Primary diffuse leptomeningeal glioneuronal tumors.
Diffuse leptomeningeal disseminated glioneuronal tumor (DL-GNT) is a rare brain tumor that presents as a plaque-like subarachnoid tumor, commonly involving the basal cisterns and interhemispheric fissure of children but lacking intraparenchymal tumor. Histologically, the tumors are composed of sheets of monotonous rounded cells. Here, we report three cases of DL-GNTs, focusing on clinicopathologic features. Two patients were adult male, but one patient was child. The patients presented with seizures (n = 1) or headaches (n = 2). In all patients, radiography revealed characteristic leptomeningeal thickening and enhancement with minor superficial parenchymal lesions. All three cases were diffusely positive for both GFAP and synaptophysin, and scattered positive for OLIG2 and NeuN, but negative for IDH-1 (H09). Electron microscopic examination showed astrocytic and neuronal differentiation. The patient with the anaplastic tumor died due to aggressive progression of the tumor, but the remaining two patients were stable without tumor recurrence for 23 and 37 months. Thus, these findings suggest that DL-GNT can occur in both children and adult and both supra- and infra-tentorial leptomeninges. It has unique radiological and histopathological features and biological behavior. Further clinicopathological data with molecular genetic study are required for establishing DL-GNT as a unique entity.
Department of Pathology, Seoul National University Hospital, College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea.
Hwa Jin
HJ
Cho
Jae Kyung
JK
Myung
Hannah
H
Kim
Chul-Kee
CK
Park
Sung-Ki
SK
Kim
Chun Kee
CK
Chung
Seung-Hong
SH
Choi
Sung-Hye
SH
Park
D000328:Adult; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D018303:Ganglioglioma / Q000175:diagnosis* / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D009457:Neuroglia / Q000473:pathology*; D013120:Spinal Cord Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000648:ultrastructure; D055815:Young Adult