Caveolin-1 expression in odontogenic cysts and ameloblastomas.
OBJECTIVE
The aim of this study is to evaluate the caveolin-1 expression in a group of odontogenic cysts and tumors.


METHODS
In this cross-sectional study, the expression of caveolin-1 was evaluated immunohistochemically in 75 samples including 18 cases of dentigerous cyst, 18 odontogenic keratocysts, 3 orthokeratinized odontogenic cysts, 2 calcifying odontogenic cysts and 34 ameloblastomas (solid and unicystic).


RESULTS
Positive immunohistochemical reaction was found in 100% of odontogenic cysts and this was significantly more than both unicystic (65%) and solid (55%) ameloblastomas.


CONCLUSIONS
The present study showed the expression of caveolin-1 in all odontogenic cysts and more than ameloblastomas. The results suggested that absence of caveolin-1 might enhance aggressiveness of odontogenic lesions and could be a useful marker for distinguishing ameloblastomas from other odontogenic lesions.
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, SHIRAZ, IRAN.
Zohreh
Z
Jaafari-Ashkavandi
Soheil
S
Pardis
Maryam
M
Asadzadeh
Azadeh
A
Andisheh-Tadbir
Ali
A
Dehghani-Nazhvani
D000564:Ameloblastoma / Q000378:metabolism / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D051242:Caveolin 1 / Q000378:metabolism*; D003430:Cross-Sectional Studies; D006801:Humans; D007150:Immunohistochemistry; D007571:Jaw Diseases / Q000378:metabolism / Q000473:pathology*; D007573:Jaw Neoplasms / Q000378:metabolism / Q000473:pathology*; D009807:Odontogenic Cysts / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; C495540:CAV1 protein, human; D051242:Caveolin 1