Age-specific prevalence of serrated lesions and their subtypes by screening colonoscopy: a retrospective study.
BACKGROUND
Serrated lesions of the colorectum as categorized by pathology include hyperplastic polyps, sessile serrated adenomas without dysplasia, and traditional serrated adenomas with dysplasia. The aim of this study was to investigate the prevalence of various subtypes of serrated lesions by age.


METHODS
In this study, 28,544 consecutive asymptomatic patients (aged 22-88 years) were evaluated during health check-ups involving colonoscopies performed by gastroenterologists at a single institution from 2005 to 2012.


RESULTS
The adenoma detection rate during colonoscopies for patients aged ≥50 years was 31.8% (25.0-35.8%). The serrated lesion detection rate for patients aged ≥50 years was 15.3% (10.5-19.6%). Serrated lesions were detected in 15.1% of all patients with subtype prevalences of 14.7% for hyperplastic polyps, 0.5% for sessile serrated adenomas, and 0.1% for traditional serrated adenomas. The prevalence of conventional adenomas increased sharply with age (5.0% in patients aged 20-29 years, 10.9% in those aged 30-39 years, 21.8% in those aged 40-49 years, 29.5% in those aged 50-59 years, 36.9% in those aged 60-69 years, and 40.7% in those aged ≥70 years) (trend P = 0.027). In contrast, the prevalence of serrated lesions increased only slightly with age (10.0% in patients aged 20-29 years, 11.8% in those aged 30-39 years, 14.8% in those aged 40-49 years, 15.3% in those aged 50-59 years, 16.8% in those aged 60-69 years, and 16.4% in those aged ≥70 years) (trend P = 0.036).


CONCLUSIONS
The screening colonoscopy detection rate of serrated lesions, including sessile serrated adenomas and traditional serrated adenomas, appears to be relatively high among young patients aged <50 years.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea. cecilup@naver.com.
Hyun Young
HY
Kim
Seon Mie
SM
Kim
Ji-Hyun
JH
Seo
Eun-Ha
EH
Park
Nayoung
N
Kim
Dong Ho
DH
Lee
D000236:Adenoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000453:epidemiology; D003111:Colonic Polyps / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D055815:Young Adult