Computational studies of the first order kinetic reactions for mononuclear copper(II) complexes having a hard-soft NS donor ligand.
The chelation behaviour of 4-((E)-2-(1-(thiophen-2-yl)ethylidene)hydrazinyl)-1-(4-methoxyphenyl)-1H-pyrrole-3-carbonitrile (HL) towards Cu(II) ions has been investigated. These Cu(II) complexes are characterized by elemental analyses, molar-solid conductance, ESR, FTIR and electronic spectral studies. Also, the kinetic and thermodynamic parameters (Ea, A, ΔH, ΔS, ΔG) for all thermal decomposition steps have been evaluated using Coats-Redfern and Horowitz-Metzger methods. Furthermore, antimicrobial activity of the ligand and its complexes were studied against Gram-negative bacteria: Escherichia coli, Gram-positive Bacillus cereus, Bacillus subtilis and pathogenic fungi Pseudomonas aeruginosa by using minimum inhibitory concentrations (MICs) method.
Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt. Electronic address: rania.zaky@yahoo.com.
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Zaky
Department of Toxic and Narcotic Drug, Forensic Medicine, Mansoura Laboratory, Medicolegal Organization, Ministry of Justice, Egypt.
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Yousef
Spectroscopy Department, Physics Division, National Research Centre, Cairo, Egypt.
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Abdelghany
D000890:Anti-Infective Agents / Q000737:chemistry*; D001409:Bacillus cereus / Q000378:metabolism; D001412:Bacillus subtilis / Q000378:metabolism; D003201:Computers; D003300:Copper / Q000737:chemistry*; D004553:Electric Conductivity; D004578:Electron Spin Resonance Spectroscopy; D004926:Escherichia coli / Q000378:metabolism; D006835:Hydrazones / Q000737:chemistry; D007700:Kinetics; D008024:Ligands; D060526:Magnetic Fields; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000378:metabolism; D012984:Software; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013816:Thermodynamics
D000890:Anti-Infective Agents; D006835:Hydrazones; D008024:Ligands; D003300:Copper
Antimicrobial activity; Copper(II) complexes; ESR; FTIR; Thermal analysis