title: A Randomized Controlled Trial to Study the Effect of Yoga Therapy on Cardiac Function and N Terminal Pro BNP in Heart Failure.
abstract: OBJECTIVE
  The purpose of this study was to evaluate whether yoga training in addition to standard medical therapy can improve cardiac function and reduce N terminal pro B-type natriuretic peptide (NT pro BNP) in heart failure (HF).
  
  
  METHODS
  130 patients were recruited and randomized into two groups: Control Group (CG) (n = 65), Yoga Group (YG). In YG, 44 patients and in CG, 48 patients completed the study. Cardiac function using left ventricular ejection fraction (LVEF), myocardial performance index (Tei index), and NT pro BNP, a biomarker of HF, was assessed at baseline and after 12 weeks.
  
  
  RESULTS
  Improvement in LVEF, Tei index, and NT pro BNP were statistically significant in both the groups. Furthermore, when the changes in before and after 12 weeks were in percentage, LVEF increased 36.88% in the YG and 16.9% in the CG, Tei index was reduced 27.87% in the YG and 2.79% in the CG, NT pro BNP was reduced 63.75% in the YG and 10.77% in the CG. The between group comparisons from pre to post 12 weeks were significant for YG improvements (LVEF, P < 0.01, Tei index, P < 0.01, NT pro BNP, P < 0.01).
  
  
  CONCLUSIONS
  These results indicate that the addition of yoga therapy to standard medical therapy for HF patients has a markedly better effect on cardiac function and reduced myocardial stress measured using NT pro BNP in patients with stable HF.
authors.affiliation: Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
authors.forename: Bandi Hari
authors.initials: BH
authors.lastname: Krishna
authors.affiliation: Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
authors.forename: Pravati
authors.initials: P
authors.lastname: Pal
authors.affiliation: Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India. ; Advanced Centre for Yoga Therapy Education and Research (ACYTER), JIPMER, Puducherry, India.
authors.forename: Gk
authors.initials: G
authors.lastname: Pal
authors.affiliation: Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
authors.forename: J
authors.initials: J
authors.lastname: Balachander
authors.affiliation: Advanced Centre for Yoga Therapy Education and Research (ACYTER), JIPMER, Puducherry, India.
authors.forename: E
authors.initials: E
authors.lastname: Jayasettiaseelon
authors.affiliation: Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
authors.forename: Y
authors.initials: Y
authors.lastname: Sreekanth
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
authors.forename: Mg
authors.initials: M
authors.lastname: Sridhar
authors.affiliation: Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
authors.forename: Gs
authors.initials: G
authors.lastname: Gaur
keywords: NT pro BNP; Tei index; ejection fraction; heart failure; yoga therapy
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