Oxidative stress markers, cognitive functions, and psychosocial functioning in bipolar disorder: an empirical cross-sectional study.
OBJECTIVE
This study aimed to evaluate the relationship between oxidative stress markers and cognitive functions and domains of psychosocial functioning in bipolar disorder.


METHODS
Oxidative stress markers, cognitive functions, and domains of psychosocial functioning were evaluated in 51 patients with bipolar disorder who were in remission. Correlation analyses between these parameters were calculated with data controlled for duration of illness and number of episodes.


RESULTS
There was no statistically significant correlation between oxidative stress markers and cognitive functions. In terms of psychosocial functioning, significant correlations were found between malondialdehyde and sense of stigmatization (r = -0.502); household activities and superoxide dismutase (r = 0.501); participation in social activities and nitric oxide (r = 0.414); hobbies and leisure time activities and total glutathione (r = -0.567), superoxide dismutase (r = 0.667), and neurotrophin 4 (r = 0.450); and taking initiative and self-sufficiency and superoxide dismutase (r = 0.597). There was no correlation between other domains of psychosocial functioning and oxidative stress markers.


CONCLUSIONS
These results imply that oxidative stress markers do not appear to correlate clearly with cognitive impairment and reduced psychosocial functioning. However, there were some associations between selected oxidative markers and activity-oriented functional markers. This may represent a true negative association, or may be an artifact of oxidative stress being a state rather than a trait marker.
Department of Psychiatry, Celal Bayar University, Manisa, Turkey.
Ömer
Ö
Aydemir
Department of Psychiatry, Celal Bayar University, Manisa, Turkey.
Zeynep
Z
Çubukçuoğlu
Department of Psychiatry, Celal Bayar University, Manisa, Turkey.
Soner
S
Erdin
Department of Psychiatry, Celal Bayar University, Manisa, Turkey.
Cumhur
C
Taş
Department of Psychiatry, Celal Bayar University, Manisa, Turkey.
Ece
E
Onur
Department of Psychiatry, Celal Bayar University, Manisa, Turkey.
Michael
M
Berk
D000203:Activities of Daily Living; D000328:Adult; D015415:Biomarkers; D001714:Bipolar Disorder / Q000503:physiopathology* / Q000523:psychology*; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000503:physiopathology* / Q000523:psychology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D018384:Oxidative Stress / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D012917:Social Adjustment; D013997:Time Factors
D015415:Biomarkers