Directly thiolated modification onto the surface of detonation nanodiamonds.
An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds.
Nuclear Science & Technology Development Center and ‡Department of Chemistry, National Tsing Hua University , Hsinchu 30013, Taiwan.
Ming-Hua
MH
Hsu
Hong
H
Chuang
Fong-Yu
FY
Cheng
Ying-Pei
YP
Huang
Chien-Chung
CC
Han
Jiun-Yu
JY
Chen
Su-Chin
SC
Huang
Jen-Kun
JK
Chen
Dian-Syue
DS
Wu
Hsueh-Liang
HL
Chu
Chia-Ching
CC
Chang
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity; D046529:Microscopy, Electron, Transmission; D058612:Nanodiamonds / Q000737:chemistry* / Q000633:toxicity; D010316:Particle Size; D056951:Photoelectron Spectroscopy; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D058612:Nanodiamonds; D013438:Sulfhydryl Compounds; D006046:Gold