HLA-B35, a common genetic trait, in a familial case of Henoch-Schoenlein purpura and Berger's disease.
Nephritis characterized by IgA mesangial depositions has been described both in Henoch-Schoenlein purpura (HSP) and in Berger's disease (BD), but common genetic traits are still uncertain. We report here the case of two brothers, the first affected by HSP with persistent nephritis and the second by BD, accidentally discovered as silent microhematuria 1 year after HSP onset in the first brother. HLA genotyping demonstrated the presence of HLA-B35 in both patients. Our findings reinforce the need to screen for urinary abnormalities in family members of patients affected by HSP nephritis to identify a silent IgA nephropathy.
University of Trieste, Trieste, Italy mariachiara.pellegrin@gmail.com.
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MC
Pellegrin
University of Trieste, Trieste, Italy.
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L
Matarazzo
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
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E
Neri
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
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M
Pennesi
University of Trieste, Trieste, Italy.
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Crovella
D000293:Adolescent; D002648:Child; D005260:Female; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000235:genetics* / Q000473:pathology; D015797:HLA-B35 Antigen / Q000235:genetics*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D010641:Phenotype
D015797:HLA-B35 Antigen