No association between CCL2 gene polymorphisms and risk of inflammatory demyelinating diseases in a Korean population.
Inflammatory demyelinating disease (IDD), which includes multiple sclerosis (MS) and neuromyelitis optica (NMO), affects the central nervous system. Chemokine ligand 2 (CCL2/MCP-1) is considered an important contributor to the development or progression of IDD. However, genetic association studies of Asian populations are lacking. In this study, we investigated a possible association between CCL2 polymorphisms (rs1024611, rs28730833, and rs2857657) and a Korean population (178 IDD patients and 237 healthy controls) using multiple logistic regression models. However, we did not find any association, which was consistent with other studies in Caucasian populations. In conclusion, our results suggest that CCL2 variants may not contribute to the pathogenesis of IDD.
Department of Life Science, Sogang University, Seoul, Republic of Korea; Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Republic of Korea.
S
S
Namgoong
J S
JS
Bae
H S
HS
Cheong
J-H
JH
Kim
J Y
JY
Kim
L H
LH
Kim
H J
HJ
Kim
H D
HD
Shin
D000328:Adult; D044466:Asian People / Q000235:genetics*; D018932:Chemokine CCL2 / Q000235:genetics*; D003711:Demyelinating Diseases / Q000150:complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
C111835:CCL2 protein, human; D018932:Chemokine CCL2
CCL2; IDD; MS; NMO; association study; polymorphism