Decreased interleukin-10 serum levels in first-episode drug-naïve schizophrenia: relationship to psychopathology.
Many lines of findings support the hypothesis of the inflammation-related pathways in the multifactorial pathogenesis of schizophrenia (SZ). Interleukin-10 (IL-10), a potential anti-inflammatory cytokine, was found to be altered in chronic patients with SZ. The aim of this study was to assess the serum levels of IL-10 in first-episode and drug-naïve (FEDN) patients with SZ and its relationships with the psychopathological parameters. Serum IL-10 levels were analyzed using established procedures in 128 FEDN patients with SZ and 62 healthy controls. Schizophrenia symptoms were assessed by the Positive and Negative Syndrome Scale (PANSS) with cognitive factor derived from the five factor model of the PANSS. Compared to the healthy controls, the patients exhibited a significant decrease in IL-10 levels. Serum IL-10 was inversely correlated with the PANSS negative symptom, as well as with the PANSS cognitive factor subscores in patients. Our results suggested that decreased IL-10 may be implicated in the negative symptom and cognitive impairment at the acute stage of schizophrenia episode.
Biological Psychiatry Center, Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
Mei Hong
MH
Xiu
Biological Psychiatry Center, Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
Gui Gang
GG
Yang
Biological Psychiatry Center, Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
Yun Long
YL
Tan
Biological Psychiatry Center, Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
Da Chun
DC
Chen
Biological Psychiatry Center, Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
Shu Ping
SP
Tan
Biological Psychiatry Center, Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
Zhi Ren
ZR
Wang
Biological Psychiatry Center, Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
Fu De
FD
Yang
Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Olaoluwa
O
Okusaga
Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jair C
JC
Soares
Biological Psychiatry Center, Beijing HuiLongGuan Hospital, Peking University, Beijing, China; Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: zhangxy9@gmail.com.
Xiang Yang
XY
Zhang
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000209:etiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011599:Psychopathology; D012559:Schizophrenia / Q000097:blood* / Q000150:complications; D012565:Schizophrenic Psychology; D013223:Statistics as Topic; D055815:Young Adult
D016753:Interleukin-10
Cognition; Cytokines; Immune function; Interleukin-10; Psychopathology; Schizophrenia