title: Mean platelet volume and uric acid levels in neonatal sepsis.
abstract: OBJECTIVE
  To determine the role of mean platelet volume (MPV) and uric acid levels in the diagnosis of neonatal sepsis (NS).
  
  
  METHODS
  A total of 146 newborns with suspected NS were prospectively included in the study and infants without NS (n = 142) were assigned as controls. The patients were divided into three groups: Group I (n = 64): clinical NS, Group II (n = 82): culture-proven NS, and Group III (n = 142): healthy controls.
  
  
  RESULTS
  The patients in Group II had the highest C-reactive protein (CRP) levels (54.6 ± 5.4 mg/L), lowest platelet counts (199,329 ± 135,952/mm(3)) and lowest uric acid levels (2.6 ± 1.8 mg/dL) when compared to Groups I and III (p < 0.05, for all comparisons). MPV values were higher in Group I (10.6 ± 1.1 fL) and Group II (10.4 ± 0.9 fL) when compared to Group III (9.2 ± 1.2 fL) (p = 0.001), although there was no difference between Groups I and II. Area under curve (AUC) values for CRP, MPV, and uric acid were 0.92 (p = 0.001), 0.76 (p = 0.001) and 0.28 (p = 0.001), respectively. The diagnostic cut-off values for CRP and MPV were 9.5 mg/dL and 10.4 fL. Sensitivity and specificity of MPV in NS were 54 % and 82 % respectively. When combined with CRP its sensitivity and specificity increased to 89 % and 79 % respectively.
  
  
  CONCLUSIONS
  The combined use of CRP and MPV should be considered in the early diagnosis of NS, but uric acid levels may only be utilized as an additional tool to support diagnosis. CRP is shown to be more sensitive and specific than MPV and uric acid in diagnosing neonatal sepsis.
authors.affiliation: Neonatal Intensive Care Unit, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Aydın
authors.forename: Dilek
authors.initials: D
authors.lastname: Dilli
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Zenciroğlu
authors.forename: Nilgün
authors.initials: N
authors.lastname: Karadağ
authors.forename: Serdar
authors.initials: S
authors.lastname: Beken
authors.forename: Nurullah
authors.initials: N
authors.lastname: Okumuş
mesh_terms: D001792:Blood Platelets; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
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