[Preliminary study of contrast-enhanced ultrasound in correlation between muscle perfusion deficits in lower extremity arterial disease and its collateralization].
OBJECTIVE
To explore the value of contrast-enhanced ultrasound (CEUS) as a new method in evaluating the correlation between muscle perfusion deficits and collateralization in lower extremity arterial disease (LEAD).


METHODS
Ultrasound contrast agent was injected into peripheral vein of 80 control subjects and 80 LEAD patients. Its appearance in calf muscle was detected by contrast-enhanced ultrasound. Time intensity curves (TIC) and time to peak intensity (TTP) were analyzed. And collateral formation was evaluated by computed tomography angiography (CTA) .


RESULTS
TTP in LEAD group was statistically higher than that in control group (59.1 vs 38.6 s, P < 0.01) . The TTP difference between two investigators who evaluate the row data in a blinded way was 0.29 s and the area under receiver operating characteristic (ROC) curve 0.92. A TTP cutoff at 47.5 s was associated with 91% positive predictive value statistically. TTP in LEAD with bad collateralization was statistically higher than that in LEAD with good collateralization (67.9 vs 50.4 s, P < 0.01) .


CONCLUSIONS
As a consistent method of evaluating muscle perfusion deficits, CEUS shows a good correlation with the extent of collateral formation in LEAD.
Department of Ultrasound, Affiliated Tongji Hospital, Tongji University, Shanghai 200065, China.
Ye
Y
Song
Yuan
Y
Li
Wen
W
Lu
Email:gao_yuan68@hotmail.com.
Yuan
Y
Gao
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D016022:Case-Control Studies; D003097:Collateral Circulation; D003287:Contrast Media; D005260:Female; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply*; D014463:Ultrasonography
D003287:Contrast Media