Specific features of analgesic effect of docosahexaenoic acid in rats with neuropathic pain syndrome.
Experiments on white rats showed that sciatic nerve ligation induced the development of neuropathic pain syndrome: thermal pain threshold decreased, significant reduction in weight bearing of the injured limb, and degenerative changes in the foot tissues. Administration of docosahexaenoic acid reduces activity and duration neuropathic pain syndrome, promoted reversion of weight bearing asymmetry, and prevented the development of degenerative changes in the foot tissues.
A. V. Zhirmunskii Institute of Marine Biology, Far Eastern Division of Russian Academy of Sciences, Vladivostok, Russia.
I V
IV
Dyuizen
I V
IV
Manzhulo
O S
OS
Ogurtsova
N E
NE
Lamash
N A
NA
Latyshev
S V
SV
Kas'yanov
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004281:Docosahexaenoic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005121:Extremities / Q000503:physiopathology; D006930:Hyperalgesia / Q000188:drug therapy*; D008297:Male; D009437:Neuralgia / Q000188:drug therapy*; D017207:Rats, Sprague-Dawley; D016474:Weight-Bearing
D018712:Analgesics, Non-Narcotic; D004281:Docosahexaenoic Acids