Microwave assisted synthesis, spectral and antifungal studies of 2-phenyl-N,N'-bis(pyridin-4-ylcarbonyl)butanediamide ligand and its metal complexes.
2-Phenyl-N,N'-bis(pyridin-4-ylcarbonyl)butanediamide ligand with a series of transition metal complexes has been synthesized via two routes: microwave irradiation and conventional heating method. Microwave irritation method happened to be the efficient and versatile route for the synthesis of these metal complexes. These complexes were found to have the general composition M(L)Cl2/M(L)(CH3COO)2 (where M = Cu(II), Co(II), Ni(II), and L = ligand). Different physical and spectroscopic techniques were used to investigate the structural features of the synthesized compounds, which supported an octahedral geometry for these complexes. In vitro antifungal activity of the ligand and its metal complexes revealed that the metal complexes are highly active compared to the standard drug. Metal complexes showed enhanced activity compared to the ligand, which is an important step towards the designing of antifungal drug candidates.
Biomaterial Research Unit, School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150 Kelantan, Malaysia.
Rayees Ahmad
RA
Shiekh
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
Maqsood Ahmad
MA
Malik
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
Shaeel Ahmed
SA
Al-Thabaiti
Departamento de Quımica, FCTUC, Universidade de Coimbra, Rua Larga, 3004-535 Coimbra, Portugal.
Mohmmad Younus
0000-0002-1838-1337
MY
Wani
School of Pharmaceutical Sciences, Lovely Faculty of Applied Medical Sciences, Lovely Professional University, Punjab-144411, India.
Arshid
A
Nabi
D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D008024:Ligands; D019216:Metals, Heavy / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D015394:Molecular Structure
D000935:Antifungal Agents; D056831:Coordination Complexes; D008024:Ligands; D019216:Metals, Heavy