title: Results of the 4th scientific workshop of the ECCO (I): pathophysiology of intestinal fibrosis in IBD.
abstract: The fourth scientific workshop of the European Crohn's and Colitis Organization (ECCO) focused on the relevance of intestinal fibrosis in the disease course of inflammatory bowel disease (IBD). The objective was to better understand the pathophysiological mechanisms of intestinal fibrosis, to identify useful markers and imaging modalities of fibrosis in order to assess its presence and progression, and, finally, to point out possible approaches for the prevention and the treatment of fibrosis. The results of this workshop are presented in three separate manuscripts. This first section describes the most important mechanisms that contribute to the initiation and progression of intestinal fibrosis in IBD including the cellular and molecular mediators, the extracellular matrix molecules and matrix metalloproteinases/tissue inhibitors of metalloproteinases-system, the microbiota products, the role of fat, genetic and epigenetic factors, as well as the currently available experimental models. Furthermore, it identifies unanswered questions in the field of intestinal fibrosis and provides a framework for future research.
authors.affiliation: Department of Life, Health and Environmental Sciences, Gastroenterology Unit, University of L'Aquila, L'Aquila, Italy. Electronic address: giolatel@tin.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Latella
authors.affiliation: Division of Gastroenterology and Hepatology, University Hopsital of Zurich, Zurich, Switzerland.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Rogler
authors.affiliation: Academic Department of Gastroenterology, Ethnikon and Kapodistriakon University of Athens, Laikon Hospital, Athens, Greece.
authors.forename: Giorgos
authors.initials: G
authors.lastname: Bamias
authors.affiliation: Department of Immunology and Microbiology, Laboratory of Clinical Immunology, KU Leuven, Leuven, Belgium; Department of Clinical and Experimental Medicine, Translational Research in Gastrointestinal Disorders, KU Leuven, Leuven, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Breynaert
authors.affiliation: Research Group of Gastroenterology and Nutrition, Institute of Clinical Medicine, Artic University of Norway and University Hospital of Northern Norway, Tromsø, Norway.
authors.forename: Jon
authors.initials: J
authors.lastname: Florholmen
authors.affiliation: General Surgery Unit, Second University of Naples, Naples, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Pellino
authors.affiliation: Department of Pediatrics, Hadassah Medical Center, Jerusalem, Israel.
authors.forename: Shimon
authors.initials: S
authors.lastname: Reif
authors.affiliation: National Institute of Health and Medical Research-INSERM, Unit U995, Lille, France.
authors.forename: Silvia
authors.initials: S
authors.lastname: Speca
authors.affiliation: Centre for Inflammatory Bowel Diseases, Fremantle Hospital, WA, Australia; University Department of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, WA, Australia.
authors.forename: Ian C
authors.initials: IC
authors.lastname: Lawrance
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism*; D005355:Fibrosis; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology / Q000473:pathology*; D020782:Matrix Metalloproteinases / Q000378:metabolism; D064307:Microbiota; D015398:Signal Transduction; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism
chemical_list: D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases
keywords: Crohn's disease; Genetics; Inflammatory bowel disease; Intestinal fibrosis; Microbiota; Ulcerative colitis