title: A new ratio for protocol categorization.
abstract: The present review describes and validates a new ratio "S" created for matching predictability and balance between TP and TN. Validity of S was studied in a three-step process as follows: (i) S was applied to the data of a past study predicting cardiac output response to fluid bolus from response to passive leg raise (PLR); (ii) S was comparatively analyzed with traditional ratios by modeling different 2 ∗ 2 contingency tables in 1000 hypothetical patients; (iii) precision of S was compared with other ratios by computing random fluctuations in the same patients. In comparison to other ratios, S performs better in predicting the cardiac response to fluid bolus and supports more directly the clinical conclusions. When the proportion of false responses is high, S is close to the coefficient correlation (CC). When the proportion of true responses is high, S is the unique ratio that identifies the categorization that balances the proportion of TP and TN. The precision of S is close to that of CC. In conclusion, S should be considered for creating categories from quantitative variables; especially when matching predictability with balance between TP and TN is a concern.
authors.affiliation: CERIC, Clinique Ambroise Paré, 27 boulevard Victor Hugo, 92200 Neuilly-sur-Seine, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Squara
mesh_terms: D000465:Algorithms; D002302:Cardiac Output; D003198:Computer Simulation; D018849:Controlled Clinical Trials as Topic; D006321:Heart / Q000502:physiology*; D006801:Humans; D007866:Leg / Q000502:physiology; D055370:Lung Injury / Q000150:complications / Q000503:physiopathology; D016017:Odds Ratio; D012372:ROC Curve; D015203:Reproducibility of Results; D012107:Research Design; D012306:Risk; D012680:Sensitivity and Specificity; D012769:Shock / Q000150:complications / Q000503:physiopathology
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