Effects of SCH-23390 and sulpiride on active avoidance in ovariectomized rats treated with a low dose of 17β-estradiol.
We studied the effects of dopamine D1/D2 receptor antagonists on the dynamics of acquisition and extinction of active avoidance responses and open field behavior in ovariectomized female rats. Dopamine D1 receptor antagonist SCH-23390 (0.1 mg/kg intraperitoneally) and dopamine D2 receptor antagonist sulpiride (10.0 mg/kg intraperitoneally) were administered chronically (14 days) either alone or in combination with a low dose of 17β-estradiol (0.5 μg per rat subcutaneously) to females after ovariectomy. It was found that SCH-23390 in combination with a low dose of 17β-estradiol completely restored impaired conditioning and retention of a conditioned avoidance response in ovariectomized animals. Simultaneous correction of behavioral patterns in the open field test was also observed in ovariectomized females receiving SCH-23390. Sulpiride injected alone or in combination with low dose of 17β-estradiol did not correct conditioning and reproduction of active avoidance response in females with estrogen deficiency and did not significantly affect animal behavior. The results indicate positive effect of dopamine D1 receptor blockade on active learning under conditions of estrogen deficiency.
Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia, julia.fedotova@mail.ru.
Yu O
YO
Fedotova
N S
NS
Sapronov
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001552:Benzazepines / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004958:Estradiol / Q000008:administration & dosage*; D004967:Estrogens / Q000172:deficiency; D005260:Female; D009043:Motor Activity / Q000187:drug effects; D010052:Ovariectomy; D017208:Rats, Wistar; D013469:Sulpiride / Q000494:pharmacology*
D001552:Benzazepines; D018492:Dopamine Antagonists; D004967:Estrogens; C534628:SCH 23390; D004958:Estradiol; D013469:Sulpiride