Synthesis of alkylidene pyrrolo[3,4-b]pyridin-7-one derivatives via Rh(III)-catalyzed cascade oxidative alkenylation/annulation of picolinamides.
A practical Rh(III)-catalyzed cascade olefination/annulation of picolinamides leading to pyrrolo[3,4-b]pyridines has been developed. The reaction shows wide scope, complete regiocontrol and excellent stereoselectivity.
Departamento de Química Orgánica, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. n.rodriguez@uam.es ramon.gomez@uam.es juancarlos.carretero@uam.es.
Ángel Manu
ÁM
Martínez
Nuria
N
Rodríguez
Ramón
R
Gómez Arrayás
Juan C
JC
Carretero
D000475:Alkenes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010848:Picolinic Acids / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*
D000475:Alkenes; D000577:Amides; D010848:Picolinic Acids; D011725:Pyridines; D011758:Pyrroles; D012238:Rhodium; C003142:picolinamide