title: Hematopoietic stem cell transplantation activity and trends at a pediatric transplantation center in Turkey during 1998-2008.
abstract: OBJECTIVE
  The aim of this study was to document hematopoietic stem cell transplantation (HSCT) activity and trends at our treatment center.
  
  
  METHODS
  Data collected over a 10-year period were retrospectively analyzed, concentrating primarily on types of HSCT, transplant-related mortality (TRM), stem cell sources, indications for HSCT, and causes of death following HSCT.
  
  
  RESULTS
  In total, 222 allogeneic (allo)-HSCT (87.4%) and 32 autologous (auto)-HSCT (12.6%) procedures were performed between 1998 and 2008. Stem cells obtained from unrelated donors were used in 22.6% (50/222) of the allo- HSCTs. Cord blood was the source of hematopoietic stem cells (HSC) in 12.2% of all transplants. The most common indication for allo-HSCT was hemoglobinopathy (43.2%), versus neuroblastoma (53.1%) for auto-HSCT. The TRM rate 1 year post transplantation was 18.3% ± 2.5% for all transplants, but differed according to transplantation type (23.5% ± 7.9% for auto-HSCT and 17.5% ± 2.6% for allo-HSCT). The most common cause of death 1 year post HSCT was infection (35.9%).
  
  
  CONCLUSIONS
  The TRM rate in the patients that underwent allo-HSCT was similar to that which has been previously reported; however, the TRM rate in the patients that underwent auto-HSCT was higher than previously reported in developed countries. The selection of these patients to be transplanted must be made attentively.
authors.affiliation: Akdeniz University, School of Medicine, Department of Pediatric Hematology, Oncology and BMT Unit, Antalya, Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Hazar
authors.affiliation: Akdeniz University, School of Medicine, Department of Pediatric Hematology, Oncology and BMT Unit, Antalya, Turkey.
authors.forename: Gülsün
authors.initials: G
authors.lastname: Karasu
authors.affiliation: Akdeniz University, School of Medicine, Department of Pediatric Hematology, Oncology and BMT Unit, Antalya, Turkey.
authors.forename: Vedat
authors.initials: V
authors.lastname: Uygun
authors.affiliation: Akdeniz University, School of Medicine, Department of Pediatric Hematology, Oncology and BMT Unit, Antalya, Turkey.
authors.forename: Mediha
authors.initials: M
authors.lastname: Akcan
authors.affiliation: Akdeniz University, School of Medicine, Department of Pediatric Hematology, Oncology and BMT Unit, Antalya, Turkey.
authors.forename: Alphan
authors.initials: A
authors.lastname: Küpesiz
authors.affiliation: Akdeniz University, School of Medicine, Department of Pediatric Hematology, Oncology and BMT Unit, Antalya, Turkey.
authors.forename: Akif
authors.initials: A
authors.lastname: Yeşilipek
keywords: Hematopoietic stem cell transplantation; Pediatric; Transplant-related mortality; Turkey
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