[Research advances on the roles of nicotinamide phosphoribosyltransferase in inflammation].
Nicotinamide phosphoribosyltransferase (Nampt) is also called visfatin or pre-B-cell colony-enhancing factor. The functions of Nampt have been reported as a cytokine, an adipokine and the rate-limiting enzyme in nicotinamide adenine dinucleotide biosynthesis. As a pleiotropic multifunctional protein, Nampt is involved in a variety of physiological and pathological conditions including innate immunity, metabolic disorders, and stress; and Nampt also participates in inflammatory disorders such as acute lung injury, atherosclerosis, myocardial infarct, obesity, type 2 diabetes, and rheumatoid arthritis. The studies indicate that Nampt might be a potential target for pharmacological intervention against inflammatory diseases. We review research advances on the roles of Nampt in inflammation.
Department of Pharmacology, Zhejiang University School of Medicine; Key Laboratory of Medical Neurobiology of Ministry of Health, Hangzhou 310058, China.
Jing
J
Huang
Department of Pharmacology, Zhejiang University School of Medicine; Key Laboratory of Medical Neurobiology of Ministry of Health, Hangzhou 310058, China.
Er-qing
EQ
Wei
Department of Pharmacology, Zhejiang University School of Medicine; Key Laboratory of Medical Neurobiology of Ministry of Health, Hangzhou 310058, China.
Yun-bi
YB
Lu
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000201:enzymology*; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism*
D054409:Nicotinamide Phosphoribosyltransferase