Aerobic exercise and not a diet supplemented with jussara açaí (Euterpe edulis Martius) alters hepatic oxidative and inflammatory biomarkers in ApoE-deficient mice.
The pulp of jussara açaí (Euterpe edulis Martius) fruit is rich in anthocyanins that exert antioxidant and anti-inflammatory effects similar to those exerted by aerobic exercise. In the present study, we investigated the effects of jussara açaí fruit pulp consumption, either alone or in combination with aerobic exercise, on the hepatic oxidative and inflammatory status of ApoE-deficient (ApoE - / - ) mice. Male mice were divided into four groups (control (C), control plus açaí, exercise plus açaí (EXA) and exercise (EX)) and fed the AIN-93M diet or the AIN-93M diet formulated to contain 2 % freeze-dried açaí pulp. Mice in the EX and EXA groups were subjected to a progressive running programme (5 d/week, 60 min/d, 16 m/min) for 12 weeks. Mice that were made to exercise exhibited reduced (40·85 %; P< 0·05) hepatic superoxide dismutase activity when compared with the C mice, independent of the açaí diet. Mice in the EX group exhibited a lower (42 %; P< 0·05) mRNA expression of monocyte chemotactic protein-1 in the liver compared with the C mice. Mice in the EXA and EX groups had lower percentages of hepatic lipid droplets (70 % and 56 %, respectively; P< 0·05) when compared with the C mice. Mice in the EX group had smaller (58 %; P< 0·05) area of lesions in the aorta when compared with the C mice. Serum lipid profile was not affected (P>0·05). In conclusion, aerobic exercise training rather than açaí fruit pulp consumption or a combination of both enhances the hepatic oxidative and inflammatory status of ApoE - / - mice.
Departamento de Educação Física,Universidade Federal de Viçosa (UFV), Avenida Peter Henry Rolfs, s/n,Viçosa,MG36570000,Brazil.
Cynthia Aparecida
CA
de Castro
Departamento de Educação Física,Universidade Federal de Viçosa (UFV), Avenida Peter Henry Rolfs, s/n,Viçosa,MG36570000,Brazil.
Antonio José
AJ
Natali
Departamento de Bioquímica e Biologia Molecular,Universidade Federal de Viçosa,Viçosa,MG,Brazil.
Luciana Marques
LM
Cardoso
Departamento de Parasitologia e Microbiologia,Universidade Federal de Juiz de Fora,Juiz de Fora,MG,Brazil.
Alessandra Barbosa
AB
Ferreira-Machado
Departamento de Nutrição e Saúde,Universidade Federal de Viçosa,Viçosa,MG,Brazil.
Alexandre Azevedo
AA
Novello
Departamento de Educação Física,Universidade Federal de Viçosa (UFV), Avenida Peter Henry Rolfs, s/n,Viçosa,MG36570000,Brazil.
Karina Ana
KA
da Silva
Departamento de Nutrição e Saúde,Universidade Federal de Viçosa,Viçosa,MG,Brazil.
Natalia Filard
NF
Tafuri
Departamento de Biologia Geral,Universidade Federal de Viçosa,Viçosa,MG,Brazil.
Sergio Luis Pinto
SL
da Matta
Departamento de Ciências Biológicas,Universidade Federal de Ouro Preto,Ouro Preto,MG,Brazil.
Maria Lucia
ML
Pedrosa
Departamento de Nutrição e Saúde,Universidade Federal de Viçosa,Viçosa,MG,Brazil.
Maria do Carmo Gouveia
Mdo C
Peluzio
D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000975:Antioxidants / Q000008:administration & dosage; D001057:Apolipoproteins E / Q000172:deficiency* / Q000502:physiology; D028023:Arecaceae; D015415:Biomarkers / Q000032:analysis; D018932:Chemokine CCL2 / Q000235:genetics; D002950:Citrate (si)-Synthase / Q000378:metabolism; D004032:Diet; D019587:Dietary Supplements; D005638:Fruit / Q000737:chemistry*; D007249:Inflammation / Q000473:pathology; D008099:Liver / Q000737:chemistry* / Q000473:pathology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009132:Muscles / Q000201:enzymology; D010084:Oxidation-Reduction; D010805:Physical Conditioning, Animal; D012333:RNA, Messenger / Q000032:analysis; D013482:Superoxide Dismutase / Q000378:metabolism
D000872:Anthocyanins; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001057:Apolipoproteins E; D015415:Biomarkers; D018932:Chemokine CCL2; D012333:RNA, Messenger; D013482:Superoxide Dismutase; D002950:Citrate (si)-Synthase