Advancing our understanding of the glucose system via modeling: a perspective.
The glucose story begins with Claude Bernard's discovery of glycogen and milieu interieur, continued with Banting's and Best's discovery of insulin and with Rudolf Schoenheimer's paradigm of dynamic body constituents. Tracers and compartmental models allowed moving to the first quantitative pictures of the system and stimulated important developments in terms of modeling methodology. Three classes of multiscale models, models to measure, models to simulate, and models to control the glucose system, are reviewed in their historical development with an eye to the future.
Claudio
C
Cobelli
Chiara Dalla
CD
Man
Morten Gram
MG
Pedersen
Alessandra
A
Bertoldo
Gianna
G
Toffolo
D035843:Biomedical Research / Q000266:history; D001786:Blood Glucose / Q000378:metabolism / Q000502:physiology; D003198:Computer Simulation; D003920:Diabetes Mellitus / Q000378:metabolism / Q000503:physiopathology; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D009928:Organ Specificity; D019397:Pancreas, Artificial
D001786:Blood Glucose; D007328:Insulin