title: Homonymous hemianopia due to Erdheim-Chester disease.
abstract: Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis typically affecting multiple organ systems. We report 2 patients who presented with homonymous hemianopia and were ultimately diagnosed with biopsy-confirmed ECD. We review the spectrum of ECD and its treatment as well as histopathological and immunohistochemical differentiation from other histiocytic disorders.
authors.affiliation: Department of Neuro-Ophthalmology (WLH, JF), Casey Eye Institute, Oregon Health & Science University, Portland, Oregon; Departments of Neurology (WLH) and Ophthalmology (WLH, JF), Oregon Health & Science University, Portland, Oregon; Arab Organization for Industrialization Hospital (AN), Cairo, Egypt; Department of Neuropathology (MRG), Oregon Health & Science University, Portland, Oregon; University of Pennsylvania School of Medicine (SJM), Philadelphia, Pennsylvania; Department of Radiology, Ophthalmology, and Otolaryngology (JLW), Oregon Health & Science University, Portland, Oregon; Department of Pathology (SKM, MTC), Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania; Department of Neuro-Ophthalmology (MLM), Wills Eye Institute, Philadelphia, Pennsylvania; and Departments of Neurology (MLM) and Ophthalmology (MLM), Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania.
authors.forename: William L
authors.initials: WL
authors.lastname: Hills
authors.forename: Ahmad H
authors.initials: AH
authors.lastname: Nassef
authors.forename: Marjorie R
authors.initials: MR
authors.lastname: Grafe
authors.forename: Jane L
authors.initials: JL
authors.lastname: Weissman
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Moster
authors.forename: Julie
authors.initials: J
authors.lastname: Falardeau
authors.forename: Stacey K
authors.initials: SK
authors.lastname: Mardekian
authors.forename: Mark T
authors.initials: MT
authors.lastname: Curtis
authors.forename: Mark L
authors.initials: ML
authors.lastname: Moster
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D031249:Erdheim-Chester Disease / Q000150:complications*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005260:Female; D006423:Hemianopsia / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014794:Visual Fields / Q000502:physiology; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D016326:Extracellular Matrix Proteins; D018960:Hyaluronan Receptors; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C098946:hyaluronan-mediated motility receptor