Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population.
OBJECTIVE
To investigate the relationship between the interleukin 10 (IL10) gene single nucleotide polymorphisms (SNP) -1082 G/A (rs1800896), -819 T/C (rs1800871) and -592 A/C (rs1800872) and risk of type 2 diabetes mellitus in a Chinese population.


METHODS
This case-control study recruited patients with type 2 diabetes mellitus and healthy control subjects. Genotyping of the -1082 G/A (rs1800896), -819 T/C (rs1800871) and -592 A/C (rs1800872) SNPs was conducted and genotype frequencies were compared between the two groups.


RESULTS
The study recruited 364 patients with type 2 diabetes mellitus and 677 healthy controls. Patients carrying the -1082 GG genotype had a significantly increased risk of type 2 diabetes mellitus (adjusted odds ratio [OR] 1.57, 95% confidence interval [CI] 1.03, 2.68), as did those patients carrying the -592 AA genotype (adjusted OR 1.63, 95% CI 1.06, 2.53). Subjects carrying both the -1082 GA + GG and -592 AC + AA genotypes had a significantly increased risk of type 2 diabetes mellitus (adjusted OR 2.03, 95% CI 1.24, 3.15).


CONCLUSIONS
The SNPs -1082G/A and -592 A/C increased the risk for type 2 diabetes mellitus, and could be potential targets for screening for the early detection of the risk of type 2 diabetes mellitus.
Department of Endocrinology, First Affiliated Hospital of the People's Liberation Army, Beijing, China.
Hua
H
Bai
Department of Endocrinology, First Affiliated Hospital of the People's Liberation Army, Beijing, China.
Danqing
D
Jing
Department of Pathology, General Hospital of the People's Liberation Army, Beijing, China.
Aitao
A
Guo
Department of Endocrinology, First Affiliated Hospital of the People's Liberation Army, Beijing, China shinanyang677@126.com.
Shinan
S
Yin
D020121:5' Untranslated Regions; D000328:Adult; D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D014280:Triglycerides / Q000097:blood
D020121:5' Untranslated Regions; D001786:Blood Glucose; D008078:Cholesterol, LDL; C508609:IL10 protein, human; D014280:Triglycerides; D016753:Interleukin-10
   IL10 gene; Interleukin 10; polymorphism; predictive markers; type 2 diabetes mellitus