Risk factors, lipid profile, and histopathological study of oral cancers in Kolar district: a case-control study.
OBJECTIVE
To estimate serum lipid profile in oral squamous cell carcinoma and correlate the risk factors and lipid profile with oral squamous cell carcinoma.


METHODS
Lipid profile was done in agriculturists/laborers in the age group of 30-70 years; 56 subjects (cases = 28, control = 28) were included. Study was carried out for a duration of four months; statistical analyses applied were mean, standard deviation, and independent 't' test. P < 0.05 was considered statistically significant.


RESULTS
Eleven cases had buccal mucosa cancer, nine had tongue carcinoma, and eight had gingivobuccal sulcus carcinoma. Lipid profile such as total cholesterol, triglycerides, LDL cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, and very-low-density lipoprotein (VLDL) were marginally and slightly elevated in cases compared to controls. HDL was grossly decreased in cases compared to controls.


CONCLUSIONS
There was a significant association between HDL and squamous cell carcinoma; maximum number of SCC had a history of smoking in the range of 10-19 years, irrespective of other lipid parameters, constrained to the fact that lipids are genetically determined, have geographical variation, and are highly skewed.
Amith
A
Kamath
Kurpad Nagaraj
KN
Shashidhar
Department of Pathology, Sri Devaraj Urs Medical, College, Tamaka, Kolar, Karnataka, India.
Hemalatha
H
Anantharamaiah
Harish
H
Rangareddy
Vinaya Babu
VB
Sathyanarayana
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007194:India; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood* / Q000473:pathology*; D060787:Neoplasm Grading; D012307:Risk Factors; D014026:Nicotiana / Q000009:adverse effects
D008055:Lipids