[A new indole alkaloid from the stems of Brucea mollis].
Eight compounds were isolated from the stems of Brucea mollis by various chromatographic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as bruceolline O (1), 1-(1-beta-glucopyranosyl)-1H-indole-3-carbaldehyde (2), canthin-6-one (3), 11-hydroxycanthin-6-one (4), 9-methoxycanthin-6-one (5), 4-methoxycanthin-6-one (6), infractin (7), and beta-carboline-1-propionic acid (8). The cytotoxic activities of compounds 1-8 against HCT-8 and A549 human cell lines were determined, but none of them exhibited significant activity (IC 50 > 10 micromol x L(-1)). Among them, compound 1 is a new indole alkaloid, and compounds 2 and 5-7 were isolated from this plant for the first time.
Hui
H
Chen
M A
MA
Shuang-Gang
Zhen-Feng
ZF
Fang
Gui-Jie
GJ
Zhang
Shi-Shan
SS
Yu
Xiao-Guang
XG
Chen
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032269:Brucea / Q000737:chemistry*; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D007769:Lactams
D000972:Antineoplastic Agents, Phytogenic; D002243:Carbolines; D026121:Indole Alkaloids; C459628:9-methoxycanthin-6-one; D007769:Lactams; C000604358:bruceolline O; C489105:drymaritin; C453379:canthin-6-one