Quantitative muscle ultrasound and quadriceps strength in patients with post-polio syndrome.
BACKGROUND
We investigated whether muscle ultrasound can distinguish muscles affected by post-polio syndrome (PPS) from healthy muscles and whether severity of ultrasound abnormalities is associated with muscle strength.


METHODS
Echo intensity, muscle thickness, and isometric strength of the quadriceps muscles were measured in 48 patients with PPS and 12 healthy controls.


RESULTS
Patients with PPS had significantly higher echo intensity and lower muscle thickness than healthy controls. In patients, both echo intensity and muscle thickness were associated independently with muscle strength. A combined measure of echo intensity and muscle thickness was more strongly related to muscle strength than either parameter alone.


CONCLUSIONS
Quantitative ultrasound distinguishes healthy muscles from those affected by PPS, and measures of muscle quality and quantity are associated with muscle strength. Hence, ultrasound could be a useful tool for assessing disease severity and monitoring changes resulting from disease progression or clinical intervention in patients with PPS.
Department of Rehabilitation, Academic Medical Center, Postbus 22660, 1100 DD, Amsterdam, The Netherlands.
Alice
A
Bickerstaffe
Anita
A
Beelen
Machiel J
MJ
Zwarts
Frans
F
Nollet
Johannes P
JP
van Dijk
D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology*; D011051:Poliomyelitis / Q000473:pathology*; D052097:Quadriceps Muscle / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D014463:Ultrasonography
muscle fibers, muscle strength; neuromuscular diseases; post-poliomyelitis syndrome; skeletal; ultrasonography