title: [Long-term survival in a case of recurrent gastrointestinal stromal tumor treated with intermittent or low-dose imatinib].
abstract: A 65-year-old woman with a gastrointestinal stromal tumor(GIST)underwent a total gastrectomy in 1999. In 2004, she was diagnosed with an intra-abdominal recurrence and was treated with 300mg/day of imatinib. Because of the side effects of imatinib, we interrupted the treatment and were forced to reduce the dose from 300mg/day to 100mg/day. However, at present, the tumor remains controlled. In conclusion, this case suggested that, even if given irregularly or at a low-dose, continuous treatment with imatinib might contribute to long-term survival in patients with GIST.
authors.affiliation: Dept. of Surgery, Seikeikai Chiba Medical Center.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kurata
authors.forename: Satoru
authors.initials: S
authors.lastname: Takaishi
authors.forename: Youichi
authors.initials: Y
authors.lastname: Sakuma
authors.forename: Koutarou
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nimura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tohma
authors.forename: Akiko
authors.initials: A
authors.lastname: Kagaya
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Matsubara
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001549:Benzamides / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D000068877:Imatinib Mesylate; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use*; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*; D012008:Recurrence; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate