Disrupted modular architecture of cerebellum in schizophrenia: a graph theoretic analysis.
Recent studies of schizophrenia have revealed cognitive and memory deficits that are accompanied by disruptions of neuronal connectivity in cortical and subcortical brain regions. More recently, alterations of topological organization of structural networks in schizophrenia are also being identified using graph theoretical analysis. However, the role of the cerebellum in this network structure remains largely unknown. In this study, global network measures obtained from diffusion tensor imaging were computed in the cerebella of 25 patients with schizophrenia and 36 healthy volunteers. While cerebellar global network characteristics were slightly altered in schizophrenia patients compared with healthy controls, the patients showed a retained small-world network organization. The modular architecture, however, was changed mainly in crus II. Furthermore, schizophrenia patients had reduced correlations between modularity and microstructural integrity, as measured by fractional anisotropy (FA) in lobules I-IV and X. Finally, FA alterations were significantly correlated with the Positive and Negative Syndrome Scale symptom scores in schizophrenia patients. Taken together, our data suggest that schizophrenia patients have altered network architecture in the cerebellum with reduced local microstructural connectivity and that cerebellar structural abnormalities are associated symptoms of the disorder.
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN;
Dae-Jin
DJ
Kim
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN;
Jerillyn S
JS
Kent
Amanda R
AR
Bolbecker
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN;
Olaf
O
Sporns
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN; Imaging Research Facility, Indiana University, Bloomington, IN.
Hu
H
Cheng
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN; Imaging Research Facility, Indiana University, Bloomington, IN.
Sharlene D
SD
Newman
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN; Imaging Research Facility, Indiana University, Bloomington, IN.
Aina
A
Puce
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN;
Brian F
BF
O'Donnell
whetrick@indiana.edu.
William P
WP
Hetrick
D000328:Adult; D002531:Cerebellum / Q000473:pathology* / Q000503:physiopathology; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000473:pathology* / Q000503:physiopathology; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology
cerebellum; diffusion tensor imaging; modular architecture; schizophrenia; structural connectivity; structural network