[Advances in genes and molecular markers of pheochromocytoma].
Pheochromocytoma is a tumor derived from chromaffin tissue in the adrenergic system with excessive secretion of catecholamine.Pheochromocytoma occurs at any age of patients,commonly in 40-60 years,and the incidence is slightly higher in women than in men.In recent years,studies have shown that the mutations of von Hippel-Lindau gene (VHL),rearranged during transfection gene (RET),neurofibromatosis type 1 gene (NF-1),succinate dehydrogenase gene (SDH),transmembrane protein 127 gene (TMEM127),myelocytomatosis oncogene-associated factor X gene (MAX) are associated with pheochromocytoma.Immunohistochemical studies have revealed that a number of molecular markers,such as telomerase,vascular endothelial growth factor,cyclooxygenase-2,adrenomedullin,plasma chromaffin protein A,signal transducer and activator of transcription-3 are of value in identification of tumor origin,its biological behaviors and differentiation of pheochromocytoma. This article reviews the newest research progresses in molecular biology of pheochromocytoma.
Department of Cardiology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China.
Shi-kun
SK
Gong
Department of Cardiology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China.
Zhong
Z
Liu
D000310:Adrenal Gland Neoplasms / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics; D006801:Humans; D009154:Mutation; D010673:Pheochromocytoma / Q000235:genetics*
D014408:Biomarkers, Tumor