Functions of volume-sensitive and calcium-activated chloride channels.
The review describes molecular and functional properties of the volume regulated anion channel and Ca(2+)-dependent Cl(-) channels belonging to the anoctamin family with emphasis on physiological importance of these channels in regulation of cell volume, cell migration, cell proliferation, and programmed cell death. Finally, we discuss the role of Cl(-) channels in various diseases.
Department of Biology, University of Copenhagen, 13 Universitetsparken, Copenhagen Ø, Denmark.
Else Kay
EK
Hoffmann
Niels Bjerre
NB
Holm
Ian Henry
IH
Lambert
D000818:Animals; D000838:Anions / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002468:Cell Physiological Phenomena; D018118:Chloride Channels / Q000378:metabolism*; D006801:Humans
D000838:Anions; D018118:Chloride Channels; D002118:Calcium
anoctamins; apoptosis; cell migration; proliferation; volume regulated anion channel