Comparison of labial minor salivary gland biopsies from childhood Sjögren syndrome and age-matched controls.
OBJECTIVE
To determine an appropriate focus score cutoff for childhood Sjögren syndrome (SS).


METHODS
Labial salivary gland tissue from specimens from children with SS and age-matched controls was retrospectively identified and reviewed by a blinded oral pathologist.


RESULTS
The presence of any focal sialadenitis (focus score > 0 foci/4 mm(2)) was common among childhood SS samples but present in only 1 of 8 control samples.


CONCLUSIONS
The presence of any focal lymphocytic sialadenitis in minor labial salivary gland tissue is suggestive of childhood SS and should be included in future childhood SS-specific diagnostic or classification criteria.
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children's Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania.
Naoto
N
Yokogawa
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children's Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania. scott-lieberman@uiowa.edu.
Scott M
SM
Lieberman
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children's Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania.
Faizan
F
Alawi
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children's Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania.
Sharon
S
Bout-Tabaku
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children's Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania.
Marta
M
Guttenberg
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children's Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania.
David D
DD
Sherry
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children's Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania.
Frederick B
FB
Vivino
D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D012470:Salivary Glands, Minor / Q000473:pathology*; D012793:Sialadenitis / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000473:pathology*
DIAGNOSIS; MINOR SALIVARY GLANDS; PATHOLOGY; PEDIATRICS; SJÖGREN SYNDROME