Clinical outcome of pancreas transplantation from marginal donors in Japan.
In Japan, absolute shortage of donors still continues even after the law allowing organ transplantation from deceased donors came into force in 1997. With the passage of the waiting period after registration for pancreas transplantation (PTx), both deaths and serious cases of diabetic complications necessitating withdrawal of the registration have undoubtedly increased. Therefore, so-called "marginal donor" (MD) has been considered as a potential solution for shortage of donors in Japan. The aim of the present study is to evaluate feasibility of MD in terms of post-PTx outcomes using data from Japan Organ Transplantation Network. A total of 148 PTx were performed from deceased donors in Japan from 2000 to 2012. MD was defined as follows: (1) >45 years old; (2) hemodynamically unstable at harvest using a high-dose dopamine or more than 2 vasopressors; or (3) non-heart-beating status. Postoperative outcomes after PTx were compared between the MD group and the non-MD group. Among the 148 PTx donors, 108 donors (73.0%) satisfied the criteria of MD. Early graft loss of pancreas graft during 3 months post-transplant was observed in 15 patients (10.1%), and the marginality (MD vs non-MD) was not significantly correlated with the early loss of pancreas graft. The overall patient survival of the MD group (1, 3, 5 years: 94.7%, 94.7%, 94.7%) was not significantly different from that of the non-MD group (1, 3, 5 years: 95.0%, 95.0%, 95.0%). Pancreas graft survival in the MD group (1, 3, 5 years: 80.9%, 73.2%, 66.0%) seemed to be slightly lower than that in the non-MD group (1, 3, 5 years: 92.5%, 85.2%, 77.4%), but no statistically significant differences were found between the 2 groups. These results suggest the feasibility of the use of MD for PTx.
Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
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Tomimaru
Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan; Department of Complementary & Alternative Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan; The Japan Registry of Pancreas Transplantation, Japan; The Japan Society for Pancreas and Islet Transplantation, Suita, Osaka, Japan. Electronic address: juki@cam.med.osaka-u.ac.jp.
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Ito
Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
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Kawamoto
Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
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Hama
Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
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Wada
Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
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Kobayashi
Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
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Eguchi
Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
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Tanemura
Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
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Mori
Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
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Doki
Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan. Electronic address: hnagano@gesurg.med.osaka-u.ac.jp.
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Nagano
D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D014019:Tissue Donors; D016896:Treatment Outcome