[Recent advances in the study of mechanism of APOBEC3G against virus].
APOBEC3 is a class of cytidine deaminase, which is considered as a new member of the innate immune system, and APOBEC3G belongs to this family. The research about APOBEC3G is a new direction of innate immune defense mechanism against virus. APOBEC3G has the restrictive activity on many viral replications, which deaminates dC to dU in the viral genome and then induces extensive hypermutation. APOBEC3G can also interrupt viral replication at several phases such as reverse transcription, replication, nucleocapsid and so on by non-deamination mechanisms. However, virus can encode viral proteins to counteract the restriction activity of APOBEC3G. Elucidation of the antagonistic interaction between APOBEC3G and the virus will be contributed to development of new antiviral drugs in the future.
Yan-Ping
YP
Zhu
Jian-Dong
JD
Jiang
Zong-Gen
ZG
Peng
D000071480:APOBEC-3G Deaminase; D000818:Animals; D003564:Cytidine Deaminase / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication; D003641:Deamination; D015497:HIV-1 / Q000502:physiology*; D016174:Hepacivirus / Q000235:genetics / Q000502:physiology; D006515:Hepatitis B virus / Q000235:genetics / Q000502:physiology; D006801:Humans; D010252:Paramyxoviridae / Q000235:genetics / Q000502:physiology; D012190:Retroviridae / Q000502:physiology*; D014779:Virus Replication; D054320:vif Gene Products, Human Immunodeficiency Virus / Q000378:metabolism
D054320:vif Gene Products, Human Immunodeficiency Virus; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase