Whole genome analysis of sierra nevada virus, a novel mononegavirus in the family nyamiviridae.
A novel mononegavirus was isolated in 1975 from ticks (Ornithodoros coriaceus) collected during investigation of an outbreak of epizootic bovine abortion (EBA) in northern California. It was originally designated "bovine abortion-tick virus" (BA-T virus). The EBA is now known to be associated with a deltaproteobacterium infection, and not a virus. The BA-T virus had remained uncharacterized until now. We have determined by electron microscopy, serology, and genome sequencing that the BA-T virus is a fourth member of the newly proposed family Nyamiviridae, and we have renamed it Sierra Nevada virus (SNVV). Although antigenically distinct, phylogenetically SNVV is basal to Nyamanini virus (NYMV) and Midway virus (MIDWV), two other tick-borne agents. Although NYMV was found to infect land birds, and MIDWV seabirds, it is presently unknown whether SNVV naturally infects birds or mammals.
Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Tsinghua University School of Medicine, Beijing, China; Center for Biodefense and Emerging Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.
Matthew B
MB
Rogers
Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Tsinghua University School of Medicine, Beijing, China; Center for Biodefense and Emerging Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.
Lijia
L
Cui
Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Tsinghua University School of Medicine, Beijing, China; Center for Biodefense and Emerging Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.
Adam
A
Fitch
Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Tsinghua University School of Medicine, Beijing, China; Center for Biodefense and Emerging Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.
Vsevolod
V
Popov
Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Tsinghua University School of Medicine, Beijing, China; Center for Biodefense and Emerging Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.
Amelia P A
AP
Travassos da Rosa
Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Tsinghua University School of Medicine, Beijing, China; Center for Biodefense and Emerging Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.
Nikos
N
Vasilakis
Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Tsinghua University School of Medicine, Beijing, China; Center for Biodefense and Emerging Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.
Robert B
RB
Tesh
Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Tsinghua University School of Medicine, Beijing, China; Center for Biodefense and Emerging Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas elodie.ghedin@nyu.edu.
Elodie
E
Ghedin
D000034:Abortion, Veterinary / Q000821:virology; D000595:Amino Acid Sequence; D000818:Animals; D001096:Arachnid Vectors / Q000821:virology; D001483:Base Sequence; D002417:Cattle; D002418:Cattle Diseases / Q000821:virology*; D002522:Chlorocebus aethiops; D002874:Chromosome Mapping; D005260:Female; D016679:Genome, Viral; D051379:Mice; D046529:Microscopy, Electron, Transmission; D058977:Molecular Sequence Annotation; D018096:Mononegavirales / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D018701:Mononegavirales Infections / Q000662:veterinary* / Q000821:virology; D026861:Ornithodoros / Q000821:virology; D010802:Phylogeny; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014709:Vero Cells