3,5-Dimethoxy-(4-methoxyphenyl)benzamide suppresses adipogenesis in 3T3-L1 cells.
In this study, the adipogenesis-suppressing effect of 3,5-dimethoxy(4-methoxyphenyl)benzamide (DMPB), a derivative of the anti-obesity substance resveratrol, was measured in 3T3-L1 cells. The results show that DMPB effectively suppressed the hormone-induced differentiation of 3T3-L1 cells, compared to resveratrol at the same concentration, and reduced the protein expression of fatty acid synthase and acetyl-CoA carboxylase. In addition, DMPB was observed to decrease the PPAR-gamma transcription activity, which was increased by rosiglitazone, in a concentration-dependent manner. From the above results, it is considered that DMPB shows strong potential as an anti-obesity substance.
Jin Taek
JT
Hwang
Sanghee
S
Kim
Inwook
I
Choi
Sang Yoon
SY
Choi
D041721:3T3-L1 Cells; D050156:Adipogenesis / Q000187:drug effects*; D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors; D051379:Mice; D047495:PPAR gamma / Q000037:antagonists & inhibitors; D011494:Protein Kinases / Q000502:physiology
C514739:2,6-dimethoxy-N-(4-methoxyphenyl)benzamide; D000840:Anisoles; D001549:Benzamides; D047495:PPAR gamma; D064429:Fatty Acid Synthases; D011494:Protein Kinases; C033288:(acetyl-CoA carboxylase) kinase