title: Tumor Directed, Scalp Sparing Intensity Modulated Whole Brain Radiotherapy for Brain Metastases.
abstract: Despite significant technical advances in radiation delivery, conventional whole brain radiation therapy (WBRT) has not materially changed in the past 50 years. We hypothesized that IMRT can selectively spare uninvolved brain and scalp with the goal of reducing acute and late toxicity. MRI/CT simulation image registration was performed. We performed IMRT planning to simultaneously treat the brain tumor(s) on MRI + 5 mm margin to 37.5 Gy in 15 fractions while limiting the uninvolved brain + 2 mm margin to 30 Gy in 15 fractions and the mean scalp dose to #18 Gy. Three field IMRT plans were compared to conventional WBRT plans. Symptomatic patients were started on conventional WBRT for 2 to 3 fractions while IMRT planning was performed. Seventeen consecutive patients with brain metastases with RPA class I and II disease with no leptomeningeal spread were treated with IMRT WBRT. Compared to conventional WBRT, IMRT reduced the mean scalp dose (26.2 Gy vs. 16.4 Gy, p < 0.001) and the mean PTV30 dose (38.4 Gy vs. 32.0 Gy, p < 0.001) while achieving similar mean PTV37.5 doses (38.3 Gy vs. 38.0 Gy, p = 0.26). Using Olsen hair loss score criteria, 4 of 15 assessable patients preserved at least 50% of hair coverage at 1 to 3 months after treatment while 6 patients preserved between 25 and 50% hair coverage. At a median follow-up of 6.8 months (range: 5 to 15 months), the median overall survival was 5.4 months. Four patients relapsed within the brain, one within the PTV37.5 and three outside the PTV37.5. Tumor directed, scalp sparing IMRT is feasible, achieves rational dose distributions and preserves partial hair coverage in the majority of patients. Further studies are warranted to determine whether the increased utilization of resources needed for IMRT are appropriate in this setting.
authors.affiliation: Good Samaritan Hospital Medical Center, Department of Radiation Oncology, West Islip, NY, USA Johnny.kao@chsli.org.
authors.forename: Johnny
authors.initials: J
authors.lastname: Kao
authors.affiliation: Good Samaritan Hospital Medical Center, Department of Neurosurgery, West Islip, NY, USA.
authors.forename: Boramir
authors.initials: B
authors.lastname: Darakchiev
authors.affiliation: Good Samaritan Hospital Medical Center, Department of Radiation Oncology, West Islip, NY, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Conboy
authors.affiliation: Good Samaritan Hospital Medical Center, Department of Radiation Oncology, West Islip, NY, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Ogurek
authors.affiliation: Good Samaritan Hospital Medical Center, Department of Radiation Oncology, West Islip, NY, USA.
authors.forename: Neha
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Good Samaritan Hospital Medical Center, Department of Radiation Oncology, West Islip, NY, USA.
authors.forename: Xuemin
authors.initials: X
authors.lastname: Ren
authors.affiliation: Good Samaritan Hospital Medical Center, Department of Radiation Oncology, West Islip, NY, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Pettit
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059351:Organ Sparing Treatments / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D014057:Tomography, X-Ray Computed
keywords: Brain metastases; Intensity modulated radiation therapy; Prophylactic cranial irradiation; Scalp sparing IMRT; Whole brain radiotherapy.