Immunohistochemical analysis of cyclooxygenase-2 and brain fatty acid binding protein expression in grades I-II meningiomas: correlation with tumor grade and clinical outcome after radiotherapy.
This study was done to evaluate the association of cyclooxygenase 2 (COX-2) and brain fatty acid binding protein (BFABP) with tumor grade and outcome of grades I-II meningiomas treated with radiotherapy. From 1996 to 2008, 40 patients with intracranial grades I-II meningiomas were treated with radiotherapy. Immunohistochemical staining for COX-2 and BFABP were performed on formalin-fixed paraffin-embedded tissues. COX-2 expression was significantly associated with BFABP status and both COX-2 (P < 0.01) and BFABP (P = 0.01) expression were stronger in the grade II meningiomas than in grade I tumors. Among the clinicopathologic factors, age and COX-2 status were prognostic in progression-free survival. Patients with moderate or strong COX-2 expression had worse outcome than those with negative or weak COX-2 expression (P = 0.03) after controlling for potential confounders. Our results suggest that the molecular biomarker COX-2 has prognostic significance in intracranial grades I-II meningiomas following radiotherapy.
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea; Department of Radiation Oncology, Dongnam Institute of Radiological and Medical Sciences, Busan, Korea.
Hyun-Cheol
HC
Kang
Il Han
IH
Kim
Charn Il
CI
Park
Sung-Hye
SH
Park
D000328:Adult; D015415:Biomarkers; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D018450:Disease Progression; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000201:enzymology / Q000532:radiotherapy; D008579:Meningioma / Q000175:diagnosis* / Q000201:enzymology / Q000532:radiotherapy; D008875:Middle Aged; D016019:Survival Analysis; D016896:Treatment Outcome
D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins; D051546:Cyclooxygenase 2
brain fatty acid binding protein; cyclooxygenase-2; immunohistochemistry; meningioma; radiotherapy