Panax red ginseng extract regulates energy expenditures by modulating PKA dependent lipid mobilization in adipose tissue.
Regulation of balance between lipid accumulation and energy consumption is a critical step for the maintenance of energy homeostasis. Here, we show that Panax red ginseng extract treatments increased energy expenditures and prevented mice from diet induced obesity. Panax red ginseng extracts strongly activated Hormone Specific Lipase (HSL) via Protein Kinase A (PKA). Since activation of HSL induces lipolysis in WAT and fatty acid oxidation in brown adipose tissue (BAT), these results suggest that Panax red ginseng extracts reduce HFD induced obesity by regulating lipid mobilization.
Department of Biomedical Sciences, Cell Dysfunction Research Center (CDRC), University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea.
Hae-Mi
HM
Cho
Department of Biomedical Sciences, Cell Dysfunction Research Center (CDRC), University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea.
Young-Ho
YH
Kang
Department of Biomedical Sciences, Cell Dysfunction Research Center (CDRC), University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea.
Hanju
H
Yoo
Department of Anatomy and Cell Biology, University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea.
Seung-Yong
SY
Yoon
Department of Biomedical Sciences, Cell Dysfunction Research Center (CDRC), University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea; Department of Anatomy and Cell Biology, University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea.
Sang-Wook
SW
Kang
Department of Biomedical Sciences, Cell Dysfunction Research Center (CDRC), University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea; Department of Anatomy and Cell Biology, University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea.
Eun-Ju
EJ
Chang
Department of Biomedical Sciences, Cell Dysfunction Research Center (CDRC), University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea; Department of Anatomy and Cell Biology, University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea. Electronic address: ysong@amc.seoul.kr.
Youngsup
Y
Song
D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism*; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism; D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D059305:Diet, High-Fat; D004734:Energy Metabolism / Q000187:drug effects*; D008053:Lipid Mobilization / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000378:metabolism / Q000517:prevention & control; D005894:Panax; D010936:Plant Extracts / Q000494:pharmacology
D010936:Plant Extracts; D017868:Cyclic AMP-Dependent Protein Kinases; D055372:AMP-Activated Protein Kinases
Adipose tissue; Energy expenditures; Obesity; Panax ginseng; Protein Kinase A