title: Phenolic constituents from the roots of Phyllodium pulchellum.
abstract: Three new phenolic constituents 1-3 were obtained from the 95% ethanol extract of the roots of Phyllodium pulchellum (Leguminosae). Their structures were elucidated on the basis of spectroscopic analyses, such as NMR, UV, IR, HR-ESI-MS, and CD. Furthermore, in an in vitro bioassay, all compounds were tested for inhibitory effects against the proliferation of acetaldehyde-stimulated HSC-T6 cells, and compound 3 exhibited potent inhibitory activity with the IC50 value of 7.6 μM.
authors.affiliation: a College of Pharmacy, Dalian Medical University , Dalian 116044 , China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zong
authors.forename: Ming
authors.initials: M
authors.lastname: Zhong
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Li
authors.forename: Bao-Jing
authors.initials: BJ
authors.lastname: Zhang
authors.forename: Zhen-Peng
authors.initials: ZP
authors.lastname: Mai
authors.forename: Xiao-Kui
authors.initials: XK
authors.lastname: Huo
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Huang
authors.forename: Hou-Li
authors.initials: HL
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Xiao-Chi
authors.initials: XC
authors.lastname: Ma
authors.forename: Sheng-Min
authors.initials: SM
authors.lastname: Yu
authors.forename: Dong-Ai
authors.initials: DA
authors.lastname: Yang
mesh_terms: D000079:Acetaldehyde / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D010636:Phenols; D010936:Plant Extracts; D000079:Acetaldehyde
keywords: Phyllodium pulchellum; anti-liver fibrosis; phenolic