Synthesis of silver nanoparticles from Melia dubia leaf extract and their in vitro anticancer activity.
Silver nanoparticles have a significant role in the pharmaceutical science. Especially, silver nanoparticles synthesized by the plant extracts lead a significant role in biological activities such as antimicrobial, antioxidant and anticancer. Keeping this in mind, the present work investigation has been taken up with the synthesized silver nanoparticles using the plant extract of Melia dubia and it characterizes by using UV-visible, XRD and SEM-EDS. The effect of the silver nanoparticles on human breast cancer (KB) cell line has been tested. Silver nanoparticles showed remarkable cytotoxicity activity against KB cell line with evidence of high therapeutic index value are the results are discussed.
Department of Physics, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
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Kathiravan
Department of Engg. Physics, Annamalai University, Annamalainagar 608002, Tamil Nadu, India. Electronic address: ambedraviphy@gmail.com.
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Ravi
Department of Physics, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
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Ashokkumar
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor / Q000187:drug effects; D002470:Cell Survival; D002522:Chlorocebus aethiops; D005260:Female; D055772:Green Chemistry Technology; D006801:Humans; D061986:MCF-7 Cells; D031585:Melia / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013778:Tetrazolium Salts / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry; D014709:Vero Cells; D014961:X-Ray Diffraction
D000970:Antineoplastic Agents; D010936:Plant Extracts; D013778:Tetrazolium Salts; D013844:Thiazoles; D012834:Silver; C022616:thiazolyl blue
Anticancer activity; Melia dubia; Silver nanoparticle