title: Cutaneous metastasis of gastric cardia adenocarcinoma in a patient: a case report.
abstract: A large proportion of gastric cardia adenocarcinoma (GCA) present initially in an advanced stage in China. Skin metastasis of primary GCA rarely occurs and the incidence of it is still unclear yet. Here we report one case of skin metastasis from GCA in a 58-year-old male patient who underwent gastric cardia resection in 2002 and did not undergo chemotherapy. However, he was diagnosed with anastomotic stoma adenocarcinoma by gastroscopy and histological biopsy in 2012.4. Then he underwent four cycles of "XELOX" regimen chemotherapy and the evaluation was PR. Upper gastrointestinal bleeding occurred and he was administered hemostatic therapy in 2012.9; meanwhile, he suffered from severe pains all over the body and received slow-release morphine. However, he was found to have dozens of cutaneous metastasizes in the skin of abdominal and back. Then, he underwent best supportive care and died of cachexia in 2013.5. GCA cutaneous metastasis indicates a highly invasive potential of tumors, poor chemo-radiotherapy efficacy and poor prognosis. The patient may survive just for another several months without the treatment of anti-tumor agents. Appropriate treatment may prolong patient survival.
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology No. 24 Jinghua Road, Luoyang, Henan, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology No. 24 Jinghua Road, Luoyang, Henan, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Kong
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology No. 24 Jinghua Road, Luoyang, Henan, China.
authors.forename: Xiaozhi
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology No. 24 Jinghua Road, Luoyang, Henan, China.
authors.forename: Shegan
authors.initials: S
authors.lastname: Gao
keywords: Gastric cardia adenocarcinoma; cutaneous metastasis
references.citation: J Med Case Rep. 2009 Feb 16;3:65
references.pmid: 19220898
references.citation: J Med Case Rep. 2009 Jan 29;3:32
references.pmid: 19178730
references.citation: Arch Esp Urol. 2005 Apr;58(3):247-50
references.pmid: 15906619
references.citation: Nature. 2000 Aug 3;406(6795):536-40
references.pmid: 10952317
references.citation: Ann Dermatol. 2013 Feb;25(1):99-103
references.pmid: 23467457
references.citation: Arch Dermatol. 1972 Jun;105(6):862-8
references.pmid: 5030236
references.citation: J Exp Med. 1999 Dec 6;190(11):1669-78
references.pmid: 10587357
references.citation: Cancer. 1972 May;29(5):1298-307
references.pmid: 4336632
references.citation: N Engl J Med. 1991 Oct 31;325(18):1316
references.pmid: 1833645
references.citation: J Am Acad Dermatol. 1990 Jan;22(1):19-26
references.pmid: 2298962
references.citation: Clin J Oncol Nurs. 2002 Sep-Oct;6(5):255-60
references.pmid: 12240484
references.citation: J Am Acad Dermatol. 1993 Aug;29(2 Pt 1):228-36
references.pmid: 8335743
references.citation: J Cutan Pathol. 2004 Jul;31(6):419-30
references.pmid: 15186430
references.citation: Australas J Dermatol. 2007 Aug;48(3):187-9
references.pmid: 17680973
references.citation: J Med Case Rep. 2011 Sep 28;5:484
references.pmid: 21955819
references.citation: Histopathology. 2014 Feb;64(3):453-5
references.pmid: 24410806
references.citation: Cases J. 2010 Jan 15;3:28
references.pmid: 20157437
references.citation: J Clin Invest. 1995 Oct;96(4):1815-22
references.pmid: 7560073