Palladium-catalyzed Heck-type cross-couplings of unactivated alkyl iodides.
A palladium-catalyzed, intermolecular Heck-type coupling of alkyl iodides and alkenes is described. This process is successful with a variety of primary and secondary unactivated alkyl iodides as reaction partners, including those with hydrogen atoms in the β position. The mild catalytic conditions enable intermolecular C-C bond formations with a diverse set of alkyl iodides and alkenes, including substrates containing base- or nucleophile-sensitive functionality.
Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (USA).
Caitlin M
CM
McMahon
Erik J
EJ
Alexanian
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D007454:Iodides / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000475:Alkenes; D007454:Iodides; D010165:Palladium
alkenes; alkyl halides; cross-coupling; homogeneous catalysis; palladium