Effect of atorvastatin on vascular endothelial function in moderately nicotine-dependent smokers.
We investigated the effect of atorvastatin on vascular endothelial function in moderately nicotine-dependent smokers. One hundred and sixty moderately nicotine-dependent smokers were randomly divided into the atorvastatin group (N = 80) and the control group (N = 80). Total cholesterol (TC), triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose levels, aspartate aminotransferase, total bilirubin, creatine phosphokinase, and brachial artery flow-mediated vasodilation function (FMD) were measured before and 12 months after atorvastatin treatment. After a 12-month atorvastatin therapy, the TC and LDL-C levels of patients were decreased significantly (P < 0.05) and the FMD of patients were improved significantly (P < 0.05). Compared with the control group, TC and LDL-C of the patients were significantly decreased (P < 0.05) and the FMD of the patients were significantly improved (P < 0.05). Atorvastatin may significantly improve endothelial function in moderately nicotine-dependent smokers.
Fuzhou General Hospital, Nanjing Command, PLA, Fuzhou, China.
X Z
XZ
Cao
Fuzhou General Hospital, Nanjing Command, PLA, Fuzhou, China.
Z R
ZR
Luo
Fuzhou General Hospital, Nanjing Command, PLA, Fuzhou, China.
H M
HM
Zhang
Fuzhou General Hospital, Nanjing Command, PLA, Fuzhou, China jinquancai@yeah.net.
J Q
JQ
Cai
D000328:Adult; D000069059:Atorvastatin; D008078:Cholesterol, LDL / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects*; D005260:Female; D006538:Heptanoic Acids / Q000008:administration & dosage*; D006801:Humans; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000378:metabolism; D011758:Pyrroles / Q000008:administration & dosage*; D014029:Tobacco Use Disorder / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D014280:Triglycerides / Q000097:blood; D014664:Vasodilation / Q000187:drug effects*
D008078:Cholesterol, LDL; D006538:Heptanoic Acids; D008055:Lipids; D008075:Lipoproteins, HDL; D011758:Pyrroles; D014280:Triglycerides; D009538:Nicotine; D000069059:Atorvastatin