Transport of DNA in hydrophobic microchannels: a dissipative particle dynamics simulation.
In this work, we numerically study a new means of manipulating single DNA chains in microchannels. The method is based on the effect of finite slip at hydrophobic walls on the hydrodynamics and, consequently, on the dynamics of the DNA in microchannels. We use dissipative particle dynamics to study DNA transport as a function of chain length and the Reynolds number in two dimensional parallel plate channels. We show how an asymmetric velocity profile in a channel with hydrophobic and hydrophilic walls can be used to manipulate the location of the DNA molecules. Using this effect, we propose a simple arrangement of hydrophobic and hydrophilic strips which can be exploited to separate long and short DNA chains.
Department of Applied Mechanics, Indian Institute of Technology Madras, India. ranjith_s_kumar@yahoo.com bsvp@iitm.ac.in.
S Kumar
SK
Ranjith
B S V
BS
Patnaik
Srikanth
S
Vedantam
D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular
D004247:DNA