Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study.
OBJECTIVE
Circulating adiponectin levels have been shown to be associated with a risk of coronary heart disease (CHD). However, its primary role in protecting against the development of CHD remains controversial due to conflicting observations in prospective studies. To gain further insight into the primary role of adiponectin, our major objective was to investigate the relationship between single nucleotide polymorphisms (SNPs) of the adiponectin gene (ADIPOQ) and incident CHD in a population-based cohort with no CHD at baseline.


METHODS
We conducted a 16-year longitudinal study in 2196 subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). During 33 862 person-years of follow-up, 184 subjects developed CHD (cumulative incidence rate=5.4 per 1000 person-years). Nine ADIPOQ SNPs with potential functional relevance or shown to be associated with adiponectin levels and/or CHD were genotyped.


RESULTS
Among the nine ADIPOQ SNPs, +276G>T (rs1501299) was independently associated with incident CHD in men but not in women, even after adjustments for traditional cardiovascular risk factors (Padjusted=5.5×10(-3) to 0.023; hazard ratio=1.39-1.54). Furthermore, there was a significant association of the T allele of +276G>T with a lower adiponectin level (P=0.027; β (95% CI)=-0.05 (-0.10, -0.01).


CONCLUSIONS
This study demonstrated that +276G>T may be an independent predictor of CHD development. Our findings suggest that low adiponectin levels, as may be influenced by +276G>T, confer a higher risk of CHD, in keeping with a role of hypoadiponectinaemia in the development of CHD in the general population.
Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
Chloe Y Y
CY
Cheung
Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, AustraliaDepartment of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
Elaine Y L
EY
Hui
Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
Bernard M Y
BM
Cheung
Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
Y C
YC
Woo
Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, AustraliaDepartment of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
Aimin
A
Xu
Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
Carol H Y
CH
Fong
Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, AustraliaDepartment of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
K L
KL
Ong
Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
C Y
CY
Yeung
Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
Edward D
ED
Janus
Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, AustraliaDepartment of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
Hung-Fat
HF
Tse
Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, AustraliaDepartment of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia ksllam@hku.hk pcsham@hku.hk.
Pak C
PC
Sham
Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, AustraliaDepartment of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia ksllam@hku.hk pcsham@hku.hk.
Karen S L
KS
Lam
D052242:Adiponectin / Q000097:blood* / Q000235:genetics; D000328:Adult; D003324:Coronary Artery Disease / Q000097:blood* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
D052242:Adiponectin