Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder.
Bipolar disorder is characterized by internally affective fluctuations. The abnormality of inherently mental state can be assessed using resting-state fMRI data without producing task-induced biases. In this study, we hypothesized that the resting-state connectivity related to the frontal, striatal, and thalamic regions, which were associated with mood regulations and cognitive functions, can be altered for bipolar disorder. We used the Pearson's correlation coefficients to estimate functional connectivity followed by the hierarchical modular analysis to categorize the resting-state functional regions of interest (ROIs). The selected functional connectivities associated with the striatal-thalamic circuit and default mode network (DMN) were compared between bipolar patients and healthy controls. Significantly decreased connectivity in the striatal-thalamic circuit and between the striatal regions and the middle and posterior cingulate cortex was observed in the bipolar patients. We also observed that the bipolar patients exhibited significantly increased connectivity between the thalamic regions and the parahippocampus. No significant changes of connectivity related to the frontal regions in the DMN were observed. The changed resting-state connectivity related to the striatal-thalamic circuit might be an inherent basis for the altered emotional and cognitive processing in the bipolar patients.
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC; Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC.
Shin
S
Teng
Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan, ROC; Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC.
Chia-Feng
CF
Lu
Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC; The Neurological Institute, Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan, ROC; School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
Po-Shan
PS
Wang
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Cheng-Ta
CT
Li
Department of Medical Education and Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Pei-Chi
PC
Tu
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC; Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC.
Chih-I
CI
Hung
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, ROC.
Tung-Ping
TP
Su
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC; Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC; Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan, ROC.
Yu-Te
YT
Wu
D000328:Adult; D000465:Algorithms; D001714:Bipolar Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D063132:Connectome / Q000379:methods; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology; D011859:Radiography; D012146:Rest; D013788:Thalamus / Q000000981:diagnostic imaging / Q000503:physiopathology*