Serum lipids and lipoproteins in patients with psoriasis.
BACKGROUND
Psoriasis is a common chronic and recurrent inflammatory skin disorder characterized by hyperproliferation of keratinocytes and infiltration of T cells, monocytes/macrophages and neutrophils into dermal and epidermal layers of the skin. The prevalence of cardiovascular disorders in these patients is remarkably higher compared to normal individuals, which seems to be associated with the hyperlipidemia. This study was designed and conducted to investigate the serum lipid profile in psoriatic patients and its association with the severity of disease.


METHODS
This case-control study was performed on 50 plaque-type psoriasis patients and 50 healthy individuals as control, matched for age and sex. Blood samples were collected after 14 h fasting. Serum triglyceride, cholesterol and lipoproteins were assayed using the standard kit (made by Pars Azmon Co. Iran).


RESULTS
Certain parameters, including serum triglyceride, cholesterol, low density lipoprotein (LDL), and very low density lipoprotein (VLDL), were significantly higher in the case group compared to the controls (P < 0.001), while high density lipoprotein (HDL) was significantly lower in the former (P < 0.001). In addition, there was a significant relationship between severity of psoriasis and serum lipid profile.


CONCLUSIONS
The results have revealed the higher plasma level of lipids in psoriatic patients. This may elevate the risk of atherosclerosis, particularly cardiovascular disorders. Therefore, from the epidemiological point of view, screening psoriatic patients, particularly those with severe psoriasis, is recommended.
Departmen of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, Department of Medical Mycology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran. hajheydariz@yahoo.com.
Mehdi
M
Taheri Sarvtin
Departmen of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Mohammad Taghi
MT
Hedayati
Departmen of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Tahereh
T
Shokohi
Departmen of Dermatology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Zohreh
Z
HajHeydari
D000328:Adult; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D008055:Lipids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol