Relationships between abnormal MMP2 expression and prognosis in gastric cancer: a meta-analysis of cohort studies.
We carried out this current meta-analysis of relevant cohort studies in an attempt to investigate the relationships between abnormal matrix metalloproteinases-2 (MMP2) expression and gastric cancer (GC) prognosis. A range of electronic databases were searched for relevant articles without any language restrictions: Web of Science (1945-2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966-2013), EMBASE (1980-2013), CINAHL (1982-2013), and the Chinese Biomedical Database (CBM) (1982-2013). Meta-analysis was conducted using the STATA 12.0 software. Crude hazard ratios (HRs), with 95% confidence intervals (95% CIs), were calculated. Ten clinical cohort studies with a total of 1669 GC patients were included in this meta-analysis. The results of our meta-analysis suggested that MMP2-positive patients display a shorter overall survival (OS) than MMP2-negative patients (HR=1.31, 95% CI=0.98-1.63, p<0.001). Subgroup analysis based on ethnicity revealed that abnormal MMP2 expression was associated with significantly worse OS in patients with GC among both Caucasian and Asian populations (all p<0.05). Our meta-analysis indicated that abnormal MMP2 expression may be strongly correlated with poor prognosis in patients with GC. Thus, MMP2 expression may serve as an independent prognostic factor for GC.
Department of General Surgery, Shengjing Hospital of China Medical University , Shenyang, People's Republic of China .
He-Ling
HL
Wang
Ping-Yi
PY
Zhou
Yu
Y
Zhang
Peng
P
Liu
D014408:Biomarkers, Tumor / Q000096:biosynthesis; D015331:Cohort Studies; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000201:enzymology*
D014408:Biomarkers, Tumor; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2
gastric cancer; matrix metalloproteinases-2; meta-analysis; prognosis