title: Regulation of miR-23b expression and its dual role on ROS production and tumour development.
abstract: Among the wide family of microRNAs, microRNA 23b (miR-23b) intriguingly assumes opposite roles on regulation of reactive oxygen species (ROS) and on the development of human cancers. In this review we describe novel findings concerning the molecular events involved in miR-23b gene activation or repression and in both ROS regulation and tumour development. In particular, we define the molecular targets of miR-23b that determine its function as either a tumour suppressor or oncomir in different cell types. Finally, we analyze the involvement of miR-23b in cancer cell metabolism, including autophagy, and in biomarker signatures of microRNAs allowing a prognostic and therapeutic evaluation in various human cancers.
authors.affiliation: Department of Life and Reproduction Sciences, Biochemistry Section, University of Verona, Verona, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Donadelli
authors.affiliation: Department of Life and Reproduction Sciences, Biochemistry Section, University of Verona, Verona, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Dando
authors.affiliation: Department of Life and Reproduction Sciences, Biochemistry Section, University of Verona, Verona, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Fiorini
authors.affiliation: Department of Life and Reproduction Sciences, Biochemistry Section, University of Verona, Verona, Italy. Electronic address: marta.palmieri@univr.it.
authors.forename: Marta
authors.initials: M
authors.lastname: Palmieri
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: C552430:MIRN23a microRNA, human; D035683:MicroRNAs; D017382:Reactive Oxygen Species
keywords: Cancer; MicroRNAs; Reactive oxygen species; Transcriptional regulation; miR-23b