Effect of galectin-1 on apoptosis of CD4(+) lymphocytes differentiated in vitro towards regulatory T cells.
We studied the effect of galectin-1 on apoptosis of CD4(+) lymphocytes intact and in vitro differentiated towards regulatory T cells. An increase in the content of apoptotic CD4(+) lymphocytes was observed after exposure of intact cells with 15 ng/ml galectin-1 and after exposure of regulatory T cells with 10 and 15 ng/ml galectin-1. Apoptosis of regulatory T cells induced by galectin-1 was accompanied by an increase in the content of proapoptotic protein Bad.
Department of Pathophysiology, Siberian State Medical University, the Ministry of Health Care and Social Development, Tomsk, Russia, yakushinavd@mail.ru.
V D
VD
Yakushina
O A
OA
Vasil'eva
V V
VV
Novitskii
N V
NV
Andreeva
E G
EG
Starikova
L A
LA
Tashireva
T S
TS
Prokhorenko
A P
AP
Zima
N V
NV
Ryazantseva
D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D002454:Cell Differentiation; D002478:Cells, Cultured; D037483:Galectin 1 / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*; D051025:bcl-Associated Death Protein / Q000378:metabolism*
C494819:BAD protein, human; D037483:Galectin 1; C445499:LGALS1 protein, human; D051025:bcl-Associated Death Protein