Co-encapsulation of resveratrol and curcumin in lipid-core nanocapsules improves their in vitro antioxidant effects.
Resveratrol and curcumin are natural antioxidants found in the human diet that have been used in the prevention and treatment of different diseases associated with oxidative stress. Aiming to improve the antioxidant effects of resveratrol and curcumin, lipid-core nanocapsules containing the combination of both polyphenols were developed. Physicochemical characteristics were evaluated and compared to the formulations containing each polyphenol individually. Co-encapsulation did not influence nanotechnological characteristics, and all formulations presented mean diameter around 200 nm, low polydispersity index, and encapsulation efficiency close to 100%. Nanoencapsulation increases the photostability of resveratrol and curcumin, and co-encapsulation improves resveratrol photostability. The in vitro antioxidant activity of polyphenols against HO radicals was enhanced by nanoencapsulation, and a better effect was observed after their co-nanoencapsulation. Also, nanocapsules exhibited controlled release profile, for both polyphenols. The results showed that the strategy to co-encapsulate resveratrol and curcumin is a promising approach to improve the performance of medicines used to prevent and treat diseases associated with oxidative stress.
Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
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Coradini
Departamento de Química, Universidade Federal de Santa Maria (UFSM), Santa Maria, Brazil.
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Lima
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
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Oliveira
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
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Chaves
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria (UFSM), Santa Maria, Brazil.
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ML
Athayde
Departamento de Química, Universidade Federal de Santa Maria (UFSM), Santa Maria, Brazil.
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LM
Carvalho
Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. Electronic address: ruy.beck@ufrgs.br.
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Beck
D000975:Antioxidants / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003474:Curcumin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D005609:Free Radicals; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007249:Inflammation; D008055:Lipids / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053769:Nanocapsules / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology; D018384:Oxidative Stress; D010316:Particle Size; D059808:Polyphenols / Q000737:chemistry; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage*
D000975:Antioxidants; D005609:Free Radicals; D008055:Lipids; D053769:Nanocapsules; D059808:Polyphenols; D013267:Stilbenes; D003474:Curcumin; D000077185:Resveratrol
Antioxidants; Curcumin; Lipid-core nanocapsules; Nanoparticles; Photostability; Resveratrol