[Serum interleukin-18 level in precancerous conditions and gastric cancer].
The purpose of the study--to determine the serum concentration and the pathogenetic significance of changes of interleukin-18 in patients with chronic atrophic gastritis, peptic ulcer disease and gastric cancer. MATERIAL AND METHODS.:A comprehensive survey of 192 patients with diseases gastroduodenal zone. Diagnostic emphasis was placed on ELISA method as defined in the serum of IL-18, --1beta, interferon-gamma, kantsernogo antigen 19-9, vascular endothelial growth factor, total antibodies to CagA Helicobacter pylori.


RESULTS
We examined patients revealed an increase in the concentration of interleukin-18, which correlated with tumor stage, the level of vascular endothelial growth factor, total antibodies to CagA Helicobacter pylori.


CONCLUSIONS
The data obtained allow to recommend the use of interleukin-18 in serum for diagnostic of atrophic gastritis, peptic ulcer diseases and gastric cancer.
L V
LV
Matveeva
L M
LM
Mosina
D000942:Antigens, Bacterial / Q000097:blood / Q000276:immunology; D001426:Bacterial Proteins / Q000097:blood / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D005757:Gastritis, Atrophic / Q000097:blood* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D011230:Precancerous Conditions / Q000097:blood* / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology; D013274:Stomach Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology; D013276:Stomach Ulcer / Q000097:blood* / Q000276:immunology / Q000382:microbiology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D020382:Interleukin-18; C080866:cagA protein, Helicobacter pylori