title: [A case of malignant peritoneal mesothelioma with the epithelioid histological type, successfully treated with pemetrexed plus cisplatin].
abstract: A 45-year-old man presented with severe abdominal distention with massive ascites due to a diffusely disseminated peritoneal tumor. A core needle biopsy specimen was obtained from the peritoneal lesion. Histological diagnosis was epithelioid type mesothelioma. He did not choose to receive chemotherapy. For 2.5 years, he went without medical intervention, and his disease gradually progressed, leading to a worsening of his symptoms. The patient then chose to be treated with combination chemotherapy of cisplatin and pemetrexed, followed by pemetrexed alone. There was remarkable tumor shrinkage and his symptoms improved. These effects have been sustained for two years after the initial chemotherapy. Chemotherapy appears to have contributed to survival prolongation for this patient. This case exemplifies the fact that malignant peritoneal mesothelioma may progress slowly when fits with some good prognostic factors, and it is important to consider the prognostic factors.
authors.affiliation: Division of Gastroenterology,University of Tsukuba Hospital.
authors.forename: Mariko
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Moriwaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ochi
authors.forename: Rie
authors.initials: R
authors.lastname: Saito
authors.forename: Katsumasa
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Akinori
authors.initials: A
authors.lastname: Sugaya
authors.forename: Daisuke
authors.initials: D
authors.lastname: Akutsu
authors.forename: Yukako
authors.initials: Y
authors.lastname: Hamano
authors.forename: Mamiko
authors.initials: M
authors.lastname: Imanishi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Nakano
authors.forename: Masato
authors.initials: M
authors.lastname: Sugano
authors.forename: Ken
authors.initials: K
authors.lastname: Hara
authors.forename: Ichinosuke
authors.initials: I
authors.lastname: Hyodo
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001201:Ascites / Q000209:etiology; D002945:Cisplatin / Q000008:administration & dosage; D005971:Glutamates / Q000008:administration & dosage; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008654:Mesothelioma / Q000150:complications / Q000188:drug therapy*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D000068437:Pemetrexed; D010534:Peritoneal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine; D002945:Cisplatin