[Efficacies and toxicities of different platinum-based combination chemotherapies for patients with advanced non-small cell lung cancer].
OBJECTIVE
To explore the efficacies and toxicities of different platinum-based combination chemotherapeutic regiments for patients with advanced non-small cell lung cancer (NSCLC).


METHODS
A total of 239 advanced NSCLC from January 2011 to December 2012 were reviewed in Xinqiao Hospital. The chemotherapeutic efficacies and adverse effects in the first-line treatment of advanced NSCLC by paclitaxel plus platinum (paclitaxel group, n = 113), gemcitabine plus platinum (gemcitabine group, n = 72) and docetaxel plus platinum (docetaxel group, n = 54) regiments were retrospectively analyzed and compared. Their efficacies and toxicities were analyzed by Chi-square test. And survival was estimated with Kaplan-Meier method.


RESULTS
The objective response rate (ORR) of three groups were 42.5%, 43.1% and 35.2% respectively (P = 0.612). The disease control rate (DCR) were 84.1%, 75.0% and 74.1% respectively (P = 0.198). The median progression-free survival was 5.6, 5.8 and 3.2 months respectively (P = 0.000). The major adverse effects were myelosuppression, gastrointestinal reaction, alopecia and neurotoxicity, etc. The incidence rate of neurotoxicity among three groups were 34.5% (39/113), 11.1% (8/72) and 18.5% (10/54) respectively (P = 0.001).No significant inter-group difference of adverse effects existed (all P > 0.05), except for neurotoxicity.


CONCLUSIONS
Three platinum-based combination chemotherapeutic regiments produce excellent efficacies with acceptable adverse effects. Their ORR and DCR were similar. And the median progression-free survival of paclitaxel and gemcitabine groups is significantly longer than that of docetaxel group.
Institute of Respiratory Diseases of PLA,Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Juan
J
Liu
Institute of Respiratory Diseases of PLA,Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Fuyun
F
Ji
Institute of Respiratory Diseases of PLA,Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Jin
J
Li
Institute of Respiratory Diseases of PLA,Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Bin
B
Wang
Institute of Respiratory Diseases of PLA,Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. Email: guoming_wu@sina.com.
Guoming
G
Wu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010984:Platinum / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
D010984:Platinum