Solvent free selective dehydrogenation of indolic and carbazolic molecules with an iridium pincer catalyst.
A previously known iridium POCOP pincer catalyst was found to selectively dehydrogenate the heterocyclic portion of several indolic and carbazolic molecules. These molecules were found to have an "activity window" (172-178 °C) upon which only the heterocyclic ring underwent dehydrogenation. All reactions were run solvent free, yields for selected substrates were excellent, and the products were isolated by either distillation or alumina plug filtration.
Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall Honolulu, HI 96822, USA. dbrayton@hawaii.edu.
Daniel F
DF
Brayton
Craig M
CM
Jensen
D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008401:Gas Chromatography-Mass Spectrometry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure
D002227:Carbazoles; D007211:Indoles; D007495:Iridium