[Outcome and prognosis in acute myeloid leukemia patients treated with related peripheral blood hematopoietic stem cell transplantation].
This study was purposed to evaluate the outcome of acute myeloid leukemia patients treated with related peripheral blood hematopoietic stem cell transplantation (PBHSCT) and analyse the potential prognostic factors. A total of 64 acute myeloid leukemia patients treated with related peripheral allo-HSCT from march 2008 to august 2012 in our hospital were enrolled in the analysis. All the patients received either HLA-matched related or mismatched related donor mobilized peripheral blood stem cells. All the patients were followed up and evaluated for overall survival (OS), leukemia-free survival (LFS) and relapse rate (RR) , and the potential prognostic factors well analyzed. The results showed that the 3 year OS , LFS and RR were 61.9%, 52% and 39.1% respectively. Univarite analysis demonstrated that the disease status before transplantation (P < 0.01) , donor type (P < 0.01), white blood cell count at initial diagnosis (P < 0.05) are related with outcome, and severe aGVHD has some influence on the outcome (P > 0.05) . Multivariate analysis indicated the status of disease before transplantation, donor type, severe aGVHD are the most important prognostic factors. It is concluded that the related PBHSCT is effective treatment method for AML patients, recurrence is the main reason for the failure after transplantation, disease status before transplantation, donor type, and severe aGVHD are independent prognostic factors.
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Qing-Yi
QY
Zhang
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Wen-Rong
WR
Huang
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Li-Ping
LP
Dou
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Ai-Ling
AL
Deng
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Lin
L
Fu
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Ran
R
Zhang
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Xiao-Lin
XL
Lu
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Dan-Dan
DD
Li
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Yu-Yan
YY
Li
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Nan
N
Wang
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China. E-mail:chunhuiliyu@yahoo.com.
Li
L
Yu
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D011379:Prognosis; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult