[Epidemiology of bone and joint disease - the present and future - . Molecular epidemiology of osteoporosis].
Osteoporosis is a common skeletal disease characterized by low bone mineral density (BMD) and microarchitectural deterioration of bone tissue. Osteoporosis increases susceptibility to fracture. Over the last 10 years, genome-wide association studies (GWAS) have identified the single-nucleotide polymorphisms (SNPs) associated with low BMD, osteoporosis and osteoporotic fractures. These SNPs were mapped close to or within the genes, such as Wnt- and RANKL-related genes. In the future, molecular epidemiology of osteoporosis may provide novel candidates for therapeutic targets.
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Japan.
Tomohiko
T
Urano
D000818:Animals; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D010024:Osteoporosis / Q000453:epidemiology* / Q000235:genetics*; D058866:Osteoporotic Fractures / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015398:Signal Transduction