Synthesis and characterization of poly[N-isopropylacrylamide-co-1-(N,N-bis-carboxymethyl)amino-3-allylglycerol] grafted to magnetic nano-particles for the extraction and determination of fluvoxamine in biological and pharmaceutical samples.
In this research, a novel method is reported for the surface grafting of N-isopropylacrylamide as a thermosensitive agent and 1-(N,N-bis-carboxymethyl)amino-3-allylglycerol with an affinity toward fluvoxamine onto magnetic nano-particles modified by 3-mercaptopropyltrimethoxysilane. The grafted nano-particles were characterized by Fourier transform infrared spectroscopy, elemental analysis, and thermogravimetric analysis. The surface morphology was studied with scanning electron microscopy and transmission electron microscopy. The resulting grafted nano-particles were used in solid phase extraction and determining of trace fluvoxamine in biological human fluids and pharmaceutical samples. The profile of the fluvoxamine uptake by the modified magnetic nano-particles indicated good accessibility of the active sites in the grafted copolymer. It was found that the adsorption behavior could be fitted by the Freundlich adsorption isotherm model. It was observed that a maximum amount of fluvoxamine was released at a temperature above the lower critical solution temperature of the polymer.
Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran. Electronic address: h.ahmadpanahi@iauctb.ac.ir.
Homayon Ahmad
HA
Panahi
Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Yasamin
Y
Tavanaei
Department of Chemistry, Varamin (Pishva) Branch, Islamic Azad University, Varamin, Iran.
Elham
E
Moniri
Department of Chemistry, Karaj Branch, Islamic Azad University, Varamin, Iran.
Elham
E
Keshmirizadeh
D000178:Acrylamides / Q000138:chemical synthesis* / Q000737:chemistry; D016666:Fluvoxamine / Q000032:analysis*; D005990:Glycerol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D052616:Solid Phase Extraction / Q000379:methods*; D013696:Temperature
D000178:Acrylamides; D058185:Magnetite Nanoparticles; D011108:Polymers; C000592298:poly(N-isopropylacrylamide-co-1-(N,N-bis-carboxymethyl)amino-3-allylglycerol); D016666:Fluvoxamine; D005990:Glycerol
Enteric drug delivery; Fluvoxamine; Human biological fluids; Magnetic nano-particles; Pharmaceutical samples; Solid phase extraction