Manifestation of cystic fibrosis transmembrane regulator (CFTR) in hepatic ductal structures and renal tubules of female rats with experimental cholestasis of pregnancy.
Studies by the immunohistochemical method with semiquantitative analysis of images showed that hyperprolactinemia stimulated CFTR protein manifestation in the bile ducts of female rats, which was clearly expressed in experimental cholestasis of pregnancy. The expression of CFTR in the renal tubules was reduced in hyperprolactinemia under conditions of normal liver function and in cholestasis of pregnancy. Significant positive correlations between CFTR, prolactin receptor, and multiple drug resistance protein 3 were detected in the bile ducts, but not in the renal tubules. Presumably, prolactin has a direct effect on CFTR expression in the bile ducts and indirect effect in the renal tubules. Changes in CFTR protein manifestation in the hepatic ductal structures and renal tubules in experimental pregnancy cholestasis could aggravate the disease.
Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia, amigola@yandex.ru.
M I
MI
Aleksandrova
N S
NS
Kushnareva
O V
OV
Smirnova
D000818:Animals; D021461:Animals, Outbred Strains; D002780:Cholestasis, Intrahepatic / Q000378:metabolism* / Q000473:pathology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism*; D005260:Female; D006500:Hepatic Duct, Common / Q000378:metabolism* / Q000473:pathology; D007684:Kidney Tubules / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011981:Receptors, Prolactin / Q000378:metabolism
C579654:CFTR protein, rat; D011981:Receptors, Prolactin; D019005:Cystic Fibrosis Transmembrane Conductance Regulator