Correlation of CD11b and CD56 expression in adult acute myeloid leukemia with cytogenetic risk groups and prognosis.
Among other phenotypic markers, CD11b expression has been considered as an unfavorable prognostic factor, both in terms of overall survival (OS), disease-free survival (DFS), and attainment and duration of complete remissions (CRs) in adult patients with acute myeloid leukemia (AML). Recently, some groups have restricted its prognostic impact to poor prognostic karyotypic risk groups. The aim of this study was to retrospectively analyze the prevalence of CD11b and of CD56 expression in blast cells of 158 AML patients [excluding those with t(15;17)] stratified according to their cytogenetic risk and to correlate these phenotypic characteristics with OS, DFS, and CR. CD11b was more frequently expressed in intermediate and unfavorable cytogenetic prognostic groups (38.9 and 35.5 %, respectively) than in the favorable group (9.5 %). No differences were observed in CD56 expression according to the cytogenetic risk groups. When OS, DFS, and CR were analyzed according to these two markers, no statistical differences were recorded in any cytogenetic risk group. In conclusion, although CD11b was more frequently expressed in blast cells of patients with intermediate and unfavorable cytogenetic risk groups, this feature did not translate into different clinical outcome. Similarly, CD56 positivity did not have any influence on the prognosis of these patients.
Hematology Department, Hospital Germans Trias i Pujol, Institut Català d'Oncologia, Institut de Recerca contra la Leucèmia Josep Carreras, Ctra del Canyet s/n, 08916, Badalona, Catalonia, Spain, jjunca@iconcologia.net.
Jordi
J
Juncà
Montse
M
Garcia-Caro
Isabel
I
Granada
Inés
I
Rodríguez-Hernández
Anna
A
Torrent
Mireia
M
Morgades
Josep-Maria
JM
Ribera
Fuensanta
F
Millá
Evarist
E
Feliu
D000293:Adolescent; D000328:Adult; D000368:Aged; D039481:CD11b Antigen / Q000235:genetics*; D019002:CD56 Antigen / Q000235:genetics*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D055815:Young Adult
D039481:CD11b Antigen; D019002:CD56 Antigen; C509295:ITGAM protein, human; C522918:NCAM1 protein, human