Acute traumatic coagulopathy: clinical characterization and mechanistic investigation.
Trauma remains the leading cause of death and morbidity worldwide and bleeding is the primary reason for this mortality. Over the past 11 years there has been a paradigm shift in our understanding of coagulopathy after trauma. Specifically its incidence, biological drivers, clinical sequelae have been elucidated. From this understanding a concurrent change in resuscitation practices has occurred. This manuscript will review the history of resuscitation after injury, the discovery and clinical and biological characterization of acute traumatic coagulopathy and the changes in resuscitation practices aimed at combating coagulopathy and inflammatory perturbation after trauma. Finally it will discuss the ongoing state of the science and suggest topics for continued biological and clinical study.
Department of Surgery San Francisco General Hospital, The University of California San Francisco, San Francisco, CA, USA. Electronic address: mcohen@sfghsurg.ucsf.edu.
Mitchell Jay
MJ
Cohen
D000818:Animals; D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D006470:Hemorrhage / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D011486:Protein C / Q000378:metabolism; D012151:Resuscitation / Q000266:history / Q000379:methods*; D014947:Wounds and Injuries / Q000097:blood* / Q000150:complications* / Q000378:metabolism / Q000628:therapy
D011486:Protein C
Bleeding; Coagulation; Coagulopathy; Protein C; Resuscitation; Trauma