Neuroprotective effects of erythropoietin in focal brain ischemia in rats.
Neuroprotective effect of erythropoietin administered before ischemia has been previously demonstrated. The efficiency of erythropoietin administration after ischemia was not studied, though in case of success these protocols would be applied in clinical neurology. In our experiments on the model of transitory focal ischemia, erythropoietin was injected intraperitoneally during the early and delayed postischemic period (3 and 12 h). The size of the necrotic zone, neurological deficit, and the severity of brain edema were evaluated in 48 h. Injection of erythropoietin in 3 and 12 h after ischemia significantly reduced the size of necrosis (p = 0.0007 and p=0.0016, respectively), neurological deficit (p=0.0013 and p=0.0062, respectively), and brain edema (p=0.02 and p=0.0186, respectively). Injection of erythropoietin after transitory focal cerebral ischemia produced a pronounced neuroprotective effect.
I. P. Pavlov State Medical University, St. Petersburg, Russia, mprosvirnina@gmail.com.
M S
MS
Prosvirnina
A A
AA
Shmonin
E V
EV
Mel'nikova
T D
TD
Vlasov
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000473:pathology; D004921:Erythropoietin / Q000008:administration & dosage*; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D007274:Injections, Intraperitoneal; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D017208:Rats, Wistar
D018696:Neuroprotective Agents; D004921:Erythropoietin