Radiation therapy for Hodgkin lymphoma.
The long-term cardiac complications of radio(chemo)therapy for Hodgkin lymphoma include coronary artery disease, cardiac arrhythmias, valvular disease, pericardial disease, cardiomyopathy and heart failure. The extent of myocardial damage after radiotherapy is dependent on the dose, the volume and the technique of chest irradiation. Also, patient-specific factors, such as the age of the patient at the time of treatment and the presence of classical cardiac risk factors are supposed to be important. The relative risk of cardiovascular events is estimated to be 2 to 7 times higher than the general population. The patient's clinical picture can vary from asymptomatic to an acute presentation of end-stage coronary artery or valvular disease.
Bert R
BR
Everaert
Paul
P
Van den Heuvel
D000328:Adult; D001022:Aortic Valve Insufficiency / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D054059:Coronary Occlusion / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D023921:Coronary Stenosis / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000528:radiation effects*; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects*; D012307:Risk Factors; D013616:Tachycardia, Sinus / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome