Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging.
Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [(18)F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for (18)F-fluoride and 100% for (64)Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of (18)F from NPs, but no sign of efflux of (64)Cu.
King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Xianjin
X
Cui
King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Salome
S
Belo
King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Dirk
D
Krüger
School of Chemistry, Nottingham University, Nottingham NG7 2RD, UK.
Yong
Y
Yan
King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Rafael T M
RT
de Rosales
King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Maite
M
Jauregui-Osoro
School of Engineering and Applied Science, Aston University, Birmingham B4 7ET, UK.
Haitao
H
Ye
School of Engineering and Applied Science, Aston University, Birmingham B4 7ET, UK.
Shi
S
Su
CROmed Ltd., Baross u. 91-95, Budapest H-1047, Hungary.
Domokos
D
Mathe
CROmed Ltd., Baross u. 91-95, Budapest H-1047, Hungary.
Noémi
N
Kovács
CROmed Ltd., Baross u. 91-95, Budapest H-1047, Hungary.
Ildikó
I
Horváth
CROmed Ltd., Baross u. 91-95, Budapest H-1047, Hungary.
Mariann
M
Semjeni
King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Kavitha
K
Sunassee
Department of Biophysics and Radiation Biology, Nanobiotechnology & In Vivo Imaging Center, Semmelweis University, IX. Tűzoltó u. 37-47, Budapest H-1094, Hungary.
Krisztian
K
Szigeti
King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK; King's College London, Department of Physics, Strand Campus, London WC2R 2LS, UK. Electronic address: mark.a.green@kcl.ac.uk.
Mark A
MA
Green
King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK; King's College London, Division of Chemistry, Britannia House, 7 Trinity St, London SE1 1DB, UK. Electronic address: philip.blower@kcl.ac.uk.
Philip J
PJ
Blower
D000536:Aluminum Hydroxide / Q000737:chemistry; D000818:Animals; D003287:Contrast Media / Q000737:chemistry; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D017895:Manganese Compounds / Q000737:chemistry; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry; D049268:Positron-Emission Tomography
D003287:Contrast Media; D005290:Ferric Compounds; D005462:Fluorine Radioisotopes; D017895:Manganese Compounds; C551151:manganese ferrite; D000536:Aluminum Hydroxide; D052203:Ferrosoferric Oxide
(18)F; Aluminium hydroxide; Dual-modal; MR; Magnetic nanoparticles; PET