Th17 cells are associated with the Th1/Th2‑cell balance during Echinococcus multilocularis infection.
The present study investigated the immunopathological effect of Echinococcus multilocularis (Em) using cytokine detection. Expression of the T‑helper (Th) 17‑cytokine, interleukin 17 (IL‑17), was observed using immunohistochemical staining, and levels of cytokines, including IL‑17, transforming growth factor β1 (TGF‑β1), IL‑6, interferon γ (IFN‑γ) and IL‑4, were assessed using ELISA at different stages of infection. IL‑17 expression occurred in hepatic cells at 1 month post‑infection, reached a maximum at 3 months post‑infection and then decreased gradually. Compared with the uninfected control, levels of the cytokines IL‑17, TGF‑β1, IL‑6, IFN‑γ and IL‑4 exhibited different dynamic patterns when infected with Em. In the immune response during the whole infection period, Th17 cells play an important role by secreting IL‑17, which may be involved in the Th1/Th2‑cell balance during the immune response. Th17 cells are associated with immunopathology in Em infection.
State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
Xiumin
X
Ma
State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
Liang
L
Wang
State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
Hui
H
Zhao
State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
Nannan
N
Pang
State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
Fengbo
F
Zhang
State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
Tao
T
Jiang
State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
Xuelei
X
Liu
State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
Wulamu
W
Mamuti
State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
Hao
H
Wen
State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
Jianbing
J
Ding
D000818:Animals; D004443:Echinococcosis / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D048210:Echinococcus multilocularis / Q000276:immunology* / Q000502:physiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000097:blood; D020381:Interleukin-17 / Q000097:blood / Q000378:metabolism*; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D051379:Mice; D008807:Mice, Inbred BALB C; D018417:Th1 Cells / Q000166:cytology* / Q000276:immunology; D058504:Th17 Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000166:cytology* / Q000276:immunology; D053773:Transforming Growth Factor beta1 / Q000097:blood
D020381:Interleukin-17; D015850:Interleukin-6; D053773:Transforming Growth Factor beta1; D015847:Interleukin-4; D007371:Interferon-gamma