title: Yttrium-90 radioembolization vs sorafenib for intermediate-locally advanced hepatocellular carcinoma: a cohort study with propensity score analysis.
abstract: OBJECTIVE
  Sorafenib and transarterial (90) Y-radioembolization (TARE) are possible treatments for Barcelona Clinic Liver Cancer (BCLC) intermediate-advanced stage hepatocellular carcinoma (HCC). No study directly comparing sorafenib and TARE is currently available. This single-centre retrospective study compares the outcomes achieved with sorafenib and TARE in HCC patients potentially amenable to either therapy.
  
  
  METHODS
  Seventy-four sorafenib (71 ± 10 years, male 87%, BCLC B/C 53%/47%) and 63 TARE HCC patients (66 ± 9 years, male 79%, BCLC B/C 41%/59%) were included based on the following criteria: Child-Pugh class A/B, performance status ≤1, HCC unfit for other effective therapies, no metastases and no previous systemic chemotherapy.
  
  
  RESULTS
  Median overall survivals of the two groups were comparable, being 14.4 months (95% CI: 4.3-24.5) in sorafenib and 13.2 months (95% CI: 6.1-20.2) in TARE patients, with 1-, 2- and 3-year survival rates of 52.1%, 29.3% and 14.7% vs 51.8%, 27.8% and 21.6% respectively. Two TARE patients underwent liver transplantation after successful down-staging. To minimize the impact of confounding factors on survival analysis, propensity model matched 32 patients of each group for median age, tumour gross pathology and the independent prognostic factors (portal vein thrombosis, performance status, Model for End Liver Disease). Even after matching, the median survival did not differ between sorafenib (13.1 months; 95% CI: 1.2-25.9) and TARE patients (11.2 months; 95% CI: 6.7-15.7), with comparable 1-, 2- and 3-year survival rates.
  
  
  CONCLUSIONS
  In cirrhotic patients with intermediate-advanced or not-otherwise-treatable HCC, sorafenib and TARE provide similar survivals. Down-staging allowing liver transplantation only occurred after TARE.
authors.affiliation: Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
authors.forename: Annagiulia
authors.initials: A
authors.lastname: Gramenzi
authors.forename: Rita
authors.initials: R
authors.lastname: Golfieri
authors.forename: Cristina
authors.initials: C
authors.lastname: Mosconi
authors.forename: Alberta
authors.initials: A
authors.lastname: Cappelli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Granito
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cucchetti
authors.forename: Sara
authors.initials: S
authors.lastname: Marinelli
authors.forename: Cinzia
authors.initials: C
authors.lastname: Pettinato
authors.forename: Virginia
authors.initials: V
authors.lastname: Erroi
authors.forename: Silvia
authors.initials: S
authors.lastname: Fiumana
authors.forename: Luigi
authors.initials: L
authors.lastname: Bolondi
authors.forename: Mauro
authors.initials: M
authors.lastname: Bernardi
authors.forename: Franco
authors.initials: F
authors.lastname: Trevisani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000628:therapy*; D016022:Case-Control Studies; D002423:Cause of Death; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008113:Liver Neoplasms / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010671:Phenylurea Compounds / Q000627:therapeutic use*; D057216:Propensity Score; D012189:Retrospective Studies; D000077157:Sorafenib; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D015021:Yttrium Radioisotopes; D009536:Niacinamide; D000077157:Sorafenib
keywords: advanced stage; primary liver cancer; sorafenib; transarterial radiotherapy; treatment