[Acoustic radiation force impulse elastography for liver disease staging in human immunodeficiency virus and hepatitis C virus co-infection].
BACKGROUND
Survival of human immunodeficiency virus (HIV)-infected patients has improved due to the widespread use of anti-retroviral therapy. However, mortality has increased when HIV-infected patients are co-infected with hepatitis C virus (HCV), and the liver disease in such patients is rapidly progressive compared with that in HCV monoinfected patients. Therefore, accurate staging of the liver disease is critical when determining appropriate treatment.


OBJECTIVE
To clarify the efficacy of acoustic radiation force impulse (ARFI) elastography for the evaluation of liver fibrosis and hepatic functional reserve in HIV/HCV co-infected patients.


METHODS
The correlation of shear wave velocity (Vs), measured by ARFI elastography, with liver fibrosis or hepatic functional reserve was analyzed.


RESULTS
Vs was significantly correlated with platelet count, splenic volume, hyaluronic acid, type IV collagen, and LHL15 (receptor index: uptake ratio of the liver to the liver plus heart at 15min) in 99mTc-GSA (technetium-99m-diethylenetriaminepentaacetic acid-galactosyl human serum albumin) scintigraphy.


CONCLUSIONS
ARFI elastography was useful for the staging of liver disease in HIV/HCV co-infected patients and it facilitated minimally invasive and accessible evaluation of fibrosis and functional reserve.
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences.
Koji
K
Natsuda
Akihiko
A
Soyama
Mitsuhisa
M
Takatsuki
Tohei
T
Yamaguchi
Yasuhiro
Y
Torashima
Amane
A
Kitasato
Tomohiko
T
Adachi
Tamotsu
T
Kuroki
Tatsuki
T
Ichikawa
Kazuhiko
K
Nakao
Susumu
S
Eguchi
D000328:Adult; D060085:Coinfection / Q000150:complications*; D018450:Disease Progression; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005355:Fibrosis; D015658:HIV Infections / Q000150:complications*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D008111:Liver Function Tests / Q000379:methods*; D008875:Middle Aged