Development of bacterial transglycosylase inhibitors as new antibiotics: moenomycin A treatment for drug-resistant Helicobacter pylori.
The problem of multidrug-resistant Helicobacter pylori requires new antibiotics development. We have evaluated a potential antibiotics, moenomycin A, which is classified as a phosphoglycolipid antibiotics that targets transglycosylase and is previously thought to be limited in Gram-positive bacteria. Herein, we report the activity of moenomycin A against multidrug-resistant H. pylori and the isolates from patients with different gastrointestinal diseases.
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan.
Yen-Yu
YY
Tseng
Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Jyh-Ming
JM
Liou
Genomics Research Center, Academia Sinica, Taipei 115, Taiwan.
Tsui-Ling
TL
Hsu
Genomics Research Center, Academia Sinica, Taipei 115, Taiwan.
Wei-Chieh
WC
Cheng
Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. Electronic address: mingshiang@ntu.edu.tw.
Ming-Shiang
MS
Wu
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan. Electronic address: chwong@gate.sinica.edu.tw.
Chi-Huey
CH
Wong
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001455:Bambermycins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D004381:Duodenal Ulcer / Q000382:microbiology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005756:Gastritis / Q000382:microbiology; D016695:Glycosyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D016481:Helicobacter Infections / Q000188:drug therapy / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D013274:Stomach Neoplasms / Q000382:microbiology*; D013276:Stomach Ulcer / Q000382:microbiology
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D001455:Bambermycins; C437243:moenomycin A; D016695:Glycosyltransferases
Antibiotics; Helicobacter pylori; Moenomycin; Transglycosylases