STAT2 signaling and dengue virus infection.
Dengue virus (DENV) is an important human pathogen whose byzantine relationship with the immune response is poorly understood. DENV causes dengue fever and dengue hemorrhagic fever/dengue shock syndrome, diseases for which palliative care is the only treatment. DENV immunopathogenesis studies are complicated by the lack of an immunocompetent small-animal model, and this has hindered anti-DENV drug and vaccine development. This review describes strategies that DENV uses to evade the type I interferon response and focuses on how data gained from the study of DENV NS5-mediated STAT2 degradation may be used to create immunocompetent DENV mouse models and design anti-DENV therapeutics.
Department of Microbiology; University of Washington; Seattle, WA USA.
Juliet
J
Morrison
Department of Microbiology; Icahn School of Medicine at Mount Sinai; New York, NY USA ; Global Health and Emerging Pathogens Institute; Icahn School of Medicine at Mount Sinai; New York, NY USA ; Department of Medicine; Icahn School of Medicine at Mount Sinai; New York, NY USA.
Adolfo
A
García-Sastre
NS5; STAT2; antagonism; dengue virus; host tropism; interferon; mouse model