Targeting mycobacterial proteolytic complexes with natural products.
Controlled proteolysis is key to bacterial viability. In this issue of Chemistry & Biology, Gavrish and colleagues characterize a natural product, lassomycin, targeting the Mycobacterium tuberculosis caseinolytic (Clp) protease. Unusually, lassomycin activates ClpC1, inducing ATPase activity and decoupling it from proteolysis.
TB Discovery Research, Infectious Disease Research Institute, Seattle, WA 98102, USA. Electronic address: tanya.parish@idri.org.
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D049069:ATP-Dependent Proteases / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; D011480:Protease Inhibitors; C000595674:lassomycin; D049069:ATP-Dependent Proteases