High IgE levels in patients affected by psoriasis: review of the literature and personal observations.
OBJECTIVE
The concomitance of psoriasis and high IgE levels in the same patient, possibly associated to allergies, should not come as a surprise anymore, because both diseases are characterised by an immunological disorder, involving cytokines and other inflammatory mediators, with massive activation of the cell-mediated immunity.


METHODS
During a period of 18 months, using a radio-immunologic method, we assessed the level of IgE in patients with severe psoriasis who were not responding to the common therapy.


RESULTS
Patients with severe psoriasis had high levels of IgE.


CONCLUSIONS
IgEs have an important role in pathogenesis of psoriasis and atopic dermatitis, but the mechanism is not yet clear.
Department of Clinical and Molecular Medicine, Faculty of Medicine and Psycology, "Sapienza" University of Rom, Italy.
S B
SB
Paparo
Department of Clinical and Molecular Medicine, Faculty of Medicine and Psycology, "Sapienza" University of Rom, Italy.
M A
MA
Guaragna
Department of Immunology, Institute Pasteur, Paris, France.
M
M
Albanesi
D000328:Adult; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000276:immunology; D012720:Severity of Illness Index
D007073:Immunoglobulin E