A single nucleotide polymorphism in SLC1A1 gene is associated with age of onset of obsessive-compulsive disorder.
Different genetic polymorphisms in the SLC1A1 have been shown to be associated with obsessive-compulsive disorder. Rs301430 is a T/C functional polymorphism affecting the gene expression and extrasynaptic glutamate concentration.We observed that Rs301430 influence age at onset in obsessive-compulsive disorder.
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy. Electronic address: dallaspezia.sara@hsr.it.
S
S
Dallaspezia
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy.
M
M
Mazza
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy.
C
C
Lorenzi
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy.
F
F
Benedetti
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy.
E
E
Smeraldi
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D050580:Excitatory Amino Acid Transporter 3 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
D050580:Excitatory Amino Acid Transporter 3; C493400:SLC1A1 protein, human
Age at onset; Glutamate; Obsessive-compulsive disorder; Rs301430; SLC1A1