Reproducibility of histogram and texture parameters derived from intravoxel incoherent motion diffusion-weighted MRI of FN13762 rat breast Carcinomas.
OBJECTIVE
To determine the reproducibility of histogram and texture parameters derived from intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) of FN13762 rat breast carcinomas.


METHODS
IVIM diffusion-weighted MRI was performed twice, nine days after tumor implantation in 11 rats. At each session, histogram and texture parameters of entire tumors were extracted from apparent diffusion coefficient (ADC), true-diffusion coefficient (Dt), pseudo-diffusion coefficient (Dp), and perfusion fraction (Pf) maps. Intraobserver and interscan measurement reproducibilities were evaluated using intraclass correlation coefficients (ICC).


RESULTS
Mean, entropy, 5th, 10th, 25th percentiles from ADC and Dt maps revealed good intra-observer and interscan agreements [lower limits of 95% confidence interval (CI) for ICC≥0.75]. However, all parameters from Dp and Pf maps gave relatively poor intra-observer and interscan agreements (lower limits of 95% CI for ICC<0.75).


CONCLUSIONS
Histogram and texture parameters derived from ADC and Dt maps were more reproducible than those from Dp and Pf maps.
Department of Radiology, Seoul National University Hospital, 101, Daehangno, Jongno-gu, Seoul 110-744, Korea. cmpark@radiol.snu.ac.kr.
Yong Sub
YS
Song
Chang Min
CM
Park
Sang Min
SM
Lee
Sang Joon
SJ
Park
Hye Rim
HR
Cho
Seung Hong
SH
Choi
Jeong Min
JM
Lee
Berthold
B
Kiefer
Jin Mo
JM
Goo
D000818:Animals; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D009038:Motion; D051381:Rats; D011916:Rats, Inbred F344; D015203:Reproducibility of Results
FN13762 rat breast carcinoma; Reproducibility; diffusion-weighted MRI; histogram; intravoxel incoherent motion; texture