Effects of statins-use for patients with aneurysmal subarachnoid hemorrhage: a meta-analysis of randomized controlled trials.
Aneurysmal subarachnoid hemorrhage (aSAH)-induced cerebral vasospasm and delayed ischemic neurological deficit (DIND) are the major causes of morbidity and mortality in patients with aSAH. The effects of statins-use for patients with aSAH remain controversial. Here,a total of 249 patients from six randomized controlled trials(RCTs) were subjected to meta-analysis. No significant decrease was found in the incidence of vasospasm(RR, 0.80; 95% CI, 0.54-1.17), with substantial heterogeneity (I(2) = 49%, P = 0.08), which was verified by the further sensitivity analysis and subgroup meta-analysis. Furthermore, no significant difference was presented in the incidence of poor neurological outcome(RR, 0.94; 95% CI, 0.77-1.16), and potential side effects(RR, 2.49; 95% CI, 0.75-8.33). Nevertheless, significant difference was reported in the occurrence of DIND(RR, 0.58; 95% CI, 0.37-0.92) and mortality(RR, 0.30; 95% CI, 0.14-0.64). At present, although statins-use in the patients with aSAH should not be considered standard care at present, statins-use may have the potential effects in the prevention of mortality in patients with aSAH.
1] The Department of Neurosurgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China [2].
Shao-Hua
SH
Su
1] The Department of Trauma Center, Emergency, Shanghai Changning Central Hospital, Shanghai 200036, China [2].
Wei
W
Xu
The Department of Neurosurgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Jian
J
Hai
The Department of Neurosurgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Yi-Fang
YF
Wu
The Department of Neurosurgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Fei
F
Yu
D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D015994:Incidence; D016017:Odds Ratio; D011379:Prognosis; D017594:Publication Bias; D016032:Randomized Controlled Trials as Topic; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000453:epidemiology*; D016896:Treatment Outcome; D020301:Vasospasm, Intracranial / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors