Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense.
We compared anti-inflammatory activity of individual diterpene alkaloids isolated from Aconitum baikalense (napelline, songorine, hypaconitine, mesaconitine, 12-epinapelline N-oxide) under conditions of acute inflammation of different genesis. The tested substances showed high antiexudative activity comparable with that of sodium diclofenac. Unlike nonsteroidal anti-inflammatory drugs, diterpene alkaloids exerted no ulcerogenic effect.
Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, nes-yuliya@yandex.ru.
Yu V
YV
Nesterova
T N
TN
Povetieva
N I
NI
Suslov
G N
GN
Zyuz'kov
S G
SG
Aksinenko
S V
SV
Pushkarskii
A V
AV
Krapivin
D031841:Aconitum / Q000737:chemistry*; D000818:Animals; D021461:Animals, Outbred Strains; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004224:Diterpenes / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006614:Hindlimb / Q000187:drug effects / Q000473:pathology; D008808:Mice, Inbred CBA; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D010936:Plant Extracts