[Effect of formula of removing both phlegm and blood stasis in improving hemorheology and blood fat of mini-swine with coronary heart disease of phlegm-stasis cementation syndrome].
OBJECTIVE
To observe effect of formula of removing both phlegm and blood stasis (TYTZ) in improving hemorheology and blood fat of mini-swine with coronary heart disease of phlegm-stasis cementation syndrome.


METHODS
Thirty-six Chinese mini-swine were randomly divided to six groups: the normal control group, the model group, the Shujiangzhi group and TYTZ groups with doses of 2.0, 1.0 and 0.5 g x kg(-1), with six mice in each group. Except for the normal control group, all of other groups were fed with high-fat diet for 2 weeks. Interventional balloons are adopted to injure their left anterior descending artery endothelium. After the operation, they were fed with high-fat diet for 8 weeks to prepare the coronary heart disease model of phlegm-stasis cementation syndrome. In the 8th week after the operation and administration, the changes in hemorheological parameters, serum lipid level, myocardial ischemia level and range were observed.


RESULTS
Compared with the normal control group, the model group showed significant increase in serum TC, TG, LDL-C and VLDL-C levels (P < 0.01), whole blood viscosity under the shear rate of 5 s (-1) and 60 s (-1) (P < 0.01), and myocardial ischemia degree and range (P < 0.01). Compared with the model group, TYTZ groups revealed significant decrease in myocardial ischemia degree and range (P < 0.01), serum TC, TG, LDL-C and VLDL-C levels (P < 0.05 or P < 0.01) and whole blood viscosity under the shear rate of 5 s(-1) and 60 s(-1) (P < 0.05).


CONCLUSIONS
TYTZ could improve the abnormal hemorheology in Chinese mini-swine with coronary heart disease of phlegm-stasis cementation syndrome, and regulate serum lipid, with a certain efficacy for coronary heart disease of phlegm-stasis cementation syndrome.
Cheng-Ren
CR
Lin
Lei
L
Li
Jian-Xun
JX
Ren
Min
M
Wang
Jun-Mei
JM
Li
Hong-Hai
HH
Li
Zheng-Yan
ZY
Ge
Long
L
Jin
Ming-Jiang
MJ
Yao
Jian-Xun
JX
Liu
D000818:Animals; D003327:Coronary Disease / Q000097:blood / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D018056:Hemorheology; D008055:Lipids / Q000097:blood*; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D009092:Mucous Membrane / Q000378:metabolism*; D013552:Swine; D013556:Swine, Miniature
D008055:Lipids