Validation of the disease risk index for outcome of patients undergoing allogeneic hematopoietic stem cell transplantation after T cell depletion.
Identification of pretransplantation risk factors is important in evaluating patient outcomes after hematopoietic stem cell transplantation. Current scoring schemes, such as the European Group for Blood and Marrow Transplantation risk score or the Hematopoietic Cell Transplantation-Specific Comorbidity Index, may under-rate disease and disease status at the time of transplantation. The recently published Disease Risk Index (DRI) specifically investigates these aspects by defining 4 risk groups (low, intermediate, high, very high) with significant differences in overall survival (OS). We retrospectively investigated whether the DRI could be applied at the transplantation center of Geneva's University Hospitals (Geneva, Switzerland), where 64% of patients are underwent transplantation with T cell-depleted grafts (TDEP). We analyzed 409 patients with various hematological malignancies who underwent transplantation between January 1998 and October 2012. Using the DRI, the 4-year OS for the low, intermediate, high, and very high groups was 82%, 53%, 27%, and 31%, respectively (P < .0001). For TDEP patients, the 4-year OS for low, intermediate, and high overall risk groups was 86%, 53%, and 33%, respectively (P < .0001). As patients in the very high overall risk group are usually not eligible for TDEP, our group comprised too few patients (n = 3) for meaningful analysis. For non-TDEP patients, the 4-year OS for low, intermediate, high, and very high overall risk groups was 63%, 54%, 22%, and 18%, respectively (P < .0001). Our results confirm the prognostic value of the DRI in a cohort with a majority of TDEP patients.
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland.
Yan
Y
Beauverd
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland.
Eddy
E
Roosnek
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland.
Yordanka
Y
Tirefort
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland.
Monika
M
Nagy-Hulliger
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland.
Michael
M
Bernimoulin
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland.
Olga
O
Tsopra
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland.
Marc
M
Ansari
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland.
Carole
C
Dantin
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland.
Alessandro
A
Casini
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland.
Anne-Pascale
AP
Grandjean
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland.
Ekaterina
E
Chigrinova
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland.
Stavroula
S
Masouridi-Levrat
Stem Cell Transplant Team, Division of Hematology, Geneva's University Hospitals and University of Geneva Faculty of Medicine, Geneva, Switzerland. Electronic address: yves.chalandon@hcuge.ch.
Yves
Y
Chalandon
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008212:Lymphocyte Depletion; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods*; D016896:Treatment Outcome; D054928:Validation Studies as Topic; D055815:Young Adult
Disease Risk Index; Hematopoietic stem cell transplantation; Overall survival; Prognosis