Influence of anodal transcranial direct current stimulation (tDCS) over the right angular gyrus on brain activity during rest.
Although numerous studies examined resting-state networks (RSN) in the human brain, so far little is known about how activity within RSN might be modulated by non-invasive brain stimulation applied over parietal cortex. Investigating changes in RSN in response to parietal cortex stimulation might tell us more about how non-invasive techniques such as transcranial direct current stimulation (tDCS) modulate intrinsic brain activity, and further elaborate our understanding of how the resting brain responds to external stimulation. Here we examined how activity within the canonical RSN changed in response to anodal tDCS applied over the right angular gyrus (AG). We hypothesized that changes in resting-state activity can be induced by a single tDCS session and detected with functional magnetic resonance imaging (fMRI). Significant differences between two fMRI sessions (pre-tDCS and post-tDCS) were found in several RSN, including the cerebellar, medial visual, sensorimotor, right frontoparietal, and executive control RSN as well as the default mode and the task positive network. The present results revealed decreased and increased RSN activity following tDCS. Decreased RSN activity following tDCS was found in bilateral primary and secondary visual areas, and in the right putamen. Increased RSN activity following tDCS was widely distributed across the brain, covering thalamic, frontal, parietal and occipital regions. From these exploratory results we conclude that a single session of anodal tDCS over the right AG is sufficient to induce large-scale changes in resting-state activity. These changes were localized in sensory and cognitive areas, covering regions close to and distant from the stimulation site.
Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School, RWTH Aachen University, Aachen, Germany; Brain Imaging Facility, Interdisciplinary Center for Clinical Research, Medical School, RWTH Aachen University, Aachen, Germany; Neurological Clinic, Section Neuropsychology, Medical School, RWTH Aachen University, Aachen, Germany.
Benjamin
B
Clemens
Department of Psychology, Eberhard Karls University, Tübingen, Germany; Knowledge Media Research Center, IWM-KMRC, Tübingen, Germany.
Stefanie
S
Jung
Brain Imaging Facility, Interdisciplinary Center for Clinical Research, Medical School, RWTH Aachen University, Aachen, Germany.
Gianluca
G
Mingoia
Brain Imaging Facility, Interdisciplinary Center for Clinical Research, Medical School, RWTH Aachen University, Aachen, Germany.
David
D
Weyer
Department of Germanic Linguistics, Philipps-University Marburg, Marburg, Germany.
Frank
F
Domahs
Brain Imaging Facility, Interdisciplinary Center for Clinical Research, Medical School, RWTH Aachen University, Aachen, Germany; Neurological Clinic, Section Neuropsychology, Medical School, RWTH Aachen University, Aachen, Germany.
Klaus
K
Willmes
D000328:Adult; D004558:Electric Stimulation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000502:physiology*; D012146:Rest / Q000502:physiology*; D065908:Transcranial Direct Current Stimulation / Q000379:methods*