Salivary mucoepidermoid carcinoma revisited.
Clinicopathological features, prognosis and therapeutic strategies for mucoepidermoid carcinoma originating in salivary and salivary-type glands of the head and neck are reviewed. We emphasise histopathological aspects, appraise the value of histochemistry, electron microscopy, immunohistochemistry and cytophotometry, and discuss histogenesis and characteristic gene translocations. We additionally consider possible diagnostic difficulties, problems related to histological grading and accuracy of existing literature, and areas of controversy or uncertainty which may benefit from further investigations.
Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Andrés
A
Coca-Pelaz
Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.|Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain.
Juan P
JP
Rodrigo
Oral Pathology, School of Dentistry, University of Liverpool, Liverpool, UK.
Asterios
A
Triantafyllou
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Jennifer L
JL
Hunt
University of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy.
Alessandra
A
Rinaldo
Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
Primož
P
Strojan
Division of Oncology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Missak
M
Haigentz
Department of Radiation Oncology, University of Florida, Gainesville, FL, USA.
William M
WM
Mendenhall
Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Robert P
RP
Takes
Department of Otorhinolaryngology-Head and Neck Surgery, Leuven Cancer Institute, University Hospitals Leuven - KULeuven, Leuven, Belgium.
Vincent
V
Vander Poorten
University of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy. a.ferlito@uniud.it.
Alfio
A
Ferlito
D044963:Biopsy, Fine-Needle; D018277:Carcinoma, Mucoepidermoid / Q000235:genetics / Q000473:pathology / Q000628:therapy; D019468:Disease Management; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy