Threshold limits for biological indication of prolonged radiation exposure using mFISH.
Chromosome aberration (translocation) yield was investigated by mFISH in peripheral blood lymphocytes of Mayak Production Association (PA) workers with prolonged occupational exposure to ionizing radiation (IR). A dose threshold for cytogenetic indication of a prolonged occupational radiation exposure was estimated for Mayak PA workers using functions of dose distributions. Two limits were estimated for the indication of IR exposure to workers with a prolonged external gamma-ray exposure: These are a background translocation yield of N₀ = 0.812 ± 0.149% and a dose threshold of indication D₀ estimated to be approximately 1 Gy.
*Southern Urals Biophysics Institute (SUBI), 456780 Ozyorsk, Russian Federation; † Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Munich, GER.
Sergey V
SV
Osovets
Natalia V
NV
Sotnik
Viktor
V
Meineke
Harry
H
Scherthan
Harald
H
Dörr
Tamara V
TV
Azizova
D000368:Aged; D002869:Chromosome Aberrations / Q000528:radiation effects*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D055848:Nuclear Power Plants; D011336:Probability; D018788:Radioactive Hazard Release; D020711:Threshold Limit Values; D013997:Time Factors