Mutant PTEN in Cancer: Worse Than Nothing.
Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.
Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh EH14 4AS, UK. Electronic address: n.r.leslie@hw.ac.uk.
Nick R
NR
Leslie
Hubrecht Institute-Koninklijke Nederlandse Akademie van Wetenschappen and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands; Institute of Biology Leiden, 2333 BE Leiden, the Netherlands.
Jeroen
J
den Hertog
D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D051059:PTEN Phosphohydrolase / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
D051059:PTEN Phosphohydrolase; C487757:Pten protein, mouse