Hysteroscopic morcellation compared with electrical resection of endometrial polyps: a randomized controlled trial.
OBJECTIVE
To evaluate whether hysteroscopic morcellation or bipolar electrosurgical resection is more favorable for removing endometrial polyps in an office setting in terms of feasibility, speed, pain, and acceptability.


METHODS
A multicenter, single-blind, randomized, controlled trial of office hysteroscopic morcellation compared with electrosurgical resection was conducted. A total of 121 women were randomly allocated to polyp removal by one of the two methods in an office setting. The outcomes assessed were time taken to complete the endometrial polypectomy, defined as the time from insertion to removal of vaginal instrumentation, completeness of polyp removal, acceptability, and pain measured on a 100-mm visual analog scale.


RESULTS
The median time taken to complete the procedure was 5 minutes and 28 seconds for morcellation compared with 10 minutes and 12 seconds for electrosurgical resection (P<.001). The polyps were completely removed in 61 out of 62 (98%) women assigned to morcellation compared with 49 out of 59 (83%) women treated with electrosurgical resection (odds ratio 12.5; 95% confidence interval [CI] 1.5-100.6; P=.02). The mean pain scores during the procedure favored morcellation by 16.1 points on average (35.9 compared with 52.0; 95% CI for difference, -24.7 to -7.6; P<.001). Overall, 99% of women found office polypectomy to be acceptable, with only one woman in the electrosurgical resection group considering the procedure unacceptable.


CONCLUSIONS
In comparison to electrosurgical resection during hysteroscopic polypectomy, morcellation was significantly quicker, less painful, more acceptable to women, and more likely to completely remove endometrial polyps compared with electrosurgical resection.


BACKGROUND
ClinicalTrials.gov, www.clinicaltrials.gov, NCT01509313.
Birmingham Women's Hospital, Birmingham and Sheffield University Hospital, Sheffield, United Kingdom.
Paul P
PP
Smith
Lee J
LJ
Middleton
Mary
M
Connor
T Justin
TJ
Clark
D000328:Adult; D000368:Aged; D004598:Electrosurgery; D005260:Female; D006801:Humans; D015907:Hysteroscopy / Q000379:methods*; D008875:Middle Aged; D011127:Polyps / Q000601:surgery*; D016037:Single-Blind Method; D013048:Specimen Handling / Q000379:methods; D014591:Uterine Diseases / Q000601:surgery*