Early small vessel disease affects frontoparietal and cerebellar hubs in close correlation with clinical symptoms--a resting-state fMRI study.
Cerebral small vessel disease, mainly characterized by white matter lesions and lacunes, has a high clinical impact as it leads to vascular dementia. Recent studies have shown that this disease impairs frontoparietal networks. Here, we apply resting-state magnetic resonance imaging and data-driven whole-brain imaging analysis methods (eigenvector centrality) to investigate changes of the functional connectome in early small vessel disease. We show reduced connectivity in frontoparietal networks, whereas connectivity increases in the cerebellum. These functional changes are closely related to white matter lesions and typical neuropsychological deficits associated with small vessel disease.
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Alexander
A
Schaefer
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Eva M
EM
Quinque
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Judy A
JA
Kipping
1] Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany [2] Leipzig Research Center for Civilization Diseases, University Leipzig, Leipzig, Germany [3] Clinic of Cognitive Neurology, University Leipzig, Leipzig, Leipzig, Germany.
Katrin
K
Arélin
1] Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany [2] Clinic of Cognitive Neurology, University Leipzig, Leipzig, Leipzig, Germany [3] Integrated Research and Treatment Center Adiposity Diseases, University Leipzig, Leipzig, Germany.
Elisabeth
E
Roggenhofer
1] Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany [2] Department of Neurology, J. W. Goethe University, Frankfurt am Main, Germany.
Stefan
S
Frisch
1] Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany [2] Leipzig Research Center for Civilization Diseases, University Leipzig, Leipzig, Germany [3] Clinic of Cognitive Neurology, University Leipzig, Leipzig, Leipzig, Germany [4] Berlin School of Mind and Brain, Mind and Brain Institute, Berlin, Germany [5] Center for Stroke Research, Charité Universitätsmedizin, Berlin, Germany.
Arno
A
Villringer
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Karsten
K
Mueller
1] Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany [2] Leipzig Research Center for Civilization Diseases, University Leipzig, Leipzig, Germany [3] Clinic of Cognitive Neurology, University Leipzig, Leipzig, Leipzig, Germany [4] German Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany.
Matthias L
ML
Schroeter
D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D002561:Cerebrovascular Disorders / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology*