Effects of S. officinalis L. radix triterpene glycosides on innate immunity factors.
The effects of triterpene glycosides (saponins) extracted from Saponaria officinalis L. radices, on the cellular and humoral innate immunity factors were studied. Saponins stimulated the phagocytic, bactericidal, and adhesion activities of polymorphonuclear leukocytes. Optimal conditions of saponin treatment (dose and duration) were determined for mice. Saponins promoted the maturation of human peripheral blood dendritic cells, which was proven by high expression of CD83 (terminal differentiation marker) and CD86 (bone-stimulating molecule) and of HLA-DR and HLA-ABC molecules on the cell membrane. Saponins modulated the production of TNF-α, IL-1β, IL-4, IL-6, and IFN-γ in cultured peripheral blood intact cells. The results help to understand some mechanisms of the effects of saponins extracted from Saponaria officinalis L. radix on the cellular and humoral factors of innate immunity and demonstrate good prospects of their practical use.
Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia, takuznets@mail.ru.
T A
TA
Kuznetsova
L A
LA
Ivanushko
I D
ID
Makarenkova
E I
EI
Cherevach
L A
LA
Ten'kovskaya
D000818:Animals; D002478:Cells, Cultured; D006027:Glycosides / Q000737:chemistry; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D029750:Saponaria / Q000187:drug effects*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes