Protective effect of some amino acids synthesized derivatives and their chelates on Escherichia coli under X-ray irradiation.
The protective effects of novel synthesized derivatives of some amino acids--nicotinyl-L-tyrosinate and nicotinyl-L-tryptophanate schiff bases and their Cu(II) and Mn(II) chelates on growth, survival and membrane-associated ATPase activity of E. coli under X-ray irradiation were investigated. The specific growth rate and survival of E. coli were decreased at 10, 20 and 30 Gy doses. However, as 30 Gy was found to be the most effective irradiation dose, it was chosen for studying the radio-protective properties of different compounds. These compounds could increase the bacterial cell protection against X-ray irradiation in concentration-dependent manner. They had a role in stimulation of synthesis or regulation of activity of metal-dependent enzymes, required for reversing the X-ray irradiation damage. The study may prove useful for further estimation of the effectiveness of different compounds as radio-protectors on bacteria and other cells, especially mammalian cells under X-ray irradiation.
G
G
Kirakosyan
H
H
Torgomyan
M
M
Malakyan
S
S
Bajinyan
A
A
Trchounian
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D002614:Chelating Agents / Q000737:chemistry*; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development / Q000528:radiation effects*; D050296:Microbial Viability / Q000187:drug effects; D014965:X-Rays / Q000009:adverse effects
D000596:Amino Acids; D002614:Chelating Agents; D000251:Adenosine Triphosphatases