Application of genomic principles to pharmacotherapy of cancer.
OBJECTIVE
To teach first-year (P1) pharmacy students to apply the principles of pharmacogenomics underlying clinical pharmacotherapeutics to cancer patients.


METHODS
Using polymerase chain reaction (PCR) and high-resolution melting analysis of deoxyribonucleic acid (DNA) from colorectal cancer cell lines to determine the presence of somatic mutations for an oncogenic marker, students formulated the proper course of treatment for a patient with similar tumor genomics.


RESULTS
In a postintervention survey, students highly rated the effectiveness of the laboratory session for learning pharmacogenomics, and subsequent examination scores reflected retention of principles and understanding of clinical application.


CONCLUSIONS
The pharmacogenomic laboratory exercise prepared students to understand how genetic markers give clinical insight into the appropriate application of drugs in oncology pharmacotherapy. Further, the session inspired their interest in learning more about pharmacogenomics and their professional roles in personalized medicine.
School of Pharmacy, Presbyterian College, Clinton, South Carolina.
Christopher L
CL
Farrell
School of Pharmacy, Presbyterian College, Clinton, South Carolina.
Nancy G
NG
Pedigo
School of Pharmacy, Presbyterian College, Clinton, South Carolina.
Amy R
AR
Messersmith
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics*; D032882:Comprehension; D003479:Curriculum; D004252:DNA Mutational Analysis; D004512:Education, Pharmacy / Q000379:methods*; D005260:Female; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000193:education*; D006801:Humans; D007858:Learning; D008297:Male; D008495:Medical Oncology / Q000193:education*; D008875:Middle Aged; D009154:Mutation; D010597:Pharmacogenetics / Q000193:education*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D057285:Precision Medicine; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D013663:Teaching / Q000379:methods*
D000970:Antineoplastic Agents; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
active learning; cancer; genomics; oncology; pharmacogenomics; pharmacotherapy