Response of smooth bronchial musculature in bronchoconstrictor substances in newborn with lung atelectasis at the respiratory distress syndrome (RDS).
OBJECTIVE
Role of the atelectasis (hypoxia) in the respiratory system of the live and exited newborn (250 up to 3000 g. of body weight), which has died due to different causes was studied in this work.


METHODS
Response of tracheal rings to dopamine, serotonine and ethanol in the different molar concentrations (dopamine: 0.05 mg/ml, 0.5 mg/ml, 5 mg/ml; serotonine (5-HT): 10(-4), 10(-3), 10(-2), 10(-1) mol/dm3; ethanol: 0.2 ml, 0.5 ml, 1.0 ml; 96%) was followed up. Study of the smooth tracheal musculature tone (STM) was elaborated in 16 tracheal preparations taken following the newborn death due to different causes.


RESULTS
Based on functional researches of tracheal isolated preparations, it was ascertained as follows: atelectasis (cases born with lung hypoxia) has changed the response of STM to dopamine, serotonine and ethanol in a significant manner (p < 0.01) in comparison to cases of controlling group, which has died due to lung inflammatory processes (e.g. pneumonia, bronchopneumonia, cerebral hemorrhage), which have also caused significant response (p < 0.05).


CONCLUSIONS
Results suggest that exited cases from lung atelectasis and cases of controlling group reacts to above mentioned substances by causing significant constrictor action of tracheobronchial system.
Lirim
L
Mustafa
Pëllumb
P
Islami
Nora
N
Shabani
Adelina
A
Jashanica
Hilmi
H
Islami
D001980:Bronchi; D016084:Bronchoconstriction; D016022:Case-Control Studies; D002492:Central Nervous System Depressants / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D000860:Hypoxia / Q000473:pathology; D007231:Infant, Newborn; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D001261:Pulmonary Atelectasis / Q000473:pathology*; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology*; D012701:Serotonin / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology
D002492:Central Nervous System Depressants; D017366:Serotonin Receptor Agonists; D013566:Sympathomimetics; D012701:Serotonin; D000431:Ethanol; D004298:Dopamine