Mucinous tumors of the ovary: current thoughts on diagnosis and management.
Mucinous tumors of the ovary represent a spectrum of neoplastic disorders, including benign mucinous cystadenoma, pseudomyxoma peritonei, mucinous tumors of low malignant potential (borderline), and invasive mucinous ovarian carcinoma. These tumors are related closely to each other and are distinct from other histologic subtypes of epithelial ovarian neoplasms from a clinical, histologic, and molecular standpoint. A continuum appears to be present from benign to borderline to malignant, which is different from other types of epithelial ovarian cancer. Mutational profiles are also distinct, as KRAS mutations are common, but p53 and BRCA mutations are infrequent. These characteristics lead to specific biologic behavior and guide both clinical management and research efforts in patients with mucinous ovarian tumors.
Department of Gynecologic Oncology and Reproductive Sciences, The University of Texas M.D. Anderson Cancer Center, 1155 Herman Pressler Blvd, Unit 1362, P.O. Box 301439, Houston, TX, 77030-1439, USA, jbbrown@mdanderson.org.
Jubilee
J
Brown
Michael
M
Frumovitz
D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D018291:Cystadenoma, Mucinous / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D019468:Disease Management; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor