The association between the polymorphism rs2231142 in the ABCG2 gene and gout risk: a meta-analysis.
Gout is a common metabolic disorder with high heritability. We tried to explore the association between rs2231142 and gout. We searched "rs2231142 or Q141K and gout" in four databases and scholar searching website until 1 June, 2013 and included data from 52,010 participants in meta-analysis and subgroup analysis. The T allele of rs2231142 was associated with increased gout susceptibility (odds ratio [OR] [95 % confidence interval (95 % CI)] = 1.73 [1.55-1.91], P < 0.001). It increased gout risk in Caucasians with OR (95 % CI) = 1.68 (1.50-1.87), P < 0.001; Asians with OR (95 % CI) = 1.93 (1.54-2.31), P < 0.001; Africans with OR (95 % CI) = 1.76 (1.15-2.36), P < 0.001; and New Zealand Pacific Islanders with OR (95 % CI) = 2.94 (1.72-4.15), P < 0.001, but not in New Zealand Maoris, with OR (95 % CI) = 1.12 (0.57-1.67), P = 0.061. No publish or other biases were observed. The T allele of rs2231142 was associated with increased risk of gout.
Department of Obesity and Metabolic Disorders, Guangdong Women and Children Hospital, 521 Xingnan Road, Guangzhou, 511400, China.
Xiaofei
X
Lv
Yuan
Y
Zhang
Fangfang
F
Zeng
Aihua
A
Yin
Ning
N
Ye
Haimei
H
Ouyang
Dan
D
Feng
Dan
D
Li
Wenhua
W
Ling
Xiaozhuang
X
Zhang
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000483:Alleles; D050197:Atherosclerosis / Q000235:genetics; D005006:Ethnicity; D005260:Female; D020022:Genetic Predisposition to Disease; D006073:Gout / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D009363:Neoplasm Proteins