Neutrophil homeostasis and its regulation by danger signaling.
Hematopoiesis in general is demand driven and adaptive, but in contrast to erythropoiesis or thrombocytopoiesis, our knowledge on how neutrophil production is adapted to individual needs remains incomplete. Recently, neutrophil homeostasis has been shown to depend on danger receptors, macrophages, and even circadian rhythms. Puzzle pieces for a broader view of neutrophil homeostasis accumulate, and we will herein try to put seemingly contradictory evidence in a perspective of neutrophil homeostasis and emergency granulopoiesis determined by innate immunologic signaling.
Department of Medical Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, South West German Comprehensive Cancer Center, University Hospital of Tuebingen, Tuebingen, Germany.
Stefan
S
Wirths
Department of Medical Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, South West German Comprehensive Cancer Center, University Hospital of Tuebingen, Tuebingen, Germany.
Stefanie
S
Bugl
Department of Medical Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, South West German Comprehensive Cancer Center, University Hospital of Tuebingen, Tuebingen, Germany.
Hans-Georg
HG
Kopp
D000818:Animals; D025461:Feedback, Physiological; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology; D006410:Hematopoiesis / Q000235:genetics; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D051379:Mice; D064307:Microbiota / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D051197:Toll-Like Receptor 4 / Q000502:physiology
D051197:Toll-Like Receptor 4; D016179:Granulocyte Colony-Stimulating Factor