[Role of CD8(+)T cells and their secreted cytokines in the pathogenesis of aplastic anemia].
Aplastic anemia(AA) is mostly considered as an immune-mediated bone marrow failure syndrome, characterized by pancytopenia and bone marrow hypoplasia. The pathogenesis of AA is complicated, until now it is not fully understood. Further study on the pathological mechanism will be helpful for the diagnosis and treatment of AA. CD8(+) T cells and their secreted cytokines play important roles in the abnormal immunity during the process of AA. Thus, this review focuses on the role of CD8(+) T cells and their secreted cytokines in the pathogenesis of AA.
Medical College of Qinghai University, Qinghai Provincial People's Hospital, Xining 810007, Qinghai Province, China.
Bai-Li
BL
Jiang
Department of Hematology, Qinghai Provincial People's Hospital, Xining 810007, Qinghai Province, China.
Jian-Ping
JP
Li
Department of Hematology, Qinghai Provincial People's Hospital, Xining 810007, Qinghai Province, China.
Wen-Qian
WQ
Li
Department of Hematology, Qinghai Provincial People's Hospital, Xining 810007, Qinghai Province, China. E-mail: fjmok@sohu.com.
Jian-Ming
JM
Feng
D000741:Anemia, Aplastic / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular
D016207:Cytokines