Margins in breast conservation: a clinician's perspective and what the literature tells us.
The optimal margin in breast-conserving surgery is controversial, and re-excision is common. Pathologic margin assessment is not standardized, and tumor biology and the use of systemic therapy have a major impact on local control. A study-level meta-analysis found no difference in local recurrence for margin widths of 1, 2, and 5 mm, leading a multidisciplinary panel to recommend adoption of no ink on tumor as the standard definition of a negative margin.
Screening and Test Evaluation Program (STEP), School of Public Health, Sydney Medical School, University of Sydney, Sydney, Australia; Royal Hospital for Women, Sydney, Australia.
Nehmat
N
Houssami
Monica
M
Morrow
D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D010506:Periodicals as Topic; D010820:Physicians
breast-conserving surgery; local recurrence; margins; re-excision