Relation of INHBA gene expression to outcomes in gastric cancer after curative surgery.
Inhibin-βA (INHBA), a ligand belonging to the transforming growth factor-β superfamily, is associated with cell proliferation in cancer. We studied the relations of INHBA gene expression to clinicopathological factors and outcomes in 168 patients with gastric cancer who underwent curative surgery. Relative INHBA gene expression was measured in surgical specimens of cancer tissue and adjacent normal mucosa by quantitative real-time, reverse-transcription polymerase chain reaction. INHBA expression levels were significantly higher in cancer tissue than in adjacent normal mucosa and were related to TNM stage and venous invasion. High INHBA gene expression was associated with significantly poorer 5-year overall survival than was low expression. On multivariate analysis, INHBA gene expression was an independent prognostic factor. Overexpression of the INHBA gene is considered a useful independent predictor of outcomes in patients with gastric cancer after curative surgery.
Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafunecho, Minami-ku, Yokohama, Kanagawa 232-0024, Japan. ohshimatakashi@yahoo.co.jp.
Takashi
T
Oshima
Kazue
K
Yoshihara
Toru
T
Aoyama
Shinich
S
Hasegawa
Tsutomu
T
Sato
Naoto
N
Yamamoto
Nozaki
N
Akito
Manabu
M
Shiozawa
Takaki
T
Yoshikawa
Kazushi
K
Numata
Yasushi
Y
Rino
Chikara
C
Kunisaki
Katsuaki
K
Tanaka
Makoto
M
Akaike
Toshio
T
Imada
Munetaka
M
Masuda
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D005260:Female; D005743:Gastrectomy / Q000401:mortality; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D028322:Inhibin-beta Subunits / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D059467:Transcriptome
D014408:Biomarkers, Tumor; C103008:inhibin beta A subunit; D028322:Inhibin-beta Subunits
Inhibin beta A; gastric cancer; prognostic factor