Overview of the preparation of organic polymeric nanoparticles for drug delivery based on gelatine, chitosan, poly(d,l-lactide-co-glycolic acid) and polyalkylcyanoacrylate.
Polymeric nanoparticles are greatly advancing the field of nanomedicine due to their ability for targeted and controlled drug release. There are two types of materials which form polymeric nanoparticles; natural or synthetic. In this review article, natural polymeric nanoparticles including; gelatine and chitosan and synthetic polymeric nanoparticles such as poly(lactide-co-glycolic acid) and poly-n-alkyl(cyano)acrylate will be discussed. The various preparation methods of these nanoparticles and the impact of critical parameters such as molecular weight, charge or choice of stabilizer will be described, as these control the overall mean size and surface of the nanoparticle which is a critical factor for drug delivery.
Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Patrick
P
Lai
Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Weiam
W
Daear
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Raimar
R
Löbenberg
Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada. Electronic address: eprenner@ucalgary.ca.
Elmar J
EJ
Prenner
D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D003487:Cyanoacrylates / Q000737:chemistry*; D016503:Drug Delivery Systems; D005780:Gelatin / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
D003487:Cyanoacrylates; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005780:Gelatin; D048271:Chitosan
Chitosan; Cyanoacrylate; Gelatine; Nanoparticle synthesis; PLGA