title: Bacterial translocation in alymphoplasia (aly/aly) mice.
abstract: Bacterial translocation (BTL) is defined as the passage of viable bacteria from the gastrointestinal tract to the organs. This study was to elucidate the roles of Peyer's patches (PPs) and/or mesenteric lymph nodes (MLNs) in BTL. Alymphoplastic mutant mice and phenotypically normal heterozygous micewere dominantly colonized with streptomycin-resistant Escherichia coli and BTL was examined. In PP- and MLN-competent mice, BTL to MLNs was detected in 100% of mice, but BTL to organs was rare (25%). On the other hand, in PP- and MLN-deficientmice, BTL to organs was detected in 91% of mice. The results clearly indicate that PPs are not the only site for bacterial entry.
authors.forename: Hodaka
authors.initials: H
authors.lastname: Suzuki
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Okada
mesh_terms: D000818:Animals; D018988:Bacterial Translocation / Q000235:genetics / Q000502:physiology*; D004926:Escherichia coli / Q000502:physiology; D005260:Female; D008198:Lymph Nodes / Q000002:abnormalities; D008297:Male; D051379:Mice; D010581:Peyer's Patches / Q000002:abnormalities; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D013047:Specific Pathogen-Free Organisms; D016176:T-Lymphocyte Subsets; D000097782:NF-kappaB-Inducing Kinase
chemical_list: D017346:Protein Serine-Threonine Kinases; D000097782:NF-kappaB-Inducing Kinase