title: Role of angiotensin modulation in primary headaches.
abstract: The renin-angiotensin system (RAS) is a major regulatory system controlling many different homeostatic mechanisms both within the brain and in the periphery. While it is primarily associated with blood pressure and salt/water regulation, increasing evidence points to the involvement of the RAS in both headache disorders specifically and pain regulation in general. Several publications have indicated that drugs blocking various elements of the renin-angiotensin system lead to a reduction in migraine. Additionally, interventions on different angiotensin peptides or their receptors have been shown to both reduce and increase pain in animal models. As such, modulation of the renin-angiotensin system is a promising approach to the treatment of headaches and other pain conditions.
authors.affiliation: Norwegian National Headache Centre, Department of Neurology, St. Olavs Hospital, Trondheim, Norway, erling.tronvik@ntnu.no.
authors.forename: Erling
authors.initials: E
authors.lastname: Tronvik
authors.forename: Lars Jacob
authors.initials: LJ
authors.lastname: Stovner
mesh_terms: D000809:Angiotensins / Q000378:metabolism; D051270:Headache Disorders, Primary / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D012084:Renin-Angiotensin System / Q000502:physiology*
chemical_list: D000809:Angiotensins
references.citation: J Pharmacol Sci. 2012;119(2):117-21
references.pmid: 22673132
references.citation: Hypertension. 2001 Apr;37(4):1141-6
references.pmid: 11304516
references.citation: Pain. 2011 Jan;152(1):140-149
references.pmid: 21036476
references.citation: Neurosci Lett. 2005 Feb 10;374(2):129-31
references.pmid: 15644278
references.citation: Neuropeptides. 2013 Apr;47(2):93-7
references.pmid: 23375440
references.citation: Cephalalgia. 1981 Dec;1(4):229-32
references.pmid: 6181894
references.citation: Regul Pept. 2009 Apr 10;154(1-3):23-31
references.pmid: 19323983
references.citation: Peptides. 1999;20(3):335-42
references.pmid: 10447091
references.citation: Peptides. 2012 Jul;36(1):9-16
references.pmid: 22484286
references.citation: Int J Prev Med. 2013 Jan;4(1):72-7
references.pmid: 23413003
references.citation: Eur J Pain. 2013 Aug;17(7):1012-26
references.pmid: 23255326
references.citation: Mol Cell Biochem. 2010 Jan;334(1-2):221-32
references.pmid: 20012469
references.citation: J Pharmacol Exp Ther. 2013 Jan;344(1):141-54
references.pmid: 23055539
references.citation: Cephalalgia. 2007 Jun;27(6):535-41
references.pmid: 17459083
references.citation: Protein Cell. 2013 Jul;4(7):520-8
references.pmid: 23744339
references.citation: Peptides. 2013 Jan;39:21-8
references.pmid: 23142109
references.citation: Transl Res. 2009 Sep;154(3):142-52
references.pmid: 19665690
references.citation: Headache. 2006 Mar;46(3):503-7
references.pmid: 16618270
references.citation: Neuroscience. 2013 Feb 12;231:315-27
references.pmid: 23219939
references.citation: Clin Sci (Lond). 2013 Jul 1;125(2):57-65
references.pmid: 23530669
references.citation: JAMA. 2003 Jan 1;289(1):65-9
references.pmid: 12503978
references.citation: Brain Res. 1992 Jan 13;569(2):255-67
references.pmid: 1347242
references.citation: J Hypertens Suppl. 1986 Dec;4(6):S468-71
references.pmid: 2441017
references.citation: Brain Res. 1989 Jan 2;476(1):1-9
references.pmid: 2563331
references.citation: Am J Med. 2002 Jun 1;112(8):642-6
references.pmid: 12034414
references.citation: Lancet. 2012 Dec 15;380(9859):2163-96
references.pmid: 23245607
references.citation: Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):37-41
references.pmid: 9164552
references.citation: Regul Pept. 2010 Jun 8;162(1-3):90-8
references.pmid: 20346377
references.citation: Pain. 2008 Nov 30;140(2):265-273
references.pmid: 18823708
references.citation: Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1416-24
references.pmid: 17496218
references.citation: Neuropeptides. 2009 Apr;43(2):81-92
references.pmid: 19230969
references.citation: Cephalalgia. 2003 Nov;23(9):901-6
references.pmid: 14616932
references.citation: Headache. 1995 Sep;35(8):470-1
references.pmid: 7591740
references.citation: J Mol Neurosci. 2012 Sep;48(1):53-65
references.pmid: 22528462
references.citation: Pharmacol Biochem Behav. 1999 Feb;62(2):229-32
references.pmid: 9972688
references.citation: Hypertens Res. 2004 Jun;27(6):441-6
references.pmid: 15253110
references.citation: Cephalalgia. 2009 Sep;29(9):921-7
references.pmid: 19250283
references.citation: Neuroscience. 2009 Feb 18;158(4):1301-10
references.pmid: 19116162
references.citation: Eur J Neurosci. 2009 Sep;30(6):1056-63
references.pmid: 19723290
references.citation: BMJ. 2001 Jan 6;322(7277):19-22
references.pmid: 11141144
references.citation: Eur Neurol. 2000;43(3):133-6
references.pmid: 10765051
references.citation: Brain Res. 2003 May 16;972(1-2):207-15
references.pmid: 12711094
references.citation: Headache. 2013 Jan;53(1):161-164
references.pmid: 23278516
references.citation: Regul Pept. 2005 Jul 15;129(1-3):1-7
references.pmid: 15927691
references.citation: Neuroscience. 2005;132(2):453-63
references.pmid: 15802196
references.citation: Pain. 1986 Nov;27(2):237-245
references.pmid: 3540814
references.citation: Pain. 2007 Apr;128(3):209-214
references.pmid: 17123735
references.citation: Pharmacoepidemiol Drug Saf. 2004 Jan;13(1):41-7
references.pmid: 14971122
references.citation: Am J Physiol Renal Physiol. 2003 Sep;285(3):F472-83
references.pmid: 12746258
references.citation: Headache. 2009 Feb;49(2):292-9
references.pmid: 19178574
references.citation: Pain. 2000 Apr;85(3):465-469
references.pmid: 10781920
references.citation: Neurosci Lett. 1993 Sep 3;159(1-2):9-12
references.pmid: 8264986
references.citation: Neurology. 2002 Mar 26;58(6):885-94
references.pmid: 11914403
references.citation: Learn Mem. 2010 Jun 30;17(7):355-63
references.pmid: 20592054
references.citation: Neurosci Lett. 2010 May 26;476(1):32-5
references.pmid: 20371376
references.citation: Peptides. 2013 Aug;46:26-32
references.pmid: 23692861
references.citation: J Neurochem. 2012 Jan;120(1):46-55
references.pmid: 22026649
references.citation: Headache. 2007 Jul-Aug;47(7):1008-23; discussion 24-5
references.pmid: 17635592
references.citation: Life Sci. 2000 Oct 13;67(21):2577-85
references.pmid: 11104359
references.citation: Am J Med Genet. 2000 Dec 4;96(6):762-4
references.pmid: 11121176
references.citation: Am J Physiol Cell Physiol. 2011 Jan;300(1):C58-64
references.pmid: 20980550
references.citation: Mol Pain. 2013 Jul 31;9:38
references.pmid: 23898828
references.citation: BMC Neurol. 2008 Mar 26;8:4
references.pmid: 18366776
references.citation: Cephalalgia. 2013 Sep;33(12):1026-34
references.pmid: 23598371