[Systemic cytomegalovirus infection: changes in serum calcium and magnesium levels with foscarnet treatment].
Cytomegalovirus infection is common in cardiac transplant patients. Foscarnet is used, with limited evidence, as second-line treatment after ganciclovir failure in these patients. We describe the case of a paediatric cardiac transplant patient who developed electrolyte disturbances during foscarnet treatment for cytomegalovirus infection. The infection resolved after 6 weeks of treatment. Low ionized calcium and magnesium levels were observed during the drug infusion, which were treated with supplements. The serum levels reverted to normal after drug withdrawal.
Servicio de Farmacia, Hospital General Universitario Gregorio Marañón, Madrid, España. Electronic address: bmarzal@gmail.com.
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Marzal-Alfaro
Servicio de Farmacia, Hospital General Universitario Gregorio Marañón, Madrid, España.
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Manrique-Rodríguez
Unidad de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Madrid, España.
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Alcaraz Romero
Unidad de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Madrid, España.
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García San Prudencio
Servicio de Farmacia, Hospital General Universitario Gregorio Marañón, Madrid, España.
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Fernández-Llamazares
D000998:Antiviral Agents / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood*; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000097:blood* / Q000188:drug therapy*; D017245:Foscarnet / Q000627:therapeutic use*; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008297:Male
D000998:Antiviral Agents; D017245:Foscarnet; D008274:Magnesium; D002118:Calcium
Foscarnet, Citomegalovirus, Hipocalcemia, Hipomagnesemia, Reacción adversa; Foscarnet, Cytomegalovirus, Hypocalcemia, Hypomagnesemia, Adverse drug reaction