CREB is activated in smooth muscle cells isolated from atherosclerotic plaques and reduces smooth muscle cell proliferation via p21-dependent mechanism.
National Center for Pharmaceutical Screening, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China; State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing 100050, China.
Lan
L
Sun
National Center for Pharmaceutical Screening, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China; Beijing Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, China.
Rui
R
Zhao
Department of Geriatric Cardiology, Chinese PLA General Hospital, No. 28, Fuxing Road, Beijing 100853, China.
Yongyi
Y
Bai
Department of Geriatric Cardiology, Chinese PLA General Hospital, No. 28, Fuxing Road, Beijing 100853, China.
Ruihua
R
Cao
Department of Neurosurgery, PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
Fuyu
F
Wang
National Center for Pharmaceutical Screening, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China; State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing 100050, China.
Shengqian
S
Yang
National Center for Pharmaceutical Screening, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China; State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing 100050, China.
Zhizhen
Z
Qin
National Center for Pharmaceutical Screening, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China; Beijing Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, China. Electronic address: dugh@imm.ac.cn.
Guanhua
G
Du
D000368:Aged; D049109:Cell Proliferation / Q000502:physiology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000096:biosynthesis*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle / Q000378:metabolism* / Q000473:pathology; D058226:Plaque, Atherosclerotic / Q000378:metabolism* / Q000473:pathology
C493956:CDKN1A protein, human; C115163:CREB1 protein, human; D017362:Cyclic AMP Response Element-Binding Protein; D050759:Cyclin-Dependent Kinase Inhibitor p21
Atherosclerotic plaques; Carotid endarterectomy; Human aortic smooth muscle cells (hASMCs); cAMP response element-binding protein (CREB); p21/Cip1