Methicillin-susceptible Staphylococcus aureus CC398: first description in prosthetic joint infection and genetic background comparison with nasal carriage isolates.
Few reports described infections with CC398 methicillin-susceptible Staphylococcus aureus (MSSA). We compared the genetic background of CC398 MSSA strains from nasal carriage and knee arthroplasty infection. DNA microarray analysis shows acquisition of particular adhesin, iron capture system and immune defense evasion mechanisms. These characteristics could explain pathogenesis in this type of infection.
EA3826, Thérapeutiques cliniques et expérimentales des infections - Faculté de Médecine, Nantes, France; Service de Bactériologie-Hygiène hospitalière, CHU de Nantes, France.
Guillaume G
GG
Aubin
EA3826, Thérapeutiques cliniques et expérimentales des infections - Faculté de Médecine, Nantes, France; Service de Bactériologie-Hygiène hospitalière, CHU de Nantes, France.
Didier
D
Lepelletier
EA3826, Thérapeutiques cliniques et expérimentales des infections - Faculté de Médecine, Nantes, France; Service de Bactériologie-Hygiène hospitalière, CHU de Nantes, France.
Alain
A
Reynaud
INSERM U1047, Université de Montpellier 1, Nîmes, France; Laboratoire de Bactériologie, CHU Carémeau, Nîmes, France.
Jean-Philippe
JP
Lavigne
EA3826, Thérapeutiques cliniques et expérimentales des infections - Faculté de Médecine, Nantes, France; Service de Bactériologie-Hygiène hospitalière, CHU de Nantes, France. Electronic address: stephane.corvec@chu-nantes.fr.
Stéphane
S
Corvec
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000383:Agriculture; D002353:Carrier State / Q000382:microbiology*; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D008875:Middle Aged; D009296:Nasal Cavity / Q000382:microbiology*; D016459:Prosthesis-Related Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D055815:Young Adult
D004269:DNA, Bacterial
DNA microarray; Livestock associated Staphylococcus aureus CC398; Prosthetic-related infection