title: The immune injury effects and clinical significance of eosinophils in auto-immune-related hematocytopenia.
abstract: Eosinophils (EOS) quantity, active state, peroxidase activity (POX), and HLA-DR expression in bone marrow of 176 Auto-Immune-Related Hematocytopenia (AIRH) patients were analyzed. Immunofluorescent staining (IF) is performed to observe the expression of immunizing molecules on EOS. In serum of AIRH patients the levels of IL-4, IL-5, IL-6, IL-12, IL-17, and IFN- γ were increased but there was no significance on IL-2 level. In marrow of AIRH, activated EOS expressed POX, and other molecules, it played various cell-mediated immunity injury roles to hemocyte. EOS might be possessed with multiple immunological fuctions, it playes an important immune effect in AIRH autoimmune pathological processes.
authors.affiliation: a Department of Tumor Research and Treatment Centricity , People's Liberation Army No. 148 Hospital , Zibo , Shandong Province , China.
authors.forename: Li-Fei
authors.initials: LF
authors.lastname: Sun
authors.forename: Bing
authors.initials: B
authors.lastname: Han
authors.forename: Qiang-Qiang
authors.initials: QQ
authors.lastname: Wu
authors.forename: Gui-Chen
authors.initials: GC
authors.lastname: Wang
authors.forename: Hong-Feng
authors.initials: HF
authors.lastname: Hao
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Du
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D016207:Cytokines / Q000097:blood / Q000276:immunology; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D006402:Hematologic Diseases / Q000097:blood / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D055815:Young Adult
chemical_list: D016207:Cytokines
keywords: Auto-Immune-Related Hematocytopenia; IFN-γ; IL-17A; eosinophile; granzyme; perforin