title: The neural substrates of self-evaluation of mental fatigue: a magnetoencephalography study.
abstract: There have been several studies of the neural mechanisms underlying sensation of fatigue. However, little is known about the neural mechanisms underlying self-evaluation of the level of fatigue. The aim of this study was to identify the neural substrates involved in self-evaluation of the level of mental fatigue. We used magnetoencephalography (MEG) with high temporal resolution on 14 healthy participants. During MEG recordings, participants were asked to evaluate their level of mental fatigue in time with execution cues (evaluation trials) or to do nothing in time with execution cues (control trials). The MEG data were analyzed with equivalent current dipole (ECD) and spatial filtering methods to localize the neural activity related to the evaluation of mental fatigue. The daily level of fatigue sensation was assessed using the Checklist Individual Strength questionnaire. In evaluation trials, ECDs were observed in the posterior cingulate cortex (PCC) in seven of 14 participants, with a mean latency of 366.0 ms. The proportion of the participants with ECDs in the PCC was higher in evaluation trials than in control trials (P<0.05, McNemar test). The extent of the decreased delta band power in the PCC (Brodmann's area 31) 600-700 ms after the onset of the execution cue and that in the dorsolateral prefrontal cortex (DLPFC; Brodmann's area 9) 800-900 ms after the onset of the execution cue were greater in the evaluation trials than in the control trials. The decrease in delta band power in the DLPFC was positively related to that in the PCC and to the daily level of fatigue sensation. These data suggest that the PCC and DLPFC are involved in the self-evaluation of mental fatigue.
authors.affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ishii
authors.affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan; RIKEN, Center for Life Science Technologies, Kobe, Japan.
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D005222:Mental Fatigue / Q000175:diagnosis* / Q000503:physiopathology*; D055815:Young Adult
references.citation: J Sleep Res. 1995 Dec;4(S2):4-14
references.pmid: 10607205
references.citation: Clin Neurophysiol. 2012 Oct;123(10):2042-9
references.pmid: 22538122
references.citation: Hum Brain Mapp. 2005 Jun;25(2):199-211
references.pmid: 15846771
references.citation: J Psychosom Res. 1998 Jul;45(1):53-65
references.pmid: 9720855
references.citation: Neuroscience. 2014 Mar 7;261:60-7
references.pmid: 24388922
references.citation: Soc Cogn Affect Neurosci. 2014 Mar;9(3):307-15
references.pmid: 23202660
references.citation: Neuroimage. 2006 Apr 15;30(3):753-67
references.pmid: 16368248
references.citation: Clin Neurophysiol. 1999 Nov;110(11):1842-57
references.pmid: 10576479
references.citation: Ind Health. 2006 Oct;44(4):537-40
references.pmid: 17085914
references.citation: Neuroimage. 2006 Jan 15;29(2):452-66
references.pmid: 16140550
references.citation: Occup Environ Med. 2000 May;57(5):353-7
references.pmid: 10769302
references.citation: Neurol Res Int. 2010;2010:671421
references.pmid: 21188225
references.citation: Behav Res Methods. 2012 Jun;44(2):314-24
references.pmid: 22083660
references.citation: Neuroimage. 2007 Jul 1;36(3):706-17
references.pmid: 17524669
references.citation: J Neurophysiol. 2009 Feb;101(2):875-87
references.pmid: 19073802
references.citation: Cancer. 2002 Jan 15;94(2):528-38
references.pmid: 11900238
references.citation: Behav Brain Funct. 2013 Jun 13;9:24
references.pmid: 23764106
references.citation: Neurosci Lett. 2006 Jan 9;392(1-2):118-23
references.pmid: 16202519
references.citation: BMJ. 1994 Mar 19;308(6931):763-6
references.pmid: 7908238
references.citation: Neuroimage. 2007 Jan 15;34(2):839-47
references.pmid: 17095252
references.citation: Psychol Med. 2008 Jul;38(7):941-51
references.pmid: 18447963
references.citation: Lancet. 2004 Mar 20;363(9413):978-88
references.pmid: 15043967
references.citation: Brain. 2002 Aug;125(Pt 8):1808-14
references.pmid: 12135971
references.citation: Neuroimage. 2006 Jul 15;31(4):1580-91
references.pmid: 16632378
references.citation: Neuroscience. 2007 Jul 13;147(3):842-52
references.pmid: 17560045
references.citation: Neuroimage. 2008 May 1;40(4):1686-700
references.pmid: 18356081
references.citation: Neuroimage. 1999 Jul;10(1):1-5
references.pmid: 10385576
references.citation: Med Hypotheses. 2010 Aug;75(2):244-9
references.pmid: 20338693
references.citation: Neurosci Lett. 2004 May 6;361(1-3):245-9
references.pmid: 15135939
references.citation: Brain Res. 2012 May 31;1457:44-50
references.pmid: 22541165
references.citation: BMJ. 1990 Nov 24;301(6762):1199-202
references.pmid: 2261560
references.citation: Cereb Cortex. 2000 Mar;10(3):295-307
references.pmid: 10731224
references.citation: Philos Trans R Soc Lond B Biol Sci. 2009 Jul 12;364(1525):1933-42
references.pmid: 19487195
references.citation: Ind Health. 1999 Apr;37(2):134-42
references.pmid: 10319563
references.citation: Eur J Public Health. 2010 Jun;20(3):251-7
references.pmid: 19689970
references.citation: PLoS One. 2013 Jul 26;8(7):e70949
references.pmid: 23923034
references.citation: Neuroimage. 2007 May 15;36(1):108-22
references.pmid: 17408973
references.citation: Pain. 1998 May;76(1-2):127-35
references.pmid: 9696465
references.citation: Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5304-9
references.pmid: 10220461
references.citation: PLoS One. 2013 Nov 20;8(11):e80731
references.pmid: 24278313
references.citation: Clin Neurophysiol. 2008 Jul;119(7):1524-33
references.pmid: 18468483
references.citation: J Epidemiol Community Health. 2010 Aug;64(8):649-50
references.pmid: 20670973
references.citation: Psychometrika. 1947 Jun;12(2):153-7
references.pmid: 20254758
references.citation: Brain Res. 2012 May 21;1455:68-74
references.pmid: 22502975
references.citation: Neuropsychologia. 1971 Mar;9(1):97-113
references.pmid: 5146491
references.citation: J Clin Neurophysiol. 2003 Apr;20(2):87-93
references.pmid: 12766680
references.citation: J Neurophysiol. 2013 May;109(9):2393-403
references.pmid: 23427303
references.citation: J Occup Health. 2007 Nov;49(6):453-60
references.pmid: 18075205
references.citation: Brain Res. 2013 Nov 6;1537:117-24
references.pmid: 24012875
references.citation: Prog Brain Res. 2005;150:205-17
references.pmid: 16186025
references.citation: Neuroimage. 2006 May 15;31(1):160-71
references.pmid: 16520063
references.citation: Comput Intell Neurosci. 2009;:549419
references.pmid: 19609455
references.citation: Nat Rev Neurosci. 2002 Aug;3(8):655-66
references.pmid: 12154366
references.citation: Neuroimage. 2005 Apr 1;25(2):369-82
references.pmid: 15784415