Long-term efficacy of selective laser trabeculoplasty in patients on prostaglandin therapy.
BACKGROUND
The aim of the study was to analyse the efficacy of selective laser trabeculoplasty in patients on medical therapy and to evaluate a possible influence of prostaglandin therapy on intraocular pressure reduction.


METHODS
A retrospective chart review was undertaken of patients with ocular hypertension or open angle glaucoma who underwent selective laser trabeculoplasty between 3/2008 and 12/2010. Data were collected preoperatively, on the day of intervention, 1 day, 1 month and then every 3 months post selective laser trabeculoplasty. The main outcome measure was mean intraocular pressure reduction.


RESULTS
109 eyes (76 on prostaglandins) were included. Mean preoperative intraocular pressure was 22.3 ± 4.5 mmHg (prostaglandin naïve) and 19.2 ± 4.8 mmHg (on prostaglandin) (p=0.003). Up to 1 year follow-up, intraocular pressure was statistically significantly reduced in both groups (p ≤ 0.019). Eyes with a higher preoperative intraocular pressure had a greater pressure reduction (Spearman rho=0.387, p=0.002). Eyes naïve to prostaglandins initially had a greater reduction in intraocular pressure, although after 1 year of follow-up the difference was no longer statistically significant.


CONCLUSIONS
Selective laser trabeculoplasty significantly reduces intraocular pressure in patients already on medical therapy. A sustained influence of prostaglandin therapy on the efficacy of selective laser trabeculoplasty was not found.
Triemli Hospital Zurich, Eye Clinic, Zurich, Switzerland (Institution Chairman: Matthias Becker).
C
C
Hirn
Department of Ophthalmology, UniversityHospital Zurich, Zurich, Switzerland (Institution Chairman: Klara Landau).
S
S
Zehnder
Department of Ophthalmology, UniversityHospital Zurich, Zurich, Switzerland (Institution Chairman: Klara Landau).
G
G
Bauer
Department of Ophthalmology, UniversityHospital Zurich, Zurich, Switzerland (Institution Chairman: Klara Landau).
G P
GP
Jaggi
Department of Ophthalmology, UniversityHospital Zurich, Zurich, Switzerland (Institution Chairman: Klara Landau).
M
M
Töteberg-Harms
Department of Ophthalmology, UniversityHospital Zurich, Zurich, Switzerland (Institution Chairman: Klara Landau).
S A
SA
Zweifel
Department of Ophthalmology, UniversityHospital Zurich, Zurich, Switzerland (Institution Chairman: Klara Landau).
D J
DJ
Lindegger
Department of Ophthalmology, UniversityHospital Zurich, Zurich, Switzerland (Institution Chairman: Klara Landau).
J
J
Funk
D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D053685:Laser Therapy / Q000379:methods*; D008137:Longitudinal Studies; D008297:Male; D011453:Prostaglandins / Q000009:adverse effects*; D012189:Retrospective Studies; D014130:Trabeculectomy / Q000379:methods*; D016896:Treatment Outcome
D011453:Prostaglandins