Experimental and computational study on 2,2'-[(1E,2E)-hydrazine-1,2-diylidenedi(1E)eth-1-yl-1-ylidene]diphenol and its Ni(II), Pt(II), Pd(II) complexes.
2,2'-[(1E,2E)-hydrazine-1,2-diylidenedi(1E)eth-1-yl-1-ylidene]diphenol and its dimeric, binuclear Ni(II), Pd(II) and Pt(II) metal complexes were synthesized. Hydrazine derivative and its complexes were characterized by elemental analyses, LC-MS, IR, electronic spectra, (1)H and (13)C NMR spectra, conductivity and magnetic measurements. 1H and 13C shielding tensors for crystal structure were calculated with GIAO/DFT/B3LYP/6-311++G(d,p) methods in CDCl3. The vibrational band assignments were performed at B3LYP/6-311++G(d,p) theory level combined with scaled quantum mechanics force field (SQMFF) methodology. The antibacterial activities of synthesized compounds were studied against some Gram-positive and Gram-negative bacteria by using the microdilution and disk diffusion method. As the antibacterial activity results evidently show, the compound possessed a broad spectrum of activity against the tested bacteria.
Department of Chemistry, Science Faculty, Karatekin University, TR-18100 Çankırı, Turkey. Electronic address: saliha@karatekin.edu.tr.
Saliha
S
Alyar
Department of Primary Education, Faculty of Education, Ahi Evran University, 40100 Kırşehir, Turkey.
Neslihan
N
Özbek
College of Arts & Sciences, Department of Chemistry, Howard University, 525 College Street NW, Washington, DC 20059, USA; Department of Physics, Faculty of Sciences, Erciyes University, 38039 Kayseri, Turkey.
Sema Öztürk
SÖ
Yıldırım
Department of Physics Engineering, Faculty of Engineering, Hacettepe University, 06800 Beytepe, Ankara, Turkey.
Semra
S
Ide
College of Arts & Sciences, Department of Chemistry, Howard University, 525 College Street NW, Washington, DC 20059, USA.
Ray J
RJ
Butcher
D000890:Anti-Infective Agents / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002853:Chromatography, Liquid; D018360:Crystallography, X-Ray; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006834:Hydrazines / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry*; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014732:Vibration
D000890:Anti-Infective Agents; D006834:Hydrazines; D009944:Organoplatinum Compounds; D010636:Phenols; D010984:Platinum; D010165:Palladium; D002244:Carbon; D009532:Nickel; D006859:Hydrogen
Antibacterial activity; Complex; HOMO; Hydrazine; LUMO; X-ray