title: UV-triggerable alginate beads decorated with basic proteinoid-coumarin conjugates.
abstract: UV-triggerable bead was prepared by coating the surface of alginate bead with a photo-responsive proteinoid. Epoxypropoxy coumarin (EPC) was covalently attached to a basic proteinoid composed of lysine and serine (PLS), and the PLS-EPC conjugate was used as a photo-responsive coat of the bead. EPC residues of PLS-EPC conjugate on the bead surface were photo-cross-linked upon the irradiation of λ = 365 nm, and then FITC-dextran was loaded as a fluorescence dye in the bead coated with photo-cross-linked PLS-EPC conjugate. Upon the irradiation of λ = 254 nm, the degree of release from the bead was enhanced possibly because the cross-linked network of PLS-EPC conjugate coating layer is photo-cleaved. The UV-triggerable bead developed in the present study could be applied to a UV-responsive drug carrier.
authors.affiliation: a Department of Medical Biomaterials Engineering , College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University , 192-1, Hyoja 2 dong, Chuncheon 200-701 , Kangwon-do , Korea.
authors.forename: Mi Kyoung
authors.initials: MK
authors.lastname: Kang
authors.forename: Jin-Chul
authors.initials: JC
authors.lastname: Kim
mesh_terms: D000464:Alginates / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry; D019281:Dimerization; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008863:Microspheres; D011506:Proteins / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D000464:Alginates; D003374:Coumarins; D003911:Dextrans; D004337:Drug Carriers; D006603:Hexuronic Acids; D011506:Proteins; C015219:fluorescein isothiocyanate dextran; D020723:Glucuronic Acid; C030123:coumarin; D016650:Fluorescein-5-isothiocyanate
keywords: UV-triggerable bead; epoxypropoxy coumarin; proteinoid