Adaptogenic effects of dihydroquercetin-chitosan composition during modeling of acute hypoxia.
The course of preventive oral treatment with a dihydroquercetin-chitosan composition produced a strong antihypoxic effect under conditions of experimental hypobaric hypoxia (arbitrary altitude 12,000 m). The lactate/pyruvate ratio in composition-receiving rats was much lower than in hypoxic animals (by 83%), but higher than in intact specimens (by 29%). The composition of chitosan and dihydroquercetin also possessed a strong antioxidant activity.
Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia.
E I
EI
Murach
I A
IA
Baranov
E I
EI
Erlykina
A S
AS
Koryagin
A E
AE
Mochalova
L A
LA
Smirnova
D000208:Acute Disease; D000818:Animals; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
D048271:Chitosan; D011794:Quercetin; C003377:taxifolin