Photo-controllable molecular hydrogels for drug delivery.
A photocleavable nitrobenzyl ester group was introduced in the backbone of self-assembling peptides using standard Fmoc-peptide systhesis. The nitrobenzyl ester group could be used as a cleavable linker to connect a gelator and a hydrophilic group. Photo-irradiation would lead to the generation of the molecular gelator and the formation of a molecular hydrogel. The nitrobenzyl ester group could also be used as one part of hydrophobic capping group for short peptides to produce molecular hydrogelators. In this case, photo-irradiation would lead to the release of hydrophobic anti-imflammatory drug of Naproxen and the gel-sol phase transition. The application of photocleavable group in molecular self-assembly would lead to photo-controllable self-assembly materials for controlled drug release, tissue engineering, and regenerative medicine.
Hanxia
H
Liu
Zhijian
Z
Song
Xuemei
X
Chen
D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000528:radiation effects; D004058:Diffusion; D020100:Hydrogels / Q000737:chemistry* / Q000528:radiation effects; D008027:Light; D053769:Nanocapsules / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure; D009288:Naproxen / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D010778:Photochemotherapy / Q000379:methods
D003692:Delayed-Action Preparations; D020100:Hydrogels; D053769:Nanocapsules; D009288:Naproxen