Contributions of chondroitin sulfate proteoglycans to neurodevelopment, injury, and cancer.
Chondroitin sulfate proteoglycans (CSPGs) are a diverse family of extracellular matrix (ECM) molecules that make significant contributions to the patterning and routing of migrating neural cells and extending axons. Three distinct modes of migration mediation result from the relative abundance and positioning of expressed CSPGs, the profile of CSPG receptors expressed by the motile cell types, and the overall way in which the CSPGs integrate into and stabilize the neural ECM. Here we discuss recent findings that help to clarify the molecular mechanisms that underlie these distinct migration-regulating properties as they pertain to neural development, CNS injury, and gliomagenesis.
Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA 98109, United States.
Daniel J
DJ
Silver
Department of Neurosciences, Case Western Reserve University, 2109 Adelbert Road Rm E-658, Cleveland, OH 44106, United States. Electronic address: jxs10@case.edu.
Jerry
J
Silver
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D002490:Central Nervous System / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000378:metabolism*; D011508:Chondroitin Sulfate Proteoglycans / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism / Q000502:physiology
D011508:Chondroitin Sulfate Proteoglycans