Cystoid macular edema: a correlation between macular volumetric parameters and visual acuity.
OBJECTIVE
To study in patients with cystoid macular edema (CME) the correlation between macular volumetric parameters on ocular coherence tomography (OCT) and visual acuity (VA).


METHODS
A retrospective consecutive cohort design was used.


METHODS
The sample included 167 examinations of 92 consecutive patients (130 eyes).


METHODS
Patients underwent spectral-domain OCT for CME from the years 2008 to 2010 at a tertiary medical centre. Background and VA data were recorded from the files. The custom-developed Cystometer software was used to calculate volumetric parameters from the OCT videos.


RESULTS
In univariate analyses, VA correlated best with cystoid macular volume (CMVol; R(2) = 8.57) and total macular volume (TMV; R(2) = 7.46). By underlying disease, the strongest correlation was found with CMVol (R(2) = 8.47) in patients with diabetic CME (n = 91) and with TMV (R(2) = 22.18) in patients with branch retinal vein occlusion (n = 46). In multiple regression analyses, TMV, age, and CMVol/TMV accounted for 17.57% of the variation in VA. In the diabetic CME group, CMVol/TMV and age accounted for 15.34% of the variation; in the branch retinal vein occlusion group, TMV accounted for 22.18% of the variation.


CONCLUSIONS
Macular volumetric parameters measured by OCT and Cystometer software significantly correlate with VA in patients with CME, with variations by underlying CME causative factor.
Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petach Tikva; Sackler School of Medicine, Tel Aviv University, Tel Aviv; Israel. Electronic address: mjmimmm@hotmail.com.
Michael
M
Mimouni
Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petach Tikva; Sackler School of Medicine, Tel Aviv University, Tel Aviv; Israel.
Yoav
Y
Nahum
Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petach Tikva.
Anna
A
Levant
Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petach Tikva.
Boris
B
Levant
Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petach Tikva; Sackler School of Medicine, Tel Aviv University, Tel Aviv; Israel.
Dov
D
Weinberger
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008269:Macular Edema / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*; D055815:Young Adult