Morphological and functional aspects of acute kidney injury after fetal programing in the offspring of diabetic rats.
OBJECTIVE
To evaluate the effects of folic acid (FA)-induced renal failure in young offspring of diabetic mothers.


METHODS
The offspring of streptozotocin-induced diabetic dams were divided into four groups: CC (controls receiving vehicle); DC (diabetics receiving vehicle); CA (controls receiving FA solution, 250 mg/kg) and DA (diabetics receiving FA solution, 250 mg/kg). Renal function tests and morphometry results were analyzed.


RESULTS
An increase in creatinine and urea levels was observed in CA and DA groups at two and five months. FA administration caused a significant reduction in the number of glomeruli in the offspring of diabetic dams. The diabetes group treated with FA had fewer glomeruli compared to controls at two and five months. FA caused an increase in the area of the urinary space both in controls and offspring of diabetic dams at two and five months. The number of glomeruli and area of the urinary space at two months were negatively correlated.


CONCLUSIONS
Fetal programing promotes remarkable changes in kidney morphology and function in offspring. We suggest that the morphological changes in the kidneys are more pronounced when fetal programing is associated with newly acquired diseases, e.g. renal failure induced by FA.
General Pathology Discipline .
Karla Roberta Martins
KR
Pucci
Carlos Donizete
CD
Pereira Júnior
Priscila Barbosa
PB
Idaló
Ana Carolina Santana Pinheiro
AC
Moreira
Laura Penna
LP
Rocha
Aldo Rogélis Aquiles
AR
Rodrigues
Luiz Carlos Dos
LC
Reis
Roseli A da Silva
RA
Gomes
Lenaldo Branco
LB
Rocha
Camila Souza de Oliveira
CS
Guimarães
Marlene Antônia Dos
MA
Reis
Niels Olsen Saraiva
NO
Câmara
Rosana Rosa Miranda
RR
Corrêa
D058186:Acute Kidney Injury / Q000196:embryology* / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D001794:Blood Pressure; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000196:embryology / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D006339:Heart Rate; D007668:Kidney / Q000503:physiopathology; D007677:Kidney Function Tests; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000473:pathology* / Q000503:physiopathology; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D013311:Streptozocin
Diabetes; folic acid-induced renal failure; kidney morphology; morphometry; pregnancy