Innate immune cells in inflammation and cancer.
The innate immune system has evolved in multicellular organisms to detect and respond to situations that compromise tissue homeostasis. It comprises a set of tissue-resident and circulating leukocytes primarily designed to sense pathogens and tissue damage through hardwired receptors and eliminate noxious sources by mediating inflammatory processes. While indispensable to immunity, the inflammatory mediators produced in situ by activated innate cells during injury or infection are also associated with increased cancer risk and tumorigenesis. Here, we outline basic principles of innate immune cell functions in inflammation and discuss how these functions converge upon cancer development.
Authors' Affiliations: Howard Hughes Medical Institute, Chevy Chase, Maryland.
Roni
R
Nowarski
Nicola
N
Gagliani
Samuel
S
Huber
Richard A
RA
Flavell
D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology