Residues of antibacterial drugs in honey from the Italian market.
Antibacterial drugs are used worldwide for the control of American and, less often, European foulbrood. Their administration is mostly uncontrolled and applied without approved protocols and instructions for use as well as precautionary recommendations. Consequently, this practice is responsible for the contamination of beehive products and contributes to the problem of food safety. According to this situation, 4672 analyses were carried out on 5303 honeys collected from 2001 to 2007. These samples were investigated for antibacterial residues of tetracyclines, sulphonamides, streptomycin, chloramphenicol and tylosin. Honeys were classified according to their origin: imported honey and honey from the Italian market. In the last group (only for samples collected from 2001 to 2004), another type of honey was distinguished: that of local honey. A total of 6.3% of all samples were positive for the antibacterial drugs analysed; in particular, 6.8% of imported honeys and 6.1% of honeys on the Italian market. Only 1.7% of local honey had antibacterial residues. These results are indicative of a rather frequent presence of antibacterial drug residues in both Italian and imported honeys. Furthermore, the data showed that among the active substances analysed, sulphonamides are the most used antibacterial substance followed by tetracyclines, streptomycin, tylosin, and chloramphenicol. Finally, a continuous monitoring programme is needed, accompanied by an education programme to beekeepers on proper hive management.
a National Reference Laboratory for Beekeeping.
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Baggio
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Gallina
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Benetti
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Mutinelli
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000633:toxicity; D056630:Beekeeping; D001516:Bees; D002701:Chloramphenicol / Q000032:analysis / Q000633:toxicity; D004350:Drug Residues / Q000032:analysis* / Q000633:toxicity; D005504:Food Analysis / Q000379:methods; D005506:Food Contamination / Q000032:analysis*; D006722:Honey / Q000032:analysis* / Q000633:toxicity; D006801:Humans; D007558:Italy; D013307:Streptomycin / Q000032:analysis / Q000633:toxicity; D013449:Sulfonamides / Q000032:analysis / Q000633:toxicity; D013754:Tetracyclines / Q000032:analysis / Q000633:toxicity; D015645:Tylosin / Q000032:analysis / Q000633:toxicity
D000900:Anti-Bacterial Agents; D013449:Sulfonamides; D013754:Tetracyclines; D002701:Chloramphenicol; D013307:Streptomycin; D015645:Tylosin
animal; antibiotics; chromatography–high-performance liquid chromatography (HPLC); honey; veterinary drug residues