Carboxymethylcellulose adhesion barrier placement at primary cesarean delivery and outcomes at repeat cesarean delivery.
OBJECTIVE
To assess associations of a commercially available carboxymethylcellulose adhesion barrier placed during primary cesarean delivery with clinical outcomes of repeat cesarean deliveries.


METHODS
We performed a retrospective cohort study of women undergoing primary cesarean delivery on or after January 1, 2008, and first repeat cesarean delivery in one of four hospitals in the same system by June 30, 2011. Women were included if both deliveries were live singletons at 34-42 weeks of gestation delivered through transverse abdominal incisions and the first hysterotomy was low transverse. Exclusion criteria included intervening delivery; puerperal infection, bowel injury, or bladder injury at primary cesarean delivery; uterine incision or laparotomy (except primary cesarean delivery) before repeat cesarean delivery; and use of another adhesion barrier at primary cesarean delivery. As a surrogate for adhesion grading, the primary outcome was time from skin incision to neonate delivery at repeat cesarean delivery. We also assessed total operative time and rates of selected surgical complications.


RESULTS
There were 517 women who met criteria; 248 received the adhesion barrier during primary cesarean delivery and 269 did not. There were no demographic differences between groups except delivery hospital. In the adhesion barrier and no adhesion barrier groups, respectively, mean±standard deviation times to delivery at repeat cesarean delivery were 6.1±3.0 compared with 5.8±2.5 minutes (P=.25), and total operative times were 31.2±10.6 compared with 31.8±11.6 minutes (P=.56). Surgical complications were not different between groups.


CONCLUSIONS
Placing a commercially available carboxymethylcellulose adhesion barrier at primary cesarean delivery is not associated with decreased time to delivery, total operative time, or complications during repeat cesarean deliveries.


METHODS
II.
University of Alabama Birmingham School of Medicine, the Center for Women's Reproductive Health, Birmingham, Alabama; and Phoenix Perinatal Associates, a Division of Obstetrix Medical Group, Mednax, Inc, and the Department of Internal Medicine, Banner Good Samaritan Medical Center, Phoenix, Arizona.
Rodney K
RK
Edwards
Melissa
M
Ingersoll
Richard D
RD
Gerkin
Ana V
AV
Bodea-Braescu
Monique G
MG
Lin
D000328:Adult; D016063:Blood Loss, Surgical; D015992:Body Mass Index; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D002585:Cesarean Section / Q000009:adverse effects / Q000379:methods*; D017604:Cesarean Section, Repeat / Q000009:adverse effects; D004337:Drug Carriers / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D061646:Operative Time; D012189:Retrospective Studies; D013536:Suture Techniques; D013997:Time Factors; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*; D055815:Young Adult
D004337:Drug Carriers; D002266:Carboxymethylcellulose Sodium