Long-term follow-up in two cases of intracranial Rosai-Dorfman Disease complicated by incomplete resection and recurrence.
BACKGROUND
Although intracranial Rosai-Dorfman disease is a principally benign lymphohistiocytosis, some patients run a relapsing or progressive course. However, reports about long-term follow-up are extremely rare.


METHODS
In two patients, initial tumor resection was incomplete or followed by recurrences over 3 years, which finally subsided after application of chemotherapy, and patients remained tumor-free for more than 7 years thereafter.


CONCLUSIONS
Up to now there is no agreement on how to treat complicated cases of intracranial Rosai-Dorfman disease; our good experience with adjuvant chemotherapy and long-term follow-up will contribute to treatment planning in complicated cases.
Department of Neurosurgery, Hospital Dr. Luis E. Aybar, Calle 6, Santo Domingo, Republica Dominicana ; Department of Neurosurgery, CEDIMAT, Plaza de la Salud, Santo Domingo, Republica Dominicana.
Diones
D
Rivera
Section of Neuropathology, Hospital Dr. Luis E. Aybar, Calle 6, Santo Domingo, Republica Dominicana.
Miguelina
M
Pérez-Castillo
Department of Hematology, Hospital Dr. Luis E. Aybar, Calle 6, Santo Domingo, Republica Dominicana.
Belkis
B
Fernández
Department of Radiology, CEDIMAT, Plaza de la Salud, Santo Domingo, Republica Dominicana.
Peter
P
Stoeter
Intracranial Rosai–Dorfman disease; chemotherapy; incomplete resection; long-term follow-up; recurrence