ABCC8 genetic variants and risk of diabetes mellitus.
Diabetes mellitus (DM) is a major health problem worldwide and it will rapidly increase. This disease is characterized by hyperglycemia caused by defects in insulin secretion, insulin action or both. DM has three types: T1DM, T2M and gestational DM (GDM), of them T2DM is more frequent. Multiple genes and their interactions are involved in insulin secretion pathway. Sulfonylurea receptor encoded by ABCC8 gene, together with inward-rectifier potassium ion channel (Kir6.2) regulates insulin secretion by ATP-sensitive K(+) (KATP) channel located in the plasma membranes. Disruption of these molecules by different mutations is responsible for risk of DM. Several single nucleotide polymorphisms (SNPs) of ABCC8 gene and their interaction are involved in pathogenicity of DM. This review summarizes the current evidence of contribution of ABC8 genetic variants to the development of DM.
Department of Biomedical Science, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Kuala Lumpur, Malaysia.
Polin
P
Haghvirdizadeh
The Food and Drug Control Lab (FDCL), Ministry of Health, Tehran, Iran.
Monir
M
Sadat Haerian
Department of biology, Faculty of Sciences, Azad University (East branch), Tehran, Iran.
Pantea
P
Haghvirdizadeh
Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: batoolsadat@yahoo.com.
Batoul
B
Sadat Haerian
D000818:Animals; D003920:Diabetes Mellitus / Q000235:genetics* / Q000378:metabolism; D004843:Epistasis, Genetic; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D064233:Sulfonylurea Receptors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
C577507:ABCC8 protein, human; D007328:Insulin; D064233:Sulfonylurea Receptors
ABCC8; Diabetes mellitus; Polymorphism