Catalase, carbonic anhydrase and xanthine oxidase activities in patients with mycosis fungoides.
Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. In several studies the relationship between catalase (CAT), human cytosolic carbonic anhydrases (CA; hCA-I and hCA-II) and xanthine oxidase (XO) enzyme activities have been investigated in various types of cancers but carbonic anhydrase, catalase and xanthine oxidase activities in patients with MF have not been previously reported. Therefore, in this preliminary study we aim to investigate CAT, CA and XO activities in patients with MF. This study enrolled 32 patients with MF and 26 healthy controls. According to the results, CA and CAT activities were significantly lower in patients with mycosis fungoides than controls (p < 0.001) (p < 0.001). There was no significant difference in XO activity between patient and control group (p = 0.601). Within these findings, we believe these enzyme activity levels might be a potentially important finding as an additional diagnostic biochemical tool for MF.
Kars State Hospital, Dermatology Clinic Kars State Hospital , Kars , Turkey .
Fatma Pelin
FP
Cengiz
Serap
S
Beyaztas
Basak
B
Gokce
Oktay
O
Arslan
Ozen Ozensoy
OO
Guler
D002256:Carbonic Anhydrases / Q000378:metabolism*; D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000097:blood / Q000201:enzymology*; D012878:Skin Neoplasms / Q000097:blood / Q000201:enzymology*; D014969:Xanthine Oxidase / Q000378:metabolism*
D002374:Catalase; D014969:Xanthine Oxidase; D002256:Carbonic Anhydrases
Carbonic anhydrase; catalase; mycosis fungoides; xanthine oxidase