Rh(III)-catalyzed regioselective hydroarylation of alkynes via directed C-H functionalization of pyridines.
Rh(III)-catalyzed C-3 selective alkenylation of pyridine derivatives via hydroarylation of alkynes has been developed. The reaction shows high regioselectivity, high yield and good functional group tolerance, providing a convenient strategy for the synthesis of trisubstituted (pyridin-3-yl)alkenes.
Department of Chemistry, Zhejiang Univers ity, Hangzhou 310027, China. bfshi@zju.edu.cn.
Zhen-Chao
ZC
Qian
Jun
J
Zhou
Bo
B
Li
Fang
F
Hu
Bing-Feng
BF
Shi