Long-term neuropsychological safety of subgenual cingulate gyrus deep brain stimulation for treatment-resistant depression.
Deep brain stimulation (DBS) of the subgenual cingulate gyrus (SCG) is a promising investigational intervention for treatment-resistant depression (TRD), but long-term outcome data are limited. Serial neuropsychological evaluations, using a comprehensive battery, were conducted on four subjects with TRD prior to surgery, and up to 42 months post-operatively. Reliable change methodology suggested general stability and/or select statistically reliable improvement in cognitive abilities over time. This is the first known set of multi-year neuropsychological follow-up data for SCG DBS for TRD. Observed improvements are likely attributable to reduced depressive symptomatology, recovery of functional capacities, and/or specific practice effects of repeated assessment.
Nicholas M
NM
Bogod
Marci
M
Sinden
Cindy
C
Woo
Vanessa G
VG
Defreitas
Ivan J
IJ
Torres
Andrew K
AK
Howard
Magdalena I
MI
Ilcewicz-Klimek
Christopher R
CR
Honey
Lakshmi N
LN
Yatham
Raymond W
RW
Lam
D000328:Adult; D003071:Cognition / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods*; D061218:Depressive Disorder, Treatment-Resistant / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome