Diarylheptanoids and phenylphenalenones from Musa itinerans fruits.
Two diarylheptanoids, musaitinerins A and B, one heterodimeric phenylphenalenone musaitinerone and four known phenylphenalenones, identified as 4-hydroxy-2-methoxy-9-phenyl-1H-phenalen-1-one, musanolone E, hydroxyanigorufone and irenolone were isolated from the fruits of Musa itinerans Cheesm. Their structures were elucidated using spectroscopic analyses. The antimicrobial activity of these compounds was evaluated against Escherichia coli, Staphylococcus aureus and Candida albicans; the cytotoxic activity of these compounds was also evaluated against human erythromyeloblastoid leukemia (K562) and human alveolar carcinoma epithelial (A549) cell lines, respectively. Musaitinerone and musanolone E exhibited weak effects against the A549 cell line, as compared with adriamycin. However, these two compounds did not exhibit any growth inhibition against K562 cells, S. aureus, E. coli or C. albicans. The other compounds were inactive against all of the tested cell lines and microorganisms, even at concentrations as high as 50 μM.
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Fang
F
Liu
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Yu
Y
Zhang
Key Laboratory of Chemistry for Natural Products, Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, People's Republic of China.
Qian-Yun
QY
Sun
Key Laboratory of Chemistry for Natural Products, Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, People's Republic of China.
Fu-Mei
FM
Yang
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Wei
W
Gu
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Jun
J
Yang
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Hong-Mei
HM
Niu
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address: wangyuehu@mail.kib.ac.cn.
Yue-Hu
YH
Wang
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, People's Republic of China; Yunnan Agricultural University, Kunming 650201, People's Republic of China. Electronic address: long@mail.kib.ac.cn.
Chun-Lin
CL
Long
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D036381:Diarylheptanoids / Q000737:chemistry* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D028521:Musa / Q000737:chemistry*; D043803:Phenalenes / Q000737:chemistry* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids; D043803:Phenalenes; D010936:Plant Extracts
Cytotoxicity; Diarylheptanoids; Musa itinerans; Musaceae; Phenylphenalenones