Enantioselective acute toxicity effects and bioaccumulation of furalaxyl in the earthworm (Eisenia foetida).
The enantioselectivities of individual enantiomers of furalaxyl in acute toxicity and bioaccumulation in the earthworm (Eisenia foetida) were studied. The acute toxicity was tested by filter paper contact test. After 48 h of exposure, the calculated LC50 values of the R-form, rac-form, and S-form were 2.27, 2.08, and 1.22 µg cm(-2), respectively. After 72 h of exposure, the calculated LC50 values were 1.90, 1.54, and 1.00 µg cm(-2), respectively. Therefore, the acute toxicity of furalaxyl enantiomers was enantioselective. During the bioaccumulation experiment, the enantiomer fraction of furalaxyl in earthworm tissue was observed to deviate from 0.50 and maintained a range of 0.55-0.60; in other words, the bioaccumulation of furalaxyl was enantioselective in earthworm tissue with a preferential accumulation of S-furalaxyl. The uptake kinetic of furalaxyl enantiomers fitted the first-order kinetics well and the calculated kinetic parameters were consistent with the low accumulation efficiency.
Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Fang
F
Qin
Yongxin
Y
Gao
Baoyuan
B
Guo
Peng
P
Xu
Jianzhong
J
Li
Huili
H
Wang
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000737:chemistry / Q000633:toxicity; D005659:Fungicides, Industrial / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity*; D005663:Furans / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity*; D007700:Kinetics; D007928:Lethal Dose 50; D008956:Models, Chemical; D009835:Oligochaeta / Q000737:chemistry / Q000378:metabolism*; D012987:Soil / Q000737:chemistry; D012989:Soil Pollutants; D013237:Stereoisomerism
D005659:Fungicides, Industrial; D005663:Furans; D012987:Soil; D012989:Soil Pollutants; C490004:furalaxyl
acute toxicity; bioaccumulation; earthworm; enantioselectivity; furalaxyl