Multiplexing natural orientation: oppositely directed self-assembling peptides.
We explore here the possibility that polypeptide chains with directional multiplicity might provide for the control of peptide self-assembly processes. We tested this new possibility using an oppositely directed peptide (ODP) supramolecular system. The ODP could make it possible to form a βαβ motif with antiparallel β-sheets, which does not exist in nature. Furthermore, the designed ODPs were able to self-assemble into discrete, homogeneous, and structured protein-like controlled nano-objects. ODPs represent a simple but powerful unnatural self-assembling peptide system that can become a basic scaffold for fabricating more complex and elaborate artificial nanostructures.
Translational Research Center for Protein Function Control and Department of Materials Science & Engineering, Yonsei University , Seoul 120-749, Korea.
Woo-Jin
WJ
Jeong
Sanghun
S
Han
Hyeseo
H
Park
Kyeong Sik
KS
Jin
Yong-Beom
YB
Lim
D036103:Nanotechnology / Q000379:methods*; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D053838:Scattering, Small Angle
D010455:Peptides