title: Hepatoprotective sesquiterpenes and rutinosides from Murraya koenigii (L.) Spreng.
abstract: Three new sesquiterpenes (1-3) and two new rutinosides (4 and 5) along with 17 known compounds (6-22) were isolated from the leaves of Murraya koenigii (L.) Spreng. The new compounds were elucidated as (3R,5S,6R)-3,5,6-trihydroxy-1,1,5-trimethylcyclohexyl-8-butyn-9-one (1), (8E,9R)-ethyl-7-(3S,5R,6S)-3,6-dihydroxy-1,1,5-trimethylcyclohexyl-9-hydroxybut-8-enoate (2), (3R)-3-O-β-D-glucoside-6'-D-apiose-β-ionone (3), 4-O-β-D-rutinosyl-3-methoxyphenyl-1-propanone (4), and 1-O-β-D-rutinosyl-2(R)-ethyl-1-pentanol (5) based on their spectroscopic data. Compounds 1, 4, 5, 18, and 21 (10 μM) exhibited moderate hepatoprotective activities.
authors.affiliation: College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University , Nanyan 473061, People's Republic of China.
authors.forename: Qin-Ge
authors.initials: QG
authors.lastname: Ma
authors.forename: Yan-Gai
authors.initials: YG
authors.lastname: Wang
authors.forename: Wen-Min
authors.initials: WM
authors.lastname: Liu
authors.forename: Rong-Rui
authors.initials: RR
authors.lastname: Wei
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Yang
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Wang
authors.forename: Teng-Fei
authors.initials: TF
authors.lastname: Ji
authors.forename: Jin
authors.initials: J
authors.lastname: Tian
authors.forename: Ya-Lun
authors.initials: YL
authors.lastname: Su
mesh_terms: D002460:Cell Line; D022781:Hepatocytes / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D032101:Murraya / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D020011:Protective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012431:Rutin / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D012717:Sesquiterpenes; D012431:Rutin
keywords: Murraya koenigii; hepatoprotective activity; rutinoside; sesquiterpene