Biomarkers of liver fibrosis.
Liver fibrosis is the final common pathway for almost all causes of chronic liver injury. Liver fibrosis is now known to be a dynamic process having significant potential for resolution. Therefore, fibrosis prediction is an essential part of the assessment and management of patients with chronic liver disease. As such, there is strong demand for reliable liver biomarkers that provide insight into disease etiology, diagnosis, therapy, and prognosis in lieu of more invasive approaches such as liver biopsy. Current diagnostic strategies range from use of serum biomarkers to more advanced imaging techniques including transient elastography and magnetic resonance imaging. In addition to these modalities, there are other approaches including the use of novel, but yet to be validated, biomarkers. In this chapter, we discuss the biomarkers of liver fibrosis including the use of invasive and noninvasive biomarkers and disease-specific biomarkers in various chronic liver diseases.
Ki Tae
KT
Suk
Dae Yong
DY
Kim
Kyoung Min
KM
Sohn
Dong Joon
DJ
Kim
D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002908:Chronic Disease; D003094:Collagen / Q000097:blood*; D003663:Decision Trees; D018450:Disease Progression; D054459:Elasticity Imaging Techniques; D006801:Humans; D006975:Hypertension, Portal; D007797:Laminin / Q000097:blood*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging; D020782:Matrix Metalloproteinases / Q000097:blood; D015233:Models, Statistical; D011379:Prognosis
D015415:Biomarkers; D007797:Laminin; D003094:Collagen; D020782:Matrix Metalloproteinases