[Role of toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) in viral infections].
The immune system (IS) cells are capable of recognizing a wide variety of microorganisms, through receptors that are expressed and distributed throughout the cell architecture. The interaction between the pathogen-associated molecular patterns or damage-associated molecular patterns (PAMPs or DAMPs) and pattern recognition receptors (PRR), present in host cells, is a critical event that involves intracellular signaling processes that end up in the expression of both, proinflammatory and antiviral mediators. Accordingly, the proper functioning of the different mechanisms of signal transduction from the cell membrane to the cytoplasm will depend on the integrity of these receptors (PRR); and therefore, the IS response triggered against pathogens including viral agents. Hence, in this review we discuss the role of toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) in viral infections, using as evidence the studies in humans and mice known to date.
Anyelo
A
Durán
Melchor
M
Alvarez-Mon
Nereida
N
Valero
D000818:Animals; D053468:CARD Signaling Adaptor Proteins / Q000502:physiology*; D002352:Carrier Proteins / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D019143:Evolution, Molecular; D005544:Forecasting; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D018448:Models, Immunological; D005810:Multigene Family; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D053474:Nod1 Signaling Adaptor Protein / Q000502:physiology; D053473:Nod2 Signaling Adaptor Protein / Q000502:physiology*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D014777:Virus Diseases / Q000276:immunology*
D053468:CARD Signaling Adaptor Proteins; D002352:Carrier Proteins; D016207:Cytokines; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; C492716:Nlrp3 protein, mouse; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D051193:Toll-Like Receptors