title: Glycation: the angiogenic paradox in aging and age-related disorders and diseases.
abstract: Angiogenesis is generally a quiescent process which, however, may be modified by different physiological and pathological conditions. The "angiogenic paradox" has been described in diabetes because this disease impairs the angiogenic response in a manner that differs depending on the organs involved and disease evolution. Aging is also associated with pro- and antiangiogenic processes. Glycation, the post-translational modification of proteins, increases with aging and the progression of diabetes. The effect of glycation on angiogenesis depends on the type of glycated proteins and cells involved. This complex link could be responsible for the "angiogenic paradox" in aging and age-related disorders and diseases. Using diabetes as a model, the present work has attempted to review the age-related angiogenic paradox, in particular the effects of glycation on angiogenesis during aging.
authors.affiliation: Vascular Aging Biology, Blood-Vessel Interface and Vascular Repair Unit, Lille School of Medicine, Lille2 University, Lille, France; Geriatrics Department, Rouen University Hospital, Rouen, France. Electronic address: rocafr@gmail.com.
authors.forename: F
authors.initials: F
authors.lastname: Roca
authors.affiliation: Vascular Aging Biology, Blood-Vessel Interface and Vascular Repair Unit, Lille School of Medicine, Lille2 University, Lille, France.
authors.forename: N
authors.initials: N
authors.lastname: Grossin
authors.affiliation: Geriatrics Department, Rouen University Hospital, Rouen, France.
authors.forename: P
authors.initials: P
authors.lastname: Chassagne
authors.affiliation: Vascular Aging Biology, Blood-Vessel Interface and Vascular Repair Unit, Lille School of Medicine, Lille2 University, Lille, France; Gerontology Clinic, Les Bateliers Geriatric Hospital, Lille University Hospital, Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Puisieux
authors.affiliation: Vascular Aging Biology, Blood-Vessel Interface and Vascular Repair Unit, Lille School of Medicine, Lille2 University, Lille, France; Gerontology Clinic, Les Bateliers Geriatric Hospital, Lille University Hospital, Lille, France.
authors.forename: E
authors.initials: E
authors.lastname: Boulanger
mesh_terms: D000375:Aging / Q000473:pathology*; D017127:Glycation End Products, Advanced / Q000235:genetics / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011499:Protein Processing, Post-Translational / Q000235:genetics*
chemical_list: D017127:Glycation End Products, Advanced
keywords: Aging; Angiogenesis; Angiogenic paradox; Diabetes; Glycation