title: Cortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity.
abstract: The cerebral cortex contains dozens of neuronal subtypes grouped in specific layers and areas. Recent studies have revealed how embryonic and induced pluripotent stem cells (PSC) can differentiate into a wide diversity of cortical neurons in vitro, while recapitulating many of the temporal and spatial features that characterize corticogenesis. PSC-derived neurons can integrate into the brain following in vivo transplantation and display patterns of morphology and connectivity specific of cortical neurons. PSC-corticogenesis thus emerges as a robust model that provides new ways to link cortical development, evolution, and disease.
authors.affiliation: Children's Hospital of Philadelphia, UPenn School of Medicine, Philadelphia, PA 19104-5127, United States. Electronic address: sande@mail.med.upenn.edu.
authors.forename: Stewart
authors.initials: S
authors.lastname: Anderson
authors.affiliation: Université Libre de Bruxelles (ULB), WELBIO, Institute for Interdisciplinary Research (IRIBHM), and ULB Institute of Neuroscience (UNI), 808 Route de Lennik, B-1070 Brussels, Belgium. Electronic address: pierre.vanderhaeghen@ulb.ac.be.
authors.forename: Pierre
authors.initials: P
authors.lastname: Vanderhaeghen
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*
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