Evaluation of plasma chemerin levels in patients with non-dipper blood pressure patterns.
BACKGROUND
Chemerin is a novel adipokine that plays a role in inflammation and atherosclerosis. Although there are several correlations between hypertension and the inflammatory system, there is still insufficient information about the relationship between blood pressure variability and inflammatory markers. In this study, we aimed to determine whether chemerin levels are elevated in non-dipper patients compared with dippers and healthy controls.


METHODS
This study was composed of a group of 90 patients: 60 hypertensive patients and 30 healthy control subjects (12 males, mean age 53.2 ± 15.4 years). Ambulatory blood pressure monitoring devices (ABPM) were connected to all patients. Using data from the ABPM, hypertensive patients were divided into 2 groups: 30 dipper patients (12 males, mean age 52.5 ± 15.1 years) and 30 non-dipper patients (11 males, mean age 54.6 ± 13.0 years). Complete blood count and biochemistry were measured by standard methods and plasma chemerin concentrations were quantified by ELISA.


RESULTS
Non-dipper patients demonstrated higher chemerin levels compared to dippers and normotensives (219.7 ± 16.3 vs. 182.4 ± 21.4 ng/ml; 219.7 ± 16.3 vs. 85.4 ± 38.1 ng/ml, respectively, p<0.001 for both comparisons). A receiver operating characteristic curve analysis revealed that the optimal cut-off value for chemerin to predict a non-dipping pattern was 201.4, with 90% sensitivity and 90% specificity. There was a positive correlation between chemerin levels and all ambulatory blood pressure values in all hypertensive patients.


CONCLUSIONS
Chemerin, which plays a role in inflammation and atherosclerosis, was higher in non-dippers compared to dippers and normotensives. Additionally, chemerin shows positive correlations with blood pressure.
Department of Cardiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.
Murat
M
Meric
Department of Cardiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.
Korhan
K
Soylu
Department of Biochemistry, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.
Bahattin
B
Avci
Department of Cardiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.
Serkan
S
Yuksel
Department of Cardiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.
Okan
O
Gulel
Department of Cardiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.
Mustafa
M
Yenercag
Department of Cardiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.
Metin
M
Coksevim
Department of Cardiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.
Adem
A
Uzun
D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D012372:ROC Curve
D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human