Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase.
Arachidonic acid (ARA) metabolites maintain pregnancy and control parturition. We generated a network of 77 proteins involved in placental ARA metabolism to identify novel proteins in this pathway. We identified a long pathway within this network which showed that secretory and cytosolic phospholipase A2 proteins act in concert. The functions of all network proteins expressed in the placental decidua were determined by database searches. Thus ARA metabolism was linked to carbohydrate metabolism. One protein, transmembrane protein 62 (TMEM62), expressed in decidua was previously uncharacterized, and was identified as a putative lipoxygenase. TMEM62 may play a role in pregnancy and/or parturition.
Diabetes and Nutritional Sciences Division, School of Medicine, Franklin Wilkins Building, Stamford Street, London SE1 9NH, UK.
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Jadoon
Department of Biochemistry, School of Biomedical and Health Sciences, King's College London, Franklin Wilkins Building, Stamford Street, London SE1 9NH, UK.
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Cunningham
Diabetes and Nutritional Sciences Division, School of Medicine, Franklin Wilkins Building, Stamford Street, London SE1 9NH, UK. Electronic address: lindsay.mcdermott@kcl.ac.uk.
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McDermott
D000595:Amino Acid Sequence; D016718:Arachidonic Acid / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology; D003656:Decidua / Q000201:enzymology; D005260:Female; D006801:Humans; D008084:Lipoxygenase / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism*; D058945:Lipoxygenases / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism*; D055442:Metabolome; D008958:Models, Molecular; D054467:Phospholipases A2 / Q000378:metabolism; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D016415:Sequence Alignment
D016718:Arachidonic Acid; D058945:Lipoxygenases; C000594253:TMEM62 protein, human; D008084:Lipoxygenase; D054467:Phospholipases A2
Arachidonic acid; Leukotrienes; Lipoxygenase; Metabolism; Protein–protein interactions