Hallway gossip between Ras and PI3K pathways.
In this issue of Blood, Goodwin et al investigate the pathogenesis of juvenile myelomonocytic leukemia (JMML), demonstrating that mutant Shp2 induces granulocyte macrophage-colony-stimulating factor (GM-CSF) hypersensitivity and that the p110δ subunit of phosphatidylinositol 3-kinase (PI3K) further promotes this dysregulation
UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES.
Peter D
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Emanuel
D000818:Animals; D058543:Class Ia Phosphatidylinositol 3-Kinase / Q000378:metabolism*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D054429:Leukemia, Myelomonocytic, Juvenile / Q000378:metabolism*; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000378:metabolism*
D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D058543:Class Ia Phosphatidylinositol 3-Kinase; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11