An association of genotypes and antimicrobial resistance patterns among Salmonella isolates from pigs and humans in Taiwan.
We collected 110 Salmonella enterica isolates from sick pigs and determined their serotypes, genotypes using pulsed-field gel electrophoresis (PFGE), and antimicrobial susceptibility to 12 antimicrobials and compared the data with a collection of 18,280 isolates obtained from humans. The pig isolates fell into 12 common serovars for human salmonellosis in Taiwan; S. Typhimurium, S. Choleraesuis, S. Derby, S. Livingstone, and S. Schwarzengrund were the 5 most common serovars and accounted for a total of 84% of the collection. Of the 110 isolates, 106 (96%) were multidrug resistant (MDR) and 48 (44%) had PFGE patterns found in human isolates. S. Typhimurium, S. Choleraesuis, and S. Schwarzengrund were among the most highly resistant serovars. The majority of the 3 serovars were resistant to 8-11 of the tested antimicrobials. The isolates from pigs and humans sharing a common PFGE pattern displayed identical or very similar resistance patterns and Salmonella strains that caused severe infection in pigs were also capable of causing infections in humans. The results indicate that pigs are one of the major reservoirs to human salmonellosis in Taiwan. Almost all of the pig isolates were MDR, which highlights the necessity of strictly regulating the use of antimicrobials in the agriculture sector in Taiwan.
Department of Veterinary Medicine, National Chiayi University, Chiayi, Taiwan.
Hung-Chih
HC
Kuo
National Health Research Institutes, Miaoli, Taiwan.
Tsai-Ling
TL
Lauderdale
Department of Veterinary Medicine, National Chiayi University, Chiayi, Taiwan.
Dan-Yuan
DY
Lo
Department of Veterinary Medicine, National Chiayi University, Chiayi, Taiwan.
Chiou-Lin
CL
Chen
National Health Research Institutes, Miaoli, Taiwan.
Pei-Chen
PC
Chen
Centers for Disease Control, Taichung, Taiwan.
Shiu-Yun
SY
Liang
Centers for Disease Control, Taichung, Taiwan.
Jung-Che
JC
Kuo
Centers for Disease Control, Taichung, Taiwan.
Ying-Shu
YS
Liao
Centers for Disease Control, Taichung, Taiwan.
Chun-Hsing
CH
Liao
Centers for Disease Control, Taichung, Taiwan.
Chi-Sen
CS
Tsao
Centers for Disease Control, Taichung, Taiwan.
Chien-Shun
CS
Chiou
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D008826:Microbial Sensitivity Tests; D012475:Salmonella / Q000187:drug effects*; D013552:Swine; D013624:Taiwan
D000890:Anti-Infective Agents