Recognizing and correcting failures in glioblastoma treatment.
While current treatment remains universal for glioblastoma, recent evidence has demonstrated marked heterogeneity in their molecular profiles. Due to the near universal rate of recurrence, attention has focused on individualized treatment and subgroup population differences that may influence the efficacy of adjuvant therapy. Recent studies have implicated chemo-radioresistant GBM stem cells (GSCs) in the propagation of heterogeneous tumor profiles. As a result, there has been a shift to classify and target GSCs in order to increase survival and delay relapse. The overall objective of our editorial is to highlight current failures in GBM treatment and to propose novel personalized methods to correct our shortcomings in GBM treatment.
Department of Neurological Surgery, University of Miami School of Medicine , Miami, Florida , USA.
Ashish H
AH
Shah
Regina
R
Graham
Amade
A
Bregy
Michael
M
Thambuswamy
Ricardo J
RJ
Komotar
D001932:Brain Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D019008:Drug Resistance, Neoplasm; D005909:Glioblastoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D014411:Neoplastic Stem Cells; D057285:Precision Medicine
Editorial; Glioblastoma; Treatment