title: Protective effects of gallic acid against chronic cerebral hypoperfusion-induced cognitive deficit and brain oxidative damage in rats.
abstract: Free radical-induced neural damage is implicated in cerebral hypoperfusion disorders and antioxidants have protective effects. In the present study, we examined the effect of gallic acid (GA; 100mg/kg, p.o. for 10 days) on cognitive deficit and cerebral oxidative stress induced by permanent bilateral common carotid artery occlusion (2VO) as an animal model of vascular dementia (VD). The results showed that 2VO significantly reduced the spatial memory performance in Morris water maze as well as non-enzymatic (total thiol) and enzymatic [glutathione peroxidase (GPx)] antioxidant contents and increased the level of malondialdehyde (MDA) in the hippocampus and frontal cortex of vehicle-treated group as compared to sham-operated rats. Furthermore, chronic administration of GA significantly restored the spatial memory, total thiol and GPx contents and also decreased MDA levels in these tissues. GA alone did not show any change neither in the status of various antioxidants nor behavioral tests over sham values. The results demonstrate that GA has beneficial activity against 2VO-induced cognitive deficits via enhancement of cerebral antioxidant defense. Taken together, the present study suggested that GA might be useful in the treatment of VD.
authors.affiliation: Dept. of Physiology, Physiology Research Center, School of Medicine, Ahvaz Jundishapur Univ. of Med. Sciences (AJUMS), Ahvaz, Iran; Medical Plant and Cellular and Molecular Research Centers, School of Medicine, Shahrekord Univ. of Med. Sciences (SUMS), Shahrekord, Iran.
authors.forename: Mehrdad Shahrani
authors.initials: MS
authors.lastname: Korani
authors.affiliation: Dept. of Physiology, Physiology Research Center, School of Medicine, Ahvaz Jundishapur Univ. of Med. Sciences (AJUMS), Ahvaz, Iran.
authors.forename: Yaghoub
authors.initials: Y
authors.lastname: Farbood
authors.affiliation: Dept. of Physiology, Physiology Research Center, School of Medicine, Ahvaz Jundishapur Univ. of Med. Sciences (AJUMS), Ahvaz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Sarkaki
authors.affiliation: Dept. of Physiology, Physiology Research Center, School of Medicine, Ahvaz Jundishapur Univ. of Med. Sciences (AJUMS), Ahvaz, Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Fathi Moghaddam
authors.affiliation: Dept. of Pharmacology, Physiology and Atherosclerosis Research Centers, School of Medicine, Ahvaz Jundishapur Univ. of Med. Sciences (AJUMS), Ahvaz, Iran. Electronic address: mansouri_smt@yahoo.com.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Taghi Mansouri
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D002908:Chronic Disease; D003072:Cognition Disorders / Q000378:metabolism / Q000517:prevention & control* / Q000523:psychology; D004195:Disease Models, Animal; D005707:Gallic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D017208:Rats, Wistar; D065852:Spatial Memory / Q000187:drug effects
chemical_list: D000975:Antioxidants; D005707:Gallic Acid
keywords: Gallic acid; Oxidative stress; Permanent cerebral hypoperfusion; Rat; Spatial memory