Glycogen phosphorylase BB levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertion.
BACKGROUND
Transjugular intrahepatic portosystemic shunts (TIPS) have become a widely accepted tool in the treatment of patients with symptomatic portal hypertension. The aim of our study was to assess glycogen phosphorylase BB (GPBB) concentration in relation to echocardiographic and haemodynamic parameters in patients before and after TIPS insertion.


METHODS
The study population consisted of 55 patients (38 men and 17 women, age 55.6±8.9 years, range 37-74 years) with liver cirrhosis treated with transjugular portosystemic shunting. GPBB, echocardiographic, and haemodynamic parameters were measured before TIPS insertion and 24 h after the procedure. GPBB concentrations were assessed using the Cardiac Array for Evidence Investigator protein biochip. Correlation between parameters was assessed using the Spearman's coefficient.


RESULTS
Serum post-procedural GPBB concentrations were increased in comparison with baseline (5.58 vs. 2.67 μg/L, P<0.001). GPBB concentration after TIPS significantly correlated with baseline systemic vascular resistence (r=0.330; P=0.017) and cardiac index (r=0.313; P=0.025).


CONCLUSIONS
GPBB concentration measurement may be a useful tool for monitoring myocardial ischemia during a TIPS procedure.
Institute of Clinical Biochemistry and Diagnostics, University Hospital in Hradec Kralove, Czech Republic.
Martina
M
Vasatova
1st Department of Internal Medicine - Cardioangiology, University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University in Prague.
Radek
R
Pudil
Department of Oncology, 1st Faculty of Medicine, Charles University in Prague and Thomayer University Hospital, Prague.
Tomas
T
Buchler
Institute of Clinical Biochemistry and Diagnostics, University Hospital in Hradec Kralove, Czech Republic.
Iva
I
Karesova
2nd Department of Internal Medicine-Gastroenterology, University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University in Prague.
Vaclav
V
Safka
2nd Department of Internal Medicine-Gastroenterology, University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University in Prague.
Tomas
T
Fejfar
2nd Department of Internal Medicine-Gastroenterology, University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University in Prague.
Petr
P
Hulek
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002405:Catheterization, Central Venous; D005260:Female; D024981:Glycogen Phosphorylase / Q000097:blood*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D006975:Hypertension, Portal / Q000201:enzymology* / Q000209:etiology / Q000601:surgery; D008103:Liver Cirrhosis / Q000150:complications / Q000201:enzymology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D019168:Portasystemic Shunt, Transjugular Intrahepatic; D012720:Severity of Illness Index
D015415:Biomarkers; D024981:Glycogen Phosphorylase; C528446:glycogen phosphorylase BB, human
TIPS; biochip; cardiac marker; cirrhosis; glycogen phosphorylase BB; portal hypertension