title: Inflammatory cytokines in pulmonary hypertension.
abstract: Pulmonary hypertension is an "umbrella term" used for a spectrum of entities resulting in an elevation of the pulmonary arterial pressure. Clinical symptoms include dyspnea and fatigue which in the absence of adequate therapeutic intervention may lead to progressive right heart failure and death. The pathogenesis of pulmonary hypertension is characterized by three major processes including vasoconstriction, vascular remodeling and microthrombotic events. In addition accumulating evidence point to a cytokine driven inflammatory process as a major contributor to the development of pulmonary hypertension.This review summarizes the latest clinical and experimental developments in inflammation associated with pulmonary hypertension with special focus on Interleukin-6, and its role in vascular remodeling in pulmonary hypertension.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Groth
authors.forename: Bart
authors.initials: B
authors.lastname: Vrugt
authors.forename: Matthias
authors.initials: M
authors.lastname: Brock
authors.forename: Rudolf
authors.initials: R
authors.lastname: Speich
authors.forename: Silvia
authors.initials: S
authors.lastname: Ulrich
authors.affiliation: Division of Pulmonology, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland. lars.huber@usz.ch.
authors.forename: Lars C
authors.initials: LC
authors.lastname: Huber
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000502:physiology*
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators
references.citation: Prog Cardiovasc Dis. 2002 Nov-Dec;45(3):225-34
references.pmid: 12525998
references.citation: Am J Respir Crit Care Med. 2012 Nov 1;186(9):897-908
references.pmid: 22955318
references.citation: Rev Port Cardiol. 2008 Mar;27(3):341-8
references.pmid: 18551920
references.citation: Br J Pharmacol. 2009 Jul;157(6):922-30
references.pmid: 19508396
references.citation: Circ Res. 2009 Jan 30;104(2):236-44, 28p following 244
references.pmid: 19074475
references.citation: Am J Respir Cell Mol Biol. 1994 Dec;11(6):664-75
references.pmid: 7946395
references.citation: Angiology. 2010 Nov;61(8):802-6
references.pmid: 20498147
references.citation: Heart Dis. 1999 Jul-Aug;1(3):126-32
references.pmid: 11720614
references.citation: Circ Res. 2004 Feb 20;94(3):353-61
references.pmid: 14670842
references.citation: Am J Respir Crit Care Med. 2002 Feb 15;165(4):534-9
references.pmid: 11850348
references.citation: Case Rep Rheumatol. 2012;2012:537613
references.pmid: 22973530
references.citation: Trends Cardiovasc Med. 2011 Aug;21(6):166-71
references.pmid: 22814424
references.citation: J Heart Lung Transplant. 2012 Aug;31(8):865-73
references.pmid: 22658713
references.citation: N Engl J Med. 2004 Oct 14;351(16):1655-65
references.pmid: 15483284
references.citation: J Intern Med. 1997 Aug;242(2):185-8
references.pmid: 9279297
references.citation: Vascul Pharmacol. 2013 Jan;58(1-2):71-7
references.pmid: 22846229
references.citation: Circ Res. 2007 Sep 28;101(7):734-41
references.pmid: 17673672
references.citation: FASEB J. 2004 Nov;18(14):1746-8
references.pmid: 15364894
references.citation: Immunobiology. 2009;214(7):601-12
references.pmid: 19268389
references.citation: Chest. 2009 Sep;136(3):678-687
references.pmid: 19349390
references.citation: Hum Pathol. 1997 Apr;28(4):434-42
references.pmid: 9104943
references.citation: Am J Respir Crit Care Med. 2002 May 15;165(10):1419-25
references.pmid: 12016106
references.citation: J Interferon Cytokine Res. 2006 Sep;26(9):661-7
references.pmid: 16978070
references.citation: J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D34-41
references.pmid: 24355639
references.citation: J Biol Chem. 2011 Nov 18;286(46):40142-50
references.pmid: 21953462
references.citation: Am J Physiol Lung Cell Mol Physiol. 2011 Jul;301(1):L50-9
references.pmid: 21498626
references.citation: J Appl Physiol (1985). 1992 Aug;73(2):708-12
references.pmid: 1400001
references.citation: Clin Exp Allergy. 2003 Jul;33(7):921-9
references.pmid: 12859448
references.citation: J Mol Med (Berl). 2011 Aug;89(8):771-83
references.pmid: 21809123
references.citation: Am J Physiol Lung Cell Mol Physiol. 2001 Jan;280(1):L39-49
references.pmid: 11133493
references.citation: Clin Exp Rheumatol. 2011 Mar-Apr;29(2 Suppl 65):S46-52
references.pmid: 21586218
references.citation: Eur Respir J. 2009 Sep;34(3):662-8
references.pmid: 19324949
references.citation: Am J Respir Crit Care Med. 2012 Aug 1;186(3):261-72
references.pmid: 22679007
references.citation: Chest. 2012 Jan;141(1):210-221
references.pmid: 22215829
references.citation: Am J Respir Crit Care Med. 2012 Feb 15;185(4):409-19
references.pmid: 22161164
references.citation: Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L1014-22
references.pmid: 22387295
references.citation: Circulation. 2010 Aug 31;122(9):920-7
references.pmid: 20713898
references.citation: Respir Res. 2009 Jan 27;10:6
references.pmid: 19173740
references.citation: Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8
references.pmid: 16361357
references.citation: Proc Am Thorac Soc. 2006 Aug;3(6):475-476
references.pmid: 16921112
references.citation: J Biol Chem. 2009 Dec 4;284(49):34342-54
references.pmid: 19833726
references.citation: Am J Respir Crit Care Med. 2004 Oct 15;170(8):911-9
references.pmid: 15215156
references.citation: Eur Heart J. 2014 Dec 1;35(45):3203-11
references.pmid: 22450430
references.citation: Curr Vasc Pharmacol. 2009 Apr;7(2):234-43
references.pmid: 19356007
references.citation: Respirology. 2003 Dec;8(4):467-72
references.pmid: 14629650
references.citation: Chest. 2006 Aug;130(2):326-33
references.pmid: 16899829
references.citation: Am J Physiol Lung Cell Mol Physiol. 2002 Oct;283(4):L717-25
references.pmid: 12225948
references.citation: J Am Coll Cardiol. 1986 Dec;8(6):1307-11
references.pmid: 2431019
references.citation: Prostaglandins Leukot Essent Fatty Acids. 1997 Mar;56(3):185-92
references.pmid: 9089796
references.citation: J Clin Invest. 2003 Jun;111(12):1863-74
references.pmid: 12813022
references.citation: Chest. 2005 Dec;128(6 Suppl):572S-573S
references.pmid: 16373831
references.citation: Circulation. 2011 May 10;123(18):1986-95
references.pmid: 21518986
references.citation: Compr Physiol. 2011 Apr;1(2):769-82
references.pmid: 23737202
references.citation: Blood. 2007 Feb 1;109(3):886-95
references.pmid: 17018859
references.citation: Circulation. 2003 Jul 1;107(25):3133-40
references.pmid: 12796126
references.citation: Respir Physiol. 1998 Mar;111(3):301-10
references.pmid: 9628235
references.citation: Circ Res. 2009 May 22;104(10):1184-91
references.pmid: 19390056
references.citation: Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15;304(2):L112-24
references.pmid: 23125252
references.citation: Respir Res. 2008 Feb 12;9:20
references.pmid: 18269757
references.citation: Am J Respir Crit Care Med. 1995 May;151(5):1628-31
references.pmid: 7735624
references.citation: Hepatology. 2008 Jul;48(1):196-203
references.pmid: 18537192
references.citation: Angiogenesis. 2005;8(1):63-71
references.pmid: 16132619
references.citation: Am J Pathol. 2010 Sep;177(3):1549-61
references.pmid: 20671265
references.citation: Respirology. 2013 Nov;18(8):1271-7
references.pmid: 23819819
references.citation: Am J Respir Crit Care Med. 1999 Jun;159(6):1925-32
references.pmid: 10351941
references.citation: Nat Rev Immunol. 2004 Aug;4(8):583-94
references.pmid: 15286725
references.citation: Arterioscler Thromb Vasc Biol. 2007 May;27(5):1072-8
references.pmid: 17347486
references.citation: Asian J Surg. 2002 Jul;25(3):203-8
references.pmid: 12376215