Isolated hepatic sarcoidosis.
BACKGROUND
Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Although hepatic granulomas occur in 50-65% of patients with systemic sarcoidosis, isolated liver sarcoidosis is rare. Clinical presentation varies from asymptomatic to manifest. The diagnosis is based on a characteristic histopathological finding of liver biopsy.


METHODS
We reported a 69-year old man was admitted due to abdominal swelling and abdominal pain. Laboratory studies detected: cholestasis, pancytopenia and elevaton of angiotensin-converting enzyme. Abdominal imaging techniques showed liver cirrhosis, splenomegaly and ascites. The diagnosis of the hepatic sarcoidosis was confirmed by histopathological examination of liver biopsy. The patient was treated with corticosteroids. After 18 months the patient was without any subjective symptoms, and with biochemical and clinical improvement.


CONCLUSIONS
Isolated hepatic sarcoidosis should be considered in the differential diagnosis of asymptomatic or simptomatic patients with hepatosplenomegaly and changes in liver functional tests. Only the timely diagnosis and proper treatment can lead to subjective and objective improvement of patients.
Ivana
I
Jovicić
Duaan Dj
DDj
Popović
Ljubisa
L
Toncev
Zikica
Z
Jovicić
Violeta
V
Vucnić
Nada
N
Kovacević
Srdjan
S
Djuranović
Ivan
I
Boricić
Marjan
M
Micev
Milan
M
Spuran
Tomica
T
Milosavljević
D015746:Abdominal Pain / Q000209:etiology; D000368:Aged; D001201:Ascites / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D001706:Biopsy; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D013163:Splenomegaly / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D016896:Treatment Outcome
D005938:Glucocorticoids