title: Nonalcoholic fatty liver disease and hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) incidence is increasing worldwide in recent years. Most HCC cases develop in the presence of advanced chronic liver disease related to chronic hepatitis C virus (HCV) infection, chronic hepatitis B (HBV) infection, and alcohol abuse. Approximately 15-50% of HCC cases are classified as idiopathic, suggesting that other risk factors are responsible for its rising incidence. Recent studies suggest that nonalcoholic fatty liver disease (NAFLD) can be associated with these "idiopathic" cases. NAFLD progresses slowly and can develop into liver cirrhosis, liver failure, and HCC. In the last few years, NAFLD has received more attention because of its high prevalence worldwide.
authors.affiliation: São Paulo Clínicas Liver Cancer Group, Hospital das Clínicas, Instituto do Câncer do Estado de São Paulo, Department of Gastroenterology, University of São Paulo School of Medicine, Avenida Dr. Enéas de Carvalho Aguiar No. 255, Instituto Central No. 9159, 05403-000 Sao Paulo, SP, Brazil.
authors.forename: Luciana
authors.initials: L
authors.lastname: Kikuchi
authors.affiliation: São Paulo Clínicas Liver Cancer Group, Hospital das Clínicas, Instituto do Câncer do Estado de São Paulo, Department of Gastroenterology, University of São Paulo School of Medicine, Avenida Dr. Enéas de Carvalho Aguiar No. 255, Instituto Central No. 9159, 05403-000 Sao Paulo, SP, Brazil.
authors.forename: Cláudia P
authors.initials: CP
authors.lastname: Oliveira
authors.affiliation: São Paulo Clínicas Liver Cancer Group, Hospital das Clínicas, Instituto do Câncer do Estado de São Paulo, Department of Gastroenterology, University of São Paulo School of Medicine, Avenida Dr. Enéas de Carvalho Aguiar No. 255, Instituto Central No. 9159, 05403-000 Sao Paulo, SP, Brazil.
authors.forename: Flair J
authors.initials: FJ
authors.lastname: Carrilho
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology*; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications*; D012307:Risk Factors
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