Pseudoangiosarcomatous squamous cell carcinoma developing on a burn scar: a case report and review of the literature.
Pseudoangiosarcomatous squamous cell carcinoma, also known as pseudovascular, pseudovascular adenoid and pseudoangiomatous squamous cell carcinoma, is an exceedingly rare, aggressive variant of cutaneous squamous cell carcinoma with extreme acantholysis resulting in angiosarcoma-like areas. Histologically, a pseudoangiosarcomatous pattern includes complex anastomosing channels and spaces lined with neoplastic cells. The neoplastic cells exhibit cytokeratin and vimentin positivity but yield negative results with CD31 and CD34. This case report describes pseudoangiosarcomatous squamous cell carcinoma developing on a burn scar on the ankle. In this report, we emphasize the importance of establishing a diagnosis with histological and immunohistochemical examination, and we review the described incidence of the age and sites with the prognosis for the treatment of pseudoangiosarcomatous squamous cell carcinoma of the skin.
Department of Plastic and Reconstructive Surgery, Hallym University Sacred Heart Hospital, Anyangsi, Republic of Korea.
Sung Hoon
SH
Koh
Institute of Burn, Reconstructive Plastic Surgery, Bestian Seoul Hospital, Seoul, Republic of Korea. Electronic address: sjoh46@nate.com.
Suk Joon
SJ
Oh
Institute of Burn, Reconstructive Plastic Surgery, Bestian Seoul Hospital, Seoul, Republic of Korea.
Huan
H
Chun
Institute of Burn, Reconstructive Plastic Surgery, Bestian Seoul Hospital, Seoul, Republic of Korea.
Seon Gyu
SG
Kim
D000368:Aged; D000842:Ankle; D002056:Burns / Q000150:complications; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002921:Cicatrix / Q000209:etiology / Q000473:pathology*; D005260:Female; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D012878:Skin Neoplasms / Q000473:pathology*
Artificial dermis; Burn scar; Pseudoangiosarcomatous; Skin transplantation; Squamous cell carcinoma