Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of quinolin-3-amines.
A chiral phosphoric acid catalyzed asymmetric transfer hydrogenation of aromatic amines, quinolin-3-amines, was successfully developed with up to 99% ee. To supplement our previous work on the Ir-catalyzed asymmetric hydrogenation of 2-alkyl substituted quinolin-3-amines, a number of 2-aryl substituted substrates were reduced to provide a series of valuable chiral exocyclic amines with high diastereo- and enantioselectivities.
Department of Chemistry, Dalian University of Technology , Dalian 116012, P. R. China.
Xian-Feng
XF
Cai
Ran-Ning
RN
Guo
Guang-Shou
GS
Feng
Bo
B
Wu
Yong-Gui
YG
Zhou
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D000634:Aminoquinolines / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry*; D013237:Stereoisomerism
D000588:Amines; D000634:Aminoquinolines; D010756:Phosphoric Acids; C030242:phosphoric acid