Neutrophil energetics and oxygen sensing.
In this issue of Blood, Jun et al, through the study of neutrophils deficient in the glucose-6-phosphate transporter, describe a novel role for the peroxisome proliferator-activated receptor-γ (PPARG) pathway in the regulation of key neutrophil functions and link this to concomitant hypoxia-inducible factor (HIF) 1α stabilization.
UNIVERSITY OF SHEFFIELD.
Sarah R
SR
Walmsley
Moira K B
MK
Whyte
D005953:Glycogen Storage Disease Type I / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D009504:Neutrophils / Q000378:metabolism*