[Cycloferon as an agent for the anti-relapse therapy in patients with chronic hyperplastic sinusitis].
The data on the efficacy of cycloferon as an agents of antirelapsing therapy in management of 123 patients with chronic hyperplastic sinusitis are presented. The drug induction of endogenous interferons was validated by the properties of the local mucosal immunity, virus invasion and virus persistence in the nasal an d accessory nasal sinuses mucosa, as well as by different levels ofthe interferon production deficiency. The clinical efficacy was stated in 53% of the cases. The relapses were recorded in 13.1% of the patients treated with cycloferon vs. 33.3% of the patients under the local corticosteroid therapy.
I P
IP
Vasilenko
M G
MG
Romantsov
A I
AI
Kriukov
S S
SS
Grigorian
A L
AL
Kovalenko
D000166:Acridines / Q000627:therapeutic use*; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects*; D007369:Interferon Inducers / Q000627:therapeutic use*; D016898:Interferon-alpha / Q000096:biosynthesis / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D009298:Nasal Polyps / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D012129:Respiratory Function Tests; D055502:Secondary Prevention; D012852:Sinusitis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
D000166:Acridines; D000305:Adrenal Cortex Hormones; D007369:Interferon Inducers; D016898:Interferon-alpha; D007371:Interferon-gamma; C026430:10-carboxymethyl-9-acridanone