Morphological characterization of fullerene-androsterone conjugates.
Here we report on the self-organization characteristics in water of two diastereomer pairs of fullerene-androsterone hybrids that have the hydrophobic C60 appendage in the A and D ring of the androsterone moiety, respectively. The morphology and particle size in aqueous solution were determined by transmission electron microscopy (TEM) and dynamic light scattering (DLS), with satisfactory agreement between both techniques. In general, these fullerene derivatives are shown to organize into spherical nano-scale structures with diameters in the ranges of 10-20 and 30-50 nm, respectively.
Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de La Habana, 10400 La Habana, Cuba.
Alberto
A
Ruiz
Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de La Habana, 10400 La Habana, Cuba.
Margarita
M
Suárez
Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid 28040 Madrid, Spain.
Nazario
N
Martin
Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain ; Centre on Bioengineering, Biomaterials and Nanomedicine, PCB, 08028-Barcelona, Spain ; Department of Organic Chemistry, University of Barcelona, 08028-Barcelona, Spain ; School of Chemistry, University of KwaZulu-Natal, Durban 400l, South Africa.
Fernando
F
Albericio
Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain.
Hortensia
H
Rodríguez
androsterone; dynamic light scattering; fullerene; transmission electron microscopy