Expression of the HPV18E2 gene in cervical cancer and premalignant lesions and its clinical significance.
This study aims to observe the expression of the HPV18E2 gene in cervical cancer and premalignant lesions and to investigate its clinical significance. The expression of the HPV18E2 gene in the cervical tissues obtained from 38 women with cervical lesions was detected using the RT-PCR method. The pathological changes were graded based on cervical intraepithelial neoplasia (CIN) criteria. The HPV18E2 gene was expressed mainly in cervical premalignant lesions, 60 % in Grade I CIN, 33.3 % in Grade II CIN, and 28.6 % in Grade III CIN. No expression was detected in cervical cancer and chronic cervical inflammation. This study suggests that peptides vaccine targeting the HPV18E2 protein may disrupt and prohibit the progress of diseases induced by HPV 18 infection (i.e., CIN and cervical cancer).
Department of Gynecology and Obstetrics, 324th Hospital of PLA, Chongqing, 400020, People's Republic of China.
Ling
L
Mou
Bin
B
Wu
Ya
Y
Hu
Ying
Y
Lan
Feng-Lin
FL
Lv
D000328:Adult; D000368:Aged; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D052161:Human papillomavirus 18 / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*; D055815:Young Adult
D009856:Oncogene Proteins, Viral; C069102:oncogene protein E2, Human papillomavirus type 18