Sensitivity and specificity of the World Health Organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro.
BACKGROUND
The clinical definition of severe dengue fever remains a challenge for researchers in hyperendemic areas like Brazil. The ability of the traditional (1997) as well as the revised (2009) World Health Organization (WHO) dengue case classification schemes to detect severe dengue cases was evaluated in 267 children admitted to hospital with laboratory-confirmed dengue.


RESULTS
Using the traditional scheme, 28.5% of patients could not be assigned to any category, while the revised scheme categorized all patients. Intensive therapeutic interventions were used as the reference standard to evaluate the ability of both the traditional and revised schemes to detect severe dengue cases. Analyses of the classified cases (n = 183) demonstrated that the revised scheme had better sensitivity (86.8%, P<0.001), while the traditional scheme had better specificity (93.4%, P<0.001) for the detection of severe forms of dengue.


CONCLUSIONS
This improved sensitivity of the revised scheme allows for better case capture and increased ICU admission, which may aid pediatricians in avoiding deaths due to severe dengue among children, but, in turn, it may also result in the misclassification of the patients' condition as severe, reflected in the observed lower positive predictive value (61.6%, P<0.001) when compared with the traditional scheme (82.6%, P<0.001). The inclusion of unusual dengue manifestations in the revised scheme has not shifted the emphasis from the most important aspects of dengue disease and the major factors contributing to fatality in this study: shock with consequent organ dysfunction.
Laboratório de Engenharia em Sistemas de Saúde, Programa de Engenharia Biomédica/COPPE/UFRJ, Rio de Janeiro, Brasil.
Gleicy A
GA
Macedo
Hospital Municipal Jesus (HMMJ) -SMSDC-RJ, Rio de Janeiro, Brasil.
Michelle Luiza C
ML
Gonin
Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
Sheila M
SM
Pone
Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
Oswaldo G
OG
Cruz
Laboratório de Engenharia em Sistemas de Saúde, Programa de Engenharia Biomédica/COPPE/UFRJ, Rio de Janeiro, Brasil.
Flávio F
FF
Nobre
Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
Patrícia
P
Brasil
D000293:Adolescent; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003422:Critical Care / Q000706:statistics & numerical data; D005260:Female; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012015:Reference Standards; D012680:Sensitivity and Specificity; D019595:Severe Dengue / Q000145:classification* / Q000175:diagnosis* / Q000453:epidemiology; D014944:World Health Organization