Thyroid Cancer: Role of RET and Beyond.
Specific thyroid cancer histotypes, such as papillary and medullary thyroid carcinoma, display genetic rearrangements or point mutations of the RET gene, resulting in its oncogenic conversion. The molecular mechanisms mediating RET rearrangement with other genes and the role of partner genes in tumorigenesis have been described. In addition, the RET protein has become a molecular target for medullary thyroid carcinoma treatment.
Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, Università degli Studi di Napoli Federico II, Napoli, Italia.
Francesca
F
Carlomagno
Chromosome rearrangements; RET; Receptor tyrosine kinase; Thyroid cancer; Tyrosine kinase inhibitors