[Determination of enantiomeric impurity in levocetirizine tablets by capillary electrophoresis].
To determine enantiomeric impurity in levocetirizine tablets by using capillary electrophoresis.



The effects of pH and the concentrations of sulfated-Β-cyclodextrin (S-Β-CD) and buffer salt on chiral resolution were examined with S-Β-CD as chiral selector.



A good enantioseparation of cetirizine was achieved with 30 mmol/L NaH2PO4 buffer solution (pH 7.0) containing 20 g/L of S-Β-CD.



The method developed in the study is sensitive and reliable for determination of enantiomeric impurity in levocetirizine tablets.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Shi-zhuo
SZ
Wang
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yun-feng
YF
Zhao
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Jia-yi
JY
Sun
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xing-jie
XJ
Guo
D017332:Cetirizine / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*; D013237:Stereoisomerism; D013607:Tablets
D013607:Tablets; C472067:levocetirizine; D017332:Cetirizine