Regulation of mitochondrial morphology by lipids.
Although great progress has been made in identifying key protein factors that regulate mitochondrial morphology through mediating fission and fusion, signaling lipids are increasingly being recognized as important in the process as well. We review here roles that have been proposed for the signaling and bulk lipids cardiolipin, phosphatidic acid, lysophosphatidic acid, diacylglycerol, and phosphatidylethanolamine and the enzymes that generate or catabolize them in the regulation of mitochondrial morphology in yeast and mammals. Mutations in some of these enzymes are causal in a number of disease settings, highlighting the significance of controlling the lipid environment in this setting.
Center for Developmental Genetics, Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA.
Elizabeth E-J
EE
Ha
Michael A
MA
Frohman
D000818:Animals; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*; D063154:Mitochondrial Dynamics; D053142:Mitochondrial Size
D008055:Lipids
cardiolipin; fission; fusion; mitochondria; phosphatidic acid