The effect of feto-maternal blood type incompatibility on development of gestational diabetes mellitus.
OBJECTIVE
To assess the relation between fetal and maternal blood type (ABO, Rh) incompatibility and development of gestational diabetes mellitus (GDM).


METHODS
A total of 500 pregnant women underwent diagnostic test for GDM by a 100-g oral glucose tolerance test (OGTT) after an 8 to 12-h overnight fast participated in this study. OGTT was performed between the 24-28 weeks of gestation, but participants who were at high risk for GDM were tested after the first prenatal visit. In the postpartum period, maternal and infant blood types were determined. Presence of GDM was evaluated in terms of matched and unmatched fetal and maternal ABO and Rh blood types separately.


RESULTS
GDM was detected in 235 participants. Unmatched ABO blood types between the mother-infant pairs were present in 44.7% (n=105) of GDM (+) and 35.8 % (n=95) of GDM (-) patients. Incompatible feto-maternal ABO blood type was positively correlated with development of GDM which was marginally significant. (p=0.045; R=1.2;95% CL; 1.004-1.48). However, Rh feto-maternal blood type incompatibility was not related with development of GDM.


CONCLUSIONS
Feto-maternal ABO blood type incompatibility may be a weak risk factor for the development of GDM.
Departments of Internal Medicine, Istanbul Medipol University, Istanbul.
M
M
Kanat
Departments of Pediatrics, Izzet Baysal Women's and Children's Hospital, Bolu.
S B
SB
Goksugur
Departments of Obstetrics and Gynecology, Medical School, University of Abant Izzet Baysal, Bol.
T
T
Ozlu
Departments of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul.
A
A
Tunckale
Departments of Endocrinology and Metabolism, University of Ege, Izmir.
B
B
Ozturk
Departments of Endocrinology and Metabolism, Sisli Etfal Training and Research Hospital, Istanbul.
F Y
FY
Ozturk
Departments of Endocrinology and Metabolism, Sisli Etfal Training and Research Hospital, Istanbul.
Y
Y
Altuntas
Departments of Internal Medicine, University of Acibadem, Istanbul.
Y
Y
Suleymanoglu
Departments of Endocrinology and Metabolism, University of Ondokuz Mayıs, Samsun.
H
H
Atmaca
Departments of Endocrinology and Metabolism, Haydarpasa Training and Research Hospital, Istanbul.
N
N
Yolcu
Departments of Endocrinology and Metabolism, Haydarpasa Training and Research Hospital, Istanbul.
I
I
Gonenc
Departments of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara.
T
T
Delibasi
Departments of Endocrinology and Metabolism, Sisli Etfal Training and Research Hospital, Istanbul.
S
S
Zuhur
Departments of 1Internal Medicine, Istanbul Medipol University, Istanbul.
O
O
Dikbas
Departments of 1Internal Medicine, Istanbul Medipol University, Istanbul.
G
G
Aktas
Faculty of Economics and Administrative Sciences, University of Abant Izzet Baysal, Bolu.
Y
Y
Karagoz
Division of Diabetes, University of Texas Health Science Center at San Antonio, Texas, USA.
M A
MA
Abdul-Ghani
D000017:ABO Blood-Group System; D000328:Adult; D016640:Diabetes, Gestational / Q000209:etiology*; D005260:Female; D006801:Humans; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000150:complications*; D012307:Risk Factors
D000017:ABO Blood-Group System