[Advances in research and development of universal influenza vaccines].
Vaccination is the primary strategy for the prevention and control of pandemic influenza. Because influenza virus is highly variable across strains, universal influenza vaccines need to be developed to address this problem. This review describes the research progress in conserved epitopes of influenza virus, the advances in the research and development of universal influenza vaccines based on the relatively conserved sequences of NP, M2e, HA2, and headless HA, the mechanisms of cross-protection, and the methods to improve cross-protection.
Li-Xia
LX
Zhang
Jian-Fang
JF
Zhou
Yue-Long
YL
Shu
Bao-Shou
BS
Yang
Zhao-Qing
ZQ
He
D000818:Animals; D003429:Cross Reactions; D006801:Humans; D009975:Orthomyxoviridae / Q000276:immunology*; D013045:Species Specificity; D014764:Viral Proteins / Q000276:immunology; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology*
D014764:Viral Proteins; D014765:Viral Vaccines