title: Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism.
abstract: BACKGROUND
  We investigated whether genetic variations robustly associated with coronary artery disease are also associated with risk of venous thromboembolism in a well-defined, female case-control study (n=2753) from Sweden.
  
  
  METHODS
  39 single nucleotide polymorphisms in 32 loci associated with coronary artery disease in genome-wide association studies were identified in a literature search and genotyped in the ThromboEmbolism Hormone Study (TEHS). Association with venous thromboembolism was assessed by logistic regression.
  
  
  RESULTS
  Only rs579459 in the ABO locus demonstrated a significant association with VTE. A tentative association between ANRIL and VTE in the discovery analysis failed to replicate in a meta-analysis of 4 independent cohorts (total n=7181).
  
  
  CONCLUSIONS
  It appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE.
authors.affiliation: Coagulation Unit, Hematology Centre, Karolinska University Hospital Solna, Sweden; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Bruzelius
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. Electronic address: rona.strawbridge@ki.se.
authors.forename: Rona J
authors.initials: RJ
authors.lastname: Strawbridge
authors.affiliation: INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, F-75013, Paris, France; ICAN Institute for Cardiometabolism and Nutrition, F-75013, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, F-75013, Paris, France.
authors.forename: David-Alexandre
authors.initials: DA
authors.lastname: Trégouët
authors.affiliation: Department of Medicine, University of Washington, Seattle WA USA.
authors.forename: Kerri L
authors.initials: KL
authors.lastname: Wiggins
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Karl
authors.initials: K
authors.lastname: Gertow
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Sabater-Lleal
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
authors.forename: John
authors.initials: J
authors.lastname: Öhrvik
authors.affiliation: Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Annica
authors.initials: A
authors.lastname: Bergendal
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Angela
authors.initials: A
authors.lastname: Silveira
authors.affiliation: Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Sundström
authors.affiliation: Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Helle
authors.initials: H
authors.lastname: Kieler
authors.affiliation: Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Syvänen
authors.affiliation: Department of Epidemiology, University of Washington, Seattle WA USA; Group Health Research Institute, Group Health Cooperative, Seattle WA USA; Seattle Epidemiologic Research and Information Center, Veterans Affairs Office of Research and Development, Seattle WA 98101, USA.
authors.forename: Nicholas L
authors.initials: NL
authors.lastname: Smith
authors.affiliation: Inserm UMR 1062, Marseille, Aix-Marseille Université, Marseille, France.
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Morange
authors.affiliation: Coagulation Unit, Hematology Centre, Karolinska University Hospital Solna, Sweden; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Science for Life Laboratory Stockholm, Department of Proteomics, School of Biotechnology, KTH, Solna, Sweden.
authors.forename: Jacob
authors.initials: J
authors.lastname: Odeberg
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Hamsten
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding / Q000235:genetics; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000235:genetics*; D055815:Young Adult
chemical_list: D000017:ABO Blood-Group System; C561518:CDKN2B antisense RNA, human; D062085:RNA, Long Noncoding
keywords: ABO; ANRIL; Coronary artery disease; Genetics; Venous thromboembolism