Adsorption properties of biologically active derivatives of quaternary ammonium surfactants and their mixtures at aqueous/air interface II. Dynamics of adsorption, micelles dissociation and cytotoxicity of QDLS.
The main aim of our study was analysis of adsorption dynamics of mixtures containing quaternary derivatives of lysosomotropic substance (QDLS). Two types of equimolar mixtures were considered: the ones containing two derivatives of lysosomotropic substances (DMALM-12 and DMGM-12) as well as the catanionic mixtures i.e. the systems containing QDLS and DBSNa. Dynamic surface tension measurements of surfactant mixtures were made. The results suggested that the diffusivity of the mixed system could be treated as the average value of rates of diffusion of individual components, micelles and ion pairs, which are present in the mixtures studied. Moreover, an attempt was made to explain the influence of the presence of micelles in the mixtures on their adsorption dynamics. The compounds examined show interesting biological properties which can be useful, especially for drug delivery in medical treatment. In vitro cytotoxic activities of the mixtures studied towards human cancer cells were evaluated. Most of the mixtures showed a high antiproliferative potential, especially the ones containing DMALM-12. Each cancer cell line used demonstrated different sensitivity to the same dose of the mixtures tested.
Poznan University of Technology, Institute of Chemical Technology and Engineering, Pl. M. Skłodowskiej-Curie 2, 60-965 Poznań, Poland.
Monika
M
Rojewska
Poznan University of Technology, Institute of Chemical Technology and Engineering, Pl. M. Skłodowskiej-Curie 2, 60-965 Poznań, Poland. Electronic address: krystyna.prochaska@put.poznan.pl.
Krystyna
K
Prochaska
Department of Biotechnology, Food Microbiology, Poznan University of Life Sciences, ul. Wojska Polskiego 48, 60-627 Poznań, Poland.
Anna
A
Olejnik
Department of Biotechnology, Food Microbiology, Poznan University of Life Sciences, ul. Wojska Polskiego 48, 60-627 Poznań, Poland.
Joanna
J
Rychlik
D000327:Adsorption; D000388:Air; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004058:Diffusion; D006801:Humans; D007700:Kinetics; D008823:Micelles; D009928:Organ Specificity; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*; D013500:Surface Tension; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology*; D014867:Water
D008823:Micelles; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; D014867:Water
Adsorption dynamics; Catanionic mixtures; Diffusion coefficient; In vitro cytotoxicity; Micelle dissociation rate constant