Discrimination of adenine nucleotides and pyrophosphate in water by a zinc complex of an anthracene-based cyclophane.
Combining metal-anion coordination and π-π stacking interactions, a zinc complex of a novel anthracene-based cyclophane was designed to recognise adenine nucleoside polyphosphates. This complex was found to show selective fluorescence enhancement for ATP, ADP, AMP and PPi in neutral aqueous solution. Among them, ADP induced the largest fluorescence change to the complex, while ATP showed the strongest binding affinity to the complex. This property was used to sense ATP in the presence of excess amounts of other phosphates such as ADP, AMP, PPi and Pi.
Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, P. R. China. gf256@mail.ccnu.edu.cn.
Ping
P
Hu
Shengjun
S
Yang
Guoqiang
G
Feng
D000227:Adenine Nucleotides / Q000737:chemistry*; D000873:Anthracenes / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D011756:Diphosphates / Q000737:chemistry*; D004988:Ethers, Cyclic / Q000737:chemistry*; D007477:Ions; D007700:Kinetics; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D000227:Adenine Nucleotides; D000873:Anthracenes; D056831:Coordination Complexes; D011756:Diphosphates; D004988:Ethers, Cyclic; D007477:Ions; D014867:Water; C107241:diphosphoric acid; C034020:anthracene; D015032:Zinc