title: Touch spray mass spectrometry for in situ analysis of complex samples.
abstract: Touch spray, a spray-based ambient in situ ionization method, uses a small probe, e.g. a teasing needle to pick up sample and the application of voltage and solvent to cause field-induced droplet emission. Compounds extracted from the microsample are incorporated into the sprayed micro droplets. Performance tests include disease state of tissue, microorganism identification, and therapeutic drug quantitation. Chemical derivatization is performed simultaneously with ionization.
authors.affiliation: Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, IN, USA. cooks@purdue.edu.
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Kerian
authors.forename: Alan K
authors.initials: AK
authors.lastname: Jarmusch
authors.forename: R Graham
authors.initials: RG
authors.lastname: Cooks
mesh_terms: D016573:Agrochemicals / Q000032:analysis; D000818:Animals; D001419:Bacteria / Q000302:isolation & purification; D005506:Food Contamination / Q000032:analysis; D006801:Humans; D013287:Illicit Drugs / Q000302:isolation & purification; D008055:Lipids / Q000032:analysis; D008297:Male; D013058:Mass Spectrometry / Q000379:methods*; D051379:Mice; D011471:Prostatic Neoplasms / Q000175:diagnosis
chemical_list: D016573:Agrochemicals; D013287:Illicit Drugs; D008055:Lipids
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