Monitoring of mercury, arsenic, cadmium and lead in Ayurvedic formulations marketed in Delhi by flame AAS and confirmation by ICP-MS.
The quality and safety of Ayurvedic formulations has become a serious issue, as this Indian system of medicine is used by 80% of the Indian population. Hence, the present study was performed to evaluate heavy metals contents by flame atomic absorbance spectroscopy (AAS) measurements and confirmation by inductive coupled plasma-mass spectroscopy (ICP-MS). A total of 78 formulations (56 herbal, 19 herbometallic and 3 metallic) were sampled. In herbal formulations, lead in 19.6% (11/56), cadmium in 21.4% (12/56), mercury and arsenic in 5.3% (3/56) were above the limit. Lead in 52.6% (10/19) of samples, cadmium in 26.3% (5/19) and mercury and arsenic contained in one herbometallic sample was above the limit. Heavy metals in all metal formulations were above the WHO limit. Significant batch variation was observed. The analytical results of flame AAS and ICP-MS did not differ significantly in the range of measurements in this study, which proves that both methods are satisfactory for estimation of heavy metals in these type of samples.
a Department of Pharmacology , All India Institute of Medical Sciences , New Delhi, 110029 , India.
Gajendra
G
Kumar
Y K
YK
Gupta
D002138:Calibration; D007194:India; D057230:Limit of Detection; D013058:Mass Spectrometry / Q000379:methods*; D008515:Medicine, Ayurvedic; D019216:Metals, Heavy / Q000032:analysis*; D011786:Quality Control; D013054:Spectrophotometry, Atomic / Q000379:methods*
D019216:Metals, Heavy
Ayurvedic formulation; ICP-MS; arsenic; cadmium; flame AAS; heavy metals; lead; mercury