Effects of gonadoliberin analogue triptorelin on the pituitary-testicular complex in neonatal rats.
Triptorelin, a synthetic analogue of neurohormone gonadoliberin (gonadotropin-releasing hormone, GnRH) administered daily to rats on postnatal days 5-7 suppressed the expression of GnRH receptor in the pituitary gland, but did not change functioning of the pituitary-testicular complex. Administration of triptorelin on postnatal days 12-14 (i.e. during the formation of pulsatile pattern of GnRH secretion and increasing levels of its mRNA receptor in the pituitary gland) had no effect on receptor expression, but increased the levels of luteinizing hormone mRNA in the pituitary gland and the weight of testes. At that time, blood levels of testosterone were lowered, which indicated disturbed pulsatile pattern of GnRH secretion.
Department of Physiology, Novosibirsk State University, Novosibirsk, Russia, dygalo@bionet.nsc.ru.
N N
NN
Dygalo
T V
TV
Shemenkova
T S
TS
Kalinina
G T
GT
Shishkina
D000818:Animals; D000831:Animals, Newborn; D037201:Follicle Stimulating Hormone, beta Subunit / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D037101:Luteinizing Hormone, beta Subunit / Q000235:genetics / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011966:Receptors, LHRH / Q000235:genetics / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D013739:Testosterone / Q000097:blood; D017329:Triptorelin Pamoate / Q000494:pharmacology*
D037201:Follicle Stimulating Hormone, beta Subunit; D037101:Luteinizing Hormone, beta Subunit; D012333:RNA, Messenger; D011966:Receptors, LHRH; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone