Gender differences in the effect of adult amphetamine on cognitive functions of rats prenatally exposed to methamphetamine.
Psychostimulants have been shown to affect brain regions involved in the process of learning and memory consolidation. It has been shown that females are more sensitive to the effects of drugs than males. The aim of our study was to investigate how prenatal methamphetamine (MA) exposure and application of amphetamine (AMP) in adulthood would affect spatial learning of adult female and male rats. Mothers of the tested offspring were exposed to injections of MA (5mg/kg) or saline (SA) throughout the entire gestation period. Cognitive functions of adult rats were evaluated in the Morris Water Maze (MWM) tests. Adult offspring were injected daily with AMP (5mg/kg) or SA through the period of MWM testing. Our data from the MWM tests demonstrates the following. Prenatal MA exposure did not change the learning ability of adult male and female rats. However, AMP administration to adult animals affected cognitive function in terms of exacerbation of spatial learning (increasing the latency to reach the hidden platform, the distance traveled and the search error) only in female subjects. There were sex differences in the speed of swimming. Prenatal MA exposure and adult AMP treatment increased the speed of swimming in female groups greater than in males. Overall, the male subjects showed a better learning ability than females. Thus, our results indicate that the adult AMP treatment affects the cognitive function and behavior of rats in a sex-specific manner, regardless of prenatal exposure.
Charles University in Prague, Third Faculty of Medicine, Department of Normal, Pathological and Clinical Physiology, Prague, Czech Republic.
E
E
Macúchová
Charles University in Prague, Third Faculty of Medicine, Department of Normal, Pathological and Clinical Physiology, Prague, Czech Republic.
K
K
Nohejlová
Charles University in Prague, Third Faculty of Medicine, Department of Normal, Pathological and Clinical Physiology, Prague, Czech Republic. Electronic address: romana.slamberova@lf3.cuni.cz.
R
R
Slamberová
D000367:Age Factors; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000633:toxicity*; D003071:Cognition / Q000187:drug effects*; D005260:Female; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008694:Methamphetamine / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000523:psychology*; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D013037:Spatial Behavior / Q000187:drug effects
D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D000661:Amphetamine
Amphetamine; Estrous cycle; Memory; Methamphetamine; Morris Water Maze; Spatial learning