2C-I-NBOMe, an "N-bomb" that kills with "Smiles". Toxicological and legislative aspects.
Substituted phenethylamines are a class of designer drugs that have recently emerged in the drug abuse market. Such substances remain legal to use, possess, and supply until these compounds become classified as scheduled. 2C-I-NBOMe or 25I-NBOMe is the N-benzyl-derivative of the iodo-substituted dimethoxy-phenethylamine (2C-I) that appeared recently in the drug market under the street name "N-Bomb". Due to its high potency, intoxications and fatal cases related to 2C-I-NBOMe use are increased worldwide. The use and trafficking of this substituted phenethylamine is banned only in some countries. A comprehensive review was performed using PubMed and Medline databases, together with additional non-peer reviewed information sources, including books and publications of state authorities in different countries, regarding chemistry, availability, pharmacology, and toxicology of 2C-I-NBOMe. Intoxications or lethal cases, published or reported, as well as the current legislation on this newly introduced drug are also reviewed.
Faculty of Medicine, Department of Forensic Medicine and Toxicology, National and Kapodistrian University of Athens , Athens , Greece.
Panagiota
P
Nikolaou
Ioannis
I
Papoutsis
Maria
M
Stefanidou
Chara
C
Spiliopoulou
Sotiris
S
Athanaselis
D015198:Designer Drugs / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D004118:Dimethoxyphenylethylamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D004335:Drug and Narcotic Control / Q000331:legislation & jurisprudence*; D006801:Humans; D015394:Molecular Structure; D015813:Substance Abuse Detection / Q000379:methods; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000401:mortality
D015198:Designer Drugs; D004118:Dimethoxyphenylethylamine; C554181:2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine
25I-NBOMe; 2C-I-NBOMe; N-Bomb; legislation; pharmacology; substituted phenethylamines; toxicology