Effects of 3-hydroxypyridine derivatives and succinic acid on endometrial leukocyte infiltration, cytokinemia and related affective symptoms during exacerbation of the chronic inflammation of the uterus and adnexa.
We studied the effects of original Russian derivatives of 3-hydroxypyridine and succinic acid (emoxipine, reamberin and mexidol) on the time course of endometrial leukocyte infiltration, blood levels of inflammatory cytokines (IL-1β and TNF-α), and indicators of affective status in women with exacerbation of the chronic inflammation of the uterus and adnexa. It was found that emoxipine, reamberin, and mexidol included in the complex therapy corrects anxiety and depressive disorders depending on the degree of reduction of endometrial leukocyte infiltration and blood levels of inflammatory cytokines. Derivatives of 3-hydroxypyridine (emoxipine and mexidol) exhibited efficiency, which were superior to derivative of succinic acid (reamberin) in the degree of reduction in endometrial leukocyte and neutrophyl infiltration and in severity of anxiety and depressive disorders. Mexidol, a 3-hydroxypyridine and succinic acid derivative, was most effective and surpassed emoxipine by the degree of reduction of inflammatory cytokine level in the blood and the severity of affective anxiety symptoms in women with exacerbation of the chronic inflammation of the uterus and adnexa.
Department of Pharmacology, Chelyabinsk State Medical Academy, Ministry of the Health of Russian Federation, Chelyabinsk, Russia, volcheg@yandex.ru.
I A
IA
Volchegorskii
E V
EV
Pravdin
T V
TV
Uzlova
D000291:Adnexal Diseases / Q000473:pathology*; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood*; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D007962:Leukocytes / Q000378:metabolism*; D011725:Pyridines / Q000494:pharmacology / Q000627:therapeutic use*; D016037:Single-Blind Method; D019802:Succinic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D014591:Uterine Diseases / Q000473:pathology*
D016207:Cytokines; D011725:Pyridines; C023500:3-hydroxypyridine; D019802:Succinic Acid