title: [Disinfection of water: on the need for analysis and solution of fundamental and applied problems].
abstract: In the paper there is presented an analysis of hygienic--medical and environmental aspects of water disinfection as exemplified of chlorine and chlorine dioxide (CD). The concept of persistent multivariate risk for aquatic pathogens, the own vision of the mechanism of formation of chlorine resistance of bacteria under the influence of biocides based on a two-step process of information and spatial interaction of the receptor and the substrate, the hypothesis of hormetic stimulating effect of residual active chlorine (in the complex with other factors) on the growth of aquatic pathogens have been proposed. The aggravation of the significance of halogen containing compounds (HCC) as byproducts of water chlorination in terms of their potential danger as toxicants and carcinogens has been substantiated. Analysis of hygienic and medical and environmental aspects of the use of chlorine dioxide as a means of disinfection of water allowed to justify chemism of its biocidal effect and mechanisms of bactericidal, virucidal, protozoocidal, sporicidal, algacidal actions, removal of biofilms, formation of disinfection byproducts. Chlorine dioxide was shown both to provide epidemic safety of drinking water due to its high virucidal, bactericidal and mycocidal action and to be toxicologically harmless in the context of the influence on the organism of laboratory animals as well as in relation to aquatic organisms under the discharge of disinfected wastewater. There has proved the necessity of the close relationship of fundamental and applied research in performing the first in terms of depth study of microbiological, molecular genetic and epidemiological problems of disinfection (chlorination) of water and the implementation of the latters by means of the introduction of alternative, including combined, technologies for water treatment and disinfection.
authors.forename: A V
authors.initials: AV
authors.lastname: Mokienko
mesh_terms: D000818:Animals; D018441:Biofilms; D002713:Chlorine / Q000737:chemistry; D017606:Chlorine Compounds / Q000737:chemistry; D004202:Disinfectants / Q000737:chemistry; D004203:Disinfection / Q000379:methods*; D006801:Humans; D010087:Oxides / Q000737:chemistry; D014867:Water / Q000592:standards*; D014871:Water Microbiology; D018508:Water Purification / Q000379:methods*; D014881:Water Supply / Q000592:standards*
chemical_list: D017606:Chlorine Compounds; D004202:Disinfectants; D010087:Oxides; D014867:Water; D002713:Chlorine; C025109:chlorine dioxide