[Latest research progress on pathogenesis of chronic graft versus host disease and its related problems].
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective method for the treating of malignant diseases of hematopoietic system or non-malignant proliferative diseases, but the occurrence of graft-versus-host disease (GVHD) limits the success rate of hematopoietic stem cell transplantation. Moreover, chronic graft-versus-host disease (cGVHD) is the main factor affecting the long-term survival rate and life quality of recipient after hematopoietic stem cell transplantation. In this article, the latest research progress of the pathogenesis of cGVHD and related problems are reviewed from the thymus, cytokines, T lymphocyte subsets, B lymphocytes and its secreted antibody.
Base for Training Postgranduates, Shengyang Military Command Gerenal Hospital, Liaoning Medical College, Shengyang 110016, Liaoning Province, China; Department of Cell Biology, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.
Xi-Mei
XM
Li
Department of Cell Biology, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.
Heng
H
Zhu
Base for Training Postgranduates, Shengyang Military Command Gerenal Hospital, Liaoning Medical College, Shengyang 110016, Liaoning Province, China. E-mail: zhoufan611@sina.com.cn.
Fan
F
Zhou
Department of Cell Biology, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China. E-mail: zhangyi612@hotmail.com.
Yi
Y
Zhang
D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000276:immunology / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D014184:Transplantation, Homologous