[Characteristics of antibiotic therapy in neonates with polyorgan insufficiency].
Polyorgan insufficiency (POI) is the main cause of death in ISU patients. The highest rates of morbidity and mortality due to POI are recorded among newborns. Antibbacterial therapy of probable infections processes is widely used in neonatology, however long-term antibacterial therapy is not favouable for newborn infants. The aim of the present study was to investigate the peculiarities of antibacterial therapy in newborn with POI. The trial enrolled 453 infants antibacterial therapy was used in all of them (100%). The most frequent drugs used in the treatment were the III and IV generation cephalosporines and aminoglycosides. The POI antibacterial therapy in severe cases was more intensive and prolonged. The most long-term therapy was applied to newborns weighting 1500 g. Recovery of the organ function served as a criterion for discontinuation of the antibacterial therapy. Antibacterial of neonate infants with POI requires optimization.
E N
EN
Serebriakova
D K
DK
Volosnikov
G A
GA
Glazyrina
D000617:Aminoglycosides / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D002511:Cephalosporins / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D007902:Length of Stay; D008297:Male; D009102:Multiple Organ Failure / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D016019:Survival Analysis
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins