Association of a TNIP1 polymorphism with Vogt-Koyanagi-Harada syndrome but not with ocular Behcet's disease in Han Chinese.
OBJECTIVE
The aim of the study was to investigate the association of TNFα-induced protein 3 interacting with protein 1 (TNIP1) gene polymorphisms with Vogt-Koyanagi-Harada (VKH) syndrome and Behcet's disease (BD) in a Han Chinese population.


METHODS
A total of 656 BD patients, 961 VKH syndrome patients and 1534 healthy controls were included in this two-stage case control study. Seven SNPs, including rs17728338, rs7708392, rs10036748, rs3762999, rs999556, rs4958881 and rs3792783, belonging to TNIP1 were genotyped and analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The data were analyzed by using the χ2 or Fisher's exact test and corrected for multiple comparisons by the Bonferroni method.


RESULTS
A significantly increased frequency of the GG genotype and a decreased frequency of the AG genotype of rs17728338 were found in VKH patients (Pc = 0.038 OR = 1.934, 95% CI  = 1.438 ∼ 2.601). No significant difference was noted in allele or genotype frequencies of rs7708392, rs10036748, rs3762999, rs999556, rs4958881 and rs3792783, between VKH patients and healthy controls (Pc>0.05). No significant difference was noted in allele or genotype frequencies of the tested 7 SNPs between BD patients and healthy controls. Analysis of extraocular clinical findings, did not reveal an association of the TNIP1 gene polymorphisms with BD or VKH syndrome subgroups.


CONCLUSIONS
A TNIP1 polymorphism may be a risk factor for VKH syndrome in Han Chinese.
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yanyun
Y
Shi
Shanxi Eye Hospital, Taiyuan, Shanxi, China.
Yading
Y
Jia
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China.
Shengping
S
Hou
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jing
J
Fang
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yan
Y
Zhou
University Eye Clinic Maastricht, Maastricht, Limburg, The Netherlands.
Aize
A
Kijlstra
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China.
Peizeng
P
Yang
D000328:Adult; D044466:Asian People / Q000208:ethnology* / Q000235:genetics; D001528:Behcet Syndrome / Q000235:genetics*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D014607:Uveomeningoencephalitic Syndrome / Q000235:genetics*
D004268:DNA-Binding Proteins; C117046:TNIP1 protein, human