Synthesis of isoquinolines via visible light-promoted insertion of vinyl isocyanides with diaryliodonium salts.
A synthetic strategy for multi-substituted isoquinoline derivatives has been developed using visible light-promoted vinyl isocyanide insertion with diaryliodonium salts at room temperature. The methodology presented here represents the first example of isoquinoline synthesis via somophilic isocyanide insertion.
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. yushouyun@nju.edu.cn njuzy@nju.edu.cn.
Heng
H
Jiang
Yuanzheng
Y
Cheng
Ruzhi
R
Wang
Yan
Y
Zhang
Shouyun
S
Yu
D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D008027:Light; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D009861:Onium Compounds / Q000737:chemistry*; D010666:Phenylpropionates / Q000737:chemistry*; D012492:Salts / Q000737:chemistry
D007546:Isoquinolines; D009570:Nitriles; D009861:Onium Compounds; D010666:Phenylpropionates; D012492:Salts