Developing individualized coagulation profiling of disease risk: thrombin generation dynamic models of the pro and anticoagulant balance.
Global assays and computational models have advanced research into the realm of individualized profiling of hemostatic states. This brief review will describe one computational approach which utilizes an integrated method that evaluates the dynamics of thrombin generation by defining interactions of the pro and anticoagulant proteins, enzymes and cofactors based upon individualized concentrations of select factors. This plasma composition based computational modeling can provide a mechanism based bridge between empirical global assays of coagulation and individualized risk prediction.
University of Vermont, Department of Biochemistry, 208 South Park Drive, Colchester, Vermont 05446. Electronic address: Kathleen.brummel@uvm.edu.
Kathleen E
KE
Brummel-Ziedins
D000925:Anticoagulants / Q000494:pharmacology* / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001780:Blood Coagulation Tests; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D013917:Thrombin / Q000378:metabolism*
D000925:Anticoagulants; D001779:Blood Coagulation Factors; D013917:Thrombin