Diagnostic value of screening tests in subgroups of women with recurrent pregnancy loss.
OBJECTIVE
To evaluate the diagnostic value of screening laboratory tests in women who had recurrent pregnancy loss (RPL).


METHODS
A total of 252 women with RPL managed in our tertiary referral research and education hospital were included in the study. Risk factors recorded involved age, gravidity, parity, number of prior live births, number of pregnancy losses, and thrombophlia tests. The cases were divided into three different groups and each group was analyzed separately.


RESULTS
There was no statistically significant difference between the first and second groups in terms of clinical and laboratory parameters (p > 0.05). In the third group, there was a statistically significant difference among cases in terms of parity, gravidity, number of pregnancy losses, serum AT III levels, APCR, and age of the women. According to the logistic regression model, odds ratios (95% CI) were 6.116 (3.797-9.852), 5.665 (2.657-12.079), 4.763 (3.099-7.321), 4.729 (3.080-7.260), 2.820 (1.836-4.333), and 1.911 (1.232-2.965), respectively.


CONCLUSIONS
We do not recommend the screening of all women with RPL, but in women with high parity and those who had prior live birth pregnancies, increased AT III, and APCR may be diagnostic markers for subsequent pregnancy loss.
Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey and.
Ali Irfan
AI
Guzel
Selçuk
S
Erkılınç
Irfan
I
Özer
Yusuf
Y
Celik
Nafiye
N
Yılmaz
Melike
M
Doğanay
D000026:Abortion, Habitual / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology; D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth / Q000453:epidemiology; D008423:Maternal Age; D010298:Parity; D011237:Predictive Value of Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D055815:Young Adult
Diagnostic value; recurrent pregnancy loss; screening tests; subgroup