title: Invasive Geotrichum clavatum fungal infection in an acute myeloid leukaemia patient: a case report and review.
abstract: Invasive Geotrichum clavatum fungal infections are extremely rare and unusual, occurring nearly exclusively in patients experiencing prolonged neutropenia during the treatment for acute myeloid leukaemia. Several groups of cases of fatal G. clavatum infection were reported in France between 2011 and 2012, but the ecological niche has not yet been identified. We report a case of a 32-year-old patient with acute myeloid leukaemia who developed G. clavatum sepsis with primary peritonitis, hepatic nodular lesions, and multivisceral failure during aplasia after induction followed by salvage chemotherapy. He was treated with voriconazole and is still alive 1 year after with controlled disease. We then discuss the epidemiological, clinical, and therapeutic features of these serious fungal infections compared to the published data.
authors.affiliation: Department of Hematology, Centre Henri Becquerel, rue d'Amiens, 76038, Rouen, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Camus
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Thibault
authors.forename: Marion
authors.initials: M
authors.lastname: David
authors.forename: Gilles
authors.initials: G
authors.lastname: Gargala
authors.forename: Patricia
authors.initials: P
authors.lastname: Compagnon
authors.forename: Fabien
authors.initials: F
authors.lastname: Lamoureux
authors.forename: Christophe
authors.initials: C
authors.lastname: Girault
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Michot
authors.forename: Aspasia
authors.initials: A
authors.lastname: Stamatoullas
authors.forename: Hélène
authors.initials: H
authors.lastname: Lanic
authors.forename: Fabrice
authors.initials: F
authors.lastname: Jardin
authors.forename: Pascal
authors.initials: P
authors.lastname: Lenain
authors.forename: Hervé
authors.initials: H
authors.lastname: Tilly
authors.forename: Stéphane
authors.initials: S
authors.lastname: Leprêtre
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D005847:Geotrichosis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D005848:Geotrichum / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D065819:Voriconazole / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D065819:Voriconazole
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