Genetic association between the dopamine D1-receptor gene and paranoid schizophrenia in a northern Han Chinese population.
OBJECTIVE
Dysregulation of dopaminergic neurotransmission at the D1 receptor in the prefrontal cortex has been implicated in the pathogenesis of schizophrenia. Genetic polymorphisms of the dopamine D1-receptor gene have a plausible role in modulating the risk of schizophrenia. To determine the role of DRD1 genetic polymorphisms as a risk factor for schizophrenia, we undertook a case-control study to look for an association between the DRD1 gene and schizophrenia.


METHODS
We genotyped eleven single-nucleotide polymorphisms within the DRD1 gene by deoxyribonucleic acid sequencing involving 173 paranoid schizophrenia patients and 213 unrelated healthy individuals. Statistical analysis was performed to identify the difference of genotype, allele, or haplotype distribution between cases and controls.


RESULTS
A significantly lower risk of paranoid schizophrenia was associated with the AG + GG genotype of rs5326 and the AG + GG genotype of rs4532 compared to the AA genotype and the AA genotype, respectively. Distribution of haplotypes was no different between controls and paranoid schizophrenia patients. In the males, the genotype distribution of rs5326 was statistically different between cases and controls. In the females, the genotype distribution of rs4532 was statistically different between cases and controls. However, the aforementioned statistical significances were lost after Bonferroni correction.


CONCLUSIONS
It is unlikely that DRD1 accounts for a substantial proportion of the genetic risk for schizophrenia. As an important dopaminergic gene, DRD1 may contribute to schizophrenia by interacting with other genes, and further relevant studies are warranted.
Institute of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
Jun
J
Yao
Institute of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
Mei
M
Ding
Institute of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
Jiaxin
J
Xing
Institute of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
Jinfeng
J
Xuan
Institute of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
Hao
H
Pang
Institute of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
Yuqing
Y
Pan
Institute of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
Baojie
B
Wang
association; dopamine D1 receptor; genetic polymorphism; paranoid schizophrenic; single-nucleotide study