The protective effect of dietary Arthrospira (Spirulina) maxima against mutagenicity induced by benzo[alpha]pyrene in mice.
Benzo[alpha]pyrene (B[α]P) was used to test the possible antimutagenic effects of Arthrospira (Spirulina) maxima (SP) on male and female mice. SP was orally administered at 0, 200, 400, or 800 mg/kg of body weight to animals of both sexes for 2 weeks before starting the B[α]P (intraperitoneal injection) at 125 mg/kg of body weight for 5 consecutive days. For the male dominant lethal test, each male was caged with two untreated females per week for 3 weeks. For the female dominant lethal test, each female was caged for 1 week with one untreated male. All the females were evaluated 13-15 days after mating for incidence of pregnancy, total corpora lutea, total implants and pre- and postimplant losses. SP protected from B[α]P-induced pre- and postimplant losses in the male dominant lethal test, and from B[α]P-induced postimplantation losses in treated females. Moreover, SP treatment significantly reduced the detrimental effect of B[α]P on the quality of mouse semen. Our results illustrate the protective effects of SP in relation to B[α]P-induced genetic damage to germ cells. We conclude that SP, owing mainly to the presence of phycocyanin, could be of potential clinical interest in cancer treatment or prevention of relapse.
1 Department of Pharmacy, National School of Biological , Sciences, Adolfo López Mateos Professional Unit, Mexico City, Mexico .
Germán
G
Chamorro-Cevallos
Leticia
L
Garduño-Siciliano
Elizdath
E
Martínez-Galero
Angélica
A
Mojica-Villegas
Nicole
N
Pages
Gabriela
G
Gutiérrez-Salmeán
D000034:Abortion, Veterinary / Q000517:prevention & control; D000818:Animals; D016587:Antimutagenic Agents / Q000008:administration & dosage / Q000032:analysis*; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors*; D001947:Breeding; D004032:Diet; D019587:Dietary Supplements; D005260:Female; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D010063:Ovum / Q000187:drug effects; D010798:Phycocyanin / Q000008:administration & dosage; D011247:Pregnancy; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects; D053545:Spirulina
D016587:Antimutagenic Agents; D009153:Mutagens; D010798:Phycocyanin; D001564:Benzo(a)pyrene
anticancer; antigenotoxic; antioxidant; blue-green algae; cyanobacterium