LL37 peptide@silver nanoparticles: combining the best of the two worlds for skin infection control.
Capping silver nanoparticles with LL37 peptide eradicates the antiproliferative effect of silver on primary skin cells, but retains the bactericidal properties of silver nanoparticles with activities comparable to silver nitrate or silver sulfadiazine. In addition, LL37 capped silver nanoparticles have anti-biofilm formation activity.
Department of Chemistry and Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada. emilio@photo.chem.uottawa.ca scaiano@photo.chem.uottawa.ca.
Mariana
M
Vignoni
Hasitha
H
de Alwis Weerasekera
Madeline J
MJ
Simpson
Jaywant
J
Phopase
Thien-Fah
TF
Mah
May
M
Griffith
Emilio I
EI
Alarcon
Juan C
JC
Scaiano
D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D008826:Microbial Sensitivity Tests; D012834:Silver / Q000737:chemistry*; D012867:Skin / Q000166:cytology / Q000382:microbiology; D014466:Ultraviolet Rays
D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins; D012834:Silver