Clinical utility of circulating tumor cell counting through CellSearch(®): the dilemma of a concept suspended in Limbo.
To date, 10 years after the first demonstration of circulating tumor cells (CTCs), prognostic significance in metastatic breast cancer using the US Food and Drug Administration-cleared system CellSearch(®), the potential utility of CTCs in early clinical development of drugs, their role as a surrogate marker of response to therapy, and their molecular analysis for patient stratification for targeted therapies are still major unsolved questions. Great expectations are pinned on the ongoing interventional trials aimed to demonstrate that CTCs might be of value for guiding treatment of patients and predicting cancer progression. To fill the gap between theory and practice with regard to the clinical utility of CTCs, a bridge is needed, taking into account innovative design for clinical trials, a revised definition of traditional CTCs, next-generation CTC technology, the potential clinical application of CTC analysis in non-validated settings of disease, and finally, expanding the number of patients enrolled in the studies. In this regard, the results of the first European pooled analysis definitely validated the independent prognostic value of CTC counting in metastatic breast cancer patients.
Dipartimento Medicina Molecolare, Sapienza Università di Roma, Rome, Italy.
Cristina
C
Raimondi
Dipartimento Medicina Molecolare, Sapienza Università di Roma, Rome, Italy.
Angela
A
Gradilone
Dipartimento di Scienze Radiologiche, Oncologiche e Anatomopatologiche, Sapienza Università di Roma, Rome, Italy.
Giuseppe
G
Naso
Dipartimento di Scienze Radiologiche, Oncologiche e Anatomopatologiche, Sapienza Università di Roma, Rome, Italy.
Enrico
E
Cortesi
Dipartimento Medicina Molecolare, Sapienza Università di Roma, Rome, Italy.
Paola
P
Gazzaniga
CTC; clinical trials; prognosis