Antioxidants: potential antiviral agents for Japanese encephalitis virus infection.
Japanese encephalitis (JE) is prevalent throughout eastern and southern Asia and the Pacific Rim. It is caused by the JE virus (JEV), which belongs to the family Flaviviridae. Despite the importance of JE, little is known about its pathogenesis. The role of oxidative stress in the pathogenesis of viral infections has led to increased interest in its role in JEV infections. This review focuses mainly on the role of oxidative stress in the pathogenesis of JEV infection and the antiviral effect of antioxidant agents in inhibiting JEV production. First, this review summarizes the pathogenesis of JE. The pathological changes include neuronal death, astrocyte activation, and microglial proliferation. Second, the relationship between oxidative stress and JEV infection is explored. JEV infection induces the generation of oxidants and exhausts the supply of antioxidants, which activates specific signaling pathways. Finally, the therapeutic efficacy of a variety of antioxidants as antiviral agents, including minocycline, arctigenin, fenofibrate, and curcumin, was studied. In conclusion, antioxidants are likely to be developed into antiviral agents for the treatment of JE.
Department of Histology and Embryology, School of Basic Medicine, Third Military Medical University, Chongqing 400038, PR China; Squadron 13 of Cadet Brigade, College of Medical Laboratory Technology, Third Military Medical University, Chongqing, PR China.
Yu
Y
Zhang
Department of Histology and Embryology, School of Basic Medicine, Third Military Medical University, Chongqing 400038, PR China; Squadron 17, College of Preventive Medicine, Third Military Medical University, Chongqing, PR China.
Zehua
Z
Wang
Department of Histology and Embryology, School of Basic Medicine, Third Military Medical University, Chongqing 400038, PR China; Squadron 13 of Cadet Brigade, College of Medical Laboratory Technology, Third Military Medical University, Chongqing, PR China.
Huan
H
Chen
Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China. Electronic address: 442653949@qq.com.
Zongtao
Z
Chen
Department of Histology and Embryology, School of Basic Medicine, Third Military Medical University, Chongqing 400038, PR China. Electronic address: tianyp1981@aliyun.com.
Yanping
Y
Tian
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D016923:Cell Death / Q000187:drug effects; D003474:Curcumin / Q000627:therapeutic use; D004664:Encephalitis Virus, Japanese / Q000187:drug effects / Q000502:physiology; D004672:Encephalitis, Japanese / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011345:Fenofibrate / Q000627:therapeutic use; D005663:Furans / Q000627:therapeutic use; D006801:Humans; D017705:Lignans / Q000627:therapeutic use; D017628:Microglia / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008911:Minocycline / Q000627:therapeutic use; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*
D000975:Antioxidants; D000998:Antiviral Agents; D005663:Furans; D017705:Lignans; D008911:Minocycline; D003474:Curcumin; D011345:Fenofibrate; C071942:arctigenin
Antioxidant; Antivirus agents; Japanese encephalitis virus; Oxidative stress