Expression profile of neuro-endocrine-immune network in rats with vascular endothelial dysfunction.
This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothelial dysfunction in all three models with varying degrees. However, the expression of NEI network was totally different. Interestingly, treatment with simvastatin was able to improve vascular endothelial function and restored the imbalance of the NEI network, observed in the Hcy+HFD group. The results indicated that NEI network may have a strong association with endothelial function, and this relationship can be used to distinguish different risk factors and evaluate drug effects.
The Center for Drug Clinical Research, Shanghai University of Chinese Medicine, Shanghai, China.
Lujin
L
Li
The Integration of Traditional and Western Medical Research Academy of Hebei Province, Shijiazhuang, China.
Zhenghua
Z
Jia
The Center for Drug Clinical Research, Shanghai University of Chinese Medicine, Shanghai, China.
Ling
L
Xu
The Integration of Traditional and Western Medical Research Academy of Hebei Province, Shijiazhuang, China.
Yiling
Y
Wu
The Center for Drug Clinical Research, Shanghai University of Chinese Medicine, Shanghai, China.
Qingshan
Q
Zheng
Endocrine system; Immune system; Nervous system; Vascular endothelial dysfunction