Speckle contrast optical tomography: A new method for deep tissue three-dimensional tomography of blood flow.
A novel tomographic method based on the laser speckle contrast, speckle contrast optical tomography (SCOT) is introduced that allows us to reconstruct three dimensional distribution of blood flow in deep tissues. This method is analogous to the diffuse optical tomography (DOT) but for deep tissue blood flow. We develop a reconstruction algorithm based on first Born approximation to generate three dimensional distribution of flow using the experimental data obtained from tissue simulating phantoms.
ICFO-Institut de Ciències Fotòniques, Av. Carl Friedrich Gauss, 3, 08860, Castelldefels (Barcelona), Spain ; These authors contributed equally to this work.
Hari M
HM
Varma
ICFO-Institut de Ciències Fotòniques, Av. Carl Friedrich Gauss, 3, 08860, Castelldefels (Barcelona), Spain ; These authors contributed equally to this work.
Claudia P
CP
Valdes
ICFO-Institut de Ciències Fotòniques, Av. Carl Friedrich Gauss, 3, 08860, Castelldefels (Barcelona), Spain.
Anna K
AK
Kristoffersen
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA ; Department of Physics, Washington University, St. Louis, MO 63130, USA.
Joseph P
JP
Culver
ICFO-Institut de Ciències Fotòniques, Av. Carl Friedrich Gauss, 3, 08860, Castelldefels (Barcelona), Spain.
Turgut
T
Durduran
(110.3010) Image reconstruction techniques; (110.6150) Speckle imaging; (110.6955) Tomographic imaging; (170.3880) Medical and biological imaging