title: Comprehensive analysis of systemically disseminated ST8/non-USA300 type community-acquired methicillin-resistant Staphylococcus aureus infection.
abstract: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is genetically heterogeneous and various genotypes are spreading worldwide. We herein report a case of systematically disseminated Japan-intrinsic CA-MRSA infection that was successfully treated. A genetically identical single strain was isolated from a total of 11 different parts of the patient's body, and the pathogen was found to be multilocus sequence type 8, staphylococcal cassette chromosome mec IV, coagulase type III and negative for both Panton-Valentine leukocidin and arginine catabolic mobile element. The epidemiology and pathogenicity of the Japan-intrinsic CA-MRSA strain remain unknown, and further investigation of this life-threatening organism is warranted.
authors.affiliation: Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
authors.forename: Hideharu
authors.initials: H
authors.lastname: Hagiya
authors.forename: Junzo
authors.initials: J
authors.lastname: Hisatsune
authors.forename: Taro
authors.initials: T
authors.lastname: Kojima
authors.forename: Sumiko
authors.initials: S
authors.lastname: Shiota
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Naito
authors.forename: Shingo
authors.initials: S
authors.lastname: Hagioka
authors.forename: Naoki
authors.initials: N
authors.lastname: Morimoto
authors.forename: Fumio
authors.initials: F
authors.lastname: Otsuka
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Sugai
mesh_terms: D000368:Aged; D001426:Bacterial Proteins / Q000235:genetics; D001431:Bacteriological Techniques; D017714:Community-Acquired Infections / Q000235:genetics / Q000382:microbiology*; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D055624:Methicillin-Resistant Staphylococcus aureus; D058885:Multilocus Sequence Typing; D016133:Polymerase Chain Reaction; D013203:Staphylococcal Infections / Q000235:genetics / Q000382:microbiology*
chemical_list: D001426:Bacterial Proteins