title: Review of psychodynamic psychotherapy neuroimaging studies.
abstract: The clinical efficacy of psychodynamic psychotherapy (PDT) has undergone extensive study and review. Recently, researchers have studied the effects of this treatment on brain metabolic or synaptic activity, but the collective findings have never been reviewed. The objective of this review was to describe the findings of all neuroimaging studies of any form of PDT treatment. An extensive literature search through databases along with surveying of research groups were undertaken to acquire all available published studies. Eleven series were included in the final sample, consisting of 2 randomized controlled trials, 5 controlled trials and 4 case series, altogether involving 210 people: 94 healthy controls and 116 people with mood disorders, panic disorder, somatoform disorders and borderline personality disorder. A variety of neuroimaging techniques were used to examine regional metabolic activity and synaptic neurotransmission before and after treatment. The common finding was normalization of synaptic or metabolic activity in limbic, midbrain and prefrontal regions, occurring in association with improved clinical outcomes. PDT has demonstrable effects on brain function in diverse clinical populations as evidenced by a modest group of mixed neuroimaging studies.
authors.affiliation: Department of Psychiatry, Dalhousie University, Halifax, N.S., Canada.
authors.forename: Allan A
authors.initials: AA
authors.lastname: Abbass
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Nowoweiski
authors.forename: Denise
authors.initials: D
authors.lastname: Bernier
authors.forename: Robert
authors.initials: R
authors.lastname: Tarzwell
authors.forename: Manfred E
authors.initials: ME
authors.lastname: Beutel
mesh_terms: D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D001523:Mental Disorders / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D050480:Plasma Membrane Neurotransmitter Transport Proteins / Q000378:metabolism; D064889:Psychotherapy, Psychodynamic; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D050480:Plasma Membrane Neurotransmitter Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A