title: Transplantation of adipose-derived stem cells combined with decellularized cartilage ECM: a novel approach to nasal septum perforation repair.
abstract: Nasal septal perforation, a defect of the nasal mucoperichondrium and cartilage, may induce epistaxis, persistent rhinorrhea and nasal obstruction. Cell-based tissue engineering is a promising therapeutic method for the treatment of nasal septal perforation. However, lack of an adequate source of cells and unsuitable biomaterials greatly hinder the development of cell-based therapy. In this paper, we proposed the application of adipose-derived stem cells combined with decellularized cartilage ECM as a potential graft for the damaged nasal septum, which could help to repair the mucosal and cartilage tissues in the treatment of nasal septal perforation. This new technology could play a novel role in the repair of nasal septal perforation, and in regeneration of damaged nasal cartilage.
authors.affiliation: Department of Otolaryngology, Peking University International Hospital, Peking University, No. 1, Life Science Park Road, Changping District, 102206 Beijing, China; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, China. Electronic address: menghangwang@gmail.com.
authors.forename: Menghang
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology, Peking University People's Hospital, Peking University, No. 11, Xizhimen South Street, Xicheng District, 100044 Beijing, China. Electronic address: yulish68@163.com.
authors.forename: Lisheng
authors.initials: L
authors.lastname: Yu
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D053687:Adult Stem Cells / Q000637:transplantation*; D002356:Cartilage / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism / Q000637:transplantation*; D006801:Humans; D008954:Models, Biological; D061270:Nasal Septal Perforation / Q000601:surgery*