Hypolipidic diet and phytosubstance supplement in hypercholesterolemia.
OBJECTIVE
This study aimed to evaluate the effects of phyto-supplements on hyperlipidemia.


METHODS
For this study 191 patients, affected by hyperlipidemia, attending the Outpatient Clinics of Clinical Medicine Department, were recruited. The patients were divided in two groups. The first group (80) has been treated with hypolipidic diet for six months (group D). The second one (111) has been administered with hypolipidic diet and supplement (red yeast, guggulsterones, flavonoid, sylimarin) (group E). Anthropometric measurements and bioimpedance analysis were evaluated before and after treatment. Moreover, total cholesterol, LDL, HDL, triglycerides (TG) and hepatic transaminases (AST, ALT) were measured before, after 3 and 6 months of treatment.


RESULTS
D group showed a significant reduction in BMI (32.6 ± 0.7 vs. 34.3 ± 0.7 kg/m²), waist circumference (104.4 ± 1.6 vs. 108.3 ± 1.5 cm), hip circumference (107.9 ± 1.1 vs. 111.2 ± 1.1 cm), total cholesterol (214.2 ± 3.7 vs. 236.6 ± 2.2 mg/dL, -9.4 ± 68.2%), LDL cholesterol (133 ± 3 vs. 152.9 ± 2.8 mg/dL, -13 ± 7.1%). E group showed a significant reduction in BMI (30.2 ± 0.7 vs. 32.6 ± 0.6 kg/m²), waist circumference (94.5 ± 1.6 vs. 101.3 ± 1.3 cm), hip circumference (106.6 ± 1.1 vs. 110.5 ± 1 cm), total cholesterol (212.4 ± 3.7 vs. 256.9 ± 2.1 mg/dL, -17.3 ± 76.2%), LDL cholesterol (133.4 ± 3.4 vs. 168.4 ± 2.3 mg/dL, -20.8 ± 47.8%).


CONCLUSIONS
Low fat diet, associated to phyto-substance supplement, have been proven useful to decrease serum cholesterol level and to improve nutritional status.
Clinical Medicine and Surgery "Federico II" University, Naples, Italy - espedita.muscariello@unina.it.
E
E
Muscariello
G
G
Nasti
R
R
Battinelli
T
T
Novellino
M
M
Montisano
A
A
Colantuoni
D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004038:Diet, Reducing; D019587:Dietary Supplements; D017097:Electric Impedance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D008517:Phytotherapy / Q000379:methods; D000637:Transaminases / Q000097:blood; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D015431:Weight Loss
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol; D000637:Transaminases