Impairment of renal structure and function following heterogeneous chemical mixture exposure in rats.
Renal structural and functional alterations following an exposure to a heterogeneous chemical mixture (HCM) of phthalic acid di butyl ester, 1, 2-dichlorobenzene, cadmium chloride and chromium trioxide, administered through oral gavage in low doses (1/100 and 1/1000 of LD50 value of individual chemical) for 60 days, followed by withdrawal till 120 days resulted in significant rise in kidney lipid peroxidation and fall in the activities of enzymatic antioxidants. However, withdrawal of HCM treatment restored most of these altered parameters. Degenerative changes in the kidney included proximal convoluted tubules devoid of brush boarder with cytoplasmic blebbing, dissolution and sloughing of nuclei. Cortical glomeruli were also affected with epithelial disintegration, pyknosis of podocyte nuclei and mesengial cell hyperplasia. The morphological alterations recovered fully in the low dose compared to the high dose treatment group.
Kiran
K
Morya
Kauresh D
KD
Vachhrajani
D000818:Animals; D019256:Cadmium Chloride / Q000633:toxicity; D002722:Chlorobenzenes / Q000633:toxicity; D017608:Chromium Compounds / Q000633:toxicity; D045424:Complex Mixtures / Q000633:toxicity*; D004781:Environmental Exposure; D007668:Kidney / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D008297:Male; D010795:Phthalic Acids / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
D002722:Chlorobenzenes; D017608:Chromium Compounds; D045424:Complex Mixtures; D010795:Phthalic Acids; C032279:phthalic acid; C004726:2-dichlorobenzene; C028801:chromium trioxide; D019256:Cadmium Chloride