Aplysinellamides A-C, bromotyrosine-derived metabolites from an Australian Aplysinella sp. marine sponge.
Mass-directed fractionation of an extract from the Australian marine sponge Aplysinella sp., from the Great Barrier Reef, resulted in the isolation of four new bromotyrosine derivatives, aplysinellamides A-C (1-3) and aplysamine-1-N-oxide (4), along with six known compounds (5-10). The structure elucidation of compounds 1-4 was based on their 1D and 2D NMR and MS spectroscopic data. Aplysamine-1 (6) increased the apolipoprotein E secretion from human CCF-STTG1 astrocytoma cells by 2-fold at the concentration of 30 μM.
Eskitis Institute, Griffith University , Brisbane, QLD 4111, Australia.
Li-Wen
LW
Tian
Yunjiang
Y
Feng
Yoko
Y
Shimizu
Tom
T
Pfeifer
Cheryl
C
Wellington
John N A
JN
Hooper
Ronald J
RJ
Quinn
D000818:Animals; D001053:Apolipoproteins / Q000187:drug effects / Q000378:metabolism; D001254:Astrocytoma / Q000378:metabolism; D001315:Australia; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
D001053:Apolipoproteins; C509742:aplysamine-1; C000591964:aplysinellamide A; C000591965:aplysinellamide B; C000591966:aplysinellamide C; C475724:bromotyrosine; D014443:Tyrosine