Preliminary investigation on hemocompatibility of poly(vinylidene fluoride) membrane grafted with acryloylmorpholine via ATRP.
This work provides a promising way to improve the hemocompatibility of PVDF membrane. An amphiphilic copolymer (PVDF-g-PACMO) having PVDF backbones and poly(N-acryloylmorpholine) (PACMO) side chains was synthesized via atom transfer radical polymerization (ATRP). It is found that the grafting degree of the PACMO increases linearly with the increase of ACMO concentration in the reaction solution. The PVDF-g-PACMO membrane was prepared via immersed phase inversion method. The structure and performances were evaluated by X-ray photoelectron spectroscopy, field emission scanning electron microscopy, water contact angle, and filtration experiment. The hemocompatibility of the membranes were preliminarily investigated by protein adsorption, platelet adhesion, anticoagulant evaluation and hemolysis test. The results indicate that the PVDF membrane functionalized by PACMO can suppress the protein adsorption and platelet adhesion, and shows an improved hemocompatibility.
State Key Laboratory of Hollow Fiber Membrane Materials and Processes, School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin, China.
Xiang
X
Shen
Jie
J
Liu
Xia
X
Feng
Yiping
Y
Zhao
Li
L
Chen
D000178:Acrylamides / Q000737:chemistry*; D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D002417:Cattle; D006461:Hemolysis; D008422:Materials Testing; D008567:Membranes, Artificial; D009025:Morpholines / Q000737:chemistry*; D010973:Platelet Adhesiveness; D011145:Polyvinyls / Q000138:chemical synthesis* / Q000737:chemistry*; D005465:Fluorocarbon Polymers
D000178:Acrylamides; D008567:Membranes, Artificial; D009025:Morpholines; D011145:Polyvinyls; C527295:4-acryloylmorpholine; C024865:polyvinylidene fluoride; D005465:Fluorocarbon Polymers
ATRP; N-acryloylmorpholine; hemocompatibility; platelet adhesion; poly(vinylidene fluoride)