title: Septic arthritis of the hip in a Cambodian child caused by multidrug-resistant Salmonella enterica serovar Typhi with intermediate susceptibility to ciprofloxacin treated with ceftriaxone and azithromycin.
abstract: Septic arthritis is a rare complication of typhoid fever. A 12-year-old boy without pre-existing disease attended a paediatric hospital in Cambodia with fever and left hip pain. A hip synovial fluid aspirate grew multidrug-resistant Salmonella enterica ser. Typhi with intermediate susceptibility to ciprofloxacin. Arthrotomy, 2 weeks of intravenous ceftriaxone and 4 weeks of oral azithromycin led to resolution of symptoms. The optimum management of septic arthritis in drug-resistant typhoid is undefined.
authors.forename: J M
authors.initials: JM
authors.lastname: Pocock
authors.forename: P A
authors.initials: PA
authors.lastname: Khun
authors.forename: C E
authors.initials: CE
authors.lastname: Moore
authors.forename: S
authors.initials: S
authors.lastname: Vuthy
authors.forename: N
authors.initials: N
authors.lastname: Stoesser
authors.forename: C M
authors.initials: CM
authors.lastname: Parry
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001170:Arthritis, Infectious / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D017963:Azithromycin / Q000627:therapeutic use*; D002160:Cambodia; D002443:Ceftriaxone / Q000627:therapeutic use*; D002648:Child; D003646:Debridement; D024901:Drug Resistance, Multiple, Bacterial; D006621:Hip Joint / Q000473:pathology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D012485:Salmonella typhi / Q000187:drug effects / Q000302:isolation & purification*; D013582:Synovial Fluid / Q000382:microbiology; D016896:Treatment Outcome; D014435:Typhoid Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D017963:Azithromycin
keywords: Azithromycin,; Cambodia; Ceftriaxone,; Child,; Hip,; Paediatric,; Salmonella typhi,; Septic arthritis,