Avidity of antibodies against infecting pneumococcal serotypes increases with age and severity of disease.
The incidence of invasive pneumococcal disease (IPD) rises with age. Among adult IPD patients, the avidity of antipneumococcal polysaccharide antibodies against the infecting serotype increased with age and severity of disease, indicating that susceptibility to IPD in the elderly may rather be due to flaws in other aspects of opsonophagocytosis.
Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands Amelieke.Cremers@radboudumc.nl.
Amelieke J H
AJ
Cremers
Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands.
Jonneke
J
Lut
Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands.
Peter W M
PW
Hermans
Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands.
Jacques F
JF
Meis
Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands.
Marien I
MI
de Jonge
Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands.
Gerben
G
Ferwerda
D000375:Aging; D000907:Antibodies, Bacterial / Q000276:immunology*; D000915:Antibody Affinity / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology*; D011008:Pneumococcal Infections / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000276:immunology; D012720:Severity of Illness Index; D013296:Streptococcus pneumoniae / Q000276:immunology
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D011135:Polysaccharides, Bacterial