Identical lesion morphology in primary progressive and relapsing-remitting MS--an ultrahigh field MRI study.
Potential differences between primary progressive (PP) and relapsing-remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology and distribution in patients with PPMS and RRMS (nine in each group) using 7 T MRI. We found that gray and white matter lesions in PPMS and RRMS patients did not differ in their respective morphological characteristics (e.g., perivascular p = 0.863, hypointense rim p = 0.796, cortical lesion count p = 0.436). Although limited by a small sample size, our study results suggest that PPMS and RRMS, despite differences in disease course and clinical characteristics, exhibit identical lesion morphology under ultrahigh field MRI.
NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Germany.
Joseph
J
Kuchling
NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Germany.
Caren
C
Ramien
NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Germany.
Ivan
I
Bozin
NeuroCure Clinical Research Center/Clinical and Experimental MS Research Center, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
Jan
J
Dörr
Clinical and Experimental MS Research Center/Charité - Universitaetsmedizin Berlin, Berlin, Germany.
Lutz
L
Harms
Clinical and Experimental MS Research Center/Charité - Universitaetsmedizin Berlin, Berlin, Germany.
Berit
B
Rosche
Berlin Ultrahigh Field Facility (BUFF)/Experimental and Clinical Research Center, Charité - Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Thoralf
T
Niendorf
NeuroCure Clinical Research Center/Clinical and Experimental MS Research Center/Experimental and Clinical Research Center, Charité - Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany friedemann.paul@charite.de.
Friedemann
F
Paul
NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Germany/Asklepios Fachklinikum Teupitz, Germany.
Tim
T
Sinnecker
NeuroCure Clinical Research Center/BUFF, Max Delbrueck Center for Molecular Medicine, Berlin, Germany/Experimental and Clinical Research Center, Charité - Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin/Institute of Neuroradiology, University Medicine Goettingen, Germany.
Jens
J
Wuerfel
D000328:Adult; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000473:pathology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000473:pathology*; D066127:White Matter / Q000473:pathology*
7 T MRI; MRI; PPMS; RRMS; primary progressive multiple sclerosis; relapsing–remitting multiple sclerosis; ultrahigh field MRI