Multiple facets of TPP1 in telomere maintenance.
Telomeres are nucleoprotein complexes that cap the ends of all linear chromosomes and function to prevent aberrant repair and end-to-end chromosome fusions. In somatic cells, telomere shortening is a natural part of the aging process as it occurs with each round of cell division. In germ and stem cells, however, the enzyme telomerase synthesizes telomere DNA to counter-balance telomere shortening and help maintain cellular proliferation. Of the primary telomere end-binding proteins, TPP1 has recently emerged as a primary contributor in protecting telomere DNA and in recruiting telomerase to the telomere ends. In this review, we summarize the current knowledge regarding the role of TPP1 in telomere maintenance.
Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland OH 44106, USA.
Malligarjunan
M
Rajavel
Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland OH 44106, USA.
Michael R
MR
Mullins
Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland OH 44106, USA; Department of Biochemistry, Case Western Reserve University, School of Medicine, Cleveland OH 44106, USA. Electronic address: derek.taylor@case.edu.
Derek J
DJ
Taylor
D000818:Animals; D016798:Ciliophora / Q000235:genetics / Q000378:metabolism; D004277:DNA, Single-Stranded / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D011485:Protein Binding; D017386:Sequence Homology, Amino Acid; D000089804:Shelterin Complex; D019098:Telomerase / Q000235:genetics* / Q000378:metabolism; D016615:Telomere; D059505:Telomere Homeostasis / Q000235:genetics*; D034501:Telomere-Binding Proteins / Q000235:genetics* / Q000378:metabolism
C495876:ACD protein, human; D004277:DNA, Single-Stranded; D000089804:Shelterin Complex; D034501:Telomere-Binding Proteins; D019098:Telomerase
Chromosome stability; DNA damage; Shelterin; TPP1; Telomerase; Telomere