Effects of omega-3 polyunsaturated Fatty acids on heart function and oxidative stress biomarkers in pediatric patients with dilated cardiomyopathy.
OBJECTIVE
Dilated cardiomyopathy is the most prevalent type of cardiomyopathy in children, which results in congestive heart failure and causes significant morbidity and mortality. This study, aims to investigate the effect of supplementation with omega-3 polyunsaturated fatty acids (n-3 PUFA) on heart function and oxidative stress biomarkers in these patients.


METHODS
The present research was a case-control study on pediatric patients with dilated cardiomyopathy, who received n-3 PUFA and anti-failure therapy for 6 months (group 1, n = 6), or anti-failure therapy alone for 6 months (group 2, n = 6), as well as age matched normal individuals (group 3, n = 6), and evaluated the cardiac function and biomarkers of oxidative stress.


RESULTS
Echocardiographic parameters, such as left ventricular ejection fraction, shortening fraction, tissue Doppler Ea and Aa waves of lateral annulus of tricuspid valve, and Ea and S wave of septum, were significantly improved in group 1 after n-3 PUFA compared to pre- treatment status, while they were not changed after treatment in group 2. Antioxidant enzymes, including catalase and glutathione peroxidase activities in erythrocytes were slightly decreased, while plasma 8-iso-prostaglandin F2α concentrations were somewhat increased in group 1 compared to groups 2 and 3, however these changes were not statistically significant. Total antioxidant capacity of plasma was similar in all 3 groups.


CONCLUSIONS
The results indicate that some echocardiographic parameters were significantly improved in patients receiving omega-3 fish oil. However, omega-3 had no significant effect on oxidative stress biomarkers.
Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Omidreza
O
Firuzi
Division of Pediatric Cardiology, Department of pediatrics, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Nader
N
Shakibazad
Division of Pediatric Cardiology, Department of pediatrics, Shiraz University of Medical Sciences, Shiraz, IR Iran ; Cardiovascular Research Center, Shiraz University of Medical Science, Shiraz, IR Iran.
Hamid
H
Amoozgar
Division of Pediatric Cardiology, Department of pediatrics, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Mohammad
M
Borzoee
Division of Pediatric Cardiology, Department of pediatrics, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Saeed
S
Abtahi
Division of Pediatric Cardiology, Department of pediatrics, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Gholamhossein
G
Ajami
Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Pegah
P
Ardi
Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Ramin
R
Miri
Dilated Cardiomyopathy; Omega-3; Polyunsaturated Fatty Acid