title: Evaluation of meniscal mechanics and proteoglycan content in a modified anterior cruciate ligament transection model.
abstract: Post-traumatic osteoarthritis (PTOA) develops as a result of traumatic loading that causes tears of the soft tissues in the knee. A modified transection model, where the anterior cruciate ligament (ACL) and both menisci were transected, was used on skeletally mature Flemish Giant rabbits. Gross morphological assessments, elastic moduli, and glycosaminoglycan (GAG) coverage of the menisci were determined to quantify the amount of tissue damage 12 weeks post injury. This study is one of the first to monitor meniscal changes after inducing combined meniscal and ACL transections. A decrease in elastic moduli as well as a decrease in GAG coverage was seen.
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Fischenich
authors.forename: Garrett A
authors.initials: GA
authors.lastname: Coatney
authors.forename: John H
authors.initials: JH
authors.lastname: Haverkamp
authors.forename: Keith D
authors.initials: KD
authors.lastname: Button
authors.forename: Charlie
authors.initials: C
authors.lastname: DeCamp
authors.forename: Roger C
authors.initials: RC
authors.lastname: Haut
authors.forename: Tammy L
authors.initials: TL
authors.lastname: Haut Donahue
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000378:metabolism*; D000070598:Anterior Cruciate Ligament Injuries; D001696:Biomechanical Phenomena; D055119:Elastic Modulus; D006025:Glycosaminoglycans / Q000378:metabolism; D055595:Mechanical Phenomena; D008592:Menisci, Tibial; D011509:Proteoglycans / Q000378:metabolism*; D011817:Rabbits
chemical_list: D006025:Glycosaminoglycans; D011509:Proteoglycans
references.citation: Osteoarthritis Cartilage. 2010 May;18(5):691-8
references.pmid: 20175978
references.citation: Anat Rec (Hoboken). 2010 Dec;293(12):1991-2000
references.pmid: 21077170
references.citation: Arthritis Rheum. 2004 Feb;50(2):543-52
references.pmid: 14872497
references.citation: Br Med J. 1968 Jun 1;2(5604):525-7
references.pmid: 5724449
references.citation: Arthritis Rheum. 1983 Jan;26(1):69-76
references.pmid: 6401994
references.citation: Osteoarthritis Cartilage. 2004 Dec;12(12):986-96
references.pmid: 15564066
references.citation: Am J Sports Med. 2014 Feb;42(2):492-9
references.pmid: 23928319
references.citation: J Bone Joint Surg Br. 1975 Aug;57(3):349-52
references.pmid: 1158945
references.citation: J Orthop Res. 2008 Jul;26(7):951-6
references.pmid: 18271010
references.citation: Clin Orthop Relat Res. 1994 Sep;(306):34-45
references.pmid: 8070209
references.citation: Am J Sports Med. 2001 Mar-Apr;29(2):151-60
references.pmid: 11292039
references.citation: Clin Orthop Relat Res. 1978 Mar-Apr;(131):279-87
references.pmid: 657636
references.citation: J Am Acad Orthop Surg. 2002 May-Jun;10(3):168-76
references.pmid: 12041938
references.citation: Am J Sports Med. 2001 Jul-Aug;29(4):415-9
references.pmid: 11476378
references.citation: Am J Orthop (Belle Mead NJ). 1997 Jan;26(1):18-23
references.pmid: 9021030
references.citation: J Bone Joint Surg Br. 1948 Nov;30B(4):664-70
references.pmid: 18894618
references.citation: J Anat. 2010 Mar;216(3):279-91
references.pmid: 20070426
references.citation: Clin Sports Med. 1990 Jul;9(3):681-94
references.pmid: 2199077
references.citation: AJR Am J Roentgenol. 1991 Oct;157(4):799-806
references.pmid: 1892040
references.citation: Bone. 2006 Feb;38(2):234-43
references.pmid: 16185945
references.citation: AJR Am J Roentgenol. 1994 Apr;162(4):905-11
references.pmid: 8141016
references.citation: Am J Sports Med. 2004 Sep;32(6):1479-83
references.pmid: 15310574
references.citation: J Bone Joint Surg Br. 1977 Feb;59(1):24-35
references.pmid: 576611
references.citation: Radiol Clin North Am. 2004 Jan;42(1):1-9, v
references.pmid: 15049520
references.citation: Br J Sports Med. 2011 Jun;45(7):583-8
references.pmid: 20647299
references.citation: J Bone Joint Surg Br. 1976 Feb;58(1):94-101
references.pmid: 131804
references.citation: Osteoarthritis Cartilage. 2002 Apr;10(4):321-6
references.pmid: 11950255
references.citation: BMC Musculoskelet Disord. 2008 Feb 12;9:20
references.pmid: 18269731
references.citation: Osteoarthritis Cartilage. 2011 Sep;19(9):1132-41
references.pmid: 21683797
references.citation: Ann Rheum Dis. 2004 Mar;63(3):269-73
references.pmid: 14962961
references.citation: J Surg Res. 2010 Dec;164(2):234-41
references.pmid: 19577765
references.citation: Clin Orthop Relat Res. 1983 Jan-Feb;(172):32-7
references.pmid: 6822002
references.citation: Arthritis Rheum. 1984 Apr;27(4):388-97
references.pmid: 6712755
references.citation: J Orthop Res. 2013 Nov;31(11):1745-56
references.pmid: 23832294
references.citation: J Orthop Res. 2000 Sep;18(5):739-48
references.pmid: 11117295
references.citation: Clin Orthop Relat Res. 1990 Mar;(252):19-31
references.pmid: 2406069
references.citation: Osteoarthritis Cartilage. 1997 Sep;5(5):357-72
references.pmid: 9497942
references.citation: Biorheology. 2009;46(3):227-37
references.pmid: 19581729
references.citation: J Bone Joint Surg Am. 2006 Aug;88(8):1826-34
references.pmid: 16882908
references.citation: Open Rheumatol J. 2012;6:24-32
references.pmid: 22550551
references.citation: Knee Surg Sports Traumatol Arthrosc. 2008 May;16(5):442-8
references.pmid: 18292988
references.citation: Osteoarthritis Cartilage. 2001 Jan;9(1):56-64
references.pmid: 11178948
references.citation: Arthroscopy. 2004 May;20(5):474-81
references.pmid: 15122137
references.citation: Clin Sports Med. 1993 Oct;12(4):771-96
references.pmid: 8261525
references.citation: Ann Biomed Eng. 2004 Nov;32(11):1569-79
references.pmid: 15636116
references.citation: Osteoarthritis Cartilage. 2005 Feb;13(2):139-45
references.pmid: 15694575
references.citation: BMC Musculoskelet Disord. 2011 Aug 24;12:197
references.pmid: 21864409
references.citation: J Bone Joint Surg Am. 1986 Jan;68(1):71-9
references.pmid: 3753605
references.citation: J Bone Joint Surg Am. 1980 Jul;62(5):696-705
references.pmid: 7391092
references.citation: J Orthop Res. 2000 Jan;18(1):109-15
references.pmid: 10716286
references.citation: J Bone Joint Surg Am. 1971 Jan;53(1):69-82
references.pmid: 4250366
references.citation: Osteoarthritis Cartilage. 2010 Feb;18(2):184-91
references.pmid: 19815108
references.citation: Arthritis Rheum. 1988 Apr;31(4):538-44
references.pmid: 3358811
references.citation: J Bone Joint Surg Am. 1969 Apr;51(3):517-26 passim
references.pmid: 5778287
references.citation: Osteoarthritis Cartilage. 2003 Dec;11(12):891-902
references.pmid: 14629965
references.citation: J Orthop Res. 2000 May;18(3):383-92
references.pmid: 10937624
references.citation: Osteoarthritis Cartilage. 1996 Jun;4(2):87-98
references.pmid: 8806111
references.citation: Am J Sports Med. 1988 Nov-Dec;16(6):603-9
references.pmid: 3239617
references.citation: J Appl Physiol (1985). 2011 Dec;111(6):1590-6
references.pmid: 21903884