Rh(III)-catalyzed synthesis of 1-aminoindole derivatives from 2-acetyl-1-arylhydrazines and diazo compounds in water.
A novel and direct approach to synthesize 1-aminoindole derivatives by Rh(iii)-catalyzed cyclization of 2-acetyl-1-arylhydrazines with diazo compounds via aryl C-H activation has been developed. This intermolecular annulation involving tandem C-H activation, cyclization and condensation steps proceeds efficiently in water, obviates the need of external oxidants, and displays a broad substituent scope.
State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), College of Chemistry, Nankai University, Tianjin 300071, China. bqwang@nankai.edu.cn.
Yujie
Y
Liang
Ke
K
Yu
Bin
B
Li
Shansheng
S
Xu
Haibin
H
Song
Baiquan
B
Wang
D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D006834:Hydrazines / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D001391:Azo Compounds; D006834:Hydrazines; D007211:Indoles; D009942:Organometallic Compounds; D014867:Water; D012238:Rhodium