Influence of a two-year steroid treatment on body composition as measured by dual X-ray absorptiometry in boys with Duchenne muscular dystrophy.
Steroids are nowadays routinely used as a long-term treatment in Duchenne muscular dystrophy (DMD). Their effects on body composition were assessed using dual X-ray absorptiometry. The study followed over 2 years 29 genetically confirmed DMD patients: 21 in the steroid-treated group and 8 in the steroid-naïve group. After 2 years of steroid treatment, the lean tissue mass values increased significantly (p<0.0001), the percentage of body fat mass remained practically constant (p=0.94) in comparison with the initial visit. In the steroid-naïve patients, there were no significant increases in the lean tissue mass but deterioration in body composition confirmed by a significant increase in the percentage of body fat mass. Besides, significant negative correlations were found between the percentage of body fat mass and the MFM total score (R=-0.79, n=76, p<0.0001). A 2-year steroid treatment improves significantly body composition of boys with DMD through a significant increase in lean tissue mass. We suggest that a thorough check of body composition should be carried out before steroid treatment discontinuation in case of overweight gain.
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, L'Escale, Service de Médecine Physique et de Réadaptation Pédiatrique, Bron F-69500, France; Université de Lyon, Lyon F-69000, France; Université Lyon I, Villeurbanne F-69100, France; CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique Santé, Pierre-Bénite F-69310, France. Electronic address: carole.vuillerot@gmail.com.
Carole
C
Vuillerot
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, service d'imagerie et de radiologie pédiatrique, 69677 Bron Cedex, France.
Pierre
P
Braillon
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, L'Escale, Service de Médecine Physique et de Réadaptation Pédiatrique, Bron F-69500, France.
Stephanie
S
Fontaine-Carbonnel
Hospices Civils de Lyon, Pôle Information Médicale Évaluation Recherche, Lyon F-69003, France.
Pascal
P
Rippert
Centre Hospitalier d'Arles, Centre d'Action Médico-Sociale Précoce, Arles F-13637, France.
Elisabeth
E
André
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, L'Escale, Service de Médecine Physique et de Réadaptation Pédiatrique, Bron F-69500, France; Université de Lyon, Lyon F-69000, France; Université Lyon I, Villeurbanne F-69100, France; Hospices Civils de Lyon, Service de Biostatistique, Lyon F-69003, France.
Jean
J
Iwaz
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, L'Escale, Service de Médecine Physique et de Réadaptation Pédiatrique, Bron F-69500, France.
Isabelle
I
Poirot
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, L'Escale, Service de Médecine Physique et de Réadaptation Pédiatrique, Bron F-69500, France.
Carole
C
Bérard
D015502:Absorptiometry, Photon; D000293:Adolescent; D001823:Body Composition / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D020388:Muscular Dystrophy, Duchenne / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013256:Steroids / Q000008:administration & dosage / Q000627:therapeutic use*
D013256:Steroids
Body composition; Duchenne muscular dystrophy; Steroids