Ready, set, go! How protein kinase C manages dynamic signaling.
In this issue of Chemistry & Biology, Antal and colleagues describe how phosphorylation optimizes the signaling range of protein kinase C (PKC) isoforms. Priming of these enzymes regulates intramolecular conformational changes, which reduces access to their diacylglycerol (DAG) binding C1 domains.
Department of Biochemistry & Molecular Biology, Indiana University School of Medicine-South Bend, South Bend, IN 46617, USA; Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. Electronic address: rstaheli@iupui.edu.
Robert V
RV
Stahelin
D000818:Animals; D011493:Protein Kinase C / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction
D011493:Protein Kinase C