title: RORs in autoimmune disease.
abstract: The retinoic acid receptor-related orphan receptor (ROR) subfamily of nuclear receptors are transcription factors involved in the maintenance of circadian rhythm and are essential for proper immune function. The T cell-specific isoform, RORγt, is required for T helper 17 cells (TH17) development and it has been implicated in the pathogenesis of autoimmune diseases including multiple sclerosis and rheumatoid arthritis. Thus, pharmacological repression of RORγt may provide a strategy for therapeutic intervention in autoimmune disorders. This chapter provides a summary of the current status for target validation and development of new chemical entities targeting RORγt.
authors.affiliation: Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, FL, 33458, USA.
authors.forename: Mi Ra
authors.initials: MR
authors.lastname: Chang
authors.forename: Hugh
authors.initials: H
authors.lastname: Rosen
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Griffin
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology*; D006801:Humans; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology
chemical_list: D057132:Nuclear Receptor Subfamily 1, Group F, Member 3