title: Carbohydrate-based first stereoselective total synthesis of bioactive cytospolide P.
abstract: A facile carbohydrate-based highly stereoselective synthetic route has been developed for the cytospolide P (1) from D-ribose for the first time. Key steps of the synthesis include Wittig homologation, regioselective epoxide ring opening, Sharpless asymmetric epoxidation, Evans aldol reaction, and Yamaguchi macrolactonization.
authors.affiliation: Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. chinaraju@iict.res.in.
authors.forename: Pathi
authors.initials: P
authors.lastname: Suman
authors.forename: Bhimapaka China
authors.initials: BC
authors.lastname: Raju
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D007202:Indicators and Reagents; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D002241:Carbohydrates; D007202:Indicators and Reagents; D018942:Macrolides; C000595171:cytospolide P