title: Total synthesis of (+)-kopsihainanine A.
abstract: Total synthesis of (+)-kopsihainanine A was accomplished on the basis of (i) Stoltz's enantioselective decarboxylative asymmetric allylation and (ii) the proposed biogenetic pathway from the related alkaloid, kopsihainanine B. In addition, HPLC analysis of the synthetic (+)-kopsihainanine A confirmed its ee to be 99% with [α] = 25.35.
authors.affiliation: Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. mukai@p.kanazawa-u.ac.jp.
authors.forename: Masaya
authors.initials: M
authors.lastname: Mizutani
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yasuda
authors.forename: Chisato
authors.initials: C
authors.lastname: Mukai
mesh_terms: D060326:Chemistry Techniques, Synthetic; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; C562138:kopsihainanine A