Synthesis and isomerization of some novel pyrazolopyrimidine and pyrazolotriazolopyrimidine derivatives.
4-Imino-1-p-tolyl-1,4-dihydropyrazolo[3,4-d]pyrimidin-5-ylamine (2) and (1-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine (3) were prepared starting from ethyl 4-cyano-1-p-tolyl-1H-pyrazol-5-ylimidoformate (1). The structure of compound 3 was confirmed through preparation of the pyrazole derivatives 4 and 5. Also, the synthesis and structural characterization of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 7 and 9 and their isomerization to pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 6 and 8, respectively, under different suitable reaction conditions were reported. Moreover, the syntheses of 2-substituted-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 10 and 11 was described.
Photochemistry Department, National Research Center, Dokki, Cairo 1258943, Egypt. aymnelzeny@yahoo.com.
Aymn E
AE
Rashad
Photochemistry Department, National Research Center, Dokki, Cairo 1258943, Egypt. ahshamroukh@yahoo.com.
Ahmed H
AH
Shamroukh
Photochemistry Department, National Research Center, Dokki, Cairo 1258943, Egypt. randaabdelmegeid@yahoo.com.
Randa E
RE
Abdel-Megeid
Food Science and Nutrition Department, College of Food Science and Agriculture, King Saud University, Riyadh 11564, Kingdom of Saudi Arabia. hali@ksu.edu.com.
Hatem S
HS
Ali
D007536:Isomerism; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D011720:Pyrazoles; C477655:Pyrazolotriazolopyrimidine; D011743:Pyrimidines; D014230:Triazoles; C031280:pyrazole