Phosphate esters and anhydrides--recent strategies targeting nature's favoured modifications.
Esters and anhydrides of phosphoric acid are essential in biology. It is very difficult to identify processes in life that do not involve these modifications and their transformation at some point. Consequently, phosphorylation chemistry is an essential methodology with significant impact on the biological sciences. This perspective gives an overview of some very recent achievements in synthetic phosphorylation chemistry and aims at identifying challenges that lie ahead.
University of Zürich, Department of Chemistry, Winterthurerstrasse 190, 8057 Zürich, Switzerland. henningjacob.jessen@chem.uzh.ch.
Henning J
HJ
Jessen
Nisar
N
Ahmed
Alexandre
A
Hofer
D000812:Anhydrides / Q000138:chemical synthesis / Q000737:chemistry*; D003848:Deoxyguanine Nucleotides / Q000138:chemical synthesis / Q000737:chemistry; D004952:Esters / Q000737:chemistry*; D010710:Phosphates / Q000138:chemical synthesis* / Q000737:chemistry; D014530:Uridine Diphosphate / Q000138:chemical synthesis / Q000737:chemistry; D014542:Uridine Monophosphate / Q000737:chemistry
D000812:Anhydrides; D003848:Deoxyguanine Nucleotides; D004952:Esters; D010710:Phosphates; D014530:Uridine Diphosphate; C029603:deoxyguanosine triphosphate; D014542:Uridine Monophosphate