Hypolipidemic and hypoglycemic effect of peptide Lys-Glu-Trp-NH(2) in rats with associated metabolic disorders.
The effect of peptide Lys-Glu-Trp-NH2 in doses of 0.2, 20, and 2000 μg/kg on lipid and carbohydrate metabolism was studied in Wistar rats with experimental hyperlipidemia and diabetes mellitus. This tripeptide in a dose of 2000 μg/kg produced a hypolipidemic effect on atherogenic lipoproteins, decreased the intensity of LPO, improved the state of the antioxidant system, and normalized the content of HDL. Treatment with this tripeptide had a hypolipidemic effect and reduced the severity of specifi c morphofunctional changes in the pancreatic and hepatic tissue.
Cytomed Medical-Biological Research and Production Complex, St. Petersburg, Russia, vvm-61@mail.ru.
V V
VV
Malinin
T N
TN
Savateeva-Lyubimova
K V
KV
Sivak
D000818:Animals; D006943:Hyperglycemia / Q000150:complications / Q000188:drug therapy*; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy*; D008659:Metabolic Diseases / Q000150:complications / Q000188:drug therapy*; D009842:Oligopeptides / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D009842:Oligopeptides