Synthesis of new 5-substituted hydantoins and symmetrical twin-drug type hydantoin derivatives.
In connection with our studies on hydantoin derivatives, a conventional regioselective chemical transformation of 5-methylene hydantoins 4a-c to 5-aminomethyl-substituted hydantoins 5-10 or to 5-amino-5-methyl-disubstituted hydantoins 11-14 is described. Synthesis of bivalent twin-drug type hydantoin derivatives 19-24 and the binding property of a bivalent symmetrical hydantoin derivative 24b to sulfated glycosaminoglycans are also described.
Faculty of Pharmaceutical Sciences, Fukuoka University.
Fumiko
F
Fujisaki
Hatsumi
H
Aki
Ayumi
A
Naito
Enko
E
Fukami
Nobuhiro
N
Kashige
Fumio
F
Miake
Kunihiro
K
Sumoto
D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D006827:Hydantoins