Neurodevelopment, GABA system dysfunction, and schizophrenia.
The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and Bleuler began documenting their findings. However, large clinical research efforts in recent decades have identified numerous genetic and environmental risk factors for schizophrenia. The combined data strongly support the neurodevelopmental hypothesis of schizophrenia and underscore the importance of the common converging effects of diverse insults. In this review, we discuss the evidence that genetic and environmental risk factors that predispose to schizophrenia disrupt the development and normal functioning of the GABAergic system.
Department of Psychiatry, Vanderbilt University, Nashville, TN, USA.
Martin J
MJ
Schmidt
1] Department of Psychiatry, Vanderbilt University, Nashville, TN, USA [2] Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN, USA [3] Department of Psychiatry, University of Szeged, Szeged, Hungary.
Karoly
K
Mirnics
D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000503:physiopathology*; D006801:Humans; D018079:Receptors, GABA / Q000502:physiology*; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid