[Effect of epsilon-aminocaproic acid, cyclophosphamide and their combination on the growth of autochthonous sarcomas of mice induced by benzo(a)pyrene].
Antifibrinolytic drug epsilon-aminocaproic acid as a therapeutic form (5% solution in saline) was tested for antitumor activity in the autochthonous subcutaneous tumors of mice, induced by benzo (a) pyrene, in monotherapy mode (instead animals received drinking water) and in combination with cyclophosphamide, which was administered once intraperitoneally in the dose of 200 mg/kg. In the control groups, treated with drinking water and saline solution instead of water, there was no stabilization and reduction in tumor volume, while in the groups receiving epsilon-aminocaproic acid, cyclophosphamide and their combination statistically significantly in comparison with the control groups there was increased the proportion of tumors with not changed or reduced volume; epsilon-aminocaproic acid enhanced the antitumor effect of cyclophosphamide. The data obtained are for further study of the antitumor effect of epsilon-aminocaproic acid.
I V
IV
Anikin
M L
ML
Tyndyk
M A
MA
Zabezhinskiĭ
I G
IG
Popovich
V N
VN
Anisimov
G B
GB
Pliss
D015119:Aminocaproic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D001564:Benzo(a)pyrene; D002273:Carcinogens; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004354:Drug Screening Assays, Antitumor; D005260:Female; D051379:Mice; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D002273:Carcinogens; D001564:Benzo(a)pyrene; D003520:Cyclophosphamide; D015119:Aminocaproic Acid