Coding odor identity and odor value in awake rodents.
In the last decade, drastic changes in the understanding of the role of the olfactory bulb and piriform cortex in odor detection have taken place through awake behaving recording in rodents. It is clear that odor responses in mitral and granule cells are strikingly different in the olfactory bulb of anesthetized versus awake animals. In addition, sniff recording has evidenced that mitral cell responses to odors during the sniff can convey information on the odor identity and sniff phase. Moreover, we review studies that show that the mitral cell conveys information on not only odor identity but also whether the odor is rewarded or not (odor value). Finally, we discuss how the substantial increase in awake behaving recording raises questions for future studies.
Department of Cell and Developmental Biology, Rocky Mountain Taste and Smell Center and Neuroscience Program, University of Colorado Medical School, Aurora, CO, USA.
Alexia
A
Nunez-Parra
Department of Cell and Developmental Biology, Rocky Mountain Taste and Smell Center and Neuroscience Program, University of Colorado Medical School, Aurora, CO, USA; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan, China.
Anan
A
Li
Department of Cell and Developmental Biology, Rocky Mountain Taste and Smell Center and Neuroscience Program, University of Colorado Medical School, Aurora, CO, USA. Electronic address: Diego.Restrepo@ucdenver.edu.
Diego
D
Restrepo
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D009415:Nerve Net / Q000502:physiology; D009812:Odorants; D009830:Olfactory Bulb / Q000166:cytology / Q000502:physiology*; D009833:Olfactory Pathways / Q000502:physiology*; D012377:Rodentia; D011984:Sensory Receptor Cells / Q000502:physiology; D012903:Smell / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
anesthetized; awake behaving; olfaction; olfactory bulb; piriform cortex; sniff