Application of two-dimensional echocardiography combined with enhanced flow in diagnosing fetal heart malformation.
OBJECTIVE
The current study aims to evaluate the diagnostic accuracy of two-dimensional echocardiography combined with enhanced flow (e-flow) imaging for fetal heart malformation.


METHODS
A total of 1,639 pregnant women were enrolled. They were examined using fetal echocardiography combined e-flow. The obtained results were compared with those by postnatal examination or post-induction autopsy.


RESULTS
Complete data were obtained from 1,286 out of the 1,639 fetuses (78.46%). Two-dimensional echocardiography combined with e-flow imaging had sensitivity, specificity, a misdiagnosis rate, and a missed diagnosis rate of 98.0%, 99.3%, 2.0%, and 0.7%, respectively. It has a consistency evaluation Kappa value of 0.970 (p = 0.000).


CONCLUSIONS
Two-dimensional echocardiography combined with e-flow is an accurate and reliable diagnostic method for fetal heart malformation. It has high sensitivity and specificity.
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D000293:Adolescent; D000328:Adult; D003326:Coronary Circulation; D018618:Echocardiography, Doppler, Color / Q000379:methods; D005260:Female; D005318:Fetal Heart / Q000000981:diagnostic imaging* / Q000473:pathology; D006330:Heart Defects, Congenital / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D011247:Pregnancy; D011652:Pulmonary Circulation; D012680:Sensitivity and Specificity; D055815:Young Adult