title: Spectroscopical study of bacteriopurpurinimide-naphthalimide conjugates for fluorescent diagnostics and photodynamic therapy.
abstract: Two novel bis(chromophoric) dyads ABPI-NI1 and ABPI-NI2 containing 1,8-naphthalimide and bacteriopurpurinimide units linked by p-phenylene-methylene (ABPI-NI1) and pentamethylene (ABPI-NI2) spacers were prepared to test their ability to be used in the design of effective agents for both photodynamic therapy (PDT) and fluorescent tumor imaging. Photophysical studies revealed that the emission from the naphthalimide chromophore in both conjugates was partially quenched due to resonance energy transfer between the photoactive components. Compound ABPI-NI2 with more sterically flexible oligomethylene group demonstrated higher fluorescence intensity as compared with that for ABPI-NI1.
authors.affiliation: A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences (INEOS RAS), Vavilova str. 28, 119991 Moscow, Russia. Electronic address: pavel@ineos.ac.ru.
authors.forename: Pavel A
authors.initials: PA
authors.lastname: Panchenko
authors.affiliation: A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences (INEOS RAS), Vavilova str. 28, 119991 Moscow, Russia.
authors.forename: Antonina N
authors.initials: AN
authors.lastname: Sergeeva
authors.affiliation: A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences (INEOS RAS), Vavilova str. 28, 119991 Moscow, Russia.
authors.forename: Olga A
authors.initials: OA
authors.lastname: Fedorova
authors.affiliation: A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences (INEOS RAS), Vavilova str. 28, 119991 Moscow, Russia.
authors.forename: Yuri V
authors.initials: YV
authors.lastname: Fedorov
authors.affiliation: Lomonosov Moscow State University of Fine Chemical Technologies, Vernadskogo pr. 86, 119571 Moscow, Russia.
authors.forename: Roman I
authors.initials: RI
authors.lastname: Reshetnikov
authors.affiliation: Lomonosov Moscow State University of Fine Chemical Technologies, Vernadskogo pr. 86, 119571 Moscow, Russia.
authors.forename: Anastasiya E
authors.initials: AE
authors.lastname: Schelkunova
authors.affiliation: Lomonosov Moscow State University of Fine Chemical Technologies, Vernadskogo pr. 86, 119571 Moscow, Russia.
authors.forename: Mikhail A
authors.initials: MA
authors.lastname: Grin
authors.affiliation: Lomonosov Moscow State University of Fine Chemical Technologies, Vernadskogo pr. 86, 119571 Moscow, Russia.
authors.forename: Andrey F
authors.initials: AF
authors.lastname: Mironov
authors.affiliation: Laboratoire Ondes et Matière d'Aquitaine (LOMA), UMR CNRS 5798, Bordeaux 1 University, Cours de la Libération 351, 33405 Talence, France.
authors.forename: Gediminas
authors.initials: G
authors.lastname: Jonusauskas
mesh_terms: D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D053644:Naphthalimides / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D010778:Photochemotherapy; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D011789:Quantum Theory
chemical_list: D005456:Fluorescent Dyes; D053644:Naphthalimides; D011166:Porphyrins
keywords: 1,8-Naphthalimide; Bacteriopurpurinimide; Conjugate; Fluorescence imaging; PM6 semiempirical calculations; Photodynamic therapy; Resonance energy transfer