Prospective population-based study of the association between serum 25-hydroxyvitamin-D levels and the incidence of specific types of cancer.
BACKGROUND
Observational studies have suggested an inverse association between vitamin D status and cancer. We investigated the prospective associations between vitamin D status and the total and specific type of cancer in three cohorts from the general Danish population.


METHODS
A total of 12,204 individuals 18 to 71 years old were included. The level of 25-hydroxyvitamin D was measured at baseline, and information about cancer was obtained from the Danish Cancer Registry.


RESULTS
During the 11.3-year median follow-up time, there were 1,248 incident cancers. HRs [95% confidence intervals (CI)] per 10 nmol/L higher baseline vitamin D level were: for all cancers (HR = 1.02; 95% CI, 0.99-1.04), all cancers excluding non-melanoma skin cancer, NMSC (HR = 1.00; 95% CI, 0.97-1.03), head and neck cancer (HR = 0.97; 95% CI, 0.84-1.12), colorectal cancer (HR = 0.95; 95% CI, 0.88-1.02), cancer of bronchus and lung (HR = 0.98; 95% CI, 0.91-1.05), breast cancer (HR = 1.02; 95% CI, 0.96-1.09), cancer of the uterus (HR = 1.10; 95% CI, 0.95-1.27), prostate cancer (HR = 1.00; 95% CI, 0.93-1.08), cancer of the urinary organs (HR = 1.01; 95% CI, 0.90-1.14), NMSC (HR = 1.06; 95% CI, 1.02-1.10), and malignant melanoma (HR = 1.06; 95% CI, 0.95-1.17).


CONCLUSIONS
Apart from a significantly higher risk for NMSC with higher vitamin D status, we found no statistically significant associations between vitamin D status and total or specific cancers.


CONCLUSIONS
Our results do not indicate that there is an impact of vitamin D on total cancer incidence.
Authors' Affiliations: Research Centre for Prevention and Health and tea.skaaby.01@regionh.dk.
Tea
T
Skaaby
Authors' Affiliations: Research Centre for Prevention and Health and.
Lise Lotte Nystrup
LL
Husemoen
Authors' Affiliations: Research Centre for Prevention and Health and.
Betina Heinsbæk
BH
Thuesen
Authors' Affiliations: Research Centre for Prevention and Health and.
Charlotta
C
Pisinger
Authors' Affiliations: Research Centre for Prevention and Health and Faculty of Health Science and Faculty of Medicine, Alborg University, Alborg;
Torben
T
Jørgensen
Danish Cancer Society Research Centre, Copenhagen; and.
Nina
N
Roswall
Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, Frederiksberg, Denmark.
Sofus Christian
SC
Larsen
Authors' Affiliations: Research Centre for Prevention and Health and Department of Clinical Experimental Research, Glostrup University Hospital, Glostrup; Department of Clinical Medicine, University of Copenhagen, Copenhagen;
Allan
A
Linneberg
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000453:epidemiology*; D011446:Prospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
D014807:Vitamin D; C104450:25-hydroxyvitamin D