ZnO nanorod-templated well-aligned ZrO2 nanotube arrays for fibroblast adhesion and proliferation.
Cellular responses to porous tubular structures have recently been investigated in highly ordered ZrO2 nanotube arrays fabricated with anodization. However, the potential applications of the nanotube arrays are hindered by instrument requirements and substrate limitations, as well as by the complicated processes needed for synthesis. In this work, ZrO2 nanotube arrays were synthesized by in situ hydrolysis of zirconium propoxide with a zinc oxide nanorod array-based template. Fibroblast cells were able to grow on the nanotube array surface with produced elongated filopodia. Studies of the capability of cell growth and the expression of adhesion- and proliferation-related genes reveal that ZrO2 nanotube arrays may provide a better environment for cell adhesion and growth than a flat titanium surface. These findings not only provide fundamental insight into cell response to nanostructures but also provide an opportunity to use a unique approach to fabricate ZrO2 nanotube array structures for potential implant applications.
Chongqing Key Laboratory for Advanced Materials & Technologies of Clean Energies, Southwest University, Chongqing 400715, People's Republic of China. Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing 400715, People's Republic of China. Faculty of Materials & Energy, Southwest University, Chongqing 400715, People's Republic of China.
Zhisong
Z
Lu
Zhihong
Z
Zhu
Jinping
J
Liu
Weihua
W
Hu
Chang Ming
CM
Li
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D043942:Nanotubes / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry* / Q000494:pharmacology; D015040:Zirconium / Q000737:chemistry* / Q000494:pharmacology
D015040:Zirconium; C028541:zirconium oxide; D015034:Zinc Oxide