Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180.
The medicinal properties of fungi of the genus Pleurotus have attracted great interest due to their therapeutic properties. Polysaccharides synthesized by Pleurotus, including the β-glucans are considered the main responsible for its therapeutic properties. This study aimed to evaluate the efficacy of polysaccharidic fractions extracted from mycelial biomass of Pleurotus ostreatus DSM 1833 in inhibiting the development of Ehrlich Tumor (ET) and Sarcoma 180 (S-180). FC, FI and FII fractions provided 60.6, 76.5 and 73.6% of ET inhibition, respectively (mean value of about 70%) while FS, FIII-1 and FIII-2 showed no inhibition against ET. FII and FIII-2 resulted in 85.6 and 93.6% (mean value of about 90%) while FIII-1, FC and FS resulted in 54.1 and 0%, respectively, of S-180 inhibition. The yields of the fractions FS, FI, FII, FIII-1 and FIII-2 obtained from P. ostreatus mycelial biomass were 11.6, 1.3, 0.4, 0.65 and 0.35%, respectively. FII fraction (30mg/kg) apparently had no toxic effect on healthy animals, since no difference between the body weights of animals in substance control (SC) and negative control (NC) groups was observed.
Master Science in Health and Environment, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
Jean Mary
JM
Facchini
Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
Endi Pricila
EP
Alves
Department of Pharmacy, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
Charlise
C
Aguilera
Master Science in Health and Environment, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Department of Pharmacy, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil. Electronic address: rgern@univille.br.
Regina Maria Miranda
RM
Gern
Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Department of Pharmacy, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
Marcia Luciane Lange
ML
Silveira
Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Master Science in Process Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
Elisabeth
E
Wisbeck
Master Science in Health and Environment, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Master Science in Process Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
Sandra Aparecida
SA
Furlan
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018533:Biomass; D001835:Body Weight / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D005591:Chemical Fractionation; D025282:Mycelium / Q000737:chemistry; D020076:Pleurotus / Q000737:chemistry*; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000473:pathology; D047368:Tumor Burden / Q000187:drug effects
D000970:Antineoplastic Agents; D011134:Polysaccharides
Ehrlich Tumor; Pleurotus ostreatus; Polysaccharides; Sarcoma 180