Extracortical origin of some murine subplate cell populations.
The subplate layer, the deepest cortical layer in mammals, has important roles in cerebral cortical development. The subplate contains heterogeneous cell populations that are morphologically diverse, with several projection targets. It is currently assumed that these cells are generated in the germinative zone of the earliest cortical neuroepithelium. Here we identify a pallial but extracortical area located in the rostromedial telencephalic wall (RMTW) that gives rise to several cell populations. Postmitotic neurons migrate tangentially from the RMTW toward the cerebral cortex. Most RMTW-derived cells are incorporated into the subplate layer throughout its rostrocaudal extension, with others contributing to the GABAergic interneuron pool of cortical layers V and VI.
Department of Molecular, Cellular, and Developmental Neurobiology, Instituto Cajal, 28002 Madrid, Spain and.
María
M
Pedraza
Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom.
Anna
A
Hoerder-Suabedissen
Department of Molecular, Cellular, and Developmental Neurobiology, Instituto Cajal, 28002 Madrid, Spain and.
María Amparo
MA
Albert-Maestro
Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom.
Zoltán
Z
Molnár
Department of Molecular, Cellular, and Developmental Neurobiology, Instituto Cajal, 28002 Madrid, Spain and decarlos@cajal.csic.es.
Juan A
JA
De Carlos
D000818:Animals; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D004622:Embryo, Mammalian / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D059330:GABAergic Neurons / Q000166:cytology / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D007395:Interneurons / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D049452:Green Fluorescent Proteins; D005680:gamma-Aminobutyric Acid
cell migration; pallium; preplate; projecting cells