Adoptive transfer method to study platelet function in mouse models of disease.
Platelets play an important role in many physiological and pathological situations. However, the molecular mechanisms by which platelets contribute to health and disease are often ill-defined. One of the limiting factors to these studies is a fast but reliable method to generate animals with platelet-specific signaling defects. We here review recent approaches to establish an adoptive platelet transfer model in mice.
Department of Biochemistry/Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: bergmeie@email.unc.edu.
Wolfgang
W
Bergmeier
McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yacine
Y
Boulaftali
D019264:Adoptive Transfer / Q000379:methods*; D000818:Animals; D001792:Blood Platelets / Q000276:immunology / Q000473:pathology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice / Q000235:genetics / Q000276:immunology; D013921:Thrombocytopenia / Q000139:chemically induced / Q000235:genetics / Q000276:immunology / Q000473:pathology*