Current ante-mortem techniques for diagnosis of bovine tuberculosis.
Bovine tuberculosis (TB), mainly caused by Mycobacterium bovis, is a zoonotic disease with implications for Public Health and having an economic impact due to decreased production and limitations to the trade. Bovine TB is subjected to official eradication campaigns mainly based on a test and slaughter policy using diagnostic assays based on the cell-mediated immune response as the intradermal tuberculin test and the gamma-interferon (IFN-γ) assay. Moreover, several diagnostic assays based on the detection of specific antibodies (Abs) have been developed in the last few years with the aim of complementing the current diagnostic techniques in the near future. This review provides an overview of the current ante-mortem diagnostic tools for diagnosis of bovine TB regarding historical background, methodologies and sensitivity (Se) and specificity (Sp) obtained in previous studies under different epidemiological situations.
MAEVA SERVET SL, C/ de la Fragua 3, 28749, Alameda del Valle, Madrid, Spain; Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain. Electronic address: jbezosga@gmail.com.
Javier
J
Bezos
Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain.
Carmen
C
Casal
Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain.
Beatriz
B
Romero
Prionics AG, Wagistrasse 27A, 8952 Schlieren-Zürich, Switzerland.
Bjoern
B
Schroeder
Prionics AG, Wagistrasse 27A, 8952 Schlieren-Zürich, Switzerland.
Roland
R
Hardegger
Prionics AG, Wagistrasse 27A, 8952 Schlieren-Zürich, Switzerland.
Alex J
AJ
Raeber
INGENASA, C/ Hermanos García Noblejas 39, 28037, Madrid, Spain.
Lissette
L
López
INGENASA, C/ Hermanos García Noblejas 39, 28037, Madrid, Spain.
Paloma
P
Rueda
Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain; Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Lucas
L
Domínguez
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D002417:Cattle; D003933:Diagnosis; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000187:drug effects / Q000378:metabolism; D009163:Mycobacterium bovis / Q000276:immunology*; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000379:methods*; D014373:Tuberculin / Q000494:pharmacology; D014374:Tuberculin Test / Q000379:methods*; D014380:Tuberculosis, Bovine / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology
D000907:Antibodies, Bacterial; D014373:Tuberculin; D007371:Interferon-gamma
Cattle; Gamma-interferon assay; Serology; Tuberculin test; Tuberculosis