Ca-carboxymethyl xanthan gum mini-matrices: Swelling, erosion and their impact on drug release mechanism.
The effect of Ca(2+) ion concentration on swelling, erosion, and drug release mechanism of Ca(2+) ion cross-linked carboxymethyl xanthan gum (Ca-CMXG) matrices was investigated. By adding CaCl2 solution, carboxymethyl xanthan gum (CMXG) was converted into Ca-CMXG matrix, which was evaluated for swelling, erosion and drug release in different dissolution media. The amount of Ca(2+) ion alters the viscosity of gel layer formed around the matrices resulting in decreased water penetration into swollen layer. The changes in amount of Ca(2+) ion considerably influenced the swelling and erosion of the matrix leading to different drug release profiles. The simultaneous swelling and erosion of matrices that were controlled by the degree of cross-linking prejudiced the drug release mechanism. The release data fitted well into the Korsmeyer-Peppas equation and the combined effect of diffusion and erosion described the overall drug transport mechanism.
Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
Siddhartha
S
Maity
Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address: biswanathsa2003@yahoo.com.
Biswanath
B
Sa
D002152:Calorimetry, Differential Scanning; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D011239:Prednisolone / Q000494:pharmacology; D066244:Proton Magnetic Resonance Spectroscopy; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D014783:Viscosity; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D011135:Polysaccharides, Bacterial; D012996:Solutions; D014867:Water; D011239:Prednisolone; C002563:xanthan gum
Carboxymethyl xanthan gum; Drug release; Erosion; Ionic cross-linked matrix; Swelling