The correlation between the expression of differentiated embryo-chondrocyte expressed gene l and oral squamous cell carcinoma.
BACKGROUND
This study aims to explore the correlation between expression of differentiated embryo-chondrocyte expressed gene l (DEC1) and oral squamous cell carcinoma (OSCC), which could provide the reference for treatment and prognosis assessment of OSCC.


METHODS
The expression of DEC1 in tissues from 56 primary OSCC patients and 20 normal oral mucosa samples were detected using real-time polymerase chain reaction and immunohistochemical methods, respectively.


RESULTS
The results showed that the positive expression rate of DEC1 in the OSCC group was significantly higher than that in the normal group (P <0.05); further, the expression of DEC1 in different OSCC groups was statistically significant (P <0.05). The expression of DEC1 in the 1-year recurrence OSCC group was significantly higher than other groups. The expression of DEC1 in the 3-years no recurrence OSCC group was the lowest.


CONCLUSIONS
The expression of DEC1 was associated with the incidence of OSCC and there was a negative correlation between the expression of DEC1 and the prognosis of OSCC.
Jingmin
J
You
Lu
L
Lin
Qiong
Q
Liu
Tengfei
T
Zhu
Kun
K
Xia
Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central-South University, Changsha 410008, China. tongsus@163.com.
Tong
T
Su
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D025521:Tumor Suppressor Proteins / Q000032:analysis / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; C403671:DELEC1 protein, human; D025521:Tumor Suppressor Proteins