[Progress in the study of core-crosslinked polymeric micelles in drug delivery system].
The core-crosslinked polymeric micelles were used as a new drug delivery system, which can decrease the premature drug release in blood circulation, improve the stability of the micelles, and effectively transport the drug into the therapy sites. Then the drug bioavailability increased further, while the side effect reduced. Most drugs were physically entrapped or chemically covalent with the polymer in the internals of micelles. Based on the various constitutions and properties of polymeric micelles as well as the special characteristics of body microenvironment, the environment-responsive or active targeting core-crosslinked micelles were designed and prepared. As a result, the drug controlled release behavior was obtained. In the present paper, the research progress of all kinds of core-crosslinked micelles which were published in recent years is introduced. Moreover, the characteristic and application prospect of these micelles in drug delivery system are analyzed and summarized.
Jing-Mou
JM
Yu
Jia-Zhong
JZ
Wu
Xin-Shi
XS
Wang
Yi
Y
Jin
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D003432:Cross-Linking Reagents / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008823:Micelles; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism
D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D008823:Micelles; D004364:Pharmaceutical Preparations; D011108:Polymers; D011092:Polyethylene Glycols