TWIST overexpression predicts biochemical recurrence-free survival in prostate cancer patients treated with radical prostatectomy.
OBJECTIVE
The aim of this study was to determine whether TWIST and androgen receptor (AR) expression can predict the outcome in radical prostatectomy (RP) patients.


METHODS
Samples from different tumour areas of 181 prostate cancer patients were analysed for TWIST and AR expression, and the results were correlated with known clinicopathological data and biochemical recurrence-free survival (BFS).


RESULTS
TWIST overexpression in the margin area of the tumour (M-TWIST) was related to positive surgical margin (p = 0.047), capsule invasion (p = 0.006) and biochemical recurrence (BCR) (p = 0.004). AR expression in the margin area of the tumour (M-AR) was associated with high Gleason score (p = 0.004), positive surgical margin (p = 0.004) and BCR (p = 0.05). M-TWIST overexpression was clearly associated with M-AR expression (p < 0.0001). Four parameters, i.e. M-TWIST overexpression (p < 0.0001), positive surgical margin (p = 0.003), high Gleason score (p < 0.0001) and M-AR expression (p = 0.008), predicted BFS. In the multivariate analysis, M-TWIST overexpression (p = 0.011) and Gleason score (p = 0.002) were the only independent predictors of BFS.


CONCLUSIONS
M-TWIST overexpression is associated with clinicopathological prognosis factors and M-AR overexpression and is a powerful independent predictor of BFS in conjunction with the Gleason score in prostate cancer patients treated with RP.
Departments of 1Surgery and.
Sami
S
Raatikainen
Sirpa
S
Aaltomaa
Jorma J
JJ
Palvimo
Vesa
V
Kärjä
Ylermi
Y
Soini
D000368:Aged; D015331:Cohort Studies; D018572:Disease-Free Survival; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000378:metabolism*; D018365:Neoplasm, Residual; D009687:Nuclear Proteins / Q000378:metabolism*; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D011944:Receptors, Androgen / Q000378:metabolism*; D012189:Retrospective Studies; D051879:Twist-Related Protein 1 / Q000378:metabolism*
D009687:Nuclear Proteins; D011944:Receptors, Androgen; C103173:TWIST1 protein, human; D051879:Twist-Related Protein 1; D017430:Prostate-Specific Antigen
TWIST; androgen receptor; prognosis; prostate cancer; radical prostatectomy