[Application of synthetic biology to sustainable utilization of Chinese materia medica resources].
Bioactive natural products are the material bases of Chinese materia medica resources. With successful applications of synthetic biology strategies to the researches and productions of taxol, artemisinin and tanshinone, etc, the potential ability of synthetic biology in the sustainable utilization of Chinese materia medica resources has been attracted by many researchers. This paper reviews the development of synthetic biology, the opportunities of sustainable utilization of Chinese materia medica resources, and the progress of synthetic biology applied to the researches of bioactive natural products. Furthermore, this paper also analyzes how to apply synthetic biology to sustainable utilization of Chinese materia medica resources and what the crucial factors are. Production of bioactive natural products with synthetic biology strategies will become a significant approach for the sustainable utilization of Chinese materia medica resources.
Lu-Qi
LQ
Huang
Wei
W
Gao
Yong-Jin
YJ
Zhou
D045784:Abietanes / Q000235:genetics / Q000378:metabolism; D037621:Artemisinins / Q000378:metabolism; D053898:Biosynthetic Pathways; D001709:Biotechnology; D004365:Drugs, Chinese Herbal / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism; D036145:Ginsenosides / Q000235:genetics / Q000378:metabolism; D060847:Metabolic Engineering / Q000379:methods*; D017239:Paclitaxel / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D027561:Salvia miltiorrhiza / Q000235:genetics* / Q000378:metabolism*; D058615:Synthetic Biology
D045784:Abietanes; D037621:Artemisinins; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; C021751:tanshinone; C031327:artemisinin; D017239:Paclitaxel