A benzoic acid derivative and flavokawains from Piper species as schistosomiasis vector controls.
The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, "in silico" studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.
Laboratório de Parasitologia, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, SP, CEP 05503-900, Brazil. ludmilanr@usp.br.
Ludmila N
LN
Rapado
Research Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, Brazil. giovanacf@gmail.com.
Giovana C
GC
Freitas
Departamento de Estatística, Centro de Ciências Exatas e de Tecnologia, Universidade Federal de São Carlos, Via Washington Luís, km 235, Sao Carlos, SP, Caixa-postal 676, CEP 13565-905, Brazil. polpo@ufscar.br.
Adriano
A
Polpo
Department of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, Kr 30 45-03, Bogotá, Colombia.
Maritza
M
Rojas-Cardozo
Department of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, Kr 30 45-03, Bogotá, Colombia. jrinconv@unal.edu.co.
Javier V
JV
Rincón
Centro de Ciências Aplicadas e Educação, Universidade Federal da Paraíba, Campus IV, Rua da Mangueira, s/n, Rio Tinto, PB, CEP 5829-7000, Brazil. mtscotti@gmail.com.
Marcus T
MT
Scotti
Research Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, Brazil. majokato@iq.usp.br.
Massuo J
MJ
Kato
Laboratório de Parasitologia, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, SP, CEP 05503-900, Brazil. eliananakano@butantan.gov.br.
Eliana
E
Nakano
Research Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, Brazil.
Lydia F
LF
Yamaguchi
D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019817:Benzoic Acid / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry; D047188:Chalcones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004197:Disease Reservoirs; D006801:Humans; D020128:Inhibitory Concentration 50; D008018:Life Cycle Stages / Q000187:drug effects*; D062105:Molecular Docking Simulation; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D012550:Schistosoma mansoni / Q000502:physiology; D012552:Schistosomiasis / Q000517:prevention & control / Q000635:transmission; D012908:Snails / Q000187:drug effects* / Q000254:growth & development; D013329:Structure-Activity Relationship
D000977:Antiparasitic Agents; D001688:Biological Products; D047188:Chalcones; D010936:Plant Extracts; D019817:Benzoic Acid