title: A prospective study of surgical procedures for patients with oligometastatic non-small cell lung cancer.
abstract: BACKGROUND
  Purely localized, oligometastatic, and widely metastatic tumors are likely to require different therapeutic strategies. Although surgical procedures for isolated pulmonary, brain, or adrenal metastases from lung cancer have been extensively evaluated, most data are from retrospective studies; accordingly, we conducted a prospective multicenter trial.
  
  
  METHODS
  Patients were eligible if they had previously untreated clinical T1-2N0-1 lung cancer with single-organ metastasis, or single-organ metachronous metastasis after complete resection of pathologic T1-2N0-1 lung cancer. Metastatic lesions were classified into three groups: group A included metastasis in single organs other than brain or lung; group B included synchronous brain metastasis; and group C included pulmonary metastasis. The treatment intervention was surgical resection of metachronous metastasis or of both synchronous metastasis and primary lung cancer.
  
  
  RESULTS
  From December 2002 through June 2011, 36 patients were enrolled. Two patients were ineligible, and the remaining 34 were analyzed; 6 (18%) had a benign lesion and no metastasis, 5 patients (15%) underwent incomplete resection of primary lung cancer, and 20 patients (59%) underwent complete resection of both primary lung cancer and metastasis. The 5-year survival rate for these 20 cases was 44.7%.
  
  
  CONCLUSIONS
  Clinical T1-2N0-1 lung cancer with a single-organ metastatic lesion was a good candidate for surgical resection. A 5-year survival rate of about 40% can be expected, which could be comparable with that for stage II non-small cell lung cancer.
authors.affiliation: Japanese Northern East Area Thoracic Surgery Study Group (JNETS); Department of Thoracic Surgery, Tohoku University Hospital, Sendai, Japan. Electronic address: endo@idac.tohoku.ac.jp.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Endo
authors.affiliation: Japanese Northern East Area Thoracic Surgery Study Group (JNETS); Department of Thoracic Surgery, Sendai Medical Center, Sendai, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Hasumi
authors.affiliation: Japanese Northern East Area Thoracic Surgery Study Group (JNETS); Department of Thoracic Surgery, Ohta Nishinouchi Hospital, Kohriyama, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsumura
authors.affiliation: Japanese Northern East Area Thoracic Surgery Study Group (JNETS); Department of Thoracic Surgery, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Sato
authors.affiliation: Japanese Northern East Area Thoracic Surgery Study Group (JNETS); Department of Thoracic Surgery, Iwate Medical University Hospital, Morioka, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Deguchi
authors.affiliation: Japanese Northern East Area Thoracic Surgery Study Group (JNETS); Second Department of Surgery, Yamagata University Hospital, Yamagata, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Oizumi
authors.affiliation: Japanese Northern East Area Thoracic Surgery Study Group (JNETS); Department of Thoracic Surgery, Kanazawa Medical University Hospital, Kahoku, Japan.
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Sagawa
authors.affiliation: Japanese Northern East Area Thoracic Surgery Study Group (JNETS); Department of Thoracic and Cardiovascular Surgery, Hirosaki University Hospital, Hirosaki, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Tsushima
authors.affiliation: Japanese Northern East Area Thoracic Surgery Study Group (JNETS); Department of Thoracic Surgery, Miyagi Cancer Center, Natori, Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Japanese Northern East Area Thoracic Surgery Study Group (JNETS); Department of Thoracic Surgery, Iwate Prefectural Isawa Hospital, Ohshuu, Japan.
authors.forename: Jotaro
authors.initials: J
authors.lastname: Shibuya
authors.affiliation: Japanese Northern East Area Thoracic Surgery Study Group (JNETS); Department of Thoracic Surgery, Shizuoka General Hospital, Shizuoka, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Hirose
authors.affiliation: Japanese Northern East Area Thoracic Surgery Study Group (JNETS); Department of Thoracic Surgery, Tohoku University Hospital, Sendai, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D059146:Metastasectomy / Q000379:methods*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000379:methods*; D011446:Prospective Studies; D015996:Survival Rate / Q000639:trends