Impact of body composition on estimated glomerular filtration rate in relatively healthy adults in Taiwan.
OBJECTIVE
Chronic kidney diseases are associated with changes in cardiometabolic risk (CMR) factors in which body composition parameters have been used as sensitive predictors. This study aimed to explore the associations of anthropometric indicators, body fat (BF), body mass index (BMI) and waist circumference (WC) with estimated glomerular filtration rate (eGFR) in an adult healthy Chinese population.


METHODS
A cross-sectional study was conducted for the subjects undergoing annual health examinations. The associations of subjects with body composition parameters were analyzed using the cutoff values of BMI, BF and WC in accordance with the criteria for Asian or Taiwanese population by gender.


RESULTS
A total of 3473 subjects, aged 30-45 years, who received physical examinations in 2007 were analyzed. The levels of CMR factors were significantly higher in males than in females. eGFR was negatively associated with BMI but positively related to BF. The additional roles of BMI and WC were observed in the subjects who were categorized according to BF. Females with normal weight obese were associated with increased eGFR, whereas a higher eGFR was found in males with low/normal BF and BMI or normal WC.


CONCLUSIONS
Our data provided evidence that anthropometric parameters were associated with changes of eGFR in relatively healthy adults. Higher eGFR was observed in females with normal weight obese in whom hyperfiltration may be suspected, and this finding deserves further studies.
Department of Family Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.
Y-W
YW
Tsai
Department of Family Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.
C-I
CI
Ho
Department of Family Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.
J-Y
JY
Chen
Department of Family Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.
K-C
KC
Chang
Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.
Y-M
YM
Weng
Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.
S-Y
SY
Chen
Department of Occupation Medicine, Chang-Gung Memorial Hospital, Chiayi, Taiwan.
W-C
WC
Li
D000328:Adult; D001823:Body Composition / Q000502:physiology*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006331:Heart Diseases; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008659:Metabolic Diseases; D008875:Middle Aged; D010808:Physical Examination; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking; D013624:Taiwan; D055105:Waist Circumference
D008055:Lipids