title: [Association between chronic periodontitis and metabolic syndrome related mitochondria single nucleotide polymorphism].
abstract: OBJECTIVE
  To investigate the relationship between Mitochondrial DNA(mtDNA) SNP and the severity of periodontitis.
  
  
  METHODS
  In the study, 227 subjects in a community of Beijing received questionnaire interview, periodontal examination and biochemical laboratory examination in 2005. The designed primer was used to amplify the specific mtDNA fragments with PCR, and sequence the PCR products. Finally, the relationship between severity of chronic periodontitis and mtDNA SNP at site 10398 was analyzed.
  
  
  RESULTS
  The number of the subjects included at mtDNA site 10398 was 227. The G allele frequency in the metabolic syndrome(MS) subjects was significantly higher than that in the non MS subjects [80(70.2%) vs. 34(29.8%),P=0.039 ]. The result of Logistic regression showed that the subjects with G allele had higher risk of MS than the subjects with A allele(OR=1.77,95%CI=1.02-3.06, P=0.042). But there was no significant relationship between the 10398 A→G SNP and severity of periodontitis.
  
  
  CONCLUSIONS
  In this population, mtDNA SNP 10398 A→G may be associated with MS. However, there was no relationship between the 10398 A→G SNP and severity of chronic periodontitis.
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Yan
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Qing-xian
authors.initials: QX
authors.lastname: Luan
authors.affiliation: Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing 100043, China.
authors.forename: Li-shen
authors.initials: LS
authors.lastname: Liu
authors.affiliation: Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing 100043, China.
authors.forename: Xing-yu
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Second Clinical Division, Peking University School and Hospital of Stomatology, Beijing 100101,China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Yue-qin
authors.initials: YQ
authors.lastname: Sha
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000150:complications / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D016015:Logistic Models; D024821:Metabolic Syndrome / Q000150:complications / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: D004272:DNA, Mitochondrial