title: [Efficacy of noninvasive ventilation on in-hospital mortality in patients with acute cardiogenic pulmonary edema: a meta-analysis].
abstract: OBJECTIVE
  To evaluate the efficacy of noninvasive ventilation on in-hospital mortality in adult patients with acute cardiogenic pulmonary edema (ACPE) .
  
  
  METHODS
  We searched PubMed, Embase, Wanfang, CNKI data to find relevant randomized controlled trials of noninvasive ventilation for ACPE, which were reported from January 1980 to December 2012. Meta-analysis was performed with software of RevMan 5.1.
  
  
  RESULTS
  According to inclusive criteria and exclusion criteria, 35 randomized controlled trials with 3 204 patients were enrolled for analyses. Meta-analysis of the trials showed that continuous positive airway pressure (CPAP) reduced in-hospital mortality by 43% (RR = 0.57, 95%CI 0.43-0.75, P < 0.01) and bilevel positive pressure ventilation (BiPAP) reduced mortality by 31% (RR = 0.69, 95%CI 0.51-0.94, P = 0.02) compared with standard therapy. There were no significant differences in in-hospital mortality between BiPAP and CPAP (RR = 1.09, 95%CI 0.80-1.49, P = 0.57) and myocardial infarction rate (BiPAP vs. CPAP: RR = 1.20, 95%CI 0.95-1.52, P = 0.12; BiPAP vs. standard therapy: RR = 1.10, 95%CI 0.88-1.38, P = 0.40).
  
  
  CONCLUSIONS
  Noninvasive ventilation (BiPAP and CPAP) could reduce in-hospital mortality of adult patients with ACPE, which could be used as first-line management strategies for these patients.
authors.affiliation: Department of Integrated Intensive Care Unit, First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052, China.
authors.forename: Tongwen
authors.initials: T
authors.lastname: Sun
authors.forename: Youdong
authors.initials: Y
authors.lastname: Wan
authors.forename: Quancheng
authors.initials: Q
authors.lastname: Kan
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.forename: Haimu
authors.initials: H
authors.lastname: Yao
authors.forename: Fangxia
authors.initials: F
authors.lastname: Guan
authors.forename: Jinying
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Email: suntongwen@163.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
mesh_terms: D000208:Acute Disease; D045422:Continuous Positive Airway Pressure; D017052:Hospital Mortality; D006801:Humans; D063087:Noninvasive Ventilation; D011654:Pulmonary Edema / Q000401:mortality* / Q000628:therapy; D016032:Randomized Controlled Trials as Topic