Dual views of SRF: a genomic exposure.
Esnault and colleagues (pp. 943-958) take a genomics approach to investigate the role of SRF (serum response factor) in the serum response of fibroblasts. The well-established dual role of SRF with alternative cofactors and responsiveness to two signaling pathways is illustrated at the genome-wide level, yet new insight comes from this global picture.
Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA;
Kathleen A
KA
Clark
Barbara J
BJ
Graves
D000199:Actins / Q000378:metabolism*; D000818:Animals; D005347:Fibroblasts / Q000502:physiology*; D044967:Serum / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic / Q000235:genetics*
D000199:Actins
MRTF; Rho; SRF; TCF; chromatin; signal transduction