title: Ribosomal RNA gene repeats, their stability and cellular senescence.
abstract: The ribosomal RNA gene (rDNA) repeats form a historically well-researched region in the chromosome. Their highly repetitive structure can be identified easily which has enabled studies on DNA replication, recombination, and transcription. The region is one of the most unstable regions in the genome because of deleterious recombination among the repeats. The ribosomal RNA gene repeats use a unique gene amplification system to restore the copy number after this has been reduced due to recombination. It has been shown that unstable features in the genome can accelerate cellular senescence that restricts the lifespan of a cell. Here, I will introduce a study by our group that shows how the stability of rDNA is maintained and affects lifespan. I propose that the ribosomal RNA gene repeats constitute a center from which the stability of the whole genome is regulated and the lifespan of the cell is controlled.
authors.affiliation: National Institute of Genetics, Division of Cytogenetics/Dept. of Genetics, The Graduate University for Advanced Studies, SOKENDAI.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000235:genetics*; D004275:DNA, Ribosomal / Q000235:genetics; D020459:Genes, rRNA / Q000235:genetics*; D006801:Humans; D020871:RNA Stability; D012335:RNA, Ribosomal / Q000737:chemistry* / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004275:DNA, Ribosomal; D012335:RNA, Ribosomal
references.citation: Curr Protoc Cell Biol. 2010 Dec;Chapter 22:Unit 22.14
references.pmid: 21154549
references.citation: Annu Rev Biochem. 1980;49:727-64
references.pmid: 6996571
references.citation: Genes Cells. 2011 Jun;16(6):617-24
references.pmid: 21605287
references.citation: Mol Cell. 2006 May 5;22(3):351-61
references.pmid: 16678107
references.citation: Genes Dev. 1999 Oct 1;13(19):2570-80
references.pmid: 10521401
references.citation: Annu Rev Genet. 1977;11:297-347
references.pmid: 339818
references.citation: Annu Rev Cell Biol. 1991;7:375-402
references.pmid: 1809350
references.citation: Genes Dev. 2003 Jun 15;17(12):1497-506
references.pmid: 12783853
references.citation: Nature. 2012 Feb 22;483(7388):218-21
references.pmid: 22367546
references.citation: Bioessays. 2008 Mar;30(3):267-72
references.pmid: 18293366
references.citation: Cell. 2004 May 14;117(4):441-53
references.pmid: 15137938
references.citation: Mol Cell. 2004 May 21;14(4):501-13
references.pmid: 15149599
references.citation: Curr Biol. 2003 Sep 2;13(17):1549-56
references.pmid: 12956959
references.citation: Genes Dev. 2002 Oct 1;16(19):2479-84
references.pmid: 12368258
references.citation: Mol Cell Biol. 2001 Jan;21(1):136-47
references.pmid: 11113188
references.citation: Science. 2005 Sep 2;309(5740):1581-4
references.pmid: 16141077
references.citation: Genes Dev. 1998 Dec 15;12(24):3821-30
references.pmid: 9869636
references.citation: Cell. 1985 Dec;43(2 Pt 1):405-13
references.pmid: 3907856
references.citation: Genes Genet Syst. 2011;86(3):141-9
references.pmid: 21952204
references.citation: Cell Mol Life Sci. 2011 Apr;68(8):1395-403
references.pmid: 21207101
references.citation: Mol Cell. 2004 Aug 13;15(3):409-21
references.pmid: 15304221
references.citation: Bioessays. 1991 Jul;13(7):317-22
references.pmid: 1759974
references.citation: Nature. 2011 Sep 21;477(7365):410-1
references.pmid: 21938058
references.citation: Tanpakushitsu Kakusan Koso. 2009 Mar;54(4 Suppl):537-42
references.pmid: 21089505
references.citation: Genomics. 1995 Apr 10;26(3):521-6
references.pmid: 7607675
references.citation: Genome Res. 2007 Feb;17(2):184-91
references.pmid: 17200233
references.citation: Mol Cell. 1999 Apr;3(4):447-55
references.pmid: 10230397
references.citation: Science. 2003 Mar 14;299(5613):1751-3
references.pmid: 12610228
references.citation: Mol Biol Evol. 2011 Oct;28(10):2883-91
references.pmid: 21546356
references.citation: Mech Ageing Dev. 2001 Jul 15;122(9):865-82
references.pmid: 11348655
references.citation: Science. 2010 Feb 5;327(5966):693-6
references.pmid: 20133573
references.citation: Mol Cell. 2009 Sep 11;35(5):683-93
references.pmid: 19748361
references.citation: Genomics. 1995 May 20;27(2):320-8
references.pmid: 7557999
references.citation: PLoS Genet. 2013 Apr;9(4):e1003410
references.pmid: 23593017
references.citation: Mol Cell Biol. 2003 Mar;23(5):1558-68
references.pmid: 12588976
references.citation: Curr Biol. 2013 Sep 23;23(18):1794-8
references.pmid: 23993840
references.citation: Genome Res. 2005 Aug;15(8):1079-85
references.pmid: 16024823
references.citation: Trends Biochem Sci. 1999 Nov;24(11):437-40
references.pmid: 10542411
references.citation: Nature. 2003 Nov 13;426(6963):194-8
references.pmid: 14608368
references.citation: J Bacteriol. 1982 Feb;149(2):458-68
references.pmid: 6173374
references.citation: Cancer Res. 2009 Dec 1;69(23):9096-104
references.pmid: 19920195