Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates.
IGFBP-2 (1) has been described as a brain tumor oncogene (2) and is widely expressed in cancers from different origins (3-8). IGFBP-2 alone cannot cause malignant transformation, yet progression of brain tumors to higher grade (9) and also has been provided as a protective element in earlier stages of multistage colon carcinogenesis (10). Therefore, it is crucial to understand the factors that determine expression patterns of IGFBP-2 under normal and malignant conditions. The present review provides a comprehensive update of known factors that have an impact on expression of IGFBP-2.
Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN) , Dummerstorf , Germany.
Andreas
A
Hoeflich
Ligandis GbR , Gülzow , Germany.
Elisa
E
Wirthgen
Reference and Translation Center for Cardiac Stem Cell Therapy , Rostock , Germany.
Robert
R
David
Pediatric Oncology, University Children's Hospital , Rostock , Germany.
Carl Friedrich
CF
Classen
Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN) , Dummerstorf , Germany.
Marion
M
Spitschak
Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN) , Dummerstorf , Germany.
Julia
J
Brenmoehl
IGFBP-2; estradiol; peptide hormones; steroids; vertebrates