Optimal aspirin dose in acute coronary syndromes: an emerging consensus.
Numerous clinical trials testing the efficacy of aspirin for the secondary prevention of cardiovascular disease have been published. We reviewed the literature pertaining to aspirin dose in acute coronary syndrome patients. Clinical trials assessing the comparative efficacy of different doses of aspirin are scarce. This complex antiplatelet therapy landscape makes it difficult to identify the best aspirin dose for optimizing efficacy and minimizing risk of adverse events, while complying with the various guidelines and recommendations. Despite this fact, current evidence suggests that aspirin doses of 75-100 mg/day may offer the optimal benefit:risk ratio in acute coronary syndrome patients.
Saint Luke's Mid America Heart Institute, Kansas City, MO, USA.
James J
JJ
DiNicolantonio
Nicholas B
NB
Norgard
Pascal
P
Meier
Carl J
CJ
Lavie
James H
JH
O'Keefe
Asfandyar K
AK
Niazi
Saurav
S
Chatterjee
Kathleen A
KA
Packard
Fabrizio
F
D'Ascenzo
Enrico
E
Cerrato
Giuseppe
G
Biondi-Zoccai
Sripal
S
Bangalore
Flavio D
FD
Fuchs
Victor L
VL
Serebruany
D054058:Acute Coronary Syndrome / Q000628:therapy*; D000241:Adenosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D001241:Aspirin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D009203:Myocardial Infarction / Q000517:prevention & control; D062645:Percutaneous Coronary Intervention; D010879:Piperazines / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D017410:Practice Guidelines as Topic; D000068799:Prasugrel Hydrochloride; D058921:Purinergic P2Y Receptor Antagonists / Q000627:therapeutic use; D055502:Secondary Prevention; D013876:Thiophenes / Q000627:therapeutic use; D000077486:Ticagrelor
D010879:Piperazines; D010975:Platelet Aggregation Inhibitors; D058921:Purinergic P2Y Receptor Antagonists; D013876:Thiophenes; D000068799:Prasugrel Hydrochloride; D000077486:Ticagrelor; D000241:Adenosine; D001241:Aspirin