title: Altered hypothalamic functional connectivity with autonomic circuits and the locus coeruleus in migraine.
abstract: The hypothalamus has been implicated in migraine based on the manifestation of autonomic symptoms with the disease, as well as neuroimaging evidence of hypothalamic activation during attacks. Our objective was to determine functional connectivity (FC) changes between the hypothalamus and the rest of the brain in migraine patients vs. control subjects. This study uses fMRI (functional magnetic resonance imaging) to acquire resting state scans in 12 interictal migraine patients and 12 healthy matched controls. Hypothalamic connectivity seeds were anatomically defined based on high-resolution structural scans, and FC was assessed in the resting state scans. Migraine patients had increased hypothalamic FC with a number of brain regions involved in regulation of autonomic functions, including the locus coeruleus, caudate, parahippocampal gyrus, cerebellum, and the temporal pole. Stronger functional connections between the hypothalamus and brain areas that regulate sympathetic and parasympathetic functions may explain some of the hypothalamic-mediated autonomic symptoms that accompany or precede migraine attacks.
authors.affiliation: Pain/Analgesia Imaging Neuroscience (P.A.I.N.) Group, Department of Anesthesia, Boston Children's Hospital, Center for Pain and the Brain, Harvard Medical School, Waltham, Massachusetts, United States of America.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Moulton
authors.affiliation: Pain/Analgesia Imaging Neuroscience (P.A.I.N.) Group, Department of Anesthesia, Boston Children's Hospital, Center for Pain and the Brain, Harvard Medical School, Waltham, Massachusetts, United States of America; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.
authors.forename: Lino
authors.initials: L
authors.lastname: Becerra
authors.affiliation: Pain/Analgesia Imaging Neuroscience (P.A.I.N.) Group, Department of Anesthesia, Boston Children's Hospital, Center for Pain and the Brain, Harvard Medical School, Waltham, Massachusetts, United States of America.
authors.forename: Adriana
authors.initials: A
authors.lastname: Johnson
authors.affiliation: Anaesthesia & Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
authors.forename: Rami
authors.initials: R
authors.lastname: Burstein
authors.affiliation: Pain/Analgesia Imaging Neuroscience (P.A.I.N.) Group, Department of Anesthesia, Boston Children's Hospital, Center for Pain and the Brain, Harvard Medical School, Waltham, Massachusetts, United States of America; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America; P.A.I.N. Group, Department of Psychiatry, McLean Hospital, Center for Pain and the Brain, Harvard Medical School, Belmont, Massachusetts, United States of America.
authors.forename: David
authors.initials: D
authors.lastname: Borsook
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology; D002531:Cerebellum / Q000502:physiology; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D008125:Locus Coeruleus / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D020534:Parahippocampal Gyrus / Q000503:physiopathology; D055815:Young Adult
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