Testosterone changes in patients with liver cirrhosis before and after orthotopic liver transplantation and its correlation with MELD.
BACKGROUND
Hypogonadism is a common clinical situation in male patients with liver cirrhosis.


OBJECTIVE
The aim of the present study was to evaluate the effects of orthotopic liver transplantation on testosterone, free testosterone and sex hormone-binding globulin in male with advanced liver disease and also to determine the relationship of these changes with Model for End-stage Liver Disease (MELD) score.


METHODS
In a prospective study, serum levels of testosterone, free testosterone and sex hormone-binding globulin of 30 male adult patients with end-stage liver disease were measured 2 to 4 hours before and 6 months after orthotopic liver transplantation.


RESULTS
Total testosterone levels increased after orthotopic liver transplantation and the number of patients with normal testosterone levels increased from 18 to 24. Free testosterone mean level in the pre-transplant group was 7.8 pg/mL and increased to 11.5 pg/mL (P = 0.10) and sex hormone-binding globulin level decreased after orthotopic liver transplantation returning to normal levels in MELD ≤ 18 - group (A) (P<0.05).


CONCLUSIONS
Serum level changes of testosterone, free testosterone and sex hormone-binding globulin are more pronounced in cirrhotic males with MELD ≤ 18. Serum levels of testosterone and free testosterone increase and serum levels of sex hormone-binding globulin decrease after orthotopic liver transplantation.
Departamento de Transplante Hepático, Universidade Federal do Parana, Curitiba, PR, Brasil.
Rodrigo
R
Nitsche
Departamento de Transplante Hepático, Universidade Federal do Parana, Curitiba, PR, Brasil.
Júlio Cezar Uili
JC
Coelho
Departamento de Transplante Hepático, Universidade Federal do Parana, Curitiba, PR, Brasil.
Alexandre Coutinho Teixeira de
AC
Freitas
Departamento de Transplante Hepático, Universidade Federal do Parana, Curitiba, PR, Brasil.
Clementino
C
Zeni Neto
Departamento de Transplante Hepático, Universidade Federal do Parana, Curitiba, PR, Brasil.
Eduardo
E
Martins
D000328:Adult; D058625:End Stage Liver Disease; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013739:Testosterone / Q000097:blood*
D012738:Sex Hormone-Binding Globulin; D013739:Testosterone