title: Therapeutic strategies for treating osteolytic bone metastases.
abstract: The recent progress in oncologic management of patients with localized cancer or metastatic disease has permitted a significant improvement in life expectancy. Nevertheless, bone metastases and their consequent skeletal-related events (SREs) are still associated with unfavorable prognosis and greatly affect quality of life. Global management of these bone metastases includes traditional local approaches (surgery, radiotherapy, etc.) and systemic administration of chemotherapeutic agents. This review focuses on treatments specific for bone metastases and, in particular, on inhibitors of bone resorption that are effective for preventing and delaying the development of SREs.
authors.affiliation: INSERM U791, Université de Nantes, Faculté de Chirurgie Dentaire, 44042 Nantes, France. Electronic address: elise.verron@univ-nantes.fr.
authors.forename: Elise
authors.initials: E
authors.lastname: Verron
authors.affiliation: Univ Nice Sophia Antipolis, CNRS, iBV, UMR7277, UFR Médecine, 06107 Nice Cedex 2, France.
authors.forename: Heidy
authors.initials: H
authors.lastname: Schmid-Antomarchi
authors.affiliation: Hopital Pitié-Salpétrière, Service de Chirurgie, 75 651 Paris Cedex, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Pascal-Mousselard
authors.affiliation: Univ Nice Sophia Antipolis, CNRS, iBV, UMR7277, UFR Médecine, 06107 Nice Cedex 2, France.
authors.forename: Annie
authors.initials: A
authors.lastname: Schmid-Alliana
authors.affiliation: Univ Nice Sophia Antipolis, CNRS, iBV, UMR7277, UFR Médecine, 06107 Nice Cedex 2, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Scimeca
authors.affiliation: INSERM U791, Université de Nantes, Faculté de Chirurgie Dentaire, 44042 Nantes, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Bouler
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D006801:Humans; D008017:Life Expectancy; D010014:Osteolysis / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D011788:Quality of Life
chemical_list: D000970:Antineoplastic Agents; D050071:Bone Density Conservation Agents