title: Lateral geniculate lesions causing reversible blindness in a pre-eclamptic patient with a variant of posterior reversible encephalopathy syndrome.
abstract: Bilateral lateral geniculate nucleus (LGN) injury is a rare cause of vision loss. We describe a patient with pre-eclampsia who developed profound but reversible bilateral vision loss, bilateral serous retinal detachments, and magnetic resonance imaging signs of a variant of posterior reversible encephalopathy syndrome (PRES) that affected both LGNs and spared the retrogeniculate pathways. We provide evidence that the visual loss was not from the chorioretinal lesions but from the LGN lesions. The concurrence of PRES and lesions attributed to choroidal hypoperfusion provides support for the notion that vasoconstriction also underlies the pathogenesis of PRES.
authors.affiliation: Kellogg Eye, Department of Ophthalmology and Visual Sciences (MSS, AF, JDT), Department of Neurology (JDT), Department of Radiology (Neuroradiology) (HAP, MI), University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Maxwell S
authors.initials: MS
authors.lastname: Stem
authors.forename: Abigail
authors.initials: A
authors.lastname: Fahim
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Trobe
authors.forename: Hemant A
authors.initials: HA
authors.lastname: Parmar
authors.forename: Mohannad
authors.initials: M
authors.lastname: Ibrahim
mesh_terms: D000328:Adult; D001766:Blindness / Q000209:etiology*; D005260:Female; D005829:Geniculate Bodies / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D054038:Posterior Leukoencephalopathy Syndrome / Q000150:complications* / Q000473:pathology*; D014792:Visual Acuity