Therapeutic effect of taurine against aluminum-induced impairment on learning, memory and brain neurotransmitters in rats.
The aim of the study was to demonstrate the therapeutic effect of taurine against aluminum (Al)-induced neurological disorders in rats. Forty-two Wistar rats were randomly allotted into six groups: control (saline only), Al exposure (281.4 mg/kg/day for 1 month), Al + taurine (Al administration as previously plus taurine, doses were 200, 400 and 800 mg/kg/day, respectively, for the next 1 month) and prevention group (along with the Al administration as previously, 400 mg/kg/day taurine was treated for 1 month. During the next 1 month, rats were given taurine 400 mg/kg/day only). Starting from the sixth week, the body weight gain was significantly reduced in Al exposure group compared with saline (P < 0.05), and at the eighth week, the gain in prevention group was increased compared with Al (P < 0.05). Brain coefficient was gained in Al exposure compared with saline or prevention group (P < 0.05). Al exposure resulted in learning and memory impairment by increasing the escape latency and searching distance, meanwhile, decreasing the swimming time in the quadrant of platform and the numbers of crossing the platform (P < 0.05). Unsurprisingly, taurine treatment (400, 800 mg/kg/day and prevention) significantly protected against Al-induced brain dysfunction (P < 0.05). The Al exposure led to significant decreases in levels of γ-GABA and Tau, meanwhile, increased in level of Asp and Glu compared with saline (P < 0.05). And yet, taurine treatment partially reversed the deteriorated changes. The results suggested that taurine probably has neuroprotective effect against Al-induced learning, memory and brain neurotransmitters dysfunction.
Department of Hygiene Detection, College of Public Health, University of Shandong, Jinan, China.
Lu
L
Wenting
Liu
L
Ping
Jiao
J
Haitao
Qiao
Q
Meng
Ren
R
Xiaofei
D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000633:toxicity*; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002712:Chlorides / Q000633:toxicity*; D007859:Learning Disabilities / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D065854:Spatial Navigation / Q000187:drug effects; D013654:Taurine / Q000008:administration & dosage*
D017607:Aluminum Compounds; D000596:Amino Acids; D002712:Chlorides; D018696:Neuroprotective Agents; D013654:Taurine; D000077410:Aluminum Chloride