title: Drug-induced liver injury: what was new in 2013?
abstract: BACKGROUND
  The year 2013 continued to highlight numerous aspects of drug-induced liver injury (DILI), with new information communicated via > 1500 publications. New reports of DILI were described and FDA warnings and alerts were issued for a number of products, emphasizing the risks related to hepatotoxicity.
  
  
  METHODS
  We provide a summary of the year's published reports of new causes of DILI, along with reviews and reports of established hepatotoxins, new and expanded DILI registries and the continuing emphasis placed on genetic and other risk factors. Several new analyses of data generated from the US DILI Network are included.
  
  
  CONCLUSIONS
  The clinical usefulness of pharmacogenetic testing remains to be determined; the number of patients who must be tested is large and the overall risk of DILI is quite small. The role that dose and hepatic metabolism play in causing idiosyncratic DILI was reviewed; daily doses > 50 - 100 mg of medications with high lipophilicity appear to be most predictive of severe DILI, but not in all cases. Restricting access to paracetamol in certain parts of the UK continues to demonstrate a successful reduction in the number of acute liver failure cases and patients listed for liver transplant.
authors.affiliation: Georgetown University Hospital, Department of Medicine, Division of Gastroenterology, Hepatology Section , 3800 Reservoir Road, NW, Washington, DC 20007 , USA lewisjh@gunet.georgetown.edu.
authors.forename: Walid M
authors.initials: WM
authors.lastname: Chalhoub
authors.forename: Kayla D
authors.initials: KD
authors.lastname: Sliman
authors.forename: Meera
authors.initials: M
authors.lastname: Arumuganathan
authors.forename: James H
authors.initials: JH
authors.lastname: Lewis
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology* / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology*; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D010597:Pharmacogenetics; D012307:Risk Factors
chemical_list: D000082:Acetaminophen
keywords: drug-induced liver injury; hepatotoxicity; pharmacogenomics