title: Innate and adaptive immune interactions at the fetal-maternal interface in healthy human pregnancy and pre-eclampsia.
abstract: Maternal immune tolerance of the fetus is indispensable for a healthy pregnancy outcome. Nowhere is this immune tolerance more important than at the fetal-maternal interface - the decidua, the site of implantation, and placentation. Indeed, many lines of evidence suggest an immunological origin to the common pregnancy-related disorder, pre-eclampsia. Within the innate immune system, decidual NK cells and antigen presenting cells (including dendritic cells and macrophages) make up a large proportion of the decidual leukocyte population, and are thought to modulate vascular remodeling and trophoblast invasion. On the other hand, within the adaptive immune system, Foxp3(+) regulatory T cells are crucial for ensuring immune tolerance toward the semi-allogeneic fetus. Additionally, another population of CD4(+)HLA-G(+) suppressor T cells has also been identified as a potential player in the maintenance of immune tolerance. More recently, studies are beginning to unravel the potential interactions between the innate and the adaptive immune system within the decidua, that are required to maintain a healthy pregnancy. In this review, we discuss the recent advances exploring the complex crosstalk between the innate and the adaptive immune system during human pregnancy.
authors.affiliation: Charles Perkins Centre Nepean , Penrith, NSW , Australia ; Department of Allergy and Immunology, The Children's Hospital at Westmead , Sydney, NSW , Australia ; Sydney Medical School, The University of Sydney , Sydney, NSW , Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Hsu
authors.affiliation: Charles Perkins Centre Nepean , Penrith, NSW , Australia ; Sydney Medical School, The University of Sydney , Sydney, NSW , Australia.
authors.forename: Ralph Kay Heinrich
authors.initials: RK
authors.lastname: Nanan
keywords: CD4+HLA-G+; NK cells; T regulatory cells; decidual; dendritic cells; pre-eclampsia; pregnancy
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