Electrospun chitosan/sericin composite nanofibers with antibacterial property as potential wound dressings.
Chitosan and sericin are natural and low cost biomaterials. Both biomaterials displayed good compatibility to human tissues and antibacterial properties for biomedical application. In this study, we have successfully fabricated chitosan/sericin composite nanofibers by electrospinning. The obtained composite nanofibers were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectrometer (FT-IR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA) studies. The composite nanofibers had good morphology with diameter between 240nm and 380nm. In vitro methyl thiazolyl tetrazolium (MTT) assays demonstrated that the chitosan/sericin composite nanofibers were biocompatible and could promote the cell proliferation. Furthermore, the composite nanofibers showed good bactericidal activity against both of Gram-positive and Gram-negative bacteria. Thus, the chitosan/sericin composite nanofibers are promising for wound dressing applications.
Alan G. MacDiarmid Institute, Jilin University, Changchun 130012, PR China.
Rui
R
Zhao
Alan G. MacDiarmid Institute, Jilin University, Changchun 130012, PR China; Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, PR China. Electronic address: xiangli@jlu.edu.cn.
Xiang
X
Li
Alan G. MacDiarmid Institute, Jilin University, Changchun 130012, PR China.
Bolun
B
Sun
Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, PR China.
Ying
Y
Zhang
Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, PR China.
Dawei
D
Zhang
Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, PR China.
Zhaohui
Z
Tang
Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, PR China.
Xuesi
X
Chen
Alan G. MacDiarmid Institute, Jilin University, Changchun 130012, PR China.
Ce
C
Wang
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D001458:Bandages; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003460:Crystallization; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D051379:Mice; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D047030:Sericins / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014947:Wounds and Injuries / Q000473:pathology*; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D047030:Sericins; D048271:Chitosan
Composite nanofibers; Electrospinning; Wound dressings