Pre-induction with Mifepristone for Second Trimester Termination of Pregnancy.
OBJECTIVE
To study the efficacy and safety of combining mifepristone before misoprostol use in second trimester to considerably reduce the induction-abortion interval with the lowest possible dose and adverse reaction.


METHODS
A prospective study was conducted which included 60 patients visiting the antenatal OPD for elective abortions between 13 and 20 weeks of gestation as per the MTP act. They were randomly divided into two groups of 30 each-the study group received mifepristone 200 mg orally before misoprostol, whereas the control group was induced with misoprostol alone. The results were analyzed.


METHODS
Statistical analysis of the study was done using χ(2) test. The induction-abortion interval was significantly shorter in the study group, thereby decreasing the side-effects of the drug as well as duration of hospital stay.


CONCLUSIONS
This study, like many others, offers a reliable, safe, and cost-effective option by combining mifepristone before misoprostol to decrease the induction-abortion interval.
Terna Medical College, Navi Mumbai, India.
Kranti K
KK
Kulkarni
Mifepristone; Misoprostol; Second trimester abortion; Termination of pregnancy