title: PLCE1 rs2274223 polymorphism contributes to risk of esophageal cancer: evidence based on a meta-analysis.
abstract: We sought to reassess the association of PLCE1 rs2274223 and susceptibility to esophageal cancer (EC) through a meta-analysis of published case-control studies. Using the PubMed and Embase, we identified nine articles including fourteen case-control studies (15,225 cases and 23,620 controls). ORs and 95 % confidence intervals (CIs) of GG vs. AA, GG + GA vs. AA, GG vs. GA + AA, G vs. A, and AG vs. AA genetic models were estimated for each study. All of the genetic models indicated a statistically significant positive association with EC risk. The association appeared most pronounced for carriers of GG genotype (GG vs. AA: OR, 1.35; 95 % CI, 1.17 to 1.57), and weakest for individuals carrying GA genotype (GA vs. AA: OR, 1.13; 95 % CI, 1.05 to 1.23). Stratification analyses showed similar results in the population of Asians and in esophageal squamous cell carcinoma (ESCC). This meta-analysis provides strong statistical evidence for an elevated risk of EC associated with PLCE1 rs2274223. The association remains significant in Asian population and ESCC. Further investigations are warranted to validate these findings.
authors.affiliation: Tianjin Key Laboratory of Food Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, The East entrance to Jinba Road, Beichen, Tianjin, 300134, China.
authors.forename: Jinhan
authors.initials: J
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Hua-Qing
authors.initials: HQ
authors.lastname: Wang
authors.forename: Naiyao
authors.initials: N
authors.lastname: Chen
mesh_terms: D044466:Asian People / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054801:Phosphoinositide Phospholipase C / Q000235:genetics*; D012307:Risk Factors
chemical_list: D054801:Phosphoinositide Phospholipase C; C423320:phospholipase C epsilon
references.citation: Int J Epidemiol. 1997 Dec;26(6):1159-65
references.pmid: 9447394
references.citation: PLoS One. 2013 Oct 07;8(10):e76425
references.pmid: 24116107
references.citation: Eur J Cancer Prev. 2013 Sep;22(5):417-9
references.pmid: 23222411
references.citation: Hepatogastroenterology. 2008 Nov-Dec;55(88):2039-44
references.pmid: 19260473
references.citation: Gene. 2013 Nov 10;530(2):315-22
references.pmid: 23981775
references.citation: Annu Rev Pharmacol Toxicol. 2006;46:355-79
references.pmid: 16402909
references.citation: Cancer Epidemiol. 2013 Oct;37(5):647-52
references.pmid: 23688607
references.citation: Nat Genet. 2011 Jun 05;43(7):679-84
references.pmid: 21642993
references.citation: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references.pmid: 13655060
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: Ann Intern Med. 2009 Aug 18;151(4):264-9, W64
references.pmid: 19622511
references.citation: Arch Med Res. 2012 Oct;43(7):578-84
references.pmid: 23079034
references.citation: Int J Epidemiol. 1992 Oct;21(5):877-82
references.pmid: 1468848
references.citation: Eur J Cancer Prev. 2012 Nov;21(6):541-4
references.pmid: 22805490
references.citation: Biometrics. 1994 Dec;50(4):1088-101
references.pmid: 7786990
references.citation: Genomics. 2007 Oct;90(4):474-81
references.pmid: 17689918
references.citation: Dis Esophagus. 2014 Nov-Dec;27(8):798-801
references.pmid: 24152165
references.citation: Curr Opin Genet Dev. 2010 Jun;20(3):210-7
references.pmid: 20347291
references.citation: Cancer Res. 2004 Dec 15;64(24):8808-10
references.pmid: 15604236
references.citation: Cancer Genet Cytogenet. 2010 Jul 15;200(2):110-9
references.pmid: 20620593
references.citation: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references.pmid: 21296855
references.citation: Mol Biol Rep. 2012 Sep;39(9):9105-11
references.pmid: 22744421
references.citation: Tumour Biol. 2013 Dec;34(6):3537-44
references.pmid: 23797815
references.citation: J Cell Sci. 2006 Apr 1;119(Pt 7):1307-19
references.pmid: 16537651
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: J Med Virol. 2014 Apr;86(4):608-17
references.pmid: 24127316
references.citation: Nat Genet. 2010 Sep;42(9):764-7
references.pmid: 20729852
references.citation: Nat Genet. 2006 Dec;38(12):1397-405
references.pmid: 17086182
references.citation: Carcinogenesis. 2009 Aug;30(8):1424-32
references.pmid: 19458037
references.citation: J Biol Chem. 2006 May 19;281(20):14026-40
references.pmid: 16565089
references.citation: Ann Surg Oncol. 2012 Jul;19(7):2403-10
references.pmid: 22203178
references.citation: Pol Merkur Lekarski. 2009 Jan;26(151):82-5
references.pmid: 19391515
references.citation: Carcinogenesis. 2012 Nov;33(11):2155-61
references.pmid: 22865593
references.citation: Nat Genet. 2010 Sep;42(9):759-63
references.pmid: 20729853
references.citation: Mol Interv. 2003 Aug;3(5):273-80
references.pmid: 14993441
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120