Antimicrobial peptides.
With increasing antibiotics resistance, there is an urgent need for novel infection therapeutics. Since antimicrobial peptides provide opportunities for this, identification and optimization of such peptides have attracted much interest during recent years. Here, a brief overview of antimicrobial peptides is provided, with focus placed on how selected hydrophobic modifications of antimicrobial peptides can be employed to combat also more demanding pathogens, including multi-resistant strains, without conferring unacceptable toxicity.
Department of Pharmacy, Uppsala University , Uppsala , Sweden.
Martin
M
Malmsten
D000890:Anti-Infective Agents / Q000494:pharmacology*; D057927:Hydrophobic and Hydrophilic Interactions; D010455:Peptides / Q000494:pharmacology*
D000890:Anti-Infective Agents; D010455:Peptides
AMP; antimicrobial peptide; bacteria; liposome; membrane