Small vessel disease and the resting functional architecture of the brain.
Small vessel disease (SVD) is linked to cognitive impairment and dementia, yet little is known regarding functional activation in patients with SVD. Resting fMRI recordings suggest reduced connectivity in prefrontal, parietal and cingulate nodes and reciprocally increased connectivity in cerebellum, alterations which predicted neuropsychological test performance. Together with diffusion tensor tensor imaging studies, these data support of a model of disrupted connectivity as a systems-level approach to the cognitive disturbances seen in SVD.
1] Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [2] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [3] Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [4] Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Robert D
RD
Stevens
1] Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [2] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yousef
Y
Hannawi
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Haris
H
Sair
D001921:Brain / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology*; D002561:Cerebrovascular Disorders / Q000473:pathology / Q000503:physiopathology*; D003072:Cognition Disorders / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology*