Biophotonic ring resonator for ultrasensitive detection of DMMP as a simulant for organophosphorus agents.
Combining photonic integrated circuits with a biologically based sensing approach has the ability to provide a new generation of portable and low-cost sensor devices with a high specificity and sensitivity for a number of applications in environmental monitoring, defense, and homeland security. We report herein on the specific biosensing under continuous air flow of DMMP, which is commonly used as a simulant and a precursor for the synthesis of Sarin. The proposed technology is based on the selective recognition of the targeted DMMP molecule by specifically modified proteins immobilized on photonic structures. The response of the biophotonic structures shows a high stability and accuracy over 3 months, allowing for the detection in diluted air of DMMP at concentration as low as 35 μg/m(3) (6.8 ppb) in less than 15 min. The performance of the developed technology satisfies most current homeland and military security requirements.
Nanomatériaux pour les Systèmes Sous Sollicitations Extrêmes (NS3E), French-German Research Institute of Saint-Louis , UMR 3208 CNRS/ISL/UDS, 68301 Saint-Louis, France.
Karine
K
Bonnot
Francisco
F
Cuesta-Soto
Manuel
M
Rodrigo
Antonio
A
Varriale
Nuria
N
Sanchez
Sabato
S
D'Auria
Denis
D
Spitzer
Francisco
F
Lopez-Royo
D051337:Chemical Terrorism; D002619:Chemical Warfare Agents / Q000737:chemistry*; D004784:Environmental Monitoring; D008838:Microcomputers; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012524:Sarin / Q000138:chemical synthesis*
D002619:Chemical Warfare Agents; D009943:Organophosphorus Compounds; C031116:dimethyl methylphosphonate; D012524:Sarin