Genotoxic effects and serum abnormalities in residents of regions proximal to e-waste disposal facilities in Jinghai, China.
Electronic waste (e-waste) disposal is a growing problem in China, and its effects on human health are a concern. To determine the concentrations of pollutants in peripheral blood and genetic aberrations near an e-waste disposal area in Jinghai, China, blood samples were collected from 30 (age: 41±11.01 years) and 28 (age: 33±2.14 years) individuals residing within 5 and 40km of e-waste disposal facilities in Jinghai (China), respectively, during the week of October 21-28, 2011. Levels of inorganic pollutants (calcium, copper, iron, lead, magnesium, selenium, and zinc) and malondialdehyde (MDA), identities of persistent organic pollutants (POPs), micronucleus rates, and lymphocyte subsets were analyzed in individuals. Total RNA expression profiles were analyzed by group and gender. The population group living in proximity to the e-waste site displayed significantly higher mean levels of copper, zinc, lead, MDAs, POPs (B4-6DE, B7-9DE, total polychlorinated biphenyls, and BB-153). In addition, micronucleus rates of close-proximity group were higher compared with the remote group (18.27% vs. 7.32%). RNA expression of genes involved in metal ion binding and transport, oxidation/reduction, immune defense, and tumorigenesis varied between groups, with men most detrimentally affected (p<0.05). CD4(+)/CD8(+)T cell ratios, CD4(+)CD25(nt/hi)CD127(lo)regulatory T cell percentages, and CD95 expression were greater in the e-waste group (p<0.05). Residing in close proximity to e-waste disposal facilities (≤5km) may be associated with the accumulation of potentially harmful inorganic/organic compounds and gender-preferential genetic aberrations.
Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, PR China. Electronic address: likeqiu68@aliyun.com.
KeQiu
K
Li
Tianjin Central Hospital of Gynecology Obstetrics, No. 156 Nankai Sanma Road Nankai District, Tianjin 300100, PR China. Electronic address: liushasha601@yahoo.com.cn.
ShaSha
S
Liu
State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University, Beijing 100871, PR China.
QiaoYun
Q
Yang
Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, PR China.
YuXia
Y
Zhao
Tianjin Central Hospital of Gynecology Obstetrics, No. 156 Nankai Sanma Road Nankai District, Tianjin 300100, PR China.
JunFang
J
Zuo
State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University, Beijing 100871, PR China.
Ran
R
Li
Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, PR China.
YaQing
Y
Jing
Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, PR China.
XiaoBo
X
He
State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University, Beijing 100871, PR China. Electronic address: xhqiu@pku.edu.cn.
XingHua
X
Qiu
Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, PR China. Electronic address: lig@tijmu.edu.cn.
Guang
G
Li
State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University, Beijing 100871, PR China.
Tong
T
Zhu
D000328:Adult; D015703:Antigens, CD / Q000235:genetics; D001774:Blood Chemical Analysis; D002681:China; D059029:Electronic Waste; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000706:statistics & numerical data; D008875:Middle Aged; D059467:Transcriptome; D064091:Waste Disposal Facilities
D015703:Antigens, CD; D004785:Environmental Pollutants
Electronic waste; Genetic damage; Malondialdehyde; Micronucleus; Persistent organic pollutants; lymphocyte subsets