Continuous spikes and waves during slow sleep in a child with karyotype 47, XYY.
The XYY syndrome is a sex chromosome aneuploidy occurring in one of 1,000 live male births. Only few data exist regarding the correlation between this syndrome and epilepsy. An EEG pattern suggestive of benign focal epilepsy with centro-temporal spikes has recently been described in four XYY patients. We report the first patient with XYY trisomy, rolandic spikes, and atypical evolution with continuous spikes and waves during slow sleep (CSWSS). The present report suggests that the association between an EEG pattern similar to that of BECTS and 47, XYY karyotype may not be coincidental. Moreover, we show that an atypical evolution with CSWSS may occur in this chromosomal disorder.
Regional Epilepsy Centre, Azienda Bianchi-Melacrino-Morelli Hospital, Reggio Calabria.
Vittoria
V
Cianci
Regional Epilepsy Centre, Azienda Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Department of Medical and Surgical Sciences, Magna Græcia University, Catanzaro.
Edoardo
E
Ferlazzo
Pediatric Unit, San Francesco di Paola Hospital, Paola (CS).
Giuseppe
G
De Martino
Pediatric Unit, Azienda Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Italy.
Angela
A
Vinci
Regional Epilepsy Centre, Azienda Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Department of Medical and Surgical Sciences, Magna Græcia University, Catanzaro.
Sara
S
Gasparini
Regional Epilepsy Centre, Azienda Bianchi-Melacrino-Morelli Hospital, Reggio Calabria.
Giovanbattista Gaspare
GG
Tripodi
Regional Epilepsy Centre, Azienda Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Department of Medical and Surgical Sciences, Magna Græcia University, Catanzaro.
Umberto
U
Aguglia
D000927:Anticonvulsants / Q000627:therapeutic use; D004569:Electroencephalography; D019305:Epilepsy, Rolandic / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008297:Male; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D025064:Sex Chromosome Disorders / Q000503:physiopathology*; D012890:Sleep / Q000502:physiology*; D014314:Trisomy; D014997:XYY Karyotype / Q000503:physiopathology*
D000927:Anticonvulsants
CSWSS; centro-temporal spikes; chromosomal disorder; seizure