LINking microRNAs, kidney development, and Wilms tumors.
In this issue of Genes & Development, Urbach and colleagues (pp. 971-982) provide compelling data suggesting a role for LIN28 in the pathogenesis of a significant percentage of Wilms tumors. These data extend our insights in the genetics underlying Wilms tumor development and emphasize the importance of stemness and microRNA-mediated processes in the origins of these tumors.
The Roslin Institute, University of Edinburgh, Midlothian EH23 4RB, United Kingdom;
Peter
P
Hohenstein
Nicholas D
ND
Hastie
D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000503:physiopathology*; D016601:RNA-Binding Proteins / Q000235:genetics*; D013234:Stem Cells / Q000166:cytology*; D009396:Wilms Tumor / Q000235:genetics* / Q000503:physiopathology*
C488352:Lin-28 protein, mouse; D016601:RNA-Binding Proteins
Lin28; Wilms tumor; kidney development