Cu(I)-mediated (18)F-trifluoromethylation of arenes: rapid synthesis of (18)F-labeled trifluoromethyl arenes.
This report is concerned with an efficient, Cu(I)-mediated method for the radiosynthesis of [(18)F]trifluoromethyl arenes, abundant motifs in small molecule drug candidates and potential radiotracers for positron emission tomography. Three (18)F-labelled radiotracer candidates were synthesised from [(18)F]fluoride ions as proof of principle. The new protocol is widely applicable for the synthesis of novel radiotracers in high radiochemical yields.
Kjemisk Institutt, Universitetet I Oslo, Sem Sælands vei 26, 0371, Oslo, Norway. Patrick.Riss@kjemi.uio.no.
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D002384:Catalysis; D003300:Copper / Q000737:chemistry; D005459:Fluorides / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000494:pharmacology
D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; C057829:copper fluoride; D003300:Copper; D005459:Fluorides