Haemolytic anaemia after nitrofurantoin treatment in a pregnant woman with G6PD deficiency.
We present a normotensive, pregnant woman with severe haemolytic anaemia in the third trimester of pregnancy. Owing to normal platelet count diagnoses other than HELLP syndrome were considered and investigated. The patient was treated with nitrofurantoin 3 weeks before presentation and she turned out to have a deficiency of glucose-6-phosphate dehydrogenase. After treatment with blood transfusion, vitamin B12 and folic acid the patient recovered completely. Caesarean delivery was performed because of maternal hypertension and fetal distress at 33 weeks' gestation.
Department of Obstetrics & Gynecology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
Lidewij
L
van de Mheen
Simone M
SM
Smits
Wim E
WE
Terpstra
Anja
A
Leyte
Dick J
DJ
Bekedam
Eline S A
ES
van den Akker
D000328:Adult; D000743:Anemia, Hemolytic / Q000175:diagnosis* / Q000628:therapy; D001803:Blood Transfusion / Q000379:methods; D002585:Cesarean Section / Q000379:methods; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000175:diagnosis* / Q000628:therapy; D017359:HELLP Syndrome / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D009582:Nitrofurantoin / Q000627:therapeutic use*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000628:therapy*; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D011295:Prenatal Care / Q000379:methods; D018570:Risk Assessment; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000188:drug therapy; D014805:Vitamin B 12 / Q000627:therapeutic use
D009582:Nitrofurantoin; D005492:Folic Acid; D014805:Vitamin B 12