The effect of resveratrol on surgery-induced epidural fibrosis in laminectomy rats.
Epidural fibrosis (EF) is a common complication for the patients who underwent laminectomy. Recently, EF is thought to cause recurrent postoperative pain after laminectomy. Resveratrol has been shown to exert its anti-inflammatory, antifibrotic, and antiproliferative multifaceted properties. The object of this study was to investigate the effects of resveratrol on the prevention of postlaminectomy EF formation in laminectomy rats. A controlled double-blinded study was performed on 60 healthy adult Sprague-Dawley rats that underwent lumbar laminectomy at the L1-L2 levels. They were divided randomly into 3 groups (1, 2, and 3) of 20 rats each-group 1: resveratrol treatment group; group 2: resveratrol dilution saline treatment group; group 3: sham group (rats underwent laminectomy without treatment). All rats were killed 4 weeks after operation. The Rydell score, hydroxyproline content, vimentin cells density, fibroblasts density, and inflammatory factors expressional levels all suggested better results in resveratrol group than the other two groups. Resveratrol is able to inhibit fibroblasts proliferation, and TGF- β 1 and IL-6 expressions and prevent epidural fibrosis in postlaminectomy rat.
Shandong University, Jinan 250100, China ; Department of Orthopedics, Chinese People's Liberation Army 401 Hospital, Tsingtao, Shandong 266071, China.
Peifeng
P
Sun
Department of Orthopedic Trauma & Hand and Foot Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan 250100, China.
Bo
B
Miao
Qilu Hospital of Shandong University, Tsingtao 266010, China.
Hongmei
H
Xin
Department of Orthopedics, Chinese People's Liberation Army 401 Hospital, Tsingtao, Shandong 266071, China.
Jinzhu
J
Zhao
Department of Orthopedics, Chinese People's Liberation Army 401 Hospital, Tsingtao, Shandong 266071, China.
Guofeng
G
Xia
Department of Orthopedics, Chinese People's Liberation Army 401 Hospital, Tsingtao, Shandong 266071, China.
Peng
P
Xu
Department of Orthopedics, Chinese People's Liberation Army 401 Hospital, Tsingtao, Shandong 266071, China.
Jian
J
Hu
Qilu Hospital of Shandong University, Jinan 250012, China.
Zhenfeng
Z
Li
Qilu Hospital of Shandong University, Jinan 250012, China.
Jianmin
J
Li