'Lnc'-ing enhancers to MYC regulation.
Long noncoding RNAs (lncRNAs) are emerging as important functional components in the establishment of long-range chromosomal interactions. In a recent paper published in Cell Research, Xiang et al. provide mechanistic insight into this phenomenon by characterizing the role of CCAT1-L, a colorectal cancer-specific lncRNA, in intra-chromosome looping between the MYC gene promoter and distal upstream enhancer elements that regulate MYC transcription.
1] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA [2] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Scott T
ST
Younger
1] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA [2] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA [3] Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
John L
JL
Rinn
D002843:Chromatin / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*
D002843:Chromatin; D016271:Proto-Oncogene Proteins c-myc; D062085:RNA, Long Noncoding