title: Glycemic control indicators in patients with neonatal diabetes mellitus.
abstract: Neonatal diabetes mellitus (NDM) is a type of diabetes mellitus caused by genetic abnormality which develops in insulin dependent state within 6 mo after birth. HbA1c is widely used in clinical practice for diabetes mellitus as the gold standard glycemic control indicator; however, fetal hemoglobin (HbF) is the main hemoglobin in neonates and so HbA1c cannot be used as a glycemic control indicator in NDM. Glycated albumin (GA), another glycemic control indicator, is not affected by HbF. We reported that GA can be used as a glycemic control indicator in NDM. However, it was later found that because of increased metabolism of albumin, GA shows an apparently lower level in relation to plasma glucose in NDM; measures to solve this problem were needed. In this review, we outlined the most recent findings concerning glycemic control indicators in neonates or NDM.
authors.affiliation: Shigeru Suzuki, Department of Pediatrics, Asahikawa Medical University, Asahikawa 078-8510, Hokkaido, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Shigeru Suzuki, Department of Pediatrics, Asahikawa Medical University, Asahikawa 078-8510, Hokkaido, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Koga
keywords: 1,5-anhydroglucitol; Fructosamine; Glycated albumin; Glycemic control; HbA1c; Neonatal diabetes mellitus
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