Caffeine intake may modulate inflammation markers in trained rats.
Caffeine is presented in many commercial products and has been proven to induce ergogenic effects in exercise, mainly related to redox status homeostasis, inflammation and oxidative stress-related adaptation mechanisms. However, most studies have mainly focused on muscle adaptations, and the role of caffeine in different tissues during exercise training has not been fully described. The aim of this study was therefore, to analyze the effects of chronic caffeine intake and exercise training on liver mitochondria functioning and plasma inflammation markers. Rats were divided into control, control/caffeine, exercise, and exercise/caffeine groups. Exercise groups underwent four weeks of swimming training and caffeine groups were supplemented with 6 mg/kg/day. Liver mitochondrial swelling and complex I activity, and plasma myeloperoxidase (MPO) and acetylcholinesterase (AChE) activities were measured. An anti-inflammatory effect of exercise was evidenced by reduced plasma MPO activity. Additionally, caffeine intake alone and combined with exercise decreased the plasma AChE and MPO activities. The per se anti-inflammatory effect of caffeine intake should be highlighted considering its widespread use as an ergogenic aid. Therefore, caffeine seems to interfere on exercise-induced adaptations and could also be used in different exercise-related health treatments.
Departamento de Química, Centro de Ciências Naturais e Exatas (CCNE), Universidade Federal de Santa Maria (UFSM), 97105-900 Santa Maria, Brazil. romulo1604@hotmail.com.
Rômulo Pillon
RP
Barcelos
Departamento de Química, Centro de Ciências Naturais e Exatas (CCNE), Universidade Federal de Santa Maria (UFSM), 97105-900 Santa Maria, Brazil. mrfighera@yahoo.com.br.
Mauren Assis
MA
Souza
Departamento de Química, Centro de Ciências Naturais e Exatas (CCNE), Universidade Federal de Santa Maria (UFSM), 97105-900 Santa Maria, Brazil. guipiresa@yahoo.com.br.
Guilherme Pires
GP
Amaral
Departamento de Química, Centro de Ciências Naturais e Exatas (CCNE), Universidade Federal de Santa Maria (UFSM), 97105-900 Santa Maria, Brazil. silviotstefanello@hotmail.com.
Silvio Terra
ST
Stefanello
Departamento de Química, Centro de Ciências Naturais e Exatas (CCNE), Universidade Federal de Santa Maria (UFSM), 97105-900 Santa Maria, Brazil. mrfighera@yahoo.com.br.
Guilherme
G
Bresciani
Laboratório de Bioquímica do Exercício (BioEx), Centro de Educação Física e Desportos, Universidade Federal de Santa Maria (UFSM), 97105-900 Santa Maria, Brazil. mrfighera@yahoo.com.br.
Michele Rechia
MR
Fighera
Departamento de Química, Centro de Ciências Naturais e Exatas (CCNE), Universidade Federal de Santa Maria (UFSM), 97105-900 Santa Maria, Brazil. mrfighera@yahoo.com.br.
Félix Alexandre Antunes
FA
Soares
Departamento de Química, Centro de Ciências Naturais e Exatas (CCNE), Universidade Federal de Santa Maria (UFSM), 97105-900 Santa Maria, Brazil. nvbarbosa@yahoo.com.br.
Nilda
N
de Vargas Barbosa
D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D002110:Caffeine / Q000494:pharmacology*; D007249:Inflammation / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008564:Membrane Potentials; D008930:Mitochondria, Liver / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D009195:Peroxidase / Q000097:blood; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species
D015415:Biomarkers; D017382:Reactive Oxygen Species; D002110:Caffeine; D009195:Peroxidase; D000110:Acetylcholinesterase