Regulators help new immigrants settle down?
In this issue of Blood, Müller et al showed, using a nonmyeloablative conditioning regimen consisting of total lymphoid irradiation (TLI) and anti-T-cell globulin (ATG), that donor long-term hematopoietic stem cell (LT-HSC) engraftment requires the presence of host regulatory T cells that promote host HSC cycling, which could potentially provide bone marrow niches to donor HSCs.
THE BECKMAN RESEARCH INSTITUTE OF CITY OF HOPE.
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D000818:Animals; D006085:Graft Survival / Q000276:immunology*; D006410:Hematopoiesis / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D019172:Transplantation Conditioning / Q000379:methods*