[Determination of R(-)- isomer in repaglinide tablets by capillary electrophoresis].
To develop a capillary electrophoresis system for enantiomeric impurity test of repaglinide.



An uncoated fused silica capillary (50 μm×50 cm, with an effective length of 41 cm) was used. The running buffer was composed of 30 mmol/L NaH2PO4 and 5 mg/ml carboxymethyl-β-cyclodextrin(pH 3.5).



Linear range was 2.00-80.00 μg/ml (correlation coefficient was 0.9993). The average recovery rate was 92.5% to 105.0%.



The method is simple, accurate and sensitive and it can be used for determination of enantiomeric impurities in repaglinide tablet.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xiao-wei
XW
Yuan
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Jia-yi
JY
Sun
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Shi-zhuo
SZ
Wang
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xing-jie
XJ
Guo
D002219:Carbamates / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*; D010880:Piperidines / Q000032:analysis*; D013237:Stereoisomerism; D013607:Tablets
D002219:Carbamates; D010880:Piperidines; D013607:Tablets; C072379:repaglinide