Effect of dietary fiber on the level of free angiotensin II receptor blocker in vitro.
The interaction between angiotensin II type 1 (AT1) receptor blockers (ARBs), such as losartan potassium (LO), candesartan (CA), and telmisartan (TE), and dietary fiber was studied as to the level of free ARB in vitro. When ARB was incubated with soluble (sodium alginate, pectin, and glucomannan) or insoluble (cellulose and chitosan) dietary fiber, the levels of free LO, TE, and CA decreased. This resulted only from mixing the dietary fiber with the ARBs and differed among the types of dietary fiber, and the pH and electrolytes in the mixture. The levels of free LO and TE tended to decrease with a higher concentration of sodium chloride in pH 1.2 fluid. These results suggest that it is important to pay attention to the possible interactions between ARBs and dietary fiber.
Faculty of Pharmaceutical Sciences, Setsunan University.
Ayano
A
Iwazaki
Kazuhiro
K
Takahashi
Yui
Y
Tamezane
Kenta
K
Tanaka
Minami
M
Nakagawa
Kimie
K
Imai
Kunio
K
Nakanishi
D047228:Angiotensin II Type 1 Receptor Blockers / Q000737:chemistry / Q000378:metabolism*; D001562:Benzimidazoles / Q000737:chemistry / Q000378:metabolism*; D001565:Benzoates / Q000737:chemistry / Q000378:metabolism*; D001713:Biphenyl Compounds; D004043:Dietary Fiber / Q000494:pharmacology*; D004573:Electrolytes; D006863:Hydrogen-Ion Concentration; D019808:Losartan / Q000737:chemistry / Q000378:metabolism*; D012965:Sodium Chloride / Q000494:pharmacology; D000077333:Telmisartan; D013777:Tetrazoles / Q000737:chemistry / Q000378:metabolism*
D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001565:Benzoates; D001713:Biphenyl Compounds; D004043:Dietary Fiber; D004573:Electrolytes; D013777:Tetrazoles; D012965:Sodium Chloride; D019808:Losartan; C081643:candesartan; D000077333:Telmisartan