Does long intestinal tube splinting aggravate intestinal adhesions?
OBJECTIVE
Long intestinal tube splinting (LITS) is useful for clinically reducing the recurrence of adhesive small bowel obstruction (ASBO). However, a controversy exists whether LITS aggravates intestinal adhesions. This study evaluated the postoperative effects of LITS relative to simple enterolysis on intestinal adhesions in an experimental porcine model.


METHODS
A porcine model (n = 24) of dense intestinal adhesion was established by abrading the ileal wall with sterile P240 sandpaper. Enterolysis was performed on postoperative day 14. Animals were randomly divided into a group that underwent enterolysis only (control; n = 12) and those who underwent LITS as well as enterolysis (LITS; n = 12). The long intestinal tube was removed on post-LITS day 14, after abdominal radiography. All animals were euthanized on postenterolysis day 28 for assessment of intestinal adhesions using a semiquantitative macroscopic grading scale, hematoxylin-eosin histology, and hydroxyproline assay.


RESULTS
Prior to enterolysis, the experimentally induced intestinal adhesions of the two groups were similar in extent and severity. On postenterolysis day 28 the LITS and control groups were comparable with regard to adhesion loop length (p = .440), macroscopic adhesion severity (p = .820), serosal fibrosis grading (p = .450), and hydroxyproline content of the adhesion ileal segment (p = .630).


CONCLUSIONS
Placement of the long intestinal tube did not aggravate intestinal adhesions over that of simple enterolysis in this intestinal adhesion porcine model.
Department of General Surgery, Jinling Hospital, Medicine School of Nanjing University , Nanjing, Jiangsu Province , China.
Min
M
Li
Gang
G
Wang
Bo
B
Zhou
Xianfeng
X
Xia
Ning
N
Li
D000818:Animals; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D005260:Female; D006909:Hydroxyproline / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007415:Intestinal Obstruction / Q000517:prevention & control / Q000601:surgery*; D011897:Random Allocation; D012008:Recurrence; D013552:Swine; D000267:Tissue Adhesions / Q000209:etiology* / Q000378:metabolism
D006909:Hydroxyproline