title: Muscle matters in Kennedy's disease.
abstract: Polyglutamine expansion in the androgen receptor causes Kennedy's disease. Two recent reports, Cortes et al. (2014) in this issue of Neuron and Lieberman et al. (2014) in Cell Reports, raise the possibility that targeting expression of the mutant protein in skeletal muscle, instead of the nervous system, may mitigate manifestations of this disorder.
authors.affiliation: Neurogenetics Branch, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Carlo
authors.initials: C
authors.lastname: Rinaldi
authors.affiliation: Neurogenetics Branch, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA; Department of Cell and Molecular Biology, Karolinska Institute, 17177 Stockholm, Sweden.
authors.forename: Laura C
authors.initials: LC
authors.lastname: Bott
authors.affiliation: Neurogenetics Branch, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: kf@ninds.nih.gov.
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Fischbeck
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D020966:Muscular Disorders, Atrophic / Q000235:genetics* / Q000473:pathology*; D010455:Peptides / Q000235:genetics*; D011944:Receptors, Androgen / Q000235:genetics*
chemical_list: D010455:Peptides; D011944:Receptors, Androgen; C097188:polyglutamine
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