Effect of ZrO(2) additions on the crystallization, mechanical and biological properties of MgO-CaO-SiO(2)-P(2)O(5)-CaF(2) bioactive glass-ceramics.
A series of ZrO(2) doped MgO-CaO-SiO(2)-P(2)O(5)-CaF(2) bioactive glass-ceramics were obtained by sintering method. The crystallization behavior, phase composition, morphology and structure of glass-ceramics were characterized. The bending strength, elastic modulus, fracture toughness, micro-hardness and thermal expansion coefficient (TEC) of glass-ceramics were investigated. The in vitro bioactivity and cytotoxicity tests were used to evaluate the bioactivity and biocompatibility of glass-ceramics. The sedimentation mechanism and growth process of apatites on sample surface were discussed. The results showed that the mainly crystalline phases of glass-ceramics were Ca(5)(PO4)3F (fluorapatite) and β-CaSiO(3). (β-wollastonite). m-ZrO(2) (monoclinic zirconia) declined the crystallization temperatures of glasses. t-ZrO(2) (tetragonal zirconia) increased the crystallization temperature of Ca(5)(PO4)(3)F and declined the crystallization temperature of β-CaSiO(3). t-ZrO(2) greatly increased the fracture toughness, bending strength and micro-hardness of glass-ceramics. The nanometer apatites were induced on the surface of glass-ceramic after soaking 28 days in SBF (simulated body fluid), indicating the glass-ceramic has good bioactivity. The in vitro cytotoxicity test demonstrated the glass-ceramic has no toxicity to cell.
Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials, Ministry of Education, Shandong University, Shandong, Ji'nan 250061, People's Republic of China; School of Materials Science and engineering, Shandong University, Shandong, Ji'nan 250061, People's Republic of China. Electronic address: lihuancai1988@sina.com.
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Li
Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials, Ministry of Education, Shandong University, Shandong, Ji'nan 250061, People's Republic of China; School of Materials Science and engineering, Shandong University, Shandong, Ji'nan 250061, People's Republic of China. Electronic address: wangdg@sdu.edu.cn.
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Wang
Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials, Ministry of Education, Shandong University, Shandong, Ji'nan 250061, People's Republic of China; School of Materials Science and engineering, Shandong University, Shandong, Ji'nan 250061, People's Republic of China. Electronic address: xgmengsdu@163.com.
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Meng
Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials, Ministry of Education, Shandong University, Shandong, Ji'nan 250061, People's Republic of China; School of Materials Science and engineering, Shandong University, Shandong, Ji'nan 250061, People's Republic of China. Electronic address: czchen@sdu.edu.cn.
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Chen
D000818:Animals; D001826:Body Fluids / Q000737:chemistry; D017610:Calcium Compounds / Q000737:chemistry / Q000494:pharmacology; D002124:Calcium Fluoride / Q000737:chemistry / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D002516:Ceramics / Q000737:chemistry* / Q000494:pharmacology*; D003460:Crystallization; D004055:Differential Thermal Analysis; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D008277:Magnesium Oxide / Q000737:chemistry / Q000494:pharmacology; D055595:Mechanical Phenomena; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010087:Oxides / Q000737:chemistry / Q000494:pharmacology; D017553:Phosphorus Compounds / Q000737:chemistry / Q000494:pharmacology; D012822:Silicon Dioxide / Q000737:chemistry / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014961:X-Ray Diffraction; D015040:Zirconium / Q000494:pharmacology*
D017610:Calcium Compounds; D010087:Oxides; D017553:Phosphorus Compounds; D008277:Magnesium Oxide; C012500:phosphorus pentoxide; D012822:Silicon Dioxide; C023506:Glass ceramics; D015040:Zirconium; C016538:lime; D002124:Calcium Fluoride; C028541:zirconium oxide
Bioactivity; Biocompatibility; Glass-ceramic; Mechanical properties; ZrO(2)