Relationship between lysophosphatidic acid and matrix metalloproteinase-9 plasma concentrations and carotid atheromatous plaque stability in patients with cerebral infarction.
OBJECTIVE
To investigate the correlation between plasma lysophosphatidic acid (LPA), matrix metalloproteinase (MMP)-9 and carotid atheromatous plaque stability in patients with cerebral infarction.


METHODS
Patients with cerebral infarction underwent carotid artery duplex ultrasonography and transcranial Doppler monitoring for detection of microemboli. Patients were stratified by plaque type (no plaque, intima thickening, unstable plaque, stable plaque) and presence or absence of micoremboli. Plasma LPA and MMP-9 were quantified.


RESULTS
LPA and MMP-9 concentrations were significantly higher and microemboli positivity was significantly more common in patients with unstable plaque (n = 21) than the other three groups (intima thickening, n = 16; stable plaque n = 41; no plaque; n = 12). There was a significant positive correlation between LPA and MMP-9 concentrations.


CONCLUSIONS
Plasma LPA and MMP-9 concentrations may be useful biomarkers in the clinical identification and prediction of unstable plaque, and in guiding treatment.
Department of Neurology, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
Zhibin
Z
Zhou
Department of Emergency Medicine, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China Lixiaohao77@163.com.
Xiaohao
X
Li
Department of Cardiology, Zhongshan Hospital of Hubei, Wuhan, China.
Bo
B
Yang
Department of Neurology, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
Dan
D
Jiang
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D002544:Cerebral Infarction / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D020766:Intracranial Embolism / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D008246:Lysophospholipids / Q000097:blood*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D018616:Ultrasonography, Doppler, Duplex
D015415:Biomarkers; D008246:Lysophospholipids; D020780:Matrix Metalloproteinase 9; C032881:lysophosphatidic acid
Lysophosphatidic acid; carotid atheromatous plaque; cerebral infarction; matrix metalloproteinase-9