Genetic diversity and haplotype structure of 24 Y-chromosomal STR in Chinese Hui ethnic group and its genetic relationships with other populations.
In the present study, 24 Y-chromosomal short tandem repeat (Y-STR) loci were analyzed in 115 unrelated Hui male individuals from Haiyuan county or Tongxin county, Ningxia Hui Autonomous Region, China, to evaluate the forensic application of the 24 STR loci and to analyze interpopulation differentiations by making comparisons between the Hui group data and previously published data of other 13 populations. A total of 115 different haplotypes were observed on these 24 Y-STR loci. The gene diversities ranged from 0.4049 (DYS437) to 0.9729 (DYS385a, b). The overall haplotype diversity was 1 at AGCU 24 Y-STR loci level, while the values were reduced to 0.999237, 0.996949, and 0.996644 at the Y-filer 17 loci, 11 Y-STR loci of extended haplotype and 9 Y-STR loci of minimal haplotype levels, respectively; whereas, haplotype diversity for additional 7 loci (not included in Y-filer 17 loci) was 0.995271. The pairwise FST , multidimensional scaling plot and neighbor-joining tree indicated the Hui group had the closest genetic relationship with Sala in the paternal lineage in the present study. In summary, the results in our study indicated the 24 Y-STRs had a high level of polymorphism in Hui group and hence could be a powerful tool for forensic application and population genetic study.
Shanghai Key Laboratory of Forensic Sciences, Institute of Forensic Sciences, Ministry of Justice, Shanghai, P. R. China; Xi'an Jiaotong University Health Science Center, Xi'an, P. R. China.
Bo-Feng
BF
Zhu
Yu-Dang
YD
Zhang
Wen-Juan
WJ
Liu
Hao-Tian
HT
Meng
Guo-Lian
GL
Yuan
Zhe
Z
Lv
Nan
N
Dong
Qiong
Q
Li
Chun-Hua
CH
Yang
Yu-Hong
YH
Zhang
Yin-Ling
YL
Hou
Li
L
Qian
Shuan-Liang
SL
Fan
Peng
P
Xu
D044466:Asian People / Q000235:genetics*; D002681:China; D041322:Chromosomes, Human, Y; D005006:Ethnicity / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation; D005828:Genetics, Population / Q000379:methods*; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010802:Phylogeny
D005819:Genetic Markers
AGCU Y24 STR; Chinese Hui group; Haplotype structure; Y-chromosomal STR