First Trimester Diagnosis of VACTERL Association.
VACTERL association (OMIM 192350) is a non-random combination of multiple congenital malformations including vertebral, anal, cardiac, tracheoesophageal, renal and limb anomalies. The wide spectrum of defects suggests the occurrence of defective development during early embryogenesis. The authors report a case of a complex polymalformative association detected by ultrasound in the first trimester of pregnancy. The ensuing fetal study revealed the presence of vertebral, anorectal, renal and limb anomalies and therefore was considered a case of VACTERL association. This complex association generally entails a poor prognosis. Its early detection allows discussion of management options, including medical termination of pregnancy.
Department of Obstetrics and Gynecology, São Teotónio Hospital , Viseu.
Joana
J
Santos
Laboratory of Anatomic Pathology, CGC Genetics , Porto, Portugal.
Rosete
R
Nogueira
Department of Obstetrics and Gynecology, São Teotónio Hospital , Viseu.
Rita
R
Pinto
Department of Obstetrics and Gynecology, São Teotónio Hospital , Viseu.
Isabel
I
Cerveira
Department of Obstetrics and Gynecology, São Teotónio Hospital , Viseu.
Susana
S
Pereira
VACTERL association; VATER association; first trimester diagnosis