title: Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities.
abstract: BACKGROUND
  Defining the RNA transcriptome in Alzheimer Disease (AD) will help understand the disease mechanisms and provide biomarkers. Though the AD blood transcriptome has been studied, effects of white matter hyperintensities (WMH) were not considered. This study investigated the AD blood transcriptome and accounted for WMH.
  
  
  METHODS
  RNA from whole blood was processed on whole-genome microarrays.
  
  
  RESULTS
  A total of 293 probe sets were differentially expressed in AD versus controls, 5 of which were significant for WMH status. The 288 AD-specific probe sets classified subjects with 87.5% sensitivity and 90.5% specificity. They represented 188 genes of which 29 have been reported in prior AD blood and 89 in AD brain studies. Regulated blood genes included MMP9, MME (Neprilysin), TGFβ1, CA4, OCLN, ATM, TGM3, IGFR2, NOV, RNF213, BMX, LRRN1, CAMK2G, INSR, CTSD, SORCS1, SORL1, and TANC2.
  
  
  CONCLUSIONS
  RNA expression is altered in AD blood irrespective of WMH status. Some genes are shared with AD brain.
authors.affiliation: *CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences †CAS Key Laboratory of Genome Sciences and Information, University of Chinese Academy of Sciences, Beijing, China ‡Department of Neurology and MIND Institute, School of Medicine ∥Alzheimer's Disease Center, School of Medicine, University of California at Davis, Sacramento, CA §Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.
authors.forename: Zhouxian
authors.initials: Z
authors.lastname: Bai
authors.forename: Boryana
authors.initials: B
authors.lastname: Stamova
authors.forename: Huichun
authors.initials: H
authors.lastname: Xu
authors.forename: Bradley P
authors.initials: BP
authors.lastname: Ander
authors.forename: Jiajia
authors.initials: J
authors.lastname: Wang
authors.forename: Glen C
authors.initials: GC
authors.lastname: Jickling
authors.forename: Xinhua
authors.initials: X
authors.lastname: Zhan
authors.forename: DaZhi
authors.initials: D
authors.lastname: Liu
authors.forename: Guangchun
authors.initials: G
authors.lastname: Han
authors.forename: Lee-Way
authors.initials: LW
authors.lastname: Jin
authors.forename: Charles
authors.initials: C
authors.lastname: DeCarli
authors.forename: Hongxing
authors.initials: H
authors.lastname: Lei
authors.forename: Frank R
authors.initials: FR
authors.lastname: Sharp
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics* / Q000473:pathology; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D012313:RNA / Q000097:blood*; D059467:Transcriptome; D066127:White Matter / Q000473:pathology*
chemical_list: D015415:Biomarkers; D012313:RNA
references.citation: Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):955-60
references.pmid: 17215369
references.citation: J Alzheimers Dis. 2011;25(1):59-76
references.pmid: 21368376
references.citation: Alzheimers Dement. 2010 Jan;6(1):25-38
references.pmid: 20129318
references.citation: J Cereb Blood Flow Metab. 2010 Nov;30(11):1817-20
references.pmid: 20717123
references.citation: IUBMB Life. 2012 Dec;64(12):951-7
references.pmid: 23129399
references.citation: J Neurosci Res. 2009 May 1;87(6):1462-73
references.pmid: 19021293
references.citation: J Alzheimers Dis. 2012;30(3):685-710
references.pmid: 22466004
references.citation: J Neurosci. 2013 Feb 6;33(6):2457-64
references.pmid: 23392674
references.citation: Brain Pathol. 2009 Oct;19(4):612-22
references.pmid: 18673368
references.citation: J Alzheimers Dis. 2013;35(2):373-86
references.pmid: 23411692
references.citation: Prog Neurobiol. 2001 Aug;64(6):575-611
references.pmid: 11311463
references.citation: J Gerontol A Biol Sci Med Sci. 2009 Jun;64(6):636-45
references.pmid: 19366883
references.citation: Mol Neurodegener. 2011 Jul 05;6:47
references.pmid: 21729327
references.citation: Immunol Lett. 2007 Nov 30;114(1):46-51
references.pmid: 17949824
references.citation: Neuromolecular Med. 2010 Dec;12(4):331-40
references.pmid: 20571935
references.citation: J Alzheimers Dis. 2012;28(2):433-41
references.pmid: 22008264
references.citation: Nat Med. 2001 May;7(5):612-8
references.pmid: 11329064
references.citation: Neurobiol Aging. 2010 Feb;31(2):224-43
references.pmid: 18479783
references.citation: PLoS One. 2012;7(7):e40498
references.pmid: 22815752
references.citation: Neurobiol Aging. 2009 Jan;30(1):54-70
references.pmid: 17561313
references.citation: J Alzheimers Dis. 2010;21(3):939-45
references.pmid: 20634585
references.citation: Biochim Biophys Acta. 2010 Aug;1801(8):878-86
references.pmid: 20452460
references.citation: Neurol Sci. 2006 Apr;27(1):33-9
references.pmid: 16688597
references.citation: Eur Neuropsychopharmacol. 2012 Apr;22(4):281-9
references.pmid: 21924590
references.citation: J Alzheimers Dis. 2011;23(1):121-9
references.pmid: 20930265
references.citation: J Alzheimers Dis. 2012;28(2):389-402
references.pmid: 22008267
references.citation: J Alzheimers Dis. 2011;23(1):109-19
references.pmid: 20930264
references.citation: PLoS One. 2011 Jan 31;6(1):e16575
references.pmid: 21304989
references.citation: Neurosci Lett. 2008 Jan 3;430(1):81-6
references.pmid: 18063474
references.citation: J Neurosci. 2012 Jun 27;32(26):8845-54
references.pmid: 22745485
references.citation: J Alzheimers Dis. 2007 May;11(2):153-64
references.pmid: 17522440
references.citation: Top Magn Reson Imaging. 2005 Dec;16(6):399-407
references.pmid: 17088690
references.citation: J Neurosci. 2009 Feb 18;29(7):1977-86
references.pmid: 19228952
references.citation: Stroke. 2010 Dec;41(12):2744-9
references.pmid: 20966416
references.citation: Neurosci Lett. 2011 Nov 7;505(1):25-30
references.pmid: 21970975
references.citation: J Alzheimers Dis. 2011;27(3):665-76
references.pmid: 21860087
references.citation: J Alzheimers Dis. 2011;26(4):779-86
references.pmid: 21694463
references.citation: Neurobiol Aging. 2010 Oct;31(10):1743-57
references.pmid: 19019493
references.citation: Brain Pathol. 2011 Sep;21(5):594-605
references.pmid: 21382117
references.citation: Ann N Y Acad Sci. 2002 Nov;977:87-95
references.pmid: 12480736
references.citation: Int J Alzheimers Dis. 2012;2012:649456
references.pmid: 22482075
references.citation: Arch Neurol. 2008 Dec;65(12):1640-8
references.pmid: 19064752
references.citation: Neuroscience. 2008 Jul 31;155(1):258-62
references.pmid: 18571334