[Relationship between metabolic diseases and all-cause and cardiovascular disease death in elderly male diabetics during a 10-year follow-up].
OBJECTIVE
To explore the relationship between metabolic diseases and death from all causes and cardiovascular diseases (CVD) in elderly male diabetics.


METHODS
A total of 681 elderly male diabetics were recruited from June 1997 to June 1999 and followed up for 10 years. All underwent regular check-ups in PLA General Hospital each year. The Cox proportional hazards model was applied to the multivariate survival analysis for all-cause and CVD mortality. And the cumulative survival rates were calculated by Kaplan-Meier method and log-rank test was used to compare the survival rates.


RESULTS
During a 10-year follow-up, 208 subjects died, including 70 deaths from CVD. Multivariate Cox regression analysis showed that age [relative risk (RR) = 1.099, 95% confidence interval (CI)1.076-1.123], pulse pressure (RR = 1.009, 95%CI 1.001-1.017) , elevated postprandial glucose level (RR = 1.115, 95%CI 1.075-1.157) and lower triglyceride (RR = 0.683, 95%CI 0.539-0.865) and high-density lipoprotein cholesterol (RR = 0.444, 95%CI 0.257-0.766) increased the risks of all-cause mortality while age (RR = 1.112, 95%CI 1.070-1.155) , elevated postprandial glucose level (RR = 1.278, 95%CI 1.170-1.396) and systolic blood pressure (RR = 1.013, 95%CI 1.002-1.024) increased the risks of CVD mortality. The cumulative survival rates from CVD mortality in diabetics with metabolic syndrome were significantly lower compared with those with diabetes only (P < 0.01) .


CONCLUSIONS
CVD remains a main cause of death for Chinese elderly male diabetics. Advanced age and elevated postprandial glucose level are risk factors of all-cause and CVD mortality. Diabetes mellitus with concurrent hypertension or metabolic syndrome is associated with an increased risk of CVD death.
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Banruo
B
Sun
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Xiaoling
X
Cheng
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Lichao
L
Ma
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China. Email: tianhui@medmail.com.
Hui
H
Tian
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Chunlin
C
Li
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000401:mortality*; D002423:Cause of Death; D002681:China / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000401:mortality*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000401:mortality; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000401:mortality; D012307:Risk Factors
D001786:Blood Glucose