EPR imaging of dose distributions aiming at applications in radiation therapy.
A one-dimensional electron paramagnetic resonance (EPR) imaging method for visualisation of dose distributions in photon fields has been developed. Pressed pellets of potassium dithionate were homogeneously irradiated in a (60)Co radiation field to 600 Gy. The EPR analysis was performed with an X-Band (9.6 GHz) Bruker E540 EPR and EPR imaging spectrometer equipped with an E540 GC2X two-axis X-band gradient coil set with gradients along the y axis (along the sample tube) and z axis (along B0) and an ER 4108TMHS resonator. Image reconstruction, including deconvolution, baseline corrections and corrections for the resonator sensitivity, was performed using an in-house-developed Matlab code for the purpose to have a transparent and complete algorithm for image reconstruction. With this method, it is possible to visualise a dose distribution with an accuracy of ∼5 % within ±5 mm from the centre of the resonator.
Radiation Physics, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden eva.lund@liu.se.
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E
Lund
Department of Radiation Physics, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
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E
Adolfsson
Radiation Physics, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
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N
Kolbun
Department of Medical Technology (MTÖ), and Radiation Physics, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden Center for Medical Image Science and Visualization, CMIV, Linköping University, Linköping, Sweden.
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Gustafsson
D001918:Brachytherapy; D003037:Cobalt Radioisotopes; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D013871:Thiones / Q000737:chemistry / Q000528:radiation effects*
D003037:Cobalt Radioisotopes; D013871:Thiones