Triactome: neuro-immune-adipose interactions. Implication in vascular biology.
Understanding how the precise interactions of nerves, immune cells, and adipose tissue account for cardiovascular and metabolic biology is a central aim of biomedical research at present. A long standing paradigm holds that the vascular wall is composed of three concentric tissue coats (tunicae): intima, media, and adventitia. However, large- and medium-sized arteries, where usually atherosclerotic lesions develop, are consistently surrounded by periadventitial adipose tissue (PAAT), we recently designated tunica adiposa (in brief, adiposa like intima, media, and adventitia). Today, atherosclerosis is considered an immune-mediated inflammatory disease featured by endothelial dysfunction/intimal thickening, medial atrophy, and adventitial lesions associated with adipose dysfunction, whereas hypertension is characterized by hyperinnervation-associated medial thickening due to smooth muscle cell hypertrophy/hyperplasia. PAAT expansion is associated with increased infiltration of immune cells, both adipocytes and immunocytes secreting pro-inflammatory and anti-inflammatory (metabotrophic) signaling proteins collectively dubbed adipokines. However, the role of vascular nerves and their interactions with immune cells and paracrine adipose tissue is not yet evaluated in such an integrated way. The present review attempts to briefly highlight the findings in basic and translational sciences in this area focusing on neuro-immune-adipose interactions, herein referred to as triactome. Triactome-targeted pharmacology may provide a novel therapeutic approach in cardiovascular disease.
Laboratory of Cell Biology, Department of Anatomy and Histology, Medical University , Varna , Bulgaria.
George Nikov
GN
Chaldakov
Institute of Cellular Biology and Neurobiology, National Research Council , Rome , Italy.
Marco
M
Fiore
Department of General and Clinical Pathology, Medical University , Varna , Bulgaria.
Peter I
PI
Ghenev
Department of Pathophysiology, Medical University , Lublin , Poland.
Jerzy
J
Beltowski
Department of Histology and Embryology, University Medical Faculty , Niš , Serbia.
Gorana
G
Ranćić
Department of Physiology, Medical Faculty, Eskişehir University , Eskişehir , Turkey.
Neşe
N
Tunçel
Institute of Cellular Biology and Neurobiology, National Research Council , Rome , Italy.
Luigi
L
Aloe
BDNF; NGF; adipokines; adipose tissue; atherosclerosis; lymphocytes; mast cells; perivascular nerves