Gene polymorphisms in female reproduction.
This chapter presents an overview of the gene polymorphisms underlying the functions of ovarian receptors and their clinical implications in the female fecundity. A selection of genetic studies revealing significant associations between receptor polymorphisms, gene mutations, and some pathological conditions (i.e., female infertility, premature ovarian failure, polycystic ovary syndrome, endometriosis) are reviewed.
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Universtita 4, Modena, 41121, Italy.
Livio
L
Casarini
Manuela
M
Simoni
D004715:Endometriosis; D005260:Female; D005298:Fertility / Q000235:genetics*; D005640:Follicle Stimulating Hormone / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007986:Luteinizing Hormone / Q000235:genetics*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008967:Molecular Biology / Q000379:methods; D009154:Mutation; D011085:Polycystic Ovary Syndrome / Q000235:genetics / Q000473:pathology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D016649:Primary Ovarian Insufficiency / Q000235:genetics / Q000473:pathology; D011980:Receptors, Progesterone / Q000235:genetics*
D011980:Receptors, Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)