Prevalence and correlates of vitamin K deficiency in children with inflammatory bowel disease.
Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence in pediatric IBD remains unknown. We carried out a cross-sectional study in 63 children with Crohn's disease (CD) and 48 with ulcerative colitis (UC) to assess the prevalence of vitamin K deficiency and to search for potential correlation between vitamin K status and pediatric IBD activity. Vitamin K status was assessed using protein induced by vitamin K absence-II (PIVKA-II; ELISA). Prevalence of vitamin K deficiency was 54.0% in CD and 43.7% in UC. Vitamin K deficiency was more common in patients with higher CD activity, in CD patients with higher mass Z-scores, and less common among children with CD treated with infliximab. Relation of vitamin K deficiency to pediatric IBD clinical course and treatment demand further research.
Poznan University of Medical Sciences, Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland.
Jan K
JK
Nowak
Medical University of Silesia, Department of Paediatrics, Katowice, Poland.
Urszula
U
Grzybowska-Chlebowczyk
Medical University of Gdansk, Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Gdansk, Poland.
Piotr
P
Landowski
Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Department of Pediatric Endoscopy and Gastrointestinal Function Testing, Bydgoszcz, Poland.
Anna
A
Szaflarska-Poplawska
Poznan University of Medical Sciences, Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland.
Beata
B
Klincewicz
Poznan University of Medical Sciences, Poznan, Poland.
Daria
D
Adamczak
Poznan University of Medical Sciences, Department of General, Gastroenterological and Endocrinological Surgery, Poznan, Poland.
Tomasz
T
Banasiewicz
Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Andrzej
A
Plawski
Poznan University of Medical Sciences, Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland.
Jaroslaw
J
Walkowiak
D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D015415:Biomarkers / Q000097:blood*; D015519:Bone Density; D002648:Child; D003093:Colitis, Ulcerative / Q000097:blood* / Q000150:complications / Q000473:pathology; D003424:Crohn Disease / Q000097:blood* / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D000069285:Infliximab; D008297:Male; D011498:Protein Precursors / Q000097:blood*; D011516:Prothrombin; D012307:Risk Factors; D012720:Severity of Illness Index; D014812:Vitamin K / Q000378:metabolism; D014813:Vitamin K Deficiency / Q000097:blood* / Q000150:complications
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D011498:Protein Precursors; D014812:Vitamin K; C008208:acarboxyprothrombin; D011516:Prothrombin; D000069285:Infliximab