title: The brain-stomach connection.
abstract: The stomach-brain connection has been revealed to be one of the most promising targets in treating obesity. The stomach plays a key role in the homeostatic mechanism implicating stomach-brain communication regulated under neural and hormonal control. The present review explores specific topics related to gut-brain interactions focus on the stomach-brain connection through the different known systems implied in energy balance control as ghrelin, and nesfatin. Moreover, novel mechanisms for energy balance regulation involving gastric-brain communication are described including the role of the gastric intracellular mTOR/S6K1 pathway mediating the interaction among ghrelin, nesfatin and endocannabinoid gastric systems to modulate metabolism.
authors.affiliation: Grupo Fisiopatologia Endocrina, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Folgueira
authors.forename: L M
authors.initials: LM
authors.lastname: Seoane
authors.forename: F F
authors.initials: FF
authors.lastname: Casanueva
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000097:blood; D004268:DNA-Binding Proteins / Q000097:blood; D063388:Endocannabinoids / Q000097:blood; D004734:Energy Metabolism / Q000502:physiology*; D017615:Enteric Nervous System / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D054439:Ghrelin / Q000097:blood; D006801:Humans; D020738:Leptin / Q000097:blood*; D009419:Nerve Tissue Proteins / Q000097:blood; D000080866:Nucleobindins
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D063388:Endocannabinoids; D054439:Ghrelin; D020738:Leptin; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins