A reagent-free oxidative cyclization approach to indolizine derivatives from α-picoline derivatives and nitroolefins.
A reagent-free oxidative cyclization between α-picoline derivatives and nitroolefins has been developed. This approach, in which the nitro group acts as an internal oxidant, provides an extremely simple, efficient, and atom-economic way to construct heteroaromatic indolizine derivatives.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (P. R. China), Fax: (+86) 27-68754672.
Meng
M
Gao
Jun
J
Tian
Aiwen
A
Lei
D000475:Alkenes / Q000737:chemistry*; D003500:Cyclization; D007202:Indicators and Reagents / Q000737:chemistry; D007212:Indolizines / Q000737:chemistry*; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D010847:Picolines / Q000737:chemistry*
D000475:Alkenes; D007202:Indicators and Reagents; D007212:Indolizines; D010847:Picolines; C035094:indolizine
green chemistry; indolizines; nitroolefins; oxidative cyclization; reagent-free; synthetic methods