Incidence of gestational trophoblastic disease in Tokat province, Turkey.
OBJECTIVE
This study investigated the incidence of gestational trophoblastic disease (GTD) in Tokat province, Turkey.


METHODS
The medical records of patients who had been diagnosed and treated at one university hospital, six government hospitals, and one specialist hospital in Tokat province between January 2005 and December 2012 were evaluated retrospectively.


RESULTS
During the study period, there were 59,754 births and GTD was diagnosed in 73 cases. The calculated GTD incidence was 1.22/1000. The mean age of the patients diagnosed with GTD was 28.6±7.3 (range 17-51) years. In GTD, complete moles occurred in 26%, partial moles in 74%, and no invasive moles, choriocarcinomas, or placental site trophoblastic tumours were found. Only two patients received chemotherapy (methotrexate). There was no mortality associated with the disease during follow-up.


CONCLUSIONS
The incidence of GTD in Tokat province was 1.2 per 1000 births. Early diagnosis, treatment, and follow-up play a critical role in preventing the morbidity and mortality associated with disease. The incidence of GTD, which has a high recovery rate with adequate treatment and follow-up, can be determined from regional and community-based research.
Department of Obstetrics and Gynecology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Bülent
B
Cakmak
Department of Obstetrics and Gynecology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Muhammet
M
Toprak
Department of Obstetrics and Gynecology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Mehmet Can
MC
Nacar
Department of Pathology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
Reşid Doğan
RD
Köseoğlu
Department of Obstetrics and Gynecology, Tokat Government Hospital, Tokat, Turkey.
Nihan
N
Güneri
Gestational trophoblastic disease; incidence; molar pregnancy