Cross-infection of solid organ transplant recipients by a multidrug-resistant Klebsiella pneumoniae isolate producing the OXA-48 carbapenemase, likely derived from a multiorgan donor.
We describe two cases of bacteremic infections caused by a multidrug-resistant Klebsiella pneumoniae isolate producing the OXA-48 carbapenemase that occurred in two solid organ transplant (liver and kidney) recipients, which was apparently transmitted with the allografts. This finding underscores the risk of donor-derived infections by multidrug-resistant Gram-negative pathogens in solid organ transplant recipients and emphasizes the need for rapid screening of organ donors for carriage of similar pathogens.
Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Tommaso
T
Giani
Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Viola
V
Conte
Department of Laboratory Medicine and Advanced Biotechnologies, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy UPMC, Palermo, Italy.
Salvatore
S
Mandalà
Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Marco Maria
MM
D'Andrea
Clinical Microbiology and Virology Unit, A. Manzoni Hospital, Lecco, Italy.
Francesco
F
Luzzaro
Department of Laboratory Medicine and Advanced Biotechnologies, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy RiMED foundation, Palermo, Italy.
Pier Giulio
PG
Conaldi
Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy Clinical Infectious Diseases Unit, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.
Paolo
P
Grossi
Department of Medical Biotechnologies, University of Siena, Siena, Italy Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy Clinical Microbiology and Virology Unit, Department of Laboratory Medicine, Careggi University Hospital, Florence, Italy gianmaria.rossolini@unifi.it.
Gian Maria
GM
Rossolini
D000328:Adult; D016470:Bacteremia / Q000175:diagnosis*; D003428:Cross Infection / Q000175:diagnosis*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007710:Klebsiella Infections / Q000175:diagnosis*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology* / Q000302:isolation & purification; D008875:Middle Aged; D066027:Transplant Recipients; D014180:Transplantation / Q000009:adverse effects; D019737:Transplants; D001618:beta-Lactamases / Q000378:metabolism*
D001618:beta-Lactamases; C108449:oxacillinase