title: Shifting paradigms of nontuberculous mycobacteria in cystic fibrosis.
abstract: Important paradigms of pulmonary disease with nontuberculous mycobacteria (NTM) are currently shifting based on an increasing attention within the field of cystic fibrosis (CF). These shifts are likely to benefit the management of all patients with pulmonary NTM, regardless of underlying pathology. Currently several key areas are being revised: The first outbreak of human NTM transmission has been proven and new evidence of biofilm growth in vivo has been demonstrated. A better understanding of the clinical impact of NTM infection has led to increased diagnostic vigilance and new recommendations for lung transplantation are under way. While recent changes have reinvigorated the interest in NTM disease, the challenge remains, whether such advances can be successfully translated into improved management and care.
authors.affiliation: Department of Infectious Diseases, Cystic Fibrosis Center Copenhagen, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. tavs.qvist@gmail.com.
authors.forename: Tavs
authors.initials: T
authors.lastname: Qvist
authors.forename: Tania
authors.initials: T
authors.lastname: Pressler
authors.forename: Niels
authors.initials: N
authors.lastname: Høiby
authors.forename: Terese L
authors.initials: TL
authors.lastname: Katzenstein
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents
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