title: Reduction in labor pain by intrathecal midazolam as an adjunct to sufentanil.
abstract: BACKGROUND
  Anesthesia today has strived to decrease labor pain in a tolerable and controllable fashion. Intrathecal midazolam has been introduced as an adjunct to analgesics. The study was planned to assess the efficacy, safety and duration of analgesia produced by intrathecal midazolam adjunct to sufentanil in decreasing labor pain.
  
  
  METHODS
  In a randomized clinical trial 80 parturient included in the study. The two groups were matched for age, cervical dilation, gravid, gestational age, and other demographic characteristics. Combination of sufentanil and midazolam administered intrathecally to experimental group and compared to sufentanil group. Time to reach maximum block, and pain score was measured and recorded.
  
  
  RESULTS
  Groups were matched for age and weight and other demographic characteristic. No significant adverse effect was seen in both groups including decrease in Apgar score. Duration of analgesia was 92.0 ± 12.7 in sufentanil group and 185.2 ± 15.2 minutes in midazolam and sufentanil group which was significantly different (P = 0.002). Numeric rating scale score was significantly lower in midazolam group compare to sufentanil group at 120 min (P = 0.01), 150 min (P = 0.0014), and 180 min (P = 0.001).
  
  
  CONCLUSIONS
  Intrathecal midazolam as an adjunct to opioid could significantly enhance analgesia in labor pain with no significant adverse effect. Intrathecal injection of midazolam is an appropriate alternative to parenteral or epidural analgesia in small hospital settings.
authors.affiliation: Department of Anesthesiology, Loghman Hospital, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Salimi
authors.affiliation: Department of Anesthesiology, Loghman Hospital, Tehran, Iran.
authors.forename: Reza Amin
authors.initials: RA
authors.lastname: Nejad
authors.affiliation: Department of Anesthesiology, Loghman Hospital, Tehran, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Safari
authors.affiliation: Department of Anesthesiology, Loghman Hospital, Tehran, Iran.
authors.forename: Seyed Amir
authors.initials: SA
authors.lastname: Mohajaerani
authors.affiliation: Department of Anesthesiology, Sarem Obstetric Hospital, Tehran, Iran.
authors.forename: Rahim Jahanbakhsh
authors.initials: RJ
authors.lastname: Naghade
authors.affiliation: Department of Anesthesiology, Loghman Hospital, Tehran, Iran.
authors.forename: Kamran
authors.initials: K
authors.lastname: Mottaghi
keywords: Analgesia; Intrathecal midazolam; Labor pain
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