Solid-phase extraction for selective determination of bisphenol A in drinks and fruits by dummy surface molecularly imprinted polymer with direct synthetic method.
A reliable and selective method was developed for the determination of bisphenol A (BPA) in drinks and fruit using dummy surface molecularly imprinted polymer (DSMIP) as a solid-phase extraction (SPE)-enrichment and separation sorbent coupled with high-performance liquid chromatography (HPLC). Tetrabromobisphenol A (TBBPA), whose structure is similar to BPA, was selected as a dummy template molecule. DSMIP has a higher selectivity for BPA than surface non-imprinted polymer (SNIP) when used as sorbents for SPE. Potential factors affecting the extraction efficiency, including conditioning, sample loading, washing and elution, and the breakthrough volume were optimised. Under the optimum experimental conditions, the recoveries of BPA in drinks and fruit were in the range from 98% to 105% with relative standard deviations (RSDs) below 7%, and a limit of detection (LOD) of 3 ng ml(-1). The developed extraction protocol eliminated the effect of template leakage on quantitative analysis and could be applied to the trace determination of BPA in complicated functional samples.
a Department of Chemistry , University of Science and Technology of China , Hefei , China.
Jin
J
Li
Hong
H
Zhou
Yu-Xin
YX
Liu
Xiang-Yang
XY
Yan
Ye-Ping
YP
Xu
Shao-Min
SM
Liu
D001559:Benzhydryl Compounds / Q000032:analysis* / Q000633:toxicity*; D001628:Beverages / Q000032:analysis / Q000633:toxicity; D002851:Chromatography, High Pressure Liquid; D005506:Food Contamination / Q000032:analysis*; D005638:Fruit / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D054802:Molecular Imprinting; D054118:Nanospheres / Q000737:chemistry / Q000648:ultrastructure; D010636:Phenols / Q000032:analysis* / Q000633:toxicity*; D011075:Polybrominated Biphenyls / Q000032:analysis; D011108:Polymers / Q000737:chemistry; D012822:Silicon Dioxide; D052616:Solid Phase Extraction / Q000379:methods*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D010636:Phenols; D011075:Polybrominated Biphenyls; D011108:Polymers; D012822:Silicon Dioxide; C020806:tetrabromobisphenol A; C006780:bisphenol A; D000098826:Bisphenol A Compounds
bisphenol A; drinks; dummy template; fruits; solid-phase extraction; surface molecular imprinting polymers