title: In vitro antioxidant and cytotoxic activity of some synthetic riparin-derived compounds.
abstract: This study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the substances showed antioxidant activity and riparins C, D, E, F presented cell growth inhibition rates greater than 70%, suggesting that these molecules have antitumor properties. These substances also caused greater than 80% releases of cytoplasmic lactate dehydrogenase enzyme (LDH). Although the antioxidant and antitumor properties presented herein require further assessment, the outcomes indicate that these novel riparins are promising biologically active compounds.
authors.affiliation: Laboratory for Research in Experimental Neurochemistry, Campus Ministro Petrônio Portella, Federal University of Piauí, Teresina, PI 64049550, Brazil. geandraenf@hotmail.com.
authors.forename: Geandra B L
authors.initials: GB
authors.lastname: Nunes
authors.affiliation: Laboratory for Research in Experimental Neurochemistry, Campus Ministro Petrônio Portella, Federal University of Piauí, Teresina, PI 64049550, Brazil. paolla_dallet@hotmail.com.
authors.forename: Paola R
authors.initials: PR
authors.lastname: Policarpo
authors.affiliation: Laboratory for Research in Experimental Neurochemistry, Campus Ministro Petrônio Portella, Federal University of Piauí, Teresina, PI 64049550, Brazil. luciana.muratori@hotmail.com.
authors.forename: Luciana M
authors.initials: LM
authors.lastname: Costa
authors.affiliation: Laboratory of Bioassays for Drug Research, Federal University of Pernambuco, Recife, PE 50670-901, Brazil. teresinha.goncalves@ufpe.br.
authors.forename: Teresinha G
authors.initials: TG
authors.lastname: da Silva
authors.affiliation: Laboratory of Bioassays for Drug Research, Federal University of Pernambuco, Recife, PE 50670-901, Brazil. gcgadelha@yahoo.com.br.
authors.forename: Gardenia Carmen G
authors.initials: GC
authors.lastname: Militão
authors.affiliation: Department of Chemistry, Federal Rural University of Pernambuco, Recife, PE 52171900, Brazil. ccelso@dcm.ufrpe.br.
authors.forename: Celso A
authors.initials: CA
authors.lastname: Câmara
authors.affiliation: Laboratory of Pharmaceutical Technology Federal University of Paraíba, João Pessoa, PB 58051-900, Brazil. jbarbosa@ltf.ufpb.br.
authors.forename: José Maria
authors.initials: JM
authors.lastname: Barbosa Filho
authors.affiliation: Laboratory Chemistry of Bioactive Natural and Synthetic Products, Federal University of Piauí, Teresina, PI 64049550, Brazil. stanleychavez@yahoo.com.br.
authors.forename: Stanley Juan C
authors.initials: SJ
authors.lastname: Gutierrez
authors.affiliation: Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, Mededibag, Chittagong-4000, Bangladesh. mti031124@gmail.com.
authors.forename: Mohammed T
authors.initials: MT
authors.lastname: Islam
authors.affiliation: Laboratory for Research in Experimental Neurochemistry, Campus Ministro Petrônio Portella, Federal University of Piauí, Teresina, PI 64049550, Brazil. rivmendes@hotmail.com.
authors.forename: Rivelilson M
authors.initials: RM
authors.lastname: de Freitas
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D001549:Benzamides / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000037:antagonists & inhibitors*; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001549:Benzamides; D009569:Nitric Oxide; D008315:Malondialdehyde
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