title: Identification of ethnically specific genetic variations in pan-asian ethnos.
abstract: Asian populations contain a variety of ethnic groups that have ethnically specific genetic differences. Ethnic variants may be highly relevant in disease and human differentiation studies. Here, we identified ethnically specific variants and then investigated their distribution across Asian ethnic groups. We obtained 58,960 Pan-Asian single nucleotide polymorphisms of 1,953 individuals from 72 ethnic groups of 11 Asian countries. We selected 9,306 ethnic variant single nucleotide polymorphisms (ESNPs) and 5,167 ethnic variant copy number polymorphisms (ECNPs) using the nearest shrunken centroid method. We analyzed ESNPs and ECNPs in 3 hierarchical levels: superpopulation, subpopulation, and ethnic population. We also identified ESNP- and ECNP-related genes and their features. This study represents the first attempt to identify Asian ESNP and ECNP markers, which can be used to identify genetic differences and predict disease susceptibility and drug effectiveness in Asian ethnic populations.
authors.affiliation: Korean BioInformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea.
authors.forename: Jin Ok
authors.initials: JO
authors.lastname: Yang
authors.affiliation: Korean BioInformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea.
authors.forename: Sohyun
authors.initials: S
authors.lastname: Hwang
authors.affiliation: Bioinformatics Team, CSP R&D Center, Samsung SDS, Seoul 135-918, Korea.
authors.forename: Woo-Yeon
authors.initials: WY
authors.lastname: Kim
authors.affiliation: Korean BioInformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea.
authors.forename: Seong-Jin
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Samsung Genome Institute, Samsung Medical Center, Seoul 135-710, Korea.
authors.forename: Sang Cheol
authors.initials: SC
authors.lastname: Kim
authors.affiliation: Korean BioInformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea.
authors.forename: Kiejung
authors.initials: K
authors.lastname: Park
authors.affiliation: Korean BioInformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea.
authors.forename: Byungwook
authors.initials: B
authors.lastname: Lee
keywords: DNA copy number variations; classification; ethnic groups; genotype; single nucleotide polymorphism
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