title: Long-Term Remission of an Aggressive Sebaceous Carcinoma following Chemotherapy.
abstract: Sebaceous carcinoma (SC) is an uncommon neoplasm manifesting itself either in the eyelid or extraocularly in the head and neck area. Surgery is the standard of care. Irradiation is rarely proposed as monotherapy but is frequently administered as an adjuvant regimen following surgical resection. There is no known strategy concerning chemotherapeutic treatment in highly aggressive recurrent - or metastatic - forms of the disease. Our patient presented with an aggressive SC of the scalp recurring after multiple excisions and local radiotherapy. Chemotherapy with 5-fluorouracil, cisplatin and docetaxel was then initiated; 4 cycles were administered, followed by capecitabine maintenance. Shortly after starting chemotherapy, dermal lesions had completely disappeared and radiological response could be seen. The patient experienced an extended period (>20 months) of complete remission. In this report, we show an excellent response of a highly aggressive SC after a combination of chemotherapy as for head and neck cancers.
authors.affiliation: Multidisciplinary Oncology Center, University Hospital, Lausanne, Switzerland.
authors.forename: Angela
authors.initials: A
authors.lastname: Orcurto
authors.affiliation: Multidisciplinary Oncology Center, University Hospital, Lausanne, Switzerland.
authors.forename: Béatrice E
authors.initials: BE
authors.lastname: Gay
authors.affiliation: Radiation Oncology Service, University Hospital, Lausanne, Switzerland.
authors.forename: Wendy Jeanneret
authors.initials: WJ
authors.lastname: Sozzi
authors.affiliation: Dermatology Service, University Hospital, Lausanne, Switzerland.
authors.forename: Michel
authors.initials: M
authors.lastname: Gilliet
authors.affiliation: Multidisciplinary Oncology Center, University Hospital, Lausanne, Switzerland.
authors.forename: Serge
authors.initials: S
authors.lastname: Leyvraz
keywords: Chemotherapy; Head and neck area; Managements; Multiple recurrences; Sebaceous carcinoma
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