Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases.
Abstract Renalase, a novel amine oxidase, is mainly expressed in the kidney, heart, and skeletal muscle. It has been known to degrade circulating catecholamines and plays a crucial role in human diseases. Recent studies have demonstrated its structure, unique bioactivities, function, and the gene polymorphisms in human diseases. In this review, we summarize the effects of renalase on hypertension, myocardial ischemia, acute kidney injury (AKI), ischemic stroke, cardiac dysfunction, organ transplantation, and diabetes mellitus reported in numerous studies.
Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China (mainland).
Xiaogang
X
Li
Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China (mainland).
Ruixia
R
Huang
Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China (mainland).
Zijian
Z
Xie
Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China (mainland).
Mingyuan
M
Lin
Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China (mainland).
Zhongshu
Z
Liang
Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China (mainland).
Yan
Y
Yang
Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China (mainland).
Weihong
W
Jiang
D003920:Diabetes Mellitus / Q000201:enzymology; D006334:Heart Function Tests; D016027:Heart Transplantation; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000503:physiopathology; D008995:Monoamine Oxidase / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000201:enzymology* / Q000503:physiopathology
D008995:Monoamine Oxidase; C521557:renalase