A case-control review of placentas from patients with intrahepatic cholestasis of pregnancy.
OBJECTIVE
To compare the incidence of histopathological features in placentas from women with cholestasis of pregnancy to healthy individuals without ICP.


METHODS
Placentas from mothers with and without cholestasis of pregnancy were reviewed by a pathologist masked to the study group. Subjects were excluded if they had medical problems already associated with placental histopathology.


RESULTS
Twenty-four cases and 30 controls placentas were reviewed. Seventeen placental histopathological features were found. There was no statistically significant difference between the groups. Amongst patients with cholestasis, there was a decrease in villitis of unknown etiology in those treated with ursodeoxycholic acid.


CONCLUSIONS
There is no difference in the placental histopathology in cholestasis of pregnancy compared to normal pregnancies, but treatment of patients with cholestasis of pregnancy with ursodeoxycholic acid may decrease findings of villitis of unknown etiology.
1Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA.
Shivani
S
Patel
Meaghan
M
Pinheiro
Juan C
JC
Felix
Neisha
N
Opper
Joseph G
JG
Ouzounian
Richard H
RH
Lee
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D016022:Case-Control Studies; D002780:Cholestasis, Intrahepatic / Q000188:drug therapy / Q000473:pathology*; D002824:Chorionic Villi / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010920:Placenta / Q000187:drug effects / Q000473:pathology*; D010922:Placenta Diseases / Q000473:pathology / Q000517:prevention & control; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000473:pathology*; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use; D055815:Young Adult
D000893:Anti-Inflammatory Agents; D014580:Ursodeoxycholic Acid
cholestasis; intrahepatic; placenta; pregnancy; ursodeoxycholic acid