Self-reported pain intensity with the numeric reporting scale in adult dengue.
BACKGROUND
Pain is a prominent feature of acute dengue as well as a clinical criterion in World Health Organization guidelines in diagnosing dengue. We conducted a prospective cohort study to compare levels of pain during acute dengue between different ethnicities and dengue severity.


METHODS
Demographic, clinical and laboratory data were collected. Data on self-reported pain was collected using the 11-point Numerical Rating Scale. Generalized structural equation models were built to predict progression to severe disease.


RESULTS
A total of 499 laboratory confirmed dengue patients were recruited in the Prospective Adult Dengue Study at Tan Tock Seng Hospital, Singapore. We found no statistically significant differences between pain score with age, gender, ethnicity or the presence of co-morbidity. Pain score was not predictive of dengue severity but highly correlated to patients' day of illness. Prevalence of abdominal pain in our cohort was 19%. There was no difference in abdominal pain score between grades of dengue severity.


CONCLUSIONS
Dengue is a painful disease. Patients suffer more pain at the earlier phase of illness. However, pain score cannot be used to predict a patient's progression to severe disease.
Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore.
Joshua G X
JG
Wong
Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore.
Victor C
VC
Gan
Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore.
Ee-Ling
EL
Ng
Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technologicial University, Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Yee-Sin
YS
Leo
Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore; Stata Users Group, Singapore, Singapore; Department of Mathematics and Science, La Trobe University, Melbourne, Victoria, Australia.
Siew-Pang
SP
Chan
Stata Users Group, Singapore, Singapore; Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Singapore, Singapore.
Robin
R
Choo
Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
David C
DC
Lye
D015746:Abdominal Pain / Q000453:epidemiology* / Q000208:ethnology; D000328:Adult; D003715:Dengue / Q000453:epidemiology / Q000208:ethnology / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods*; D011446:Prospective Studies; D057566:Self Report; D012846:Singapore / Q000453:epidemiology / Q000208:ethnology; D055815:Young Adult