Far-red and near infrared BODIPY dyes: synthesis and applications for fluorescent pH probes and bio-imaging.
Far-red and near infrared (NIR) emissive dyes have advantages in the development of fluorescent probes and labelling for bio-imaging in living systems since fluorescence in the long-wavelength region would generate minimum photo-toxicity to biological components, deep tissue penetration and minimal background from auto-fluorescence by bio-molecules. BODIPY dyes are attractive due to their excellent photo-physical properties and potential for fluorescence-based sensing and bio-imaging applications. Thus, numerous research papers have emerged to develop BODIPY-based dyes with absorption and emission in the long-wavelength spectral region (650-900 nm). This review summarizes the general strategies to obtain far-red and NIR BODIPYs. Moreover, their applications for fluorescent pH probes and imaging or labelling in living systems are highlighted.
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore. chmwuj@nus.edu.sg.
Yong
Y
Ni
Jishan
J
Wu
D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D006863:Hydrogen-Ion Concentration; D021621:Imaging, Three-Dimensional; D007211:Indoles / Q000737:chemistry; D019265:Spectroscopy, Near-Infrared
C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D004952:Esters; D005456:Fluorescent Dyes; D007211:Indoles; C098209:VPM chloride