Can Mean Platelet Volume and Platelet Distrubition Width be Possible Markers for Ectopic Pregnancy and Tubal Rupture? (MPV and PDW in Ectopic Pregnancy).
OBJECTIVE
We aimed to evaluate the alterations in serum levels of platelet indices such as mean platelet volume (MPV) and platelet distribution width (PDW) in ectopic pregnancy (EP) and discuss the mechanism of the alterations in MPV and PDW.


METHODS
This retrospective evaluation of 153 tubal EP patients (39 ruptured and 114 non-ruptured) admitted to our clinic between 2009 and 2013 and 67 healthy pregnancies was conducted. The data regarding the maternal age, hemoglobin level, platelet level, MPV, PDW was analyzed.


RESULTS
MPV was lower in the EP, especially in ruptured EP, compared to control group. However, no significant difference could be found between the groups (p=0.616). PDW was higher in the EP, especially in ruptured EP, compared to control group, however there was no statistical difference between the three groups (p=0.451). Platelet counts were significantly lower in ruptured EP compared to non-ruptured ectopic pregnancies and control groups (p=0.005).


CONCLUSIONS
MPV seems to be lower in ruptured EP suggesting the possible high grade inflammation in pathology. Platelet counts tend to be lower in ruptured EP suggesting the consumption of the platelets at the inflammation site. However, further studies are needed to describe the usefulness of the platelet indices in the diagnosis and clinical follow-up of EP. Our preliminary results show that MPV levels may decrease in the ruptured EP cases. At the same time, PDW levels may increase.
Burcu Artunc Ulkumen, Celal Bayar University School of Medicine, Obstetrics and Gynecology Department, Manisa, Turkey.
Burcu
B
Artunc Ulkumen
Halil Gursoy Pala, Celal Bayar University School of Medicine, Obstetrics and Gynecology Department, Manisa, Turkey.
Halil Gursoy
HG
Pala
Esat Calik, Celal Bayar University School of Medicine, Obstetrics and Gynecology Department, Manisa, Turkey.
Esat
E
Calik
Semra Oruc Koltan, Celal Bayar University School of Medicine, Obstetrics and Gynecology Department, Manisa, Turkey.
Semra
S
Oruc Koltan
Ectopic pregnancy; Mean platelet value; Platelet distribution width; Platelet count