Dual-function Pd/NHC catalysis: tandem allylation-isomerization-conjugate addition that allows access to pyrroles, thiophenes and furans.
An efficient coupling reaction of allyl acetate with (O-azaaryl)carboxaldehyde by Pd-NHC dual catalysis has been developed. This reaction proceeds via direct coordination between the ortho nitrogen atom in the heterocycle and Pd(0). This dual catalysis is achieved under mild conditions to give 1,4-diones as products with up to 90% yield.
School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Drive, Singapore 637371. xuewei@ntu.edu.sg.
Yaguang
Y
Bai
Shaohua
S
Xiang
Min Li
ML
Leow
Xue-Wei
XW
Liu