title: A case of IgG4-related disease with bronchial asthma and chronic rhinosinusitis in Korea.
abstract: IgG4-related disease (IgG4-RD) is characterized by a systemic involvement of tumor-like lesions with IgG4-positive plasmacytes. We experienced a case of IgG4-RD developed in a patient with bronchial asthma (BA) and chronic rhinosinusitis (CRS). A 55-yr-old female patient with BA and CRS complained of both eyes and neck swelling as well as a recurrent upper respiratory infection in recent 1 yr. The serum levels of IgG4, creatinine, and pancreatic enzymes were elevated. A biopsy of the submandibular gland showed an abundant infiltration of IgG4-positive plasmacytes. Her symptoms remarkably improved after the treatment of a systemic steroid that has been maintained without recurrence. We report a rare case of IgG4-RD developed in a patient with BA and CRS.
authors.affiliation: Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Young-Soo
authors.identifier: 0000-0001-8918-9353
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Hyo-Jeong
authors.initials: HJ
authors.lastname: Cho
authors.affiliation: Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Hye-Soo
authors.initials: HS
authors.lastname: Yoo
authors.affiliation: Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Yoo-Sub
authors.initials: YS
authors.lastname: Shin
authors.affiliation: Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Hae-Sim
authors.identifier: 0000-0003-2614-0303
authors.initials: HS
authors.lastname: Park
mesh_terms: D001249:Asthma / Q000150:complications / Q000175:diagnosis*; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology; D010950:Plasma Cells / Q000502:physiology; D011239:Prednisolone / Q000627:therapeutic use; D056910:Republic of Korea; D012220:Rhinitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D012852:Sinusitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D013363:Submandibular Gland / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D007074:Immunoglobulin G; D011239:Prednisolone; D003404:Creatinine
keywords: Asthma; Bronchitis, Chronic; IgG4-Related Disease
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