Fluoroquinolone- and ceftriaxone-based therapy of community-acquired pneumonia in hospitalized patients: the risk of subsequent isolation of multidrug-resistant organisms.
A retrospective cohort study was performed on 175 adult patients treated for community-acquired pneumonia with moxifloxacin or ceftriaxone/azithromycin in a nonintensive care unit. Both cohorts were very similar with regard to a wide range of characteristics including age, severity of disease, comorbidities, length of stay, and mortality. Multidrug-resistant organisms were subsequently isolated from 6 (15%) moxifloxacin-treated patients and 5 (4%) ceftriaxone/azithromycin-treated patients within 90 days after beginning of therapy (P = .026 on logistic regression analysis).
Division of Infectious Diseases, Department of Medicine, Beth Israel Medical Center, New York, NY.
Robert C
RC
Goldstein
Department of Emergency Medicine, Beth Israel Medical Center, New York, NY.
Gregg
G
Husk
Division of Infectious Diseases, Department of Medicine, Beth Israel Medical Center, New York, NY.
Tomasz
T
Jodlowski
Division of Infectious Diseases, Department of Medicine, Beth Israel Medical Center, New York, NY.
Donna
D
Mildvan
Division of Infectious Diseases, Department of Medicine, Beth Israel Medical Center, New York, NY.
David C
DC
Perlman
Division of Infectious Diseases, Department of Medicine, Beth Israel Medical Center, New York, NY. Electronic address: jorgruhe25@yahoo.com.
Jörg J
JJ
Ruhe
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D002443:Ceftriaxone / Q000627:therapeutic use*; D015331:Cohort Studies; D017714:Community-Acquired Infections / Q000188:drug therapy*; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D012189:Retrospective Studies; D018570:Risk Assessment; D055815:Young Adult
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D002443:Ceftriaxone; D017963:Azithromycin; D000077266:Moxifloxacin
Antibiotic resistance; Community-acquired pneumonia; Treatment