Case report of successful treatment of fibrosing cholestatic hepatitis C with sofosbuvir and ribavirin after liver transplantation.
Fibrosing cholestatic hepatitis is an unusual complication of hepatitis C virus (HCV) recurrence after liver transplant. Fibrosing cholestatic hepatitis is marked by aggressive progression of cholestasis and fibrosis, leading to accelerated graft loss and/or death. Sofosbuvir (GS-7977) is an oral nucleotide analogue inhibitor of HCV polymerase activity. It is a second-generation, direct-acting, antiviral for the treatment of HCV infection. This case illustrates a patient with recurrent HCV with fibrosing cholestatic hepatitis, who was successfully treated with a combination of sofosbuvir and ribavirin with normalization of liver enzyme activities and resolution of HCV-related symptoms. The favorable side effect profile and the lack of drug-drug interaction with immunosuppressive medications make the combination of sofosbuvir and ribavirin a promising regimen for severe HCV recurrence.
The Recanati/Miller Transplantation Institute, Mount Sinai Health System, New York, New York.
Brian
B
Kim
The Lillian and Henry M. Stratton - Hans Popper Department of Pathology, Mount Sinai Health System, New York, New York.
Anshu
A
Trivedi
The Lillian and Henry M. Stratton - Hans Popper Department of Pathology, Mount Sinai Health System, New York, New York.
Swan N
SN
Thung
The Recanati/Miller Transplantation Institute, Mount Sinai Health System, New York, New York.
Priya
P
Grewal
D000998:Antiviral Agents / Q000627:therapeutic use*; D001706:Biopsy; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D004359:Drug Therapy, Combination; D019698:Hepatitis C, Chronic / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000601:surgery* / Q000821:virology; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012254:Ribavirin / Q000627:therapeutic use*; D000069474:Sofosbuvir; D016896:Treatment Outcome; D014542:Uridine Monophosphate / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000998:Antiviral Agents; D012254:Ribavirin; D014542:Uridine Monophosphate; D000069474:Sofosbuvir