A concise approach to polysubstituted oxazoles from N-acyl-2-bromo enamides via a copper(I)/amino acid-catalyzed intramolecular C-O bond formation.
A straightforward and efficient copper(I)/amino acid-catalyzed intramolecular Ullmann-type C-O coupling reaction has been developed. This protocol affords a facile methodology for the synthesis of a series of novel 2,4,5-substituted oxazoles from readily accessible N-acyl-2-bromo enamides under mild conditions.
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan Province 450001, China. changjunbiao@zzu.edu.cn wenquan_yu@zzu.edu.cn.
Bingjie
B
Liu
Yueteng
Y
Zhang
Gang
G
Huang
Xinting
X
Zhang
Pengfei
P
Niu
Jie
J
Wu
Wenquan
W
Yu
Junbiao
J
Chang
D000577:Amides / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000577:Amides; D000596:Amino Acids; D010080:Oxazoles; D003300:Copper