title: Herbal medicine in the treatment of Alzheimer's disease.
abstract: Associated with the aging of our world population is a sharp increase in the incidence of Alzheimer's disease, which not only poses a significant health issue but also presents a serious social problem. Although pharmacological treatments were developed based on existing hypotheses, the disease pathogenesis remains to be fully elucidated. Given the complexity of Alzheimer's disease, Chinese herbal medicine appears to have therapeutic potential for Alzheimer's disease through multi-target and multi-pathway approach at cellular and molecular levels and holistic adjustment of the body at organ system levels. Recently, a significant breakthrough has been made in the research of Chinese medicine for Alzheimer's disease. In this article, we review the experimental research progress in understanding how Chinese medicine could be used for the treatment of Alzheimer's disease.
authors.affiliation: Tianjin University of Traditional Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, 300193, China.
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: Wu
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Wang
authors.forename: Zi-lv
authors.initials: ZL
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D064209:Phytochemicals / Q000627:therapeutic use
chemical_list: D004365:Drugs, Chinese Herbal; D064209:Phytochemicals
references.citation: Curr Alzheimer Res. 2011 Aug;8(5):563-72
references.pmid: 21244356
references.citation: Phytother Res. 2012 Oct;26(10):1528-33
references.pmid: 22322985
references.citation: J Altern Complement Med. 2012 Jul;18(7):647-52
references.pmid: 22747190
references.citation: FASEB J. 2006 Jun;20(8):1269-71
references.pmid: 16636099
references.citation: Neurochem Res. 2012 Apr;37(4):771-7
references.pmid: 22179853
references.citation: J Alzheimers Dis. 2013;33(3):863-80
references.pmid: 23064259
references.citation: J Clin Neurosci. 2004 Jun;11(5):456-67
references.pmid: 15177383
references.citation: Zhejiang Da Xue Xue Bao Yi Xue Ban. 2012 Jul;41(4):393-401
references.pmid: 22927074
references.citation: Cell. 2012 Mar 16;148(6):1204-22
references.pmid: 22424230
references.citation: Neurobiol Aging. 1998 May-Jun;19(3):173-89
references.pmid: 9661992
references.citation: Acta Pharmacol Sin. 2013 Feb;34(2):214-20
references.pmid: 23202798
references.citation: Cell Mol Neurobiol. 2012 Apr;32(3):353-60
references.pmid: 22042506
references.citation: Biochim Biophys Acta. 2012 Feb;1822(2):286-92
references.pmid: 22015470
references.citation: Acta Pharmacol Sin. 2005 Jun;26(6):673-8
references.pmid: 15916732
references.citation: Neurosci Lett. 2004 Apr 22;360(1-2):21-4
references.pmid: 15082169
references.citation: Am J Public Health. 1998 Sep;88(9):1337-42
references.pmid: 9736873
references.citation: Pharmacology. 1991;42(4):223-9
references.pmid: 1852782
references.citation: J Alzheimers Dis. 2006 Sep;10(1):1-7
references.pmid: 16988474
references.citation: Neurosci Lett. 2009 Apr 3;453(2):98-103
references.pmid: 19356601
references.citation: J Ethnopharmacol. 2005 Feb 28;97(2):313-8
references.pmid: 15707771
references.citation: Neuropsychopharmacology. 2004 May;29(5):860-8
references.pmid: 15010693
references.citation: J Neurosci Res. 2010 Mar;88(4):807-15
references.pmid: 19795377
references.citation: Proc Natl Acad Sci U S A. 1976 Jul;73(7):2424-8
references.pmid: 1065897
references.citation: J Ethnopharmacol. 2007 May 22;111(3):458-63
references.pmid: 17257792
references.citation: Neurosci Lett. 2004 Aug 26;367(1):123-8
references.pmid: 15308312
references.citation: Biol Pharm Bull. 1995 Jan;18(1):162-6
references.pmid: 7735233
references.citation: Acta Pharmacol Sin. 2006 Jan;27(1):1-26
references.pmid: 16364207
references.citation: J Alzheimers Dis. 2012;31(1):131-42
references.pmid: 22531425
references.citation: Neuropsychopharmacology. 2011 Apr;36(5):1073-89
references.pmid: 21289607
references.citation: Curr Med Chem. 2013;20(8):976-83
references.pmid: 23210783
references.citation: Evid Based Complement Alternat Med. 2012;2012:802625
references.pmid: 22778778
references.citation: Brain Res. 2010 Aug 6;1347:149-60
references.pmid: 20573598
references.citation: Zhongguo Zhong Yao Za Zhi. 2011 Nov;36(22):3155-60
references.pmid: 22375398
references.citation: Life Sci. 2012 Oct 22;91(15-16):809-15
references.pmid: 22982182
references.citation: Neuroreport. 2007 May 7;18(7):689-92
references.pmid: 17426600
references.citation: Lancet Neurol. 2003 Sep;2(9):539-47
references.pmid: 12941576
references.citation: Zhongguo Zhong Yao Za Zhi. 2007 Jul;32(13):1336-9
references.pmid: 17879740
references.citation: Cell Biol Int. 2008 Feb;32(2):304-11
references.pmid: 18093848
references.citation: Neurobiol Aging. 2012 Dec;33(12):2903-19
references.pmid: 22459600
references.citation: J Neurosci. 2001 Nov 1;21(21):8370-7
references.pmid: 11606625
references.citation: J Neurosci Res. 2008 Aug 15;86(11):2432-40
references.pmid: 18438924
references.citation: J Pharm Pharmacol. 2007 Feb;59(2):301-9
references.pmid: 17270083
references.citation: J Ethnopharmacol. 2012 May 7;141(1):386-95
references.pmid: 22414474