Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning.
The olfactory bulb (OB) is one of the two major loci in the mammalian brain where newborn neurons are constantly integrated into the neural circuit during postnatal life. Newborn neurons are generated from neural stem cells in the subventricular zone (SVZ) of the lateral ventricle and migrate to the OB through the rostral migratory stream. The majority of these newborn neurons differentiate into inhibitory interneurons, such as granule cells and periglomerular cells. It has been reported that prolonged supply of newborn neurons leads to continuous addition/turnover of the interneuronal populations and contributes to functional integrity of the OB circuit. However, it is not still clear how and to what extent postnatal-born neurons contribute to OB neural circuit formation, and the functional role of postnatal neurogenesis in odor-related behaviors remains elusive. To address this question, here by using genetic strategies, we first determined the unique integration mode of newly born interneurons during postnatal development of the mouse OB. We then manipulated these interneuron populations and found that continuous postnatal neurogenesis in the SVZ-OB plays pivotal roles in flexible olfactory associative learning and memory.
Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan, Kyoto University Graduate School of Biostudies, Kyoto 606-8502, Japan, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan, New York University Neuroscience Institute, Department of Physiology and Neuroscience, Smilow Research Center, New York University School of Medicine, New York, New York 10016, Department of Basic Pathology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan, Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Kyoto 606-8507, Japan, World Premier International Research Initiative-Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 606-8501, Japan, Hakubi Center, Kyoto University, Kyoto 606-8507, Japan, and Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology, Kyoto 606-8507, Japan.
Masayuki
M
Sakamoto
Nao
N
Ieki
Goichi
G
Miyoshi
Daisuke
D
Mochimaru
Hitoshi
H
Miyachi
Tetsuya
T
Imura
Masahiro
M
Yamaguchi
Gord
G
Fishell
Kensaku
K
Mori
Ryoichiro
R
Kageyama
Itaru
I
Imayoshi
D000818:Animals; D001245:Association Learning / Q000502:physiology*; D002552:Cerebral Ventricles / Q000166:cytology / Q000502:physiology; D018891:Dentate Gyrus / Q000166:cytology / Q000254:growth & development / Q000502:physiology; D007395:Interneurons / Q000166:cytology / Q000502:physiology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009415:Nerve Net / Q000166:cytology / Q000502:physiology*; D058953:Neural Stem Cells / Q000166:cytology / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009812:Odorants; D009830:Olfactory Bulb / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D055696:Olfactory Perception / Q000502:physiology*
dentate gyrus; hippocampus; learning; neural stem cells; neurogenesis; olfactory bulb