The osteogenic effects of swimming, jumping, and vibration on the protection of bone quality from disuse bone loss.
We assessed and compared the effects of swimming, jumping, and vibration therapies on the prevention of bone loss because of unloading. Eighty Wistar rats were randomly divided into eight groups: S, permanent hind limb-suspended rats; CON, control rats; S + Swim, unloading interrupted by swimming exercise; S + C(Swim), suspension interrupted by regular weight-bearing with the same duration as in the S + Swim protocol; S + Jump, unloading interrupted by jumping exercise; S + C(Jump), suspension interrupted for regular weight-bearing as in the S + Jump group; S + Vibr, unloading interrupted by vibration; and S + C(Vibr), suspension with interruptions for regular weight-bearing with the same protocol as that used for the S + Vibr rats. At the end of the experiment, the bone mineral density, bone strength, histomorphometric parameters, and serum levels of the bone markers were analyzed. The hind limb-suspended rats exhibited bone quality loss. In contrast, the trained rats showed a significant increase in bone mass, bone strength, bone formation, and serum levels of bone markers compared with the respective controls. Although we did not find a significant difference among the three physical exercises, the osteogenic effect of vibration was slightly lower than that of swimming and jumping. Thus, all physical exercises were efficient in preventing bone loss because of unloading and preserving bone quality.
Laboratory of Bioengineering, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil.
M J
MJ
Falcai
Laboratory of Bioengineering, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil.
A
A
Zamarioli
Laboratory of Bioengineering, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil.
R
R
Okubo
Department of Internal Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil.
F J A
FJ
de Paula
Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil.
J B
JB
Volpon
D015502:Absorptiometry, Photon; D000818:Animals; D015519:Bone Density; D005269:Femur / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D010006:Osteoblasts / Q000502:physiology*; D015675:Osteocalcin / Q000097:blood; D010010:Osteoclasts / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013550:Swimming / Q000502:physiology*; D014732:Vibration; D016474:Weight-Bearing
C548904:insulin-like growth factor-1, rat; D015675:Osteocalcin; D007334:Insulin-Like Growth Factor I
Osteoporosis; bone tissue; exercise therapy; osteoblasts; osteoclasts; osteogenesis; tail suspension