title: Comparative effects of hispidulin, genistein, and icariin with estrogen on bone tissue in ovariectomized rats.
abstract: Icariin, Genistein, and Hispidulin have been proven to have estrogen-like and antiosteoporotic activity and can be potentially used for the treatment of osteoporosis. The present study found that Icariin, Genistein, and Hispidulin treatments, emulating estrogen, significantly contributed to bone density. Comparative effects of Icariin, Genistein, and Hispidulin with estrogen on in ovariectomized rats were investigated. Our results showed that genistein was found to have superior bone protective effects against osteoporosis among genistein, Icariin, and Hispidulin.
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong, China, drlijuanyang@163.com.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Yang
authors.forename: Zixu
authors.initials: Z
authors.lastname: Yu
authors.forename: Haili
authors.initials: H
authors.lastname: Qu
authors.forename: Minmin
authors.initials: M
authors.lastname: Li
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D005260:Female; D047309:Flavones / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D019833:Genistein / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy / Q000517:prevention & control; D010052:Ovariectomy / Q000009:adverse effects; D048789:Phytoestrogens / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016482:Urinalysis; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects
chemical_list: D015415:Biomarkers; D047309:Flavones; D005419:Flavonoids; D048789:Phytoestrogens; D019833:Genistein; C055957:hispidulin; C056599:icariin