Physical exercise training and neurovascular unit in ischemic stroke.
Physical exercise could exert a neuroprotective effect in both clinical studies and animal experiments. A series of related studies have indicated that physical exercise could reduce infarct volume, alleviate neurological deficits, decrease blood-brain barrier dysfunction, promote angiogenesis in cerebral vascular system and increase the survival rate after ischemic stroke. In this review, we summarized the protective effects of physical exercise on neurovascular unit (NVU), including neurons, astrocytes, pericytes and the extracellular matrix. Furthermore, it was demonstrated that exercise training could decrease the blood-brain barrier dysfunction and promote angiogenesis in cerebral vascular system. An awareness of the exercise intervention benefits pre- and post stroke may lead more stroke patients and people with high-risk factors to accept exercise therapy for the prevention and treatment of stroke.
Department of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China.
X
X
Wang
Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, PR China.
M
M
Zhang
Department of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China.
R
R
Feng
Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, PR China.
W B
WB
Li
Department of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China.
S Q
SQ
Ren
Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China.
J
J
Zhang
Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China; Hebei Provincial Orthopedic Biomechanics Key Laboratory, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China. Electronic address: zjk20019@126.com.
F
F
Zhang
D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D020521:Stroke / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*
angiogenesis; blood-brain barrier (BBB); cerebral blood vessels; neurovascular unit (NVU); stroke