title: [Changes of epidermal growth factor level in blood serum, saliva and gastric juice in children with duodenal ulcer].
abstract: OBJECTIVE
  The aim of our study is to investigate EGF content in biological mediums in children with duodenum ulcer depending on phase of the disease and different variants of its course.
  
  
  METHODS
  The present study was performed in Federal State Establishment "Nizhniy Novgorod Research Institute of Children Gastroenterology", Nizhniy Novgorod, Russia. 92 children, between the ages of 8 to 17, with duodenum ulcer were under observation. Endoscopy was performed by Pentax endoscope (FG-24V). EGF detection was performed in blood serum, gastric juice and saliva by ELISA method with Human EGF Kit, "Invitrogen", USA.
  
  
  RESULTS
  The peculiarities of EGF level changes in human biological mediums, depending on phase of the disease. The highest EGF level was detected with acute peptic ulcer in the presence of ulcerous defects. EGF level increasing was marked out in the remission phaseas ulcerous defects healing, and it didn't reach normal values in gastric juice. EGF content changes in biological mediums were revealed with different variants of duodenum ulcer clinical course in children. The lowest EGF level was marked out in blood, saliva and gastric juice with unfavorable course of the disease (frequent relapses, cicatricial-ulcerous strains formation), which can serve as a prognostic factor.
authors.forename: E A
authors.initials: EA
authors.lastname: Zhukova
authors.forename: T A
authors.initials: TA
authors.lastname: Vidmanova
authors.forename: I N
authors.initials: IN
authors.lastname: Viskova
authors.forename: S A
authors.initials: SA
authors.lastname: Kolesov
authors.forename: L V
authors.initials: LV
authors.lastname: Korkotashvili
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Shirokova
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Kan'kova
mesh_terms: D000293:Adolescent; D002648:Child; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D016145:Endoscopy, Digestive System / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D004815:Epidermal Growth Factor / Q000032:analysis / Q000378:metabolism; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D008297:Male; D062072:Patient Acuity; D012463:Saliva / Q000378:metabolism*; D044967:Serum / Q000378:metabolism*; D014945:Wound Healing
chemical_list: D004815:Epidermal Growth Factor