GM-CSF facilitates the development of inflammation-associated colorectal carcinoma.
The granulocyte macrophage colony-stimulating factor (GM-CSF) is known to play a protective role in intestinal inflammation. However, the effects of GM-CSF on the progression of colitis to colorectal carcinoma have long remained unclear. We have recently demonstrated that GM-CSF produced by colonic epithelial cells promotes colorectal tumorigenesis by stimulating the secretion of vascular endothelial growth factor.
Department of Immunology; Institute of Basic Medical Sciences; Beijing, China.
Guojiang
G
Chen
Department of Immunology; Institute of Basic Medical Sciences; Beijing, China.
Gencheng
G
Han
Department of Immunology; Institute of Basic Medical Sciences; Beijing, China.
Beifen
B
Shen
Department of Immunology; Institute of Basic Medical Sciences; Beijing, China.
Yan
Y
Li
GM-CSF; VEGF; colitis; colonic epithelial cell; colorectal carcinoma