Liquid chromatography/mass spectrometry to study oxidative degradation of environmentally relevant pharmaceuticals by electrochemistry and ozonation.
In this work, the potential of electrochemical oxidation as a tool for the rapid prediction of transformation products in water appearing after ozonation is investigated. These two approaches were compared by choosing the two environmentally relevant model compounds diclofenac and metoprolol and comparison of their transformation products after electrochemical oxidation and treatment with ozone. Within these two approaches, certain similarities were observed in the resulting chromatograms: Six transformation products of the electrochemical oxidation of metoprolol were also detected in the ozone samples. For diclofenac two transformation products matched. Additionally, five of the electrochemically generated oxidation products were reported in literature to occur after water treatment processes. The application of a boron-doped diamond working electrode for electrochemical oxidation allowed the generation of hydroxyl radicals, which was shown by spin trapping experiments with p-chlorobenzoic acid. This allowed the generation of certain transformation products previously not obtained by electrochemical oxidation. Concluding, the hyphenation of electrochemistry with liquid chromatography and mass spectrometry offers a useful tool in transformation studies.
Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstraße 30, 48149 Münster, Germany.
Helene
H
Faber
Universität Duisburg-Essen, Instrumentelle Analytische Chemie, Universitätsstraße 4, 45141 Essen, Germany.
Holger
H
Lutze
Universität Duisburg-Essen, Instrumentelle Analytische Chemie, Universitätsstraße 4, 45141 Essen, Germany.
Pablo Lores
PL
Lareo
Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstraße 30, 48149 Münster, Germany.
Lisa
L
Frensemeier
Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstraße 30, 48149 Münster, Germany.
Martin
M
Vogel
Universität Duisburg-Essen, Instrumentelle Analytische Chemie, Universitätsstraße 4, 45141 Essen, Germany.
Torsten C
TC
Schmidt
Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstraße 30, 48149 Münster, Germany. Electronic address: uk@uni-muenster.de.
Uwe
U
Karst
D002853:Chromatography, Liquid / Q000379:methods*; D004008:Diclofenac / Q000737:chemistry; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D008790:Metoprolol / Q000737:chemistry; D010084:Oxidation-Reduction; D010126:Ozone / Q000737:chemistry*; D053719:Tandem Mass Spectrometry / Q000379:methods*; D018508:Water Purification / Q000379:methods
D004008:Diclofenac; D010126:Ozone; D008790:Metoprolol
Diclofenac; Electrochemistry; LC/MS; Metoprolol; Ozonation; Transformation products