anti-Markovnikov hydroamination of alkenes catalyzed by a two-component organic photoredox system: direct access to phenethylamine derivatives.
Disclosed herein is a general catalytic system for the intermolecular anti-Markovnikov hydroamination of alkenes. By using an organocatalytic photoredox system, α- and β-substituted styrenes as well as aliphatic alkenes undergo anti-Markovnikov hydroamination. Heterocyclic amines were also successfully employed as nitrogen nucleophiles, thus providing a direct route to heterocyclic motifs common in medicinal agents.
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290 (USA) http://www.chem.unc.edu/people/faculty/nicewicz/
Tien M
TM
Nguyen
Namita
N
Manohar
David A
DA
Nicewicz
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010627:Phenethylamines / Q000737:chemistry*; D010777:Photochemistry
D000475:Alkenes; D010627:Phenethylamines
alkenes; amines; organocatalysis; photochemistry; radicals