Tributyltin distribution and producing androgenic activity in water, sediment, and fish muscle.
This study investigated the concentrations of Tributyltin (TBT) in water, sediment, and fish muscle samples taken from Kaohsiung Harbor and Kaoping River estuary, Taiwan. TBT concentrations in water and sediment samples ranged from less than 18.5 to 34.1 ng Sn L(-1) and from 2.44 to 29.7 ng Sn g(-1) weight per weight (w/w), respectively. Concentrations in the TBT-contaminated fish muscle samples ranged from 10.8 to 79.6 ng Sn g(-1) w/w. The TBT concentrations in fish muscle were higher than those in water and sediment samples. The fish muscle/water TBT bioconcentration factor (BCF) ranged from 590 to 3363 L kg(-1). Additionally, the water samples were assessed for androgenic activity with an MCF7-AR1 human breast cancer cell line. The androgenic activity ranged from 0.94 to 3.1 ng-dihydrotestosterone per litre water (ng-DHT L(-1)). Higher concentrations of TBT in water and sediment samples occurred in the dry season, but the androgenic activity had higher values in the rainy season.
a Department of Environmental Science and Occupational Safety and Hygiene , Tajen University , Enpu , Pingtung , Taiwan.
Meei-Fang
MF
Shue
Ting-Chien
TC
Chen
Luzvisminda M
LM
Bellotindos
Ming-Chun
MC
Lu
D000818:Animals; D013196:Dihydrotestosterone / Q000378:metabolism; D052244:Endocrine Disruptors / Q000633:toxicity; D004784:Environmental Monitoring; D005399:Fishes; D019015:Geologic Sediments / Q000032:analysis*; D006801:Humans; D061986:MCF-7 Cells / Q000187:drug effects; D018482:Muscle, Skeletal / Q000737:chemistry*; D013624:Taiwan; D014220:Trialkyltin Compounds / Q000032:analysis* / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000633:toxicity
D052244:Endocrine Disruptors; D014220:Trialkyltin Compounds; D014874:Water Pollutants, Chemical; D013196:Dihydrotestosterone; C011559:tributyltin
Androgenic activity; Megalaspis cordyla, organotins; Pennahia argentatus; Psenopsis anomala; anti‐fouling agent; bioconcentration factor (BCF), endocrine disrupting chemical, in vitro bioassay; tributyltin (TBT)