Serum uric acid concentration is linked to wearing-off fluctuation in Japanese Parkinson's disease patients.
BACKGROUND
Serum uric acid (UA) concentration is linked to the risk of progression of Parkinson's disease (PD).


OBJECTIVE
The aim of this study was to examine the association between serum UA concentration and the occurrence of wearing-off fluctuation (WOF) in Japanese PD patients.


METHODS
A total of 123 Japanese patients with PD were enrolled in this study. We collected data on demographics, clinical features, medications, and laboratory findings including serum UA concentration, and examined the presence of WOF. The association between serum UA concentration and WOF was assessed using multivariate logistic regression analysis.


RESULTS
After adjusting for possible confounders, it was found that the odds ratio (OR) for WOF decreased with increasing quartile of UA (highest quartile vs. lowest quartile, adjusted OR 0.218, 95% confidence interval [CI] 0.053-0.891). This association was significant only in male PD patients, regardless of the use of sex-specific quartiles of UA. Additionally, disease duration (OR 7.80, 95% CI 2.62-23.17) and daily levodopa dosage (OR 4.06, 95% CI 1.45-11.38) were associated with the occurrence of WOF.


CONCLUSIONS
Our results showed that serum UA concentration was associated with the occurrence of WOF. Serum UA concentration may be a predictive factor for WOF.
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan.
Jiro
J
Fukae
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Kei-Ichi
K
Ishikawa
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Taku
T
Hatano
Department of Neurology, Juntendo University Koshigaya Hospital, Koshigaya, Japan.
Asako
A
Yoritaka
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Masashi
M
Takanashi
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Yasushi
Y
Shimo
Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan.
Jun
J
Tsugawa
Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan.
Yoshio
Y
Tsuboi
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Nobutaka
N
Hattori
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D018450:Disease Progression; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000503:physiopathology*; D044967:Serum; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid
Parkinson's disease; sex difference; uric acid; wearing-off fluctuation