title: [Parodontitis pathogenetic factors, their interaction and effects].
abstract: Induced by microbial intervention oxidative stress causes electronic transport disorder in gingival cells mitochondrias as well as decrease of energogenesis and increase of lipoperoxidation. In oral cavity local immunity is decreased in parodontitis, that is related with immunoglobulin A deficiency and lysozyme activity decrease. Against this background, microbial factors damaging effect on periodont is intensified. In parodontitis the free nitric oxide (NO) content decrease in gingival tissues and its appearance in saliva is related with transformation of NO into toxic peroxinitrite, that on its turn enhances oxidation, parodontal injury, cell degra dation and necrosis. Nitrooxide defficiency in gingival mucosal cells is characterized by decreased protein P-53 expression and terminal differentiation disorder of the cells. Mitochodria related energogenesis disorder in gums causes inhibition of their cell regeneration, which together with apoptotic changes is characterized with parodontal tissue destruction and depletion.
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: Nana V
authors.initials: NV
authors.lastname: Kipiani
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Iverieli
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Mosemgvdlishvili
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: Nino V
authors.initials: NV
authors.lastname: Kipiani
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: S
authors.initials: S
authors.lastname: Jafaridze
mesh_terms: D017209:Apoptosis / Q000235:genetics; D004578:Electron Spin Resonance Spectroscopy; D005290:Ferric Compounds / Q000032:analysis / Q000378:metabolism*; D005786:Gene Expression Regulation; D016158:Genes, p53; D005881:Gingiva / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D015227:Lipid Peroxidation; D008345:Manganese / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009055:Mouth / Q000378:metabolism / Q000382:microbiology; D009569:Nitric Oxide / Q000097:blood* / Q000378:metabolism; D018384:Oxidative Stress; D010518:Periodontitis / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology*; D012016:Reference Values; D012463:Saliva / Q000276:immunology
chemical_list: D005290:Ferric Compounds; D007070:Immunoglobulin A; D009569:Nitric Oxide; D008345:Manganese