title: Illness insight and neurophysiological error-processing deficits in schizophrenia.
abstract: Impaired illness insight in schizophrenia is associated with non-adherence and worse outcomes. Schizophrenia patients also exhibit error-monitoring deficits, which have been proposed to cause poor insight. To test this hypothesis, we examined whether schizophrenia patients' deficits in neurophysiological error-monitoring indices, the error-related negativity (ERN) and error positivity (Pe) event-related potential (ERP) amplitudes, are associated with impaired insight. ERPs were recorded in 18 schizophrenia patients and 18 normal comparison participants during a Stroop task. Patients' subnormal ERN and Pe amplitudes did not correlate with insight, suggesting that impaired insight in schizophrenia stems from neurocognitive mechanisms other than deficient error monitoring.
authors.affiliation: Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
authors.forename: Vinay
authors.initials: V
authors.lastname: Kansal
authors.affiliation: St. Joseph's Healthcare, Hamilton, Ontario L8N 3K7, Canada.
authors.forename: Iulia
authors.initials: I
authors.lastname: Patriciu
authors.affiliation: Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada; St. Joseph's Healthcare, Hamilton, Ontario L8N 3K7, Canada. Electronic address: michael.kiang@camh.ca.
authors.forename: Michael
authors.initials: M
authors.lastname: Kiang
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000209:etiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011340:Problem Solving; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D013223:Statistics as Topic
keywords: Cognition; Electrophysiology; Error positivity; Error processing; Error-related negativity; Event-related potentials; Illness insight; Neurophysiology; Schizophrenia