Urethral dysfunction due to alloxan-induced diabetes. Urodynamic evaluation and action of sildenafil citrate.
OBJECTIVE
To evaluate the effect of diabetes mellitus and of sildenafil citrate on female urethral function.


METHODS
Twenty nine female rats were divided into four groups: G1 - (n=9), normal rats; G2 - (n=6), normal rats treated with sildenafil citrate; G3 - (n=9) rats with alloxan-induced diabetes; G4 - (n=5) rats with alloxan-induced diabetes treated with sildenafil citrate. Under anesthesia, urodynamic evaluation was performed by cystometry and urethral pressure simultaneously.


RESULTS
A significant increase in urethral pressure was observed during micturition.


CONCLUSIONS
Sildenafil citrate can partially reduced urethral pressure in diabetic female rats.
Department of Surgery and Anatomy, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Ana Beatriz
AB
Gomes de Souza Pegorare
Department of Surgery and Anatomy, FMRP, USP, Ribeirao Preto, SP, Brazil.
Marco Antonio
MA
Gonçalves
Department of Surgery and Anatomy, FMRP, USP, Ribeirao Preto, SP, Brazil.
Alessandra
A
Martiniano de Oliveira
Department of Surgery and Anatomy, FMRP, USP, Ribeirao Preto, SP, Brazil.
Antonio Antunes
AA
Rodrigues Junior
Department of Surgery and Anatomy, FMRP, Ribeirao Preto, SP, Brazil.
Silvio
S
Tucci
Department of Surgery and Anatomy, FMRP, USP, Ribeirao Preto, SP, Brazil.
Haylton Jorge
HJ
Suaid
D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000503:physiopathology; D005260:Female; D009569:Nitric Oxide / Q000378:metabolism; D058986:Phosphodiesterase 5 Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011312:Pressure; D011687:Purines / Q000494:pharmacology; D011897:Random Allocation; D017208:Rats, Wistar; D015203:Reproducibility of Results; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000494:pharmacology*; D013997:Time Factors; D016896:Treatment Outcome; D014521:Urethra / Q000187:drug effects / Q000503:physiopathology*; D014554:Urination / Q000187:drug effects; D014563:Urodynamics / Q000187:drug effects* / Q000502:physiology
D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D009569:Nitric Oxide; D000496:Alloxan; D000068677:Sildenafil Citrate