Possibility of usage of aminostigmine structural analogue for the treatment of toxic cognitive disorders.
We studied the effects of 2-(hexyl(methyl)amino)methyl)pyridyl-3-dimethyl carbamate (OPDC), a structural analogue of aminostigmine oxalate, on memory formation in rats with toxic scopolamine-induced amnesia. It was shown that OPDC in non-toxic doses ((1)/215 LD50) has significant anti-amnesic action. Ipidacrine and galantamine in the doses similar to toxic doses ((1)/17 and (1)/6 of LD50, respectively) induced the retention of memory trace. Administration of aminostigmine ((1)/11 of LD50) induced unstable anti-amnesic effect in the model of scopolamine-induced amnesia.
Research Experimental Institute of Military Medicine, S. M. Kirov Military Medical Academy, St. Petersburg, Russia, fateev_ivan@mail.ru.
I V
IV
Fateev
S N
SN
Subbotina
A F
AF
Kurpyakova
M A
MA
Tyunin
D000818:Animals; D002219:Carbamates / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000188:drug therapy*; D007928:Lethal Dose 50; D008297:Male; D011729:Pyridostigmine Bromide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats
D002219:Carbamates; C070102:aminostigmine; D011729:Pyridostigmine Bromide