Brain tissue properties differentiate between motor and limbic basal ganglia circuits.
Despite advances in understanding basic organizational principles of the human basal ganglia, accurate in vivo assessment of their anatomical properties is essential to improve early diagnosis in disorders with corticosubcortical pathology and optimize target planning in deep brain stimulation. Main goal of this study was the detailed topological characterization of limbic, associative, and motor subdivisions of the subthalamic nucleus (STN) in relation to corresponding corticosubcortical circuits. To this aim, we used magnetic resonance imaging and investigated independently anatomical connectivity via white matter tracts next to brain tissue properties. On the basis of probabilistic diffusion tractography we identified STN subregions with predominantly motor, associative, and limbic connectivity. We then computed for each of the nonoverlapping STN subregions the covariance between local brain tissue properties and the rest of the brain using high-resolution maps of magnetization transfer (MT) saturation and longitudinal (R1) and transverse relaxation rate (R2*). The demonstrated spatial distribution pattern of covariance between brain tissue properties linked to myelin (R1 and MT) and iron (R2*) content clearly segregates between motor and limbic basal ganglia circuits. We interpret the demonstrated covariance pattern as evidence for shared tissue properties within a functional circuit, which is closely linked to its function. Our findings open new possibilities for investigation of changes in the established covariance pattern aiming at accurate diagnosis of basal ganglia disorders and prediction of treatment outcome.
Department of Neurology, Charité University Medicine Berlin, Berlin, Germany; LREN, Département des Neurosciences Cliniques, CHUV, Université de Lausanne, Lausanne, Switzerland; Berlin Center for Advanced Neuroimaging, Charité Universitätsmedizin, Berlin, Germany.
Ettore A
EA
Accolla
Juergen
J
Dukart
Gunther
G
Helms
Nikolaus
N
Weiskopf
Ferath
F
Kherif
Antoine
A
Lutti
Rumana
R
Chowdhury
Stefan
S
Hetzer
John-Dylan
JD
Haynes
Andrea A
AA
Kühn
Bogdan
B
Draganski
D000328:Adult; D000368:Aged; D001479:Basal Ganglia / Q000033:anatomy & histology*; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging; D005260:Female; D007839:Functional Laterality; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000033:anatomy & histology*; D011336:Probability; D020531:Subthalamic Nucleus / Q000033:anatomy & histology*; D066127:White Matter / Q000033:anatomy & histology*
MT; R2*; diffusion-weighted imaging; multiparameter mapping; voxel-based quantification