Evaluation of neonatal jaundice in the Makkah region.
The aims of this study were to detect the frequency at which the different types of neonatal jaundice occur in Makkah and to estimate the malondialdehyde (MDA) levels. This study included 239 neonates with neonatal jaundice, 20 anemic neonates and 21 healthy neonates. ABO incompatibility was observed in 31.6% of neonates with indirect hyperbilirubinemia, in 14.3% of those with early onset jaundice, in 9.5% of those with persistent jaundice, in 8.5% of those with physiological jaundice, in 5% of anemic neonates and in 12% of all neonates. glucose-6-phosphate dehydrogenase (G6PD) deficiency was observed in 10.5% of neonates with indirect hyperbilirubinemia, in 3.9% of those with physiological jaundice, in 11.1% of those with direct hyperbilirubinemia, in 12% of those with persistent jaundice, in 10% of anemic neonates and in 6.6% of all neonates. Rh incompatibility and polycythemia were found in 2.6% of neonates with indirect hyperbilirubinemia and in 0.4% of all neonates. In comparison to control group, MDA was significantly higher in all groups except for the anemic group. In conclusion, ABO incompatibility and G6PD deficiency frequently result in neonatal jaundice in Makkah, whereas Rh incompatibility and polycythemia are rare. The MDA level may serve as an indicator of oxidative stress.
Department of Pediatrics, Faculty of Medicine, Umm Al-Qura University, Makkah, K.S.A.
Abdulaziz
A
Alkhotani
Department of Clinical Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, K.S.A.
Essam Eldin Mohamed Nour
EE
Eldin
Department of Hematology and Immunology, Faculty of Medicine, Umm Al-Qura University, Makkah, K.S.A.
Amal
A
Zaghloul
Blood Bank, Ministry of Health, Makkah, K.S.A.
Shakil
S
Mujahid
D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D012529:Saudi Arabia / Q000453:epidemiology