Cellular players in skeletal muscle regeneration.
Skeletal muscle, a tissue endowed with remarkable endogenous regeneration potential, is still under focused experimental investigation mainly due to treatment potential for muscle trauma and muscular dystrophies. Resident satellite cells with stem cell features were enthusiastically described quite a long time ago, but activation of these cells is not yet controlled by any medical interventions. However, after thorough reports of their existence, survival, activation, and differentiation there are still many questions to be answered regarding the intimate mechanism of tissue regeneration. This review delivers an up-to-date inventory of the main known key players in skeletal muscle repair, revealed by various models of tissue injuries in mechanical trauma, toxic lesions, and muscular dystrophy. A better understanding of the spatial and temporal relationships between various cell populations, with different physical or paracrine interactions and phenotype changes induced by local or systemic signalling, might lead to a more efficient approach for future therapies.
Department of Cell Biology and Histology, School of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari, 050474 Bucharest, Romania ; Department of Molecular Medicine and Neuroscience, "Victor Babes," Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania.
Laura Cristina
LC
Ceafalan
Department of Molecular Medicine and Neuroscience, "Victor Babes," Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania ; Department of Neurology, Colentina Clinical Hospital (CDPC), School of Medicine, "Carol Davila" University of Medicine and Pharmacy, 19-21 Sos. Stefan cel Mare, 020125 Bucharest, Romania.
Bogdan Ovidiu
BO
Popescu
Department of Cell Biology and Histology, School of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari, 050474 Bucharest, Romania ; Department of Molecular Medicine and Neuroscience, "Victor Babes," Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania.
Mihail Eugen
ME
Hinescu
D002454:Cell Differentiation / Q000235:genetics; D019070:Cell Lineage / Q000235:genetics; D006801:Humans; D018482:Muscle, Skeletal / Q000254:growth & development / Q000378:metabolism*; D009136:Muscular Dystrophies / Q000628:therapy*; D012038:Regeneration; D015398:Signal Transduction / Q000235:genetics; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*