Bilateral motor tasks involve more brain regions and higher neural activation than unilateral tasks: an fMRI study.
Movements that involve simultaneous coordination of muscles of the right and left lower limbs form a large part of our daily activities (e.g., standing, rising from a chair). This study used functional magnetic resonance imaging to determine which brain areas are used to control coordinated lower-limb movements, specifically comparing regions that are activated during bilateral exertions to those performed unilaterally. Plantarflexor exertions were produced at a target force level of 15% of the participants' maximum voluntary contraction, in three conditions, with their right (dominant) foot, with their left foot, and with both feet simultaneously. A voxel-wise analysis determined which regions were active in the bilateral, but not in the unilateral conditions. In addition, a region of interest (ROI) approach was used to determine differences in the percent signal change (PSC) between the conditions within motor areas. The voxel-wise analysis showed a large number of regions (cortical, subcortical, and cerebellar) that were active during the bilateral condition, but not during either unilateral condition. The ROI analysis showed several motor regions with higher activation in the bilateral condition than unilateral conditions; further, the magnitude of bilateral PSC was more than the sum of the two unilateral conditions in several of these regions. We postulate that the greater levels of activation during bilateral exertions may arise from interhemispheric inhibition, as well as from the greater need for motor coordination (e.g., synchronizing the two limbs to activate together) and visual processing (e.g., monitoring of two visual stimuli).
Department of Physical Therapy, University of British Columbia, 212-2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Jeremy W
JW
Noble
Janice J
JJ
Eng
Lara A
LA
Boyd
D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply*; D001931:Brain Mapping; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005121:Extremities / Q000294:innervation; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009068:Movement / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D011597:Psychomotor Performance; D011930:Reaction Time / Q000502:physiology; D055815:Young Adult
D010100:Oxygen