Glucose-regulated protein 78 and heparanase expression in oral squamous cell carcinoma: correlations and prognostic significance.
BACKGROUND
The aim of the present study was to investigate the expression of glucose-related protein 78 (GRP78) and heparanase (HPA) in oral squamous cell carcinoma (OSCC) and their relationship with clinicopathological parameters and potential implications for survival.


METHODS
A total of 46 patients with OSCC and 10 normal individuals were recruited for the study. GRP78 and HPA expression were determined in the lesion tissues using immunohistochemical analysis. The correlation between GRP78 and HPA was assessed using the Spearman correlation analysis. The associations of GRP78 and HPA with clinicopathological characteristics and survival were examined using the x2-test, Kaplan-Meier, or Cox regression.


RESULTS
Patients with OSCC showed a statistically significant higher prevalence of GRP78 and HPA expression than normal oral tissues. GRP78 and HPA expression was positively correlated with size, TNM stage, histological grade, lymphatic metastasis, and distant metastasis in OSCC patients. GRP78 expression was also positively correlated with HPA expression. Positive GRP78 and HPA expression was inversely correlated with survival in OSCC patients.


CONCLUSIONS
HPA expression was found to be positively correlated with GRP78 expression. GRP78 and HPA are biomarkers that may have the potential to guide the treatment of oral cancer patients.
Fei
F
Xia
Department of Stomatology, The First Affiliated Hospital of Bengbu Medical College, No 287, Chang-Huai Road, Bengbu 233000, Anhui, People's Republic of China. xjch9999@163.com.
Jin Cheng
JC
Xu
Pei
P
Zhang
Yuan Yuan
YY
Zhang
Qian Wen
QW
Zhang
Zhen Hua
ZH
Chao
Fang
F
Wang
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000401:mortality / Q000556:secondary*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D000091342:Endoplasmic Reticulum Chaperone BiP; D005260:Female; D005500:Follow-Up Studies; D005966:Glucuronidase / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult; D000099175:Heparanase
D014408:Biomarkers, Tumor; D000091342:Endoplasmic Reticulum Chaperone BiP; D005966:Glucuronidase; D006360:Heat-Shock Proteins; D000099175:Heparanase; C000717247:HSPA5 protein, human