title: Synthesis of new thiobarbituric acid derived spiroheterobicyclic compounds and their antimicrobial activity.
abstract: A series pf novel (7S, 11R)-substituted diphenyl-2,4,8,10-tetraazaspiro [5.5] undecane-3-thio-1,5,9-triones 4a-j and (7S,11R)-substituted diphenyl-2,4,8,10-tetraazaspiro[5.5] undecane-3-thio-1,5 dione, 9-thiones 5a-j were prepared using substituted aldehydes and urea/thiourea in the presence of thiobarbituric acid under solvent free, thermal and microwave conditions catalyzed by ecofriendly K-10 clay. The antibacterial potency of these compounds in vitro on the gram negative strains Escherichia coli and Pseudomonas aeruginosa and gram positive strains Staphyllococcus aureus and Staphylococcus epidermidis was evaluated.
authors.affiliation: Department of Applied Sciences, PEC University of Technology, Chandigarh, 160012, India.
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Kaur
authors.forename: Parul
authors.initials: P
authors.lastname: Gupta
authors.forename: Kusum
authors.initials: K
authors.lastname: Harjai
authors.forename: Vasundhara
authors.initials: V
authors.lastname: Singh
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development; D013858:Thiobarbiturates / Q000737:chemistry*; D014508:Urea / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D013141:Spiro Compounds; D013858:Thiobarbiturates; D014508:Urea; C029684:thiobarbituric acid
keywords: K-10 clay; antibacterial activity; solvent-less; spiroheterobicycles; thiobarbituric acid