title: Apoptosis-inducing effects of Melissa officinalis L. essential oil in glioblastoma multiforme cells.
abstract: Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and induced apoptosis of GBM cells as demonstrated by DNA fragmentation and caspase-3 activation. Antioxidant prevented citral-induced death, indicating its dependence on the production of reactive oxygen species. Citral downmodulated the activity and inhibited the expression of multidrug resistance associated protein 1 (MRP1). These results show that EO, through its major component, citral, may be of potential interest for the treatment of GBM.
authors.affiliation: Laboratório de Imunologia Celular, Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, Rio de Janeiro, RJ, Brazil,1.
authors.forename: Rafaela Muniz de
authors.initials: RM
authors.lastname: Queiroz
authors.forename: Christina Maeda
authors.initials: CM
authors.lastname: Takiya
authors.forename: Lívia Paes Tavares Pacheco
authors.initials: LP
authors.lastname: Guimarães
authors.forename: Gleice da Graça
authors.initials: Gda G
authors.lastname: Rocha
authors.forename: Daniela Sales
authors.initials: DS
authors.lastname: Alviano
authors.forename: Arie Fitzgerald
authors.initials: AF
authors.lastname: Blank
authors.forename: Celuta Sales
authors.initials: CS
authors.lastname: Alviano
authors.forename: Cerli Rocha
authors.initials: CR
authors.lastname: Gattass
mesh_terms: D000080462:Acyclic Monoterpenes; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000096:biosynthesis; D045744:Cell Line, Tumor; D053938:DNA Fragmentation / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D005909:Glioblastoma / Q000188:drug therapy; D006801:Humans; D031334:Melissa / Q000737:chemistry*; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000096:biosynthesis; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000080462:Acyclic Monoterpenes; D053148:Caspase 3; D039821:Monoterpenes; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009822:Oils, Volatile; D017382:Reactive Oxygen Species; C007076:citral; C421109:multidrug resistance-associated protein 1
keywords: Chemotherapy; Citral; Gliobastoma multiforme; Melissa officinali essential oil