Genome reactivation after the silence in mitosis: recapitulating mechanisms of development?
Transcription is silenced during mitosis and reactivated at mitotic exit. The dynamics and identities of "bookmarking" transcription factors and chromatin marks that mediate reactivation often recapitulate those observed during cell identity establishment in development. Thus, features of postmitotic gene reactivation can provide insights into mechanisms of developmental cell fate establishment.
Epigenetics Program, Institute of Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: zaret@upenn.edu.
Kenneth S
KS
Zaret
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D016678:Genome / Q000235:genetics*; D006801:Humans; D008938:Mitosis / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*
D014157:Transcription Factors