Mean platelet volume is associated with glycaemic control and retinopathy in patients with type 2 diabetes mellitus.
OBJECTIVE
To investigate the relationship between mean platelet volume (MPV) and glycometabolic indices, to compare MPV according to HbA1c levels, and to analyse the difference in MPV between patients with and without microvascular complications.


METHODS
This retrospective study was conducted on 60 Type 2 diabetic patients and 50 age- and sex-matched non-diabetic controls. We obtained demographic, clinical and laboratory data including MPV, platelet count, fasting and postprandial blood glucose (FBG and PBG), haemoglobin A1c (HbA1c), lipid profile, creatinine, systolic and diastolic blood pressure (BP) in patient and control groups, and diabetic microvascular complications including nephropathy, neuropathy, and retinopathy in the patient group. All analyses were performed using SPSS version 15.0 for Windows.


RESULTS
Mean platelet volume in the diabetic group was higher than in the control group (p = 0.001). Mean platelet volume was positively correlated with FBG and HbA1c levels (p = 0.03 and p < 0.001, respectively). It was also negatively related to platelet count (p < 0.001). Mean platelet volume in patients with HbA1c > 7% was significantly higher than those with HbA1c ≤ 7% (p < 0.001). Mean platelet volume was significantly increased in patients with retinopathy compared to those without retinopathy (p = 0.04).


CONCLUSIONS
This study has shown that an increased MPV is closely associated with poor glycaemic control, which may be a risk factor for diabetic retinopathy. Nonetheless, further prospective studies are needed to assess the relationship between MPV, glycaemic indices and microvascular complications.
Department of Internal Medicine, Faculty of Medicine, University of Duzce, Duzce, Turkey.
S
S
Dindar
Department of Internal Medicine, Faculty of Medicine, University of Duzce, Duzce, Turkey.
H
H
Cinemre
Department of Nephrology, Kocaeli Derince Education and Research Hospital, Kocaeli, Turkey. dr.erkansengul@hotmail.com.
E
E
Sengul
Department of Chest Disease, Faculty of Medicine, University of Duzce, Duzce, Turkey.
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Annakkaya
D000328:Adult; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D012189:Retrospective Studies
D001786:Blood Glucose; D006442:Glycated Hemoglobin