title: Use of immunohistochemical staining and electron microscopy to aid in diagnosis of soft tissue sarcomas associated with the fetlock joint in two horses.
abstract: Soft tissue sarcomas of the equine distal limb associated with joints, sheaths, or bursae have rarely been reported. Accurate diagnosis of these tumors is challenging in both human beings and veterinary species. Immunohistochemical staining and transmission electron microscopy have been used in human beings to reduce misdiagnosis. The current report describes 2 mature horses presenting with lameness and swelling associated with the dorsal aspect of the metacarpo(tarso)phalangeal joint. In both cases, surgical excision was performed with subsequent histological analysis of the masses to determine the tissue of origin. In both cases, immunohistochemical staining and transmission electron microscopy aided the definitive diagnosis of fibrosarcoma associated with the fetlock joints of 2 horses.
authors.affiliation: Clinical Sciences (Findley), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomInstitute for Aging and Chronic Disease (Singer, Milner), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomVeterinary Pathology (Leeming), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United Kingdom.
authors.forename: Judith A
authors.initials: JA
authors.lastname: Findley
authors.affiliation: Clinical Sciences (Findley), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomInstitute for Aging and Chronic Disease (Singer, Milner), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomVeterinary Pathology (Leeming), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United Kingdom.
authors.forename: Ellen R
authors.initials: ER
authors.lastname: Singer
authors.affiliation: Clinical Sciences (Findley), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomInstitute for Aging and Chronic Disease (Singer, Milner), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomVeterinary Pathology (Leeming), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United Kingdom.
authors.forename: Peter I
authors.initials: PI
authors.lastname: Milner
authors.affiliation: Clinical Sciences (Findley), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomInstitute for Aging and Chronic Disease (Singer, Milner), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomVeterinary Pathology (Leeming), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United Kingdom gail.leeming@liverpool.ac.uk.
authors.forename: Gail H
authors.initials: GH
authors.lastname: Leeming
keywords: Electron microscopy; equine; immunohistochemical staining; soft tissue sarcoma