title: Elevated mean platelet volume is associated with silent cerebral infarction.
abstract: BACKGROUND
  The presence of silent cerebral infarction (SCI) increases the risk of transient ischaemia attack, symptomatic stroke, cardiovascular disease and dementia. Mean platelet volume (MPV) is a surrogate marker of activated platelets and is considered a link between inflammation and thrombosis. In addition, MPV is a risk predictor for cardiovascular disease, stroke and overall vascular mortality.
  
  
  OBJECTIVE
  The purpose of the study was to assess the MPV levels in SCI patients.
  
  
  METHODS
  A cross-sectional study was conducted to evaluate the association between MPV and SCI in 2215 subjects (1385 men and 830 women).
  
  
  RESULTS
  The participants with SCI had higher MPV levels than those without SCI (10.4 ± 1.3 fL vs. 9.2 ± 1.2 fL; P < 0.001). Moreover, the subjects with a high MPV had a higher prevalence of SCI. Multivariate logistic regression analyses revealed that the odds ratios and 95% confidence intervals for SCI according to MPV quartiles were 1.000, 2.131 (1.319-3.444), 3.015 (1.896-4.794), 7.822 (4.874-12.554) respectively (P < 0.001).
  
  
  CONCLUSIONS
  MPV is a novel index for SCI regardless of classical cardiovascular risk factors.
authors.affiliation: Department of Neurology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: Z-G
authors.initials: ZG
authors.lastname: Cao
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: T-M
authors.initials: TM
authors.lastname: Liu
authors.forename: R-T
authors.initials: RT
authors.lastname: Wang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002544:Cerebral Infarction / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D063847:Mean Platelet Volume / Q000639:trends; D008875:Middle Aged
chemical_list: D015415:Biomarkers
keywords: atherosclerosis; mean platelet volume; platelet activation; risk factor; silent cerebral infarction