Amelioration of doxorubicin induced cardio-and hepato-toxicity by carotenoids.
OBJECTIVE
The aim of this study is to explore the ability of the carotenoids (CARs) to offer protection against acute cardiotoxicity and hepatotoxicity induced by doxorubicin (DOX) (25 mg/kg) in tumor bearing Swiss albino mice.


METHODS
Tumor bearing Swiss albino mice administered with DOX (25 mg/kg, i.p) and two doses of CARs (50 and 100 μg/kg). 24 h after administration of the drugs, histopathological evaluation of tumor, liver and heart tissues carried out. Furthermore, various antioxidant parameters in these tissues were investigated. Serum marker enzymes for tissue injury were examined.


RESULTS
Administration of CARs prevented the depletion of antioxidants in the heart and liver, thereby protecting the tissue damage and release of marker enzymes. However, similar antioxidant depletion was not observed in the tumor tissue. CARs prevented DOX induced variation in tissue architecture in heart and liver tissues. However, CARs did not influence DOX induced alterations in the tumor.


CONCLUSIONS
Administration of CARs could prevent DOX induced acute toxicity to heart and liver.
R
R
Indu
T S
TS
Azhar
Arathy
A
Nair
Department of Radiation Biology, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, Kerala, India.
Cherupally Krishnan Krishnan
CK
Nair
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D002338:Carotenoids / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy; D018384:Oxidative Stress / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D015415:Biomarkers; D002338:Carotenoids; D004317:Doxorubicin