Does the metal content in soil around a pregnant woman's home increase the risk of low birth weight for her infant?
Low birth weight (LBW) is associated with a number of maternal environmental exposures during pregnancy. This study explored the association between soil metal concentrations around the home where the mother lived during pregnancy and the outcome of LBW. We used a retrospective cohort of 9,920 mother-child pairs who were insured by Medicaid during pregnancy and lived in ten residential areas, where we conducted soil sampling. We used a grid that overlaid the residential areas and collected soil samples at the grid intersections. The soil was analyzed for the concentration of eight metals [arsenic (As), barium (Ba), chromium (Cr), copper (Cu), lead (Pb), manganese (Mn), nickel (Ni), and mercury (Hg)], and we then used Bayesian Kriging to estimate the concentration at the actual maternal addresses, since we had the GIS coordinates of the homes. We used generalized additive modeling, because the metal concentrations had nonlinear associations with LBW, to develop the best fitting multivariable model for estimating the risk of LBW. The final model showed significant associations for female infants, maternal smoking during pregnancy, non-white mothers, Cu, and As with LBW. The As variable was nonlinear in relation to LBW, and the association between higher concentrations of As with LBW was strong (p = 0.002). We identified a statistically significant association between soil concentrations of arsenic around the home of pregnant women and an increased risk of LBW for her infant.
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Discovery 1, 915 Greene Street, Columbia, SC, 29208, USA, smcdermo@mailbox.sc.edu.
Suzanne
S
McDermott
Weichao
W
Bao
C Marjorie
CM
Aelion
Bo
B
Cai
Andrew B
AB
Lawson
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure; D058955:Metalloids / Q000032:analysis / Q000633:toxicity*; D008670:Metals / Q000032:analysis / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000453:epidemiology*; D012189:Retrospective Studies; D018570:Risk Assessment; D012989:Soil Pollutants / Q000032:analysis / Q000633:toxicity*; D013022:South Carolina / Q000453:epidemiology; D055815:Young Adult
D058955:Metalloids; D008670:Metals; D012989:Soil Pollutants