Mild thiamine deficiency and chronic ethanol consumption modulate acetylcholinesterase activity change and spatial memory performance in a water maze task.
Chronic thiamine deficiency may be responsible for pathologic changes in the brains of alcoholics, and subclinical episodes of this vitamin deficiency may cause cumulative brain damage. In the present work, the chronic effects of ethanol and its association to a mild thiamine deficiency episode (subclinical model) on neocortical and hippocampal acetylcholinesterase activity were assessed along with their possible association to spatial cognitive dysfunction. The results indicate that in the beginning of the neurodegenerative process, before the appearance of brain lesions, chronic ethanol consumption reverses the effects of mild thiamine deficiency on both spatial cognitive performance and acetylcholinesterase activity without having significant effects on any morphometric parameter.
Departamento de Análises Clínicas e Toxicológicas - Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-010, Brazil.
Ieda
I
de Fátima Oliveira-Silva
Programa de Pós-graduação em Neurociências, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-010, Brazil.
Silvia R Castanheira
SRC
Pereira
Departamento de Análises Clínicas e Toxicológicas - Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-010, Brazil.
Paula A
PA
Fernandes
Programa de Pós-graduação em Neurociências, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-010, Brazil.
Andrea F
AF
Ribeiro
Departamento de Ciências Fisiológicas/Centro Biomédico-Laboratório de Neurobiologia Molecular e Comportamental, Universidade Federal do Espírito Santo, Vitória, 29043-910, Brazil.
Rita G W
RGW
Pires
Programa de Pós-graduação em Neurociências, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-010, Brazil. angelamr@icb.ufmg.br.|Departamento de Bioquímica e Imunologia, Laboratório de Neurociências Comportamental e Molecular, LaNeC, Faculdade de Filosofia e Ciências Humanas, FaFiCH, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-010, Brazil. angelamr@icb.ufmg.br.
Angela Maria
AM
Ribeiro
D000110:Acetylcholinesterase / Q000378:metabolism*; D000437:Alcoholism / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D018782:Maze Learning; D019579:Neocortex / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D065852:Spatial Memory; D013832:Thiamine Deficiency / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology
D000110:Acetylcholinesterase