title: Hyperbaric oxygen, vasculogenic stem cells, and wound healing.
abstract: CONCLUSIONS
  Oxidative stress is recognized as playing a role in stem cell mobilization from peripheral sites and also cell function.
  
  
  BACKGROUND
  This review focuses on the impact of hyperoxia on vasculogenic stem cells and elements of wound healing.
  
  
  RESULTS
  Components of the wound-healing process in which oxidative stress has a positive impact on the various cells involved in wound healing are highlighted. A slightly different view of wound-healing physiology is adopted by departing from the often used notion of sequential stages: hemostatic, inflammatory, proliferative, and remodeling and instead organizes the cascade of wound healing as overlapping events or waves pertaining to reactive oxygen species, lactate, and nitric oxide. This was done because hyperoxia has effects of a number of cell signaling events that converge to influence cell recruitment/chemotaxis and gene regulation/protein synthesis responses which mediate wound healing.
  
  
  CONCLUSIONS
  Our alternative perspective of the stages of wound healing eases recognition of the multiple sites where oxidative stress has an impact on wound healing. This aids the focus on mechanistic events and the interplay among various cell types and biochemical processes. It also highlights the areas where additional research is needed.
authors.affiliation: 1 Department of Emergency Medicine, Institute for Environmental Medicine, University of Pennsylvania Medical Center , Philadelphia, Pennsylvania.
authors.forename: Katina M
authors.initials: KM
authors.lastname: Fosen
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Thom
mesh_terms: D000818:Animals; D006801:Humans; D006931:Hyperbaric Oxygenation; D019344:Lactic Acid / Q000378:metabolism; D018919:Neovascularization, Physiologic / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism; D010101:Oxygen Consumption; D017382:Reactive Oxygen Species / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D019344:Lactic Acid
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