Two wavelength Mueller matrix reconstruction of blood plasma films polycrystalline structure in diagnostics of breast cancer.
The model of a Mueller matrix description of mechanisms of optical anisotropy typical for polycrystalline films of blood plasma--optical activity, birefringence, as well as linear and circular dichroism--is suggested. On this basis, the algorithms of reconstruction of parameters distribution (polarization plane rotations, phase shifts, coefficients of linear and circular dichroism) of the indicated types of anisotropy were found for different spectrally selective ranges. Within the statistical analysis of such distributions, the objective criteria of differentiation of films of blood plasma taken from healthy women and breast cancer patients were determined. From the point of view of probative medicine, the operational characteristics (sensitivity, specificity and accuracy) of the method of Mueller matrix reconstruction of optical anisotropy parameters were found, and its efficiency in diagnostics of breast cancer was demonstrated.
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Ushenko
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Dubolazov
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Karachevtsev
D000465:Algorithms; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology*; D003460:Crystallization; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008027:Light; D008859:Microscopy, Polarization / Q000379:methods*; D010949:Plasma / Q000166:cytology*; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity