title: New cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum Hance.
abstract: Two new dimeric diarylheptanoids, named Alpinin C (1) and D (2), a new natural product of diarylheptanoid (3) along with three known diarylheptanoids (4-6) were isolated from the rhizomes of Alpinia officinarum Hance. Their structures were elucidated based on extensive spectroscopic analyses (1D and 2D NMR, HRTOFMS, IR). The isolated compounds were evaluated for their cytotoxicity against human tumor cell lines HepG2, MCF-7, T98G and B16-F10. Compound 1 showed selective cytotoxicity against cell lines of MCF-7 and T98G, while compound 6 showed significant cytotoxicity to the all tested tumor cell lines with IC50 in the range from 8.46 to 22.68 μmol/L.
authors.affiliation: Hubei Key Laboratory of Resource Science and Chemistry in Chinese Medicine, Hubei university of Chinese Medicine, Wuhan 430061, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Hubei Key Laboratory of Resource Science and Chemistry in Chinese Medicine, Hubei university of Chinese Medicine, Wuhan 430061, China.
authors.forename: Yan-Wen
authors.initials: YW
authors.lastname: Liu
authors.affiliation: Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.
authors.forename: Fu-Qin
authors.initials: FQ
authors.lastname: Guan
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: jyliang08@126.com.
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Liang
mesh_terms: D032429:Alpinia / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D036381:Diarylheptanoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry
chemical_list: C000596883:Alpinin C; C000596884:Alpinin D; D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids; D010936:Plant Extracts
keywords: Alpinia officinarum Hance; Cytotoxicity; Diarylheptanoids