Enantio-differentiation of O-heterocycles using a binol-derived disulfonimide as a chiral solvating agent.
The disulfonimide (R)-1 enables enantio-differentiation of a large scope of chiral O-heterocycles, thanks to the formation of diastereomeric adducts. The underlying H-bond has been investigated by NMR. (R)-1 has been used as a chiral solvating agent (CSA) to determine the stereochemical purity of D/L lactide by (1)H NMR.
LHFA, CNRS UMR 5069, University of Toulouse, 118 route de Narbonne, F-31062 Toulouse, France. dbouriss@chimie.ups-tlse.fr bmv@chimie.ups-tlse.fr.
A
A
Couffin
O
O
Thillaye du Boullay
M
M
Vedrenne
C
C
Navarro
B
B
Martin-Vaca
D
D
Bourissou