Composite films of poly(vinyl alcohol)-chitosan-bacterial cellulose for drug controlled release.
Mono and multilayer composite films of poly(vinyl alcohol)-chitosan-bacterial cellulose (PVA/chitosan/BC) have been prepared to achieve controlled release of ibuprofen sodium salt (IbuNa) as model drug. The composite films have been characterized by Fourier transformed infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Surface morphology was investigated by scanning electron microscopy (SEM). Equilibrium swelling was measured in water at two different pH values and in vitro release of IbuNa in pH 1.2 and pH 7.4 media was studied. The release experiments revealed that drug release is pH sensitive. The release kinetics of IbuNa could be described by the Fickian model of diffusion with a good agreement. The IbuNa release rate was decreasing for all the films as the BC concentration was increased in the films composition, the decrease being higher for the multilayer films.
University "Politehnica" of Bucharest, Faculty of Applied Chemistry and Material Science, Polizu 1-3, Bucharest 011061, Romania.
Ramona-Daniela
RD
Pavaloiu
University "Politehnica" of Bucharest, Faculty of Applied Chemistry and Material Science, Polizu 1-3, Bucharest 011061, Romania.
Anicuta
A
Stoica-Guzun
University "Politehnica" of Bucharest, Faculty of Applied Chemistry and Material Science, Polizu 1-3, Bucharest 011061, Romania. Electronic address: marta_stroescu@yahoo.com.
Marta
M
Stroescu
University "Politehnica" of Bucharest, Faculty of Applied Chemistry and Material Science, Polizu 1-3, Bucharest 011061, Romania.
Sorin Ion
SI
Jinga
University "Politehnica" of Bucharest, Faculty of Applied Chemistry and Material Science, Polizu 1-3, Bucharest 011061, Romania.
Tanase
T
Dobre
D001419:Bacteria / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D011142:Polyvinyl Alcohol; D002482:Cellulose; D048271:Chitosan; D007052:Ibuprofen
Bacterial cellulose; Chitosan; Drug release; Ibuprofen sodium salt; Poly(vinyl alcohol)