title: The cytoplasmic side of p53's oncosuppressive activities.
abstract: The tumor suppressor p53 is a transcription factor that in response to a plethora of stress stimuli activates a complex and context-dependent cellular response ultimately protecting genome integrity. In the last two decades, the discovery of cytoplasmic p53 localization has driven an intense research on its extra-nuclear functions. The ability to induce apoptosis acting directly at mitochondria and the related mechanisms of p53 localization and translocation in the cytoplasm and mitochondria have been dissected. However, recent works indicate the involvement of cytoplasmic p53 also in biological processes such as autophagy, metabolism, oxidative stress and drug response. This review will focus on the mechanisms of cytoplasmic p53 activation and the pathophysiological role of p53's transcription-independent functions, highlighting possible therapeutic implications.
authors.affiliation: Laboratorio Nazionale CIB (LNCIB), Area Science Park, 34149 Trieste, Italy; Dipartimento di Scienze della Vita, Università degli Studi di Trieste, 34127, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Comel
authors.affiliation: Laboratorio Nazionale CIB (LNCIB), Area Science Park, 34149 Trieste, Italy; Dipartimento di Scienze della Vita, Università degli Studi di Trieste, 34127, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sorrentino
authors.affiliation: Laboratorio Nazionale CIB (LNCIB), Area Science Park, 34149 Trieste, Italy; Dipartimento di Scienze della Vita, Università degli Studi di Trieste, 34127, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Capaci
authors.affiliation: Laboratorio Nazionale CIB (LNCIB), Area Science Park, 34149 Trieste, Italy; Dipartimento di Scienze della Vita, Università degli Studi di Trieste, 34127, Italy. Electronic address: delsal@lncib.it.
authors.forename: Giannino
authors.initials: G
authors.lastname: Del Sal
mesh_terms: D000818:Animals; D016923:Cell Death; D003593:Cytoplasm / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D018384:Oxidative Stress; D021381:Protein Transport; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53
keywords: Apoptosis; Cytoplasm; Metabolism; Mitochondria; Transcription-independent; p53