In vivo imaging of middle-ear and inner-ear microstructures of a mouse guided by SD-OCT combined with a surgical microscope.
We developed an augmented-reality system that combines optical coherence tomography (OCT) with a surgical microscope. By sharing the common optical path in the microscope and OCT, we could simultaneously acquire OCT and microscope views. The system was tested to identify the middle-ear and inner-ear microstructures of a mouse. Considering the probability of clinical application including otorhinolaryngology, diseases such as middle-ear effusion were visualized using in vivo mouse and OCT images simultaneously acquired through the eyepiece of the surgical microscope during surgical manipulation using the proposed system. This system is expected to realize a new practical area of OCT application.
Nam Hyun
NH
Cho
Jeong Hun
JH
Jang
Woonggyu
W
Jung
Jeehyun
J
Kim
D000818:Animals; D003952:Diagnostic Imaging; D004195:Disease Models, Animal; D004427:Ear Diseases / Q000175:diagnosis* / Q000601:surgery; D007758:Ear, Inner / Q000473:pathology* / Q000601:surgery; D004432:Ear, Middle / Q000473:pathology* / Q000601:surgery; D007432:Intraoperative Period; D051379:Mice; D008853:Microscopy / Q000295:instrumentation*; D013506:Otologic Surgical Procedures; D041623:Tomography, Optical Coherence / Q000295:instrumentation*