Fumaric acid esters in psoriasis and multiple sclerosis.
Fumaric acid esters (FAEs) are effective in patients with moderate to severe psoriasis. Recent studies also report the efficacy of one FAE component, dimethylfumarate, in relapsing forms of multiple sclerosis (MS). We describe the case of a patient with MS who developed severe plaque psoriasis during interferon-β-1a treatment for MS. The psoriasis was unresponsive to usual topical treatments and phototherapy. The patient was started on FAE 720 mg daily, with complete remission of the psoriatic lesions and neurological stabilization at follow-up at 24 months. Our case suggests that FAEs could represent a therapeutic option for patients with MS who develop plaque psoriasis following exposure to immune-modulating agents.
Department of Neurology, Neurocenter of Southern Switzerland, Ospedale Regionale, Lugano, Switzerland.
C
C
Zecca
M
M
Caporro
M
M
Adami
C
C
Mainetti
C
C
Gobbi
D000276:Adjuvants, Immunologic / Q000009:adverse effects; D003875:Drug Eruptions / Q000188:drug therapy*; D004952:Esters; D005650:Fumarates / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy*; D011565:Psoriasis / Q000139:chemically induced / Q000188:drug therapy*; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D004952:Esters; D005650:Fumarates; D007166:Immunosuppressive Agents; D016899:Interferon-beta; D000068556:Interferon beta-1a