Pluronics suppress association of low-density lipoproteins inducing atherogenesis.
We studied the effect of pluronics P85, L61, and F68 with different hydrophilic-lipophilic characteristics on association of LDL. It was found that pluronics with pronounced hydrophobic properties (P85 and L61) in concentrations close to or surpassing the critical concentration of micelle formation inhibited LDL association, while hydrophilic pluronic F68 in all concentrations had no effect on LDL association.
Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia, inat-science@yandex.ru.
A A
AA
Mel'nichenko
D V
DV
Aksenov
O M
OM
Panasenko
A A
AA
Yaroslavov
I A
IA
Sobenin
A N
AN
Orehov
D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000188:drug therapy; D002340:Carotid Artery Diseases / Q000097:blood / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry*
D008077:Lipoproteins, LDL; D020442:Poloxamer