Three-dimensional computed tomographic volumetric changes in pancreas before and after living donor surgery for pancreas transplantation: effect of volume on glucose metabolism.
In the present study, we aimed to compare the pancreas volumetric changes before and after living donor surgery for pancreas transplantation, using three-dimensional (3D) computed tomography (CT) and glucose metabolism. Pancreatic volume (PV) measurement using 3D CT was performed in 13 consecutive donors who underwent distal pancreatectomy for simultaneous living donor pancreas and kidney transplantation. PV was measured using a workstation before and 3 months after living donor operation. As the parameters of glucose metabolism, hemoglobin A1c (HbA1c) level, fasting plasma glucose (FPG) level, body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), and insulinogenic index (IGI) were examined simultaneously with the PV measurement. The preoperative and postoperative PVs of pancreas was 30 ± 5 mL and 42 ± 9 mL, respectively. The postoperative PV was significantly higher than the preoperative PV (P < .01) and increased by approximately 40% at 3 months after surgery. The postoperative FPG and HbA1c levels were significantly higher than the preoperative values (P < .01). BMI decreased significantly after surgery (P < .01). No differences in HOMA-IR and IGI were noted between before and after surgery. Diabetes mellitus was not observed any of the 13 living donors during this period. Distal pancreatectomy for living donors caused an increase in the PV and maintained insulin resistance, but it was not sufficient to maintain glucose metabolism at the preoperative state.
Department of Surgery, Chiba-East National Hospital, Chiba, Japan. Electronic address: otsuki@cehpnet.com.
K
K
Otsuki
Department of Surgery, Chiba-East National Hospital, Chiba, Japan.
N
N
Akutsu
Department of Surgery, Chiba-East National Hospital, Chiba, Japan.
M
M
Maruyama
Department of Surgery, Chiba-East National Hospital, Chiba, Japan.
K
K
Saigo
Department of Surgery, Chiba-East National Hospital, Chiba, Japan.
M
M
Hasegawa
Department of Surgery, Chiba-East National Hospital, Chiba, Japan.
H
H
Aoyama
Department of Surgery, Chiba-East National Hospital, Chiba, Japan.
I
I
Matsumoto
Department of Surgery, Chiba-East National Hospital, Chiba, Japan.
T
T
Asano
Department of Surgery, Chiba-East National Hospital, Chiba, Japan.
T
T
Ito
Department of Surgery, Chiba-East National Hospital, Chiba, Japan.
T
T
Kenmochi
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D010179:Pancreas / Q000000981:diagnostic imaging*; D016035:Pancreas Transplantation; D014057:Tomography, X-Ray Computed / Q000379:methods*
D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human