Radical ipso-substitution of a carbon-fluorine bond leading to fluoro-7-azaindolines and fluoro-7-azaindoles.
Rare examples of a synthetically useful radical ipso-substitution of a carbon-fluorine bond are reported, leading to highly functionalized 5,6-difluoro-7-azaindolines. An unexpected hydrogen atom translocation and fragmentation with loss of molecular nitrogen and formation of a nitrile were observed in the case of an N-benzyl-tetrazole derivative.
Laboratoire de Synthèse Organique, UMR 7652 CNRS/Ecole Polytechnique, 91128 Palaiseau Cedex, France.
Zhibo
Z
Liu
Ling
L
Qin
Samir Z
SZ
Zard