title: Potential benefits of therapeutic use of β2-adrenergic receptor agonists in neuroprotection and Parkinsonμs disease.
abstract: The β2-adrenergic receptor (β2AR) is a seven-transmembrane (7TM) G-protein coupled receptor that is expressed on cells of the pulmonary, cardiac, skeletal muscle, and immune systems. Previous work has shown that stimulation of this receptor on immune cells has profound effects on the regulatory activity of both adaptive and innate immune cells. This review examines the functional dichotomy associated with stimulation of β2AR and microglial cells. As well, recent studies targeting these receptors with long-acting agonists are considered with respect to their therapeutic potential in management of Parkinsonμs disease.
authors.affiliation: Theralogics, Inc., 1829 E. Franklin Street, Chapel Hill, NC 27514-5861, USA.
authors.forename: Lynda
authors.identifier: 0000-0002-6186-6460
authors.initials: L
authors.lastname: Peterson
authors.affiliation: School of Dentistry, University of Alberta, 7020 Katz Group Centre, Edmonton, AB, Canada T6G 2R3.
authors.forename: Kathleen P
authors.initials: KP
authors.lastname: Ismond
authors.affiliation: School of Dentistry, University of Alberta, 7020 Katz Group Centre, Edmonton, AB, Canada T6G 2R3.
authors.forename: Elisha
authors.identifier: 0000-0002-4385-5768
authors.initials: E
authors.lastname: Chapman
authors.affiliation: School of Dentistry, University of Alberta, 7020 Katz Group Centre, Edmonton, AB, Canada T6G 2R3 ; North Carolina Oral Health Institute, School of Dentistry, The University of North Carolina at Chapel Hill, Manning Dr. & Columbia Street, Campus Box 7450, Chapel Hill, NC 27599-7450, USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: Flood
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D006801:Humans; D007107:Immune System / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism*; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D018696:Neuroprotective Agents; D018343:Receptors, Adrenergic, beta-2
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