miRNAs for the detection of multidrug resistance: overview and perspectives.
The goal of the present paper is to establish and validate the link between cancer diagnosis and therapy by microRNAs detection. The induction in vitro of some specific microRNAs after treatment with MDR ligands has been outlined. Starting from the results obtained by in vitro induction of MDCK and MDCK-MDR1 cells treated by a MDR1 ligand, a new scenario in the early diagnosis and chemotherapy could be disclosed. To corroborate this perspective a short overview on pancreatic cancer diagnosis and chemotherapeutic treatment has been reported.
Institute for Biomedical Technologies, CNR Bioinformatics and Genomics Research Group, Via Amendola 122/D, Bari 70126, Italy. andreas.gisel@ba.itb.cnr.it.
Andreas
A
Gisel
Institute for Biomedical Technologies, CNR Bioinformatics and Genomics Research Group, Via Amendola 122/D, Bari 70126, Italy. mirna.valvano@libero.it.
Mirna
M
Valvano
Biofordrug srl, Università degli Studi di Bari, via Orabona 4, Bari 70125, Italy. gha_imane@yahoo.it.
Imane Ghafir
IG
El Idrissi
Clinical and Preclinical Pharmacology Laboratory, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, Bari 70124, Italy. p.nardulli@oncologico.bari.it.
Patrizia
P
Nardulli
Clinical and Preclinical Pharmacology Laboratory, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, Bari 70124, Italy. a.azzariti@oncologico.bari.it.
Amalia
A
Azzariti
Università degli Studi di Bari "Aldo Moro", Via Orabona 4, Bari 70125, Italy. antonio.carrieri@uniba.it.
Antonio
A
Carrieri
Università degli Studi di Bari "Aldo Moro", Via Orabona 4, Bari 70125, Italy. marialessandra.contino@uniba.it.
Marialessandra
M
Contino
Biofordrug srl, Università degli Studi di Bari, via Orabona 4, Bari 70125, Italy. nicolaantonio.colabufo@uniba.it.
Nicola Antonio
NA
Colabufo
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000818:Animals; D004285:Dogs; D018432:Drug Resistance, Multiple / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006801:Humans; D061985:Madin Darby Canine Kidney Cells; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D035683:MicroRNAs