[Treatment strategy for recurrent and metastatic gastrointestinal stromal tumors].
Targeted therapy is the first line treatment for patients with recurrent/metastatic gastrointestinal stromal tumors(GIST). Sunitinib is effective for patients who have failed imatinib, specially with c-kit exon 9 gene mutation. Tyrosine kinase inhibitors combined with partial hepatectomy may increase the overall survival of GIST patients with liver metastasis. Selective patients with recurrent or metastatic GIST can benefit from surgical resection. Regorafenib and pazopanib can provide a significant improvement in progression-free survival in patients after failure of standard treatment.
Department of Gastrointestinal Surgery, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China. tjlianghan@126.com.
Han
H
Liang
D001549:Benzamides; D018572:Disease-Free Survival; D005770:Gastrointestinal Neoplasms / Q000473:pathology / Q000628:therapy*; D046152:Gastrointestinal Stromal Tumors / Q000556:secondary / Q000628:therapy*; D006498:Hepatectomy; D006801:Humans; D000068877:Imatinib Mesylate; D007191:Indazoles; D007211:Indoles; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D010671:Phenylurea Compounds; D010879:Piperazines; D011725:Pyridines; D011743:Pyrimidines; D011758:Pyrroles; D012008:Recurrence; D013449:Sulfonamides; D000077210:Sunitinib
D001549:Benzamides; D007191:Indazoles; D007211:Indoles; D010671:Phenylurea Compounds; D010879:Piperazines; D011725:Pyridines; D011743:Pyrimidines; D011758:Pyrroles; D013449:Sulfonamides; C559147:regorafenib; C516667:pazopanib; D000068877:Imatinib Mesylate; D000077210:Sunitinib