title: Lysophosphatidic acid (LPA) signaling in human and ruminant reproductive tract.
abstract: Lysophosphatidic acid (LPA) through activating its G protein-coupled receptors (LPAR 1-6) exerts diverse cellular effects that in turn influence several physiological processes including reproductive function of the female. Studies in various species of animals and also in humans have identified important roles for the receptor-mediated LPA signaling in multiple aspects of human and animal reproductive tract function. These aspects range from ovarian and uterine function, estrous cycle regulation, early embryo development, embryo implantation, decidualization to pregnancy maintenance and parturition. LPA signaling can also have pathological consequences, influencing aspects of endometriosis and reproductive tissue associated tumors. The review describes recent progress in LPA signaling research relevant to human and ruminant reproduction, pointing at the cow as a relevant model to study LPA influence on the human reproductive performance.
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 Street, 10-747 Olsztyn, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Wocławek-Potocka
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 Street, 10-747 Olsztyn, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Rawińska
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 Street, 10-747 Olsztyn, Poland.
authors.forename: Ilona
authors.initials: I
authors.lastname: Kowalczyk-Zieba
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 Street, 10-747 Olsztyn, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Boruszewska
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 Street, 10-747 Olsztyn, Poland.
authors.forename: Emilia
authors.initials: E
authors.lastname: Sinderewicz
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medical Sciences, University of Warmia and Masuria, Zolnierska 14 C Street, 10-561 Olsztyn, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Waśniewski
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 Street, 10-747 Olsztyn, Poland.
authors.forename: Dariusz Jan
authors.initials: DJ
authors.lastname: Skarzynski
mesh_terms: D000818:Animals; D002417:Cattle; D004715:Endometriosis / Q000378:metabolism; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D005836:Genitalia, Female / Q000378:metabolism*; D006107:Granulosa Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008246:Lysophospholipids / Q000737:chemistry*; D006080:Ovarian Follicle / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D012418:Ruminants; D015398:Signal Transduction
chemical_list: D008246:Lysophospholipids; D043562:Receptors, G-Protein-Coupled; D005640:Follicle Stimulating Hormone; C032881:lysophosphatidic acid
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