Weekly teriparatide administration for the treatment of delayed union: a report of two cases.
Two cases of delayed union that were effectively treated with weekly TPTD administration are described. The effect of this therapy was observed within 4 weeks.


BACKGROUND
In the first case, a 72-year-old woman underwent osteotomy for the treatment of hallux valgus. Bone union was still not observed 4 months after surgery. Therefore, weekly teriparatide (56.5 mg) injections were administered, resulting in the initiation of bone union within 4 weeks and complete bone union 4 months after the first teriparatide injection. In the second case, a 72-year-old woman underwent open reduction and internal fixation of an olecranon fracture. Bone union was delayed 4 months after surgery; therefore, weekly teriparatide (56.5 mg) injections were started.


RESULTS
The initiation of bone union was slightly evident within 4 weeks, and complete healing was achieved 4 months after the first teriparatide injection. In both cases, no serious teriparatide-related adverse effects were observed.


CONCLUSIONS
Weekly teriparatide administration was effective for bone healing and useful for delayed union; moreover, the effect of this therapy showed within 4 weeks.
Department of Orthopedic Surgery, Japanese Red Cross Kyoto Daini Hospital, 355-5 Haruobi-cho, Kamanza, Marutamachi, Kamigyo-ku, Kyoto, 602-8026, Japan, tachy_ortho@yahoo.co.jp.
Hisakazu
H
Tachiiri
Yoshiki
Y
Okuda
Takahito
T
Yamasaki
Torao
T
Kusakabe
D000368:Aged; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D017102:Fracture Healing / Q000187:drug effects*; D005599:Fractures, Ununited / Q000188:drug therapy / Q000503:physiopathology; D006215:Hallux Valgus / Q000601:surgery; D006801:Humans; D056740:Olecranon Process / Q000293:injuries; D010027:Osteotomy / Q000379:methods; D011183:Postoperative Complications / Q000188:drug therapy / Q000503:physiopathology; D019379:Teriparatide / Q000008:administration & dosage*; D014458:Ulna Fractures / Q000188:drug therapy / Q000503:physiopathology
D050071:Bone Density Conservation Agents; D019379:Teriparatide