Scoring systems predict the prognosis of acute-on-chronic hepatitis B liver failure: an evidence-based review.
Acute-on-chronic hepatitis B liver failure is a devastating condition that is associated with mortality rates of over 50% and is consequent to acute exacerbation of chronic hepatitis B in patients with previously diagnosed or undiagnosed chronic liver disease. Liver transplantation is the definitive treatment to lower mortality rate, but there is a great imbalance between donation and potential recipients. An early and accurate prognostic system based on the integration of laboratory indicators, clinical events and some mathematic logistic equations is needed to optimize treatment for patients. As parts of the scoring systems, the MELD was the most common and the donor-MELD was the most innovative for patients on the waiting list for liver transplantation. This review aims to highlight the various features and prognostic capabilities of these scoring systems.
Department of Infection and Liver Diseases, Liver Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Fa-Ling
FL
Wu
Ke-Qing
KQ
Shi
Yong-Ping
YP
Chen
Martin
M
Braddock
Hai
H
Zou
Ming-Hua
MH
Zheng
D065290:Acute-On-Chronic Liver Failure / Q000175:diagnosis* / Q000601:surgery / Q000821:virology; D003661:Decision Support Techniques; D019317:Evidence-Based Medicine; D019694:Hepatitis B, Chronic / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D016031:Liver Transplantation; D016015:Logistic Models; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014850:Waiting Lists
Child-Turcotte-Pugh score; King’s College Criteria; acute-on-chronic hepatitis B liver failure; artificial neural network; donor-MELD; liver transplantation; model for end-stage liver disease; prognosis; regression scoring models; scoring systems; sequential organ failure assessment