Actomyosin networks and tissue morphogenesis.
Tissue morphogenesis is driven by coordinated cellular deformations. Recent studies have shown that these changes in cell shape are powered by intracellular contractile networks comprising actin filaments, actin cross-linkers and myosin motors. The subcellular forces generated by such actomyosin networks are precisely regulated and are transmitted to the cell cortex of adjacent cells and to the extracellular environment by adhesive clusters comprising cadherins or integrins. Here, and in the accompanying poster, we provide an overview of the mechanics, principles and regulation of actomyosin-driven cellular tension driving tissue morphogenesis.
Institut de Biologie du Développement de Marseille, Aix-Marseille Université, CNRS UMR 7288, Campus de Luminy, 13009 Marseille, France.
Akankshi
A
Munjal
Thomas
T
Lecuit
D000199:Actins / Q000378:metabolism; D000205:Actomyosin / Q000378:metabolism*; D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism; D006801:Humans; D009024:Morphogenesis; D009928:Organ Specificity; D015398:Signal Transduction
D000199:Actins; D015815:Cell Adhesion Molecules; D000205:Actomyosin
Adhesion; Contractility; Mechanics; Morphogenesis; Myosin