Bioactivity of a family of chiral nonracemic aminobenzylnaphthols towards Candida albicans.
Chiral nonracemic aminobenzylnaphthols were obtained by a Betti multi-component reaction between 2-naphthol, aryl aldehydes and enantiopure arylethylamine. Moreover, some new aminobenzylnaphthols were synthesized by a similar reaction between 2-naphthol, aryl aldehydes and prolinol. These aminobenzylnaphthols, synthesized from different components and thus having different structural features, were tested as anti-yeast agents inhibiting Candida albicans. The effect towards the test strain was studied with a microdilution approach and three different concentrations (150, 300 and 450 µg/mL) were tested. The best results were found for the aminobenzylnaphthols obtained from 1-naphthylethylamine and from natural prolinol. The use of the two-way ANOVA highlighted the better performances of the prolinol derivative among the differently structured aminobenzylnaphthols that were screened. The activity towards C. albicans of this prolinol derivative resulted to be interesting and could represent a promising alternative to overcome the problem of the strains resistant to the traditional antifungals.
Department of Chemistry, University of Bari, Via Orabona 4, 70125 Bari, Italy. maria.capozzi@uniba.it.
Maria Annunziata M
MA
Capozzi
CNR-ICCOM, at the Department of Chemistry, University of Bari, Via Orabona 4, 70125 Bari, Italy. cardellicchio@ba.iccom.cnr.it.
Cosimo
C
Cardellicchio
Department of Chemistry, University of Bari, Via Orabona 4, 70125 Bari, Italy. angelamagaletti@gmail.com.
Angela
A
Magaletti
Department of the Science of Agriculture, Food and Environment, University of Foggia, Via Napoli 25, 71122 Foggia, Italy. antonio.bevilacqua@unifg.it.
Antonio
A
Bevilacqua
Department of the Science of Agriculture, Food and Environment, University of Foggia, Via Napoli 25, 71122 Foggia, Italy. marianne.perricone@unifg.it.
Marianne
M
Perricone
Department of the Science of Agriculture, Food and Environment, University of Foggia, Via Napoli 25, 71122 Foggia, Italy. mariarosaria.corbo@unifg.it.
Maria Rosaria
MR
Corbo
D062365:Aminobenzoates / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D005021:Ethylamines / Q000737:chemistry; D015725:Fluconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009284:Naphthols / Q000138:chemical synthesis / Q000494:pharmacology*; D011759:Pyrrolidines / Q000737:chemistry; D013329:Structure-Activity Relationship
D062365:Aminobenzoates; D000935:Antifungal Agents; D005021:Ethylamines; D009284:Naphthols; D011759:Pyrrolidines; C010509:prolinol; D015725:Fluconazole