title: Intraneuronal accumulation of Aβ42 induces age-dependent slowing of neuronal transmission in Drosophila.
abstract: Beta amyloid (Aβ42)-induced dysfunction and loss of synapses are believed to be major underlying mechanisms for the progressive loss of learning and memory abilities in Alzheimer's disease (AD). The vast majority of investigations on AD-related synaptic impairment focus on synaptic plasticity, especially the decline of long-term potentiation of synaptic transmission caused by extracellular Aβ42. Changes in other aspects of synaptic and neuronal functions are less studied or undiscovered. Here, we report that intraneuronal accumulation of Aβ42 induced an age-dependent slowing of neuronal transmission along pathways involving multiple synapses.
authors.affiliation: Department of Neurology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
authors.forename: Jing-Ya
authors.initials: JY
authors.lastname: Lin
authors.forename: Wen-An
authors.initials: WA
authors.lastname: Wang
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Liu
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Zhao
authors.forename: Fu-De
authors.initials: FD
authors.lastname: Huang
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D004331:Drosophila melanogaster; D004594:Electrophysiology; D004797:Enzyme-Linked Immunosorbent Assay; D009474:Neurons / Q000378:metabolism* / Q000473:pathology*; D010446:Peptide Fragments / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)
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