[The effect of magnesium nitrate on the outcome of experimental acute ischemic stroke].
Objectives. To explore the effect of inorganic forms of magnesium (magnesium nitrate, magnesium sulfate, magnesium chloride) on the course of experimental ischemic stroke (II). Material and methods. The experimental ischemic stroke caused by the occlusion of two carotid arteries in Wistar rats was studied. Animals were divided into 6 case (n=168) and 2 control groups (n=56). In case groups, magnesium was injected 1h before the occlusion of both carotid arteries and 1-2h after the brain ischemia. Control groups received physiological solution in the same periods. Results. Magnesium nitrate, regardless of the period of injection, had the significant positive effect on the dynamics of neurological lesions and mortality of animals. Conclusions. Magnesium nitrate meets the majority of criteria required for ideal pharmacological drugs: it is inexpensive, easy available, easy injectable and does not cause any serious adverse effects.
Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova.
V S
VS
Kuzenkov
A L
AL
Krushinskiĭ