title: Interpretation of coagulation test results under direct oral anticoagulants.
abstract: Diagnostic of global coagulation parameters is part of the daily clinical routine practice in conservative as well in operative disciplines. The correct interpretation of in vitro test results in context to the ex vivo influence of anticoagulant drugs and the in vivo hemostatic system of the individual patient is dependent on the doctors clinical and laboratory experience. This article shortly reviews the laboratory interference of oral anticoagulants including the target-specific inhibitors dabigatran, rivaroxaban and apixaban on coagulation parameters and discusses the potential of several methods for measuring the anticoagulant effect of the direct oral anticoagulants.
authors.affiliation: Department of Internal Medicine, Division of Vascular Medicine, Johann Wolfgang Goethe-University Hospital Frankfurt/Main, Frankfurt, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Mani
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D001780:Blood Coagulation Tests; D006801:Humans; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants
keywords: Anticoagulants; apixaban; dabigatran; laboratory; rivaroxaban; warfarin