Formyl Peptide receptor 1 expression is associated with tumor progression and survival in gastric cancer.
BACKGROUND
Formyl peptide receptor 1 (FPR1) as a regulator of innate inflammatory response has been implicated in tumor progression of gliomas. The purpose of the present study was to evaluate the prognostic significance and the ligand-receptor interaction of FPR1 in gastric cancer (GC).


METHODS
FPR1 was immunohistochemically-analyzed in tissue sections originating from 116 GC patients. Reverse transcription-polymerase chain reaction (RT-PCR) was used for the assessment of interaction between FPR1 and the FPR1 ligand annexin A1 (AnxA1) in GC cells.


RESULTS
High FPR1 expression was significantly associated with stage IV disease, submucosal invasion, serosal invasion, and clinical outcome of GC. Multivariate analysis showed that high FPR1 expression was an independent risk factor of poor overall survival in GC patients. FPR1 expression increased significantly when AnxA1 overexpression was present in GC cells. A positive feedback regulation of FPR1 was involved in the AnxA1-FPR1 signal transduction.


CONCLUSIONS
FPR1 expression may be used as a novel indicator to predict outcome in GC patients after gastrectomy.
Laboratory of Molecular and Cellular Toxicology, Graduate Institute of Toxicology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen Ai Road, Taipei 10051, Taiwan, R.O.C. kuominliang@ntu.edu.tw.
Tsu-Yao
TY
Cheng
Ming-Shiang
MS
Wu
Jaw-Town
JT
Lin
Ming-Tsan
MT
Lin
Chia-Tung
CT
Shun
Kuo-Tai
KT
Hua
Min-Liang
ML
Kuo
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D018450:Disease Progression; D005260:Female; D005743:Gastrectomy / Q000401:mortality; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D044042:Receptors, Formyl Peptide / Q000096:biosynthesis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology*
D014408:Biomarkers, Tumor; C469986:FPR1 protein, human; D044042:Receptors, Formyl Peptide
Formyl peptide receptor 1; annexin A1; gastric cancer; survival; tumor progression