title: Low temperature plasma: a novel focal therapy for localized prostate cancer?
abstract: Despite considerable advances in recent years for the focal treatment of localized prostate cancer, high recurrence rates and detrimental side effects are still a cause for concern. In this review, we compare current focal therapies to a potentially novel approach for the treatment of early onset prostate cancer: low temperature plasma. The rapidly evolving plasma technology has the potential to deliver a wide range of promising medical applications via the delivery of plasma-induced reactive oxygen and nitrogen species. Studies assessing the effect of low temperature plasma on cell lines and xenografts have demonstrated DNA damage leading to apoptosis and reduction in cell viability. However, there have been no studies on prostate cancer, which is an obvious candidate for this novel therapy. We present here the potential of low temperature plasma as a focal therapy for prostate cancer.
authors.affiliation: Department of Physics, York Plasma Institute, University of York, Heslington, York YO10 5DD, UK.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Hirst
authors.affiliation: YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, UK.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Frame
authors.affiliation: YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, UK.
authors.forename: Norman J
authors.initials: NJ
authors.lastname: Maitland
authors.affiliation: Department of Physics, York Plasma Institute, University of York, Heslington, York YO10 5DD, UK.
authors.forename: Deborah
authors.initials: D
authors.lastname: O'Connell
mesh_terms: D017209:Apoptosis / Q000235:genetics; D003080:Cold Temperature; D017679:Cryotherapy; D004249:DNA Damage; D006801:Humans; D008297:Male; D010778:Photochemotherapy; D011471:Prostatic Neoplasms / Q000473:pathology / Q000628:therapy*; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species
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