Interfacial metal coordination in engineered protein and peptide assemblies.
Metal ions are frequently found in natural protein-protein interfaces, where they stabilize quaternary or supramolecular protein structures, mediate transient protein-protein interactions, and serve as catalytic centers. Paralleling these natural roles, coordination chemistry of metal ions is being increasingly utilized in creative ways toward engineering and controlling the assembly of functional supramolecular peptide and protein architectures. Here we provide a brief overview of this emerging branch of metalloprotein/peptide engineering and highlight a few select examples from the recent literature that best capture the diversity and future potential of approaches that are being developed.
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, United States.
Pamela A
PA
Sontz
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, United States.
Woon Ju
WJ
Song
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, United States. Electronic address: tezcan@ucsd.edu.
F Akif
FA
Tezcan
D020134:Catalytic Domain; D008667:Metalloproteins / Q000737:chemistry / Q000378:metabolism*; D008670:Metals / Q000737:chemistry / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D015202:Protein Engineering
D008667:Metalloproteins; D008670:Metals; D010455:Peptides