title: The role of radiotherapy in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline.
abstract: OBJECTIVE
  Can re-irradiation (by using conventional radiotherapy, fractionated radiosurgery, or single fraction radiosurgery) be used in patients with progressive glioblastoma multiforme after the first adjuvant combined multimodality treatment with radiation and chemotherapy?
  
  
  METHODS
  These recommendations apply to adult patients with progressive glioblastoma after first line combined multimodality treatment with chemotherapy and radiation.
  When the target tumor is amenable for additional radiation, re-irradiation is recommended as it provides improved local tumor control, as measured by best imaging response. Such re-irradiation can take the form of conventional fractionation radiotherapy, fractionated radiosurgery, or single fraction radiosurgery.
  
  
  METHODS
  Re-irradiation is recommended in order to maintain or improve a patient's neurological status and quality of life prior to any further tumor progression.
authors.affiliation: Department of Radiation Oncology, Stony Brook University School of Medicine, Stony Brook, NY, USA, samuel.ryu@stonybrookmedicine.edu.
authors.forename: Samuel
authors.initials: S
authors.lastname: Ryu
authors.forename: John M
authors.initials: JM
authors.lastname: Buatti
authors.forename: Ann
authors.initials: A
authors.lastname: Morris
authors.forename: Steven N
authors.initials: SN
authors.lastname: Kalkanis
authors.forename: Timothy Charles
authors.initials: TC
authors.lastname: Ryken
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Olson
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D016371:Cranial Irradiation; D019317:Evidence-Based Medicine; D005909:Glioblastoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D016634:Radiosurgery; D016896:Treatment Outcome
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