title: Glycobiology: drifting toward polymer perfection.
abstract: The addition of polysialic acid to proteins and cells is emerging as a promising therapeutic strategy. Polysialyltransferases synthesize polymers of widely varying lengths not optimal for therapeutic reagents, but the development of enzyme variants using neutral genetic drift offers a new way to overcome this problem.
authors.affiliation: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA.
authors.forename: Karen J
authors.identifier: 000000023801071X
authors.initials: KJ
authors.lastname: Colley
mesh_terms: D038541:Neisseria meningitidis, Serogroup B / Q000201:enzymology*; D015202:Protein Engineering; D012799:Sialyltransferases / Q000737:chemistry* / Q000235:genetics*
chemical_list: D012799:Sialyltransferases
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