title: Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer.
abstract: A nanotheranostic agent has been readily fabricated by encapsulating tantalum oxide (TaOx) nanoparticles (NPs) into polypyrrole (PPy) NPs via a facile one-step chemical oxidation polymerization for bimodal imaging guided photothermal ablation of tumor. It was proved that the obtained composite nanoparticles (TaOx@PPy NPs) with an average diameter around 45 nm could operate as an efficient bimodal contrast agent to simultaneously enhance X-ray CT and photoacoustic (PA) imaging greatly in vivo. Systemically administered TaOx@PPy NPs could passively accumulate at the tumor site during the blood circulation, which was proved by both CT and PA imaging. In addition, the in vivo therapeutic examinations showed that TaOx@PPy NPs exhibited significant photothermal cytotoxicity under near infrared laser irradiation. The tumor growth inhibition was evaluated to be 66.5% for intravenously injection and 100% for intratumoral injection, respectively. This versatile agent can be developed as a smart and promising nanoplatform that integrates multiple capabilities for both accurate diagnosing and precise locating of cancerous tissue, as well as effective photoablation of tumor.
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Yushen
authors.initials: Y
authors.lastname: Jin
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Xibo
authors.initials: X
authors.lastname: Ma
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Zhengbao
authors.initials: Z
authors.lastname: Zha
authors.affiliation: Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Shi
authors.affiliation: Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China. Electronic address: zhifei.dai@pku.edu.cn.
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Dai
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D007259:Infrared Rays; D015552:Injections, Intralesional; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D010087:Oxides / Q000008:administration & dosage / Q000627:therapeutic use*; D061088:Photoacoustic Techniques; D010789:Phototherapy; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013635:Tantalum / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D010087:Oxides; D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole; D013635:Tantalum; C078151:tantalum oxide
keywords: CT imaging; Photoacoustic imaging; Photothermal therapy; Polypyrrole; Tantalum oxide nanoparticle