A fruit fly in the nanoworld: once again Drosophila contributes to environment and human health.
Drosophila was the most important model organism used in the fields of medicine and biology over the last century. Recently, Drosophila was successfully used in several studies in the field of nanotoxicology. However, only a part of its potential has been exploited in this field until now. In fact, apart from macroscopic observations of the effect due to the interaction between nanomaterials and living organism (i.e. lifespan, fertility, phenotypic aberrations, etc.), Drosophila has the potential to be a very useful tool to deeply analyze the molecular pathways involved in response to the interactions at nano-bio level. The aim of this editorial is to encourage the use of Drosophila by the different research groups working in the fields of nanotoxicology and nanomedicine, in order to define the effects induced by nanomaterials at molecular level for their subsequent exploitation in the field of nanomedicine.
Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies@UniLe , Arnesano, Lecce 73010 , Italy.
Giuseppe
G
Vecchio
D000818:Animals; D001681:Biological Assay / Q000379:methods; D004330:Drosophila / Q000187:drug effects* / Q000502:physiology*; D004781:Environmental Exposure / Q000009:adverse effects*; D004782:Environmental Health / Q000379:methods; D006801:Humans; D023421:Models, Animal; D053758:Nanoparticles / Q000008:administration & dosage / Q000633:toxicity*; D013045:Species Specificity; D018675:Toxicity Tests / Q000379:methods*
Nanomedicine; nanotoxicology; particle toxicology; risk assessment