TRP Channels Involved in Spontaneous L-Glutamate Release Enhancement in the Adult Rat Spinal Substantia Gelatinosa.
The spinal substantia gelatinosa (SG) plays a pivotal role in modulating nociceptive transmission through dorsal root ganglion (DRG) neurons from the periphery. TRP channels such as TRPV1 and TRPA1 channels expressed in the SG are involved in the regulation of the nociceptive transmission. On the other hand, the TRP channels located in the peripheral terminals of the DRG neurons are activated by nociceptive stimuli given to the periphery and also by plant-derived chemicals, which generates a membrane depolarization. The chemicals also activate the TRP channels in the SG. In this review, we introduce how synaptic transmissions in the SG neurons are affected by various plant-derived chemicals and suggest that the peripheral and central TRP channels may differ in property from each other.
Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan. kumamote@cc.saga-u.ac.jp.
Eiichi
E
Kumamoto
Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan. fujitat@cc.saga-u.ac.jp.
Tsugumi
T
Fujita
Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan. jiang-changyu@hotmail.com.
Chang-Yu
CY
Jiang