Copper-catalyzed oxidative C-O bond formation of 2-acyl phenols and 1,3-dicarbonyl compounds with ethers: direct access to phenol esters and enol esters.
A copper-catalyzed oxidative coupling of 2-carbonyl-substituted phenols and 1,3-dicarbonyl compounds with a wide range of dibenzyl or dialkyl ethers is described. This protocol provides an efficient preparation of phenol esters and enol esters in good yields with high chemoselectivity. This method represents an alternative protocol for classical esterification reactions.
School of Pharmacy, Sungkyunkwan University , Suwon 440-746, Republic of Korea.
Jihye
J
Park
Sang Hoon
SH
Han
Satyasheel
S
Sharma
Sangil
S
Han
Youngmi
Y
Shin
Neeraj Kumar
NK
Mishra
Jong Hwan
JH
Kwak
Cheong Hoon
CH
Lee
Jeongmi
J
Lee
In Su
IS
Kim
D001593:Benzyl Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004951:Esterification; D004952:Esters; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry*
D001593:Benzyl Compounds; D004952:Esters; D004987:Ethers; D010636:Phenols; D003300:Copper