[Treatment of scabies and Ascabiol(®) supply disruption: what about the pediatric population?].
Scabies is a disease in steady increase in Île-de-France region. Standard treatment, Ascabiol(®) (benzyl benzoate/sulfiram), is back-order for several months and its return remains uncertain. Facing this drug shortage, French Drug Agency (ANSM) has imported a drug from Germany, Antiscabiosum 10 % (benzyl benzoate), to treat patients having contraindications for other scabicides available in France (ivermectin, esdepallethrine). However, infants less than 1 year (<15 kg) and asthmatics infants have no alternative treatment. A multidisciplinary workgroup explored the various existing therapeutic alternatives in France and worldwide. From ANSM's recommendations and group's experience, a decision algorithm was proposed for treating patients. However, pediatric context implied the use of off-label drugs. Proposed treatments widely known by practitioners, prescriptions-types, dose, modalities of use and dispensation, and flyers to patients were realized to optimize treatment efficacy.
Service de pharmacie, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.
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Berthe-Aucejo
Service de pharmacie, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France. Electronic address: sonia.prot-labarthe@rdb.aphp.fr.
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Prot-Labarthe
Service d'urgences pédiatriques, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.
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Pull
Service de pédiatrie générale, faculté de médecine Denis-Diderot (Paris VII), hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.
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Lorrot
Service de pharmacie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux 75010 Paris, France.
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Touratier
Service de pharmacie, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France.
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Trout
Service de pharmacie, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France; Faculté de pharmacie, université Paris Descartes (Paris V), 1, avenue Claude-Vellefaux, 75010 Paris, France; Laboratoire éducation et pratiques de santé, université Paris XIII, Bobigny, France.
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Bourdon
Service de dermatologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France.
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Dehen
Service de pédiatrie générale, faculté de médecine Denis-Diderot (Paris VII), hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France; Service de dermatologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France.
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Bourrat
D001565:Benzoates / Q000600:supply & distribution* / Q000627:therapeutic use; D002648:Child; D004203:Disinfection; D005602:France; D006077:Government Agencies; D006801:Humans; D007306:Insecticides / Q000600:supply & distribution* / Q000627:therapeutic use*; D007559:Ivermectin / Q000627:therapeutic use; D026023:Permethrin / Q000627:therapeutic use; D012532:Scabies / Q000188:drug therapy*
D001565:Benzoates; D007306:Insecticides; D026023:Permethrin; D007559:Ivermectin; C006723:benzyl benzoate