title: Hypofibrinogenemia caused by adrenocorticotropic hormone for infantile spasms: a case report.
abstract: We report the case of a 7-month-old boy who developed hypofibrinogenemia (66.6 mg/dL; reference value, 170-405 mg/dL) during adrenocorticotropic hormone (ACTH) therapy for infantile spasms. Although the patient showed no clinical signs of a bleeding diathesis, we recommend that plasma fibrinogen levels should be monitored during ACTH therapy, which should be discontinued when fibrinogen levels fall below hemostatic levels (60.0mg/dL) or when bleeding tendencies are recognized.
authors.affiliation: Department of Pediatrics, Iwate Medical University School of Medicine, Morioka, Iwate, Japan. Electronic address: iz4a-kmi@asahi-net.or.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kamei
authors.affiliation: Department of Pediatrics, Iwate Medical University School of Medicine, Morioka, Iwate, Japan.
authors.forename: Nami
authors.initials: N
authors.lastname: Araya
authors.affiliation: Department of Pediatrics, Iwate Medical University School of Medicine, Morioka, Iwate, Japan.
authors.forename: Manami
authors.initials: M
authors.lastname: Akasaka
authors.affiliation: Department of Pediatrics, Iwate Medical University School of Medicine, Morioka, Iwate, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Mizuma
authors.affiliation: Department of Pediatrics, Iwate Medical University School of Medicine, Morioka, Iwate, Japan.
authors.forename: Maya
authors.initials: M
authors.lastname: Asami
authors.affiliation: Department of Pediatrics, Iwate Medical University School of Medicine, Morioka, Iwate, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tanifuji
authors.affiliation: Department of Pediatrics, Iwate Medical University School of Medicine, Morioka, Iwate, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Chida
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000009:adverse effects*; D000347:Afibrinogenemia / Q000139:chemically induced*; D000927:Anticonvulsants / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D013036:Spasms, Infantile / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D000324:Adrenocorticotropic Hormone
keywords: Adrenocorticotropic hormone therapy; Hypofibrinogenemia; Infantile spasms