[B-type natriuretic peptide and high sensitivity troponin T as a marker of cardiac failure in patients after permanent cardiac pacing].
Both B-type natriuretic peptide and high sensitivity troponin T play the role in the clinical practice now. Examination of this markers is important in ischaemic heart disease, chronic heart failure, pulmonary embolismus, after cardio-pulmonary resuscitations,electrotherapy and renal insufficienty. The aim of this study was to demonstrate the impact of permanent cardiac pacing on selected biochemical parameters of the cardiovascular system, such as the B-type natriuretic peptide and high-sensitivity troponin levels, and usefulness of this biochemical parameters in daily practice.


METHODS
The study involved 195 people. Finally, 117 patients completed the study. There were distinguished: group I--21 patients with pacemaker AAI/R, group II--59 patients with a pacemaker DDD/R, group III--37 patients with pacemaker VVI/R, a control group--48 healthy subjects of comparable age.In the treatment groups (group I, II, and III) peptide BNP, troponin T detected by high-sensitivity assay, were performed three times. In the control group the same tests were performed once.


RESULTS
In the group II blood concentration of B-type natriuretic peptide 3 month after implantation DDD/R was elevated from 157.27 +/- 186.34 microg/1000 microl to 214.46 +/- 249.54 pg/1000microl and was statistical signification higher from the period before implantation ( p < 0.001). 6 month after implantation DDD/R blood concentration of B - type natriuretic peptide was 219.15 +/- 257.59 microg/1000 microl and was statistical significantly higher compared to period before implantation (p < 0.001). In the group II high sensitivity troponin T after implantation elevated from 10.42 +/- 12.81 ng/ml to 17.08 +/- 38.86 ng/ml (p < 0.05).


CONCLUSIONS
In the group with DDD/R blood concentration of B-type natriuretic paptide and high sensitivity troponin T are elevated. Both B-type natriuretic peptide and high sensitivity troponin T play important role in examinations patients after cardiac pacing implantations. Cardiac examination after implantation pacing should be completed by B-type natriuretic peptide and high sensitivity troponin T examinations.
Janusz
J
Sielski
D015415:Biomarkers / Q000097:blood; D002304:Cardiac Pacing, Artificial / Q000009:adverse effects*; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012680:Sensitivity and Specificity; D020107:Troponin T / Q000097:blood*
D015415:Biomarkers; D020107:Troponin T; D020097:Natriuretic Peptide, Brain