Plasmacytoid dendritic cells of the gut: relevance to immunity and pathology.
Plasmacytoid dendritic cells (pDCs) are bone marrow-derived immune cells with the ability to express copious amounts of type I and III interferon (IFN) and can differentiate into antigen-presenting dendritic cells as a result of stimulation by pathogen-derived nucleic acid. These powerful combined functionalities allow pDCs to bridge the innate and adaptive immune systems resulting in a concerted pathogen response. The contribution of pDCs to gastrointestinal immunity is only now being elucidated and is proving to be a critical component in systemic immunity. This review will explore the immunology of pDCs and will discuss their involvement in human disease and tolerance with an emphasis on those in the gastrointestinal lymphoid tissue.
Department of Biochemistry and Molecular Biology, University of Nevada School of Medicine, WPI, University of Nevada, Reno, 1664 N Virginia St. MS 0552, Reno, NV 89557, USA. Electronic address: vlombardi@medicine.nevada.edu.
Vincent C
VC
Lombardi
Department of Biochemistry and Molecular Biology, University of Nevada School of Medicine, WPI, University of Nevada, Reno, 1664 N Virginia St. MS 0552, Reno, NV 89557, USA; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia. Electronic address: svkhaiboullina@gmail.com.
Svetlana F
SF
Khaiboullina
D056704:Adaptive Immunity; D000818:Animals; D017951:Antigen Presentation; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000166:cytology* / Q000276:immunology*; D006801:Humans; D010581:Peyer's Patches / Q000276:immunology / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism
D016207:Cytokines; D051193:Toll-Like Receptors
Autoimmunity; GALT;; Gut;; Interferon;; Tolerance;; pDC;