Asymmetric 1,3-dipolar cycloadditons of stabilized azomethine ylides with nitroalkenes.
This review highlights the biological importance of many polysubstituted nitro-prolines and -pyrrolidines. Their preparation using asymmetric 1,3-dipolar cycloadditions of azomethine ylides with nitroalkenes using diastereoselective and enantioselective strategies is described remarking the scope and main features of each one.
Carmen
C
Nejera
Departamento de Quimica Organica and Instituto de Sintesis Organica (ISO). Universidad de Alicante, E-03080-Alicante, Spain. cnajera@ua.es.
Jose M
JM
Sansano
D000475:Alkenes / Q000737:chemistry*; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D008958:Models, Molecular; D008968:Molecular Conformation; D009574:Nitro Compounds / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry
D000475:Alkenes; D001391:Azo Compounds; D009574:Nitro Compounds; D013882:Thiosemicarbazones; C512188:azomethine