title: A case report of deferasirox-induced kidney injury and Fanconi syndrome.
abstract: Cases of kidney injury associated with the use of deferasirox chelation therapy during the course of treatment for iron overload have been reported infrequently. We present the case of a patient treated with deferasirox who had biopsy-proven tubular injury in the setting of clinical Fanconi syndrome. The patient required hospitalization for metabolic acidosis, electrolyte abnormalities, and associated symptoms. With supportive care and cessation of chelation therapy he improved, but has yet to fully recover. This is the first known case reporting biopsy-proven tubular damage in the setting of deferasirox use.
authors.forename: Noreen
authors.initials: N
authors.lastname: Murphy
authors.forename: Mohsen
authors.initials: M
authors.lastname: Elramah
authors.forename: Hemender
authors.initials: H
authors.lastname: Vats
authors.forename: Weixong
authors.initials: W
authors.lastname: Zhong
authors.forename: Micah R
authors.initials: MR
authors.lastname: Chan
mesh_terms: D001565:Benzoates / Q000009:adverse effects*; D000077588:Deferasirox; D005198:Fanconi Syndrome / Q000139:chemically induced*; D006801:Humans; D007502:Iron Chelating Agents / Q000009:adverse effects*; D019190:Iron Overload / Q000188:drug therapy*; D008297:Male; D051437:Renal Insufficiency / Q000139:chemically induced*; D014230:Triazoles / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D001565:Benzoates; D007502:Iron Chelating Agents; D014230:Triazoles; D000077588:Deferasirox