Human herpes virus 8-unrelated primary effusion lymphoma-like lymphoma in a patient with hepatitis B virus-related liver cirrhosis: A case report.
This study describes a rare case of Human Immunodeficiency Virus and Human Herpes Virus 8 (HHV-8) negative primary effusion lymphoma (PEL)-like lymphoma in a patient with hepatitis B virus-related liver cirrhosis, diagnosed in a 66-year-old male who rapidly progressed to a sense of abdominal fullness. Cytological analysis of the pleural effusion demonstrated large atypical lymphoid cells with rounded nuclei, prominent nucleoli, and abundant cytoplasm. Immunocytochemistry of the pleural effusion detected atypical CD20(+) lymphoid cells. The patient was hospitalized, and died following sepsis and multi-organ failure. Our case highlights that HHV-8-unrelated PEL-like lymphoma patients have different pathogenetic mechanisms of causality at the biological level, immunophenotype, clinical behavior, and prognosis.
Department of Infectious Disease, The People's Liberation Army 161 Hospital, Wuhan, Hubei Province, China.
He-Bin
HB
Fan
Department of infectious diseases, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Dong-Liang
DL
Yang
Department of Pathology, The People's Liberation Army 161 Hospital, Wuhan, Hubei Province, China.
Yong
Y
Guo
Department of Infectious Disease, The People's Liberation Army 161 Hospital, Wuhan, Hubei Province, China.
An-Shen
AS
Chen
Department of Pathology, The People's Liberation Army 161 Hospital, Wuhan, Hubei Province, China.
Mu-Xiu
MX
Zhou
Department of Infectious Disease, The People's Liberation Army 161 Hospital, Wuhan, Hubei Province, China.
Juan-Juan
JJ
Wu
Department of Pathology, The People's Liberation Army 161 Hospital, Wuhan, Hubei Province, China.
Xiao-Ju
XJ
Ma
Department of Infectious Disease, The People's Liberation Army 161 Hospital, Wuhan, Hubei Province, China.
Zhi
Z
Li
Hepatitis B virus; human herpes virus 8; liver cirrhosis; primary effusion lymphoma