Comparative study of the effects of free bound and carrier protein angiotensin II in experimental hypoglycemia and hyperglycemia.
Experimental hypoglycemia and hyperglycemia eliminated the differences in the regulatory functions of free angiotensin II and its complexes with carrier proteins (transport protein BSA and neurospecific protein S100b) in rats. Under these conditions, free and protein-bound angiotensin II primarily suppressed operant drinking behavior and reduced the hypertensive and tachyarrhythmic effects in comparison with control rats. These changes were most pronounced during acute hyperglycemia. We hypothesized that complexes of angiotensin II with functionally different proteins are differentially and simultaneously involved in not only compensation of behavioral and hemodynamic disturbances during acute and/or chronic hypoglycemia and hyperglycemia, but also their transformation into pathological processes mediated by the so-called metabolic memory mechanisms.
Laboratory for Physiology of Motivations, P. K. Anokhin Research Institute of Normal Physiology Russian Academy of Medical Sciences, Moscow, Russia, stolpygo@mail.ru.
S M
SM
Tolpygo
E I
EI
Pevtsova
B B
BB
Shoibonov
A V
AV
Kotov
D000804:Angiotensin II / Q000008:administration & dosage / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure; D004327:Drinking Behavior; D006339:Heart Rate; D006943:Hyperglycemia / Q000378:metabolism / Q000503:physiopathology*; D007003:Hypoglycemia / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D017208:Rats, Wistar; D064568:S100 Calcium Binding Protein beta Subunit / Q000008:administration & dosage; D012710:Serum Albumin, Bovine / Q000008:administration & dosage; D013894:Thirst
D064568:S100 Calcium Binding Protein beta Subunit; C579158:S100b protein, rat; D000804:Angiotensin II; D012710:Serum Albumin, Bovine