Methicillin-resistant Staphylococcus aureus-related septic pulmonary embolism and sacroiliitis treated with long-term linezolid in a patient with adult-onset Still's disease.
We herein report the case of a 21-year-old woman with refractory adult-onset Still's disease who developed central venous catheter-related methicillin-resistant Staphylococcus aureus sepsis during aggressive immunosuppressive therapy. She subsequently experienced septic pulmonary embolism (SPE) and sacroiliitis during treatment with intravenous vancomycin and was successfully treated with long-term oral linezolid therapy. This case suggests that the occurrence of methicillin-resistant Staphylococcus aureus infection in immunosuppressive patients can trigger severe clinical manifestations such as SPE and septic sacroiliitis and that linezolid is suitable for treating such conditions.
Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Yoshiro
Y
Horai
Koichi
K
Izumikawa
Satoru
S
Oka
Yoshikazu
Y
Nakashima
Takahisa
T
Suzuki
Hideki
H
Nakajima
Shin-ya
SY
Kawashiri
Naoki
N
Iwamoto
Kunihiro
K
Ichinose
Mami
M
Tamai
Hideki
H
Nakamura
Tomoki
T
Origuchi
Shigeru
S
Kohno
Atsushi
A
Kawakami
D000081:Acetamides / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000069349:Linezolid; D008279:Magnetic Resonance Imaging; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D023303:Oxazolidinones / Q000008:administration & dosage*; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D012338:RNA, Ribosomal, 23S; D058566:Sacroiliitis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D016706:Still's Disease, Adult-Onset / Q000150:complications*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D055815:Young Adult
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D012338:RNA, Ribosomal, 23S; D000069349:Linezolid