Intake of Tibetan hull-less barley is associated with a reduced risk of metabolic related syndrome in rats fed high-fat-sucrose diets.
The objective of this study was to assess the effects of whole grain Tibetan hull-less barley on metabolic related syndrome induced by high-fat-sucrose diets in rats. The diets were designed to reflect the dietary patterns of Chinese individuals (>30% energy fat) with refined wheat flour (HFS-W) or Tibetan hull-less barley (HFS-THB) as the main carbohydrate sources. Rats fed HFS-W had increased body weight, abdominal fat deposition, liver weight, liver fat deposition, triglyceride (TG), fasting blood glucose (FBG), serum fasting insulin (FINS), and homeostasis model assessment of insulin resistance (HOMA-IR) scores, and decreased low-density lipoprotein cholesterol (LDL-C) levels compared to rats fed a basal diet (BD). However, rats fed HFS-THB had reduced body weight gain, dyslipidemia, and insulin resistance. These findings indicate that whole Tibetan hull-less barley is a functional food that can reduce the prevalence of metabolic related syndrome induced by high-fat-sucrose diets.
Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China. samfy007@hotmail.com.
Lingxiao
L
Gong
Department of Neurology, Huashan Hospital, Jingan 200040, Shanghai, China. 10913031@zju.edu.cn.
Lingyun
L
Gong
Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China. yzhang@zju.edu.cn.
Ying
Y
Zhang
D050153:Abdominal Fat / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000008:administration & dosage; D019422:Dietary Sucrose / Q000008:administration & dosage*; D050171:Dyslipidemias / Q000178:diet therapy / Q000517:prevention & control; D055951:Functional Food; D001467:Hordeum / Q000737:chemistry*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000517:prevention & control*; D064209:Phytochemicals / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain; D015431:Weight Loss
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D019422:Dietary Sucrose; D007328:Insulin; D064209:Phytochemicals; D014280:Triglycerides