Nitrogen-containing dimeric nor-multiflorane triterpene from a Turraea sp.
The new triterpene turranoic acid (1) and the new N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the nonsmall lung cancer cell line H522-T1 with an IC50 value of 16.4 μM.
Centre National d'Application des Recherches Pharmaceutiques B.P , 702, Antananarivo 101, Madagascar.
Vincent E
VE
Rasamison
L Harinantenaina
LH
Rakotondraibe
Carla
C
Slebodnick
Peggy J
PJ
Brodie
Michel
M
Ratsimbason
Karen
K
TenDyke
Yongchun
Y
Shen
Lucien M
LM
Randrianjanaka
David G I
DG
Kingston
D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C000589441:esculentoic acid; C000589440:triptocallic acid B; C000589439:turraenine; C000589438:turranoic acid; D002738:Chloroquine; D009584:Nitrogen