Immunomodulation in human and experimental arthritis: including vitamin D, helminths and heat-shock proteins.
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is mainly directed to the joints, affecting the synovial membrane, the cartilage and also the bone. This disease affects 1% to 2% of the world population and is associated with significant morbidity and increased mortality. RA experimental models have allowed a great deal of information to be translated to the corresponding human disease. This review summarizes some of the most relevant findings targeting immunomodulation in arthritis. Some general guidelines to choose an adequate experimental model and also our experience with arthritis are supplied.
1Department of Microbiology and Immunology, Biosciences Institute, Univ. Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil.
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LL
Ishikawa
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Y
Shoenfeld
A
A
Sartori
D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology* / Q000378:metabolism / Q000469:parasitology; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000378:metabolism / Q000469:parasitology; D015551:Autoimmunity; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism / Q000469:parasitology; D006360:Heat-Shock Proteins / Q000276:immunology* / Q000378:metabolism; D006376:Helminths / Q000276:immunology*; D006790:Host-Parasite Interactions; D006801:Humans; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism / Q000469:parasitology; D014807:Vitamin D / Q000276:immunology* / Q000378:metabolism
D006360:Heat-Shock Proteins; D014807:Vitamin D
Rheumatoid arthritis; dendritic cells; heat-shock proteins; helminths; regulatory T cells; vitamin D