Contribution of the Retrovirus Epidemiology Donor Study (REDS) to research on blood transfusion safety in Brazil.
The Retrovirus Epidemiology Donor Study (REDS) program was established in the United States in 1989 with the purpose of increasing blood transfusion safety in the context of the HIV/AIDS and human T-lymphotropic virus epidemics. REDS and its successor, REDS-II were at first conducted in the US, then expanded in 2006 to include international partnerships with Brazil and China. In 2011, a third wave of REDS renamed the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) was launched. This seven-year research program focuses on both blood banking and transfusion medicine research in the United States of America, Brazil, China, and South Africa. The main goal of the international programs is to reduce and prevent the transmission of HIV/AIDS and other known and emerging infectious agents through transfusion, and to address research questions aimed at understanding global issues related to the availability of safe blood. This article describes the contribution of REDS-II to transfusion safety in Brazil. Articles published from 2010 to 2013 are summarized, including database analyses to characterize blood donors, deferral rates, and prevalence, incidence and residual risk of the main blood-borne infections. Specific studies were developed to understand donor motivation, the impact of the deferral questions, risk factors and molecular surveillance among HIV-positive donors, and the natural history of Chagas disease. The purpose of this review is to disseminate the acquired knowledge and briefly summarize the findings of the REDS-II studies conducted in Brazil as well as to introduce the scope of the REDS-III program that is now in progress and will continue through 2018.
Universidade de Pernambuco, Faculdade de Ciências Médicas, Recife, PE, Brazil, Faculdade de Ciências Médicas, Universidade de Pernambuco (UPE), Recife, PE, Brazil ; Fundação Hemope, Recife, PE, Brazil, Fundação Hemope, Recife, PE, Brazil.
Paula
P
Loureiro
Fundação Pró-Sangue, Hemocentro de São Paulo, São Paulo, SP, Brazil, Fundação Pró-Sangue - Hemocentro de São Paulo, São Paulo, SP, Brazil.
Cesar
C
de Almeida-Neto
Fundação Hemominas, Belo Horizonte, MG, Brazil, Fundação Hemominas, Belo Horizonte, MG, Brazil.
Anna Bárbara Carneiro
AB
Proietti
Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP, Brazil, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Ligia
L
Capuani
Blood System Research Institute, San Francisco, California, USA, Blood System Research Institute, San Francisco, California, USA.
Thelma Terezinha
TT
Gonçalez
Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Claudia Di Lorenzo
CD
de Oliveira
Fundação Hemope, Recife, PE, Brazil, Fundação Hemope, Recife, PE, Brazil.
Silvana Carneiro
SC
Leão
Fundação Hemope, Recife, PE, Brazil, Fundação Hemope, Recife, PE, Brazil.
Maria Inês
MI
Lopes
Universidade de Pernambuco, Faculdade de Ciências Médicas, Recife, PE, Brazil, Faculdade de Ciências Médicas, Universidade de Pernambuco (UPE), Recife, PE, Brazil ; Fundação Hemope, Recife, PE, Brazil, Fundação Hemope, Recife, PE, Brazil.
Divaldo
D
Sampaio
Fundação Pró-Sangue, Hemocentro de São Paulo, São Paulo, SP, Brazil, Fundação Pró-Sangue - Hemocentro de São Paulo, São Paulo, SP, Brazil.
Giuseppina Maria
GM
Patavino
Universidade de São Paulo, Instituto de Matemática e Estatística, São Paulo, SP, Brazil, Instituto de Matemática e Estatística, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
João Eduardo
JE
Ferreira
Fundação Pró-Sangue, Hemocentro de São Paulo, São Paulo, SP, Brazil, Fundação Pró-Sangue - Hemocentro de São Paulo, São Paulo, SP, Brazil.
Paula Fraiman
PF
Blatyta
Fundação Hemorio, Rio de Janeiro, RJ, Brazil, Fundação Hemorio, Rio de Janeiro, RJ, Brazil.
Maria Esther Duarte
ME
Lopes
Fundação Pró-Sangue, Hemocentro de São Paulo, São Paulo, SP, Brazil, Fundação Pró-Sangue - Hemocentro de São Paulo, São Paulo, SP, Brazil.
Alfredo
A
Mendrone-Junior
Fundação Pró-Sangue, Hemocentro de São Paulo, São Paulo, SP, Brazil, Fundação Pró-Sangue - Hemocentro de São Paulo, São Paulo, SP, Brazil.
Nanci Alves
NA
Salles
Westat, Rockville, Maryland, USA, Westat, Rockville, Maryland, USA.
Melissa
M
King
University of California San Francisco, California, USA, University of California San Francisco, California, USA.
Edward
E
Murphy
Blood System Research Institute, San Francisco, California, USA, Blood System Research Institute, San Francisco, California, USA.
Michael
M
Busch
Blood System Research Institute, San Francisco, California, USA, Blood System Research Institute, San Francisco, California, USA.
Brian
B
Custer
Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP, Brazil, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Ester Cerdeira
EC
Sabino
Blood donation; Blood-borne infectious diseases; Transfusion safety