Validity of the International Classification of Diseases, 10th revision discharge diagnosis codes for hyponatraemia in the Danish National Registry of Patients.
OBJECTIVE
To examine the validity of the International Classification of Diseases, 10th revision (ICD-10) codes for hyponatraemia in the nationwide population-based Danish National Registry of Patients (DNRP) among inpatients of all ages.


METHODS
Population-based validation study.


METHODS
All somatic hospitals in the North and Central Denmark Regions from 2006 through 2011.


METHODS
Patients of all ages admitted to hospital (n=819 701 individual patients) during the study period. The patient could be included in the study more than once, and our study did not restrict to patients with serum sodium measurements (total of n=2 186 642 hospitalisations).


METHODS
We validated ICD-10 discharge diagnoses of hyponatraemia recorded in the DNRP, using serum sodium measurements obtained from the laboratory information systems (LABKA) research database as the gold standard. One sodium value <135 mmol/L measured at any time during hospitalisation confirmed the diagnosis. We estimated sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for ICD-10 codes for hyponatraemia overall and for cut-off points for increasing hyponatraemia severity.


RESULTS
An ICD-10 code for hyponatraemia was recorded in the DNRP in 5850 of the 2 186 642 hospitalisations identified. According to laboratory measurements, however, hyponatraemia was present in 306 418 (14%) hospitalisations. Sensitivity of hyponatraemia diagnoses was 1.8% (95% CI 1.7% to 1.8%). For sodium values <115 mmol/L, sensitivity was 34.3% (95% CI 32.6% to 35.9%). The overall PPV was 92.5% (95% CI 91.8% to 93.1%) and decreased with increasing hyponatraemia severity. Specificity and NPV were high for all cut-off points (≥99.8% and ≥86.2%, respectively). Patients with hyponatraemia without a corresponding ICD-10 discharge diagnosis were younger and had higher Charlson Comorbidity Index scores than patients with hyponatraemia with a hyponatraemia code in the DNRP.


CONCLUSIONS
ICD-10 codes for hyponatraemia in the DNRP have high specificity but very low sensitivity. Laboratory test results, not discharge diagnoses, should be used to ascertain hyponatraemia.
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Louise
L
Holland-Bill
Christian Fynbo
CF
Christiansen
Sinna Pilgaard
SP
Ulrichsen
Troels
T
Ring
Jens Otto Lunde
JO
Jørgensen
Henrik Toft
HT
Sørensen
D000368:Aged; D000369:Aged, 80 and over; D003718:Denmark; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis*; D038801:International Classification of Diseases; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge; D011237:Predictive Value of Tests; D012015:Reference Standards; D012042:Registries; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012964:Sodium / Q000097:blood
D012964:Sodium
Epidemiology; Statistics & Research Methods