Extracellular RNA mediates and marks cancer progression.
Different types of RNAs identified thus far represent a diverse group of macromolecules that are involved in the regulation of different biological processes. RNA is generally thought to be localized primarily in the nucleus and cytoplasm; however, some types of RNA have been detected in the extracellular milieu. These extracellular RNA (exRNA) molecules are protected from degradation and it is now widely accepted that extracellular vesicles and ribonucleoprotein particles serve as transport vehicles for exRNA among cells. The functional consequence of this transfer of genetic information probably encompasses a broad range of normal developmental and physiologic processes in many organisms. This review will focus on the role of exRNA communication in cancer. We will focus on different types of RNA species identified and characterized within tumor-derived extracellular vesicles. Further, we will describe the role of exRNAs in cancer progression, as well as their potential for use as diagnostic biomarkers and therapeutic tools for monitoring and treating cancer, respectively.
Department of Neurosurgery, University of Colorado Denver School of Medicine, Aurora, CO, USA. Electronic address: jasmina.redzic@ucdenver.edu.
Jasmina S
JS
Redzic
Departments of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, MA, USA. Electronic address: Balaj.Leonora@mgh.harvard.edu.
Leonora
L
Balaj
Departments of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, MA, USA. Electronic address: k.vd.vos@nki.nl.
Kristan E
KE
van der Vos
Departments of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, MA, USA. Electronic address: breakefield@hms.harvard.edu.
Xandra O
XO
Breakefield
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology; D018450:Disease Progression; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D012313:RNA / Q000378:metabolism*
D014408:Biomarkers, Tumor; D012313:RNA
Cancer; Extracellular vesicles; RNA