Outcomes of orthotopic liver transplantation in non-malignant end-stage liver diseases.
BACKGROUND
Orthotopic liver transplantation (OLT) is an effective treatment for patients who have end-stage liver disease. The aim of this study is to compare outcomes of OLT in fulminant hepatic failure (FHF) and non-fulminant hepatic failure (non-FHF) patients.


METHODS
A retrospective review of adult patients who underwent OLT for non-malignant end-stage liver diseases between 2002 and 2011 at Siriraj Hospital was performed. All explanted liver histopathology results were reviewed. The clinical factors and overall results of OLT were analyzed.


RESULTS
Of the 137 patients, 72 patients had non-malignant diagnoses. Eleven patients were diagnosed with FHF, whereas 61 patients were in the non-FHF group. The most common indication for liver transplantation was chronic viral hepatitis. One- and 5-year survival rates (95% confidence interval) in the FHF group were 91% (51%-99%) and 91% (51%-99%), respectively, whereas those in the non-FHF group were 74% (61%-83%) and 66% (52%-77%), respectively. Multivariate cox regression analysis revealed no statistically significant difference of survival between both groups (P = .34).


CONCLUSIONS
The post-OLT outcomes in non-malignant patients were comparable between FHF and non-FHF groups in terms of survival. OLT remains the only therapeutic option for the FHF patients.
HepatoPancreatoBiliary and Transplant Surgery Unit, Division of General Surgery, Department of Surgery, Siriraj Organ Transplantation Center, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand. Electronic address: yongyut.sir@mahidol.ac.th.
Y
Y
Sirivatanauksorn
HepatoPancreatoBiliary and Transplant Surgery Unit, Division of General Surgery, Department of Surgery, Siriraj Organ Transplantation Center, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
N
N
Kongkaewpaisan
Department of Pathology, Siriraj Organ Transplantation Center, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
A
A
Pongpaibul
HepatoPancreatoBiliary and Transplant Surgery Unit, Division of General Surgery, Department of Surgery, Siriraj Organ Transplantation Center, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
S
S
Limsrichamrern
HepatoPancreatoBiliary and Transplant Surgery Unit, Division of General Surgery, Department of Surgery, Siriraj Organ Transplantation Center, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
P
P
Mahawithitwong
HepatoPancreatoBiliary and Transplant Surgery Unit, Division of General Surgery, Department of Surgery, Siriraj Organ Transplantation Center, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
P
P
Kositamongkol
HepatoPancreatoBiliary and Transplant Surgery Unit, Division of General Surgery, Department of Surgery, Siriraj Organ Transplantation Center, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
C
C
Tovikkai
HepatoPancreatoBiliary and Transplant Surgery Unit, Division of General Surgery, Department of Surgery, Siriraj Organ Transplantation Center, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
S
S
Asavakarn
D000328:Adult; D058625:End Stage Liver Disease / Q000601:surgery*; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome