Gene polymorphisms associated with susceptibility to coronary artery disease in Han Chinese people.
This study investigated 5 single nucleotide polymorphism (SNP) haplotypes in susceptibility genes for coronary artery disease (CAD) and the putative involvement of these SNPs in CAD in the Chi-nese Han population. From March 2008 to June 2009, we selected 119 CAD patients and 115 subjects not related to the CAD of Chinese Han or-igin as controls. The SNP genotypes were performed by multiplex SNaP-shot technology. The HNRPUL1 gene rs11881940T and GATA2 gene rs3803T loci were highly correlated with CAD (P < 0.05). rs10757278G increased the risk of CAD in patients indicated by an odds ratio (OR) = 1.242 [95% confidence interval (CI) = 1.04-1.49]; rs11881940T and rs3803T were protective factors for CAD with ORs = 0.767 (95%CI = 0.61-0.97) and 0.53 (95%CI = 0.40-0.72), respectively. Analysis of the rs10757278, rs11881940 and rs3803 loci showed that haplotypes ATC (OR = 4.26; 95%CI = 2.85-6.40, P < 0.01), GAC (OR = 1.50; 95%CI = 1.25-1.81, P < 0.01) and GAT (OR = 1.53; 95%CI = 1.12-2.09, P < 0.01) were CAD risk factors, whereas GTC was protective (OR = 0.48; 95%CI = 0.32-0.72, P < 0.01). ATC and glucose were positively correlated (OR = 1.91; 95%CI = 1.01-3.61, P < 0.05). GAT was a risk factor for hyper-tension (OR = 2.86; 95%CI = 1.40-5.83, P < 0.01). In conclusion, poly-morphisms and haplotype analysis of susceptibility genes for CAD can improve predicting this disease and will enable early diagnosis of CAD.
Department of Laboratory Medicine, Sun Yat-sen Cardiovascular Hospital, Shenzhen, Guangdong, China.
Y H
YH
Liu
Department of Laboratory Medicine, Sun Yat-sen Cardiovascular Hospital, Shenzhen, Guangdong, China yiwenzhou21@aliyun.com.
Y W
YW
Zhou
Department of Cardiac Surgery, Sun Yat-sen Cardiovascular Hospital, Shenzhen, Guangdong, China.
J A
JA
Yang
Department of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Z G
ZG
Tu
Department of Cardiac Surgery, Sun Yat-sen Cardiovascular Hospital, Shenzhen, Guangdong, China.
S Y
SY
Ji
Department of Cardiac Surgery, Sun Yat-sen Cardiovascular Hospital, Shenzhen, Guangdong, China.
Z Y
ZY
Huang
Department of Laboratory Medicine, Sun Yat-sen Cardiovascular Hospital, Shenzhen, Guangdong, China.
Z J
ZJ
Zhou
D000368:Aged; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D042241:Early Diagnosis; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*
D011506:Proteins