Dual-pore mesoporous carbon@silica composite core-shell nanospheres for multidrug delivery.
Monodispersed mesoporous phenolic polymer nanospheres with uniform diameters were prepared and used as the core for the further growth of core-shell mesoporous nanorattles. The hierarchical mesoporous nanospheres have a uniform diameter of 200 nm and dual-ordered mesopores of 3.1 and 5.8 nm. The hierarchical mesostructure and amphiphilicity of the hydrophobic carbon cores and hydrophilic silica shells lead to distinct benefits in multidrug combination therapy with cisplatin and paclitaxel for the treatment of human ovarian cancer, even drug-resistant strains.
Department of Chemistry and Shanghai Key Lab of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers and Advanced Materials Laboratory, Fudan University, Shanghai 200433 (P.R. China).
Yin
Y
Fang
Gengfeng
G
Zheng
Jianping
J
Yang
Haosha
H
Tang
Yafeng
Y
Zhang
Biao
B
Kong
Yingying
Y
Lv
Congjian
C
Xu
Abdullah M
AM
Asiri
Jian
J
Zi
Fan
F
Zhang
Dongyuan
D
Zhao
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity; D002244:Carbon / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D006801:Humans; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology; D017239:Paclitaxel / Q000737:chemistry / Q000633:toxicity; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
D000970:Antineoplastic Agents; D004337:Drug Carriers; D002244:Carbon; D012822:Silicon Dioxide; D017239:Paclitaxel; D002945:Cisplatin
core-shell structures; drug delivery; mesoporous materials; nanoparticles; photonic crystals