title: Interactions between intercellular adhesion molecule-5 positive elements and their surroundings in the rodent visual cortex.
abstract: The telencephalon-associated intercellular adhesion molecule 5 (Telencephalin; ICAM-5) regulates dendritic maturation, a process dependent on extracellular proteases in the developing brain. Using transmission electron microscopy, we have reported previously that ICAM-5 is localized primarily in dendritic protrusions during a period of robust synaptogenesis (P14 in mouse visual cortex). As dendritic protrusions mature (P28), ICAM-5 immuno-reactivity shifts from dendritic protrusions into dendritic shafts. ICAM-5 immuno-reactivity does not shift in animals lacking the matrix metalloproteinase-9 (MMP-9), a protease shown to regulate ICAM-5 cleavage. Cleaved ICAM-5 (soluble fraction; sICAM-5) has been shown to bind to a number of receptors located in neighboring structures, resulting in a variety of downstream signaling events, including enhanced neurotransmission. Here, we investigated the potential MMP-regulated ICAM-5 signaling by examining the relationship between ICAM-5 immuno-positive elements and the structures that directly neighbor them.
authors.affiliation: Neurobiology & Anatomy; University of Rochester; Rochester, NY USA.
authors.forename: Emily A
authors.initials: EA
authors.lastname: Kelly
authors.affiliation: Neurobiology & Anatomy; University of Rochester; Rochester, NY USA.
authors.forename: Marie-Ève
authors.initials: MÈ
authors.lastname: Tremblay
authors.affiliation: Department of Bioscience; University of Helsinki; Helsinki, Finland.
authors.forename: Carl G
authors.initials: CG
authors.lastname: Gahmberg
authors.affiliation: Neuroscience Center; University of Helsinki; Helsinki, Finland.
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.affiliation: Neurobiology & Anatomy; University of Rochester; Rochester, NY USA.
authors.forename: Ania K
authors.initials: AK
authors.lastname: Majewska
keywords: ICAM-5; Telencephalin; electron microscopy; mouse; ultrastructural; visual cortex
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