New insights into an X-traordinary viral protein.
Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.
Department of Infectious Diseases, King's College London London, UK.
Torsten
T
Schaller
Department of Infectious Diseases, King's College London London, UK.
Hélène
H
Bauby
Department of Infection, Division of Infection and Immunity, Centre for Medical Molecular Virology, University College London London, UK.
Stéphane
S
Hué
Department of Infectious Diseases, King's College London London, UK.
Michael H
MH
Malim
Department of Infectious Diseases, King's College London London, UK.
Caroline
C
Goujon
HIV-1; HIV-2; SAMHD1; SIVsmm; interferon type I; myeloid cells; restriction factor; vpx