title: The chemical logic of plant natural product biosynthesis.
abstract: Understanding the logic of plant natural product biosynthesis is important for three reasons: it guides the search for new natural products and pathways, illuminates the function of existing pathways in the context of host biology, and builds an enabling 'parts list' for plant and microbial metabolic engineering. In this review, we highlight the chemical themes that underlie a broad range of plant pathways, dividing pathways into two parts: scaffold-generating steps that draw on a limited set of chemistries, and tailoring reactions that produce a wide range of end products from a small number of common scaffolds.
authors.affiliation: Department of Chemical Engineering, Stanford University, Stanford, CA 94305, United States.
authors.forename: Gülbenk
authors.initials: G
authors.lastname: Anarat-Cappillino
authors.affiliation: Department of Chemical Engineering, Stanford University, Stanford, CA 94305, United States. Electronic address: sattely@stanford.edu.
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Sattely
mesh_terms: D000447:Aldehydes / Q000378:metabolism*; D000588:Amines / Q000378:metabolism; D001688:Biological Products / Q000378:metabolism*; D003500:Cyclization; D010084:Oxidation-Reduction; D010944:Plants / Q000378:metabolism*
chemical_list: D000447:Aldehydes; D000588:Amines; D001688:Biological Products
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13673-8
references.pmid: 19666570
references.citation: Plant Cell Physiol. 2007 Mar;48(3):550-4
references.pmid: 17283012
references.citation: Nat Chem Biol. 2008 Sep;4(9):564-73
references.pmid: 18690217
references.citation: Plant Physiol Biochem. 2009 Mar;47(3):167-74
references.pmid: 19071029
references.citation: Science. 2012 Jun 29;336(6089):1667-70
references.pmid: 22745420
references.citation: Science. 1997 Jan 17;275(5298):362-6
references.pmid: 8994027
references.citation: Arch Biochem Biophys. 2011 Mar 1;507(1):194-203
references.pmid: 20920462
references.citation: Annu Rev Plant Biol. 2008;59:735-69
references.pmid: 18251710
references.citation: Chembiochem. 2012 Sep 3;13(13):1846-59
references.pmid: 22807086
references.citation: Science. 2012 Aug 24;337(6097):960-4
references.pmid: 22923580
references.citation: Mol Plant. 2010 Jan;3(1):2-20
references.pmid: 20035037
references.citation: Nature. 2012 Dec 6;492(7427):138-42
references.pmid: 23172143
references.citation: Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13504-9
references.pmid: 21825160
references.citation: J Biol Chem. 2013 Feb 1;288(5):3163-73
references.pmid: 23243312
references.citation: Phytochem Rev. 2011 Sep;10(3):397-412
references.pmid: 21909286
references.citation: Methods Enzymol. 2012;515:317-35
references.pmid: 22999180
references.citation: Curr Opin Plant Biol. 2010 Jun;13(3):338-47
references.pmid: 20197238
references.citation: Science. 2009 Sep 25;325(5948):1688-92
references.pmid: 19779199
references.citation: J Am Chem Soc. 2008 Jan 16;130(2):710-23
references.pmid: 18081287
references.citation: J Biol Chem. 2001 Jul 6;276(27):24790-6
references.pmid: 11333274
references.citation: J Biol Chem. 2012 Oct 5;287(41):33957-72
references.pmid: 22854967
references.citation: Curr Opin Plant Biol. 2013 Jun;16(3):365-72
references.pmid: 23481348
references.citation: Methods Enzymol. 2012;515:291-313
references.pmid: 22999179
references.citation: Nat Chem Biol. 2009 Mar;5(3):151-3
references.pmid: 19151732
references.citation: Bioorg Med Chem Lett. 1998 Nov 3;8(21):3037-8
references.pmid: 9873671
references.citation: J Biol Chem. 2013 Jan 4;288(1):466-79
references.pmid: 23161544
references.citation: Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13625-8
references.pmid: 24151049
references.citation: J Biotechnol. 2013 Jan 20;163(2):166-78
references.pmid: 22687248
references.citation: Nat Prod Rep. 2013 Jul;30(7):988-1027
references.pmid: 23736284
references.citation: Nat Prod Rep. 2011 Aug;28(8):1381-405
references.pmid: 21681321
references.citation: Plant Biotechnol J. 2013 Feb;11(2):169-96
references.pmid: 23171352
references.citation: Science. 2013 Jul 12;341(6142):175-9
references.pmid: 23788733
references.citation: Plant J. 2011 Apr;66(1):212-29
references.pmid: 21443633
references.citation: Angew Chem Int Ed Engl. 2011 Sep 5;50(37):8538-64
references.pmid: 21830283
references.citation: Phytochemistry. 2013 Jul;91:29-51
references.pmid: 22721782
references.citation: Phytochemistry. 2009 Oct-Nov;70(15-16):1621-37
references.pmid: 19793600
references.citation: J Am Chem Soc. 2012 Jan 25;134(3):1498-500
references.pmid: 22229634
references.citation: Curr Opin Chem Biol. 2012 Apr;16(1-2):179-85
references.pmid: 22245533
references.citation: Phytochemistry. 2001 Jan;56(1):5-51
references.pmid: 11198818
references.citation: Appl Microbiol Biotechnol. 2013 Oct;97(19):8427-38
references.pmid: 23989917
references.citation: Biochemistry. 2007 Sep 4;46(35):10153-61
references.pmid: 17696451
references.citation: Angew Chem Int Ed Engl. 2010;49(1):202-4
references.pmid: 19946920
references.citation: Science. 2010 Dec 3;330(6009):1355-8
references.pmid: 21127247
references.citation: Trends Plant Sci. 2006 Feb;11(2):80-8
references.pmid: 16406305
references.citation: Nat Struct Biol. 1999 Aug;6(8):775-84
references.pmid: 10426957
references.citation: Curr Opin Biotechnol. 2014 Apr;26:91-9
references.pmid: 24679264