[Correlation study between ischemic stroke and polymorphism of human leucocyte antigen gene].
OBJECTIVE
To explore the correlation between ischemic stroke (IS) and the polymorphism of human leucocyte antigen (HLA) gene.


METHODS
Antigen, allele, haplotype of HLA-A, B, C, DRB1, DQB1 in 94 IS patients and 503 healthy controls were detected by PCR-SBT.


RESULTS
(1) There were 11 antigens, 17 alleles in HLA-A locus, 20 antigens, 34 alleles in HLA-B locus, 11 antigens, 16 alleles in HLA-C locus, 13 antigens, 26 alleles in HLA-DRB1 locus, 5 antigens, 13 alleles in HLA- DQB1 locus in IS group.(2) The allelic frequency of HLA-A*31: 01 (P = 0.016 9, RR = 2.827) , HLA-B* 37: 01 (P = 0.006 6, RR = 4.613) and HLA-DRB1*11: 06 (P = 0.000 2, RR = 37.981) in the IS patients was higher than that in healthy controls.(3) The haplotypic frequency of HLA-DRB1*11: 06-DQB1*03: 01 (P = 0.001, RR = 38.52) in the IS patients was higher than that in healthy controls.


CONCLUSIONS
The susceptibility association of HLA-B*37: 01, HLA-DRB1*11: 06 and HLA-DRB1*11: 06-DQB1*03: 01 with IS and HLA gene play a genetic role in the occurrence of.
Department of Geratology, Affiliated Nanshan Hospital, Guangdong Medical College, Shenzhen 518067, China.
Wei
W
Chen
Huiyu
H
Feng
Mingming
M
Xu
Xiuping
X
Jia
Liangling
L
Cai
Lulu
L
Xiao
Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Email: ranliuz@163.com.
Weibin
W
Liu
D000368:Aged; D000483:Alleles; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D015236:HLA-C Antigens / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000235:genetics*
D015236:HLA-C Antigens; D006683:HLA-DQ Antigens; D059811:HLA-DRB1 Chains