Rats of hypertensive ISIAH strain are resistant to the development of metabolic syndrome induced by high-fat diet.
We studied the influence of high-fat diet on the development of metabolic syndrome in rats of hypertensive ISIAH strain and normotensive WAG strain. In contrast to ISIAH rats, high-fat diet in WAG rats led visceral obesity, glucose tolerance, and dyslipidemia. DNA-binding activity of the peroxisome proliferator-activated receptor α (PPARα) decreased in the liver of WAG rats and increased in ISIAH rats. Blood levels of TNF-α, IL-6, and corticosterone increased more significantly in WAG rats. Corticosterone content in the adrenal glands was more markedly reduced in WAG rats. High-fat diet had no effect on BP in ISIAH and WAG rats. It was concluded that ISIAH rats can be used as a genetic model in studies of the mechanism of resistance to the metabolic syndrome.
Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia, midushkin@soramn.ru.
M I
MI
Dushkin
M V
MV
Khrapova
G G
GG
Kovshik
M I
MI
Chasovskikh
V G
VG
Selyatitskaya
N A
NA
Palchikova
D000302:Adrenal Cortex / Q000473:pathology; D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D004822:Epididymis / Q000473:pathology; D018149:Glucose Intolerance; D006973:Hypertension / Q000378:metabolism* / Q000473:pathology; D050152:Intra-Abdominal Fat / Q000473:pathology; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology* / Q000473:pathology; D009929:Organ Size; D051381:Rats