Gene regulatory networks in the immune system.
We describe examples of genomic control circuits that underlie developmental transitions and cellular activation states within the immune system. The architectures of simple gene regulatory networks (GRNs) are highlighted to emphasize conservation of regulatory motifs. The regulatory logic and the cell fate dynamics of each simple GRN, the latter revealed by mathematical and computational modeling, are elaborated. This framework is being expanded to enable the assembly and analysis of complex GRNs using genomic, computational, and high-throughput experimental methodologies. The paradigm will provide new insights into immune cell development and function, and into the pathophysiology of autoimmune and inflammatory disorders, as well as immune malignancies.
Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Harinder.Singh@cchmc.org.
Harinder
H
Singh
Department of Human Genetics and the Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, USA.
Aly A
AA
Khan
Department of Chemistry and the James Franck Institute, The University of Chicago, Chicago, IL, USA.
Aaron R
AR
Dinner
D000818:Animals; D001665:Binding Sites; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007109:Immunity / Q000235:genetics*; D008954:Models, Biological; D059372:Nucleotide Motifs; D011485:Protein Binding; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors / Q000378:metabolism
D014157:Transcription Factors