title: [Significance of serum cholesterol and fibrinogen in evaluating the risk of glomerulosclerosis in children with nephrotic syndrome].
abstract: OBJECTIVE
  To investigate the significance of serum cholesterol and fibrinogen (Fib) in evaluating the risk of glomerulosclerosis in children with nephrotic syndrome.
  
  
  METHODS
  Sixty-three children with primary nephrotic syndrome were divided into two groups according to their pathological types: minimal change glomerulopathy (MCG) (n=39) and focal segmental glomerulosclerosis (FSGS) groups (n=24). Serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C and Fib and 24-hour urinary protein excretion were retrospectively analyzed.
  
  
  RESULTS
  Serum levels of TC, non-HDL-C, and LDL-C were significantly higher in the FSGS group than in the MCG group (P<0.05), but there were no significant differences in HDL-C, Fib and 24-hour urinary protein excretion between the two groups (P>0.05). According to the results of logistic regression analysis, high levels of LDL-C, non-HDL-C and TC were risk factors for FSGS (P<0.05). In patients whose proteinuria did not disappear after taking enough glucocorticoid for 4 weeks, the level of non-HDL-C was significantly higher in the FSGS group than in the MCG group (P<0.05); there were no significant differences in TC, LDL-C, HDL-C, and Fib between the MCG and FSGS groups (P>0.05).
  
  
  CONCLUSIONS
  Serum cholesterol, especially non-LDL-C, is of great significance in evaluating the risk of glomerulosclerosis in children with nephrotic syndrome. There is no sufficient evidence to support serum Fib as a marker for predicting glomerulosclerosis in these children.
authors.affiliation: Department of Pediatrics, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. zhangjianjiang10@163.com.
authors.forename: Jian-Jiang
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Shu-Qin
authors.initials: SQ
authors.lastname: Fu
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Dou
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Shi
authors.forename: Miao
authors.initials: M
authors.lastname: Wang
authors.forename: Xi-Yan
authors.initials: XY
authors.lastname: Tian
mesh_terms: D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D009402:Nephrosis, Lipoid / Q000209:etiology*; D009404:Nephrotic Syndrome / Q000097:blood / Q000150:complications*; D012189:Retrospective Studies; D012306:Risk
chemical_list: D005340:Fibrinogen; D002784:Cholesterol