title: Preventive effects of coenzyme Q10 (CoQ10) on steroid-induced osteonecrosis in rats.
abstract: OBJECTIVE
  The aim of this study was to examine the role of coenzyme Q10 (CoQ10) in the prevention of steroid-induced osteonecrosis of the femoral head (ONFH) in rats.
  
  
  METHODS
  The study included 20 Sprague-Dawley rats injected once with 20 mg/kg of methylprednisolone acetate into the right gluteus medius muscle to induce osteonecrosis. Animals were divided into two equal groups; Group 1 received no prophylaxis (control group) and the Group 2 received CoQ10. Hematological examinations were performed before steroid injection (0 weeks) and at 4 weeks after steroid injection. Femoral heads were examined histologically to evaluate osteonecrosis.
  
  
  RESULTS
  Changes in blood glutathione (GSH) and malondialdehyde (MDA) concentrations were less significant in the CoQ10 group. The incidence of histologic changes consistent with early osteonecrosis was lower in the CoQ10 group (2 of 10; 20%) than the control group (7 of 10; 70%).
  
  
  CONCLUSIONS
  Coenzyme Q10 may be useful as a preventing agent in steroid-induced ONFH. Inhibited oxidative stress is a possible mechanism for this effect.
authors.affiliation: Department of Orthopedics and Traumatology, Çanakkale 18 Mart University, Faculty of Medicine, Çanakkale, Turkey. erkakom@yahoo.com.
authors.forename: Erkam
authors.initials: E
authors.lastname: Kömürcü
authors.affiliation: Department of Pathology, Düzce University, Faculty of Medicine, Düzce, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Oktay
authors.affiliation: Department of Orthopedics and Traumatology, Çanakkale 18 Mart University, Faculty of Medicine, Çanakkale, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Kaymaz
authors.affiliation: Department of Orthopedics and Traumatology, Çanakkale 18 Mart University, Faculty of Medicine, Çanakkale, Turkey.
authors.forename: Umut
authors.initials: U
authors.lastname: Hatay Gölge
authors.affiliation: Department of Orthopedics and Traumatology, Çanakkale 18 Mart University, Faculty of Medicine, Çanakkale, Turkey.
authors.forename: Ferdi
authors.initials: F
authors.lastname: Göksel
authors.affiliation: Department of Orthopedics and Traumatology, Çanakkale 18 Mart University, Faculty of Medicine, Çanakkale, Turkey.
authors.forename: Gürdal
authors.initials: G
authors.lastname: Nusran
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005270:Femur Head / Q000473:pathology; D005938:Glucocorticoids / Q000494:pharmacology; D005978:Glutathione / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D008775:Methylprednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077555:Methylprednisolone Acetate; D010020:Osteonecrosis / Q000097:blood / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology
chemical_list: D005938:Glucocorticoids; D020011:Protective Agents; D014815:Vitamins; D014451:Ubiquinone; D000077555:Methylprednisolone Acetate; D008315:Malondialdehyde; C024989:coenzyme Q10; D005978:Glutathione; D008775:Methylprednisolone