Drug-induced hepatotoxicity: metabolic, genetic and immunological basis.
Drug-induced hepatotoxicity is a significant cause of acute liver failure and is usually the primary reason that therapeutic drugs are removed from the commercial market. Multiple mechanisms can culminate in drug hepatotoxicity. Metabolism, genetics and immunology separately and in concert play distinct and overlapping roles in this process. This review will cover papers we feel have addressed these mechanisms of drug-induced hepatotoxicity in adults following the consumption of commonly used medications. The aim is to generate discussion around "trigger point" papers where the investigators generated new science or provided additional contribution to existing science. Hopefully these discussions will assist in uncovering key areas that need further attention.
Departments of Anesthesiology and Critical Care Medicine, Pediatrics and Pathology, Johns Hopkins University, 1800 Orleans Street, Suite 6349, Baltimore, MD 21287, USA. dnjoku@jhmi.edu.
Dolores B
DB
Njoku
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D018925:Chemokines / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D011110:Polymorphism, Genetic; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D018925:Chemokines; D006680:HLA Antigens; D003577:Cytochrome P-450 Enzyme System