title: [The role of microRNAs in molecular pathology of esophageal cancer and their potential usage in clinical oncology].
abstract: MicroRNAs are an abundant class of noncoding RNAs (approx. 18- 25 nucleotides in length) that suppress translation through binding to their target mRNAs, eventually leading to mRNAs degradation. Sequences of these endogenous RNA molecules are highly conserved, even among unrelated species, indicating their involvement in basic bio-logical processes, such as development, differentiation, proliferation or apoptosis. MiRNAs also participate on regulation of cancer stem cell functioning, immune system and malignant transformation. This review provides a comprehensive overview of miRNAs functions in esophageal cancer, their roles in key pathogenetic pathways and disease development, as well as their potential usage in clinical routine as bio-markers improving dia-gnosis, prognosis and prediction of therapeutic response. Through regulation of signaling pathways important in malignant transformation, miRNAs present also promising therapeutic targets.
authors.forename: A
authors.initials: A
authors.lastname: Kovaříková
authors.forename: R
authors.initials: R
authors.lastname: Héžová
authors.forename: J
authors.initials: J
authors.lastname: Srovnal
authors.forename: M
authors.initials: M
authors.lastname: Rédová-Lojová
authors.forename: O
authors.initials: O
authors.lastname: Slabý
mesh_terms: D001471:Barrett Esophagus / Q000235:genetics*; D015415:Biomarkers / Q000032:analysis; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000032:analysis / Q000502:physiology*; D011379:Prognosis; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D035683:MicroRNAs