Yttrium-90 radioembolization of malignant tumors of the liver: gallbladder effects.
OBJECTIVE
After (90)Y-microsphere radioembolization for unresectable hepatic neoplasms, the nearby gallbladder is susceptible to radiation-induced cholecystitis, an uncommon complication. The purpose of this study was to characterize the imaging findings after (90)Y radioembolization of the gallbladder and to assess the incidence of clinically significant radiation-induced cholecystitis.


METHODS
Medical records were retrospectively reviewed for cholecystectomy after (90)Y treatment of 133 consecutively registered patients (76 men, 57 women; average age, 65 years). Thirty-four of the patients had primary and 99 had secondary liver neoplasms. The pretreatment and posttreatment cross-sectional images of 85 of the patients were available for review.


RESULTS
Clinically significant radiation-induced cholecystitis occurred in 1 of the 133 patients (0.8%). After radioembolization, gallbladder imaging abnormalities were found in 84 of 85 patients (99%), but none was associated with clinically significant radiation-induced cholecystitis.


CONCLUSIONS
The incidence of clinically significant radiation-induced cholecystitis was only 0.8% despite a high prevalence of gallbladder imaging abnormalities after (90)Y radioembolization. Therefore, in the postinterventional care of patients with abdominal pain after (90)Y radioembolization, even if imaging abnormalities of the gallbladder are identified, cholecystectomy should be reserved for patients in whom other causes of pain have been excluded.
1 Department of Radiology, Interventional Radiology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065.
Alan A
AA
Sag
Michael A
MA
Savin
Nirish R
NR
Lal
Rajul R
RR
Mehta
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects* / Q000379:methods*; D002764:Cholecystitis / Q000453:epidemiology / Q000209:etiology*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D005704:Gallbladder / Q000528:radiation effects; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
D015021:Yttrium Radioisotopes