One-carbon metabolism dietary factors and distal gastric cancer risk in chinese women.
BACKGROUND
Previous studies on the association between one-carbon dietary factors and gastric cancer risk have been inconsistent.


METHODS
We investigated this association using data from a prospective study, the Shanghai Women's Health Study (1997-2010), including 323 distal gastric cancer cases identified from 73,009 Chinese women. HRs and 95% confidence intervals (CI) were estimated using Cox proportional hazard regression after adjusting for confounders.


RESULTS
Overall, no statistically significant association of gastric cancer was observed with dietary intake of folate, methionine, or B vitamins. However, when stratified by menopausal status, higher intake of riboflavin was associated with decreased gastric cancer risk in premenopausal women with HR of 0.35 (95% CI, 0.17-0.73), 0.48 (0.24-0.97), 0.28 (0.12-0.65), and 0.23 (0.07-0.91), respectively, for the quintiles 2 to 5 intake groups compared with the lowest quintile intake (P for trend = 0.02). Among premenopausal women, highest intake of folate was associated with increased gastric cancer risk (HR, 2.62; 95% CI, 1.04-6.59). There were no statistically significant associations observed among postmenopausal women.


CONCLUSIONS
These results suggest that dietary factors involved in one-carbon metabolism are associated with gastric cancer risk among premenopausal women.


CONCLUSIONS
Riboflavin may be a protective factor and folate may be a risk factor for premenopausal gastric cancer.
Authors' Affiliations: Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Sun-Seog
SS
Kweon
Authors' Affiliations: Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee;
Xiao-Ou
XO
Shu
Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; and.
Yongbing
Y
Xiang
Authors' Affiliations: Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee;
Gong
G
Yang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland;
Bu-Tian
BT
Ji
Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; and.
Honglan
H
Li
Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; and.
Yu-Tang
YT
Gao
Authors' Affiliations: Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee;
Wei
W
Zheng
Authors' Affiliations: Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee; martha.shrubsole@vanderbilt.edu.
Martha J
MJ
Shrubsole
D000328:Adult; D000368:Aged; D044466:Asian People; D004032:Diet; D004034:Diet Surveys; D005260:Female; D005492:Folic Acid; D006801:Humans; D008715:Methionine; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000453:epidemiology*; D014803:Vitamin B Complex
D014803:Vitamin B Complex; D005492:Folic Acid; D008715:Methionine