title: Denaverine hydrochloride and carbetocin increased welfare during and after parturition and enhanced subsequent fertility in cattle.
abstract: The objectives of the current study were to investigate the influence of denaverine hydrochloride and carbetocin on softening and dilatation of the birth canal, the need for assistance during parturition, calf mortality, retention of fetal membranes, endometritis, and subsequent fertility. Altogether 200 animals (100 cows and 100 heifers) of the Simmental breed were divided into 2 groups: treatment (n = 100) and control (n = 100). Animals in the treatment group received denaverine hydrochloride and carbetocin (a maximum of twice for each, depending on the progression of labor) during delivery over a maximum of 4 waiting periods (30 min each), whereas control animals experienced the same waiting periods but received no treatment. The treatment protocol had a positive influence on the ease of calving and postpartum reproductive health. The treatment increased the number of animals with the birth canal dilated by more than 25 cm, and halved the need for any assistance at parturition. In addition, treatment decreased the occurrence of difficult calving, the need for episiotomy, the appearance of birth canal lesions, and clinical endometritis. The treatment protocol had an effect throughout the entire puerperal period, as treated animals conceived with fewer artificial inseminations (1.3 vs. 1.6 artificial inseminations/pregnancy) and sooner (67 vs. 78 d open) compared with control animals. Denaverine hydrochloride and carbetocin administered in combination during parturition affected the progression and ease of calving, and thus the welfare of cows in labor and subsequently. However, further studies are needed to confirm the findings and to establish best practices.
authors.affiliation: Department of Agriculture, Sisacko-Moslavacka County, A. i B. Radića 24, 44000 Sisak, Croatia.
authors.forename: Robert
authors.initials: R
authors.lastname: Zobel
authors.affiliation: Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, FI-04920 Saarentaus, Finland. Electronic address: juhani.taponen@helsinki.fi.
authors.forename: Juhani
authors.initials: J
authors.lastname: Taponen
mesh_terms: D000818:Animals; D001561:Benzilates / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases; D004716:Endometritis / Q000662:veterinary; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007315:Insemination, Artificial; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D036801:Parturition / Q000187:drug effects*; D049590:Postpartum Period; D011247:Pregnancy; D016896:Treatment Outcome
chemical_list: D001561:Benzilates; D010121:Oxytocin; C020731:carbetocin; C001967:denaverine
keywords: cattle; denaverine hydrochloride; parturition; welfare