PTRcombiner: mining combinatorial regulation of gene expression from post-transcriptional interaction maps.
BACKGROUND
The progress in mapping RNA-protein and RNA-RNA interactions at the transcriptome-wide level paves the way to decipher possible combinatorial patterns embedded in post-transcriptional regulation of gene expression.


RESULTS
Here we propose an innovative computational tool to extract clusters of mRNA trans-acting co-regulators (RNA binding proteins and non-coding RNAs) from pairwise interaction annotations. In addition the tool allows to analyze the binding site similarity of co-regulators belonging to the same cluster, given their positional binding information. The tool has been tested on experimental collections of human and yeast interactions, identifying modules that coordinate functionally related messages.


CONCLUSIONS
This tool is an original attempt to uncover combinatorial patterns using all the post-transcriptional interaction data available so far. PTRcombiner is available at http://disi.unitn.it/~passerini/software/PTRcombiner/.
Gianluca
G
Corrado
Toma
T
Tebaldi
Giulio
G
Bertamini
Fabrizio
F
Costa
Alessandro
A
Quattrone
Department of Information Engineering and Computer Science (DISI), University of Trento, 38123 Trento, Italy. gabriella.viero@cnr.it.
Gabriella
G
Viero
Andrea
A
Passerini
D001665:Binding Sites; D005786:Gene Expression Regulation; D012323:RNA Processing, Post-Transcriptional