Effects of paliperidone palmitate on coagulation: an experimental study.
OBJECTIVE
The aim of the present study was to examine the effects of a new antipsychotic drug paliperidone palmitate on hemogram and coagulation parameters in rats.


METHODS
Experiments were performed on 22 female albino Wistar rats (8-12 weeks old). Control group was given drinking water as vehicle (0.3 mL). PAL-1 rats were given 1 mg/kg paliperidone palmitate (in 0.3 mL drinking water) by oral gavage once a day for ten days and PAL-3 rats received 3 mg/kg paliperidone palmitate (in 0.3 mL drinking water) by oral gavage for ten days. Blood samples were drawn from the heart 24 hours after the last drug dose, and hemogram and coagulation parameters were measured with automated analyzers.


RESULTS
Hemogram did not change in the paliperidone treated groups compared to the controls. Factor VIII levels decreased in the PAL-1 and PAL-3 groups; and this decrease was significantly greater in the PAL-3. Factor IX levels decreased in PAL-3 rats, but its levels also increased in PAL-1 rats compared to the control.


CONCLUSIONS
Paliperidone has led to changes in the serum levels of coagulation factors VIII and IX in rats. As a result, paliperidone may be causing thromboembolism or bleeding in a dose-independent manner.
Department of Psychiatry, Faculty of Medicine, Bezmialem University, Istanbul, Turkey.
Enver Demirel
ED
Yılmaz
Department of Biochemistry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Sedat
S
Motor
Department of Physiology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Fatih
0000-0001-5534-7448
F
Sefil
Department of Pharmacology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Neslihan
N
Pınar
Department of Psychiatry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Hanifi
H
Kokacya
Department of Pharmacology, Faculty of Medicine, Mevlana University, Konya, Turkey.
Mustafa
M
Kisa
Department of Pharmacology, Faculty of Medicine, Mevlana University, Konya, Turkey.
Suleyman
S
Oktar
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D004909:Erythrocyte Indices / Q000187:drug effects; D005260:Female; D007555:Isoxazoles / Q000008:administration & dosage / Q000494:pharmacology*; D000068882:Paliperidone Palmitate; D010168:Palmitates / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D014150:Antipsychotic Agents; D007555:Isoxazoles; D010168:Palmitates; D000068882:Paliperidone Palmitate