title: Management of Acute Myeloid Leukemia in the Intensive Care Setting.
abstract: Patients with acute myeloid leukemia (AML) who are newly diagnosed or relapsed and those who are receiving cytotoxic chemotherapy are predisposed to conditions such as sepsis due to bacterial and fungal infections, coagulopathies, hemorrhage, metabolic abnormalities, and respiratory and renal failure. These conditions are common reasons for patients with AML to be managed in the intensive care unit (ICU). For patients with AML in the ICU, providers need to be aware of common problems and how to manage them. Understanding the pathophysiology of complications and the recent advances in risk stratification as well as newer therapy for AML are relevant to the critical care provider.
authors.affiliation: Division of Hematology, University of Washington, Seattle, WA, USA Division of Medical Oncology, University of Washington, Seattle, WA, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Cowan
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Altemeier
authors.affiliation: Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Johnston
authors.affiliation: Division of Hematology, University of Washington, Seattle, WA, USA Puget Sound Blood Center, Seattle, WA, USA.
authors.forename: Terry
authors.initials: T
authors.lastname: Gernsheimer
authors.affiliation: Division of Hematology, University of Washington, Seattle, WA, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA pbecker@u.washington.edu.
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Becker
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D003422:Critical Care; D006402:Hematologic Diseases / Q000209:etiology; D006801:Humans; D007362:Intensive Care Units; D020300:Intracranial Hemorrhages / Q000209:etiology; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000628:therapy*; D008659:Metabolic Diseases / Q000209:etiology; D011379:Prognosis; D012131:Respiratory Insufficiency / Q000209:etiology; D018805:Sepsis / Q000209:etiology
keywords: intensive care unit; respiratory failure; subdural hemorrhage; tumor lysis syndrome