Lewis acid/Brönsted acid mediated benz-annulation of thiophenes and electron-rich arenes.
A facile preparation of benz-annulated heterocycles were achieved at rt involving a Lewis acid/Brönsted acid mediated annulation of heterocycles using 2,5-dimethoxytetrahydrofuran as a four-carbon synthon. The benz-/naphth-annulation was found to be successful with electron-rich arenes as well.
Department of Organic Chemistry, School of Chemical Sciences, University of Madras , Guindy Campus, Chennai 600 025, Tamil Nadu, India.
Settu Muhamad
SM
Rafiq
Ramakrishnan
R
Sivasakthikumaran
Arasambattu K
AK
Mohanakrishnan