title: Cornu cervi pantotrichum supplementation improves exercise performance and protects against physical fatigue in mice.
abstract: Cornu cervi pantotrichum (CCP) is a well-known yang-invigorating agent used in traditional Chinese medicine that can nourish the blood, tonify qi, and invigorate bones and tendons with multifunctional bioactivities. However, evidence on the effects of CCP on exercise performance and physical fatigue is limited. We evaluated the potential beneficial effects of ethanolic extract from CCP on ergogenic and antifatigue functions following a physiological challenge. Male ICR mice from four groups (n=8 per group) were orally administered CCP for 14 days at 0, 2054, and 4108 mg/kg/day, and were respectively designated as the vehicle, CCP-1X, and CCP-2X groups. The physical performance and antifatigue function were evaluated using forelimb grip strength and exhaustive swimming time as well as serum levels of lactate, ammonia, glucose, and creatine kinase after a 15-min swimming exercise. The results indicated that CCP-1X supplementation significantly improved grip strength; reduced fatigue-associated biochemical indices, including lactate and ammonia levels; and ameliorated skeletal muscle injury induced by acute exercise challenge. A trend analysis revealed that CCP supplementation significantly increased grip strength and dose-dependently reduced serum alkaline phosphatase, uric acid, triacylglycerol, and glucose levels in healthy mice. Therefore, CCP is a potential agent with an antifatigue pharmacological effect.
authors.affiliation: Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan.
authors.forename: Chi-Chang
authors.initials: CC
authors.lastname: Huang
authors.affiliation: Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Chen
authors.affiliation: Graduate Institute of Athletics and Coaching Science, College of Sports and Athletics, National Taiwan Sport University, Taoyuan 33301, Taiwan.
authors.forename: Nai-Wen
authors.initials: NW
authors.lastname: Kan
authors.affiliation: Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Chao
authors.affiliation: Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan.
authors.forename: Chin-Shan
authors.initials: CS
authors.lastname: Ho
authors.affiliation: Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. meichich@kmu.edu.tw.
authors.forename: Mei-Chich
authors.initials: MC
authors.lastname: Hsu
mesh_terms: D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000097:blood; D000641:Ammonia / Q000097:blood; D000818:Animals; D000999:Antlers / Q000737:chemistry*; D001786:Blood Glucose / Q000378:metabolism; D045424:Complex Mixtures / Q000737:chemistry; D003670:Deer; D005221:Fatigue / Q000097:blood / Q000517:prevention & control*; D019344:Lactic Acid / Q000097:blood; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D053580:Muscle Strength / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D010805:Physical Conditioning, Animal; D005082:Physical Exertion / Q000187:drug effects*; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D018758:Stimulants, Historical / Q000302:isolation & purification / Q000494:pharmacology*; D013550:Swimming / Q000502:physiology
chemical_list: D001786:Blood Glucose; D045424:Complex Mixtures; D020011:Protective Agents; D018758:Stimulants, Historical; D019344:Lactic Acid; D000641:Ammonia; D000469:Alkaline Phosphatase
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