title: TFIIB-related factor 2 is associated with poor prognosis of nonsmall cell lung cancer patients through promoting tumor epithelial-mesenchymal transition.
abstract: In this study, we found that increased BRF2 protein expression was prevalent in NSCLC. Overexpression of BRF2 correlated with abnormal expression of E-cadherin, N-cadherin, and snail. Additionally, expression of BRF2 was found to be an independent prognostic factor in NSCLC patients. Furthermore, we showed that targeted knockdown of BRF2 expression could inhibit the migratory and invasive abilities of NSCLC cells and induced loss of the epithelial-mesenchymal transition of NSCLC cells. These results suggested that BRF2 overexpression in tumor tissues is significantly associated with the poor prognosis of NSCLC patients through promoting epithelial-mesenchymal transition (EMT) program.
authors.affiliation: Department of Thoracic Surgery, Qilu Hospital, School of Medicine, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Thoracic Surgery, Qilu Hospital, School of Medicine, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Lu
authors.affiliation: Department of Thoracic Surgery, Qilu Hospital, School of Medicine, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Weiming
authors.initials: W
authors.lastname: Yue
authors.affiliation: Department of Thoracic Surgery, Qilu Hospital, School of Medicine, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Qilu Hospital, School of Medicine, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Shuhai
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Qilu Hospital, School of Medicine, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Cun
authors.initials: C
authors.lastname: Gao
authors.affiliation: Department of Thoracic Surgery, Qilu Hospital, School of Medicine, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Libo
authors.initials: L
authors.lastname: Si
authors.affiliation: Department of Thoracic Surgery, Qilu Hospital, School of Medicine, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Qi
authors.affiliation: Department of Thoracic Surgery, Qilu Hospital, School of Medicine, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Wensi
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Thoracic Surgery, Qilu Hospital, School of Medicine, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Tian
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D035361:Transcription Factor TFIIIB / Q000096:biosynthesis / Q000235:genetics*
chemical_list: C416185:BRF2 protein, human; D035361:Transcription Factor TFIIIB
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