Association of IGF1R polymorphisms with the development of HBV-related hepatocellular carcinoma.
Although the involvement of insulin-like signaling in cancer has been well documented in various types of cancers, the association between the genetic variants in the insulin-like signaling and the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains unclear. In this study, a total of 498 individuals including 173 HBV related cirrhosis patients, 171 HBV-related HCC patients, and 154 healthy controls were enrolled. Sixteen single nucleotide polymorphisms (SNPs) in IGF1, IGF2, IGF1R and IGF2R have been genotyped by employing SNaPshot assays. We found A/A genotype at rs3743251 of IGF1R was negatively associated with HBV related HCC [odds ratio (OR) = 0.38, 95% confidence interval (CI) = 0.20-0.72, P = 0.037]; A/G genotype decreased the risk of portal vein thrombosis (OR = 0.38, 95%CI = 0.18-0.82, P = 0.01). These results indicate that rs3743251 polymorphism in IGF1R is associated with the susceptibility of HBV-related HCC.
Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. Key Laboratory of Organ Transplantation, Collaborative innovation center for Diagnosis treatment of infectious diseases, Zhejiang University School of Medicine, Hangzhou, China.
H-Y
HY
Xie
C-Y
CY
Xing
B-J
BJ
Wei
X
X
Xu
J
J
Wu
L-M
LM
Chen
G-Q
GQ
Cao
H
H
Chen
K-J
KJ
Chen
S-Y
SY
Yin
L-M
LM
Wu
L
L
Zhou
S-S
SS
Zheng
D000328:Adult; D000368:Aged; D063646:Carcinogenesis / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006515:Hepatitis B virus / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics* / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017526:Receptor, IGF Type 1; D017451:Receptors, Somatomedin / Q000235:genetics; D012306:Risk
C000597236:IGF1R protein, human; D017451:Receptors, Somatomedin; D017526:Receptor, IGF Type 1
HBV; HCC; IGF1R; insulin-like signaling; polymorphism