title: [A case of adrenal metastasectomy in renal cell carcinoma after neoadjuvant therapy with sunitinib].
abstract: A 58-year-old man had undergone laparoscopic radical nephrectomy for right renal cell carcinoma. The histopathological diagnosis was clear cell carcinoma, grade 2＞3, pT1b. Two years and 10 months postoperatively, computed tomography scans demonstrated an enhanced mass on the right adrenal gland. As we could not detect other metastatic lesions, it was diagnosed as solitary adrenal metastasis of renal cell carcinoma. Albeit metastasectomy was planned with curative intent, right hemihepatectomy was also required for surgical removal because the tumor was adherent to the right lobe of the liver broadly and had indistinct margins. So we started neoadjuvant therapy with sunitinib. Eight courses of treatment shrunk the metastatic tumor enough to allow it to be removed completely without partial hepatectomy. Neoadjuvant therapy with the molecular targeted drugs may provide an effective option for metastasectomy in renal cell carcinoma regarding increased curability and decreased the risk of an operation.
authors.affiliation: The Department of Urology, Tenri Hospital.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hamada
authors.affiliation: The Department of Urology, Tenri Hospital.
authors.forename: Takuro
authors.initials: T
authors.lastname: Sunada
authors.affiliation: The Department of Urology, Tenri Hospital.
authors.forename: Keiji
authors.initials: K
authors.lastname: Kato
authors.affiliation: The Department of Urology, Tenri Hospital.
authors.forename: Atsuro
authors.initials: A
authors.lastname: Sawada
authors.affiliation: The Department of Urology, Tenri Hospital.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawanishi
authors.affiliation: The Department of Urology, Tenri Hospital.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okumura
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000556:secondary* / Q000628:therapy*; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D011758:Pyrroles / Q000627:therapeutic use*; D000077210:Sunitinib
chemical_list: D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib