title: Muju virus, harbored by Myodes regulus in Korea, might represent a genetic variant of Puumala virus, the prototype arvicolid rodent-borne hantavirus.
abstract: The genome of Muju virus (MUJV), identified originally in the royal vole (Myodes regulus) in Korea, was fully sequenced to ascertain its genetic and phylogenetic relationship with Puumala virus (PUUV), harbored by the bank vole (My. glareolus), and a PUUV-like virus, named Hokkaido virus (HOKV), in the grey red-backed vole (My. rufocanus) in Japan. Whole genome sequence analysis of the 6544-nucleotide large (L), 3652-nucleotide medium (M) and 1831-nucleotide small (S) segments of MUJV, as well as the amino acid sequences of their gene products, indicated that MUJV strains from different capture sites might represent genetic variants of PUUV, the prototype arvicolid rodent-borne hantavirus in Europe. Distinct geographic-specific clustering of MUJV was found in different provinces in Korea, and phylogenetic analyses revealed that MUJV and HOKV share a common ancestry with PUUV. A better understanding of the taxonomic classification and pathogenic potential of MUJV must await its isolation in cell culture.
authors.affiliation: Department of Microbiology, College of Medicine, and the Institute for Viral Diseases, Korea University, Seoul 136-705, Korea. jingoo84@gmail.com.
authors.forename: Jin Goo
authors.initials: JG
authors.lastname: Lee
authors.affiliation: Department of Microbiology, College of Medicine, and the Institute for Viral Diseases, Korea University, Seoul 136-705, Korea. gsehun@korea.ac.kr.
authors.forename: Se Hun
authors.initials: SH
authors.lastname: Gu
authors.affiliation: Department of Microbiology, College of Medicine, and the Institute for Viral Diseases, Korea University, Seoul 136-705, Korea. baekmicr@korea.ac.kr.
authors.forename: Luck Ju
authors.initials: LJ
authors.lastname: Baek
authors.affiliation: Department of Biomedical Science, College of Medicine, Korea University, Seoul 136-705, Korea. sarahshin79@gmail.com.
authors.forename: Ok Sarah
authors.initials: OS
authors.lastname: Shin
authors.affiliation: Department of Microbiology, College of Medicine, and the Institute for Viral Diseases, Korea University, Seoul 136-705, Korea. parkbcmb@korea.ac.kr.
authors.forename: Kwang Sook
authors.initials: KS
authors.lastname: Park
authors.affiliation: Medical Detachment, 168th Multifunctional Medical Battalion, 65th Medical Brigade, Unit 15247, APO AP 96205-5247, USA. hungchol.kim@us.army.mil.
authors.forename: Heung-Chul
authors.initials: HC
authors.lastname: Kim
authors.affiliation: Public Health Command Region-Pacific, 65th Medical Brigade, Unit 15281, APO AP 96205-5281, USA. terry.a.klein2.civ@mail.mil.
authors.forename: Terry A
authors.initials: TA
authors.lastname: Klein
authors.affiliation: Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA. ryanagih@hawaii.edu.
authors.forename: Richard
authors.initials: R
authors.lastname: Yanagihara
authors.affiliation: Department of Microbiology, College of Medicine, and the Institute for Viral Diseases, Korea University, Seoul 136-705, Korea. jwsong@korea.ac.kr.
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Song
mesh_terms: D000818:Animals; D003411:Arvicolinae / Q000821:virology*; D016000:Cluster Analysis; D014644:Genetic Variation; D016679:Genome, Viral; D007723:Korea; D008969:Molecular Sequence Data; D058974:Phylogeography; D029262:Puumala virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012367:RNA, Viral / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D012367:RNA, Viral
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