Supramolecular self-assembled aggregates formed by pentacosa-10,12-diynyl amidomethyl-β-cyclodextrin.
Mono[6-deoxy-6-(pentacosa-10,12-diynyl amidomethyl)]-β-cyclodextrin was successfully synthesized by reacting mono-6-amino-6-deoxy-β-cyclodextrin with N-hydroxysuccinimide ester of 10,12-pentacosadiynoic acid in DMF. The modified β-cyclodextrin self-assembled and aggregated to form a worm-like supramolecular structure, and the novel supramolecular aggregates were studied using 2D nuclear magnetic resonance spectroscopy, X-ray powder diffraction, thermogravimetry, and electron microscopy. Interestingly, the synthesized pentacosa-10,12-diynyl amidomethyl-β-cyclodextrin formed columnar type self-aggregates and it was clearly differentiated from cage-like structure of native β-cyclodextrin.
Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center (BMIC) & Institute for Ubiquitous Information Technology and Applications (CBRU), Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
Eunae
E
Cho
Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center (BMIC) & Institute for Ubiquitous Information Technology and Applications (CBRU), Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
Hwanhee
H
Kim
School of Chemical & Biological Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-744, Republic of Korea.
Jee Eun
JE
Yang
Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea.
Bong-Hyun
BH
Jun
School of Chemical & Biological Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-744, Republic of Korea.
Seung R
SR
Paik
Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center (BMIC) & Institute for Ubiquitous Information Technology and Applications (CBRU), Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea. Electronic address: shjung@konkuk.ac.kr.
Seunho
S
Jung
D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis* / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry*
D005231:Fatty Acids, Unsaturated; D046911:Macromolecular Substances; D047392:beta-Cyclodextrins
10,12-Pentacosadiynoic acid; Self-assembly; Supramolecular structure; β-Cyclodextrin