Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome.
With the advancement of transcriptome profiling by micro-arrays and high-throughput RNA-sequencing, transcriptome complexity and its dynamics are revealed at different levels in cardiovascular development and diseases. In this review, we will highlight the recent progress in our knowledge of cardiovascular transcriptome complexity contributed by RNA splicing, RNA editing and noncoding RNAs. The emerging importance of many of these previously under-explored aspects of gene regulation in cardiovascular development and pathology will be discussed.
Departments of Anesthesiology, Physiology and Medicine, Molecular Biology Institute, David Geffen School of Medicine at University of California at Los Angeles.
Chen
C
Gao
Yibin
Y
Wang
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology*; D006331:Heart Diseases / Q000196:embryology*; D006801:Humans; D017393:RNA Editing; D012326:RNA Splicing; D022661:RNA, Untranslated / Q000378:metabolism*; D059467:Transcriptome
D022661:RNA, Untranslated