Two cases of successful pregnancies after hysteroscopic removal of endometrioid adenocarcinoma grade I, stage IA, in young women with Lynch syndrome.
We present two cases of endometrioid adenocarcinoma grade I, FIGO IA (staging according to the International Federation of Gynecology and Obstetrics) in young women, diagnosed within endometrial polyps. Both patients underwent repeated hysteroscopies and multiple biopsies after initial treatment to medroxyprogesterone one 400 mg daily or the insertion of IUD-LND (intrauterine device-levonorgestrel) for three months. In both of them, all histological samples were negative. Both of them decided that they would try to conceive. The first patient conceived spontaneously and the second patient after IVF (in vitro fertilisation) treatment. They both gave birth to full-term infants. Hysterectomy was recommended to both of our patients, and was carried out. Both of the patients fulfilled both Amsterdam II and revised Bethesda criteria for hereditary non-polyposis colorectal cancer (HNPCC).
Clinic of Gynecology and Obstetrics, University Hospital "Sv. Duh", Zagreb, Croatia.
Ingrid
I
Marton
Clinic of Gynecology and Obstetrics, Clinical Medical Centre "SM", Zagreb, Croatia.
Hrvojka Soljacic
HS
Vranes
Polyclinic of Gynecology and Obstetrics "Cito", Split, Croatia.
Vladimir
V
Sparac
Department of Gynecology and Obstetrics, General Hospital Zabok, Zabok, Croatia.
Igor
I
Maricic
Clinic of Gynecology and Obstetrics, Clinical Medical Centre "SM", Zagreb, Croatia.
Krunoslav
K
Kuna
Clinic of Gynecology and Obstetrics, Clinical Medical Centre "SM", Zagreb, Croatia.
Miroslav
M
Kopjar
Endometrial cancer; Lynch syndrome; hysteroscopy; reproduction