Individual telomere length decay in patients with spondyloarthritis.
Telomere length was sequentially determined in peripheral blood leukocytes (PBL) from patients with ankylosing spondylitis (AS; n = 44) and psoriatic arthritis (PsA; n = 42) followed through 2.93 ± 0.99 years, using a quantitative PCR (qPCR) assay. The initial telomere size from PsA patients was higher than those with cutaneous psoriasis only (n = 53), possibly due to the inflammatory condition. The qPCR assay was sensitive enough to evidence a significant telomere length shortening in PBL from practically all subjects and PsA patients showed a higher rate of loss of telomere sequence than patients with AS during the follow-up time.
Genetics Unit, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), As Xubias, 84, 15006 A Coruña, Spain; Laboratorio de Genética Molecular y Radiobiología, Centro Oncológico de Galicia, c/ Doctor Camilo Veiras n°1, 15009 A Coruña, Spain.
María
M
Tamayo
Clinical Epidemiology and Biostatistics Unit, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), As Xubias, 84, 15006 A Coruña, Spain.
Sonia
S
Pértega
Genetics Unit, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), As Xubias, 84, 15006 A Coruña, Spain.
Alejandro
A
Mosquera
Genetics Unit, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), As Xubias, 84, 15006 A Coruña, Spain.
Montserrat
M
Rodríguez
Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), As Xubias, 84, 15006 A Coruña, Spain.
Francisco J
FJ
Blanco
Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), As Xubias, 84, 15006 A Coruña, Spain.
José Luis
JL
Fernández-Sueiro
Unidad de Genética, Facultad de Biología, Universidad Autónoma de Madrid, Spain.
Jaime
J
Gosálvez
Genetics Unit, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), As Xubias, 84, 15006 A Coruña, Spain; Laboratorio de Genética Molecular y Radiobiología, Centro Oncológico de Galicia, c/ Doctor Camilo Veiras n°1, 15009 A Coruña, Spain. Electronic address: Jose.Luis.Fernandez.Garcia@sergas.es.
José Luis
JL
Fernández
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007962:Leukocytes / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011565:Psoriasis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016615:Telomere / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D059505:Telomere Homeostasis
Ankylosing spondylitis; Psoriasis; Psoriatic arthritis; Telomere length; qPCR