title: [Identification of genetic polymorphisms associated with overweight in athletes of winter sports].
abstract: The identification of polymorphisms rs9939609 gene FTO, Trp64Arg ADRB3 and gene -866G> A UCP2 gene using multiplex allele-specific PCR hybridization-fluorescence detection in real time has been carried out in highly skilled athletes under the age of 30 years engaged in biathlon (n = 25) and bobsleigh (n = 28). The data on the frequency of allele risk of obesity has been obtained. The study of polymorphism rs9939609 of the FTO gene in biathletes found that 30% of them are carriers of the risk allele of obesity (A). Among the bobsledder the frequency of allele A is slightly higher than in European populations and is 55.4%. The study of gene polymorphism Trp64Arg ADRB3 shored that the frequency of risk allele of obesity 64Arg in biathletes (14%) was slightly higher than in the European population and biathletes (5.4%). The results of the identification of polymorphism -866G> A gene UCP2 in biathletes and bobsledders, found the incidence of obesity risk allele, respectively, 52 and 58.7%.
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Sorokina
authors.forename: T N
authors.initials: TN
authors.lastname: Solntseva
authors.forename: R M
authors.initials: RM
authors.lastname: Radzhabkadiev
authors.forename: A S
authors.initials: AS
authors.lastname: Samoĭlov
mesh_terms: D000293:Adolescent; D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D003627:Data Interpretation, Statistical; D005787:Gene Frequency; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D024101:Mitochondrial Proteins / Q000235:genetics*; D050177:Overweight / Q000235:genetics*; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics*; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D012306:Risk; D038161:Snow Sports / Q000502:physiology*; D000071246:Uncoupling Protein 2; D055815:Young Adult
chemical_list: C568534:ADRB3 protein, human; D007473:Ion Channels; D024101:Mitochondrial Proteins; D011506:Proteins; D022702:Receptors, Adrenergic, beta-3; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human