Palladium-catalyzed hydroxylation of aryl and heteroaryl halides enabled by the use of a palladacycle precatalyst.
A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.
Department of Chemistry, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Chi Wai
CW
Cheung
Stephen L
SL
Buchwald
D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006900:Hydroxylation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*
D006219:Halogens; D006571:Heterocyclic Compounds; D010636:Phenols; D010165:Palladium