Filaggrin-insufficiency in keratinocytes influences responsiveness of allergen-specific T cells to cognate antigen and compounds barrier function deficiency.
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Ishita
I
Marwah
Department of Periodontology and Oral Medicine, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Xinwen
X
Wang
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Hsien
H
Chan
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Graham S
GS
Ogg
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. Electronic address: danuta.gutowska-owsiak@ndm.ox.ac.uk.
Danuta
D
Gutowska-Owsiak
D000485:Allergens / Q000276:immunology*; D000091344:Filaggrin Proteins; D006801:Humans; D007381:Intermediate Filament Proteins / Q000172:deficiency / Q000235:genetics*; D015603:Keratinocytes / Q000378:metabolism*; D012867:Skin / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*
D000485:Allergens; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins
Antigen-experienced T cells; Der p 1; Filaggrin; House dust mite; Skin barrier