The role of suppressors of cytokine signalling in human neoplasms.
Suppressors of cytokine signalling 1-7 (SOCS1-7) and cytokine-inducible SH2-containing protein (CIS) are a group of intracellular proteins that are well known as JAK-STAT and several other signalling pathways negative feedback regulators. More recently several members have been identified as tumour suppressors and dysregulation of their biological roles in controlling cytokine and growth factor signalling may contribute to the development of many solid organ and haematological malignancies. This review explores their biological functions and their possible tumour suppressing role in human neoplasms.
St George's Hospital Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK.
Walid
0000-0002-6924-8528
W
Sasi
St George's Hospital Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK.
Anup K
AK
Sharma
St George's Hospital Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK ; The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, UK.
Kefah
K
Mokbel