Disentangling the molecular genetic basis of personality: from monoamines to neuropeptides.
The present review/perspectives article provides a short overview of our current understanding of the molecular genetics of personality. In the first part, the most important gene candidates such as COMT or SLC6A4 gene are presented. Since several seminal review studies have recently been published on different facets of molecular genetics and personality/emotionality, we focus the second half of the present article on new relevant research directions. This includes a stronger focus on animal research based testing of candidate genes (e.g. neuropeptides such as oxytocin and vasopressin) and the use of á priori genotyping to increase statistical power. Moreover, we stress the importance of integrating cross-cultural data in future research designs and of inclusion of epigenetic measures in neuroscientifically oriented personality research. Finally, the Affective Neuroscience Personality Scales are introduced as a new promising tool for biologically oriented psychology/psychiatry research.
Department of Psychology, University of Bonn, Germany; Laboratory of Neurogenetics, University of Bonn, Germany; Center for Economics & Neuroscience, University of Bonn, Germany. Electronic address: christian.montag@uni-bonn-diff.de.
Christian
C
Montag
Department of Psychology, University of Bonn, Germany; Laboratory of Neurogenetics, University of Bonn, Germany; Center for Economics & Neuroscience, University of Bonn, Germany.
Martin
M
Reuter
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D009479:Neuropeptides / Q000378:metabolism*; D010551:Personality / Q000235:genetics*; D010554:Personality Disorders / Q000235:genetics* / Q000523:psychology
D015306:Biogenic Monoamines; D009479:Neuropeptides
ANPS; Candidate gene approach; GWAS; Molecular genetics; Personality; Perspectives; Review