Bioaccumulation and elimination kinetics of hydroxylated polybrominated diphenyl ethers (2'-OH-BDE68 and 4-OH-BDE90) and their distribution pattern in common carp (Cyprinus carpio).
Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) have attracted wide concerns due to their toxicities and universal presence in wildlife and humans. The relatively high Kow values of OH-PBDEs imply these compounds may have a significant bioaccumulation potential, but so far, the existing data provide little information regarding the kinetics of uptake and depuration in any organisms. Here we exposed common carps separately to two OH-PBDEs, 2'-OH-BDE68 and 4-OH-BDE90, for 30 days (d) in a flow-through system, followed by a 60-d depuration period in clean water to investigate compound-specific bioaccumulation and tissue distribution. Two OH-PBDEs could accumulate in common carp, and the high concentration was observed in liver or kidney. The uptake rates (k1) of two OH-PBDEs ranged from 0.15 to 21.3 d(-1) in fish, and the elimination rates (k2) ranged from 0.027 to 0.075 d(-1), which leaded to their BCF values in 4.8-299.2 ranges. Half-lives ranged from 9.2 d to 25.6 d. The exposure concentration significantly affected BCF values but didn't change their relative compositions in liver, kidney and muscle after a long exposure time. To our knowledge, this is the first study to systematically assess uptake, depuration kinetics and tissue distribution for OH-PBDEs via a controlled experimental animal model.
Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China. Electronic address: hxzhao@dlut.edu.cn.
Hongxia
H
Zhao
Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.
Guolong
G
Zhang
Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.
Sisi
S
Liu
Dalian Institute of Product Quality Supervision & Inspection, Dalian 116021, China.
Baocheng
B
Qu
Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.
Yanli
Y
Wang
Department of Civil and Environmental Engineering, 4105 Seamans Center, University of Iowa, Iowa City, IA 52242, USA.
Dingfei
D
Hu
Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.
Jingqiu
J
Jiang
Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.
Xie
X
Quan
Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.
Jingwen
J
Chen
D000818:Animals; D002347:Carps / Q000378:metabolism*; D055768:Halogenated Diphenyl Ethers / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics*
C561157:2'-hydroxy-2,3',4,5'-tetrabromodipheyl ether; D055768:Halogenated Diphenyl Ethers; D014874:Water Pollutants, Chemical
Bioconcentration; Common carp; Distribution; OH-PBDEs