title: Contrasting changes in extracellular dopamine and glutamate along the rostrocaudal axis of the anterior cingulate cortex of the rat following an acute d-amphetamine or dopamine challenge.
abstract: There is evidence for functional specificity of subregions along the rostrocaudal axis of the anterior cingulate cortex (ACC). The subregion-specific distribution of dopaminergic afferents and glutamatergic efferents along the ACC make these obvious candidates for coding such regional responses. We investigated this possibility using microdialysis in freely-moving rats to compare changes in extracellular dopamine and glutamate in the rostral ('rACC': Cg1 and Cg3 (prelimbic area)) and caudal ('cACC': Cg1 and Cg2) ACC induced by systemic or local administration of d-amphetamine. Systemic administration of d-amphetamine (3 mg/kg, i.p.) caused a transient increase in extracellular dopamine in the rACC, but an apparent increase in the cACC of the same animals was less clearly defined. Local infusion of d-amphetamine increased dopamine efflux in the rACC, only. Glutamate efflux in the rACC was increased by local infusion of dopamine (5-50 μM), which had negligible effect in the cACC, but only systemic administration of d-amphetamine increased glutamate efflux and only in the cACC. The asymmetry in the neurochemical responses within the rACC and cACC, to the same experimental challenges, could help explain why different subregions are recruited in the response to specific environmental and somatosensory stimuli and should be taken into account when studying the regulation of neurotransmission in the ACC. This article is part of the Special Issue entitled 'CNS Stimulants'.
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Ash
authors.affiliation: RenaSci Ltd., Pennyfoot Street, Nottingham NG1 1GF, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Heal
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: c.stanford@ucl.ac.uk.
authors.forename: S
authors.initials: S
authors.lastname: Clare Stanford
mesh_terms: D000661:Amphetamine / Q000008:administration & dosage*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D004298:Dopamine / Q000008:administration & dosage* / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D011897:Random Allocation; D017207:Rats, Sprague-Dawley
chemical_list: D000697:Central Nervous System Stimulants; D018698:Glutamic Acid; D000661:Amphetamine; D004298:Dopamine
keywords: Anterior cingulate cortex; Dopamine; GLT-1; Glutamate; Microdialysis; d-Amphetamine
references.citation: Trends Neurosci. 1991 Jan;14(1):21-7
references.pmid: 1709528
references.citation: J Comp Neurol. 2009 Feb 1;512(4):529-55
references.pmid: 19025979
references.citation: Hum Psychopharmacol. 2003 Jun;18(4):291-9
references.pmid: 12766934
references.citation: J Biol Chem. 2009 Jan 30;284(5):2978-2989
references.pmid: 19047053
references.citation: Brain Res. 1991 Apr 26;547(1):37-52
references.pmid: 1907216
references.citation: Biol Psychiatry. 2003 Jan 1;53(1):65-74
references.pmid: 12513946
references.citation: J Neurochem. 2000 Oct;75(4):1634-44
references.pmid: 10987845
references.citation: Br J Pharmacol. 2003 Aug;139(8):1441-8
references.pmid: 12922931
references.citation: Biol Psychiatry. 1999 Jun 15;45(12):1542-52
references.pmid: 10376114
references.citation: Neuroscience. 1987 Sep;22(3):849-62
references.pmid: 3683852
references.citation: Neuroimage. 2007 Aug 15;37(2):579-88
references.pmid: 17604651
references.citation: J Neurochem. 1995 Dec;65(6):2644-51
references.pmid: 7595562
references.citation: Neurosci Biobehav Rev. 2003 Oct;27(6):555-79
references.pmid: 14599436
references.citation: Mol Pharmacol. 1995 Feb;47(2):368-73
references.pmid: 7870046
references.citation: Psychopharmacology (Berl). 2003 Feb;165(4):359-69
references.pmid: 12491026
references.citation: J Neurochem. 1998 Oct;71(4):1443-9
references.pmid: 9751176
references.citation: J Neurosci. 1997 Aug 1;17(15):5738-46
references.pmid: 9221772
references.citation: Synapse. 2004 Jul;53(1):44-52
references.pmid: 15150740
references.citation: Brain Res. 1991 Nov 29;565(2):290-300
references.pmid: 1726843
references.citation: Neuropsychopharmacology. 2004 Jan;29(1):72-80
references.pmid: 12968132
references.citation: Neuroscience. 1985 Aug;15(4):983-98
references.pmid: 2864660
references.citation: Brain Res. 1978 Feb 17;142(1):1-24
references.pmid: 626911
references.citation: Biol Psychiatry. 2008 Nov 1;64(9):758-65
references.pmid: 18639238
references.citation: Neurosci Biobehav Rev. 2005;29(6):949-62
references.pmid: 15963566
references.citation: Exp Brain Res. 2000 Jul;133(1):55-65
references.pmid: 10933210
references.citation: Neuroscience. 1984 Feb;11(2):425-35
references.pmid: 6201780
references.citation: J Neurochem. 1995 Jul;65(1):201-7
references.pmid: 7790861
references.citation: J Neurosci Methods. 1995 Mar;57(1):93-9
references.pmid: 7791370
references.citation: J Neurosci Methods. 1994 Sep;54(1):75-82
references.pmid: 7815821
references.citation: Glia. 2006 Nov 15;54(7):700-15
references.pmid: 17006898
references.citation: Psychopharmacology (Berl). 2007 Aug;193(3):375-90
references.pmid: 17468969
references.citation: Biol Psychiatry. 2008 May 1;63(9):821-31
references.pmid: 18155183
references.citation: Brain Res Bull. 1979 Nov-Dec;4(6):849-57
references.pmid: 393366
references.citation: Pharmacol Biochem Behav. 1974 Mar-Apr;2(2):249-55
references.pmid: 4857295
references.citation: Mol Cell Neurosci. 2001 Aug;18(2):197-209
references.pmid: 11520180
references.citation: Prog Neurobiol. 2004 Sep;74(1):1-58
references.pmid: 15381316
references.citation: Nat Rev Neurosci. 2005 Jul;6(7):533-44
references.pmid: 15995724
references.citation: J Neurochem. 2003 Apr;85(1):23-33
references.pmid: 12641724
references.citation: Brain Res Bull. 1982 Jul-Dec;9(1-6):321-53
references.pmid: 6816390
references.citation: Brain Res. 2002 May 17;936(1-2):58-67
references.pmid: 11988230
references.citation: Neurochem Res. 1998 Sep;23(9):1153-8
references.pmid: 9712184
references.citation: Pharmacol Biochem Behav. 2008 Aug;90(2):135-47
references.pmid: 17939932
references.citation: J Neurochem. 2001 Oct;79(1):130-42
references.pmid: 11595765
references.citation: Neurosci Lett. 2004 Sep 9;367(3):349-54
references.pmid: 15337264
references.citation: Neuroscience. 1998 May;84(2):413-29
references.pmid: 9539213
references.citation: Synapse. 1997 Nov;27(3):242-61
references.pmid: 9329159
references.citation: Neurosci Lett. 1995 Dec 8;201(2):175-8
references.pmid: 8848246
references.citation: Neuropharmacology. 2008 Oct;55(5):755-62
references.pmid: 18602932
references.citation: J Psychopharmacol. 2009 Jun;23(4):410-8
references.pmid: 18635707
references.citation: Neuroscience. 2005;133(1):193-207
references.pmid: 15893643
references.citation: J Neurosci Methods. 2001 Aug 15;109(1):53-8
references.pmid: 11489300
references.citation: Synapse. 1997 Oct;27(2):95-105
references.pmid: 9266771
references.citation: Trends Cogn Sci. 2000 Jun;4(6):215-222
references.pmid: 10827444
references.citation: J Neurosci. 2002 Oct 15;22(20):9134-41
references.pmid: 12388621
references.citation: Neurochem Int. 2008 Jan;52(1-2):142-54
references.pmid: 17669556
references.citation: Neurosci Lett. 2003 Oct 30;350(3):157-60
references.pmid: 14550918
references.citation: J Neural Transm (Vienna). 2009 Aug;116(8):941-52
references.pmid: 19475335
references.citation: Brain. 1995 Feb;118 ( Pt 1):279-306
references.pmid: 7895011
references.citation: J Neurosci. 1997 Nov 1;17(21):8498-505
references.pmid: 9334422
references.citation: Brain Struct Funct. 2007 Sep;212(2):149-79
references.pmid: 17717690
references.citation: J Comp Neurol. 2008 Jan 1;506(1):30-45
references.pmid: 17990270
references.citation: J Neural Transm (Vienna). 2005 Jan;112(1):121-5
references.pmid: 15599610
references.citation: Brain Res. 1996 Oct 21;737(1-2):221-30
references.pmid: 8930369
references.citation: Brain Res Bull. 1993;32(2):195-200
references.pmid: 8348345
references.citation: Behav Brain Res. 2003 Nov 30;146(1-2):3-17
references.pmid: 14643455
references.citation: Cereb Cortex. 2009 Apr;19(4):849-60
references.pmid: 18689859
references.citation: Biol Psychiatry. 2007 Nov 15;62(10):1191-4
references.pmid: 17707349
references.citation: J Pharmacol Exp Ther. 1999 Apr;289(1):14-23
references.pmid: 10086982
references.citation: Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8077-82
references.pmid: 11416168
references.citation: Brain Res. 1978 Feb 24;142(2):249-67
references.pmid: 24492
references.citation: J Comp Neurol. 1995 Aug 21;359(2):340-9
references.pmid: 7499533
references.citation: Cereb Cortex. 2008 Apr;18(4):796-805
references.pmid: 17652463
references.citation: J Neurosci. 1998 Apr 1;18(7):2697-708
references.pmid: 9502827
references.citation: J Neural Transm (Vienna). 2005 Jan;112(1):97-109
references.pmid: 15599608