Frequency and abundance of alphaherpesvirus DNA in human thoracic sympathetic ganglia.
Alphaherpesvirus reactivation from thoracic sympathetic ganglia (TSG) and transaxonal spread to target organs cause human visceral disease. Yet alphaherpesvirus latency in TSG has not been well characterized. In this study, quantitative PCR detected varicella-zoster virus (VZV), herpes simplex virus 1 (HSV-1), and HSV-2 DNA in 117 fresh TSG obtained postmortem from 15 subjects. VZV DNA was found in 76 (65%) ganglia from all subjects, HSV-1 DNA was found in 5 (4%) ganglia from 3 subjects, and no HSV-2 was found.
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA maria.nagel@ucdenver.edu.
Maria A
MA
Nagel
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
April
A
Rempel
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Jonathon
J
Huntington
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Forrest
F
Kim
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Alexander
A
Choe
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Don
D
Gilden
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D005728:Ganglia, Sympathetic / Q000821:virology*; D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000302:isolation & purification*; D018258:Herpesvirus 2, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D060888:Real-Time Polymerase Chain Reaction; D013233:Stellate Ganglion / Q000821:virology*; D018140:Varicellovirus / Q000235:genetics / Q000302:isolation & purification*; D017735:Virus Latency
D004279:DNA, Viral