The 25th anniversary of the launch of Prozac gives pause for thought: where did we go wrong?
The creation, in DSM-III, of the category 'major depression' can be linked to the launch, and success, of Prozac. The consequences of creating this broad diagnostic category are of concern in relation to the treatment of individuals with a diverse variety of depressive disorders.
Edward Shorter, PhD, FRSC, History of Medicine Program, University of Toronto, 207-88 College Street, Toronto M5G 1L7, Canada. Email: history.medicine@utoronto.ca.
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D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans
D000928:Antidepressive Agents; D005473:Fluoxetine