Mueller matrix decomposition for determination of optical rotation of glucose molecules in turbid media.
The optical activity of glucose molecules is important for diagnosing and monitoring blood glucose of diabetes. In order to accurately detect the diabetes at an early stage, there is an urgent need to develop innovative detection methods. By use of Mueller matrix decomposition (MMD), we have studied the optical activity of glucose molecules in three types of turbid media--polystyrene (PST) sphere suspension, chicken blood, and the vein blood of diabetic patients. The experimental setup to obtain the Mueller matrix in the forward detection geometry has been used. The experimental results show that the rotation angle has linear relationship with the concentration of the glucose when the scattering coefficient of the PST sphere suspension remains unchanged, whereas the scattering effect enlarges the rotation angle. Furthermore, optical rotation abides by Drude's dispersion equation. The decomposition method has also been found useful applications in quantifying the optical rotations of blood glucose in diabetic patients. The diabetic severity status can be distinguished with the rotation angle of glucose and also is in accordance with the clinical diagnosis. Thus, the method of MMD has promising applications in diabetic diagnosis and monitoring.
Beijing Normal University, Department of Physics, Beijing Area Major Laboratory of Applied Optics, Beijing 100875, China.
Ping
P
Sun
Beijing Normal University, Department of Physics, Beijing Area Major Laboratory of Applied Optics, Beijing 100875, China.
Yongchao
Y
Ma
Capital Normal University, Department of Physics, Beijing 100048, China.
Wei
W
Liu
Beijing Normal University, Department of Physics, Beijing Area Major Laboratory of Applied Optics, Beijing 100875, China.
Qinghua
Q
Yang
Beijing Normal University, Department of Physics, Beijing Area Major Laboratory of Applied Optics, Beijing 100875, China.
Qiongzhen
Q
Jia
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000818:Animals; D001774:Blood Chemical Analysis / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis* / Q000737:chemistry*; D002645:Chickens; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008956:Models, Chemical; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D009904:Optical Rotation; D011137:Polystyrenes / Q000737:chemistry
D001786:Blood Glucose; D011137:Polystyrenes