A concise colorimetric and fluorimetric probe for sarin related threats designed via the "covalent-assembly" approach.
A turn-on signal from zero background allows sensitive detection of a weak signal and is highly desired. The "covalent-assembly" probe design principle is powerful in this regard. Herein, we report an embodiment of this principle (NA570) for detection of Sarin related threats, based on a phenylogous Vilsmeier-Haack reaction. NA570 bears a concise molecular construct, exhibits a colorimetric and a fluorimetric signal, and has potential for real applications.
State Key Laboratory of Bioreactor Engineering, ‡Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
Zuhai
Z
Lei
Youjun
Y
Yang
D002619:Chemical Warfare Agents / Q000737:chemistry / Q000633:toxicity*; D003124:Colorimetry / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry*; D012524:Sarin / Q000737:chemistry / Q000633:toxicity*; D013050:Spectrometry, Fluorescence
D002619:Chemical Warfare Agents; D005456:Fluorescent Dyes; D012524:Sarin