Effect of antioxidants supplementation on aging and longevity.
If aging is due to or contributed by free radical reactions, as postulated by the free radical theory of aging, lifespan of organisms should be extended by administration of exogenous antioxidants. This paper reviews data on model organisms concerning the effects of exogenous antioxidants (antioxidant vitamins, lipoic acid, coenzyme Q, melatonin, resveratrol, curcumin, other polyphenols, and synthetic antioxidants including antioxidant nanoparticles) on the lifespan of model organisms. Mechanisms of effects of antioxidants, often due to indirect antioxidant action or to action not related to the antioxidant properties of the compounds administered, are discussed. The legitimacy of antioxidant supplementation in human is considered.
Department of Biochemistry and Cell Biology, University of Rzeszów, Zelwerowicza Street 4, 35-601 Rzeszów, Poland.
Izabela
0000-0001-9035-6833
I
Sadowska-Bartosz
Department of Biochemistry and Cell Biology, University of Rzeszów, Zelwerowicza Street 4, 35-601 Rzeszów, Poland ; Department of Molecular Biophysics, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland.
Grzegorz
G
Bartosz
D000375:Aging / Q000187:drug effects* / Q000502:physiology*; D000975:Antioxidants / Q000008:administration & dosage*; D019587:Dietary Supplements; D019317:Evidence-Based Medicine; D006801:Humans; D008136:Longevity / Q000187:drug effects* / Q000502:physiology*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D016896:Treatment Outcome
D000975:Antioxidants; D017382:Reactive Oxygen Species