Prognostic relevance of plasma heart-type fatty acid binding protein after out-of-hospital cardiac arrest.
OBJECTIVE
Heart-type fatty acid binding protein (H-FABP) is a tissue-specific protein which is rapidly released into the circulation when cardiomyocyte injury occurs. The aim of the study is to investigate the prognostic relevance of H-FABP for out-of-hospital cardiac arrest (OHCA) patients in the early post-cardiac arrest period.


METHODS
This is a prospective cohort study enrolling non-traumatic resuscitated OHCA patients.


RESULTS
A total of 106 patients were enrolled. The H-FABP level at 24h was correlated to the duration from collapse to return of spontaneous circulation (p<0.001, R(2)=0.549). The outcomes of survival to discharge were worse in the patient group with the higher tertile of plasma H-FABP level at 24h after the event (p=0.011). Multivariate analysis demonstrated that the significant predictors for in-hospital mortality were APACHE II score (p=0.010), gender (p=0.025) and the tertiles of H-FABP at 24h with hazard ratios for the lowest, middle, and highest tertiles being 1.0, 1.157 (95% confidence interval 0.435-3.075, p=0.770), and 2.840 (95% confidence interval 1.137-7.092, p=0.025), respectively.


CONCLUSIONS
The plasma level of H-FABP at 24h after the event may be an early and independent factor associated with survival to discharge in OHCA patients.
Department of Emergency Medicine, National Taiwan University Hospital, National Taiwan University Medical College, Taipei, Taiwan; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University Medical College, Taipei, Taiwan.
Chien-Hua
CH
Huang
Department of Emergency Medicine, National Taiwan University Hospital, National Taiwan University Medical College, Taipei, Taiwan.
Min-Shan
MS
Tsai
Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
Kuo-Liong
KL
Chien
Department of Emergency Medicine, National Taiwan University Hospital, National Taiwan University Medical College, Taipei, Taiwan.
Chiung-Yuan
CY
Hsu
Department of Emergency Medicine, National Taiwan University Hospital, National Taiwan University Medical College, Taipei, Taiwan.
Wei-Tien
WT
Chang
Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University Medical College, Taipei, Taiwan.
Tzung-Dau
TD
Wang
Department of Emergency Medicine, National Taiwan University Hospital, National Taiwan University Medical College, Taipei, Taiwan.
Shyr-Chyr
SC
Chen
Department of Emergency Medicine, National Taiwan University Hospital, National Taiwan University Medical College, Taipei, Taiwan.
Matthew Huei-Ming
MH
Ma
Department of Emergency Medicine, National Taiwan University Hospital, National Taiwan University Medical College, Taipei, Taiwan; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University Medical College, Taipei, Taiwan. Electronic address: wjchen1955@ntu.edu.tw.
Wen-Jone
WJ
Chen
D000368:Aged; D015415:Biomarkers / Q000097:blood; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D058687:Out-of-Hospital Cardiac Arrest / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D012151:Resuscitation; D016019:Survival Analysis; D013997:Time Factors
D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins
Heart-type fatty acid binding protein; Out-of-hospital cardiac arrest; Outcome; Prognosis; Troponin I