Transplanted tumor growth inhibition by functionalized short single-walled carbon nanotubules.
The effects of short single-walled carbon nanotubules functionalized by COOH- and NH2- containing groups (NT-COOH and NT-NH2), on the dynamics of transplanted Pliss lymphosarcoma growth were studied after tumor cell preincubation with nanotubules and after injection of nanotubules into the developing tumor. Tumor growth was inhibited and the lifespan of rats with tumors was prolonged by 1.7 times after transplantation of tumor preincubated with NT-NH2, while NT-COOH caused no effect of this kind. Intratumor injection of NT-NH2 inhibited tumor growth over 3 weeks and prolonged animal lifespan.
Rostov Research Oncological Institute, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
O I
OI
Kit
E Yu
EY
Zlatnik
L V
LV
Peredreyeva
S P
SP
Chervonobrodov
D000818:Animals; D002455:Cell Division; D064593:Heterografts; D006801:Humans; D037742:Nanotubes, Carbon; D009369:Neoplasms / Q000473:pathology*; D051381:Rats
D037742:Nanotubes, Carbon