QT dispersion increases with low glomerular filtration rate in patients with coronary artery disease.
OBJECTIVE
We aimed to evaluate the relationship between estimated glomerular filtration rate (eGFR) and QT dispersion (QTd) in patients with coronary artery disease (CAD).


METHODS
Sixty patients(mean age 62.72 ± 12.48 years) included 46 male, (mean age 60.89 ± 12.70 years)and 14 female (mean age 68.71± 9.86 years) were enrolled in this study. Patients were divided into 2 groups according to their eGFR using the 6 variable MDRD equation. Group 1 consisted of patients with estimated eGFR<60 ml/min/1.73m(2) and Group 2 consisted of patients witheGFR ≥ 60 ml/min/1.73m(2).


RESULTS
Baseline patient characteristics were homogeneous in both groups except for age, gender and smoking.Also, the extent of CAD was similar in both groups (p > 0.05) QTd values were found higher in group 1 than those of group 2 (57.23 ± 40.65 ms vs. 31.23 ± 14.47 ms, p = 0.002). After adjustment for age, gender and smoking using one-way ANCOVA test, statistically significant difference in QTd still existedbetween the groups (p=0.038).


CONCLUSIONS
QTd tends to be higher in patients with poor renal function independent of severity of angiographical CAD. QTd may be a potentially useful non-invasive test in the management of patients with poor renal function, especially those with CAD.
Murat Celik, Department of Cardiology, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey.
Murat
M
Celik
UygarCagdasYuksel, Department of Cardiology, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey.
Uygarcagdas
U
Yuksel
YalcinGokoglan, Department of Cardiology, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey.
Yalcin
Y
Gokoglan
BarisBugan, Department of Cardiology, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey.
Baris
B
Bugan
EmreYalcinkaya, Department of Cardiology, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey.
Emre
E
Yalcinkaya
Hilmi Umut Unal, Department of Nephrology, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey.
Hilmiumut
H
Unal
TurgayCelik, Department of Cardiology, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey.
Turgay
T
Celik
AtilaIyisoy, Department of Cardiology, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey.
Atila
A
Iyisoy
SelimKilic, Department of Epidemiology, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey.
Selim
S
Kilic
Coronary artery disease; Glomerular filtration rate; QT dispersion