Preparation and drug release properties of chitosan/organomodified palygorskite microspheres.
The novel composite microspheres, based on the hybridization of chitosan (CS) and organomodified palygorskite (OPAL), were prepared by emulsion cross-linking technique and applied as a drug carrier. Palygorskite, a kind of natural one-dimensional clay, was modified with hexadecyl betaine (BS-16) to improve the compatibility and affinity with chitosan matrix, and worked as a perfect micron-filler to enhance drug encapsulation and retard drug migration. The structure of the microspheres was characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and X-ray diffraction (XRD) techniques. The swelling behavior of the microspheres and the effect of the amount of OPAL and BS-16 on the properties of the drug loading and releasing have been investigated. Compared to the pure chitosan microspheres (CM), the composite one with 20wt% OPAL modified by 20mmol/100g BS-16 possessed the higher encapsulation efficiency and the slower and continuous cumulative release for diclofenac sodium (DS) in phosphate buffer solution (pH 6.8). The study of drug release kinetics in vitro found that the drug release mechanism of the microspheres changed from the simple diffusion-control to diffusion and dissolution-control as the OPAL content in matrix increased from 0 to 20wt%.
Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, School of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Huaian 223003, China. Electronic address: wujie1760@l26.com.
Jie
J
Wu
Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, School of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Huaian 223003, China.
Shijie
S
Ding
Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, School of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Huaian 223003, China.
Jing
J
Chen
Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, School of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Huaian 223003, China.
Suqin
S
Zhou
Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, School of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Huaian 223003, China.
Hongyan
H
Ding
D048271:Chitosan / Q000737:chemistry*; D004008:Diclofenac; D065546:Drug Liberation; D007700:Kinetics; D017616:Magnesium Compounds / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009930:Organic Chemicals / Q000737:chemistry*; D010316:Particle Size; D017655:Silicon Compounds / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents / Q000737:chemistry; D014783:Viscosity; D014961:X-Ray Diffraction
D017616:Magnesium Compounds; D009930:Organic Chemicals; D017655:Silicon Compounds; D013501:Surface-Active Agents; D004008:Diclofenac; D048271:Chitosan; C026325:attapulgite
Chitosan; Composite microspheres; Drug release; Organomodified; Palygorskite