Multifunctional PEG-GO/CuS nanocomposites for near-infrared chemo-photothermal therapy.
The synergistic therapy, the combination of photothermal therapy and chemotherapy, has become a potential treatment in the battles with cancer. Here, we developed a synergistic therapy tool that based on CuS nanoparticles-decorated graphene oxide functionalized with polyethylene glycol (PEG-GO/CuS) for cervical cancer treatment. The as-synthesized PEG-GO/CuS nanocomposites with excellent biocompatibility was revealed to have high storage capacity for anticancer drug of doxorubicin (Dox) and high photothermal conversion efficiency, and were effectively employed for the ablation of tumor. In addition, the therapeutic efficacy of Dox-loaded PEG-GO/CuS (PEG-GO/CuS/Dox) nanocomposites was evaluated in vitro and in vivo for cervical cancer therapy. In vitro cell cytotoxicity tests of PEG-GO/CuS/Dox demonstrate about 1.3 and 2.7-fold toxicity than PEG-GO/CuS and free Dox under 5 min irradiation with NIR laser at 1.0 W/cm(2), owing to both PEG-GO/CuS-mediated photothermal ablation and cytotoxicity of light-triggered Dox release. In mouse models, mouse cervical tumor growth was found to be significantly inhibited by the chemo-photothermal effect of PEG-GO/CuS/Dox nanocomposites, resulting in effective tumor reduction. Overall, compared with chemotherapy or photothermal therapy alone, the combined treatment demonstrates better therapeutic efficacy of cancer in vitro and in vivo. These findings highlight the promise of the highly versatile multifunctional nanoparticles in biomedical application.
State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China.
Jing
J
Bai
State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China.
Yuwei
Y
Liu
State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China. Electronic address: jiangxiue@ciac.ac.cn.
Xiue
X
Jiang
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002584:Cervix Uteri / Q000187:drug effects / Q000473:pathology; D003131:Combined Modality Therapy; D003300:Copper / Q000737:chemistry / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006108:Graphite / Q000737:chemistry / Q000627:therapeutic use*; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use*; D010087:Oxides / Q000737:chemistry / Q000627:therapeutic use; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy*
D000903:Antibiotics, Antineoplastic; D010087:Oxides; D011092:Polyethylene Glycols; D006108:Graphite; D003300:Copper; D004317:Doxorubicin; C017846:cupric sulfide
Copper sulfide nanoparticles; Cytotoxicity; Drug delivery; Graphene oxide; Photothermal therapy; Synergistic effect