title: Suffrutines A and B: a pair of Z/E isomeric indolizidine alkaloids from the roots of Flueggea suffruticosa.
abstract: Suffrutines A (1) and B (2), a pair of novel photochemical Z/E isomeric indolizidine alkaloids, with a unique and highly conjugated C20 skeleton, were isolated from the roots of Flueggea suffruticosa. The structures were elucidated by extensive analysis of NMR spectra and single-crystal X-ray diffraction. The light-induced isomerization and hypothetical biogenetic pathway to 1 and 2, as well as their activity for regulating the morphology of Neuro-2a cells are also discussed.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, 510632 Guangzhou (China); JNU-HKUST Joint Laboratory for Neuroscience & Innovation Drug Research, Jinan University, 510632 Guangzhou (China).
authors.forename: Zhen-Long
authors.initials: ZL
authors.lastname: Wu
authors.forename: Bing-Xin
authors.initials: BX
authors.lastname: Zhao
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Gen-Yun
authors.initials: GY
authors.lastname: Tang
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Ren-Wang
authors.initials: RW
authors.lastname: Jiang
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D054836:Indolizidines / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D001688:Biological Products; D004365:Drugs, Chinese Herbal; D054836:Indolizidines
keywords: NMR spectroscopy; alkaloids; natural products; photochemistry; structure elucidation