Discovering up-regulated VEGF-C expression in swine umbilical vein endothelial cells by classical swine fever virus Shimen.
Infection of domestic swine with the highly virulent Shimen strain of classical swine fever virus causes hemorrhagic lymphadenitis and diffuse hemorrhaging in infected swine. We analyzed patterns of gene expression for CSFV Shimen in swine umbilical vein endothelial cells (SUVECs). Transcription of the vascular endothelial growth factor (VEGF) C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in SUVECs. Our findings suggest that VEGF-C is involved in mechanisms of acute infection caused by virulent strains of CSFV.
Pengbo
P
Ning
College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China. zhangym@nwsuaf.edu.cn.
Yanming
Y
Zhang
Kangkang
K
Guo
Ru
R
Chen
Wulong
W
Liang
Zhi
Z
Lin
Helin
H
Li
D000818:Animals; D006691:Classical Swine Fever / Q000235:genetics* / Q000821:virology; D006692:Classical Swine Fever Virus / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D042783:Endothelial Cells / Q000378:metabolism; D020869:Gene Expression Profiling / Q000662:veterinary; D015967:Gene Expression Regulation, Viral; D013552:Swine; D013553:Swine Diseases / Q000235:genetics* / Q000821:virology; D014471:Umbilical Veins / Q000378:metabolism / Q000821:virology; D015854:Up-Regulation; D042582:Vascular Endothelial Growth Factor C / Q000235:genetics* / Q000378:metabolism; D014774:Virulence
D042582:Vascular Endothelial Growth Factor C