Efficacy of amitraz plus inactivated parapoxvirus ovis in the treatment of canine generalised demodicosis.
Canine generalised demodicosis (CGD) is a challenging disease to treat effectively. Inactivated parapoxvirus ovis (iPPVO) could help to accelerate treatment with acaricidial therapy by altering the immune response. This study was designed to investigate the effects of treating CGD with amitraz plus iPPVO in terms of clinical outcomes and blood parameters. The study involved 16 dogs ranging in age from eight months to six years and weighing between 10 and 40 kg. Eight dogs were treated with amitraz and eight with amitraz plus iPPVO. Biochemical analysis of whole blood and serum, including serum C reactive protein (CRP) and serum amyloid A (SAA), was performed. Skin scrapings were conducted on days 0, 10, 40, 80 and 120 of treatment, and mite numbers were recorded. Clinical remission was determined according to mite numbers and clinical scores. The difference in mean whole remission days between the amitraz group (104.3 days) and the amitraz+iPPVO group (84.5 days) was statistically significant (P<0.05). Mean clinical scores were also significantly better in the amitraz+iPPVO (5.60) group when compared with the amitraz group (7.65). No adverse reactions were observed in either group. In view of these findings, the use of iPPVO in conjunction with amitraz can be recommended for treating CGD.
Department of Internal Medicine, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun 55139, Turkey.
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Pekmezci
Department of Preclinical Science, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun 55139, Turkey.
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Pekmezci
Department of Internal Medicine, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun 55139, Turkey.
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Guzel
Department of Biochemistry, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun 55139, Turkey.
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Cenesiz
Department of Parasitology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun 55139, Turkey.
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Gurler
Department of Internal Medicine, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun 55139, Turkey.
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Gokalp
D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000662:veterinary; D004283:Dog Diseases / Q000276:immunology / Q000628:therapy*; D004285:Dogs; D005260:Female; D008297:Male; D008924:Mite Infestations / Q000276:immunology / Q000628:therapy / Q000662:veterinary*; D018157:Parapoxvirus / Q000502:physiology*; D014052:Toluidines / Q000627:therapeutic use*; D016896:Treatment Outcome; D038301:Virus Inactivation
D000977:Antiparasitic Agents; D014052:Toluidines; C014983:amitraz
Clinical practice; Dermatology; Dogs; Drug administration; Immunology; Parasitology