Intramolecular arylation of benzimidazoles via Pd(II)/Cu(I) catalyzed cross-dehydrogenative coupling.
Electron poor benzimidazole substrates were arylated via an intramolecular cross-dehydrogenative coupling (CDC) reaction. These CDC reactions were catalyzed by a Pd(II)/Cu(I) catalyst system, capable of producing moderate yields on a large library of substrates. The substrate scope consisted of tethered arene-benzimidazoles that upon coupling, produced a fused polycyclic motif.
Department of Chemistry, University of Rhode Island, Kingston, RI 02881, USA.
Kyle C
KC
Pereira
Department of Chemistry, University of Rhode Island, Kingston, RI 02881, USA.
Ashley L
AL
Porter
Department of Chemistry, University of Rhode Island, Kingston, RI 02881, USA.
Brenton
B
Deboef
Biaryl; Cross-dehydrogenative coupling; Dual catalysis; Oxidative Coupling; Palladium