Mechanisms of epigenetic memory and addiction.
Epigenetic regulation of cellular identity and function is at least partly achieved through changes in covalent modifications on DNA and histones. Much progress has been made in recent years to understand how these covalent modifications affect cell identity and function. Despite the advances, whether and how epigenetic factors contribute to memory formation is still poorly understood. In this review, we discuss recent progress in elucidating epigenetic mechanisms of learning and memory, primarily at the DNA level, and look ahead to discuss their potential implications in reward memory and development of drug addiction.
Howard Hughes Medical Institute, Boston, MA, USA Program in Cellular and Molecular Medicine Boston Children's Hospital, Boston, MA, USA Department of Genetics, Harvard Medical School, Boston, MA, USA.
Luis M
LM
Tuesta
Howard Hughes Medical Institute, Boston, MA, USA Program in Cellular and Molecular Medicine Boston Children's Hospital, Boston, MA, USA Department of Genetics, Harvard Medical School, Boston, MA, USA Harvard Stem Cell Institute Harvard Medical School, Boston, MA, USA yzhang@genetics.med.harvard.edu.
Yi
Y
Zhang
D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D006657:Histones / Q000378:metabolism; D006801:Humans; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D019966:Substance-Related Disorders / Q000235:genetics*
D006657:Histones
DNA methylation; addiction; epigenetics; histone modifications; learning & memory