Reliability of negative BOLD in ipsilateral sensorimotor areas during unimanual task activity.
Research using functional magnetic resonance imaging has for numerous years now reported the existence of a negative blood oxygenation level dependent (BOLD) response. Based on accumulating evidence, this negative BOLD signal appears to represent an active inhibition of cortical areas in which it is found during task activity. This particularly important with respect to motor function given that it is fairly well-established that, in younger adults, the ipsilateral sensorimotor cortex exhibits negative BOLD during unimanual movements in fMRI. This interhemispheric suppression of cortical activity may have useful implications for our understanding of both basic motor function and rehabilitation of injury or disease. However, to date, we are aware of no study that has tested the reliability of evoked negative BOLD in ipsilateral sensorimotor cortex in individuals across sessions. The current study employs a unimanual finger opposition task previously shown to evoke negative BOLD in ipsilateral sensorimotor cortex across three sessions. Reliability metrics across sessions indicates that both the magnitude and location of ipsilateral sensorimotor negative BOLD response is relatively stable over each of the three sessions. Moreover, the volume of negative BOLD in ipsilateral cortex was highly correlated with volume of positive BOLD activity in the contralateral primary motor cortex. These findings show that the negative BOLD signal can be reliably evoked in unimanual task paradigms, and that the signal dynamic could represent an active suppression of the ipsilateral sensorimotor cortex originating from the contralateral motor areas.
Department of Veterans Affairs Center for Visual and Neurocognitive Rehabilitation, Atlanta, GA, USA, keith.mcgregor@emory.edu.
Keith M
KM
McGregor
Atchar
A
Sudhyadhom
Joe
J
Nocera
Ari
A
Seff
Bruce
B
Crosson
Andrew J
AJ
Butler
D000328:Adult; D001931:Brain Mapping / Q000379:methods; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D005385:Fingers / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D010100:Oxygen / Q000097:blood*; D015203:Reproducibility of Results; D066191:Sensorimotor Cortex / Q000502:physiology*; D013997:Time Factors; D055815:Young Adult
D010100:Oxygen