Silver-catalyzed oxidative activation of benzylic C-H bonds for the synthesis of difluoromethylated arenes.
A mild and catalytic method to form difluoromethylated arenes through the activation of benzylic C-H bonds has been developed. Utilizing AgNO3 as the catalyst, various arenes with diverse functional groups undergo activation/fluorination of benzylic C-H bonds with commercially available Selectfluor reagent as a source of fluorine in aqueous solution. The reaction is operationally simple and amenable to gram-scale synthesis.
State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071 (China).
Peng
P
Xu
Shuo
S
Guo
Liyan
L
Wang
Pingping
P
Tang
D002384:Catalysis; D005461:Fluorine / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012834:Silver / Q000737:chemistry*
D005461:Fluorine; D012834:Silver
CH activation; arenes; fluorination; silver; synthetic methods