Development and validation of a computational model of the knee joint for the evaluation of surgical treatments for osteoarthritis.
A three-dimensional (3D) knee joint computational model was developed and validated to predict knee joint contact forces and pressures for different degrees of malalignment. A 3D computational knee model was created from high-resolution radiological images to emulate passive sagittal rotation (full-extension to 65°-flexion) and weight acceptance. A cadaveric knee mounted on a six-degree-of-freedom robot was subjected to matching boundary and loading conditions. A ligament-tuning process minimised kinematic differences between the robotically loaded cadaver specimen and the finite element (FE) model. The model was validated by measured intra-articular force and pressure measurements. Percent full scale error between FE-predicted and in vitro-measured values in the medial and lateral compartments were 6.67% and 5.94%, respectively, for normalised peak pressure values, and 7.56% and 4.48%, respectively, for normalised force values. The knee model can accurately predict normalised intra-articular pressure and forces for different loading conditions and could be further developed for subject-specific surgical planning.
a Medical Engineering Research Group, Faculty of Science and Technology, Anglia Ruskin University , Chelmsford, Essex , UK.
R
R
Mootanah
C W
CW
Imhauser
F
F
Reisse
D
D
Carpanen
R W
RW
Walker
M F
MF
Koff
M W
MW
Lenhoff
S R
SR
Rozbruch
A T
AT
Fragomen
Z
Z
Dewan
Y M
YM
Kirane
K
K
Cheah
J K
JK
Dowell
H J
HJ
Hillstrom
D000465:Algorithms; D001696:Biomechanical Phenomena; D002356:Cartilage / Q000502:physiology; D003198:Computer Simulation; D020342:Finite Element Analysis; D006801:Humans; D007719:Knee Joint / Q000033:anatomy & histology* / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008953:Models, Anatomic; D010003:Osteoarthritis / Q000601:surgery*; D011312:Pressure; D016059:Range of Motion, Articular; D012399:Rotation; D016474:Weight-Bearing
in vitro cadaveric test; knee joint contact mechanics; lower limb malalignment; model validation; osteoarthritis; subject-specific finite element knee model