B7-H3 was highly expressed in human primary hepatocellular carcinoma and promoted tumor progression.
B7-H3 has been detected in different cancers and correlated to tumor progression and outcome in cancer patients. In this study, we investigated the expression of B7-H3 in tissues and cells of primary hepatocellular carcinoma (PHC) patients. The research showed that B7-H3 is aberrantly expressed in PHC tissues and cells, and its high expression on HepG2 cells significantly promotes cell proliferation, adhesion, migration, and invasion capacity; moreover, it inhibits the proliferation of CD8(+) T cells. Thus, B7-H3 may have a critical role in PHC and it may enhance tumor escape from the immune surveillance of CD8(+) T cells.
1Department of Immunology, Binzhou Medical University, Yantai, P.R. China.
Feifei
F
Wang
Guoyan
G
Wang
Tongshen
T
Liu
Guohua
G
Yu
Guangbo
G
Zhang
Xiying
X
Luan
D060887:B7 Antigens / Q000096:biosynthesis* / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D063646:Carcinogenesis; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D019139:Tumor Escape
D060887:B7 Antigens; C423237:CD276 protein, human
B7-H3; CD8+ T cells; HepG2; Primary hepatocellular carcinoma