The clinical significance of pregnancy in Brugada syndrome.
OBJECTIVE
Little is known about the risks and outcomes of pregnancy in women with Brugada syndrome. We therefore evaluated pregnancy outcomes and the influence of pregnancy in patients with Brugada syndrome.


METHODS
A retrospective analysis was performed in all pregnant women with Brugada syndrome. We included 104 women with a total of 219 deliveries.


RESULTS
There were 15 spontaneous abortions. One infant died suddenly during the night 3 months after birth. Six pregnant women reported they had experienced at least 1 syncope during the pregnancy. Of the 3 women who received an implantable cardioverter-defibrillator before the pregnancy, none received arrhythmia episodes. There were no events during the pregnancy in 4 patients with a previously aborted sudden cardiac death. Of 24 patients with syncope when not pregnant, 18 were asymptomatic and 6 experienced a recurrent syncope during the pregnancy. During the follow-up (mean follow-up 298.9 days; 95% confidence interval, 289.6-308.2), 2 women received appropriate shocks.


CONCLUSIONS
In this retrospective, single-center study, serious events were not more frequent during pregnancy and the peripartum period in women with Brugada syndrome. The occurrence of syncope during pregnancy was not associated with a worst outcome in the peri- and postpartum periods or during follow-up. The reported rate of miscarriage and sudden infant death will require further studies to confirm or rule out its association with Brugada syndrome.
Heart Rhythm Management Center, University Hospital Brussels-UZB, Brussels, Belgium. Electronic address: moirmanero@gmail.com.
Moisés
M
Rodríguez-Mañero
Heart Rhythm Management Center, University Hospital Brussels-UZB, Brussels, Belgium.
Rubén
R
Casado-Arroyo
Heart Rhythm Management Center, University Hospital Brussels-UZB, Brussels, Belgium.
Andrea
A
Sarkozy
Heart Rhythm Management Center, University Hospital Brussels-UZB, Brussels, Belgium.
Eva
E
Leysen
Heart Rhythm Management Center, University Hospital Brussels-UZB, Brussels, Belgium.
Juan Antonio
JA
Sieira
Heart Rhythm Management Center, University Hospital Brussels-UZB, Brussels, Belgium.
Mehdi
M
Namdar
Heart Rhythm Management Center, University Hospital Brussels-UZB, Brussels, Belgium.
Gulio
G
Conte
Heart Rhythm Management Center, University Hospital Brussels-UZB, Brussels, Belgium.
Moisés
M
Levinstein
Heart Rhythm Management Center, University Hospital Brussels-UZB, Brussels, Belgium.
Gian-Battista
GB
Chierchia
Heart Rhythm Management Center, University Hospital Brussels-UZB, Brussels, Belgium.
Carlo
C
de Asmundis
Heart Rhythm Management Center, University Hospital Brussels-UZB, Brussels, Belgium.
Pedro
P
Brugada
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D001530:Belgium / Q000453:epidemiology; D053840:Brugada Syndrome / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D013398:Sudden Infant Death / Q000453:epidemiology; D013575:Syncope / Q000453:epidemiology
Brugada syndrome; Embarazo; Pregnancy; Sudden infant death syndrome; Sudden unexpected death syndrome; Síndrome de Brugada; Síndrome de muerte súbita inesperada; Síndrome de muerte súbita infantil