Molecular regulation of macrophages in unleashing cancer-related inflammation.
It is unclear how tumor-associated macrophages (TAMs) contribute to the initiation of oncogenesis and how they are regulated at the molecular level. By using a lineage-specific deletion strategy, we found that heat shock protein 90kDa β (Grp94), member 1 (HSP90B1), a master chaperone for Toll-like receptors and integrins also known as GP96, critically endows TAMs with the ability to promote genotoxic stress and colitis-associated colon cancer.
Department of Microbiology and Immunology; Hollings Cancer Center; Medical University of South Carolina; Charleston, SC USA.
Feng
F
Hong
Department of Microbiology and Immunology; Hollings Cancer Center; Medical University of South Carolina; Charleston, SC USA.
Bill X
BX
Wu
Department of Microbiology and Immunology; Hollings Cancer Center; Medical University of South Carolina; Charleston, SC USA.
Zihai
Z
Li
TLR; colon cancer; gp96; grp94; inflammation; tumor-associated macrophages