Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide.
Here we describe the use of a new open-source software package and a Raspberry Pi(®) computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater(®), used in the treatment of tuberculosis - and its reduced derivative piperazine-2-carboxamide.
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.
Richard J
RJ
Ingham
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.
Claudio
C
Battilocchio
Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA.
Joel M
JM
Hawkins
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.
Steven V
SV
Ley
automation; flow chemistry; hydration; hydrogenation; sustainable processing