Olfactory delayed matching to sample performance in mice: sex differences in the 5XFAD mouse model of Alzheimer's disease.
While olfactory delayed matching-to-sample tasks have been used to assess working memory in rats, no such tasks have been tested in mice. Olfactory delayed matching-to-sample learning was assessed in male and female 5XFAD mice, a model of Alzheimer's disease, and their wildtype (B6SJL F1) littermates at 6-7 months of age using an operant olfactometer. All 5XFAD and wildtype mice were able to learn the delayed olfactory matching-to-sample task at 2 and 5s delays. Fewer mice learned with a 10s delay and only one mouse learned with a 30s delay. Female mice showed higher levels of performance on the delayed matching-to-sample task than males, indicative of better working memory. These results demonstrate for the first time that mice are able to learn an olfactory delayed matching to sample task.
Department of Psychology and Neuroscience, Dalhousie University, P.O. Box 15000, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: kyle.roddick@dal.ca.
Kyle M
KM
Roddick
Department of Psychology and Neuroscience, Dalhousie University, P.O. Box 15000, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: heathers@dal.ca.
Heather M
HM
Schellinck
Department of Psychology and Neuroscience, Dalhousie University, P.O. Box 15000, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: rebrown@dal.ca.
Richard E
RE
Brown
D000544:Alzheimer Disease / Q000523:psychology*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D008570:Memory, Short-Term; D051379:Mice; D008822:Mice, Transgenic; D009483:Neuropsychological Tests; D009812:Odorants; D009833:Olfactory Pathways; D055696:Olfactory Perception; D012737:Sex Factors
5XFAD; Alzheimer's disease; Delayed matching-to-sample; Olfaction; Sex difference; Working memory