Making connections: interorganelle contacts orchestrate mitochondrial behavior.
Mitochondria are highly dynamic organelles. During their life cycle they frequently fuse and divide, and damaged mitochondria are removed by autophagic degradation. These processes serve to maintain mitochondrial function and ensure optimal energy supply for the cell. It has recently become clear that this complex mitochondrial behavior is governed to a large extent by interactions with other organelles. In this review, we describe mitochondrial contacts with the endoplasmic reticulum (ER), plasma membrane, and peroxisomes. In particular, we highlight how mitochondrial fission, distribution, inheritance, and turnover are orchestrated by interorganellar contacts in yeast and metazoa. These interactions are pivotal for the integration of the dynamic mitochondrial network into the architecture of eukaryotic cells.
Institut für Zellbiologie, Universität Bayreuth, 95440 Bayreuth, Germany.
Till
T
Klecker
Institut für Zellbiologie, Universität Bayreuth, 95440 Bayreuth, Germany.
Stefan
S
Böckler
Institut für Zellbiologie, Universität Bayreuth, 95440 Bayreuth, Germany. Electronic address: benedikt.westermann@uni-bayreuth.de.
Benedikt
B
Westermann
D000818:Animals; D001343:Autophagy / Q000235:genetics; D002462:Cell Membrane / Q000235:genetics / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000235:genetics / Q000378:metabolism*; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D015388:Organelles / Q000235:genetics / Q000378:metabolism*; D020675:Peroxisomes / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
endoplasmic reticulum; mitochondria; organelle contact sites; peroxisomes; plasma membrane