Closed-loop artificial pancreas systems: physiological input to enhance next-generation devices.
To provide an understanding of both the preclinical and clinical aspects of closed-loop artificial pancreas systems, we provide a discussion of this topic as part of this two-part Bench to Clinic narrative. Here, the Bench narrative provides an in-depth understanding of insulin-glucose-glucagon physiology in conditions that mimic the free-living situation to the extent possible in type 1 diabetes that will help refine and improve future closed-loop system algorithms. In the Clinic narrative, Doyle and colleagues compare and evaluate technology used in current closed-loop studies to gain further momentum toward outpatient trials and eventual approval for widespread use.
Corresponding author: Ananda Basu, basu.ananda@mayo.edu.
Yogish C
YC
Kudva
Rickey E
RE
Carter
Claudio
C
Cobelli
Rita
R
Basu
Ananda
A
Basu
D000465:Algorithms; D001786:Blood Glucose / Q000378:metabolism; D002940:Circadian Rhythm / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology / Q000628:therapy*; D004435:Eating / Q000502:physiology; D015444:Exercise / Q000502:physiology; D005934:Glucagon / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000517:prevention & control; D007003:Hypoglycemia / Q000209:etiology / Q000517:prevention & control; D007328:Insulin / Q000378:metabolism; D007332:Insulin Infusion Systems / Q000639:trends*; D019397:Pancreas, Artificial / Q000639:trends*; D013315:Stress, Psychological / Q000503:physiopathology
D001786:Blood Glucose; D012739:Gonadal Steroid Hormones; D007328:Insulin; D005934:Glucagon