title: miRNAs and aging: a genetic perspective.
abstract: A growing body of evidence shows that microRNA expression changes with age in animals ranging from nematode to human. Genetic studies of microRNA function in vivo provide the means to move beyond correlation and to explore cause-effect relationships. Genetic studies in Caenorhabditis elegans and Drosophila have identified cellular pathways involved in organismal aging. Here, we review the evidence that microRNAs act in vivo as regulators of aging pathways, with emphasis on Drosophila.
authors.affiliation: Institute of Molecular and Cell Biology, 61 Biopolis Dr., Singapore 138673, Singapore; Department of Biological Sciences, National University of Singapore, Singapore.
authors.forename: Devika
authors.initials: D
authors.lastname: Garg
authors.affiliation: Institute of Molecular and Cell Biology, 61 Biopolis Dr., Singapore 138673, Singapore; Department of Biological Sciences, National University of Singapore, Singapore. Electronic address: scohen@imcb.a-star.edu.sg.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Cohen
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D004330:Drosophila / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
keywords: Aging; Caenorhabditis elegans; Drosophila; Genetics; microRNA