An update on vaccines against Shigella.
Despite intensive research efforts for more than 60 years, utilizing diverse vaccine strategies, a safe and efficacious vaccine against shigellosis is not available yet. We are currently witnessing innovative approaches based on elucidation of the virulence mechanisms of Shigella, understanding the immune response to the pathogen and progress in molecular technology for developing Shigella vaccines. It is hoped that these will lead to a licensed effective Shigella vaccine to protect humans against the significant worldwide morbidity and mortality caused by this microorganism.
Department of Pediatrics A, Schneider Children's Medical Center, 14 Kaplan Street, Petach Tikva 49202, Israel.
Shai
S
Ashkenazi
School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Dani
D
Cohen
Shigellosis; diarrhea; gastroenteritis; prevention; vaccine