Graphene oxide-DNA based sensors.
Since graphene oxide (GO) is readily available and exhibits exceptional optical, electrical, mechanical and chemical properties, it has attracted increasing interests for use in GO-DNA based sensors. This paper reviews the advances in GO-DNA based sensors using DNA as recognition elements. In solution, GO is as an excellent acceptor of fluorescence resonance energy transfer (FRET) to quench the fluorescence in dye labeled DNA sequences. This review discusses the emerging GO-DNA based sensors related to FRET for use in the detection of DNA, proteins, metal ions, cysteine (Cys), and others. The application of the electrochemical GO-DNA based sensors is also summarized because GO possesses exceptional electrochemical properties. The detection mechanisms and the advantages of GO are also revealed and discussed. GO-DNA based sensors perform well at low cost, and high sensitivity, and provide low detection limits. Additionally, GO-DNA based sensors should appear in the near future as scientists explore their usefulness and properties. Finally, future perspectives and possible challenges in this area are outlined.
Institute of Life Sciences, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, PR China. Electronic address: gaoli@ujs.edu.cn.
Li
L
Gao
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, PR China.
Chaoqun
C
Lian
Institute of Life Sciences, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, PR China.
Yang
Y
Zhou
Department of Gerontology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, PR China.
Lirong
L
Yan
Institute of Life Sciences, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, PR China.
Qin
Q
Li
Institute of Life Sciences, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, PR China.
Chunxia
C
Zhang
Institute of Life Sciences, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, PR China.
Liang
L
Chen
Institute of Life Sciences, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, PR China.
Keping
K
Chen
D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D004247:DNA / Q000032:analysis / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000295:instrumentation; D004867:Equipment Design; D019544:Equipment Failure Analysis; D031541:Fluorescence Resonance Energy Transfer / Q000295:instrumentation*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000295:instrumentation*; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation*; D017422:Sequence Analysis, DNA / Q000295:instrumentation*
D004247:DNA
DNA-based sensors; Electrochemical sensors; FRET; Graphene oxide