Comparative activity of proline-containing dipeptide noopept and inhibitor of dipeptidyl peptidase-4 sitagliptin in a rat model of developing diabetes.
Developing diabetes was modeled on adult male Wistar rats by repeated intraperitoneal injections of streptozotocin in a subdiabetogenic dose of 30 mg/kg for 3 days. Proline-containing dipeptide drug Noopept or a standard diabetic drug dipeptidyl peptidase-4 inhibitor sitagliptin was administered per os in a dose of 5 mg/kg before each injection of the toxin and then for 16 days after streptozotocin course. In active control group, spontaneously increase glucose level and reduced tolerance to glucose load (1000 mg/kg intraperitoneally) were observed on the next day after the third administration of toxin. Basal glucose level decreased by day 16, but glucose tolerance remained impaired. Noopept normalized the basal blood glucose level and tolerance to glucose load on the next day after administration of streptozotocin. The effect of Noopept persisted to the end of the experiment. At early terms of the experiment, sitagliptin was somewhat superior to Noopept by the effect on baseline glucose level, but was inferior by the influence on glucose tolerance.. By the end of the experiment, Noopept significantly (by 2 times) surpassed sitagliptin by its effect on glucose tolerance.
V.V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia, rita.ostrovskaya@gmail.com.
R U
RU
Ostrovskaya
I V
IV
Ozerova
T A
TA
Gudascheva
I G
IG
Kapitsa
E A
EA
Ivanova
T A
TA
Voronina
S B
SB
Seredenin
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004151:Dipeptides / Q000737:chemistry / Q000627:therapeutic use*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000627:therapeutic use*; D004195:Disease Models, Animal; D011392:Proline / Q000737:chemistry*; D011719:Pyrazines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D000068900:Sitagliptin Phosphate; D014230:Triazoles / Q000627:therapeutic use*
D004151:Dipeptides; D054873:Dipeptidyl-Peptidase IV Inhibitors; D011719:Pyrazines; D014230:Triazoles; C103871:ethyl phenylacetyl-Pro-Gly; D011392:Proline; D000068900:Sitagliptin Phosphate