Novel individual metabolic profile characterizes the protein kinase B-alpha (pkbα-/-) in vivo model.
BACKGROUND
Type 2 diabetes and associated co-morbidities run epidemic waves worldwide. Since pathophysiological constellations are individual and display a wide spread of dysmetabolic profiles personalized health care assessments start to emerge. Therefore, we established a specific in silico assessment tool targeting metabolic characterizations individually.


METHODS
Values obtained from oral glucose and intraperitoneal insulin tolerance tests performed on pkbα(-/-) mice (KO) as well as age- and gender-matched controls (WT) were analysed using our established in silico model.


RESULTS
Generally, male pkbα(-/-) mice (KO) presented significantly increased insulin sensitivity at an age of 6 months compared with age-matched WTs (p = 0.036). Female KO and WT groups displayed improved glucose sensitivities compared with age-matched males (for WT p ≤ 0.011).


CONCLUSIONS
Specific metabolic characterization should be assessed individually. Therefore, our in silico model enables novel insights inaugurating specific primary preventive strategies targeting individual metabolic profiling precisely.
UniversitätsSpital Zürich, Abteilung für Endokrinologie , Diabetologie & Klin. Ernährung, 8091 Zürich , Switzerland .
Claudia
C
Eberle
Markus
M
Niessen
Brian A
BA
Hemmings
Oliver
O
Tschopp
Christoph
C
Ament
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003198:Computer Simulation; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D055786:Gene Knockout Techniques; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D007333:Insulin Resistance; D008297:Male; D055432:Metabolomics; D051379:Mice; D008954:Models, Biological; D051057:Proto-Oncogene Proteins c-akt / Q000172:deficiency* / Q000235:genetics
D001786:Blood Glucose; D007328:Insulin; D051057:Proto-Oncogene Proteins c-akt
Diabetes; in silico modelling; individualized medicine; metabolic profiling; protein kinase B-alpha (pkbα)