Restricted puckering of mineralized RNA-like riboses.
The pseudorotational motions of highly hydroxylated pentafuranose sugars in the free state and tethered to hydroxyapatite have been compared. The conformation pentafuranose ring remains restricted at the North region of the pseudorotational wheel, which is the one typically observed for nucleosides and nucleotides in the double helix A-RNA, when the phosphate-bearing sugar is anchored to the mineral surface. Results indicate that the severe restrictions imposed by the mineral are responsible of the double helix preservation when DNA and RNA are encapsulated in crystalline nanorods.
Departament de Química, Escola Politècnica Superior, Universitat de Lleida , c/Jaume II no. 69, Lleida E-25001, Spain.
J
J
Casanovas
G
G
Revilla-López
O
O
Bertran
L J
LJ
Del Valle
P
P
Turon
J
J
Puiggalí
C
C
Alemán
D002236:Carbohydrate Conformation; D017886:Durapatite / Q000737:chemistry*; D006900:Hydroxylation; D007700:Kinetics; D008958:Models, Molecular; D009005:Monosaccharides / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D012399:Rotation; D013816:Thermodynamics
D009005:Monosaccharides; D012313:RNA; D017886:Durapatite