Association between glycemic indices and beta cell function in patients with newly diagnosed type 2 diabetes.
OBJECTIVE
To identify the relationship between glycemic indices and β cell function in patients with newly diagnosed type 2 diabetes.


METHODS
The cross-sectional analysis included 61 patients with newly diagnosed type 2 diabetes who received continuous glucose monitoring (CGM) for 72 hours. The association between β cell function and glycemic indices including A1C and glycemic variability was investigated.


RESULTS
A1C (r = -0.405, p = 0.001) and standard deviation of blood glucose (SDBG, r = -0.274, p = 0.032) were significantly correlated to HOMA-β cell function (HBCI), whereas mean amplitude of glycemic excursions (MAGE, r = -0.210, p = 0.104) was not informative. After multiple confounders adjustments, A1C (β = -7.35, p < 0.001), MAGE (β = -4.64, p = 0.040), and SDBG (β = -12.3, p = 0.012) were associated with HBCI.


CONCLUSIONS
A1C and glycemic variability were both associated with β cell function in patients with newly diagnosed type 2 diabetes. The main limitations of the present study are the cross-sectional design in nature and the limited sample size.
Department of Geriatric Endocrinology, Chinese PLA General Hospital , Beijing , China.
Fu Sheng
FS
Fang
Xiao Ling
XL
Cheng
Yan Ping
YP
Gong
Liang Chen
LC
Wang
Lin
L
Li
Jian
J
Li
Hui
H
Tian
Chun Lin
CL
Li
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
Glycated hemoglobin; Glycemic variability; Type 2 diabetes