Content of S100b protein, HLDF24 peptide and autoantibodies to these factors as potential biomarkers for arterial hypertension in blood serum of healthy people.
The content of S100b protein, HLDF24 peptide, and autoantibodies to these factors in blood serum was measured in healthy individuals (35-64-year-old men and women) with various levels of "normal" BP. Significant differences in the amount of these molecular factors were found in individuals with various categories of BP. We revealed age-related and gender differences in the content of molecular factors in the serum. Our results indicate that variations in the concentration of S100b, HLDF24, and autoantibodies to these factors in blood serum from adult people can serve as a reliable criterion for the risk of arterial hypertension.
P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia, m.gluden@nphys.ru.
M A
MA
Gruden
E I
EI
Elistratova
M V
MV
Kudrina
V P
VP
Karlina
I S
IS
Deryabina
I M
IM
Semenova
V M
VM
Ryzhov
V V
VV
Sherstnev
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*
D001323:Autoantibodies; D015415:Biomarkers; D009363:Neoplasm Proteins; D010446:Peptide Fragments; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; C091149:cell differentiation factor 8.2-kDa