title: Dynamic kinetic resolution of dehydrocoronamic acid.
abstract: Dehydrocoronamic acid can be racemised by dehydration of an N-acyl derivative to an azlactone, which undergoes facile racemisation. For the N-trifluoroacetyl derivative, the racemisation process was combined with an enzymatic resolution, to achieve a dynamic kinetic resolution process by which the racemate can be converted to either enantiomer.
authors.affiliation: Chirotech Technology Centre, Dr Reddy's Laboratories EU Ltd., Unit 410 Cambridge Science Park, Milton Road, Cambridge, CB4 0PE, UK. mfox@drreddys.com.
authors.forename: David A
authors.initials: DA
authors.lastname: Chaplin
authors.forename: Martin E
authors.initials: ME
authors.lastname: Fox
authors.forename: Sebastian H B
authors.initials: SH
authors.lastname: Kroll
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D007700:Kinetics; D066244:Proton Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; C043950:1-amino-2-ethylcyclopropane-1-carboxylic acid