Multivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children.
We examined factors affecting the immunogenicity of trivalent inactivated influenza vaccination (TIV) in children using the antibody titres of children participating in a Hong Kong community-based study. Antibody titres of strains included in the 2009-2010 northern hemisphere TIV [seasonal A(H1N1), seasonal A(H3N2) and B (Victoria lineage)] and those not included in the TIV [2009 pandemic A(H1N1) and B (Yamagata lineage)] were measured by haemagglutination inhibition immediately before and 1 month after vaccination. Multivariate regression models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titres following vaccination. Statistically significant rises in geometric mean antibody titres were observed against all strains, with a wide variety of standard deviations and correlations in rises observed, with the influenza type B antibodies showing more variability than the type A antibodies. The dynamics of antibody titres after vaccination can be used in more complex models of antibody dynamics in populations.
Division of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
G
G
Freeman
Department of Ecology and Evolutionary Biology,Princeton University,Princeton, NJ,USA.
S
S
Ng
Division of Public Health Laboratory Sciences, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
R A P M
RA
Perera
Division of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
V J
VJ
Fang
Division of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
D K M
DK
Ip
Division of Community Medicine and Public Health Practice, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
G M
GM
Leung
Division of Public Health Laboratory Sciences, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
J S M
JS
Peiris
Division of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
B J
BJ
Cowling
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006723:Hong Kong; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology; D009981:Influenza B virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D015999:Multivariate Analysis; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated
Immunization (vaccination); influenza; serology; statistics