title: Detection of lung tumors in mice using a 1-tesla compact magnetic resonance imaging system.
abstract: Due to their small size, lung tumors in rodents are typically investigated using high-field magnetic resonance (MR) systems (4.7 T or higher) to achieve higher signal-to-noise ratios, although low-field MR systems are less sensitive to susceptibility artifacts caused by air in the lung. We investigated the feasibility of detecting lung tumors in living, freely breathing mice with a 1-T compact permanent magnet MR system. In total, 4 mice were used, and MR images of mouse lungs were acquired using a T1-weighted three-dimensional fast low-angle shot sequence without cardiac or respiratory gating. The delineation and size of lung tumors were assessed and compared with histopathological findings. Submillimeter lesions were demonstrated as hyperintense, relative to the surrounding lung parenchyma, and were delineated clearly. Among the 13 lesions validated in histopathological sections, 11 were detected in MR images; the MR detection rate was thus 84.6%. A strong correlation was obtained in size measurements between MR images and histological sections. Thus, a dedicated low-field MR system can be used to detect lung tumors in living mice noninvasively without gating.
authors.affiliation: Department of Radiology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan; Department of Radiology, Qi Lu Hospital of Shandong University, Jinan, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Akashi
authors.affiliation: Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Murakami
authors.affiliation: Department of Diagnostic Radiology, Kitasato University School of Medicine, Minami-ku, Sagamihara, Kanagawa, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Inoue
authors.affiliation: Department of Radiology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Furuta
authors.affiliation: Department of Radiology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan.
authors.forename: Haruyasu
authors.initials: H
authors.lastname: Yamada
authors.affiliation: Department of Radiology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Kuni
authors.initials: K
authors.lastname: Ohtomo
authors.affiliation: Department of Radiology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kiryu
mesh_terms: D000818:Animals; D005260:Female; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods*; D051379:Mice; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging*; D011859:Radiography; D012680:Sensitivity and Specificity
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