title: Triazole-linked analogues of DNA and RNA ((TL)DNA and (TL)RNA): synthesis and functions.
abstract: Click chemistry has provided us with access to DNA and RNA analogues with non-natural triazole internucleoside linkages. The bond periodicity of the oligonucleotides was designed to enforce duplex formation with natural congeners, and the non-cleavable linkages protect the oligomers against nuclease digestion. This account reviews the progress of the triazole-linked analogues over the past five years. Reinforced by their synthetic robustness, these analogues may find various utilities as tools for exploratory research.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Isobe
authors.forename: Tomoko
authors.initials: T
authors.lastname: Fujino
mesh_terms: D057930:Click Chemistry; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D012313:RNA / Q000138:chemical synthesis / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques; D014230:Triazoles / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D014230:Triazoles; D012313:RNA; D004247:DNA