The regulation of autophagy by influenza A virus.
Influenza A virus is a dreadful pathogen of animals and humans, causing widespread infection and severe morbidity and mortality. It is essential to characterize the influenza A virus-host interaction and develop efficient counter measures against the viral infection. Autophagy is known as a catabolic process for the recycling of the cytoplasmic macromolecules. Recently, it has been shown that autophagy is a critical mechanism underlying the interaction between influenza A virus and its host. Autophagy can be induced by the infection with influenza A virus, which is considered as a necessary process for the viral proliferation, including the accumulation of viral elements during the replication of influenza A virus. On the other hand, influenza A virus can inhibit the autophagic formation via interaction with the autophagy-related genes (Atg) and signaling pathways. In addition, autophagy is involved in the influenza virus-regulated cell deaths, leading to significant changes in host apoptosis. Interestingly, the high pathogenic strains of influenza A virus, such as H5N1, stimulate autophagic cell death and appear to interplay with the autophagy in distinct ways as compared with low pathogenic strains. This review discusses the regulation of autophagy, an influenza A virus driven process.
College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Rong
R
Zhang
College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Xiaojuan
X
Chi
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, China.
Song
S
Wang
College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Baomin
B
Qi
Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri, Kansas City, MO 64110, USA.
Xiaoqiang
X
Yu
College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China ; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, China.
Ji-Long
JL
Chen
D017209:Apoptosis / Q000235:genetics; D001343:Autophagy / Q000235:genetics*; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics* / Q000378:metabolism; D007251:Influenza, Human / Q000235:genetics* / Q000473:pathology / Q000821:virology; D015398:Signal Transduction / Q000235:genetics