ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes.
Persistent presence of ATP4A autoantibodies (ATP4AA) directed towards parietal cells is typical for atrophic body gastritis (ABG), an autoimmune disease associated with type 1 diabetes. We assessed whether Helicobacter pylori (Hp) infection might be associated with positivity for ATP4AA in children with type 1 diabetes. Sera were collected from 70 (38♀) type 1 diabetes children [aged 13·2 ± 4·5 years, age at diagnosis 8·8 ± 4·3 years, diabetes duration 4·5 ± 3·8 years, mean HbA1c 7·8 ± 1·6% (62 ± 17·5 mmol/mol)] seen at the regional diabetes clinic in Katowice, Poland. Patients were tested concurrently for Hp infection by means of a 13C urea breath test. ATP4AA were measured using a novel radioimmunoprecipitation assay developed at the Barbara Davies Center for Childhood Diabetes, University of Colorado. ATP4AA were present in 21 [30%, 95% confidence interval (CI) = 19-41%] and Hp infection was detected in 23 (33%, 95% CI = 22-44%) children. There was no statistically significant association between ATP4AA presence and Hp status. ATP4AA presence was not associated with current age, age at type 1 diabetes diagnosis, diabetes duration or current HbA1c. ATP4AA were more prevalent in females [42% (26-58%)] than males [16% (3-28%)], P = 0·016. ATP4A are found in nearly one-third of children with type 1 diabetes and more common among females. In this cross-sectional analysis, Hp infection was not associated with autoimmunity against parietal cells.
Clinical Hospital No1, Zabrze, Poland.
A
A
Chobot
J
J
Wenzlau
K
K
Bak-Drabik
J
J
Kwiecien
J
J
Polanska
M
M
Rewers
D000293:Adolescent; D001327:Autoimmune Diseases / Q000276:immunology / Q000382:microbiology; D015551:Autoimmunity; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000382:microbiology*; D005260:Female; D017506:H(+)-K(+)-Exchanging ATPase / Q000097:blood / Q000276:immunology*; D016481:Helicobacter Infections / Q000276:immunology / Q000382:microbiology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D012737:Sex Factors; D055815:Young Adult
C000591756:ATP4A protein, human; D017506:H(+)-K(+)-Exchanging ATPase
Helicobacter pylori; autoantibodies; autoimmune gastritis; parietal cell; type 1 diabetes