Two trypanocidal dipeptides from the roots of Zapoteca portoricensis (Fabaceae).
Zapoteca portoricensis (Jacq) HM Hernández is used with remarkable efficacy in ethnomedicinal management of tonsillitis in the Eastern part of Nigeria. Previous pharmacological studies have validated the antiinflammatory and antimicrobial activities of the crude extract. In this study, two dipeptides, saropeptate (aurantiamide acetate) and anabellamide, were isolated from the methanol root extract of Zapoteca portoricensis and their chemical structures deduced by one dimensional and two dimensional NMR and mass spectrometry. These compounds were isolated for the first time from this plant, and no report has been found on their previous isolation from the genus Zapoteca. Evaluation of their trypanocidal activity showed that compound 1 exhibited potent activity against Trypanosoma brucei rhodesiense with an IC50 value of 3.63 μM and selectivity index of 25.3.
Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, 410001 Nsukka, Enugu State, Nigeria. nwodong@hotmail.com.
Ngozi Justina
NJ
Nwodo
Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, 420281 Awka, Anambra State, Nigeria. basdenc@yahoo.com.
Festus Basden C
FB
Okoye
Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, D-40225 Dusseldorf, Germany. Laidaowan123@gmail.com.
Daowan
D
Lai
Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, D-40225 Dusseldorf, Germany. abdessamad.debbab@uni-dusseldorf.de.
Abdessamad
A
Debbab
Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Insitute, CH-4002 Basel, Switzerland. reto.brun@unibas.ch.
Reto
R
Brun
Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, D-40225 Dusseldorf, Germany. Proksch@uni-dusseldorf.de.
Peter
P
Proksch
D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification*; D007887:Fabaceae / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D014069:Tonsillitis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects*
D004151:Dipeptides; D010936:Plant Extracts; D014344:Trypanocidal Agents