title: Thyroid function and body weight: a community-based longitudinal study.
abstract: OBJECTIVE
  Body weight and overt thyroid dysfunction are associated. Cross-sectional population-based studies have repeatedly found that thyroid hormone levels, even within the normal reference range, might be associated with body weight. However, for longitudinal data, the association is less clear. Thus, we tested the association between serum thyrotropin (TSH) and body weight in a community-based sample of adult persons followed for 11 years.
  
  
  METHODS
  A random sample of 4,649 persons aged 18-65 years from a general population participated in the DanThyr study in 1997-8. We included 2,102 individuals who participated at 11-year follow-up, without current or former treatment for thyroid disease and with measurements of TSH and weight at both examinations. Multiple linear regression models were used, stratified by sex and adjusted for age, smoking status, and leisure time physical activity.
  
  
  RESULTS
  Baseline TSH concentration was not associated with change in weight (women, P = 0.17; men, P = 0.72), and baseline body mass index (BMI) was not associated with change in TSH (women, P = 0.21; men, P = 0.85). Change in serum TSH and change in weight were significantly associated in both sexes. Weight increased by 0.3 kg (95% confidence interval [CI] 0.1, 0.4, P = 0.005) in women and 0.8 kg (95% CI 0.1, 1.4, P = 0.02) in men for every one unit TSH (mU/L) increase.
  
  
  CONCLUSIONS
  TSH levels were not a determinant of future weight changes, and BMI was not a determinant for TSH changes, but an association between weight change and TSH change was present.
authors.affiliation: Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark; Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, Denmark.
authors.forename: Lena
authors.initials: L
authors.lastname: Bjergved
authors.affiliation: Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark; Faculty of Health Sciences, Copenhagen, Denmark; Faculty of Medicine, Aalborg University, Aalborg, Denmark.
authors.forename: Torben
authors.initials: T
authors.lastname: Jørgensen
authors.affiliation: Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, Denmark.
authors.forename: Hans
authors.initials: H
authors.lastname: Perrild
authors.affiliation: Faculty of Medicine, Aalborg University, Aalborg, Denmark; Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Laurberg
authors.affiliation: Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Anne
authors.initials: A
authors.lastname: Krejbjerg
authors.affiliation: Department of Gastroenterology, Slagelse Hospital, Slagelse, Denmark.
authors.forename: Lars
authors.initials: L
authors.lastname: Ovesen
authors.affiliation: Department of Nutrition, National Food Institute, Technical University of Denmark, Søborg, Denmark.
authors.forename: Lone Banke
authors.initials: LB
authors.lastname: Rasmussen
authors.affiliation: Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, Denmark.
authors.forename: Nils
authors.initials: N
authors.lastname: Knudsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001835:Body Weight / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood; D055815:Young Adult
chemical_list: D013972:Thyrotropin
references.citation: Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1067-73
references.pmid: 15657093
references.citation: Clin Endocrinol (Oxf). 2006 Feb;64(2):125-8
references.pmid: 16430708
references.citation: Clin Endocrinol (Oxf). 2011 Jun;74(6):769-75
references.pmid: 21521278
references.citation: J Clin Endocrinol Metab. 2005 Jul;90(7):4019-24
references.pmid: 15870128
references.citation: Obesity (Silver Spring). 2010 Apr;18(4):854-7
references.pmid: 19834461
references.citation: Endocrinology. 2010 Jul;151(7):3460-9
references.pmid: 20410193
references.citation: Thyroid. 2003 Nov;13(11):1069-78
references.pmid: 14651790
references.citation: Surg Obes Relat Dis. 2007 Nov-Dec;3(6):631-5; discussion 635-6
references.pmid: 18023816
references.citation: J Clin Endocrinol Metab. 2000 Jun;85(6):2299-303
references.pmid: 10852467
references.citation: J Biol Chem. 2000 Nov 17;275(46):36124-33
references.pmid: 10967095
references.citation: Exp Clin Endocrinol Diabetes. 2010 Apr;118(4):266-73
references.pmid: 19609846
references.citation: Thyroid. 2007 May;17(5):413-9
references.pmid: 17542671
references.citation: J Clin Endocrinol Metab. 2009 Dec;94(12):5023-7
references.pmid: 19846737
references.citation: Mol Cell Endocrinol. 2010 Mar 25;316(2):165-71
references.pmid: 19540303
references.citation: J Clin Endocrinol Metab. 1987 May;64(5):969-74
references.pmid: 3558731
references.citation: Eur Thyroid J. 2012 Oct;1(3):159-67
references.pmid: 24783015
references.citation: Eur J Endocrinol. 2006 Aug;155(2):219-28
references.pmid: 16868134
references.citation: J Clin Endocrinol Metab. 2012 Nov;97(11):4022-9
references.pmid: 22962423
references.citation: S Afr J Med Sci. 1967 Oct;32(3):70-82
references.pmid: 5582547
references.citation: BMJ. 2001 Nov 10;323(7321):1123-4
references.pmid: 11701584
references.citation: Arch Intern Med. 2008 Mar 24;168(6):587-92
references.pmid: 18362250
references.citation: Clin Endocrinol (Oxf). 2003 Jan;58(1):36-42
references.pmid: 12519410
references.citation: J Clin Endocrinol Metab. 2010 Dec;95(12):5412-8
references.pmid: 20843953
references.citation: J Clin Endocrinol Metab. 1990 Feb;70(2):453-60
references.pmid: 2105333
references.citation: Clin Endocrinol (Oxf). 2011 Jul;75(1):120-6
references.pmid: 21521277
references.citation: J Clin Endocrinol Metab. 2002 Oct;87(10):4747-53
references.pmid: 12364469
references.citation: Clin Endocrinol (Oxf). 2008 Oct;69(4):648-52
references.pmid: 18346211
references.citation: Eur J Endocrinol. 2000 Oct;143(4):485-91
references.pmid: 11022194
references.citation: J Clin Endocrinol Metab. 1997 Apr;82(4):1118-25
references.pmid: 9100583
references.citation: J Clin Endocrinol Metab. 1992 Aug;75(2):344-50
references.pmid: 1639933
references.citation: Arch Intern Med. 2008 Nov 10;168(20):2283-4
references.pmid: 19001207
references.citation: Cell Metab. 2013 Jul 2;18(1):29-42
references.pmid: 23770129
references.citation: Int J Obes (Lond). 2006 Jan;30(1):100-5
references.pmid: 16189501
references.citation: J Clin Endocrinol Metab. 2006 Aug;91(8):3088-91
references.pmid: 16684827
references.citation: Eur J Endocrinol. 2003 Oct;149(4):257-71
references.pmid: 14514340
references.citation: J Clin Endocrinol Metab. 1997 Mar;82(3):771-6
references.pmid: 9062480
references.citation: PLoS One. 2012;7(4):e34979
references.pmid: 22511976