Analysis of HLA-G gene polymorphism and protein expression in invasive breast ductal carcinoma.
The human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule predominantly expressed in trophoblastic placental cells to protect the fetus during pregnancy. However, evidence has shown that this molecule may be implicated in the immune escape mechanism of tumor cells. Thus, the aim of this study was to evaluate the frequency of 14-bp insertion/deletion HLA-G polymorphism, as well as the expression of this molecule in patients with invasive breast ductal carcinoma (IDC). A significant association between the expression of HLA-G and the presence of metastasis in lymph nodes (p=0.01) was observed and the expression of HLA-G was significantly higher in patients with shorter survival time (p=0.03). The analysis suggests that the polymorphism observed in patients with IDC may be inducing a higher expression of the HLA-G molecule, which may possibly contribute to shorter survival time and a worse clinical prognosis for such patients.
Master's Program in Genetics, Pontifical Catholic University of Goiás, Goiânia, Goiás 74000, Brazil.
Caroline Steglich
CS
Ramos
Department of Stomatology [Oral Pathology], Dental School, Federal University of Goiás, Goiânia, Goiás 74000, Brazil.
Andréia Souza
AS
Gonçalves
Departament of Medicine, Pontifical Catholic University of Goiás, Goiânia, Goiás 74000, Brazil.
Larissa Cardoso
LC
Marinho
Departament of Medicine, Federal University of Goiás, Goiânia, Goiás 74000, Brazil.
Melissa Ameloti
MA
Gomes Avelino
Master's Program in Genetics, Pontifical Catholic University of Goiás, Goiânia, Goiás 74000, Brazil; Departament of Medicine, Pontifical Catholic University of Goiás, Goiânia, Goiás 74000, Brazil; Laboratory of Oncogenetics and Radiobiology, Association of Cancer Combat in Goiás, Brazil.
Vera Aparecida
VA
Saddi
Departament of Medicine, Pontifical Catholic University of Goiás, Goiânia, Goiás 74000, Brazil.
Aryanne Cristina
AC
Lopes
Institute of Education and Research, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais 31000, Brazil.
Renata Toscano
RT
Simões
Department of Biology, State University of Goiás, Morrinhos, Goiás 75000, Brazil. Electronic address: wastowski@gmail.com.
Isabela Jubé
IJ
Wastowski
D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000276:immunology / Q000401:mortality / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000276:immunology / Q000401:mortality / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D059951:HLA-G Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D054643:INDEL Mutation; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis
D059951:HLA-G Antigens
Breast cancer; HLA-G; Polymorphism; Tumor escape