A single genotype of Acinetobacter baumannii expresses multiple antibiotic susceptibility phenotypes.
It is common practice to define a bacterium with unequal antibiotic susceptibility phenotypes as a different genotype. Here, we describe the utility of this practice for Acinetobacter baumannii. We determined antibiotic susceptibility for 19 clinical isolates of A baumannii. Repetitive sequence polymerase chain reaction method was used to determine genotypes. Although all isolates were of the same genotype, 79% were predicted to be different based on susceptibility patterns. The antibiotic susceptibility phenotype does not accurately predict the genotype of A baumannii.
Division of Infectious Diseases, University of Louisville School of Medicine, Louisville, KY. Electronic address: tim.wiemken@louisville.edu.
Timothy L
TL
Wiemken
Division of Infectious Diseases, University of Louisville School of Medicine, Louisville, KY.
Daniel
D
Curran
Division of Infectious Diseases, University of Louisville School of Medicine, Louisville, KY.
Robert R
RR
Kelley
Division of Infectious Diseases, University of Louisville School of Medicine, Louisville, KY.
Mohammad S S
MS
Khan
Division of Infectious Diseases, University of Louisville School of Medicine, Louisville, KY.
Ruth M
RM
Carrico
Division of Infectious Diseases, University of Louisville School of Medicine, Louisville, KY.
Emily B
EB
Pacholski
Division of Infectious Diseases, University of Louisville School of Medicine, Louisville, KY.
Julio A
JA
Ramirez
D000151:Acinetobacter Infections / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000145:classification / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D058889:Molecular Typing; D010641:Phenotype
D000900:Anti-Bacterial Agents
Antibiotype; Cohorting; Health care-associated infection; Outbreak