Association of N-terminal pro-brain natriuretic peptide and hemodynamic parameters measured by impedance cardiography in patients with essential hypertension.
The aim of this study was to evaluate the association of NT-proBNP with clinical and hemodynamic assessment in 156 patients with arterial hypertension. NT-proBNP correlated positively with, i.e. age (r=0.310, p=0.00008), mean blood pressure (MBP; r=0.199, p=0.0136), Heather index (HI; r=0.375, p<0.00001) and negatively with thoracic fluid content (TFC; r=-0.300, p=0.0002). The patients with higher NT-proBNP were older (46.1 versus 40.6 years, p=0.001), with higher MBP (102.6 versus 98.5 mm Hg, p=0.0043), HI (14.54 versus 11.93 Ohm s2, p=0.009) and lower TFC (27.5 versus 29.4 1/kOhm, p=0.0032). The independent predictors of higher NT-proBNP were: age, MBP and HI.
Department of Cardiology and Internal Diseases, Military Institute of Medicine , Warsaw , Poland and.
Paweł
P
Krzesiński
Grzegorz
G
Gielerak
Adam
A
Stańczyk
Katarzyna
K
Piotrowicz
Wiesław
W
Piechota
Andrzej
A
Skrobowski
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002307:Cardiography, Impedance / Q000379:methods; D018450:Disease Progression; D004452:Echocardiography; D000075222:Essential Hypertension; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011498:Protein Precursors; D012189:Retrospective Studies; D012720:Severity of Illness Index
D015415:Biomarkers; D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
Amino-terminal pro-brain natriuretic peptide; cardiovascular system; hemodynamics; hypertension; impedance cardiography