title: The value of soluble transferrin receptor and hepcidin in the assessment of iron status in children with cystic fibrosis.
abstract: BACKGROUND
  The value of ferritin in the diagnosis of iron deficiency is limited in patients with CF since it increases in the presence of inflammation. We hypothesized that the soluble transferrin receptor (sTfR) and hepcidin may provide more information than ferritin in assessing iron status in children with CF.
  
  
  METHODS
  We analyzed sTfR and hepcidin in relation to conventional iron status indicators in 49 children with CF.
  
  
  RESULTS
  We found no differences in sTfR concentration between children with and those without ID. sTfR concentrations were within the normal range in all children. Hepcidin concentrations were low, and concentrations below the limit of detection were observed in 25% of the clinically stable children.
  
  
  CONCLUSIONS
  The sTfR is not useful to determine the iron status in this population, whereas hepcidin might serve as an early indicator of deficient iron stores in children with CF.
authors.affiliation: Department of Pediatrics, Juliana Children's Hospital/HAGA Teaching Hospital, Sportlaan 600, 2566 MJ The Hague, The Netherlands. Electronic address: l.uijterschout@hagaziekenhuis.nl.
authors.forename: Lieke
authors.initials: L
authors.lastname: Uijterschout
authors.affiliation: Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic Diseases, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands; Hepcidinanalysis.com, Geert Grooteplein 10 (830), 6525 GA Nijmegen, The Netherlands.
authors.forename: Dorine W
authors.initials: DW
authors.lastname: Swinkels
authors.affiliation: Department of Pediatrics, Juliana Children's Hospital/HAGA Teaching Hospital, Sportlaan 600, 2566 MJ The Hague, The Netherlands.
authors.forename: Marjolijn D
authors.initials: MD
authors.lastname: Akkermans
authors.affiliation: Department of Pediatrics, Juliana Children's Hospital/HAGA Teaching Hospital, Sportlaan 600, 2566 MJ The Hague, The Netherlands.
authors.forename: Thomas
authors.initials: T
authors.lastname: Zandstra
authors.affiliation: Department of Pediatrics, Juliana Children's Hospital/HAGA Teaching Hospital, Sportlaan 600, 2566 MJ The Hague, The Netherlands.
authors.forename: Marianne
authors.initials: M
authors.lastname: Nuijsink
authors.affiliation: Department of Pediatrics, Juliana Children's Hospital/HAGA Teaching Hospital, Sportlaan 600, 2566 MJ The Hague, The Netherlands.
authors.forename: Daniëlle
authors.initials: D
authors.lastname: Hendriks
authors.affiliation: Department of Clinical Chemistry, HAGA Hospital, Sportlaan 600, 2566 MJ The Hague, The Netherlands.
authors.forename: Cisca
authors.initials: C
authors.lastname: Hudig
authors.affiliation: Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic Diseases, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands; Hepcidinanalysis.com, Geert Grooteplein 10 (830), 6525 GA Nijmegen, The Netherlands.
authors.forename: Harrold
authors.initials: H
authors.lastname: Tjalsma
authors.affiliation: HagaAcademy, Haga Teaching Hospital, The Hague, The Netherlands.
authors.forename: Rimke
authors.initials: R
authors.lastname: Vos
authors.affiliation: Department of Pediatrics, VU University Medical Center, De Boelelaan 1117, 1081 HZ Amsterdam, The Netherlands; Department of Pediatrics, Emma Children's Hospital - Academic Medical Center, Meidreefweg 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Johannes B
authors.initials: JB
authors.lastname: van Goudoever
authors.affiliation: Department of Pediatrics, Juliana Children's Hospital/HAGA Teaching Hospital, Sportlaan 600, 2566 MJ The Hague, The Netherlands.
authors.forename: Frank
authors.initials: F
authors.lastname: Brus
mesh_terms: D000293:Adolescent; D018798:Anemia, Iron-Deficiency / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D005260:Female; D005293:Ferritins / Q000097:blood; D064451:Hepcidins / Q000097:blood*; D006801:Humans; D008297:Male; D011990:Receptors, Transferrin / Q000097:blood*
chemical_list: D015415:Biomarkers; D064451:Hepcidins; D011990:Receptors, Transferrin; D002097:C-Reactive Protein; D005293:Ferritins
keywords: Anemia; Children; Ferritin; Hepcidin; Pseudomonas aeruginosa; Reticulocyte hemoglobin content; Soluble transferrin receptor