Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype.
T-cell large granular lymphocyte (T-LGL) leukemia represents a clonal proliferation of cytotoxic T-cells which etiology has not been entirely elucidated. However, CD4(+), CD4(-), CD8(-), CD4(+), CD8(+) cases have been described. The disease is usually characterized by cytopenias and a modest lymphocytosis. The majority of patients with T-LGL leukemia remains asymptomatic for a long period and will require treatment later during the course of their disease. Hereby we describe a case of T-LGL leukemia diagnosed by flow cytometry, which presented indolent course and required no treatment so far.
Laboratory of Hematology, Unit of Molecular Biology, University Hospital of Ioannina;
Panagiota K
PK
Petsa
Laboratory of Hematology, Unit of Molecular Biology, University Hospital of Ioannina;
Achilleas
A
Karamoutsios
Laboratory of Hematology, Unit of Molecular Biology, University Hospital of Ioannina;
Lefkothea
L
Dova
Laboratory of Hematology, Unit of Molecular Biology, University Hospital of Ioannina;
Leonidas
L
Benetatos
Laboratory of Hematology, Unit of Molecular Biology, University Hospital of Ioannina;
Asimina
A
Petsiou
Laboratory of Hematology, University Hospital of Ioannina;
Nikolaos
N
Kolaitis
General Hospital of Corfu, Laboratory of Hematology, Corfu, Greece.
Antonis
A
Georgopoulos
Laboratory of Hematology, Unit of Molecular Biology, University Hospital of Ioannina;
Georgios
G
Vartholomatos
T cell receptor; T-LGL leukemia; flow cytometry.; large granular lymphocytes