title: [Study on the association between catechol-O-methyltransferase gene polymorphisms and type 2 diabetes mellitus].
abstract: OBJECTIVE
  To evaluate the association between the two single nucleotide polymorphisms located in catechol-O-methyltransferase (COMT) gene and type 2 diabetes mellitus (T2DM)in Han population in Guangdong province.
  
  
  METHODS
  Two tagSNPs (rs4646312 and rs4680) were picked out from COMT gene. Using the SNPscan(TM) Kit, SNP genotyping was then performed, in two cohorts, including 595 cases and 725 controls. Finally, Chi-square test, logistic regression model and other methods were employed for statistical analysis.
  
  
  RESULTS
  The frequencies of TT, CT and CC of rs4646312 appeared to be 304(51.1%), 234(39.3%)and 57 (8.6%) in cases, 323 (44.6%), 319 (44.0%) and 83(11.4%)in controls, respectively. The frequencies of GG,GA and AA of rs4680 were 311(52.4%), 236 (39.8%) and 46(7.8%)in cases, 417(57.7%), 265 (36.6%) and 41 (5.7%) in controls, respectively.
  
  
  RESULTS
  showed that SNP rs4646312 was significantly associated with T2DM both in allelic association analysis (P = 0.020,OR = 1.26, 95%CI:1.04-1.53)and in recessive model (P = 0.022, OR = 1.35, 95% CI:1.05-1.74)after adjustment for sex,BMI and TG. The association between rs4680 and T2DM was not significant, but BMI was remarkably different among the three genotypes of rs4680 after controlling for other factors.
  
  
  CONCLUSIONS
  SNP rs4646312 of COMT gene was associated with the increased risk of T2DM in Han population in Guangdong province. However, rs4680 was not significantly associated with T2DM.
authors.affiliation: Department of Biostatistics, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China; Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical College.
authors.forename: Liangchang
authors.initials: L
authors.lastname: Xiu
authors.affiliation: Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical College.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Houjie Hospital.
authors.forename: Shancun
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical College.
authors.forename: Meihua
authors.initials: M
authors.lastname: Lin
authors.affiliation: Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical College.
authors.forename: Ping
authors.initials: P
authors.lastname: Ouyang
authors.affiliation: Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical College.
authors.forename: Jiheng
authors.initials: J
authors.lastname: Qin
authors.affiliation: Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical College.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical College.
authors.forename: Danli
authors.initials: D
authors.lastname: Kong
authors.affiliation: Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical College.
authors.forename: Shaoqi
authors.initials: S
authors.lastname: Rao
authors.affiliation: Department of Biostatistics, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China; Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical College.
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Ding
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D002394:Catechol O-Methyltransferase