[Optimization of preparation technology of LIUWEI cataplasm, a kind of Zhuang national herbs].
OBJECTIVE
To optimize preparation process of liuwei cataplasm, a Zhuang folk medical herb popularly applied as a kind of rheumatism, rheumatoid drug in Guangxi Zhuang Autonomous Region.


METHODS
Orthogonal design test was employed to optimise matrix proportion and molding technology of liuwei cataplasma with glossiness, adhesive power, matrix residue, skin following and repeatedly exposing as indexes.


RESULTS
Optimum matrix ratio of PANA, pressure sensitive adhesive, CNC-Na, gelatin, dihydroxyaluminium aminoacetate and glycerol was 0.5:1.0:0.4:0.1:0.3:3.0. Optimized parameters of technology were as follows: stiring speed 600 r/min, refining temperature 60 degrees C and drug loading of Liuwei extract 13.04%.


CONCLUSIONS
Optimized liuwei cataplasm has a good adhesive power, exipcients and glossiness, meanwhile drug loading is large and no skin residue. The process is simple, stable and viable.
Cai-Hong
CH
Xue
Yuan
Y
Luo
Jian-Qin
JQ
Liang
D000268:Adhesiveness; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004339:Drug Compounding; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005780:Gelatin / Q000008:administration & dosage; D005990:Glycerol / Q000008:administration & dosage; D008516:Medicine, Chinese Traditional; D009824:Ointments; D010946:Plants, Medicinal / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D009824:Ointments; D005780:Gelatin; D002266:Carboxymethylcellulose Sodium; D005990:Glycerol