Antimicrobial activity of pantothenol against staphylococci possessing a prokaryotic type II pantothenate kinase.
Pantothenol is a provitamin of pantothenic acid (vitamin B5) that is widely used in healthcare and cosmetic products. This analog of pantothenate has been shown to markedly inhibit the phosphorylation activity of the prokaryotic type II pantothenate kinase of Staphylococcus aureus, which catalyzes the first step of the coenzyme A biosynthetic pathway. Since type II enzymes are found exclusively in staphylococci, pantothenol suppresses the growth of S. aureus, S. epidermidis, and S. saprophyticus, which inhabit the skin of humans. Therefore, the addition of this provitamin to ointment and skincare products may be highly effective in preventing infections by opportunistic pathogens.
Department of Bioresource Science, Ibaraki University College of Agriculture.
Shigeru
S
Chohnan
Misa
M
Murase
Kota
K
Kurikawa
Kodai
K
Higashi
Yuta
Y
Ogata
D000595:Amino Acid Sequence; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D053898:Biosynthetic Pathways / Q000187:drug effects; D003065:Coenzyme A / Q000096:biosynthesis; D048168:Escherichia coli K12 / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development; D006801:Humans; D008826:Microbial Sensitivity Tests; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors*; D016958:Pseudomonas putida / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development
D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D010205:Pantothenic Acid; C007288:dexpanthenol; D017853:Phosphotransferases (Alcohol Group Acceptor); C023088:pantothenate kinase; D003065:Coenzyme A