Biological activities of new monohydroxylated brassinosteroid analogues with a carboxylic group in the side chain.
Thirteen monohydroxylated brassinosteroids analogues were synthesized and tested for their biological activity in plant and animal systems. The cytotoxic activity of the products was studied using human normal and cancer cell lines with 28-homocastasterone as positive control, their brassinolide type activity was established using the bean second-internode test with 24-epibrassinolide as standard.
Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 11, 78371 Olomouc, Czech Republic.
Miroslav
M
Kvasnica
Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 11, 78371 Olomouc, Czech Republic. Electronic address: jana.oklestkova@upol.cz.
Jana
J
Oklestkova
Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 11, 78371 Olomouc, Czech Republic; Department of Physical Chemistry, Faculty of Science, Palacký University, tř. 17. Listopadu 12, 77146 Olomouc, Czech Republic.
Vaclav
V
Bazgier
Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 11, 78371 Olomouc, Czech Republic.
Lucie
L
Rarova
Regional Centre of Advanced Technologies and Material, Department of Physical Chemistry, Faculty of Science, Palacký University, 17. Listopadu 12, 77146 Olomouc, Czech Republic.
Karel
K
Berka
Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 11, 78371 Olomouc, Czech Republic.
Miroslav
M
Strnad
D060406:Brassinosteroids / Q000008:administration & dosage / Q000138:chemical synthesis*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002777:Cholestanols / Q000008:administration & dosage / Q000138:chemical synthesis*; D003603:Cytotoxins / Q000008:administration & dosage / Q000138:chemical synthesis*; D006801:Humans; D015394:Molecular Structure; D013260:Steroids, Heterocyclic / Q000008:administration & dosage; D013329:Structure-Activity Relationship
D060406:Brassinosteroids; D002777:Cholestanols; D003603:Cytotoxins; D013260:Steroids, Heterocyclic; C023623:brassinolide
Anticancer activity; Brassinosteroids; Molecular docking; Organic synthesis; Plant bioassays; Receptor kinase BRI1