Structural and morphological investigations of β-cyclodextrin-coated silver nanoparticles.
This paper describes the synthesis of silver nanoparticles using an aqueous silver nitrate solution in the presence of glucose as a reducing agent, sodium hydroxide as a reaction catalyst and β-CD as a stabilizer. The structure and the morphology associated to the stabilizing layer around the silver nanoparticles were investigated. Raman spectroscopy confirmed the nanoparticle surface modification by β-CD, demonstrating the interaction between the β-CD rim hydroxyl groups and the AgNP surface. Transmission electron microscopy images showed an average 28.0nm diameter pseudo-spherical nanoparticles. Apart from this, a novel characterization of the β-CD layer surrounding the nanoparticles was carried out by using complementary analytical electron microscopy based on electron spectroscopy imaging in the transmission microscope. Mapping images revealed the presence of carbon and oxygen, demonstrating the existence of a uniform and interacting β-CD layer covering the nanoparticles. The antibacterial activity was also investigated and the β-CD-coated silver nanoparticles showed a promising bactericidal activity against the microorganism Escherichia coli.
Institute of Chemistry, University of Campinas (UNICAMP), P.O. Box 6154, Campinas, SP 13083-970, Brazil.
Patricia Fernanda
PF
Andrade
Institute of Chemistry, University of Campinas (UNICAMP), P.O. Box 6154, Campinas, SP 13083-970, Brazil.
Andreia Fonseca
AF
de Faria
Institute of Chemistry, University of Campinas (UNICAMP), P.O. Box 6154, Campinas, SP 13083-970, Brazil.
Douglas Soares
DS
da Silva
Institute of Chemistry, University of Campinas (UNICAMP), P.O. Box 6154, Campinas, SP 13083-970, Brazil.
Juliano Alves
JA
Bonacin
Institute of Chemistry, University of Campinas (UNICAMP), P.O. Box 6154, Campinas, SP 13083-970, Brazil. Electronic address: maria@iqm.unicamp.br.
Maria do Carmo
Mdo C
Gonçalves
D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D010316:Particle Size; D044224:Pseudomonas syringae / Q000187:drug effects; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013818:Thermogravimetry; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000494:pharmacology
D020099:Coated Materials, Biocompatible; D012996:Solutions; D047392:beta-Cyclodextrins; D012834:Silver; C031215:betadex
Antibacterial activity; Silver nanoparticles; Stabilizing layer; β-Cyclodextrin