Involvement of P2Y(2,4) receptors in the regulation of myocardial contractility in growing rats.
Experiments with R2Y receptor blockers allowed identification of R2Y subtypes mediating the inhibitory effects of uridine triphosphate on myocardial contractility. In 100-day-old animals, the myocardial inotropic response to the administration of uridine triphosphate was mediated by R2Y2 receptors. R2Y4 receptors took part in the realization of negative inotropic response to uridine triphosphate in all age groups, but the most pronounced effects of this substance on myocardial contractility were found in 100-day-old rats. It was found that R2Y receptor blockers PPADS and reagent blue-2 affect amplitude-time parameters of myocardial contractility in rats of various ages.
Department of Anatomy, Physiology, and Human Health Protection, Kazan' (Volga Region) Federal University, Kazan, Russia.
T A
TA
Anikina
I N
IN
Anisimova
A A
AA
Zverev
F G
FG
Sitdikov
T L
TL
Zefirov
D000818:Animals; D009200:Myocardial Contraction / Q000502:physiology*; D051381:Rats; D018048:Receptors, Purinergic P2 / Q000502:physiology*; D058473:Receptors, Purinergic P2Y2 / Q000502:physiology*
D018048:Receptors, Purinergic P2; D058473:Receptors, Purinergic P2Y2; C104749:purinoceptor P2Y4