Motility and trafficking in B-cell non-Hodgkin's lymphoma (Review).
B cell non-Hodgkin's lymphomas (B-NHLs) consist of a wide spectrum of entities and consequently have varied clinical courses. Like many other malignancies, each of the B-NHL depend on their microenvironment for growth and survival; therefore, understanding the factors involved in their tissue localisation is likely to have implications for therapies designed to treat B-NHL. This review summarises the chemokines, integrins and sphingosine-1 phosphate receptors involved in normal B cell location and distribution within the lymphoid tissues (lymph nodes, spleen and bone marrow). It also provides a précis of what is known about these factors in the disease state: i.e., in some subtypes of B-NHL.
Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3GA, UK.
Kathleen J
KJ
Till
Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3GA, UK.
Sarah E
SE
Coupland
Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3GA, UK.
Andrew R
AR
Pettitt
D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D002465:Cell Movement; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000473:pathology*; D019707:Receptors, Chemokine / Q000378:metabolism; D049349:Receptors, Lysosphingolipid / Q000378:metabolism; D013154:Spleen / Q000276:immunology / Q000473:pathology
D016023:Integrins; D019707:Receptors, Chemokine; D049349:Receptors, Lysosphingolipid