Risk factors for adult-onset recurrent respiratory papillomatosis.
OBJECTIVE
To evaluate risk factors strongly associated with adult-onset recurrent respiratory papillomatosis (AO-RRP).


METHODS
Prospective, age- and sex-matched, case control.


METHODS
Patients with AO-RRP and controls completed a computer-based, 89-item questionnaire across three academic institutions.


RESULTS
Forty-eight AO-RRP patients were compared to 73 controls; 43 of the 48 AO-RRP patients were male (89.5%). The difference in the median number of lifetime sexual partners between AO-RRP (15) and controls (10) was significant (P = 0.0387). Additionally, an increased number of lifetime sexual partners (≥ 26) was associated with AO-RRP. No significant difference for the number of lifetime oral sex partners was observed between groups. Increased comorbidity, as quantified by the Charlson Comorbidity Index, was observed in patients with AO-RRP. AO-RRP and control groups were similar across many other variables, including birth history, smoking history, alcohol use, drug use, education, income, and the Short Form Health Survey scores.


CONCLUSIONS
AO-RRP was not associated with previously proposed risk factors for juvenile-onset RRP and may be associated with an increased number of lifetime sexual partners.
NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York, New York, U.S.A.
Ryan
R
Ruiz
Stratos
S
Achlatis
Avanti
A
Verma
Hayley
H
Born
Farzana
F
Kapadia
Yixin
Y
Fang
Michael
M
Pitman
Lucian
L
Sulica
Ryan C
RC
Branski
Milan R
MR
Amin
D000328:Adult; D017668:Age of Onset; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000635:transmission; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000635:transmission; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012747:Sexual Partners; D015229:Sexually Transmitted Diseases, Viral / Q000453:epidemiology*; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology; D055815:Young Adult
Recurrent respiratory papillomatosis; human papillomavirus; larynx; voice