Interpreting the conductance blockades of DNA translocations through solid-state nanopores.
Solid-state nanopore electrical signatures can be convoluted and are thus challenging to interpret. In order to better understand the origin of these conductance changes, we investigate the translocation of DNA through small, thin pores over a range of voltage. We observe multiple, discrete populations of conductance blockades that vary with applied voltage. To describe our observations, we develop a simple model that is applicable to solid-state nanopores generally. These results represent an important step toward understanding the dynamics of the electrokinetic translocation process.
Department of Biomedical Engineering and ‡Comprehensive Cancer Center, Wake Forest University School of Medicine , Winston-Salem, North Carolina 27101, United States.
Autumn T
AT
Carlsen
Osama K
OK
Zahid
Jan
J
Ruzicka
Ethan W
EW
Taylor
Adam R
AR
Hall
D004247:DNA / Q000737:chemistry*; D004553:Electric Conductivity; D004563:Electrochemistry / Q000379:methods*; D007477:Ions; D007700:Kinetics; D008422:Materials Testing; D015233:Models, Statistical; D058608:Nanopores; D036103:Nanotechnology / Q000379:methods*; D012825:Silicon / Q000737:chemistry; D013816:Thermodynamics
D007477:Ions; D004247:DNA; D012825:Silicon