Lipid metabolites and their differential pro-arrhythmic profiles: of importance in the development of a new anti-arrhythmic pharmacology.
Arrhythmias have been treated for a long time with drugs that mainly target the ionic pumps and channels. These anti-arrhythmic regimens per se introduce new arrhythmias, which can be detrimental to patients. Advances in development of novel pharmacology without introduction of iatrogenic arrhythmias are thus favorable for an effective treatment of arrhythmias. Electrophysiological stability of the heart has been shown to be closely associated with cardiac metabolism. The present effective anti-arrhythmic drugs such as beta-blockers and amiodarone have profound beneficial effects in regulating myocardial metabolism. Aiming at decreasing production of toxic metabolites or preventing accumulation of arrhythmogenic lipids perhaps is a good strategy to effectively control arrhythmias. Therefore, a better understanding of the pro-arrhythmic profiles of cardiac metabolites helps to explore a new generation of metabolically oriented anti-arrhythmic medications. In this review, we present several lipid metabolites and summarize their arrhythmogenic characteristics.
Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, Bruna stråket 16, 413 45, Gothenburg, Sweden, shao.yangzhen@wlab.gu.se.
Yangzhen
Y
Shao
Bjorn
B
Redfors
David
D
Benoist
Sigfus
S
Gizurarson
Elmir
E
Omerovic
D000319:Adrenergic beta-Antagonists / Q000378:metabolism / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000378:metabolism / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D002518:Ceramides / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008244:Lysophosphatidylcholines / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D010172:Palmitoylcarnitine / Q000378:metabolism*
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D002518:Ceramides; D005230:Fatty Acids, Nonesterified; D008244:Lysophosphatidylcholines; D010172:Palmitoylcarnitine