Palladium-catalyzed C(sp²)-H arylation using formamide as a transformable directing group.
A new process for the ortho arylation of formanilides through palladium-catalyzed C-H activation is described. Formamide is reported as a transformable directing group in the transition-metal-catalyzed C-H functionalization reaction. The resulting biarylformanilide products can be readily transformed to the corresponding biarylisocyanides or N-heterocycles.
Department of Bioengineering, College of Life Science and Technology, Jinan University , Guangzhou 510632, China.
Congqing
C
Wan
Jiaji
J
Zhao
Mingfang
M
Xu
Jinbo
J
Huang
D002384:Catalysis; D005559:Formamides / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry*
D005559:Formamides; D006571:Heterocyclic Compounds; D009570:Nitriles; D028561:Transition Elements; D010165:Palladium