Clot strength is negatively associated with ambulatory function in patients with peripheral artery disease and intermittent claudication.
Peripheral artery disease (PAD) is associated with exercise impairment and greater thrombotic risk. We investigated whether clot formation and platelet aggregation assessed by thromboelastography and light-transmission aggregometry correlate with the severity of symptomatic PAD assessed by ambulatory function measures. We studied 40 symptomatic patients with PAD in whom severity of disease was assessed using ankle-brachial index, peak walking time (PWT), claudication onset time, peak oxygen uptake, daily ambulatory activity, and walking impairment questionnaire (WIQ) scores. Clot strength correlated negatively with peak oxygen uptake, PWT, WIQ distance, and stair-climbing scores. Time to clot formation did not correlate with exercise parameters. Platelet aggregation was negatively correlated with WIQ distance score and was positively correlated with PWT and peak oxygen uptake. In conclusion, clot strength and platelet aggregation correlated with objective and self-perceived ambulatory measures. Patients with PAD having more severe walking impairment may be likely to form stronger clots.
Department of Geriatric Medicine, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
Karin
K
Mauer
Department of Geriatric Medicine, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
Andrew W
AW
Gardner
Department of Cardiology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
Tarun W
TW
Dasari
Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
Julie A
JA
Stoner
General Internal Medicine Section, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
Steve M
SM
Blevins
Department of Geriatric Medicine, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
Polly S
PS
Montgomery
Department of Cardiology, North Shore University Health System, Evanston, IL, USA.
Jorge F
JF
Saucedo
Department of Cardiology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA jose-exaire@ouhsc.edu.
J Emilio
JE
Exaire
D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D001777:Blood Coagulation; D003430:Cross-Sectional Studies; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D009825:Oklahoma; D010101:Oxygen Consumption; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D010974:Platelet Aggregation; D010979:Platelet Function Tests; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013997:Time Factors; D016138:Walking
ambulatory function; clot strength; peripheral artery disease