The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants.
The impact of nutrition and energy reserves on the fertility of ruminants has been extensively described. However, the metabolic factors and the molecular mechanisms involved in the interactions between nutrition and ovarian function are still poorly understood. These factors could be hormonal (either reproductive and/or metabolic) and/or dietary and metabolic (glucose, amino acids and fatty acids). In this review, we briefly summarize the impact of those nutrients (fatty acids, glucose and amino acids) and metabolic hormones (insulin/IGF-I, growth hormone, T3/4, ghrelin, apelin and the adipokines (leptin, adiponectin and resistin)) implicated in the development of ovarian follicles, oocytes and embryos in ruminants. We then discuss the current hypotheses on the mechanisms of action of these factors on ovarian function. We particularly describe the role of some energy sensors including adenosine monophosphate-activated kinase and peroxisome proliferator-activated receptors in the ovarian cells.
1INRA,UMR85 Physiologie de la Reproduction et des Comportements,F-37380 Nouzilly,France.
J
J
Dupont
1INRA,UMR85 Physiologie de la Reproduction et des Comportements,F-37380 Nouzilly,France.
R J
RJ
Scaramuzzi
1INRA,UMR85 Physiologie de la Reproduction et des Comportements,F-37380 Nouzilly,France.
M
M
Reverchon
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D009865:Oocytes / Q000378:metabolism; D006080:Ovarian Follicle / Q000378:metabolism; D012418:Ruminants / Q000196:embryology* / Q000502:physiology