Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity.
Recent findings, notably on adipokines and adipose tissue inflammation, have revised the concept of adipose tissues being a mere storage depot for body energy. Instead, adipose tissues are emerging as endocrine and immunologically active organs with multiple effects on the regulation of systemic energy homeostasis. Notably, compared with other metabolic organs such as liver and muscle, various inflammatory responses are dynamically regulated in adipose tissues and most of the immune cells in adipose tissues are involved in obesity-mediated metabolic complications, including insulin resistance. Here, we summarize recent findings on the key roles of innate (neutrophils, macrophages, mast cells, eosinophils) and adaptive (regulatory T cells, type 1 helper T cells, CD8 T cells, B cells) immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. In particular, the roles of natural killer T cells, one type of innate lymphocyte, in adipose tissue inflammation will be discussed. Finally, a new role of adipocytes as antigen presenting cells to modulate T cell activity and subsequent adipose tissue inflammation will be proposed.
School of Biological Science, Institute of Molecular Biology and Genetics, Korea.
Jin Young
JY
Huh
Department of Biophysics and Chemical Biology, Seoul National University, Seoul 151-742, Korea.
Yoon Jeong
YJ
Park
Mira
M
Ham
Jae Bum
JB
Kim
D017667:Adipocytes / Q000502:physiology*; D052436:Adipose Tissue, White / Q000276:immunology / Q000473:pathology*; D000818:Animals; D004804:Eosinophils / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007333:Insulin Resistance / Q000276:immunology; D008214:Lymphocytes / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D008407:Mast Cells / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D009765:Obesity / Q000276:immunology* / Q000473:pathology