An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss.
Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) can provide a microenvironmental niche that alters the default healing response toward a constructive and functional outcome. The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients. Porcine urinary bladder ECM scaffold implantation was associated with perivascular stem cell mobilization and accumulation within the site of injury, and de novo formation of skeletal muscle cells. The ECM-mediated constructive remodeling was associated with stimulus-responsive skeletal muscle in rodents and functional improvement in three of the five human patients.
McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Brian M
BM
Sicari
J Peter
JP
Rubin
Christopher L
CL
Dearth
Matthew T
MT
Wolf
Fabrisia
F
Ambrosio
Michael
M
Boninger
Neill J
NJ
Turner
Douglas J
DJ
Weber
Tyler W
TW
Simpson
Aaron
A
Wyse
Elke H P
EH
Brown
Jenna L
JL
Dziki
Lee E
LE
Fisher
Spencer
S
Brown
Stephen F
SF
Badylak
D000818:Animals; D005109:Extracellular Matrix / Q000737:chemistry; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism*; D013552:Swine; D054457:Tissue Scaffolds; D001743:Urinary Bladder / Q000737:chemistry*