Usefulness of the murine model to study the immune response against Histoplasma capsulatum infection.
The present paper is an overview of the primary events that are associated with the histoplasmosis immune response in the murine model. Valuable data that have been recorded in the scientific literature have contributed to an improved understanding of the clinical course of this systemic mycosis, which is caused by the dimorphic fungus Histoplasma capsulatum. Data must be analyzed carefully, given that misinterpretation could be generated because most of the available information is based on experimental host-parasite interactions that used inappropriate proceedings, i.e., the non-natural route of infection with the parasitic and virulent fungal yeast-phase, which is not the usual infective phase of the etiological agent of this mycosis. Thus, due to their versatility, complexity, and similarities with humans, several murine models have played a fundamental role in exploring the host-parasite interaction during H. capsulatum infection.
Laboratorio de Inmunología de Hongos, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México, DF 04510, Mexico; Unidad de Micología Médica y Experimental, Corporación para Investigaciones Biológicas, Medellín, Colombia.
Jorge H
JH
Sahaza
Laboratorio de Filogenia del Sistema Inmune de Piel y Mucosas, Departamento de Biología Celular y Tisular, Facultad de Medicina, UNAM, México, DF 04510, Mexico.
Armando
A
Pérez-Torres
Laboratorio de Inmunología, Departamento de Bioquímica, Facultad de Medicina, UNAM, México, DF 04510, Mexico.
Edgar
E
Zenteno
Laboratorio de Inmunología de Hongos, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México, DF 04510, Mexico. Electronic address: emello@unam.mx.
Maria Lucia
ML
Taylor
D056704:Adaptive Immunity; D056809:Alveolar Epithelial Cells / Q000276:immunology / Q000382:microbiology; D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000382:microbiology; D002473:Cell Wall / Q000737:chemistry / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology / Q000382:microbiology; D004195:Disease Models, Animal; D006658:Histoplasma / Q000254:growth & development / Q000276:immunology* / Q000472:pathogenicity; D006660:Histoplasmosis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D058507:Host Specificity; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D013045:Species Specificity; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000382:microbiology
Adaptive response.; Histoplasma capsulatum; Histoplasmosis; Innate immunity; Murine model