Membranous lipodystrophy: skeletal findings on CT and MRI.
Membranous lipodystrophy, also known as Nasu-Hakola disease, is a rare hereditary condition with manifestations in the nervous and skeletal systems. The radiographic appearance of skeletal lesions has been well described in the literature. However, CT and MRI findings of lesions in the bone have not been documented to date. This report describes the radiographic, CT, MRI, and histopathologic skeletal findings in a case of membranous lipodystrophy. With corroborative pathologic findings, a diagnosis of membranous lipodystrophy on imaging allows for appropriate clinical management of disease manifestations.
Department of Radiology and Imaging, Hospital for Special Surgery, 535 East 70th Street, 3rd Floor, New York, NY, 10021, USA, nwawkao@hss.edu.
O Kenechi
OK
Nwawka
Robert
R
Schneider
Manjula
M
Bansal
Douglas N
DN
Mintz
Joseph
J
Lane
D000328:Adult; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000293:injuries / Q000473:pathology*; D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D004569:Electroencephalography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008060:Lipodystrophy / Q000150:complications / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019964:Mood Disorders / Q000150:complications / Q000473:pathology; D010009:Osteochondrodysplasias / Q000150:complications / Q000175:diagnosis*; D013344:Subacute Sclerosing Panencephalitis / Q000150:complications / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed / Q000379:methods*