Hyperthyroidism associated with obesity-related glomerulopathy-like pathologic features.
Thyroid dysfunction is related to many kidney diseases. We herein present the case of a 39-year-old woman who exhibited obesity-related glomerulopathy-like pathologic features in combination with hyperthyroidism. She displayed hyperthyroidism in spite of receiving anti-thyroid drug treatment, with massive proteinuria (4.5 g/gCr). A renal biopsy demonstrated glomerular hypertrophy (average diameter, 280 μm) and an increased number of capillary vessels, both of which are compatible with a diagnosis of obesity-related glomerulopathy. Following thyroidectomy, the proteinuria gradually decreased in association with an improvement in hyperphagia and normalization of the thyroid function. Obesity-related nephropathy associated with hyperthyroidism is very rare. In this report, we discuss the relationship between hyperthyroidism and obesity-related glomerulopathy-like pathologic features.
Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Japan.
Homare
H
Shimohata
Hiroshi
H
Maruyama
Yujiro
Y
Ogawa
Masaki
M
Kobayashi
D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis / Q000209:etiology*; D006984:Hypertrophy; D007674:Kidney Diseases / Q000150:complications* / Q000175:diagnosis; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008854:Microscopy, Electron; D009765:Obesity / Q000150:complications* / Q000175:diagnosis