The magnitude of nocebo effects in pain: a meta-analysis.
The investigation of nocebo effects is evolving, and a few literature reviews have emerged, although so far without quantifying such effects. This meta-analysis investigated nocebo effects in pain. We searched the databases PubMed, EMBASE, Scopus, and the Cochrane Controlled Trial Register with the term "nocebo." Only studies that investigated nocebo effects as the effects that followed the administration of an inert treatment along with verbal suggestions of symptom worsening and that included a no-treatment control condition were eligible. Ten studies fulfilled the selection criteria. The effect sizes were calculated using Cohen's d and Hedges' g. The overall magnitude of the nocebo effect was moderate to large (lowest g=0.62 [0.24-1.01] and highest g=1.03 [0.63-1.43]) and highly variable (range of g=-0.43 to 4.05). The magnitudes and range of effect sizes was similar to those of placebo effects (d=0.81) in mechanistic studies. In studies in which nocebo effects were induced by a combination of verbal suggestions and conditioning, the effect size was larger (lowest g=0.76 [0.39-1.14] and highest g=1.17 [0.52-1.81]) than in studies in which nocebo effects were induced by verbal suggestions alone (lowest g=0.64 [-0.25 to 1.53] and highest g=0.87 [0.40-1.34]). These findings are similar to those in the placebo literature. As the magnitude of the nocebo effect is variable and sometimes large, this meta-analysis demonstrates the importance of minimizing nocebo effects in clinical practice.
Department of Psychology and Behavioural Sciences, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark National Center for Complementary and Alternative Medicine (NCCAM), National Institute of Mental Health (NIMH), and Clinical Center, Department of Bioethics, National Institutes of Health, Bethesda, MD, USA Department of Psychology, University of Turin, National Institute of Neuroscience (INN), Turin, Italy Division of Neuroscience, Department of Oral and Maxillofacial Surgery, University of Florida, Gainesville, FL, USA.
Gitte Laue
GL
Petersen
Nanna Brix
NB
Finnerup
Luana
L
Colloca
Martina
M
Amanzio
Donald D
DD
Price
Troels Staehelin
TS
Jensen
Lene
L
Vase
D006801:Humans; D006930:Hyperalgesia / Q000175:diagnosis* / Q000503:physiopathology; D064786:Nocebo Effect; D010146:Pain / Q000175:diagnosis* / Q000503:physiopathology; D010147:Pain Measurement
Conditioning; Magnitude; Nocebo; Pain; Placebo; Verbal suggestion