Diet patterns and risk of squamous cell oesophageal carcinoma: a case-control study in Uruguay.
BACKGROUND
Oesophageal cancer presents high incidence rates in the so-called Brazilian-Uruguayan belt.


METHODS
The present study included 1,170 participants (234 cases and 936 controls) which were analyzed by unconditional multiple logistic regression in order to examine risk of oesophageal squamous cell carcinoma (OESCC) associated with several food groups.


RESULTS
Boiled red meat (OR 2.59, 95%CI 1.69-3.97), lamb meat (OR 1.64, 95%CI 1.07-2.51), processed meat (OR 1.49, 95%CI 1.01-2.21), whole milk (OR 1.78, 1.19-1.68), fresh vegetables and fruits (OR 0.42, 95%CI 0.27-0.63), mate consumption (OR 2.04, 95%CI 1.32- 3.16), and black tea (OR 0.10, 95%CI 0.04-0.28) were significantly associated with risk of OESCC.


CONCLUSIONS
Hot beverages (mate) and hot foods (boiled meat) appear to be important determinants in the risk of OESCC, allowing the penetration of carcinogens in tobacco and alcohol into the oesophageal mucosa.
Epidemiology Group, Department of Pathology, School of Medicine, University of the Republic, Uruguay E-mail : edestefani@gmail.com.
Eduardo
E
De Stefani
Hugo
H
Deneo-Pellegrini
Alvaro L
AL
Ronco
Paolo
P
Boffetta
Pelayo
P
Correa
Maria
M
Mendilaharsu
Gisele
G
Acosta
Aldo
A
Quarneti
Cecilia
C
Silva
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D004032:Diet / Q000009:adverse effects*; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D014583:Uruguay / Q000453:epidemiology