Enantioselective insertion of a carbenoid carbon into a C-C bond to expand cyclobutanols to cyclopentanols.
When a carbenoid species generated from a tosylhydrazone is reacted with a cyclobutanol in the presence of a chiral rhodium catalyst, a C-C single bond of the cyclobutanol is cleaved, and the carbenoid carbon is inserted therein to furnish a ring-expanded cyclopentanol in an enantioselective manner.
Department of Synthetic Chemistry and Biological Chemistry, Kyoto University , Katsura, Kyoto 615-8510, Japan.
Akira
A
Yada
Shoichiro
S
Fujita
Masahiro
M
Murakami