One-pot synthesis of 2-substituted benzo[b]furans via Pd-tetraphosphine catalyzed coupling of 2-halophenols with alkynes.
A catalyst composed of [Pd(η(3)-C3H5)Cl]2 and N,N,N',N'-tetra(diphenylphosphinomethyl)pyridine-2,6-diamine (L) was found to be effective for one-pot synthesis of 2-substituted benzo[b]furans from 2-halophenols and alkynes. For 2-bromo-3-hydroxypyridine, the catalyst loading could be as low as 1 ppm and the turnover number (TON) was up to 870,000.
Key Lab of Green Chemistry and Technology, Ministry of Education, Sichuan University, Chengdu, China. liruixiang@scu.edu.cn.
Rong
R
Zhou
Wei
W
Wang
Zhi-jie
ZJ
Jiang
Kun
K
Wang
Xue-li
XL
Zheng
Hai-yan
HY
Fu
Hua
H
Chen
Rui-xiang
RX
Li
D000480:Alkynes / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis*; D002384:Catalysis; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*
D000480:Alkynes; D001572:Benzofurans; D009942:Organometallic Compounds; D010636:Phenols; D010720:Phosphines; D010165:Palladium