α-Glucosidase inhibitory activities of isoflavanones, isoflavones, and pterocarpans from Mucuna pruriens.
Three new isoflavanones (1-3) and thirteen known compounds (4-16) were isolated from the roots of Mucuna pruriens. The absolute configurations of isoflavanones 1-3 and parvisoflavanone (4), lespedeol C (5), and uncinanone C (6) were addressed by a circular dichroism technique. Isoflavanones, isoflavones, and pterocarpans of M. pruriens were found to be α-glucosidase inhibitors. Medicarpin (7) and parvisoflavone B (9) were potent α-glucosidase inhibitors (twofold less active than the standard drug acarbose). The production of bioactive metabolites in M. pruriens seems to be season-dependent.
Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand.
Tshewang
T
Dendup
Chulabhorn Research Institute, Bangkok, Thailand.
Vilailak
V
Prachyawarakorn
Chulabhorn Research Institute, Bangkok, Thailand.
Acharavadee
A
Pansanit
Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand.
Chulabhorn
C
Mahidol
Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand.
Somsak
S
Ruchirawat
Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand.
Prasat
P
Kittakoop
D002460:Cell Line; D002470:Cell Survival; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D031299:Mucuna / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D036343:Pterocarpans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012621:Seasons; D000520:alpha-Glucosidases / Q000187:drug effects* / Q000378:metabolism
D065089:Glycoside Hydrolase Inhibitors; D007529:Isoflavones; D010936:Plant Extracts; D036343:Pterocarpans; C065753:isoflavanone; D000520:alpha-Glucosidases