Toward integrated molecular diagnostic system (i MDx): principles and applications.
Integrated molecular diagnostic systems ( iMDx), which are automated, sensitive, specific, user-friendly, robust, rapid, easy-to-use, and portable, can revolutionize future medicine. This review will first focus on the components of sample extraction, preservation, and filtration necessary for all point-of-care devices to include for practical use. Subsequently, we will look for low-powered and precise methods for both sample amplification and signal transduction, going in-depth to the details behind their principles. The final field of total device integration and its application to the clinical field will also be addressed to discuss the practicality for future patient care. We envision that microfluidic systems hold the potential to breakthrough the number of problems brought into the field of medical diagnosis today.
Seung-Min
SM
Park
Andrew F
AF
Sabour
Jun Ho
JH
Son
Sang Hun
SH
Lee
Luke P
LP
Lee
D019033:Delivery of Health Care, Integrated; D004867:Equipment Design; D006801:Humans; D046210:Microfluidic Analytical Techniques; D025202:Molecular Diagnostic Techniques; D019095:Point-of-Care Systems