The impact of leucoaraiosis on neurological function recovery in elderly patients with acute cerebral infarction: Clinical study involving 279 Chinese patients.
OBJECTIVE
To explore the link between leucoaraiosis and recovery of neurological function in elderly patients with acute cerebral infarction.


METHODS
The study included elderly patients, hospitalized with acute cerebral infarction. Magnetic resonance imaging examinations were performed before or within 5 days after admission; T1-weighted, T2-weighted, fluid-attenuated inversion recovery and diffusion-weighted imaging sequence data were collected. Using the Fazekas scale, leucoaraiosis (white matter hyperintensity [WMH]) was graded as 0 (absent), 1 (mild), 2 (moderate) or 3 (severe) for all participants.


RESULTS
The study included 279 patients. WMH grades of 0, 1, 2 and 3 were seen in 27 (9.67%), 90 (32.26%), 104 (37.28%) and 58 cases (20.79%) respectively. Improvement on the National Institutes of Health Stroke Scale for neurological impairment was negatively associated with WMH grade. Patients with severe leucoaraiosis at hospital admission had worse neurological functional recovery and a higher rate of self-care incapability compared with those with mild or no leucoaraiosis.


CONCLUSIONS
The results suggest that severe leucoaraiosis in elderly patients with acute cerebral infarction is associated with poor prognosis and poor recovery of neurological function.
Department of Neurology, Beijing Military General Hospital, Beijing, China.
Yong-hua
YH
Huang
Department of Neurology, Beijing Military General Hospital, Beijing, China.
Zhen-xi
ZX
Xia
Department of Neurology, Beijing Military General Hospital, Beijing, China zhangvivian@vip.sina.com.
Wei
W
Wei
Department of Neurology, Beijing Military General Hospital, Beijing, China.
Guan-ran
GR
Gao
Department of Neurology, Beijing Military General Hospital, Beijing, China.
Jing-jing
JJ
Gong
Department of Neurology, Beijing Military General Hospital, Beijing, China.
Ying
Y
Li
Department of Neurology, Beijing Military General Hospital, Beijing, China.
Wei-wei
WW
Zhang
D000203:Activities of Daily Living; D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000534:rehabilitation*; D003071:Cognition; D038524:Diffusion Magnetic Resonance Imaging; D056344:Executive Function; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000534:rehabilitation*; D008297:Male; D020127:Recovery of Function; D066127:White Matter / Q000473:pathology* / Q000503:physiopathology
Leucoaraiosis; National Institutes of Health Stroke Scale; acute cerebral infarction; diffusion-weighted imaging; neurological recovery; outcome