Persistent lipid abnormalities in patients with hypertension and dyslipidemia treated with statins: results of the Portuguese hypertensive subpopulation of the Dyslipidemia International Study (DYSIS).
This study aimed to assess the treatment patterns and prevalence of persistent lipid abnormalities in Portuguese hypertensive patients concomitantly treated with statins. Only 25% of the 656 hypertensive patients achieved the blood pressure goals in use during the study period. Similarly, only 33% and 37% attained the recommended levels of total cholesterol<4.5 mmol/L and LDL cholesterol<2.5 mmol/L, respectively. Relatively low doses of medium potency statins were the mainstay of therapy. There seems to be considerable room for improvement through the use of more potent statins, dose up-titration, and/or addition of other lipid-modifying therapies.
Hospital Santa Marta, Internal Medicine 4 , Lisbon , Portugal .
Pedro M
PM
Silva
Salvador M
SM
Cardoso
Antonio M
AM
Ferreira
D000368:Aged; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011174:Portugal / Q000453:epidemiology; D015995:Prevalence; D011322:Primary Prevention / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D055502:Secondary Prevention / Q000379:methods
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids
Cardiovascular disease; HMG-CoA; dyslipidemia; hypertension; simvastatin; statins