title: Pathological features of the sessile serrated adenoma/polyp with special references of its carcinogenesis.
abstract: The sessile serrated adenoma/polyp (SSA/P) has been thought as the relatively new precursor for the colorectal cancer. In the current review, the well-known pathological features including the histological definition of the SSA/P are described using the previous reports. Although the SSA/P is thought one of pre-cancerous lesions of the colorectal carcinoma, the decisive or documentary lesion like "carcinoma in adenoma" is very rare. In this review, the strict case of the carcinoma derived from the SSA/P is demonstrated using our cases. Although the genetic investigations of the SSA/P have shown the new pathway of colorectal carcinogenesis and these concepts are thought to be almost right, the verification for them should be performed using "the carcinoma in SSA/P" like the present case.
authors.affiliation: Division of Diagnostic Pathology, Juntendo University, Shizuoka Hospital, Izunokuni, 1129 Nagaoka, Izunokuni, Shizuoka, 410-2295, Japan, mdksmrwjunten522@ybb.ne.jp.
authors.forename: Ryo
authors.initials: R
authors.lastname: Wada
authors.forename: Toshio
authors.initials: T
authors.lastname: Morimoto
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Inayoshi
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000369:Aged, 80 and over; D000912:Antibodies, Neoplasm; D063646:Carcinogenesis / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology*; D006652:Histological Techniques; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011230:Precancerous Conditions / Q000473:pathology*
chemical_list: D000912:Antibodies, Neoplasm
references.citation: Hepatogastroenterology. 2011 Jul-Aug;58(109):1163-7
references.pmid: 21937375
references.citation: Am J Surg Pathol. 2003 Jan;27(1):65-81
references.pmid: 12502929
references.citation: Gut. 1998 May;42(5):680-4
references.pmid: 9659164
references.citation: Int J Cancer. 2011 Oct 15;129(8):1889-98
references.pmid: 21154739
references.citation: Nat Clin Pract Oncol. 2005 Aug;2(8):398-405
references.pmid: 16130936
references.citation: J Gastroenterol. 2013 Mar;48(3):287-302
references.pmid: 23208018
references.citation: Am J Surg Pathol. 2013 Jul;37(7):1039-43
references.pmid: 23648458
references.citation: Am J Clin Pathol. 2003 Jun;119(6):773-5
references.pmid: 12817423
references.citation: Am J Surg Pathol. 1990 Jun;14(6):524-37
references.pmid: 2186644
references.citation: Am J Gastroenterol. 2012 Aug;107(8):1213-9
references.pmid: 22688851
references.citation: Oncol Rep. 2005 Jul;14(1):121-7
references.pmid: 15944778
references.citation: Am J Surg Pathol. 2011 May;35(5):742-9
references.pmid: 21490447
references.citation: Am J Gastroenterol. 2012 Mar;107(3):460-9
references.pmid: 22233696
references.citation: Am J Surg Pathol. 2011 Sep;35(9):1274-86
references.pmid: 21836485
references.citation: J Clin Pathol. 2012 Oct;65(10):924-7
references.pmid: 22782936
references.citation: Dis Colon Rectum. 2002 Oct;45(10):1407-11
references.pmid: 12394444
references.citation: J Pathol. 2001 Mar;193(3):283-5
references.pmid: 11241405
references.citation: Am J Surg Pathol. 2008 Jan;32(1):21-9
references.pmid: 18162766
references.citation: Am J Surg Pathol. 2011 Feb;35(2):295-304
references.pmid: 21263251
references.citation: Dig Dis Sci. 1981 Jan;26(1):85-9
references.pmid: 7460710
references.citation: Pathol Int. 2004 Jun;54(6):401-7
references.pmid: 15144398
references.citation: Gastroenterology. 1974 Mar;66(3):347-56
references.pmid: 4813500
references.citation: World J Gastroenterol. 2012 Aug 28;18(32):4308-16
references.pmid: 22969193
references.citation: Histopathology. 2000 Oct;37(4):295-301
references.pmid: 11012735
references.citation: Oncol Rep. 2001 Jan-Feb;8(1):49-55
references.pmid: 11115568
references.citation: Diagn Pathol. 2012 May 29;7:59
references.pmid: 22642724
references.citation: Gastroenterol Clin North Am. 2007 Dec;36(4):947-68, viii
references.pmid: 17996799