Ibuprofen dependence: a case report.
Ibuprofen is currently widely prescribed and has not been reported to produce dependence. We report the case of a 17-year old patient who presented many positive psychic symptoms related to a pharmacological dependence. During the treatment, she adjusted herself posology as she developed withdrawal symptoms. Pharmacological evidences (effect on COX-1 and COX-2, FAAH and PPARs) allow us to formulate hypotheses explaining this effect.
Center for Evaluation and Information on Pharmacodependence, Clinical Pharmacology Department, University Hospital, Nantes, France.
F
F
Etcheverrigaray
Addictology and Psychiatry Department, University Hospital, Nantes, France.
M
M
Grall-Bronnec
Addictology and Psychiatry Department, University Hospital, Nantes, France.
M-C
MC
Blanchet
Center for Evaluation and Information on Pharmacodependence, Clinical Pharmacology Department, University Hospital, Nantes, France.
P
P
Jolliet
Center for Evaluation and Information on Pharmacodependence, Clinical Pharmacology Department, University Hospital, Nantes, France.
C
C
Victorri-Vigneau
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D019966:Substance-Related Disorders / Q000209:etiology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen