Stressful life events and depressive symptoms among symptomatic long QT syndrome patients.
We examined whether long QT syndrome status moderates the association between stressful life events and depressive symptoms. Participants were 562 (n= 246 symptomatic) long QT syndrome mutation carriers. Depressive symptoms were measured with a modified version of the Beck's Depression Inventory. There was an interaction between long QT syndrome status and stressful life events on depressive symptoms. In the symptomatic long QT syndrome patients, stressful life events were associated with depressive symptoms (B= 0.24, p< 0.001). In the asymptomatic long QT syndrome mutation carriers, this association was 62.5 percent weaker (B= 0.09, p= 0.057). Compared to asymptomatic long QT syndrome mutation carriers, symptomatic long QT syndrome patients are more sensitive to the depressive effects of stressful life events.
IBS, Psychology, University of Helsinki, Finland taina.hintsa@helsinki.fi.
Taina
T
Hintsa
IBS, Psychology, University of Helsinki, Finland.
Markus
M
Jokela
National Institute for Health and Welfare, Finland.
Marko
M
Elovainio
IBS, Psychology, University of Helsinki, Finland.
Ilmari
I
Määttänen
Department of Cardiology, Helsinki University Central Hospital, University of Helsinki, Finland.
Heikki
H
Swan
IBS, Psychology, University of Helsinki, Finland Helsinki Collegium for Advanced Studies, University of Helsinki, Finland.
Mirka
M
Hintsanen
Department of Cardiology, Helsinki University Central Hospital, University of Helsinki, Finland.
Lauri
L
Toivonen
Department of Medicine, University of Helsinki, Finland.
Kimmo
K
Kontula
IBS, Psychology, University of Helsinki, Finland.
Liisa
L
Keltikangas-Järvinen
D000293:Adolescent; D000328:Adult; D000368:Aged; D003863:Depression / Q000523:psychology*; D005260:Female; D006801:Humans; D008016:Life Change Events; D008133:Long QT Syndrome / Q000235:genetics / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D013315:Stress, Psychological / Q000523:psychology*; D055815:Young Adult
arrhythmic risk; depressive mood; long QT syndrome; stressful life events