title: Idiopathic thrombocytopenic purpura after mastectomy and axillary lymph node dissection.
abstract: First described in 1916, idiopathic thrombocytopenic purpura (ITP) is an autoimmune disease resulting in the destruction of platelets. Here, we present a case of an 85-year-old patient diagnosed with invasive ductal carcinoma of the breast whose surgical treatment was complicated postoperatively by acute-onset thrombocytopenia with a resultant hematoma at the operative site. Diagnostic Workup revealed no clear etiology for the thrombocytopenia; therefore, a presumptive diagnosis of idiopathic thrombocytopenic purpura was made. Previous literature has associated the development of idiopathic thrombocytopenic purpura with breast cancer. However, to the authors' knowledge, there are no reported cases of ITP presenting immediately following surgical intervention for breast cancer in the absence of other etiologic factors.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, The Ohio State University College of Medicine, N924 Doan Hall, 410 W 10th Avenue, Columbus, OH 43210, USA.
authors.forename: Wil L
authors.initials: WL
authors.lastname: Santivasi
authors.affiliation: Division of Surgical Oncology, Department of Surgery, The Ohio State University College of Medicine, N924 Doan Hall, 410 W 10th Avenue, Columbus, OH 43210, USA.
authors.forename: Meghan M
authors.initials: MM
authors.lastname: Routt
authors.affiliation: Division of Surgical Oncology, Department of Surgery, The Ohio State University College of Medicine, N924 Doan Hall, 410 W 10th Avenue, Columbus, OH 43210, USA.
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Terando
references.citation: Haematologica. 2006 Aug;91(8):1041-5
references.pmid: 16885043
references.citation: South Med J. 2002 Nov;95(11):1335-7
references.pmid: 12540004
references.citation: Am J Clin Oncol. 2004 Aug;27(4):333-6
references.pmid: 15289724
references.citation: J Thromb Haemost. 2012 Oct;10(10):1988-98
references.pmid: 22863415
references.citation: Am J Clin Pathol. 1992 Apr;97(4):484-9
references.pmid: 1553912
references.citation: Cancer. 1976 Apr;37(4):1999-2004
references.pmid: 944086
references.citation: Br J Haematol. 2011 May;153(4):437-50
references.pmid: 21466538
references.citation: J Res Med Sci. 2010 Nov;15(6):359-63
references.pmid: 21526109
references.citation: Am J Clin Oncol. 1999 Aug;22(4):411-3
references.pmid: 10440202
references.citation: Blood. 2004 Nov 1;104(9):2623-34
references.pmid: 15217831
references.citation: Eur J Haematol. 2009 Aug;83(2):83-9
references.pmid: 19245532