HBV influence on Response to Antiretroviral Therapy in Horizontally HIV-HBV Coinfected Patient during Early Childhood.
BACKGROUND
There are few studies on pediatric HIV-HBV coinfection, so evidences about relationships between the two viruses are scarce.


OBJECTIVE
influence of HBV infection on virological and immunological response to antiretroviral therapy (ART) in antiretroviral-naïve horizontally HIV-HBV coinfected subjects during early childhood.


METHODS
observational study on 826 HIV+ subjects in evidence of Craiova Regional Centre (CRC); we analyzed the immunological and virological response at 6-12 months after starting first antiretroviral regimens compared in 2 groups: horizontally HIV-HBV coinfected subjects during early childhood (CoS) versus horizontally HIV infected subjects during early childhood without HBV infection (non-CoS).


RESULTS
Number of subjects: CoS-66 subjects, non-CoS-132 subjects. Demographic data: CoS-gender ratio F:M=0.886, the majority lived in rural area (57.58%), mean age on diagnosis-9.288±4.607 years, non-CoS-gender ratio F:M=0.859, the majority lived in urban area (53.79%), mean age on diagnosis-10.742±5.107 years. At baseline, HIV category was: CoS-A-1.52%, B-80.30%, C-18.18%, non-CoS-A-2.27%, B-70.45%, C-27.27% (p Chi(2)=0.332), the mean CD4+ cell count was: CoS-148.33±148.10 cells/ml, non-CoS-163.17±155.39 cells/ml (p Student=0.521) and the mean HIV viral load (HIV VL) was: CoS-5.06±0.80 lgcopies/ml (for 29 subjects), non-CoS-5.04±0.84 lgcopies/ml (for 61 subjects) (p Student=0.978). At the end of the studied period, the mean increase in CD4+ cell count was: CoS-177.068±141.676 cells/ml, non-CoS-176.015±191.751 cells/ml (p Student=0.969) and the mean decrease in HIV VL was: CoS-5.04±0.79 lgcopies/ml, non-COS-4.69±2.04 lgcopies/ml (p Student=0.911).


CONCLUSIONS
The presence of HBV coinfection does not influence immunological or virological response to ART.
University of Medicine and Pharmacy of Craiova, General Medicine Faculty, Department of Infectious Diseases.
Irina
I
Niculescu
University of Medicine and Pharmacy of Craiova, General Medicine Faculty, Department of Infectious Diseases.
A M
AM
Cupşa
University of Medicine and Pharmacy of Craiova, General Medicine Faculty, Department of Infectious Diseases.
Andreea Cristina
AC
Stoian
University of Medicine and Pharmacy of Craiova, General Medicine Faculty, Department of Infectious Diseases.
Florentina
F
Dumitrescu
University of Medicine and Pharmacy of Craiova, General Medicine Faculty, Department of Infectious Diseases.
L I
LI
Giubelan
University of Medicine and Pharmacy of Craiova, General Medicine Faculty, Department of Informatics.
D O
DO
Alexandru
ART; CoS; immunological response; non-CoS; virological response