Enzymatic preparation of a redox-responsive hydrogel for encapsulating and releasing living cells.
Horseradish peroxidase-mediated oxidative cross-linking of a thiolated poly(ethylene glycol) is promoted in the absence of exogenous hydrogen peroxide, by adding a small amount of a phenolic compound under physiological conditions. The prepared hydrogel can encapsulate and release living mammalian cells.
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Fukuoka 819-0395, Japan. nori_kamiya@mail.cstm.kyushu-u.ac.jp.
Kousuke
K
Moriyama
Kosuke
K
Minamihata
Rie
R
Wakabayashi
Masahiro
M
Goto
Noriho
N
Kamiya
D000818:Animals; D002460:Cell Line; D006735:Horseradish Peroxidase / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D051379:Mice; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry
D020100:Hydrogels; D010636:Phenols; D011092:Polyethylene Glycols; D006735:Horseradish Peroxidase