Estimation of size of cord blood inventory based on high-resolution typing of HLAs.
Methods for estimating the cord blood (CB) inventory size required vary according to the ethnic diversity of the HLA, degree of HLA matching and HLA-typing resolution. We estimated the CB inventory size required using 7190 stored CB units (CBU) and 2450 patients who were awaiting or underwent allogeneic hematopoietic stem cell transplantation. With high-resolution typing of HLA-A, B and DRB1, 94.6% of Korean patients could find CBUs in 100 000 CBUs with a 5/6 match, and 95.7% could find CBUs in 5000 CBUs with a 4/6 match. With low-resolution typing of HLA-A and B and high-resolution typing of leukocyte antigen-DRB1, 95% of patients could find CBUs in 50 000 CBUs with a 5/6 match, and 96.7% could find CBUs in 3000 CBUs  with a 4/6 match. With additional high-resolution typing for HLA-A and B, which could improve transplantation outcome, the size of the CB inventory would need to increase twofold for Koreans.
Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
E Y
EY
Song
CHA Bundang Medical Center, Department of Laboratory Medicine, CHA University, Seongnam, Korea.
J Y
JY
Huh
Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Korea.
S Y
SY
Kim
Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Korea.
T G
TG
Kim
Department of Biostatistics, Boramae Hospital, Seoul, Korea.
S
S
Oh
1] Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea [2] Department of Laboratory Medicine, Boramae Hospital, Seoul, Korea [3] Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea.
J H
JH
Yoon
1] Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea [2] Department of Laboratory Medicine, Boramae Hospital, Seoul, Korea [3] Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea.
E Y
EY
Roh
Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
M H
MH
Park
1] CHA Bundang Medical Center, Department of Laboratory Medicine, CHA University, Seongnam, Korea [2] CHA Medical Center Cord Blood Bank, Seongnam, Korea.
M S
MS
Kang
1] Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea [2] Department of Laboratory Medicine, Boramae Hospital, Seoul, Korea [3] Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea.
S
S
Shin
D000094902:Blood Banking / Q000379:methods*; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D008297:Male
D006680:HLA Antigens