title: Genome-wide association scan for variants associated with early-onset prostate cancer.
abstract: Prostate cancer is the most common non-skin cancer and the second leading cause of cancer related mortality for men in the United States. There is strong empirical and epidemiological evidence supporting a stronger role of genetics in early-onset prostate cancer. We performed a genome-wide association scan for early-onset prostate cancer. Novel aspects of this study include the focus on early-onset disease (defined as men with prostate cancer diagnosed before age 56 years) and use of publically available control genotype data from previous genome-wide association studies. We found genome-wide significant (p<5×10(-8)) evidence for variants at 8q24 and 11p15 and strong supportive evidence for a number of previously reported loci. We found little evidence for individual or systematic inflated association findings resulting from using public controls, demonstrating the utility of using public control data in large-scale genetic association studies of common variants. Taken together, these results demonstrate the importance of established common genetic variants for early-onset prostate cancer and the power of including early-onset prostate cancer cases in genetic association studies.
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America; Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors.forename: Ethan M
authors.initials: EM
authors.lastname: Lange
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Johnson
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America; Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Zuhlke
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors.forename: Yurong
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors.forename: Jessica V
authors.initials: JV
authors.lastname: Ribado
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Keele
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors.forename: Qing
authors.initials: Q
authors.lastname: Duan
authors.affiliation: Center for Genomics and Personalized Medicine Research, Wake Forest University, Winston-Salem, North Carolina, United States of America.
authors.forename: Ge
authors.initials: G
authors.lastname: Li
authors.affiliation: Center for Genomics and Personalized Medicine Research, Wake Forest University, Winston-Salem, North Carolina, United States of America.
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America; Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Center for Genomics and Personalized Medicine Research, Wake Forest University, Winston-Salem, North Carolina, United States of America.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Urology, Johns Hopkins University, Baltimore, Maryland, United States of America.
authors.forename: William B
authors.initials: WB
authors.lastname: Isaacs
authors.affiliation: Center for Genomics and Personalized Medicine Research, Wake Forest University, Winston-Salem, North Carolina, United States of America.
authors.forename: Siqun
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America; Department of Urology, University of Michigan, Ann Arbor, Michigan, United States of America.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Cooney
mesh_terms: D000328:Adult; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*
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