Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen.
The role of the circulating renin-angiotensin system (RAS) in regulating systemic blood pressure and sodium balance is well established. More recently, researchers have turned their focus to the local generation of angiotensin II (Ang II) in specific tissues. Matsusaka et al. revisit the renal RAS and provide evidence that liver-derived angiotensinogen (AGT) is a major determinant of renal Ang II levels in a model of podocyte injury.
Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina, USA.
David I
DI
Ortiz-Melo
Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina, USA.
Robert F
RF
Spurney
D000804:Angiotensin II / Q000378:metabolism*; D000808:Angiotensinogen / Q000378:metabolism*; D000818:Animals; D007674:Kidney Diseases / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D050199:Podocytes / Q000378:metabolism*
C534932:Agt protein, mouse; D000808:Angiotensinogen; D000804:Angiotensin II