title: LDH5 overexpression is associated with poor survival in patients with solid tumors: a meta-analysis.
abstract: Lactate dehydrogenase 5 (LDH5) is believed to be particularly important and a reliable marker of malignancy. However, it is still controversial whether LDH5 expression can be regarded as a prognostic factor for cancer patients. We reviewed the literature by performing an electronic database search via PubMed to identify eligible studies that assessed the impact of LDH5 as a cancer prognostic marker and its association with HIF-1α. Heterogeneity and publication bias were also assessed. A total of 12 literatures which included 1,892 cancer patients were combined in the final analysis. Meta-analysis revealed that LDH5 overexpression was associated with an unfavorable overall survival (12 studies, 1,597 patients; HR 1.59, 95 % CI 1.17-2.16) and disease/recurrence/progression-free survival (7 studies; 1,086 patients; HR 1.46, 95 % CI 1.04-2.04) among solid tumor patients. Meta-analysis revealed an association between the expression of LDH5 and hypoxia-inducible factors 1 (OR 2.72, 95 % CI 1.66-4.45). Publication bias could not be excluded when investigating the association of LDH5 expression and overall survival. However, when we accounted for publication bias using the trim and fill method, the results remained significant (HR 1.435, 95 % CI 1.071-1.923, P < 0.05) suggesting the stability of our results. Therefore, our study suggested that LDH5 overexpression had a poor prognosis value in cancer patients. The results of this meta-analysis suggest that high LDH5 expression is associated with HIF-1α and poor overall survival in cancer patients.
authors.affiliation: Tianjin Medical University Cancer Institute and Hospital, Huanhuxi Road, Tianjin, China.
authors.forename: YanHong
authors.initials: Y
authors.lastname: Yao
authors.forename: HaiTao
authors.initials: H
authors.lastname: Wang
authors.forename: BaoGuo
authors.initials: B
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D018572:Disease-Free Survival; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics; D007527:Isoenzymes / Q000096:biosynthesis / Q000235:genetics; D007770:L-Lactate Dehydrogenase / Q000096:biosynthesis* / Q000235:genetics; D000080864:Lactate Dehydrogenase 5; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D000080864:Lactate Dehydrogenase 5
references.citation: Stat Med. 2002 Jun 15;21(11):1539-58
references.pmid: 12111919
references.citation: Clin Exp Metastasis. 2012 Jan;29(1):11-7
references.pmid: 21984395
references.citation: Anticancer Res. 2010 Apr;30(4):1347-51
references.pmid: 20530451
references.citation: Pathobiology. 2014;81(2):78-85
references.pmid: 24401755
references.citation: Lung Cancer. 2011 Jun;72(3):294-302
references.pmid: 21075472
references.citation: Melanoma Res. 2003 Oct;13(5):493-501
references.pmid: 14512791
references.citation: PLoS One. 2013 Sep 23;8(9):e74853
references.pmid: 24086384
references.citation: Clin Exp Metastasis. 2005;22(1):25-30
references.pmid: 16132575
references.citation: J Clin Oncol. 2006 Sep 10;24(26):4301-8
references.pmid: 16896001
references.citation: Leuk Lymphoma. 2008 Nov;49(11):2181-6
references.pmid: 19021062
references.citation: Diagn Pathol. 2010 Apr 12;5:22
references.pmid: 20385008
references.citation: Cancer Res. 2006 Jan 15;66(2):632-7
references.pmid: 16423989
references.citation: Ann Intern Med. 1997 Nov 1;127(9):820-6
references.pmid: 9382404
references.citation: Ann Oncol. 2011 Feb;22(2):295-300
references.pmid: 20657034
references.citation: Carcinogenesis. 2012 Sep;33(9):1717-25
references.pmid: 22777959
references.citation: Future Med Chem. 2013 Oct;5(16):1967-91
references.pmid: 24175747
references.citation: Mod Pathol. 2010 Jan;23(1):45-53
references.pmid: 19838163
references.citation: Cancer Res. 2007 Nov 1;67(21):10099-102
references.pmid: 17974948
references.citation: Melanoma Res. 2011 Jun;21(3):188-95
references.pmid: 21537144
references.citation: Tumour Biol. 2013 Jun;34(3):1523-30
references.pmid: 23404405
references.citation: Cell Metab. 2008 Jan;7(1):11-20
references.pmid: 18177721
references.citation: Cancer Biol Ther. 2006 May;5(5):476-9
references.pmid: 16627974
references.citation: Med Pregl. 2012 May-Jun;65(5-6):200-5
references.pmid: 22730703
references.citation: J Clin Pathol. 2008 Feb;61(2):217-20
references.pmid: 17513511
references.citation: J Clin Pathol. 2010 Oct;63(10):867-72
references.pmid: 20876316
references.citation: Oncology. 2009;77(5):285-92
references.pmid: 19923867
references.citation: Gynecol Oncol. 2006 Dec;103(3):912-8
references.pmid: 16837029
references.citation: Nat Rev Drug Discov. 2011 Sep 16;10(10):767-77
references.pmid: 21921921
references.citation: Ann Surg Oncol. 2008 Aug;15(8):2336-44
references.pmid: 18521687
references.citation: Tumour Biol. 2013 Feb;34(1):25-31
references.pmid: 22961700
references.citation: Br J Cancer. 2003 Dec 1;89(11):2045-50
references.pmid: 14647136
references.citation: J Biol Chem. 1996 Dec 20;271(51):32529-37
references.pmid: 8955077
references.citation: J Biol Chem. 1995 Sep 8;270(36):21021-7
references.pmid: 7673128
references.citation: Cancer Res. 2010 Feb 1;70(3):859-62
references.pmid: 20086171
references.citation: Br J Cancer. 2010 Oct 12;103(8):1209-14
references.pmid: 20842118
references.citation: Clin Cancer Res. 2011 Jul 15;17(14):4892-900
references.pmid: 21632858
references.citation: Science. 1956 Aug 10;124(3215):269-70
references.pmid: 13351639
references.citation: Clin Exp Metastasis. 2013 Apr;30(4):529-40
references.pmid: 23184277
references.citation: Int J Colorectal Dis. 2013 Mar;28(3):375-83
references.pmid: 22847606
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42
references.pmid: 20133848
references.citation: Breast Cancer Res Treat. 2012 Feb;131(3):791-800
references.pmid: 21452021
references.citation: Br J Cancer. 2003 Sep 1;89(5):877-85
references.pmid: 12942121
references.citation: Stat Med. 1998 Dec 30;17(24):2815-34
references.pmid: 9921604
references.citation: Science. 1956 Feb 24;123(3191):309-14
references.pmid: 13298683
references.citation: Cancer Cell. 2006 Jun;9(6):425-34
references.pmid: 16766262