Performance of the OraQuick HCV rapid antibody test for screening exposed patients in a hepatitis C outbreak investigation.
During a nosocomial hepatitis C outbreak, emergency public clinics employed the OraQuick HCV rapid antibody test on site, and all results were verified by a standard enzyme immunoassay (EIA). Of 1,157 persons, 1,149 (99.3%) exhibited concordant results between the two tests (16 positive, 1,133 negative). The sensitivity, specificity, positive predictive value, and negative predictive value were 94.1%, 99.5%, 72.7%, and 99.9%, respectively. OraQuick performed well as a screening test during an outbreak investigation and could be integrated into future hepatitis C virus (HCV) outbreak testing algorithms.
Public Health Laboratories, Division of Public Health Services, New Hampshire Department of Health and Human Services, Concord, New Hampshire, USA.
Fengxiang
F
Gao
Division of Public Health Services, New Hampshire Department of Health and Human Services, Concord, New Hampshire, USA Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Elizabeth A
EA
Talbot
Public Health Laboratories, Division of Public Health Services, New Hampshire Department of Health and Human Services, Concord, New Hampshire, USA.
Carol H
CH
Loring
Public Health Laboratories, Division of Public Health Services, New Hampshire Department of Health and Human Services, Concord, New Hampshire, USA.
Jill J
JJ
Power
Division of Public Health Services, New Hampshire Department of Health and Human Services, Concord, New Hampshire, USA Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Jodie
J
Dionne-Odom
Division of Public Health Services, New Hampshire Department of Health and Human Services, Concord, New Hampshire, USA.
Sharon
S
Alroy-Preis
Division of Public Health Services, New Hampshire Department of Health and Human Services, Concord, New Hampshire, USA.
Patricia
P
Jackson
Public Health Laboratories, Division of Public Health Services, New Hampshire Department of Health and Human Services, Concord, New Hampshire, USA clbean@dhhs.state.nh.us.
Christine L
CL
Bean
D019411:Clinical Laboratory Techniques / Q000379:methods*; D003428:Cross Infection / Q000175:diagnosis / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D006526:Hepatitis C / Q000175:diagnosis* / Q000453:epidemiology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity
D018937:Hepatitis C Antibodies