Copper-catalyzed olefinic C-H difluoroacetylation of enamides.
Copper-catalyzed olefinic difluoroacetylation of enamides via direct C-H bond functionalization using BrCF2CO2Et is reported for the first time. It constitutes an efficient radical-free method for the regioselective synthesis of β-difluoroester substituted enamides which exhibits broad substrate scope, and thus demonstrates its potent application in a late stage fluorination strategy.
Institut de Chimie Organique et Analytique, UMR 7311 CNRS, Université d'Orléans, rue de Chartres, 45067 Orléans cedex 2, France. isabelle.gillaizeau@univ-orleans.fr.
Gilles
G
Caillot
Jérémy
J
Dufour
Marie-Charlotte
MC
Belhomme
Thomas
T
Poisson
Laurence
L
Grimaud
Xavier
X
Pannecoucke
Isabelle
I
Gillaizeau