Mixed antimony(V) complexes with different sugars to modulate the oral bioavailability of pentavalent antimonial drugs.
Previous studies have shown that the association of the drug meglumine antimoniate (MA) with β-cyclodextrin can improve its bioavailability by the oral route. In this work, ribose and maltose were investigated for their ability to form mixed or association complexes with MA, release MA and modulate the serum levels of Sb after oral administration in mice. Analysis of the MA/ribose composition by high performance liquid chromatography coupled to mass spectrometry (LCMS-IT-TOF) revealed the presence of mixed meglumine-Sb-ribose and Sb-ribose complexes. Analysis of the MA/maltose composition suggested the formation of MA-maltose association compounds. Circular dichroism characterization of these compositions following dilution in water at 37 °C suggested a partial and slow dissociation of the association compounds. When the MA/ribose composition was administered orally and compared to MA, the serum concentration of Sb was significantly lower after 1 h and greater after 3 h. On the other hand, the MA/maltose composition showed similar serum Sb concentration after 1 h and higher level of Sb after 3 h, when compared to MA. In conclusion, the present study has demonstrated the formation of mixed or association complexes of MA with sugars, such as maltose and ribose, which promoted sustained serum level of Sb after oral administration.
Department of Chemistry, Institute of Exact Sciences - Federal University of Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, MG, Brazil.
Weverson A
WA
Ferreira
Department of Chemistry, Institute of Exact Sciences - Federal University of Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, MG, Brazil.
Arshad
A
Islam
Department of Chemistry, Institute of Exact Sciences - Federal University of Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, MG, Brazil.
Aretha Priscilla S
AP
Andrade
Department of Physiology and Biophysics, Institute of Biological Sciences - Federal University of Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, MG, Brazil.
Flaviana R
FR
Fernandes
Department of Physiology and Biophysics, Institute of Biological Sciences - Federal University of Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, MG, Brazil.
Frédéric
F
Frézard
Department of Chemistry, Institute of Exact Sciences - Federal University of Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, MG, Brazil. demichel@netuno.lcc.ufmg.br.
Cynthia
C
Demicheli
D000284:Administration, Oral; D000818:Animals; D000965:Antimony / Q000008:administration & dosage* / Q000737:chemistry; D001682:Biological Availability; D002241:Carbohydrates / Q000008:administration & dosage* / Q000737:chemistry; D002942:Circular Dichroism; D003505:Cyclodextrins; D006801:Humans; D008536:Meglumine / Q000008:administration & dosage / Q000737:chemistry; D000077485:Meglumine Antimoniate; D051379:Mice; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry
D002241:Carbohydrates; D003505:Cyclodextrins; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate; D000965:Antimony