Risk factors for appendiceal metastasis with epithelial ovarian cancer.
OBJECTIVE
To investigate the risk factors for appendiceal metastasis of epithelial ovarian cancer and compare findings with the previous studies.


METHODS
One hundred and thirty-four patients with epithelial ovarian cancer were assessed in this study. All of them had undergone a surgical procedure including appendectomy. Of these, 21 (15.7%) patients who had appendiceal metastasis were analyzed as the case group and the patients with no metastasis were the controls, compared according to stage, grade, histology of tumor, preoperative Ca125 levels, presence of ascites, peritoneal cytology, diameter and site of tumor considered as risk factors.


RESULTS
We found statistically significant differences between the groups in terms of stage, grade, right-sided tumor location, presence of ascites, diameter of tumor ≥ 10 cm and positive peritoneal cytology (p<0.05). In the logistic regression model, stage, grade, presence of ascites, right-sided location and diameter of tumor were independent risk factors. ROC curve analysis showed that stage, grade and diameter of the tumor were discriminative factors for appendiceal metastasis.


CONCLUSIONS
In epithelial ovarian cancer, stage, grade, presence of ascites, right-sided location and large tumor size have importance for estimation of risk of appendiceal metastasis. As we compare our findings with previous studies, there is no definite recommendation for the risk factors of appendiceal metastasis in epithelial ovarian cancer and more studies are needed.
Women's Health Education and Research Hospital, Ankara, Turkey E-mail : k.kokanal@yahoo.com.tr.
Mahmut Kuntay
MK
Kokanali
Ali Irfan
AI
Guzel
Selcuk
S
Erkilinc
Aytekin
A
Tokmak
Hasan Onur
HO
Topcu
Tayfun
T
Gungor
D002288:Adenocarcinoma, Mucinous / Q000209:etiology* / Q000473:pathology; D001063:Appendiceal Neoplasms / Q000209:etiology* / Q000556:secondary; D018284:Cystadenocarcinoma, Serous / Q000209:etiology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000473:pathology; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors