The serological profiles of subgroup of primary Sjögren's syndrome correlation with the clinical features of parotid glands.
OBJECTIVE
To investigate the difference of serological profile in pSS and their correlation with the clinical characteristics of parotid glands.


METHODS
This retrospective study includes 289 patients who fulfilled the 2002 American-European Consensus Group Criteria for pSS. The patients were categorized by the clinical features of parotid glands: Group 1 (massive group), Group 2 (infection group), Group 3 (swelling group) and Group 4 (others). The demographic data and serological profiles among these groups were compared. Statistical analyses of the results between groups were performed using the Student t test, Fisher's exact test, chi-square and analysis of variance.


RESULTS
There was a difference of serological profile in the different clinical characteristics of parotid glands of pSS. Serum Ig G value of Group 1 was the greatest, and complement C4 was lowest in the four groups. Serum Ig E value of Group 2 was the greatest and ESR of Group 3 was the greatest in the four groups.


CONCLUSIONS
This study has determined the differences of serological profile in the different clinical features of parotid glands of pSS patients, which may help advance our understanding of the disease and improve patient management.
Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Zhizaoju Road 639, Shanghai 200011, China.
LingYan
L
Zheng
Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Zhizaoju Road 639, Shanghai 200011, China. Electronic address: zhenglingyan73@163.com.
ChuangQi
C
Yu
Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Zhizaoju Road 639, Shanghai 200011, China.
Chi
C
Yang
Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Zhizaoju Road 639, Shanghai 200011, China.
LiSong
L
Xie
Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Zhizaoju Road 639, Shanghai 200011, China.
Huan
H
Shi
Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Zhizaoju Road 639, Shanghai 200011, China.
ZhiJun
Z
Wang
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001324:Autoantigens / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D004906:Erythrocyte Count; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology; D010306:Parotid Gland / Q000473:pathology*; D010309:Parotitis / Q000097:blood / Q000382:microbiology; D012189:Retrospective Studies; D012261:Ribonucleoproteins / Q000097:blood; D012859:Sjogren's Syndrome / Q000097:blood* / Q000473:pathology; D055815:Young Adult; D001613:beta 2-Microglobulin / Q000097:blood; D000097585:SS-B Antigen; D000099207:SS-A Antigen
D001324:Autoantigens; D002097:C-Reactive Protein; D003176:Complement C3; D003181:Complement C4; D006454:Hemoglobins; D007073:Immunoglobulin E; D007074:Immunoglobulin G; D012261:Ribonucleoproteins; D001613:beta 2-Microglobulin; D000097585:SS-B Antigen; D000099207:SS-A Antigen
Parotid gland; Primary Sjogren's syndrome; Serological profiles