title: Significance of maternal and cord blood nucleated red blood cell count in pregnancies complicated by preeclampsia.
abstract: OBJECTIVE
  To evaluate the effect of preeclampsia on the cord blood and maternal NRBC count and to correlate NRBC count and neonatal outcome in preeclampsia and control groups.
  
  
  METHODS
  This is a prospective case control observational study.
  
  
  METHODS
  Maternal and cord blood NRBC counts were studied in 50 preeclamptic women and 50 healthy pregnant women. Using automated cell counter total leucocyte count was obtained and peripheral smear was prepared to obtain NRBC count. Corrected WBC count and NRBC count/100 leucocytes in maternal venous blood and in cord blood were compared between the 2 groups.
  
  
  RESULTS
  No significant differences were found in corrected WBC count in maternal and cord blood in cases and controls. Significant differences were found in mean cord blood NRBC count in preeclampsia and control groups (40.0 ± 85.1 and 5.9 ± 6.3, P = 0.006). The mean maternal NRBC count in two groups was 2.4 ± 9.0 and 0.8 ± 1.5, respectively (P = 0.214). Cord blood NRBC count cut off value ≤ 13 could rule out adverse neonatal outcome with a sensitivity of 63% and specificity of 89%.
  
  
  CONCLUSIONS
  Cord blood NRBC are significantly raised in preeclampsia. Neonates with elevated cord blood NRBC counts are more likely to have IUGR, low birth weight, neonatal ICU admission, respiratory distress syndrome, and assisted ventilation. Below the count of 13/100 leucocytes, adverse neonatal outcome is quite less likely.
authors.affiliation: Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal University, Manipal 576 104, India.
authors.forename: Shripad
authors.identifier: 0000-0001-6826-7017
authors.initials: S
authors.lastname: Hebbar
authors.affiliation: Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal University, Manipal 576 104, India.
authors.forename: Mehak
authors.initials: M
authors.lastname: Misha
authors.affiliation: Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal University, Manipal 576 104, India.
authors.forename: Lavanya
authors.initials: L
authors.lastname: Rai
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004900:Erythroblasts / Q000166:cytology*; D004906:Erythrocyte Count; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D005317:Fetal Growth Retardation / Q000097:blood*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data; D007958:Leukocyte Count; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood*; D055815:Young Adult
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