title: N-Acyl amino acids and their impact on biological processes.
abstract: Over the last two decades a large number of N-long-chain acyl amino acids have been identified in the mammalian body. The pharmacological activities of only a few of them have been investigated and some have been found to be of considerable interest. Thus arachidonoyl serine is vasodilatory and neuroprotective, arachidonoyl glycine is antinociceptive, and oleoyl serine rescues bone loss. However, the pathophysiological/biochemical roles of these amides are mostly unknown.
authors.affiliation: Institute for Drug Research, Hebrew University Medical Faculty, Jerusalem, 91120, Israel.
authors.forename: Lumír
authors.initials: L
authors.lastname: Hanuš
authors.forename: Esther
authors.initials: E
authors.lastname: Shohami
authors.forename: Itai
authors.initials: I
authors.lastname: Bab
authors.forename: Raphael
authors.initials: R
authors.lastname: Mechoulam
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000502:physiology*; D004032:Diet; D005998:Glycine / Q000031:analogs & derivatives* / Q000502:physiology; D006801:Humans; D009752:Nutritional Status; D009829:Oleic Acids / Q000502:physiology*; D012694:Serine / Q000031:analogs & derivatives* / Q000502:physiology; D013654:Taurine / Q000031:analogs & derivatives* / Q000502:physiology*
chemical_list: D001095:Arachidonic Acids; C509235:N-arachidonoyl L-serine; C465623:N-arachidonylglycine; D009829:Oleic Acids; D013654:Taurine; D012694:Serine; D005998:Glycine
keywords: N-acyl taurines; N-arachidonoyl glycine; N-arachidonoyl serine; N-oleoyl serine; osteoporosis; traumatic brain injury