title: Recognizing methylated histone variant H3.3 to prevent tumors.
abstract: Regulatory information stored in modified histones is functionally translated by effector proteins ('readers'), which identify the histone mark to determine the specificity of the response. A recent study identifying the tumor suppressor protein ZMYND11 as an exclusive reader of methylated histone variant H3.3, throws light on the role of transcription regulation in suppressing tumors.
authors.affiliation: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA.
authors.forename: Swaminathan
authors.initials: S
authors.lastname: Venkatesh
authors.affiliation: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA.
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Workman
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D002352:Carrier Proteins / Q000378:metabolism*; D005260:Female; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*; D061805:Transcription Elongation, Genetic
chemical_list: D002352:Carrier Proteins; D006657:Histones; D012319:RNA Polymerase II; D008239:Lysine
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