title: [Identification and early diagnosis for traditional Chinese medicine-induced liver injury based on translational toxicology].
abstract: Recently traditional Chinese medicine (TCM)-induced liver injury has been an unresolved critical issue which impacts TCM clinical safety. The premise and key step to reduce or avoid drug-induced liver injury (DILI) is to identify the drug source of liver injury in early stage. Then the timely withdrawal of drug and treatment can be done. However, the current diagnosis of DILI is primarily governed by exclusive method relying on administering history supplied by patients and experience judgment from doctors, which lacks objective and reliable diagnostic indices. It is obvious that diagnosis of TCM-induced liver injury is especially difficult due to the complicated composition of TCM medication, as well the frequent combination of Chinese and Western drugs in clinic. In this paper, we proposed construction of research pattern and method for objective identification of TCM-related DILI based on translational toxicology, which utilizes clinical specimen to find specific biomarkers and characteristic blood-entering constituents, as well the clinical biochemistry and liver biopsy. With integration of diagnosis marker database, bibliographic database, medical record database and clinical specimen database, an integrative diagnosis database for TCM-related DILI can be established, which would make a transformation of clinical identification pattern for TCM-induced liver injury from subjective and exclusive to objective and index-supporting mode. This would be helpful to improve rational uses of TCM and promote sustainable development of TCM industry.
authors.forename: Jia-Bo
authors.initials: JB
authors.lastname: Wang
authors.forename: Xiao-He
authors.initials: XH
authors.lastname: Xiao
authors.forename: Xiao-Xi
authors.initials: XX
authors.lastname: Du
authors.forename: Zheng-Sheng
authors.initials: ZS
authors.lastname: Zou
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Song
authors.forename: Xiao-Xin
authors.initials: XX
authors.lastname: Guo
mesh_terms: D000818:Animals; D054316:Biomarkers, Pharmacological / Q000378:metabolism*; D001706:Biopsy / Q000379:methods; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D042241:Early Diagnosis; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008516:Medicine, Chinese Traditional / Q000009:adverse effects*; D051381:Rats
chemical_list: D054316:Biomarkers, Pharmacological