title: Isolated IgA anti- β2 glycoprotein I antibodies in patients with clinical criteria for antiphospholipid syndrome.
abstract: Seronegative antiphospholipid syndrome (SNAPS) is an autoimmune disease present in patients with clinical manifestations highly suggestive of Antiphospholipid Syndrome (APS) but with persistently negative consensus antiphospholipid antibodies (a-PL). IgA anti-β 2 Glycoprotein I (aB2-GPI) antibodies are associated with APS. However, they are not currently considered to be laboratory criteria due to the heterogeneity of published works and the use of poor standardized diagnostic systems. We have aimed to assess aPL antibodies in a group of patients with clinical manifestations of APS (C-APS) to evaluate the importance of the presence of IgA aB2GPI antibodies in APS and its relation with other aPL antibodies. Only 14% of patients with C-APS were positive for any consensus antibody, whereas the presence of isolated IgA aB2GPI antibodies was found in 22% of C-APS patients. In patients with arterial thrombosis IgA aB2GPI, antibodies were the only aPL antibodies present. Serologic profile in primary APS (PAPS) is different from systemic autoimmune disorders associated APS (SAD-APS). IgA aB2GPI antibodies are more prevalent in PAPS and IgG aB2GPI antibodies are predominant in SAD-APS. The analysis of IgA aB2GPI antibodies in patients with clinical manifestations of PAPS might avoid underdiagnosed patients and provide a better diagnosis in patients with SAD-APS. Laboratory consensus criteria might consider including analysis of IgA aB2GPI for APS diagnosis.
authors.affiliation: Servicio de Inmunología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Ruiz-García
authors.affiliation: Servicio de Nefrología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Serrano
authors.affiliation: Servicio de Inmunología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, Spain.
authors.forename: José Ángel
authors.initials: JÁ
authors.lastname: Martínez-Flores
authors.affiliation: Servicio de Inmunología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Mora
authors.affiliation: Servicio de Reumatología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Morillas
authors.affiliation: Servicio de Hematología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, Spain.
authors.forename: María Ángeles
authors.initials: MÁ
authors.lastname: Martín-Mola
authors.affiliation: Servicio de Nefrología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Morales
authors.affiliation: Servicio de Inmunología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, Spain ; Sección de Inmunología, Universidad San Pablo-CEU, Campus de Monteprincipe, 28668 Madrid, Spain.
authors.forename: Estela
authors.initials: E
authors.lastname: Paz-Artal
authors.affiliation: Servicio de Inmunología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, Spain ; Sección de Inmunología, Universidad San Pablo-CEU, Campus de Monteprincipe, 28668 Madrid, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Serrano
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000097:blood* / Q000150:complications / Q000276:immunology / Q000473:pathology; D002341:Carotid Artery Thrombosis / Q000097:blood* / Q000150:complications / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020246:Venous Thrombosis / Q000097:blood* / Q000150:complications / Q000276:immunology / Q000473:pathology; D053482:beta 2-Glycoprotein I / Q000037:antagonists & inhibitors / Q000097:blood*
chemical_list: D017152:Antibodies, Antiphospholipid; D007070:Immunoglobulin A; D053482:beta 2-Glycoprotein I
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