Human intestinal spirochetosis is significantly associated with sessile serrated adenomas/polyps.
It remains unclear whether or not human intestinal spirochetosis (HIS) has any associated symptoms or lesions. In this study, we assessed the prevalence of HIS in sessile serrated adenomas/polyps (SSA/Ps) and their possible association. Following identification of early cecal cancer with SSA/P accompanied by a colonization of HIS, we went on to conduct a retrospective case-control study using endoscopically resected SSA/P specimens to examine the frequency of HIS infection in SSA/Ps. Nineteen SSA/P cases and 172 controls were obtained. The rate of HIS infection was significantly higher at 52.6% (10/19) in the SSA/P cases compared to the controls at 8.1% (14/172). Our SSA/P series were associated with a remarkably higher rate of HIS than controls or than previously reported. This is the first report to provide evidence for potential association between HIS and SSA/Ps.
Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan; Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Saori
S
Omori
Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan. Electronic address: kmabe@med.hokudai.ac.jp.
Katsuhiro
K
Mabe
Division of Pathology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Kanako
K
Hatanaka
Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan; Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Masayoshi
M
Ono
Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan; Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Mio
M
Matsumoto
Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan; Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Masakazu
M
Takahashi
Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Takeshi
T
Yoshida
Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Shoko
S
Ono
Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Yuichi
Y
Shimizu
Division of Gastroenterology, KKR Sapporo Medical Center, Sapporo, Hokkaido, Japan.
Nozomi
N
Sugai
Division of Pathology, KKR Sapporo Medical Center, Sapporo, Hokkaido, Japan.
Akira
A
Suzuki
Center of Gastroenterology, Otaru Ekisaikai Hospital, Otaru, Hokkaido, Japan.
Shinichi
S
Katsuki
Takahiro Fujii Clinic, Tokyo, Japan.
Takahiro
T
Fujii
Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Mototsugu
M
Kato
Department of Cancer Preventive Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Masahiro
M
Asaka
Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Naoya
N
Sakamoto
D000236:Adenoma / Q000382:microbiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000382:microbiology*; D007417:Intestinal Polyps / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D013145:Spirochaetales Infections / Q000150:complications* / Q000453:epidemiology*; D055815:Young Adult
Human intestinal spirochetosis; Serrated lesion; Sessile serrated adenoma/polyps