Magnetic fluid hyperthermia inhibits the growth of breast carcinoma and downregulates vascular endothelial growth factor expression.
The application of magnetic fluid hyperthermia (MFH) with nanoparticles has been shown to inhibit tumor growth in several animal models. However, the feasibility of using MFHin vivoto treat breast cancer is uncertain, and the mechanism is unclear. In the present study, it was observed that the intratumoral administration of MFH induced hyperthermia significantly in rats with Walker-265 breast carcinomas. The hyperthermia treatment with magnetic nanoparticles inhibited tumor growthin vivoand promoted the survival of the tumor-bearing rats. Furthermore, it was found that MFH treatment downregulated the protein expression of vascular endothelial growth factor (VEGF) in the tumor tissue, as observed by immunohistochemistry. MFH treatment also decreased the gene expression of VEGF and its receptors, VEGF receptor 1 and 2, and inhibited angiogenesis in the tumor tissues. Taken together, these results indicate that the application of MFH with nanoparticles is feasible for the treatment of breast carcinoma. The MFH-induced downregulation of angiogenesis may also contribute to the induction of an anti-tumor effect.
Cancer Center/Cancer Research Institute, Changsha Central Hospital, Changsha, Hunan 410004, P.R. China ; Cancer Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Guihua
G
Wang
Cancer Center/Cancer Research Institute, Changsha Central Hospital, Changsha, Hunan 410004, P.R. China.
Derong
D
Xu
Cancer Center/Cancer Research Institute, Changsha Central Hospital, Changsha, Hunan 410004, P.R. China.
Qin
Q
Chai
Cancer Center/Cancer Research Institute, Changsha Central Hospital, Changsha, Hunan 410004, P.R. China.
Xiaolang
X
Tan
Laboratory for Jiangsu Biomaterials and Devices, State Key Laboratory of Bioelectronics, Southeast University, Nanjing, Jiangsu 210096, P.R. China.
Yu
Y
Zhang
Laboratory for Jiangsu Biomaterials and Devices, State Key Laboratory of Bioelectronics, Southeast University, Nanjing, Jiangsu 210096, P.R. China.
Ning
N
Gu
Medical Physics and Engineering Institute, Department of Engineering Physics, Tsinghua University, Beijing 100084, P.R. China.
Jintian
J
Tang
angiogenesis; breast carcinoma; magnetic nanoparticle; thermotherapy; vascular endothelial growth factor