The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue.
We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds - 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid - to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes.
Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Vladimir I
VI
Potkin
Dzmitry
D
Shcharbin
Andrey A
AA
Denisov
Svetlana G
SG
Paschkevich
Maria
M
Bryszewska
Sergey K
SK
Petkevich
Alexey V
AV
Kletskov
Dmitri O
DO
Lapotko
Vladimir V
VV
Kazbanov
Tatiana A
TA
Gurinovich
Vladimir A
VA
Kulchitsky
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002264:Carboxylic Acids / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry / Q000494:pharmacology*; D055724:Electrophysiological Phenomena / Q000187:drug effects; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D000860:Hypoxia; D066298:In Vitro Techniques; D007555:Isoxazoles / Q000737:chemistry*; D008297:Male; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry
C000595247:1-(6-hydroxyhexyl)-3-(5-phenylisoxazole-3-yl)urea; C550869:5-phenylisoxazole-3-carboxylic acid; D002264:Carboxylic Acids; D050091:Dendrimers; D007555:Isoxazoles; C104700:PAMAM Starburst; D014508:Urea; D010100:Oxygen