Simultaneous hepatosplenic T-cell lymphoma and myelofibrosis.
Hepatosplenic T-cell lymphoma (HSTL) is a rare T-cell neoplasm of the lymphoid system. This type of lymphoma is characterized by sinusoidal infiltration of spleen, liver, bone marrow and lymph nodes by neoplastic lymphocytes. Here, we discuss a patient who had a left axillary lymph node biopsy with characteristic histological and immunohistochemical features of HSTL. In addition, infiltrating neoplastic T-cells and simultaneous characteristic features of myelofibrosis (MF) were also present in the bone marrow biopsy specimen. In contrast to secondary MF, primary MF is a progressive disease and may significantly affect the prognosis of coexisting HSTL. There are few reports in the literature talking about mild bone marrow fibrosis in association with T cell lymphoma, however marked increase in bone marrow fibrosis and HSTL never being reported. This case is shedding light on HSTL and marked increase in bone marrow fibrosis.
Department of Pathology, Wayne State University, Detroit, MI 48201, USA.
Ali M
AM
Gabali
Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA.
Tarek
T
Jazaerly
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, The Methodist Hospital Research Institute, Houston, TX, USA.
Chung-Che Jeff
CC
Chang
Department of Pathology, Case Western Reserve University, Metro Health Medical Center, Cleveland, Ohio, USA.
Ronald
R
Cleveland
Department of Pathology, Case Western Reserve University, Metro Health Medical Center, Cleveland, Ohio, USA.
Lawrence
L
Kass
Bone marrow; CD3; Jak2; T-cell; liver