[Research progress on human acute leukemia xenograft mouse models].
The methods for modeling human acute leukemia in mice include xenotransplantation of human leukemia cells, retroviral transduction/transplantation, transgenesis, chemical mutagenesis and insertional mutagenesis. Establishing human acute leukemia mouse models through xenograft is an important way to study acute leukemia. This review focuses on the newest progress of studies on human acute leukemia xenograft mouse models in the regards of the immunodeficiency mouse, preconditioning, cytokines, cell transplantation, the evaluation and application of model.
Medical School of Southeast University, Nanjing 210009, Jiangsu Province, China.
Yan-Ting
YT
Guo
Department of Hematology, Nanjing Drum Tower Hospital, Nanjing 210008, Jiangsu Province, China.
Juan
J
Li
Department of Hematology, Nanjing Drum Tower Hospital, Nanjing 210008, Jiangsu Province, China. E-mail: oy626@sina.com.
Jian
J
Ouyang
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D064593:Heterografts; D006801:Humans; D007938:Leukemia; D051379:Mice