Lambda light chain myeloma presenting as nodular hepatic lesion: a clinical rarity.
We report a case of a 63-year-old lady presenting with pain in the right hypochondrium, jaundice, anorexia, and firm tender hepatomegaly with remarkably high serum alkaline phosphatase. Abdominal ultrasonography revealed a hypoechoic solid space-occupying lesion in right lobe of liver which was cytologically diagnosed as hepatic plasmacytoma. Serum and urine immunofixation electrophoresis, serum free light chain ratio, and bone marrow examination further confirmed the presence of lambda light chain multiple myeloma in the background. The patient achieved complete remission after four cycles of induction therapy with thalidomide and dexamethasone protocol and consolidated with further four cycles of the same regimen.
Santanu
S
Pal
Department of Radiotherapy, Medical College and Hospitals, Kolkata, India.
Bitoti
B
Chattopadhyay
Atri
A
Chatterjee
Biswamit
B
Bhattacharya
D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D005260:Female; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D010954:Plasmacytoma / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D012074:Remission Induction; D012886:Skull / Q000473:pathology; D014057:Tomography, X-Ray Computed
D007146:Immunoglobulin lambda-Chains