Systemic effects of TRAIL (TNF-related apoptosis-inducing ligand) during acute γ-irradiation.
The effects of TRAIL at various physiological levels were studied on 101/Hf and C3H/Sn mice during acute γ-irradiation with 750 R. An intravenous injection of TRAIL attenuated the effects of γ-irradiation on the body weight, subfractions of blood plasma, horizontal and vertical activity in the open-field test, tissue injury in the small intestine and liver, and content of Hassall's corpuscles in the thymus. The degree of these changes differed in mice of study strains.
Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia, labpolys@gmail.com.
E N
EN
Arkhipova
I B
IB
Alchinova
A B
AB
Cherepov
D V
DV
Rozanov
Yu S
YS
Medvedeva
M Yu
MY
Karganov
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays; D008297:Male; D008809:Mice, Inbred C3H; D009043:Motor Activity / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011836:Radiation Tolerance / Q000187:drug effects; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000008:administration & dosage*
D011837:Radiation-Protective Agents; D053221:TNF-Related Apoptosis-Inducing Ligand