Paget's disease of bone.
Paget's disease of bone is a common disorder characterized by increased but disorganized bone remodelling. Some patients are asymptomatic but others present with bone pain or other complications such as fracture and deformity. Major advances have been made in understanding the pathophysiology of Paget's disease in recent years and highly effective agents are now available with which to suppress the abnormal bone turnover that causes the disease. Here we review recent advances in the epidemiology, pathogenesis, clinical features and management of Paget's disease. We also reflect upon the future challenges that remain to be overcome to explain the unusual distribution of the disease and to favourably alter the natural history and prevent the development of complications.
From the Rheumatic Diseases Unit and Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK.
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From the Rheumatic Diseases Unit and Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK From the Rheumatic Diseases Unit and Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK stuart.ralston@ed.ac.uk.
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Ralston
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D016723:Bone Remodeling / Q000502:physiology; D004781:Environmental Exposure / Q000009:adverse effects; D005544:Forecasting; D005598:Fractures, Spontaneous / Q000209:etiology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D059352:Musculoskeletal Pain / Q000209:etiology; D009154:Mutation / Q000235:genetics; D010001:Osteitis Deformans / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D053244:Osteoprotegerin / Q000235:genetics; D017410:Practice Guidelines as Topic; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000235:genetics; D000071456:Sequestosome-1 Protein
D048868:Adaptor Proteins, Signal Transducing; D050071:Bone Density Conservation Agents; D053244:Osteoprotegerin; D053246:Receptor Activator of Nuclear Factor-kappa B; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein; C505686:TNFRSF11A protein, human; C506030:TNFRSF11B protein, human