Neurofibromatosis 1 vasculopathy manifesting as a peripheral aneurysm in an adolescent.
Arterial vasculopathy is a well-recognized but uncommon manifestation of neurofibromatosis type 1 (NF-1). It can manifest as stenoses, aneurysms or arteriovenous malformations. NF-1 vasculopathy typically involves the aorta, visceral arteries or carotid-vertebral circulation. Aortic and visceral vasculopathy typically presents as stenotic lesions, while aneurysms have been reported primarily in the subclavian/vertebral arteries. Aneurysms of the peripheral/extremity arteries are an extremely rare complication of NF-1 that may present as a mass or spontaneous rupture. We present the case of a teenage boy with an arm mass secondary to an aneurysm. We hope this case will increase recognition of the variable clinical manifestations of NF-1 vasculopathy among radiologists.
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd., St. Louis, MO, 63110, USA, farmakiss@mir.wustl.edu.
Shannon G
SG
Farmakis
Min
M
Han
Frances
F
White
Geetika
G
Khanna
D000293:Adolescent; D000783:Aneurysm / Q000209:etiology* / Q000473:pathology*; D003937:Diagnosis, Differential; D004550:Elbow / Q000098:blood supply / Q000473:pathology; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000473:pathology*; D058729:Peripheral Arterial Disease / Q000209:etiology* / Q000473:pathology*