Role of cytokine gene polymorphisms on prognosis in hepatocellular carcinoma after radical surgery resection.
This study aimed to determine whether SNPs of cytokine genes influence survival of hepatocellular carcinoma (HCC) patients after radical surgery resection. We evaluated 14 SNPs of eight cytokine genes in 263 patients treated with radical surgery resection of HCC. Categorical variables were compared by the χ(2) test and Fisher's exact test. The Kaplan-Meier methods with log-rank test and Cox regression models were used to compare survival of resected HCC patients according to the genotype. Among the 14 studied SNPs of cytokine genes, only the TNF-α-863 (CA+CC) genotypes were revealed to be significant independent predictors of prolonged overall survival (OS) after HCC radical surgery resection (HR: 0.586, 95% CI: 0.355-0.968), considering for other clinical factors in a Cox proportional hazard model. Meanwhile, no significant association was found between the 14 SNPs and relapse-free survival (RFS) of resected HCC patients. In addition, combination analysis with the Th1 cytokine (IFN-γ, IL-2, IL-12B, TGF-β1) or Th2 cytokine (IL-6, IL-10) genetic polymorphisms by the Kaplan-Meier method and Cox multivariate analysis did not reveal any significant association between OS and RFS of resected HCC patients.
GuangXi Center for Disease Prevention and Control, Nanning, Guangxi, China.
Dongxiang
D
Pan
Department of Epidemiology and Health Statistics, Guangxi Medical University, Nanning, Guangxi, China.
Xiaoyun
X
Zeng
Department of Epidemiology and Health Statistics, Guilin Medical University, Guilin, Guangxi, China.
Hongping
H
Yu
Guangxizhuangzuzizhiqujiangbinyiyuan, Nanning, Guangxi, China.
Yan
Y
Yang
Department of Epidemiology and Health Statistics, Guilin Medical University, Guilin, Guangxi, China.
Chunhua
C
Bei
Kunming Medical College, Kunming, Yunnan, China.
Hua
H
Bai
Department of Epidemiology and Health Statistics, Guangxi Medical University, Nanning, Guangxi, China. Electronic address: xqqiu9999@sina.com.
Xiaoqiang
X
Qiu
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D016009:Chi-Square Distribution; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics; D053762:Interleukin-12 Subunit p40 / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D053773:Transforming Growth Factor beta1 / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
C500879:IL12B protein, human; D053762:Interleukin-12 Subunit p40; D007376:Interleukin-2; D015850:Interleukin-6; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma
Cytokine gene; Hepatocellular carcinoma; Polymorphisms; Survival