Human germ cell differentiation from pluripotent embryonic stem cells and induced pluripotent stem cells.
Although 10-15 % of couples are infertile, little is known of the diverse, underlying pathologies in men and women with poor germ cell production; furthermore, for those with few or no high-quality germ cells, there are few options available for treatment. Thus, over the last decade, concerted efforts have been aimed at developing a biological system to probe the fundamentals of human egg and sperm production via pluripotent stem cell cells with the hopes of informing clinical decisions and ultimately providing alternative methods for therapy which may include developing a source of germ cells ultimately for reproductive purposes.
CIPF & Fundación Instituto Valenciano de Infertilidad (FIVI), Valencia University, INCLIVA, Valencia, 46015, Spain.
Jose V
JV
Medrano
Carlos
C
Simon
Renee Reijo
RR
Pera
D002454:Cell Differentiation / Q000235:genetics*; D053595:Embryonic Stem Cells / Q000166:cytology*; D005260:Female; D005854:Germ Cells / Q000166:cytology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D008297:Male; D008967:Molecular Biology / Q000379:methods; D010063:Ovum / Q000166:cytology; D013094:Spermatozoa / Q000166:cytology