Association study of 15q14 and 15q25 with high myopia in the Han Chinese population.
BACKGROUND
Refractive errors and high myopia are the most common ocular disorders, and both of them are leading causes of blindness in the world. Recently, genetic association studies in European and Japanese population identified that common genetic variations located in 15q14 and 15q25 were associated with high myopia. To validate whether the same variations conferred risk to high myopia in the Han Chinese population, we genotyped 1,461 individuals (940 controls and 521 cases samples) recruited of Han Chinese origin.


RESULTS
We found rs8027411 in 15q25 (P = 0.012 after correction, OR = 0.78) was significantly associated with high myopia but rs634990 in 15q14 (P = 0.54 after correction), OR = 0.88) was not.


CONCLUSIONS
Our findings supported that 15q25 is a susceptibility locus for high myopia, and gene RASGRF1 was possible to play a role in the pathology of high myopia.
Yu
Y
Qiang
Wenjin
W
Li
Qingzhong
Q
Wang
Kuanjun
K
He
Zhiqiang
Z
Li
Jianhua
J
Chen
Zhijian
Z
Song
Jia
J
Qu
Xiangtian
X
Zhou
Shengying
S
Qin
Jiawei
J
Shen
Zujia
Z
Wen
Jue
J
Ji
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, P,R China. yongyongshi@gmail.com.
Yongyong
Y
Shi
D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D002884:Chromosomes, Human, Pair 15; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult; D020666:ras-GRF1 / Q000235:genetics
C513039:RASGRF1 protein, human; D020666:ras-GRF1