Potential matrix metalloproteinase inhibitors from edible marine algae: a review.
Matrix metalloproteinases are endopeptidases which belong to the group of metalloproteinases that contribute for the extra-cellular matrix degradation, and several tissue remodeling processes. An imbalance in the regulation of these endopeptidases eventually leads to several severe pathological complications like cancers, cardiac, cartilage, and neurological related diseases. Hence inhibitory substances of metalloproteinases (MMPIs) could prove beneficial in the management of above specified pathological conditions. The available synthetic MMPIs that have been reported until now have few shortcomings and thus many of them could not make to the final clinical trials. Hence a growing interest among researchers on screening of MMPIs from different natural resources is evident and especially natural products from marine origin. As there has been an unparalleled contribution of several biologically active compounds from marine resources that have shown profound applications in nutraceuticals, cosmeceuticals, and pharmaceuticals, we have attempted to discuss the various MMPIs from edible sea-weeds.
Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea.
Noel Vinay
NV
Thomas
Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea.
Panchanathan
P
Manivasagan
Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea; Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea. Electronic address: sknkim@pknu.ac.kr.
Se-Kwon
SK
Kim
D000818:Animals; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors / Q000494:pharmacology*; D059808:Polyphenols / Q000494:pharmacology; D011134:Polysaccharides / Q000494:pharmacology; D012624:Seaweed; D013634:Tannins / Q000494:pharmacology
D061965:Matrix Metalloproteinase Inhibitors; D059808:Polyphenols; D011134:Polysaccharides; D013634:Tannins
Cancer; Inflammation; Marine algae; Matrix metalloproteinases; Metastasis; Phlorotannins; Sulfated polysaccharides