The heterogeneous mononuclear phagocyte system of the kidney.
The kidney has a diverse repertoire of cells that make up the mononuclear phagocyte system (MPS). Wu et al. identify a population of CD8αα+CD11c+MHC-II+ blood precursors that display dendritic cell-like characteristics in the glomeruli. These cells show increased recruitment in a rat anti-glomerular basement membrane glomerulonephritis model and were able to attenuate disease. This study highlights the importance of the MPS in kidney disease and the need to better understand it to develop immunotherapeutics translatable to the renal patient.
Department of Medicine, Imperial College London, London, UK.
Kevin J
KJ
Woollard
Department of Medicine, Imperial College London, London, UK.
Charles D
CD
Pusey
D019264:Adoptive Transfer; D000818:Animals; D015551:Autoimmunity; D039521:CD11c Antigen / Q000097:blood*; D017252:CD3 Complex / Q000097:blood*; D016827:CD8 Antigens / Q000097:blood*; D018414:CD8-Positive T-Lymphocytes / Q000637:transplantation*; D005260:Female; D005921:Glomerulonephritis / Q000517:prevention & control*; D000949:Histocompatibility Antigens Class II / Q000097:blood*; D007678:Kidney Glomerulus / Q000276:immunology*
D039521:CD11c Antigen; D017252:CD3 Complex; D016827:CD8 Antigens; C409469:CD8 antigen, alpha chain; D000949:Histocompatibility Antigens Class II