Task-modulated coactivation of vergence neural substrates.
While functional magnetic resonance imaging (fMRI) has identified which regions of interests (ROIs) are functionally active during a vergence movement (inward or outward eye rotation), task-modulated coactivation between ROIs is less understood. This study tested the following hypotheses: (1) significant task-modulated coactivation would be observed between the frontal eye fields (FEFs), the posterior parietal cortex (PPC), and the cerebellar vermis (CV); (2) significantly more functional activity and task-modulated coactivation would be observed in binocularly normal controls (BNCs) compared with convergence insufficiency (CI) subjects; and (3) after vergence training, the functional activity and task-modulated coactivation would increase in CIs compared with their baseline measurements. A block design of sustained fixation versus vergence eye movements stimulated activity in the FEFs, PPC, and CV. fMRI data from four CI subjects before and after vergence training were compared with seven BNCs. Functional activity was assessed using the blood oxygenation level dependent (BOLD) percent signal change. Task-modulated coactivation was assessed using an ROI-based task-modulated coactivation analysis that revealed significant correlation between the FEF, PPC, and CV ROIs. Prior to vergence training, the CIs had a reduced BOLD percent signal change compared with BNCs for the CV (p<0.05), FEFs, and PPC (p<0.01). The BOLD percent signal change increased within the CV, FEF, and PPC ROIs (p<0.001) as did the task-modulated coactivation between the FEFs and CV as well as the PPC and CV (p<0.05) when comparing the CI pre- and post-training datasets. Results from the Convergence Insufficiency Symptom Survey were correlated to the percent BOLD signal change from the FEFs and CV (p<0.05).
Department of Biomedical Engineering, New Jersey Institute of Technology , Newark, New Jersey.
Rajbir
R
Jaswal
Suril
S
Gohel
Bharat B
BB
Biswal
Tara L
TL
Alvarez
D000293:Adolescent; D000328:Adult; D065814:Cerebellar Vermis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000503:physiopathology; D015835:Ocular Motility Disorders / Q000503:physiopathology* / Q000534:rehabilitation; D010296:Parietal Lobe / Q000503:physiopathology*; D012438:Saccades / Q000502:physiology*; D016896:Treatment Outcome; D055815:Young Adult
Convergence Insufficiency Symptom Survey; cerebellar vermis; convergence insufficiency; frontal eye fields; posterior parietal cortex; task-modulated coactivation; vergence