A 3'UTR polymorphism of IL-6R is associated with Chinese pediatric tuberculosis.
BACKGROUND
IL-6 is a proinflammatory cytokine that plays a critical role in host defense against tuberculosis (TB). Genetic polymorphisms of IL-6 and its receptor IL-6R had been discussed in adult TB recently. However, their role in pediatric TB is still unclear. Due to the obvious differences in TB pathophysiology in children, which may also reflect differences in genetic background, further association studies in pediatric populations are needed.


METHODS
A case-control study was carried out in a Chinese pediatric population including 353 TB patients and 400 healthy controls. Tag-SNPs of IL-6 and IL-6R genes were selected by Haploview software, genotyped using MassArray, and analyzed statistically.


RESULTS
One polymorphism, rs2229238, in the 3'UTR region of IL-6R was observed to be associated with increased resistance to TB (adjusted P = 0.03). The rs2229238 T allele contributed to a reduced risk to TB in recessive heritable model (OR, 0.53; 95% CI, 0.35-0.78).


CONCLUSIONS
By tag-SNP genotyping based case-control study, we identified a genetic polymorphism in the IL-6R 3'UTR that regulates host resistance to pediatric TB in a Chinese population.
Key Laboratory of Major Diseases in Children and National, Key Discipline of Pediatrics, (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, No. 56 Nan-li-shi Road, Beijing 100045, China.
Chen
C
Shen
Key Laboratory of Major Diseases in Children and National, Key Discipline of Pediatrics, (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, No. 56 Nan-li-shi Road, Beijing 100045, China.
Hui
H
Qi
Key Laboratory of Major Diseases in Children and National, Key Discipline of Pediatrics, (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, No. 56 Nan-li-shi Road, Beijing 100045, China.
Lin
L
Sun
Key Laboratory of Major Diseases in Children and National, Key Discipline of Pediatrics, (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, No. 56 Nan-li-shi Road, Beijing 100045, China.
Jing
J
Xiao
Key Laboratory of Major Diseases in Children and National, Key Discipline of Pediatrics, (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, No. 56 Nan-li-shi Road, Beijing 100045, China.
Qing-qin
QQ
Yin
Key Laboratory of Major Diseases in Children and National, Key Discipline of Pediatrics, (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, No. 56 Nan-li-shi Road, Beijing 100045, China.
Wei-wei
WW
Jiao
Key Laboratory of Major Diseases in Children and National, Key Discipline of Pediatrics, (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, No. 56 Nan-li-shi Road, Beijing 100045, China.
Xi-rong
XR
Wu
Key Laboratory of Major Diseases in Children and National, Key Discipline of Pediatrics, (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, No. 56 Nan-li-shi Road, Beijing 100045, China.
Jian-ling
JL
Tian
Key Laboratory of Major Diseases in Children and National, Key Discipline of Pediatrics, (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, No. 56 Nan-li-shi Road, Beijing 100045, China.
Rui
R
Han
Key Laboratory of Major Diseases in Children and National, Key Discipline of Pediatrics, (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, No. 56 Nan-li-shi Road, Beijing 100045, China.
A-dong
AD
Shen
D020413:3' Untranslated Regions; D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D007223:Infant; D008297:Male; D020641:Polymorphism, Single Nucleotide; D019947:Receptors, Interleukin-6 / Q000235:genetics* / Q000276:immunology; D014376:Tuberculosis / Q000235:genetics* / Q000276:immunology
D020413:3' Untranslated Regions; C508603:IL6R protein, human; D019947:Receptors, Interleukin-6