Involvement of the long-chain fatty acid receptor GPR40 in depression-related behavior.
The functional role of brain G protein-coupled receptor 40 (GPR40) remains unclear. We investigated GPR40 signaling in depression-related behavior in mice via the forced swim test. A repeated but not a single intracerebroventricular administration of the GPR40 agonist, GW9508, reduced the duration of immobility behavior. Moreover, the levels of hippocampal non-esterified docosahexaenoic acid and arachidonic acid were decreased immediately after the forced swimming. These results suggested that brain GPR40 signaling may regulate depression-related behavior.
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Japan.
Takashi
T
Nishinaka
Takuya
T
Yamashita
Kazuo
K
Nakamoto
Fumiyo
F
Kasuya
Shogo
S
Tokuyama
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001522:Behavior, Animal; D003863:Depression / Q000235:genetics* / Q000378:metabolism / Q000523:psychology*; D004281:Docosahexaenoic Acids / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D046353:Immobility Response, Tonic / Q000187:drug effects; D008297:Male; D008744:Methylamines / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D011422:Propionates / Q000494:pharmacology; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology*; D013550:Swimming / Q000502:physiology / Q000523:psychology
C473036:Ffar1 protein, mouse; C515630:GW9508; D008744:Methylamines; D011422:Propionates; D043562:Receptors, G-Protein-Coupled; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid