Disposable copper-based electrochemical sensor for anodic stripping voltammetry.
In this work, we report the first copper-based point-of-care sensor for electrochemical measurements demonstrated by zinc determination in blood serum. Heavy metals require careful monitoring, yet current methods are too complex for a point-of-care system. Electrochemistry offers a simple approach to metal detection on the microscale, but traditional carbon, gold (Au), or platinum (Pt) electrodes are difficult or expensive to microfabricate, preventing widespread use. Our sensor features a new low-cost electrode material, copper, which offers simple fabrication and compatibility with microfabrication and PCB processing, while maintaining competitive performance in electrochemical detection. Anodic stripping voltammetry of zinc using our new copper-based sensors exhibited a 140 nM (9.0 ppb) limit of detection (calculated) and sensitivity greater than 1 μA/μM in the acetate buffer. The sensor was also able to determine zinc in a bovine serum extract, and the results were verified with independent sensor measurements. These results demonstrate the advantageous qualities of this lab-on-a-chip electrochemical sensor for clinical applications, which include a small sample volume (μL scale), reduced cost, short response time, and high accuracy at low concentrations of analyte.
BioMicroSystems Lab, Department of Electrical Engineering and Computing Systems, University of Cincinnati , Cincinnati, Ohio 45221-0030, United States.
Xing
X
Pei
Wenjing
W
Kang
Wei
W
Yue
Adam
A
Bange
William R
WR
Heineman
Ian
I
Papautsky
D000818:Animals; D002417:Cattle; D003300:Copper / Q000737:chemistry*; D004563:Electrochemistry / Q000295:instrumentation*; D004566:Electrodes; D056656:Lab-On-A-Chip Devices; D055616:Microtechnology / Q000379:methods*; D019095:Point-of-Care Systems; D012710:Serum Albumin, Bovine / Q000737:chemistry; D015032:Zinc / Q000097:blood
D012710:Serum Albumin, Bovine; D003300:Copper; D015032:Zinc