Specific effects of chondroitin sulfate-modified hyaluronidase on the function of progenitor cells.
We have demonstrated the possibility of stimulation of the function of various types of precursor cells with hyaluronidase modified with chondroitin sulfate. Parenteral administration of modified hyaluronidase increased the number of fibroblast, granulomonocyte, and erythroid CFU in the hemopoietic tissue. The changes in the pool of mesenchymal progenitor cells were more pronounced in comparison with those induced by native enzyme.
Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, zgn@pharm.tsu.ru.
G N
GN
Zyuz'kov
A V
AV
Maksimenko
V V
VV
Zhdanov
E V
EV
Udut
A D
AD
Turashev
L A
LA
Miroshnichenko
E V
EV
Simanina
A V
AV
Chaikovskii
M Yu
MY
Minakova
A V
AV
Artamonov
A A
AA
Bekarev
P G
PG
Madonov
V V
VV
Udut
A M
AM
Dygai
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000502:physiology*; D002448:Cell Adhesion; D002452:Cell Count; D002809:Chondroitin Sulfates / Q000737:chemistry*; D005260:Female; D006821:Hyaluronoglucosaminidase / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008808:Mice, Inbred CBA; D044968:Regenerative Medicine; D013234:Stem Cells / Q000187:drug effects / Q000502:physiology*
D002809:Chondroitin Sulfates; D006821:Hyaluronoglucosaminidase