Carbon dioxide levels during polygraphy in children with sleep-disordered breathing.
OBJECTIVE
The recent scoring rules of the American Academy of Sleep Medicine (AASM) define hypoventilation in children as a carbon dioxide (CO2) level of >50 mmHg for >25 % of total sleep time (partial pressure of CO2 (PCO2) > 50[>25 %]). As there is no validated level of nocturnal hypoventilation with regard to end-organ damage in children, we evaluated the prevalence of hypoventilation with the AASM definition but also with a lesser degree of elevated CO2 in children with sleep-disordered breathing (SDB).


METHODS
Transcutaneous CO2 (PtcCO2) was recorded during overnight polygraphy (PG). Hypoventilation was defined according to four definitions: the AASM score (PCO2 > 50[>25 %]), the peak value of PtcCO2 > 50 mmHg (PtcCO2 > 50[peak]), a percentage of PtcCO2 > 50 mmHg > 2 % of nighttime recording (PtcCO2 > 50[>2 %]) or a nocturnal PtcCO2 > 10 mmHg above waking baseline level (PtcCO2[>10 mmHg]). PtcCO2 indices were correlated to the apnoea-hypopnoea index (AHI) and oxygenation indices.


RESULTS
PGs from 221 children with suspicion of obstructive sleep apnoea (72 %), neuromuscular diseases (21 %), and lung diseases (7 %) were analysed. The prevalence of hypoventilation according to PCO2 > 50[>25 %], PtcCO2 > 50[peak], PtcCO2 > 50[>2 %] and PtcCO2[>10 mmHg] were 16, 27, 31 and 52 %, respectively, and did not differ between the three diagnostic groups. Significant but weak correlations were observed between hypoventilation and AHI and oxygenation indices.


CONCLUSIONS
Nocturnal hypoventilation occurs in a large number of children referred for SDB, independent of the underlying disease, when more stringent criteria than those of the AASM are used. The poor correlation between hypoventilation and AHI or oxygenation indices is in favour of CO2 being a supplemental index of SDB.
Paediatric Pulmonary Department, AP-HP, Hôpital Armand Trousseau, 75012, Paris, France, jadepautrat@hotmail.com.
Jade
J
Pautrat
Sonia
S
Khirani
Michèle
M
Boulé
Adriana
A
Ramirez
Nicole
N
Beydon
Brigitte
B
Fauroux
D002245:Carbon Dioxide / Q000097:blood*; D003937:Diagnosis, Differential; D006801:Humans; D007040:Hypoventilation / Q000097:blood / Q000175:diagnosis; D008171:Lung Diseases / Q000097:blood / Q000175:diagnosis; D009468:Neuromuscular Diseases / Q000097:blood / Q000175:diagnosis; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000175:diagnosis*
D002245:Carbon Dioxide