Meta-analysis of the effects of endoscopy with narrow band imaging in detecting dysplasia in Barrett's esophagus.
Narrow band imaging (NBI) is a real-time imaging technique. The aim of this meta-analysis was to estimate the sensitivity, specificity, and diagnostic accuracy on the role of NBI in the detection and characterization of specialized intestinal metaplasia (SIM), high-grade dysplasia (HGD) in the Barrett's esophagus. We identified studies by performing a literature search of Medline, EMBASE, and the Cochrane Library databases up to May 2013. We performed data analysis using Meta-DiSc (version 1.4) software. To assess study quality and potential for bias, we used the Quality Assessment of Diagnostic Accuracy Studies-2 tool (QUADAS-2). Overall, seven eligible studies including over 3988 lesions of 502 patients were retrieved. The results showed that endoscopic diagnosis of dysplasia performed using NBI has a high diagnostic performance, with an area under the summary receiver operating characteristic (SROC) curve near 0.90 both in HGD lesions and SIM lesions. We also found that NBI has a sensitive and specificity of 0.91 (95% confidence interval [CI] = 0.86-0.94) and 0.85 (95% CI = 0.76-0.92) on a per-patient element, and 0.97 (95% CI = 0.95-0.98) and 0.64 (95% CI = 0.59-0.68) on a per-lesion element for SIM diagnosis, respectively. The pooled per-patient sensitivity and specificity for identifying HGD are 0.91 (95% CI = 0.75-0.98) and 0.95 (95% CI = 0.91-0.97). The pooled per-lesion sensitivity and specificity for identifying HGD are 0.69 (95% CI = 0.63-0.74) and 0.90 (95% CI = 0.88-0.91). In conclusion, we found that endoscopic diagnosis with NBI is an accurate test to diagnosis dysplasia of Barrett's esophagus.
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
J
J
Song
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
J
J
Zhang
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
J
J
Wang
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
X
X
Guo
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
S
S
Yu
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
J
J
Wang
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Y
Y
Liu
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
W
W
Dong
D000368:Aged; D001471:Barrett Esophagus / Q000150:complications / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal / Q000379:methods / Q000706:statistics & numerical data*; D004938:Esophageal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007422:Intestines / Q000473:pathology*; D008297:Male; D008679:Metaplasia / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D062048:Narrow Band Imaging / Q000379:methods / Q000706:statistics & numerical data*; D011230:Precancerous Conditions / Q000473:pathology; D012372:ROC Curve
Barrett's esophagus; diagnosis; meta-analysis; narrow band imaging