[In vitro effect of psychotropic drugs on the activity of leukocyte elastase].
OBJECTIVE
To investigate the effect of the neuroleptic aminazine (chlorpromazine) and the antidepressant melipramine on the activity of leukocyte elastase (LE).


METHODS
The LE activity was measured on a spectrophotometer. Different doses of aminazine and melipramine in terms of therapeutic doses were added to the pooled blood serum sampled from 7 healthy people.


RESULTS
Aminazine and melipramine inhibited the LE activity.


CONCLUSIONS
The dose-dependent inhibiting effect of aminazine and melipramine was shown.
L V
LV
Androsova
A A
AA
Shmakova
D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007099:Imipramine / Q000494:pharmacology*; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors* / Q000097:blood; D011619:Psychotropic Drugs / Q000494:pharmacology*
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D004791:Enzyme Inhibitors; D011619:Psychotropic Drugs; D019272:Leukocyte Elastase; D007099:Imipramine; D002746:Chlorpromazine