MGMT promoter methylation status in clival chordoma.
Chordomas are rare, slow-growing neoplasms, characterized by locally aggressive growth patterns and high local recurrence rates. To the best of our knowledge, the MGMT promoter methylation status has not been studied in a population of patients with chordomas to determine if a biologic rationale exists to support the use of temozolomide. We here show for the first time that methylation of MGMT promoter is present in a significant portion or recurring clival chordomas; on the contrary in clival chordomas without recurrence MGMT promoter was always unmethylated (p = 0.0317). Although these observations need to be confirmed in a larger study population, our results (1) indicate that methylation of MGMT promoter is present in a significant portion of recurring chordomas, and (2) prompt further investigation into the potential role of temozolomide as an adjuvant treatment of these tumors.
Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Section of Pathology "M. Malpighi", Bellaria Hospital, Via Altura 3, 40139, Bologna, Italy. gianluca.marucci@ausl.bologna.it.
Gianluca
G
Marucci
Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Section of Pathology "M. Malpighi", Bellaria Hospital, Via Altura 3, 40139, Bologna, Italy.
Luca
L
Morandi
Center of Surgery of Pituitary Tumors and Endoscopic Skullbase, IRCCS Istituto delle scienze neurologiche, Bologna, Italy.
Diego
D
Mazzatenta
Center of Surgery of Pituitary Tumors and Endoscopic Skullbase, IRCCS Istituto delle scienze neurologiche, Bologna, Italy.
Giorgio
G
Frank
Center of Surgery of Pituitary Tumors and Endoscopic Skullbase, IRCCS Istituto delle scienze neurologiche, Bologna, Italy.
Ernesto
E
Pasquini
Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Section of Pathology "M. Malpighi", Bellaria Hospital, Via Altura 3, 40139, Bologna, Italy.
Maria Pia
MP
Foschini
D000328:Adult; D000368:Aged; D002817:Chordoma / Q000235:genetics* / Q000378:metabolism / Q000601:surgery; D003388:Cranial Fossa, Posterior / Q000378:metabolism / Q000601:surgery; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000235:genetics* / Q000378:metabolism; D004252:DNA Mutational Analysis; D045643:DNA Repair Enzymes / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011401:Promoter Regions, Genetic; D019292:Skull Base Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000601:surgery; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
D025521:Tumor Suppressor Proteins; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes