Comparison of viral burden and disease progression in Chinese-origin rhesus macaques infected with common experimentally applied chimeric virus: SHIV-1157ipd3N4, SHIV-162P3, or SHIV-KB9.
BACKGROUND
Little is known about the comparative susceptibility and differential pathogenic characteristics of Chinese-origin rhesus macaques upon infection with the chimeric SHIVs most commonly applied in experimental research.


METHODS
In vivo infectivity, viral replication, and disease progression related to SHIV-1157ipd3N4, SHIV-162P3, and SHIV-KB9 infections were assessed after intravenous inoculation of Chinese-origin rhesus macaques (n = 10 each).


RESULTS
SHIV-KB9-infected monkeys had higher plasma viral loads than those infected with SHIV-1157ipd3N4 or SHIV-162P3 (P < 0.05). The SHIV-KB9 group had a member that progressed rapidly to simian acquired immunodeficiency syndrome and was moribund at 155 days post-inoculation. SHIV-KB9 and SHIV-162P3 showed reverse trends in the effects on levels of memory T-cell subpopulations.


CONCLUSIONS
This study provides foundational data for future efficacy testing of candidate vaccine and antiviral therapy using a Chinese-origin rhesus macaque system.
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Chaoyang District, Beijing, China; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Chaoyang District, Beijing, China; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Chaoyang District, Beijing, China; Comparative Medical Center, Peking Union Medical College, Chaoyang District, Beijing, China.
Wei
W
Wang
Zhe
Z
Cong
Hong
H
Jiang
Ting
T
Chen
Guang
G
Jin
Jing
J
Xiong
Chuan
C
Qin
Qiang
Q
Wei
D000818:Animals; D018450:Disease Progression; D054884:Host-Pathogen Interactions; D016180:Lentivirus Infections / Q000276:immunology / Q000821:virology*; D017958:Lentiviruses, Primate / Q000502:physiology*; D018655:Lymphocyte Count; D008212:Lymphocyte Depletion; D008253:Macaca mulatta; D019562:Viral Load; D014779:Virus Replication
HIV/AIDS; SHIV; animal model; disease progression; monkey