Assessment of hupu gum for its carrier property in the design and evaluation of solid mixtures of poorly water soluble drug - rofecoxib.
There are no reports about the pharmaceutical applications of hupu gum (HG). Hence the present study was undertaken to test its suitability in the dissolution enhancement of poorly water soluble drug. Rofecoxib (RFB) was taken as model drug. For comparison solid mixtures were prepared with carriers such as poly vinyl pyrrolidone (PVP), sodium starch glycollate (SSG) and guar gum (GG). Physical mixing (PM), co-grinding (CG), kneading (KT) and solvent evaporation (SE) techniques were used to prepare the solid mixtures, using all the carriers in different carrier and drug ratios. The solid mixtures were characterized by powder X-ray diffraction (XRD) and Fourier-transformed infrared spectroscopy (FTIR). There was a significant improvement in the dissolution rate of solid mixtures of HG, when compared with the solid mixtures of other carriers. There was an increase in dissolution rate with increase in concentration of HG upto 1:1 ratio of carrier and drug. No drug-carrier interaction was found by FTIR studies. XRD studies indicated reduction in crystallinity of the drug with increase in HG concentration. Hence HG could be a useful carrier for the dissolution enhancement of poorly water soluble drugs.
Harini Chowdary
HC
Vadlamudi
Y Prasanna
YP
Raju
G
G
Asuntha
Rahul
R
Nair
K V Ramana
KV
Murthy
Jayasri
J
Vulava
D031212:Bixaceae; D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry*; D004337:Drug Carriers; D007700:Kinetics; D007783:Lactones / Q000737:chemistry*; D053149:Plant Gums / Q000737:chemistry*; D033362:Powder Diffraction; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013450:Sulfones / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D014867:Water / Q000737:chemistry*
D052246:Cyclooxygenase 2 Inhibitors; D004337:Drug Carriers; D007783:Lactones; D053149:Plant Gums; D012997:Solvents; D013450:Sulfones; D014867:Water; C116926:rofecoxib