Can anisodamine be a potential substitute for high-dose atropine in cases of organophosphate poisoning?
A case of organophosphate (OP) poisoning was admitted to the emergency room. The patient accepted treatment with pralidoxime (PAM), atropine, and supporting therapy. It was observed that even after 22 h after treatment, 960 mg of atropine was not enough for the patient to be atropinized. However, a 160-mg follow-up treatment of anisodamine was quite enough for atropinization after 4 h. As a case report, more studies are required before any definite conclusion can be reached regarding the use of anisodamine as a potential substitute for high-dose atropine in cases of OP poisoning.
Department of Emergency, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
W
W
Wang
Department of Respiratory, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China chenquanfang555@163.com.
Q-F
QF
Chen
Department of Emergency, the Fourth Affiliated Hospital, Guangxi Medical University, Liuzhou, Guangxi, China.
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HL
Ruan
Department of Emergency, the Second Affiliated Hospital, Guangxi Liuzhou Technical College of Medicine, Liuzhou, Guangxi, China.
K
K
Chen
Department of Medicine, the Second Affiliated Hospital, Guangxi Liuzhou Technical College of Medicine, Liuzhou, Guangxi, China.
B
B
Chen
Department of Medicine, the Second Affiliated Hospital, Guangxi Liuzhou Technical College of Medicine, Liuzhou, Guangxi, China.
J-M
JM
Wen
D000931:Antidotes / Q000627:therapeutic use*; D001285:Atropine / Q000627:therapeutic use; D002801:Cholinesterase Reactivators / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007306:Insecticides / Q000506:poisoning; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D062025:Organophosphate Poisoning / Q000188:drug therapy*; D011220:Pralidoxime Compounds / Q000627:therapeutic use; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*
D000931:Antidotes; D002801:Cholinesterase Reactivators; D007306:Insecticides; D018727:Muscarinic Antagonists; D011220:Pralidoxime Compounds; D012991:Solanaceous Alkaloids; C003922:anisodamine; D001285:Atropine; C028797:pralidoxime
Organophosphate poisoning; anisodamine; atropine; atropinization