Stent placement for complex middle cerebral artery aneurysms.
BACKGROUND
To evaluate the safety and effectiveness of stent placement for ruptured or unruptured middle cerebral artery (MCA) aneurysms in a larger number.


METHODS
Between October 2003 and December 2012, data for 70 patients with 72 complex MCA aneurysms treated with stents at our institution were retrospectively collected and analyzed.


RESULTS
Eighty-five stents were successfully deployed in this series. However, failure of followed coiling was encountered in 2 (2.8%) tiny aneurysms of them. Of the 63 aneurysms treated with stent-assisted coiling, complete occlusion was achieved in 22 (34.9%), neck remnant in 15 (23.8%), and residual sac in 26 (36.5%). Of the 9 aneurysms treated with stent alone, the results were contrast stasis in 3 aneurysms and no change in 6. Procedure-related complications occurred in 9 (12.5%) procedures, including 7 of 27 (25.9%) with ruptured aneurysms and 2 of 45 (4.4%) with unruptured aneurysms, which resulted in 1 death and 5 disabilities. Univariate and multivariate analyses show that ruptured aneurysm is an independent factor for the outcome of these patients (odds ratio, 7.35; 95% confidence interval, 1.35-40.0). Angiographic follow-up results (mean, 10.5±8.8 months) showed that 72.1% (44 of 61) were completely occluded, 4.9% (3 of 61) recurred, and others were stable or had improved. Intrastent stenosis was observed in 1 (1.6%) patient, which was managed conservatively. During a clinical follow-up period ranging from 7 to 113 months (mean, 33.0±22.4 months), 1 disabled patient died from severe pneumonia, whereas the clinical status of the others had improved or was stable. Procedure-related morbidity/mortality during the follow-up for the ruptured and unruptured groups were 3.7%/3.7% and 0/0, respectively.


CONCLUSIONS
Our study shows that stent placement for the treatment of certain wide-neck MCA aneurysms is feasible, safe, and effective. However, stent placement for acutely ruptured MCA aneurysms harbors a much higher complication rate.
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Yu
Y
Zhou
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Peng-Fei
PF
Yang
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Qiang
Q
Li
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Rui
R
Zhao
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Yi-Bin
YB
Fang
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Yi
Y
Xu
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Bo
B
Hong
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wen-Yuan
WY
Zhao
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Qing-Hai
QH
Huang
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: liu118@vip.163.com.
Jian-Min
JM
Liu
D000328:Adult; D000368:Aged; D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D000925:Anticoagulants / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D002533:Cerebral Angiography; D000077144:Clopidogrel; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012189:Retrospective Studies; D015607:Stents; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D017211:Treatment Failure; D016896:Treatment Outcome
D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin
Stent; aneurysms; middle cerebral artery; ruptured; unruptured