The role of SON in splicing, development, and disease.
SON is a nuclear protein involved in multiple cellular processes including transcription, pre-messenger RNA (mRNA) splicing, and cell cycle regulation. Although SON was discovered 25 years ago, the importance of SON's function was only realized recently when its roles in nuclear organization and pre-mRNA splicing as well as the influence of these activities in maintaining cellular health were unveiled. Furthermore, SON was implicated to have a key role in stem cells as well as during the onset of various diseases such as cancer, influenza, and hepatitis. Here we review the progress that has been made in studying this multifunctional protein and discuss questions that remain to be answered about SON.
Gene Regulation Laboratory, Genome Institute of Singapore, Singapore, Singapore.
Xinyi
X
Lu
Huck-Hui
HH
Ng
Paula A
PA
Bubulya
D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000235:genetics*; D053595:Embryonic Stem Cells / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006509:Hepatitis B / Q000235:genetics; D006801:Humans; D051379:Mice; D015778:Minor Histocompatibility Antigens; D009369:Neoplasms / Q000235:genetics; D012322:RNA Precursors / Q000378:metabolism*; D012326:RNA Splicing / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics*
D004268:DNA-Binding Proteins; D015778:Minor Histocompatibility Antigens; D012322:RNA Precursors; D012333:RNA, Messenger; C088203:SON protein, human