Integrating non-coding RNAs in JAK-STAT regulatory networks.
Being a well-characterized pathway, JAK-STAT signaling serves as a valuable paradigm for studying the architecture of gene regulatory networks. The discovery of untranslated or non-coding RNAs, namely microRNAs and long non-coding RNAs, provides an opportunity to elucidate their roles in such networks. In principle, these regulatory RNAs can act as downstream effectors of the JAK-STAT pathway and/or affect signaling by regulating the expression of JAK-STAT components. Examples of interactions between signaling pathways and non-coding RNAs have already emerged in basic cell biology and human diseases such as cancer, and can potentially guide the identification of novel biomarkers or drug targets for medicine.
Integrative Immunobiology Unit; Laboratory of Immunology; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, MD USA ; Wellcome Trust Sanger Institute; Genome Campus; Hinxton, UK.
Steven
S
Witte
Integrative Immunobiology Unit; Laboratory of Immunology; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, MD USA.
Stefan A
SA
Muljo
cellular differentiation; epigenetics; gene expression program; long non-coding RNA; microRNA; posttranscriptional regulation