Role of spiral artery Doppler to screen type 2 endometrial cancer cases.
OBJECTIVE
The purpose of this study was to determine the value of endometrial blood flow assessment in predicting type 2 endometrial carcinoma.


METHODS
Sixty-five consecutive post-menopoausal women who had vaginal bleeding were enrolled in the study. All subjects were directed to transvaginal sonography to determine endometrial blood flow and underwent endometrial biopsy. Doppler findings were analysed to predict endometrial pathology. Subjects with unsatisfactory Doppler analyses were excluded from the study.


RESULTS
Mean age of the study population was 50.1±6.9 years (42-73). Mean endometrial thickness was 10.1±2.9 mm (4-15 mm) and mean cancer antigen 125 (CA125) level was 20.1±17.4 U/mL (3-92). Histopathological evaluation revealed 14 cases of type 2 endometrial cancer and 18 cases of endometrial hyperplasia without atypia, while the other 33 cases had normal endometrial tissue. CA125 (Area under curve (AUC)=0.853, p=0.000), spiral artery resistance index (AUC=0.905, p=0.000), and spiral artery peak systolic velocity (AUC=0.822, p=0.000) were significant predictors for the type 2 endometrial cancer cases. Endometrial thickness did not significantly predict pathologic cases (p>0.05). Hyperplasia cases were not predicted by any of these diagnostic modalities (p>0.05).


CONCLUSIONS
In patients with postmenopausal bleeding, spiral artery Doppler ultrasound, could play a role in refining the diagnosis of type 2 endometrial carcinoma; however, its predictive value should be evaluated with further studies.
Department of Obstetrics and Gynecology, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.
Soner
S
Düzgüner
Department of Obstetrics and Gynecology, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.
Mehmet Burak
MB
Ozkan
Department of Obstetrics and Gynecology, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.
Tuncay
T
Küçüközkan
Department of Obstetrics and Gynecology, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.
Enis
E
Ozkaya
Department of Obstetrics and Gynecology, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.
Fadıl
F
Kara
Department of Obstetrics and Gynecology, Etlik Zübeyde Hanım Gynaecological Diseases Training and Research Hospital, Ankara, Turkey.
Ipek Nur
IN
Balın
Department of Obstetrics and Gynecology, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.
Vakkas
V
Korkmaz
Department of Obstetrics and Gynecology, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.
Mehmet Fatih
MF
Karslı
Department of Obstetrics and Gynecology, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.
Burak
B
Gültekin
Type 2 endometrial cancer; post-menopausal woman; spiral artery Doppler