title: Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer.
abstract: BACKGROUND
  Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC.
  
  
  METHODS
  Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC.
  
  
  RESULTS
  rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS).
  
  
  CONCLUSIONS
  Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC.
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, The University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors.forename: Hanna K
authors.initials: HK
authors.lastname: Sanoff
authors.affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Renfro
authors.affiliation: School of Medicine, The University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Poonnen
authors.affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Pratibha
authors.initials: P
authors.lastname: Ambadwar
authors.affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Sargent
authors.affiliation: Division of Medical Oncology, The Ohio State University, Columbus, Ohio, United States of America.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Goldberg
authors.affiliation: DeBartolo Family Personalized Medicine Institute, Division of Population Sciences, Moffitt Cancer Center, Tampa, Florida, United States of America.
authors.forename: Howard
authors.initials: H
authors.lastname: McLeod
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005838:Genotype; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D040641:Quantitative Trait Loci; D016896:Treatment Outcome
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