TEG® functional fibrinogen analysis may overestimate fibrinogen levels.
Fibrinogen is of crucial importance in patients with ongoing bleeding. In this study, we compared fibrinogen concentration measured by thrombelastography (TEG®) with fibrinogen plasma concentration determined by Clauss. Sixty-three surgical patients and 38 healthy controls were included. For the whole group (patients and controls, n = 101), TEG® functional fibrinogen was on average 1.0 g/L higher than the plasma fibrinogen concentration (3.5 vs 2.5 g/L, 95% confidence interval for difference 0.8 to 1.2 g/L, P < 0.0001). Similar patterns were observed when patients and healthy controls were analysed separately. The fibrinogen level may be overestimated when assessed using TEG® compared with the fibrinogen plasma concentration measured by the conventional method.
From the *Department of Medicine, Division of Hematology, Coagulation Unit, Karolinska University Hospital, Stockholm, Sweden; †Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden; ‡Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; §Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; ‖Department of Anesthesiology and Intensive Care, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden; and ¶Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Anna
A
Agren
Agneta Taune
AT
Wikman
Anders
A
Ostlund
Gustaf
G
Edgren
D000328:Adult; D000368:Aged; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D013916:Thrombelastography / Q000379:methods*
D005340:Fibrinogen