title: Apoptosis-induced anti-tumor effect of Curcuma kwangsiensis polysaccharides against human nasopharyngeal carcinoma cells.
abstract: This study aimed to investigate the effect of Curcuma kwangsiensis polysaccharides on the viability of human nasopharyngeal carcinoma cell line CNE-2 cells, and explore the possible mechanisms. CNE-2 cells were treated with various concentrations of C. kwangsiensis polysaccharides, then the proliferation, apoptosis and the protein expression of apoptosis-related regulators p53 and Bcl-2 were assessed. The results demonstrated that C. kwangsiensis polysaccharides can significantly inhibit the proliferation of CNE-2 cells, which was possibly through the induction of apoptosis mediated by attenuating Bcl-2 expression and promoting p53 expression. The present study therefore indicates that C. kwangsiensis polysaccharides could be developed into potential drugs for nasopharyngeal carcinoma treatment.
authors.affiliation: School of Pharmaceutical, Guilin Medical University, Guilin, Guangxi 541004, China.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Zeng
authors.affiliation: School of Pharmaceutical, Guilin Medical University, Guilin, Guangxi 541004, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Dai
authors.affiliation: Department of Anesthesiology, Dongfeng Hospital Affiliated to Hubei University of Medicine, Shiyan, Hubei 441000, China.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Ren
authors.affiliation: College of Life Science, China West Normal University, Nanchong, Sichuan 637009, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Song
authors.affiliation: School of Pharmaceutical, Guilin Medical University, Guilin, Guangxi 541004, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Chen
authors.affiliation: School of Pharmaceutical, Guilin Medical University, Guilin, Guangxi 541004, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical, Guilin Medical University, Guilin, Guangxi 541004, China.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Huai'an First Hospital Affiliated to Nanjing Medical University, Huai'an, Jiangsu 223300, China.
authors.forename: Tiecheng
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Huai'an First Hospital Affiliated to Nanjing Medical University, Huai'an, Jiangsu 223300, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D002277:Carcinoma; D045744:Cell Line, Tumor; D030024:Curcuma / Q000737:chemistry*; D006801:Humans; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C000595707:BCL2 protein, human; D011134:Polysaccharides; D019253:Proto-Oncogene Proteins c-bcl-2; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53