Spongy film of cellulosic polysaccharide as a dressing for aphthous stomatitis treatment in rabbits.
OBJECTIVE
To develop an experimental model of acute inflammation, like aphthous ulcers, in oral cavity of rabbits, and also, to evaluate the results of the application of a polysaccharide spongy film of molasses from sugar cane as assist treatment in the healing process.


METHODS
Twenty adult rabbits weighting between 2.5 kg and 3.9 kg were divided into two groups: experimental and control infected ulcers were induced on the jugal mucosa by surgical excision. They were treated at the experimental group by curettage and dressing with spongy film of cellulosic polysaccharide film, whereas saline solution was used in the control group. Temporal evolution of the healing area, histopathology and bacteriological analysis were used to evaluate the healing process on the 3rd (D3), 7th (D7) and 11th days (D11).


RESULTS
The healing time and bacteriological study showed no statistical differences on the group means. Analyzing the histopathology of the experimental group we verified epithelial hyperplasia from D3 to D11, instead in the control group there was a greater clutter of the epithelial cells from the D3 to D11.


CONCLUSIONS
The experimental model used caused aphthous ulcers and the polysaccharide sponge film can be used as an aid in the symptomatic treatment and healing of the ulcerative lesions of the oral mucosa.
Pernambuco Federal University, Recife, PE, Brazil.
Fernanda Mossumez
FM
Fernandes Teixeira
Department of Pathology, Veterinary Hospital, Pernambuco Federal Rural University, Recife, PE, Brazil.
Márcia de
Md
Figueiredo Pereira
UFPE, Recife, PE, Brazil.
Nara Lins
NL
Gomes Ferreira
UFPE, Recife, PE, Brazil.
Guilherme Marcelino de
GM
Miranda
Department of Surgery, UFPE, Recife, PE, Brazil.
José Lamartine de
JL
Andrade Aguiar
D000818:Animals; D047070:Bandages, Hydrocolloid; D002482:Cellulose / Q000627:therapeutic use*; D023421:Models, Animal; D011817:Rabbits; D015203:Reproducibility of Results; D013281:Stomatitis, Aphthous / Q000473:pathology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*
D002482:Cellulose