The incidence of postpartum hypertension in the PE group was higher than that in the normal control group. Logistic regression analysis showed that prenatal Lp-PLA2 mass was an independent risk factor for PE postpartum hypertension (OR 1.134,95 % CI 1.086-1.185). ROC curve analysis showed that the sensitivity of predicting postpartum hypertension was 73.2% and the specific degree was 86.6%, with Lp-PLA2 level of 217.75 ng/mL for boundary value. The onset of postpartum hypertension in PE patients may contribute to vascular inflammation, which is associated with antepartum lipid metabolism.
authors.affiliation: Guangdong Women and Children Hospital, 13 Guang Yuan Xi Road, Guangzhou, Guangdong province, 510010, People's Republic of China.
authors.forename: Yuheng
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jianmin
authors.initials: J
authors.lastname: Niu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Duan
authors.forename: Qiong
authors.initials: Q
authors.lastname: Lei
authors.forename: Jiying
authors.initials: J
authors.lastname: Wen
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Lin
authors.forename: Lijuan
authors.initials: L
authors.lastname: Lv
authors.forename: Longding
authors.initials: L
authors.lastname: Chen
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D016022:Case-Control Studies; D050171:Dyslipidemias / Q000150:complications*; D005260:Female; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000097:blood*; D016015:Logistic Models; D049590:Postpartum Period / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012372:ROC Curve; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase
references.citation: J Nutr. 2008 Jul;138(7):1377-82
references.pmid: 18567764
references.citation: Arch Intern Med. 2005 Nov 14;165(20):2420-7
references.pmid: 16287773
references.citation: Hypertension. 2006 Feb;47(2):162-7
references.pmid: 16380527
references.citation: Arterioscler Thromb Vasc Biol. 2002 Dec 1;22(12):2054-8
references.pmid: 12482834
references.citation: N Engl J Med. 1999 Jan 14;340(2):115-26
references.pmid: 9887164
references.citation: Arterioscler Thromb Vasc Biol. 1996 Apr;16(4):591-9
references.pmid: 8624782
references.citation: J Lipid Res. 2009 Sep;50(9):1735-43
references.pmid: 19359705
references.citation: Am J Epidemiol. 1982 Jun;115(6):861-7
references.pmid: 7091144
references.citation: Heart Vessels. 2013 May;28(3):323-9
references.pmid: 22526382
references.citation: Heart Vessels. 2013 Nov;28(6):696-703
references.pmid: 23224329
references.citation: Curr Atheroscler Rep. 2008 Jun;10(3):230-5
references.pmid: 18489851
references.citation: Obstet Gynecol. 2012 Aug;120(2 Pt 1):311-7
references.pmid: 22825090
references.citation: Int J Gynaecol Obstet. 2002 Apr;77(1):67-75
references.pmid: 12094777
references.citation: Int Heart J. 2009 May;50(3):341-51
references.pmid: 19506338
references.citation: Eur Heart J. 2008 Oct;29(20):2561-8
references.pmid: 18308688
references.citation: BMJ. 2011 Aug 25;343:d4891
references.pmid: 21868454
references.citation: Nat Clin Pract Nephrol. 2006 Oct;2(10):582-93
references.pmid: 17003837
references.citation: Hypertension. 2006 Jan;47(1):45-50
references.pmid: 16344375
references.citation: JAMA. 2003 Dec 10;290(22):2945-51
references.pmid: 14665655
references.citation: Am J Obstet Gynecol. 1998 Nov;179(5):1359-75
references.pmid: 9822529
references.citation: Arterioscler Thromb Vasc Biol. 2005 May;25(5):923-31
references.pmid: 15731492
references.citation: Heart Vessels. 2013 Jan;28(1):39-45
references.pmid: 22427252
references.citation: Circulation. 2007 May 29;115(21):2715-21
references.pmid: 17502572
references.citation: Heart Vessels. 2014 Jan;29(1):78-82
references.pmid: 23475325
references.citation: Circulation. 2011 Mar 22;123(11):1243-62
references.pmid: 21325087
references.citation: Eur Heart J. 2005 Jan;26(2):137-44
references.pmid: 15618069
references.citation: Hypertension. 2004 Dec;44(6):859-65
references.pmid: 15492131
references.citation: J Chin Med Assoc. 2007 Oct;70(10):435-8
references.pmid: 17962143
references.citation: BJOG. 2001 Oct;108(10):1081-7
references.pmid: 11702841
references.citation: Ther Adv Cardiovasc Dis. 2008 Aug;2(4):249-59
references.pmid: 19124425
references.citation: Annu Rev Med. 2000;51:149-67
references.pmid: 10774458
references.citation: BMJ Open. 2011 May 24;1(1):e000101
references.pmid: 22021762
references.citation: BMJ. 2007 Nov 10;335(7627):974
references.pmid: 17975258