Linker-determined drug release mechanism of free camptothecin from self-assembling drug amphiphiles.
We report here that the release mechanism of free camptothecin from self-assembling drug amphiphiles can be regulated by use of different linker groups. Our results highlight the significance of the linker group of drug amphiphiles on the drug release efficiency and their consequent in vitro efficacy.
Department of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology (INBT), The Johns Hopkins University, Baltimore, MD 21218, USA. hcui6@jhu.edu.
Andrew G
AG
Cheetham
Yu-Chuan
YC
Ou
Pengcheng
P
Zhang
Honggang
H
Cui
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D002166:Camptothecin / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D065546:Drug Liberation; D005260:Female; D006801:Humans; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D011355:Prodrugs / Q000737:chemistry*; D016875:tau Proteins / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D011355:Prodrugs; D016875:tau Proteins; D002166:Camptothecin