Multiple organ dysfunction syndrome in humans and animals.
Multiple organ dysfunction syndrome (MODS), defined as the presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention, is a cause of high morbidity and mortality in humans and animals. Many advances have been made in understanding the pathophysiology and treatment of this syndrome in human medicine, but much still is unknown. This comparative review will provide information regarding the history and pathophysiology of MODS in humans and discuss how MODS affects each major organ system in animals.
Pittsburgh Veterinary Specialty and Emergency Center, Pittsburgh, PA.
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K
Osterbur
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FA
Mann
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K
Kuroki
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A
DeClue
D000818:Animals; D002319:Cardiovascular System / Q000503:physiopathology; D002490:Central Nervous System / Q000503:physiopathology; D041981:Gastrointestinal Tract / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D009102:Multiple Organ Failure / Q000503:physiopathology / Q000662:veterinary*
Acute respiratory distress syndrome; Disseminated intravascular coagulation; Multiple organ failure; Sepsis