Clinical superficial Raman probe aimed for epithelial tumor detection: Phantom model results.
A novel clinical Raman probe for sampling superficial tissue to improve in vivo detection of epithelial malignancies is compared to a non-superficial probe regarding depth response function and signal-to-noise ratio. Depth response measurements were performed in a phantom tissue model consisting of a polyethylene terephthalate disc in an 20%-Intralipid(®) solution. Sampling ranges of 0-200 and 0-300 μm were obtained for the superficial and non-superficial probe, respectively. The mean signal-to-noise ratio of the superficial probe increased by a factor of 2 compared with the non-superficial probe. This newly developed superficial Raman probe is expected to improve epithelial cancer detection in vivo.
Department of Medical Physics & Instrumentation, St. Antonius Hospital, PO Box 2500, 3430 EM Nieuwegein, The Netherlands ; Department of Urology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Michelle
M
Agenant
Department of Medical Physics & Instrumentation, St. Antonius Hospital, PO Box 2500, 3430 EM Nieuwegein, The Netherlands.
Matthijs
M
Grimbergen
Department of Urology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Ronald
R
Draga
EmVision LLC, 1471 F Road, Loxahatchee, Florida 33470, USA.
Eric
E
Marple
Department of Urology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Ruud
R
Bosch
Department of Medical Physics & Instrumentation, St. Antonius Hospital, PO Box 2500, 3430 EM Nieuwegein, The Netherlands.
Christiaan
C
van Swol
(170.3890) Medical optics instrumentation; (170.5660) Raman spectroscopy; (300.6450) Spectroscopy, Raman