Mixed adenoneuroendocrine gastric carcinoma: a case report and review of the literature.
We present a rare case of a gastric mixed adenoneuroendocrine tumor and review the related English literature. A 77-year-old Caucasian woman was admitted to our department with nausea, anorexia, weight loss, and anemia. Esophagogastroduodenoscopy showed a large (>7 cm) ulcerative mass in the greater curvature of the stomach. Biopsy showed the presence of an adenocarcinoma with moderate differentiation. The patient underwent D2 subtotal gastrectomy. Histopathological analysis revealed a diagnosis of mixed gastric adenoneuroendocrine carcinoma. The post-operative course was uneventful, and at the 6-month follow-up, the patient was alive without evidence of recurrence. Our review of the English literature suggested that such cases are most often reported from eastern countries. Multimodal treatment should be the aim for these patients because of the neuroendocrine component of the tumor.
Department of Digestive Surgery, Regina Elena National Cancer Institute, Rome, Italy.
Giovanni Battista
GB
Levi Sandri
Department of Digestive Surgery, Regina Elena National Cancer Institute, Rome, Italy.
Fabio
F
Carboni
Department of Digestive Surgery, Regina Elena National Cancer Institute, Rome, Italy.
Mario
M
Valle
Department of Pathology, Regina Elena National Cancer Institute, Rome, Italy.
Paolo
P
Visca
Department of Digestive Surgery, Regina Elena National Cancer Institute, Rome, Italy.
Alfredo
A
Garofalo
Adenoneuroendocrine; Collision tumor; Mixed tumor; Stomach neoplasms; Surgery