title: A specific role for hippocampal mossy fiber's zinc in rapid storage of emotional memories.
abstract: We investigated the specific role of zinc present in large amounts in the synaptic vesicles of mossy fibers and coreleased with glutamate in the CA3 region. In previous studies, we have shown that blockade of zinc after release has no effect on the consolidation of spatial learning, while zinc is required for the consolidation of contextual fear conditioning. Although both are hippocampo-dependent processes, fear conditioning to the context implies a strong emotional burden. To verify the hypothesis that zinc could play a specific role in enabling sustainable memorization of a single event with a strong emotional component, we used a neuropharmacological approach combining a glutamate receptor antagonist with different zinc chelators. Results show that zinc is mandatory to allow the consolidation of one-shot memory, thus being the key element allowing the hippocampus submitted to a strong emotional charge to switch from the cognitive mode to a flashbulb memory mode. Individual differences in learning abilities have been known for a long time to be totally or partially compensated by distributed learning practice. Here we show that contextual fear conditioning impairments due to zinc blockade can be efficiently reduced by distributed learning practice.
authors.affiliation: Université de Toulouse, UPS, Centre de Recherches sur la Cognition Animale, F-31062 Toulouse Cedex 9, France.
authors.forename: Johnatan
authors.initials: J
authors.lastname: Ceccom
authors.forename: Hélène
authors.initials: H
authors.lastname: Halley
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Daumas
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Lassalle
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004050:Ditiocarb / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D004644:Emotions / Q000502:physiology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D019599:Mossy Fibers, Hippocampal / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology; D015032:Zinc / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D002614:Chelating Agents; D018691:Excitatory Amino Acid Antagonists; C056639:2-amino-5-phosphopentanoic acid; D004050:Ditiocarb; D004492:Edetic Acid; D014633:Valine; D015032:Zinc
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