[Study on preparation of salvianolic acid phospholipid compound].
To prepare salvianolic acid phospholipid compound. With the compound of salvianolic acids and soybean phospholipid as the index, mono-factor experiment and orthogonal design experiment were conducted to screen its technical parameters. According to the results, the optimal preparation conditions of salvianolic acid phospholipid compound were that THF were taken as the reaction solvent, the concentration time was 3 h, the reactant concentration was 5 g x L(-1), the mass ratio of salvianolic acids and phospholipid was 1: 1.5, and the reaction temperature was 40 degrees C. The oil/water partition coefficient of the prepared salvianolic acid phospholipid compound significant increased in water and buffers with different pH values. The results of phase analysis such as DSC, XRD and FTIR indicated that salvianolic acids existed in phospholipid in an amorphous state.
Xiao-Yun
XY
Chen
Zhen-Hai
ZH
Zhang
Dan
D
Liu
Dan-Hong
DH
Yu
E
E
Sun
Xiao-Bin
XB
Jia
D000475:Alkenes / Q000737:chemistry* / Q000378:metabolism; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D007408:Intestinal Absorption; D010743:Phospholipids / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry* / Q000378:metabolism; D013025:Glycine max / Q000737:chemistry; D013696:Temperature
D000475:Alkenes; D010743:Phospholipids; D059808:Polyphenols; C568740:salvianolic acid