title: Hepatoprotective activity of Tephrosia purpurea against arsenic induced toxicity in rats.
abstract: OBJECTIVE
  The present study was conducted to evaluate the hepatoprotective activity of Tephrosia purpurea (TP) against sodium arsenite (NaAsO2) induced sub-acute toxicity in rats.
  
  
  METHODS
  Twenty four wistar albino rats of either sex were randomly divided into three groups. Group II and III were orally administered with sodium arsenite (10 mg/kg) daily in drinking water for 28 days. Additionally Group III was orally treated with hydro-alcoholic extract of Tephrosia purpurea (TP) @ 500 mg/kg daily for the same time period, whereas only deionized water was given to Group I (control). Serum biomarker levels, oxidative stress parameters and arsenic concentration were assessed in liver. Histopathology was also conducted.
  
  
  RESULTS
  It has been seen that TPE (500 mg/kg) significantly (P < 0.01) reduced serum ALT, AST, ALP activity and increased total protein and reduced necrosis and inflammation in liver of group III compared to group II. A significantly (P < 0.01) higher LPO and lower GSH levels without change in SOD activity in liver was also observed in group II compared to group III, though there was no significant difference in arsenic accumulation between them. The plant extract also protects the animals of group III from significant (P < 0.01) reduction in body weight.
  
  
  CONCLUSIONS
  Our study shows that supplementation of Tephrosia purpurea extract (500 mg/kg) could ameliorate the hepatotoxic action of arsenic.
authors.affiliation: Departments of Veterinary Pharmacology and Toxicology, College of Veterinary Sciences and AH, Birsa Agricultural University, Ranchi, India.
authors.forename: Ravuri Halley
authors.initials: RH
authors.lastname: Gora
authors.affiliation: Departments of Veterinary Pharmacology and Toxicology, College of Veterinary Sciences and AH, Birsa Agricultural University, Ranchi, India.
authors.forename: Sushma Lalita
authors.initials: SL
authors.lastname: Baxla
authors.affiliation: Department of Veterinary Public Health, I.V.R.I. Izatnagar, Bareilly, India.
authors.forename: Priscilla
authors.initials: P
authors.lastname: Kerketta
authors.affiliation: Department of Veterinary Microbiology, Birsa Agricultural University, Ranchi, India.
authors.forename: Subhasree
authors.initials: S
authors.lastname: Patnaik
authors.affiliation: Departments of Veterinary Pharmacology and Toxicology, College of Veterinary Sciences and AH, Birsa Agricultural University, Ranchi, India.
authors.forename: Birendra Kumar
authors.initials: BK
authors.lastname: Roy
mesh_terms: D000818:Animals; D018053:Arsenites / Q000493:pharmacokinetics / Q000633:toxicity*; D015415:Biomarkers / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D017208:Rats, Wistar; D017670:Sodium Compounds / Q000493:pharmacokinetics / Q000633:toxicity*; D031304:Tephrosia / Q000737:chemistry*; D059551:Toxicity Tests, Subacute; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D018053:Arsenites; D015415:Biomarkers; D010936:Plant Extracts; D017670:Sodium Compounds; D014874:Water Pollutants, Chemical; C017947:sodium arsenite
keywords: Arsenic; Tephrosia purpurea; hepatotoxicity; rats; sub-acute toxicity
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