title: Evaluation of human health risks posed by carcinogenic and non-carcinogenic multiple contaminants associated with consumption of fish from Taihu Lake, China.
abstract: The present study estimated the human daily intake and uptake of organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), and toxic trace elements [mercury (Hg), chromium (Cr), cadmium (Cd), and arsenic (As)] due to consumption of fish from Taihu Lake, China, and the associated potential health risks posed by these contaminants. The health risks posed by the contaminants were assessed using a risk quotient of the fish consumption rate to the maximum allowable fish consumption rate considering the contaminants for carcinogenic and non-carcinogenic effect endpoints. The results showed that fish consumption would not pose non-cancer risks. However, some species would cause a cancer risk. Relative risks of the contaminants were calculated to investigate the contaminant which posed the highest risk to humans. As a result, in view of the contaminants for carcinogenic effects, As was the contaminant which posed the highest risk to humans. However, when non-carcinogenic effects of the contaminants were considered, Hg posed the highest risk. The risk caused by PBDEs was negligible. The results demonstrated that traditional contaminants, such as As, Hg, DDTs (dichlorodiphenyltrichloroethane and its metabolites), and PCBs, require more attention in Taihu Lake than the other target contaminants.
authors.affiliation: Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China. Electronic address: yuyingxin@staff.shu.edu.cn.
authors.forename: Yingxin
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.affiliation: Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Bingli
authors.initials: B
authors.lastname: Lei
authors.affiliation: Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D002273:Carcinogens / Q000032:analysis*; D002648:Child; D002681:China; D003634:DDT / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005396:Fish Products / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis; D060106:Lakes; D008670:Metals / Q000032:analysis; D019055:No-Observed-Adverse-Effect Level; D010575:Pesticides / Q000032:analysis; D011078:Polychlorinated Biphenyls / Q000032:analysis; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis; D018570:Risk Assessment / Q000379:methods*; D035501:Uncertainty; D014874:Water Pollutants, Chemical / Q000032:analysis
chemical_list: D002273:Carcinogens; D006843:Hydrocarbons, Chlorinated; D008670:Metals; D010575:Pesticides; D011084:Polycyclic Aromatic Hydrocarbons; D014874:Water Pollutants, Chemical; D003634:DDT; D011078:Polychlorinated Biphenyls
keywords: Bioaccessibility; Health risk assessment; Persistent organic pollutant; Taihu Lake; Toxic trace element