[Study on formulation of Scutellaria baicalensis extract phospholipid complex nasal preparation].
OBJECTIVE
To screen suitable nasal dosage forms of Scutellaria baicalensis extract phospholipid complex.


METHODS
Used the permeable performance of hyorrinis mucosa, nasal irritation and other evaluation indexes to screen five different formulations.


RESULTS
The submicroemulsion's apparent permeability coefficient was the largest, irritant was the smallest, and drug loading was higher than those of other formulations, which could meet the requirements of intranasal administration.


CONCLUSIONS
The optimum formulation of Scutellria baicalensis extract phospholipid complex nasal preparation is submicroemulsion.
Ya-Jun
YJ
Shi
Ming
M
Yang
Jun-Hui
JH
Shi
Jian-Yun
JY
Liu
Mei
M
Tang
D000281:Administration, Intranasal; D000818:Animals; D002025:Bufonidae; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004304:Dosage Forms; D016503:Drug Delivery Systems; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D005990:Glycerol / Q000008:administration & dosage; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism* / Q000473:pathology; D009821:Oils / Q000008:administration & dosage; D010539:Permeability; D010743:Phospholipids / Q000008:administration & dosage; D020442:Poloxamer / Q000008:administration & dosage; D011136:Polysorbates / Q000008:administration & dosage; D051381:Rats; D031364:Scutellaria baicalensis / Q000737:chemistry*; D013552:Swine
D004304:Dosage Forms; D004365:Drugs, Chinese Herbal; D009821:Oils; D010743:Phospholipids; D011136:Polysorbates; D020442:Poloxamer; D005990:Glycerol