title: C-reactive protein and bacterial infection in cirrhosis.
abstract: In the general population, C-reactive protein (CRP) level increases in the presence of acute or chronic inflammation and infections. In patients with cirrhosis, the basal level is higher than in patients without cirrhosis, due to chronic hepatic and other inflammation, but when infection occurs the more severe the underlying liver dysfunction, the lower the increase in CRP. Therefore, the predictive power of CRP for infection and prognosis is weak in patients with decompensated/advanced cirrhosis and in the intensive care setting. However, higher CRP and also persistently elevated CRP levels can help identify patients with a higher short-term risk of mortality.
authors.affiliation: The Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital, Royal Free Hamsptead NHS Trust and Institute of Liver and Digestive Health, University College London (Giulia Pieri, Andrew K. Burroughs).
authors.forename: Giulia
authors.initials: G
authors.lastname: Pieri
authors.affiliation: Critical Care Medicine, Royal Free London NHS Foundation Trust (Agarwal Banwari), London, United Kingdom.
authors.forename: Banwari
authors.initials: B
authors.lastname: Agarwal
authors.affiliation: The Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital, Royal Free Hamsptead NHS Trust and Institute of Liver and Digestive Health, University College London (Giulia Pieri, Andrew K. Burroughs).
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Burroughs
keywords: C-reactive protein; Intensive Care Unit; bacterial infections; cirrhosis; mortality; prognosis
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