Inflammation-associated activation of coagulation and immune regulation by the protein C pathway.
The inflammation-induced activation of the protein C pathway provides negative feedback inhibition of coagulation and exerts coagulation-independent anti-inflammatory and cytoprotective effects. The balance between these activities of aPC modulates the outcome of diverse inflammatory diseases such as encephalitis, diabetes, and sepsis; and is affected by naturally occurring aPC-resistance of coagulation factor V Leiden.
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee WI, USA; Department of Physiology, Medical College of Wisconsin, Milwaukee WI, USA. Electronic address: Hartmut.Weiler@bcw.edu.
Hartmut
H
Weiler
D020016:Activated Protein C Resistance / Q000150:complications / Q000276:immunology; D000818:Animals; D001777:Blood Coagulation; D001927:Brain Diseases / Q000276:immunology; D048909:Diabetes Complications / Q000150:complications / Q000276:immunology; D004660:Encephalitis; D005165:Factor V / Q000276:immunology; D050031:Hashimoto Disease / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000276:immunology; D011486:Protein C / Q000276:immunology*; D018805:Sepsis / Q000150:complications / Q000276:immunology; D015398:Signal Transduction
D011486:Protein C; C095381:factor V Leiden; D005165:Factor V
Factor V Leiden; Inflammation; Protein C