[A case of urachal carcinoma with multiple lung metastases treated by TS-1/CDDP chemotherapy].
A 67-year-old woman presented with macroscopic hematuria and lower abdominal pain. Cystoscopy revealed a broad-stalk non-papillary tumor at the bladder dome. Computed tomography (CT) showed a tumor extending from the umbilicus to the bladder dome, together with multiple lung metastases. Serum carcinoembryonic antigen and cancer antigen (CA19-9) levels were elevated at 7.0 ng/ml and 180 U/ml, respectively. Transurethral resection of the tumor was performed and histopathology revealed adenocarcinoma. Therefore, the tumor was diagnosed as a stage IVB (Sheldon's category) urachal carcinoma. En bloc segmental resection of the urachal carcinoma with the bladder dome was performed, followed by chemotherapy with tegafur, gimestat, and otastat potassium (TS-1) and cisplatin. The disease remained stable for 8 months. However, a follow up CT scan after 11 chemotherapy cycles showed progression of the lung metastases. In spite of the change to a second-line gemcitabine and cisplatin chemotherapy regimen, the disease continued to progress after 4 cycles.
The Department of Urology, Hyogo Prefectural Nishinomiya Hospital.
Yasuyuki
Y
Yoshida
The Department of Specific Organ Regulation (Urology), Osaka University.
Kazuaki
K
Yamanaka
The Department of Urology, Hyogo Prefectural Nishinomiya Hospital.
Norichika
N
Ueda
The Department of Urology, Hyogo Prefectural Nishinomiya Hospital.
Toshiaki
T
Hirai
The Department of Urology, Hyogo Prefectural Nishinomiya Hospital.
Hidefumi
H
Kishikawa
The Department of Urology, Hyogo Prefectural Nishinomiya Hospital.
Kenji
K
Nishimura
The Department of Urology, Hyogo Prefectural Nishinomiya Hospital.
Yasuji
Y
Ichikawa
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology*; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002272:Carcinoembryonic Antigen / Q000097:blood; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D010094:Oxonic Acid / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology*
D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; D004338:Drug Combinations; C578959:carbohydrate antigen 199, human; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid