Prediagnostic telomere length and risk of B-cell lymphoma-Results from the EPIC cohort study.
Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the ratio of telomere repeat copy number to single gene copy number) was measured in mononuclear cell DNA of prediagnostic peripheral blood samples of 464 lymphoma cases and 464 matched controls (median time between blood collection and diagnosis, 4.6 years). Conditional logistic regression was used to analyze the association between TL and the risk of developing lymphoma and histologic subtypes. TL was significantly longer in cases compared to controls (p = 0.01). Multivariable models showed a significantly increased risk of BCL [odds ratio (OR) = 1.66, 1.80 and 3.20 for quartiles 2-4, respectively, p-trend = 0.001], diffuse large B-cell lymphoma (DLBCL) (OR = 1.20, 2.48 and 2.36 for quartiles 2-4, respectively, p-trend = 0.03) and follicular lymphoma (FL) (OR = 1.39, 1.90 and 2.69 for quartiles 2-4, respectively, p-trend = 0.02) with increasing TL. This study suggests an association between longer leucocyte TL and increased risk of BCL which was most pronounced for DLBCL and FL.
Institute for Risk Assessment Sciences (IRAS), Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands; Zanjan University of Medical Sciences, Zanjan, Iran.
Fatemeh Saberi
FS
Hosnijeh
Giuseppe
G
Matullo
Alessia
A
Russo
Simonetta
S
Guarrera
Federica
F
Modica
Alexandra
A
Nieters
Kim
K
Overvad
Per
P
Guldberg
Anne
A
Tjønneland
Federico
F
Canzian
Heiner
H
Boeing
Krasimira
K
Aleksandrova
Antonia
A
Trichopoulou
Pagona
P
Lagiou
Dimitrios
D
Trichopoulos
Giovanna
G
Tagliabue
Rosario
R
Tumino
Salvatore
S
Panico
Domenico
D
Palli
Karina Standahl
KS
Olsen
Elisabete
E
Weiderpass
Miren
M
Dorronsoro
Eva
E
Ardanaz
Maria-Dolores
MD
Chirlaque
María-José
MJ
Sánchez
J Ramón
JR
Quirós
Adoración
A
Venceslá
Beatrice
B
Melin
Ann Sofie
AS
Johansson
Peter
P
Nilsson
Signe
S
Borgquist
Petra H
PH
Peeters
N Charlotte
NC
Onland-Moret
H B
HB
Bueno-de-Mesquita
Ruth C
RC
Travis
Kay-Tee
KT
Khaw
Nick
N
Wareham
Paul
P
Brennan
Pietro
P
Ferrari
Marc J
MJ
Gunter
Paolo
P
Vineis
Roel
R
Vermeulen
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004247:DNA / Q000032:analysis; D005060:Europe; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D015994:Incidence; D007962:Leukocytes / Q000166:cytology; D016393:Lymphoma, B-Cell / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D016615:Telomere / Q000648:ultrastructure*
D004247:DNA
NHL; lymphoma; prospective study; telomeres