Two cases of severe intoxication associated with analytically confirmed use of the novel psychoactive substances 25B-NBOMe and 25C-NBOMe.
BACKGROUND
A new group of novel psychoactive substance, the N-methoxybenzyl (NBOMe) derivatives of substituted phenethylamine, has recently emerged on the drug market, among which 25I-NBOMe and 25B-NBOMe have previously been implicated in clinical intoxications and fatalities. We report two cases of acute intoxication associated with these substances.


METHODS
Two male patients (17 and 31 years of age) had ingested drugs labelled as 'NBOMe' or 'Holland film' and developed confusion, agitation, hypertension, tachycardia, hyperthermia, sweating and dilated pupils. Other features included convulsion, rhabdomyolysis and deranged liver function. The patients required benzodiazepines and other drugs for the control of symptoms. Urine samples from both patients were analysed using liquid-chromatography tandem mass spectrometry (LC-MS/MS) following glucuronidase digestion and solid-phase extraction. Identification was based upon comparison of the retention time and enhanced product ion scan with reference standards. In both urine samples, 25B-NBOMe was detected. Additionally, 25C-NBOMe was identified in one of the urine samples.


CONCLUSIONS
The NBOMe compounds are highly potent 5HT2A receptor agonists and are also agonists at alpha-adrenergic receptors, which likely account for their serotonergic and sympathomimetic symptoms. The clinical testing of NBOMe drugs is not commonly available. Clinicians as well as laboratory staff play an important role in facilitating the detection of this group of potentially dangerous emerging drugs.
Hospital Authority Toxicology Reference Laboratory, Princess Margaret Hospital , Hong Kong , P. R. China.
M H Y
MH
Tang
C K
CK
Ching
M S H
MS
Tsui
F K C
FK
Chu
T W L
TW
Mak
D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000737:chemistry / Q000494:pharmacology / Q000506:poisoning; D000328:Adult; D002853:Chromatography, Liquid / Q000379:methods; D006213:Hallucinogens / Q000737:chemistry / Q000494:pharmacology / Q000506:poisoning*; D006801:Humans; D013287:Illicit Drugs / Q000737:chemistry / Q000494:pharmacology / Q000506:poisoning*; D008297:Male; D010627:Phenethylamines / Q000737:chemistry / Q000494:pharmacology / Q000506:poisoning*; D058826:Serotonin 5-HT2 Receptor Agonists / Q000737:chemistry / Q000494:pharmacology / Q000506:poisoning; D012720:Severity of Illness Index; D052616:Solid Phase Extraction / Q000379:methods; D015813:Substance Abuse Detection / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods
D000316:Adrenergic alpha-Agonists; D006213:Hallucinogens; D013287:Illicit Drugs; D010627:Phenethylamines; D058826:Serotonin 5-HT2 Receptor Agonists
Novel psychoactive substance; Phenethylamine; Serotonergic; Sympathomimetic; Toxicity