Sarcoidosis as a systemic disease.
Sarcoidosis is a systemic disease, where for the abnormal localized collections of chronic inflammatory cells, the granuloma is cardinal, which may result in the formation of nodule(s) in the tissue of any organ of the body, with lungs and lymph nodes involvement being the most common. The granulomas are nonnecrotizing. The disease may either be asymptomatic or chronic. Its onset is gradual and may improve or clear up spontaneously. Clinical features of specific and nonspecific cutaneous lesions are described, emphasizing their role as a prelude to its systemic manifestations, afflicting respiratory, liver, spleen, musculoskeletal, ocular, cardiac, and neurologic systems. The salient briefs of diagnostic procedures are outlined, in addition to historical background and etiopathogenesis. Several currently available treatment modalities are outlined for instant reference.
Dermato-Venereology (Skin/VD) Center, Sehgal Nursing Home, A/6 Panchwati, Delhi-110 033, India. Electronic address: drsehgal@ndf.vsnl.net.in.
Virendra N
VN
Sehgal
Department of Dermatology Govt Medical College, Calicut, India.
Najeeba
N
Riyaz
Department of Dermatology, Bankura Sammilani Medical College, West Bengal, India.
Kingshuk
K
Chatterjee
Dr R.P. Center for Opthalmic Sciences AIIMS, New Delhi, India.
Pradeep
P
Venkatash
Department of Pathology, University College of Medical Sciences, and associated Guru Teg Bahadur Hospital, Shahdara Delhi, India.
Sonal
S
Sharma
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D012507:Sarcoidosis / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology*
D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents