[Studies on pharmacokinetics features of characteristic active ingredients of daidai flavone extract in different physiological status].
In order to explore the clinical hypolipidemic features of Daidai flavone extract, the pharmacokinetics features of characteristic active ingredients of Daidai flavone extract in normal and hyperlipemia rats were studied and compared. The study established the quantitative determination method of naringin and neohesperidin in plasma by UPLC-MS. Study compared the pharmacokinetics differences of naringin and noehesperidin in normal and hyperlipemia rats on the basis of establishment of hyperlipemia model. Results indicated that the pharmacokinetics features of characteristic active ingredients of Daidai flavone extract in normal and hyperlipemia rats showed significant differences. The C(max) of naringin and neohesperidin in hyperlipemia rats plasma after oral administration of Daidai flavone extract increased obviously, while t1/2, MRT and AUC0-24 h decreased, compared to normal rats. But t(max) showed no differences to that of normal rats. The results further proved Daidai flavone extract would have better hypolipidemic effect in the hyperlipemia pathological status. And the characteristic active ingredients naringin and noehesperidin were the material base of Daidai flavone extract to express the hypolipidemic effect.
Ling-Jun
LJ
Zeng
Dan
D
Chen
Li
L
Zheng
Yun-Fang
YF
Lian
Wei-Wei
WW
Cai
Qun
Q
Huang
Yi-Li
YL
Lin
D000818:Animals; D002957:Citrus / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification* / Q000493:pharmacokinetics*; D047309:Flavones / Q000737:chemistry*; D006949:Hyperlipidemias / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D047309:Flavones