title: High-risk HPV nucleic acid detection kit-the careHPV test -a new detection method for screening.
abstract: This study assessed the clinical accuracy of the correlation between the careHPV test and the HC2 test, as well as the correlation between the careHPV test and the HPV-PCR test. From September 21 to December 31, 2009, 419 cervical specimens from women, 30-49 years, were collected. All women were assessed by Digene HC2 High-Risk HPV DNA Test (HC2), careHPV test, and HPV-PCR. The concordance rate between careHPV and HC2 was 93.81% and between careHPV and HPV-PCR 88.12%. The sensitivity and specificity of the careHPV test to detect cancers of equal or greater severity than CIN 2 were 85.71% and 83.15% respectively. Results from careHPV, HC2, and HPV-PCR were highly consistent. The careHPV test has good sensitivity and specificity for the detection of HPV infection and is a promising primary screening method for cervical cancer in low-resource regions.
authors.affiliation: Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School; Nanjing Medical University; Nanjing University of Chinese Medicine. 321 Zhongshan Road, Nanjing 210008, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ying
authors.affiliation: Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School; Nanjing Medical University; Nanjing University of Chinese Medicine. 321 Zhongshan Road, Nanjing 210008, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Jing
authors.affiliation: Department of Cancer Epidemiology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 South Panjiayuan LaneP.O. Box 2258, Beijing 100021, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Fanghui
authors.affiliation: Department of Cancer Epidemiology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 South Panjiayuan LaneP.O. Box 2258, Beijing 100021, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Youlin
authors.affiliation: Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School; Nanjing Medical University; Nanjing University of Chinese Medicine. 321 Zhongshan Road, Nanjing 210008, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Yali
mesh_terms: D000328:Adult; D019540:Area Under Curve; D002584:Cervix Uteri / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D012372:ROC Curve; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000821:virology
chemical_list: D004279:DNA, Viral; D011933:Reagent Kits, Diagnostic
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