title: Heterogeneity of cardiovascular risk factors profile in non-diabetic women 2-24 months post gestational diabetes mellitus.
abstract: Previously gestational diabetic (pGDM) women are characterized by high cardiovascular risk (CVR). The aim of this study was to assess the CVR markers levels in non-diabetic pGDM women in relation to time postpartum and to soluble E-selectin (sES) level. We investigated 125 women aged 18-40 years with a history of GDM between 2 and 24 months after their pregnancy. We evaluated age, body mass index (BMI), waist circumference, glucose levels during the oral glucose tolerance test (OGTT), levels of insulin and the parameters of endothelial dysfunction, fibrinolysis activity, low-grade systemic inflammation and lipid profiles. Prediabetes was identified in 38 women (30%), while in the remaining women OGTT results were normal. The tests performed >6 months revealed decreased hs-CRP (p = 0.01), sICAM-1 (p = 0.01), and elevated sES (p = 0.01) >12 months after adjustment for age, BMI, waist circumference and 2 h OGTT glucose. In the subgroup tested ≤12 months after an index pregnancy sES was independently associated with hs-CRP (p < 0.0001) and triglycerides (p = 0.0139). No association was found between sES and remaining parameters in women tested >12 months postpartum. We conclude that the period 2-24 months post GDM is heterogeneous with respect to the CVR markers. The plasma level of hs-CRP could be useful as an important cardiovascular risk marker up to 12 months postpartum in non-diabetic pGDM women.
authors.affiliation: Department of Gastroenterology, Angiology and Internal Diseases, Dr J. Biziel University Hospital, Nicolaus Copernicus University, Bydgoszcz, Poland .
authors.forename: Alina
authors.initials: A
authors.lastname: Sokup
authors.forename: Barbara
authors.initials: B
authors.lastname: Ruszkowska-Ciastek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Walentowicz-Sadłecka
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood*; D019040:E-Selectin / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D049590:Postpartum Period; D011247:Pregnancy; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D019040:E-Selectin; D007328:Insulin; D014280:Triglycerides; D005340:Fibrinogen; D002097:C-Reactive Protein