Meet the terminator: The phosphatase PP2A puts brakes on IRF-3 activation.
Cellular interferon response to microbial infection is transient. In a recent paper in Immunity, Long et al. (2014) identify protein phosphatase 2A (PP2A) as a deactivator of phospho-interferon regulatory factor 3, the key transcription factor for interferon synthesis, thus providing one basis for the observed transiency.
Department of Molecular Genetics, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Saurabh
S
Chattopadhyay
Department of Molecular Genetics, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. Electronic address: seng@ccf.org.
Ganes C
GC
Sen
D000818:Animals; D006801:Humans; D050838:Interferon Regulatory Factor-3 / Q000378:metabolism*; D007370:Interferon Type I / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D054648:Protein Phosphatase 2 / Q000378:metabolism*; D000075370:Receptors for Activated C Kinase; D051196:Toll-Like Receptor 3 / Q000378:metabolism*; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
D050838:Interferon Regulatory Factor-3; D007370:Interferon Type I; D009479:Neuropeptides; C090294:RACK1 protein, mouse; D000075370:Receptors for Activated C Kinase; D051196:Toll-Like Receptor 3; D051197:Toll-Like Receptor 4; D054648:Protein Phosphatase 2