title: Concise review: mesenchymal stromal cells used for periodontal regeneration: a systematic review.
abstract: Periodontitis is a chronic infectious disease of the soft and hard tissues supporting the teeth. Recent advances in regenerative medicine and stem cell biology have paved the way for periodontal tissue engineering. Mesenchymal stromal cells (MSCs) delivered in situ to periodontal defects may exert their effects at multiple levels, including neovascularization, immunomodulation, and tissue regeneration. This systematic review had two goals: (a) to objectively quantify key elements for efficacy and safety of MSCs used for periodontal regeneration and (b) to identify patterns in the existing literature to explain differences between studies and suggest recommendations for future research. This systematic review provided good evidence of the capacity of MSCs to regenerate periodontal tissues in animals; however, experimentally generated defects used in animal studies do not sufficiently mimic the pathophysiology of periodontitis in humans. Moreover, the safety of such interventions in humans still needs to be studied. There were marked differences between experimental and control groups that may be influenced by characteristics that are crucial to address before translation to human clinical trials. We suggest that the appropriate combination of cell source, carrier type, and biomolecules, as well as the inclusion of critical path issues for a given clinical case, should be further explored and refined before transitioning to clinical trials. Future studies should investigate periodontal regenerative procedures in animal models, including rodents, in which the defects generated are designed to more accurately reflect the inflammatory status of the host and the shift in their pathogenic microflora.
authors.affiliation: STROMALab, Toulouse, France; Université de Toulouse, Toulouse, France; INSERM, Toulouse, France; Etablissement Français du Sang Pyrénées-Méditerranée, Toulouse, France; Departments of Public Health and Biology, Toulouse Faculty of Dentistry, Paul Sabatier University and Toulouse University Hospital, CHU de Toulouse, Toulouse, France; Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Monsarrat
authors.affiliation: STROMALab, Toulouse, France; Université de Toulouse, Toulouse, France; INSERM, Toulouse, France; Etablissement Français du Sang Pyrénées-Méditerranée, Toulouse, France; Departments of Public Health and Biology, Toulouse Faculty of Dentistry, Paul Sabatier University and Toulouse University Hospital, CHU de Toulouse, Toulouse, France; Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California, USA.
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Vergnes
authors.affiliation: STROMALab, Toulouse, France; Université de Toulouse, Toulouse, France; INSERM, Toulouse, France; Etablissement Français du Sang Pyrénées-Méditerranée, Toulouse, France; Departments of Public Health and Biology, Toulouse Faculty of Dentistry, Paul Sabatier University and Toulouse University Hospital, CHU de Toulouse, Toulouse, France; Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California, USA.
authors.forename: Cathy
authors.initials: C
authors.lastname: Nabet
authors.affiliation: STROMALab, Toulouse, France; Université de Toulouse, Toulouse, France; INSERM, Toulouse, France; Etablissement Français du Sang Pyrénées-Méditerranée, Toulouse, France; Departments of Public Health and Biology, Toulouse Faculty of Dentistry, Paul Sabatier University and Toulouse University Hospital, CHU de Toulouse, Toulouse, France; Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California, USA.
authors.forename: Michel
authors.initials: M
authors.lastname: Sixou
authors.affiliation: STROMALab, Toulouse, France; Université de Toulouse, Toulouse, France; INSERM, Toulouse, France; Etablissement Français du Sang Pyrénées-Méditerranée, Toulouse, France; Departments of Public Health and Biology, Toulouse Faculty of Dentistry, Paul Sabatier University and Toulouse University Hospital, CHU de Toulouse, Toulouse, France; Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California, USA.
authors.forename: Malcolm L
authors.initials: ML
authors.lastname: Snead
authors.affiliation: STROMALab, Toulouse, France; Université de Toulouse, Toulouse, France; INSERM, Toulouse, France; Etablissement Français du Sang Pyrénées-Méditerranée, Toulouse, France; Departments of Public Health and Biology, Toulouse Faculty of Dentistry, Paul Sabatier University and Toulouse University Hospital, CHU de Toulouse, Toulouse, France; Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California, USA.
authors.forename: Valérie
authors.initials: V
authors.lastname: Planat-Bénard
authors.affiliation: STROMALab, Toulouse, France; Université de Toulouse, Toulouse, France; INSERM, Toulouse, France; Etablissement Français du Sang Pyrénées-Méditerranée, Toulouse, France; Departments of Public Health and Biology, Toulouse Faculty of Dentistry, Paul Sabatier University and Toulouse University Hospital, CHU de Toulouse, Toulouse, France; Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California, USA.
authors.forename: Louis
authors.initials: L
authors.lastname: Casteilla
authors.affiliation: STROMALab, Toulouse, France; Université de Toulouse, Toulouse, France; INSERM, Toulouse, France; Etablissement Français du Sang Pyrénées-Méditerranée, Toulouse, France; Departments of Public Health and Biology, Toulouse Faculty of Dentistry, Paul Sabatier University and Toulouse University Hospital, CHU de Toulouse, Toulouse, France; Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California, USA philippe.kemoun@univ-tlse3.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Kémoun
mesh_terms: D000818:Animals; D019317:Evidence-Based Medicine; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects; D010518:Periodontitis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D010519:Periodontium / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D016896:Treatment Outcome
keywords: Mesenchymal stromal cells; Periodontal diseases; Review; Stem cells; Systematic; Tissue engineering
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