Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise.
Obesity-related hypertension is associated with increased activity of the renin-angiotensin-aldosterone system (RAAS), increasing arterial stiffness. Aerobic exercise decreases pulse wave velocity (PWV), therefore a treatment option for hypertension and obesity. Assess RAAS activity and PWV before and after 4 weeks of aerobic training in unmedicated, pre-to-stage-1 hypertensives. Ten obese subjects (52±3.2 years, body mass index=33.5±1.4) performed 30 min of aerobic exercise on a treadmill 3 days per week at 65% of peak oxygen consumption (VO2peak). Descriptive characteristics, systolic and diastolic blood pressure (SBP and DBP), PWV, and a blood draw was performed at baseline, following the 4-week control and training interventions. No differences in descriptive characteristics during the control period were observed, however, a significant decrease in plasma aldosterone (ALDO) (255.4±75 to 215.8±66 pg ml(-1), P=0.001), SBP (140±12 to 136±10.4 mm Hg; P=0.02), DBP (89±4.2 to 85±6.3 mm Hg; P=0.03) and central PWV (11.2±0.6 to 9.8±0.8 m s(-1); P=0.04) was shown pre-to-post exercise training. Four weeks of moderate-intensity aerobic training in obese, hypertensives decreases plasma ALDO independently of body weight and is significantly correlated to decreases in PWV reductions.
Vascular Biology and Autonomic Studies Laboratory, Department of Health Leisure and Exercise Science, Appalachian State University, Boone, NC, USA.
S R
SR
Collier
Center for the Study of Sex Differences in Health, Aging and Disease, Department of Medicine, Georgetown University Medical Center, Washington DC, USA.
K
K
Sandberg
Vascular Biology and Autonomic Studies Laboratory, Department of Health Leisure and Exercise Science, Appalachian State University, Boone, NC, USA.
A M
AM
Moody
Department of Medicine, Upstate Medical University, Syracuse, NY, USA.
V
V
Frechette
Vascular Biology and Autonomic Studies Laboratory, Department of Health Leisure and Exercise Science, Appalachian State University, Boone, NC, USA.
C D
CD
Curry
Center for the Study of Sex Differences in Health, Aging and Disease, Department of Medicine, Georgetown University Medical Center, Washington DC, USA.
H
H
Ji
Department of Medicine, Upstate Medical University, Syracuse, NY, USA.
R
R
Gowdar
Department of Medicine, Upstate Medical University, Syracuse, NY, USA.
D
D
Chaudhuri
Department of Movement, University of Rome 'Foro Italico', Human and Health Sciences, Rome, Italy.
M
M
Meucci
D000450:Aldosterone / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015536:Down-Regulation; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D010101:Oxygen Consumption; D058246:Prehypertension / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D013997:Time Factors; D016896:Treatment Outcome; D059289:Vascular Stiffness
D015415:Biomarkers; D000450:Aldosterone