title: Chemical constituents and their antibacterial and antifungal activity from the Egyptian herbal medicine Chiliadenus montanus.
abstract: Phytochemical investigations of the CH2Cl2/MeOH (1:1) extract of air-dried aerial parts of Chiliadenus montanus afforded eight metabolites, in addition to eight other previously reported compounds, of which two were isolated for the first time as free acids. Structures were established by spectroscopic methods, including HREIMS, (1)H, (13)C, DEPT, (1)H-(1)H COSY, HMQC and HMBC NMR analysis. Antimicrobial activity against an array of common bacterial and fungal strains was measured via a colorimetric assay with minimal growth inhibition observed in the μg/mL range for one of the tested metabolites.
authors.affiliation: Chemistry of Medicinal Plants Department, and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir St., Dokki, Giza 12622, Egypt.
authors.forename: Mohamed-Elamir F
authors.initials: MF
authors.lastname: Hegazy
authors.affiliation: Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.affiliation: Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Delta University for Science and Technology, Pharmacognosy Department, Faculty of Pharmacy, Gamasa, Egypt.
authors.forename: Taha A
authors.initials: TA
authors.lastname: Hussein
authors.affiliation: Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA. Electronic address: paul.pare@ttu.edu.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Paré
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D029001:Herbal Medicine; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents
keywords: Antimicrobial activity; Asteraceae; Chiliadenus montanus; Dioxane; Flavonoids; Sesquiterpenes