The long and winding road of progress in the use of in vitro data for risk assessment purposes: From "carnation test" to integrated testing strategies.
This paper introduces the special issue on quantitative in vitro-in vivo extrapolations (QIVIVE). It highlights important issues in the development of in vitro toxicology towards its implementation in toxicological risk assessment.
Institute for Risk Assessment Sciences, Division of Toxicology, Utrecht University, PO Box 80.177, 3508 TD Utrecht, The Netherlands. Electronic address: b.blaauboer@uu.nl.
Bas J
BJ
Blaauboer
D000826:Animal Testing Alternatives; D000818:Animals; D001711:Biotransformation; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques / Q000639:trends; D008954:Models, Biological; D018570:Risk Assessment; D012307:Risk Factors; D049490:Systems Biology; D018675:Toxicity Tests / Q000379:methods* / Q000639:trends; D014116:Toxicology / Q000379:methods* / Q000639:trends
Biomarkers; In vitro toxicology; Quantitative in vitro-in vivo extrapolation