Cytotoxic dimeric quinolone-terpene alkaloids from the root bark of Zanthoxylum rhetsa.
Four quinolone-terpene alkaloids, chelerybulgarine (1), 2'-episimulanoquinoline (3), 2,11-didemethoxyvepridimerine B (4), and rhetsidimerine (5) were isolated from the root bark of Zanthoxylum rhetsa DC. Chelerybulgarine (1) is a C-C linked terpene alkaloid where the C-6 of dihydrochelerythrine is linked to C-11 of the sesquiterpenoid 10β-methoxybulgarene. 2'-Episimulanoquinoline is a dimeric alkaloid containing dihydrochelerythrine and 8-methoxy-N-methylflindersine moieties, whereas 2,11-didemethoxyvepridimerine B and rhetsidimerine are dimeric prenylated quinolone alkaloids. Seven of the isolated compounds exhibited weak cytotoxicity when tested against a panel of six human stomach-cancer cell lines.
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh.
Monira
M
Ahsan
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh.
Mohammad Rashedul
MR
Haque
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh.
Md Belayet
MB
Hossain
Institute of Nutrition and Food Science, University of Dhaka, Dhaka 1000, Bangladesh.
Sheikh Nazrul
SN
Islam
Department of Pharmaceutical Sciences, University of Strathclyde, SIBS Building, 27 Taylor Street, Glasgow G4 ONR, UK.
Alexander I
AI
Gray
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh. Electronic address: cmhasan@gmail.com.
Choudhury Mahmood
CM
Hasan
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D032106:Zanthoxylum / Q000737:chemistry*
D000470:Alkaloids; D010936:Plant Extracts
2,11-Didemethoxyvepridimerine; 2′-Episimulanoquinoline; Chelerybulgarine; Dihydrochelerythrine; Rhetsidimerine