[The use of diuretics in kidney disease].
BACKGROUND
Diuretics are an important part of the therapy for a number of medical conditions such as heart, liver and kidney failure and hypertension. This article presents updated knowledge on the use of diuretics in kidney disease.


METHODS
The article is based on a literature search in PubMed, information obtained from textbooks on neurophysiology and kidney disease and on the authors' clinical experience.


RESULTS
Kidney disease affects the pharmacokinetics and pharmacodynamics of diuretics, and this must be taken into account when selecting a drug and determining the dosage. This applies particularly to nephrotic syndrome and severe chronic renal disease (GFR < 30 ml/min/1.73 m²).


CONCLUSIONS
Knowledge of the pharmacology of diuretics is crucial to the rational use of diuretics in renal disease. Dose titration under close clinical monitoring and an optimal dosage interval make it possible to find the lowest possible effective dose and reduce the occurrence of side effects.
Avdeling for nyresykdommer St. Olavs hospital.
Lene
L
Heramb
Avdeling for nyresykdommer St. Olavs hospital og Institutt for kreftforskning og molekylær medisin Det medisinske fakultet Norges teknisk-naturvitenskapelige universitet.
Stein
S
Hallan
Avdeling for nyresykdommer St. Olavs hospital og Institutt for kreftforskning og molekylær medisin Det medisinske fakultet Norges teknisk-naturvitenskapelige universitet.
Knut
K
Aasarød
D004232:Diuretics / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D004351:Drug Resistance; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy*; D007684:Kidney Tubules / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D004232:Diuretics; D012964:Sodium