Three new anti-proliferative Annonaceous acetogenins with mono-tetrahydrofuran ring from graviola fruit (Annona muricata).
Bioassay-guided fractionation of the fruit powder of graviola (Annona muricata) yielded three novel compounds: muricins J, K, and L. The compounds are all C35 Annonaceous acetogenins with a mono-tetrahydrofuran ring and four hydroxyls. Their structures were elucidated by spectral methods and chemical modification after isolation via chromatographic techniques and HPLC purification. These three acetogenins demonstrated an antiproliferative against human prostate cancer PC-3 cells.
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48201, USA.
Shi
S
Sun
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48201, USA.
Jingchun
J
Liu
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48201, USA.
Hoda
H
Kadouh
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48201, USA.
Xiuxiu
X
Sun
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48201, USA. Electronic address: kzhou@wayne.edu.
Kequan
K
Zhou
D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031041:Annona / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005638:Fruit / Q000737:chemistry; D005663:Furans / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D011471:Prostatic Neoplasms / Q000188:drug therapy
D054378:Acetogenins; D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; C000601504:muricin J; C000601505:muricin K; C000601506:muricin L; C018674:tetrahydrofuran
Acetogenin; Annona muricata; Cytotoxicity; Human prostate cancer; Muricin