Microcirculation and structural reorganization of the bladder mucosa in chronic cystitis under conditions of ozone therapy.
Structural reorganization of the bladder mucosa in chronic cystitis and its correction by ozone therapy were studied. A relationship between the epithelial layer restructuring of different kinds (dystrophy, metaplasia, and degeneration), level of cell proliferation, and ultrastructural organization of urotheliocytes was detected. This complex of structural reactions was combined with dysregulation of tissue bloodflow in the bladder mucosa, shown by laser Doppler flowmetry. Positive structural changes were most marked in intravesical and less so in parenteral ozone therapy added to the therapeutic complex and manifested in reduction of inflammation and alteration in parallel with more intense reparative reactions. A special feature of parenteral ozone therapy was a significant improvement of microcirculation in the bladder mucosa.
Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia, pathol@soramn.ru.
A I
AI
Neimark
L M
LM
Nepomnyashchikh
E L
EL
Lushnikova
M A
MA
Bakarev
N A
NA
Abdullaev
K A
KA
Sizov
D000328:Adult; D000368:Aged; D003556:Cystitis / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008833:Microcirculation; D008875:Middle Aged; D009092:Mucous Membrane; D010126:Ozone / Q000627:therapeutic use*; D001743:Urinary Bladder / Q000033:anatomy & histology* / Q000098:blood supply*; D055815:Young Adult
D010126:Ozone