Pyoderma gangrenosum successfully treated with antiretroviral therapy alone in a human immunodeficiency virus-infected individual.
We report a case of a 60-year-old man infected with human immunodeficiency virus (HIV) who was transferred to our hospital for management of multiple non-healing, painful ulcers on the lower extremities. The histological findings of the biopsy specimen were compatible with the diagnosis of pyoderma gangrenosum (PG). An association between HIV infection and the development of PG was considered after a thorough investigation. Antiretroviral therapy without the use of adjunctive immunosuppressive agents resulted in clinical improvement. Our case implies that antiretroviral therapy alone could heal PG in untreated HIV-infected patients.
Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Japan; Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, Japan.
Naoya
N
Sakamoto
Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Japan. Electronic address: naokiy@cick.jp.
Naoki
N
Yanagisawa
Department of Clinical Laboratory, Tokyo Metropolitan Komagome Hospital, Japan.
Noritaka
N
Sekiya
Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Japan.
Akihiko
A
Suganuma
Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Japan.
Akifumi
A
Imamura
Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Japan.
Atsushi
A
Ajisawa
D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000150:complications / Q000175:diagnosis / Q000473:pathology
D044966:Anti-Retroviral Agents
Antiretroviral therapy; HIV infection; Pyoderma gangrenosum