Quiescent melanocytes form primary cilia.
We show, for the first time, that melanocytes can form a primary cilium in vitro, corresponding to an immotile or sensory cilium. Such cilia are observed when melanocytes reach confluence or when medium nutrient levels are insufficient. This observation should greatly improve our understanding of the signal transduction processes potentially occurring in these cells during embryonic development, homeostasis in adulthood and melanomagenesis.
Normal and Pathological Development of Melanocytes, Centre de Recherche, Institut Curie, Orsay, France; CNRS UMR3347, Orsay, France; INSERM U1021, Orsay, France; Ligue Nationale contre le Cancer, Equipe labellisée, Orsay, France.
Madeleine
M
Le Coz
Alexandre
A
Benmerah
Lionel
L
Larue
D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000502:physiology; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000502:physiology*; D002923:Cilia / Q000473:pathology* / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D008544:Melanocytes / Q000473:pathology* / Q000502:physiology; D051379:Mice; D015398:Signal Transduction / Q000502:physiology
acetylated tubulin; pericentrin; proliferation