Predicted configurations of oligosaccharide extensions in the lipooligosaccharide of nontypeable Haemophilus influenzae isolates.
Lipooligosaccharide configurations were predicted in nontypeable Haemophilus influenzae isolates based on the presence of seven oligosaccharide extension-initiating genes (or alleles). Predicted configurations with 2 to 3 oligosaccharide extensions were more prevalent among middle ear than throat strains. In addition, strains with these configurations averaged higher levels of serum resistance than strains with other configurations.
Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, USA.
Kirk W
KW
McCrea
Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, USA.
Jingping
J
Xie
Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, USA.
Deborah
D
Daniel
Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, USA.
Justin Theophilus
JT
Ulrich-Lewis
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA lxzhang@umich.edu.
Lixin
L
Zhang
D001770:Blood Bactericidal Activity; D002648:Child; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004432:Ear, Middle / Q000382:microbiology; D006192:Haemophilus Infections / Q000382:microbiology; D006193:Haemophilus influenzae / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D008070:Lipopolysaccharides / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D008969:Molecular Sequence Data; D010614:Pharynx / Q000382:microbiology; D017422:Sequence Analysis, DNA
D004269:DNA, Bacterial; D008070:Lipopolysaccharides