Breakthrough invasive Candida glabrata in patients on micafungin: a novel FKS gene conversion correlated with sequential elevation of MIC.
Candida glabrata strains sequentially isolated from blood developed resistance to micafungin (MICs from <0.015 to 4 μg/ml). A novel mutation identified in micafungin-resistant strains at bp 262 of FKS2 (containing a deletion of F659 [F659del]) was inserted into the homologous region in FKS1.
Kyorin University School of Medicine, Department of Respiratory Medicine, Mitaka, Tokyo, Japan sara@yd5.so-net.ne.jp.
Takeshi
T
Saraya
Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan.
Koichi
K
Tanabe
Kyorin University School of Medicine, Department of Laboratory Medicine, Mitaka, Tokyo, Japan.
Koji
K
Araki
Kyorin University School of Medicine, Department of Laboratory Medicine, Mitaka, Tokyo, Japan.
Shota
S
Yonetani
Kyorin University School of Medicine, Department of Laboratory Medicine, Mitaka, Tokyo, Japan.
Hiroshi
H
Makino
Kyorin University School of Medicine, Department of Respiratory Medicine, Mitaka, Tokyo, Japan.
Takayasu
T
Watanabe
Kyorin University School of Medicine, Department of Respiratory Medicine, Mitaka, Tokyo, Japan.
Naoki
N
Tsujimoto
Kyorin University School of Medicine, Department of Respiratory Medicine, Mitaka, Tokyo, Japan.
Saori
S
Takata
Kyorin University School of Medicine, Department of Respiratory Medicine, Mitaka, Tokyo, Japan.
Daisuke
D
Kurai
Kyorin University School of Medicine, Department of Respiratory Medicine, Mitaka, Tokyo, Japan.
Haruyuki
H
Ishii
Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan.
Yoshitsugu
Y
Miyazaki
Kyorin University School of Medicine, Department of Respiratory Medicine, Mitaka, Tokyo, Japan.
Hajime
H
Takizawa
Kyorin University School of Medicine, Department of Respiratory Medicine, Mitaka, Tokyo, Japan.
Hajime
H
Goto
D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001483:Base Sequence; D041221:Candida glabrata / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D058387:Candidemia / Q000188:drug therapy* / Q000382:microbiology*; D054714:Echinocandins / Q000494:pharmacology / Q000627:therapeutic use*; D005656:Fungal Proteins / Q000235:genetics*; D005785:Gene Conversion; D006801:Humans; D055666:Lipopeptides / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D000077551:Micafungin; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D017384:Sequence Deletion
D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D055666:Lipopeptides; D000077551:Micafungin