Association and predictive value analysis for resting heart rate and diabetes mellitus on cardiovascular autonomic neuropathy in general population.
BACKGROUND
The purpose of this study was to evaluate the predictive value of DM and resting HR on CAN in a large sample derived from a Chinese population.


METHODS
We conducted a large-scale, population-based, cross-sectional study to explore the relationships of CAN with DM and resting HR. A total of 387 subjects were diagnosed with CAN in our dataset. The associations of CAN with DM and resting HR were assessed by a multivariate logistic regression (MLR) analysis (using subjects without CAN as a reference group) after controlling for potential confounding factors. The area under the receiver-operating characteristic curve (AUC) was used to evaluate the predictive performance of resting HR and DM.


RESULTS
A tendency toward increased CAN prevalence with increasing resting HR was reported (P for trend <0.001). MLR analysis showed that DM and resting HR were very significantly and independently associated with CAN (P < 0.001 for both). Resting HR alone or combined with DM (DM-HR) both strongly predicted CAN (AUC = 0.719, 95% CI 0.690-0.748 for resting HR and AUC = 0.738, 95% CI 0.710-0.766 for DM-HR).


CONCLUSIONS
Our findings signify that resting HR and DM-HR have a high value in predicting CAN in the general population.
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No. 12 Wulumuqi Mid Road, Building No. 0, Jing'an District, Shanghai 200040, China.
Zi-Hui
ZH
Tang
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No. 12 Wulumuqi Mid Road, Building No. 0, Jing'an District, Shanghai 200040, China.
Fangfang
F
Zeng
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No. 12 Wulumuqi Mid Road, Building No. 0, Jing'an District, Shanghai 200040, China.
Zhongtao
Z
Li
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No. 12 Wulumuqi Mid Road, Building No. 0, Jing'an District, Shanghai 200040, China.
Linuo
L
Zhou
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D002681:China / Q000453:epidemiology; D003327:Coronary Disease / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D058065:Diabetic Cardiomyopathies / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D042241:Early Diagnosis; D005260:Female; D006306:Health Surveys; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence