Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice.
We validated the utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy (1H MRS) as an adjunct screening technique for dementia due to Alzheimer's disease (AD). We examined the posterior cingulate gyri of 228 subjects using VSRAD and 1H MRS in addition to conventional cerebrospinal fluid biomarkers at baseline. At the 3-year follow-up, the 228 subject were classified as follows: 93 healthy subjects, 42 MCI-non-converters (MCI-NC), 25 MCI-converters to AD (MCI-C), 44 AD, 8 dementia with Lewy bodies (DLB), 5 normal pressure hydrocephalus, and 11 patients with other neurological diseases. Our results demonstrated that subjects with increased medial temporal atrophy (MTA) severity on VSRAD, increased Cho/Cr, MI/Cr ratio, and decreased NAA/Cr and NAA/MI ratio on 1H MRS at baseline were at risk of dementia due to AD. Receiver operating characteristic analysis showed that severity of MTA and the NAA/MI ratio distinguished patients with AD and MCI-C from controls. Furthermore, the 118 subjects without dementia and MTA showing only a decreased NAA/MI ratio at baseline developed to MCI-C, AD, and DLB 3 years later. 1H MRS detected biochemical abnormalities preceding brain atrophy and cognitive decline. VSRAD combined with 1H MRS may be routinely applied to screen for MCI/AD and prodromal AD in clinical practice.
Higashi Matsudo Municipal Hospital, Matsudo, Takatsuka shinden, Japan.
Masaaki
M
Waragai
Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Hokkaido, Japan.
Saori
S
Hata
Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Hokkaido, Japan.
Toshiharu
T
Suzuki
Department of Molecular Pathobiology of Brain Diseases (Department of Neurology), Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Ryotaro
R
Ishii
Department of Molecular Pathobiology of Brain Diseases (Department of Neurology), Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Chihiro
C
Fujii
Department of Molecular Pathobiology of Brain Diseases (Department of Neurology), Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Takahiko
T
Tokuda
Department of Geriatrics & Gerontology, Division of Brain Science Institute of Development, Aging and Cancer Tohoku University, Tohoku, Japan.
Hiroyuki
H
Arai
Division of Geriatric Pharmacotherapy, Institute of Development, Aging and Cancer, Tohoku University, Tohoku, Japan.
Takashi
T
Ohrui
National Hospital Organization, Kurihama Medical and Addiction Center, Kanagawa, Japan.
Susumu
S
Higuchi
Amine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba, Japan.
Madoka
M
Yoshida
Amine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba, Japan.
Kazuei
K
Igarashi
Higashi Matsudo Municipal Hospital, Matsudo, Takatsuka shinden, Japan.
Masaru
M
Moriya
Higashi Matsudo Municipal Hospital, Matsudo, Takatsuka shinden, Japan.
Naomichi
N
Iwai
Higashi Matsudo Municipal Hospital, Matsudo, Takatsuka shinden, Japan.
Kenichi
K
Uemura
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000150:complications*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000473:pathology*; D002794:Choline / Q000378:metabolism; D003704:Dementia / Q000175:diagnosis* / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D012189:Retrospective Studies; D014316:Tritium
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); D014316:Tritium; D001224:Aspartic Acid; C000179:N-acetylaspartate; D002794:Choline
Alzheimer's disease; SPM8 plus DARTEL (VSRAD); magnetic resonance imaging; magnetic resonance spectroscopy ($^1$H MRS); screening; surrogate marker