Au(I)-catalyzed triple bond alkoxylation/dienolether aromaticity-driven cascade cyclization to naphthalenes.
A novel strategy for the synthesis of multisubstituted naphthalenes was developed via a Au(i)-catalyzed alkyne alkoxylation/dienolether aromaticity-driven cascade cyclization using 1,5-enyne substrates. The functional group toleration was examined by synthesizing a series of substrates and the mechanism was also studied based on intermediates isolated through deuterium labeling experiments.
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, P. R. China. yongxiang.liu@syphu.edu.cn mscheng@syphu.edu.cn.
Yongxiang
Y
Liu
Jia
J
Guo
Yang
Y
Liu
Xiaoyu
X
Wang
Yanshi
Y
Wang
Xinyu
X
Jia
Gaofei
G
Wei
Lizhu
L
Chen
Jianyong
J
Xiao
Maosheng
M
Cheng
D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D050607:Organogold Compounds / Q000737:chemistry*
D009281:Naphthalenes; D050607:Organogold Compounds; D006046:Gold