title: Nutropioids regulate gut-brain circuitry controlling food intake.
abstract: The modulation of hunger sensations by the µ-opioid receptor (MOR) present in the brain is an established fact. That MORs expressed in the periphery could have a similar role was outstanding. Using portal infusions of agonists and/or antagonists of MOR in conscious rodents, we have shown that MORs present in the walls of the portal vein nervous system control a gut-brain circuit of induction of intestinal gluconeogenesis (IGN), a function controlling hunger sensations. Then, we have shown that peptides and proteins promote a MOR-dependent induction of IGN. Peptides have no effect in mice knockout for MOR. MOR-KO mice are also insensitive to satiety induced by protein-enriched diets. In addition, portal infusions of MOR modulators have no effect on food intake in mice deficient for IGN. Thus, the regulation by portal MORs and peptides of a gut-brain neural circuit of induction of IGN is a causal link in the phenomenon of satiety induced by dietary protein.
authors.affiliation: National Institute of Health and Medical Research, U855, and University of Lyon, Lyon, and University Lyon 1, Villeurbanne, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Mithieux
mesh_terms: D000818:Animals; D001066:Appetite / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000378:metabolism*; D006801:Humans; D009434:Neural Pathways / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D012527:Satiation / Q000502:physiology*
chemical_list: D017450:Receptors, Opioid, mu