Tripodal molecules for the promotion of phosphoester hydrolysis.
A series of low molecular weight tripodal amide/histidine-containing compounds (1-2) have been synthesised and shown to increase the rate of bis-(p-nitrophenyl) phosphate (BNPP) and soman (GD) breakdown in buffered aqueous solution.
Chemistry, University of Southampton, Southampton, UK SO17 1BJ. philip.gale@soton.ac.uk.
Jennifer R
JR
Hiscock
Mark R
MR
Sambrook
Philippa B
PB
Cranwell
Pat
P
Watts
Jack C
JC
Vincent
David J
DJ
Xuereb
Neil J
NJ
Wells
Robert
R
Raja
Philip A
PA
Gale
D000577:Amides / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D006639:Histidine / Q000737:chemistry*; D006868:Hydrolysis; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*
D000577:Amides; D004952:Esters; D009943:Organophosphorus Compounds; D006639:Histidine