Validity and reliability of the neuropsychiatric inventory questionnaire version in patients with stroke or transient ischemic attack having cognitive impairment.
This study examined the validity and reliability of the Neuropsychiatric Inventory Questionnaire version (NPI-Q), a proxy-reported format of the interview-based NPI, in assessing neuropsychiatric symptoms in 173 patients with stroke or transient ischemic attack (TIA) having cognitive impairment. The NPI-Q was validated against the NPI as a gold standard. Informants took approximately 7 minutes to complete the NPI-Q. Bland-Altman analysis revealed a bias of 0.7 points, with 95% limits of agreement between -8.6 and 10.0 between the total symptom scores of the NPI and NPI-Q. The NPI-Q correlated significantly with the NPI in individual and total symptom scores and caregiver distress scores. In predicting presence of symptoms on the NPI, the NPI-Q yielded, on average, sensitivity of 74.1% and specificity of 79.5%. On the NPI-Q, informants tended to overreport symptoms in patients with less severe symptoms but underreport with increasing symptom severity. Internal consistency of the NPI-Q was acceptable (Cronbach's α = 0.756). One-week test-retest reliability of the NPI-Q was excellent (intraclass correlation coefficient = .990). The NPI-Q is a valid and reliable instrument for screening neuropsychiatric symptoms in patients with stroke and TIA.
Department of Psychological Studies, The Hong Kong Institute of Education, Tai-po, Hong Kong SAR, China Center for Psychosocial Health and Aging, The Hong Kong Institute of Education, Tai-po, Hong Kong SAR, China.
Adrian
A
Wong
Department of Health and Physical Education, The Hong Kong Institute of Education, Tai-po, Hong Kong SAR, China.
Sheung-Tak
ST
Cheng
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Eugene S K
ES
Lo
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Pauline W L
PW
Kwan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Lorraine S N
LS
Law
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Anne Y Y
AY
Chan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Lawrence Ka-Sing
LK
Wong
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China vctmok@cuhk.edu.hk.
Vincent
V
Mok
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D017028:Caregivers / Q000523:psychology*; D003071:Cognition; D060825:Cognitive Dysfunction / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000523:psychology*; D007802:Language; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards*; D011594:Psychometrics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020521:Stroke / Q000523:psychology*; D011795:Surveys and Questionnaires / Q000592:standards*; D014175:Translating
behavioral and psychological symptoms of dementia; clinical assessment; neuropsychiatric inventory questionnaire; stroke; vascular cognitive impairment; vascular dementia