Role of pomegranate and citrus fruit juices in colon cancer prevention.
Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Recent studies prove that though chemotherapeutic agents are being used for the treatment of colon cancer, they become non-effective when the cancer progresses to an invasive stage. Since consumption of certain dietary agents has been linked with various cancers, fruit juices have been investigated for their consistently protective effect against colon cancer. The unique biochemical composition of fruit juices is responsible for their anticancer properties. In this review, the chemo-preventive effect of fruit juices such as pomegranate and citrus juices against colon cancer are discussed. For this purpose, the bioavailability, in vitro and in vivo effects of these fruit juices on colorectal cancer are highlighted. Moreover, there is a scarcity of studies involving human trials to estimate the preventive nature of these juices against colon cancer. This review will support the need for more preclinical tests with these crude juices and their constituents in different colorectal cancer cell lines and also some epidemiological studies in order to have a better understanding and promote pomegranate and citrus juices as crusaders against colon cancer.
Saravana Kumar Jaganathan, Eko Supriyanto, IJN-UTM Cardiovascular Engineering Centre, Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia.
Saravana Kumar
SK
Jaganathan
Saravana Kumar Jaganathan, Eko Supriyanto, IJN-UTM Cardiovascular Engineering Centre, Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia.
Muthu Vignesh
MV
Vellayappan
Saravana Kumar Jaganathan, Eko Supriyanto, IJN-UTM Cardiovascular Engineering Centre, Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia.
Gayathri
G
Narasimhan
Saravana Kumar Jaganathan, Eko Supriyanto, IJN-UTM Cardiovascular Engineering Centre, Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia.
Eko
E
Supriyanto
D000284:Administration, Oral; D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D001628:Beverages; D045744:Cell Line, Tumor; D002957:Citrus; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D005638:Fruit; D006801:Humans; D029561:Lythraceae; D008517:Phytotherapy; D010946:Plants, Medicinal
D016588:Anticarcinogenic Agents
Chemoprevention; Citrus fruits; Colon cancer; Fruit juices; Pomegranate