Repeated intravenous administrations of teneurin-C terminal associated peptide (TCAP)-1 attenuates reinstatement of cocaine seeking by corticotropin-releasing factor (CRF) in rats.
The teneurin c-terminal associated peptides (TCAP) have been implicated in the regulation of the stress response, possibly via a corticotropin-releasing factor (CRF)-related mechanism. We have previously shown that repeated intracerebroventricular (ICV) injections of TCAP-1 attenuate the reinstatement of cocaine seeking by CRF in rats. Here, we determined whether intravenous (IV) administrations of TCAP-1 would likewise attenuate CRF-induced reinstatement, and whether this effect would vary depending on the rat's history of cocaine self administration. Rats were trained to self-administer cocaine for 10 days, during once daily sessions that were either 3h ("short access"; ShA) or 6h ("long access"; LgA). Rats were then given five daily injections of TCAP-1 (0, 300, or 3,000 pmol, IV) in their home cage. Subsequently, they were returned to the self-administration chambers where extinction of cocaine seeking and testing for CRF-induced reinstatement of cocaine seeking was carried out. Repeated IV administrations of TCAP-1 were efficacious in attenuating CRF-induced reinstatement of cocaine seeking, but at different doses in ShA and LgA rats. Taken together, the findings extend previous work showing a consistent effect of repeated ICV TCAP-1 on CRF-induced reinstatement of cocaine seeking, and point to a potential therapeutic benefit of TCAP-1 in attenuating cocaine seeking behaviors.
Department of Psychology, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, Canada; Department of Cell and Systems Biology, University of Toronto, 1265 Military Trail, Toronto, ON M1C 1A4, Canada. Electronic address: erb@utsc.utoronto.ca.
Suzanne
S
Erb
Department of Psychology, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, Canada.
Matthew
M
McPhee
Department of Psychology, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, Canada.
Zenya J
ZJ
Brown
Department of Psychology, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, Canada.
David A
DA
Kupferschmidt
Department of Cell and Systems Biology, University of Toronto, 1265 Military Trail, Toronto, ON M1C 1A4, Canada.
Lifang
L
Song
Department of Cell and Systems Biology, University of Toronto, 1265 Military Trail, Toronto, ON M1C 1A4, Canada.
David A
DA
Lovejoy
D061605:Administration, Intravenous; D000818:Animals; D002491:Central Nervous System Agents / Q000627:therapeutic use*; D003042:Cocaine / Q000008:administration & dosage; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000503:physiopathology; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D058999:Drug-Seeking Behavior / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects; D008297:Male; D010455:Peptides / Q000008:administration & dosage* / Q000627:therapeutic use; D020318:Rats, Long-Evans; D012646:Self Administration
D002491:Central Nervous System Agents; D018765:Dopamine Uptake Inhibitors; D010455:Peptides; C000594509:teneurin-C terminal associated peptide; D003346:Corticotropin-Releasing Hormone; D003042:Cocaine
CRF; Cocaine; Intravenous; Reinstatement; TCAP; Teneurin