Central motor and sensory conduction in patients with hepatic myelopathy.
METHODS
Experimental neurophysiological study.


OBJECTIVE
The hepatic myelopathy (HM) is characterized by progressive weakness and spasticity of the lower extremities, while there are only a few reports of sensory impairment. However, sensory function has been poorly explored in HM. We believe that an electrophysiological assessment of dorsal columns by somatosensory evoked potentials (SEPs) and of cortico-spinal lateral tracts by motor evoked potentials (MEPs) should be of considerable value in the functional evaluation of the spinal cord involvement in patients with HM.


METHODS
Salzburg (Austria) and Merano (Italy).


METHODS
Eight patients diagnosed with HM were studied with MEPs and SEPs. Neurological examination revealed different degrees of cortico-spinal tract involvement in all patients and sensory abnormalities in three patients.


RESULTS
Central motor conduction to lower limb muscles was abnormal in all patients, while central sensory conduction was abnormal in seven out of the eight patients. Both central motor and sensory conduction to upper limbs are normal in all patients.


CONCLUSIONS
The main finding is that electrophysiological evidence of central sensory involvement is present in a very high percentage of patients with HM, and that the threshold for electrophysiological abnormalities is below that for clinical manifestations. Therefore, central sensory and motor conduction studies are sensitive methods for detecting, localizing and monitoring spinal cord damage in HM.
1] Department of Neurology, Center for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria [2] Department of Neurology, Franz Tappeiner Hospital, Merano, Italy [3] Spinal Cord Injury and Tissue Regeneration Center, Paracelsus Medical University, Salzburg, Austria.
R
R
Nardone
Department of Neurology, Franz Tappeiner Hospital, Merano, Italy.
A
A
Orioli
1] Department of Neurology, Center for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria [2] Spinal Cord Injury and Tissue Regeneration Center, Paracelsus Medical University, Salzburg, Austria.
Y
Y
Höller
Department of Neurology, Franz Tappeiner Hospital, Merano, Italy.
P
P
Lochner
Department of Neurology, Center for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria.
A
A
Kunz
Department of Neurology, Center for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria.
S
S
Golaszewski
1] Department of Neurology, Franz Tappeiner Hospital, Merano, Italy [2] Section of Clinical Neurology, Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy.
F
F
Brigo
1] Department of Neurology, Center for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria [2] Spinal Cord Injury and Tissue Regeneration Center, Paracelsus Medical University, Salzburg, Austria.
E
E
Trinka
D000328:Adult; D000368:Aged; D019054:Evoked Potentials, Motor; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology*; D035002:Lower Extremity / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology*; D009460:Neurologic Examination; D011712:Pyramidal Tracts / Q000503:physiopathology; D013118:Spinal Cord Diseases / Q000503:physiopathology*; D034941:Upper Extremity / Q000503:physiopathology