title: Tumour associated epilepsy and glutamate excitotoxicity in patients with gliomas.
abstract: Tumour associated epilepsy (TAE) is common, debilitating and often not successfully controlled by surgical resection of the tumour and administration of multiple anti-epileptic drugs. It represents a cause of significant lost quality of life in an incurable disease and is therefore an important subject for ongoing research. The pathogenesis of TAE is likely to be multifactorial and involve, on the microscopic level, the interaction of genetic factors, changes in the peritumoural microenvironment, alterations in synaptic neurotransmitter release and re-uptake, and the excitotoxic effects of glutamate. On a macroscopic level, the occurrence of TAE is likely to be influenced by tumour size, location and interaction with environmental factors. The optimal treatment of TAE requires a multi-disciplinary approach with input from neurosurgeons, neurologists, radiologists, pathologists and basic scientists. This article reviews the current literature regarding the incidence, treatment, and aetiology of TAE.
authors.affiliation: Department of Neurosurgery, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia; Department of Surgery (RMH/WH), The University of Melbourne, Parkville, VIC, Australia. Electronic address: simon.liubinas@gmail.com.
authors.forename: Simon V
authors.initials: SV
authors.lastname: Liubinas
authors.affiliation: Department of Medicine (RMH/WH), The University of Melbourne, Parkville, VIC, Australia.
authors.forename: Terence J
authors.initials: TJ
authors.lastname: O'Brien
authors.affiliation: Department of Radiology (RMH/WH), The University of Melbourne, Parkville, VIC, Australia.
authors.forename: Bradford M
authors.initials: BM
authors.lastname: Moffat
authors.affiliation: Department of Neurosurgery, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia; Department of Surgery (RMH/WH), The University of Melbourne, Parkville, VIC, Australia.
authors.forename: Katharine J
authors.initials: KJ
authors.lastname: Drummond
authors.affiliation: Department of Neurosurgery, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia; Department of Surgery (RMH/WH), The University of Melbourne, Parkville, VIC, Australia.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Morokoff
authors.affiliation: Department of Neurosurgery, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia; Department of Surgery (RMH/WH), The University of Melbourne, Parkville, VIC, Australia.
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Kaye
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D004827:Epilepsy / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D005910:Glioma / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D011788:Quality of Life; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D018698:Glutamic Acid
keywords: Epilepsy; Excitotoxicity; Glioma; Glutamate; Seizure