Evaluation of poly(2-ethyl-2-oxazoline) containing copolymer networks of varied composition as sustained metoprolol tartrate delivery systems.
Segmented copolymer networks (SCN) based on poly(2-ethyl-2-oxazoline) and containing 2-hydroxyethyl methacrylate, 2-hydroxypropyl acrylate, and/or methyl methacrylate segments have been evaluated as potential sustained release systems of the water soluble cardioselective β-blocker metoprolol tartrate. The structure and properties of the drug carriers were investigated by differential scanning calorimetry, attenuated total reflectance Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy. Swelling kinetics of SCNs in various media was followed, and the conditions for effective MT loading were specified. MT-loaded SCNs with drug content up to 80 wt.% were produced. The release kinetics of metoprolol tartrate from the systems was studied and it was shown that the conetworks of different structure and composition are able to sustain the metoprolol tartrate release without additional excipients.
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University - Sofia, 2 Dunav Str., Sofia, 1000, Bulgaria, bistrakostova@abv.bg.
Bistra
B
Kostova
Sijka
S
Ivanova
Konstantin
K
Balashev
Dimitar
D
Rachev
Darinka
D
Christova
D002152:Calorimetry, Differential Scanning / Q000379:methods; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D007700:Kinetics; D008790:Metoprolol / Q000737:chemistry*; D018625:Microscopy, Atomic Force / Q000379:methods; D008855:Microscopy, Electron, Scanning / Q000379:methods; D011073:Polyamines / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011073:Polyamines; D011108:Polymers; C511916:poly(2-ethyl-2-oxazoline); D008790:Metoprolol