title: Chronic kidney disease stage is a modulator on the association between high-sensitivity C-reactive protein and coronary vasospastic angina.
abstract: The prevalence of coronary vasospasm and also the factors associated with coronary vasospasm in CKD is still unclear. In this cross-sectional study of 859 consecutive CKD patients with angina pectoris received coronary catheterization, we evaluated the factors associated with coronary vasospasm. Patients with vasospasm were older and had higher peripheral blood white cell counts, higher peripheral blood monocyte cell counts, higher haemoglobin levels, higher hs-CRP levels, and lower levels of serum creatinine than patients without vasospasm. The results of multivariate logistic regression analysis revealed that peripheral blood monocyte count and hs-CRP level were independently associated with coronary vasospasm in patients with stage 1 CKD. Only peripheral blood monocyte count but not hs-CRP was independently associated with coronary vasospasm in patients with stages 2 and 3 of CKD. In conclusion, peripheral blood monocyte count is independently associated with coronary vasospasm in patients with stage 1-3 CKD, whereas hs-CRP is only independently associated with coronary vasospasm in patients with stage 1 CKD.
authors.affiliation: Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan ; The Graduate Institute of Clinical Medical Sciences, Chang Gung University Medical College, Taoyuan 33302, Taiwan ; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
authors.forename: Heng-Jung
authors.initials: HJ
authors.lastname: Hsu
authors.affiliation: Department of Pediatrics, Taipei Medical University Hospital, Taipei 11031, Taiwan.
authors.forename: Chiung-Hui
authors.initials: CH
authors.lastname: Yen
authors.affiliation: Laboratory of Epidemiology, Department of Health Care Management, Chang Gung University, Taoyuan 33302, Taiwan.
authors.forename: Kuang-Hung
authors.initials: KH
authors.lastname: Hsu
authors.affiliation: Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan ; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
authors.forename: I-Wen
authors.initials: IW
authors.lastname: Wu
authors.affiliation: Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan ; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
authors.forename: Chin-Chan
authors.identifier: 0000-0001-9128-2936
authors.initials: CC
authors.lastname: Lee
authors.affiliation: Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan ; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
authors.forename: Chiao-Yin
authors.initials: CY
authors.lastname: Sun
authors.affiliation: Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan ; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
authors.forename: Chia-Chi
authors.initials: CC
authors.lastname: Chou
authors.affiliation: Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan ; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
authors.forename: Chun-Yu
authors.initials: CY
authors.lastname: Chen
authors.affiliation: Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan ; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
authors.forename: Shih-Ying
authors.initials: SY
authors.lastname: Yang
authors.affiliation: Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan ; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
authors.forename: Chi-Jen
authors.initials: CJ
authors.lastname: Tsai
authors.affiliation: Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan ; The Graduate Institute of Clinical Medical Sciences, Chang Gung University Medical College, Taoyuan 33302, Taiwan ; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
authors.forename: Mai-Szu
authors.initials: MS
authors.lastname: Wu
authors.affiliation: The Graduate Institute of Clinical Medical Sciences, Chang Gung University Medical College, Taoyuan 33302, Taiwan ; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan ; Department of Cardiology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan.
authors.forename: Ming-Jui
authors.identifier: 0000-0003-4732-0450
authors.initials: MJ
authors.lastname: Hung
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D003324:Coronary Artery Disease / Q000378:metabolism*; D003329:Coronary Vasospasm / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D051436:Renal Insufficiency, Chronic / Q000378:metabolism*
chemical_list: D002097:C-Reactive Protein
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