Performance of eHealth data sources in local influenza surveillance: a 5-year open cohort study.
BACKGROUND
There is abundant global interest in using syndromic data from population-wide health information systems--referred to as eHealth resources--to improve infectious disease surveillance. Recently, the necessity for these systems to achieve two potentially conflicting requirements has been emphasized. First, they must be evidence-based; second, they must be adjusted for the diversity of populations, lifestyles, and environments.


OBJECTIVE
The primary objective was to examine correlations between data from Google Flu Trends (GFT), computer-supported telenursing centers, health service websites, and influenza case rates during seasonal and pandemic influenza outbreaks. The secondary objective was to investigate associations between eHealth data, media coverage, and the interaction between circulating influenza strain(s) and the age-related population immunity.


METHODS
An open cohort design was used for a five-year study in a Swedish county (population 427,000). Syndromic eHealth data were collected from GFT, telenursing call centers, and local health service website visits at page level. Data on mass media coverage of influenza was collected from the major regional newspaper. The performance of eHealth data in surveillance was measured by correlation effect size and time lag to clinically diagnosed influenza cases.


RESULTS
Local media coverage data and influenza case rates showed correlations with large effect sizes only for the influenza A (A) pH1N1 outbreak in 2009 (r=.74, 95% CI .42-.90; P<.001) and the severe seasonal A H3N2 outbreak in 2011-2012 (r=.79, 95% CI .42-.93; P=.001), with media coverage preceding case rates with one week. Correlations between GFT and influenza case data showed large effect sizes for all outbreaks, the largest being the seasonal A H3N2 outbreak in 2008-2009 (r=.96, 95% CI .88-.99; P<.001). The preceding time lag decreased from two weeks during the first outbreaks to one week from the 2009 A pH1N1 pandemic. Telenursing data and influenza case data showed correlations with large effect sizes for all outbreaks after the seasonal B and A H1 outbreak in 2007-2008, with a time lag decreasing from two weeks for the seasonal A H3N2 outbreak in 2008-2009 (r=.95, 95% CI .82-.98; P<.001) to none for the A p H1N1 outbreak in 2009 (r=.84, 95% CI .62-.94; P<.001). Large effect sizes were also observed between website visits and influenza case data.


CONCLUSIONS
Correlations between the eHealth data and influenza case rates in a Swedish county showed large effect sizes throughout a five-year period, while the time lag between signals in eHealth data and influenza rates changed. Further research is needed on analytic methods for adjusting eHealth surveillance systems to shifts in media coverage and to variations in age-group related immunity between virus strains. The results can be used to inform the development of alert-generating eHealth surveillance systems that can be subject for prospective evaluations in routine public health practice.
Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. toomas.timpka@liu.se.
Toomas
T
Timpka
Armin
A
Spreco
Örjan
Ö
Dahlström
Olle
O
Eriksson
Elin
E
Gursky
Joakim
J
Ekberg
Eva
E
Blomqvist
Magnus
M
Strömgren
David
D
Karlsson
Henrik
H
Eriksson
James
J
Nyce
Jorma
J
Hinkula
Einar
E
Holm
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002675:Child, Preschool; D015331:Cohort Studies; D003625:Data Collection; D004196:Disease Outbreaks; D063005:Health Information Systems; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype; D053122:Influenza A Virus, H3N2 Subtype; D007251:Influenza, Human / Q000453:epidemiology*; D020407:Internet; D008402:Mass Media; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D057386:Search Engine; D013548:Sweden / Q000453:epidemiology; D017216:Telemedicine; D055815:Young Adult
Google Flu Trends; Internet; eHealth; infectious disease surveillance; influenza; open cohort design; public health; telenursing call centers; website usage