An enantioselective cascade reaction between α,β-unsaturated aldehydes and malonic half-thioesters: a rapid access to chiral δ-lactones.
We disclose a novel efficient enantioselective organocatalytic cascade reaction for the preparation of δ-lactones in good to excellent yields (69-93%) and with high to excellent enantioselectivities (88-96% ee).
Hubei Collaborative Innovation Centre for Non-power Nuclear Technology, College of Chemistry and Biological Sciences, Hubei University of Science and Technology, Hubei Province 437100, People's Republic China.
Qiao
Q
Ren
Shaofa
S
Sun
Jiayao
J
Huang
Wenjun
W
Li
Minghu
M
Wu
Haibing
H
Guo
Jian
J
Wang
D000447:Aldehydes / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008314:Malonates / Q000737:chemistry*; D008968:Molecular Conformation; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D000447:Aldehydes; D007783:Lactones; D008314:Malonates; D013438:Sulfhydryl Compounds; C030290:malonic acid