Low-grade B-cell lymphoma presenting primarily in the bone marrow.
Cases of low-grade B-cell lymphoma presenting primarily in the bone marrow are rare, and its clinicopathology remains unclear. We retrospectively examined patients with low-grade B-cell lymphoma presenting primarily in the bone marrow. Fourteen patients met the inclusion criteria, including 5 with lymphoplasmacytic lymphoma (LPL), 3 with chronic lymphocytic leukemia/small lymphocytic lymphoma, 2 with follicular lymphoma (FL), and 4 with low-grade B-cell lymphoma not otherwise specified (LGBCL-NOS). The median age was 69.5 years (range, 42-89 years), and a slight male predominance was noted (9 men and 5 women, 1.8: 1). Immunohistochemically, all cases were positive for CD20. One case was positive for CD138. Both cases of FL were positive for CD10 and B-cell lymphoma 2 (BCL-2), and immunoglobulin heavy locus (IgH)/B-cell lymphoma 2 rearrangement was observed by fluorescence in situ hybridization. The myeloid differentiation primary response gene (88) leucine to proline mutation was observed in 3 of 5 LPL, 1 of 2 FL, and 2 of 4 LGBCL-NOS patients. Paraproteinemia was observed in 10 patients; IgM and IgG paraproteinemia were observed in 6 and 3 patients, respectively. In this patient series, 3 patients had died at a median follow-up of 36.5 months; the cause of death of 1 LPL patient was malignant lymphoma itself. Thus, low-grade B-cell lymphoma presenting primarily in the bone marrow has various subtypes, and approximately one-third of the patients had LGBCL-NOS. The immunophenotypic features and myeloid differentiation primary response gene (88) leucine to proline mutation data of LGBCL-NOS suggested that some cases present with characteristics similar to those of LPL or marginal zone lymphoma.
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Kayoko
K
Iwatani
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan. Electronic address: katsuyoshi.t@h5.dion.ne.jp.
Katsuyoshi
K
Takata
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Yasuharu
Y
Sato
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Tomoko
T
Miyata-Takata
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Noriko
N
Iwaki
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Wei
W
Cui
Division of Pathology, Kanazawa University Hospital, Kanazawa 920-8641, Japan.
Seiko
S
Sawada-Kitamura
Division of Pathology, Chugoku Central Hospital, Fukuyama 720-0001, Japan.
Hiroshi
H
Sonobe
Division of Pathology, Hiroshima City Hospital, Hiroshima, 730-8518, Japan.
Maiko
M
Tamura
Department of Pathology, Toyama City Hospital, Toyama, 939-8511, Japan.
Katsuhiko
K
Saito
Division of Pathology, Mitoyo General Hospital, Kanonji 769-1695, Japan.
Katsuya
K
Miyatani
Division of Pathology, National Hospital Organization Iwakuni Clinical Center, Iwakuni 740-8510, Japan.
Rie
R
Yamasaki
Division of Pathology, National Hospital Organization Okayama Medical Center, Okayama 701-1192, Japan.
Ichiro
I
Yamadori
Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Nobuharu
N
Fujii
Division of Hematology, Toyama City Hospital, Toyama 939-8511, Japan.
Yasushi
Y
Terasaki
Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Yoshinobu
Y
Maeda
Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Mitsune
M
Tanimoto
Department of Pathology, Tokai University Institute of Medical Sciences, Isehara 259-1193, Japan.
Naoya
N
Nakamura
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Tadashi
T
Yoshino
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D060787:Neoplasm Grading; D010265:Paraproteinemias / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D012189:Retrospective Studies
Bone marrow; LGBCL-NOS; Low-grade B cell lymphoma; MYD88