title: Spinal cord injury, immunodepression, and antigenic challenge.
abstract: The inability to effectively control microbial infection is a leading cause of morbidity and mortality in individuals affected by spinal cord injury (SCI). Available evidence from clinical studies as well as animal models of SCI demonstrate that increased susceptibility to infection is derived from disruption of central nervous system (CNS) communication with the host immune system that ultimately leads to immunodepression. Understanding the molecular and cellular mechanisms governing muted cellular and humoral responses that occur post-injury resulting in impaired host defense following infection is critical for improving the overall quality of life of individuals with SCI. This review focuses on studies performed using preclinical animal models of SCI to evaluate how injury impacts T and B lymphocyte responses following either viral infection or antigenic challenge.
authors.affiliation: Department of Molecular Biology & Biochemistry, University of California, Irvine 92697, United States; Reeve-Irvine Research Center, University of California, Irvine 92697, United States; Multiple Sclerosis Research Center, University of California, Irvine 92697, United States. Electronic address: held_kathy@allergan.com.
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Held
authors.affiliation: Department of Molecular Biology & Biochemistry, University of California, Irvine 92697, United States; Reeve-Irvine Research Center, University of California, Irvine 92697, United States; Multiple Sclerosis Research Center, University of California, Irvine 92697, United States; Division of Microbiology & Immunology Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States. Electronic address: tom.lane@path.utah.edu.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Lane
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D002490:Central Nervous System / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance; D056724:Immunity, Humoral; D007113:Immunity, Innate; D007156:Immunologic Memory; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D051379:Mice; D006517:Murine hepatitis virus / Q000276:immunology; D013119:Spinal Cord Injuries / Q000276:immunology* / Q000378:metabolism / Q000401:mortality / Q000821:virology; D016019:Survival Analysis
chemical_list: D000956:Antigens, Viral; D016207:Cytokines
keywords: Immune response; Immunologic memory; Infection; Spinal cord injury
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