Polymeric nanomicelles for sustained delivery of anti-cancer drugs.
In the first section of this paper, the existing and emerging nanotechnology-based cancer therapies--nanoparticles, drug conjugates, nanomicelles--are reviewed. In a second part, we present our original and unpublished findings on the sustained release of anti-cancer drugs such as paclitaxel, doxorubicin and camptothecin using block copolymer micelles [PEG-b-poly(dioxanone-co-methyl dioxanone)]. Copolymers with variable lengths of hydrophobic and hydrophilic blocks have been synthesized and successfully loaded with paclitaxel, doxorubicin and camptothecin anti-cancer drugs, with micelles size in the range 130-300 nm. Drug encapsulation efficiencies varied between 15% and 70% depending on drug and copolymer composition. The drug binding constants, which give a good insight into drug encapsulation and release, were evaluated from UV spectroscopy as we reported previously for anti-TB drugs. Through variation of the methyl dioxanone content of the copolymer, our systems can be tailored for sustained release of the different drugs.
ANDI Centre of Excellence for Biomedical and Biomaterials Research, University of Mauritius, MSIRI Building, Réduit, Mauritius.
Roubeena
R
Jeetah
ANDI Centre of Excellence for Biomedical and Biomaterials Research, University of Mauritius, MSIRI Building, Réduit, Mauritius.
Archana
A
Bhaw-Luximon
ANDI Centre of Excellence for Biomedical and Biomaterials Research, University of Mauritius, MSIRI Building, Réduit, Mauritius. Electronic address: djhurry@uom.ac.mu.
Dhanjay
D
Jhurry
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008823:Micelles; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016687:Polydioxanone / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D008823:Micelles; D016687:Polydioxanone; D011092:Polyethylene Glycols
Anti-cancer; Camptothecin; Doxorubicin; Paclitaxel; Polymeric micelles; Sustained delivery