Comparative evaluation of opioid-induced changes in immune reactivity of CBA mice.
Comparison of IgM and IgG-humoral immune response of CBA mice immunized with SE (5 × 10(8) cells) to activation of μ- (DAGO, 100 μg/kg) and δ2- (DSLET, 100 μg/kg) opioid receptors was studied. Different effects of opioids on IgM and IgG antibody production and peripheral blood and spleen levels of CD4(+) and CD8(+) subpopulations were detected at the peak of immune response under these conditions.
Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia, cheido@physiol.ru.
M A
MA
Cheido
M M
MM
Gevorgyan
E N
EN
Zhukova
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D007107:Immune System / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D018847:Opioid Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017465:Receptors, Opioid, delta / Q000187:drug effects; D017450:Receptors, Opioid, mu / Q000187:drug effects
D018847:Opioid Peptides; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu