Mean platelet volume in nasal polyps.
BACKGROUND
Many studies in literature point out that inflammation related to nasal polyp is mostly dependent on eosinophils and their inflammatory products. Beside eosinophils, platelets may have a role in nasal polyp development. Platelets are involved in haemostasis, tissue repairing and inflammation. However, to our knowledge, there are no reports in the literature that study the association between platelet parameters and nasal polyps.


METHODS
Forty-three patients with nasal polyps and forty-nine healthy controls were enrolled in the study, retrospectively. Laboratory data of patients with nasal polyp were obtained at the time of diagnosis.


RESULTS
There were no statistically significant differences between the two groups in terms of white blood count, haemoglobin, haematocrit and platelet count. The mean platelet volume (MPV) value of the nasal polyp group was significantly lower than the control group (p = 0.025). Mean eosinophil count was significantly elevated in the nasal polyp group compared to the control group (p < 0.001).


CONCLUSIONS
Reduction in MPV may be an indicator for nasal polyp formation. Further studies with a larger study population are needed to detect the possible correlation between eosinophil count and MPV values in patients with nasal polyps.
Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey. draliaktas@yahoo.com.
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Aktas
Department of General Surgery, Abant Izzet Baysal University Hospital, Bolu, Turkey.
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Sit
Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
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Tekce
Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
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Alcelik
Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
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Savli
Department of Otolaryngology, Abant Izzet Baysal University Hospital, Bolu, Turkey.
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Simsek
Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
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Ozmen
Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
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Isci
Department of Otolaryngology, Abant Izzet Baysal University Hospital, Bolu, Turkey.
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Apuhan
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D009298:Nasal Polyps / Q000503:physiopathology*; D012189:Retrospective Studies