Genetic variations of MMP9 gene and intracerebral hemorrhage susceptibility: a case-control study in Chinese Han population.
OBJECTIVE
To investigate the association between genetic variations of matrix metalloproteinase 9 (MMP9) gene and intracerebral hemorrhage (ICH) susceptibility in Chinese Han population.


METHODS
The clinical data and peripheral blood samples from the patients with ICH and hypertension, and controlled subjects with hypertension only, were collected. MassARRAY Analyzer was used to genotype the tagger single nucleotide polymorphism (SNP) of MMP9 gene. Haploview4.2 and Unphased3.1.7 were employed to construct haplotypes and to analyze the association between genetic variations (alleles, genotypes and haplotypes) of MMP9 gene and ICH susceptibility.


RESULTS
181 patients with ICH and hypertension, and 197 patients with hypertension only, were recruited between Sep 2009 and Oct 2010. Patients in the ICH group were younger (61.80 ± 13.27 vs. 72.44 ± 12.71 years, p<0.05). Other conventional risk factors between the ICH and control groups were similar. There were 6 Tagger SNPs and 4 haplotypes of MMP9 gene in our sample population. Our logistical regression analysis showed that there were no significant associations between genetic variations of the MPP9 gene and ICH susceptibility (all p>0.05).


CONCLUSIONS
The genetic variations of MMP9 gene were not significantly associated with ICH susceptibility in the Chinese Han population.
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China; Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Jie
J
Yang
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.
Bo
B
Wu
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sen
S
Lin
Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Junshan
J
Zhou
Department of Neurosurgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China.
Yingbin
Y
Li
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.
Wei
W
Dong
The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, NSW 2050, Australia.
Hisatomi
H
Arima
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.
Chanfei
C
Zhang
Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Yukai
Y
Liu
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: wyplmh@hotmail.com.
Ming
M
Liu
D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000150:complications / Q000235:genetics*; D019295:Computational Biology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications; D016015:Logistic Models; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018709:Statistics, Nonparametric
D020780:Matrix Metalloproteinase 9
Etiology; Genotype; Haplotype; Intracerebral hemorrhage; Matrix metalloproteinase 9; Single nucleotide polymorphism