title: Brain tumor risk according to germ-line variation in the MLLT10 locus.
abstract: Genome-wide association studies have recently identified a cancer susceptibility locus at 10p12 mapping to MLLT10 associated with the onset of diverse tumors. We genotyped two tightly linked single-nucleotide polymorphisms (SNPs) at MLLT10 associated with meningioma (rs12770228) or ovarian cancer (rs1243180), and tested for associations among 295 meningioma cases, 606 glioma cases and 646 noncancer controls, all of European descent. The variant 'A' allele in MLLT10 rs12770228 was associated with an increased risk of meningioma (per allele odds ratio: 1.25; 95% confidence interval: 1.02, 1.53; P=0.031). Similar associations were observed for rs1243180. MLLT10 variants were unrelated to glioma. Functional investigation identified 22 candidate functional SNPs mapping to this region. The present study further validates 10p12 as a meningioma risk locus.
authors.affiliation: Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Egan
authors.affiliation: Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: Rebekah
authors.initials: R
authors.lastname: Baskin
authors.affiliation: Neuro-oncology Program, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: L Burton
authors.initials: LB
authors.lastname: Nabors
authors.affiliation: Department of Neurosurgery, Emory School of Medicine, Atlanta, GA, USA.
authors.forename: Reid C
authors.initials: RC
authors.lastname: Thompson
authors.affiliation: Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Olson
authors.affiliation: Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Browning
authors.affiliation: Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: Melissa H
authors.initials: MH
authors.lastname: Madden
authors.affiliation: Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: Alvaro N
authors.initials: AN
authors.lastname: Monteiro
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001932:Brain Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D005854:Germ Cells / Q000378:metabolism*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C092513:MLLT10 protein, human; D014157:Transcription Factors
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