[The impact of antisecretory therapy on gastroduodenal ulcers healing after acute bleeding].
In this paper we compared the efficacy of proton pump inhibitors (PPIs) and H2 receptor antagonists on the morphogenesis of the marginal zone of gastric and duodenal ulcers in 56 patients withacute gastroduodenal bleeding. It is shown that the antisecretory drugs in the treatment of patients with acute ulcerative bleedingnot only affect on the secretory activity of the glands in gastroduodenal zone, but it also modulates inflammatory reparative process and the status of mucous and bicarbonate barrier. A greater anti-inflammatory effect of PPI in comparison with H2-receptor antagonists has been proved. Appointment of PPIs had more pronounced stimulation of angiogenesis and cell proliferation of the surface epithelium.
É F
ÉF
Barinov
P G
PG
Kondratenko
O N
ON
Sulaeva
S O
SO
Zharikov
E E
EE
Radenko
T A
TA
Tverdokhleb
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001706:Biopsy; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D006635:Histamine H2 Antagonists; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic / Q000187:drug effects; D054328:Proton Pump Inhibitors; D013276:Stomach Ulcer / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors