Expression of metabotropic glutamate receptors after hippocampal injury.
The expression of metabotropic glutamate receptors (mGluR2, mGluR3, mGluR4, and mGluR5) and dendritic cytoplasmic BC1 RNA in the hippocampus and frontal neocortex of Wistar rats was studied 1 and 4 weeks after intrahippocampal microinjection of kainic acid. The efficiency of glutamatergic transmission was shown to change not only in the injured hippocampus, but also in the neocortex. It was associated with variations in the expression of presynaptic (mGluR2, mGluR3, and mGluR4) and postsynaptic receptors (mGluR5).
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, Russia, viarkhipov@rambler.ru.
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Arkhipov
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Kapralova
D000818:Animals; D001930:Brain Injuries / Q000139:chemically induced / Q000378:metabolism*; D056654:CA3 Region, Hippocampal / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005625:Frontal Lobe / Q000378:metabolism / Q000503:physiopathology; D015870:Gene Expression; D007608:Kainic Acid; D008297:Male; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics / Q000378:metabolism*; D009435:Synaptic Transmission
C489663:Bc1 long-non-coding RNA, rat; D062085:RNA, Long Noncoding; D018094:Receptors, Metabotropic Glutamate; D007608:Kainic Acid