Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures.
Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties.
Dipartimento di Chimica, Università di Pavia, V.le Taramelli 10, 27100, Pavia, Italy. claudia.percivalle01@universitadipavia.it angy88@tiscali.it marialucia.perrone01@universitadipavia.it mauro.freccero@unipv.it.
Claudia
C
Percivalle
Claudia
C
Sissi
Maria Laura
ML
Greco
Caterina
C
Musetti
Angelica
A
Mariani
Anna
A
Artese
Giosuè
G
Costa
Maria Lucia
ML
Perrore
Stefano
S
Alcaro
Mauro
M
Freccero
D000880:Anthraquinones / Q000737:chemistry*; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D005453:Fluorescence; D054856:G-Quadruplexes; D008024:Ligands; D008958:Models, Molecular; D019914:Taq Polymerase / Q000378:metabolism; D016615:Telomere / Q000737:chemistry*; D044366:Transition Temperature
D000880:Anthraquinones; D008024:Ligands; D004247:DNA; D019914:Taq Polymerase