title: Serum triglyceride levels correlated with the rate of change in insulin secretion over two years in prediabetic subjects.
abstract: OBJECTIVE
  Increased triglyceride (TG) and decreased high-density lipoprotein cholesterol (HDL-C) levels are considered risk factors for diabetes among prediabetic subjects. In this study, we retrospectively investigated the relationship between lipid profiles and the rate of change in early-phase insulin secretion in prediabetic subjects.
  
  
  METHODS
  To evaluate insulin secretion, 50 prediabetic subjects underwent a 75-gram oral glucose tolerance test at the beginning of the study (baseline), and they were reexamined after a 2-year interval. The results were expressed as insulinogenic index (IGI) and disposition index (DI).
  
  
  RESULTS
  The lipid profiles and indices of insulin secretion had not significantly changed over 2 years. However, Pearson's correlation analyses indicated that the rate of change in IGI and DI was negatively correlated with log-transformed baseline TG level, but not with baseline HDL-C level. Multiple linear regression analysis confirmed that the rate of change in IGI and DI was negatively correlated with the log-transformed baseline TG level (β = -0.38, p = 0.006, and β = -0.39, p = 0.006, respectively).
  
  
  CONCLUSIONS
  Baseline TG level of prediabetic subjects appeared to be associated with rate of change in IGI and DI over a 2-year period, indicating that TG levels among prediabetic subjects should be carefully monitored.
authors.affiliation: Department of Internal Medicine, Iida Municipal Hospital, Nagano, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Shimodaira
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Niwa
authors.forename: Koji
authors.initials: K
authors.lastname: Nakajima
authors.forename: Mutsuhiro
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Norinao
authors.initials: N
authors.lastname: Hanyu
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakayama
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007564:Japan; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood*; D012189:Retrospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides