Auto-immune hepatitis following delivery.
Auto-immune hepatitis first presenting in the early postpartum period is rare. Immunosuppressive effects of pregnancy result in delayed manifestation of auto-immune hepatitis, and in established cases, the spontaneous improvements are there. Auto-immune hepatitis should be considered in the differential diagnosis of liver dysfunction first presenting in the early postpartum period. A case of postpartum hepatitis of auto-immune aetiology is being presented here. It is disease of unknown aetiology, characterised by inflammation of liver (as evidenced by raised serum transaminases, presence of interface hepatitis on histological examination), hypergammaglobulinaemia (> 1.5 times normal), presence of auto-antibodies [(antinuclear antibodies (ANA)], smooth muscle antibody (SMA) and antibody to liver-kidney microsome type 1 (LKM1) in the absence of viral markers ie, hepatitis B (HBsAg) and C (AntiHCV) and excellent response to corticosteroid therapy.
Vandana
V
Saini
Mamta
M
Gupta
S K
SK
Mishra
D005260:Female; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006801:Humans; D011644:Puerperal Disorders / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D055815:Young Adult