title: Vitamin D levels and menopause-related symptoms.
abstract: OBJECTIVE
  This study aims to determine whether vitamin D levels are associated with menopause-related symptoms in older women.
  
  
  METHODS
  A randomly selected subset of 1,407 women, among 26,104 potentially eligible participants of the Women's Health Initiative Calcium and Vitamin D trial of postmenopausal women aged 51 to 80 years, had 25-hydroxyvitamin D [25(OH)D] levels measured at the Women's Health Initiative Calcium and Vitamin D trial baseline visit. Information about menopause-related symptoms at baseline was obtained by questionnaire and included overall number of symptoms and composite measures of sleep disturbance, emotional well-being, and energy/fatigue, as well as individual symptoms. After exclusions for missing data, 530 women (mean [SD] age, 66.2 [6.8] y) were included in these analyses.
  
  
  RESULTS
  Borderline significant associations between 25(OH)D levels and total number of menopausal symptoms were observed (with P values ranging from 0.05 to 0.06 for fully adjusted models); however, the effect was clinically insignificant and disappeared with correction for multiple testing. No associations between 25(OH)D levels and composite measures of sleep disturbance, emotional well-being, or energy/fatigue were observed (P's > 0.10 for fully adjusted models).
  
  
  CONCLUSIONS
  There is no evidence for a clinically important association between serum 25(OH)D levels and menopause-related symptoms in postmenopausal women.
authors.affiliation: From the 1Center for Health Research, Kaiser Permanente Northwest, Portland, OR; 2Quantitative Sciences Unit, Department of Medicine, Stanford University School of Medicine, Stanford, CA; 3University of Buffalo, Buffalo, NY; 4Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 5Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA; 6Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA; 7Department of Medicine, Stanford University School of Medicine, Stanford, CA; 8University of Tennessee Health Science Center, Memphis, TN; 9Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA; 10Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN; 11University of Miami, Miami, FL; 12Biobehavioral Nursing, University of Washington, Seattle, WA; and 13Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA.
authors.forename: Erin S
authors.initials: ES
authors.lastname: LeBlanc
authors.forename: Manisha
authors.initials: M
authors.lastname: Desai
authors.forename: Nancy
authors.initials: N
authors.lastname: Perrin
authors.forename: Jean
authors.initials: J
authors.lastname: Wactawski-Wende
authors.forename: JoAnn E
authors.initials: JE
authors.lastname: Manson
authors.forename: Jane A
authors.initials: JA
authors.lastname: Cauley
authors.forename: Yvonne L
authors.initials: YL
authors.lastname: Michael
authors.forename: Jean
authors.initials: J
authors.lastname: Tang
authors.forename: Catherine
authors.initials: C
authors.lastname: Womack
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Song
authors.forename: Karen C
authors.initials: KC
authors.lastname: Johnson
authors.forename: Mary J
authors.initials: MJ
authors.lastname: O'Sullivan
authors.forename: Nancy
authors.initials: N
authors.lastname: Woods
authors.forename: Marcia L
authors.initials: ML
authors.lastname: Stefanick
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000378:metabolism; D002136:Calcium, Dietary / Q000008:administration & dosage; D003430:Cross-Sectional Studies; D019587:Dietary Supplements; D004644:Emotions; D015444:Exercise; D005221:Fatigue / Q000097:blood; D005260:Female; D006801:Humans; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D012893:Sleep Wake Disorders / Q000097:blood; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D016387:Women's Health
chemical_list: D002136:Calcium, Dietary; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D002118:Calcium
references.citation: Menopause. 2009 Nov-Dec;16(6):1213-7
references.pmid: 19455070
references.citation: J Womens Health (Larchmt). 2006 Mar;15(2):135-45
references.pmid: 16536677
references.citation: Gynecol Endocrinol. 2006 Aug;22(8):441-6
references.pmid: 17012106
references.citation: Arch Gen Psychiatry. 2004 Jan;61(1):62-70
references.pmid: 14706945
references.citation: Public Health Nutr. 1999 Sep;2(3):273-6
references.pmid: 10512561
references.citation: J Bone Miner Res. 1989 Aug;4(4):469-75
references.pmid: 2816496
references.citation: Ann Epidemiol. 2003 Oct;13(9 Suppl):S78-86
references.pmid: 14575940
references.citation: Med Care. 1992 Jun;30(6):473-83
references.pmid: 1593914
references.citation: Menopause. 2012 Mar;19(3):250-2
references.pmid: 22228323
references.citation: Evid Rep Technol Assess (Summ). 2005 Mar;(120):1-6
references.pmid: 15910013
references.citation: Obstet Gynecol. 2007 Aug;110(2 Pt 1):230-40
references.pmid: 17666595
references.citation: Maturitas. 2002 Jul 25;42(3):195-200
references.pmid: 12161043
references.citation: Obstet Gynecol. 2005 May;105(5 Pt 1):1063-73
references.pmid: 15863546
references.citation: N Engl J Med. 2006 Feb 16;354(7):684-96
references.pmid: 16481636
references.citation: Calcif Tissue Int. 1986 Sep;39(3):139-44
references.pmid: 3093024
references.citation: Psychol Assess. 2003 Jun;15(2):137-48
references.pmid: 12847774
references.citation: Obstet Gynecol. 1998 Dec;92(6):982-8
references.pmid: 9840563
references.citation: JAMA. 2011 Jan 19;305(3):267-74
references.pmid: 21245182
references.citation: J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30
references.pmid: 21646368
references.citation: Hum Reprod. 2002 May;17(5):1379-85
references.pmid: 11980768
references.citation: Ann Epidemiol. 2003 Oct;13(9 Suppl):S98-106
references.pmid: 14575942
references.citation: Am J Psychiatry. 2004 Dec;161(12):2238-44
references.pmid: 15569895
references.citation: JAMA. 2002 Jul 17;288(3):321-33
references.pmid: 12117397
references.citation: Ind Health. 2011;49(5):566-74
references.pmid: 21804271
references.citation: Obstet Gynecol. 2000 Sep;96(3):351-8
references.pmid: 10960625
references.citation: Menopause. 2009 May-Jun;16(3):453-7
references.pmid: 19188852
references.citation: J Natl Cancer Inst. 1995 Sep 20;87(18):1372-82
references.pmid: 7658498
references.citation: Eur J Clin Nutr. 1999 Dec;53(12):920-6
references.pmid: 10602348
references.citation: Menopause. 2009 Jan-Feb;16(1):73-6
references.pmid: 18779760
references.citation: JAMA. 2004 Apr 14;291(14):1701-12
references.pmid: 15082697
references.citation: Am J Clin Nutr. 2000 Sep;72(3):690-3
references.pmid: 10966885
references.citation: Qual Life Res. 1994 Feb;3(1):7-12
references.pmid: 8142947
references.citation: Endocr Pract. 2009 Apr;15(3):203-12
references.pmid: 19364687
references.citation: Maturitas. 1996 Apr;23(3):293-9
references.pmid: 8794423
references.citation: N Engl J Med. 2006 Feb 16;354(7):669-83
references.pmid: 16481635
references.citation: Psychopharmacology (Berl). 1998 Feb;135(4):319-23
references.pmid: 9539254
references.citation: Ann N Y Acad Sci. 2006 Aug;1074:261-71
references.pmid: 17105922
references.citation: Am J Clin Nutr. 2010 May;91(5):1324-35
references.pmid: 20219959
references.citation: Gynecol Endocrinol. 2009 May;25(5):303-14
references.pmid: 19903037
references.citation: JAMA. 2005 Jul 13;294(2):183-93
references.pmid: 16014592
references.citation: Breast Cancer Res Treat. 2010 Jan;119(1):111-8
references.pmid: 19655244
references.citation: JAMA. 2006 May 3;295(17):2057-71
references.pmid: 16670414
references.citation: J Natl Cancer Inst. 2008 Nov 19;100(22):1581-91
references.pmid: 19001601
references.citation: Maturitas. 2000 Oct 31;36(3):155-64
references.pmid: 11063896
references.citation: Ann Intern Med. 2005 Jun 21;142(12 Pt 1):1003-13
references.pmid: 15968015
references.citation: Menopause. 2012 Mar;19(3):278-82
references.pmid: 21997498
references.citation: J Nutr Health Aging. 1999;3(1):5-7
references.pmid: 10888476
references.citation: Menopause. 2010 Sep-Oct;17(5):946-54
references.pmid: 20505547
references.citation: J Gen Intern Med. 2008 Sep;23(9):1507-13
references.pmid: 18521690
references.citation: J Intern Med. 2008 Dec;264(6):599-609
references.pmid: 18793245
references.citation: Ann Epidemiol. 2003 Oct;13(9 Suppl):S87-97
references.pmid: 14575941
references.citation: Am J Public Health. 2001 Sep;91(9):1435-42
references.pmid: 11527777
references.citation: Maturitas. 1992 Jan;14(2):103-15
references.pmid: 1565019