Chemoenzymatic synthesis of polymeric materials using lipases as catalysts: a review.
In the past two decades, enzymatic polymerization has rapidly developed and become an important polymer synthesis technique. However, the range of polymers resulting from enzymatic polymerization could be further expanded through combination with chemical methods. This review systematically introduces recent developments in the combination of lipase-catalyzed polymerization with atom transfer radical polymerization (ATRP), kinetic resolution, reversible addition-fragmentation chain transfer (RAFT), click reaction and carbene chemistry to construct polymeric materials like block, brush, comb and graft copolymers, hyperbranched and chiral polymers. Moreover, it presents a thorough and descriptive evaluation of future trends and perspectives concerning chemoenzymatic polymerization. It is expected that combining enzymatic polymerization with multiple chemical methods will be an efficient tool for producing more highly advanced polymeric materials.
Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun 130012, China; National Engineering Laboratory for AIDS Vaccine, Jilin University, Changchun 130012, China; School of Life Sciences, Jilin University, Changchun 130012, China.
Yan
Y
Yang
Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun 130012, China; School of Life Sciences, Jilin University, Changchun 130012, China.
Jianxu
J
Zhang
Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun 130012, China; School of Life Sciences, Jilin University, Changchun 130012, China.
Di
D
Wu
Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun 130012, China; School of Life Sciences, Jilin University, Changchun 130012, China.
Zhen
Z
Xing
Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun 130012, China; National Engineering Laboratory for AIDS Vaccine, Jilin University, Changchun 130012, China; School of Life Sciences, Jilin University, Changchun 130012, China.
Yulin
Y
Zhou
Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun 130012, China; National Engineering Laboratory for AIDS Vaccine, Jilin University, Changchun 130012, China; School of Life Sciences, Jilin University, Changchun 130012, China. Electronic address: shiw@jlu.edu.cn.
Wei
W
Shi
Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun 130012, China; National Engineering Laboratory for AIDS Vaccine, Jilin University, Changchun 130012, China; School of Life Sciences, Jilin University, Changchun 130012, China. Electronic address: quanshun@jlu.edu.cn.
Quanshun
Q
Li
D001709:Biotechnology; D057930:Click Chemistry; D007700:Kinetics; D008049:Lipase / Q000737:chemistry / Q000378:metabolism; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry
D011108:Polymers; D008049:Lipase
ATRP; Carbene chemistry; Chemoenzymatic polymerization; Click reaction; Kinetic resolution; Lipase; RAFT