Antioxidant and antitumor activities of new synthesized aromatic C-nucleoside derivatives.
The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as the key intermediate for synthesis of 1,3,4-oxadiazole  and 1,2,4-triazole-3-thione derivatives 21 and 23. The antioxidant activities of the prepared compounds were evaluated. The carbohydrazide 1 in particular was found to have potent antioxidant and antitumor activity.
Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt. mohamed.elsadik@alexu.edu.eg.
Mohamed M
MM
El Sadek
Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt. nagwa_abdeldayem@yahoo.com.
Nagwa S
NS
Abd El-Dayem
Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt. sehamyassen@yahoo.com.
Seham Y
SY
Hassan
Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt. dr_abdel_zaher@hotmail.com.
Mohamed A
MA
Mostafa
Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt. galila_69@yahoo.com.
Galila A
GA
Yacout
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D006834:Hydrazines / Q000737:chemistry; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010069:Oxadiazoles / Q000737:chemistry; D010851:Picrates / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry
D000970:Antineoplastic Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D006834:Hydrazines; D009705:Nucleosides; D010069:Oxadiazoles; D010851:Picrates; D013882:Thiosemicarbazones; D014230:Triazoles; C004931:1,1-diphenyl-2-picrylhydrazyl; C019289:carbohydrazide