Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections.
This study described the cerebrospinal fluid (CSF) exposure of vancomycin in 8 children prescribed intravenous vancomycin therapy for cerebral ventricular shunt infection. Vancomycin CSF concentrations ranged from 0.06 to 9.13 mg/L and the CSF: plasma ratio ranged from 0 to 0.66. Two of 3 children with a staphylococcal CSF infection had CSF concentrations greater than minimal inhibitory concentration at the end of the dosing interval.
From the *Duke Clinical Research Institute; †Department of Pediatrics, Duke University, Durham; ‡Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC; §Department of Pediatric Pharmacology, University of California, San Diego, CA; and ¶Department of Neurosurgery, Duke University, Durham, NC.
Julie
J
Autmizguine
Cassie
C
Moran
Daniel
D
Gonzalez
Edmund V
EV
Capparelli
P Brian
PB
Smith
Gerald A
GA
Grant
Daniel K
DK
Benjamin
Michael
M
Cohen-Wolkowiez
Kevin M
KM
Watt
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002555:Cerebrospinal Fluid / Q000737:chemistry; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D011446:Prospective Studies; D014640:Vancomycin / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D014640:Vancomycin