The effect of sodium hypochlorite and ginger extract on microorganisms and endotoxins in endodontic treatment of infected root canals.
This in vitro study sought to evaluate the biomechanical preparation action on microorganisms and endotoxins by using sodium hypochlorite (NaOCl) and an intracanal medication containing Zingiber officinale, with or without calcium hydroxide. Single-rooted teeth were contaminated, and root canal instrumentation (using 2.5% NaOCl) was performed. Samples were divided into 4 groups, according to the intracanal medication employed. The root canal content was gathered 28 days after contamination (baseline), immediately after biomechanical preparation, 7 days after biomechanical preparation, 14 days after intracanal medication, and 7 days after intracanal medication was removed. The results (submitted to Kruskal-Wallis and Dunn tests) showed that the NaOCl eliminated 100% of root canal microorganisms and reduced 88.8% of endotoxins immediately after biomechanical preparation, and 83.2% at 7 days after biomechanical preparation.
Marcia Carneiro
MC
Valera
Lilian Eiko
LE
Maekawa
Adriana
A
Chung
Flavia Goulart Rosa
FG
Cardoso
Luciane Dias de
LD
Oliveira
Carolina Lima de
CL
Oliveira
Claudio Antonio Talge
CA
Carvalho
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects; D003786:Dental Pulp Cavity / Q000382:microbiology*; D004731:Endotoxins / Q000037:antagonists & inhibitors*; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D020939:Zingiber officinale / Q000737:chemistry*; D006801:Humans; D066298:In Vitro Techniques; D010936:Plant Extracts / Q000627:therapeutic use*; D012389:Root Canal Obturation / Q000379:methods*; D012973:Sodium Hypochlorite / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D004731:Endotoxins; D010936:Plant Extracts; D012973:Sodium Hypochlorite
Zinziber officinale; calcium hydroxide; endotoxins; microorganisms; sodium hypochlorite