The contribution of dormant origins to genome stability: from cell biology to human genetics.
The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a strong selective pressure on the positioning of licensed origins. In light of this, we discuss the complex and disparate phenotypes observed in mouse models and humans patients that arise due to defects in replication licensing proteins.
Centre for Gene Regulation & Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Robert C
RC
Alver
Centre for Gene Regulation & Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Gaganmeet Singh
GS
Chadha
Centre for Gene Regulation & Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. Electronic address: j.j.blow@dundee.ac.uk.
J Julian
JJ
Blow
D000818:Animals; D004261:DNA Replication / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005826:Genetics, Medical; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D051379:Mice; D064110:Minichromosome Maintenance Proteins / Q000235:genetics; D008938:Mitosis / Q000235:genetics; D018741:Replication Origin / Q000235:genetics*
D004268:DNA-Binding Proteins; D064110:Minichromosome Maintenance Proteins
Dormant origins; MCM2–7; Meier–Gorlin; Origin licensing; Pre-RC; Replication origins