Targeting mitochondria as therapeutic strategy for metabolic disorders.
Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario. Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer. Finally, novel mechanisms of regulation of mitochondrial function are discussed, which open new scenarios for mitochondria targeting.
Dipartimento di Scienze Biomediche Avanzate, Università Federico II, Via Pansini 5, 80131 Napoli, Italy.
Daniela
0000-0002-1599-4509
D
Sorriento
Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Via Salvador Allende, 84081 Baronissi, Italy.
Antonietta Valeria
AV
Pascale
Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Via Salvador Allende, 84081 Baronissi, Italy.
Rosa
R
Finelli
Dipartimento di Scienze Biomediche Avanzate, Università Federico II, Via Pansini 5, 80131 Napoli, Italy.
Anna Lisa
AL
Carillo
Dipartimento di Scienze Biomediche Avanzate, Università Federico II, Via Pansini 5, 80131 Napoli, Italy.
Roberto
R
Annunziata
Dipartimento di Scienze Biomediche Avanzate, Università Federico II, Via Pansini 5, 80131 Napoli, Italy.
Bruno
0000-0002-0701-6449
B
Trimarco
Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Via Salvador Allende, 84081 Baronissi, Italy ; IRCCS Multimedica, Via Fantoli 16/15, 20138 Milano, Italy.
Guido
G
Iaccarino
D004272:DNA, Mitochondrial / Q000235:genetics; D006801:Humans; D008659:Metabolic Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D009154:Mutation; D010085:Oxidative Phosphorylation; D017382:Reactive Oxygen Species / Q000378:metabolism
D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species