The Effects of Needling Fenglong (ST40) and Neiguan (PC6) on IL-17 of ApoE-Gene-Knockout Mice's Liver.
The aim of the present paper was to observe the effects of needling ST40 and PC6 on IL-17 of ApoE(-/-) mice with fatty liver. Forty male ApoE(-/-) mice were randomized into Needling-Acupoint Group, Simvastatin Intragastric Administration Group, Needling Nonacupoint Group, and Model Group. Each was fed with high fat diet for 8 weeks since 16 weeks of age; after 8 weeks of intervention, mice were sacrificed and tested for various examinations. Result showed that the body weight, TC, and serum IL-17 in Needling-Acupoint Group decreased. Compared with Model Group, the immunohistochemical expressions of IL-17 in liver tissue were significantly decreased among the other three groups. In conclusion, acupuncture was able to lower the expression of IL-17 level both in serum and liver tissue in ApoE(-/-) mice, which is helpful to reduce the inflammation and defers the progress from fatty liver to cirrhosis.
School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring Road, Chaoyang District, Beijing 100029, China.
Fu Yun
FY
Lee
Acupuncture and Moxibustion Department, The Third Hospital of Peking University, No. 49 North Garden Road, Haidian District, Beijing 100191, China.
Ze Jun
ZJ
Huo
School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring Road, Chaoyang District, Beijing 100029, China.
Li
0000-0003-3330-0934
L
Zhang
Acupuncture and Moxibustion Department, The Third Hospital of Peking University, No. 49 North Garden Road, Haidian District, Beijing 100191, China.
Jia
J
Guo
School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring Road, Chaoyang District, Beijing 100029, China.
Huan
H
Chen
School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring Road, Chaoyang District, Beijing 100029, China.
Tong
T
Liu
School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring Road, Chaoyang District, Beijing 100029, China.
Bo
0000-0001-9296-0452
B
Peng
School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring Road, Chaoyang District, Beijing 100029, China.
Pei Xin
PX
Hong
School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring Road, Chaoyang District, Beijing 100029, China.
Yuan Yuan
YY
Peng
School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring Road, Chaoyang District, Beijing 100029, China.
Yi Fan
YF
Fan
School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring Road, Chaoyang District, Beijing 100029, China.
Yu Pei
YP
Chen