Physical inactivity and long-term rates of community-acquired sepsis.
OBJECTIVE
The authors sought to determine the association between physical inactivity (characterized by exercise and television watching levels) and long-term rates of community-acquired sepsis.


METHODS
The study utilized a population-based cohort of 30,183 adult (≥45 years) community dwelling adults. Subjects reported weekly exercise (low=none, medium=1-3times/week, high=≥4times/week) and daily television watching (low=<1h/day, medium=1-3h/day, high=≥4h/day) levels. The authors evaluated the association between exercise, television watching and rates of sepsis, defined as hospital treatment for a serious infection with ≥2 Systemic Inflammatory Response Syndrome (SIRS) criteria.


RESULTS
Among 30,183 participants, 1500 experienced a sepsis event. Reported weekly exercise was: high 8798 (29.2%), medium 10,695 (35.4%), and low 10,240 (33.9%). Where available, reported daily television watching was: low 4615 (19.6%), medium 11,587 (49.3%) and high 7317 (31.1%). Decreased weekly exercise was associated with increased adjusted sepsis rates (high - referent; medium - HR 1.02, 95% CI 0.96-1.20; low - 1.33, 1.13-1.56). Daily television watching was not associated with sepsis rates. Sepsis rates were highest among those with both low exercise and high television watching levels (HR 1.49, 95% CI: 1.10-2.01).


CONCLUSIONS
Physical inactivity may be associated with increased long-term rates of community-acquired sepsis.
Department of Emergency Medicine, University of Alabama School of Medicine, USA. Electronic address: hwang@uabmc.edu.
Henry E
HE
Wang
Division of Infectious Diseases, Department of Medicine, University of Alabama School of Medicine, USA.
John
J
Baddley
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, USA.
Russell L
RL
Griffin
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, USA.
Suzanne
S
Judd
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, USA.
George
G
Howard
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, USA.
John P
JP
Donnelly
Division of Preventive Medicine, Department of Medicine, University of Alabama School of Medicine, USA.
Monika M
MM
Safford
D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D005260:Female; D006801:Humans; D007107:Immune System / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D011159:Population Surveillance / Q000379:methods; D057185:Sedentary Behavior; D018805:Sepsis / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D014481:United States / Q000453:epidemiology
Diet; Epidemiology; Exercise; Infections; Physical activity; Sedentary behavior; Sepsis