title: The synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin.
abstract: Oleanolic and ursolic acids are natural triterpenic compounds with pentacyclic cholesterol-like structures which gives them very low water solubility, a significant disadvantage in terms of bioavailability. We previously reported the synthesis of inclusion complexes between these acids and cyclodextrins, as well as their in vivo evaluation on chemically induced skin cancer experimental models. In this study the synergistic activity of the acid mixture included inside hydroxypropyl-gamma-cyclodextrin (HPGCD) was monitored using in vitro tests and in vivo skin cancer models. The coefficient of drug interaction (CDI) was used to characterize the interactions as synergism, additivity or antagonism. Our results revealed an increased antitumor activity for the mixture of the two triterpenic acids, both single and in complex with cyclodextrin, thus proving their complementary biologic activities.
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. codrutasoica@umft.ro.
authors.forename: Codruţa
authors.initials: C
authors.lastname: Soica
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. camelia.oprean@umft.ro.
authors.forename: Camelia
authors.initials: C
authors.lastname: Oprean
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. fborcan@yahoo.com.
authors.forename: Florin
authors.initials: F
authors.lastname: Borcan
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. cadehelean@umft.ro.
authors.forename: Corina
authors.initials: C
authors.lastname: Danciu
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. trandafirescu.cristina@umft.ro.
authors.forename: Cristina
authors.initials: C
authors.lastname: Trandafirescu
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. dorinacoricovac@umft.ro.
authors.forename: Dorina
authors.initials: D
authors.lastname: Coricovac
authors.affiliation: Faculty of Medicine, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. zcrainiceanu@gmail.com.
authors.forename: Zorin
authors.initials: Z
authors.lastname: Crăiniceanu
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. cadehelean@umft.ro.
authors.forename: Cristina Adriana
authors.initials: CA
authors.lastname: Dehelean
authors.affiliation: Department of Clinical Laboratory and Sanitary Chemistry, "Vasile Goldis" University, 1 Feleacului Str., Arad 310396, Romania. anaionescuro@yahoo.com.
authors.forename: Melania
authors.initials: M
authors.lastname: Munteanu
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008545:Melanoma / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D009828:Oleanolic Acid / Q000493:pharmacokinetics / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D012995:Solubility; D014315:Triterpenes / Q000493:pharmacokinetics / Q000494:pharmacology*; D014466:Ultraviolet Rays; D047408:gamma-Cyclodextrins / Q000737:chemistry*; D000097245:Ursolic Acid
chemical_list: D015127:9,10-Dimethyl-1,2-benzanthracene; D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D009828:Oleanolic Acid; D014315:Triterpenes; D047408:gamma-Cyclodextrins; D000097245:Ursolic Acid; C479659:hydroxypropyl-gamma-cyclodextrin
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