title: Pharmacokinetics of the individual enantiomer S-(+)-ketoprofen after intravenous and oral administration in dogs at two dose levels.
abstract: The pharmacokinetic of the individual S-(+)-enantiomer of ketoprofen, S-(+)-ketoprofen, after intravenous (IV) and oral (PO) administration was determined in six dogs at 1 and 3 mg/kg. Plasma concentrations were determined by high performance liquid chromatography with ultraviolet detection. The concentration-time curves were analyzed by non-compartmental methods. Steady-state volume of distribution (Vss) and clearance (Cl) of S-(+)-ketoprofen after IV administration were 0.22 ± 0.07 and 0.19 ± 0.03 L/kg, and 0.10 ± 0.02 and 0.09 ± 0.01 L/h/kg, at 1 and 3 mg/kg, respectively. Following PO administration, S-(+)-ketoprofen achieved maximum plasma concentrations of 4.91 ± 0.76 and 12.47 ± 0.62 μg/ml, at two dose levels, respectively. The absolute bioavailability after PO route was 88.66 ± 12.95% and 85.36 ± 13.90%, respectively.
authors.affiliation: Department of Pharmacology, Toxicology and Legal and Forensic Medicine, Faculty of Veterinary Medicine, University of Cordoba, Spain. Electronic address: jserranor@uco.es.
authors.forename: J M
authors.initials: JM
authors.lastname: Serrano-Rodríguez
authors.affiliation: Department of Pharmacology, Toxicology and Legal and Forensic Medicine, Faculty of Veterinary Medicine, University of Cordoba, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Serrano
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine. Francisco Santisteban Hospital, University of Cordoba, Spain.
authors.forename: J Morgaz
authors.initials: JM
authors.lastname: Rodríguez
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine. Francisco Santisteban Hospital, University of Cordoba, Spain.
authors.forename: M M Granados
authors.initials: MM
authors.lastname: Machuca
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine. Francisco Santisteban Hospital, University of Cordoba, Spain.
authors.forename: R J
authors.initials: RJ
authors.lastname: Gómez-Villamandos
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine. Francisco Santisteban Hospital, University of Cordoba, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Navarrete-Calvo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D018592:Cross-Over Studies; D004285:Dogs / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D007660:Ketoprofen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D013237:Stereoisomerism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen
keywords: Dogs; Intravenous; Oral; Pharmacokinetics; S-(+)-ketoprofen