title: Systemic sclerosis with normal or nonspecific nailfold capillaroscopy.
abstract: BACKGROUND
  In systemic sclerosis (SSc), a specific nailfold videocapillaroscopy (NVC) pattern is observed in 90% of cases and seems to be associated with severity and progression of the disease.
  
  
  OBJECTIVE
  To describe the characteristics of SSc patients with normal or nonspecific (normal/nonspecific) NVC.
  
  
  METHODS
  In a retrospective cohort study, clinical features and visceral involvements of 25 SSc cases with normal/nonspecific NVC were compared to 63 SSc controls with the SSc-specific NVC pattern.
  
  
  RESULTS
  Normal/nonspecific NVC versus SSc-specific NVC pattern was significantly associated with absence of skin sclerosis (32 vs. 6.3%, p = 0.004), absence of telangiectasia (47.8 vs. 17.3%, p = 0.006) and absence of sclerodactyly (60 vs. 25.4%, p = 0.002), and less frequent severe pulmonary involvement (26.3 vs. 58.2%, p = 0.017).
  
  
  CONCLUSIONS
  Normal/nonspecific NVC in SSc patients appears to be associated with less severe skin involvement and less frequent severe pulmonary involvement.
authors.affiliation: Department of Dermatology, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Fichel
authors.forename: Nathalie
authors.initials: N
authors.lastname: Baudot
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Gaitz
authors.forename: Salim
authors.initials: S
authors.lastname: Trad
authors.forename: Coralie
authors.initials: C
authors.lastname: Barbe
authors.forename: Camille
authors.initials: C
authors.lastname: Francès
authors.forename: Patricia
authors.initials: P
authors.lastname: Senet
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D020678:Microscopic Angioscopy; D018715:Microscopy, Video; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D009262:Nails / Q000098:blood supply*; D011928:Raynaud Disease / Q000276:immunology / Q000473:pathology*; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012595:Scleroderma, Systemic / Q000276:immunology / Q000473:pathology*; D012720:Severity of Illness Index; D013684:Telangiectasis / Q000473:pathology
chemical_list: D000974:Antibodies, Antinuclear