Effects of the inflammatory response on serum omentin levels in early acute and chronic pancreatitis.
OBJECTIVE
Acute pancreatitis is an acute inflammation of the parenchyma of the pancreas. Several adipokines have been investigated in acute pancreatitis, and these cytokines contribute to inflammation in acute pancreatitis. However, not enough data exist regarding omentin in injuries of the pancreas. Because of a possible common pathogenesis, we aimed to study the association between pancreatic damage and serum omentin levels.


METHODS
Twenty-four Sprague Dowley rats weighing 200-250 g were randomly placed into three groups: a sham group (n=8), an acute pancreatitis group (n=8), and a chronic pancreatitis group (n=8). Both rats in the sham group underwent laparotomy, and 0.1 cc of saline solution was injected through the pancreatic canal. On the seventh day, a blood sample was obtained by abdominal aorta puncture, and the pancreas was resected for histological examination. In the acute and chronic pancreatitis groups, 0.1 cc of 4.5% Sodium Taurocholote was injected through the pancreatic canal. Blood samples were obtained and pancreatic resection was performed after 24 hours for the acute pancreatitis group and after 7 days for the chronic pancreatitis group.


RESULTS
Serum omentin levels of rats with chronic pancreatitis (49.37±2.82 ng/ml) were increased compared to both acute pancreatitis (37.79±1.24 ng/ml) (p<0.01) and sham rats (22.49±1.4 ng/ml) (p<0.01). In addition, the omentin level of rats with acute pancreatitis was significantly increased compared to the sham group (p<0.01).


CONCLUSIONS
The elevation in omentin levels in rats in the early stage of pancreatitis was due to the anti-inflammatory effects of omentin; hence, elevated omentin levels improved insulin resistance and caused a significant reduction in glucose levels.
Departments of General Surgery, Abant Izzet Baysal University Hospital, Bolu, Turkey.
M
M
Sit
Departments of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
G
G
Aktas
Departments of General Surgery, Abant Izzet Baysal University Hospital, Bolu, Turkey.
E E
EE
Yilmaz
Departments of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
A
A
Alcelik
Departments of Hystology, Abant Izzet Baysal University Hospital, Bolu, Turkey.
E H
EH
Terzi
Departments of Biochemistry, Abant Izzet Baysal University Hospital, Bolu, Turkey.
M
M
Tosun
D000208:Acute Disease; D000818:Animals; D016207:Cytokines / Q000097:blood*; D037102:Lectins / Q000097:blood*; D010195:Pancreatitis / Q000097:blood* / Q000276:immunology*; D050500:Pancreatitis, Chronic / Q000097:blood / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D016207:Cytokines; D037102:Lectins; C000591992:omentin protein, rat