Evaluation of oxidative stress and anti-oxidant status in essential hypertension.
The present study was planned to access the role of oxidative stress and anti-oxidant status in essential hypertension. Malondialdehyde is one of the by-products of lipid peroxidase and so extent of lipid peroxidation was measured by estimating malondialdehyde levels, nitrite concentration was used as an index of nitric oxide synthesis and anti-oxidant status was measured in terms of total antioxidant capacity. One hundred and eighty cases with essential hypertension and 60 volunteers as healthy controls were selected for the study. The subjects under study were grouped as pregeriatric (35-50 years) and geriatric (51-65 years). These cases were further subdivided into group I (mild), group II (moderate) and group III (severe), depending upon the levels of blood pressure. The study results showed statistically significant increased levels of serum malondialdehyde in all the groups of essential hypertensive patients when compared to that of healthy controls (p < 0.001), whereas levels of serum nitric oxide and total anti-oxidant capacity were significantly decreased in all groups of essential hypertensive patients when compared to those of controls (p < 0.001). These clear findings of the present study focuses the attention towards an alteration in the status of oxidants and anti-oxidant parameters indicating an impact of free radical action in the pathogenesis of essential hypertension.
Anup S
AS
Hendre
Anissa K
AK
Shariff
Sangita R
SR
Patil
Pushpa P
PP
Durgawale
Ajit V
AV
Sontakke
Adinath N
AN
Suryakar
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D000075222:Essential Hypertension; D006801:Humans; D006973:Hypertension / Q000097:blood*; D015227:Lipid Peroxidation / Q000502:physiology; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*
D000975:Antioxidants; D009569:Nitric Oxide; D008315:Malondialdehyde