Nickel-catalyzed cross-coupling of aryl fluorides and organozinc reagents.
Ni(PCy3)2Cl2 was demonstrated to effectively catalyze cross-coupling of aryl fluorides and organozinc reagents. Both electron-poor and -rich aryl fluorides can react effectively with nucleophiles including aryl-, methyl-, and benzylzinc chlorides. A wide range of substituents and functional groups are tolerated. In the presence of a directing group, PhC(O), the reaction is selective for cleavage of the C-F bond ortho to the carbonyl substituent in a difluoroarene.
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, People's Republic of China.
Feng
F
Zhu
Zhong-Xia
ZX
Wang