Glucose Tolerance and lipid profile changes after surgical menopause.
BACKGROUND
Bilateral salpingo-oophorectomy in women may lead to metabolic consequences in patients. This study was performed to determine the glucose tolerance and lipid profile after menopause resulting from bilateral salpingo-oophorectomy.


METHODS
From September 2011 to March 2013, 31 women participants aged 46-52 years who underwent hysterectomy and bilateral salpingo-oophorectomy for benign reasons were recruited. An oral glucose tolerance test (OGTT), triglyceride (TG), total cholesterol, low density lipoproteis (LDL), high density lipoprotein (HDL) was performed before and 6 months after surgery. Fasting insulin and 2-hour insulin levels, fasting insulin / glucose indexes and homeostasis model assessment HOMA indexes were also measured.


RESULTS
The mean age of the patients was 48.6±2.9 years. The mean 2-h glucose level in OGTT changed from 26.7 before surgery to 111.1 µUnit/ml (P=0.030). The mean level of lipid profile before and after surgery for TG was 132.3 versus 181.2 mg/dl (P=0.005), total cholesterol 177.4 versus 206.7 mg/dl (P=0.0001) and LDL 98.4 versus 115.3 mg/dl (P=0.003). The other variables showed no significant difference.


CONCLUSIONS
The results indicate that lipid profile changes like increase of TG, total cholesterol and LDL should be considered before removing the ovary during hysterectomy in premenopausal women.
Fatemeh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences , Babol, Iran. ; Department of Gynacology, Babol University of Medical Sciences, Babol, Iran.
Shahla
S
Yazdani
Department of Pathology , babol University of Medical Sciences, babol , Iran.
Majid
M
Sharbatdaran
Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Mohammad
M
Abedi Samakoosh
Fatemeh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences , Babol, Iran. ; Cellular and Molecular Biology Research Center, Babol University of Medical Sciences. Babol, Iran.
Zinatossadat
Z
Bouzari
Babol University of Medical Sciences, Babol, Iran.
Zahra
Z
Masoudi
Glucose tolerance; Lipid profile; Menopause; Salpingo-oophorectomy