Regeneration of the periodontium for preservation of the damaged tooth.
The population of the world grows every year, and life expectancy tends to increase. Thus, long-term preservation of teeth in aged individuals is an urgent issue. The main causes of tooth loss are well known to be periodontitis, caries, fractures, and orthodontic conditions. Although implant placement is a widely accepted treatment for tooth loss, most patients desire to preserve their own teeth. Many clinicians and researchers are therefore challenged to treat and preserve teeth that are irreversibly affected by deep caries, periodontitis, fractures, and trauma. Tissue engineering techniques are beneficial in addressing this issue; stem cells, signal molecules, and scaffolds are the main elements of such techniques. In this review, we describe these three elements with respect to their validation for regeneration of the periodontium and focus particularly on the potency of diverse scaffolds. In addition, we provide a short overview of the ongoing studies of 4-methacryloxyethyl trimellitate anhydride/methyl methacrylate-tri-n-butyl-borane resin including calcium chloride or hydroxyapatite for periodontium regeneration.
Department of Endodontology, Kyushu University Hospital, Fukuoka, Japan. hide@dent.kyushu-u.ac.jp.
Hidefumi
H
Maeda
Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Atsushi
A
Tomokiyo
Department of Endodontology, Kyushu University Hospital, Fukuoka, Japan.
Naohisa
N
Wada
Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Katsuaki
K
Koori
Department of Materials, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Giichiro
G
Kawachi
Department of Endodontology, Kyushu University Hospital, and Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Akifumi
A
Akamine
D000818:Animals; D006801:Humans; D010519:Periodontium / Q000254:growth & development* / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*; D023822:Tissue Engineering; D014070:Tooth / Q000033:anatomy & histology / Q000502:physiology; D018677:Tooth Injuries / Q000473:pathology*