Spontaneous nonneoplastic lesions in control Syrian hamsters in three 24-month long-term carcinogenicity studies.
Information about the incidence of spontaneously occurring, nonneoplastic background findings in Syrian hamsters is essential if Syrian hamsters are to be used for toxicity studies. Male and female Syrian hamsters of the strain Han:AURA from the Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) breeding colony were maintained as control animals for carcinogenicity studies and were examined for the presence of nonneoplastic background findings either when they died or when the study was terminated. The nonneoplastic background lesions observed at an incidence of >50% (high), >25% (moderate), and >10% (low) in either male or female animals or in both sexes in one or more long-term studies are detailed. The results are compared to previous published reports of nonneoplastic, spontaneous background lesions in Syrian hamsters. Background information about the incidence of background lesions in Syrian hamsters on short- and long-term studies is useful to both toxicologists and toxicological pathologists.
Cerberus, Thebarton, South Australia, Australia efmcinnes@aol.com.
Elizabeth F
EF
McInnes
Fraunhofer Institute for Toxicology, and Experimental Medicine (ITEM), Hannover, Germany.
Heinrich
H
Ernst
Nycomed GmbH, Konstanz, Germany.
Paul-Georg
PG
Germann
D000820:Animal Diseases / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D000818:Animals; D015197:Carcinogenicity Tests; D006224:Cricetinae; D005260:Female; D015994:Incidence; D008297:Male; D008647:Mesocricetus / Q000502:physiology*; D009369:Neoplasms / Q000453:epidemiology / Q000473:pathology; D010336:Pathology / Q000592:standards*; D012015:Reference Standards; D014116:Toxicology / Q000592:standards*
animal models; background; hamster; histopathology; rodent pathology