Alteration of T-cell subpopulations and lipid peroxidation in the blood of patients with vulvar non-neoplastic epithelial disorder.
OBJECTIVE
To determine the relationship between vulvar non-neoplastic epithelial disorder and thymus-dependent lymphyocyte levels and lipid peroxidation.


METHODS
the authors measured the levels of CD3+, CD4+, CD8+, CD16+ T cell, and the concentration of superoxide dismutase (SOD) and malondialdehyde (MDA) in the blood of 62 patients with vulvar non-neoplastic epithelial disorder. A control group consisted of 30 normal women from the present hospitals.


RESULTS
The level of CD4+/CD8+ T-lymphocytes and SOD in the blood of the patients with vulvar non-neoplastic epithelial disorder was significantly lower than that in control subjects, but the level of MDA was higher as compared with normal women.


CONCLUSIONS
There is increased immune activation and lipid peroxidation in patients with vulvar non-neoplastic epithelial disorder, which could contribute to destruction of vulvar tissue.
G T
GT
Li
S Z
SZ
Guo
Y J
YJ
Liu
B
B
Yang
D000328:Adult; D017252:CD3 Complex / Q000097:blood; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006965:Hyperplasia; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D017452:Receptors, IgG / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D016176:T-Lymphocyte Subsets; D014844:Vulva / Q000473:pathology*; D007724:Vulvar Lichen Sclerosus / Q000097:blood*
D017252:CD3 Complex; D017452:Receptors, IgG; D008315:Malondialdehyde; D013482:Superoxide Dismutase