Apoptotic cell death under hypoxia.
Eukaryotic life depends largely on molecular oxygen. During evolution, ingenious mechanisms have evolved that allow organisms to adapt when oxygen levels decrease. Many of these adaptional responses to low oxygen are orchestrated by the heterodimeric transcription factor hypoxia-inducible factor (HIF). Here, we review the link between HIF and apoptosis.
Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Ataman
A
Sendoel
Michael O
MO
Hengartner
D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D016923:Cell Death / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology*; D010100:Oxygen / Q000378:metabolism
D051792:Basic Helix-Loop-Helix Proteins; D010100:Oxygen