title: Embedded carbon nanotubes nanoparticles in plasma membrane induce cellular calcium outflow imbalancing.
abstract: In this report, embedded single-wall carbon nanotubes (SWCNTs) nanoparticles in plasma membrane inducing cellular calcium outflow imbalancing are disclosed. Compared ssDNA-SWCNTs with polystyrene (PS) nanoparticles, we analyzed the cytotoxicity of these nanoparticles and the effect of these nanoparticles on intracellular Ca2+ ion levels by depletion of Ca2+ from the endoplasmic reticulum (ER) evoked by Thapsigargin (Tg) in SKN-SH cells. The results had shown that ssDNA-SWCNTs and PS nanoparticles have no cytotoxicity on SKN-SH cells. However, contrary to PS nanoparticles, cellular Ca2+ ion outflow imbalancing was investigated in SKN-SH cells after pretreated with ssDNA-SWCNTs induced by Tg, which could be proposed mainly due to the interaction of embedded ssDNA-SWCNTs with cellular membrane.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Wang
authors.forename: Ru
authors.initials: R
authors.lastname: Liu
authors.forename: Yunming
authors.initials: Y
authors.lastname: Su
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008422:Materials Testing; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D037742:Nanotubes, Carbon; D002118:Calcium